Accurate measurement of the helical twisting power of chiral dopants
Kosa, Tamas; Bodnar, Volodymyr; Taheri, Bahman; Palffy-Muhoray, Peter
2002-03-01
We propose a method for the accurate determination of the helical twisting power (HTP) of chiral dopants. In the usual Cano-wedge method, the wedge angle is determined from the far-field separation of laser beams reflected from the windows of the test cell. Here we propose to use an optical fiber based spectrometer to accurately measure the cell thickness. Knowing the cell thickness at the positions of the disclination lines allows determination of the HTP. We show that this extension of the Cano-wedge method greatly increases the accuracy with which the HTP is determined. We show the usefulness of this method by determining the HTP of ZLI811 in a variety of hosts with negative dielectric anisotropy.
... taking 5-HTP by mouth does not help symptoms of Alzheimer's disease. Anxiety. Evidence on the effects of 5-HTP for anxiety is unclear. Early research shows that taking 25-150 mg of ... anxiety symptoms in people with anxiety disorders. However, other early ...
A Simple Method to Measure the Twist Elastic Constant of a Nematic Liquid Crystal
2015-01-01
as 180° super- twisted nematic (STN) cell. Next, we assume the helical twisting power ( HTP ) of chiral dopant is also unknown, same as K22. To solve...threshold voltages of these two 180° STN cells, both K22 and HTP can be obtained simultaneously. In the whole process, there is no need to measure...Equation (1), if we sub- stitute ϕ = π and pitch length P = 1/( HTP · c) (where c is chiral concentration), then the critical voltage can be rewritten
Noto, Anthony G.; Marshall, Kenneth L.
2005-08-01
Until recently, it has not been possible to determine, with any real certainty, a complete picture of "chirality" (absolute configuration, optical rotation direction, and helical twisting power) for new chiral compounds without first synthesizing, purifying, characterizing, and testing every new material. Recent advances in computational chemistry now allow the prediction of certain key chiral molecular properties prior to synthesis, which opens the possibility of predetermining the "chiroptical" properties of new liquid crystal dopants and mixtures for advanced optical and photonics applications. A key element to this activity was the development of both the chirality index (G0) by Osipov et al., and the scaled chirality index (G0S) by Solymosi et al., that can be used as a "figure of merit" for molecular chirality. Promising correlations between G0S and both circular dichroism (CD) and the helical twisting power (HTP) of a chiral dopant in a liquid crystal host have been shown by Neal et al., Osipov, and Kuball. Our work improves the predictive capabilities of G0S by taking into account the actual mass of each atom in the molecule in the calculations; in previous studies the mass of each atom was assumed to be equal. This "weighted" scaled chirality index (G0SW) was calculated and correlated to existing experimental HTP data for each member of a series of existing, well-known chiral compounds. The computed HTP using G0SW for these model systems correlated to the experimental data with remarkable accuracy. Weighted, scaled chiral indices were also calculated for the first time for a series of novel chiral transition metal dithiolene dyes for near-IR liquid crystal device applications.
Nematic twist cell: Strong chirality induced at the surfaces
Lin, Tzu-Chieh; Nemitz, Ian R.; Pendery, Joel S.; Schubert, Christopher P. J.; Lemieux, Robert P.; Rosenblatt, Charles
2013-04-01
A nematic twist cell having a thickness gradient was filled with a mixture containing a configurationally achiral liquid crystal (LC) and chiral dopant. A chiral-based linear electrooptic effect was observed on application of an ac electric field. This "electroclinic effect" varied monotonically with d, changing sign at d =d0 where the chiral dopant exactly compensated the imposed twist. The results indicate that a significant chiral electrooptic effect always exists near the surfaces of a twist cell containing molecules that can be conformationally deracemized. Additionally, this approach can be used to measure the helical twisting power (HTP) of a chiral dopant in a liquid crystal.
Energy Technology Data Exchange (ETDEWEB)
Canters, R A M; Franckena, M; Zee, J van der; Rhoon, G C van [Erasmus MC, Daniel den Hoed Cancer Center, Department of Radiation Oncology, hyperthermia unit, Rotterdam (Netherlands)], E-mail: r.canters@erasmusmc.nl
2008-12-07
For an efficient clinical use of HTP (hyperthermia treatment planning), optimization methods are needed. In this study, a complaint-adaptive PD (power density) optimization as a tool for HTP-guided steering in deep hyperthermia of pelvic tumors is developed and tested. PD distribution in patients is predicted using FE-models. Two goal functions, Opt1 and Opt2, are applied to optimize PD distributions. Optimization consists of three steps: initial optimization, adaptive optimization after a first complaint and increasing the weight of a region after recurring complaints. Opt1 initially considers only target PD whereas Opt2 also takes into account hot spots. After patient complaints though, both limit PD in a region. Opt1 and Opt2 are evaluated in a phantom test, using patient models and during hyperthermia treatment. The phantom test and a sensitivity study in ten patient models, show that HTP-guided steering is most effective in peripheral complaint regions. Clinical evaluation in two groups of five patients shows that time between complaints is longer using Opt2 (p = 0.007). However, this does not lead to significantly different temperatures (T50s of 40.3 (Opt1) versus 40.1 deg. C (Opt2) (p = 0.898)). HTP-guided steering is feasible in terms of PD reduction in complaint regions and in time consumption. Opt2 is preferable in future use, because of better complaint reduction and control.
Canters, R. A. M.; Franckena, M.; van der Zee, J.; Van Rhoon, G. C.
2008-12-01
For an efficient clinical use of HTP (hyperthermia treatment planning), optimization methods are needed. In this study, a complaint-adaptive PD (power density) optimization as a tool for HTP-guided steering in deep hyperthermia of pelvic tumors is developed and tested. PD distribution in patients is predicted using FE-models. Two goal functions, Opt1 and Opt2, are applied to optimize PD distributions. Optimization consists of three steps: initial optimization, adaptive optimization after a first complaint and increasing the weight of a region after recurring complaints. Opt1 initially considers only target PD whereas Opt2 also takes into account hot spots. After patient complaints though, both limit PD in a region. Opt1 and Opt2 are evaluated in a phantom test, using patient models and during hyperthermia treatment. The phantom test and a sensitivity study in ten patient models, show that HTP-guided steering is most effective in peripheral complaint regions. Clinical evaluation in two groups of five patients shows that time between complaints is longer using Opt2 (p = 0.007). However, this does not lead to significantly different temperatures (T50s of 40.3 (Opt1) versus 40.1 °C (Opt2) (p = 0.898)). HTP-guided steering is feasible in terms of PD reduction in complaint regions and in time consumption. Opt2 is preferable in future use, because of better complaint reduction and control.
Photoswitching of helical twisting power by chiral photochromic diarylethene dopants
Yamaguchi, Tadatsugu; Irie, Masahiro
2002-12-01
Two kinds of chiral diarylethene derivatives were synthesized and used as dopants for photoresponsive liquid crystals. Both derivatives underwent thermally irreversible and fatigue resistant photochromic reactions and exhibited reversible circular diochroism (CD) spectral changes. Large photostimulated pitch chances of chiral nematic K-15 liquid crystals were observed by the addition of the derivatives as dopants. The relation between the optical rotation and the twisting power force was discussed.
Using Pretwist to Reduce Power Loss of Bend-Twist Coupled Blades
DEFF Research Database (Denmark)
Stäblein, Alexander; Tibaldi, Carlo; Hansen, Morten Hartvig
2016-01-01
Bend-twist coupling of wind turbine blades is known as a means to reduce the structural loads of the turbine. While the load reduction is desirable, bend-twist coupling also leads to a decrease in the annual energy production of the turbine. The reduction is mainly related to a no longer optimal...... twist distribution along the blade due to the coupling induced twist. Some of the power loss can be compensated by pretwisting the blade. This paper presents a pretwisting procedure for large blade deflections and investigates the effect of pretwisting on blade geometry, annual energy production...
5-HTP hypothesis of schizophrenia.
Fukuda, K
2014-01-01
To pose a new hypothesis of schizophrenia that affirms and unifies conventional hypotheses. Outside the brain, there are 5-HTP-containing argyrophil cells that have tryptophan hydroxylase 1 without l-aromatic amino acid decarboxylase. Monoamine oxidase in the liver and lung metabolize 5-HT, rather than 5-HTP, and 5-HTP freely crosses the blood-brain barrier, converting to 5-HT in the brain. Therefore I postulate that hyperfunction of 5-HTP-containing argyrophil cells may be a cause of schizophrenia. I investigate the consistency of this hypothesis with other hypotheses using a deductive method. Overactive 5-HTP-containing argyrophil cells produce excess amounts of 5-HTP. Abundant 5-HTP increases 5-HT within the brain (linking to the 5-HT hypothesis), and leads to negative feedback of 5-HT synthesis at the rate-limiting step catalysed by tryptophan hydroxylase 2. Owing to this negative feedback, brain tryptophan is further metabolized via the kynurenine pathway. Increased kynurenic acid contributes to deficiencies of glutamate function and dopamine activity, known causes of schizophrenia. The 5-HTP hypothesis affirms conventional hypotheses, as the metabolic condition caused by acceleration of tryptophan hydroxylase 1 and suppression of tryptophan hydroxylase 2, activates both 5-HT and kynurenic acid. In order to empirically test the theory, it will be useful to monitor serum 5-HTP and match it to different phases of schizophrenia. This hypothesis may signal a new era with schizophrenia treated as a brain-gut interaction. Copyright © 2013 Elsevier Ltd. All rights reserved.
Nayek, Prasenjit; Li, Guoqiang
2015-01-01
Blue phase liquid crystal (BPLC) has important applications in adaptive lenses and phase modulators due to its polarization-independent property. During our efforts for development of the new materials, we found a novel phenomenology of phase transition, from focal conic smectic to smectic blue phase in a partially fluorinated cyanophenyl alkyl benzoate ester based nematic liquid crystal (LCM-5773) doped by ultra-high twisting power [H.T.P~160 um^-1] chiral dopant (R5011/3 wt%). Polarized optical microscopy (POM) investigations revealed focal conic and fan-shaped textures typical for columnar mesophases. These focal conic domains (FCDs) are squeezed under electric field and finally at a critical electric field they undergo a dark state. When the electric field is withdrawn, the FCDs are regrown in a one dimensional array with smaller domain size. Interestingly, we have observed the domain size of the FCDs can grow several times by decreasing the cooling rate (0.02 degrees(C)/min.) ten times without any change...
5-HTP efficacy and contraindications
Directory of Open Access Journals (Sweden)
Hinz M
2012-07-01
Full Text Available Marty Hinz,1 Alvin Stein,2 Thomas Uncini31Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, USA; 3University Medical Center Mesabi Hibbing, MN, USAAbstract: L-5-hydroxytryptophan (5-HTP is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science. Under close examination, 5-HTP may be contraindicated for depression in some of the very patients for whom promoters of 5-HTP advocate its use.Keywords: 5-HTP, 5-hydroxytryptophan, L-5-HTP, L-5-hydroxytryptophan
5-HTP efficacy and contraindications.
Hinz, Marty; Stein, Alvin; Uncini, Thomas
2012-01-01
L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science. Under close examination, 5-HTP may be contraindicated for depression in some of the very patients for whom promoters of 5-HTP advocate its use.
Yamada, Jun; Sugimoto, Yumi; Ujikawa, Masanori
2006-03-01
We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. It was reported that administration of 5-HTP elicits hypophagia in rodents and humans. In the present study, we examined involvement of leptin in 5-HTP-elicited decreases in the milk intake of fasted mice. Serum leptin levels increased with increases in milk intake in mice, while 5-HTP strongly decreased milk intake in fasted mice compared to that in the control group. Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake. As leptin is a powerful anorectic signal, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.
Effect of Turbulence on Power for Bend-Twist Coupled Blades
Stäblein, Alexander R.; Hansen, Morten H.
2016-09-01
Bend-twist coupling of wind turbine blades reduces the structural loads of the turbine but it also results in a decrease of the annual energy production. The main part of the power loss can be mitigated by pretwisting the blade, but some power loss remains and previous studies indicate that it might be related to the dynamic response of bend-twist coupled blades in turbulent flow. This paper contains estimations of the power curve from nonlinear time simulations, a linear frequency domain based method and a normal distribution weighted average method. It is shown that the frequency domain based estimation is highly dependant on the validity of the linearized model, thus estimations are poor for operational points close to rated wind speed. The weighted average method gives good results if an appropriate standard deviation is known a priori. The nonlinear time simulations show that changes in power due to turbulence are similar for coupled and uncoupled blades. Power gains at low wind speeds are related to the curvature of the steady state power curve. Losses around rated wind speed are caused by the effects of controller switching between partial and full power operation.
Self pressuring HTP feed systems
Energy Technology Data Exchange (ETDEWEB)
Whitehead, J.
1999-10-14
Hydrogen peroxide tanks can be pressurized with decomposed HTP (high test hydrogen peroxide) originating in the tank itself. In rocketry, this offers the advantage of eliminating bulky and heavy inert gas storage. Several prototype self-pressurizing HTP systems have recently been designed and tested. Both a differential piston tank and a small gas-driven pump have been tried to obtain the pressure boost needed for flow through a gas generator and back to the tank. Results include terrestrial maneuvering tests of a prototype microsatellite, including warm gas attitude control jets.
5-HTP efficacy and contraindications
Hinz M; Stein A; Uncini T
2012-01-01
Marty Hinz,1 Alvin Stein,2 Thomas Uncini31Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, USA; 3University Medical Center Mesabi Hibbing, MN, USAAbstract: L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of...
Institute of Scientific and Technical Information of China (English)
Hai Quan Zhang; An Lei Qin
2012-01-01
In this study,a novel series of chiral 1,2-propanediol derivatives with different electron-donating and electron-withdrawing groups were synthesized and characterized by FT-IR and 1H NMR.The helical twisting properties of all the chiral dopants were investigated by doping the chiral dopants into a nematic liquid crystal host (SLC- 1717).The results indicate that the donor-acceptor electron effect have a prominent influence on helical twisting property of the chiral nematic phase induced by the chiral dopants.Introducing electron-withdrawing groups into the terminal ends of chiral 1,2-propanediol can decrease the absolute values of the helical twisting power.In addition,the helix inversion temperatures of the induced chiral nematic phase are variational with the change of terminal groups.
iGrab: hand orthosis powered by twisted and coiled polymer muscles
Saharan, Lokesh; de Andrade, Monica Jung; Saleem, Wahaj; Baughman, Ray H.; Tadesse, Yonas
2017-10-01
Several works have been reported in powered hand orthosis in the last ten years for assistive or rehabilitative purposes. However, most of these approaches uses conventional actuators such as servo motors to power orthosis. In this work, we demonstrate the recently reported twisted and coiled polymeric (TCP) muscles to drive a compact, light, inexpensive and wearable upper extremity device, iGrab. A 3D printed orthotic hand module was designed, developed and tested for the performance. The device has six 2-ply muscles of diameter 1.35 mm with a length of 380 mm. We used a single 2-ply muscle for each finger and two 2-ply muscles for the thumb. Pulsed actuation of the muscles at 1.8 A current for 25 s with 7% duty cycle under natural cooling showed full flexion of the fingers within 2 s. Modeling and simulation were performed on the device using standard Euler–Lagrangian equations. Our artificial muscles powered hand orthosis demonstrated the capability of pinching and picking objects of different shapes, weights, and sizes.
CSIR Research Space (South Africa)
Forbes, A
2010-12-01
Full Text Available Research at the Mathematical Optics Group uses "twisted" light to study new quatum-based information security systems. In order to understand the structure of "twisted" light, it is useful to start with an ordinary light beam with zero twist, namely...
Analysis list: htp-3 [Chip-atlas[Archive
Lifescience Database Archive (English)
Full Text Available htp-3 Adult + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/htp-3.1.t...sv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/htp-3.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/htp...-3.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/htp-3.Adult.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Adult.gml ...
The kink instability in infinite cylindrical flux tubes - Eigenvalues for power-law twist profiles
Craig, I. J. D.; Robb, T. D.; Sneyd, A. D.; McClymont, A. N.
1990-04-01
Simple, accurate methods of calculating ideal MHD instability eigenvalues for infinitely long cylindrical tubes with twist function T(r) are developed. The results show that the most rapidly growing and energetic instabilities occur in the Gold-Hoyle v = 0 field, with the instability progressively weakening with increasing v. However, the maximum force eigenvalue is always small, so that even in the Gold-Hoyle case only a small proportion of the available magnetic energy can be released in the linear phase. The results also confirm that the linear pinch is remarkably weak yet relatively resistant to line-tying. It is shown that the weakness of the force eigenvalue implies that the influence of uniform gas pressure on stability is negligible. Implications for the energy-release mechanism in solar flares are discussed.
L-5HTP treatment and serum 5-HT level after L-5-HTP loading on depressed patients.
Kaneko, M; Kumashiro, H; Takahashi, Y; Hoshino, Y
1979-01-01
Based on 5-HT hypothesis, L-5-HTP (150 or 300 mg/day) was given orally to 18 depressed patients. The global estimates were 2 very much improved; 8 much improved; 3 minimally improved, and 5 unchanged. The action of L-5-HTP was usually rapid. The elevation of the serum 5-HT level 1 week after L-5-HTP administration was relatively lower in the 5-HTP nonresponder group, compared with the responders. The chronological change of the serum 5-HT level in depressed patients after an oral loading dose of 3 mg/kg of L-5-HTP showed a gradual and slight elevation, compared with manic and normal groups. It seemed that the therapeutic effect of L-5-HTP on responders was related to lower 5-HT level in the brain for their pathogenesis, and that there was a metabolic disturbance of L-5-HTP into 5-HT in some depressed patients.
Dissociation of the anorectic actions of 5-HTP and fenfluramine.
Fletcher, P J; Burton, M J
1986-01-01
The possible peripheral anorectic actions of 5-hydroxytryptophan (5-HTP) and fenfluramine were examined in food-deprived rats. In a 1-h feeding test the peripherally acting 5-HT antagonist, xylamidine, attenuated the reductions in food intake induced by 5-HT and 5-HTP but not fenfluramine. Thus, the anorectic action of 5-HTP appears to be mediated in part by peripheral 5-HT receptors. Microstructural analyses showed that 5-HTP and fenfluramine induced decreases in eating rate and bout size. Xylamidine reversed the effect of 5-HTP on eating rate, and induced a slight increase in bout size in its own right. Therefore, the peripheral effect of 5-HTP appears to be a slowing of eating rate. No effects of xylamidine on fenfluramine induced changes in feeding were observed. The results indicate a dissociation of the anorectic effects of 5-HTP and fenfluramine based on a peripheral action of 5-HTP. The peripheral action of 5-HTP differs from the previously reported reductions in bout size and bout duration induced by 5-HT. Possible mechanisms for this difference in the peripheral actions of 5-HT and 5-HTP are discussed.
Optimisation Study of a Homogeneously-Catalysed HTP Rocket Engine
Musker, A.; Roberts, G.; Chandler, P.; Grayson, J.; Holdsworth, J.
2004-10-01
The decomposition of hydrogen peroxide (HTP) using a liquid catalyst offers an alternative to the employment of traditional catalyst packs. A test rig has been used to estimate the length of chamber required for complete decomposition to take place for the case of HTP with a phosphorus content some 10000 times the level normally associated with rocket-grade HTP. Complete decomposition within a 10 mm advection length was achieved.
Dullin, Holger R
2015-01-01
A complete description of twisting somersaults is given using a reduction to a time-dependent Euler equation for non-rigid body dynamics. The central idea is that after reduction the twisting motion is apparent in a body frame, while the somersaulting (rotation about the fixed angular momentum vector in space) is recovered by a combination of dynamic and geometric phase. In the simplest "kick-model" the number of somersaults $m$ and the number of twists $n$ are obtained through a rational rotation number $W = m/n$ of a (rigid) Euler top. This rotation number is obtained by a slight modification of Montgomery's formula [9] for how much the rigid body has rotated. Using the full model with shape changes that take a realistic time we then derive the master twisting-somersault formula: An exact formula that relates the airborne time of the diver, the time spent in various stages of the dive, the numbers $m$ and $n$, the energy in the stages, and the angular momentum by extending a geometric phase formula due to C...
Dickens, Charles
2005-01-01
Oliver Twist is one of Dickens's most popular novels, with many famous film, television and musical adaptations. It is a classic story of good against evil, packed with humour and pathos, drama and suspense, in which the orphaned Oliver is brought up in a harsh workhouse, and then taken in and
Dickens, Charles
2005-01-01
Oliver Twist is one of Dickens's most popular novels, with many famous film, television and musical adaptations. It is a classic story of good against evil, packed with humour and pathos, drama and suspense, in which the orphaned Oliver is brought up in a harsh workhouse, and then taken in and explo
Hermann, Keith; Pratumyot, Yaowalak; Polen, Shane; Hardin, Alex M; Dalkilic, Erdin; Dastan, Arif; Badjić, Jovica D
2015-02-23
A preparative procedure for obtaining a pair of twisted molecular baskets, each comprising a chiral framework with either right ((P)-1syn) or left ((M)-1syn) sense of twist and six ester groups at the rim has been developed and optimized. The racemic (P/M)-1syn can be obtained in three synthetic steps from accessible starting materials. The resolution of (P/M)-1syn is accomplished by its transesterification with (1R,2S,5R)-(-)-menthol in the presence of a Ti(IV) catalyst to give diastereomeric 8(P) and 8(M). It was found that dendritic-like cavitands 8(P) and 8(M), in CD2Cl2, undergo self-inclusion ((1)H NMR spectroscopy) with a menthol moiety occupying the cavity of each host. Importantly, the degree of inclusion of the menthol group was ((1)H NMR spectroscopy) found to be greater in the case of 8(P) than 8(M). Accordingly, it is suggested that different folding characteristic of 8(P) and 8(M) ought to affect the physicochemical characteristics of the hosts to permit their effective separation by column chromatography. The absolute configuration of 8(P)/8(M), encompassing right- and left-handed "cups", was determined with the exciton chirality method and also verified in silico (DFT: B3LYP/TZVP). Finally, the twisted baskets are strongly fluorescent due to three naphthalene chromophores, having a high fluorescence quantum yield within the rigid framework of 8(P)/8(M).
Siemens advance PWR fuel assemblies (HTP) and cladding
Energy Technology Data Exchange (ETDEWEB)
Stout, R. B.; Woods, K. N. [Siemens Nuclear Power Corp., Richland, WA (United States)
1997-04-01
This paper describes the key features of the Siemens HTP (High Thermal Performance) fuel design, the current in-reactor performance of this advanced fuel assembly design, and the advanced cladding types available.
Trouillas, P
1984-09-01
A quantitative evaluation of cerebellar ataxia, with an ataxia score (total, static, kinetic) and the measurement of objective values relating to the major symptoms, was used in 21 patients with hereditary ataxias treated for 12 months with high doses (16 mg/kg/day) of d-l-5-HTP, l-5-HTP or the combination d-l-5-HTP (16 mg/kg/day)--benserazide (6 mg/kg/day). The data obtained from regular examination were processed by computer. The ataxia showed a significant regression at the 12th month, mainly in the static forms and speed of speech. l-5-HTP appeared to be more effective than d-l-5-HTP. Regression of the cerebellar ataxia was also observed in non-degenerative conditions such as multiple sclerosis and surgical lesion of the anterior lobe vermis, showing that 5-HTP was active on the cerebellar syndrome in general. The regression of the cerebellar ataxia was very slow in inherited diseases and continued for 2 or 4 months after the treatment stopped. A serotoninergic cerebellar control of movement is discussed.
High Thinking Processes (HTP): Elements of Curricula and Teaching Able-Learners.
Kaniel, Shlomo
2002-01-01
This article discusses preparing able learners for the technologically dynamic future by teaching High Thinking Processes (HTP). It describes components of HTP and four main elements for developing HTP: well organized and justified curricula with appropriate tasks; metacognitive teaching; learning communities and challenging environments; and…
Lynn-Bullock, Christina P; Welshhans, Kristy; Pallas, Sarah L; Katz, Paul S
2004-05-01
5-Hydroxytryptophan (5-HTP), which is the rate-limiting precursor in serotonin (5-hydroxytryptamine (5-HT)) biosynthesis, is used as an oral supplement to enhance serotonin levels in humans. To evaluate its effects on serotonin levels and localization, 5-hydroxytryptophan was administered to Sprague-Dawley rats either orally or via intraperitoneal injection. 5-Hydroxytryptophan-immunoreactivity was co-localized with serotonin-immunoreactivity in the serotonergic dorsal raphe nucleus of control animals and this was not changed in animals given 5-hydroxytryptophan. Oral 5-HTP administration increased the intensity of both 5-HTP and serotonin immunoreactivity in raphe neurons. However, 5-HTP treatment also caused ectopic 5-hydroxytryptophan-immunoreactivity and serotonin-immunoreactivity in normally dopaminergic neurons of the substantia nigra par compacta. Serotonin-immunoreactivity was confined to neurons that also displayed amino acid decarboxylase immunoreactivity, but in a small percentage of substantia nigra neurons, serotonin immunoreactivity was not co-localized with tyrosine hydroxylase-immunoreactivity. The intensity of the immunoreactivity to serotonin and 5-hydroxytryptophan in the substantia nigra was maximal within 2h of 5-hydroxytryptophan administration and returned to control levels by 24h. This time course mirrored changes in HPLC measurements of 5-hydroxytryptophan, serotonin, and the metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the urine. 5-Hydroxytryptophan administration did not cause ectopic appearance of either serotonin or 5-hydroxytryptophan in the noradrenergic locus coeruleus. These results suggest that a single oral dose of 5-HTP increases the 5-HTP and serotonin content of serotonergic neurons and causes the transient ectopic appearance of serotonin in some normally non-serotonergic neurons.
Expression and purification of integral membrane metallopeptidase HtpX.
Arolas, Joan L; García-Castellanos, Raquel; Goulas, Theodoros; Akiyama, Yoshinori; Gomis-Rüth, F Xavier
2014-07-01
Little is known about the catalytic mechanism of integral membrane (IM) peptidases. HtpX is an IM metallopeptidase that plays a central role in protein quality control by preventing the accumulation of misfolded proteins in the membrane. Here we report the recombinant overexpression and purification of a catalytically ablated form of HtpX from Escherichia coli. Several E. coli strains, expression vectors, detergents, and purification strategies were tested to achieve maximum yields of pure and well-folded protein. HtpX was successfully overexpressed in E. coli BL21(DE3) cells using a pET-derived vector attaching a C-terminal His8-tag, extracted from the membranes using octyl-β-d-glucoside, and purified to homogeneity in the presence of this detergent in three consecutive steps: cobalt-affinity, anion-exchange, and size-exclusion chromatography. The production of HtpX in milligram amounts paves the way for structural studies, which will be essential to understand the catalytic mechanism of this IM peptidase and related family members. Copyright © 2014 Elsevier Inc. All rights reserved.
Insight into the evolution of the histidine triad protein (HTP) family in Streptococcus.
Shao, Zhu-Qing; Zhang, Yan-Mei; Pan, Xiu-Zhen; Wang, Bin; Chen, Jian-Qun
2013-01-01
The Histidine Triad Proteins (HTPs), also known as Pht proteins in Streptococcus pneumoniae, constitute a family of surface-exposed proteins that exist in many pathogenic streptococcal species. Although many studies have revealed the importance of HTPs in streptococcal physiology and pathogenicity, little is known about their origin and evolution. In this study, after identifying all htp homologs from 105 streptococcal genomes representing 38 different species/subspecies, we analyzed their domain structures, positions in genome, and most importantly, their evolutionary histories. By further projecting this information onto the streptococcal phylogeny, we made several major findings. First, htp genes originated earlier than the Streptococcus genus and gene-loss events have occurred among three streptococcal groups, resulting in the absence of the htp gene in the Bovis, Mutans and Salivarius groups. Second, the copy number of htp genes in other groups of Streptococcus is variable, ranging from one to four functional copies. Third, both phylogenetic evidence and domain structure analyses support the division of two htp subfamilies, designated as htp I and htp II. Although present mainly in the pyogenic group and in Streptococcus suis, htp II members are distinct from htp I due to the presence of an additional leucine-rich-repeat domain at the C-terminus. Finally, htp genes exhibit a faster nucleotide substitution rate than do housekeeping genes. Specifically, the regions outside the HTP domains are under strong positive selection. This distinct evolutionary pattern likely helped Streptococcus to easily escape from recognition by host immunity.
Insight into the evolution of the histidine triad protein (HTP family in Streptococcus.
Directory of Open Access Journals (Sweden)
Zhu-Qing Shao
Full Text Available The Histidine Triad Proteins (HTPs, also known as Pht proteins in Streptococcus pneumoniae, constitute a family of surface-exposed proteins that exist in many pathogenic streptococcal species. Although many studies have revealed the importance of HTPs in streptococcal physiology and pathogenicity, little is known about their origin and evolution. In this study, after identifying all htp homologs from 105 streptococcal genomes representing 38 different species/subspecies, we analyzed their domain structures, positions in genome, and most importantly, their evolutionary histories. By further projecting this information onto the streptococcal phylogeny, we made several major findings. First, htp genes originated earlier than the Streptococcus genus and gene-loss events have occurred among three streptococcal groups, resulting in the absence of the htp gene in the Bovis, Mutans and Salivarius groups. Second, the copy number of htp genes in other groups of Streptococcus is variable, ranging from one to four functional copies. Third, both phylogenetic evidence and domain structure analyses support the division of two htp subfamilies, designated as htp I and htp II. Although present mainly in the pyogenic group and in Streptococcus suis, htp II members are distinct from htp I due to the presence of an additional leucine-rich-repeat domain at the C-terminus. Finally, htp genes exhibit a faster nucleotide substitution rate than do housekeeping genes. Specifically, the regions outside the HTP domains are under strong positive selection. This distinct evolutionary pattern likely helped Streptococcus to easily escape from recognition by host immunity.
Serotonergic mechanisms involved in the suppression of feeding by 5-HTP in rats.
Ju, C Y; Tsai, C T
1995-01-01
The effect of 5-hydroxytryptophan (5-HTP), the serotonin precursor, on food intake in rats was investigated in this study. 5-HTP (100 mg/kg, i.p.) reduced food intake by 68.9% of control level. The anorectic effect of 5-HTP was antagonized by cyproheptadine (CYP, 4 mg/kg, i.p.), a serotonin receptor blockade. However, the anorectic effect of 5-HTP was also antagonized by propranolol (PROP 1mg/kg, i.p.) and sulpiride (SULP, 20 mg/kg, i.p.), while Pinodol (PIN 2mg/kg, i.p.) and Haloperidol (HAL 0.5 mg/kg, i.p) did not affect the suppressive effect of 5-HTP on food intake by 5-HTP. These results indicates that the anorectic action of 5-HTP was mediated by the serotonergic mechanism through 5-HT1 and 5-HT2 receptors.
Kawalia, Amit; Motameny, Susanne; Wonczak, Stephan; Thiele, Holger; Nieroda, Lech; Jabbari, Kamel; Borowski, Stefan; Sinha, Vishal; Gunia, Wilfried; Lang, Ulrich; Achter, Viktor; Nürnberg, Peter
2015-01-01
Next generation sequencing (NGS) has been a great success and is now a standard method of research in the life sciences. With this technology, dozens of whole genomes or hundreds of exomes can be sequenced in rather short time, producing huge amounts of data. Complex bioinformatics analyses are required to turn these data into scientific findings. In order to run these analyses fast, automated workflows implemented on high performance computers are state of the art. While providing sufficient compute power and storage to meet the NGS data challenge, high performance computing (HPC) systems require special care when utilized for high throughput processing. This is especially true if the HPC system is shared by different users. Here, stability, robustness and maintainability are as important for automated workflows as speed and throughput. To achieve all of these aims, dedicated solutions have to be developed. In this paper, we present the tricks and twists that we utilized in the implementation of our exome data processing workflow. It may serve as a guideline for other high throughput data analysis projects using a similar infrastructure. The code implementing our solutions is provided in the supporting information files.
Directory of Open Access Journals (Sweden)
Amit Kawalia
Full Text Available Next generation sequencing (NGS has been a great success and is now a standard method of research in the life sciences. With this technology, dozens of whole genomes or hundreds of exomes can be sequenced in rather short time, producing huge amounts of data. Complex bioinformatics analyses are required to turn these data into scientific findings. In order to run these analyses fast, automated workflows implemented on high performance computers are state of the art. While providing sufficient compute power and storage to meet the NGS data challenge, high performance computing (HPC systems require special care when utilized for high throughput processing. This is especially true if the HPC system is shared by different users. Here, stability, robustness and maintainability are as important for automated workflows as speed and throughput. To achieve all of these aims, dedicated solutions have to be developed. In this paper, we present the tricks and twists that we utilized in the implementation of our exome data processing workflow. It may serve as a guideline for other high throughput data analysis projects using a similar infrastructure. The code implementing our solutions is provided in the supporting information files.
Gostowski, Rudy; Villegas, Yvonne; Nwosisi, Genne
2003-01-01
High-Test Hydrogen Peroxide (HTP) propellant (greater than or equal to 70%) offers many advantages in space launch applications; however, materials used in construction of propulsion systems must be shown to be compatible with HTP. Isothermal Microcalorimetry (IMC) was used to determine the compatibility of several metallic and non-metallic materials with 90% HTP. The results of these experiments agreed with those from immersion bath tests when the values were converted to %Active Oxygen Loss per week (%AOL/wk).
Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin.
Nakamura, Kazuhiro; Hasegawa, Hiroyuki
2009-01-01
Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the synthesis of 5-hydroxy-L-tryptophan (5-HTP) from L-tryptophan. This step is dictated by an enzyme, tryptophan hydroxylase (TPH). TPH requires 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as a co-substrate of TPH. 5-HTP has been simply regarded as a precursor of 5-HT and it is believed that the biological significance of 5-HTP is essentially ascribed to the production of 5-HT. However, recent works shed light on the specific functions of 5-HTP in the periphery. In this review article, we focus on the specific roles of exogenous 5-HTP as well as the endogenous 5-HTP in the gut epithelial cells. Since systemic treatment with 5-HTP is applied to patients with lower 5-HT levels, the studies on the specific role of 5-HTP might create an opportunity to explore the effects of exogenously-applied 5-HTP in the gut in man.
Noll, K M; Wolfe, R S
1986-09-30
The structure of component B of the methylcoenzyme M methylreductase system of Methanobacterium thermoautotrophicum was recently found to be 7-mercaptoheptanoylthreonine phosphate (HS-HTP). The work described here demonstrates that this compound is found in two forms: enzyme-free and enzyme-bound. HS-HTP was found to be bound to component C of the methylcoenzyme M methylreductase system. The cofactor extracted from the protein by heat denaturation was found to comigrate with the mixed disulfide of HS-HTP and 2-mercaptoethanol by high-performance liquid chromatography, suggesting HS-HTP is not modified in the bound state.
Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin
Directory of Open Access Journals (Sweden)
Kazuhiro Nakamura
2009-01-01
Full Text Available Serotonin (5-hydroxytryptamine [5-HT] has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the synthesis of 5-hydroxy-L-tryptophan (5-HTP from L-tryptophan. This step is dictated by an enzyme, tryptophan hydroxylase (TPH. TPH requires 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 as a co-substrate of TPH. 5-HTP has been simply regarded as a precursor of 5-HT and it is believed that the biological significance of 5-HTP is essentially ascribed to the production of 5-HT. However, recent works shed light on the specific functions of 5-HTP in the periphery. In this review article, we focus on the specific roles of exogenous 5-HTP as well as the endogenous 5-HTP in the gut epithelial cells. Since systemic treatment with 5-HTP is applied to patients with lower 5-HT levels, the studies on the specific role of 5-HTP might create an opportunity to explore the effects of exogenously-applied 5-HTP in the gut in man.
Generalised twisted partition functions
Petkova, V B
2001-01-01
We consider the set of partition functions that result from the insertion of twist operators compatible with conformal invariance in a given 2D Conformal Field Theory (CFT). A consistency equation, which gives a classification of twists, is written and solved in particular cases. This generalises old results on twisted torus boundary conditions, gives a physical interpretation of Ocneanu's algebraic construction, and might offer a new route to the study of properties of CFT.
Casey, E. J.; Commadore, C. C.; Ingles, M. E.
1980-01-01
Long wire bundles twist into uniform spiral harnesses with help of simple apparatus. Wires pass through spacers and through hand-held tool with hole for each wire. Ends are attached to low speed bench motor. As motor turns, operator moves hand tool away forming smooth twists in wires between motor and tool. Technique produces harnesses that generate less radio-frequency interference than do irregularly twisted cables.
Twisted network programming essentials
Fettig, Abe
2005-01-01
Twisted Network Programming Essentials from O'Reilly is a task-oriented look at this new open source, Python-based technology. The book begins with recommendations for various plug-ins and add-ons to enhance the basic package as installed. It then details Twisted's collection simple network protocols, and helper utilities. The book also includes projects that let you try out the Twisted framework for yourself. For example, you'll find examples of using Twisted to build web services applications using the REST architecture, using XML-RPC, and using SOAP. Written for developers who want to s
L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice
Institute of Scientific and Technical Information of China (English)
Jian-hui LIANG; Jun-xu LI; Xu-hua WANG; Bi CHEN; Ying LU; Pan ZHANG; Rong HAN; Xiang-feng YE
2004-01-01
AIM: To investigate the involvement of L-type Ca2+ channels in antinociceptive action induced by the 5-HT precursor,5-hydroxytryptophan (5-HTP). METHODS: Female Kunming mice were treated with either 5-HTP (20-80 mg/kg,ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2.5-10 mg/kg, ip), CaC12 (5-20 mmol/L, icv), or EGTA (0.5-3 mmol/L, icv) prior to the hot-plate test (55 ℃, hind-paw licking latency). In addition, locomotor activity in mice treated with 5-HTP alone was measured using an ambulometer with five activity boxes. RESULTS: Ip injection of 5-HTP alone had no influence on the spontaneous locomotor activity, whereas dose-dependently increased the latency to licking hind-paw in the hot-plate test in mice. The inhibitory effects of 5-HTP on nociceptive response were significantly enhanced by fluoxetine in the mouse hot-plate test. At a sub-effective dose, pargyline could cause a leftward shift in the dose-response curve of 5-HTP-induced antinociception. Co-administration with 5-HTP and nimodipine, nifedipine, or verapamil obviously potentiated the antinociceptive effects elicited by 5-HTP.Interestingly, 5-HTP-induced antinociception was antagonized by CaC12 and enhanced by EGTA injected icv in the mouse hot-plate test. CONCLUSION: These findings suggest that systemic administration of 5-HTP may yield the antinociceptive effects, which are related to Ca2+ influx from extracellular fluid through L-type Ca2+ channels.
L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice.
Liang, Jian-hui; Li, Jun-xu; Wang, Xu-hua; Chen, Bi; Lu, Ying; Zhang, Pan; Han, Rong; Ye, Xiang-feng
2004-05-01
To investigate the involvement of L-type Ca(2+) channels in antinociceptive action induced by the 5-HT precursor, 5-hydroxytryptophan (5-HTP). Female Kunming mice were treated with either 5-HTP (20-80 mg/kg, ip) alone, or the combination of 5-HTP and fluoxetine (2-8 mg/kg, ip), pargyline (15-60 mg/kg, ip), nimodipine (2.5-10 mg/kg, ip), nifedipine (2.5-10 mg/kg, ip), verapamil (2.5-10 mg/kg, ip), CaCl(2) (5-20 mmol/L, icv), or EGTA (0.5-3 mmol/L, icv) prior to the hot-plate test (55 degree, hind-paw licking latency). In addition, locomotor activity in mice treated with 5-HTP alone was measured using an ambulometer with five activity boxes. Ip injection of 5-HTP alone had no influence on the spontaneous locomotor activity, whereas dose-dependently increased the latency to licking hind-paw in the hot-plate test in mice. The inhibitory effects of 5-HTP on nociceptive response were significantly enhanced by fluoxetine in the mouse hot-plate test. At a sub-effective dose, pargyline could cause a leftward shift in the dose-response curve of 5-HTP-induced antinociception. Co-administration with 5-HTP and nimodipine, nifedipine, or verapamil obviously potentiated the antinociceptive effects elicited by 5-HTP. Interestingly, 5-HTP-induced antinociception was antagonized by CaCl(2) and enhanced by EGTA injected icv in the mouse hot-plate test. These findings suggest that systemic administration of 5-HTP may yield the antinociceptive effects, which are related to Ca(2+) influx from extracellular fluid through L-type Ca(2+) channels.
Overregularity in Oliver Twist
Institute of Scientific and Technical Information of China (English)
孔祥曼
2015-01-01
Oliver Twist is one of the earliest works of Charles Dickens. In this novel, the author uses many writing skills which impress the readers a lot. This paper gives a brief description of overregularity in Oliver Twist at the phonological and syntactical levels.
Twisted exponential sums of polynomials in one variable
Institute of Scientific and Technical Information of China (English)
无
2010-01-01
The twisted T-adic exponential sums associated to a polynomial in one variable are studied.An explicit arithmetic polygon in terms of the highest two exponents of the polynomial is proved to be a lower bound of the Newton polygon of the C-function of the twisted T-adic exponential sums.This bound gives lower bounds for the Newton polygon of the L-function of twisted p-power order exponential sums.
Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models.
Hong, Ki-Bae; Park, Yooheon; Suh, Hyung Joo
2016-09-01
The aim of this study was to investigate the sleep-promoting effect of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality and quantity in vertebrate models. Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of two amino acids and GABA/5-HTP mixture. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. The GABA/5-HTP mixture significantly regulated the sleep latency, duration (pHTP mixture modulates both GABAergic and serotonergic signaling. Moreover, the sleep architecture can be controlled by the regulation of GABAA receptor and GABA content with 5-HTP.
Effect of hypothalamic surgery on prolactin release induced by 5-hydroxytryptophan (5-HTP) in rats.
Ohgo, S; Kato, Y; Chihara, K; Imura, H; Maeda, K
1976-12-01
Intravenous injections of varying doses of 5-HTP (1, 3 and 5 mg/100 g body wt), a precursor of serotonin, caused a significant and dose-related increase in plasma prolactin concentrations in urethane-anesthetized rats. Increases in plasma prolactin concentrations caused by 5-HTP (1 mg/100 g body wt iv) were abolished by the concomitant administration of L-DOPA (2 mg/100 g body wt iv). Plasma prolactin levels were also significantly elevated following the injection of 5-HTP in rats with complete hypothalamic deafferentation, whereas 5-HTP had no significant effect on plasma prolactin levels in rats with extensive hypothalamic ablation. These results suggest that 5-HTP causes prolactin secretion by stimulating the serotoninergic mechanism in the hypothalamus.
Freed, Daniel S
2012-01-01
We show how general principles of symmetry in quantum mechanics lead to twisted notions of a group representation. This framework generalizes both the classical 3-fold way of real/complex/quaternionic representations as well as a corresponding 10-fold way which has appeared in condensed matter and nuclear physics. We establish a foundation for discussing continuous families of quantum systems. Having done so, topological phases of quantum systems can be defined as deformation classes of continuous families of gapped Hamiltonians. For free particles there is an additional algebraic structure on the deformation classes leading naturally to notions of twisted equivariant K-theory. In systems with a lattice of translational symmetries we show that there is a canonical twisting of the equivariant K-theory of the Brillouin torus. We give precise mathematical definitions of two invariants of the topological phases which have played an important role in the study of topological insulators. Twisted equivariant K-theor...
Institute of Scientific and Technical Information of China (English)
MATHAI; Varghese
2010-01-01
We review the Reidemeister, Ray-Singer’s analytic torsion and the Cheeger-Mller theorem. We describe the analytic torsion of the de Rham complex twisted by a flux form introduced by the current authors and recall its properties. We define a new twisted analytic torsion for the complex of invariant differential forms on the total space of a principal circle bundle twisted by an invariant flux form. We show that when the dimension is even, such a torsion is invariant under certain deformation of the metric and the flux form. Under T-duality which exchanges the topology of the bundle and the flux form and the radius of the circular fiber with its inverse, the twisted torsion of invariant forms are inverse to each other for any dimension.
Mathai, Varghese
2009-01-01
We review the Reidemeister and Ray-Singer's analytic torsions and the Cheeger-M"uller theorem. We describe the analytic torsion of the de Rham complex twisted by a flux form introduced by the current authors and recall its properties. We define a new twisted analytic torsion for the complex of invariant differential forms on the total space of a principal circle bundle twisted by an invariant flux form. We show that when the dimension is even, such a torsion is invariant under certain deformation of the metric and the flux form. Under T-duality which exchanges the topology of the bundle and the flux form and the radius of the circular fiber with its inverse, the twisted torsions are inverse to each other for any dimensions.
On the commutator length of a Dehn twist
Szepietowski, Blazej
2010-01-01
We show that on a nonorientable surface of genus at least 7 any power of a Dehn twist is equal to a single commutator in the mapping class group and the same is true, under additional assumptions, for the twist subgroup, and also for the extended mapping class group of an orientable surface of genus at least 3.
Twisted radio waves and twisted thermodynamics.
Kish, Laszlo B; Nevels, Robert D
2013-01-01
We present and analyze a gedanken experiment and show that the assumption that an antenna operating at a single frequency can transmit more than two independent information channels to the far field violates the Second Law of Thermodynamics. Transmission of a large number of channels, each associated with an angular momenta 'twisted wave' mode, to the far field in free space is therefore not possible.
Behavioral, neuroendocrine and biochemical effects of different doses of 5-HTP in panic disorder.
van Vliet, I M; Slaap, B R; Westenberg, H G; Den Boer, J A
1996-05-01
To investigate the role of serotonin (5-HT) in the pathophysiology of panic disorder (PD) a challenge test with L-5-hydroxytryptophan (5-HTP) was conducted. Seven patients suffering from PD and seven healthy controls received an i.v. challenge with 10 mg, 20 mg and 40 mg 5-HTP and placebo in random order on four different occasions. Before, during and until 2 h after 5-HTP administration anxious and depressive symptomatology was assessed. In addition, plasma levels of 5-HTP, cortisol, and 5-HIAA were measured at several timepoints. During and after infusion of placebo or any of the different dosages of 5-HTP, none of the patients or controls experienced a panic attack or showed an increase in anxiety or depressive symptoms. There was a dose-related increase in side effects, like nausea, dizziness and fatigue. Only infusion with 40 mg 5-HTP led to an increase in plasma cortisol in both patients and controls. The observed increase in plasma cortisol level was higher for patients compared to controls only at 30 min after infusion. In conclusion, stimulation of the serotonergic neuronal system by three different dosages of 5-HTP did not induce panic or anxiety in PD patients and healthy controls. The 5-HT hypersensitivity hypothesis of PD could not be confirmed in the present study.
Blossier, B; De soto, F; Morenas, V; Gravina, M; Pène, O; Rodríguez-Quintero, J
2010-01-01
A non-perturbative calculation of the ghost-gluon running QCD coupling constant is performed using $N_f=2$ twisted-mass dynamical fermions. The extraction of $\\Lambda_{\\bar{MS}}$ in the chiral limit reveals the presence of a non-perturbative OPE contribution that is assumed to be dominated by a dimension-two $\\VEV{A^2}$ condensate. In this contest a novel method for calibrating the lattice spacing in lattice simulations is presented.
Twisted derivations of Hopf algebras
Davydov, Alexei
2012-01-01
In the paper we introduce the notion of twisted derivation of a bialgebra. Twisted derivations appear as infinitesimal symmetries of the category of representations. More precisely they are infinitesimal versions of twisted automorphisms of bialgebras. Twisted derivations naturally form a Lie algebra (the tangent algebra of the group of twisted automorphisms). Moreover this Lie algebra fits into a crossed module (tangent to the crossed module of twisted automorphisms). Here we calculate this crossed module for universal enveloping algebras and for the Sweedler's Hopf algebra.
Hong, Miao; Chen, Eugene Y-X
2014-10-27
A new polymerization termed proton (H)-transfer polymerization (HTP) has been developed to convert dimethacrylates to unsaturated polyesters. HTP is catalyzed by a selective N-heterocyclic carbene capable of promoting intermolecular Umpolung condensation through proton transfer and proceeds through the step-growth propagation cycles via enamine intermediates. The role of the added suitable phenol, which is critical for achieving an effective HTP, is twofold: shutting down the radically induced chain-growth addition polymerization under HTP conditions (typically at 80-120 °C) and facilitating proton transfer after each monomer enchainment. The resulting unsaturated polyesters have a high thermal stability and can be readily cross-linked to robust polyester materials. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The effect of DL-5-hydroxytryptophan (5-HTP) on plasma prolactin in pituitary stalk sectioned rats.
Akabori, A; Araki, S; Tamada, T
1981-08-01
5-HTP (5 mg/100 g body weight), a precursor of serotonin, was administered intravenously to pituitary stalk sectioned rats. Plasma prolactin levels were initially increased 30 and 60 min after the injection of 5-HTP and thereafter decreased. Pituitary prolactin content was decreased 60 min after the stalk section as compared to those seen following sham operation. The treatment of 5-HTP induced a moderate increase in pituitary prolactin content in the stalk sectioned rats. In order to confirm the complete disconnection of pituitary stalk after the operation, 2.5 micrograms of dopamine hydrochloride was given into the lateral ventricle of stalk sectioned rats. Plasma prolactin did not change following the administration. Our results demonstrate that 5-HTP acts either directly at the pituitary level or via some mechanism yet to be determined.
Evaluation of MBEC™‐HTP biofilm model for studies of implant associated infections
National Research Council Canada - National Science Library
Coraça‐Hubér, Debora C; Fille, Manfred; Hausdorfer, Johann; Pfaller, Kristian; Nogler, Michael
2012-01-01
.... Staphylococcus aureus and Staphylococcus epidermidis biofilms were grown on MBEC™‐HTP. To ensure the biofilm formation, antibiotic susceptibility tests and scanning electron microscopy (SEM) was carried out...
Zabik, J E; Sprague, J E; Binkerd, K
1994-03-01
When administered under a backward conditioning paradigm, 5-HTP administration resulted in a decrease in ethanol intake followed by a persistently decreased ethanol consumption. A central component to this inhibitory effect was suggested by the inability of xylamidine to significantly reduce the initial inhibitory effect of 5-HTP. The persistent rejection was prevented by xylamidine. Methysergide reduced the initial as well as the persistent effects of 5-HTP. In studies utilizing a forward conditioning paradigm, 5-HTP and lithium were each effective in developing CTAs to ethanol and saccharin. Only the ethanol-5-HTP pairing showed a persistent aversion. A peripheral component to the actions of 5-HTP was suggested by xylamidine blocking the CTAs induced by 5-HTP. Xylamidine also prevented the persistent ethanol avoidance induced by 5-HTP, but was ineffective in antagonizing lithium-induced CTAs. These results suggest central as well as peripheral components associated with the inhibitory effects of 5-HTP on ethanol consumption. Central actions appear to mediate the initial inhibitory effects while peripheral actions appear to be associated with persistent avoidance of ethanol following 5-HTP treatment.
Comparison of effects of Idazoxan and 5-HTP on anxiety with Chlordiazepoxide
Alaiy H; Hajiamiri R
1997-01-01
We studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-HTP) on anxiety-related behavior in rats. The conflict drinking test, and evaluator plus-maze were used as model. Idazoxan (2 mg/kg) showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-HTP showed that anxiolytic-like effect in both models. This drug reversed action and produced anxiogenic-like effect at high doses. In contrast, arecholine which ...
DEFF Research Database (Denmark)
Yiu, Man Lung; Jensen, Christian Søndergaard; Xuegang, Huang
2008-01-01
-based matching generally fall short in offering practical query accuracy guarantees. Our proposed framework, called SpaceTwist, rectifies these shortcomings for k nearest neighbor (kNN) queries. Starting with a location different from the user's actual location, nearest neighbors are retrieved incrementally...
Reweighting twisted boundary conditions
Bussone, Andrea; Hansen, Martin; Pica, Claudio
2015-01-01
Imposing twisted boundary conditions on the fermionic fields is a procedure extensively used when evaluating, for example, form factors on the lattice. Twisting is usually performed for one flavour and only in the valence, and this causes a breaking of unitarity. In this work we explore the possibility of restoring unitarity through the reweighting method. We first study some properties of the approach at tree level and then we stochastically evaluate ratios of fermionic determinants for different boundary conditions in order to include them in the gauge averages, avoiding in this way the expensive generation of new configurations for each choice of the twisting angle, $\\theta$. As expected the effect of reweighting is negligible in the case of large volumes but it is important when the volumes are small and the twisting angles are large. In particular we find a measurable effect for the plaquette and the pion correlation function in the case of $\\theta=\\pi/2$ in a volume $16\\times 8^3$, and we observe a syst...
Wang, Zuoqin
2007-01-01
The "twisted Mellin transform" is a slightly modified version of the usual classical Mellin transform on $L^2(\\mathbb R)$. In this short note we investigate some of its basic properties. From the point of views of combinatorics one of its most important interesting properties is that it intertwines the differential operator, $df/dx$, with its finite difference analogue, $\
On the performance analysis of Savonius rotor with twisted blades
Energy Technology Data Exchange (ETDEWEB)
Saha, U.K.; Rajkumar, M. Jaya [Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati-781 039 (India)
2006-09-15
The present investigation is aimed at exploring the feasibility of twisted bladed Savonius rotor for power generation. The twisted blade in a three-bladed rotor system has been tested in a low speed wind tunnel, and its performance has been compared with conventional semicircular blades (with twist angle of 0{sup o}). Performance analysis has been made on the basis of starting characteristics, static torque and rotational speed. Experimental evidence shows the potential of the twisted bladed rotor in terms of smooth running, higher efficiency and self-starting capability as compared to that of the conventional bladed rotor. Further experiments have been conducted in the same setup to optimize the twist angle. (author)
Gostowski, Rudy; Villegas, Yvonne; Nwosisi, Genne; Rodgers, Stephen L. (Technical Monitor)
2002-01-01
High-Test Hydrogen Peroxide (HTP) propellant (equal to or greater than 70%) offers many advantages in space launch applications. However, materials used in construction of propulsion systems must be shown to be compatible with HTP. Isothermal Microcalorimetry (IMC) was used to determine the compatibility of several metallic and non-metallic materials with 90% HTP. The results of these experiments agreed with those from immersion bath tests when the values were converted to % Active Oxygen Loss per week (%AOL/wk).
Aeromechanical Evaluation of Smart-Twisting Active Rotor
Lim, Joon W.; Boyd, D. Douglas, Jr.; Hoffman, Frauke; van der Wall, Berend G.; Kim, Do-Hyung; Jung, Sung N.; You, Young H.; Tanabe, Yasutada; Bailly, Joelle; Lienard, Caroline; Delrieux, Yves
2014-01-01
An investigation of Smart-Twisting Active Rotor (STAR) was made to assess potential benefits of the current active twist rotor concept for performance improvement, vibration reduction, and noise alleviation. The STAR rotor is a 40% Mach-scaled, Bo105 rotor with an articulated flap-lag hinge at 3.5%R and no pre-cone. The 0-5 per rev active twist harmonic inputs were applied for various flight conditions including hover, descent, moderate to high speed level flights, and slowed rotor high advance ratio. For the analysis, the STAR partners used multiple codes including CAMRAD II, S4, HOST, rFlow3D, elsA, and their associated software. At the high thrust level in hover, the 0 per rev active twist with 80% amplitude increased figure of merit (FM) by 0.01-0.02 relative to the baseline. In descent, the largest BVI noise reduction was on the order of 2 to 5 dB at the 3 per rev active twist. In the high speed case (mu = 0.35), the 2 per rev actuation was found to be the most effective in achieving a power reduction as well as a vibration reduction. At the 2 per rev active twist, total power was reduced by 0.65% at the 60 deg active twist phase, and vibration was reduced by 47.6% at the 45 deg active twist phase. The use of the 2 per rev active twist appears effective for vibration reduction. In the high advance ratio case (mu = 0.70), the 0 per rev actuation appeared to have negligible impact on performance improvement. In summary, computational simulations successfully demonstrated that the current active twist concept provided a significant reduction of the maximum BVI noise in descent, a significant reduction of the vibration in the high speed case, a small improvement on rotor performance in hover, and a negligible impact on rotor performance in forward flight.
Blossier, B; De soto, F; Morenas, V; Gravina, M; Pène, O; Rodríguez-Quintero, J
2010-01-01
We present results concerning the non-perturbative evaluation of the ghost-gluon running QCD coupling constant from $N_f=2$ twisted-mass lattice calculations. A novel method for calibrating the lattice spacing, independent of the string tension and hadron spectrum is presented with results in agreement with previous estimates. The value of $\\Lambda_{\\overline{MS}}$ is computed from the running of the QCD coupling only after extrapolating to zero dynamical quark mass and after removing a non-perturbative OPE contribution that is assumed to be dominated by the dimension-two $\\VEV{A^2}$ gluon condensate. The effect due to the dynamical quark mass in the determination of $\\Lams$ is discussed.
Martinez-Perez, Enrique; Villeneuve, Anne M
2005-11-15
Synaptonemal complex (SC) assembly must occur between correctly paired homologous chromosomes to promote formation of chiasmata. Here, we identify the Caenorhabditis elegans HORMA-domain protein HTP-1 as a key player in coordinating establishment of homolog pairing and synapsis in C. elegans and provide evidence that checkpoint-like mechanisms couple these early meiotic prophase events. htp-1 mutants are defective in the establishment of pairing, but in contrast with the pairing-defective chk-2 mutant, SC assembly is not inhibited and generalized nonhomologous synapsis occurs. Extensive nonhomologous synapsis in htp-1; chk-2 double mutants indicates that HTP-1 is required for the inhibition of SC assembly observed in chk-2 gonads. htp-1 mutants show a decreased abundance of nuclei exhibiting a polarized organization that normally accompanies establishment of pairing; analysis of htp-1; syp-2 double mutants suggests that HTP-1 is needed to prevent premature exit from this polarized nuclear organization and that this exit stops homology search. Further, based on experiments monitoring the formation of recombination intermediates and crossover products, we suggest that htp-1 mutants are defective in preventing the use of sister chromatids as recombination partners. We propose a model in which HTP-1 functions to establish or maintain multiple constraints that operate to ensure coordination of events leading to chiasma formation.
Aliño, J J; Gutierrez, J L; Iglesias, M L
1976-01-01
Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo). The patients treated with nialamide + l-5-HTP achieved a fuller recovery than those who were treated with nialamide alone. The treatment with nialamide + l-5-HTP proved to have a shorter delay of onset. Side effects showed no marked differences except for the orthostatic hypotension which was less apparent in those patients treated with nialamide + l-5-HTP.
Nasrallah, Gheyath K; Gagnon, Elizabeth; Orton, Dennis J; Garduño, Rafael A
2011-11-01
HtpB, the chaperonin of the intracellular bacterial pathogen Legionella pneumophila , displays several virulence-related functions in vitro. To confirm HtpB's role in vivo, host infections with an htpB deletion mutant would be required. However, we previously reported that the htpAB operon (encoding co-chaperonin and chaperonin) is essential. We attempted here to delete htpAB in a L. pneumophila strain carrying the groE operon (encoding the Escherichia coli co-chaperonin and chaperonin). The groE operon was inserted into the chromosome of L. pneumophila Lp02, and then allelic replacement of htpAB with a gentamicin resistance cassette was attempted. Although numerous potential postallelic replacement transformants showed a correct selection phenotype, we still detected htpAB by PCR and full-size HtpB by immunoblot. Southern blot and PCR analysis indicated that the gentamicin resistance cassette had apparently integrated in a duplicated htpAB region. However, we showed by Southern blot that strain Lp02, and the Lp02 derivative carrying the groE operon, have only one copy of htpAB. These results confirmed that the htpAB operon cannot be deleted, not even in the presence of the groE operon, and suggested that attempts to delete htpAB under strong phenotypic selection result in aberrant genetic recombinations that could involve duplication of the htpAB locus.
Cui, Xiaoyan; Rohl, Andrew L; Shtukenberg, Alexander; Kahr, Bart
2013-03-06
Banded spherulites of aspirin have been crystallized from the melt in the presence of salicylic acid either generated from aspirin decomposition or added deliberately (2.6-35.9 mol %). Scanning electron microscopy, X-ray diffraction analysis, and optical polarimetry show that the spherulites are composed of helicoidal crystallites twisted along the growth directions. Mueller matrix imaging reveals radial oscillations in not only linear birefringence, but also circular birefringence, whose origin is explained through slight (∼1.3°) but systematic splaying of individual lamellae in the film. Strain associated with the replacement of aspirin molecules by salicylic acid molecules in the crystal structure is computed to be large enough to work as the driving force for the twisting of crystallites.
Directory of Open Access Journals (Sweden)
Daijiro Fukuda
2004-01-01
Full Text Available Using diagrammatic pictures of tensor contractions, we consider a Hopf algebra (Aop⊗ℛλA** twisted by an element ℛλ∈A*⊗Aop corresponding to a Hopf algebra morphism λ:A→A. We show that this Hopf algebra is quasitriangular with the universal R-matrix coming from ℛλ when λ2=idA, generalizing the quantum double construction which corresponds to the case λ=idA.
Vranish, John M. (Inventor)
1996-01-01
A planetary gear system includes a sun gear coupled to an annular ring gear through a plurality of twist-planet gears, a speeder gear, and a ground structure having an internal ring gear. Each planet gear includes a solid gear having a first half portion in the form of a spur gear which includes vertical gear teeth and a second half portion in the form of a spur gear which includes helical gear teeth that are offset from the vertical gear teeth and which contact helical gear teeth on the speeder gear and helical gear teeth on the outer ring gear. One half of the twist planet gears are preloaded downward, while the other half are preloaded upwards, each one alternating with the other so that each one twists in a motion opposite to its neighbor when rotated until each planet gear seats against the sun gear, the outer ring gear, the speeder gear, and the inner ring gear. The resulting configuration is an improved stiff anti-backlash gear system.
HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
Goodyer, William; Kaitna, Susanne; Couteau, Florence; Ward, Jordan D; Boulton, Simon J; Zetka, Monique
2008-02-01
Repair of the programmed meiotic double-strand breaks (DSBs) that initiate recombination must be coordinated with homolog pairing to generate crossovers capable of directing chromosome segregation. Chromosome pairing and synapsis proceed independently of recombination in worms and flies, suggesting a paradoxical lack of coregulation. Here, we find that the meiotic axis component HTP-3 links DSB formation with homolog pairing and synapsis. HTP-3 forms complexes with the DSB repair components MRE-11/RAD-50 and the meiosis-specific axis component HIM-3. Loss of htp-3 or mre-11 recapitulates meiotic phenotypes consistent with a failure to generate DSBs, suggesting that HTP-3 associates with MRE-11/RAD-50 in a complex required for meiotic DSB formation. Loss of HTP-3 eliminates HIM-3 localization to axes and HIM-3-dependent homolog alignment, synapsis, and crossing over. Our study reveals a mechanism for coupling meiotic DSB formation with homolog pairing through the essential participation of an axis component with complexes mediating both processes.
Thee effect of 5-HTP on the reproductive timer in the male cricket.
Ureshi, M; Dainobu, M; Sakai, M
2004-01-01
The post-copulatory sexually refractory stage in the male cricket Gryllus bimaculatus consists of the two substages: the first refractory stage (RS1, time-variable) between copulation and spermatophore preparation, and the second refractory stage (RS2, time-constant) between spermatophore preparation and the recommencement of courtship. To understand the mechanism of the timer for RS2, subcuticular or intraganglionic injection of biogenic amines (10(-2) mol l(-1)) was performed immediately after spermatophore preparation. RS2 was shortened by octopamine, 5-HT, 5-HTP and NA-5-HT. Among these, 5-HTP was most potent. It shortened RS2 to maximally about 38% of the control. The shortening effect continued for 4.5 h after subcuticular injection even when the hemolymph was washed out with saline at 1 hour after injection. Simultaneous injection of 5-HTP with the inhibitor (NSD-1015) of 5-HT synthesis enzyme nullified the effect of 5-HTP, indicating that the shortening effect was caused by 5-HT synthesized from extrinsic 5-HTP. Injection of the inhibitor (CHX) of protein synthesis had no effect of on RS2. These results suggest that the reproductive timer in the TAG may be controlled by 5-HT or a second messenger mediated by 5-HT.
Oluyomi, A O; Datla, K P; Curzon, G
1997-03-01
The effects of the (+) and (-) enantiomers of the antidepressant drug tianeptine (5, 10, 20 mg/kg, i.p.) on wet dog shakes (WDS) and faecal pellet production induced by concurrently administered 5-hydroxytryptophan (5-HTP, 100 mg/kg, i.p.) given 30 min after carbidopa (25 mg/kg, i.p.) were investigated in rats. WDS scores peaked approximately 1 hr after giving 5-HTP and gradually declined over the next 2 hr. (-)-Tianeptine dose-dependently and significantly inhibited WDS. Inhibition became less marked with time after administration, but remained significant over the 3 hr period after the 10 and 20 mg/kg doses and during the first 40 min after the 5 mg/kg dose. (+)-Tianeptine caused slight inhibition without dose-dependence and slightly increased net inhibition when added to the (-) isomer (10 mg/kg). The induction of faecal pellet production by 5-HTP was significantly and dose-dependently inhibited by (-)-tianeptine. The (+) isomer neither altered this effect of 5-HTP nor its inhibition by (-)-tianeptine. Results show that inhibition of 5-HTP-induced WDS and faecal pellet formation by tianeptine was almost completely dependent on the (-) isomer.
Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
Takahashi, S; Takahashi, R; Masumura, I; Miike, A
1976-01-01
L-5-hydroxytryptophan (L-5-HTP), and immediate serotonin precursor, was given to the hospitalized depressed patients in an open clinical trial of the Phase 2 study for antidepressive effects of the agent. A relatively small dose, 150 mg orally for seven days, was employed, and seven of 14 patients responded to the treatment with mild or moderate amelioration of their depressive symptoms. Urinary excretion levels and plasma concentrations of three 5-hydroxyindole compounds, 5-HTP, 5-HT and 5-HIAA, were measured during the drug treatment. Approximately 70% of the orally administered dose of L-5-HTP was recovered from the urine of depressed patients. Major part of urinary indoleamine metabolites was free and conjugate 5-HIAA. Excretion levels of these compounds in urine were not consistently altered in the depressed patients as compared to those in normal subjects. Clinical response to L-5-HTP treatment appeared to have some correlation with the biochemical measures in the depressed patients, that is, non-responders exhibited significantly lower excretion levels of 5-HT and 5-HIAA in urine, and lower plasma levels of 5-HT than responders. Administered L-5-HTP may not be fully utilized in the depressed patients who did not react to the agent.
Dehn twists and free subgroups of symplectic mapping class groups
Keating, Ailsa
2012-01-01
Given two Lagrangian spheres in an exact symplectic manifold, we find conditions under which the Dehn twists about them generate a free non-abelian subgroup of the symplectic mapping class group. This extends a result of Ishida for Riemann surfaces. The proof generalises the categorical version of Seidel's long exact sequence to arbitrary powers of a fixed Dehn twist. We also show that the Milnor fibre of any isolated degenerate hypersurface singularity contains such pairs of spheres.
5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain.
Kitahama, K; Jouvet, A; Fujimiya, M; Nagatsu, I; Arai, R
2002-05-01
This study reports the presence of noradrenergic (NA) neurons which are capable to take up 5-hydroxytryptophan (5-HTP) and decarboxylate it to 5-hydroxytryptamine (5-HT serotonin) in the kitten brain. After loading of 5-HTP and monoamine oxidase inhibitor (MAOI), we could demonstrate 5-HT-immunoreactivity (IR) not only in hypothalamic and midbrain dopaminergic (DA) cell bodies, but also in NA ones located in the pons and medulla oblongata of the new born kitten aged from 1 to 7 days. NA cell bodies could no longer show 5-HT-IR after this treatment in the kitten older than 1 month. On the other hand, 5-HT-IR in the ventrolateral posterior hypothalamic (VLPH) cells was very weak at birth and became more and more intense after 15 days of age. Finally, after loading of tryptophan (TP) and MAOI, 5-HTP uptake cells mentioned above did not express 5-HT-IR in the kitten brain.
The Gravitational Field of a Twisted Skyrmion
Hadi, Miftachul; Husein, Andri
2015-01-01
We study nonlinear sigma model, especially Skyrme model without twist and Skyrme model with twist: twisted Skyrme model. Twist term, $mkz$, is indicated in vortex solution. We are interested to construct a space-time containing a string with Lagrangian plus a twist. To add gravity, we replace $\\eta^{\\mu\
Properties of twisted ferromagnetic filaments
Energy Technology Data Exchange (ETDEWEB)
Belovs, Mihails; Cebers, Andrejs [University of Latvia, Zellu 8, LV-1002 (Latvia)], E-mail: aceb@tesla.sal.lv
2009-02-01
The full set of equations for twisted ferromagnetic filaments is derived. The linear stability analysis of twisted ferromagnetic filament is carried out. Two different types of the buckling instability are found - monotonous and oscillatory. The first in the limit of large twist leads to the shape of filament reminding pearls on the string, the second to spontaneous rotation of the filament, which may constitute the working of chiral microengine.
Striatal dopamine terminals release serotonin after 5-HTP pretreatment: in vivo voltammetric data.
Stamford, J A; Kruk, Z L; Millar, J
1990-05-07
Peripheral administration of 5-hydroxytryptophan (5-HTP) to rats causes 'wet dog' shakes and a parallel elevation of brain serotonin (5-HT) levels. The increase in 5-HT concentration does not, however, correlate with the endogenous 5-HT innervation raising the possibility that some 5-HTP is decarboxylated in non-serotonergic cells. In the present study we used in vivo voltammetry to establish whether 5-HTP treatment led to formation of 5-HT as a 'false transmitter' in striatal dopamine (DA) neurons. Fast cyclic voltammetry at carbon fibre microelectrodes (CFMs) was used to monitor striatal monoamine release following electrical stimulation of the median forebrain bundle (MFB). In the absence of any pretreatment DA was the sole compound released by stimulation. However, when DA release was abolished with alpha-methyl-p-tyrosine (AMPT), 5-HTP administration (after peripheral decarboxylase inhibition) caused a dose-dependent release of 5-HT, confirmed by the voltammetric characteristics. Central decarboxylase inhibition prevented release indicating that 5-HTP itself was not released. By monitoring reduction peaks it was possible to record DA and 5-HT release simultaneously at a single CFM. While DA and 5-HT oxidised at the same potential their reduction peaks were separated by approximately 450 mV. It was shown, using this means, that 5-HT was still detectable even when DA release was not abolished by AMPT. DA and 5-HT release showed a significant positive correlation suggesting that they were released from the same nerves. We conclude that, after 5-HTP treatment, 5-HT can be released as a false transmitter from striatal DA neurones.
Longo, G; Rudoi, I; Iannuccelli, M; Strinati, R; Panizon, F
1984-01-01
Thirty patients (mean age: 10.38 years) affected by primary headache were selected for a double-blind cross-over clinical trial. The patients were randomized into 2 homogeneous groups of 15 and treated for 12 weeks with L-5-HTP (100 mg/day) and placebo as per the following design: placebo - L-5-HTP (group A) and L-5-HTP - placebo (group B). Evaluation was carried out every 3 weeks by the Migraine Index supplying a general assessment of the attacks, i.e. severity, duration and frequency. The decrease in mean score values was directly proportional to L-5-HTP treatment, and statistical significance (Wilcoxon's test) was observed only for L-5-HTP in both groups, from 0.05 to 0.01. Improvement, as evaluated by CGI on percentage distribution of the patients, was homogeneous in both groups.
Considerations for Storage of High Test Hydrogen Peroxide (HTP) Utilizing Non-Metal Containers
Moore, Robin E.; Scott, Joseph P.; Wise, Harry
2005-01-01
When working with high concentrations of hydrogen peroxide, it is critical that the storage container be constructed of the proper materials, those which will not degrade to the extent that container breakdown or dangerous decomposition occurs. It has been suggested that the only materials that will safely contain the peroxide for a significant period of time are metals of stainless steel construction or aluminum use as High Test Hydrogen Peroxide (HTP) Containers. The stability and decomposition of HTP will be also discussed as well as various means suggested in the literature to minimize these problems. The dangers of excess oxygen generation are also touched upon.
Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin
Kazuhiro Nakamura; Hiroyuki Hasegawa
2009-01-01
Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the synthesis of 5-hydroxy-L-tryptophan (5-HTP) from L-tryptophan. This step is dictated by an enzyme, tryptophan hydroxylase (TPH). TPH requires 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as a co-substrate of TPH. 5-HTP has been simply regarded as a precursor...
Energy Technology Data Exchange (ETDEWEB)
Shindler, A. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC
2007-07-15
I review the theoretical foundations, properties as well as the simulation results obtained so far of a variant of the Wilson lattice QCD formulation: Wilson twisted mass lattice QCD. Emphasis is put on the discretization errors and on the effects of these discretization errors on the phase structure for Wilson-like fermions in the chiral limit. The possibility to use in lattice simulations different lattice actions for sea and valence quarks to ease the renormalization patterns of phenomenologically relevant local operators, is also discussed. (orig.)
Twisting formula of epsilon factors
Indian Academy of Sciences (India)
SAZZAD ALI BISWAS
2017-09-01
For characters of a non-Archimedean local field we have explicit formula for epsilon factors. But in general, we do not have any generalized twisting formula of epsilon factors. In this paper, we give a generalized twisting formula of epsilon factorsvia local Jacobi sums.
Valve-aided twisted Savonius rotor
Energy Technology Data Exchange (ETDEWEB)
Jaya Rajkumar, M.; Saha, U.K.
2006-05-15
Accessories, such as end plates, deflecting plates, shielding and guide vanes, may increase the power of a Savonius rotor, but make the system structurally complex. In such cases, the rotor can develop a relatively large torque at small rotational speeds and is cheap to build, however it harnesses only a small fraction of the incident wind energy. Another proposition for increasing specific output is to place non-return valves inside the concave side of the blades. Such methods have been studied experimentally with a twisted-blade Thus improving a Savonius rotor's energy capture. This new concept has been named as the 'Valve-Aided Twisted Savonius'rotor. Tests were conducted in a low-speed wind tunnel to evaluate performance. This mechanism is found to be independent of flow direction, and shows potential for large machines. [Author].
Twisted supergravity and its quantization
Costello, Kevin
2016-01-01
Twisted supergravity is supergravity in a background where the bosonic ghost field takes a non-zero value. This is the supergravity counterpart of the familiar concept of twisting supersymmetric field theories. In this paper, we give conjectural descriptions of type IIA and IIB supergravity in $10$ dimensions. Our conjectural descriptions are in terms of the closed-string field theories associated to certain topological string theories, and we conjecture that these topological string theories are twists of the physical string theories. For type IIB, the results of arXiv:1505.6703 show that our candidate twisted supergravity theory admits a unique quantization in perturbation theory. This is despite the fact that the theories, like the original physical theories, are non-renormalizable. Although we do not prove our conjectures, we amass considerable evidence. We find that our candidates for the twisted supergravity theories contain the residual supersymmetry one would expect. We also prove (using heavily a res...
Loss of Loved Ones and the Drawing of Dead or Broken Branches on the HTP
Bluestein, Venus
1978-01-01
The HTP technique is commonly used in the assessment of children and adults. Children who have lost a loved one through death frequently label a portion of the Tree as dead. This phenomenon appears unrelated to age, sex, socioeconomic status, or race. (Author)
HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans.
Couteau, Florence; Zetka, Monique
2005-11-15
During meiosis, the mechanisms responsible for homolog alignment, synapsis, and recombination are precisely coordinated to culminate in the formation of crossovers capable of directing accurate chromosome segregation. An outstanding question is how the cell ensures that the structural hallmark of meiosis, the synaptonemal complex (SC), forms only between aligned pairs of homologous chromosomes. In the present study, we find that two closely related members of the him-3 gene family in Caenorhabditis elegans function as regulators of synapsis. HTP-1 functionally couples homolog alignment to its stabilization by synapsis by preventing the association of SC components with unaligned and immature chromosome axes; in the absence of the protein, nonhomologous contacts between chromosomes are inappropriately stabilized, resulting in extensive nonhomologous synapsis and a drastic decline in chiasma formation. In the absence of both HTP-1 and HTP-2, synapsis is abrogated per se and the early association of SC components with chromosomes observed in htp-1 mutants does not occur, suggesting a function for the proteins in licensing SC assembly. Furthermore, our results suggest that early steps of recombination occur in a narrow window of opportunity in early prophase that ends with SC assembly, resulting in a mechanistic coupling of the two processes to promote crossing over.
Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors.
Gartside, S E; Cowen, P J
1990-04-10
Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prolactin and ACTH responses to 5-HTP (100 mg/kg) were attenuated by pretreatment with the non-selective 5-HT receptor antagonist, metergoline (0.5 mg/kg), and by the selective 5-HT2 receptor antagonists, ritanserin (0.4 mg/kg), ketanserin (2.5 mg/kg), ICI (5.0 mg/kg) and spiperone (1.0 mg/kg). The 5-HT1 receptor antagonists, propranolol (40 mg/kg) and pindolol (4.0 mg/kg), failed to antagonize the prolactin and ACTH responses to 5-HTP (100 mg/kg), as did the selective 5-HT3 receptor antagonist, BRL 43694 (1.0 mg/kg). The results suggest that the prolactin and ACTH responses to 5-HTP in the male rat are mediated by 5-HT2 receptors.
Serum beta-2-microglobulin (beta-2-M) levels in heart transplant patients (HTP).
Grzeszczak, W; Zukowska-Szczechowska, E; Zembala, M; Religa, Z; Pokrzywnicki, W; Kochanska-Dziurowicz, A
1996-12-01
The present paper aim to answer following questions: 1. What is serum beta-2-M levels in HTP? 2. Does significant correlations between serum beta-2-M levels and serum creatinine levels or creatinine clearance (inulin clearance) exit? 3. Does any significant correlation between serum beta-2-M levels and blood cyclosporine A concentration exit? Three groups of subjects were studied. The first group consisted of 33 heart transplant patients (HTP), the second group consisted of 12 patients with small decline kidney function, and the third one consisted of 36 healthy subjects. In all examined subjects serum beta-2-M (RIA) creatinine, creatinine and inulin (steady state dosis method) clearance were assessed. 1. In observed HTP serum beta-2-M level is significantly higher then in controls and patients with small decline kidney function; 2. A significant correlation between kidney function and -2-M level in HTP as well as in other examined groups subjects exit; 3. Presence a significant positive correlation between serum beta-2-M level and blood cyclosporine A concentration suggest that beta-2-M level can be a good parametr to define cyclosporine A tubular toxicity.
The 5-HTP sip tryp: a timely word to the wise
Directory of Open Access Journals (Sweden)
Basu P
2013-05-01
Full Text Available Priyoneel Basu, Muniyandi SingaravelChronobiology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, IndiaRecently, an editorial in Nature Neuroscience pointed out the need for exercising caution in the use of over-the-counter drinks purporting to promote relaxation and containing, among other substances with chronobiotic activity, L-5-Hydroxytryptophan (5-HTP.1 This reality-check certainly raises an issue worth the attention of scientists who deal with, and laymen who dabble in, biological rhythms. Proprietary and patented formulations often project an image of safety, which is augmented by their over-the-counter availability as attractively packaged nutritional supplements. The allure of these bottled shots of bliss may seem undeniable to the general public. An online search of the words "5-HTP relaxation drink" returns > 7 million websites. Websites promoting these drinks do carry limited warnings or disclaimers (in fine print. The actual concentration of constituents is sometimes not provided in the online information leaflets. Certain websites provide a Natural Standard Editorial Board blinded review,2,3 which summarizes known scientific literature (exhaustively and mentions likely safe doses. In view of the rising popularity and wide availability of 5-HTP containing drinks, we feel that scientists and the general public alike would profit from an additional nugget of information regarding a previously unforeseen effect of 5-HTP consumption at an inappropriate time, as brought to light by recent literature in the area.View orignal paper by Narsimhan
Twisted bialgebroids versus bialgebroids from a Drinfeld twist
Borowiec, Andrzej; Pachoł, Anna
2017-02-01
Bialgebroids (respectively Hopf algebroids) are bialgebras (Hopf algebras) over noncommutative rings. Drinfeld twist techniques are particularly useful in the (deformation) quantization of Lie algebras as well as the underlying module algebras (=quantum spaces). A smash product construction combines both of them into the new algebra which, in fact, does not depend on the twist. However, we can turn it into a bialgebroid in a twist-dependent way. Alternatively, one can use Drinfeld twist techniques in a category of bialgebroids. We show that both the techniques indicated in the title—the twisting of a bialgebroid or constructing a bialgebroid from the twisted bialgebra—give rise to the same result in the case of a normalized cocycle twist. This can be useful for the better description of a quantum deformed phase space. We argue that within this bialgebroid framework one can justify the use of deformed coordinates (i.e. spacetime noncommutativity), which are frequently postulated in order to explain quantum gravity effects.
Preliminary fMRI findings concerning the influence of 5-HTP on food selection.
Ioannou, Stephanos; Williams, Adrian L
2017-01-01
This functional magnetic resonance imaging study was designed to observe how physiological brain states can alter food preferences. A primary goal was to observe food-sensitive regions and moreover examine whether 5-HTP intake would activate areas which have been associated with appetite suppression, anorexia, satiety, and weight loss. Fourteen healthy male and female participants took part in the study, of which half of them received the supplement 5-HTP and the rest vitamin C (control) on an empty stomach. During the scanning session, they passively observed food (high calories, proteins, carbohydrates) and nonfood movie stimuli. Within the 5-HTP group, a comparison of food and nonfood stimuli showed significant responses that included the limbic system, the basal ganglia, and the prefrontal, temporal, and parietal cortices. For the vitamin C group, activity was mainly located in temporal and occipital regions. Compared to the vitamin C group, the 5-HTP group in response to food showed increased activation on the VMPFC, the DLPFC, limbic, and temporal regions. For the 5-HTP group, activity in response to food high in protein content compared to food high in calories and carbohydrates was located in the limbic system and the right caudomedial OFC, whereas for the vitamin C group, activity was mainly located at the inferior parietal lobes, the anterior cingulate gyri, and the left ventrolateral OFC. Greater responses to carbohydrates and high calorie stimuli in the vitamin C group were located at the right temporal gyrus, the occipital gyrus, the right VLPFC, whereas for the 5-HTP group, activity was observed at the left VMPFC, the parahippocampal gyrus bilaterally, the occipital lobe, and middle temporal gyri. In line with the hypotheses, 5-HTP triggered cortical responses associated with healthy body weight as well as cerebral preferences for protein-rich stimuli. The brain's activity is altered by macronutrients rich or deprived in the body. By reading the
[11C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain
Visser, Anniek KD; Ramakrishnan, Nisha K; Willemsen, Antoon TM; Di Gialleonardo, Valentina; de Vries, Erik FJ; Kema, Ido P; Dierckx, Rudi AJO; van Waarde, Aren
2014-01-01
The PET tracer [11C]5-hydroxytryptophan ([11C]5-HTP), which is converted to [11C]5-hydroxytryptamine ([11C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to measure 5-HT synthesis rates. But can we measure these synthesis rates by kinetic modeling of [11C]5-HTP in rat? Male rats were scanned with [11C]5-HTP (60 minutes) after different treatments. Scans included arterial blood sampling and metabolite analysis. 5-HT synthesis rates were calculated by a two-tissue compartment model (2TCM) with irreversible tracer trapping or Patlak analysis. Carbidopa (inhibitor peripheral AADC) dose-dependently increased [11C]5-HTP brain uptake, but did not influence 2TCM parameters. Therefore, 10 mg/kg carbidopa was applied in all subsequent study groups. These groups included treatment with NSD 1015 (general AADC inhibitor) or p-chlorophenylalanine (PCPA, inhibitor of tryptophan hydroxylase, TPH). In addition, the effect of a low-tryptophan (Trp) diet was investigated. NSD 1015 or Trp depletion did not affect any model parameters, but PCPA reduced [11C]5-HTP uptake, and the k3. This was unexpected as NSD 1015 directly inhibits the enzyme converting [11C]5-HTP to [11C]5-HT, suggesting that trapping of radioactivity does not distinguish between parent tracer and its metabolites. As different results have been acquired in monkeys and humans, [11C]5-HTP-PET may be suitable for measuring 5-HT synthesis in primates, but not in rodents. PMID:24084697
Hong, Ki-Bae; Park, Yooheon; Suh, Hyung Joo
2016-04-01
This study was to investigate the sleep promoting effects of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), by examining neuronal processes governing mRNA level alterations, as well as assessing neuromodulator concentrations, in a fruit fly model. Behavioral assays were applied to investigate subjective nighttime activity, sleep episodes, and total duration of subjective nighttime sleep of two amino acids and GABA/5-HTP mixture with caffeine treated flies. Also, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. Subjective nighttime activity and sleep patterns of individual flies significantly decreased with 1% GABA treatment in conjunction with 0.1% 5-HTP treatment (pHTP mixture resulted in significant differences between groups related to sleep patterns (40%, pHTP mixture significantly increased GABA levels 1h and 12h following treatment (2.1 fold and 1.2 fold higher than the control, respectively) and also increased 5-HTP levels (0 h: 1.01 μg/protein, 12h: 3.45 μg/protein). In this regard, we successfully demonstrated that using a GABA/5-HTP mixture modulates subjective nighttime activity, sleep episodes, and total duration of subjective nighttime sleep to a greater extent than single administration of each amino acid, and that this modulation occurs via GABAergic and serotonergic signaling. Copyright © 2016 Elsevier Inc. All rights reserved.
[(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain.
Visser, Anniek K D; Ramakrishnan, Nisha K; Willemsen, Antoon T M; Di Gialleonardo, Valentina; de Vries, Erik F J; Kema, Ido P; Dierckx, Rudi A J O; van Waarde, Aren
2014-01-01
The PET tracer [(11)C]5-hydroxytryptophan ([(11)C]5-HTP), which is converted to [(11)C]5-hydroxytryptamine ([(11)C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to measure 5-HT synthesis rates. But can we measure these synthesis rates by kinetic modeling of [(11)C]5-HTP in rat? Male rats were scanned with [(11)C]5-HTP (60 minutes) after different treatments. Scans included arterial blood sampling and metabolite analysis. 5-HT synthesis rates were calculated by a two-tissue compartment model (2TCM) with irreversible tracer trapping or Patlak analysis. Carbidopa (inhibitor peripheral AADC) dose-dependently increased [(11)C]5-HTP brain uptake, but did not influence 2TCM parameters. Therefore, 10 mg/kg carbidopa was applied in all subsequent study groups. These groups included treatment with NSD 1015 (general AADC inhibitor) or p-chlorophenylalanine (PCPA, inhibitor of tryptophan hydroxylase, TPH). In addition, the effect of a low-tryptophan (Trp) diet was investigated. NSD 1015 or Trp depletion did not affect any model parameters, but PCPA reduced [(11)C]5-HTP uptake, and the k3. This was unexpected as NSD 1015 directly inhibits the enzyme converting [(11)C]5-HTP to [(11)C]5-HT, suggesting that trapping of radioactivity does not distinguish between parent tracer and its metabolites. As different results have been acquired in monkeys and humans, [(11)C]5-HTP-PET may be suitable for measuring 5-HT synthesis in primates, but not in rodents.
Performance of twist-coupled blades on variable speed rotors
Energy Technology Data Exchange (ETDEWEB)
Lobitz, D.W.; Veers, P.S.; Laino, D.J.
1999-12-07
The load mitigation and energy capture characteristics of twist-coupled HAWT blades that are mounted on a variable speed rotor are investigated in this paper. These blades are designed to twist toward feather as they bend with pretwist set to achieve a desirable twist distribution at rated power. For this investigation, the ADAMS-WT software has been modified to include blade models with bending-twist coupling. Using twist-coupled and uncoupled models, the ADAMS software is exercised for steady wind environments to generate C{sub p} curves at a number of operating speeds to compare the efficiencies of the two models. The ADAMS software is also used to generate the response of a twist-coupled variable speed rotor to a spectrum of stochastic wind time series. This spectrum contains time series with two mean wind speeds at two turbulence levels. Power control is achieved by imposing a reactive torque on the low speed shaft proportional to the RPM squared with the coefficient specified so that the rotor operates at peak efficiency in the linear aerodynamic range, and by limiting the maximum RPM to take advantage of the stall controlled nature of the rotor. Fatigue calculations are done for the generated load histories using a range of material exponents that represent materials from welded steel to aluminum to composites, and results are compared with the damage computed for the rotor without twist-coupling. Results indicate that significant reductions in damage are achieved across the spectrum of applied wind loading without any degradation in power production.
Semantic Deviation in Oliver Twist
Institute of Scientific and Technical Information of China (English)
康艺凡
2016-01-01
Dickens, with his adeptness with language, applies semantic deviation skillfully in his realistic novel Oliver Twist. However, most studies and comments home and abroad on it mainly focus on such aspects as humanity, society, and characters. Therefore, this thesis will take a stylistic approach to Oliver Twist from the perspective of semantic deviation, which is achieved by the use of irony, hyperbole, and pun and analyze how the application of the technique makes the novel attractive.
National Research Council Canada - National Science Library
Camilo, Cesar M; Lima, Gustavo M.A; Maluf, Fernando V; Guido, Rafael V.C; Polikarpov, Igor
2016-01-01
.... HTP-OligoDesigner was created to provide the scientific community with a simple and intuitive online primer design tool for both laboratory-scale and high-throughput projects of sequence-independent...
Trouillas, P; Garde, A; Robert, J M; Renaud, B; Adeleine, P; Bard, J; Brudon, F
1982-01-01
A quantitative evaluation of cerebellar ataxia, with an ataxia score (total, static, kinetic) and the measurement of objective values related to the major symptoms, is proposed. 21 patients with heredo-ataxias were treated for 12 months with high doses (16 mg/kg/day) of D-L-5-HTP, L-5-HTP or the association D-L-5-HTP (16 mg/kg/day)-Benserazide(6 mg/kg/day). A computerized processing of the data obtained by regular examination was performed. The ataxia showed a significant regression at the 12th month, mainly in the static performances and in the speed of speech. L-5-HTP appeared to be more active than D-L-5-HTP. The regression of the cerebellar ataxia was also observed in non degenerative conditions such as multiple sclerosis and surgical injury of the anterior lobe vermis, showing that 5-HTP was active on the cerebellar syndrome in general. The regression of the cerebellar ataxia was very slow in inherited diseases and continued for 2 or 4 months after the treatment stopped. A serotoninergic cerebellar control of motricity is discussed.
Speziale, Simone
2013-01-01
We define and investigate a quantisation of null hypersurfaces in the context of loop quantum gravity on a fixed graph. The main tool we use is the parametrisation of the theory in terms of twistors, which has already proved useful in discussing the interpretation of spin networks as the quantization of twisted geometries. The classical formalism can be extended in a natural way to null hypersurfaces, with the Euclidean polyhedra replaced by null polyhedra with space-like faces, and SU(2) by the little group ISO(2). The main difference is that the simplicity constraints present in the formalims are all first class, and the symplectic reduction selects only the helicity subgroup of the little group. As a consequence, information on the shapes of the polyhedra is lost, and the result is a much simpler, abelian geometric picture. It can be described by an Euclidean singular structure on the 2-dimensional space-like surface defined by a foliation of space-time by null hypersurfaces. This geometric structure is na...
"Twisted Beam" SEE Observations of Ionospheric Heating from HAARP
Briczinski, S. J.; Bernhardt, P. A.; Siefring, C. L.; Han, S.-M.; Pedersen, T. R.; Scales, W. A.
2015-10-01
Nonlinear interactions of high power HF radio waves in the ionosphere provide aeronomers with a unique space-based laboratory capability. The High-Frequency Active Auroral Research Program (HAARP) in Gakona, Alaska is the world's largest heating facility, yielding effective radiated powers in the gigawatt range. New results are present from HAARP experiments using a "twisted beam" excitation mode. Analysis of twisted beam heating shows that the SEE results obtained are identical to more traditional patterns. One difference in the twisted beam mode is the heating region produced is in the shape of a ring as opposed to the more traditional "solid spot" region from a pencil beam. The ring heating pattern may be more conducive to the creation of stable artificial airglow layers because of the horizontal structure of the ring. The results of these runs include artificial layer creation and evolution as pertaining to the twisted beam pattern. The SEE measurements aid the interpretation of the twisted beam interactions in the ionosphere.
HTP kinetics studies on isolated elementary combustion reactions over wide temperature ranges
Energy Technology Data Exchange (ETDEWEB)
Fontijn, A.; Adusei, G.Y.; Hranisavlevic, J.; Bajaj, P.N. [Rensselaer Polytechnic Institute, Troy, NY (United States)
1993-12-01
The goals of this project are to provide accurate data on the temperature dependence of the kinetics of elementary combustion reactions, (i) for use by combustion modelers, and (ii) to gain a better fundamental understanding of, and hence predictive ability for, the chemistry involved. Experimental measurements are made mainly by using the pseudo-static HTP (high-temperature photochemistry) technique. While continuing rate coefficient measurements, further aspects of kinetics research are being explored. Thus, starting from the data obtained, a method for predicting the temperature dependence of rate coefficients of oxygen-atom olefin experiment and confirms the underlying mechanistic assumptions. Mechanistic information of another sort, i.e. by product analysis, has recently become accessible with the inauguration of our heated flow tube mass spectrometer facility; early results are reported here. HTP experiments designed to lead to measurements of product channels by resonance fluorescence have started.
R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram
DEFF Research Database (Denmark)
Sánchez, Connie; Kreilgaard, Mads
2004-01-01
Escitalopram mediates the serotonin re-uptake inhibitory and antidepressant effect of citalopram racemate. However, recent studies have shown that R-citalopram inhibits the escitalopram-induced increase of extracellular 5-HT levels in the frontal cortex of rats. Here, we investigated the inhibitory...... effect of R-citalopram on the escitalopram-induced increase of 5-HT neurotransmission at the behavioural [potentiation of 5-hydroxytryptophan (5-HTP)-induced behavioural changes in mice and rats] and functional (increase in serum corticosterone in rats) levels. The effect of escitalopram was inhibited...... by R-citalopram in all three models, and R-citalopram, given alone, was inactive. The effects were more pronounced using an escitalopram to R-citalopram ratio of 1:4 than ratios of 1:2 and 1:1, suggesting a dose-dependent effect. The ED(50)-value of escitalopram in mouse 5-HTP potentiation studies...
Microstructure Development during Roughing and Intermediate Cooling of Thick HTP Linepipe Steels
Banks, Kevin; Maubane, Rorisang
The microstructural development during roughing and early finishing of thick, high Nb-Ti steels containing high and low Mn contents has been investigated for conventional cold charging (CCR) and quasi compact strip production (CSP) conditions. Multi-pass rolling simulations were performed, followed by interrupted accelerated cooling, to study the "as-coiled" ferrite/pearlite microstructure. Local heterogeneous regions, LHR, were often found after CSP simulations, but not after CCR where the microstructure was generally uniform. Coarse, local heterogeneous regions can be prevented in HTP steels though complete recrystallization of the as-cast austenite during and after roughing by i) applying sufficient strain at roughing temperatures above the TiNb(C,N) precipitation region, ii) slow intermediate cooling and iii) using high Mn contents to suppress precipitation. For thick HTP skelp, the initiation of dynamic recrystallization is of little use in avoiding LHR due to limited strain available for completing the necklacing process.
Surface Characterization of LMMS Molybdenum Disilicide Coated HTP-8 Using Arc- Jet Hypersonic Flow
Stewart, David A.
2000-01-01
Surface properties for an advanced Lockheed Martin Missile and Space (LMMS) molybdenum disilicide coated insulation (HTP-8) were determined using arc-jet flow to simulate Earth entry at hypersonic speeds. The catalytic efficiency (atom recombination coefficients) for this advanced thermal protection system was determined from arc-jet data taken in both oxygen and nitrogen streams at temperatures ranging from 1255 K to roughly 1600 K. In addition, optical and chemical stability data were obtained from these test samples.
T-maze performance after developmental exposure to 19F tagged 5-HTP in chicks.
Dingman, Sherry; Nash, Laurie; Hogan, Jeremy; Branch, Craig
2004-12-01
Chicks were used as a model to investigate behavioral effects of administering a new compound intended for use with magnetic resonance. The compound has multiple 19F atom tags covalently bonded to the indole ring of 5-hydroxytryptophan (PF-5HTP), the immediate precursor to the neurotransmitter serotonin. On incubation Day 17, 5 microg of PF-5-HTP, an equivalent amount of 5-HTP, or just 200 microL of the weak phosphate buffered saline (PBS) vehicle was injected into the airsac of each egg. Three days after hatching, chicks were isolated at the top of a simple T-Maze which, when traversed correctly, enabled them to return to their brood mates. A second trial in the T-Maze was conducted about three hours later. The brief period of isolation at the start of a trial causes social distress in chicks who are reinforced by returning to the brood. The task was selected as being sensitive to functioning of the serotonin pathways whose development might be altered by administering the compound during brain development. Repeated-measures analysis of variance yielded a statistically significant main effect for trial within groups, but no significant difference between injection groups. Administering a low dose of the fluorine tagged compound during development did not impair performance on this T-maze task.
5-HTP induced diarrhea as a carcinoid syndrome model in mice?
Bourin, M; Hascoet, M; Deguiral, P
1996-01-01
Serotonin (5-HT) is present in the gastrointestinal tract and is probably one of the compounds responsible for diarrhea in patients presenting with carcinoid syndrome. Intraperitoneal administration of L-5-hydroxytryptophan (L-5-HTP) at doses of 25 to 100 mg/kg dramatically increase defecation in mice. In this new paradigm, counting fecal boli deposited is simple and the appraised or inhibition of diarrhea induced by ip 25 mg/kg of L-5-HIP is very clear, with a good reproducibility of scores. L-5-HTP needs to be metabolized into 5-HT to be active; benserazide, an inhibitor of decarboxylase, antagonized the diarrhea induced by 5-HT. Among the 5-HT antagonists used in interaction with 5-HT, only these of the 5-HT3 type (ondansetron, granisetron, tropisetron) and, to a lesser extent 5-HT2 type (ritanserin), decreased the diarrhea induced by 5-HTP. The 5-HT4 receptor agonists from the benzamide family (metoclopramide and zacopride) increased defecation in mice but the effect failed to reach statistical significance.
Extension-twist coupling optimization in composite rotor blades
Ozbay, Serkan
2005-07-01
For optimal rotor performance in a tiltrotor aircraft the difference in the inflow and the rotor speeds between the hover and cruise flight modes suggests different blade twist and chord distributions. The blade twist rates in current tiltrotor applications are defined based upon a compromise between the figure of merit in hover and propeller efficiency in airplane mode. However, when each operation mode is considered separately the optimum blade distributions are found to be considerably different. Passive blade twist control, which uses the inherent variation in centrifugal forces on a rotor blade to achieve optimum blade twist distributions in each flight mode through the use of extension-twist coupled composite rotor blades, has been considered for performance improvement of tiltrotor aircraft over the last two decades. The challenge for this concept is to achieve the desired twisting deformations in the rotor blade without altering the aeroelastic characteristics of the vehicle. A concept referred to as the sliding mass concept is proposed in this work in order to increase the twist change with rotor speed for a closed-cell composite rotor blade cross-section to practical levels for performance improvement in a tiltrotor aircraft. The concept is based on load path changes for the centrifugal forces by utilizing non-structural masses readily available on a conventional blade, such as the leading edge balancing mass. A multilevel optimization technique based on the simulated annealing method is applied to improve the performance of the XV15 tiltrotor aircraft. A cross-sectional analysis tool, VABS together with a multibody dynamics code, DYMORE are integrated into the optimization process. The optimization results revealed significant improvements in the power requirement in hover while preserving cruise efficiency. It is also shown that about 21% of the improvement is provided through the sliding mass concept pointing to the additional flexibility the concept
Higher twist effects in deeply virtual Compton scattering
Energy Technology Data Exchange (ETDEWEB)
Pirnay, Bjoern Michael
2016-08-01
In this work we explore the effects of higher twist power corrections on the deeply virtual Compton scattering process. The calculation of the helicity amplitudes for all possible polarization combinations is performed within the framework of QCD operator product expansion. As a result the known accuracy of the amplitudes is improved to include the (kinematic) twist-4 contributions. For the most part the analysis focuses on spin-1/2 targets, the answers for scalar targets conveniently emerge as a byproduct. We investigate the analytical structure of these corrections and prove consistency with QCD factorization. We give an estimation of the numerical impact of the sub-leading twist contributions for proton targets with the help of a phenomenological model for the nonperturbative proton generalized parton distributions. We compare different twist approximations and relate predictions for physical observables to experiments performed by the Hall A, CLAS, HERMES, H1 and ZEUS collaborations. The estimate also includes a numerical study for planned COMPASS-II runs. Throughout the analysis special emphasis is put on the convention dependence induced by finite twist truncation of scattering amplitudes.
Interfacial Atomic Structure of Twisted Few-Layer Graphene.
Ishikawa, Ryo; Lugg, Nathan R; Inoue, Kazutoshi; Sawada, Hidetaka; Taniguchi, Takashi; Shibata, Naoya; Ikuhara, Yuichi
2016-02-18
A twist in bi- or few-layer graphene breaks the local symmetry, introducing a number of intriguing physical properties such as opening new bandgaps. Therefore, determining the twisted atomic structure is critical to understanding and controlling the functional properties of graphene. Combining low-angle annular dark-field electron microscopy with image simulations, we directly determine the atomic structure of twisted few-layer graphene in terms of a moiré superstructure which is parameterized by a single twist angle and lattice constant. This method is shown to be a powerful tool for accurately determining the atomic structure of two-dimensional materials such as graphene, even in the presence of experimental errors. Using coincidence-site-lattice and displacement-shift-complete theories, we show that the in-plane translation state between layers is not a significant structure parameter, explaining why the present method is adequate not only for bilayer graphene but also a few-layered twisted graphene.
Curvature regulation of the ciliary beat through axonemal twist
Sartori, Pablo; Geyer, Veikko F.; Howard, Jonathon; Jülicher, Frank
2016-10-01
Cilia and flagella are hairlike organelles that propel cells through fluid. The active motion of the axoneme, the motile structure inside cilia and flagella, is powered by molecular motors of the axonemal dynein family. These motors generate forces and torques that slide and bend the microtubule doublets within the axoneme. To create regular waveforms, the activities of the dyneins must be coordinated. It is thought that coordination is mediated by stresses due to radial, transverse, or sliding deformations, and which build up within the moving axoneme and feed back on dynein activity. However, which particular components of the stress regulate the motors to produce the observed waveforms of the many different types of flagella remains an open question. To address this question, we describe the axoneme as a three-dimensional bundle of filaments and characterize its mechanics. We show that regulation of the motors by radial and transverse stresses can lead to a coordinated flagellar motion only in the presence of twist. We show that twist, which could arise from torque produced by the dyneins, couples curvature to transverse and radial stresses. We calculate emergent beating patterns in twisted axonemes resulting from regulation by transverse stresses. The resulting waveforms are similar to those observed in flagella of Chlamydomonas and sperm. Due to the twist, the waveform has nonplanar components, which result in swimming trajectories such as twisted ribbons and helices, which agree with observations.
The epsilon regime with twisted mass Wilson fermions
Bar, Oliver; Shindler, Andrea
2010-01-01
We investigate the leading lattice spacing effects in mesonic two-point correlators computed with twisted mass Wilson fermions in the epsilon-regime. By generalizing the procedure already introduced for the untwisted Wilson chiral effective theory, we extend the continuum chiral epsilon expansion to twisted mass WChPT. We define different regimes, depending on the relative power counting for the quark masses and the lattice spacing. We explicitly compute, for arbitrary twist angle, the leading O(a^2) corrections appearing at NLO in the so-called GSM^* regime. As in untwisted WChPT, we find that in this situation the impact of explicit chiral symmetry breaking due to lattice artefacts is strongly suppressed. Of particular interest is the case of maximal twist, which corresponds to the setup usually adopted in lattice simulations with twisted mass Wilson fermions. The formulae we obtain can be matched to lattice data to extract physical low energy couplings, and to estimate systematic uncertainties coming from ...
Comments on twisted indices in 3d supersymmetric gauge theories
Energy Technology Data Exchange (ETDEWEB)
Closset, Cyril [Simons Center for Geometry and PhysicsState University of New York, Stony Brook, NY 11794 (United States); Kim, Heeyeon [Perimeter Institute for Theoretical Physics31 Caroline Street North, Waterloo, N2L 2Y5, Ontario (Canada)
2016-08-09
We study three-dimensional N=2 supersymmetric gauge theories on Σ{sub g}×S{sup 1} with a topological twist along Σ{sub g}, a genus-g Riemann surface. The twisted supersymmetric index at genus g and the correlation functions of half-BPS loop operators on S{sup 1} can be computed exactly by supersymmetric localization. For g=1, this gives a simple UV computation of the 3d Witten index. Twisted indices provide us with a clean derivation of the quantum algebra of supersymmetric Wilson loops, for any Yang-Mills-Chern-Simons-matter theory, in terms of the associated Bethe equations for the theory on ℝ{sup 2}×S{sup 1}. This also provides a powerful and simple tool to study 3d N=2 Seiberg dualities. Finally, we study A- and B-twisted indices for N=4 supersymmetric gauge theories, which turns out to be very useful for quantitative studies of three-dimensional mirror symmetry. We also briefly comment on a relation between the S{sup 2}×S{sup 1} twisted indices and the Hilbert series of N=4 moduli spaces.
Interfacial Atomic Structure of Twisted Few-Layer Graphene
Ishikawa, Ryo; Lugg, Nathan R.; Inoue, Kazutoshi; Sawada, Hidetaka; Taniguchi, Takashi; Shibata, Naoya; Ikuhara, Yuichi
2016-02-01
A twist in bi- or few-layer graphene breaks the local symmetry, introducing a number of intriguing physical properties such as opening new bandgaps. Therefore, determining the twisted atomic structure is critical to understanding and controlling the functional properties of graphene. Combining low-angle annular dark-field electron microscopy with image simulations, we directly determine the atomic structure of twisted few-layer graphene in terms of a moiré superstructure which is parameterized by a single twist angle and lattice constant. This method is shown to be a powerful tool for accurately determining the atomic structure of two-dimensional materials such as graphene, even in the presence of experimental errors. Using coincidence-site-lattice and displacement-shift-complete theories, we show that the in-plane translation state between layers is not a significant structure parameter, explaining why the present method is adequate not only for bilayer graphene but also a few-layered twisted graphene.
Polarization twist in perovskite ferrielectrics.
Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro
2016-09-02
Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of 'polarization twist', which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms.
Touret, M; Sarda, N; Gharib, A; Geffard, M; Jouvet, M
1991-01-01
In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-acid-decarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.
Meltzer, H Y; Maes, M
1994-05-01
Previous studies with direct-acting serotonin (5-HT) agonists and antagonists have demonstrated that stimulation of 5-HT1A, 5-HT1C and 5-HT2 receptors may promote cortisol and prolactin (PRL) secretion in man. There is also evidence that 5-HT1C/2 receptor stimulation contributes to the cortisol and PRL responses following administration of the 5-HT precursor, L-5-hydroxytryptophan (L-5-HTP), in man. To clarify the possible contribution of 5-HT1A receptor stimulation to the ability of L-5-HTP to stimulate cortisol and PRL secretion in man, the effect of pindolol, a beta adrenoceptor antagonist that is also a 5-HT1A partial agonist, on the L-5-HTP-induced increases in cortisol and PRL secretion, was examined in 12 normal male volunteers. Pretreatment with pindolol, 30 mg orally, significantly inhibited the PRL but not the cortisol response to L-5-HTP, 200 mg PO. Pindolol alone decreased basal plasma PRL levels and increased basal plasma cortisol levels, possibly due to 5-HT1A antagonist and agonists effects, respectively. These data, coupled with observations from other studies, suggest that the L-5-HTP-induced increase in PRL but not cortisol secretion requires 5-HT1A receptor activation. PRL secretion due to 5-HT formed from exogenous L-5-HTP may require the availability of both intact 5-HT1A and 5-HT2/5-HT1C receptors, since blockade of either receptor type inhibited the PRL response to L-5-HTP. The implication of this synergistic effect for interpretation of neuroendocrine studies involving the serotonergic system in man is discussed.
Atrium and HTP fuel elements for the U. S. market. Atrium- und HTP-Brennelemente fuer den US-Markt
Energy Technology Data Exchange (ETDEWEB)
Morgan, J.N. (Siemens Power Corp. Nuclear Div., Engineering and Manufacturing Facility, Richland, WA (United States)); Krebs, W.D. (Technik Brennelemente und Reaktorkern, Siemens AG Bereich Energieerzeugung (KWU), Erlangen (Germany))
1994-07-01
The international acitivities of Siemens in the nuclear fuel sector are the responsibility of the Nuclear Fuel Cycle Unit of the Power Generation Division (KWU) in Germany, the Nuclear Dividion of Siemens Power Corporation (SPC) in the Unites States, and the German Siemens subsidiaries, ANF GmbH (fuel element fabrication) in Lingen and NRG - Nuklearrohr Gesellschaft mbH (cladding tube production) in Duisburg. The requirements of the U.S. market for light water reactor fuel elements are met by products from the European market. (orig.)
Drinfel'd basis of twisted Yangians
Belliard, Samuel
2014-01-01
We present a quantization of a Lie bi-ideal structure for twisted half-loop algebras of finite dimensional simple complex Lie algebras. We obtain Drinfel'd basis formalism and algebra closure relations of twisted Yangians for all symmetric pairs of simple Lie algebras and for simple twisted even half-loop Lie algebras. We also give an explicit form of twisted Yangians in Drinfel'd basis for the sl3 Lie algebra.
Properly twisted groups and their algebras
Bales, John W
2011-01-01
A twist property is developed which imparts certain properties on the twisted group algebra. These include an involution * satisfying (xy)*=y*x* and an inner product satisfying = and =. Examples of twisted group algebras having this property are the Cayley-Dickson algebras and Clifford algebras.
HTP X80管线钢的晶粒细化与组织控制%Grain Refinement and Microstructure Control of HTP X80 Pipeline Steel
Institute of Scientific and Technical Information of China (English)
缪成亮; 尚成嘉; 曹建平; 王学敏; 贺信莱
2009-01-01
通过热模拟实验研究了HTP X80管线钢的晶粒细化与组织控制的工艺要点,确定了奥氏体再结晶温度区和非再结晶温度区,揭示了高Nb含量的HTP钢在连续冷却过程中的相变特点.所得到的技术要点对细化奥氏体晶粒,避免混晶的出现,以及通过控制冷却得到理想的相变产物具有指导性.
The effects of 5-HT uptake- and MAO-inhibitors on L-5-HTP-induced excitation in rats.
Ortmann, R; Waldmeier, P C; Radeke, E; Felner, A; Delini-Stula, A
1980-03-01
The behavioural syndrome caused by L-5-HTP in rats was used for the study of effects of selective 5-HT uptake inhibitors and inhibitors of MAO on central 5-HT receptors. A good correlation was found between the relative potencies of drugs in inhibiting the 5-HT uptake in the rat brain and in intensifying L-5-HTP-induced behavioural stimulation. The potentiation of the L-5-HTP syndrome by the MAO inhibitors correlated with the inhibition of the A- but not of the B-form of the brain monoamine oxidase. In rats treated with the maximally inhibiting dose of a 5-HT uptake inhibitor, MAO inhibitors were still able to increase the intensity of the L-5-HTP syndrome, while the combination of maximal doses of two 5-HT uptake inhibitors did not produce a more intense syndrome than that produced by one 5-HT uptake inhibitor alone. The L-5-HTP-induced behavioural syndrome in rats seems to afford an experimental model allowing the quantification and characterization of the interaction of drugs with serotonin metabolism in the brain.
"Oliver Twist": A Teacher's Guide.
Cashion, Carol; Fischer, Diana
This teacher's guide for public television's 3-part adaptation of Charles Dickens's "Oliver Twist" provides information that will help enrich students' viewing of the series, whether or not they read the novel. The guide includes a wide range of discussion and activity ideas; there is also a series Web site and a list of Web resources.…
Helically twisted photonic crystal fibres.
Russell, P St J; Beravat, R; Wong, G K L
2017-02-28
Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic 'space', cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of 'numerical experiments' based on finite-element solutions of Maxwell's equations in a helicoidal frame.This article is part of the themed issue 'Optical orbital angular momentum'. © 2017 The Authors.
Helically twisted photonic crystal fibres
Russell, P. St. J.; Beravat, R.; Wong, G. K. L.
2017-02-01
Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic `space', cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of `numerical experiments' based on finite-element solutions of Maxwell's equations in a helicoidal frame. This article is part of the themed issue 'Optical orbital angular momentum'.
Helically twisted photonic crystal fibres
Beravat, R.; Wong, G. K. L.
2017-01-01
Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic ‘space’, cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of ‘numerical experiments’ based on finite-element solutions of Maxwell's equations in a helicoidal frame. This article is part of the themed issue ‘Optical orbital angular momentum’. PMID:28069771
Twisted Alexander polynomials of hyperbolic knots
Dunfield, Nathan M; Jackson, Nicholas
2011-01-01
We study a twisted Alexander polynomial naturally associated to a hyperbolic knot in an integer homology 3-sphere via a lift of the holonomy representation to SL(2, C). It is an unambiguous symmetric Laurent polynomial whose coefficients lie in the trace field of the knot. It contains information about genus, fibering, and chirality, and moreover is powerful enough to sometimes detect mutation. We calculated this invariant numerically for all 313,209 hyperbolic knots in S^3 with at most 15 crossings, and found that in all cases it gave a sharp bound on the genus of the knot and determined both fibering and chirality. We also study how such twisted Alexander polynomials vary as one moves around in an irreducible component X_0 of the SL(2, C)-character variety of the knot group. We show how to understand all of these polynomials at once in terms of a polynomial whose coefficients lie in the function field of X_0. We use this to help explain some of the patterns observed for knots in S^3, and explore a potential...
Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test.
Söderpalm, B; Hjorth, S; Engel, J A
1989-01-01
The effects of the pyrimidinyl-piperazines buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP) as well as of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and L-5-hydroxytryptophan (L-5-HTP) were investigated in Montgomery's conflict test--an animal anxiety model based on the animal's inborn urge to explore a new environment and its simultaneous fear of elevated, open spaces. Subcutaneous buspirone (32-128 nmol/kg), gepirone (32-128 nmol/kg), ipsapirone (32-512 nmol/kg) and 8-OH-DPAT (50-200 nmol/kg), as well as intraperitoneal L-5-HTP (56 mumol/kg) produced anxiolytic-like effects. However, at higher doses the magnitude of these effects decreased and overall the dose-response curves displayed inverted U-shapes. The highest doses (2048 nmol/kg) of buspirone and of gepirone even decreased responding below control levels, possibly in part due to concomitant sedation/motor impairment. After L-5-HTP (448 mumol/kg) and PmP (512 nmol/kg) anxiogenic-like effects were observed. The results indicate that anxiolytic- and anxiogenic-like effects of drugs affecting central serotonergic neurotransmission can be obtained in a sensitive rat anxiety model which neither involves consummatory behavior nor punishment. The anxiolytic-like effects of these compounds may be due to their 5-HT1A agonistic properties. Moreover, the present data may provide support for a possible reciprocal association of presynaptic 5-HT1A receptors vs. postsynaptic 5-HT1A as well as 5-HT2 receptors with regard to anxiety.
Sargent, P A; Quested, D J; Cowen, P J
1998-11-01
We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT2 receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT2 receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT2 receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction.
Gendle, Mathew H; Golding, Abbe C
2010-08-01
Although the serotonin precursor 5-hydroxytryptophan (5-HTP) is marketed as a psychoactive nutritional supplement, knowledge is limited regarding the effects of exogenous 5-HTP on brain activity. This study examined if oral administration of 5-HTP to healthy adults impacted: (1) mood states, as measured by the Profile of Mood States (POMS); and (2) performance on the Iowa Gambling Task (IGT), a measure sensitive to alterations in frontocortical serotonin levels. A sample of 46 undergraduates participated, and each received either two 50 mg 5-HTP capsules or placebos, and completed the IGT and POMS following an absorption period. 5-HTP did not significantly alter mood states, but did impair performance on the IGT. Specifically, the 5-HTP group performed more poorly than the placebo group during the first 20 trials of the IGT but did not differ from the placebo group on trials 21-100. This suggests that oral 5-HTP specifically impaired decision making under ambiguity but not under risk. Males also performed more poorly on the first 20 trials of the IGT, regardless of treatment group. Oral 5-HTP is psychoactive at low doses. Decisions made under ambiguity may be differentially sensitive to increased serotonin release or associated reductions in frontocortical dopamine activity. Copyright 2010 John Wiley & Sons, Ltd.
Orlefors, Håkan; Sundin, Anders; Eriksson, Barbro; Skogseid, Britt; Oberg, Kjell; Akerström, Göran; Hellman, Per
2012-02-08
Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower.
Örlefors, Håkan; Sundin, Anders; Eriksson, Barbro; Skogseid, Britt; Öberg, Kjell; Åkerström, Göran; Hellman, Per
2012-01-01
Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower. PMID:24213229
Directory of Open Access Journals (Sweden)
Barbro Eriksson
2012-02-01
Full Text Available Positron emission tomography (PET with 11C-labeled 5-hydroxytryptophane (5-HTP is a sensitive technique to visualize neuroendocrine tumours (NETs, due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower.
Renormalization constants for 2-twist operators in twisted mass QCD
Alexandrou, C; Korzec, T; Panagopoulos, H; Stylianou, F
2010-01-01
Perturbative and non-perturbative results on the renormalization constants of the fermion field and the twist-2 fermion bilinears are presented with emphasis on the non-perturbative evaluation of the one-derivative twist-2 vector and axial vector operators. Non-perturbative results are obtained using the twisted mass Wilson fermion formulation employing two degenerate dynamical quarks and the tree-level Symanzik improved gluon action. The simulations have been performed for pion masses in the range of about 450-260 MeV and at three values of the lattice spacing $a$ corresponding to $\\beta=3.9, 4.05, 4.20$. Subtraction of ${\\cal O}(a^2)$ terms is carried out by performing the perturbative evaluation of these operators at 1-loop and up to ${\\cal O}(a^2)$. The renormalization conditions are defined in the RI$'$-MOM scheme, for both perturbative and non-perturbative results. The renormalization factors, obtained for different values of the renormalization scale, are evolved perturbatively to a reference scale set...
Fariselli, P; Casadio, R
1996-02-01
In this paper we describe a microcomputer program (HTP) for predicting the location and orientation of alpha-helical transmembrane segments in integral membrane proteins. HTP is a neural network-based tool which gives as output the protein membrane topology based on the statistical propensity of residues to be located in external and internal loops. This method, which uses single protein sequences as input to the network system, correctly predicts the topology of 71 out of 92 membrane proteins of putative membrane orientation, independently of the protein source.
The twist box domain is required for Twist1-induced prostate cancer metastasis.
Gajula, Rajendra P; Chettiar, Sivarajan T; Williams, Russell D; Thiyagarajan, Saravanan; Kato, Yoshinori; Aziz, Khaled; Wang, Ruoqi; Gandhi, Nishant; Wild, Aaron T; Vesuna, Farhad; Ma, Jinfang; Salih, Tarek; Cades, Jessica; Fertig, Elana; Biswal, Shyam; Burns, Timothy F; Chung, Christine H; Rudin, Charles M; Herman, Joseph M; Hales, Russell K; Raman, Venu; An, Steven S; Tran, Phuoc T
2013-11-01
Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial-mesenchymal transition (EMT) that promotes cancer metastasis. Structure-function relationships of Twist1 to cancer-related phenotypes are underappreciated, so we studied the requirement of the conserved Twist box domain for metastatic phenotypes in prostate cancer. Evidence suggests that Twist1 is overexpressed in clinical specimens and correlated with aggressive/metastatic disease. Therefore, we examined a transactivation mutant, Twist1-F191G, in prostate cancer cells using in vitro assays, which mimic various stages of metastasis. Twist1 overexpression led to elevated cytoskeletal stiffness and cell traction forces at the migratory edge of cells based on biophysical single-cell measurements. Twist1 conferred additional cellular properties associated with cancer cell metastasis including increased migration, invasion, anoikis resistance, and anchorage-independent growth. The Twist box mutant was defective for these Twist1 phenotypes in vitro. Importantly, we observed a high frequency of Twist1-induced metastatic lung tumors and extrathoracic metastases in vivo using the experimental lung metastasis assay. The Twist box was required for prostate cancer cells to colonize metastatic lung lesions and extrathoracic metastases. Comparative genomic profiling revealed transcriptional programs directed by the Twist box that were associated with cancer progression, such as Hoxa9. Mechanistically, Twist1 bound to the Hoxa9 promoter and positively regulated Hoxa9 expression in prostate cancer cells. Finally, Hoxa9 was important for Twist1-induced cellular phenotypes associated with metastasis. These data suggest that the Twist box domain is required for Twist1 transcriptional programs and prostate cancer metastasis. Targeting the Twist box domain of Twist1 may effectively limit prostate cancer metastatic potential. ©2013 AACR.
"Twisted" black holes are unphysical
Gray, Finnian; Schuster, Sebastian; Visser, Matt
2016-01-01
So-called "twisted" black holes have recently been proposed by Zhang (1609.09721 [gr-qc]), and further considered by Chen and Jing (1610.00886 [gr-qc]), and more recently by Ong (1610.05757 [gr-qc]). While these spacetimes are certainly Ricci-flat, and so mathematically satisfy the vacuum Einstein equations, they are also merely minor variants on Taub--NUT spacetimes. Consequently they exhibit several unphysical features that make them quite unreasonable as realistic astrophysical objects. Specifically, these "twisted" black holes are not (globally) asymptotically flat. Furthermore, they contain closed timelike curves that are not hidden behind any event horizon --- the most obvious of these closed timelike curves are small azimuthal circles around the rotation axis, but the effect is more general. The entire region outside the horizon is infested with closed timelike curves.
Polarization twist in perovskite ferrielectrics
Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro
2016-01-01
Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of ‘polarization twist’, which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms. PMID:27586824
Polarization twist in perovskite ferrielectrics
Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro
2016-09-01
Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of ‘polarization twist’, which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms.
Twisted Chern-Simons supergravity
Energy Technology Data Exchange (ETDEWEB)
Castellani, L. [Dipartimento di Scienze e Innovazione Tecnologica, Univ. del Piemonte Orientale, Alessandria (Italy); INFN Gruppo collegato di Alessandria (Italy)
2014-09-11
We present a noncommutative version of D = 5 Chern-Simons supergravity, where noncommutativity is encoded in a *-product associated to an abelian Drinfeld twist. The theory is invariant under diffeomorphisms, and under the *-gauge supergroup SU(2,2 vertical stroke 4), including Lorentz and N = 4 local supersymmetries. (Copyright copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)
Counting Polyominoes on Twisted Cylinders
Barequet, Gill; Moffie, Micha; Ribó, Ares; Rote, Günter
2005-01-01
International audience; We improve the lower bounds on Klarner's constant, which describes the exponential growth rate of the number of polyominoes (connected subsets of grid squares) with a given number of squares. We achieve this by analyzing polyominoes on a different surface, a so-called $\\textit{twisted cylinder}$ by the transfer matrix method. A bijective representation of the "states'' of partial solutions is crucial for allowing a compact representation of the successive iteration vec...
Comparison of effects of Idazoxan and 5-HTP on anxiety with Chlordiazepoxide
Directory of Open Access Journals (Sweden)
Alaiy H
1997-08-01
Full Text Available We studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-HTP on anxiety-related behavior in rats. The conflict drinking test, and evaluator plus-maze were used as model. Idazoxan (2 mg/kg showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-HTP showed that anxiolytic-like effect in both models. This drug reversed action and produced anxiogenic-like effect at high doses. In contrast, arecholine which is a cholinergic muscarinic agonist drug, produced anxiogenic-like behavior. At 2 mg/kg increased number of entrance (OE and using time (OT in open arms in montgomery's test. Anxiolytic-like effect of this drug was less than of chlordizepoxide. These results showed that increase release of noradrenaline in synaptic nerve terminals of neurons produced anxiety-related behavior. While high release of serotonin in this area reduced behaviors disorder in rats.
Evaluation of MBEC™-HTP biofilm model for studies of implant associated infections.
Coraça-Hubér, Debora C; Fille, Manfred; Hausdorfer, Johann; Pfaller, Kristian; Nogler, Michael
2012-07-01
The bacteria in implant-related infections can evade host defenses by forming biofilms. The more we understand biofilm behavior, the better we can fight against then clinically. In vitro models for biofilms allow tests simulating in vivo conditions. In this study we evaluated the Minimum Biofilm Eradication Concentration-High Throughput Plates (MBEC™-HTP) as biofilm in vitro model for studies of implant associated infections. Staphylococcus aureus and Staphylococcus epidermidis biofilms were grown on MBEC™-HTP. To ensure the biofilm formation, antibiotic susceptibility tests and scanning electron microscopy (SEM) was carried out. Susceptibility tests were carried out using gentamicin, vancomycin, rifampicin, fosfomycin, clindamycin, and linezolid. Colony forming units counting were carried out. Minimal inhibitory concentration (MIC) and biofilm inhibitory concentration (BIC) were estimated. The CFU counting showed potency of rifampicin and daptomycin against S. epidermidis biofilms and rifampicin against S. aureus biofilms. SEM images showed proteic material in contact with cells. The differences between BIC and MIC demonstrated the biofilm formation as well as the SEM images. Rifampicin and daptomycin are good choices against biofilm related infections. Moreover, after suggested modifications, the model used in this study is eligible to further studies of implant associated infections. Copyright © 2012 Orthopaedic Research Society.
R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram.
Sánchez, Connie; Kreilgaard, Mads
2004-02-01
Escitalopram mediates the serotonin re-uptake inhibitory and antidepressant effect of citalopram racemate. However, recent studies have shown that R-citalopram inhibits the escitalopram-induced increase of extracellular 5-HT levels in the frontal cortex of rats. Here, we investigated the inhibitory effect of R-citalopram on the escitalopram-induced increase of 5-HT neurotransmission at the behavioural [potentiation of 5-hydroxytryptophan (5-HTP)-induced behavioural changes in mice and rats] and functional (increase in serum corticosterone in rats) levels. The effect of escitalopram was inhibited by R-citalopram in all three models, and R-citalopram, given alone, was inactive. The effects were more pronounced using an escitalopram to R-citalopram ratio of 1:4 than ratios of 1:2 and 1:1, suggesting a dose-dependent effect. The ED(50)-value of escitalopram in mouse 5-HTP potentiation studies corresponded to a serum concentration of approximately 50 ng/ml, which can be considered to be in the range of clinically relevant serum concentrations. In conclusion, R-citalopram inhibited the escitalopram-induced increase of 5-HT activity in functional, as well as behavioural, animal models. The mechanism involved in this interaction is currently unknown, but may be related to an improved clinical effect seen with escitalopram in comparison with citalopram.
New twist on artificial muscles
Haines, Carter S.; Li, Na; Spinks, Geoffrey M.; Aliev, Ali E.; Di, Jiangtao; Baughman, Ray H.
2016-01-01
Lightweight artificial muscle fibers that can match the large tensile stroke of natural muscles have been elusive. In particular, low stroke, limited cycle life, and inefficient energy conversion have combined with high cost and hysteretic performance to restrict practical use. In recent years, a new class of artificial muscles, based on highly twisted fibers, has emerged that can deliver more than 2,000 J/kg of specific work during muscle contraction, compared with just 40 J/kg for natural muscle. Thermally actuated muscles made from ordinary polymer fibers can deliver long-life, hysteresis-free tensile strokes of more than 30% and torsional actuation capable of spinning a paddle at speeds of more than 100,000 rpm. In this perspective, we explore the mechanisms and potential applications of present twisted fiber muscles and the future opportunities and challenges for developing twisted muscles having improved cycle rates, efficiencies, and functionality. We also demonstrate artificial muscle sewing threads and textiles and coiled structures that exhibit nearly unlimited actuation strokes. In addition to robotics and prosthetics, future applications include smart textiles that change breathability in response to temperature and moisture and window shutters that automatically open and close to conserve energy. PMID:27671626
Design studies for twist-coupled wind turbine blades.
Energy Technology Data Exchange (ETDEWEB)
Valencia, Ulyses (Wichita State University, Wichita, KS); Locke, James (Wichita State University, Wichita, KS)
2004-06-01
This study presents results obtained for four hybrid designs of the Northern Power Systems (NPS) 9.2-meter prototype version of the ERS-100 wind turbine rotor blade. The ERS-100 wind turbine rotor blade was designed and developed by TPI composites. The baseline design uses e-glass unidirectional fibers in combination with {+-}45-degree and random mat layers for the skin and spar cap. This project involves developing structural finite element models of the baseline design and carbon hybrid designs with and without twist-bend coupling. All designs were evaluated for a unit load condition and two extreme wind conditions. The unit load condition was used to evaluate the static deflection, twist and twist-coupling parameter. Maximum deflections and strains were determined for the extreme wind conditions. Linear and nonlinear buckling loads were determined for a tip load condition. The results indicate that carbon fibers can be used to produce twist-coupled designs with comparable deflections, strains and buckling loads to the e-glass baseline.
Distribution of SpHtp 1 gene among different Saprolegnia strains%SpHtp1基因在不同种属水霉菌株中的分布
Institute of Scientific and Technical Information of China (English)
叶鑫; 赵依妮; 曹海鹏; 胡鲲; 杨先乐
2014-01-01
In order to understand the distribution of the Sp Htp 1 gene among different saprolegnia strains,using Saprolegnia parasitica (ATCC200013 TM )genomic DNA as the template,a pair of gene-specific primers was designed,a PCR method was developed and the parameters for PCR amplification was optimized.The PCR product was extracted,linked into pMD18-T vector and then cloned into E .coli DH5α.The recombination plasmid was identified by PCR and sequenced to prove the amplification of the target gene.As a result,a 224 bp DNA fragment of the Sp Htp 1 gene can be amplified from the sapro-legnia genome,which had an identity of 99% in sequence with that of other Saprolegnia strains.Addi-tionally,17 samples from all over China were tested using this method and the Sp Htp 1 gene was present in 8 (47%)samples.The results indicated that the Sp Htp 1 gene is expressed specifically in S .parasiti-ca ,which can be used potentially for detection of Saprolegnia .%为研究 Sp Htp 1基因在不同种属水霉菌株中的分布，以寄生水霉 ATCC200013 TM 的基因组 DNA 为模板，设计1对特异性引物，进行 PCR 扩增。将扩增片段回收，并克隆入 T 载体，转化大肠杆菌 DH5α，挑取阳性克隆测序。将测序结果与 GenBank 中登录的 Sp Htp 1基因序列进行比较，同源性为99%。以该方法调查从水霉病主要流行地区分离的17株水霉菌 Sp Htp 1基因的分布情况，结果发现：在17株水霉菌株中，有8株水霉菌检测到 Sp Htp 1基因，阳性率为47%，且所有含 Sp Htp 1基因的菌株在分类地位上均隶属于寄生水霉(Sapro-legnia parasitica )。Sp Htp 1基因可能在寄生水霉中特异性存在，该基因有望用于寄生水霉的分离鉴定。
Noncommutative principal bundles through twist deformation
Aschieri, Paolo; Pagani, Chiara; Schenkel, Alexander
2016-01-01
We construct noncommutative principal bundles deforming principal bundles with a Drinfeld twist (2-cocycle). If the twist is associated with the structure group then we have a deformation of the fibers. If the twist is associated with the automorphism group of the principal bundle, then we obtain noncommutative deformations of the base space as well. Combining the two twist deformations we obtain noncommutative principal bundles with both noncommutative fibers and base space. More in general, the natural isomorphisms proving the equivalence of a closed monoidal category of modules and its twist related one are used to obtain new Hopf-Galois extensions as twists of Hopf-Galois extensions. A sheaf approach is also considered, and examples presented.
The Twist Limit for Bipolar Active Regions
Moore, Ron; Falconer, David; Gary, Allen
2008-01-01
We present new evidence that further supports the standard idea that active regions are emerged magnetic-flux-rope omega loops. When the axial magnetic twist of a cylindrical flux rope exceeds a critical amount, the flux rope becomes unstable to kinking, and the excess axial twist is converted into writhe twist by the kinking. This suggests that, if active regions are emerged omega loops, then (1) no active region should have magnetic twist much above the limit set by kinking, (2) active regions having twist near the limit should often arise from kinked omega loops, and (3) since active regions having large delta sunspots are outstandingly twisted, these arise from kinked omega loops and should have twist near the limit for kinking. From each of 36 vector magnetograms of bipolar active regions, we have measured (1) the total flux of the vertical field above 100 G, (2) the area covered by this flux, and (3) the net electric current that arches over the polarity inversion line. These three quantities yield an estimate of the axial magnetic twist in a simple model cylindrical flux rope that corresponds to the top of the active region s hypothetical omega loop prior to emergence. In all 36 cases, the estimated twist is below the critical limit for kinking. The 11 most twisted active regions (1) have estimated twist within a factor of approx.3 of the limit, and (2) include all of our 6 active regions having large delta sunspots. Thus, our observed twist limit for bipolar active regions is in good accord with active regions being emerged omega loops.
Lambeth, Pauline J.
Finding innovative and effective methods to infer the ability of culturally diverse students continues to present a problem for educators. This paper proposes the House-Tree-Person (HTP) projective technique as a way for school educators to gather important data about student functioning without the use of culturally biased instruments. This…
National Research Council Canada - National Science Library
Ogliari, Juliana Bernardi; Guimarães, Marco Antônio; Camargo, Luis Eduardo Aranha
2007-01-01
...) L30HtPHtPRtRt and L30htphtpRtRt and the L40htphtprtrt line which contrast regarding the presence of the recently described dominant HtP and the recessive rt genes that confer resistance to Exserohilum turcicum...
Emmers, R; Tamir, H; Wilchek, M
1989-06-01
This study was designed to pinpoint the site at which N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (5-HTP-DP-hex) exerts its previously reported effect on thalamic neurons in rats. The animals were prepared under chloralose-urethane anesthesia for a stereotaxic approach to either the nucleus ventralis posterolateralis (nVPL) or the centrum medianum-parafascicularis complex (CM-Pf) of the thalamus. Individual neurons in these nuclei were separately activated by single-pulse stimulation of the sciatic nerve or the thalamic fibers that form reciprocal connections between the CM-Pf and the second somatosensory (SII) region of the nVPL. Poststimulus time histograms were constructed from computer readouts of the stimulus-evoked responses of a neuron during a 500-ms period accumulated in a digital computer 100X. In addition, the number of spikes accumulated in each histogram was compared to the number of spikes accumulated under identical conditions on the same neuron after intracarotid infusion of 5-HTP-DP-hex. The effect of the drug was reversed by the infusion of 5-HTP. Statistical evaluation of the accumulated spike counts indicated that 5-HTP-DP-hex suppressed only the excitation of CM-Pf neurons from the SII of the nVPL; the input of the sciatic nerve into the CM-Pf remained unaltered. Furthermore, no effect was exerted by this dipeptide on the afferent excitation of neurons in the SII of the nVPL.(ABSTRACT TRUNCATED AT 250 WORDS)
Sallanon, M; Buda, C; Janin, M; Jouvet, M
1982-08-13
When injected intraperitoneally (i.p.) into normal cats, methiothepin (1-7.5 mg/kg) or metergoline (0.5-8 mg/kg) induced total insomnia. The duration of suppression of deep slow-wave sleep (SWS2) and paradoxical sleep (PS) was dose-related for methiothepin (10-30 h), but was shorter and not dose-related for metergoline (3-5 h). When injected into the fourth ventricle, methiothepin (20 microgram) induced a selective suppression of PS for 6-7 h). In rho-chlorophenyl-alanine (PCPA)-pretreated, insomniac cats, i.p. injection of 5 mg/kg of DL-5-hydroxytryptophan(5-HTP) was followed by SWS and PS after latencies of 25 and 62 min. When methiothepin (2.5 mg/kg) or metergoline (4 mg/kg) were given before 5-HTP, the latency for the first PS episode increased dramatically to 7 h. Thereafter PS occurred periodically for 10 h but no SWS appeared. These results suggest that a 'PS factor' induced by 5-HTP and different from indolamines is preserved during the antagonistic effect of methiothepin or metergoline until it can act upon the executive mechanisms of PS. Our data also suggest that metergoline and methiothepin suppress but do not delay the mechanism responsible for SWS2 in the PCPA-5-HTP paradigm.
Kälkner, K M; Ginman, C; Nilsson, S; Bergström, M; Antoni, G; Ahlström, H; Långström, B; Westlin, J E
1997-05-01
The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in neuroendocrine tumours using the PET technique, this tracer was applied in the study of 10 patients with metastatic hormone-refractory prostatic adenocarcinoma. In three patients, the study was repeated after treatment. An increased uptake of 11C-5-HTP was observed in all investigated skeletal lesions, although the magnitude of the uptake was moderate. The difference between the standard uptake values (SUV) in normal bone and metastatic lesions was significant (p HTP demonstrates an increase during the first minutes followed by a wash-out and a stabilization of the tissue/blood ratio at about 2. The Patlak plots demonstrated a gradual increase in the transport rate during the first 20 to 30 min, after which a constant level was observed. The SUV varied between patients and between lesions over time and treatment. The uptake of 11C-5-HTP discriminates metastatic lesions from normal bone and may thus aid in the diagnosis and, potentially, in treatment monitoring of metastatic hormone-refractory prostatic adenocarcinoma. Uptake kinetics are characterized by a wash-out and cannot alone be used as proof of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma.
Lambeth, Pauline J.
Finding innovative and effective methods to infer the ability of culturally diverse students continues to present a problem for educators. This paper proposes the House-Tree-Person (HTP) projective technique as a way for school educators to gather important data about student functioning without the use of culturally biased instruments. This…
Kuusk, Priit, 1938-
2000-01-01
Helsingi uue muusika festivalist "Musica Nova" 3.-11. märtsini. Möödus sajand S. Revueltase sünnist, tähtpäeva üritustest USAs. MIDEMi muusikamess Cannes'is andis viiendat korda välja eriauhinna väljapaistvale kaasaja heliloojale ئ seekord K. Pendereckile
Kuusk, Priit, 1938-
2000-01-01
Helsingi uue muusika festivalist "Musica Nova" 3.-11. märtsini. Möödus sajand S. Revueltase sünnist, tähtpäeva üritustest USAs. MIDEMi muusikamess Cannes'is andis viiendat korda välja eriauhinna väljapaistvale kaasaja heliloojale ئ seekord K. Pendereckile
Twisted Savonius turbine based marine current energy conversion system
Hassan, Md. Imtiaj
The Ocean Network Seafloor Instrumentation (ONSFI) Project is a multidisciplinary research and development project that aims to design, fabricate and validate a proof-of-concept seafloor array of wireless marine sensors for use in monitoring seabed processes. The sensor pods, known as Seaformatics, will be powered by ocean bottom currents and will be able to communicate with each other and to the Internet through surface master units to facilitate observation of the ocean floor from the shore. This thesis explores the use of the twisted Savonius turbine as a means of converting the kinetic energy of the free flowing water into electrical energy for the pods. This will eliminate the need for battery replacement. A physical model of the turbine was constructed and tested in the Water Flume at the Marine Institute of Memorial University and in the Wind Tunnel in the Engineering Building at Memorial University. A mathematical model of the turbine was constructed in SolidWorks. This was tested in the Computational Fluid Dynamics or CFD software FLOW-3D. Experimental results were compared with CFD results and the agreement was reasonable. A twisted Savonius turbine emulator was developed to test a dc-dc boost converter. A low cost microcontroller based MPPT algorithm was developed to obtain maximum power from the turbine. Overall the thesis shows that the twisted Savonius turbine can provide the power needed by the sensor pods. It also shows that CFD is a viable way to study the performance of the Savonius type of turbine.
DVCS amplitude with kinematical twist-3 terms
Radyushkin, A V
2000-01-01
We compute the amplitude of deeply virtual Compton scattering (DVCS) using the calculus of QCD string operators in coordinate representation. To restore the electromagnetic gauge invariance (transversality) of the twist-2 amplitude we include the operators of twist-3 which appear as total derivatives of twist-2 operators. Our results are equivalent to a Wandzura-Wilczek approximation for twist-3 skewed parton distributions. We find that this approximation gives a finite result for the amplitude of a longitudinally polarized virtual photon, while the amplitude for transverse polarization is divergent, i.e., factorization breaks down in this term.
Park, Seyong; Yoon, Young-Man; Han, Seong Kuk; Kim, Daegi; Kim, Ho
2017-06-01
This study is an assessment of the hydrothermal pre-treatment (HTP) of poultry slaughterhouse waste (PSW) sludge for the enhancement of the solubilization, physical properties, and biogas production through anaerobic digestion. This assessment was carried out to ascertain the optimal HTP temperature. The solubilization and physical properties efficacy was investigated by capillary suction time (CST), time to filter (TTF), and particle size. In addition, the anaerobic digestion was investigated through biochemical methane potential (BMP) tests and subsequent statistical analysis using the modified Gompertz model. HTP was found to have improved the solubilization of the PSW sludge with increasing HTP temperature. In addition, the results of the CST, TTF, and particle size decreased with increasing HTP temperature. These results of the assessment that was conducted in this study confirm that the HTP process indeed modifies the physical properties of PSWs to enhance the solubilization of organic solids. Nevertheless, the results of the BMP tests and the modified Gompertz model analysis show that the optimal HTP temperature of PSWs for anaerobic digestion is 190°C. These findings show that to achieve high conversion efficiency, an accurately designed pre-treatment step must be included in the overall anaerobic digestion process for wastewater treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.
Li, Yaqing; Li, Lisa; Stephens, Marilee J; Zenner, Dwight; Murray, Katherine C; Winship, Ian R; Vavrek, Romana; Baker, Glen B; Fouad, Karim; Bennett, David J
2014-01-01
Spinal cord transection leads to elimination of brain stem-derived monoamine fibers that normally synthesize most of the monoamines in the spinal cord, including serotonin (5-hydroxytryptamine, 5-HT) synthesized from tryptophan by enzymes tryptophan hydroxylase (TPH, synthesizing 5-hydroxytryptophan, 5-HTP) and aromatic l-amino acid decarboxylase (AADC, synthesizing 5-HT from 5-HTP). Here we examine whether spinal cord caudal to transection remains able to manufacture and metabolize 5-HT. Immunolabeling for AADC reveals that, while most AADC is confined to brain stem-derived monoamine fibers in spinal cords from normal rats, caudal to transection AADC is primarily found in blood vessel endothelial cells and pericytes as well as a novel group of neurons (NeuN positive and GFAP negative), all of which strongly upregulate AADC with injury. However, immunolabeling for 5-HT reveals that there is no detectable endogenous 5-HT synthesis in any structure in the spinal cord caudal to a chronic transection, including in AADC-containing vessels and neurons, consistent with a lack of TPH. In contrast, when we applied exogenous 5-HTP (in vitro or in vivo), AADC-containing vessels and neurons synthesized 5-HT, which contributed to increased motoneuron activity and muscle spasms (long-lasting reflexes, LLRs), by acting on 5-HT2 receptors (SB206553 sensitive) located on motoneurons (TTX resistant). Blocking monoamine oxidase (MAO) markedly increased the sensitivity of the motoneurons (LLR) to 5-HTP, more than it increased the sensitivity of motoneurons to 5-HT, suggesting that 5-HT synthesized from AADC is largely metabolized in AADC-containing neurons and vessels. In summary, after spinal cord injury AADC is upregulated in vessels, pericytes, and neurons but does not endogenously produce 5-HT, whereas when exogenous 5-HTP is provided AADC does produce functional amounts of 5-HT, some of which is able to escape metabolism by MAO, diffuse out of these AADC-containing cells, and
Skarsfeldt, T; Arnt, J; Hyttel, J
1990-02-06
Different serotonin (5-HT) receptor agonists were tested on the electrically stimulated flexor reflex in pithed rats. The 5-HT2 receptor agonist, (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) [+/-)DOI), the mixed 5-HT1/5-HT2 receptor agonist, quipazine, and the 5-HT precursor, l-5-HTP, showed agonistic activity upon intravenous injection while 5-HT was without effect. A combination of the peripheral decarboxylase inhibitor, Ro 4-4602 (benzerazide), the specific 5-HT-uptake inhibitor, citalopram, and l-5-HTP induced a prolonged (greater than 3 h) increase of the flexor reflex in pithed rats. Different compounds were tested for an inhibitory effect against this l-5-HTP-induced flexor reflex. The 5-HT2 antagonists (ketanserin, methergoline and methiothepin) were potent antagonists. (-)Alprenolol (5-HT1A and 5-HT1B receptor antagonist) and the 5-HT3-receptor antagonist, ICS 205-930, were without an antagonistic effect. The inhibitory potencies in the reflex model (l-5-HTP, citalopram and Ro 4-4602) were significantly correlated (r = 0.83, P less than 0.01, r2 = 0.69) with the potencies to inhibit l-5-HTP-induced head twitches and quipazine-induced head twitches (r = 0.81, P less than 0.01, r2 = 0.66). There was less correlation (r = 0.75, P less than 0.01, r2 = 0.56) with the affinities for 5-HT2 receptors in vitro. There was no significant correlation between inhibitory potencies in the reflex model and affinities for dopamine (DA) D-2 receptors or alpha 1-adrenoceptors (r2 = 0.13 and 0.14, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Twisted conjugacy in braid groups
González-Meneses, Juan
2011-01-01
In this note we solve the twisted conjugacy problem for braid groups, i.e. we propose an algorithm which, given two braids $u,v\\in B_n$ and an automorphism $\\phi \\in Aut (B_n)$, decides whether $v=(\\phi (x))^{-1}ux$ for some $x\\in B_n$. As a corollary, we deduce that each group of the form $B_n \\rtimes H$, a semidirect product of the braid group $B_n$ by a torsion-free hyperbolic group $H$, has solvable conjugacy problem.
ANL/HTP: a computer code for the simulation of heat pipe operation
Energy Technology Data Exchange (ETDEWEB)
McLennan, G.A.
1983-11-01
ANL/HTP is a computer code for the simulation of heat pipe operation, to predict heat pipe performance and temperature distributions during steady state operation. Source and sink temperatures and heat transfer coefficients can be set as input boundary conditions, and varied for parametric studies. Five code options are included to calculate performance for fixed operating conditions, or to vary any one of the four boundary conditions to determine the heat pipe limited performance. The performance limits included are viscous, sonic, entrainment capillary, and boiling, using the best available theories to model these effects. The code has built-in models for a number of wick configurations - open grooves, screen-covered grooves, screen-wrap, and arteries, with provision for expansion. The current version of the code includes the thermophysical properties of sodium as the working fluid in an expandable subroutine. The code-calculated performance agrees quite well with measured experiment data.
Ketov, Sergei V.; Lechtenfeld, Olaf; Parkes, Andrew J.
1995-03-01
The most general homogeneous monodromy conditions in N=2 string theory are classified in terms of the conjugacy classes of the global symmetry group U(1,1)⊗openZ2. For classes which generate a discrete subgroup Γ, the corresponding target space backgrounds openC1,1/Γ include half spaces, complex orbifolds, and tori. We propose a generalization of the intercept formula to matrix-valued twists, but find massless physical states only for Γ=open1 (untwisted) and Γ=openZ2 (in the manner of Mathur and Mukhi), as well as for Γ being a parabolic element of U(1,1). In particular, the 16 openZ2-twisted sectors of the N=2 string are investigated, and the corresponding ground states are identified via bosonization and BRST cohomology. We find enough room for an extended multiplet of ``spacetime'' supersymmetry, with the number of supersymmetries being dependent on global ``spacetime'' topology. However, world-sheet locality for the chiral vertex operators does not permit interactions among all massless ``spacetime'' fermions.
Symmetry fractionalization and twist defects
Tarantino, Nicolas; Lindner, Netanel H.; Fidkowski, Lukasz
2016-03-01
Topological order in two-dimensions can be described in terms of deconfined quasiparticle excitations—anyons—and their braiding statistics. However, it has recently been realized that this data does not completely describe the situation in the presence of an unbroken global symmetry. In this case, there can be multiple distinct quantum phases with the same anyons and statistics, but with different patterns of symmetry fractionalization—termed symmetry enriched topological order. When the global symmetry group G, which we take to be discrete, does not change topological superselection sectors—i.e. does not change one type of anyon into a different type of anyon—one can imagine a local version of the action of G around each anyon. This leads to projective representations and a group cohomology description of symmetry fractionalization, with the second cohomology group {H}2(G,{{ A }}{{abelian}}) being the relevant group. In this paper, we treat the general case of a symmetry group G possibly permuting anyon types. We show that despite the lack of a local action of G, one can still make sense of a so-called twisted group cohomology description of symmetry fractionalization, and show how this data is encoded in the associativity of fusion rules of the extrinsic ‘twist’ defects of the symmetry. Furthermore, building on work of Hermele (2014 Phys. Rev. B 90 184418), we construct a wide class of exactly-solvable models which exhibit this twisted symmetry fractionalization, and connect them to our formal framework.
Multiple Twisted -Euler Numbers and Polynomials Associated with -Adic -Integrals
Directory of Open Access Journals (Sweden)
Jang Lee-Chae
2008-01-01
Full Text Available By using -adic -integrals on , we define multiple twisted -Euler numbers and polynomials. We also find Witt's type formula for multiple twisted -Euler numbers and discuss some characterizations of multiple twisted -Euler Zeta functions. In particular, we construct multiple twisted Barnes' type -Euler polynomials and multiple twisted Barnes' type -Euler Zeta functions. Finally, we define multiple twisted Dirichlet's type -Euler numbers and polynomials, and give Witt's type formula for them.
Further understanding of twisted tape effects as tube insert for heat transfer enhancement
Abu-Khader, Mazen M.
2006-12-01
Tube inserts are used as heat transfer enhancement tool for both retrofit and new design of shell and tube heat exchangers. This paper discusses and reviews the characteristics and performance of twisted tapes. The theory and application are also addressed. Industrial case study was selected to illustrate the behaviour effect that the twisted tapes impose at various laminar, transition and turbulent flow regions. This effect was demonstrated by changing the inside tube diameter and twist ratio through evaluating selected exchanger design parameters such as: local heat transfer coefficient, friction factor and pressure drop. Testing the exponent powers for Re and Pr at both laminar and turbulent regions were carried out. General design considerations are outlined for the use of twisted tapes in shell and tube heat exchangers.
Large N reduction on a twisted torus
González-Arroyo, A; Neuberger, H
2005-01-01
We consider SU(N) lattice gauge theory at infinite N defined on a torus with a CP invariant twist. Massless fermions are incorporated in an elegant way, while keeping them quenched. We present some numerical results which suggest that twisting can make numerical simulations of planar QCD more efficient.
Stress effects in twisted highly birefringent fibers
Wolinski, Tomasz R.
1994-03-01
Hydrostatic pressure and uniaxial longitudinal strain effects in twisted highly birefringent optical fibers have been investigated from the point of the Marcuse mode-coupling theory. The problem is analyzed in terms of local normal modes of the ideal fiber and in the limit of weak twist, where large linear birefringence dominates over twist effect, and therefore twist coupling between local modes is not effective. The authors present the results of birefringence measurements in highly birefringent bow-tie fibers influenced simultaneously by hydrostatic pressure up to 100 MPa and twisting the result for highly birefringent elliptical-core fibers influenced by uniaxial longitudinal strain up to 4000 (mu) (epsilon) and twisting effect. The birefringence measurement method is based on twist-induced effects and has been successfully applied in a stress environment. The experiment was conducted with a specially designed stress generating device that makes it possible to simultaneously generate various mechanical perturbations such as hydrostatic and radial pressure, axial strain and twist, allowing study of their influence on mode propagation in optical fibers. A comparison with theoretical results as well as with pervious experimental data on stress influence on the beat length parameter in highly birefringent fibers is also provided.
Decay constants from twisted mass QCD
Dimopoulos, P; Michael, C; Simula, S; Urbach, C
2008-01-01
We present results for chiral extrapolations of the mass and decay constants of the rho meson. The data sets used are the nf=2 unquenched gauge configurations generated with twisted mass fermions by the European Twisted Mass Collaboration. We describe a calculation of three decay constants in charmonium and explain why they are required.
Twisting theory for weak Hopf algebras
Institute of Scientific and Technical Information of China (English)
CHEN Ju-zhen; ZHANG Yan; WANG Shuan-hong
2008-01-01
The main aim of this paper is to study the twisting theory of weak Hopf algebras and give an equivalence between the (braided) monoidal categories of weak Hopf bimodules over the original and the twisted weak Hopf algebra to generalize the result from Oeckl (2000).
Kato, J; Miyake, A; Kato, Junji; Kawamoto, Noboru; Miyake, Akiko
2005-01-01
We propose N=4 twisted superspace formalism in four dimensions by introducing Dirac-Kahler twist. In addition to the BRST charge as a scalar counter part of twisted supercharge we find vector and tensor twisted supercharges. By introducing twisted chiral superfield we explicitly construct off-shell twisted N=4 SUSY invariant action. We can propose variety of supergauge invariant actions by introducing twisted vector superfield. We may, however, need to find further constraints to identify twisted N=4 super Yang-Mills action. We propose a superconnection formalism of twisted superspace where constraints play a crucial role. It turns out that N=4 superalgebra of Dirac-Kahler twist can be decomposed into N=2 sectors. We can then construct twisted N=2 super Yang-Mills actions by the superconnection formalism of twisted superspace in two and four dimensions.
Hidden Beauty in Twisted Viking Neck Rings
Olsen, Kasper
2010-01-01
Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that the vikings utilized a self-forming motif: The pattern arises from a twisting of the wires to a maximally rotated configuration. That is why the twist patterns in these arm and neck rings are beautiful, repetitive, and universal.
Darmani, N A; Reeves, S L
1996-11-01
Previously we have shown that cocaine attenuates the 5-HT2A receptor-mediated head-twitch response (HTR) in mice produced by the 5-HT2A/C direct agonist (+/-)-1 (2.5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). This inhibition appears to be due to cocaine-induced indirect stimulation of the inhibitory serotonergic 5-HT1A and noradrenergic alpha 2 receptors via the inhibition of reuptake of synaptic serotonin (5-HT) and norepinephrine (NE), respectively. In the present study, we investigated the effects of cocaine, its phenyltropane analogue WIN 35428, and the selective 5-HT (sertraline). NE (nisoxetine) and dopamine (DA) (GBR 12935) reuptake inhibitors on the 5-hydroxytryptophan (5-HTP)-induced HTR. We utilized two experimental protocols where cocaine or the cited drugs were administered either after (protocol 1) or prior (protocol 2) to 5-HTP injection. Cocaine in both protocols produced a dose-dependent enhancement in the 5-HTP-induced HTR (ED50 4.68 +/- 1.21 and 3.55 +/- 1.31, respectively). Sertraline was more potent (ED50 2.64 +/- 1.1 and 2.1 +/- 1.54, respectively) in enhancing the induced behavior and dose by dose produced greater (3 to 10 times) HTRs than cocaine. On the other hand, nisoxetine dose dependently and completely attenuated the induced behavior (ID50 3.33 +/- 1.32 and 1.72 +/- 1.34, respectively), whereas GBR 12935 only at high doses (ID50 15.34 +/- 1.52 and 11.91 +/- 1.3, respectively) decreased the induced response. The inability of cocaine to induce as many HTRs as sertraline appears to lie in its ability to also indirectly stimulate the inhibitory 5-HT1A and alpha 2 receptors because the stimulant caused greater enhancement in the 5-HTP-induced HTRs in the presence of their corresponding antagonists [S(-)-UH 301 and yohimbine, respectively]. WIN 35428 was more potent (ED50 2.87 +/- 1.3 and 1.79 +/- 1.1 for protocols 1 and 2, respectively) in stimulating the 5-HTP-induced HTR and produced a bell-shaped dose-response curve. The results
Broqua, P; Baudrie, V; Chaouloff, F
1992-06-01
Biochemical and behavioural experiments have indicated that the novel antidepressant tianeptine stimulates 5-hydroxytryptamine (5-HT) reuptake. The present study has explored the influence of acute tianeptine pretreatment upon corticosterone release and body weight loss following L-5-hydroxytryptophan (5-HTP) administration in conscious rats. Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand). Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats. However, combined administration of benserazide and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats. These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones.
Kirber, Helja
2014-01-01
Tutvustus: Sits, Eve Hele. Mooni talurahva tähtpäevik. [Tallinn] : Argo, c2011; Mooni metsauudistaja : tähelepanekuid ja lugusid metsaelust. [Tallinn] : Argo, c2012; Mooni Eestimaa raamat. [Tallinn] : Argo, c2013
Twisted spacetime in Einstein gravity
Zhang, Hongsheng
2016-01-01
We find a vacuum stationary twisted solution in four-dimensional Einstein gravity. Its frame dragging angular velocities are antisymmetric with respect to the equatorial plane. It possesses a symmetry of joint inversion of time and parity with respect to the equatorial plane. Its Arnowitt-Deser-Misner (ADM) mass and angular momentum are zero. It is curved but regular all over the manifold. Its Komar mass and Komar angular momentum are also zero. Its infinite red-shift surface coincides with its event horizon, since the event horizon does not rotate. Furthermore we extend this solution to the massive case, and find some similar properties. This solution is a stationary axisymmetric solution, but not Kerr. It explicitly proves that pure Einstein gravity permits different rotational mode other than Kerr. Our results demonstrate that the Einstein theory may have much more rich structures than what we ever imagine.
Twisting cracks in Bouligand structures.
Suksangpanya, Nobphadon; Yaraghi, Nicholas A; Kisailus, David; Zavattieri, Pablo
2017-06-10
The Bouligand structure, which is found in many biological materials, is a hierarchical architecture that features uniaxial fiber layers assembled periodically into a helicoidal pattern. Many studies have highlighted the high damage-resistant performance of natural and biomimetic Bouligand structures. One particular species that utilizes the Bouligand structure to achieve outstanding mechanical performance is the smashing Mantis Shrimp, Odontodactylus Scyllarus (or stomatopod). The mantis shrimp generates high speed, high acceleration blows using its raptorial appendage to defeat highly armored preys. The load-bearing part of this appendage, the dactyl club, contains an interior region [16] that consists of a Bouligand structure. This region is capable of developing a significant amount of nested twisting microcracks without exhibiting catastrophic failure. The development and propagation of these microcracks are a source of energy dissipation and stress relaxation that ultimately contributes to the remarkable damage tolerance properties of the dactyl club. We develop a theoretical model to provide additional insights into the local stress intensity factors at the crack front of twisting cracks formed within the Bouligand structure. Our results reveal that changes in the local fracture mode at the crack front leads to a reduction of the local strain energy release rate, hence, increasing the necessary applied energy release rate to propagate the crack, which is quantified by the local toughening factor. Ancillary 3D simulations of the asymptotic crack front field were carried out using a J-integral to validate the theoretical values of the energy release rate and the local stress intensity factors. Copyright © 2017 Elsevier Ltd. All rights reserved.
DYNAMICS OF STRONGLY TWISTED RELATIVISTIC MAGNETOSPHERES
Energy Technology Data Exchange (ETDEWEB)
Parfrey, Kyle [Astronomy Department, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Beloborodov, Andrei M.; Hui, Lam, E-mail: parfrey@astro.princeton.edu [Physics Department and Columbia Astrophysics Laboratory, Columbia University, 538 West 120th Street, New York, NY 10027 (United States)
2013-09-10
Magnetar magnetospheres are believed to be strongly twisted due to shearing of the stellar crust by internal magnetic stresses. We present time-dependent axisymmetric simulations showing in detail the evolution of relativistic force-free magnetospheres subjected to slow twisting through large angles. When the twist amplitude is small, the magnetosphere moves quasi-statically through a sequence of equilibria of increasing free energy. At some twist amplitude the magnetosphere becomes tearing-mode unstable to forming a resistive current sheet, initiating large-scale magnetic reconnection in which a significant fraction of the magnetic free energy can be dissipated. This ''critical'' twist angle is insensitive to the resistive length scale. Rapid shearing temporarily stabilizes the magnetosphere beyond the critical angle, allowing the magnetosphere of a rapidly differentially rotating star to store and dissipate more free energy. In addition to these effects, shearing the surface of a rotating star increases the spindown torque applied to the star. If shearing is much slower than rotation, the resulting spikes in spindown rate can occur on timescales anywhere from the long twisting timescale to the stellar spin period or shorter, depending both on the stellar shear distribution and the existing distribution of magnetospheric twists. A model in which energy is stored in the magnetosphere and released by a magnetospheric instability therefore predicts large changes in the measured spindown rate before soft gamma repeater giant flares.
Vieira-Coelho, M A; Soares-da-Silva, P
1997-05-01
The present study defined the kinetic characteristics of L-3,4-dihydroxyphenylalanine (L-dopa) and L-5-hydroxytryptophan (L-5-HTP) transport and their decarboxylation products, dopamine and 5-hydroxytryptamine (5-HT), respectively, in OK cells. The apical uptake of both L-dopa and 5-HTP was temperature dependent and stereoselective. Nonlinear analysis of the saturation curves revealed for L-dopa and L-5-HTP Michaelis constants of 13.8 and 29.1 microM, respectively, and maximal velocities of 21 and 29 nmol.mg protein-1.6 min-1, respectively, L-5-HTP inhibited the apical uptake of L-dopa with a half-maximal inhibitory constant of 29.1 microM. The accumulation of L-dopa and L-5-HTP from the basolateral cell border was dependent on the concentration used and saturable at nearly 50 microM. The accumulation of dopamine and 5-HT was found to be saturable only when the substrates were applied from the basolateral cell border. These results demonstrate that the L-dopa and L-5-HTP transporters in OK cells are located in both the apical and basolateral cell borders, whereas the uptake of dopamine and 5-HT is a saturable process only when the substrates are applied from the basolateral cell border.
Carlbom, Lina; Caballero-Corbalán, José; Granberg, Dan; Sörensen, Jens; Eriksson, Barbro; Ahlström, Håkan
2017-03-01
We wanted to explore if whole-body magnetic resonance imaging (MRI) including diffusion-weighted (DW) and liver-specific contrast agent-enhanced imaging could be valuable in lesion detection of neuroendocrine tumors (NET). [11C]-5-Hydroxytryptophan positron emission tomography/computed tomography (5-HTP PET/CT) was used for comparison. Twenty-one patients with NET were investigated with whole-body MRI, including DW imaging (DWI) and contrast-enhanced imaging of the liver, and whole-body 5-HTP PET/CT. Seven additional patients underwent upper abdomen MRI including DWI, liver-specific contrast agent-enhanced imaging, and 5-HTP PET/CT. There was a patient-based concordance of 61% and a lesion-based concordance of 53% between the modalities. MRI showed good concordance with PET in detecting bone metastases but was less sensitive in detecting metastases in mediastinal lymph nodes. MRI detected more liver metastases than 5-HTP PET/CT. Whole-body MRI with DWI did not detect all NET lesions found with whole-body 5-HTP PET/CT. Our findings indicate that MRI of the liver including liver-specific contrast agent-enhanced imaging and DWI could be a useful complement to whole-body 5-HTP PET/CT.
Novel Properties of Twisted-Photon Absorption
Afanasev, Andrei; Mukherjee, Asmita
2014-01-01
We discuss novel features of twisted-photon absorption both by atoms and by micro-particles. First, we extend the treatment of atomic photoexcitation by twisted photons to include atomic recoil, derive generalized quantum selection rules and consider phenomena of forbidden atomic transitions. Second, we analyze the radiation pressure from twisted-photon beams on micro- and nano-sized particles and observe that for particular conditions the pressure is negative in a small area near the beam axis. A central part of the beam therefore acts as a "tractor beam".
Twisted spectral geometry for the standard model
Martinetti, Pierre
2015-07-01
In noncommutative geometry, the spectral triple of a manifold does not generate bosonic fields, for fluctuations of the Dirac operator vanish. A Connes-Moscovici twist forces the commutative algebra to be multiplied by matrices. Keeping the space of spinors untouched, twisted-fluctuations then yield perturbations of the spin connection. Applied to the spectral triple of the Standard Model, a similar twist yields the scalar field needed to stabilize the vacuum and to make the computation of the Higgs mass compatible with its experimental value.
Directory of Open Access Journals (Sweden)
Juliana Bernardi Ogliari
2007-01-01
Full Text Available We used 125 microsatellite markers to genotype the maize (Zea mays L. near isogenic lines (NIL L30HtPHtPRtRt and L30htphtpRtRt and the L40htphtprtrt line which contrast regarding the presence of the recently described dominant HtP and the recessive rt genes that confer resistance to Exserohilum turcicum. Five microsatellite markers revealed polymorphisms between the NIL and were considered candidate linked markers for the HtP resistance gene. Linkage was confirmed by bulked segregant sample (BSS analysis of 32 susceptible and 34 resistant plants from a BC1F1 population derived from the cross (L30HtPHtPRtRt x L40htphtprtrt x L40htphtprtrt. The bnlg198 and dupssr25 markers, both located on maize chromosome 2L (bin 2.08, were polymorphic between bulks. Linkage distances were estimated based on co-segregation data of the 32 susceptible plants and indicated distances of 28.7 centimorgans (cM between HtP and bnlg198 and 23.5 cM between HtP and dupssr25. The same set of susceptible plants was also genotyped with markers polymorphic between L30HtPHtPRtRt and L40htphtprtrt in order to find markers linked to the rt gene. Marker bnlg197, from chromosome 3L (bin 3.06, was found linked to rt at a distance of 9.7 cM. This is the first report on the chromosomal locations of these newly described genes.
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.
Meng, Tian; Huang, Yanyu; Wang, Suzhen; Zhang, Hua; Dechow, Paul C; Wang, Xiaofang; Qin, Chunlin; Shi, Bing; D'Souza, Rena N; Lu, Yongbo
2015-12-04
Twist1 is a basic helix-loop-helix-containing transcription factor that is expressed in the dental mesenchyme during the early stages of tooth development. To better delineate its roles in tooth development, we generated Twist1 conditional knockout embryos (Twist2(Cre) (/+);Twist1(fl/fl)) by breeding Twist1 floxed mice (Twist1(fl/fl)) with Twist2-Cre recombinase knockin mice (Twist2(Cre) (/+)). The Twist2(Cre) (/+);Twist1(fl/fl) embryos formed smaller tooth germs and abnormal cusps during early tooth morphogenesis. Molecular and histological analyses showed that the developing molars of the Twist2(Cre) (/+);Twist1(fl/fl) embryos had reduced cell proliferation and expression of fibroblast growth factors 3, 4, 9, and 10 and FGF receptors 1 and 2 in the dental epithelium and mesenchyme. In addition, 3-week-old renal capsular transplants of embryonic day 18.5 Twist2(Cre) (/+);Twist1(fl/fl) molars showed malformed crowns and cusps with defective crown dentin and enamel. Immunohistochemical analyses revealed that the implanted mutant molars had defects in odontoblast differentiation and delayed ameloblast differentiation. Furthermore, in vitro ChIP assays demonstrated that Twist1 was able to bind to a specific region of the Fgf10 promoter. In conclusion, our findings suggest that Twist1 plays crucial roles in regulating tooth development and that it may exert its functions through the FGF signaling pathway. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Topological hypermultiplet on N=2 twisted superspace in four dimensions
Kato, J; Kato, Junji; Miyake, Akiko
2005-01-01
We propose a N=2 twisted superspace formalism with a central charge in four dimensions by introducing a Dirac-K\\"ahler twist. Using this formalism, we construct a twisted hypermultiplet action and find an explicit form of fermionic scalar, vector and tensor transformations. We construct a off-shell Donaldson-Witten theory coupled to the twisted hypermultiplet. We show that this action possesses N=4 twisted supersymmetry at on-shell level. It turns out that four-dimensional Dirac-K\\"ahler twist is equivalent to the Marcus's twist.
Transmission properties of cryogenic twisted pair filters
Energy Technology Data Exchange (ETDEWEB)
Song, Woon; Rehman, Mushtaq; Chong, Yonuk [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Ryu, Sangwan [Chonnam National University, Gwangju (Korea, Republic of)
2010-12-15
We fabricated a cryogenic low pass filter that consists of twisted pairs of manganin wires wrapped in copper tape and measured its transmission characteristics at frequencies up to 18 GHz. The dependence of the microwave transmission characteristics on the filter length was studied, which showed that a filter of length 1.0 m had a 70-dB attenuation at 1 GHz. We also studied the dependence of common- and differential-mode transmission on the number of twists per unit length and found that the number of twists per unit length affects differential-mode transmission but not common-mode transmission. Because the shielded twisted pair filter is more compact than a conventional copper powder filter, it can solve the space and thermal load issues when many cables are required for precision electronic transport experiments at low temperatures.
Mutations in the human TWIST gene.
Gripp, K W; Zackai, E H; Stolle, C A
2000-01-01
Saethre-Chotzen syndrome is a relatively common craniosynostosis disorder with autosomal dominant inheritance. Mutations in the TWIST gene have been identified in patients with Saethre-Chotzen syndrome. The TWIST gene product is a transcription factor with DNA binding and helix-loop-helix domains. Numerous missense and nonsense mutations cluster in the functional domains, without any apparent mutational hot spot. Two novel point mutations and one novel polymorphism are included in this review. Large deletions including the TWIST gene have been identified in some patients with learning disabilities or mental retardation, which are not typically part of the Saethre-Chotzen syndrome. Comprehensive studies in patients with the clinical diagnosis of Saethre-Chotzen syndrome have demonstrated a TWIST gene abnormality in about 80%, up to 37% of which may be large deletions [Johnson et al., 1998]. The gene deletions and numerous nonsense mutations are suggestive of haploinsufficiency as the disease-causing mechanism. No genotype phenotype correlation was apparent.
Observation of subluminal twisted light in vacuum
Bouchard, Frédéric; Mand, Harjaspreet; Boyd, Robert W; Karimi, Ebrahim
2015-01-01
Einstein's theory of relativity establishes the speed of light in vacuum, c, as a fundamental constant. However, the speed of light pulses can be altered significantly in dispersive materials. While significant control can be exerted over the speed of light in such media, no experimental demonstration of altered light speeds has hitherto been achieved in vacuum for ``twisted'' optical beams. We show that ``twisted'' light pulses exhibit subluminal velocities in vacuum, being slowed by 0.1\\% relative to c. This work does not challenge relativity theory, but experimentally supports a body of theoretical work on the counterintuitive vacuum group velocities of twisted pulses. These results are particularly important given recent interest in applications of twisted light to quantum information, communication and quantum key distribution.
Twisted Vector Bundles on Pointed Nodal Curves
Indian Academy of Sciences (India)
Ivan Kausz
2005-05-01
Motivated by the quest for a good compactification of the moduli space of -bundles on a nodal curve we establish a striking relationship between Abramovich’s and Vistoli’s twisted bundles and Gieseker vector bundles.
Gerbes and twisted orbifold quantum cohomology
Institute of Scientific and Technical Information of China (English)
2008-01-01
In this paper,we construct an orbifold quantum cohomology twisted by a flat gerbe. Then we compute these invariants in the case of a smooth manifold and a discrete torsion on a global quotient orbifold.
Deformed and twisted black holes with NUTs
Krtous, Pavel; Frolov, Valeri P; Kolar, Ivan
2015-01-01
We construct a new class of vacuum black hole solutions whose geometry is deformed and twisted by the presence of NUT charges. The solutions are obtained by `unspinning' the general Kerr-NUT-(A)dS spacetimes, effectively switching off some of their rotation parameters. The resulting geometry has a structure of warped space with the Kerr-like Lorentzian part warped to a Euclidean metric of deformed and/or twisted sphere, with the deformation and twist characterized by the `Euclidean NUT' parameters. In the absence of NUTs, the solution reduces to a well known Kerr-(A)dS black hole with several rotations switched off. New geometries inherit the original symmetry of the Kerr-NUT-(A)dS family, namely, they possess the full Killing tower of hidden and explicit symmetries. As expected, for vanishing NUT, twist, and deformation parameters, the symmetry is further enlarged.
Gerbes and twisted orbifold quantum cohomology
Institute of Scientific and Technical Information of China (English)
PAN JianZhong; RUAN YongBin; YIN XiaoQin
2008-01-01
In this paper, we construct an orbifold quantum cohomology twisted by a flat gerbe.Then we compute these invariants in the case of a smooth manifold and a discrete torsion on a global quotient orbifold.
Deformed and twisted black holes with NUTs
Krtouš, Pavel; Kubizňák, David; Frolov, Valeri P.; Kolář, Ivan
2016-06-01
We construct a new class of vacuum black hole solutions whose geometry is deformed and twisted by the presence of NUT charges. The solutions are obtained by ‘unspinning’ the general Kerr-NUT-(A)dS spacetimes, effectively switching off some of their rotation parameters. The resulting geometry has a structure of warped space with the Kerr-like Lorentzian part warped to a Euclidean metric of a deformed and/or twisted sphere, with the deformation and twist characterized by the ‘Euclidean NUT’ parameters. In the absence of NUTs, the solution reduces to a well known Kerr-(A)dS black hole with several rotations switched off. New geometries inherit the original symmetry of the Kerr-NUT-(A)dS family, namely, they possess the full Killing tower of hidden and explicit symmetries. As expected, for vanishing NUT, twist, and deformation parameters, the symmetry is further enlarged.
Genomic pathways modulated by Twist in breast cancer
Vesuna, Farhad; Bergman, Yehudit; Raman, Venu
2017-01-01
Background The basic helix-loop-helix transcription factor TWIST1 (Twist) is involved in embryonic cell lineage determination and mesodermal differentiation. There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis, but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear. Moreover, many of the genes and pathways dysregulated by Twist in cell lines and mouse models have not been validated against data obtaine...
DDalphaAMG for Twisted Mass Fermions
Bacchio, Simone; Finkenrath, Jacob; Frommer, Andreas; Kahl, Karsten; Rottmann, Matthias
2016-01-01
We present the Adaptive Aggregation-based Domain Decomposition Multigrid method extended to the twisted mass fermion discretization action. We show comparisons of results as a function of tuning the parameters that enter the twisted mass version of the DDalphaAMG library (https://github.com/sbacchio/DDalphaAMG). Moreover, we linked the DDalphaAMG library to the tmLQCD software package and give details on the performance of the multigrid solver during HMC simulations at the physical point.
Twisted Covariant Noncommutative Self-dual Gravity
Estrada-Jimenez, S; Obregón, O; Ramírez, C
2008-01-01
A twisted covariant formulation of noncommutative self-dual gravity is presented. The recent formulation introduced by J. Wess and coworkers for constructing twisted Yang-Mills fields is used. It is shown that the noncommutative torsion is solved at any order of the $\\theta$-expansion in terms of the tetrad and the extra fields of the theory. In the process the first order expansion in $\\theta$ for the Pleba\\'nski action is explicitly obtained.
OAM mode converter in twisted fibers
DEFF Research Database (Denmark)
Usuga Castaneda, Mario A.; Beltran-Mejia, Felipe; Cordeiro, Cristiano
2014-01-01
We analyze the case of an OAM mode converter based on a twisted fiber, through finite element simulations where we exploit an equivalence between geometric and material transformations. The obtained converter has potential applications in MDM. © 2014 OSA.......We analyze the case of an OAM mode converter based on a twisted fiber, through finite element simulations where we exploit an equivalence between geometric and material transformations. The obtained converter has potential applications in MDM. © 2014 OSA....
On Supermultiplet Twisting and Spin-Statistics
Hubsch, Tristan
2012-01-01
Twisting of off-shell supermultiplets in models with 1+1-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this type of twisting, if nontrivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets.
On Supermultiplet Twisting and Spin-Statistics
Hubsch, Tristan
2012-01-01
Twisting of off-shell supermultiplets in models with 1+1-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this off-shell supermultiplet twisting, if non-trivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets. This feature is shown to be ubiquitous in all...
The gradient flow in a twisted box
Energy Technology Data Exchange (ETDEWEB)
Ramos, Alberto [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC
2013-08-15
We study the perturbative behavior of the gradient flow in a twisted box. We apply this information to define a running coupling using the energy density of the flow field. We study the step-scaling function and the size of cutoff effects in SU(2) pure gauge theory. We conclude that the twisted gradient flow running coupling scheme is a valid strategy for step-scaling purposes due to the relatively mild cutoff effects and high precision.
Twisted Boundary Conditions in Lattice Simulations
Sachrajda, Christopher T C
2004-01-01
By imposing twisted boundary conditions on quark fields it is possible to access components of momenta other than integer multiples of 2pi/L on a lattice with spatial volume L^3. We use Chiral Perturbation Theory to study finite-volume effects with twisted boundary conditions for quantities without final-state interactions, such as meson masses, decay constants and semileptonic form factors, and confirm that they remain exponentially small with the volume. We show that this is also the case for "partially twisted" boundary conditions, in which (some of) the valence quarks satisfy twisted boundary conditions but the sea quarks satisfy periodic boundary conditions. This observation implies that it is not necessary to generate new gluon configurations for every choice of the twist angle, making the method much more practicable. For K->pipi decays we show that the breaking of isospin symmetry by the twisted boundary conditions implies that the amplitudes cannot be determined in general (on this point we disagree ...
An inspiring star——in Oliver Twist
Institute of Scientific and Technical Information of China (English)
胡斯嘉
2009-01-01
@@ In 1838, the second long novel of Charles Dickens Oliver Twist was published and this soul stirring story which delineates a valiant boy and his constant struggle with vicious powers eventually stood out and made a deep impression on many readers' mind. Without too many sophisticate plots and flowery languages, this novel is proved to be one of the most successful books in English literature of 19th century. Especially in the aspect of revealing the reality, the realistic writer Dickens authentically presented a miniature of English society to readers.
Ahlenius, S; Larsson, K
1998-06-01
The administration of the 5-hydroxytryptamine (5-HT) precursor 5-hydroxytryptophan (5-HTP) (25 mg/kg i.p.), in combination with an inhibitor of peripheral 5-HTP decarboxylase, produced a dose-dependent increase in the ejaculation latency of male rats, and this effect was enhanced by additional treatment with the 5-HT1 receptor antagonist (-)-pindolol (2 mg/kg s.c.). The 5-HT2A/C receptor agonist (+/-) 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (0.125-0.5 mg/kg s.c.) did not by itself affect male ejaculatory behavior, but additional treatment with (-)-pindolol (2 mg/kg s.c.) produced a dose-dependent decrease in number of ejaculating animals. The increased ejaculation latency produced by 5-HTP was fully antagonized by treatment with the 5-HT1B receptor antagonist isamoltane (4 mg/kg s.c.), but not by ritanserin (2 mg/kg s.c.) treatment. The selective 5-HT1A receptor antagonist WAY-100635 (0.15 mg/kg s.c.) enhanced the inhibitory actions of 5-HTP on the male rat ejaculatory behavior, and this dose of WAY-100635 fully antagonized 8-OH-DPAT-induced facilitation (0.25 mg/kg s.c.) of the ejaculatory behavior. WAY-100635 (0.04-0.60 mg/kg s.c.) did not, by itself, significantly affect male rat sexual behavior. Taken together, the results suggest an inhibitory role for postsynaptic 5-HT1B receptors in the effects produced by 5-HTP on male rat ejaculatory behavior. Furthermore, 5-HTP-induced inhibition of male rat ejaculatory behavior is partially controlled by stimulation of inhibitory 5-HT1A autoreceptors, since the effects of 5-HTP were accentuated by treatment with (-)-pindolol, as well as by the more selective 5-HT1A receptor antagonist WAY-100635.
Soft tissue twisting injuries of the knee
Energy Technology Data Exchange (ETDEWEB)
Magee, T.; Shapiro, M. [Neuroimaging Inst., Melbourne, FL (United States)
2001-08-01
Twisting injuries occur as a result of differential motion of different tissue types in injuries with some rotational force. These injuries are well described in brain injuries but, to our knowledge, have not been described in the musculoskeletal literature. We correlated the clinical examination and MR findings of 20 patients with twisting injuries of the soft tissues around the knee. Design and patients: We prospectively followed the clinical courses of 20 patients with knee injuries who had clinical histories and MR findings to suggest twisting injuries of the subcutaneous tissues. Patients with associated internal derangement of the knee (i.e., meniscal tears, ligamentous or bone injuries) were excluded from this study. MR findings to suggest twisting injuries included linear areas of abnormal dark signal on T1-weighted sequences and abnormal bright signal on T2-weighted or short tau inversion recovery (STIR) sequences and/or signal to suggest hemorrhage within the subcutaneous tissues. These MR criteria were adapted from those established for indirect musculotendinous junction injuries. Results: All 20 patients presented with considerable pain that suggested internal derangement on physical examination by the referring orthopedic surgeons. All presented with injuries associated with rotational force. The patients were placed on a course of protected weight-bearing of the affected extremity for 4 weeks. All patients had pain relief by clinical examination after this period of protected weight-bearing. Twisting injuries of the soft tissues can result in considerable pain that can be confused with internal derangement of the knee on physical examination. Soft tissue twisting injuries need to be recognized on MR examinations as they may be the cause of the patient's pain despite no MR evidence of internal derangement of the knee. The demonstration of soft tissue twisting injuries in a patient with severe knee pain but no documented internal derangement on MR
Indian Academy of Sciences (India)
Rambir Bhadouriya; Amit Agrawal; S V Prabhu
2015-04-01
The problem of fluid flow and heat transfer was studied for flow inside twisted duct of square cross-section. Three-dimensional numerical solutions were obtained for steady fully developed laminar flow and for uniform wall heat flux boundary conditions using commercially available software. Reynolds number range considered was 100-3000. Twist ratio used are 2.5, 5, 10 and 20. Fluids considered are in Prandtl number range of 0.7-20. Product of friction factor and Reynolds number is found to be a function of Reynolds number and maximum values are observed for a twist ratio of 2.5 and Reynolds number of 3000. Maximum Nusselt number is observed for the same values along with Prandtl number of 20. Correlations for friction factor and Nusselt number are developed involving swirl parameter. Local distribution of friction factor ratio and Nusselt number across a cross-section is presented. Based on constant pumping power criteria, enhancement factor is defined to compare twisted ducts with straight ducts. Selection of twisted square duct is presented in terms of enhancement factor. It is found that twisted duct performs well in the laminar region for range of parameters studied. Heat transfer enhancement for Reynolds number of 3000 and Prandtl number of 0.7 for twist ratio of 2.5, 5, 10, and 20 is 20%, 17.8%, 16.1% and 13.7%, respectively. The results are significant because it will contribute to development of energy efficient compact size heat exchangers.
Sun, Hong-Lei; Zheng, Ji-Wang; Wang, Keng; Liu, Rui-Ke; Liang, Jian-Hui
2003-01-31
Tramadol, an atypical opioid analgesic, stimulates both opiatergic and serotonergic systems. Here we have investigated the effect of tramadol in mice on 5-hydroxyptrytophan (5-HTP)-induced head twitch response (HTR), which is an animal model for the activation of the CNS 5-HT(2A) receptors in mice. Tramadol attenuated 5-HTP-induced HTR in a dose-dependent manner as morphine. Furthermore, the nonselective opioid receptor antagonists, naloxone and diprenorphine (M5050), reversed the effect of tramadol on 5-HTP-induced HTR dose-dependently. Interestingly, in contrast to the selective delta opioid receptor antagonist NTI, beta-FNA, a selective mu receptor antagonist, and nor-BNI, a selective kappa opioid receptor antagonist, antagonized the attenuation of 5-HTP-induced HTR by tramadol. In conclusion, administration of tramadol systemically inhibits 5-HTP-induced HTR in mice by activating opiatergic system in the CNS. Our findings show that mu and kappa opioid receptors, but not delta opioid receptor, play an important role in the regulation of serotonergic function in the CNS.
Baumann, Michael H; Williams, Zakia; Zolkowska, Dorota; Rothman, Richard B
2011-04-01
Evidence suggests that increases in synaptic serotonin (5-HT) can reduce the stimulant properties of amphetamine-type drugs. Here we tested the hypothesis that administration of the 5-HT precursor 5-hydroxy-l-tryptophan (5-HTP), along with the peripheral decarboxylase inhibitor benserazide, would decrease locomotor effects of (+)-amphetamine. Drug treatments were administered to conscious male rats undergoing in vivo microdialysis in nucleus accumbens. During dialysis sampling, rats were housed in chambers equipped with photobeams to detect forward locomotion (i.e., ambulation) and repetitive movements (i.e., stereotypy). Extracellular concentrations of dopamine (DA) and 5-HT were measured by high-pressure liquid chromatography with electrochemical detection. 5-HTP (10 & 30 mg/kg, i.p.) plus benserazide (30 mg/kg, i.p.) caused dose-related increases in 5-HT but failed to alter other parameters. (+)-Amphetamine (0.3 & 1.0 mg/kg, i.p.) produced dose-related increases in DA, ambulation and stereotypy. Combined administration of 5-HTP and (+)-amphetamine evoked large elevations in extracellular DA and 5-HT, but caused significantly less ambulation than (+)-amphetamine alone (~50% reduction). Our results confirm that 5-HTP can decrease hyperactivity produced by (+)-amphetamine, even in the presence of elevations in dialysate DA. The data suggest that 5-HTP and (+)-amphetamine may be useful to broadly enhance monoamine function in the clinical setting, while reducing undesirable effects of (+)-amphetamine. Published by Elsevier Ireland Ltd.
Miyakoshi, N; Tanaka, M; Shindo, H
1980-12-01
The distribution and metabolism of L-DOPA-14C and L-5-HTP-14C in the cat brain were examined by means of autoradiography and chromatography. The results revealed that an appreciable amount of radioactivity in the gray matter, but not the white, and that the localization of radioactivity of L-DOPA and L-5-HTP significantly differed. After L-DOPA-14C administration, a high accumulation was found in the caudate nucleus, putamen and pallidum. With L-5-HTP-14C administration, high radioactivity was observed in the hypothalamus, raphe nucleus, substantia nigra, inferior olivalis and caudate nucleus. An analysis of the main metabolites of both amino acids in various regions of the brain was also made. When L-DOPA was given, a high concentration of dopamine was detected in the caudate nucleus, followed by the hypothalamus. In the case of L-5-HTP, a high concentration of serotonin was detected in the hypothalamus and the medulla oblongata. These results suggest that amines derived from exogenously administered L-DOPA and L-5-HTP accumulate in the brain regions known as the corresponding amine rich regions, under physiological conditions.
Arnt, J; Hyttel, J; Larsen, J J
1984-11-01
Combination of the 5-HT-uptake inhibitor, citalopram, with 1-5-HTP induced a characteristic head shake syndrome in rats. This was blocked by a range of 5-HT antagonists, including the selective 5-HT2 antagonists, ketanserin and pirenperone and was also blocked by the alpha 1-adrenoceptor antagonists, prazosin and WB 4101, and the alpha 2-adrenoceptor agonist, clonidine. 1-5-HTP-antagonistic effect was also recorded for 26 neuroleptic drugs. Their inhibitory potencies showed close correlation to 5-HT2-receptor affinity in vitro and, slightly weaker, to alpha 1-adrenoceptor affinity. In contrast, no correlation to dopamine D-2 receptor affinity was found, indicating that the cataleptogenic and motility-inhibitory properties of neuroleptics did not unspecifically influence 1-5-HTP-induced head shakes. These were not influenced by a histaminic antagonist, muscarinic antagonist or alpha 2-adrenoceptor antagonist, but were inhibited by beta-adrenoceptor blockers, GABA agonists, a benzodiazepine and morphine. The results indicate that 1-5-HTP-induced head shakes are most sensitive to 5-HT2 antagonists, but that the syndrome is influenced by other neuronal systems. Since 5-HT2 affinity and alpha 1-adrenoceptor affinity of many compounds is found concomitantly, caution is needed to evaluate the relative importance of these properties for 1-5-HTP antagonism.
Baumann, Michael H.; Williams, Zakia; Zolkowska, Dorota; Rothman, Richard B.
2010-01-01
Background Evidence suggests that increases in synaptic serotonin (5-HT) can reduce the stimulant properties of amphetamine-type drugs. Here we tested the hypothesis that administration of the 5-HT precursor 5-hydroxy-L-tryptophan (5-HTP), along with the peripheral decarboxylase inhibitor benserazide, would decrease locomotor effects of (+)-amphetamine. Methods Drug treatments were administered to conscious male rats undergoing in vivo microdialysis in nucleus accumbens. During dialysis sampling, rats were housed in chambers equipped with photobeams to detect forward locomotion (i.e., ambulation) and repetitive movements (i.e., stereotypy). Extracellular concentrations of dopamine (DA) and 5-HT were measured by high-pressure liquid chromatography with electrochemical detection. Results 5-HTP (10 & 30 mg/kg, i.p.) plus benserazide (30 mg/kg, i.p.) caused dose-related increases in 5-HT but failed to alter other parameters. (+)-Amphetamine (0.3 & 1.0 mg/kg, i.p.) produced dose-related increases in DA, ambulation and stereotypy. Combined administration of 5-HTP and (+)-amphetamine evoked large elevations in extracellular DA and 5-HT, but caused significantly less ambulation than (+)-amphetamine alone (~50% reduction). Conclusions Our results confirm that 5-HTP can decrease hyperactivity produced by (+)-amphetamine, even in the presence of elevations in dialysate DA. The data suggest that 5-HTP and (+)-amphetamine may be useful to broadly enhance monoamine function in the clinical setting, while reducing undesirable effects of (+)-amphetamine. PMID:21071157
Noncommutative geometry in string and twisted Hopf algebra of diffeomorphism
Watamura, Satoshi
2011-09-01
We discuss the Hopf algebra structure in string theory and present the twist quantization as a unified formulation of the world sheet quantization of the string and the symmetry of the target spacetime. Applying it to the case with a nonzero B-field background, we explain a method to decompose the twist into two successive twists. There are two different possibilities of decomposition: The first is a natural decomposition from the viewpoint of the twist quantization, leading to a new type of twisted Poincaré symmetry. The second decomposition reveals the relation of our formulation to the twisted Poincaré symmetry on the Moyal type noncommutative space.
Twisted electron-acoustic waves in plasmas
Aman-ur-Rehman, Ali, S.; Khan, S. A.; Shahzad, K.
2016-08-01
In the paraxial limit, a twisted electron-acoustic (EA) wave is studied in a collisionless unmagnetized plasma, whose constituents are the dynamical cold electrons and Boltzmannian hot electrons in the background of static positive ions. The analytical and numerical solutions of the plasma kinetic equation suggest that EA waves with finite amount of orbital angular momentum exhibit a twist in its behavior. The twisted wave particle resonance is also taken into consideration that has been appeared through the effective wave number qeff accounting for Laguerre-Gaussian mode profiles attributed to helical phase structures. Consequently, the dispersion relation and the damping rate of the EA waves are significantly modified with the twisted parameter η, and for η → ∞, the results coincide with the straight propagating plane EA waves. Numerically, new features of twisted EA waves are identified by considering various regimes of wavelength and the results might be useful for transport and trapping of plasma particles in a two-electron component plasma.
Twisted X-rays: incoming waveforms yielding discrete diffraction patterns for helical structures
Friesecke, Gero; Jüstel, Dominik
2015-01-01
Conventional X-ray methods use incoming plane waves and result in discrete diffraction patterns when scattered at crystals. Here we find, by a systematic method, incoming waveforms which exhibit discrete diffraction patterns when scattered at helical structures. As examples we present simulated diffraction patterns of carbon nanotubes and tobacco mosaic virus. The new incoming waveforms, which we call twisted waves due to their geometric shape, are found theoretically as closed-form solutions to Maxwell's equations. The theory of the ensuing diffraction patterns is developed in detail. A twisted analogue of the Von Laue condition is seen to hold, with the peak locations encoding the symmetry and the helix parameters, and the peak intensities indicating the electronic structure in the unit cell. If suitable twisted X-ray sources can in the future be realized experimentally, it appears from our mathematical results that they will provide a powerful tool for directly determining the detailed atomic structure of ...
Exotic twisted equivariant cohomology of loop spaces,twisted Bismut-Chern character and T-duality
Han, Fei
2014-01-01
We define completed periodic {\\em exotic twisted $\\mathbb{T}$-equivariant cohomology} for loop spaces of smooth manifolds. We then show that the twisted Bismut-Chern character, defined on the twisted K-theory of the smooth manifold, twisted by a gerbe with connection, takes values in the completed periodic exotic twisted $\\mathbb{T}$-equivariant cohomology of the loop space of the smooth manifold. We establish a localisation theorem for the completed periodic exotic twisted $\\mathbb{T}$-equivariant cohomology for loop spaces and apply it to establish T-duality in a background flux in type II String Theory from a loop space perspective.
Unraveling cellulose microfibrils: a twisted tale.
Hadden, Jodi A; French, Alfred D; Woods, Robert J
2013-10-01
Molecular dynamics (MD) simulations of cellulose microfibrils are pertinent to the paper, textile, and biofuels industries for their unique capacity to characterize dynamic behavior and atomic-level interactions with solvent molecules and cellulase enzymes. While high-resolution crystallographic data have established a solid basis for computational analysis of cellulose, previous work has demonstrated a tendency for modeled microfibrils to diverge from the linear experimental structure and adopt a twisted conformation. Here, we investigate the dependence of this twisting behavior on computational approximations and establish the theoretical basis for its occurrence. We examine the role of solvent, the effect of nonbonded force field parameters [partial charges and van der Waals (vdW) contributions], and the use of explicitly modeled oxygen lone pairs in both the solute and solvent. Findings suggest that microfibril twisting is favored by vdW interactions, and counteracted by both intrachain hydrogen bonds and solvent effects at the microfibril surface.
Analysis of gun barrel rifling twist
Sun, Jia; Chen, Guangsong; Qian, Linfang; Liu, Taisu
2017-05-01
Aiming at the problem of gun barrel rifling twist, the constraint relation between rifling and projectile is investigated. The constraint model of rifling and projectile is established and the geometric relation between the twist and the motion of projectile is analyzed. Based on the constraint model, according to the rotating band that is fired, the stress and the motion law of the rotating band in bore are analyzed. The effects to rotating band (double rotating band or wide driving band) caused by different rifling (rib rifling, increasing rifling and combined rifling) are also investigated. The model is demonstrated by several examples. The results of numerical examples and the constraint mode show that the uncertainty factors will be brought in the increasing rifling and combined rifling during the projectile move in the bore. According to the amplitude and the strength of the twist acting on rotating band, the steady property of rotational motion of the projectile, the rib rifling is a better choose.
Blind analysis results of the TWIST experiment
Hillairet, A; Bueno, J F; Davydov, Y I; Depommier, P; Faszer, W; Fujiwara, M C; Gagliardi, C A; Gaponenko, A; Grossheim, A; Gill, D R; Gumplinger, P; Hasinoff, M D; Henderson, R S; Hu, J; Koetke, D D; MacDonald, R P; Marshall, G M; Mathie, E W; Mischke, R E; Olchanski, K; Olin, A; Openshaw, R; Poutissou, J -M; Poutissou, R; Selivanov, V; Sheffer, G; Shin, B; Stanislaus, T D S; Tacik, R; Tribble, R E
2010-01-01
The TRIUMF Weak Interaction Symmetry Test (TWIST) experiment was designed to test the standard model at high precision in the purely leptonic decay of polarized muons. A general four-fermion interaction model is used to describe the muon decay. TWIST measures three of the four muon decay parameters of this model, $\\rho$, $\\delta$ and $P_{\\mu}^{\\pi} \\xi$, from the shape of the momentum-angle spectrum. The results of this model independent approach are compared to the standard model predictions and used to constrain new physics. Our collaboration has finalized the blind analysis of the final experimental data taken in 2006 and 2007. This analysis mostly reached our goal of a precision of an order of magnitude improvement over the pre-TWIST measurements.
Helicoids, wrinkles, and loops in twisted ribbons.
Chopin, Julien; Kudrolli, Arshad
2013-10-25
We investigate the instabilities of a flat elastic ribbon subject to twist under tension and develop an integrated phase diagram of the observed shapes and transitions. We find that the primary buckling mode switches from being localized longitudinally along the length of the ribbon to transverse above a triple point characterized by a crossover tension that scales with ribbon elasticity and aspect ratio. Far from threshold, the longitudinally buckled ribbon evolves continuously into a self-creased helicoid with focusing of the curvature along the triangular edges. Further twist causes an anomalous transition to loops compared with rods due to the self-rigidity induced by the creases. When the ribbon is twisted under high tension, transverse wrinkles are observed due to the development of compressive stresses with higher harmonics for greater width-to-length ratios. Our results can be used to develop functional structures using a wide range of elastic materials and length scales.
Dynamical Twisted Mass Fermions with Light Quarks
Boucaud, P; Farchioni, F; Frezzotti, R; Giménez, V; Herdoiza, G; Jansen, K; Lubicz, V; Martinelli, G; McNeile, C; Michael, C; Montvay, I; Palao, D; Papinutto, Mauro; Pickavance, J; Rossi, G C; Scorzato, L; Shindler, A; Simula, S; Urbach, C; Wenger, U; Boucaud, Ph.
2007-01-01
We present results of dynamical simulations with 2 flavours of degenerate Wilson twisted mass quarks at maximal twist in the range of pseudo scalar masses from 300 to 550 MeV. The simulations are performed at one value of the lattice spacing a \\lesssim 0.1 fm. In order to have O(a) improvement and aiming at small residual cutoff effects, the theory is tuned to maximal twist by requiring the vanishing of the untwisted quark mass. Precise results for the pseudo scalar decay constant and the pseudo scalar mass are confronted with chiral perturbation theory predictions and the low energy constants F, \\bar{l}_3 and \\bar{l}_4 are evaluated with small statistical errors.
Matrix theory compactifications on twisted tori
Chatzistavrakidis, Athanasios
2012-01-01
We study compactifications of Matrix theory on twisted tori and non-commutative versions of them. As a first step, we review the construction of multidimensional twisted tori realized as nilmanifolds based on certain nilpotent Lie algebras. Subsequently, matrix compactifications on tori are revisited and the previously known results are supplemented with a background of a non-commutative torus with non-constant non-commutativity and an underlying non-associative structure on its phase space. Next we turn our attention to 3- and 6-dimensional twisted tori and we describe consistent backgrounds of Matrix theory on them by stating and solving the conditions which describe the corresponding compactification. Both commutative and non-commutative solutions are found in all cases. Finally, we comment on the correspondence among the obtained solutions and flux compactifications of 11-dimensional supergravity, as well as on relations among themselves, such as Seiberg-Witten maps and T-duality.
On reweighting for twisted boundary conditions
Bussone, Andrea; Hansen, Martin; Pica, Claudio
2016-01-01
We consider the possibility of using reweighting techniques in order to correct for the breaking of unitarity when twisted boundary conditions are imposed on valence fermions in simulations of lattice gauge theories. We start by studying the properties of reweighting factors and their variances at tree-level. That leads us to the introduction of a factorization for the fermionic reweighting determinant. In the numerical, stochastic, implementation of the method, we find that the effect of reweighting is negligible in the case of large volumes but it is sizeable when the volumes are small and the twisting angles are large. More importantly, we find that for un-improved Wilson fermions, and in small volumes, the dependence of the critical quark mass on the twisting angle is quite pronounced and results in large violations of the continuum dispersion relation.
Reaction of O(/sup 3/P) atoms with ethane: An HTP kinetics study from 300 to 1270 K
Energy Technology Data Exchange (ETDEWEB)
Mahmud, K.; Marshall, P.; Fontijn, A.
1988-02-15
Rate coefficients for the O+C/sub 2/H/sub 6/ reaction have been measured using the high-temperature photochemistry (HTP) technique. Strong non-Arrhenius behavior is observed. The data are well fitted by the empirical expression k(T) = 1.9 x 10/sup -31/ T/sup 6.5/ exp(-138 K/T) cm/sup 3/ molecule/sup -1/ s/sup -1/. Confidence limits are discussed in the text. The results are consistent with calculations based on transition state theory and tunneling through an Eckart barrier.
Emmers, R; Tamir, H; Wilchek, M
1987-06-01
The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ventralis posterolateralis of the thalamus. With tungsten microelectrodes, individual nociceptive neurons in the nucleus were identified by the sequence of spikes emitted in response to single-pulse stimulation of the sciatic nerve. In addition to the usual short-latency spikes, a nociceptive neuron fired late spikes at regular intervals within 500 ms following each stimulus. When the spikes were accumulated in poststimulus time histograms, the short-latency spikes compiled an intensity-related (I) peak. The late spikes formed modality-related (M) peaks with spacing characteristic of nociception. Intracarotid infusion of 5-HTP-DP-hex (1 mg/kg) elevated the delayed portion of the I peak and the first M peak. This effect was followed in 25 min by suppression of all M peaks. The control record could be reinstated at any time by 5-hydroxytryptophan (3.5 mg/kg), or by natural recovery in 2.5 h. Responses evoked from a thalamic nociceptive neuron by single-pulse stimulation of the spinothalamic tract were modified by 5-HTP-DP-hex in a similar manner, except that no elevation of the activity peaks was observed. As shown previously, elevation of the delayed I peak and M1 indicated an increased input of A-delta and C fibers, respectively. The increased input lowers the response threshold and may represent hyperalgesia. Suppression of the M peaks may result from altered function of the positive feedback loop in the nociceptive system at the thalamic level, and may represent analgesia. Naloxone, methysergide, as well as ketanserin had no significant effect on the response histograms. These findings suggested that 5-HTP-DP-hex, a known serotonin receptor antagonist
The reaction of O(3P) atoms with ethane: An HTP kinetics study from 300 to 1270 K
Mahmud, Khaled; Marshall, Paul; Fontijn, Arthur
1988-02-01
Rate coefficients for the O+C2H6 reaction have been measured using the high-temperature photochemistry (HTP) technique. Strong non-Arrhenius behavior is observed. The data are well fitted by the empirical expression k(T)=1.9×10-31 T6.5 exp(-138 K/T) cm3 molecule-1 s-1. Confidence limits are discussed in the text. The results are consistent with calculations based on transition state theory and tunneling through an Eckart barrier.
Estructuración de los milestones para la gestión del proyecto HTP BOX C919
Alemán Mendibe, Albaro Xabier
2015-01-01
El objetivo de este proyecto fin de carrera es intentar mejorar el actual sistema de seguimiento del proyecto HTP que realiza el taladrado y el remachado de los elevadores del avión comercial C919 y definir la documentación oficial (entregables al cliente). Identificar cual es la información necesaria para controlar el seguimiento del mismo en cada una de las fases en la que está estructurado aumentará sensiblemente la capacidad organizativa del mismo. En la actualidad existen únicamente algu...
Suppression of rpoH (htpR) mutations of Escherichia coli: heat shock response in suhA revertants.
Tobe, T; Kusukawa, N; Yura, T
1987-01-01
Temperature-resistant pseudorevertants were isolated from rpoH (htpR) mutants of Escherichia coli K-12 that cannot grow at a high temperature owing to a deficiency in sigma 32 required for the induction of heat shock proteins. Among them was a class of revertants carrying a suppressor mutation, designated suhA, that suppressed all the nonsense and missense rpoH mutations tested. suhA is located at 77 min, about 1 min away from rpoH, on the genetic map. In contrast to the rpoH mutants, the suh...
Maes, M; Calabrese, J; Jayathilake, K; Meltzer, H Y
1997-07-04
The mechanisms underlying the acute and prophylactic antimanic properties of valproate have remained elusive. There are some reports that treatment with valproic acid may increase brain serotonergic neurotransmission in the rodent. This study was carried out in order to investigate the effects of subchronic therapy with valproate on central serotonin metabolism in manic patients. Toward this end, the authors examined plasma cortisol responses to 200 mg (orally) L-5-hydroxy-tryptophan (L-5-HTP) in 10 manic patients both before and after subchronic treatment with valproate. Administration of L-5-HTP resulted in significantly increased cortisol responses both before and after treatment with valproate. The L-5-HTP-induced cortisol responses were significantly higher after treatment with valproate than before treatment. It is suggested that valproate may increase central serotonergic neurotransmission and that this stimulation may play a role in the antimanic effects of valproate.
Local index formula and twisted spectral triples
Moscovici, Henri
2009-01-01
We prove a local index formula for a class of twisted spectral triples of type III modeled on the transverse geometry of conformal foliations with locally constant transverse conformal factor. Compared with the earlier proof of the untwisted case, the novel aspect resides in the fact that the twisted analogues of the JLO entire cocycle and of its retraction are no longer cocycles in their respective Connes bicomplexes. We show however that the passage to the infinite temperature limit, respectively the integration along the full temperature range against the Haar measure of the positive half-line, has the remarkable effect of curing in both cases the deviations from the cocycle identity.
On Supermultiplet Twisting and Spin-Statistics
Hübsch, T.
2013-10-01
Twisting of off-shell supermultiplets in models with (1+1)-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this off-shell supermultiplet twisting, if nontrivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets. This feature is shown to be ubiquitous in all fully off-shell supersymmetric models with (BV/BRST-treated) constraints.
Multi-twist optical Mobius strips
Freund, Isaac
2009-01-01
Circularly polarized Gauss-Laguerre GL(0,0) and GL(0,1) laser beams that cross at their waists at a small angle are shown to generate a quasi-paraxial field that contains an axial line of circular polarization, a C line, surrounded by polarization ellipses whose major and minor axes generate multi-twist Mobius strips with twist numbers that increase with distance from the C point. These Mobius strips are interpreted in terms of Berry's phase for parallel transport of the ellipse axes around the C point.
Effects Of Twist On Ceramic Threads
Sawko, Paul M.; Tran, Huy Kim
1989-01-01
Report describes study of effects of yarn twist and other manufacturing parameters on strength of ceramic sewing threads. Three types of thread considered; silica, aluminoborosilicate (ABS) with 14 percent boria, and ABS with 2 percent boria. For silica thread, best twist found 300 turns per meter. Produced highest break strength at temperatures up to about 540 degree C. Overall strengths of both ABS threads higher than silica thread. Threads used to stitch insulating blankets for reusable spacraft; must resist high temperatures and high aerodynamic loads of reentry into atmosphere of Earth.
Spectral flows and twisted topological theories
Gato-Rivera, Beatriz; Gato-Rivera, Beatriz; Rosado, Jose Ignacio
1995-01-01
We analyze the action of the spectral flows on N=2 twisted topological theories. We show that they provide a useful mapping between the two twisted topological theories associated to a given N=2 superconformal theory. This mapping can also be viewed as a topological algebra automorphism. In particular null vectors are mapped into null vectors, considerably simplifying their computation. We give the level 2 results. Finally we discuss the spectral flow mapping in the case of the DDK and KM realizations of the topological algebra.
A non-commuting twist in the partition function
Govindarajan, Suresh
2012-01-01
We compute a twisted index for an orbifold theory when the twist generating group does not commute with the orbifold group. The twisted index requires the theory to be defined on moduli spaces that are compatible with the twist. This is carried out for CHL models at special points in the moduli space where they admit dihedral symmetries. The commutator subgroup of the dihedral groups are cyclic groups that are used to construct the CHL orbifolds. The residual reflection symmetry is chosen to act as a `twist' on the partition function. The reflection symmetries do not commute with the orbifolding group and hence we refer to this as a non-commuting twist. We count the degeneracy of half-BPS states using the twisted partition function and find that the contribution comes mainly from the untwisted sector. We show that the generating function for these twisted BPS states are related to the Mathieu group M_{24}.
Kantarelis, E; Donaj, P; Yang, W; Zabaniotou, A
2009-08-15
In the present study the energetic valorization of electric cable shredder residues (mixed plastics) has been investigated. Thermochemical conversion by means of High-Temperature Steam Gasification (HTSG) and High-Temperature Pyrolysis (HTP) was studied. The effects of temperature and reaction time--process parameters--were investigated. Comparison of the results showed that HTSG seems a more suitable process in terms of produced syngas quality (64%, v/v and 13MJ/Nm(3)) than HTP because of higher H(2) yield and lower tar content.
Energy Technology Data Exchange (ETDEWEB)
Kantarelis, E. [Department of Chemical Engineering, Aristotle University of Thessaloniki, Un.Box 455, University Campus, GR54124 Thessaloniki (Greece); Donaj, P.; Yang, W. [Royal Institute of Technology (KTH), School of Industrial Engineering and Management, Department of Materials Science and Engineering, Division of Energy and Furnace Technology, SE100 44 Stockholm (Sweden); Zabaniotou, A., E-mail: sonia@cheng.auth.gr [Department of Chemical Engineering, Aristotle University of Thessaloniki, Un.Box 455, University Campus, GR54124 Thessaloniki (Greece)
2009-08-15
In the present study the energetic valorization of electric cable shredder residues (mixed plastics) has been investigated. Thermochemical conversion by means of High-Temperature Steam Gasification (HTSG) and High-Temperature Pyrolysis (HTP) was studied. The effects of temperature and reaction time - process parameters - were investigated. Comparison of the results showed that HTSG seems a more suitable process in terms of produced syngas quality (64%, v/v and 13 MJ/Nm{sup 3}) than HTP because of higher H{sub 2} yield and lower tar content.
On Twisting Real Spectral Triples by Algebra Automorphisms
Landi, Giovanni; Martinetti, Pierre
2016-11-01
We systematically investigate ways to twist a real spectral triple via an algebra automorphism and in particular, we naturally define a twisted partner for any real graded spectral triple. Among other things, we investigate consequences of the twisting on the fluctuations of the metric and possible applications to the spectral approach to the Standard Model of particle physics.
On Twisting Real Spectral Triples by Algebra Automorphisms
Landi, Giovanni; Martinetti, Pierre
2016-08-01
We systematically investigate ways to twist a real spectral triple via an algebra automorphism and in particular, we naturally define a twisted partner for any real graded spectral triple. Among other things, we investigate consequences of the twisting on the fluctuations of the metric and possible applications to the spectral approach to the Standard Model of particle physics.
Twisting singular solutions of Bethe's equations
Nepomechie, Rafael I
2014-01-01
The Bethe equations for the periodic XXX and XXZ spin chains admit singular solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to be physical, in which case they correspond to genuine eigenvalues and eigenvectors of the Hamiltonian.
Disconnected Loops with Twisted Mass Lattice QCD
Wilcox, W; Morgan, R; Lewis, R; Wilcox, Walter; Darnell, Dean; Morgan, Ron; Lewis, Randy
2005-01-01
We give a general introduction and discussion of the issues involved in using the twisted mass formulation of lattice fermions in the context of disconnected loop calculations, including a short orientation on the present experimental situation for nucleon strange quark form factors. A prototype calculation of the disconnected part of the nucleon scalar form factor is described.
Phase diagram of twisted mass lattice QCD
Sharpe, Stephen R.; Wu, Jackson M.
2004-11-01
We use the effective chiral Lagrangian to analyze the phase diagram of two-flavor twisted mass lattice QCD as a function of the normal and twisted masses, generalizing previous work for the untwisted theory. We first determine the chiral Lagrangian including discretization effects up to next-to-leading order (NLO) in a combined expansion in which m2π/(4πfπ)2˜aΛ (a being the lattice spacing, and Λ=ΛQCD). We then focus on the region where m2π/(4πfπ)2˜(aΛ)2, in which case competition between leading and NLO terms can lead to phase transitions. As for untwisted Wilson fermions, we find two possible phase diagrams, depending on the sign of a coefficient in the chiral Lagrangian. For one sign, there is an Aoki phase for pure Wilson fermions, with flavor and parity broken, but this is washed out into a crossover if the twisted mass is nonvanishing. For the other sign, there is a first order transition for pure Wilson fermions, and we find that this transition extends into the twisted mass plane, ending with two symmetrical second order points at which the mass of the neutral pion vanishes. We provide graphs of the condensate and pion masses for both scenarios, and note a simple mathematical relation between them. These results may be of importance to numerical simulations.
Gluon polarization and higher twist effects
Leader, Elliot; Stamenov, Dimiter
2008-01-01
We examine the influence of the recent CLAS and COMPASS experiments on our understanding of higher twist (HT) effects and the gluon polarization, and show how EIC could discriminate between negative and positive gluon polarizations. We comment on the issue of HT and the recent DSSV analysis.
Twisted Ribbons: Theory, Experiment and Applications
Chopin, Julien; Davidovitch, Benjamin; Silva, Flavio A.; Toledo Filho, Romildo D.; Kudrolli, Arshad
2014-03-01
We investigate, experimentally and theoretically, the buckling and wrinkling instabilities of a pre-stretched ribbon upon twisting and propose strategies for the fabrication of structured yarns. Our experiment consists in a thin elastic sheet in the form of a ribbon which is initially stretched by a fixed load and then subjected to a twist by rotating the ends through a prescribed angle. We show that a wide variety of shapes and instabilities can be obtained by simply varying the applied twist and tension. The observed structures which include helicoids with and without longitudinal and transverse wrinkles, and spontaneous creases, can be organized in a phase diagram with the tension and twist angle as control parameters [J. Chopin and A. Kudrolli, PRL (2013)]. Using a far-from-threshold analysis and a slender body approximation, we provide a comprehensive understanding of the longitudinal and transverse instabilities and show that several regimes emerge depending on subtle combinations of loading and geometrical parameters. Further, we show that the wrinkling instabilities can be manipulated to fabricate structured yarns which may be used to encapsulate amorphous materials or serve as efficient reinforcements for cement-based composites. COPPETEC / CNPq - Science Without Border Program
HOMOCLINIC TWIST BIFURCATIONS WITH Z(2) SYMMETRY
ARONSON, DG; VANGILS, SA; KRUPA, M
1994-01-01
We analyze bifurcations occurring in the vicinity of a homoclinic twist point for a generic two-parameter family of Z2 equivariant ODEs in four dimensions. The results are compared with numerical results for a system of two coupled Josephson junctions with pure capacitive load.
Redefining B twisted topological sigma models
Jonghe, F. de; Termonia, P.; Troost, W.; Vandoren, S.
2007-01-01
The recently proposed procedure to perform the topological B-twist in rigid N = 2 models is applied to the case of the o model on a Kähler manifold. This leads to an alternative description of Witten’s topological o model, which allows for a proper BRST interpretation and ghost number assignement. W
Generalized Weyl modules for twisted current algebras
Makedonskyi, I. A.; Feigin, E. B.
2017-08-01
We introduce the notion of generalized Weyl modules for twisted current algebras. We study their representation-theoretic and combinatorial properties and also their connection with nonsymmetric Macdonald polynomials. As an application, we compute the dimension of the classical Weyl modules in the remaining unknown case.
Analysis of Cohesion inOliver Twist
Institute of Scientific and Technical Information of China (English)
程文文
2016-01-01
Cohesion is an important concept in the study of stylistics. This thesis aims to study the applications of cohesion in the Charles Dicken’ world-famous novelOliver Twist, including both the grammatical and lexical cohesive devices in the work.
Energy Release in Driven Twisted Coronal Loops
Bareford, M. R.; Gordovskyy, M.; Browning, P. K.; Hood, A. W.
2016-01-01
We investigate magnetic reconnection in twisted magnetic fluxtubes, representing coronal loops. The main goal is to establish the influence of the field geometry and various thermodynamic effects on the stability of twisted fluxtubes and on the size and distribution of heated regions. In particular, we aim to investigate to what extent the earlier idealised models, based on the initially cylindrically symmetric fluxtubes, are different from more realistic models, including the large-scale curvature, atmospheric stratification, thermal conduction and other effects. In addition, we compare the roles of Ohmic heating and shock heating in energy conversion during magnetic reconnection in twisted loops. The models with straight fluxtubes show similar distribution of heated plasma during the reconnection: it initially forms a helical shape, which subsequently becomes very fragmented. The heating in these models is rather uniformly distributed along fluxtubes. At the same time, the hot plasma regions in curved loops are asymmetric and concentrated close to the loop tops. Large-scale curvature has a destabilising influence: less twist is needed for instability. Footpoint convergence normally delays the instability slightly, although in some cases, converging fluxtubes can be less stable. Finally, introducing a stratified atmosphere gives rise to decaying wave propagation, which has a destabilising effect.
Dickens's Dichotomous Formula for Social Reform In Oliver Twist
Directory of Open Access Journals (Sweden)
Taher Badinjki
2016-11-01
Full Text Available Oliver Twist was a direct appeal to society to take action against poverty, exploitation of children, oppression of women, and was meant to be a picture of the "dregs of life” in all their deformity and wretchedness. Among the most miserable inhabitants of the world of Oliver Twist, Nancy appears as a key figure. Dickens was anxious to expose the truth about such a woman because he believed it would be a service to society. Dickens's portrayal of Nancy illustrates the power of the dual conception of womanhood held at the time. On the one hand, a woman might be conceived as someone refined and somewhat remote from ordinary life like Rose Maylie. On the other hand, there was a certain fascination in a woman's degradation, even though that could be shown only indirectly. Nancy is a demonstration of the two elements combined together. Dickens took the ideal nature of womanhood and the depravity of the prostitute, and combined them in a remarkable dramatization which he had some right to claim was also true to life. The book is an astounding rebuttal of contemporary prejudice, and a call for more humane and liberal attitudes. These attitudes are based on the concepts that there is now a radically different way of looking at human nature, that everything ought to depend on what one is in oneself, and that it is only in love that humans can live purposefully and happily with each other.
Lee, Jae Ah; Baughman, Ray H.; Kim, Seon Jeong
2015-04-01
High performance torsional and tensile artificial muscles are described, which utilize thermally- or electrochemically-induced volume changes of twist-spun, guest-filled, carbon nanotube (CNT) yarns. These yarns were prepared by incorporating twist in carbon nanotube sheets drawn from spinnable CNT forests. Inserting high twist into the CNT yarn results in yarn coiling, which can dramatically amplify tensile stroke and work capabilities compared with that for the non-coiled twisted yarn. When electrochemically driven in a liquid electrolyte, these artificial muscles can generate a torsional rotation per muscle length that is over 1000 times higher than for previously reported torsional muscles. All-solid-state torsional electrochemical yarn muscles have provided a large torsional muscle stroke (53° per mm of yarn length) and a tensile stroke of up to 1.3% when lifting loads that are ~25 times heavier than can be lifted by the same diameter human skeletal muscle. Over a million torsional and tensile actuation cycles have been demonstrated for thermally powered CNT hybrid yarns muscles filled with paraffin wax, wherein a muscle spins a rotor at an average 11,500 revolutions/minute or delivers 3% tensile contraction at 1200 cycles/minute. At lower actuation rates, these thermally powered muscles provide tensile strokes of over 10%.
Higher Twist Distribution Amplitudes of the Nucleon in QCD
Braun, V M; Mahnke, N; Stein, E
2000-01-01
We present the first systematic study of higher-twist light-cone distribution amplitudes of the nucleon in QCD. We find that the valence three-quark state is described at small transverse separations by eight independent distribution amplitudes. One of them is leading twist-3, three distributions are twist-4 and twist-5, respectively, and one is twist-6. A complete set of distribution amplitudes is constructed, which satisfies equations of motion and constraints that follow from conformal expansion. Nonperturbative input parameters are estimated from QCD sum rules.
Thermal Performance and Fuzzy Logic Modelling for Wavy Twisted Tape Inserts in Single Phase Flow.
Directory of Open Access Journals (Sweden)
Gawai U.S.
2014-01-01
Full Text Available Heat exchangers are widely used in various industrial processes for heating and cooling applications. The major challenge in designing a heat exchanger is to make the equipment compact and achieve a high heat transfer rate with less pumping power.Various techniques have been proposed in recent years and are discussed under.Passive Techniques: These techniques do not require any direct input of external power; rather they use it from the system itself which ultimately leads to an higher fluid pressure drop. They geometrical alteration to the flow channel by incorporating inserts or additional devices like twisted tapes, twisted wires, circular rings etc. Active Techniques: External power is brought into action for the desired flow modification and the relative improvement in the rate of heat transfer. Enhancement of heat transfer can be achieved by(i Mechanical Aids: (ii Surface vibration:
Kuusk, Priit, 1938-
1999-01-01
Lihavõttefestivalidest Salzburgis, Viinis ja Luzernis. kontsertidest, esinejatest. Barcelonas avatud uuest kontserdimajast L"Auditori. Helilooja 300. sünniaastapäeva puhul on mitmel pool Euroopas välja toodud tema ooperite uuslavastusi. Muusikute tähtpäevi märtsis 1999
The androgen signaling pathway plays a critical role in sexual differentiation during development in mammals and is one of the better understood pathways in human development. Thus it was chosen as a model pathway to evaluate the potential of HTP in vitro assays as risk assessmen...
Thomas, C L; Graham, N S; Hayden, R; Meacham, M C; Neugebauer, K; Nightingale, M; Dupuy, L X; Hammond, J P; White, P J; Broadley, M R
2016-04-06
Root traits can be selected for crop improvement. Techniques such as soil excavations can be used to screen root traits in the field, but are limited to genotypes that are well-adapted to field conditions. The aim of this study was to compare a low-cost, high-throughput root phenotyping (HTP) technique in a controlled environment with field performance, using oilseed rape (OSR;Brassica napus) varieties. Primary root length (PRL), lateral root length and lateral root density (LRD) were measured on 14-d-old seedlings of elite OSR varieties (n = 32) using a 'pouch and wick' HTP system (∼40 replicates). Six field experiments were conducted using the same varieties at two UK sites each year for 3 years. Plants were excavated at the 6- to 8-leaf stage for general vigour assessments of roots and shoots in all six experiments, and final seed yield was determined. Leaves were sampled for mineral composition from one of the field experiments. Seedling PRL in the HTP system correlated with seed yield in four out of six (r = 0·50, 0·50, 0·33, 0·49;P HTP systems to screen this trait in both elite and more genetically diverse, non-field-adapted OSR. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company.
Ortmann, R; Martin, S; Radeke, E; Delini-Stula, A
1981-06-01
The effect of beta-adrenoceptor agonists on the behavioral effect of L-5-HTP in rats and mice was studied. All beta-agonists potentiated the behavioral syndrome elicited by L-5-HTP. However no indication for a correlation between their potencies to stimulate peripheral beta-receptors and their potencies to enchance L-5-HTP effect was found. The potentiating effect of salbutamol in rats was intensified by the MAO A inhibitor clorgyline, completely inhibited by (+/-)-propranolol and partly inhibited by WB-4101, while practolol was without effect. Lesions of 5-HT pathways by i.c.v. injections of 5,7-DHT impaired the potentiating effect of salbutamol in rats. In contrast, 6-OHDA lesions or alpha-methyl-p-tyrosine pretreatment were without effect. A central site of action of salbutamol is suggested by the fact that it intensified L-5-HTP effects also after i.c.v. administration. Therefore the results suggest that salbutamol facilitates 5-HT transmission in rat brain probably via stimulation of central beta receptors.
Sommerfelt, L; Ursin, R
1987-04-01
Sleep and waking stages in cats were studied 8 h following administration of zimeldine and alaproclate, in combination with saline or 5-hydroxy-1-tryptophan (5-HTP). Both drugs in combination with saline reduced rapid eye movement sleep and ponto-geniculo-occipital wave activity, and the effects were potentiated with 5-HTP. After administration of zimeldine in combination with 5-HTP there was an increase in synchronized waking (W-2), followed by an increase in slow wave sleep (SWS), at first SWS-1 with spindles and then highly synchronized SWS-2. The changes were interpreted as reflecting a serotonergic deactivating effect expressed by an electroencephalographic synchronizing effect. This is consistent with earlier studies following serotonin depletion and serotonin precursor loading. After alaproclate in combination with 5-HTP there were changes in W-2 and SWS-1 suggestive of the same process but much less pronounced. The difference between the two serotonin uptake inhibitors is interpreted as being due to regional differences in their uptake inhibition.
Richards, J B; Sabol, K E; Hand, T H; Jolly, D C; Marek, G J; Seiden, L S
1994-02-01
The effects of four serotonin (5-HT)-1A compounds (buspirone, gepirone, ipsapirone and zalospirone) were compared with 5-hydroxytryptophan (5-HTP) [a 5-HT precursor with antidepressant (AD) efficacy], and diazepam (a benzodiazepine anxiolytic), on a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule. Past research has shown that AD and anxiolytic compounds each have distinct effects on the DRL 72-s interresponse time (IRT) distribution profile. In the present paper, the profile of the IRT distribution was quantitatively characterized by three metrics: burst ratio, peak location and peak area. 5-HTP shifted the IRT distribution peak toward longer IRT durations, increased reinforcement rate and decreased response rate. The profile of the IRT distribution was not disrupted by 5-HTP. Diazepam disrupted the IRT distribution and increased bursting. In general, the arylpiperazine, 5-HT1A compounds increased reinforcement rate, decreased response rate and disrupted the profile of the IRT distribution. The effects of the four arylpiperazine 5-HT1A compounds on the IRT distribution profile were different from the AD profile of 5-HTP and the benzodiazepine anxiolytic profile of diazepam. Disruption of the IRT distribution by buspirone, gepirone, ipsapirone and zalospirone may result from decreased 5-HT transmission mediated by the presynaptic, somatodendritic 5-HT1A receptor.
Kuusk, Priit, 1938-
1999-01-01
Lihavõttefestivalidest Salzburgis, Viinis ja Luzernis. kontsertidest, esinejatest. Barcelonas avatud uuest kontserdimajast L"Auditori. Helilooja 300. sünniaastapäeva puhul on mitmel pool Euroopas välja toodud tema ooperite uuslavastusi. Muusikute tähtpäevi märtsis 1999
Fachinelli, C; Ison, M; Rodríguez Echandía, E L
1996-02-01
The acute administration of 5-HTP was reported to block in undernourished dominant pigeons the aggressive attacks induced in a submissive partner by food competition. In the present study, undernourished pigeons with previously consolidated dominance were submitted to subchronic and chronic 5-HTP treatment. Adult males (n = 28) were kept at 80% of their body weight by a restricted diet. These were divided in pairs made of a previously ranked dominant subject (total time spent in aggression higher than 200 s/20 min) and a submissive one of similar body weight (time spent in aggression between 90 and 150 s/20 min). The same pairs were exposed to a daily 20 min interaction during each experiment in an observation chamber bearing a central feeder. The time spent in aggressive behavior, feeder control behavior and eating behavior was recorded. Intratest body weight gain was also recorded. In Experiment 1, 8 pairs of pigeons were exposed to a daily trial for 4 successive days (pretreatment-scores). The dominant subjects were then injected subcutaneously, 30 min. before trials, with 7.5 mg/kg 5-HTP from day 5 to day 8 (Treatment scores). The Recovery scores were obtained through a 4-trial post-treatment schedule. In Experiment 2 different pigeons were used. The pretreatment and recovery scores were obtained according to a 16-trial schedule (16 days). Both 4-day (subchronic) and 16-day (chronic) 5-HTP treatments attenuated aggression by the dominant subjects and reduced their intra-test body weight gain but did not decrease dominance for feeder control. The recovery scores of total aggression in subchronic experiments returned to pretreatment scores. In chronic experiments, instead, the recovery scores of aggression remained lower than pretreatment scores, whereas body-weight-gain scores came back to pretreatment values. This suggests that dominant subjects submitted to chronic 5-HTP might have learned to maintain dominance and feeder control in a virtual absence of
Severson, Aaron F; Ling, Lorraine; van Zuylen, Vanessa; Meyer, Barbara J
2009-08-01
Faithful transmission of the genome through sexual reproduction requires reduction of genome copy number during meiosis to produce haploid sperm and eggs. Meiosis entails steps absent from mitosis to achieve this goal. When meiosis begins, sisters are held together by sister chromatid cohesion (SCC), mediated by the cohesin complex. Homologs then become linked through crossover recombination. SCC subsequently holds both sisters and homologs together. Separation of homologs and then sisters requires two successive rounds of chromosome segregation and the stepwise removal of Rec8, a meiosis-specific cohesin subunit. We show that HTP-3, a known component of the C. elegans axial element (AE), molecularly links these meiotic innovations. We identified HTP-3 in a genetic screen for factors necessary to maintain SCC until meiosis II. Our data show that interdependent loading of HTP-3 and cohesin is a principal step in assembling the meiotic chromosomal axis and in establishing SCC. HTP-3 recruits all known AE components to meiotic chromosomes and promotes cohesin loading, the first known involvement of an AE protein in this process. Furthermore, REC-8 and two paralogs, called COH-3 and COH-4, together mediate meiotic SCC, but they perform specialized functions. REC-8 alone is necessary and sufficient for the persistence of SCC after meiosis I. In htp-3 and rec-8 mutants, sister chromatids segregate away from one another in meiosis I (equational division), rather than segregating randomly, as expected if SCC were completely eliminated. AE assembly fails only when REC-8, COH-3, and COH-4 are simultaneously disrupted. Premature equational sister separation in rec8 mutants of other organisms suggests the involvement of multiple REC-8 paralogs, which may have masked a conserved requirement for cohesin in AE assembly.
General relativistic neutron stars with twisted magnetosphere
Pili, A G; Del Zanna, L
2014-01-01
Soft Gamma-Ray Repeaters and Anomalous X-Ray Pulsars are extreme manifestations of the most magnetized neutron stars: magnetars. The phenomenology of their emission and spectral properties strongly support the idea that the magnetospheres of these astrophysical objects are tightly twisted in the vicinity of the star. Previous studies on equilibrium configurations have so far focused on either the internal or the external magnetic field configuration, without considering a real coupling between the two fields. Here we investigate numerical equilibrium models of magnetized neutron stars endowed with a confined twisted magnetosphere, solving the general relativistic Grad-Shafranov equation both in the interior and in the exterior of the compact object. A comprehensive study of the parameters space is provided to investigate the effects of different current distributions on the overall magnetic field structure.
Twisted black hole is Taub-NUT
Ong, Yen Chin
2017-01-01
Recently a purportedly novel solution of the vacuum Einstein field equations was discovered: it supposedly describes an asymptotically flat twisted black hole in 4-dimensions whose exterior spacetime rotates in a peculiar manner—the frame dragging in the northern hemisphere is opposite from that of the southern hemisphere, which results in a globally vanishing angular momentum. Furthermore it was shown that the spacetime has no curvature singularity. We show that the geometry of this black hole spacetime is nevertheless not free of pathological features. In particular, it harbors a rather drastic conical singularity along the axis of rotation. In addition, there exist closed timelike curves due to the fact that the constant r and constant t surfaces are not globally Riemannian. In fact, none of these are that surprising since the solution is just the Taub-NUT geometry. As such, despite the original claim that the twisted black hole might have observational consequences, it cannot be.
Twisted mass QCD at finite temperature
Energy Technology Data Exchange (ETDEWEB)
Ilgenfritz, E.M.; Mueller-Preussker, M.; Petschlies, M. [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Lombardo, M.P. [Istituto Nazionale di Fisica Nucleare, LNF, Frascati (Italy); Philipsen, O.; Zeidlewicz, L. [Muenster Univ. (Germany). Inst. fuer Theoretische Physik 1; Sternbeck, A. [Adelaide Univ. (Australia). CSSM School of Chemistry and Physics
2007-10-15
We discuss the use of Wilson fermions with twisted mass for simulations of QCD thermodynamics. As a prerequisite for a future analysis of the finite-temperature transition making use of automatic {partial_derivative} (a) improvement, we investigate the phase structure in the space spanned by the hopping parameter {kappa}, the coupling {beta}, and the twisted mass parameter {mu}. We present results for N{sub f}=2 degenerate quarks on a 16{sup 3} x 8 lattice, for which we investigate the possibility of an Aoki phase existing at strong coupling and vanishing {mu}, as well as of a thermal phase transition at moderate gauge couplings and non-vanishing {mu}. (orig.)
Magnetic Field Twisting by Intergranular Downdrafts
Taroyan, Youra; Williams, Thomas
2016-10-01
The interaction of an intergranular downdraft with an embedded vertical magnetic field is examined. It is demonstrated that the downdraft may couple to small magnetic twists leading to an instability. The descending plasma exponentially amplifies the magnetic twists when it decelerates with depth due to increasing density. Most efficient amplification is found in the vicinity of the level, where the kinetic energy density of the downdraft reaches equipartition with the magnetic energy density. Continual extraction of energy from the decelerating plasma and growth in the total azimuthal energy occurs as a consequence of the wave-flow coupling along the downdraft. The presented mechanism may drive vortices and torsional motions that have been detected between granules and in simulations of magnetoconvection.
Factorising the 3D Topologically Twisted Index
Cabo-Bizet, Alejandro
2016-01-01
In this work, path integral representations of the 3D topologically twisted index were studied. First, the index can be "factorised" into a couple of "blocks". The "blocks" being the partition functions of a type A semi-topological twisting of 3D N = 2 SYM placed on $\\mathbb{S}_2\\times (0, \\pi)$ and $\\mathbb{S}_2 \\times (\\pi, 2 \\pi)$ respectively. Second, as the path integral of the aforementioned theory over $\\mathbb{S}_2$ times $\\mathbb{S}_1$ with a point excluded. In this way we recover the sum over fluxes from integration over the real path and without sacrificing positive definiteness of the bosonic part of the localising action. We also reproduce the integration over the complex contour by using the localising term with positive definite bosonic part.
Tinkertoys for the Twisted D-Series
Chacaltana, Oscar; Trimm, Anderson
2013-01-01
We study 4D N=2 superconformal field theories that arise from the compactification of 6D N=(2,0) theories of type D_N on a Riemann surface, in the presence of punctures twisted by a Z_2 outer automorphism. Unlike the untwisted case, the family of SCFTs is in general parametrized, not by M_{g,n}, but by a branched cover thereof. The classification of these SCFTs is carried out explicitly in the case of the D_4 theory, in terms of three-punctured spheres and cylinders, and we provide tables of properties of twisted punctures for the D_5 and D_6 theories. We find realizations of Spin(8) and Spin(7) gauge theories with matter in all combinations of vector and spinor representations with vanishing beta-function, as well as Sp(3) gauge theories with matter in the 3-index traceless antisymmetric representation.
Overlap fermions on a twisted mass sea
Bär, O; Schäefer, S; Scorzato, L; Shindler, A
2006-01-01
We present first results of a mixed action project. We analyze gauge configurations generated with two flavors of dynamical twisted mass fermions. Neuberger's overlap Dirac operator is used for the valence sector. The various choices in the setup of the simulation are discussed. We employ chiral perturbation theory to describe the effects of using different actions in the sea and valence sector at non-zero lattice spacing.
Disconnected diagrams with twisted-mass fermions
Abdel-Rehim, Abdou; Constantinou, Martha; Finkenrath, Jacob; Hadjiyiannakou, Kyriakos; Jansen, Karl; Kallidonis, Christos; Koutsou, Giannis; Avilés-Casco, Alejandro Vaquero
2016-01-01
The latest results from the Twisted-Mass collaboration on disconnected diagrams at the physical value of the pion mass are presented. In particular, we focus on the sigma terms, the axial charges and the momentum fraction, all of them for the nucleon. A detailed error analysis for each observable follows, showing the strengths and weaknesses of the one-end trick. Alternatives are discussed.
DNA Packaging in Bacteriophage: Is Twist Important?
Spakowitz, Andrew James; Wang, Zhen-Gang
2005-01-01
We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with...
On rectangular HOMFLY for twist knots
Kononov, Ya
2016-01-01
As a new step in the study of rectangularly-colored knot polynomials, we reformulate the prescription of arXiv:1606.06015 for twist knots in the double-column representations $R=[rr]$ in terms of skew Schur polynomials. These, however, are mysteriously shifted from the standard topological locus, what makes further generalization to arbitrary $R=[r^s]$ not quite straightforward.
Ferromagnetic nanoparticles suspensions in twisted nematic
Cîrtoaje, Cristina; Petrescu, Emil; Stan, Cristina; Creangă, Dorina
2016-05-01
Ferromagnetic nanoparticles insertions in nematic liquid crystals (NLC) in twisted configuration are studied and a theoretical model is proposed to explain the results. Experimental observation revealed that nanoparticles tend to overcrowd in long strings parallel to the rubbing direction of the alignment substrate of the LC cell. Their behavior under external field was studied and their interaction with their nematic host is described using elastic continuum theory.
Twisted Radiation by Electrons in Spiral Motion
Katoh, M; Mirian, N S; Konomi, T; Taira, Y; Kaneyasu, T; Hosaka, M; Yamamoto, N; Mochihashi, A; Takashima, Y; Kuroda, K; Miyamoto, A; Miyamoto, K; Sasaki, S
2016-01-01
We theoretically show that a single free electron in circular/spiral motion radiates an electromagnetic wave possessing helical phase structure and carrying orbital angular momentum. We experimentally demonstrate it by double-slit diffraction on radiation from relativistic electrons in spiral motion. We show that twisted photons should be created naturally by cyclotron/synchrotron radiations or Compton scatterings in various situations in astrophysics. We propose promising laboratory vortex photon sources in various wavelengths ranging from radio wave to gamma-rays.
Geometric somersaults of a polymer chain through cyclic twisting motions.
Yanao, Tomohiro; Hino, Taiko
2017-01-01
This study explores the significance of geometric angle shifts, which we call geometric somersaults, arising from cyclic twisting motions of a polymer chain. A five-bead polymer chain serves as a concise and minimal model of a molecular shaft throughout this study. We first show that this polymer chain can change its orientation about its longitudinal axis largely, e.g., 120^{∘}, under conditions of zero total angular momentum by changing the two dihedral angles in a cyclic manner. This phenomenon is an example of the so-called "falling cat" phenomenon, where a falling cat undergoes a geometric somersault by changing its body shape under conditions of zero total angular momentum. We then extend the geometric somersault of the polymer chain to a noisy and viscous environment, where the polymer chain is steered by external driving forces. This extension shows that the polymer chain can achieve an orientation change keeping its total angular momentum and total external torque fluctuating around zero in a noisy and viscous environment. As an application, we argue that the geometric somersault of the polymer chain by 120^{∘} may serve as a prototypical and coarse-grained model for the rotary motion of the central shaft of ATP synthase (F_{O}F_{1}-ATPase). This geometric somersault is in clear contrast to the standard picture for the rotary motion of the central shaft as a rigid body, which generally incurs nonzero total angular momentum and nonzero total external torque. The power profile of the geometric somersault implies a preliminary mechanism for elastic power transmission. The results of this study may be of fundamental interest in twisting and rotary motions of biomolecules.
Twisted spectral geometry for the standard model
Martinetti, Pierre
2015-01-01
The Higgs field is a connection one-form as the other bosonic fields, provided one describes space no more as a manifold M but as a slightly non-commutative generalization of it. This is well encoded within the theory of spectral triples: all the bosonic fields of the standard model - including the Higgs - are obtained on the same footing, as fluctuations of a generalized Dirac operator by a matrix-value algebra of functions on M. In the commutative case, fluctuations of the usual free Dirac operator by the complex-value algebra A of smooth functions on M vanish, and so do not generate any bosonic field. We show that imposing a twist in the sense of Connes-Moscovici forces to double the algebra A, but does not require to modify the space of spinors on which it acts. This opens the way to twisted fluctuations of the free Dirac operator, that yield a perturbation of the spin connection. Applied to the standard model, a similar twist yields in addition the extra scalar field needed to stabilize the electroweak v...
DEFF Research Database (Denmark)
Elmholdt, Claus Westergård; Fogsgaard, Morten
2016-01-01
In this chapter, we will explore the dynamics of power in processes of creativity, and show its paradoxical nature as both a bridge and a barrier to creativity in organisations. Recent social psychological experimental research (Slighte, de Dreu & Nijstad, 2011) on the relation between power...... and creativity suggests that when managers give people the opportunity to gain power and explicate that there is reason to be more creative, people will show a boost in creative behaviour. Moreover, this process works best in unstable power hierarchies, which implies that power is treated as a negotiable...... and floating source for empowering people in the organisation. We will explore and discuss here the potentials, challenges and pitfalls of power in relation to creativity in the life of organisations today. The aim is to demonstrate that power struggles may be utilised as constructive sources of creativity...
Cich, Matthew J.; Guillaume, Alexandre; Drouin, Brian; Benner, D. Chris
2017-06-01
Multispectrum analysis can be a challenge for a variety of reasons. It can be computationally intensive to fit a proper line shape model especially for high resolution experimental data. Band-wide analyses including many transitions along with interactions, across many pressures and temperatures are essential to accurately model, for example, atmospherically relevant systems. Labfit is a fast multispectrum analysis program originally developed by D. Chris Benner with a text-based interface. More recently at JPL a graphical user interface was developed with the goal of increasing the ease of use but also the number of potential users. The HTP lineshape model has been added to Labfit keeping it up-to-date with community standards. Recent analyses using labfit will be shown to demonstrate its ability to competently handle large experimental datasets, including high order lineshape effects, that are otherwise unmanageable.
Camilo, Cesar M; Lima, Gustavo M A; Maluf, Fernando V; Guido, Rafael V C; Polikarpov, Igor
2016-01-01
Following burgeoning genomic and transcriptomic sequencing data, biochemical and molecular biology groups worldwide are implementing high-throughput cloning and mutagenesis facilities in order to obtain a large number of soluble proteins for structural and functional characterization. Since manual primer design can be a time-consuming and error-generating step, particularly when working with hundreds of targets, the automation of primer design process becomes highly desirable. HTP-OligoDesigner was created to provide the scientific community with a simple and intuitive online primer design tool for both laboratory-scale and high-throughput projects of sequence-independent gene cloning and site-directed mutagenesis and a Tm calculator for quick queries.
Temperature measurements of a high-power microwave feedhorn window
Hoppe, Daniel J.; Perez, Raul M.; Glazer, Stuart D.
1990-06-01
Temperature measurements of a high-power microwave feedhorn window, obtained using an imaging IR radiometer during transmitter operation at 365 kW CW and 8.5 GHz, are discussed. The window under investigation was constructed of HTP-6, a high-thermal-performance material developed to shield the Space Shuttle Orbiter from the heat of reentry. The measurement technique is described, and experimental results are presented. The window performed adequately at 365 kW CW with a center temperature of 475 C. The tests verify that HTP-6 can be used as a window material or a support structure in high-power waveguides at power densities of 1.47 kW/sq cm for extended periods of time, with no change in its mechanical characteristics.
Yang, Y; Bailey, W; Beduza, C; Ballarino, A
2012-01-01
Following the development of twisted-pair cables prepared with High Temperature Superconducting (HTS) tapes and their initial tests at 4.2 K in liquid helium at CERN, the cable samples of 2 m lengths were subsequently tested in flowing helium gas at temperatures between 10 K and 77 K at University of Southampton. A cryostat with optimized hybrid HTS current leads was purposely built for the tests up to 2.5 kA. The cryostat has two separate helium flow conduits, each accommodating a twisted pair and allowing independent temperature control. With the completion of the tests on the twisted-pair cables, a 5 m long semi-flexible Nexans cryostat was also set up for the testing of prototype HTS links assembled at CERN. The link, which is optimized for application to the remote powering of LHC 600 A electrical circuits, consists of a compact multi-cable assembly with up to 25 twisted-pair 600 A HTS tapes. The cables are cooled by a forced-flow of helium gas the inlet temperature of which can be changed in order to co...
Design optimization for active twist rotor blades
Mok, Ji Won
This dissertation introduces the process of optimizing active twist rotor blades in the presence of embedded anisotropic piezo-composite actuators. Optimum design of active twist blades is a complex task, since it involves a rich design space with tightly coupled design variables. The study presents the development of an optimization framework for active helicopter rotor blade cross-sectional design. This optimization framework allows for exploring a rich and highly nonlinear design space in order to optimize the active twist rotor blades. Different analytical components are combined in the framework: cross-sectional analysis (UM/VABS), an automated mesh generator, a beam solver (DYMORE), a three-dimensional local strain recovery module, and a gradient based optimizer within MATLAB. Through the mathematical optimization problem, the static twist actuation performance of a blade is maximized while satisfying a series of blade constraints. These constraints are associated with locations of the center of gravity and elastic axis, blade mass per unit span, fundamental rotating blade frequencies, and the blade strength based on local three-dimensional strain fields under worst loading conditions. Through pre-processing, limitations of the proposed process have been studied. When limitations were detected, resolution strategies were proposed. These include mesh overlapping, element distortion, trailing edge tab modeling, electrode modeling and foam implementation of the mesh generator, and the initial point sensibility of the current optimization scheme. Examples demonstrate the effectiveness of this process. Optimization studies were performed on the NASA/Army/MIT ATR blade case. Even though that design was built and shown significant impact in vibration reduction, the proposed optimization process showed that the design could be improved significantly. The second example, based on a model scale of the AH-64D Apache blade, emphasized the capability of this framework to
Expression of Twist Gene in Primary Liver Cancer
Institute of Scientific and Technical Information of China (English)
XU Jing; CHEN Xiaoping
2007-01-01
In order to investigate the possibility of overexpression of Twist in primary liver cancer (PLC), the Twist expression was detected by using immunohistochemical analysis and RT-PCR assay in 45 patients with PLC. Control tissues were obtained from 9 patients with liver hemangioma. It was found that in 36 (80.0%) out of 45 PLC patients, cancerous regions showed positive cytoplasm and nucleus staining for Twist with a diffuse pattern. In noncancerous adjacent areas and control liver tissues, the expression of Twist was 57.8% and 22.2% respectively. The results of RT-PCR assay re- vealed that the expression of Twist was stronger in the cancerous tissues than that in the noncancer- ous adjacent tissues. It was suggested that the expression of Twist was up-regulated in PLC, which play an important role in the progression of PLC.
Negative Regulatory Role of TWIST1 on SNAIL Gene Expression.
Forghanifard, Mohammad Mahdi; Ardalan Khales, Sima; Farshchian, Moein; Rad, Abolfazl; Homayouni-Tabrizi, Masoud; Abbaszadegan, Mohammad Reza
2017-01-01
Epithelial-mesenchymal transition (EMT) is crucial for specific morphogenetic movements during embryonic development as well as pathological processes of tumor cell invasion and metastasis. TWIST and SNAIL play vital roles in both developmental and pathological EMT. Our aim in this study was to investigate the functional correlation between TWIST1 and SNAIL in human ESCC cell line (KYSE-30). The packaging cell line GP293T was cotransfected with either control retroviral pruf-IRES-GFP plasmid or pruf-IRES-GFP-hTWIST1 and pGP plasmid. The KYSE-30 ESCC cells were transduced with produced viral particles and examined with inverted fluorescence microscope. DNA was extracted from transduced KYSE-30 cells and analyzed for copy number of integrated retroviral sequences in the target cell genome. The concentration of retroviral particles was determined by Real-time PCR. After RNA extraction and cDNA synthesis, the mRNA expression of TWIST1 and SNAIL was assessed by comparative real-time PCR amplification. Ectopic expression of TWIST1 in KYSE-30, dramatically reduces SNAIL expression. Retroviral transduction enforced TWIST1 overexpression in GFP-hTWIST1 nearly 9 folds in comparison with GFP control cells, and interestingly, this TWIST1 enforced expression caused a - 7 fold decrease of SNAIL mRNA expression in GFP-hTWIST1 compared to GFP control cells. Inverse correlation of TWIST1 and SNAIL mRNA levels may introduce novel molecular gene expression pathway controlling EMT process during ESCC aggressiveness and tumorigenesis. Consequently, these data extend the spectrum of biological activities of TWIST1 and propose that therapeutic repression of TWIST1 may be an effective strategy to inhibit cancer cell invasion and metastasis.
A twist tale of cancer metastasis and tumor angiogenesis.
Tseng, Jen-Chieh; Chen, Hsiao-Fan; Wu, Kou-Juey
2015-11-01
Twist1 is an evolutionally conserved transcription factor. Originally identified in Drosophila as a key regulator for mesoderm development, it was later implicated in many human diseases, including Saethre-Chotzen syndrome and cancer. Twist1's involvement in cancer has been well recognized. Driven by hypoxia-induced factor-1 (HIF-1), Twist1 has been considered as a proto-oncogene and its overexpression has been observed in a wide variety of human cancers. High expression level of Twist1 is closely related to tumor aggressiveness and metastatic potential. In cancer cells, Twist1 has been shown to function as a key regulator of epithelial-mesenchymal transition (EMT), a critical process for metastasis initiation. Twist1 has also been implicated in maintaining cancer stemness for self-renewal and chemoresistance. This review first summarizes the roles of Twist1 in embryo development and Saethre-Chotzen syndrome followed by a discussion of Twist1's critical functions in cancer. In particular, the review focuses on the recent discovery of Twist1's capability to promote endothelial transdifferentiation of cancer cells beyond EMT.
Twist1 activity thresholds define multiple functions in limb development
Krawchuk, Dayana; Weiner, Shoshana J; Chen, You-Tzung; Lu, Benson; Costantini, Frank; Behringer, Richard R.; Laufer, Ed
2010-01-01
The basic helix-loop-helix transcription factor Twist1 is essential for normal limb development. Twist1−/− embryos die at midgestation. However, studies on early limb buds found that Twist1−/− mutant limb mesenchyme has an impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loop between the mesenchyme and AER, and reduces and shifts anteriorly Shh expression in the zone of polarizing activity. We have combined Twist1 null, hypomorph and conditional...
Optical Möbius strips and twisted ribbon cloaks.
Freund, Isaac
2014-02-15
Optical Möbius strips that surround points of circular polarization, C points, in a generic three-dimensional optical field are cloaked by lines of twisted ribbons attached to the C points. When cloaking occurs, the observable signed twist index that counts the number of half-twists (one or three), and also measures the handedness (right or left), of a generic Möbius strip is determined by the twisted ribbon cloaks. Although some cloaks can be detached, they can never all be removed.
Twisted rudder for reducing fuel-oil consumption
Directory of Open Access Journals (Sweden)
Kim Jung-Hun
2014-09-01
Full Text Available Three twisted rudders fit for large container ships have been developed; 1 the Z-twisted rudder that is an asymmetry type taking into consideration incoming flow angles of the propeller slipstream, 2 the ZB-twisted rudder with a rudder bulb added onto the Z-twisted rudder, and 3 the ZB-F twisted rudder with a rudder fin attached to the ZB-twisted rudder. The twisted rudders have been designed computationally with the hydrodynamic characteristics in a self-propulsion condition in mind. The governing equation is the Navier-Stokes equations in an unsteady turbulent flow. The turbulence model applied is the Reynolds stress. The calculation was carried out in towing and self-propulsion conditions. The sliding mesh technique was employed to simulate the flow around the propeller. The speed performances of the ship with the twisted rudders were verified through model tests in a towing tank. The twisted versions showed greater performance driven by increased hull efficiency from less thrust deduction fraction and more effective wake fraction and decreased propeller rotating speed
Finite-dimensional representations of twisted hyper loop algebras
Bianchi, Angelo
2012-01-01
We investigate the category of finite-dimensional representations of twisted hyper loop algebras, i.e., the hyperalgebras associated to twisted loop algebras over finite-dimensional simple Lie algebras. The main results are the classification of the irreducible modules, the definition of the universal highest-weight modules, called the Weyl modules, and, under a certain mild restriction on the characteristic of the ground field, a proof that the simple modules and the Weyl modules for the twisted hyper loop algebras are isomorphic to appropriate simple and Weyl modules for the non-twisted hyper loop algebras, respectively, via restriction of the action.
Modelling of Nonthermal Microwave Emission From Twisted Magnetic Loops
Sharykin, I N
2016-01-01
Microwave gyrosynchrotron radio emission generated by nonthermal electrons in twisted magnetic loops is modelled using the recently developed simulation tool GX Simulator. We consider isotropic and anisotropic pitch-angle distributions. The main scope of the work is to understand impact of the magnetic field twisted topology on resulted radio emission maps. We have found that nonthermal electrons inside twisted magnetic loops produce gyrosynchrotron radio emission with peculiar polarization distribution. The polarization sign inversion line is inclined relatively to the axis of the loop. Radio emission source is more compact in the case of less twisted loop, considering anisotropic pitch-angle distribution of nonthermal electrons.
Twist decomposition of proton structure from BFKL and BK amplitudes
Motyka, Leszek
2014-01-01
An analysis of twist composition of Balitsky-Kovchegov (BK) amplitude is performed in the double logarithmic limit. In this limit the BK evolution of color dipole -- proton scattering is equivalent to BFKL evolution which follows from vanishing of the Bartels vertex in the collinear limit. We perform twist decomposition of the BFKL/BK amplitude for proton structure functions and find compact analytic expressions that provide accurate approximations for higher twist amplitudes. The BFKL/BK higher twist amplitudes are much smaller than those following from eikonal saturation models.
Time-varying wing-twist improves aerodynamic efficiency of forward flight in butterflies.
Directory of Open Access Journals (Sweden)
Lingxiao Zheng
Full Text Available Insect wings can undergo significant chordwise (camber as well as spanwise (twist deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads to particularly large wing deformations, making them an ideal test case for investigation of these effects. Here we use computational models derived from experiments on free-flying butterflies to understand the effect of time-varying twist and camber on the aerodynamic performance of these insects. High-speed videogrammetry is used to capture the wing kinematics, including deformation, of a Painted Lady butterfly (Vanessa cardui in untethered, forward flight. These experimental results are then analyzed computationally using a high-fidelity, three-dimensional, unsteady Navier-Stokes flow solver. For comparison to this case, a set of non-deforming, flat-plate wing (FPW models of wing motion are synthesized and subjected to the same analysis along with a wing model that matches the time-varying wing-twist observed for the butterfly, but has no deformation in camber. The simulations show that the observed butterfly wing (OBW outperforms all the flat-plate wings in terms of usable force production as well as the ratio of lift to power by at least 29% and 46%, respectively. This increase in efficiency of lift production is at least three-fold greater than reported for other insects. Interestingly, we also find that the twist-only-wing (TOW model recovers much of the performance of the OBW, demonstrating that wing-twist, and not camber is key to forward flight in these insects. The implications of this on the design of flapping wing micro-aerial vehicles are discussed.
Branch point twist field correlators in the massive free Boson theory
Bianchini, Davide; Castro-Alvaredo, Olalla A.
2016-12-01
Well-known measures of entanglement in one-dimensional many body quantum systems, such as the entanglement entropy and the logarithmic negativity, may be expressed in terms of the correlation functions of local fields known as branch point twist fields in a replica quantum field theory. In this "replica" approach the computation of measures of entanglement generally involves a mathematically non-trivial analytic continuation in the number of replicas. In this paper we consider two-point functions of twist fields and their analytic continuation in the 1 + 1 dimensional massive (non-compactified) free Boson theory. This is one of the few theories for which all matrix elements of twist fields are known so that we may hope to compute correlation functions very precisely. We study two particular two-point functions which are related to the logarithmic negativity of semi-infinite disjoint intervals and to the entanglement entropy of one interval. We show that our prescription for the analytic continuation yields results which are in full agreement with conformal field theory predictions in the short-distance limit. We provide numerical estimates of universal quantities and their ratios, both in the massless (twist field structure constants) and the massive (expectation values of twist fields) theory. We find that particular ratios are given by divergent form factor expansions. We propose such divergences stem from the presence of logarithmic factors in addition to the expected power-law behaviour of two-point functions at short-distances. Surprisingly, at criticality these corrections give rise to a log (log ℓ) correction to the entanglement entropy of one interval of length ℓ. This hitherto overlooked result is in agreement with results by Calabrese, Cardy and Tonni and has been independently derived by Blondeau-Fournier and Doyon [25].
Equilibrium shapes of twisted magnetic filaments
Energy Technology Data Exchange (ETDEWEB)
Belovs, Mihails; Cirulis, Teodors; Cebers, Andrejs [University of Latvia, Zellu 8, LV-1002 (Latvia)], E-mail: aceb@tesla.sal.lv
2009-06-12
It is shown that ferromagnetic filaments with free and unclamped ends undergo buckling instabilities under the action of twist. Solutions of nonlinear equations describing the buckled shapes are found, and it is shown that the transition to the buckled shape is subcritical if the magnetization is parallel to the field and supercritical when the magnetization of the straight filament is opposite to the external field. Solutions with the localized curvature distribution are found in the case of long filaments. The class of solutions corresponding to helices is described, and the behavior of coiled ferromagnetic and superparamagnetic filaments is compared.
Non-destructive identification of twisted light.
Li, Pengyun; Wang, Bo; Song, Xinbing; Zhang, Xiangdong
2016-04-01
The non-destructive identification of the orbital angular momentum (OAM) is essential to various applications in the optical information processing. Here, we propose and demonstrate experimentally an efficient method to identify non-destructively the OAM by using a modified Mach-Zehnder interferometer. Our schemes are applicable not only to the case with integer charges, but also to optical vortices with noninteger charges. Our Letter presents the first experimental demonstration of the non-destructive identification of twisted light with integer or noninteger topological charges, which has potential applications in the OAM-based data transmission for optical communications.
Instanton corrections to twist-two operators
Alday, Luis F
2016-01-01
We present the calculation of the leading instanton contribution to the scaling dimensions of twist-two operators with arbitrary spin and to their structure constants in the OPE of two half-BPS operators in $\\mathcal N=4$ SYM. For spin-two operators we verify that, in agreement with $\\mathcal N=4$ superconformal Ward identities, the obtained expressions coincide with those for the Konishi operator. For operators with high spin we find that the leading instanton correction vanishes. This arises as the result of a rather involved calculation and requires a better understanding.
Berry phase transition in twisted bilayer graphene
Rode, Johannes C.; Smirnov, Dmitri; Schmidt, Hennrik; Haug, Rolf J.
2016-09-01
The electronic dispersion of a graphene bilayer is highly dependent on rotational mismatch between layers and can be further manipulated by electrical gating. This allows for an unprecedented control over electronic properties and opens up the possibility of flexible band structure engineering. Here we present novel magnetotransport data in a twisted bilayer, crossing the energetic border between decoupled monolayers and coupled bilayer. In addition a transition in Berry phase between π and 2π is observed at intermediate magnetic fields. Analysis of Fermi velocities and gate induced charge carrier densities suggests an important role of strong layer asymmetry for the observed phenomena.
Quantum mass correction for the twisted kink
Pawellek, Michael
2008-01-01
We present an analytic result for the 1-loop quantum mass correction in semiclassical quantization for the twisted \\phi^4 kink on S^1 without explicit knowledge of the fluctuation spectrum. For this purpose we use the contour integral representation of the spectral zeta function. By solving the Bethe ansatz equations for the n=2 Lame equation we obtain an analytic expression for the corresponding spectral discriminant. We discuss the renormalization issues of this model. An energetically preferred size for the compact space is finally obtained.
Institute of Scientific and Technical Information of China (English)
马永杰; 马红梅
2013-01-01
利用 HTP 工艺将 X80级管线钢轧制成16 mm 厚的板坯,对其组织和性能进行研究,结果表明：经高温轧制的 X80级管线钢的屈服强度达到600 MPa 以上,其屈强比为0.86,韧脆转变温度低于-60℃,且达到了很好的强韧性匹配；钢中低的硫、磷和高的锰含量及细小的组织能有效的降低韧脆转变温度；钢中存在两种典型的析出物,一类析出物是以 TiN 为主,在 TiN 周围有少量的(Nb、V)(C、N)的复合析出物,另一类析出物为大量的 NbC 和少量TiC、VC同时析出形成的复合析出物；这些很细小的析出物对钢的组织细化和强化起到了重要作用.%The structure and mechanical properties of X80 pipeline steel through HTP rolled into 16 mm thick slab were tested. The results show that the yield strength of tested has reached above 600 MPa,and the ratio of tensile strength to yield strength is 0.86,and ductile-brittle transition temperature is lower than -60 ℃,and good strength and toughness are obtained. Low contents of P,S,high content of Mn and fine microstructure have good effect on reducing the ductile-brittle transitiop temperature. Two different precipitations are observed in X80 pipeline steel:a class of TiN is the main precipitations with a small number of(Nb,V)(C,N) complex precipitations in the TiN around,and the other is the complex formed precipitations with large number of NbC precipitations and a small amount of TiC,VC. Remarkable strengthening and refinement can be caused by these precipitations.
Suzuki, Yasuhiro; Kagawa, Naoko; Fujino, Toru; Sumiya, Tsuyoshi; Andoh, Taichi; Ishikawa, Kumiko; Kimura, Rie; Kemmochi, Kiyokazu; Ohta, Tsutomu; Tanaka, Shigeo
2005-07-11
There is an increasing demand for easy, high-throughput (HTP) methods for protein engineering to support advances in the development of structural biology, bioinformatics and drug design. Here, we describe an N- and C-terminal cloning method utilizing Gateway cloning technology that we have adopted for chimeric and mutant genes production as well as domain shuffling. This method involves only three steps: PCR, in vitro recombination and transformation. All three processes consist of simple handling, mixing and incubation steps. We have characterized this novel HTP method on 96 targets with >90% success. Here, we also discuss an N- and C-terminal cloning method for domain shuffling and a combination of mutation and chimeragenesis with two types of plasmid vectors.
Thomas, C. L.; Graham, N. S.; Hayden, R.; Meacham, M. C.; Neugebauer, K.; Nightingale, M.; Dupuy, L. X.; Hammond, J. P.; White, P. J.; Broadley, M. R.
2016-01-01
Background and Aims Root traits can be selected for crop improvement. Techniques such as soil excavations can be used to screen root traits in the field, but are limited to genotypes that are well-adapted to field conditions. The aim of this study was to compare a low-cost, high-throughput root phenotyping (HTP) technique in a controlled environment with field performance, using oilseed rape (OSR; Brassica napus) varieties. Methods Primary root length (PRL), lateral root length and lateral root density (LRD) were measured on 14-d-old seedlings of elite OSR varieties (n = 32) using a ‘pouch and wick’ HTP system (∼40 replicates). Six field experiments were conducted using the same varieties at two UK sites each year for 3 years. Plants were excavated at the 6- to 8-leaf stage for general vigour assessments of roots and shoots in all six experiments, and final seed yield was determined. Leaves were sampled for mineral composition from one of the field experiments. Key Results Seedling PRL in the HTP system correlated with seed yield in four out of six (r = 0·50, 0·50, 0·33, 0·49; P root traits might therefore be of limited additional selection value, given that vigour can be measured easily on shoots/canopies. In contrast, LRD cannot be assessed easily in the field and, if LRD can improve nutrient uptake, then it may be possible to use HTP systems to screen this trait in both elite and more genetically diverse, non-field-adapted OSR. PMID:27052342
Needleless electrospinning with twisted wire spinneret.
Holopainen, Jani; Penttinen, Toni; Santala, Eero; Ritala, Mikko
2015-01-16
A needleless electrospinning setup named 'Needleless Twisted Wire Electrospinning' was developed. The polymer solution is electrospun from the surface of a twisted wire set to a high voltage and collected on a cylindrical collector around the wire. Multiple Taylor cones are simultaneously self-formed on the downward flowing solution. The system is robust and simple with no moving parts aside from the syringe pump used to transport the solution to the top of the wire. The structure and process parameters of the setup and the results on the preparation of polyvinyl pyrrolidone (PVP), hydroxyapatite (HA) and bioglass fibers with the setup are presented. PVP fiber sheets with areas of 40 × 120 cm(2) and masses up to 1.15 g were prepared. High production rates of 5.23 g h(-1) and 1.40 g h(-1) were achieved for PVP and HA respectively. The major limiting factor of the setup is drying of the polymer solution on the wire during the electrospinning process which will eventually force to interrupt the process for cleaning of the wire. Possible solutions to this problem and other ways to develop the setup are discussed. The presented system provides a simple way to increase the production rate and area of fiber sheet as compared with the conventional needle electrospinning.
Holographic generation of highly twisted electron beams
Grillo, Vincenzo; Mafakheri, Erfan; Frabboni, Stefano; Karimi, Ebrahim; Boyd, Robert W
2014-01-01
Free electrons can possess an intrinsic orbital angular momentum, similar to those in an electron cloud, upon free-space propagation. The wavefront corresponding to the electron's wavefunction forms a helical structure with a number of twists given by the \\emph{angular speed}. Beams with a high number of twists are of particular interest because they carry a high magnetic moment about the propagation axis. Among several different techniques, electron holography seems to be a promising approach to shape a \\emph{conventional} electron beam into a helical form with large values of angular momentum. Here, we propose and manufacture a nano-fabricated phase hologram for generating a beam of this kind with an orbital angular momentum up to 200$\\hbar$. Based on a novel technique the value of orbital angular momentum of the generated beam are measured, then compared with simulations. Our work, apart from the technological achievements, may lead to a way of generating electron beams with a high quanta of magnetic momen...
Twisting the [ital N]=2 string
Energy Technology Data Exchange (ETDEWEB)
Ketov, S.V.; Lechtenfeld, O. (Institut fuer Theoretische Physik, Universitaet Hannover, Appelstrasse 2, 30167 Hannover (Germany)); Parkes, A.J. (Department of Artificial Intelligence, 80 South Bridge, Edinburgh EH1 9HN (United Kingdom))
1995-03-15
The most general homogeneous monodromy conditions in [ital N]=2 string theory are classified in terms of the conjugacy classes of the global symmetry group U(1,1)[direct product][ital openZ][sub 2]. For classes which generate a discrete subgroup [Gamma], the corresponding target space backgrounds [ital openC][sup 1,1]/[Gamma] include half spaces, complex orbifolds, and tori. We propose a generalization of the intercept formula to matrix-valued twists, but find massless physical states only for [Gamma]=[ital open]1 (untwisted) and [Gamma]=[ital openZ][sub 2] (in the manner of Mathur and Mukhi), as well as for [Gamma] being a parabolic element of U(1,1). In particular, the 16 [ital openZ][sub 2]-twisted sectors of the [ital N]=2 string are investigated, and the corresponding ground states are identified via bosonization and BRST cohomology. We find enough room for an extended multiplet of spacetime'' supersymmetry, with the number of supersymmetries being dependent on global spacetime'' topology. However, world-sheet locality for the chiral vertex operators does not permit interactions among all massless spacetime'' fermions.
Twisting Fluorescence through Extrinsic Chiral Antennas.
Yan, Chen; Wang, Xiaolong; Raziman, T V; Martin, Olivier J F
2017-03-22
Plasmonic antennas and planar structures have been undergoing intensive developments in order to control the scattering and absorption of light. One specific class, extrinsic chiral surfaces, that does not possess 2-fold rotational symmetry exhibits strong asymmetric transmission for different circular polarizations under obliquely incident illumination. In this work, we show that the design of those surfaces can be optimized with complex multipolar resonances in order to twist the fluorescence emission from nearby molecules. While this emission is usually dipolar and linearly polarized, the interaction with these resonances twists it into a multipolar radiation pattern with opposite helicity in different directions. The proposed structure maximizes this effect and provides control over the polarization of light. Splitting of left- and right-handed circularly polarized light is experimentally obtained in the backward direction. These results highlight the intricate interplay between the near-field absorption and the far-field scattering of a plasmonic nanostructure and are further used for modifying the emission of incoherent quantum sources. Our finding can potentially lead to the development of polarization- and angle-resolved ultracompact optical devices.
Twisted geometries, twistors and conformal transformations
Långvik, Miklos
2016-01-01
The twisted geometries of spin network states are described by simple twistors, isomorphic to null twistors with a time-like direction singled out. The isomorphism depends on the Immirzi parameter, and reduces to the identity when the parameter goes to infinity. Using this twistorial representation we study the action of the conformal group SU(2,2) on the classical phase space of loop quantum gravity, described by twisted geometry. The generators of translations and conformal boosts do not preserve the geometric structure, whereas the dilatation generator does. It corresponds to a 1-parameter family of embeddings of T*SL(2,C) in twistor space, and its action preserves the intrinsic geometry while changing the extrinsic one - that is the boosts among polyhedra. We discuss the implication of this action from a dynamical point of view, and compare it with a discretisation of the dilatation generator of the continuum phase space, given by the Lie derivative of the group character. At leading order in the continuu...
How the embryonic brain tube twists
Chen, Zi; Guo, Qiaohang; Forsch, Nickolas; Taber, Larry
2014-03-01
During early development, the tubular brain of the chick embryo undergoes a combination of progressive ventral bending and rightward torsion. This deformation is one of the major organ-level symmetry-breaking events in development. Available evidence suggests that bending is caused by differential growth, but the mechanism for torsion remains poorly understood. Since the heart almost always loops in the same direction that the brain twists, researchers have speculated that heart looping affects the direction of brain torsion. However, direct evidence is virtually nonexistent, nor is the mechanical origin of such torsion understood. In our study, experimental perturbations show that the bending and torsional deformations in the brain are coupled and that the vitelline membrane applies an external load necessary for torsion to occur. In addition, the asymmetry of the looping heart gives rise to the chirality of the twisted brain. A computational model is used to interpret these findings. Our work clarifies the mechanical origins of brain torsion and the associated left-right asymmetry, reminiscent of D'Arcy Thompson's view of biological form as ``diagram of forces''.
Structure of twisted and buckled bilayer graphene
Jain, Sandeep K.; Juričić, Vladimir; Barkema, Gerard T.
2017-03-01
We study the atomic structure of twisted bilayer graphene, with very small mismatch angles (θ ∼ {0.28}0), a topic of intense recent interest. We use simulations, in which we combine a recently presented semi-empirical potential for single-layer graphene, with a new term for out-of-plane deformations, (Jain et al 2015 J. Phys. Chem. C 119 9646) and an often-used interlayer potential (Kolmogorov et al 2005 Phys. Rev. B 71 235415). This combination of potentials is computationally cheap but accurate and precise at the same time, allowing us to study very large samples, which is necessary to reach very small mismatch angles in periodic samples. By performing large scale atomistic simulations, we show that the vortices appearing in the Moiré pattern in the twisted bilayer graphene samples converge to a constant size in the thermodynamic limit. Furthermore, the well known sinusoidal behavior of energy no longer persists once the misorientation angle becomes very small (θ \\lt {1}0). We also show that there is a significant buckling after the relaxation in the samples, with the buckling height proportional to the system size. These structural properties have direct consequences on the electronic and optical properties of bilayer graphene.
Directory of Open Access Journals (Sweden)
Young H. YOU
2017-08-01
Full Text Available The best active twist schedules exploiting various waveform types are sought taking advantage of the global search algorithm for the reduction of hub vibration and/or power required of a rotor in high-speed conditions. The active twist schedules include two non-harmonic inputs formed based on segmented step functions as well as the simple harmonic waveform input. An advanced Particle Swarm assisted Genetic Algorithm (PSGA is employed for the optimizer. A rotorcraft Computational Structural Dynamics (CSD code CAMRAD II is used to perform the rotor aeromechanics analysis. A Computation Fluid Dynamics (CFD code is coupled with CSD for verification and some physical insights. The PSGA optimization results are verified against the parameter sweep study performed using the harmonic actuation. The optimum twist schedules according to the performance and/or vibration reduction strategy are obtained and their optimization gains are compared between the actuation cases. A two-phase non-harmonic actuation schedule demonstrates the best outcome in decreasing the power required while a four-phase non-harmonic schedule results in the best vibration reduction as well as the simultaneous reductions in the power required and vibration. The mechanism of reduction to the performance gains is identified illustrating the section airloads, angle-of-attack distribution, and elastic twist deformation predicted by the present approaches.
Jaiwal, Ranjana; Chaturvedi, C M
2013-01-01
Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 4 h after 5-hydroxytryptophan (5-HTP, serotonin precursor) induced inhibitory responses in recrudescing gonad (in the first week of December) of Indian palm squirrel, a seasonally breeding subtropical animal. Other temporal relations (L-DOPA given at 0, 8, 12, 16, and 20 h after 5-HTP administration) did not show any effect on the recrudescing gonad. This inhibitory effect of 4 h was evident under short day length (6 : 18) group but was masked by the increasing day length of nature (NDL, late December onwards) and increased photoperiod of long day group (16 : 8). It is apparent that seasonal testicular recrudescence of Indian palm squirrel during short day length by 4 h relation of 5-HTP and L-DOPA is not a pharmacological effect but actually is an alteration of seasonality in this annually breeding mammal. It seems that endogenous mechanism controlling seasonal testicular recrudescence of Indian palm squirrel is reset by timed daily injections of these neurotransmitter drugs. It is suggested that in spite of different environmental factors (photoperiod, humidity, etc.) used by different species to time their annual reproduction, basic mechanism of seasonality appears to be the same, that is, the temporal synergism of neurotransmitter activity.
Calderón, G D; Esquivel, Gabriela J; García, Ernestina H; Osnaya, Norma B; Juárez Olguín, H
2010-06-01
Our aim was to evaluate the effects of marijuana (Mar) and diazepam (Dz) on lipid peroxidation (TBARS), Na + , K + ATP ase activity, levels of glutathione (GSH) and 5-hydroxytryptophan (5-HTP). Male Wistar rats were given a single dose per group: extract of Mar (100 microL/kg), Dz (5 mg/kg), Mar plus Dz, and NaCl for control. Sixty mins after treatment, animals were sacrificed, and their brains extracted and homogenised to measure GSH, TBARS and 5-HTP levels. Na + , K + ATP ase and total ATP ase activities. GSH and TBARS did not show differences respect to controls. Na + , K + ATP ase activity was similar as well. However, groups treated with Mar, total ATPase activity decreased significantly (p HTP decreased significantly (p = 0.0001) in rats treated either with Mar and or Dz. Mar and Dz induced biochemical effects on the serotonergic metabolism, which can alter the development and function in rat brain, because it has also been involved in scavenging free radicals present there.
Directory of Open Access Journals (Sweden)
Hong Zhou
Full Text Available Various toxicants, drugs and their metabolites carry potential ovarian toxicity. Ovarian follicles, the functional unit of the ovary, are susceptible to this type of damage at all stages of their development. However, despite of the large scale of potential negative impacts, assays that study ovarian toxicity are limited. Exposure of cultured ovarian follicles to toxicants of interest served as an important tool for evaluation of toxic effects for decades. Mouse follicles cultured on the bottom of a culture dish continue to serve an important approach for mechanistic studies. In this paper, we demonstrated the usefulness of a hydrogel based 3-dimensional (3D mouse ovarian follicle culture as a tool to study ovarian toxicity in a different setup. The 3D in vitro culture, based on fibrin alginate interpenetrating network (FA-IPN, preserves the architecture of the ovarian follicle and physiological structure-function relationship. We applied the novel 3D high-throughput (HTP in vitro ovarian follicle culture system to study the ovotoxic effects of an anti-cancer drug, Doxorobucin (DXR. The fibrin component in the system is degraded by plasmin and appears as a clear circle around the encapsulated follicle. The degradation area of the follicle is strongly correlated with follicle survival and growth. To analyze fibrin degradation in a high throughput manner, we created a custom MATLAB® code that converts brightfield micrographs of follicles encapsulated in FA-IPN to binary images, followed by image analysis. We did not observe any significant difference between manually processed images to the automated MATLAB® method, thereby confirming that the automated program is suitable to measure fibrin degradation to evaluate follicle health. The cultured follicles were treated with DXR at concentrations ranging from 0.005 nM to 200 nM, corresponding to the therapeutic plasma levels of DXR in patients. Follicles treated with DXR demonstrated decreased
Directory of Open Access Journals (Sweden)
Lei Pan
Full Text Available BACKGROUND: Q fever is the most widespread zoonosis, and domestic animals are the most common sources of transmission. It is not only difficult to distinguish from other febrile diseases because of the lack of specific clinical manifestations in humans, but it is also difficult to identify the disease in C. burnetii-carrying animals because of the lack of identifiable features. Conventional serodiagnosis requires sera from the acute and convalescent stages of infection, which are unavailable at early diagnosis. Nested PCR and real-time PCR require equipment. In this study, we developed a Loop-Mediated Isothermal Amplification (LAMP assay to identify C. burnetii rapidly and sensitively. METHODS: A universal LAMP primer set was designed to detect the repeated sequence IS1111a of the htpAB gene of C. burnetii using PrimerExplorer V4 software. The sensitivity of the LAMP assay was evaluated using known quantities of recombined reference plasmids containing the targeted genes. The specificity of the developed LAMP assay was determined using 26 members of order Rickettsiae and 18 other common pathogens. The utility of the LAMP assay was further compared with real time PCR by the examination 24 blood samples including 6 confirmed and 18 probable Q fever cases, which diagnosed by IFA serological assessment and real time PCR. In addition, 126 animal samples from 4 provinces including 97 goats, 7 cattle, 18 horses, 3 marmots and 1 deer were compared by these two methods. RESULTS: The limits of detection of the LAMP assay for the htpAB gene were 1 copy per reaction. The specificity of the LAMP assay was 100%, and no cross-reaction was observed among the bacteria used in the study. The positive rate of unknown febrile patients was 33.3%(95%CI 30.2%-36.4% for the LAMP assay and 8.3%(95%CI 7.4%-9.2% for the real time PCR(P<0.05. Similarly, the total positive rate of animals was 7.9%(95%CI 7.1%-8.7% for the LAMP assay and 0.8%(95%CI 0.7%-0.9%for the real time
Zhou, Hong; Malik, Malika Amattullah; Arab, Aarthi; Hill, Matthew Thomas; Shikanov, Ariella
2015-01-01
Various toxicants, drugs and their metabolites carry potential ovarian toxicity. Ovarian follicles, the functional unit of the ovary, are susceptible to this type of damage at all stages of their development. However, despite of the large scale of potential negative impacts, assays that study ovarian toxicity are limited. Exposure of cultured ovarian follicles to toxicants of interest served as an important tool for evaluation of toxic effects for decades. Mouse follicles cultured on the bottom of a culture dish continue to serve an important approach for mechanistic studies. In this paper, we demonstrated the usefulness of a hydrogel based 3-dimensional (3D) mouse ovarian follicle culture as a tool to study ovarian toxicity in a different setup. The 3D in vitro culture, based on fibrin alginate interpenetrating network (FA-IPN), preserves the architecture of the ovarian follicle and physiological structure-function relationship. We applied the novel 3D high-throughput (HTP) in vitro ovarian follicle culture system to study the ovotoxic effects of an anti-cancer drug, Doxorobucin (DXR). The fibrin component in the system is degraded by plasmin and appears as a clear circle around the encapsulated follicle. The degradation area of the follicle is strongly correlated with follicle survival and growth. To analyze fibrin degradation in a high throughput manner, we created a custom MATLAB® code that converts brightfield micrographs of follicles encapsulated in FA-IPN to binary images, followed by image analysis. We did not observe any significant difference between manually processed images to the automated MATLAB® method, thereby confirming that the automated program is suitable to measure fibrin degradation to evaluate follicle health. The cultured follicles were treated with DXR at concentrations ranging from 0.005 nM to 200 nM, corresponding to the therapeutic plasma levels of DXR in patients. Follicles treated with DXR demonstrated decreased survival rate in
Cellularity of diagram algebras as twisted semigroup algebras
Wilcox, Stewart
2010-01-01
The Temperley-Lieb and Brauer algebras and their cyclotomic analogues, as well as the partition algebra, are all examples of twisted semigroup algebras. We prove a general theorem about the cellularity of twisted semigroup algebras of regular semigroups. This theorem, which generalises a recent result of East about semigroup algebras of inverse semigroups, allows us to easily reproduce the cellularity of these algebras.
Behaviour at infinity of solutions of twisted convolution equations
Energy Technology Data Exchange (ETDEWEB)
Volchkov, Valerii V; Volchkov, Vitaly V [Donetsk National University, Donetsk (Ukraine)
2012-02-28
We obtain a precise characterization of the minimal rate of growth at infinity of non-trivial solutions of twisted convolution equations in unbounded domains of C{sup n}. As an application, we obtain definitive versions of the two-radii theorem for twisted spherical means.
Quadratic Twists of Rigid Calabi–Yau Threefolds Over
DEFF Research Database (Denmark)
Gouvêa, Fernando Q.; Kiming, Ian; Yui, Noriko
2013-01-01
We consider rigid Calabi–Yau threefolds defined over Q and the question of whether they admit quadratic twists. We give a precise geometric definition of the notion of a quadratic twists in this setting. Every rigid Calabi–Yau threefold over Q is modular so there is attached to it a certain newfo...
Design optimization of a twist compliant mechanism with nonlinear stiffness
Tummala, Y.; Frecker, M. I.; Wissa, A. A.; Hubbard, J. E., Jr.
2014-10-01
A contact-aided compliant mechanism called a twist compliant mechanism (TCM) is presented in this paper. This mechanism has nonlinear stiffness when it is twisted in both directions along its axis. The inner core of the mechanism is primarily responsible for its flexibility in one twisting direction. The contact surfaces of the cross-members and compliant sectors are primarily responsible for its high stiffness in the opposite direction. A desired twist angle in a given direction can be achieved by tailoring the stiffness of a TCM. The stiffness of a compliant twist mechanism can be tailored by varying thickness of its cross-members, thickness of the core and thickness of its sectors. A multi-objective optimization problem with three objective functions is proposed in this paper, and used to design an optimal TCM with desired twist angle. The objective functions are to minimize the mass and maximum von-Mises stress observed, while minimizing or maximizing the twist angles under specific loading conditions. The multi-objective optimization problem proposed in this paper is solved for an ornithopter flight research platform as a case study, with the goal of using the TCM to achieve passive twisting of the wing during upstroke, while keeping the wing fully extended and rigid during the downstroke. Prototype TCMs have been fabricated using 3D printing and tested. Testing results are also presented in this paper.
Twisted tubular photobioreactor fluid dynamics evaluation for energy consumption minimization
Gómez-Pérez, C.A.; Espinosa Oviedo, J.J.; Montenegro Ruiz, L.C.; Boxtel, van A.J.B.
2017-01-01
This paper discusses a new tubular PhotoBioReactor (PBR) called twisted tubular PBR. The geometry of a twisted tubular PBR induces swirl mixing to guarantee good exposure of microalgae to Light-Dark (LD) cycles and to the nutrients and dissolved CO 2 . The paper analyses the energy uptake for fluid
Resonances and higher twist in polarized lepton-nucleon scattering
Edelmann, J; Kaiser, N; Weise, W
2000-01-01
We present a detailed analysis of resonance contributions in the context of higher twist effects in the moments of the proton spin structure function g_1. For each of these moments, it is found that there exists a characteristic Q^2 region in which (perturbative) higher twist corrections coexist with (non-perturbative) resonance contribution of comparable magnitude.
Effect of pump depletion and cross-focusing on twisted terahertz radiation generation
Sobhani, Hassan; Dehghan, Mehdi; Dadar, Elham
2017-02-01
In this paper, the pump depletion and cross-focusing effects on the generation of twisted terahertz radiation are investigated. Based on the beating of two Laguerre-Gaussian lasers in a radial plasma channel, a twisted terahertz radiation can be produced. In the presence of pump depletion, the lasers power is consumed. So, the ponderomotive force nonlinearity decreases and the output terahertz field approaches to a saturation value. Under competition between the diffraction and nonlinearity effects, the amplitude of laser beam width oscillation grows. When the incident laser beams have non-similar topological charge numbers, the normalized generated terahertz amplitude is low and the pump depletion effect on the laser beam width evolution is ignorable.
Twisted Fock representations of noncommutative Kähler manifolds
Sako, Akifumi; Umetsu, Hiroshi
2016-09-01
We introduce twisted Fock representations of noncommutative Kähler manifolds and give their explicit expressions. The twisted Fock representation is a representation of the Heisenberg like algebra whose states are constructed by applying creation operators to a vacuum state. "Twisted" means that creation operators are not Hermitian conjugate of annihilation operators in this representation. In deformation quantization of Kähler manifolds with separation of variables formulated by Karabegov, local complex coordinates and partial derivatives of the Kähler potential with respect to coordinates satisfy the commutation relations between the creation and annihilation operators. Based on these relations, we construct the twisted Fock representation of noncommutative Kähler manifolds and give a dictionary to translate between the twisted Fock representations and functions on noncommutative Kähler manifolds concretely.
Landau damping of Langmuir twisted waves with kappa distributed electrons
Energy Technology Data Exchange (ETDEWEB)
Arshad, Kashif, E-mail: kashif.arshad.butt@gmail.com; Aman-ur-Rehman [Pakistan Institute of Engineering and Applied Sciences, P. O. Nilore, Islamabad 45650 (Pakistan); Mahmood, Shahzad [Pakistan Institute of Engineering and Applied Sciences, P. O. Nilore, Islamabad 45650 (Pakistan); Theoretical Physics Division, PINSTECH, P.O. Nilore, Islamabad 44000 (Pakistan)
2015-11-15
The kinetic theory of Landau damping of Langmuir twisted modes is investigated in the presence of orbital angular momentum of the helical (twisted) electric field in plasmas with kappa distributed electrons. The perturbed distribution function and helical electric field are considered to be decomposed by Laguerre-Gaussian mode function defined in cylindrical geometry. The Vlasov-Poisson equation is obtained and solved analytically to obtain the weak damping rates of the Langmuir twisted waves in a nonthermal plasma. The strong damping effects of the Langmuir twisted waves at wavelengths approaching Debye length are also obtained by using an exact numerical method and are illustrated graphically. The damping rates of the planar Langmuir waves are found to be larger than the twisted Langmuir waves in plasmas which shows opposite behavior as depicted in Fig. 3 by J. T. Mendoça [Phys. Plasmas 19, 112113 (2012)].
Analysis list: Twist1 [Chip-atlas[Archive
Lifescience Database Archive (English)
Full Text Available Twist1 Embryo,Neural + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Tw...ist1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Twist1.5.tsv http://dbarchive.biosciencedbc....jp/kyushu-u/mm9/target/Twist1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Twist1.Embryo.tsv,http://dbarchive.bioscien...cedbc.jp/kyushu-u/mm9/colo/Twist1.Neural.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Neural.gml ...
Twisted Fock Representations of Noncommutative K\\"ahler Manifolds
Sako, Akifumi
2016-01-01
We introduce twisted Fock representations of noncommutative K\\"ahler manifolds and give their explicit expressions. The twisted Fock representation is a representation of the Heisenberg like algebra whose states are constructed by acting creation operators on a vacuum state. "Twisted" means that creation operators are not hermitian conjugate of annihilation operators in this representation. In deformation quantization of K\\"ahler manifolds with separation of variables formulated by Karabegov, local complex coordinates and partial derivatives of the K\\"ahler potential with respect to coordinates satisfy the commutation relations between the creation and annihilation operators. Based on these relations, we construct the twisted Fock representation of noncommutative K\\"ahler manifolds and give a dictionary to translate between the twisted Fock representations and functions on noncommutative K\\"ahler manifolds concretely.
Twist1 activity thresholds define multiple functions in limb development.
Krawchuk, Dayana; Weiner, Shoshana J; Chen, You-Tzung; Lu, Benson C; Costantini, Frank; Behringer, Richard R; Laufer, Ed
2010-11-01
The basic helix-loop-helix transcription factor Twist1 is essential for normal limb development. Twist1(-/-) embryos die at midgestation. However, studies on early limb buds found that Twist1(-/-) mutant limb mesenchyme has an impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loop between the mesenchyme and AER, and reduces and shifts anteriorly Shh expression in the zone of polarizing activity. We have combined Twist1 null, hypomorph and conditional alleles to generate a Twist1 allelic series that survives to birth. As Twist1 activity is reduced, limb skeletal defects progress from preaxial polydactyly to girdle reduction combined with hypoplasia, aplasia or mirror symmetry of all limb segments. With reduced Twist1 activity there is striking and progressive upregulation of ectopic Shh expression in the anterior of the limb, combined with an anterior shift in the posterior Shh domain, which is expressed at normal intensity, and loss of the posterior AER. Consequently limb outgrowth is initially impaired, before an ectopic anterior Shh domain expands the AER, promoting additional growth and repatterning. Reducing the dosage of FGF targets of the Etv gene family, which are known repressors of Shh expression in anterior limb mesenchyme, strongly enhances the anterior skeletal phenotype. Conversely this and other phenotypes are suppressed by reducing the dosage of the Twist1 antagonist Hand2. Our data support a model whereby multiple Twist1 activity thresholds contribute to early limb bud patterning, and suggest how particular combinations of skeletal defects result from differing amounts of Twist1 activity.
Do twisted laser beams evoke nuclear hyperpolarization?
Schmidt, A. B.; Andrews, D. L.; Rohrbach, A.; Gohn-Kreuz, C.; Shatokhin, V. N.; Kiselev, V. G.; Hennig, J.; von Elverfeldt, D.; Hövener, J.-B.
2016-07-01
The hyperpolarization of nuclear spins promises great advances in chemical analysis and medical diagnosis by substantially increasing the sensitivity of nuclear magnetic resonance (NMR). Current methods to produce a hyperpolarized sample, however, are arduous, time-consuming or costly and require elaborate equipment. Recently, a much simpler approach was introduced that holds the potential, if harnessed appropriately, to revolutionize the production of hyperpolarized spins. It was reported that high levels of hyperpolarization in nuclear spins can be created by irradiation with a laser beam carrying orbital angular momentum (twisted light). Aside from these initial reports however, no further experimental verification has been presented. In addition, this effect has so far evaded a critical theoretical examination. In this contribution, we present the first independent attempt to reproduce the effect. We exposed a sample of immersion oil or a fluorocarbon liquid that was placed within a low-field NMR spectrometer to Laguerre-Gaussian and Bessel laser beams at a wavelength of 514.5 nm and various topological charges. We acquired 1H and 19F NMR free induction decay data, either during or alternating with the irradiation that was parallel to B0. We observed an irregular increase in NMR signal in experiments where the sample was exposed to beams with higher values of the topological charge. However, at no time did the effect reach statistical significance of 95%. Given the measured sensitivity of our setup, we estimate that a possible effect did not exceed a hyperpolarization (at 5 mT) of 0.14-6%, depending on the assumed hyperpolarized volume. It should be noted though, that there were some differences between our setup and the previous implementation of the experiment, which may have inhibited the full incidence of this effect. To approach a theoretical description of this effect, we considered the interaction of an electron with a plane wave, which is known to be
Fachinelli, C; Sargo, S; Bataller, R; Rodríguez Echandía, E L
1989-12-01
There is abundant literature about the effects of manipulation of 5-hydroxytryptamine (5-HT) systems on some killer behaviors as well as on social isolation and shock-induced aggression in rodents. In this work we have analyzed the effect of 5-HT manipulation on the aggressive behavior induced by food competition in undernourished pigeons. Adult males (n = 12) were caged individually and their body weight kept at 80-85% by a restricted diet. These were divided in pairs which were exposed daily to an aggressive interaction test (20 min) in a 1.5 x 1.5 x 2.0 m chamber bearing a central feeding device. Once consolidation of dominance was obtained in each pair, the dominant and the submissive members were injected subcutaneously, on alternating days, with 5-hydroxytryptophan (5-HTP) (7.5, 15 and 30 mg/kg), ketanserine (20 and 30 mg/kg) and a combination of ketanserine (20 mg/kg) and 5-HTP (7.5 mg/kg). Aggression was evaluated by scoring the frequency and time spent biting, wing beating, aggressive following and vocalizations, threatening and pushing the opponent in 20-min tests. The time spent running away was also scored. Intratest feeding was ascertained by weighing the subjects immediately before and after testing. The scores were compared with those obtained after saline injection on the preceding day (C-scores). 5-HTP (7.5 mg/kg) attenuated aggression without affecting feeding in dominant members, and decreased the time spent running away by submissives. Higher doses of 5-HTP decreased feeding but did not potentiate the anti-aggressive effects. The 5-HT2 antagonist, ketanserine did not affect aggression but decreased feeding at the dose of 30 mg/kg. Ketanserine injection clearly prevented the anti-aggressive effects of 5-HTP but caused a decrease of feeding. Results show that 5-HT stimulation in pigeons can preferentially block aggression in this particular experimental situation. It is suggested, in addition, that 5-HT2 receptors might be involved in such an
Dais, Jennifer; Khosia, Ankur; Doulatram, Gulshan
2015-01-01
Instituting drug holidays for chronic opioid using patients is becoming commonplace for pain practitioners initiating procedures such as intrathecal pump or spinal cord stimulator trials. As such, pain practitioners need to be adept in their management of acute opioid withdrawal. Successfully weaning an opioid dependent patient off of chronic opioids requires a thorough knowledge of the available adjuvants to assist in this process. However, that selection can become exhausted by adjuvant side effects or by ineffective attenuation of opioid withdrawal symptoms. In that case, novel drugs, or novel application of currently available medications must be sought after to assist in the drug holiday. We present a case in which refractory muscle spasms secondary to opioid withdrawal were successfully treated with an over-the-counter supplement that is not typically used for the attenuation of opioid withdrawal symptoms. In a patient intolerant to the side effects of clonidine, we were able to successfully wean chronic opiates by treating refractory muscle spasms with the serotonin precursor, 5-hydroxytryptophan (5-HTP). We hypothesize that our success with this medication gives further credence to the role of serotonin in opioid withdrawal somatic symptomatology, and supports the need for future research to clarify the role of serotonin precursors or serotonin modulating drugs as potential alternatives in those unable to follow standard treatment protocols.
Twist-joints and double twist-joints in RNA structure.
Boutorine, Yury I; Steinberg, Sergey V
2012-12-01
Analysis of available RNA crystal structures has allowed us to identify a new family of RNA arrangements that we call double twist-joints, or DTJs. Each DTJ is composed of a double helix that contains two bulges incorporated into different strands and separated from each other by 2 or 3 bp. At each bulge, the double helix is over-twisted, while the unpaired nucleotides of both bulges form a complex network of stacking and hydrogen-bonding with nucleotides of helical regions. In total, we identified 14 DTJ cases, which can be combined in three groups based on common structural characteristics. One DTJ is found in a functional center of the ribosome, another DTJ mediates binding of the pre-tRNA to the RNase P, and two more DTJs form the sensing domains in the glycine riboswitch.
Optical Twist Induced by Plasmonic Resonance
Chen, Jun; Wang, Neng; Cui, Liyong; Li, Xiao; Lin, Zhifang; Ng, Jack
2016-06-01
Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutual scattering or light exchange to exhibit a conspicuously enhanced optical torque without large extinction or absorption cross section. The torque on each object is almost equal but opposite, which we called optical twist. The effect is quite significant for plasmonic particle cluster, but can also be observed in structures with other morphologies. Such approach exhibits an unprecedentedly large torque to light extinction or absorption ratio, enabling limited light to exert a relatively large torque without severe heating. Our work contributes to the understanding of optical torque and introduces a novel way to manipulate the internal degrees of freedom of a structured particle cluster.
Twisted Light Transmission over 143 kilometers
Krenn, Mario; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton
2016-01-01
Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, while free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here we show the transmission of orbital angular momentum modes of light over a distance of 143 kilometers between two Canary Islands, which is 50 times greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order, and decode the transmitted message with an error rate of 8.33%....
Twisted Polynomials and Forgery Attacks on GCM
DEFF Research Database (Denmark)
Abdelraheem, Mohamed Ahmed A. M. A.; Beelen, Peter; Bogdanov, Andrey;
2015-01-01
nonce misuse resistance, such as POET. The algebraic structure of polynomial hashing has given rise to security concerns: At CRYPTO 2008, Handschuh and Preneel describe key recovery attacks, and at FSE 2013, Procter and Cid provide a comprehensive framework for forgery attacks. Both approaches rely...... heavily on the ability to construct forgery polynomials having disjoint sets of roots, with many roots (“weak keys”) each. Constructing such polynomials beyond naïve approaches is crucial for these attacks, but still an open problem. In this paper, we comprehensively address this issue. We propose to use...... in an improved key recovery algorithm. As cryptanalytic applications of our twisted polynomials, we develop the first universal forgery attacks on GCM in the weak-key model that do not require nonce reuse. Moreover, we present universal weak-key forgeries for the nonce-misuse resistant AE scheme POET, which...
Obregón, O; Ryan, M P; Obregon, Octavio; Quevedo, Hernando; Ryan, Michael P.
2004-01-01
We construct a family of time and angular dependent, regular S-brane solutions which corresponds to a simple analytical continuation of the Zipoy-Voorhees 4-dimensional vacuum spacetime. The solutions are asymptotically flat and turn out to be free of singularities without requiring a twist in space. They can be considered as the simplest non-singular generalization of the singular S0-brane solution. We analyze the properties of a representative of this family of solutions and show that it resembles to some extent the asymptotic properties of the regular Kerr S-brane. The R-symmetry corresponds, however, to the general Lorentzian symmetry. Several generalizations of this regular solution are derived which include a charged S-brane and an additional dilatonic field.
A Solvable Twisted One-Plaquette Model
Billó, M.; D'Adda, A.
We solve a hot twisted Eguchi-Kawai model with only timelike plaquettes in the deconfined phase, by computing the quadratic quantum fluctuations around the classical vacuum. The solution of the model has some novel features: the eigenvalues of the timelike link variable are separated in L bunches, if L is the number of links of the original lattice in the time direction, and each bunch obeys a Wigner semicircular distribution of eigenvalues. This solution becomes unstable at a critical value of the coupling constant, where it is argued that a condensation of classical solutions takes place. This can be inferred by comparison with the heat-kernel model in the Hamiltonian limit, and the related Douglas-Kazakov phase transition in QCD2. As a byproduct of our solution, we can reproduce the dependence of the coupling constant from the parameter describing the asymmetry of the lattice, and compare it to previous results by Karsch.
Twisted and Nontwisted Bifurcations Induced by Diffusion
Lin, X B
1996-01-01
We discuss a diffusively perturbed predator-prey system. Freedman and Wolkowicz showed that the corresponding ODE can have a periodic solution that bifurcates from a homoclinic loop. When the diffusion coefficients are large, this solution represents a stable, spatially homogeneous time-periodic solution of the PDE. We show that when the diffusion coefficients become small, the spatially homogeneous periodic solution becomes unstable and bifurcates into spatially nonhomogeneous periodic solutions. The nature of the bifurcation is determined by the twistedness of an equilibrium/homoclinic bifurcation that occurs as the diffusion coefficients decrease. In the nontwisted case two spatially nonhomogeneous simple periodic solutions of equal period are generated, while in the twisted case a unique spatially nonhomogeneous double periodic solution is generated through period-doubling. Key Words: Reaction-diffusion equations; predator-prey systems; homoclinic bifurcations; periodic solutions.
Energy release in driven twisted coronal loops
Bareford, M R; Browning, P K; Hood, A W
2015-01-01
In the present study we investigate magnetic reconnection in twisted magnetic fluxtubes with different initial configurations. In all considered cases, energy release is triggered by the ideal kink instability, which is itself the result of applying footpoint rotation to an initially potential field. The main goal of this work is to establish the influence of the field topology and various thermodynamic effects on the energy release process. Specifically, we investigate convergence of the magnetic field at the loop footpoints, atmospheric stratification, as well as thermal conduction. In all cases, the application of vortical driving at the footpoints of an initally potential field leads to an internal kink instability. With the exception of the curved loop with high footpoint convergence, the global geometry of the loop change little during the simulation. Footpoint convergence, curvature and atmospheric structure clearly influences the rapidity with which a loop achieves instability as well as the size of t...
Twisted accretion discs: Pt. 5; Viscous evolution
Energy Technology Data Exchange (ETDEWEB)
Kumar, S. (Max-Planck-Institut fuer Physik und Astrophysik, Garching (Germany, F.R.). Inst. fuer Astrophysik)
1990-08-15
The time-dependence of accretion discs with orbits tilted out of the symmetry plane is studied. The effects of mass inflow modulation, and tilt variation at the disc outer edge, are examined for both circumbinary discs and for discs around compact objects. The appendices extend the numerical work to some analytic examples of tilt diffusion and external forcing effects. It is also shown that the disc must not be treated as a rigid tilted object if global angular momentum is to be conserved. These results are relevant to the problem of long-term periodicities of the light curves in Her X1 and {epsilon} Aur, the S-type symmetry of radio jets, warped gas discs in galaxies and polar rings in Neptune. Twisted discs may also arise in star-forming regions. (author).
Optical twists in phase and amplitude
DEFF Research Database (Denmark)
Daria, Vincent R.; Palima, Darwin; Glückstad, Jesper
2011-01-01
beams, the far field projection of the twisted optical beam maintains a high photon concentration even at higher values of topological charge. Optical twisters have therefore profound applications to fundamental studies of light and atoms such as in quantum entanglement of the OAM, toroidal traps......Light beams with helical phase profile correspond to photons having orbital angular momentum (OAM). A Laguerre-Gaussian (LG) beam is an example where its helical phase sets a phase-singularity at the optical axis and forms a ring-shaped transverse amplitude profile. Here, we describe a unique beam...... where both phase and amplitude express a helical profile as the beam propagates in free space. Such a beam can be accurately referred to as an optical twister. We characterize optical twisters and demonstrate their capacity to induce spiral motion on particles trapped along the twisters’ path. Unlike LG...
Twisted Black Hole Is Taub-NUT
Ong, Yen Chin
2016-01-01
Recently a purportedly novel solution of the vacuum Einstein field equations was discovered: it supposedly describes an asymptotically flat twisted black hole in 4-dimensions whose exterior spacetime rotates in a peculiar manner -- the frame dragging in the northern hemisphere is opposite from that of the southern hemisphere, which results in a globally vanishing angular momentum. Furthermore it was shown that the spacetime has no curvature singularity. We show that the geometry of this black hole spacetime is nevertheless not free of pathological features. In particular, it harbors a rather drastic conical singularity along the axis of rotation. In addition, there exist closed timelike curves due to the fact that the constant r and constant t surfaces are not globally Riemannian. In fact, none of these are that surprising since the solution is just the Taub-NUT geometry.
Unusual presentation of twisted ovarian cyst
Directory of Open Access Journals (Sweden)
Vineet V Mishra
2016-01-01
Full Text Available Ovarian torsion (also termed as adnexal torsion refers to partial or complete rotation of the ovary and a portion of fallopian tube along its supplying vascular pedicle. It occurs commonly in reproductive age group; more on the right side (60% and often presents with acute lower abdominal pain lasting for few hours and up to 24 h, accounting for 2.7% of acute gynecological conditions. It is one of the devastating conditions, hampering blood supply of ovary which may lead to total necrosis of ovarian tissue and complications, if not diagnosed and managed in time. Hence, we present a case on a twisted ovarian cyst in postmenopausal woman with unusual symptomatology leading to delayed diagnosis and loss of an ovary.
Twisted boundary states in c=1 coset conformal field theories
Ishikawa, H; Ishikawa, Hiroshi; Yamaguchi, Atsushi
2003-01-01
We study the mutual consistency of twisted boundary conditions in the coset conformal field theory G/H. We calculate the overlap of the twisted boundary states of G/H with the untwisted ones, and show that the twisted boundary states are consistently defined in the diagonal modular invariant. The overlap of the twisted boundary states is expressed by the branching functions of a twisted affine Lie algebra. As a check of our argument, we study the diagonal coset theory so(2n)_1 \\oplus so(2n)_1/so(2n)_2, which is equivalent with the orbifold S^1/\\Z_2. We construct the boundary states twisted by the automorphisms of the unextended Dynkin diagram of so(2n), and show their mutual consistency by identifying their counterpart in the orbifold. For the triality of so(8), the twisted states of the coset theory correspond to neither the Neumann nor the Dirichlet boundary states of the orbifold and yield the conformal boundary states that preserve only the Virasoro algebra.
Heat Transfers Enhancement with Different Square Jagged Twisted Tapes
Directory of Open Access Journals (Sweden)
Mr. A.V.Gawandare
2014-03-01
Full Text Available The present experimental work are carried out with copper twisted tape inserts 3mm with 5.2,4.2 and 3.2 twists respectively. The inserts when placed in the path of the flow of the fluid, create a high degree of turbulence resulting in an increase in the heat transfer rate and the pressure drop. The work includes the determination of friction factor and heat transfer coefficient for various twisted wire inserts with varying twists and different materials. The Reynolds number is varied from 5000 to 16000. Correlations for Nusselt number and friction factor are developed for the twisted wire inserts from the obtained results. The results of varying twists in square jagged tape with different pitches have been compared with the values for the smooth tube. The 3mm thick with 3.2 twists copper insert shows increase in Nusselt number values by 76% however there is increase in friction factor by only 19.5% as compared to the smooth tube values.
Sun, Tong; Fu, Junjiang; Shen, Tao; Lin, Xia; Liao, Lan; Feng, Xin-Hua; Xu, Jianming
2016-05-27
Twist1 is a basic helix-loop-helix transcription factor that strongly promotes epithelial-to-mesenchymal transition, migration, invasion, and metastasis of cancer cells. The MAPK-phosphorylated Twist1 on its serine 68 (Ser(P)(68)-Twist1) has a significantly enhanced stability and function to drive cancer cell invasion and metastasis. However, the phosphatase that dephosphorylates Ser(P)(68)-Twist1 and destabilizes Twist1 has not been identified and characterized. In this study, we screened a serine/threonine phosphatase cDNA expression library in HEK293T cells with ectopically coexpressed Twist1. We found that the small C-terminal domain phosphatase 1 (SCP1) specifically dephosphorylates Ser(P)(68)-Twist1 in both cell-free reactions and living cells. SCP1 uses its amino acid residues 43-63 to interact with the N terminus of Twist1. Increased SCP1 expression in cells decreased Ser(P)(68)-Twist1 and total Twist1 proteins, whereas knockdown of SCP1 increased Ser(P)(68)-Twist1 and total Twist1 proteins. Furthermore, the levels of SCP1 are negatively correlated with Twist1 protein levels in several cancer cell lines. SCP1-dephosphorylated Twist1 undergoes fast degradation via the ubiquitin-proteasome pathway. Importantly, an increase in SCP1 expression in breast cancer cells with either endogenous or ectopically expressed Twist1 largely inhibits the Twist1-induced epithelial-to-mesenchymal transition phenotype and the migration and invasion capabilities of these cells. These results indicate that SCP1 is the phosphatase that counterregulates the MAPK-mediated phosphorylation of Ser(68)-Twist1. Thus, an increase in SCP1 expression and activity may be a useful strategy for eliminating the detrimental roles of Twist1 in cancer cells.
Tri-bimaximal mixing from twisted Friedberg-Lee symmetry
Energy Technology Data Exchange (ETDEWEB)
Araki, Takeshi [National Tsing Hua University, Department of Physics, Hsinchu (China); Takahashi, Ryo [Osaka University, Department of Physics, Graduate School of Science, Osaka (Japan)
2009-10-15
We investigate the Friedberg-Lee (FL) symmetry and its promotion to include the {mu}-{tau} symmetry, and call this the twisted FL symmetry. Based on the twisted FL symmetry, two possible schemes are presented toward the realistic neutrino mass spectrum and the tri-bimaximal mixing. In the first scheme, we suggest the semi-uniform translation of the FL symmetry. The second one is based on the S{sub 3} permutation family symmetry. The breaking terms, which are twisted FL symmetric, are introduced. Some viable models in each scheme are also presented. (orig.)
Tri-bimaximal mixing from twisted Friedberg-Lee symmetry
Araki, Takeshi; Takahashi, Ryo
2009-10-01
We investigate the Friedberg-Lee (FL) symmetry and its promotion to include the μ- τ symmetry, and call this the twisted FL symmetry. Based on the twisted FL symmetry, two possible schemes are presented toward the realistic neutrino mass spectrum and the tri-bimaximal mixing. In the first scheme, we suggest the semi-uniform translation of the FL symmetry. The second one is based on the S 3 permutation family symmetry. The breaking terms, which are twisted FL symmetric, are introduced. Some viable models in each scheme are also presented.
Assembly and Folding of Twisted Baskets in Organic Solvents.
Pratumyot, Yaowalak; Chen, Shigui; Hu, Lei; Polen, Shane M; Hadad, Christopher M; Badjić, Jovica D
2016-09-02
A synthetic method for obtaining enantiopure and twisted baskets of type (P)-3 is described. These chiral cavitands were found to fold quinoline gates, at the rim of their twisted platform, in acetonitrile and give molecular capsules that assemble into large unilamellar vesicles. In a less polar dichloromethane, however, cup-shaped (P)-3 packed into vesicles but with the quinoline gates in an unfolded orientation. The ability of twisted baskets to form functional nanostructured materials could be of interest for building stereoselective sensors and catalysts.
TWIST1 promotes invasion through mesenchymal change in human glioblastoma
Directory of Open Access Journals (Sweden)
Wakimoto Hiroaki
2010-07-01
Full Text Available Abstract Background Tumor cell invasion into adjacent normal brain is a mesenchymal feature of GBM and a major factor contributing to their dismal outcomes. Therefore, better understandings of mechanisms that promote mesenchymal change in GBM are of great clinical importance to address invasion. We previously showed that the bHLH transcription factor TWIST1 which orchestrates carcinoma metastasis through an epithelial mesenchymal transition (EMT is upregulated in GBM and promotes invasion of the SF767 GBM cell line in vitro. Results To further define TWIST1 functions in GBM we tested the impact of TWIST1 over-expression on invasion in vivo and its impact on gene expression. We found that TWIST1 significantly increased SNB19 and T98G cell line invasion in orthotopic xenotransplants and increased expression of genes in functional categories associated with adhesion, extracellular matrix proteins, cell motility and locomotion, cell migration and actin cytoskeleton organization. Consistent with this TWIST1 reduced cell aggregation, promoted actin cytoskeletal re-organization and enhanced migration and adhesion to fibronectin substrates. Individual genes upregulated by TWIST1 known to promote EMT and/or GBM invasion included SNAI2, MMP2, HGF, FAP and FN1. Distinct from carcinoma EMT, TWIST1 did not generate an E- to N-cadherin "switch" in GBM cell lines. The clinical relevance of putative TWIST target genes SNAI2 and fibroblast activation protein alpha (FAP identified in vitro was confirmed by their highly correlated expression with TWIST1 in 39 human tumors. The potential therapeutic importance of inhibiting TWIST1 was also shown through a decrease in cell invasion in vitro and growth of GBM stem cells. Conclusions Together these studies demonstrated that TWIST1 enhances GBM invasion in concert with mesenchymal change not involving the canonical cadherin switch of carcinoma EMT. Given the recent recognition that mesenchymal change in GBMs is
Topological duality twist and brane instantons in F-theory
Energy Technology Data Exchange (ETDEWEB)
Martucci, Luca [Dipartimento di Fisica ed Astronomia “Galileo Galilei”, Università di Padova andINFN - Sezione di Padova,Via Marzolo 8, I-35131 Padova (Italy)
2014-06-30
A variant of the topological twist, involving SL(2,ℤ) dualities and hence named topological duality twist, is introduced and explicitly applied to describe a U(1) N=4 super Yang-Mills theory on a Kähler space with holomorphically space-dependent coupling. Three-dimensional duality walls and two-dimensional chiral theories naturally enter the formulation of the duality twisted theory. Appropriately generalized, this theory is relevant for the study of Euclidean D3-brane instantons in F-theory compactifications. Some of its properties and implications are discussed.
Twist Neutrality and the Diameter of the Nucleosome Core Particle
DEFF Research Database (Denmark)
Bohr, Jakob; Olsen, Kasper
2012-01-01
The diameter of the nucleosome core particle is the same for all the eukaryotes. Here we discuss the possibility that this selectiveness is consistent with a propensity for twist neutrality, in particular, for the double helical DNA to stay rotationally neutral when strained. Reorganization of DNA...... cannot be done without some level of temporal tensile stress, and as a consequence chiral molecules, such as helices, will twist under strain. The requirement that the nucleosome, constituting the nucleosome core particle and linker DNA, has a vanishing strain-twist coupling leads to a requirement...
Differential forms and {kappa}-Minkowski spacetime from extended twist
Energy Technology Data Exchange (ETDEWEB)
Juric, Tajron; Meljanac, Stjepan [Rudjer Boskovic Institute, Zagreb (Croatia); Strajn, Rina [Jacobs University Bremen, Bremen (Germany)
2013-07-15
We analyze bicovariant differential calculus on {kappa}-Minkowski spacetime. It is shown that corresponding Lorentz generators and noncommutative coordinates compatible with bicovariant calculus cannot be realized in terms of commutative coordinates and momenta. Furthermore, {kappa}-Minkowski space and NC forms are constructed by twist related to a bicrossproduct basis. It is pointed out that the consistency condition is not satisfied. We present the construction of {kappa}-deformed coordinates and forms (super-Heisenberg algebra) using extended twist. It is compatible with bicovariant differential calculus with {kappa}-deformed igl(4)-Hopf algebra. The extended twist leading to {kappa}-Poincare-Hopf algebra is also discussed. (orig.)
Testing mixed action approaches to meson spectroscopy with twisted mass sea quarks
Berlin, Joshua; Wagner, Marc
2013-01-01
We explore and compare three mixed action setups with Wilson twisted mass sea quarks and different valence quark actions: (1) Wilson twisted mass, (2) Wilson twisted mass + clover and (3) Wilson + clover. Our main goal is to reduce lattice discretization errors in mesonic spectral quantities, in particular to reduce twisted mass parity and isospin breaking.
Directory of Open Access Journals (Sweden)
Laurent Jacqueroud
2016-05-01
Full Text Available The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis and their consequent neoplastic transformation. Additionally, it promotes the epithelial-to-mesenchymal transition and the initiation of the metastatic spread of cancer cells. Interestingly, cancer cells recurrently remain dependent on TWIST1 for their survival and/or proliferation, making TWIST1 their Achilles’ heel. TWIST1 has been reported to form either homodimeric or heterodimeric complexes mainly in association with the E bHLH class I proteins. These complexes display distinct, sometimes even antagonistic, functions during development and unequal prometastatic functions in prostate cancer cells. Using a tethered dimer strategy, we successively assessed the ability of TWIST1 dimers to cooperate with an activated version of RAS in human mammary epithelial cell transformation, to provide mice with the ability to spontaneously develop breast tumors, and lastly to maintain a senescence program at a latent state in several breast cancer cell lines. We demonstrate that the TWIST1-E12 complex, unlike the homodimer, is an oncogenic form of TWIST1 in mammary epithelial cells and that efficient binding of both partners is a prerequisite for its activity. The detection of the heterodimer in human premalignant lesions by a proximity ligation assay, at a stage preceding the initiation of the metastatic cascade, is coherent with such an oncogenic function. TWIST1-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 with regard to senescence inhibition over the time course of breast tumorigenesis.
Synthesis of chiral dopants based on carbohydrates.
Tsuruta, Toru; Koyama, Tetsuo; Yasutake, Mikio; Hatano, Ken; Matsuoka, Koji
2014-07-01
Chiral dopants based on carbohydrates for nematic liquid crystals were synthesized from D-glucose, and their helical twisting power (HTP) values were evaluated. The chiral dopants induced helices in the host nematic liquid crystals. An acetyl derivative having an ether-type glycosidic linkage between carbohydrate and a mesogenic moiety showed the highest HTP value of 10.4 μm(-1), while an acetyl derivative having an anomeric ester-type linkage did not show any HTP. It was surprising that this molecule had no HTP despite the presence of chirality in the molecule. A relationship between HTP and specific rotation was not observed in this study. Copyright © 2014 Elsevier Ltd. All rights reserved.
Suppression of rpoH (htpR) mutations of Escherichia coli: heat shock response in suhA revertants.
Tobe, T; Kusukawa, N; Yura, T
1987-09-01
Temperature-resistant pseudorevertants were isolated from rpoH (htpR) mutants of Escherichia coli K-12 that cannot grow at a high temperature owing to a deficiency in sigma 32 required for the induction of heat shock proteins. Among them was a class of revertants carrying a suppressor mutation, designated suhA, that suppressed all the nonsense and missense rpoH mutations tested. suhA is located at 77 min, about 1 min away from rpoH, on the genetic map. In contrast to the rpoH mutants, the suhA revertants that contained both rpoH (nonsense) and suhA mutations were fully or partially proficient in the induction of heat shock proteins upon exposure to a high temperature. Under these conditions, transcription from two heat shock promoters as determined by operon fusion was transiently activated. In one of the rpoH(Am) suhA revertants studied in detail, an increase in temperature caused the synthesis of significant amounts of sigma 32, accompanied by increased stability and accumulation of rpoH mRNAs. On the other hand, the same mutation (suhA6) only weakly suppressed the rpoH deletion mutant; however, two of the major heat shock genes, dnaK and groE, were apparently induced in the absence of sigma 32. Thus, suhA6 seems to bring about the induction of heat shock genes by at least two mechanisms, one increasing the level of sigma 32 synthesis, and the other activating some transcription factor other than sigma 32.
Shadow casted by a twisted and rotating black hole
Chen, Songbai
2016-01-01
Zhang have obtained recently a twisted rotating black hole metric, which is a vacuum solution in four-dimensional Einstein gravity. This black hole solution has a rotation parameter, but without the total angular moment. Here, we have investigated the shadow casted by a twisted rotating black hole. Our results show that the shape of the shadow of the twisted rotating black hole is a standard round disk and does not depend on the inclination angle of the observer. It means that although the twisted rotating black hole has a rotation parameter, its shadow possesses the same behaviors as the common static black hole rather than the usual Kerr-like black holes. Moreover, we find that the marginally circular orbit radius of photon is independent of the direction of photon around the black hole. The value of the marginally circular orbit radius of photon and the size of shadow increase monotonously with the rotation parameter.
Cayley-Dickson and Clifford Algebras as Twisted Group Algebras
Bales, John W
2011-01-01
The effect of some properties of twisted groups on the associated algebras, particularly Cayley-Dickson and Clifford algebras. It is conjectured that the Hilbert space of square-summable sequences is a Cayley-Dickson algebra.
Determination of Elastic Twist in Horizontal Axis Wind Turbines (HAWTs)
Energy Technology Data Exchange (ETDEWEB)
Stoddard, F.; Nelson, V.; Starcher, K.; Andrews, B.
2006-06-01
This report presents the results of a project at the Alternative Energy Institute (AEI) which measured and calculated the elastic twist of three representative composite horizontal-axis blades: Carter 300, Gougeon ESI 54, and UTRC 8 kW.
Quarks with Twisted Boundary Conditions in the Epsilon Regime
Energy Technology Data Exchange (ETDEWEB)
Thomas Mehen; Brian C. Tiburzi
2005-05-01
We study the effects of twisted boundary conditions on the quark fields in the epsilon regime of chiral perturbation theory. We consider the SU(2){sub L} x SU(2){sub R} chiral theory with non-degenerate quarks and the SU(3){sub L} x SU(3){sub R} chiral theory with massless up and down quarks and massive strange quarks. The partition function and condensate are derived for each theory. Because flavor-neutral Goldstone bosons are unaffected by twisted boundary conditions chiral symmetry is still restored in finite volumes. The dependence of the condensate on the twisting parameters can be used to extract the pion decay constant from simulations in the epsilon regime. The relative contribution to the partition function from sectors of different topological charge is numerically insensitive to twisted boundary conditions.
Spectrum of a duality-twisted Ising quantum chain
Grimm, U
2002-01-01
The Ising quantum chain with a peculiar twisted boundary condition is considered. This boundary condition, first introduced in the framework of the spin-1/2 XXZ Heisenberg quantum chain, is related to the duality transformation, which becomes a symmetry of the model at the critical point. Thus, at the critical point, the Ising quantum chain with the duality-twisted boundary is translationally invariant, similar as in the case of the usual periodic or antiperiodic boundary conditions. The complete energy spectrum of the Ising quantum chain is calculated analytically for finite systems, and the conformal properties of the scaling limit are investigated. This provides an explicit example of a conformal twisted boundary condition and a corresponding generalised twisted partition function.
The Kostant partition functions for twisted Kac-Moody algebras
Directory of Open Access Journals (Sweden)
Ranabir Chakrabarti
2000-01-01
Full Text Available Employing the method of generating functions and making use of some infinite product identities like Euler, Jacobi's triple product and pentagon identities we derive recursion relations for Kostant's partition functions for the twisted Kac-Moody algebras.
Polanski lavastas filmi "Oliver Twist" oma lastele / Andres Laasik
Laasik, Andres, 1960-2016
2005-01-01
Mängufilm "Oliver Twist" Charles Dickensi romaani ainetel esilinastus Prahas, kus toimusid ka filmivõtted. Tšehhi, Suurbritannia, Prantsusmaa ja Itaalia koostöös valminud filmi lavastas Roman Polanski
Õnnetu saatusega Oliver Twist Polanski meelevallas / Andres Laasik
Laasik, Andres, 1960-2016
2005-01-01
Mängufilm Charles Dickensi romaani järgi "Oliver Twist" : stsenarist Ronald Harwood : režissöör Roman Polanski : nimiosas Barney Clark, Fagin - Ben Kingsley : Suurbritannia - Tšehhi - Prantsusmaa - Itaalia 2005
Polarisation of microwave emission from reconnecting twisted coronal loops
Gordovskyy, Mykola; Kontar, Eduard
2016-01-01
Magnetic reconnection and particle acceleration due to the kink instability in twisted coronal loops can be a viable scenario for confined solar flares. Detailed investigation of this phenomenon requires reliable methods for observational detection of magnetic twist in solar flares, which may not be possible solely through extreme UV and soft X-ray thermal emission. The gradient of microwave polarisation across flaring loops can serve as one of the detection criteria. The aim of this study is to investigate the effect of magnetic twist in flaring coronal loops on the polarisation of gyro-synchrotron microwave emission, and determine whether microwave emission polarisation could provide a means for observational detection. We use time-dependent magnetohydrodynamic and test-particle models, developed using LARE3D and GCA codes to investigate twisted coronal loops relaxing following the kink-instability, and calculate synthetic microwave emission maps (I and V Stokes components) using GX simulator. It is found t...
Twistted ξ-(α,β expansive mappings in metric spaces
Directory of Open Access Journals (Sweden)
Poonam Nagpal
2016-04-01
Full Text Available In this paper, we introduce a pair of twisted ζ-(α,β expansive mappings in metric spaces and prove fixed point theorems for these mappings. Some examples are also provided to support our main results.
Polanski lavastas filmi "Oliver Twist" oma lastele / Andres Laasik
Laasik, Andres, 1960-2016
2005-01-01
Mängufilm "Oliver Twist" Charles Dickensi romaani ainetel esilinastus Prahas, kus toimusid ka filmivõtted. Tšehhi, Suurbritannia, Prantsusmaa ja Itaalia koostöös valminud filmi lavastas Roman Polanski
Õnnetu saatusega Oliver Twist Polanski meelevallas / Andres Laasik
Laasik, Andres, 1960-2016
2005-01-01
Mängufilm Charles Dickensi romaani järgi "Oliver Twist" : stsenarist Ronald Harwood : režissöör Roman Polanski : nimiosas Barney Clark, Fagin - Ben Kingsley : Suurbritannia - Tšehhi - Prantsusmaa - Itaalia 2005
Radiative Capture of Twisted Electrons by Bare Ions
Matula, Oliver; Serbo, Valeriy G; Surzhykov, Andrey; Fritzsche, Stephan
2014-01-01
Recent advances in the production of twisted electron beams with a subnanometer spot size offer unique opportunities to explore the role of orbital angular momentum (OAM) in basic atomic processes. In the present work, we address one of these processes: radiative recombination of twisted electrons with bare ions. Based on the density matrix formalism and the non-relativistic Schr\\"odinger theory, analytical expressions are derived for the angular distribution and the linear polarization of photons emitted due to the capture of twisted electrons into the ground state of (hydrogen-like) ions. We show that these angular and polarization distributions are sensitive to both, the transverse momentum and the topological charge of the electron beam. To observe in particular the value of this charge, we propose an experiment that makes use of the coherent superposition of two twisted beams.
A Stylistic Analysis of Register Theory in Oliver Twist
Institute of Scientific and Technical Information of China (English)
刘鑫
2015-01-01
Stylistic analysis refers to the linguistic approach to literature.Stylistics will mainly focus on the register theory,taking Charles Dickens' masterpiece Oliver Twist as a good example to demonstrate how the register theory is embodied in the work.
The Kostant partition functions for twisted Kac-Moody algebras
Ranabir Chakrabarti; Santhanam, Thalanayar S.
2000-01-01
Employing the method of generating functions and making use of some infinite product identities like Euler, Jacobi's triple product and pentagon identities we derive recursion relations for Kostant's partition functions for the twisted Kac-Moody algebras.
Applying Twisted Boundary Conditions for Few-body Nuclear Systems
Körber, Christopher
2015-01-01
We describe and implement twisted boundary conditions for the deuteron and triton systems within finite-volumes using the nuclear lattice EFT formalism. We investigate the finite-volume dependence of these systems with different twists angles. We demonstrate how various finite-volume information can be used to improve calculations of binding energies in such a framework. Our results suggests that with appropriate twisting of boundaries, infinite-volume binding energies can be reliably extracted from calculations using modest volume sizes with cubic length $L\\approx8-14$ fm. Of particular importance is our derivation and numerical verification of three-body analogue of `i-periodic' twist angles that eliminate the leading order finite-volume effects to the three-body binding energy.
Double twist helical nanofilaments in bent-core liquid crystals
Zhang, Cuiyu; Diorio, Nicholas; Lavrentovich, Oleg D.; Jakli, Antal
2014-03-01
Cryo-TEM observations on 40-150 nm films of four bent-core liquid crystal materials in their helical nanofilament (HNF) phase show that the filaments get deformed near the substrate, and the subsequent arrays of nanofilaments are not parallel, but twisted with respect to each other. The effect can explain the mysterious properties of the HNF materials, such as structural color and ambidextrous optical activity. The observed double twist structure was not expected in the previous models of this phase. Being principally different from the packing of molecules in the twist grain boundary (TGB) and blue (BP) phases, the double-twist structure of HNF expands the rich word of nanostructured organic materials. This work was financially supported by NSF DMR-0964765 and DMR 1104850. The cryo-TEM facility was supported by the Ohio Research Scholars Program. We are grateful for Prof. G. Heppke and Dr. D. Lotsch for providing the PnOPIMB materials for us.
A Stylistic Analysis of Register Theory in Oliver Twist
Institute of Scientific and Technical Information of China (English)
刘鑫
2015-01-01
Stylistic analysis refers to the linguistic approach to literature.Stylistics will mainly focus on the register theory,taking Charles Dickens’ masterpiece Oliver Twist as a good example to demonstrate how the register theory is embodied in the work.
Representations of Knot Groups and Twisted Alexander Polynomials
Institute of Scientific and Technical Information of China (English)
Xiao Song LIN
2001-01-01
We present a twisted version of the Alexander polynomial associated with a matrix representation of the knot group. Examples of two knots with the same Alexander module but differenttwisted Alexander polynomials are given.
The Algebra of Formal Twisted Pseudodifferential Symbols and a Noncommutative Residue
Zadeh, Farzad Fathi; Khalkhali, Masoud
2010-10-01
Motivated by Connes-Moscovici’s notion of a twisted spectral triple, we define an algebra of formal twisted pseudodifferential symbols with respect to a twisting of the base algebra. We extend the Adler-Manin trace and the logarithmic cocycle on the algebra of pseudodifferential symbols to our twisted setting. We also give a general method to construct twisted pseudodifferential symbols on crossed product algebras.
A super-twisted Dirac operator and Novikov inequalities
Institute of Scientific and Technical Information of China (English)
无
2000-01-01
A super-twisted Dirac operator is constructed and deformed suitably.Following Shubin's approach to Novikov inequalities associated to the deformed de Rham-Hodge operator,we give a formula for the index of the super-twisted Dirac operator,and Novikov type inequalities for the deformed operator.In particular,we obtain a purely analytic proof of the Hopf index theorem for general vector bundles.
A super-twisted Dirac operator and Novikov inequalities
Institute of Scientific and Technical Information of China (English)
冯惠涛; 郭恩力
2000-01-01
A s黳er-twisted Dirac operator is constructed and deformed suitably. Following Shubin’s approach to Novikov inequalities associated to the deformed de Rham-Hodge operator, we give a for-mula for the index of the super-twisted Dirac operator, and Novikov type inequalities for the deformed operator, In particular, we obtain a purely analytic proof of the Hopf index theorem for general vector bundles.
Geometry of Quantum Group Twists, Multidimensional Jackson Calculus and Regularization
Demichev, A. P.
1995-01-01
We show that R-matricies of all simple quantum groups have the properties which permit to present quantum group twists as transitions to other coordinate frames on quantum spaces. This implies physical equivalence of field theories invariant with respect to q-groups (considered as q-deformed space-time groups of transformations) connected with each other by the twists. Taking into account this freedom we study quantum spaces of the special type: with commuting coordinates but with q-deformed ...
Topological Twisted Sigma Model with H-flux Revisited
Energy Technology Data Exchange (ETDEWEB)
Chuang, Wu-yen
2006-08-18
In this paper we revisit the topological twisted sigma model with H-flux. We explicitly expand and then twist the worldsheet Lagrangian for bi-Hermitian geometry. we show that the resulting action consists of a BRST exact term and pullback terms, which only depend on one of the two generalized complex structures and the B-field. We then discuss the topological feature of the model.
Blade tip vortex measurements on actively twisted rotor blades
Bauknecht, André; Ewers, Benjamin; Schneider, Oliver; Raffel, Markus
2017-05-01
Active rotor control concepts, such as active twist actuation, have the potential to effectively reduce the noise and vibrations of helicopter rotors. The present study focuses on the experimental investigation of active twist for the reduction of blade-vortex interaction (BVI) effects on a model rotor. Results of a large-scale smart-twisting active rotor test under hover conditions are described. This test investigated the effects of individual blade twist control on the blade tip vortices. The rotor blades were actuated with peak torsion amplitudes of up to 2° and harmonic frequencies of 1-5/rev with different phase angles. Time-resolved stereoscopic particle image velocimetry was carried out to study the effects of active twist on the strength and trajectories of the tip vortices between ψ _ {v}= 3.6° and 45.7° of vortex age. The analysis of the vortex trajectories revealed that the 1/rev active twist actuation mainly caused a vertical deflection of the blade tip and the corresponding vortex trajectories of up to 1.3% of the rotor radius R above and -1%R below the unactuated condition. An actuation with frequencies of 2 and 3/rev significantly affected the shapes of the vortex trajectories and caused negative vertical displacements of the vortices relative to the unactuated case of up to 2%R within the first 35° of wake age. The 2 and 3/rev actuation also had the most significant effects on the vortex strength and altered the initial peak swirl velocity by up to -34 and +31% relative to the unactuated value. The present aerodynamic investigation reveals a high control authority of the active twist actuation on the strength and trajectories of the trailing blade tip vortices. The magnitude of the evoked changes indicates that the active twist actuation constitutes an effective measure for the mitigation of BVI-induced noise on helicopters.
Twisted Bundle on Noncommutative Space and U(1) Instanton
Ho, P M
2000-01-01
We study the notion of twisted bundles on noncommutative space. Due to theexistence of projective operators in the algebra of functions on thenoncommutative space, there are twisted bundles with non-constant dimension.The U(1) instanton solution of Nekrasov and Schwarz is such an example. As amathematical motivation for not excluding such bundles, we find gaugetransformations by which a bundle with constant dimension can be equivalent toa bundle with non-constant dimension.
Ambrosini, V; Morigi, J J; Nanni, C; Castellucci, P; Fanti, S
2015-03-01
Neuroendocrine neoplasms (NEN) functional imaging is an evolving field that witnessed major advances in the past two decades. The routine use of PET/CT with an array of new radiotracers to specifically study NEN resulted in an increase in lesions detection. Currently, PET radiopharmaceuticals for NEN imaging include both metabolic ([18F]DOPA, [18F]FDG, [11C]/[18F]-HTP) and receptor-mediated compounds ([68Ga]DOTA-peptides). Discussion is still on-going regarding the clinical setting that may benefit the most from the use of one tracer over the other. [68Ga]DOTA-peptides are accurate for the detection of well differentiated NEN and are increasingly employed. Moreover, providing data on somatostatin receptors expression on NEN cells, they represent a fundamental procedure to be performed before starting therapy, as well as to guide treatment, with either hot or cold somatostatin analogues. The easy and economic synthesis process also favours their clinical employment even in centres without an on-site cyclotron. [18F]DOPA is accurate for studying well differentiated tumours however the difficult and expensive synthesis have limited its clinical employment. It currently can be successfully used for imaging tumours with variable to low expression of SSR (medullary thyroid carcinoma, neuroblastoma, pheocromocytoma), that cannot be accurately studied with [68Ga]DOTA-peptides. [11C]/[18F]-HTP has also been proposed to image well differentiated NEN, on the basis of serotonin pathway activity, for which [11C]/[18F]-HTP can be used as precursor. However, although preliminary data are encouraging, the feasibility of its widespread clinical use is still under discussion, mainly limited by a complex synthesis process and more proven advantages over other currently employed compounds. This review aims to provide an overview of the current status and clinical application of PET tracers to image well differentiated NEN and to focus on the still open-issues of debate.
Twist decomposition of Drell-Yan structure functions: phenomenological implications
Brzemiński, Dawid; Motyka, Leszek; Sadzikowski, Mariusz; Stebel, Tomasz
2017-01-01
The forward Drell-Yan process in pp scattering at the LHC at √{S} = 14 TeV is considered. We analyze the Drell-Yan structure functions assuming the dominance of a Compton-like emission of a virtual photon from a fast quark scattering off the small x gluons. The color dipole framework is applied to perform quantitatively the twist decomposition of all the Drell-Yan structure functions. Two models of the color dipole scattering are applied: the Golec-Biernat-Wüsthoff model and the dipole cross section obtained from the Balitsky-Fadin-Kuraev-Lipatov evolution equation. The two models have essentially different higher twist content and the gluon transverse momentum distribution and lead to different significant effects beyond the collinear leading twist description. It is found that the gluon transverse momentum effects are significant in the Drell-Yan structure functions for all Drell-Yan pair masses M, and the higher twist effects become important for M ≲ 10GeV. It is found that the structure function W TT related to the A 2 angular coefficient and the Lam-Tung observable A 0 - A 2 are particularly sensitive to the gluon k T effects and to the higher twist effects. A procedure is suggested how to disentangle the higher twist effects from the gluon transverse momentum effects.
Twist-induced Magnetosphere Reconfiguration for Intermittent Pulsars
Huang, Lei; Tong, Hao
2016-01-01
We propose that the magnetosphere reconfiguration induced by magnetic twists in the closed field line region can account for the mode-switching of intermittent pulsars. We carefully investigate the properties of axisymmetric force-free pulsar magnetospheres with magnetic twists in closed field line region around the polar caps. The magnetosphere with twisted closed lines leads to enhanced spin-down rates. The enhancement in spin-down rate depends on the size of region with twisted closed lines. Typically, it is increased by a factor of $\\sim2$, which is consistent with the intermittent pulsars' spin down behavior during the `off' and `on' states. We find there is a threshold of maximal twist angle $\\Delta\\phi_{\\rm thres}\\sim1$. The magnetosphere is stable only if the closed line twist angle is less than $\\Delta\\phi_{\\rm thres}$. Beyond this value, the magnetosphere becomes unstable and gets untwisted. The spin-down rate would reduce to its off-state value. The quasi-periodicity in spin-down rate change can be...
Universal corner entanglement from twist operators
Bueno, Pablo; Witczak-Krempa, William
2015-01-01
The entanglement entropy in three-dimensional conformal field theories (CFTs) receives a logarithmic contribution characterized by a regulator-independent function $a(\\theta)$ when the entangling surface contains a sharp corner with opening angle $\\theta$. In the limit of a smooth surface ($\\theta\\rightarrow\\pi$), this corner contribution vanishes as $a(\\theta)=\\sigma\\,(\\theta-\\pi)^2$. In arXiv:1505.04804, we provided evidence for the conjecture that for any $d=3$ CFT, this corner coefficient $\\sigma$ is determined by $C_T$, the coefficient appearing in the two-point function of the stress tensor. Here, we argue that this is a particular instance of a much more general relation connecting the analogous corner coefficient $\\sigma_n$ appearing in the $n$th R\\'enyi entropy and the scaling dimension $h_n$ of the corresponding twist operator. In particular, we find the simple relation $h_n/\\sigma_n=(n-1)\\pi$. We show how it reduces to our previous result as $n\\rightarrow 1$, and explicitly check its validity for f...
DNA packaging in bacteriophage: is twist important?
Spakowitz, Andrew James; Wang, Zhen-Gang
2005-06-01
We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with rotation exhibits a spool-like character that is consistent with experimental and previous theoretical work, whereas feeding without rotation results in a folded conformation inconsistent with a spool conformation. The chain segment density shows a layered structure, which is more pronounced for packaging with rotation. However, in both cases, the conformation is marked by frequent jumps of the polymer chain from layer to layer, potentially influencing the ability to disentangle during subsequent ejection. Ejection simulations with and without Brownian forces show that Brownian forces are necessary to achieve complete ejection of the polymer chain in the absence of external forces.
Twisted light transmission over 143 km
Krenn, Mario; Handsteiner, Johannes; Fink, Matthias; Fickler, Robert; Ursin, Rupert; Malik, Mehul; Zeilinger, Anton
2016-11-01
Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.
Roots of Dehn twists about separating curves
Rajeevsarathy, Kashyap
2011-01-01
Let $C$ be a curve in a closed orientable surface $F$ of genus $g \\geq 2$ that separates $F$ into subsurfaces $\\widetilde {F_i}$ of genera $g_i$, for $i = 1,2$. We study the set of roots in $\\Mod(F)$ of the Dehn twist $t_C$ about $C$. All roots arise from pairs of $C_{n_i}$-actions on the $\\widetilde{F_i}$, where $n=\\lcm(n_1,n_2)$ is the degree of the root, that satisfy a certain compatibility condition. The $C_{n_i}$ actions are of a kind that we call nestled actions, and we classify them using tuples that we call data sets. The compatibility condition can be expressed by a simple formula, allowing a classification of all roots of $t_C$ by compatible pairs of data sets. We use these data set pairs to classify all roots for $g = 2$ and $g = 3$. We show that there is always a root of degree at least $2g^2+2g$, while $n \\leq 4g^2+2g$. We also give some additional applications.
Baryon masses with dynamical twisted mass fermions
Alexandrou, C; Koutsou, G; Baron, R; Guichon, P; Brinet, M; Carbonell, J; Drach, V; Liu, Z; Pène, O; Urbach, C
2007-01-01
We present results on the mass of the nucleon and the $\\Delta$ using two dynamical degenerate twisted mass quarks. The evaluation is performed at four quark masses corresponding to a pion mass in the range of 690-300 MeV on lattices of size 2.1 fm and 2.7 fm. We check for cutoff effects by evaluating these baryon masses on lattices of spatial size 2.1 fm with lattice spacings $a(\\beta=3.9)=0.0855(6)$ fm and $a(\\beta=4.05)=0.0666(6)$ fm, determined from the pion sector and find them to be within our statistical errors. Lattice results are extrapolated to the physical limit using continuum chiral perturbation theory. The nucleon mass at the physical point provides a determination of the lattice spacing. Using heavy baryon chiral perturbation theory at ${\\cal O}(p^3)$ we find $a(\\beta=3.9)=0.0879(12)$ fm, with a systematic error due to the chiral extrapolation estimated to be about the same as the statistical error. This value of the lattice spacing is in good agreement with the value determined from the pion se...
Dark Matter in a twisted bottle
Arbey, Alexandre; Deandrea, Aldo; Kubik, Bogna
2013-01-01
The real projective plane is a compact, non-orientable orbifold of Euler characteristic 1 without boundaries, which can be described as a twisted Klein bottle. We shortly review the motivations for choosing such a geometry among all possible two-dimensional orbifolds, while the main part of the study will be devoted to dark matter study and limits in Universal Extra Dimensional (UED) models based on this peculiar geometry. In the following we consider such a UED construction based on the direct product of the real projective plane with the standard four-dimensional Minkowski space-time and discuss its relevance as a model of a weakly interacting Dark Matter candidate. One important difference with other typical UED models is the origin of the symmetry leading to the stability of the dark matter particle. This symmetry in our case is a remnant of the six-dimensional Minkowski space-time symmetry partially broken by the compactification. Another important difference is the very small mass splitting between the ...
Dark Matter in a twisted bottle
Arbey, Alexandre; Cacciapaglia, Giacomo; Deandrea, Aldo; Kubik, Bogna
2013-01-01
The real projective plane is a compact, non-orientable orbifold of Euler characteristic 1 without boundaries, which can be described as a twisted Klein bottle. We shortly review the motivations for choosing such a geometry among all possible two-dimensional orbifolds, while the main part of the study will be devoted to dark matter study and limits in Universal Extra Dimensional (UED) models based on this peculiar geometry. In the following we consider such a UED construction based on the direct product of the real projective plane with the standard four-dimensional Minkowski space-time and discuss its relevance as a model of a weakly interacting Dark Matter candidate. One important difference with other typical UED models is the origin of the symmetry leading to the stability of the dark matter particle. This symmetry in our case is a remnant of the six-dimensional Minkowski space-time symmetry partially broken by the compactification. Another important difference is the very small mass splitting between the particles of a given Kaluza-Klein tier, which gives a very important role to co-annihilation effects. Finally the role of higher Kaluza-Klein tiers is also important and is discussed together with a detailed numerical description of the influence of the resonances.
McGinn, Christine K.; Laderman, Laura I.; Zimmermann, Natalie; Kitzerow, Heinz-S.; Collings, Peter J.
2013-12-01
Chromonic liquid crystals are formed by molecules that spontaneously assemble into anisotropic structures in water. The ordering unit is therefore a molecular assembly instead of a molecule as in thermotropic liquid crystals. Although it has been known for a long time that certain dyes, drugs, and nucleic acids form chromonic liquid crystals, only recently has enough knowledge been gained on how to control their alignment so that studies of their fundamental liquid crystal properties can be performed. In this article, a simple method for producing planar alignment of the nematic phase in chromonic liquid crystals is described, and this in turn is used to create twisted nematic structures of both achiral and chiral chromonic liquid crystals. The optics of 90-degree twist cells allows the anchoring strength to be measured in achiral systems, which for this alignment technique is quite weak, about 3×10-7 J/m2 for both disodium cromoglycate and Sunset Yellow FCF. The addition of a chiral amino acid to the system causes the chiral nematic phase to form, and similar optical measurements in 90-degree twist cells produce a measurement of the intrinsic pitch of the chiral nematic phase. From these measurements, the helical twisting power for L-alanine is found to be (1.1±0.4)×10-2 μm-1 wt%-1 for 15 wt% disodium cromoglycate.
Mujika, Jon I; Formoso, Elena; Mercero, Jose M; Lopez, Xabier
2006-08-03
We present an ab initio study of the acid hydrolysis of a highly twisted amide and a planar amide analogue. The aim of these studies is to investigate the effect that the twist of the amide bond has on the reaction barriers and mechanism of acid hydrolysis. Concerted and stepwise mechanisms were investigated using density functional theory and polarizable continuum model calculations. Remarkable differences were observed between the mechanism of twisted and planar amide, due mainly to the preference for N-protonation of the former and O-protonation of the latter. In addition, we were also able to determine that the hydrolytic mechanism of the twisted amide will be pH dependent. Thus, there is a preference for a stepwise mechanism with formation of an intermediate in the acid hydrolysis, whereas the neutral hydrolysis undergoes a concerted-type mechanism. There is a nice agreement between the characterized intermediate and available X-ray data and a good agreement with the kinetically estimated rate acceleration of hydrolysis with respect to analogous undistorted amide compounds. This work, along with previous ab initio calculations, describes a complex and rich chemistry for the hydrolysis of highly twisted amides as a function of pH. The theoretical data provided will allow for a better understanding of the available kinetic data of the rate acceleration of amides upon twisting and the relation of the observed rate acceleration with intrinsic differential reactivity upon loss of amide bond resonance.
Homozygous Nonsense Mutations in TWIST2 Cause Setleis Syndrome
Tukel, Turgut; Šošić, Dražen; Al-Gazali, Lihadh I.; Erazo, Mónica; Casasnovas, Jose; Franco, Hector L.; Richardson, James A.; Olson, Eric N.; Cadilla, Carmen L.; Desnick, Robert J.
2010-01-01
The focal facial dermal dysplasias (FFDDs) are a group of inherited developmental disorders in which the characteristic diagnostic feature is bitemporal scar-like lesions that resemble forceps marks. To date, the genetic defects underlying these ectodermal dysplasias have not been determined. To identify the gene defect causing autosomal-recessive Setleis syndrome (type III FFDD), homozygosity mapping was performed with genomic DNAs from five affected individuals and 26 members of the consanguineous Puerto Rican (PR) family originally described by Setleis and colleagues. Microsatellites D2S1397 and D2S2968 were homozygous in all affected individuals, mapping the disease locus to 2q37.3. Haplotype analyses of additional markers in the PR family and a consanguineous Arab family further limited the disease locus to ∼3 Mb between D2S2949 and D2S2253. Of the 29 candidate genes in this region, the bHLH transcription factor, TWIST2, was initially sequenced on the basis of its known involvement in murine facial development. Homozygous TWIST2 nonsense mutations, c.324C>T and c.486C>T, were identified in the affected members of the Arab and PR families, respectively. Characterization of the expressed mutant proteins, p.Q65X and p.Q119X, by electrophoretic mobility shift assays and immunoblot analyses indicated that they were truncated and unstable. Notably, Setleis syndrome patients and Twist2 knockout mice have similar facial features, indicating the gene's conserved role in mammalian development. Although human TWIST2 and TWIST1 encode highly homologous bHLH transcription factors, the finding that TWIST2 recessive mutations cause an FFDD and dominant TWIST1 mutations cause Saethre-Chotzen craniocynostosis suggests that they function independently in skin and bone development. PMID:20691403
Exact special twist method for quantum Monte Carlo simulations
Dagrada, Mario; Karakuzu, Seher; Vildosola, Verónica Laura; Casula, Michele; Sorella, Sandro
2016-12-01
We present a systematic investigation of the special twist method introduced by Rajagopal et al. [Phys. Rev. B 51, 10591 (1995), 10.1103/PhysRevB.51.10591] for reducing finite-size effects in correlated calculations of periodic extended systems with Coulomb interactions and Fermi statistics. We propose a procedure for finding special twist values which, at variance with previous applications of this method, reproduce the energy of the mean-field infinite-size limit solution within an adjustable (arbitrarily small) numerical error. This choice of the special twist is shown to be the most accurate single-twist solution for curing one-body finite-size effects in correlated calculations. For these reasons we dubbed our procedure "exact special twist" (EST). EST only needs a fully converged independent-particles or mean-field calculation within the primitive cell and a simple fit to find the special twist along a specific direction in the Brillouin zone. We first assess the performances of EST in a simple correlated model such as the three-dimensional electron gas. Afterwards, we test its efficiency within ab initio quantum Monte Carlo simulations of metallic elements of increasing complexity. We show that EST displays an overall good performance in reducing finite-size errors comparable to the widely used twist average technique but at a much lower computational cost since it involves the evaluation of just one wave function. We also demonstrate that the EST method shows similar performances in the calculation of correlation functions, such as the ionic forces for structural relaxation and the pair radial distribution function in liquid hydrogen. Our conclusions point to the usefulness of EST for correlated supercell calculations; our method will be particularly relevant when the physical problem under consideration requires large periodic cells.
Crowdsourcing: Global search and the twisted roles of consumers and producers
Bauer, Robert M.; Gegenhuber, Thomas
2015-01-01
Crowdsourcing spreads and morphs quickly, shaping areas as diverse as creating, organizing, and sharing knowledge; producing digital artifacts; providing services involving tangible assets; or monitoring and evaluating. Crowdsourcing as sourcing by means of ‘global search’ yields four types of values for sourcing actors: creative expertise, critical items, execution capacity, and bargaining power. It accesses cheap excess capacities at the work realm’s margins, channeling them toward production. Provision and utilization of excess capacities rationalize society while intimately connecting to a broader societal trend twisting consumers’ and producers’ roles: leading toward ‘working consumers’ and ‘consuming producers’ and shifting power toward the latter. Similarly, marketers using crowdsourcing’s look and feel to camouflage traditional approaches to bringing consumers under control preserve producer power. PMID:27524930
The Institute of Marine Engineers, One Day Seminar, PEBB: The Future of Power Electronics
2007-11-02
depending only HTP packages were developed[6]. A ceramic lid is on the process selected. Standard chip sizing, t’ electrode patterns and packages allow all...be tested at full power, before continuing to next characteristics possible -- within the chip or wafer stage of packaging. size selected. 0 8 For...changes only. These new Virtual Test Bed will be complete with system level controllers also allow dynamic changes in control visualizations and real
BKM Lie superalgebras from counting twisted CHL dyons
Govindarajan, Suresh
2010-01-01
Following Sen[arXiv:0911.1563], we study the counting of (`twisted') BPS states that contribute to twisted helicity trace indices in four-dimensional CHL models with N=4 supersymmetry. The generating functions of half-BPS states, twisted as well as untwisted, are given in terms of multiplicative eta products with the Mathieu group, M_{24}, playing an important role. These multiplicative eta products enable us to construct Siegel modular forms that count twisted quarter-BPS states. The square-roots of these Siegel modular forms turn out be precisely a special class of Siegel modular forms, the dd-modular forms, that have been classified by Clery and Gritsenko[arXiv:0812.3962]. We show that each one of these dd-modular forms arise as the Weyl-Kac-Borcherds denominator formula of a rank-three Borcherds-Kac-Moody Lie superalgebra. The walls of the Weyl chamber are in one-to-one correspondence with the walls of marginal stability in the corresponding CHL model for twisted dyons as well as untwisted ones. This lead...
The trouble with twisting (2,0) theory
Anderson, Louise
2013-01-01
We consider a twisted version of the abelian (2,0) theory placed upon a Lorenzian six-manifold with a product structure, $M_6=C \\times M_4 $. This is done by an investigation of the free tensor multiplet on the level of equations of motion, where the problem of its formulation in Euclidean signature is circumvented by letting the time-like direction lie in the two-manifold $C$ and performing a topological twist along $M_4$ alone. A compactification on $C$ is shown to be necessary to enable the possibility of finding a topological field theory. The hypothetical twist along a Euclidean $C$ is argued to amount to the correct choice of linear combination of the two supercharges scalar on $M_4$. It may be slightly surprising that this is not the same linear combination as in the well known Donaldson-Witten twist. A more surprising fact however, is that this twisted theory contains no $Q$-exact and covariantly conserved stress tensor unless $M_4$ has vanishing curvature. This is to our knowledge a phenomenon which ...
The trouble with twisting (2,0) theory
Energy Technology Data Exchange (ETDEWEB)
Anderson, Louise; Linander, Hampus [Department of Fundamental Physics, Chalmers University of Technology,S-412 96 Göteborg (Sweden)
2014-03-12
We consider a twisted version of the abelian (2,0) theory placed upon a Lorentzian six-manifold with a product structure, M{sub 6}=C×M{sub 4}. This is done by an investigation of the free tensor multiplet on the level of equations of motion, where the problem of its formulation in Euclidean signature is circumvented by letting the time-like direction lie in the two-manifold C and performing a topological twist along M{sub 4} alone. A compactification on C is shown to be necessary to enable the possibility of finding a topological field theory. The hypothetical twist along a Euclidean C is argued to amount to the correct choice of linear combination of the two supercharges scalar on M{sub 4}. This procedure is expected and conjectured to result in a topological field theory, but we arrive at the surprising conclusion that this twisted theory contains no Q-exact and covariantly conserved stress tensor unless M{sub 4} has vanishing curvature. This is to our knowledge a phenomenon which has not been observed before in topological field theories. In the literature, the setup of the twisting used here has been suggested as the origin of the conjectured AGT-correspondence, and our hope is that this work may somehow contribute to the understanding of it.
THE NONLINEAR EVOLUTION OF A TWIST IN A MAGNETIC SHOCKTUBE
Energy Technology Data Exchange (ETDEWEB)
Williams, Thomas; Taroyan, Youra [Department of Physics, IMPACS, Aberystwyth University, Aberystwyth (United Kingdom); Fedun, Viktor [Space Systems Laboratory, Department of Automatic Control and Systems Engineering, The University of Sheffield, Sheffield (United Kingdom)
2016-02-01
The interaction between a small twist and a horizontal chromospheric shocktube is investigated. The magnetic flux tube is modeled using 1.5-D magnetohydrodynamics. The presence of a supersonic yet sub-Alfvénic flow along the flux tube allows the Alfvénic pulse driven at the photospheric boundary to become trapped and amplified between the stationary shock front and photosphere. The amplification of the twist leads to the formation of slow and fast shocks. The pre-existing stationary shock is destabilized and pushed forward as it merges with the slow shock. The propagating fast shock extracts the kinetic energy of the flow and launches rapid twists of 10–15 km s{sup −1} upon each reflection. A cavity is formed between the slow and fast shocks where the flux tube becomes globally twisted within less than an hour. The resultant highly twisted magnetic flux tube is similar to those prone to kink instabilities, which may be responsible for solar eruptions. The generated torsional flux is calculated.
Probing Viscoelasticity of Cholesteric Liquid Crystals in a Twisting Cell
Angelo, Joseph; Moheghi, Alireza; Diorio, Nick; Jakli, Antal
2013-03-01
Viscoelastic properties of liquid crystals are typically studied either using Poiseuille flow, which can be produced by a pressure gradient in a capillary tube,[2] or Couette flow, which can be generated by a shear between concentric cylinders.[3] We use a different method in which we twist the liquid crystal sandwiched between two cylindrical glass plates, one of which can rotate about its center, the other of which is fixed. When the cell is twisted, there is a force proportional to the twist angle and the twist elastic constant, and inversely proportional to the pitch and sample thickness, normal to the substrates due to the change in pitch in the cholesteric liquid crystal (CLC). Measuring this force on various CLCs with known pitch we could obtain the twist elastic constants. In addition to the equilibrium force, we observed a transient force during the rotation, which is related to the flow of the material, thus allowing us to determine the Leslie viscosity component α1, which typically cannot be assessed by other methods. We expect this apparatus to be a useful tool to study the visco-elastic properties of liquid crystals. The authors acknowledge support from NSF grant DMR-0907055.
BKM Lie superalgebras from counting twisted CHL dyons
Govindarajan, Suresh
2011-05-01
Following Sen, we study the counting of (`twisted') BPS states that contribute to twisted helicity trace indices in four-dimensional CHL models with mathcal{N} = 4 supersymmetry. The generating functions of half-BPS states, twisted as well as untwisted, are given in terms of multiplicative eta products with the Mathieu group, M 24, playing an important role. These multiplicative eta products enable us to construct Siegel modular forms that count twisted quarter-BPS states. The square-roots of these Siegel modular forms turn out be precisely a special class of Siegel modular forms, the dd-modular forms, that have been classified by Clery and Gritsenko. We show that each one of these dd-modular forms arise as the Weyl-Kac-Borcherds denominator formula of a rank-three Borcherds-Kac-Moody Lie superalgebra. The walls of the Weyl chamber are in one-to-one correspondence with the walls of marginal stability in the corresponding CHL model for twisted dyons as well as untwisted ones. This leads to a periodic table of BKM Lie superalgebras with properties that are consistent with physical expectations.
DNA's Liaison with RNA Polymerase Physical Consequences of a Twisted Relationship
Kulic, Igor; Nelson, Phil
2006-03-01
RNA polymerase is the molecular motor that performs the fundamental process of transcription. Besides being the key- protagonist of gene regulation it is one of the most powerful nano-mechanical force generators known inside the cell. The fact that polymerase strictly tracks only one of DNA's strands together with DNA's helical geometry induces a force-to-torque transmission, with several important biological consequences like the ``twin supercoil domain'' effect and remote torsional interaction of genes. In the first part of the talk we theoretically explore the mechanisms of non-equilibrium transport of twist generated by a moving polymerase. We show that these equations are intrinsically non-linear in the crowded cellular environment and lead to peculiar effects like self-confinement of torsional strain by generation of alternative DNA structures like cruciforms. We demonstrate how the asymmetric conformational properties of DNA lead to a ``torsional diode'' effect, i.e. a rectification of polymerase-generated twist currents of different signs. In the second part we explore the possibility of exploiting the polymerase as a powerful workhorse for nanomechanical devices. We propose simple and easy to assemble arrangements of DNA templates interconnected by strand-hybridization that when transcribed by the polymerase linearly contract by tenfold. We show that the typical forces generated by such ``DNA stress fibers'' are in the piconewton range. We discuss their kinetics of contraction and relaxation and draw parallels to natural muscle fiber design.
Energy Technology Data Exchange (ETDEWEB)
Wang, L.; Tang, X. [Univ. of Central Lancashire. Engineering and Physical Sciences, Preston (United Kingdom); Liu, X. [Univ. of Cumbria. Sustainable Engineering, Workington (United Kingdom)
2012-07-01
The aerodynamic performance of a wind turbine depends very much on its blade geometric design, typically based on the blade element momentum (BEM) theory, which divides the blade into several blade elements. In current blade design practices based on Schmitz rotor design theory, the blade geometric parameters including chord and twist angle distributions are determined based on airfoil aerodynamic data at a specific Reynolds number. However, rotating wind turbine blade elements operate at different Reynolds numbers due to variable wind speed and different blade span locations. Therefore, the blade design through Schmitz rotor theory at a specific Reynolds number does not necessarily provide the best power performance under operational conditions. This paper aims to provide an optimal blade design strategy for horizontal-axis wind turbines operating at different Reynolds numbers. A fixed-pitch variable-speed (FPVS) wind turbine with S809 airfoil is chosen as a case study and a Matlab program which considers Reynolds number effects is developed to determine the optimized chord and twist angle distributions of the blade. The performance of the optimized blade is compared with that of the preliminary blade which is designed based on Schmitz rotor design theory at a specific Reynolds number. The results demonstrate that the proposed blade design optimization strategy can improve the power performance of the wind turbine. This approach can be further developed for any practice of horizontal axis wind turbine blade design. (Author)
"Something covered with an old blanket": Nancy and other dead mothers in Oliver Twist.
Tatum, Karen Elizabeth
2005-09-01
In Powers of Horror: An Essay on Abjection, Julia Kristeva outlines her theory of abjection as a simultaneous fascination and horror stemming from sensorial reminders of the subject's primal, psychological relation to the mother. In this essay, I show how these psychological perspectives can potentially result in acts of physical violence, which I call the "abject response." Applied to literature, a study of the abject response explains why sexually active female characters, such as Nancy, the prostitute, in Oliver Twist, suffer extreme acts of physical violence: not simply because they are sexual, as critics of Victorian domestic ideology most often argue, but rather because their particularly female bodies give them an agency which threatens to destroy the mastery of women on which Victorian male identity is based. Reading Oliver Twist through the lens of Kristeva reveals the ways in which Sikes, Nancy's murderer, psychically links her sexuality to the fatal potential he perceives in her body. This threatening construction of women's sexuality derives from an imbalanced focus in the male psyche on the repulsion aspect of abjection, a focus socially inscribed as a threatening power, which is used to justify violent usurpations of the feminine in masculine constructions of gender.
Iterative methods for overlap and twisted mass fermions
Energy Technology Data Exchange (ETDEWEB)
Chiarappa, T. [Univ. di Milano Bicocca (Italy); Jansen, K.; Shindler, A.; Wetzorke, I. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Nagai, K.I. [Wuppertal Univ. (Gesamthochschule) (Germany). Fachbereich Physik; Papinutto, M. [INFN Sezione di Roma Tre, Rome (Italy); Scorzato, L. [European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT), Villazzano (Italy); Urbach, C. [Liverpool Univ. (United Kingdom). Dept. of Mathematical Sciences; Wenger, U. [ETH Zuerich (Switzerland). Inst. fuer Theoretische Physik
2006-09-15
We present a comparison of a number of iterative solvers of linear systems of equations for obtaining the fermion propagator in lattice QCD. In particular, we consider chirally invariant overlap and chirally improved Wilson (maximally) twisted mass fermions. The comparison of both formulations of lattice QCD is performed at four fixed values of the pion mass between 230 MeV and 720 MeV. For overlap fermions we address adaptive precision and low mode preconditioning while for twisted mass fermions we discuss even/odd preconditioning. Taking the best available algorithms in each case we find that calculations with the overlap operator are by a factor of 30-120 more expensive than with the twisted mass operator. (orig.)
Adaptive dual-layer super-twisting control and observation
Edwards, Christopher; Shtessel, Yuri
2016-09-01
In this paper, a super-twisting-like structure with adaptive gains is proposed. The structure is parameterised by two scalar gains, both of which adapt, and by an additional time-varying term. The magnitudes of the adaptive terms are allowed to both increase and decrease as appropriate so that they are as small as possible, in the sense that they do not unnecessarily over-bound the uncertainty, and yet are large enough to sustain a sliding motion. In the paper, a new time varying gain is incorporated into the traditional super-twisting architecture. The proposed adaption law has a dual-layer structure which is formally analyzed using Lyapunov techniques. The additional term has the effect of simplifying the stability analysis whilst guaranteeing the second-order sliding mode properties of the traditional super-twisting scheme.
Template preparation of twisted nanoparticles of mesoporous silica
Institute of Scientific and Technical Information of China (English)
Kui Niu; Zhongbin Ni; Chengwu Fu; Tatsuo Kaneko; Mingqing Chen
2011-01-01
Optical isomers of N-lauroyl-L-(or-D-) alanine sodium salt {C12-L-(or-D-)AlaS} surfactants were used for the preparation of mesoporous silica nanoparticles with a twisted hexagonal rod-like morphology. Thermogravimetric analysis (TGA) was used to determine the temperature for template removal. Circular dichroism (CD) spectra of the surfactant solution with various compositions illustrated the formation and supramolecular assembly of protein-like molecular architecture leading to formation of twisted nanoparticles. Scanning electron microscopy (SEM),high-resolution transmission electron microscopy (HRTEM)and X-ray powder diffraction (XRD) patterns of these as-synthesized mesoporous silica confirmed that the twisted morphology of these nanoparticles was closely related to the supramolecular-assembled complex of amino acid surfactants.
Twisted Conjugacy Classes in Abelian Extensions of Certain Linear Groups
Mubeena, T
2011-01-01
Given an automorphism $\\phi:\\Gamma\\lr \\Gamma$, one has an action of $\\Gamma$ on itself by $\\phi$-twisted conjugacy, namely, $g.x=gx\\phi(g^{-1})$. The orbits of this action are called $\\phi$-twisted conjugacy classes. One says that $\\Gamma$ has the $R_\\infty$-property if there are infinitely many $\\phi$-twisted conjugacy classes for every automorphism $\\phi$ of $\\Gamma$. In this paper we show that $\\SL(n,\\bz)$ and its congruence subgroups have the $R_\\infty$-property. Further we show that any (countable) abelian extension of $\\Gamma$ has the $R_\\infty$-property where $\\Gamma$ is a torsion free non-elementary hyperbolic group, or $\\SL(n,\\bz), \\Sp(2n,\\bz)$ or a principal congruence subgroup of $\\SL(n,\\bz)$ or the fundamental group of a complete Riemannian manifold of constant negative curvature.
Twists of Pl\\"ucker coordinates as dimer partition functions
Scott, Jeanne
2013-01-01
The homogeneous coordinate ring of the Grassmannian Gr(k,n) has a cluster structure defined in terms of planar diagrams known as Postnikov diagrams. The cluster corresponding to such a diagram consists entirely of Pl\\"ucker coordinates. We introduce a twist map on Gr(k,n) related to the BZ-twist, and give an explicit Laurent expansion for the twist of an arbitrary Pl\\"ucker coordinate, in terms of the cluster variables associated with a fixed Postnikov diagram. The expansion arises as a (scaled) dimer partition function of a weighted version of the bipartite graph dual to the Postnikov diagram, modified by a boundary condition determined by the Pl\\"ucker coordinate.
Bend-twist coupling potential of wind turbine blades
DEFF Research Database (Denmark)
Fedorov, Vladimir; Berggreen, Christian
2014-01-01
In the present study an evaluation of the potential for bend-twist coupling effects in wind turbine blades is addressed. A method for evaluation of the coupling magnitude based on the results of finite element modeling and full-field displacement measurements obtained by experiments is developed...... and tested on small-scale coupled composite beams. In the proposed method the coupling coefficient for a generic beam is introduced based on the Euler-Bernoulli beam formulation. By applying the developed method for analysis of a commercial wind turbine blade structure it is demonstrated that a bend......-twist coupling magnitude of up to 0.2 is feasible to achieve in the baseline blade structure made of glass-fiber reinforced plastics. Further, by substituting the glass-fibers with carbon-fibers the coupling effect can be increased to 0.4. Additionally, the effect of introduction of bend-twist coupling...
On the Stern sequence and its twisted version
Allouche, Jean-Paul
2012-01-01
In a recent preprint on ArXiv, Bacher introduced a twisted version of the Stern sequence. His paper contains in particular three conjectures relating the generating series for the Stern sequence and for the twisted Stern sequence. Soon afterwards Coons published two papers in {\\it Integers}: first he proved these conjectures, second he used his result to obtain a correlation-type identity for the Stern sequence. We recall here a simple result of Reznick and we state a similar result for the twisted Stern sequence. We deduce an easy proof of Coons' identity, and a simple proof of Bacher's conjectures. Furthermore we prove identities similar to Coons' for variations on the Stern sequence that include Bacher's sequence.
Iterative methods for overlap and twisted mass fermions
Energy Technology Data Exchange (ETDEWEB)
Chiarappa, T. [Univ. di Milano Bicocca (Italy); Jansen, K.; Shindler, A.; Wetzorke, I. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC; Nagai, K.I. [Wuppertal Univ. (Gesamthochschule) (Germany). Fachbereich Physik; Papinutto, M. [INFN Sezione di Roma Tre, Rome (Italy); Scorzato, L. [European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT), Villazzano (Italy); Urbach, C. [Liverpool Univ. (United Kingdom). Dept. of Mathematical Sciences; Wenger, U. [ETH Zuerich (Switzerland). Inst. fuer Theoretische Physik
2006-09-15
We present a comparison of a number of iterative solvers of linear systems of equations for obtaining the fermion propagator in lattice QCD. In particular, we consider chirally invariant overlap and chirally improved Wilson (maximally) twisted mass fermions. The comparison of both formulations of lattice QCD is performed at four fixed values of the pion mass between 230 MeV and 720 MeV. For overlap fermions we address adaptive precision and low mode preconditioning while for twisted mass fermions we discuss even/odd preconditioning. Taking the best available algorithms in each case we find that calculations with the overlap operator are by a factor of 30-120 more expensive than with the twisted mass operator. (orig.)
A Topological Approach to Bend-Twist Maps with Applications
Directory of Open Access Journals (Sweden)
Anna Pascoletti
2011-01-01
Full Text Available In this paper we reconsider, in a purely topological framework, the concept of bend-twist map previously studied in the analytic setting by Tongren Ding in (2007. We obtain some results about the existence and multiplicity of fixed points which are related to the classical Poincaré-Birkhoff twist theorem for area-preserving maps of the annulus; however, in our approach, like in Ding (2007, we do not require measure-preserving conditions. This makes our theorems in principle applicable to nonconservative planar systems. Some of our results are also stable for small perturbations. Possible applications of the fixed point theorems for topological bend-twist maps are outlined in the last section.
Group dualities, T-dualities, and twisted K-theory
Mathai, Varghese
2016-01-01
This paper explores further the connection between Langlands duality and T-duality for compact simple Lie groups, which appeared in work of Daenzer-Van Erp and Bunke-Nikolaus. We show that Langlands duality gives rise to isomorphisms of twisted K-groups, but that these K-groups are trivial except in the simplest case of SU(2) and SO(3). Along the way we compute explicitly the map on $H^3$ induced by a covering of compact simple Lie groups, which is either 1 or 2 depending in a complicated way on the type of the groups involved. We also give a new method for computing twisted K-theory using the Segal spectral sequence, giving simpler computations of certain twisted K-theory groups of compact Lie groups relevant for D-brane charges in WZW theories and rank-level dualities. Finally we study a duality for orientifolds based on complex Lie groups with an involution.
Ham, J.-Y.; Lee, J.
2016-09-01
We calculate the Chern-Simons invariants of twist-knot orbifolds using the Schläfli formula for the generalized Chern-Simons function on the family of twist knot cone-manifold structures. Following the general instruction of Hilden, Lozano, and Montesinos-Amilibia, we here present concrete formulae and calculations. We use the Pythagorean Theorem, which was used by Ham, Mednykh and Petrov, to relate the complex length of the longitude and the complex distance between the two axes fixed by two generators. As an application, we calculate the Chern-Simons invariants of cyclic coverings of the hyperbolic twist-knot orbifolds. We also derive some interesting results. The explicit formulae of the A-polynomials of twist knots are obtained from the complex distance polynomials. Hence the edge polynomials corresponding to the edges of the Newton polygons of the A-polynomials of twist knots can be obtained. In particular, the number of boundary components of every incompressible surface corresponding to slope -4n+2 turns out to be 2. Bibliography: 39 titles.
Anomalous phase shift in a twisted quantum loop
Energy Technology Data Exchange (ETDEWEB)
Taira, Hisao [Division of Applied Physics, Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628 (Japan); Shima, Hiroyuki, E-mail: taira@eng.hokudai.ac.j [Department of Applied Mathematics 3, LaCaN, Universitat Politecnica de Catalunya (UPC), Barcelona 08034 (Spain)
2010-09-03
The coherent motion of electrons in a twisted quantum ring is considered to explore the effect of torsion inherent to the ring. Internal torsion of the ring composed of helical atomic configuration yields a non-trivial quantum phase shift in the electrons' eigenstates. This torsion-induced phase shift causes novel kinds of persistent current flow and an Aharonov-Bohm-like conductance oscillation. The two phenomena can occur even when no magnetic flux penetrates inside the twisted ring, thus being in complete contrast with the counterparts observed in untwisted rings.
Folding DNA into twisted and curved nanoscale shapes.
Dietz, Hendrik; Douglas, Shawn M; Shih, William M
2009-08-01
We demonstrate the ability to engineer complex shapes that twist and curve at the nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to their helical axes. Targeted insertions and deletions of base pairs cause the DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as 6 nanometers was achieved. We also combined multiple curved elements to build several different types of intricate nanostructures, such as a wireframe beach ball or square-toothed gears.
Noncommutative geometry, Grand Symmetry and twisted spectral triple
Devastato, Agostino
2015-01-01
In the noncommutative geometry approach to the standard model we discuss the possibility to derive the extra scalar field sv- initially suggested by particle physicist to stabilize the electroweak vacuum - from a "grand algebra" that contains the usual standard model algebra. We introduce the Connes-Moscovici twisted spectral triples for the Grand Symmetry model, to cure a technical problem, that is the appearance, together with the field sv, of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking making the computation of the Higgs mass compatible with the 126 GeV experimental value.
Exponential reduction of finite volume effects with twisted boundary conditions
Cherman, Aleksey; Wagman, Michael L; Yaffe, Laurence G
2016-01-01
Flavor-twisted boundary conditions can be used for exponential reduction of finite volume artifacts in flavor-averaged observables in lattice QCD calculations with $SU(N_f)$ light quark flavor symmetry. Finite volume artifact reduction arises from destructive interference effects in a manner closely related to the phase averaging which leads to large $N_c$ volume independence. With a particular choice of flavor-twisted boundary conditions, finite volume artifacts for flavor-singlet observables in a hypercubic spacetime volume are reduced to the size of finite volume artifacts in a spacetime volume with periodic boundary conditions that is four times larger.
Duality and conformal twisted boundaries in the Ising model
Grimm, U
2002-01-01
There has been recent interest in conformal twisted boundary conditions and their realisations in solvable lattice models. For the Ising and Potts quantum chains, these amount to boundary terms that are related to duality, which is a proper symmetry of the model at criticality. Thus, at criticality, the duality-twisted Ising model is translationally invariant, similar to the more familiar cases of periodic and antiperiodic boundary conditions. The complete finite-size spectrum of the Ising quantum chain with this peculiar boundary condition is obtained.
Moments of meson distribution functions with dynamical twisted mass fermions
Baron, R; Carbonell, J; Jansen, K; Liu, Z; Pène, O; Urbach, C
2007-01-01
We present our preliminary results on the lowest moment of quark distribution functions of the pion using two flavor dynamical simulations with Wilson twisted mass fermions at maximal twist. The calculation is done in a range of pion masses from 300 to 500 MeV. A stochastic source method is used to reduce inversions in calculating propagators. Finite volume effects at the lowest quark mass are examined by using two different lattice volumes. Our results show that we achieve statistical errors of only a few percent. We plan to compute renormalization constants non-perturbatively and extend the calculation to two more lattice spacings and to the nucleons.
Note on twisted elliptic genus of K3 surface
Energy Technology Data Exchange (ETDEWEB)
Eguchi, Tohru, E-mail: eguchi@yukawa.kyoto-u.ac.j [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan); Hikami, Kazuhiro, E-mail: KHikami@gmail.co [Department of Mathematics, Naruto University of Education, Tokushima 772-8502 (Japan)
2011-01-03
We discuss the possibility of Mathieu group M{sub 24} acting as symmetry group on the K3 elliptic genus as proposed recently by Ooguri, Tachikawa and one of the present authors. One way of testing this proposal is to derive the twisted elliptic genera for all conjugacy classes of M{sub 24} so that we can determine the unique decomposition of expansion coefficients of K3 elliptic genus into irreducible representations of M{sub 24}. In this Letter we obtain all the hitherto unknown twisted elliptic genera and find a strong evidence of Mathieu moonshine.
Brief Analysis of the Semantic Deviation in Oliver Twist
Institute of Scientific and Technical Information of China (English)
黄二靓
2016-01-01
As one of the foremost critical realist writers of the Victorian era, Charles Dickens is adept at using language to create all kinds of characters in a humorous or ironic tone. Therefore he received massive popularity for his unique style in storytelling. Oliver Twist is one of Charles Dickens's masterpieces and also the most appropriate choice for the stylistic study on Charles Dickens. This thesis endeavors to explore the aesthetic effect of semantic deviation appearing in Oliver Twist so that we can have a better comprehension about the excellent writing skill of Charles Dickens.
A universal coefficient theorem for twisted K-theory
Khorami, Mehdi
2010-01-01
In this paper, we recall the definition of twisted K-theory in various settings. We prove that for a twist $\\tau$ corresponding to a three dimensional integral cohomology class of a space X, there exist a "universal coefficient" isomorphism K_{*}^{\\tau}(X)\\cong K_{*}(P_{\\tau})\\otimes_{K_{*}(\\mathbb{C}P^{\\infty})} \\hat{K}_{*} where $P_\\tau$ is the total space of the principal $\\mathbb{C}P^{\\infty}$-bundle induced over X by $\\tau$ and $\\hat K_*$ is obtained form the action of $\\mathbb{C}P^{\\infty}$ on K-theory.
Stability Analysis of The Twisted Superconducting Semilocal Strings
Garaud, Julien
2007-01-01
We study the stability properties of the twisted vortex solutions in the semilocal Abelian Higgs model with a global $\\mathbf{SU}(2)$ invariance. This model can be viewed as the Weinberg-Salam theory in the limit where the non-Abelian gauge field decouples, or as a two component Ginzburg-Landau theory. The twisted vortices are characterized by a constant global current ${\\cal I}$, and for ${\\cal I}\\to 0$ they reduce to the semilocal strings, that is to the Abrikosov-Nielsen-Olesen vortices embedded into the semilocal model. Solutions with ${\\cal I}\
Noncommutative geometry, Grand Symmetry and twisted spectral triple
Devastato, Agostino
2015-08-01
In the noncommutative geometry approach to the standard model we discuss the possibility to derive the extra scalar field sv - initially suggested by particle physicist to stabilize the electroweak vacuum - from a “grand algebra” that contains the usual standard model algebra. We introduce the Connes-Moscovici twisted spectral triples for the Grand Symmetry model, to cure a technical problem, that is the appearance, together with the field sv, of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking making the computation of the Higgs mass compatible with the 126 GeV experimental value.
Wilson Loops and Area-Preserving Diffeomorphisms in Twisted Noncommutative Gauge Theory
Riccardi, M; Riccardi, Mauro; Szabo, Richard J.
2007-01-01
We use twist deformation techniques to analyse the behaviour under area-preserving diffeomorphisms of quantum averages of Wilson loops in Yang-Mills theory on the noncommutative plane. We find that while the classical gauge theory is manifestly twist covariant, the holonomy operators break the quantum implementation of the twisted symmetry in the usual formal definition of the twisted quantum field theory. These results are deduced by analysing general criteria which guarantee twist invariance of noncommutative quantum field theories. From this a number of general results are also obtained, such as the twisted symplectic invariance of noncommutative scalar quantum field theories with polynomial interactions and the existence of a large class of holonomy operators with both twisted gauge covariance and twisted symplectic invariance.
Directory of Open Access Journals (Sweden)
Yigeng Huangfu
2016-06-01
Full Text Available This paper aims to focus on the smooth output of DC-DC buck converters in wireless power transfer systems under input perturbations and load disturbances using the high-order sliding mode controller (HOSM and HOSM with super-twisting differentiator (HOSM + STD. The proposed control approach needs only measurement of converter output voltage. Theoretical analysis and design procedures, as well as the super-twisting differentiator of the proposed controller are presented in detail with the prescribed convergence law of high-order sliding modes. Comparisons of both simulation and experimental results among conventional proportional-integral (PI control, traditional sliding mode control (SMC, HOSM and HOSM + STD under various test conditions such as steady state, input voltage perturbations and output load disturbances, are presented and discussed. The results demonstrate and validate the effectiveness and robustness of the proposed control method.
Simulating QCD at the physical point with N{sub f}=2 Wilson twisted mass fermions at maximal twist
Energy Technology Data Exchange (ETDEWEB)
Abdel-Rehim, A. [The Cyprus Institute, Nicosia (Cyprus). CaSToRC; Alexandrou, C. [The Cyprus Institute, Nicosia (Cyprus). CaSToRC; Cyprus Univ. Nicosia (Cyprus). Dept. of Physics; Burger, F. [DESY Zeuthen (Germany). NIC; Collaboration: European Twisted Mass Collaboration; and others
2015-12-15
We present simulations of QCD using N{sub f}=2 dynamical Wilson twisted mass lattice QCD with physical value of the pion mass and at one value of the lattice spacing. Such simulations at a∼0.09 fm became possible by adding the clover term to the action. While O(a) improvement is still guaranteed by Wilson twisted mass fermions at maximal twist, the introduction of the clover term reduces O(a{sup 2}) cutoff effects related to isospin symmetry breaking. We give results for a set of phenomenologically interesting observables like pseudo-scalar masses and decay constants, quark masses and the anomalous magnetic moments of leptons. We mostly find remarkably good agreement with phenomenology, even though we cannot take the continuum and thermodynamic limits.
Simulating QCD at the Physical Point with $N_f=2$ Wilson Twisted Mass Fermions at Maximal Twist
Abdel-Rehim, A; Burger, F; Constantinou, M; Dimopoulos, P; Frezzotti, R; Hadjiyiannakou, K; Jansen, K; Kallidonis, C; Kostrzewa, B; Koutsou, G; Mangin-Brinet, M; Petschlies, M; Pientka, G; Rossi, G C; Urbach, C; Wenger, U
2015-01-01
We present simulations of QCD using Nf=2 dynamical Wilson twisted mass lattice QCD with physical value of the pion mass and at one value of the lattice spacing. Such simulations at ~0.09 fm became possible by adding the clover term to the action. While O(a) improvement is still guaranteed by Wilson twisted mass fermions at maximal twist, the introduction of the clover term reduces cutoff effects related to isospin symmetry breaking. We give results for a set of phenomenologically interesting observables like pseudo-scalar masses and decay constants, quark masses and the anomalous magnetic moments of leptons. We mostly find remarkably good agreement with phenomenology, even though we cannot take the continuum and thermodynamic limits.
Design and performance of a double-pitch wind turbine with non-twisted blades
Energy Technology Data Exchange (ETDEWEB)
Lanzafame, R.; Messina, M. [DIIM, Dipartimento di Ingegneria Industriale e Meccanica, Faculty of Engineering, University of Catania, Viale A. Doria, 6, 95125 Catania (Italy)
2009-05-15
A new design has been proposed for inexpensive wind turbine blades with high power coefficients. The new wind turbine blade has been subdivided into two, each with a different pitch angle, to optimise aerodynamic flow, absence of twist, and carries a variable chord along the blade itself. The new blade reveals some energy loss due to the tip vortices of each blade part (which can be minimised by winglets), yet proves that it is possible to create a wind turbine with high power coefficients. To design and evaluate the performance of the new wind turbine a numerical code, developed by the authors and based on blade element momentum theory, was implemented after validation by experimental measurement found in scientific literature. The code led to better choices of layout to maximise turbine performance. (author)
Mazzio, Elizabeth A; Bauer, David; Mendonca, Patricia; Taka, Equar; Soliman, Karam F A
2017-01-15
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells. Validation studies were performed showing a pro-inflammatory profile of [LPS 3 µg/ml/ IFNγ 3 ng/ml] consistent with greater release [>8.5 fold] of MCP-1, NO2-, cytokine-induced neutrophil chemo-attractants (CINC) 1, CINC 2a and CINC3. The data show no changes to the following, IL-13, TNF-a, fracktaline, leptin, LIX, GM-CSF, ICAM1, L-Selectin, activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, prolactin R, RAGE, IL-6, Thymus Chemokine-1, CNTF,IL-10 or TIMP-1. A HTP screening was conducted, where we employ an in vitro efficacy index (iEI) defined as the ratio of toxicity (LC50)/anti-inflammatory potency (IC50). The iEI was precautionary to ensure biological effects were occurring in fully viable cells (ratio > 3.8) independent of toxicity. Using NO2- as a guideline molecule, the data show that 1.77% (25 of 1410 tested) had anti-inflammatory effects with iEI ratios >3.8 and IC50s 1750.0μg/ml, and the compound with the greatest iEI was quercetin where the IC50/LC50 was 10.0/>363.6μg/ml. These substances also downregulate the production of iNOS expression and attenuate CINC-3 release. In summary, this HTP screening provides guideline information about the efficacy of natural products that could prevent inflammatory processes associated with neurodegenerative disease and aggressive glioma tumor growth. Copyright © 2016 Elsevier B.V. All rights
Moiré scaling of the sliding force in twisted bilayer graphene
Koren, E.; Duerig, U.
2016-07-01
The weak interlayer binding in two-dimensional layered materials such as graphite gives rise to distinguished low-friction properties if the atomic lattices at the interface are rotated with respect to one another. The lack of crystal symmetry leads to poorly understood correlations and cancelations of the interlayer atomic forces. Here we report on a powerful tiling method based on the moiré superstructure which allows us to study the intricate interplay of the interlayer forces in a systematic manner. Based on numerical simulation data for a circular graphene flake on an infinite graphene substrate, it is shown that the sliding force is dominated by a rim area consisting of incomplete moiré tiles. This rim force, which scales with the number of atoms in a moiré tile and as the radius to the power of 0.5, is minimal whenever the sliding structure can be approximated by a hexagon composed of an integer number Nt of moiré tiles. Intriguingly, the corresponding area force scales as Nt to the power of 0.25, i.e., it increases with size, whereas it has been often argued that interlayer forces should add up to a zero value for large twisted systems. However, at specific twist angles the moiré structure is commensurate with the graphene lattice, leading to a perfect force correlation in the moiré tiles. Correspondingly, the area force becomes dominant and scales as Nt, i.e., as the radius to the power of 2.
On the space of connections having non-trivial twisted harmonic spinors
Energy Technology Data Exchange (ETDEWEB)
Bei, Francesco, E-mail: bei@math.hu-berlin.de [Institut für Mathematik, Humboldt Universität zu Berlin, Unter den Linden 6, 10099 Berlin (Germany); Waterstraat, Nils, E-mail: n.waterstraat@kent.ac.uk [School of Mathematics, Statistics & Actuarial Science, University of Kent, Canterbury, Kent CT2 7NF (United Kingdom)
2015-09-15
We consider Dirac operators on odd-dimensional compact spin manifolds which are twisted by a product bundle. We show that the space of connections on the twisting bundle which yields an invertible operator has infinitely many connected components if the untwisted Dirac operator is invertible and the dimension of the twisting bundle is sufficiently large.
Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells
Institute of Scientific and Technical Information of China (English)
Geng-Qiu Luo; Jing-He Li; Ji-Fang Wen; Yan-Hong Zhou; Yong-Bin Hu; Jian-Hua Zhou
2008-01-01
AIM: To study the effect of the transfected Twist gene on invasion and metastasis of gastric carcinoma cells and the possible mechanisms involved.METHODS: Human gastric carcinoma MKN28 cells were stably transfected with Twist sense plasmid, and MKN45 cells were stably transfected with Twist antisense plasmid using the lipofectamine transfection technique.RT-PCR,Western blotting, ENSA, gelatin zymography assay, and in vitro invasion and migration assays were performed.Nude mice metastasis models were established by the abdominal cavity transfer method.RESULTS: Cell models (TwistS-MKN28) that steadily expressed high Twist protein were obtained.Compared with MKN28 and pcDNA3-MKN28 cells, adherence,migration and invasion ability of TwistS-MKN28 cells were clearly raised.The number of cancer nodules was increased significantly in the abdominal cavity and liver of nude mice inoculated with TwistS-MKN28 cells.Overexpression of Twist in MKN28 cells increased Tcf-4/Lef DNA binding activity, and promoted expression of Tcf-4's downstream target genes cyclin Dt and HMP-2.However, suppression of Twist (TwistAS-NKN45) inhibited MKN45 cell invasion and the expression of cyclin D1 was reduced.The activity of MMP-2 was also decreased.CONCLUSION: These results indicate that Twist promotes gastric cancer cell migration, invasion and metastasis, and Twist may play an important role in Wnt/Tcf-4 signaling.
Gauge theory on twisted kappa-Minkowski: old problems and possible solutions
Dimitrijevic, Marija; Pachol, Anna
2014-01-01
We review the application of twist deformation formalism and the construction of noncommutative gauge theory on kappa-Minkowski space-time. We compare two different types of twists: the Abelian and the Jordanian one. In each case we provide the twisted differential calculus and consider U(1) gauge theory. Different methods of obtaining a gauge invariant action and related problems are thoroughly discussed.
Gauge Theory on Twisted kappa-Minkowski: Old Problems and Possible Solutions
Dimitrijević, Marija; Jonke, Larisa; Pachoł, Anna
2014-06-01
We review the application of twist deformation formalism and the construction of noncommutative gauge theory on κ-Minkowski space-time. We compare two different types of twists: the Abelian and the Jordanian one. In each case we provide the twisted differential calculus and consider {U}(1) gauge theory. Different methods of obtaining a gauge invariant action and related problems are thoroughly discussed.
Twist decomposition of Drell-Yan structure functions: phenomenological implications
Brzeminski, Dawid; Sadzikowski, Mariusz; Stebel, Tomasz
2016-01-01
The forward Drell--Yan process in $pp$ scattering at the LHC at $\\sqrt{S}=14$ TeV is considered. We analyze the Drell--Yan structure functions assuming the dominance of a Compton-like emission of a virtual photon from a fast quark scattering off the small $x$ gluons. The color dipole framework is applied to perform quantitatively the twist decomposition of all the Drell--Yan structure functions. Two models of the color dipole scattering are applied: the Golec-Biernat--W\\"{u}sthoff model and the dipole cross section obtained from the Balitsky--Fadin--Kuraev--Lipatov evolution equation. The two models have essentially different higher twist content and the gluon transverse momentum distribution and lead to different significant effects beyond the collinear leading twist description. It is found that the gluon transverse momentum effects are significant in the Drell--Yan structure functions for all Drell--Yan pair masses $M$, and the higher twist effects become important for $M \\lesssim 10$ GeV. It is found that...
Twisting singular solutions of Betheʼs equations
Nepomechie, Rafael I.; Wang, Chunguang
2014-12-01
The Bethe equations for the periodic XXX and XXZ spin chains admit singular solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to be physical, in which case they correspond to genuine eigenvalues and eigenvectors of the Hamiltonian.
DVCS on the nucleon to the twist-3 accuracy
Kivel, N A
2001-01-01
The amplitude of the deeply virtual Compton scattering off nucleon is computed to the twist-3 accuracy in the Wandzura-Wilczek (WW) approximation. The result is presented in the form which can be easily used for analysis of DVCS observables.
Renormalization of four-fermion operators for higher twist calculations
Capitani, S; Horsley, R; Perlt, H; Rakow, P E L; Schierholz, G; Schiller, A
1999-01-01
The evaluation of the higher twist contributions to Deep Inelastic Scattering amplitudes involves a non trivial choice of operator bases for the higher orders of the OPE expansion of the two hadronic currents. In this talk we discuss the perturbative renormalization of the four-fermion operators that appear in the above bases.
Photoelectric Effect for Twist-deformed Space-time
Daszkiewicz, M.
In this article, we investigate the impact of twisted space-time on the photoelectric effect, i.e., we derive the $\\theta$-deformed threshold frequency. In such a way we indicate that the space-time noncommutativity strongly enhances the photoelectric process.
Exploring the epsilon regime with twisted mass fermions
Jansen, K; Shindler, A; Urbach, C; Wenger, U
2007-01-01
In this proceeding contribution we report on a first study in order to explore the so called epsilon regime with Wilson twisted mass (Wtm) fermions. To show the potential of this approach we give a preliminary determination of the chiral condensate.
A mod 2 index theorem for the twisted Signature operator
Institute of Scientific and Technical Information of China (English)
张伟平
1999-01-01
A mod 2 index theorem for the twisted Signature operator on 4q+1 dimensional manifolds is established. This result generalizes a result of Farber and Turaev, which was proved for the case of orthogonal flat bundles, to arbitrary real vector bundles. It also provides an analytic interpretation of the sign of the Poincar(?)-Reidemeister scalar product defined by Farber and Turaev.
Action of the cork twist on Floer homology
Akbulut, Selman
2011-01-01
We utilize the Ozsvath-Szabo contact invariant to detect the action of involutions on certain homology spheres that are surgeries on symmetric links, generalizing a previous result of Akbulut and Durusoy. Potentially this may be useful to detect different smooth structures on 4-manifolds by cork twisting operation.
Twist-related locomotion of a snake-like robot
Institute of Scientific and Technical Information of China (English)
Ye Changlong; Ma Shugen; Li Bin; Wang Yuechao; Jing Tao
2006-01-01
As a hyper-redundant robot, a 3D snake-like robot can perform many other configurations and types of locomotion adapted to environment except for mimicking the natural snake locomotion. The natural snake locomotion usually limits locomotion capability of the robot because of inadequacy in the mechanism and actuation to imitate characters of natural snake such as the too many DOFs and the characteristics of the muscle. In order to apply snake-like robots to the unstructured environment, the researchers have designed many gaits for increasing the adaptability to a variety of surroundings. The twist-related locomotion is an effective gait achieved by jointly driving the pitching-DOF and yawing-DOF, with which the snakelike robot can move on rough ground and even climb up some obstacles. In this paper, the twist-related locomotion function is firstly solved, and simplified to be expressible by sine or cosine function. The 2D locomotion such as V-shape and U-shape is achieved. Also by applying it to the serpentine locomotion or other types of locomotion, the snake-like robot can complete composite locomotion that combines the serpentine locomotion or others with twist-related locomotion. Then we extend the twist-related locomotion to 3D space. Finally, the experimental results are presented to validate all above analyses.
Twist and its effect on ACL graft forces.
Arnold, M.P.; Blankevoort, L.; Ham, A. ten; Verdonschot, N.J.J.; Kampen, A. van
2004-01-01
Graft tension is a controversial topic in anterior cruciate ligament (ACL) surgery. Evidence suggests a narrow range of graft tensions, which allow the graft to remodel to a stable and mature neoligament. In previous cadaver experiments, we showed that twisting the graft could modulate the graft for
Higher-Twist Dynamics in Large Transverse Momentum Hadron Production
Energy Technology Data Exchange (ETDEWEB)
Arleo, Francois; /Annecy, LAPTH; Brodsky, Stanley J.; /SLAC; Hwang, Dae Sung; /Sejong U.; Sickles, Anne M.; /Brookhaven
2009-12-17
A scaling law analysis of the world data on inclusive large-p{sub {perpendicular}} hadron production in hadronic collisions is carried out. A significant deviation from leading-twist perturbative QCD predictions at next-to-leading order is reported. The observed discrepancy is largest at high values of x{sub {perpendicular}} = 2p{sub {perpendicular}}/{radical}s. In contrast, the production of prompt photons and jets exhibits the scaling behavior which is close to the conformal limit, in agreement with the leading-twist expectation. These results bring evidence for a non-negligible contribution of higher-twist processes in large-p{sub {perpendicular}} hadron production in hadronic collisions, where the hadron is produced directly in the hard subprocess rather than by gluon or quark jet fragmentation. Predictions for scaling exponents at RHIC and LHC are given, and it is suggested to trigger the isolated large-p{sub {perpendicular}} hadron production to enhance higher-twist processes.
Twisted Conformal Algebra and Quantum Statistics of Harmonic Oscillators
Directory of Open Access Journals (Sweden)
J. Naji
2014-01-01
Full Text Available We consider noncommutative two-dimensional quantum harmonic oscillators and extend them to the case of twisted algebra. We obtained modified raising and lowering operators. Also we study statistical mechanics and thermodynamics and calculated partition function which yields the free energy of the system.
Determinant of twisted chiral Dirac Operator on the Lattice
Fosco, C. D.; Randjbar-Daemi, S.
1995-01-01
Using the overlap formulation, we calculate the fermionic determinant on the lattice for chiral fermions with twisted boundary conditions in two dimensions. When the lattice spacing tends to zero we recover the results of the usual string-theory continuum calculations.
Twisted accretion discs. Pt. 3. Application to Epsilon Aurigae
Energy Technology Data Exchange (ETDEWEB)
Kumar, S.
1987-04-15
Twisting and alignment in a steady-state circumbinary accretion disc is studied. It is then used to account for observed features in the scenario of Epsilon Aurigae as a triple. The alignment depends on viscosity in the disc, but it is always substantial and leads to a tilted slab-like profile when viewed edge-on.
Real bundle gerbes, orientifolds and twisted KR-homology
Hekmati, Pedram; Szabo, Richard J; Vozzo, Raymond F
2016-01-01
We introduce a notion of Real bundle gerbes on manifolds equipped with an involution. We elucidate their relation to Jandl gerbes and prove that they are classified by their Real Dixmier-Douady class in Grothendieck's equivariant sheaf cohomology. We show that the Grothendieck group of Real bundle gerbe modules is isomorphic to twisted KR-theory for a torsion Real Dixmier-Douady class. Building on the Baum-Douglas model for K-homology and the orientifold construction in string theory, we introduce geometric cycles for twisted KR-homology groups using Real bundle gerbe modules. We prove that this defines a real-oriented generalised homology theory dual to twisted KR-theory for Real closed manifolds, and more generally for Real finite CW-complexes, for any Real Dixmier-Douady class. This is achieved by defining an explicit natural transformation to analytic twisted KR-homology and proving that it is an isomorphism. Our constructions give a new framework for the classification of orientifolds in string theory, p...
Twist and its effect on ACL graft forces
Arnold, MP; Blankevoort, L; ten Ham, A; Verdonschot, N; van Kampen, A
2004-01-01
Graft tension is a controversial topic in anterior cruciate ligament (ACL) surgery. Evidence suggests a narrow range of graft tensions, which allow the graft to remodel to a stable and mature neoligament. In previous cadaver experiments, we showed that twisting the graft could modulate the graft for
Nucleon Structure in Lattice QCD using twisted mass fermions
Alexandrou, C; Korzec, T; Carbonell, J; Harraud, P A; Papinutto, M; Guichon, P; Jansen, K
2010-01-01
We present results on the nucleon form factors and moments of generalized parton distributions obtained within the twisted mass formulation of lattice QCD. We include a discussion of lattice artifacts by examining results at different volumes and lattice spacings. We compare our results with those obtained using different discretization schemes and to experiment.
Nucleon form factors with dynamical twisted mass fermions
Alexandrou, C; Brinet, M; Carbonell, J; Drach, V; Harraud, P A; Korzec, T; Koutsou, G
2008-01-01
The electromagnetic and axial form factors of the nucleon are evaluated in twisted mass QCD with two degenerate flavors of light, dynamical quarks. The axial charge g_A, magnetic moment and the Dirac and Pauli radii are determined for pion masses in the range 300 MeV to 500 MeV.
Static-light meson masses from twisted mass lattice QCD
Jansen, K; Shindler, A; Wagner, M
2008-01-01
We compute the static-light meson spectrum using two-flavor Wilson twisted mass lattice QCD. We have considered five different values for the light quark mass corresponding to 300 MeV < m_PS < 600 MeV. We have extrapolated our results, to make predictions regarding the spectrum of B and B_s mesons.
Photoelectric effect for twist-deformed space-time
Daszkiewicz, Marcin
2016-01-01
In this article, we investigate the impact of twisted space-time on the photoelectric effect, i.e., we derive the $\\theta$-deformed threshold frequency. In such a way we indicate that the space-time noncommutativity strongly enhances the photoelectric process.
An HTP kinetics study of the reaction between ground-state H atoms and NH3 from 500 to 1140 K
Marshall, Paul; Fontijn, Arthur
1986-09-01
The H+NH3 reaction has been investigated using the high-temperature photochemistry (HTP) technique. H(1 2S) atoms were generated by flash photolysis of NH3 and monitored by time-resolved atomic resonance fluorescence with pulse counting. The rate coefficient for 660≤T≤1140 K is given by k(T)=(5.7±2.8)×10-10 exp[(-8650±410)K/T] cm3 molecule-1 s-1, where the uncertainties represent one standard deviation based on a propagation of error treatment including systematic errors. The Arrhenius plot reveals curvature between 500 and 660 K which follows the results of quantum mechanical tunneling calculations based on transition state theory and an Eckart potential.
Darmani, N A; Shaddy, J; Elder, E L
1997-01-01
Recent in vivo microdialysis studies have indicated that presynaptic deficits occur in brain 5-HT neurochemistry during cocaine withdrawal. The purpose of the present study was to utilize the head-twitch response (HTR) produced by 5-hydroxytryptophan (5-HTP) to investigate the dose- and time-response effects of this deficit. The HTR is considered to be a sensitive model for activation of central postsynaptic 5-HT2A receptors in rodents. Thus, different groups of mice were injected with cocaine twice daily (0, 0.1, 0.5, 2.5, 5 or 10 mg/kg, i.p.) for 7 or 13 days. During HTR testing, at 24 h following last injection, the treated mice received either 1) no cocaine; 2) their corresponding daily dose as challenge injection; or 3) a 10 mg/kg challenge dose. In a second series of experiments, extended abstinence studies were performed under the conditions of experimental protocols 1 and 2 for both 7- and 13-day cocaine (0, 0.5 and 5 mg/kg, twice daily) exposure regimens at 24, 48, 72 and 96 h following last cocaine injection. In protocol 3, the effects of a 10 mg/kg challenge dose of cocaine were studied following prolonged withdrawal from chronic cocaine exposure (0, 0.5, 5 and 10 mg/kg, twice daily for 7 and 13 days) at 24, 96 and 240 h abstinence. In experimental protocol 1 at 24 h abstinence in the 7 day exposure group, only lower doses of cocaine (0.5-2.5 mg/kg) significantly attenuated the 5-HTP-induced HTR. The deficit in 0.5 mg/kg group persisted up to 72 h abstinence. Although in the 13 day cocaine exposure groups (experimental paradigm 1) mean HTRs were generally reduced, they however failed to attain statistical significance throughout the 96 h abstinence. In protocol 2 very low challenge doses of cocaine (0.1-0.5 mg/kg) in their corresponding pretreatment groups significantly reduced the behavior at diverse abstinence intervals in both 7- and 13-day exposure regimens relative to their chronically vehicle-treated controls which had received a vehicle challenge
Rysz, Marta; Bromek, Ewa; Daniel, Władysława A
2016-01-01
Our recent studies suggest that brain serotonergic system may be involved in the neuroendocrine regulation of cytochrome P450 expression. Intracerebral injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine affected serum hormone concentration and increased the expression and activity of the hormone-dependent isoforms CYP1A1/2, CYP2C11 and CYP3A1. Therefore, the aim of the present study was to investigate the effect of stimulation of brain serotonergic system on cytochrome P450 expression in the liver. The serotonin precursor 5-hydroxytryptophan (5-HTP) was injected for 5 days to the lateral ventricles of rat brain. Afterwards, the brain concentrations of serotonin and its metabolite 5-hydroxyindoleacetic acid 5-HIAA, serum hormone levels and liver cytochrome P450 expression and activity were measured. 5-HTP potently increased the concentration of serotonin and its metabolite 5-HIAA in all the brain structures studied including the hypothalamus. The brain concentrations of noradrenaline or dopamine and its metabolites were not changed in that structure. At the same time, a significant decrease in the serum concentration of the growth hormone and an increase in that of thyroxine were observed. In the liver, the activity of CYP1A, CYP2A, CYP2B, CYP2C11 and CYP3A was diminished, which positively correlated with a decrease in the respective CYP protein levels and a reduction in the mRNA levels of CYP1A2, CYP2A2, CYP2C11, CYP3A1 and CYP3A2. The obtained results provide evidence to prove that brain serotonergic system negatively regulates liver cytochrome P450 expression via endocrine system and suggest mechanisms by which this enzyme may be regulated by drugs with a serotonergic profile such as antidepressants. Copyright © 2015 Elsevier Inc. All rights reserved.
Fogarty, David E.; Wilbur, Matthew L.; Sekula, Martin K.; Boyd, David Douglas, Jr.
2012-01-01
Numerical predictions of the acoustic characteristics of an Active Twist Rotor (ATR), using two methods to compute the rotor blade aerodynamics and elastic blade motion are compared to experimental data from a wind tunnel test in the NASA Langley Transonic Dynamics Tunnel (TDT) in 2000. The first method, a loosely coupled iterative method, utilizes the Computational Fluid Dynamics (CFD) code OVERFLOW 2 and the Computational Structural Dynamics (CSD) code CAMRAD II. The second method utilizes the CAMRAD II free-wake model only. The harmonic active-twist control to the main rotor blade system is identified with three parameters - harmonic actuation frequency, actuation amplitude, and control phase angle. The resulting aerodynamics and blade motion data from the two methods are then used in the acoustics code PSU-WOPWOP to predict acoustic pressure on a spherical array of equally spaced observers surrounding the rotor. This spherical distribution of pressure is used to compute the sound power level representing baseline and actuated conditions. Sound power levels for three categories of noise are defined as - blade-vortex interaction sound power level (BVIPWL), low frequency sound power level (LFPWL), and overall sound power level, OAPWL. Comparisons with measured data indicate the CFD/CSD analysis successfully captures the trends in sound power levels and the effects of active-twist control at advance ratios of 0.14 and 0.17. The free-wake model predictions show inconsistent sound power levels relative to the trends in the experimental and CFD data. This paper presents the first ever comparison between CFD/CSD acoustic predictions for an active-twist rotor and experimental measurements.
Quinteiro, G F; Kuhn, T
2014-01-01
Twisted light is light carrying orbital angular momentum. The profile of such a beam is a ring-like structure with a node at the beam axis, where a phase singularity exits. Due to the strong spatial inhomogeneity the mathematical description of twisted light-matter interaction is non-trivial, in particular at the phase singularity, where the commonly used dipole-moment approximation cannot be applied. In this paper we show theoretically that, if the polarization and the orbital angular momentum of the twisted light beam have the same sign, a Hamiltonian similar to the dipole-moment approximation can be derived. However, if the signs of polarization and orbital angular momentum differ, the magnetic parts of the light beam become of significant importance and an interaction Hamiltonian which only accounts for electric fields, as in the dipole moment approximation, is inappropriate. We discuss the consequences of these findings for twisted light excitation of semiconductor nanostructures, e. g. a quantum dot, pl...
Small x behavior of parton distributions. A study of higher twist effects
Illarionov, A Yu; Parente, G; Illarionov, Alexei Yu.; Kotikov, Anatoly V.; Parente, Gonzalo
2004-01-01
Higher twist corrections to the structure function F_2 at small x are studied for the case of a flat initial condition for the twist-two QCD evolution in the next-to-leading order approximation. We present an analytical parameterization of the contributions from the twist-two and higher twist operators of the Wilson operator product expansion. Higher twist terms are evaluated using two different approaches, one motivated by BFKL and the other motivated by the renormalon formalism. The results of the latter approach are in very good agreement with deep inelastic scattering data from HERA.
Automatic O(a) improvement for twisted mass QCD in the presence of spontaneous symmetry breaking
Aoki, Sinya; Bär, Oliver
2006-08-01
In this paper we present a proof for automatic O(a) improvement in twisted mass lattice QCD at maximal twist, which uses only the symmetries of the leading part in the Symanzik effective action. In the process of the proof we clarify that the twist angle is dynamically determined by vacuum expectation values in the Symanzik theory. For maximal twist according to this definition, we show that scaling violations of all quantities which have nonzero values in the continuum limit are even in a. In addition, using Wilson chiral perturbation theory, we investigate this definition for maximal twist and compare it to other definitions which were already employed in actual simulations.
Ko, Sangwon
2012-03-21
Conjugated polymers with nearly planar backbones have been the most commonly investigated materials for organic-based electronic devices. More twisted polymer backbones have been shown to achieve larger open-circuit voltages in solar cells, though with decreased short-circuit current densities. We systematically impose twists within a family of poly(hexylthiophene)s and examine their influence on the performance of polymer:fullerene bulk heterojunction (BHJ) solar cells. A simple chemical modification concerning the number and placement of alkyl side chains along the conjugated backbone is used to control the degree of backbone twisting. Density functional theory calculations were carried out on a series of oligothiophene structures to provide insights on how the sterically induced twisting influences the geometric, electronic, and optical properties. Grazing incidence X-ray scattering measurements were performed to investigate how the thin-film packing structure was affected. The open-circuit voltage and charge-transfer state energy of the polymer:fullerene BHJ solar cells increased substantially with the degree of twist induced within the conjugated backbone-due to an increase in the polymer ionization potential-while the short-circuit current decreased as a result of a larger optical gap and lower hole mobility. A controlled, moderate degree of twist along the poly(3,4-dihexyl-2,2′:5′,2′′- terthiophene) (PDHTT) conjugated backbone led to a 19% enhancement in the open-circuit voltage (0.735 V) vs poly(3-hexylthiophene)-based devices, while similar short-circuit current densities, fill factors, and hole-carrier mobilities were maintained. These factors resulted in a power conversion efficiency of 4.2% for a PDHTT:[6,6]-phenyl-C 71-butyric acid methyl ester (PC 71BM) blend solar cell without thermal annealing. This simple approach reveals a molecular design avenue to increase open-circuit voltage while retaining the short-circuit current. © 2012 American
Khan, Saba N; Chatterjee, Sudip K; Chaudhuri, Partha Roy
2016-01-01
We report here the experimental demonstration of measurement of both twist and transverse stress using polarization modulation in a single all-fiber circuit consisting of a single-mode fiber (SMF)/dual-mode fiber (DMF) in a Sagnac interferometer (SI) loop. The SMF-SI prototype setup is seen to be suitable for precise measurement of twist over a broad range of ±50° and transverse stress up to 5 N with a sensitivity as high as 2.85×10(6) pW/° and 2.08×10(7) pW/N, respectively. It is envisaged that nearly ideal operation for twist measurement can be achieved by appropriately selecting the operating domain (pretwisted Sagnac loop for practical realization of the device) and required magnitude of applied transverse stress (weight yielding maximum sensitivity). Unlike SMF-SI, a DMF assisted SI exhibits asymmetric transmittance yielding a peak shift (∼45°) in addition to falling/rising peak amplitude of effective power(∼20 μW). This key characteristic is further utilized for tunable measurement of torsion (unidirectional from -70° to 40°) while keeping the sensitivity fixed. This research problem is then analyzed on the avenue of theoretical consideration and using classical polarization optics; we have derived the Jones birefringence matrix that accurately describes the transmission behavior of the configured fiber circuit (SMF-SI and DMF-SI) for each of the three cases, namely, transverse stress, twist, and both twist and transverse stress. Series of experimental measurements for various conditions of induced birefringence (linear/circular) were performed at length, and the results were compared with those determined theoretically towards configuring a twist and stress measuring device. The study provides an understanding of the underlying physics of dual-mode interference in a Sagnac configuration experiencing linear and circular birefringence.
Nightingale, R. W.; Ma, G.; Ji, E.
2009-12-01
In our previous studies of rotating sunspots about their umbral centers over the past decade, we have been measuring the rotation at the photosphere of the cross sections of large, twisted magnetic flux tubes passing through from below. Many such rotating sunspots have been found and reported in the literature and at earlier meetings [e.g., Brown et al., Sol. Phys. 216, 79, 2003; Yan et al., ApJ 682, L65, 2008; Nightingale et al., Fall AGU Mtg. 2007]. Here we are attempting to measure the rotation of 1 million degree K EUV loops seen in TRACE 171A images emerging from what may be a large 6000 deg K magnetic flux tube (invisible at EUV), which may be the extension of the associated rotating sunspot up in the corona, for active region 9114 on August 8 - 10, 2000. These nonpotential EUV loops appear to be attached at their other end to nonrotating opposite polarity magnetic flux regions and also appear to be flipping around like a twisted jump rope that is attached to a wall at one end. In movies of these twisted coronal loop fans the rotation appears obvious, but is difficult to measure, because of the constant motion and change of intensity of the fans, which tend to obscure each other and the apparent tube center. We will show movies over the 3 days of the twisted loop fans, and details and first results of our measurements, which appear to be similar to those previously found for the associated rotating sunspot down at the photosphere. We will discuss how the twisted magnetic flux tube energizes the corona, carrying energy up from beneath the photosphere. This work was supported by NASA under the TRACE contract NAS5-38099.
Boyd, David D. Jr.
2009-01-01
Preliminary aerodynamic and performance predictions for an active twist rotor for a HART-II type of configuration are performed using a computational fluid dynamics (CFD) code, OVERFLOW2, and a computational structural dynamics (CSD) code, CAMRAD -II. These codes are loosely coupled to compute a consistent set of aerodynamics and elastic blade motions. Resultant aerodynamic and blade motion data are then used in the Ffowcs-Williams Hawkins solver, PSU-WOPWOP, to compute noise on an observer plane under the rotor. Active twist of the rotor blade is achieved in CAMRAD-II by application of a periodic torsional moment couple (of equal and opposite sign) at the blade root and tip at a specified frequency and amplitude. To provide confidence in these particular active twist predictions for which no measured data is available, the rotor system geometry and computational set up examined here are identical to that used in a previous successful Higher Harmonic Control (HHC) computational study. For a single frequency equal to three times the blade passage frequency (3P), active twist is applied across a range of control phase angles at two different amplitudes. Predicted results indicate that there are control phase angles where the maximum mid-frequency noise level and the 4P non -rotating hub vibrations can be reduced, potentially, both at the same time. However, these calculated reductions are predicted to come with a performance penalty in the form of a reduction in rotor lift-to-drag ratio due to an increase in rotor profile power.
Energy consumption of Twisted File instrument used with rotary or reciprocating adaptive motion
Directory of Open Access Journals (Sweden)
Taha Ozyurek
2016-01-01
Full Text Available Objective: The aim of this study was to compare the energy consumption of Twisted File (TF instrument used with rotary or adaptive motion (AM. Materials and Methods: Forty S-shaped Endo Training Blocks (Dentsply Maillefer were used. Twenty were prepared using TF 25.06 in rotary motion (RM group, and 20 were prepared using TF Adaptive SM2 in AM group. While engine-driven endodontic motors were connected to a digital wattmeter, the required torque for root canal instrumentation was analyzed by evaluating the electrical power consumption of the endodontic engine. Electric power consumption (mW/h, elapsed time (s, and a number of pecking motions required to reach the full working length (WL were calculated. The data was statistically analyzed using Mann-Whitney U-test (P < 0.05. Results: Electrical power consumption during the preparation was significantly different between the groups; RM group exerted less electric power than reciprocating AM group did (P < 0.001. The required time to reach the full WL was not statistically significant between groups (P = 0.137. Conclusion: Within the limitation of this study, RM group exerted less electric power than reciprocating AM group did.
The Super Locally Twisted Cube Interconnection Networks and Their Properties%超级局部扭立方体互连网络及其性质
Institute of Scientific and Technical Information of China (English)
王喜; 樊建席; 韩月娟; 周吴军; 张书奎
2012-01-01
局部扭立方体是近年来提出的超立方体的一个变型,由于它的许多优越性质(如低直径),在并行处理领域越来越受到人们的重视.然而,像超立方体一样,它也有一个缺点,即要使局部扭立方体升级,就必须成倍地增加其顶点个数.为了解决这一问题,文中将顶点个数为2的次幂的局部扭立方体推广到具有任意个顶点的互连网络,提出了超级局部扭立方体(SLTC)的定义,并证明它保持了局部扭立方体的最高连通度、对数级的直径和顶点度数、Hamilton性质等方面的优良性质,从而证明了超级局部扭立方体是既保持了局部扭立方体的多种优越性质又易于升级的互连网络.%The recently introduced interconnection network, the locally twisted cube, has attracted much attention in the parallel processing area due to its many attractive features, for example: the diameter of the locally twisted cube is approximately half that of the hypercube. However, like the hypercube, it is necessary to double the node number to upgrade the locally twisted cube. In order to solve the problem, this paper generalizes the locally twisted cube with node number of power 2 to the interconnection network with arbitrary node number, and proposes a definition of the super locally twisted cube (SLTC). We prove that, the super locally twisted cube has the greatest connectivity, the logarithm node degree and diameter, and the Hamilton property. Thus, it is proved that the super locally twisted cubes are a kind of interconnection networks which keep the advantageous properties of locally twisted cubes and are easy to be upgraded.
Determination of the topological charge of a twisted beam with a Fresnel bi-prism
Emile, Olivier; Emile, Janine; Brousseau, Christian
2014-12-01
The self-interference pattern of a Laguerre Gaussian beam using a Fresnel bi-prism is shown to be very different from what could be expected from a usual laser beam. It resembles the interference pattern that could be obtained using a double slit experiment. The interferences are shifted and the topological charge and its sign can be readily determined considering the shift order of the pattern only. However, since there is no diffraction nor absorption losses unlike in a double slit interference, such a set up could be used even for low power twisted beams or beams with high topological charge. Even fractional topological charges could be determined with an absolute precision of 0.05.
Energy Technology Data Exchange (ETDEWEB)
Dacles-Mariani, J; Rodrigue, G
2005-05-11
We study the effects of macroscopic bends and twists in an optical waveguide and how they influence the transmission capabilities of a waveguide. These mechanical stresses and strains distort the optical indicatrix of the medium producing optical anisotropy. The spatially varying refractive indices are incorporated into the full-wave Maxwell's equations. The governing equations are discretized using a vector finite element method cast in a high-order finite element approximation. This approach allows us to study the complexities of the mechanical deformation within a framework of a high-order formulation which can in turn, reduce the computational requirement without degrading its performance. The optical activities generated, total energy produced and power loss due to the mechanical stresses and strains are reported and discussed.
Selection of Twist and Chord Distribution of Horizontal Axis Wind Turbine in Low Wind Conditions
Purusothaman, M.; Valarmathi, T. N.; Praneeth Reddy, S.
2016-09-01
India has a vast source of renewable energy sector, in that wind energy contributes a major role. The required source of wind energy in India cannot be able to attain maximum generation due to the operation wind turbine under European atmospheric condition. There is a need to optimize blade profiles which should be suited for low wind condition (India) that leads to increase in coefficient of performance. The present works varying of blade profiles taken in root, mid and tip section of blades are evaluated. According to properties of blade element momentum theory (BEMT) and computational work are developed for getting power curves for varying parameters such as tip speed ratio, lift and drag coefficient and main parameters like chord and twist distribution.
Noncommutative connections on bimodules and Drinfeld twist deformation
Aschieri, Paolo
2012-01-01
Given a Hopf algebra H, we study modules and bimodules over an algebra A that carry an H-action, as well as their morphisms and connections. Bimodules naturally arise when considering noncommutative analogues of tensor bundles. For quasitriangular Hopf algebras and bimodules with an extra quasi-commutativity property we induce connections on the tensor product over A of two bimodules from connections on the individual bimodules. This construction applies to arbitrary connections, i.e. not necessarily H-equivariant ones, and further extends to the tensor algebra generated by a bimodule and its dual. Examples of these noncommutative structures arise in deformation quantization via Drinfeld twists of the commutative differential geometry of a smooth manifold, where the Hopf algebra H is the universal enveloping algebra of vector fields (or a finitely generated Hopf subalgebra). We extend the Drinfeld twist deformation theory of modules and algebras to morphisms and connections that are not necessarily H-equivari...
Deformations of Fell bundles and twisted graph algebras
Raeburn, Iain
2016-11-01
We consider Fell bundles over discrete groups, and the C*-algebra which is universal for representations of the bundle. We define deformations of Fell bundles, which are new Fell bundles with the same underlying Banach bundle but with the multiplication deformed by a two-cocycle on the group. Every graph algebra can be viewed as the C*-algebra of a Fell bundle, and there are are many cocycles of interest with which to deform them. We thus obtain many of the twisted graph algebras of Kumjian, Pask and Sims. We demonstate the utility of our approach to these twisted graph algebras by proving that the deformations associated to different cocycles can be assembled as the fibres of a C*-bundle.
Geometry of quantum group twists, multidimensional Jackson calculus and regularization
Demichev, A P
1995-01-01
We show that R-matricies of all simple quantum groups have the properties which permit to present quantum group twists as transitions to other coordinate frames on quantum spaces. This implies physical equivalence of field theories invariant with respect to q-groups (considered as q-deformed space-time groups of transformations) connected with each other by the twists. Taking into account this freedom we study quantum spaces of the special type: with commuting coordinates but with q-deformed differential calculus and construct GL_r(N) invariant multidimensional Jackson derivatives. We consider a particle and field theory on a two-dimensional q-space of this kind and come to the conclusion that only one (time-like) coordinate proved to be discretized.
Progress in the Determination of Polarized PDFs and Higher Twist
Leader, Elliot; Stamenov, Dimiter B
2007-01-01
The impact of the recent very precise CLAS and COMPASS g1/F1 data on polarized parton densities and higher twist effects is discussed. It is demonstrated that the low Q^2 CLAS data improve essentially our knowledge of higher twist corrections to the spin structure function g1, while the large Q^2 COMPASS data influence mainly the strange quark and gluon polarizations. It is also shown that the uncertainties in the determination of the polarized parton densities are significantly reduced. We find also that the present inclusive DIS data cannot rule out a negative polarized and changing in sign gluon densities. The present status of the proton spin sum rule is discussed.
Sweep-twist adaptive rotor blade : final project report.
Energy Technology Data Exchange (ETDEWEB)
Ashwill, Thomas D.
2010-02-01
Knight & Carver was contracted by Sandia National Laboratories to develop a Sweep Twist Adaptive Rotor (STAR) blade that reduced operating loads, thereby allowing a larger, more productive rotor. The blade design used outer blade sweep to create twist coupling without angled fiber. Knight & Carver successfully designed, fabricated, tested and evaluated STAR prototype blades. Through laboratory and field tests, Knight & Carver showed the STAR blade met the engineering design criteria and economic goals for the program. A STAR prototype was successfully tested in Tehachapi during 2008 and a large data set was collected to support engineering and commercial development of the technology. This report documents the methodology used to develop the STAR blade design and reviews the approach used for laboratory and field testing. The effort demonstrated that STAR technology can provide significantly greater energy capture without higher operating loads on the turbine.
Twisted inhomogeneous Diophantine approximation and badly approximable sets
Harrap, Stephen
2010-01-01
For any real pair i, j geq 0 with i+j=1 let Bad(i, j) denote the set of (i, j)-badly approximable pairs. That is, Bad(i, j) consists of irrational vectors x:=(x_1, x_2) in R^2 for which there exists a positive constant c(x) such that max {||qx_1||^(-i), ||qx_2||^(-j)} > c(x)/q for all q in N. Building on a result of Kurzweil, a new characterization of the set Bad(i, j) in terms of `well-approximable' vectors in the area of `twisted' inhomogeneous Diophantine approximation is established. In addition, it is shown that Bad^x(i, j), the `twisted' inhomogeneous analogue of Bad(i, j), has full Hausdorff dimension 2 when x is chosen from the set Bad(i, j).
Noncommutative fields and actions of twisted Poincaré algebra
Chaichian, M.; Kulish, P. P.; Tureanu, A.; Zhang, R. B.; Zhang, Xiao
2008-04-01
Within the context of the twisted Poincaré algebra, there exists no noncommutative analog of the Minkowski space interpreted as the homogeneous space of the Poincaré group quotiented by the Lorentz group. The usual definition of commutative classical fields as sections of associated vector bundles on the homogeneous space does not generalize to the noncommutative setting, and the twisted Poincaré algebra does not act on noncommutative fields in a canonical way. We make a tentative proposal for the definition of noncommutative classical fields of any spin over the Moyal space, which has the desired representation theoretical properties. We also suggest a way to search for noncommutative Minkowski spaces suitable for studying noncommutative field theory with deformed Poincaré symmetries.
Noncommutative fields and actions of twisted Poincare algebra
Chaichian, M; Tureanu, A; Zhang, R B; Zhang, Xiao
2007-01-01
Within the context of the twisted Poincar\\'e algebra, there exists no noncommutative analogue of the Minkowski space interpreted as the homogeneous space of the Poincar\\'e group quotiented by the Lorentz group. The usual definition of commutative classical fields as sections of associated vector bundles on the homogeneous space does not generalise to the noncommutative setting, and the twisted Poincar\\'e algebra does not act on noncommutative fields in a canonical way. We make a tentative proposal for the definition of noncommutative classical fields of any spin over the Moyal space, which has the desired representation theoretical properties. We also suggest a way to search for noncommutative Minkowski spaces suitable for studying noncommutative field theory with deformed Poincar\\'e symmetries.
Generalized Rogers-Ramanujan identities for twisted affine algebras
Genish, Arel; Gepner, Doron
2017-07-01
The characters of parafermionic conformal field theories are given by the string functions of affine algebras, which are either twisted or untwisted algebras. Expressions for these characters as generalized Rogers-Ramanujan algebras have been established for the untwisted affine algebras. However, we study the identities for the string functions of the twisted affine Lie algebras. A conjecture for the string functions was proposed by Hatayama et al., for the unit fields, which expresses the string functions as Rogers-Ramanujan type sums. Here we propose to check the Hatayama et al. conjecture, using Lie algebraic theoretic methods. We use Freudenthal’s formula, which we computerized, to verify the identities for all the algebras at low rank and low level. We find complete agreement with the conjecture.
Higher twist effects in DIS: an outline of diquark contributions
Energy Technology Data Exchange (ETDEWEB)
Anselmino, M. [Turin Univ. (Italy). Dipt. di Fisica Teorica]|[Istituto Nazionale di Fisica Nucleare, Turin (Italy); Caruso, F. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)]|[Universidade do Estado, Rio de Janeiro, RJ (Brazil). Inst. de Fisica
1996-12-01
A quark-diquark picture of the nucleon, previously introduced in the description of a several exclusive and inclusive processes at intermediate Q{sup 2} values, is found to accurately model the higher-twist data on the unpolarized proton structure function F{sub 2}{sup p}(x,Q{sup 2}). The main results of the model are summarized. The emerging set of parameters is consistent with the diquark properties suggested by other experimental and theoretical analyses. Higher-twist corrections to the Bjorken and Gottfried sum rule are also estimated in the framework of the same quark-diquark model. The resulting corrections to both sum rules turn out to be negligible. (author). 23 refs.; Contribution to the Diquark III Conference, Torino, Italy.
On Signatures of Twisted Magnetic Flux Tube Emergence
Dominguez, Santiago Vargas; Green, Lucie; van Driel-Gesztelyi, Lidia; Hood, Alan
2011-01-01
Recent studies of NOAA active region 10953, by Okamoto {\\it et al.} ({\\it Astrophys. J. Lett.} {\\bf 673}, 215, 2008; {\\it Astrophys. J.} {\\bf 697}, 913, 2009), have interpreted photospheric observations of changing widths of the polarities and reversal of the horizontal magnetic field component as signatures of the emergence of a twisted flux tube within the active region and along its internal polarity inversion line (PIL). A filament is observed along the PIL and the active region is assumed to have an arcade structure. To investigate this scenario, MacTaggart and Hood ({\\it Astrophys. J. Lett.} {\\bf 716}, 219, 2010) constructed a dynamic flux emergence model of a twisted cylinder emerging into an overlying arcade. The photospheric signatures observed by Okamoto {\\it et al.} (2008, 2009) are present in the model although their underlying physical mechanisms differ. The model also produces two additional signatures that can be verified by the observations. The first is an increase in the unsigned magnetic fl...
Twisted optical metamaterials for planarized ultrathin broadband circular polarizers.
Zhao, Y; Belkin, M A; Alù, A
2012-05-29
Optical metamaterials are usually based on planarized, complex-shaped, resonant nano-inclusions. Three-dimensional geometries may provide a wider set of functionalities, including broadband chirality to manipulate circular polarization at the nanoscale, but their fabrication becomes challenging as their dimensions get smaller. Here we introduce a new paradigm for the realization of optical metamaterials, showing that three-dimensional effects may be obtained without complicated inclusions, but instead by tailoring the relative orientation within the lattice. We apply this concept to realize planarized, broadband bianisotropic metamaterials as stacked nanorod arrays with a tailored rotational twist. Because of the coupling among closely spaced twisted plasmonic metasurfaces, metamaterials realized with conventional lithography may effectively operate as three-dimensional helical structures with broadband bianisotropic optical response. The proposed concept is also shown to relax alignment requirements common in three-dimensional metamaterial designs. The realized sample constitutes an ultrathin, broadband circular polarizer that may be directly integrated within nanophotonic systems.
Twist-three at five loops, Bethe Ansatz and wrapping
Beccaria, M; Lukowski, T; Zieme, S
2009-01-01
We present a formula for the five-loop anomalous dimension of N=4 SYM twist-three operators in the sl(2) sector. We obtain its asymptotic part from the Bethe Ansatz and finite volume corrections from the generalized Luescher formalism, considering scattering processes of spin chain magnons with virtual particles that travel along the cylinder. The complete result respects the expected large spin scaling properties and passes non-trivial tests including reciprocity constraints. We analyze the pole structure and find agreement with a conjectured resummation formula. In analogy with the twist-two anomalous dimension at four-loops, wrapping effects are of order log^2 M/M^2 for large values of the spin.
Green functions and twist correlators for $N$ branes at angles
Pesando, Igor
2012-01-01
We compute the Green functions and correlator functions for N twist fields for branes at angles on T^2 and we show that there are N-2 different configurations labeled by an integer M which is roughly associated with the number of obtuse angles of the configuration. In order to perform this computation we use a SL(2,R) invariant formulation and geometric constraints instead of Pochammer contours. In particular the M=1 or M=N-1 amplitude can be expressed without using transcendental functions. We determine the amplitudes normalization from N -> N-1 reduction without using the factorization into the untwisted sector. Both the amplitudes normalization and the OPE of two twist fields are unique (up to one constant) when the \\epsilon 1-\\epsilon symmetry is imposed. For consistency we find also an infinite number of relations among Lauricella hypergeometric functions.
A twisted generalization of Lie-Yamaguti algebras
Gaparayi, Donatien
2010-01-01
A twisted generalization of Lie-Yamaguti algebras, called Hom-Lie-Yamaguti algebras, is defined. Hom-Lie-Yamaguti algebras generalize Hom-Lie triple systems (and susequently ternary Hom-Nambu algebras) and Hom-Lie algebras in the same way as Lie-Yamaguti algebras generalize Lie triple systems and Lie algebras. It is shown that the category of Hom-Lie-Yamaguti algebras is closed under twisting by self-morphisms. Constructions of Hom-Lie-Yamaguti algebras from classical Lie-Yamaguti algebras and Malcev algebras are given. It is observed that, when the ternary operation of a Hom-Lie-Yamaguti algebra expresses through its binary one in a specific way, then such a Hom-Lie-Yamaguti algebra is a Hom-Malcev algebra.
Evolution of chirality-odd twist-3 fragmentation functions
Ma, J. P.; Zhang, G. P.
2017-09-01
We derive the complete set of evolutions of chirality-odd twist-3 fragmentation functions at one-loop level. There are totally nine real twist-3 fragmentation functions, among which seven are independent. The renormalization-scale dependence of the nine functions has an important implication for studies of single transverse-spin asymmetries. We find that the evolutions of the three complex fragmentation functions defined by quark-gluon-quark operator are mixed with themselves. There is no mixing with the fragmentation functions defined only with bilinear quark field operators. In the large-Nc limit the evolutions of the three complex fragmentation functions are simplified and reduced to six homogeneous equations.