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Sample records for twisted envelope structure

  1. Twisting cracks in Bouligand structures.

    Science.gov (United States)

    Suksangpanya, Nobphadon; Yaraghi, Nicholas A; Kisailus, David; Zavattieri, Pablo

    2017-06-10

    The Bouligand structure, which is found in many biological materials, is a hierarchical architecture that features uniaxial fiber layers assembled periodically into a helicoidal pattern. Many studies have highlighted the high damage-resistant performance of natural and biomimetic Bouligand structures. One particular species that utilizes the Bouligand structure to achieve outstanding mechanical performance is the smashing Mantis Shrimp, Odontodactylus Scyllarus (or stomatopod). The mantis shrimp generates high speed, high acceleration blows using its raptorial appendage to defeat highly armored preys. The load-bearing part of this appendage, the dactyl club, contains an interior region [16] that consists of a Bouligand structure. This region is capable of developing a significant amount of nested twisting microcracks without exhibiting catastrophic failure. The development and propagation of these microcracks are a source of energy dissipation and stress relaxation that ultimately contributes to the remarkable damage tolerance properties of the dactyl club. We develop a theoretical model to provide additional insights into the local stress intensity factors at the crack front of twisting cracks formed within the Bouligand structure. Our results reveal that changes in the local fracture mode at the crack front leads to a reduction of the local strain energy release rate, hence, increasing the necessary applied energy release rate to propagate the crack, which is quantified by the local toughening factor. Ancillary 3D simulations of the asymptotic crack front field were carried out using a J-integral to validate the theoretical values of the energy release rate and the local stress intensity factors. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Structure of twisted and buckled bilayer graphene

    Science.gov (United States)

    Jain, Sandeep K.; Juričić, Vladimir; Barkema, Gerard T.

    2017-03-01

    We study the atomic structure of twisted bilayer graphene, with very small mismatch angles (θ ∼ {0.28}0), a topic of intense recent interest. We use simulations, in which we combine a recently presented semi-empirical potential for single-layer graphene, with a new term for out-of-plane deformations, (Jain et al 2015 J. Phys. Chem. C 119 9646) and an often-used interlayer potential (Kolmogorov et al 2005 Phys. Rev. B 71 235415). This combination of potentials is computationally cheap but accurate and precise at the same time, allowing us to study very large samples, which is necessary to reach very small mismatch angles in periodic samples. By performing large scale atomistic simulations, we show that the vortices appearing in the Moiré pattern in the twisted bilayer graphene samples converge to a constant size in the thermodynamic limit. Furthermore, the well known sinusoidal behavior of energy no longer persists once the misorientation angle becomes very small (θ \\lt {1}0). We also show that there is a significant buckling after the relaxation in the samples, with the buckling height proportional to the system size. These structural properties have direct consequences on the electronic and optical properties of bilayer graphene.

  3. Structure of the Enveloping Algebras

    Directory of Open Access Journals (Sweden)

    Č. Burdík

    2007-01-01

    Full Text Available The adjoint representations of several small dimensional Lie algebras  on their universal enveloping algebras  are explicitly decomposed. It is shown that commutants of raising operators are generated as polynomials in several basic elements. The explicit form of these elements is given and the general method for obtaining  these elements is described. 

  4. Twist decomposition of proton structure from BFKL and BK amplitudes

    CERN Document Server

    Motyka, Leszek

    2014-01-01

    An analysis of twist composition of Balitsky-Kovchegov (BK) amplitude is performed in the double logarithmic limit. In this limit the BK evolution of color dipole -- proton scattering is equivalent to BFKL evolution which follows from vanishing of the Bartels vertex in the collinear limit. We perform twist decomposition of the BFKL/BK amplitude for proton structure functions and find compact analytic expressions that provide accurate approximations for higher twist amplitudes. The BFKL/BK higher twist amplitudes are much smaller than those following from eikonal saturation models.

  5. Morphologically complex protostellar envelopes : structure and kinematics

    Science.gov (United States)

    Tobin, John J.

    I present an in-depth study of protostars and their surrounding envelopes of dense gas and dust, using a multitude of observational methods to reveal new details of the star formation process. I use mid-infrared imaging from the Spitzer Space Telescope, combined with photometry spanning the near-infrared to millimeter wavelengths, to construct a model of the L1527 protostellar system. I modeled both the spectral energy distribution and resolved scattered light images to determine physical properties of the protostellar system. The nature of the apparent central point source in the Spitzer images was uncertain until high-resolution L-band imaging from the Gemini observatory resolved the point source into a disk in scattered light, having a radius of 200 AU. Protostellar envelopes are also often found to cast shadows against the 8 micron Galactic background in Spitzer imaging, enabling direct probes of envelope structure. The shadow images show that the dense envelopes around twenty-two Class 0 protostars are generally morphologically complex from 0.1 pc scales down to ˜1000 AU; they are often filamentary, and frequently non-axisymmetric. The observed envelope structure indicates a likely origin in turbulent cloud structure rather than a quasi-static/equilibrium formation. The complex envelope structure also may indicate an increased likelihood of fragmentation during collapse, forming close binaries. To further characterize these envelopes, I have observed them in the dense molecular gas tracers nthp and nht, both of which closely follow the 8 micron extinction morphology. The magnitude of the velocity gradients and envelope complexity on ˜10000 AU scales indicates that the velocity structure may reflect large-scale infall in addition to the often assumed rotation. Comparisons with three-dimensional filamentary and symmetric rotating collapse models reinforce the interpretation of velocities reflecting large-scale infall, showing that the structure of the envelope

  6. Twist decomposition of Drell-Yan structure functions: phenomenological implications

    Science.gov (United States)

    Brzemiński, Dawid; Motyka, Leszek; Sadzikowski, Mariusz; Stebel, Tomasz

    2017-01-01

    The forward Drell-Yan process in pp scattering at the LHC at √{S} = 14 TeV is considered. We analyze the Drell-Yan structure functions assuming the dominance of a Compton-like emission of a virtual photon from a fast quark scattering off the small x gluons. The color dipole framework is applied to perform quantitatively the twist decomposition of all the Drell-Yan structure functions. Two models of the color dipole scattering are applied: the Golec-Biernat-Wüsthoff model and the dipole cross section obtained from the Balitsky-Fadin-Kuraev-Lipatov evolution equation. The two models have essentially different higher twist content and the gluon transverse momentum distribution and lead to different significant effects beyond the collinear leading twist description. It is found that the gluon transverse momentum effects are significant in the Drell-Yan structure functions for all Drell-Yan pair masses M, and the higher twist effects become important for M ≲ 10GeV. It is found that the structure function W TT related to the A 2 angular coefficient and the Lam-Tung observable A 0 - A 2 are particularly sensitive to the gluon k T effects and to the higher twist effects. A procedure is suggested how to disentangle the higher twist effects from the gluon transverse momentum effects.

  7. Twist-joints and double twist-joints in RNA structure.

    Science.gov (United States)

    Boutorine, Yury I; Steinberg, Sergey V

    2012-12-01

    Analysis of available RNA crystal structures has allowed us to identify a new family of RNA arrangements that we call double twist-joints, or DTJs. Each DTJ is composed of a double helix that contains two bulges incorporated into different strands and separated from each other by 2 or 3 bp. At each bulge, the double helix is over-twisted, while the unpaired nucleotides of both bulges form a complex network of stacking and hydrogen-bonding with nucleotides of helical regions. In total, we identified 14 DTJ cases, which can be combined in three groups based on common structural characteristics. One DTJ is found in a functional center of the ribosome, another DTJ mediates binding of the pre-tRNA to the RNase P, and two more DTJs form the sensing domains in the glycine riboswitch.

  8. Interfacial Atomic Structure of Twisted Few-Layer Graphene.

    Science.gov (United States)

    Ishikawa, Ryo; Lugg, Nathan R; Inoue, Kazutoshi; Sawada, Hidetaka; Taniguchi, Takashi; Shibata, Naoya; Ikuhara, Yuichi

    2016-02-18

    A twist in bi- or few-layer graphene breaks the local symmetry, introducing a number of intriguing physical properties such as opening new bandgaps. Therefore, determining the twisted atomic structure is critical to understanding and controlling the functional properties of graphene. Combining low-angle annular dark-field electron microscopy with image simulations, we directly determine the atomic structure of twisted few-layer graphene in terms of a moiré superstructure which is parameterized by a single twist angle and lattice constant. This method is shown to be a powerful tool for accurately determining the atomic structure of two-dimensional materials such as graphene, even in the presence of experimental errors. Using coincidence-site-lattice and displacement-shift-complete theories, we show that the in-plane translation state between layers is not a significant structure parameter, explaining why the present method is adequate not only for bilayer graphene but also a few-layered twisted graphene.

  9. Interfacial Atomic Structure of Twisted Few-Layer Graphene

    Science.gov (United States)

    Ishikawa, Ryo; Lugg, Nathan R.; Inoue, Kazutoshi; Sawada, Hidetaka; Taniguchi, Takashi; Shibata, Naoya; Ikuhara, Yuichi

    2016-02-01

    A twist in bi- or few-layer graphene breaks the local symmetry, introducing a number of intriguing physical properties such as opening new bandgaps. Therefore, determining the twisted atomic structure is critical to understanding and controlling the functional properties of graphene. Combining low-angle annular dark-field electron microscopy with image simulations, we directly determine the atomic structure of twisted few-layer graphene in terms of a moiré superstructure which is parameterized by a single twist angle and lattice constant. This method is shown to be a powerful tool for accurately determining the atomic structure of two-dimensional materials such as graphene, even in the presence of experimental errors. Using coincidence-site-lattice and displacement-shift-complete theories, we show that the in-plane translation state between layers is not a significant structure parameter, explaining why the present method is adequate not only for bilayer graphene but also a few-layered twisted graphene.

  10. Twist decomposition of Drell-Yan structure functions: phenomenological implications

    CERN Document Server

    Brzeminski, Dawid; Sadzikowski, Mariusz; Stebel, Tomasz

    2016-01-01

    The forward Drell--Yan process in $pp$ scattering at the LHC at $\\sqrt{S}=14$ TeV is considered. We analyze the Drell--Yan structure functions assuming the dominance of a Compton-like emission of a virtual photon from a fast quark scattering off the small $x$ gluons. The color dipole framework is applied to perform quantitatively the twist decomposition of all the Drell--Yan structure functions. Two models of the color dipole scattering are applied: the Golec-Biernat--W\\"{u}sthoff model and the dipole cross section obtained from the Balitsky--Fadin--Kuraev--Lipatov evolution equation. The two models have essentially different higher twist content and the gluon transverse momentum distribution and lead to different significant effects beyond the collinear leading twist description. It is found that the gluon transverse momentum effects are significant in the Drell--Yan structure functions for all Drell--Yan pair masses $M$, and the higher twist effects become important for $M \\lesssim 10$ GeV. It is found that...

  11. Twisted light

    CSIR Research Space (South Africa)

    Forbes, A

    2010-12-01

    Full Text Available Research at the Mathematical Optics Group uses "twisted" light to study new quatum-based information security systems. In order to understand the structure of "twisted" light, it is useful to start with an ordinary light beam with zero twist, namely...

  12. PHASE STRUCTURE OF TWISTED EGUCHI-KAWAI MODEL.

    Energy Technology Data Exchange (ETDEWEB)

    ISHIKAWA,T.; AZEYANAGI, T.; HANADA, M.; HIRATA, T.

    2007-07-30

    We study the phase structure of the four-dimensional twisted Eguchi-Kawai model using numerical simulations. This model is an effective tool for studying SU(N) gauge theory in the large-N limit and provides a nonperturbative formulation of the gauge theory on noncommutative spaces. Recently it was found that its Z{sub n}{sup 4} symmetry, which is crucial for the validity of this model, can break spontaneously in the intermediate coupling region. We investigate in detail the symmetry breaking point from the weak coupling side. Our simulation results show that the continuum limit of this model cannot be taken.

  13. Structural plasticity of the nuclear envelope and the endoplasmic reticulum

    Directory of Open Access Journals (Sweden)

    Sheval E. V.

    2014-09-01

    Full Text Available The nuclear envelope is a double membrane structure, continuous with endoplasmic reticulum, and the morphological organization of both these structures is quite conservative. However, nuclear envelope and endoplasmic reticulum demonstrate distinct structural plasticity, i. e., based on common organization, cells may form various non-canonical membrane structures that are observed only in specialized types of cells or appear in different pathologies. In this review, we will discuss the mechanisms of the biogenesis of such non-canonical structures, and the possible role of this plasticity in the development of pathological processes.

  14. Hymenolepis nana: the fine structure of the embryonic envelopes.

    Science.gov (United States)

    Fairweather, I; Threadgold, L T

    1981-06-01

    The fine structure of the envelopes surrounding hatched and unhatched oncospheres of Hymenolepis nana has been investigated by transmission and scanning electron microscopy (SEM), together with light microscope histochemical observations of JB-4 embedded material. The oncosphere is surrounded by 3 layers--the capsule, the outer envelope and the inner envelope, the latter giving rise to the embryophore and the 'oncospheral membrane'. An additional layer--the polar filament layer--lies between the 'oncospheral membrane' and the oncosphere. Shell material is deposited on the capsule as a thin layer. It is secreted by the outer envelope, which degenerates once shell formation is complete. The uterus may also contribute to shell formation. The embryophore forms a thin incomplete and peripheral layer within the inner envelope. In the basal region of this envelope, partial development of an 'oncospheral membrane' takes place, but it does not become detached as a separate layer. The polar filaments, which are characteristic of the oncosphere of H. nana, are derived from the epithelial covering of the oncosphere itself, which delaminates to form a separate polar filament layer. The filaments arise from knob-like projections at opposite poles of this layer. The design of the embryonic envelopes in H. nana show a number of modifications from the basic cyclophyllidean pattern, and these can be related to the demands of its 'direct' life-cycle.

  15. Monitoring the bending and twist of morphing structures

    Science.gov (United States)

    Smoker, J.; Baz, A.

    2008-03-01

    This paper presents the development of the theoretical basis for the design of sensor networks for determining the 2-dimensioal shape of morphing structures by monitoring simultaneously the bending and twist deflections. The proposed development is based on the non-linear theory of finite elements to extract the transverse linear and angular deflections of a plate-like structure. The sensors outputs are wirelessly transmitted to the command unit to simultaneously compute maps of the linear and angular deflections and maps of the strain distribution of the entire structure. The deflection and shape information are required to ascertain that the structure is properly deployed and that its surfaces are operating wrinkle-free. The strain map ensures that the structure is not loaded excessively to adversely affect its service life. The developed theoretical model is validated experimentally using a prototype of a variable cambered span morphing structure provided with a network of distributed sensors. The structure/sensor network system is tested under various static conditions to determine the response characteristics of the proposed sensor network as compared to other conventional sensor systems. The presented theoretical and experimental techniques can have a great impact on the safe deployment and effective operation of a wide variety of morphing and inflatable structures such as morphing aircraft, solar sails, inflatable wings, and large antennas.

  16. Characterizing twist grain boundaries in BCC Nb by molecular simulation: Structure and shear deformation

    Science.gov (United States)

    Liu, Zeng-Hui; Feng, Ya-Xin; Shang, Jia-Xiang

    2016-05-01

    Atomic scale modeling was used to study the structure, energy and shear behaviors of (110) twist grain boundaries (TWGBs) in body-centered cubic Nb. The relation between grain boundary energy (GBE) and the twist angle θ agrees well with the Read-Shockley equation in low-angle range. At higher angles, the GBEs show no distinct trend with the variation of the twist angle or the density of coincident lattice sites. All (110) twist boundaries can be classified into two types: low-angle grain boundaries (LAGBs) and high-angle grain boundaries (HAGBs). LAGBs contain a hexagonal dislocation network (HDN) which is composed of 1/2 [ 111 ], 1/2 [ 1 bar 1 bar 1 ] and [001] screw dislocations. HAGBs can be classified into three sub-types further: special boundaries with low Σ, boundaries in the vicinity of special boundaries with similar structures and ordinary HAGBs consisting of periodic patterns. Besides, a dependence of grain boundary shear response vs the twist angle over the entire twist angle range is obtained. Pure sliding behavior is found at all TWGBs. When θ < 12°, the flow stress of LAGBs is found to be correlated with the HDNs and decreases with the increasing twist angle. For ordinary HAGBs, the magnitude of flow stress is around 0.8-1.0 GPa and the twist angle has little effect on the anisotropy mobility. For special grain boundaries with low Σ, the boundary structures govern the GBEs and shear motion behavior significantly.

  17. Folded Plate Structures as Building Envelopes

    DEFF Research Database (Denmark)

    Falk, Andreas; Buelow, Peter von; Kirkegaard, Poul Henning

    2012-01-01

    This paper treats applications of cross-laminated timber (CLT) in structural systems for folded façade solutions. Previous work on CLT-based systems for folded roofs has shown a widening range of structural possibilities to develop timber-based shells. Geometric and material properties play, howe...

  18. Structure of Phage P22 Cell Envelope-Penetrating Needle

    Energy Technology Data Exchange (ETDEWEB)

    Olia, A.S.; Casjens, S.; Cingolani, G.

    2009-06-02

    Bacteriophage P22 infects Salmonella enterica by injecting its genetic material through the cell envelope. During infection, a specialized tail needle, gp26, is injected into the host, likely piercing a hole in the host cell envelope. The 2.1-{angstrom} crystal structure of gp26 reveals a 240-{angstrom} elongated protein fiber formed by two trimeric coiled-coil domains interrupted by a triple {beta}-helix. The N terminus of gp26 plugs the portal protein channel, retaining the genetic material inside the virion. The C-terminal tip of the fiber exposes {beta}-hairpins with hydrophobic tips similar to those seen in class II fusion peptides. The {alpha}-helical core connecting these two functionally polarized tips presents four trimerization octads with consensus sequence IXXLXXXV. The slender conformation of the gp26 fiber minimizes the surface exposed to solvent, which is consistent with the idea that gp26 traverses the cell envelope lipid bilayers.

  19. κ-Poincaré–Hopf algebra and Hopf algebroid structure of phase space from twist

    Energy Technology Data Exchange (ETDEWEB)

    Jurić, Tajron, E-mail: Tajron.Juric@irb.hr [Rudjer Bošković Institute, Bijenička c.54, HR-10002 Zagreb (Croatia); Meljanac, Stjepan, E-mail: meljanac@irb.hr [Rudjer Bošković Institute, Bijenička c.54, HR-10002 Zagreb (Croatia); Štrajn, Rina, E-mail: r.strajn@jacobs-university.de [Jacobs University Bremen, 28759 Bremen (Germany)

    2013-11-15

    We unify κ-Poincaré algebra and κ-Minkowski spacetime by embedding them into quantum phase space. The quantum phase space has Hopf algebroid structure to which we apply the twist in order to get κ-deformed Hopf algebroid structure and κ-deformed Heisenberg algebra. We explicitly construct κ-Poincaré–Hopf algebra and κ-Minkowski spacetime from twist. It is outlined how this construction can be extended to κ-deformed super-algebra including exterior derivative and forms. Our results are relevant for constructing physical theories on noncommutative spacetime by twisting Hopf algebroid phase space structure.

  20. Folded Plate Structures as Building Envelopes

    DEFF Research Database (Denmark)

    Falk, Andreas; Buelow, Peter von; Kirkegaard, Poul Henning

    2012-01-01

    This paper treats applications of cross-laminated timber (CLT) in structural systems for folded façade solutions. Previous work on CLT-based systems for folded roofs has shown a widening range of structural possibilities to develop timber-based shells. Geometric and material properties play......, however, an important role also for the enclosure, and climate and conceptual design procedures have been utilised to include these issues in early design phases. A current architectural trend proposes increasing complexity of the façades and in this context the paper proposes the application of folded...

  1. Investigation of Beam-RF Interactions in Twisted Waveguide Accelerating Structures Using Beam Tracking Codes

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, Jeffrey A [ORNL; Zhang, Yan [ORNL; Kang, Yoon W [ORNL; Galambos, John D [ORNL; Hassan, Mohamed H [ORNL; Wilson, Joshua L [ORNL

    2009-01-01

    Investigations of the RF properties of certain twisted waveguide structures show that they support favorable accelerating fields. This makes them potential candidates for accelerating cavities. Using the particle tracking code, ORBIT, We examine the beam - RF interaction in the twisted cavity structures to understand their beam transport and acceleration properties. The results will show the distinctive properties of these new structures for particle transport and acceleration, which have not been previously analyzed.

  2. Structured x-ray beams from twisted electrons by inverse Compton scattering of laser light

    CERN Document Server

    Seipt, D; Fritzsche, S

    2014-01-01

    The inverse Compton scattering of laser light on high-energetic twisted electrons is investigated with the aim to construct spatially structured x-ray beams. In particular, we analyze how the properties of the twisted electrons, such as the topological charge and aperture angle of the electron Bessel beam, affects the energy and angular distribution of scattered x-rays. We show that with suitably chosen initial twisted electron states one can synthesize tailor-made x-ray beam profiles with a well-defined spatial structure, in a way not possible with ordinary plane-wave electron beams.

  3. Nucleon Structure in Lattice QCD using twisted mass fermions

    CERN Document Server

    Alexandrou, C; Korzec, T; Carbonell, J; Harraud, P A; Papinutto, M; Guichon, P; Jansen, K

    2010-01-01

    We present results on the nucleon form factors and moments of generalized parton distributions obtained within the twisted mass formulation of lattice QCD. We include a discussion of lattice artifacts by examining results at different volumes and lattice spacings. We compare our results with those obtained using different discretization schemes and to experiment.

  4. Spin, twist and hadron structure in deep inelastic processes

    CERN Document Server

    Jaffe, R L

    1997-01-01

    These notes provide an introduction to polarization effects in deep inelastic processes in QCD. We emphasize recent work on transverse asymmetries, subdominant effects, and the role of polarization in fragmentation and in purely hadronic processes. After a review of kinematics and some basic tools of short distance analysis, we study the twist, helicity, chirality and transversity dependence of a variety of high energy processes sensitive to the quark and gluon substructure of hadrons.

  5. Crystal Structure of the Japanese Encephalitis Virus Envelope Protein

    Energy Technology Data Exchange (ETDEWEB)

    Luca, Vincent C.; AbiMansour, Jad; Nelson, Christopher A.; Fremont, Daved H. (WU-MED)

    2012-03-13

    Japanese encephalitis virus (JEV) is the leading global cause of viral encephalitis. The JEV envelope protein (E) facilitates cellular attachment and membrane fusion and is the primary target of neutralizing antibodies. We have determined the 2.1-{angstrom} resolution crystal structure of the JEV E ectodomain refolded from bacterial inclusion bodies. The E protein possesses the three domains characteristic of flavivirus envelopes and epitope mapping of neutralizing antibodies onto the structure reveals determinants that correspond to the domain I lateral ridge, fusion loop, domain III lateral ridge, and domain I-II hinge. While monomeric in solution, JEV E assembles as an antiparallel dimer in the crystal lattice organized in a highly similar fashion as seen in cryo-electron microscopy models of mature flavivirus virions. The dimer interface, however, is remarkably small and lacks many of the domain II contacts observed in other flavivirus E homodimers. In addition, uniquely conserved histidines within the JEV serocomplex suggest that pH-mediated structural transitions may be aided by lateral interactions outside the dimer interface in the icosahedral virion. Our results suggest that variation in dimer structure and stability may significantly influence the assembly, receptor interaction, and uncoating of virions.

  6. Twisted X-rays: incoming waveforms yielding discrete diffraction patterns for helical structures

    CERN Document Server

    Friesecke, Gero; Jüstel, Dominik

    2015-01-01

    Conventional X-ray methods use incoming plane waves and result in discrete diffraction patterns when scattered at crystals. Here we find, by a systematic method, incoming waveforms which exhibit discrete diffraction patterns when scattered at helical structures. As examples we present simulated diffraction patterns of carbon nanotubes and tobacco mosaic virus. The new incoming waveforms, which we call twisted waves due to their geometric shape, are found theoretically as closed-form solutions to Maxwell's equations. The theory of the ensuing diffraction patterns is developed in detail. A twisted analogue of the Von Laue condition is seen to hold, with the peak locations encoding the symmetry and the helix parameters, and the peak intensities indicating the electronic structure in the unit cell. If suitable twisted X-ray sources can in the future be realized experimentally, it appears from our mathematical results that they will provide a powerful tool for directly determining the detailed atomic structure of ...

  7. Structure of the Epstein-Barr virus major envelope glycoprotein.

    Science.gov (United States)

    Szakonyi, Gerda; Klein, Michael G; Hannan, Jonathan P; Young, Kendra A; Ma, Runlin Z; Asokan, Rengasamy; Holers, V Michael; Chen, Xiaojiang S

    2006-11-01

    Epstein-Barr virus (EBV) infection of B cells is associated with lymphoma and other human cancers. EBV infection is initiated by the binding of the viral envelope glycoprotein (gp350) to the cell surface receptor CR2. We determined the X-ray structure of the highly glycosylated gp350 and defined the CR2 binding site on gp350. Polyglycans shield all but one surface of the gp350 polypeptide, and we demonstrate that this glycan-free surface is the receptor-binding site. Deglycosylated gp350 bound CR2 similarly to the glycosylated form, suggesting that glycosylation is not important for receptor binding. Structure-guided mutagenesis of the glycan-free surface disrupted receptor binding as well as binding by a gp350 monoclonal antibody, a known inhibitor of virus-receptor interactions. These results provide structural information for developing drugs and vaccines to prevent infection by EBV and related viruses.

  8. Twisted derivations of Hopf algebras

    CERN Document Server

    Davydov, Alexei

    2012-01-01

    In the paper we introduce the notion of twisted derivation of a bialgebra. Twisted derivations appear as infinitesimal symmetries of the category of representations. More precisely they are infinitesimal versions of twisted automorphisms of bialgebras. Twisted derivations naturally form a Lie algebra (the tangent algebra of the group of twisted automorphisms). Moreover this Lie algebra fits into a crossed module (tangent to the crossed module of twisted automorphisms). Here we calculate this crossed module for universal enveloping algebras and for the Sweedler's Hopf algebra.

  9. Investigation of structural behaviour due to bend-twist couplings in wind turbine blades

    DEFF Research Database (Denmark)

    Fedorov, Vladimir; Dimitrov, Nikolay Krasimiroy; Berggreen, Christian;

    2009-01-01

    The structural behaviour of a composite wind turbine blade with implemented bend-twist coupling is examined in this paper. Several shell finite element models of the blade have been developed and validated against full-scale tests. All shell models performed well for flap-wise bending, but perfor......The structural behaviour of a composite wind turbine blade with implemented bend-twist coupling is examined in this paper. Several shell finite element models of the blade have been developed and validated against full-scale tests. All shell models performed well for flap-wise bending...

  10. Synthesis and structural determination of twisted MoS{sub 2} nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Santiago, P.; Schabes-Retchkiman, P. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 20-364, 01000, Mexico, D.F. (Mexico); Ascencio, J.A. [Instituto Mexicano del Petroleo, Eje Central Lazaro Cardenas 152, C.P. 07730, Mexico, D.F., Col. San Bartolo Atepehuacan (Mexico); Facultad de Quimica, Universidad Autonoma del Estado de Mexico, Paseo Colon esq. Paseo Tollocan, Apartado Postal A-20, C.P. 50120, Toluca (Mexico); Mendoza, D. [Instituto de Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-360, 04510, Mexico, D.F. (Mexico); Perez-Alvarez, M. [Instituto Nacional de Investigaciones Nucleares, Km. 36.5 Carr, Mexico-Toluca Ocoyoacac (Mexico); Espinosa, A. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 20-364, 01000, Mexico, D.F. (Mexico); Facultad de Ciencias VAEMEX, 50000, Toloca, Edo Mex. (Mexico); Reza-SanGerman, C. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 20-364, 01000, Mexico, D.F. (Mexico); Facultad de Quimica, Universidad Autonoma del Estado de Mexico, Paseo Colon esq. Paseo Tollocan, Apartado Postal A-20, C.P. 50120, Toluca (Mexico); Instituto Nacional de Investigaciones Nucleares, Km. 36.5 Carr, Mexico-Toluca Ocoyoacac (Mexico); Camacho-Bragado, G.A. [Department of Chemical Engineering, CNM and TMI, University of Texas at Austin, 78712, Austin, TX (United States); Jose-Yacaman, M. [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 20-364, 01000, Mexico, D.F. (Mexico); Department of Chemical Engineering, CNM and TMI, University of Texas at Austin, 78712, Austin, TX (United States)

    2004-03-01

    In the present work we report the synthesis of MoS{sub 2} nanotubes with diameters greater than 10 nm using a template method. The length and properties of these nanotubes are a direct result of the preparation method. High-resolution transmission electron microscopy is used to study the structure of these highly curved entities. Molecular dynamics simulations of MoS{sub 2} nanotubes reveal that one of the stable forms of the nanotubes is a twisted one. The twisting of the nanotubes produces a characteristic contrast in the images, which is also studied using simulation methods. The analysis of the local contrast close to the perpendicular orientation shows geometrical arrays of dots in domain-like structures, which are demonstrated to be a product of the atomic overlapping of irregular curvatures in the nanotubes. The configuration of some of the experimentally obtained nanotubes is demonstrated to be twisted with a behavior suggesting partial plasticity. (orig.)

  11. Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Leopold; Giang, Erick; Nieusma, Travis; Kadam, Rameshwar U.; Cogburn, Kristin E.; Hua, Yuanzi; Dai, Xiaoping; Stanfield, Robyn L.; Burton, Dennis R.; Ward, Andrew B.; Wilson, Ian A.; Law, Mansun

    2014-08-26

    Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to broadly neutralizing antibody AR3C at 2.65 angstroms reveals a compact architecture composed of a central immunoglobulin-fold β sandwich flanked by two additional protein layers. The CD81 receptor binding site was identified by electron microscopy and site-directed mutagenesis and overlaps with the AR3C epitope. The x-ray and electron microscopy E2 structures differ markedly from predictions of an extended, three-domain, class II fusion protein fold and therefore provide valuable information for HCV drug and vaccine design.

  12. Phase structure with nonzero $\\Theta_{\\rm QCD}$ and twisted mass fermions

    CERN Document Server

    Horkel, Derek P

    2015-01-01

    We determine the phase diagram and chiral condensate for lattice QCD with two flavors of twisted-mass fermions in the presence of nondegenerate up and down quarks, discretization errors and a nonzero value of $\\Theta_{\\rm QCD}$. Although such a theory has a complex action and cannot, at present, be simulated, the results are needed to understand how to tune to maximal twist in the presence of electromagnetism, a topic discussed in a companion paper. We find that, in general, the only phase structure is a first-order transition of finite length. Pion masses are nonvanishing throughout the phase plane except at the endpoints of the first-order line. Only for extremal values of the twist angle and $\\Theta_{\\rm QCD}$ ($\\omega=0$ or $\\pi/2$ and $\\Theta_{\\rm QCD}=0$ or $\\pi$) are there second-order transitions.

  13. Breatherlike defects and their dynamics in the one-dimensional roll structure of twisted nematics

    Energy Technology Data Exchange (ETDEWEB)

    Skaldin, O. A.; Delev, V. A., E-mail: delev@anrb.ru; Shikhovtseva, E. S.; Lebedev, Yu. A.; Batyrshin, E. S. [Russian Academy of Sciences, Institute of Molecular and Crystal Physics, Ufa Research Center (Russian Federation)

    2015-12-15

    The dynamics of the nonsingular defects in the periodic structures of the rolls that appear in π/2-twisted nematic liquid crystals during electroconvection is studied experimentally and theoretically. The roll structures in twisted nematics are characterized by the presence of an axial component of the hydrodynamic flow velocity with opposite directions in neighboring rolls. The critical oscillation frequency of structural defects is quantitatively estimated using a nonlinear equation of motion for roll displacements. It is found that a pair of edge dislocations with topological charges of +1 and–1 nucleates and annihilates periodically during the oscillations of a defect with a nonsingular core. Oscillating defects with a zero topological charge is shown to correspond to the solution of the sine-Gordon equation in the form of standing breathers. Asymmetry is detected in the full oscillation cycle of a breather defect, and it is related to the twist symmetry of a twist nematic. This asymmetry is taken into account as effective anisotropic friction. The behavior of a breather on a trap, namely, a classical defect (dislocation), is investigated. Dislocation motion is shown to be anisotropic in the oscillation cycle: in one direction, a dislocation moves regularly; in the second phase, the transition into the initial state proceeds via the decay of the breather into a dipole pair of dislocations of opposite signs followed by their annihilation.

  14. Structures of Equatorial Envelope Rossby Wave Under a Generalized External Forcing

    Institute of Scientific and Technical Information of China (English)

    FU Zun-Tao; LIU Shi-Da; LIU Shi-Kuo

    2004-01-01

    The cubic nonlinear Schrodinger (NLS for short) equation with a generalized external heating source is derived for large amplitude equatorial envelope Rossby wave in a shear flow. And then various periodic structures for these equatorial envelope Rossby waves are obtained with the help of a new transformation, Jacobi elliptic functions,and elliptic equation. It is shown that different types of resonant phase-locked diabatic heating play different roles in structures of equatorial envelope Rossby wave.

  15. Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

    Directory of Open Access Journals (Sweden)

    Erin E H Tran

    Full Text Available HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development. Using cryo-electron microscopy, we describe the contrasting structural outcomes of trimeric Env binding to soluble CD4, to the broadly neutralizing, CD4-binding site antibodies VRC01, VRC03 and b12, or to the monoclonal antibody 17b, a co-receptor mimic. Binding of trimeric HIV-1 BaL Env to either soluble CD4 or 17b alone, is sufficient to trigger formation of the open quaternary conformation of Env. In contrast, VRC01 locks Env in the closed state, while b12 binding requires a partial opening in the quaternary structure of trimeric Env. Our results show that, despite general similarities in regions of the HIV-1 gp120 polypeptide that contact CD4, VRC01, VRC03 and b12, there are important differences in quaternary structures of the complexes these ligands form on native trimeric Env, and potentially explain differences in the neutralizing breadth and potency of antibodies with similar specificities. From cryo-electron microscopic analysis at ∼9 Å resolution of a cleaved, soluble version of trimeric Env, we show that a structural signature of the open Env conformation is a three-helix motif composed of α-helical segments derived from highly conserved, non-glycosylated N-terminal regions of the gp41 trimer. The three N-terminal gp41 helices in this novel, activated Env conformation are held apart by their interactions with the rest of Env, and are less compactly packed than in the post-fusion, six-helix bundle state. These findings suggest a new structural template for designing immunogens that can elicit antibodies targeting HIV at a vulnerable, pre-entry stage.

  16. Representation Theory of Quantized Enveloping Algebras with Interpolating Real Structure

    Directory of Open Access Journals (Sweden)

    Kenny De Commer

    2013-12-01

    Full Text Available Let g be a compact simple Lie algebra. We modify the quantized enveloping ∗-algebra associated to g by a real-valued character on the positive part of the root lattice. We study the ensuing Verma module theory, and the associated quotients of these modified quantized enveloping ∗-algebras. Restricting to the locally finite part by means of a natural adjoint action, we obtain in particular examples of quantum homogeneous spaces in the operator algebraic setting.

  17. Structure simulation in unidirectionally solidified turbine blade by dendrite envelope tracking model(Ⅰ): numerical modeling

    Institute of Scientific and Technical Information of China (English)

    WANG Tong-min; I. Ohnaka; H.Yasuda; SU Yan-qing; GUO Jing-jie

    2006-01-01

    A 3D dendrite envelope tracking model was developed for estimating the solidification structure of unidirectionally solidified turbine blade. The normal vector of dendrite envelope was estimated by the gradient of dendrite volume fraction, and growth velocity of the dendrite envelope (dendrite tips) was calculated with considering the anisotropy of grain growth. The solute redistribution at dendrite envelope was calculated by introducing an effective solute partition coefficient(ke). Simulation results show that the solute-build-up due to the rejection at envelope affects grain competition and consequently the solidification structure. The lower value of ke leads to more waved dendrite growth front and higher solute rejection. The model was applied to predict the structure of turbine-blade-shape samples showing good ability to reproduce the columnar and single grain structures.

  18. On the relationship between multi-channel envelope and temporal fine structure

    DEFF Research Database (Denmark)

    2011-01-01

    The envelope of a signal is broadly defined as the slow changes in time of the signal, where as the temporal fine structure (TFS) are the fast changes in time, i.e. the carrier wave(s) of the signal. The focus of this paper is on envelope and TFS in multi-channel systems. We discuss the differenc...

  19. Structural Transitions of a Twisted and Stretched DNA Molecule

    Science.gov (United States)

    Léger, J. F.; Romano, G.; Sarkar, A.; Robert, J.; Bourdieu, L.; Chatenay, D.; Marko, J. F.

    1999-08-01

    We report results of a micromanipulation study of single double-helical DNA molecules at forces up to 150 pN. Depending on whether the DNA winding is allowed to relax, or held fixed, qualitatively different structural transitions are observed. By studying the transitions as a function of winding the different DNA structures underlying them are characterized; this allows us to report the first estimate of S-DNA helicity. A model is introduced to describe these transitions; in addition to B-DNA, we find that four DNA states are needed to describe the experiments.

  20. The ionization structure of the circumstellar envelope of Alpha Orionis

    Science.gov (United States)

    Glassgold, A. E.; Huggins, P. J.

    1986-01-01

    The physical processes which affect the ionization of the outer circumstellar envelope of Alpha Ori are analyzed and evaluated. The ultraviolet radiation fields of the chromosphere and the interstellar medium dominate the envelope, and the most common forms of all species are neutral atoms and first ions. Hydrogen recombines just outside the chromosphere, where atoms with smaller ionization potential are essentially fully ionized. The heavier ions gradually recombine with increasing distance from the star, until the interstellar radiation field reverses this trend. The electron fraction in the outer envelope is approximately equal to the abundance of all such heavy atoms, i.e., of the order of 0.0001. The analysis is applied to the case of neutral K, whose density in the envelope has been determined by scattering experiments. The theory predicts that the slope of the K I density distribution should decrease from -1.5 to -3.5 in the outer envelope. The mass loss rate of Alpha Ori implied by the K I scattering experiments is 4 x 10 to the -6th solar mass/yr.

  1. Self-assembly of polypeptides into left-handedly twisted fibril-like structures

    Science.gov (United States)

    Mu, Yan; Gao, Yi Qin

    2009-10-01

    In this paper, we investigated the spontaneous formation of aggregation structures of amyloid-forming peptide (GGVVIA) using a coarse-grained model and Monte Carlo simulations. The effects of concentration and temperature on the formation of different aggregation structures were studied. Three types of aggregation structures, single-layer β sheet, amorphous β -sheet aggregate, and fibril-like structures, were observed in our simulations. The fibril-like structures obtained in simulations have a common cross- β spine structure in which β sheets twist in a left-handed fashion. The averaged twisting angle of the β sheet in the fibril-like structures is 12°±2° . Moreover, it was found that the peptides in the same β sheets prefer to arrange in a parallel way, which is consistent with the corresponding GGVVIA crystalline structure. On the other hand, it was found that there is a rich family of β -sheet stacking patterns in the fibril-like structures suggesting that the fibril structures are more complex than the corresponding crystalline structure and there exist many local free-energy minima rather than a distinct global minimum.

  2. Ab initio calculations on twisted graphene/hBN: Electronic structure and STM image simulation

    Science.gov (United States)

    Correa, J. D.; Cisternas, E.

    2016-09-01

    By performing ab initio calculations we obtained theoretical scanning tunneling microscopy (STM) images and studied the electronic properties of graphene on a hexagonal boron-nitrite (hBN) layer. Three different stack configurations and four twisted angles were considered. All calculations were performed using density functional theory, including van der Waals interactions as implemented in the SIESTA ab initio package. Our results show that the electronic structure of graphene is preserved, although some small changes are induced by the interaction with the hBN layer, particularly in the total density of states at 1.5 eV under the Fermi level. When layers present a twisted angle, the density of states shows several van Hove singularities under the Fermi level, which are associated to moiré patterns observed in theoretical STM images.

  3. The structure of protostellar envelopes derived from submillimeter continuum images

    CERN Document Server

    Chandler, C J; Chandler, Claire J.; Richer, John S.

    1999-01-01

    High dynamic range imaging of submillimeter dust emission from the envelopes of eight young protostars in the Taurus and Perseus star-forming regions has been carried out using the SCUBA submillimeter camera on the James Clerk Maxwell Telescope. Good correspondence between the spectral classifications of the protostars and the spatial distributions of their dust emission is observed, in the sense that those with cooler spectral energy distributions also have a larger fraction of the submillimeter flux originating in an extended envelope compared with a disk. This results from the cool sources having more massive envelopes rather than warm sources having larger disks. Azimuthally-averaged radial profiles of the dust emission are used to derive the power-law index of the envelope density distributions, p (defined by rho proportional to r^-p), and most of the sources are found to have values of p consistent with those predicted by models of cloud collapse. However, the youngest protostars in our sample, L1527 an...

  4. Structures of Equatorial Envelope Rossby Wave Under a Generalized External Forcing

    Institute of Scientific and Technical Information of China (English)

    FUZun-Tao; LIUShi-Da; LIUShi-Kuo

    2004-01-01

    The cubic nonlinear Schroedinger (NLS for short) equation with a generalized external heating source is derived for large amplitude equatorial envelope Rossby wave in a shear flow. And then various periodic structures for these equatorial cnvelope Rossby waves are obtained with the help of a new transformation, Jacobi elliptic functions,and elliptic equation. It is shown that different types of resonant phase-locked diabatic heating play different roles in structures of equatorial envelope Rossby wave.

  5. Case Study of Envelope Sealing in Existing Multiunit Structures

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, Jordan [ARIES Collaborative, New York, NY (United States); Conlin, Francis [ARIES Collaborative, New York, NY (United States); Podorson, David [ARIES Collaborative, New York, NY (United States)

    2012-10-01

    This report describes envelope air sealing that was included in the retrofit of a 244 unit low-rise multifamily housing complex in Durham, N.C. On average, total leakage was reduced by nearly half, from 19.7 ACH50 to 9.4 ACH50. Important air leakage locations identified included plumbing and electrical penetrations, dropped ceilings/soffits, windows, ducts and wall-to-floor intersections. Specifications and a pictorial guide were developed for contractors performing the work.

  6. Twist and temperature characteristics of the PD-NSN fiber structure based on in-line Mach-Zehnder interferometer

    Science.gov (United States)

    Dong, Yue; Sun, Chunran; Xiao, Han; Dong, Changbin; Jian, Shuisheng

    2017-01-01

    A novel polarization-dependent (PD) no core-single mode-no core (NSN) fiber structure for twist and temperature sensing has been experimentally investigated. The proposed structure simply involves a section of polarization maintain fiber sandwiched into NSN fiber structure, only using the splicing method. We have analyzed and demonstrated the transmission characteristics of the no core fiber (NCF) with the different lengths. Experimental results indicate that the extinction ratio of the PD-NSN fiber structure comb spectrum based on Mach-Zehnder interferometer (MZI) various with twist rate. The maximum sensitivity of 0.33904 dB/(rad/m) for range from -240° to 360° is achieved. The temperature sensitivity of the proposed structure reaches 41.89 pm/°C for temperature ranging from 20 to 70 °C in the experiment. By using the peak-wavelength discrimination method, the proposed sensor can overcome the temperature and twist cross-sensitivity effects.

  7. Case Study of Envelope Sealing in Existing Multiunit Structures

    Energy Technology Data Exchange (ETDEWEB)

    Dentz, J.; Conlin, F.; Podorson, D.

    2012-10-01

    Envelope air sealing was included in the retrofit of a 244 unit low-rise multifamily housing complex in Durham, N.C. Pre- and post-retrofit enclosure leakage tests were conducted on 51 units and detailed diagnostics were performed on 16. On average, total leakage was reduced by nearly half, from 19.7 ACH50 to 9.4 ACH50. Costs for air sealing were $0.31 per square foot of conditioned floor area, lower than estimates found in the National Residential Efficiency Measures Database (NREMD) and other sources, perhaps due in part to the large-scale production nature of the project. Modeling with BEopt software -- using an estimate of 85% of the envelope air leakage going to the outside (based on guarded tests performed at the site) -- calculated a space conditioning energy cost savings of 15% to 21% due to the air sealing retrofit. Important air leakage locations identified included plumbing and electrical penetrations, dropped ceilings/soffits, windows, ducts and wall-to-floor intersections. Previous repair activity had created significant leakage locations as well. Specifications and a pictorial guide were developed for contractors performing the work.

  8. A Novel Approach for Modeling and Simulation of Helix Twisting Structure Based on Mass-Spring Model

    Directory of Open Access Journals (Sweden)

    Zhongbin Wang

    2013-01-01

    Full Text Available In order to improve the modeling efficiency and realize the deformation simulation of helix twisting structure, a computer-aided design system based on mass-spring model is developed. The geometry structure of helix twisting structure is presented and mass-spring model is applied in the deformation simulation. Moreover, the key technologies such as coordinate mapping, system render and system architecture are elaborated. Finally, a prototype system is developed with Visual C++ and OpenGL, and the proposed system is proved efficient through a comparison experiment.

  9. Modeling data irregularities and structural complexities in data envelopment analysis

    CERN Document Server

    Zhu, Joe

    2007-01-01

    In a relatively short period of time, Data Envelopment Analysis (DEA) has grown into a powerful quantitative, analytical tool for measuring and evaluating performance. It has been successfully applied to a whole variety of problems in many different contexts worldwide. This book deals with the micro aspects of handling and modeling data issues in modeling DEA problems. DEA's use has grown with its capability of dealing with complex "service industry" and the "public service domain" types of problems that require modeling of both qualitative and quantitative data. This handbook treatment deals with specific data problems including: imprecise or inaccurate data; missing data; qualitative data; outliers; undesirable outputs; quality data; statistical analysis; software and other data aspects of modeling complex DEA problems. In addition, the book will demonstrate how to visualize DEA results when the data is more than 3-dimensional, and how to identify efficiency units quickly and accurately.

  10. Structure defect prediction of single crystal turbine blade by dendrite envelope tracking model

    Institute of Scientific and Technical Information of China (English)

    WANG Tong-min; Itsuo OHNAKA; Hideyuki YASUDA; SU Yan-qing; GUO Jing-jie

    2006-01-01

    The structure defects such as stray grains during unidirectional solidification can severely reduce the performance of single crystal turbine blades. A dendrite envelope tracking model is developed for predicting the structure defects of unidirectional solidification turbine blade. The normal vector of dendrite envelope is estimated by the gradient of dendrite volume fraction,and the growth velocity of the dendrite envelope (dendrite tips) is calculated with considering the anisotropy of grain growth. The solute redistribution at dendrite envelope is calculated by introducing an effective solute partition coefficient. Simulation tests show that the solute-build-up due to the rejection at envelope greatly affects grain competition and consequently solidification structure. The model is applied to predict the structure defects (e.g. stray grain) of single crystal turbine blade during unidirectional solidification. The results show that the developed model is reliable and has the following abilities: reproduce the growth competition among the different-preferential-direction grains:predict the stray grain formation:simulate the structure evolution (single crystal or dendrite grains).

  11. Colloidal membranes of hard rods: unified theory of free edge structure and twist walls.

    Science.gov (United States)

    Kaplan, C Nadir; Meyer, Robert B

    2014-07-14

    Monodisperse suspensions of rod like chiral fd viruses are condensed into a rod-length thick colloidal monolayers of aligned rods by depletion forces. Twist deformations of the molecules are expelled to the monolayer edge as in a chiral smectic A liquid crystal, and a cholesteric band forms at the edge. Coalescence of two such isolated membranes results in a twist wall sandwiched between two regions of aligned rods, dubbed π-walls. By modeling the membrane as a binary fluid of coexisting cholesteric and chiral smectic A liquid-crystalline regions, we develop a unified theory of the π-walls and the monolayer edge. The mean-field analysis of our model yields the molecular tilt profiles, the local thickness change, and the crossover from smectic to cholesteric behavior at the monolayer edge and across the π-wall. Furthermore, we calculate the line tension associated with the formation of these interfaces. Our model offers insights regarding the stability and the detailed structure of the π-wall and the monolayer edge.

  12. Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist.

    Science.gov (United States)

    Törnroth-Horsefield, Susanna; Gourdon, Pontus; Horsefield, Rob; Brive, Lars; Yamamoto, Natsuko; Mori, Hirotada; Snijder, Arjan; Neutze, Richard

    2007-12-01

    Bacterial drug resistance is a serious concern for human health. Multidrug efflux pumps export a broad variety of substrates out of the cell and thereby convey resistance to the host. In Escherichia coli, the AcrB:AcrA:TolC efflux complex forms a principal transporter for which structures of the individual component proteins have been determined in isolation. Here, we present the X-ray structure of AcrB in complex with a single transmembrane protein, assigned by mass spectrometry as YajC. A specific rotation of the periplasmic porter domain of AcrB is also revealed, consistent with the hypothesized "twist-to-open" mechanism for TolC activation. Growth experiments with yajc-deleted E. coli reveal a modest increase in the organism's susceptibility to beta-lactam antibiotics, but this effect could not conclusively be attributed to the loss of interactions between YajC and AcrB.

  13. Alternating twist structures formed by electroconvection in the nematic phase of an achiral bent-core molecule.

    Science.gov (United States)

    Tanaka, Shingo; Dhara, Surajit; Sadashiva, B K; Shimbo, Yoshio; Takanishi, Yoichi; Araoka, Fumito; Ishikawa, Ken; Takezoe, Hideo

    2008-04-01

    We report an unusual electroconvection in the nematic phase of a bent-core liquid crystal. In a voltage-frequency diagram, two frequency regions exhibiting prewavy stripe patterns were found, as reported by Wiant We found that these stripes never show extinction dark when cells were rotated under crossed polarizers. Based on the color interchange in between neighboring stripes by the rotation of the cells or an analyzer, twisted molecular orientation is suggested; i.e., the directors are alternately twisted from the top to the bottom surfaces with a pretilt angle in adjacent stripes, which is an analogue of the twisted (splayed) structure observed in surface-stabilized ferroelectric liquid crystal cells. The transmittance spectra calculated using the 4x4 matrix method from the model structure are consistent with the experimental observation.

  14. Periodic Structure of Equatorial Envelope Rossby Wave Under Influence of Diabatic Heating

    Institute of Scientific and Technical Information of China (English)

    FUZun-Tao; CHENZhe; LIUShi-Da; LIUShi-Kuo

    2004-01-01

    A simple shallow-water model with influence of diabatic heating on a β-plane is applied to investigate the nonlinear equatorial Rossby waves in a shear flow. By the asymptotic method of multiple scales, the cubic nonlinear Schroedinger (NLS for short) equation with an external heating source is derived for large amplitude equatorial envelope Rossby wave in a shear flow. And then various periodic structures for these equatorial envelope Rossby waves are obtained with the help of Jacob/elliptic functions and elliptic equation. It is shown that phase-locked diabatic heating plays an important role in periodic structures of rational form.

  15. Periodic Structure of Equatorial Envelope Rossby Wave Under Influence of Diabatic Heating

    Institute of Scientific and Technical Information of China (English)

    FU Zun-Tao; CHEN Zhe; LIU Shi-Da; LIU Shi-Kuo

    2004-01-01

    A simple shallow-water model with influence of diabatic heating on aβ-plane is applied to investigate the nonlinear equatorial Rossby waves in a shear flow. By the asymptotic method of multiple scales, the cubic nonlinear Schrodinger (NLS for short) equation with an external heating source is derived for large amplitude equatorial envelope Rossby wave in a shear flow. And then various periodic structures for these equatorial envelope Rossby waves are obtained with the help of Jacobi elliptic functions and elliptic equation. It is shown that phase-locked diabatic heating plays an important role in periodic structures of rational form.

  16. Higher twist contributions to the structure functions F{sub 2}(x, Q{sup 2}) and g{sub 2}(x, Q{sup 2})

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes; Boettcher, Helmut

    2012-07-15

    We report on recent results on higher twist contributions to the unpolarized structure functions F{sup p,d}{sub 2}(x,Q{sup 2}) at N{sup 3}LO in the large x region and constraints on the twist-3 contribution to polarized structure function g{sub 2}(x,Q{sup 2}).

  17. The Velocity Structure of SN 1987A's Outer Circumstellar Envelope

    Science.gov (United States)

    Crotts, A. P. S.; Heathcote, S. R.

    1997-12-01

    We present high-resolution optical spectroscopy, (obtained with the CTIO 4-meter/echelle spectrograph over many epochs between 1989 and 1997) of the circumstellar nebula of SN 1987A, including the outer rings (within 3 arcsec of the SN), the inner (equatorial) ring, and fainter features at larger radii never studied before spectroscopically. We report velocity displacements for portions of the outer rings, up to 26 km s(-1) with respect the SN centroid velocity, with blueshifted components in the location of the southern outer ring and the redshifted portions of the northern outer ring. The largest shifts are near the SN, as predicted by a model in which the outer rings are the crowns of an expanding, bipolar nebula with the inner ring at its waist. We also confirm that the inner ring shows a velocity full-width of about 13 km s(-1) , which, along with the geometry of the rings and our outer ring velocity measurements, allows us to estimate a characteristic timescale of about 20,000 y for each of the three rings, implying that all are coeval. This contrasts with measurements by others of compositional ratios in the inner versus outer rings indicating that they were, perhaps, ejected at different times from the progenitor's star's outer envelope. Additionally, we measure the velocity of low surface brightness features at larger radii indicating that circumstellar material even farther from the SN was ejected up to 400,000 y before the explosion. Finally, we note the presence of transient emission features within the circumstellar nebula and describe their behaviour, and consider what implications our observations may have for the coming transformation of this nebula into Supernova Remnant 1987A.

  18. Higher-Twist Contribution to Pion Structure Function 4-Fermi Operators

    CERN Document Server

    Capitani, S; Horsley, R; Klaus, B; Linke, V; Rakow, P E L; Schäfer, A; Schierholz, G

    2000-01-01

    We present quenched lattice QCD results for the contribution of higher-twist operators to the lowest non-trivial moment of the pion structure function. To be specific, we consider the combination $F_2^{\\pi^+} + F_2^{\\pi^-} - 2 F_2^{\\pi^0}$ which has $I = 2$ and receives contributions from 4-Fermi operators only. We introduce the basis of lattice operators. The renormalization of the operators is done perturbatively in the $\\bar{\\rm{MS}}$ scheme using the 't Hooft-Veltman prescription for $\\gamma_5$, taking particular care of mixing effects. The contribution is found to be of $O(f_\\pi^2/Q^2)$, relative to the leading contribution to the moment of $F_2^{\\pi^+}$.

  19. Twist-2 Generalized TMDs and the Spin/Orbital Structure of the Nucleon

    CERN Document Server

    Kanazawa, K; Metz, A; Pasquini, B; Schlegel, M

    2014-01-01

    Generalized transverse-momentum dependent parton distributions (GTMDs) encode the most general parton structure of hadrons. Here we focus on two twist-2 GTMDs which are denoted by $F_{1,4}$ and $G_{1,1}$ in parts of the literature. As already shown previously, both GTMDs have a close relation to orbital angular momentum of partons inside a hadron. However, recently even the mere existence of $F_{1,4}$ and $G_{1,1}$ has been doubted. We explain why this claim does not hold. We support our model-independent considerations by calculating the two GTMDs in the scalar diquark model and in the quark-target model, where we also explicitly check the relation to orbital angular momentum. In addition, we compute $F_{1,4}$ and $G_{1,1}$ at large transverse momentum in perturbative Quantum Chromodynamics and show that they are nonzero.

  20. Differential Hopf algebra structures on the universal enveloping algebra ofa Lie algebra

    NARCIS (Netherlands)

    Hijligenberg, N.W. van den; Martini, R.

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra structure of $U(g

  1. Differential Hopf algebra structures on the universal enveloping algebra of a Lie algebra

    NARCIS (Netherlands)

    van den Hijligenberg, N.W.; van den Hijligenberg, N.W.; Martini, Ruud

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra structure of

  2. Testing an inference of function from structure: snake vertebrae do the twist.

    Science.gov (United States)

    Moon, B R

    1999-09-01

    The zygapophyses and zygosphene-zygantrum articulations of snake vertebrae are hypothesized to restrict or eliminate vertebral torsion. This hypothesis is apparently based solely on the inference of function from structure, despite the limitations of such inferences, as well as contradictory observations and measurements. In this study, I observed and measured axial torsion in gopher snakes, Pituophis melanoleucus. To examine the structural basis of axial torsion, I measured the vertebral articulation angles along the body and the insertion angles of five epaxial muscles. To examine torsion in a natural behavior, I digitized video images and measured the degree of apparent axial torsion during terrestrial lateral undulation. Finally, I measured the mechanical capacity of the vertebral joints for actual torsion over intervals of 10 vertebrae in fresh, skinned segments of the trunk. Vertebral articulation angles vary up to 30 degrees and are associated with variation in torsional capacity along the trunk. The freely crawling P. melanoleucus twisted up to 2.19 degrees per vertebra, which produced substantial overall torsion when added over several vertebrae. The vertebral joints are mechanically capable of torsion up to 2.89 degrees per joint. Therefore, despite the mechanical restriction imposed by the complex articulations, vertebral torsion occurs in snakes and appears to be functionally important in several natural behaviors. Even in cases in which mechanical function appears to be narrowly constrained by morphology, specific functions should not be inferred solely from structural analyses. Copyright 1999 Wiley-Liss, Inc.

  3. Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining

    Energy Technology Data Exchange (ETDEWEB)

    Andres,S.; Modesit, M.; Tsai, C.; Chu, G.; Junop, M.

    2007-01-01

    DNA double-strand breaks represent one of the most severe forms of DNA damage in mammalian cells. One pathway for repairing these breaks occurs via nonhomologous end-joining (NHEJ) and depends on XRCC4, LigaseIV, and Cernunnos, also called XLF. Although XLF stimulates XRCC4/LigaseIV to ligate mismatched and noncohesive DNA ends, the mechanistic basis for this function remains unclear. Here we report the structure of a partially functional 224 residue N-terminal fragment of human XLF. Despite only weak sequence similarity, XLF1-170 shares structural homology with XRCC41-159. However, unlike the highly extended 130 Angstroms helical domain observed in XRCC4, XLF adopts a more compact, folded helical C-terminal region involving two turns and a twist, wrapping back to the structurally conserved N terminus. Mutational analysis of XLF and XRCC4 reveals a potential interaction interface, suggesting a mechanism for how XLF stimulates the ligation of mismatched ends.

  4. Differential Hopf algebra structures on the universal enveloping algebra of a lie algebra

    OpenAIRE

    Hijligenberg, van den, N.W.; Martini, R.

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra structure of $U(g)$. The construction of such differential structures is interpreted in terms of colour Lie superalgebras.

  5. One-dimensional structures behind twisted and untwisted super Yang-Mills theory

    Energy Technology Data Exchange (ETDEWEB)

    Baulieu, Laurent [CERN, Geneve (Switzerland). Theoretical Div.; Toppan, Francesco, E-mail: baulieu@lpthe.jussieu.f, E-mail: toppan@cbpf.b [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)

    2010-07-01

    We give a one-dimensional interpretation of the four-dimensional twisted N = 1 super Yang-Mills theory on a Kaehler manifold by performing an appropriate dimensional reduction. We prove the existence of a 6-generator superalgebra, which does not possess any invariant Lagrangian but contains two different subalgebras that determine the twisted and untwisted formulations of the N = 1 super Yang-Mills theory. (author)

  6. One-dimensional structures behind twisted and untwisted superYang-Mills theory

    CERN Document Server

    Baulieu, Laurent

    2011-01-01

    We give a one-dimensional interpretation of the four-dimensional twisted N=1 superYang-Mills theory on a Kaehler manifold by performing an appropriate dimensional reduction. We prove the existence of a 6-generator superalgebra, which does not possess any invariant Lagrangian but contains two different subalgebras that determine the twisted and untwisted formulations of the N=1 superYang-Mills theory.

  7. Impact of electromagnetism on phase structure for Wilson and twisted-mass fermions including isospin breaking

    CERN Document Server

    Horkel, Derek P

    2015-01-01

    In a recent paper we used chiral perturbation theory to determine the phase diagram and pion spectrum for Wilson and twisted-mass fermions at non-zero lattice spacing with non-degenerate up and down quarks. Here we extend this work to include the effects of electromagnetism, so that it is applicable to recent simulations incorporating all sources of isospin breaking. For Wilson fermions, we find that the phase diagram is unaffected by the inclusion of electromagnetism---the only effect is to raise the charged pion masses. For maximally twisted fermions, we previously took the twist and isospin-breaking directions to be different, in order that the fermion determinant is real and positive. However, this is incompatible with electromagnetic gauge invariance, and so here we take the twist to be in the isospin-breaking direction, following the RM123 collaboration. We map out the phase diagram in this case, which has not previously been studied. The results differ from those obtained with different twist and isosp...

  8. Twisted equivariant matter

    CERN Document Server

    Freed, Daniel S

    2012-01-01

    We show how general principles of symmetry in quantum mechanics lead to twisted notions of a group representation. This framework generalizes both the classical 3-fold way of real/complex/quaternionic representations as well as a corresponding 10-fold way which has appeared in condensed matter and nuclear physics. We establish a foundation for discussing continuous families of quantum systems. Having done so, topological phases of quantum systems can be defined as deformation classes of continuous families of gapped Hamiltonians. For free particles there is an additional algebraic structure on the deformation classes leading naturally to notions of twisted equivariant K-theory. In systems with a lattice of translational symmetries we show that there is a canonical twisting of the equivariant K-theory of the Brillouin torus. We give precise mathematical definitions of two invariants of the topological phases which have played an important role in the study of topological insulators. Twisted equivariant K-theor...

  9. Poly(meta-phenylene) Derivative with Rigid Twisted Biphenyl Units in Backbone: Synthesis, Structural Characterization,Photophysical Properties and Electroluminescence

    Institute of Scientific and Technical Information of China (English)

    ZHENG Yan; YANG Bing; ZHANG Hai-quan; LU Ping; SHEN Fang-zhong; LIU Lin-lin; XU Hai; YANG Guang-di; MA Yu-guang

    2007-01-01

    A soluble poly(meta-phenylene) derivative with rigid twisted biphenyl unit was synthesized by the Yamamoto coupling reaction. The polymer is soluble in common organic solvents, and the number-average molecular weight is about 6500. The UV-Vis and quantum chemical calculation indicate that the different conformation segments named "conformers" exist in the polymer backbones; it was also further confirmed by the single crystal X-ray diffraction study of the dimeric model compound. The π-π* transition of biphenyl segments of twisted and planar conformations made the polymer exhibit a strong absorption around 256 nm and a weak absorption at about 300 nm. Furthermore,the polymer exhibits a strong UV photoluminescence at 372 nm when the excitation wavelengths are longer than 300 nm. The ultraviolet-emitting electroluminescence(EL) device with the single layer structure shows EL λmax of the derivative at 370 nm.

  10. Travelling and standing envelope solitons in discrete non-linear cyclic structures

    Science.gov (United States)

    Grolet, Aurelien; Hoffmann, Norbert; Thouverez, Fabrice; Schwingshackl, Christoph

    2016-12-01

    Envelope solitons are demonstrated to exist in non-linear discrete structures with cyclic symmetry. The analysis is based on the Non-Linear Schrodinger Equation for the weakly non-linear limit, and on numerical simulation of the fully non-linear equations for larger amplitudes. Envelope solitons exist for parameters in which the wave equation is focussing and they have the form of shape-conserving wave packages propagating roughly with group velocity. For the limit of maximum wave number, where the group velocity vanishes, standing wave packages result and can be linked via a bifurcation to the non-localised non-linear normal modes. Numerical applications are carried out on a simple discrete system with cyclic symmetry which can be seen as a reduced model of a bladed disk as found in turbo-machinery.

  11. Aeroelastic analysis for helicopter rotor blades with time-variable, non-linear structural twist and multiple structural redundancy: Mathematical derivation and program user's manual

    Science.gov (United States)

    Bielawa, R. L.

    1976-01-01

    The differential equations of motion for the lateral and torsional deformations of a nonlinearly twisted rotor blade in steady flight conditions together with those additional aeroelastic features germane to composite bearingless rotors are derived. The differential equations are formulated in terms of uncoupled (zero pitch and twist) vibratory modes with exact coupling effects due to finite, time variable blade pitch and, to second order, twist. Also presented are derivations of the fully coupled inertia and aerodynamic load distributions, automatic pitch change coupling effects, structural redundancy characteristics of the composite bearingless rotor flexbeam - torque tube system in bending and torsion, and a description of the linearized equations appropriate for eigensolution analyses. Three appendixes are included presenting material appropriate to the digital computer program implementation of the analysis, program G400.

  12. Structural models of the membrane anchors of envelope glycoproteins E1 and E2 from pestiviruses

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jimin, E-mail: jimin.wang@yale.edu; Li, Yue; Modis, Yorgo, E-mail: yorgo.modis@yale.edu

    2014-04-15

    The membrane anchors of viral envelope proteins play essential roles in cell entry. Recent crystal structures of the ectodomain of envelope protein E2 from a pestivirus suggest that E2 belongs to a novel structural class of membrane fusion machinery. Based on geometric constraints from the E2 structures, we generated atomic models of the E1 and E2 membrane anchors using computational approaches. The E1 anchor contains two amphipathic perimembrane helices and one transmembrane helix; the E2 anchor contains a short helical hairpin stabilized in the membrane by an arginine residue, similar to flaviviruses. A pair of histidine residues in the E2 ectodomain may participate in pH sensing. The proposed atomic models point to Cys987 in E2 as the site of disulfide bond linkage with E1 to form E1–E2 heterodimers. The membrane anchor models provide structural constraints for the disulfide bonding pattern and overall backbone conformation of the E1 ectodomain. - Highlights: • Structures of pestivirus E2 proteins impose constraints on E1, E2 membrane anchors. • Atomic models of the E1 and E2 membrane anchors were generated in silico. • A “snorkeling” arginine completes the short helical hairpin in the E2 membrane anchor. • Roles in pH sensing and E1–E2 disulfide bond formation are proposed for E1 residues. • Implications for E1 ectodomain structure and disulfide bonding pattern are discussed.

  13. An equilibrium double-twist model for the radial structure of collagen fibrils

    CERN Document Server

    Brown, Aidan I; Rutenberg, Andrew D

    2014-01-01

    Mammalian tissues contain networks and ordered arrays of collagen fibrils originating from the periodic self-assembly of helical 300 nm long tropocollagen complexes. The fibril radius is typically between 25 to 250 nm, and tropocollagen at the surface appears to exhibit a characteristic twist-angle with respect to the fibril axis. Similar fibril radii and twist-angles at the surface are observed in vitro, suggesting that these features are controlled by a similar self-assembly process. In this work, we propose a physical mechanism of equilibrium radius control for collagen fibrils based on a radially varying double-twist alignment of tropocollagen within a collagen fibril. The free-energy of alignment is similar to that of liquid crystalline blue phases, and we employ an analytic Euler-Lagrange and numerical free energy minimization to determine the twist-angle between the molecular axis and the fibril axis along the radial direction. Competition between the different elastic energy components, together with ...

  14. Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry

    Directory of Open Access Journals (Sweden)

    Kamel El Omari

    2013-01-01

    Full Text Available Enveloped viruses have developed various adroit mechanisms to invade their host cells. This process requires one or more viral envelope glycoprotein to achieve cell attachment and membrane fusion. Members of the Flaviviridae such as flaviviruses possess only one envelope glycoprotein, E, whereas pestiviruses and hepacivirus encode two glycoproteins, E1 and E2. Although E2 is involved in cell attachment, it has been unclear which protein is responsible for membrane fusion. We report the crystal structures of the homodimeric glycoprotein E2 from the pestivirus bovine viral diarrhea virus 1 (BVDV1 at both neutral and low pH. Unexpectedly, BVDV1 E2 does not have a class II fusion protein fold, and at low pH the N-terminal domain is disordered, similarly to the intermediate postfusion state of E2 from sindbis virus, an alphavirus. Our results suggest that the pestivirus and possibly the hepacivirus fusion machinery are unlike any previously observed.

  15. CHARACTERIZING THE YOUNGEST HERSCHEL-DETECTED PROTOSTARS. I. ENVELOPE STRUCTURE REVEALED BY CARMA DUST CONTINUUM OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, John J. [National Radio Astronomy Observatory, Charlottesville, VA 22903 (United States); Stutz, Amelia M.; Henning, Thomas; Ragan, Sarah E. [Max-Planck-Institut für Astronomie, D-69117 Heidelberg (Germany); Megeath, S. Thomas; Fischer, William J. [Ritter Astrophysical Observatory, Department of Physics and Astronomy, University of Toledo, Toledo, OH 43560 (United States); Ali, Babar [NASAHerschel Science Center, California Institute of Technology, Pasadena, CA 91125 (United States); Stanke, Thomas [European Southern Observatory, D-85748 Garching bei München (Germany); Manoj, P. [Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, Colaba, Mumbai 400005 (India); Calvet, Nuria; Hartmann, Lee, E-mail: tobin@strw.leidenuniv.nl [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States)

    2015-01-10

    We present Combined Array for Research in Millimeter-wave Astronomy 2.9 mm dust continuum emission observations of a sample of 14 Herschel-detected Class 0 protostars in the Orion A and B molecular clouds, drawn from the PACS Bright Red Sources (PBRS) sample. These objects are characterized by very red 24-70 μm colors and prominent submillimeter emission, suggesting that they are very young Class 0 protostars embedded in dense envelopes. We detect all of the PBRS in 2.9 mm continuum emission and emission from four protostars and one starless core in the fields toward the PBRS; we also report one new PBRS source. The ratio of 2.9 mm luminosity to bolometric luminosity is higher by a factor of ∼5 on average, compared to other well-studied protostars in the Perseus and Ophiuchus clouds. The 2.9 mm visibility amplitudes for 6 of the 14 PBRS are very flat as a function of uv distance, with more than 50% of the source emission arising from radii <1500 AU. These flat visibility amplitudes are most consistent with spherically symmetric envelope density profiles with ρ ∝ R {sup –2.5}. Alternatively, there could be a massive unresolved structure like a disk or a high-density inner envelope departing from a smooth power law. The large amount of mass on scales <1500 AU (implying high average central densities) leads us to suggest that that the PBRS with flat visibility amplitude profiles are the youngest PBRS and may be undergoing a brief phase of high mass infall/accretion and are possibly among the youngest Class 0 protostars. The PBRS with more rapidly declining visibility amplitudes still have large envelope masses, but could be slightly more evolved.

  16. The chemical structure of the Class 0 protostellar envelope NGC 1333 IRAS 4A⋆⋆

    Science.gov (United States)

    Koumpia, E.; Semenov, D. A.; van der Tak, F. F. S.; Boogert, A. C. A.; Caux, E.

    2017-07-01

    Context. It is not well known what drives the chemistry of a protostellar envelope, in particular the role of the stellar mass and the protostellar outflows on the chemical enrichment of such environments. Aims: We study the chemical structure of the Class 0 protostellar envelope NGC 1333 IRAS 4A in order to (i) investigate the influence of the outflows on the chemistry; (ii) constrain the age of our studied object; (iii) compare it with a typical high-mass protostellar envelope. Methods: In our analysis we use JCMT line mapping (360-373 GHz) and HIFI pointed spectra (626.01-721.48 GHz). To study the influence of the outflow on the degree of deuteration, we compare JCMT maps of HCO+ and DCO+ with non-LTE (RADEX) models in a region that spatially covers the outflow activity of IRAS 4A. To study the envelope chemistry, we derive empirical molecular abundance profiles for the observed species using the Monte Carlo radiative transfer code (RATRAN) and adopting a 1D dust density/temperature profile from the literature. We use a combination of constant abundance profiles and abundance profiles that include jumps at two radii (T 100 K or T 30 K) to fit our observations. We compare our best-fit observed abundance profiles with the predictions from the time dependent gas grain chemical code (ALCHEMIC). Results: We detect CO, 13CO, C18O, CS, HCN, HCO+, N2H+, H2CO, CH3OH, H2O, H2S, DCO+, HDCO, D2CO, SO, SO2, SiO, HNC, CN, C2H and OCS. We divide the detected lines in three groups based on their line profiles: a) broad emission (FWHM = 4-11 km s-1), b) narrow emission (FWHMmodel for the outer envelope, with the exceptions of HCN, HNC, CN. These species along with the CO abundance require an enhanced UV field which points towards an outflow cavity. The abundances with respect to H2 are 1 to 2 orders of magnitude lower than those observed in the high mass protostellar envelope (AFGL 2591), while they are found to be similar within factors of a few when they are estimated with

  17. Structural proteins of ribonucleic acid tumor viruses. Purification of envelope, core, and internal components.

    Science.gov (United States)

    Strand, M; August, J T

    1976-01-25

    Murine type C virus structural proteins, the envelope glycopeptides, 30,000 dalton major core protein, and 15,000 dalton internal protein have each been purified to near homogeneity and in high yield from the smae batch of virus by use of phosphocellulose column chromatography and gel filtration procedures. Evidence that these proteins are specified by the viral genome was obtained by competition radioimmunoassay analysis, comparing these polypeptides from Rauscher virus cultivated in a variety of mammalian cell lines; all of the reactive antigenic determinants of these proteins appeared to be virus-specific.

  18. The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation

    Energy Technology Data Exchange (ETDEWEB)

    Li, Long; Lok, Shee-Mei; Yu, I-Mei; Zhang, Ying; Kuhn, Richard J.; Chen, Jue; Rossmann, Michael G. (Purdue)

    2008-09-17

    Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom resolution crystal structure of a recombinant protein in which the dengue virus prM is linked to the envelope glycoprotein E. The structure represents the prM-E heterodimer and fits well into the cryo-electron microscopy density of immature virus at neutral pH. The pr peptide {beta}-barrel structure covers the fusion loop in E, preventing fusion with host cell membranes. The structure provides a basis for identifying the stages of its pH-directed conformational metamorphosis during maturation, ending with release of pr when budding from the host.

  19. ELECTROOPTICAL CHARACTERISTICS OF SPACE-INTEGRATED MODULATING STRUCTURES ON TWIST EFFECT IN LIQUID CRYSTALS

    Directory of Open Access Journals (Sweden)

    Yu. V. Razvin

    2014-01-01

    Full Text Available The paper demonstrates that the process of twist LC-pixel switching can be associated not only with a reorientation of liquid crystal molecules in the controlling electric field, but also with the effect of compression of the LC-spiral to the central area through layer thickness. In this case the time of LC-pixel total switching is decreased by almost three orders.

  20. ELECTROOPTICAL CHARACTERISTICS OF SPACE-INTEGRATED MODULATING STRUCTURES ON TWIST EFFECT IN LIQUID CRYSTALS

    OpenAIRE

    Yu. V. Razvin; V. A. Potachits

    2014-01-01

    The paper demonstrates that the process of twist LC-pixel switching can be associated not only with a reorientation of liquid crystal molecules in the controlling electric field, but also with the effect of compression of the LC-spiral to the central area through layer thickness. In this case the time of LC-pixel total switching is decreased by almost three orders.

  1. Determining the Structure of an Unliganded and Fully Glycosylated SIV gp120 Envelope Glycoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Bing; Vogan, Erik M.; Gong, Haiyun; Skehel, John J.; Wiley, Don C.; Harrison, Stephen C. (Harvard-Med); (NIMR)

    2010-07-13

    HIV/SIV envelope glycoproteins mediate the first steps in viral infection. They are trimers of a membrane-anchored polypeptide chain, cleaved into two fragments known as gp120 and gp41. The structure of HIV gp120 bound with receptor (CD4) has been known for some time. We have now determined the structure of a fully glycosylated SIV gp120 envelope glycoprotein in an unliganded conformation by X-ray crystallography at 4.0 {angstrom} resolution. We describe here our experimental and computational approaches, which may be relevant to other resolution-limited crystallographic problems. Key issues were attention to details of beam geometry mandated by small, weakly diffracting crystals, and choice of strategies for phase improvement, starting with two isomorphous derivatives and including multicrystal averaging. We validated the structure by analyzing composite omit maps, averaged among three distinct crystal lattices, and by calculating model-based, SeMet anomalous difference maps. There are at least four ordered sugars on many of the thirteen oligosaccharides.

  2. Wigner oscillators, twisted Hopf algebras and second quantization

    Energy Technology Data Exchange (ETDEWEB)

    Castro, P.G.; Toppan, F. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)]. E-mails: pgcastro@cbpf.br; toppan@cbpf.br; Chakraborty, B. [S. N. Bose National Center for Basic Sciences, Kolkata (India)]. E-mail: biswajit@bose.res.in

    2008-07-01

    By correctly identifying the role of central extension in the centrally extended Heisenberg algebra h, we show that it is indeed possible to construct a Hopf algebraic structure on the corresponding enveloping algebra U(h) and eventually deform it through Drinfeld twist. This Hopf algebraic structure and its deformed version U{sup F}(h) is shown to be induced from a more 'fundamental' Hopf algebra obtained from the Schroedinger field/oscillator algebra and its deformed version, provided that the fields/oscillators are regarded as odd-elements of a given superalgebra. We also discuss the possible implications in the context of quantum statistics. (author)

  3. Structures in material transference and vitelline envelope formation in Betta splendens follicles.

    Science.gov (United States)

    Genta, H D

    1996-01-01

    Structures were found by transmission electron microscopy, they were located within follicular cells and the oocyte, and in the interspace between them in follicles of the teleost fish Betta splendens. Some structures with features characteristic or lamellar bodies were found in small follicles. The possible role of these structures in the formation of the vitelline envelope as well as in the material transference is discussed. Vacuoles, vesticles and particles intensely stained were found in the microvilli and the cortical cytoplasm of the oocyte at the onset of vitellogenesis. These results suggest that different substances present in the cellular components of the follicle might be transferred from cell to cell through the extracellular space and through the prolongations that cross the extracellular space.

  4. Lipid quantification and structure determination of nuclear envelope precursor membranes in the sea urchin.

    Science.gov (United States)

    Garnier-Lhomme, Marie; Dufourc, Erick J; Larijani, Banafshé; Poccia, Dominic

    2009-01-01

    Nuclear envelope assembly is a fundamental cellular process normally taking place once in every cell cycle in eukaryotes. The timing of fusion of nuclear membrane precursors to form the complete double membrane surrounding the chromosomes is tightly controlled, but much remains unclear concerning its regulation. Small amounts of material available and the high background of irrelevant cellular membranes have limited detailed analysis. We have employed several sensitive and high-resolution techniques to analyze the nuclear membrane structure, composition, and dynamics using purified membrane fractions and a cell-free system that results in nuclear envelope formation. We discuss the application of cholesterol and phospholipid colorimetric assays, fluorescent filipin labeling, electrospray ionization tandem mass spectrometry coupled to HPLC (HPLC-ESI/MS/MS), electron microscopy (EM), and solid-state nuclear magnetic resonance (NMR) spectroscopy. Colorimetric assays determine the amounts of inorganic phosphates from phospholipids and cholesterol/ cholesteryl esters present in membrane-containing fractions. Filipin staining of natural membranes allows the localization and relative quantification of cholesterol. HPLC-ESI/MS/MS determines the quantitative composition of membrane phospholipid species from small amounts of membranes. Cryosectioning of cryoprotected sperm cells facilitates EM verification of membrane domains existing in vivo. Deuterium solid-state NMR provides information about membrane rigidity and lipid-phase behavior. The sensitivity, quantification, and structural determinations provided by these techniques should prove useful in studying membrane dynamics in a variety of systems exhibiting membrane fusion.

  5. Twisting Somersault

    CERN Document Server

    Dullin, Holger R

    2015-01-01

    A complete description of twisting somersaults is given using a reduction to a time-dependent Euler equation for non-rigid body dynamics. The central idea is that after reduction the twisting motion is apparent in a body frame, while the somersaulting (rotation about the fixed angular momentum vector in space) is recovered by a combination of dynamic and geometric phase. In the simplest "kick-model" the number of somersaults $m$ and the number of twists $n$ are obtained through a rational rotation number $W = m/n$ of a (rigid) Euler top. This rotation number is obtained by a slight modification of Montgomery's formula [9] for how much the rigid body has rotated. Using the full model with shape changes that take a realistic time we then derive the master twisting-somersault formula: An exact formula that relates the airborne time of the diver, the time spent in various stages of the dive, the numbers $m$ and $n$, the energy in the stages, and the angular momentum by extending a geometric phase formula due to C...

  6. Oliver Twist

    NARCIS (Netherlands)

    Dickens, Charles

    2005-01-01

    Oliver Twist is one of Dickens's most popular novels, with many famous film, television and musical adaptations. It is a classic story of good against evil, packed with humour and pathos, drama and suspense, in which the orphaned Oliver is brought up in a harsh workhouse, and then taken in and

  7. Oliver Twist

    NARCIS (Netherlands)

    Dickens, Charles

    2005-01-01

    Oliver Twist is one of Dickens's most popular novels, with many famous film, television and musical adaptations. It is a classic story of good against evil, packed with humour and pathos, drama and suspense, in which the orphaned Oliver is brought up in a harsh workhouse, and then taken in and explo

  8. Processing, Structural Characterization and Comparative Studies on Uniaxial Tensile Properties of a New Type of Porous Twisted Wire Material

    Directory of Open Access Journals (Sweden)

    Fei Wu

    2015-08-01

    Full Text Available A self-developed rotary multi-cutter device cuts stainless steel wire ropes into segments to fabricate twisted wires. Stainless steel porous twisted wire materials (PTWMs with a spatial composite intertexture structure are produced by the compaction and subsequent vacuum solid-phase sintering of twisted wires. The stainless steel PTWMs show two types of typical uniaxial tensile failure modes, i.e., a 45° angle fracture mode and an auxetic failure mode (the PTWMs expand along the direction perpendicular to the tension. The effects of the sintering parameters, porosities, wire diameters, and sampling direction on the tensile properties of the PTWMs are carefully investigated. By increasing the sintering temperature from 1130 °C to 1330 °C, the tensile strength of the PTWMs with 70% target porosity increased from 7.7 MPa to 28.6 MPa and the total failure goes down to 50%. When increasing the sintering time from 90 min to 150 min, the tensile strength increases from 12.4 MPa to 19.1 MPa and the total failure elongation drops to 78.6%. The tensile strength of the PTWMs increases from 28.9 MPa to 112.7 MPa with decreasing porosity from 69.5% to 46.0%, and the total failure elongation also increases from 14.8% to 40.7%. The tensile strength and the failure strain of the PTWMs with fine wires are higher than those of the PTWMs with coarse wires under the same porosity. Sampling direction has a small influence on the tensile properties of the PTWMs.

  9. Drinfel'd basis of twisted Yangians

    CERN Document Server

    Belliard, Samuel

    2014-01-01

    We present a quantization of a Lie bi-ideal structure for twisted half-loop algebras of finite dimensional simple complex Lie algebras. We obtain Drinfel'd basis formalism and algebra closure relations of twisted Yangians for all symmetric pairs of simple Lie algebras and for simple twisted even half-loop Lie algebras. We also give an explicit form of twisted Yangians in Drinfel'd basis for the sl3 Lie algebra.

  10. Structure and deformations of strongly magnetized neutron stars with twisted torus configurations

    CERN Document Server

    Ciolfi, R; Gualtieri, L

    2010-01-01

    We construct general relativistic models of stationary, strongly magnetized neutron stars. The magnetic field configuration, obtained by solving the relativistic Grad-Shafranov equation, is a generalization of the twisted torus model recently proposed in the literature; the stellar deformations induced by the magnetic field are computed by solving the perturbed Einstein's equations; stellar matter is modeled using realistic equations of state. We find that in these configurations the poloidal field dominates over the toroidal field and that, if the magnetic field is sufficiently strong during the first phases of the stellar life, it can produce large deformations.

  11. RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure.

    Science.gov (United States)

    Pannunzio, Nicholas R; Lieber, Michael R

    2016-05-05

    The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases.

  12. Structure, Stability, and Evolution of Magnetic Flux Ropes from the Perspective of Magnetic Twist

    CERN Document Server

    Liu, Rui; Titov, Viacheslav S; Chen, Jun; Wang, Yuming; Wang, Haimin; Liu, Chang; Xu, Yan; Wiegelmann, Thomas

    2015-01-01

    We investigate the evolution of NOAA Active Region 11817 during 2013 August 10--12, when it developed a complex field configuration and produced four confined, followed by two eruptive, flares. These C-and-above flares are all associated with a magnetic flux rope (MFR) located along the major polarity inversion line, where shearing and converging photospheric flows are present. Aided by the nonlinear force-free field modeling, we identify the MFR through mapping magnetic connectivities and computing the twist number $\\mathcal{T}_w$ for each individual field line. The MFR is moderately twisted ($|\\mathcal{T}_w| < 2$) and has a well-defined boundary of high squashing factor $Q$. We found that the field line with the extremum $|\\mathcal{T}_w|$ is a reliable proxy of the rope axis, and that the MFR's peak $|\\mathcal{T}_w|$ temporarily increases within half an hour before each flare while it decreases after the flare peak for both confined and eruptive flares. This pre-flare increase in $|\\mathcal{T}_w|$ has li...

  13. Noncommutative connections on bimodules and Drinfeld twist deformation

    CERN Document Server

    Aschieri, Paolo

    2012-01-01

    Given a Hopf algebra H, we study modules and bimodules over an algebra A that carry an H-action, as well as their morphisms and connections. Bimodules naturally arise when considering noncommutative analogues of tensor bundles. For quasitriangular Hopf algebras and bimodules with an extra quasi-commutativity property we induce connections on the tensor product over A of two bimodules from connections on the individual bimodules. This construction applies to arbitrary connections, i.e. not necessarily H-equivariant ones, and further extends to the tensor algebra generated by a bimodule and its dual. Examples of these noncommutative structures arise in deformation quantization via Drinfeld twists of the commutative differential geometry of a smooth manifold, where the Hopf algebra H is the universal enveloping algebra of vector fields (or a finitely generated Hopf subalgebra). We extend the Drinfeld twist deformation theory of modules and algebras to morphisms and connections that are not necessarily H-equivari...

  14. Factors That Affect the Degree of Twist in beta-Sheet Structures : A Molecular Dynamics Simulation Study of a Cross-beta Filament of the GNNQQNY Peptide

    NARCIS (Netherlands)

    Periole, Xavier; Rampioni, Aldo; Vendruscolo, Michele; Mark, Alan E.

    2009-01-01

    By exploiting the recent availability of the crystal structure of a cross-beta filament of the GNNQQNY peptide fragment of the yeast prion protein Sup35, possible factors affecting the twisting of beta-sheets structures have been analyzed. The advantage of this system is that it is composed entirely

  15. Twisted baskets.

    Science.gov (United States)

    Hermann, Keith; Pratumyot, Yaowalak; Polen, Shane; Hardin, Alex M; Dalkilic, Erdin; Dastan, Arif; Badjić, Jovica D

    2015-02-23

    A preparative procedure for obtaining a pair of twisted molecular baskets, each comprising a chiral framework with either right ((P)-1syn) or left ((M)-1syn) sense of twist and six ester groups at the rim has been developed and optimized. The racemic (P/M)-1syn can be obtained in three synthetic steps from accessible starting materials. The resolution of (P/M)-1syn is accomplished by its transesterification with (1R,2S,5R)-(-)-menthol in the presence of a Ti(IV) catalyst to give diastereomeric 8(P) and 8(M). It was found that dendritic-like cavitands 8(P) and 8(M), in CD2Cl2, undergo self-inclusion ((1)H NMR spectroscopy) with a menthol moiety occupying the cavity of each host. Importantly, the degree of inclusion of the menthol group was ((1)H NMR spectroscopy) found to be greater in the case of 8(P) than 8(M). Accordingly, it is suggested that different folding characteristic of 8(P) and 8(M) ought to affect the physicochemical characteristics of the hosts to permit their effective separation by column chromatography. The absolute configuration of 8(P)/8(M), encompassing right- and left-handed "cups", was determined with the exciton chirality method and also verified in silico (DFT: B3LYP/TZVP). Finally, the twisted baskets are strongly fluorescent due to three naphthalene chromophores, having a high fluorescence quantum yield within the rigid framework of 8(P)/8(M).

  16. Feasibility Study of Endo- and Exo-skeletal Framed Structures with Envelopes for LTA Platforms

    Science.gov (United States)

    2011-02-15

    1, 2] that the medium altitude LTA airships offer a promising capabilities for CSR based on time on station, all weather capability, flying hour...an endoskeleton envelope with the outer envelope containing the lighter-than-air gas attached to internal ultra lightweight frame with aerodynamic ...Possible Solutions • To avoid wrinkles in the balloon film envelope and to maintain aerodynamic shape, thermoforming of the film can be considered

  17. Bloch spin waves and emergent structure in protein folding with HIV envelope glycoprotein as an example

    Science.gov (United States)

    Dai, Jin; Niemi, Antti J.; He, Jianfeng; Sieradzan, Adam; Ilieva, Nevena

    2016-03-01

    We inquire how structure emerges during the process of protein folding. For this we scrutinize collective many-atom motions during all-atom molecular dynamics simulations. We introduce, develop, and employ various topological techniques, in combination with analytic tools that we deduce from the concept of integrable models and structure of discrete nonlinear Schrödinger equation. The example we consider is an α -helical subunit of the HIV envelope glycoprotein gp41. The helical structure is stable when the subunit is part of the biological oligomer. But in isolation, the helix becomes unstable, and the monomer starts deforming. We follow the process computationally. We interpret the evolving structure both in terms of a backbone based Heisenberg spin chain and in terms of a side chain based XY spin chain. We find that in both cases the formation of protein supersecondary structure is akin the formation of a topological Bloch domain wall along a spin chain. During the process we identify three individual Bloch walls and we show that each of them can be modelled with a precision of tenths to several angstroms in terms of a soliton solution to a discrete nonlinear Schrödinger equation.

  18. Crystal Structure of West Nile Virus Envelope Glycoprotein Reveals Viral Surface Epitopes

    Energy Technology Data Exchange (ETDEWEB)

    Kanai,R.; Kar, K.; Anthony, K.; Gould, L.; Ledizet, M.; Fikrig, E.; Marasco, W.; Koski, R.; Modis, Y.

    2006-01-01

    West Nile virus, a member of the Flavivirus genus, causes fever that can progress to life-threatening encephalitis. The major envelope glycoprotein, E, of these viruses mediates viral attachment and entry by membrane fusion. We have determined the crystal structure of a soluble fragment of West Nile virus E. The structure adopts the same overall fold as that of the E proteins from dengue and tick-borne encephalitis viruses. The conformation of domain II is different from that in other prefusion E structures, however, and resembles the conformation of domain II in postfusion E structures. The epitopes of neutralizing West Nile virus-specific antibodies map to a region of domain III that is exposed on the viral surface and has been implicated in receptor binding. In contrast, we show that certain recombinant therapeutic antibodies, which cross-neutralize West Nile and dengue viruses, bind a peptide from domain I that is exposed only during the membrane fusion transition. By revealing the details of the molecular landscape of the West Nile virus surface, our structure will assist the design of antiviral vaccines and therapeutics.

  19. Vacuum Structure of Twisted Scalar Field Theories on $M^{D-1} \\otimes S^{1}$

    CERN Document Server

    Hatanaka, H; Ohnishi, K; Sakamoto, M

    2001-01-01

    We study scalar field theories on M^{D-1} \\otimes S^1, which allow to impose twisted boundary conditions for the S^1 direction, in detail and report several interesting properties overlooked so far. One of characteristic features is the appearance of critical radii of the circle S^1. A phase transition can occur at the classical level or can be caused by quantum effects. Radiative corrections can restore broken symmetries or can break symmetries for small radius. A surprising feature is that the translational invariance for the S^1 direction can spontaneously be broken. A particular class of coordinate-dependent vacuum configurations is clarified and the O(N) \\phi^4 model on M^{D-1}\\otimes S^1 is extensively studied, as an illustrative example.

  20. From forced collapse to H ii region expansion in Mon R2: Envelope density structure and age determination with Herschel

    CERN Document Server

    Didelon, P; Tremblin, P; Hill, T; Hony, S; Hennemann, M; Hennebelle, P; Anderson, L D; Galliano, F; Schneider, N; Rayner, T; Rygl, K; Louvet, F; Zavagno, A; Konyves, V; Sauvage, M; Andre, Ph; Bontemps, S; Peretto, N; Griffin, M; Gonzalez, M; Lebouteiller, V; Arzoumanian, D; Benedettini, M; Di Francesco, J; Menshchikov, A; Minier, V; Luong, Q Nguyen; Bernard, J -P; Palmeirim, P; Pezzuto, S; Rivera-Ingraham, A; Russeil, D; Ward-Thompson, D; White, G J

    2015-01-01

    The surroundings of HII regions can have a profound influence on their development, morphology, and evolution. This paper explores the effect of the environment on H II regions in the MonR2 molecular cloud. We aim to investigate the density structure of envelopes surrounding HII regions and to determine their collapse and ionisation expansion ages. The Mon R2 molecular cloud is an ideal target since it hosts an H II region association. Column density and temperature images derived from Herschel data were used together to model the structure of HII bubbles and their surrounding envelopes. The resulting observational constraints were used to follow the development of the Mon R2 ionised regions with analytical calculations and numerical simulations. The four hot bubbles associated with H II regions are surrounded by dense, cold, and neutral gas envelopes. The radial density profiles are reminiscent of those of low-mass protostellar envelopes. The inner parts of envelopes of all four HII regions could be free-fal...

  1. Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer

    Directory of Open Access Journals (Sweden)

    Ganjei-Azar Parvin

    2011-03-01

    Full Text Available Abstract Background Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degree of malignancy, and hence acts as a prognostic and predictive indicator of the disease. Furthermore, though the atypical nuclear morphology of cancer cells is believed to be a consequence of oncogenic signaling, the molecular basis remains unclear. Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established. Methods We investigated the expression of the nuclear envelope proteins lamin A/C in ovarian cancer by immunohistochemistry and studied the consequence of lamin A/C suppression using siRNA in primary human ovarian surface epithelial cells in culture. We used immunofluorescence microscopy to analyze nuclear morphology, flow cytometry to analyze cellular DNA content, and fluorescence in situ hybridization to examine cell ploidy of the lamin A/C-suppressed cells. Results We found that nuclear lamina proteins lamin A/C are often absent (47% in ovarian cancer cells and tissues. Even in lamin A/C-positive ovarian cancer, the expression is heterogeneous within the population of tumor cells. In most cancer cell lines, a significant fraction of the lamin A/C-negative population was observed to intermix with the lamin A/C-positive cells. Down regulation of lamin A/C in non-cancerous primary ovarian surface epithelial cells led to morphological deformation and development of aneuploidy. The aneuploid cells became growth retarded due to a p53-dependent induction of the cell cycle inhibitor p21. Conclusions We conclude that the loss of nuclear envelope structural proteins, such as lamin A/C, may underlie two of the hallmarks of cancer - aberrations in nuclear

  2. The twist box domain is required for Twist1-induced prostate cancer metastasis.

    Science.gov (United States)

    Gajula, Rajendra P; Chettiar, Sivarajan T; Williams, Russell D; Thiyagarajan, Saravanan; Kato, Yoshinori; Aziz, Khaled; Wang, Ruoqi; Gandhi, Nishant; Wild, Aaron T; Vesuna, Farhad; Ma, Jinfang; Salih, Tarek; Cades, Jessica; Fertig, Elana; Biswal, Shyam; Burns, Timothy F; Chung, Christine H; Rudin, Charles M; Herman, Joseph M; Hales, Russell K; Raman, Venu; An, Steven S; Tran, Phuoc T

    2013-11-01

    Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial-mesenchymal transition (EMT) that promotes cancer metastasis. Structure-function relationships of Twist1 to cancer-related phenotypes are underappreciated, so we studied the requirement of the conserved Twist box domain for metastatic phenotypes in prostate cancer. Evidence suggests that Twist1 is overexpressed in clinical specimens and correlated with aggressive/metastatic disease. Therefore, we examined a transactivation mutant, Twist1-F191G, in prostate cancer cells using in vitro assays, which mimic various stages of metastasis. Twist1 overexpression led to elevated cytoskeletal stiffness and cell traction forces at the migratory edge of cells based on biophysical single-cell measurements. Twist1 conferred additional cellular properties associated with cancer cell metastasis including increased migration, invasion, anoikis resistance, and anchorage-independent growth. The Twist box mutant was defective for these Twist1 phenotypes in vitro. Importantly, we observed a high frequency of Twist1-induced metastatic lung tumors and extrathoracic metastases in vivo using the experimental lung metastasis assay. The Twist box was required for prostate cancer cells to colonize metastatic lung lesions and extrathoracic metastases. Comparative genomic profiling revealed transcriptional programs directed by the Twist box that were associated with cancer progression, such as Hoxa9. Mechanistically, Twist1 bound to the Hoxa9 promoter and positively regulated Hoxa9 expression in prostate cancer cells. Finally, Hoxa9 was important for Twist1-induced cellular phenotypes associated with metastasis. These data suggest that the Twist box domain is required for Twist1 transcriptional programs and prostate cancer metastasis. Targeting the Twist box domain of Twist1 may effectively limit prostate cancer metastatic potential. ©2013 AACR.

  3. Structural Characterization of N-Alkylated Twisted Amides: Consequences for Amide Bond Resonance and N-C Cleavage.

    Science.gov (United States)

    Hu, Feng; Lalancette, Roger; Szostak, Michal

    2016-04-11

    Herein, we describe the first structural characterization of N-alkylated twisted amides prepared directly by N-alkylation of the corresponding non-planar lactams. This study provides the first experimental evidence that N-alkylation results in a dramatic increase of non-planarity around the amide N-C(O) bond. Moreover, we report a rare example of a molecular wire supported by the same amide C=O-Ag bonds. Reactivity studies demonstrate rapid nucleophilic addition to the N-C(O) moiety of N-alkylated amides, indicating the lack of n(N) to π*(C=O) conjugation. Most crucially, we demonstrate that N-alkylation activates the otherwise unreactive amide bond towards σ N-C cleavage by switchable coordination.

  4. Nucleon spin structure functions at NNLO in the presence of target mass corrections and higher twist effects

    Science.gov (United States)

    Khanpour, Hamzeh; Taheri Monfared, S.; Atashbar Tehrani, S.

    2017-04-01

    We extract polarized parton distribution functions (PPDFs), referred to as "KTA17," together with the highly correlated strong coupling αs from recent and up-to-date g1 and g2 polarized structure functions world data at next-to-next-to-leading order in perturbative QCD. The stability and reliability of the results are ensured by including nonperturbative target mass corrections as well as higher-twist terms which are particularly important at the large-x region at low Q2 . Their role in extracting the PPDFs in the nucleon is studied. Sum rules are discussed and compared with other results from the literature. This analysis is made by means of the Jacobi polynomials expansion technique to the DGLAP evolution. The uncertainties on the observables and on the PPDFs throughout this paper are computed using standard Hessian error propagation which served to provide a more realistic estimate of the PPDFs uncertainties.

  5. Constructive spin-orbital angular momentum coupling can twist materials to create spiral structures in optical vortex illumination

    Energy Technology Data Exchange (ETDEWEB)

    Barada, Daisuke [Graduate School of Engineering, Utsunomiya University, Utsunomiya 321-8585 (Japan); Center for Optical Research and Education (CORE), Utsunomiya University, Utsunomiya 321-8585 (Japan); Juman, Guzhaliayi; Yoshida, Itsuki [Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522 (Japan); Miyamoto, Katsuhiko; Omatsu, Takashige, E-mail: omatsu@faculty.chiba-u.jp [Graduate School of Advanced Integration Science, Chiba University, Chiba 263-8522 (Japan); Molecular Chirality Research Center, Chiba University, Chiba 263-8522 (Japan); Kawata, Shigeo [Graduate School of Engineering, Utsunomiya University, Utsunomiya 321-8585 (Japan); Ohno, Seigo [Graduate School of Science, Tohoku University, Sendai 980-8578 (Japan)

    2016-02-01

    It was discovered that optical vortices twist isotropic and homogenous materials, e.g., azo-polymer films to form spiral structures on a nano- or micro-scale. However, the formation mechanism has not yet been established theoretically. To understand the mechanism of the spiral surface relief formation in the azo-polymer film, we theoretically investigate the optical radiation force induced in an isotropic and homogeneous material under irradiation using a continuous-wave optical vortex with arbitrary topological charge and polarization. It is revealed that the spiral surface relief formation in azo-polymer films requires the irradiation of optical vortices with a positive (negative) spin angular momentum and a positive (negative) orbital angular momentum (constructive spin-orbital angular momentum coupling), i.e., the degeneracy among the optical vortices with the same total angular momentum is resolved.

  6. Comments on the Blumlein-Bottcher determination of higher twist corrections to the nucleon spin structure function g_1

    CERN Document Server

    Leader, Elliot; Stamenov, Dimiter B

    2010-01-01

    In a recent analysis of the world data on polarized DIS, Blumlein and Bottcher conclude that there is no evidence for higher twist contributions, in contrast to the claim of the LSS group, who find evidence for significant higher twist effects. We explain the origin of the apparent contradiction between these results.

  7. A correlational method to concurrently measure envelope and temporal fine structure weights: effects of age, cochlear pathology, and spectral shaping.

    Science.gov (United States)

    Fogerty, Daniel; Humes, Larry E

    2012-09-01

    The speech signal may be divided into spectral frequency-bands, each band containing temporal properties of the envelope and fine structure. This study measured the perceptual weights for the envelope and fine structure in each of three frequency bands for sentence materials in young normal-hearing listeners, older normal-hearing listeners, aided older hearing-impaired listeners, and spectrally matched young normal-hearing listeners. The availability of each acoustic property was independently varied through noisy signal extraction. Thus, the full speech stimulus was presented with noise used to mask six different auditory channels. Perceptual weights were determined by correlating a listener's performance with the signal-to-noise ratio of each acoustic property on a trial-by-trial basis. Results demonstrate that temporal fine structure perceptual weights remain stable across the four listener groups. However, a different weighting typography was observed across the listener groups for envelope cues. Results suggest that spectral shaping used to preserve the audibility of the speech stimulus may alter the allocation of perceptual resources. The relative perceptual weighting of envelope cues may also change with age. Concurrent testing of sentences repeated once on a previous day demonstrated that weighting strategies for all listener groups can change, suggesting an initial stabilization period or susceptibility to auditory training.

  8. Large climate-moderating envelopes for enclosed structures: a preliminary evaluation of energy conservation potential

    Energy Technology Data Exchange (ETDEWEB)

    Wendt, R.L.; Giles, G.E.; Park, J.E.

    1981-12-01

    An investigation was made of the basic impacts of putting a large secondary enclosure around a number of functions and thereby creating a Large Climate Moderating Envelope (LCME). This study is a preliminary estimate of the energy conservation benefits of an LCME. A hypothetical LMCE design was chosen and a coupled fluid dynamic and energy transport analysis was performed to estimate the energy conservation potential of this design. The heat transfer models included insolation, outside air temperature and wind, thermal radiation exchange with the sky, and between the fabric and ground and thermal storage in the earth mass beneath the LCME. The energy transported within the fluid by the buoyancy driven circulation was modeled as an incompressible fluid utilizing the Boussinesq approximation. The climatic conditions were assumed to vary in smooth repeating daily cycles. The numerical simulation of climatic variation was continued until the results within the LCME achieved a repeating daily cycle. The results for selected seasonally characteristic days were utilized to estimate the annual energy consumption of structures within an LCME relative to similar structures exposed to the exterior environment. The relative annual energy savings for summer-dominated climates was estimated to be approx. 70%. The energy savings for a winter-dominated climate LCME were estimated to be somewhat smaller but the LCME concept could offer significant benefits for agricultural applications for this type of climate.

  9. Structural insights into SUN-KASH complexes across the nuclear envelope

    Institute of Scientific and Technical Information of China (English)

    Wenjia Wang; Zhaocai Zhou; Zhubing Shi; Shi Jiao; Cuicui Chen; Huizhen Wang; Guoguang Liu; Qiang Wang; Yun Zhao; Mark I Greene

    2012-01-01

    Linker of the nucleoskeleton and the cytoskeleton (LINC) complexes are composed of SUN and KASH domaincontaining proteins and bridge the inner and outer membranes of the nuclear envelope.LINC complexes play critical roles in nuclear positioning,cell polarization and cellular stiffness.Previously,we reported the homotrimeric structure of human SUN2.We have now determined the crystal structure of the human SUN2-KASH complex.In the complex structure,the SUN domain homotrimer binds to three independent "hook"-like KASH peptides.The overall conformation of the SUN domain in the complex closely resembles the SUN domain in its apo state.A major conformational change involves the AA'-loop of KASH-bound SUN domain,which rearranges to form a mini β-sheet that interacts with the KASH peptide.The PPPT motif of the KASH domain fits tightly into a hydrophobic pocket on the homotrimeric interface of the SUN domain,which we termed the BI-pocket.Moreover,two adjacent protomers of the SUN domain homotrimer sandwich the KASH domain by hydrophobic interaction and hydrogen bonding.Mutations of these binding sites disrupt or reduce the association between the SUN and KASH domains in vitro.In addition,transfection of wild-type,but not mutant,SUN2 promotes cell migration in Ovcar-3 cells.These results provide a structural model of the LINC complex,which is essential for additional study of the physical and functional coupling between the cytoplasm and the nucleoplasm.

  10. Structure Computation of Quiet Spike[Trademark] Flight-Test Data During Envelope Expansion

    Science.gov (United States)

    Kukreja, Sunil L.

    2008-01-01

    System identification or mathematical modeling is used in the aerospace community for development of simulation models for robust control law design. These models are often described as linear time-invariant processes. Nevertheless, it is well known that the underlying process is often nonlinear. The reason for using a linear approach has been due to the lack of a proper set of tools for the identification of nonlinear systems. Over the past several decades, the controls and biomedical communities have made great advances in developing tools for the identification of nonlinear systems. These approaches are robust and readily applicable to aerospace systems. In this paper, we show the application of one such nonlinear system identification technique, structure detection, for the analysis of F-15B Quiet Spike(TradeMark) aeroservoelastic flight-test data. Structure detection is concerned with the selection of a subset of candidate terms that best describe the observed output. This is a necessary procedure to compute an efficient system description that may afford greater insight into the functionality of the system or a simpler controller design. Structure computation as a tool for black-box modeling may be of critical importance for the development of robust parsimonious models for the flight-test community. Moreover, this approach may lead to efficient strategies for rapid envelope expansion, which may save significant development time and costs. The objectives of this study are to demonstrate via analysis of F-15B Quiet Spike aeroservoelastic flight-test data for several flight conditions that 1) linear models are inefficient for modeling aeroservoelastic data, 2) nonlinear identification provides a parsimonious model description while providing a high percent fit for cross-validated data, and 3) the model structure and parameters vary as the flight condition is altered.

  11. 1-, 2-, and 4-Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids: Structure, Thermal Stability, and Fluorescence Relationship

    DEFF Research Database (Denmark)

    Filichev, Vyacheslav V; Astakhova, Irina V.; Malakhov, Andrei D.

    2008-01-01

    A postsynthetic, on-column Sonogashira reaction was applied on DNA molecules modified by 2- or 4-iodophenylmethylglycerol in the middle of the sequence, to give the corresponding ortho- and para-twisted intercalating nucleic acids (TINA) with 1-, 2-, and 4-ethynylpyrene residues. The convenient...... to ortho in homopyrimidine TINAs. Thus, for para-TINAs the bulge insertion of an intercalator led to high thermal stability of Hoogsteen-type parallel triplexes and duplexes, whereas Watson-Cricktype duplexes were destabilized. In the case of ortho-TINA, both Hoogsteen and Watson-Crick-type complexes were...

  12. Midbrain Synchrony to Envelope Structure Supports Behavioral Sensitivity to Single-Formant Vowel-Like Sounds in Noise.

    Science.gov (United States)

    Henry, Kenneth S; Abrams, Kristina S; Forst, Johanna; Mender, Matthew J; Neilans, Erikson G; Idrobo, Fabio; Carney, Laurel H

    2017-02-01

    Vowels make a strong contribution to speech perception under natural conditions. Vowels are encoded in the auditory nerve primarily through neural synchrony to temporal fine structure and to envelope fluctuations rather than through average discharge rate. Neural synchrony is thought to contribute less to vowel coding in central auditory nuclei, consistent with more limited synchronization to fine structure and the emergence of average-rate coding of envelope fluctuations. However, this hypothesis is largely unexplored, especially in background noise. The present study examined coding mechanisms at the level of the midbrain that support behavioral sensitivity to simple vowel-like sounds using neurophysiological recordings and matched behavioral experiments in the budgerigar. Stimuli were harmonic tone complexes with energy concentrated at one spectral peak, or formant frequency, presented in quiet and in noise. Behavioral thresholds for formant-frequency discrimination decreased with increasing amplitude of stimulus envelope fluctuations, increased in noise, and were similar between budgerigars and humans. Multiunit recordings in awake birds showed that the midbrain encodes vowel-like sounds both through response synchrony to envelope structure and through average rate. Whereas neural discrimination thresholds based on either coding scheme were sufficient to support behavioral thresholds in quiet, only synchrony-based neural thresholds could account for behavioral thresholds in background noise. These results reveal an incomplete transformation to average-rate coding of vowel-like sounds in the midbrain. Model simulations suggest that this transformation emerges due to modulation tuning, which is shared between birds and mammals. Furthermore, the results underscore the behavioral relevance of envelope synchrony in the midbrain for detection of small differences in vowel formant frequency under real-world listening conditions.

  13. Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure.

    Directory of Open Access Journals (Sweden)

    Philip R Tedbury

    Full Text Available The matrix (MA domain of HIV-1 Gag plays key roles in membrane targeting of Gag, and envelope (Env glycoprotein incorporation into virions. Although a trimeric MA structure has been available since 1996, evidence for functional MA trimers has been elusive. The mechanism of HIV-1 Env recruitment into virions likewise remains unclear. Here, we identify a point mutation in MA that rescues the Env incorporation defects imposed by an extensive panel of MA and Env mutations. Mapping the mutations onto the putative MA trimer reveals that the incorporation-defective mutations cluster at the tips of the trimer, around the perimeter of a putative gap in the MA lattice into which the cytoplasmic tail of gp41 could insert. By contrast, the rescue mutation is located at the trimer interface, suggesting that it may confer rescue of Env incorporation via modification of MA trimer interactions, a hypothesis consistent with additional mutational analysis. These data strongly support the existence of MA trimers in the immature Gag lattice and demonstrate that rescue of Env incorporation defects is mediated by modified interactions at the MA trimer interface. The data support the hypothesis that mutations in MA that block Env incorporation do so by imposing a steric clash with the gp41 cytoplasmic tail, rather than by disrupting a specific MA-gp41 interaction. The importance of the trimer interface in rescuing Env incorporation suggests that the trimeric arrangement of MA may be a critical factor in permitting incorporation of Env into the Gag lattice.

  14. Effects of ultraviolet radiation on structural components of enveloped RNA viruses

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Mauro R.; Couceiro, Jose N.S.S.; Brito, Sieberth N.; Cabral, Maulori C. [Universidade Federal, Rio de janeiro, RJ (Brazil). Inst. de Microbiologia

    1995-01-01

    The interaction of ultraviolet radiation and virus particles of Western Equine Encephalomyelitis Virus (WEE) and Newcastle Disease Virus (NDV) which have respectively RNA of positive (RNA+) and negative (RNA-) polarity as genomes, was studied using purified particles. The purified virus preparations were irradiated at a range of 1,000 to 6,000 joules per m{sup 2} with posterior analysis of their propagation in primary cells cultures of chicken embryos. It could be observed that a radiation dose of 4,500 joules per m{sup 2} could induce 10{sup 9} TCID50 per ml as minimal loss of titer for WEE virus and NDV. The hemagglutination assay was used as a tool for evaluate the alterations caused by UV radiation on the molecular arrangement of virus proteins. Alterations of the virus hemagglutinating activity were only observed when radiation levels higher than 6,000 joules per m{sup 2} were used. The results from hemolysis assays showed the importance of the loss of the envelope integrity and the damages to nucleoprotein structures during the inactivation process, when we use radiation doses higher than 6,000 joules per m{sup 2}. This model of study can increase our comprehension of the radiation effects on the cell physiology and biological components of the cell membranes. (author). 34 refs., 3 figs., 1 tab.

  15. [Basic types of respiratory system structure in insect egg envelopes, and genes controlling their formation].

    Science.gov (United States)

    Omelina, E S; Baricheva, É M; Fedorova, E V

    2012-01-01

    Insects is a taxon surprisingly rich with species and varieties, and its representatives are considered as the most fitted and "evolutionary successful" living things. Insects are distinguished by diversity and abundance of adaptations to environmental conditions, representatives of this class inhabit different ecological niches, they can be found practically in every corner of the Earth and, in particular, in close adjacency to man. Among them are those who man benefits from and those who man struggles against. This determines man's interest in studying peculiarities of their development as well as adaptations formed by them in the course of evolution to become more viable. In the paper, data are presented on morphological structure of respiratory systems in insect egg envelopes that ensure respiration process of developing embryo. Variability of these systems and their dependence on environmental conditions are demonstrated for different insect species. The information about genes controlling development of respiratory systems in fruit fly eggs is brought together, and occurrence of evolutionary conservative genes participating in development of such systems in other insect species is ascertained.

  16. Envelope structure of Synechococcus sp. WH8113, a nonflagellated swimming cyanobacterium

    Directory of Open Access Journals (Sweden)

    Reese Thomas S

    2001-04-01

    Full Text Available Abstract Background Many bacteria swim by rotating helical flagellar filaments [1]. Waterbury et al. [15] discovered an exception, strains of the cyanobacterium Synechococcus that swim without flagella or visible changes in shape. Other species of cyanobacteria glide on surfaces [2,7]. The hypothesis that Synechococcus might swim using traveling surface waves [6,13] prompted this investigation. Results Using quick-freeze electron microscopy, we have identified a crystalline surface layer that encloses the outer membrane of the motile strain Synechococcus sp. WH8113, the components of which are arranged in a rhomboid lattice. Spicules emerge in profusion from the layer and extend up to 150 nm into the surrounding fluid. These spicules also send extensions inwards to the inner cell membrane where motility is powered by an ion-motive force [17]. Conclusion The envelope structure of Synechococcus sp. WH8113 provides new constraints on its motile mechanism. The spicules are well positioned to transduce energy at the cell membrane into mechanical work at the cell surface. One model is that an unidentified motor embedded in the cell membrane utilizes the spicules as oars to generate a traveling wave external to the surface layer in the manner of ciliated eukaryotes.

  17. Twisted aspirin crystals.

    Science.gov (United States)

    Cui, Xiaoyan; Rohl, Andrew L; Shtukenberg, Alexander; Kahr, Bart

    2013-03-06

    Banded spherulites of aspirin have been crystallized from the melt in the presence of salicylic acid either generated from aspirin decomposition or added deliberately (2.6-35.9 mol %). Scanning electron microscopy, X-ray diffraction analysis, and optical polarimetry show that the spherulites are composed of helicoidal crystallites twisted along the growth directions. Mueller matrix imaging reveals radial oscillations in not only linear birefringence, but also circular birefringence, whose origin is explained through slight (∼1.3°) but systematic splaying of individual lamellae in the film. Strain associated with the replacement of aspirin molecules by salicylic acid molecules in the crystal structure is computed to be large enough to work as the driving force for the twisting of crystallites.

  18. Structure and inhibition of the SARS coronavirus envelope protein ion channel.

    Directory of Open Access Journals (Sweden)

    Konstantin Pervushin

    2009-07-01

    Full Text Available The envelope (E protein from coronaviruses is a small polypeptide that contains at least one alpha-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its morphogenetic properties, protein E has been reported to have membrane permeabilizing activity. Further, the drug hexamethylene amiloride (HMA, but not amiloride, inhibited in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication. We have previously shown for the coronavirus species responsible for severe acute respiratory syndrome (SARS-CoV that the transmembrane domain of E protein (ETM forms pentameric alpha-helical bundles that are likely responsible for the observed channel activity. Herein, using solution NMR in dodecylphosphatidylcholine micelles and energy minimization, we have obtained a model of this channel which features regular alpha-helices that form a pentameric left-handed parallel bundle. The drug HMA was found to bind inside the lumen of the channel, at both the C-terminal and the N-terminal openings, and, in contrast to amiloride, induced additional chemical shifts in ETM. Full length SARS-CoV E displayed channel activity when transiently expressed in human embryonic kidney 293 (HEK-293 cells in a whole-cell patch clamp set-up. This activity was significantly reduced by hexamethylene amiloride (HMA, but not by amiloride. The channel structure presented herein provides a possible rationale for inhibition, and a platform for future structure-based drug design of this potential pharmacological target.

  19. Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop.

    Directory of Open Access Journals (Sweden)

    Masaru Yokoyama

    Full Text Available BACKGROUND: The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular mechanisms underlying the modulation remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: By combining computational and experimental approaches, we examined how V3 net charge could influence the phenotype of the gp120 interaction surface. Molecular dynamics simulations of the identical gp120 outer domain, carrying a V3 loop with net charge of +3 or +7, showed that the V3 change alone could induce global changes in fluctuation and conformation of the loops involved in binding to CD4, coreceptor and antibodies. A neutralization study using the V3 recombinant HIV-1 infectious clones showed that the virus carrying the gp120 with +3 V3, but not with +7 V3, was resistant to neutralization by anti-CD4 binding site monoclonal antibodies. An information entropy study shows that otherwise variable surface of the gp120 outer domain, such as V3 and a region around the CD4 binding loop, are less heterogeneous in the gp120 subpopulation with +3 V3. CONCLUSIONS/SIGNIFICANCE: These results suggest that the HIV-1 gp120 V3 loop acts as an electrostatic modulator that influences the global structure and diversity of the interaction surface of the gp120 outer domain. Our findings will provide a novel structural basis to understand how HIV-1 adjusts relative replication fitness by V3 mutations.

  20. DESIGN OF ENVELOPE STRUCTURES OF BUILDINGS WITH ACCOUNT FOR AND SUBJECT TO THE CONDITIONS OF ACOUSTIC PROTECTION

    Directory of Open Access Journals (Sweden)

    Giyasov Botir Iminzhonovich

    2012-12-01

    Full Text Available The totality of all environmental influences, including domestic and industrial noise, must be taken into account in the design of building structures. Building envelopes that have appropriate acoustic protection properties are to be used in the practice of the acoustic protection (soundproofing, etc.. According to the principles of structural design, design of soundproof buildings can be broken down into the two groups: design with account for the security conditions (eg., windows, doors, walls, floors, and design of noise-proof structures (eg., partitions, suspended ceilings. Multi-optional design of building structures or buildings that meet the terms of acoustic protection requires a modern approach to the process of their development. Any progress in this area is associated with computer-aided design supported by multiple analysis options. Automation allows adjustments in order to comply with the variety of the input data or objective functions to provide for optimal cycling options. In this regard, the authors describe the algorithms and principles of design of building envelopes on the condition of and subject to the acoustic protection. The proposed solution represents a software package capable of performing a multivariate analysis of options of acoustic protection at each stage of building design. Practical application of the software package used to solve practical problems in the design of building envelopes has demonstrated its higher efficiency that the one of traditional design methods.

  1. Modulation of bacterial outer membrane vesicle production by envelope structure and content.

    Science.gov (United States)

    Schwechheimer, Carmen; Kulp, Adam; Kuehn, Meta J

    2014-12-21

    Vesiculation is a ubiquitous secretion process of Gram-negative bacteria, where outer membrane vesicles (OMVs) are small spherical particles on the order of 50 to 250 nm composed of outer membrane (OM) and lumenal periplasmic content. Vesicle functions have been elucidated in some detail, showing their importance in virulence factor secretion, bacterial survival, and biofilm formation in pathogenesis. Furthermore, OMVs serve as an envelope stress response, protecting the secreting bacteria from internal protein misfolding stress, as well as external envelope stressors. Despite their important functional roles very little is known about the regulation and mechanism of vesicle production. Based on the envelope architecture and prior characterization of the hypervesiculation phenotypes for mutants lacking the lipoprotein, Lpp, which is involved in the covalent OM-peptidoglycan (PG) crosslinks, it is expected that an inverse relationship exists between OMV production and PG-crosslinked Lpp. In this study, we found that subtle modifications of PG remodeling and crosslinking modulate OMV production, inversely correlating with bound Lpp levels. However, this inverse relationship was not found in strains in which OMV production is driven by an increase in "periplasmic pressure" resulting from the accumulation of protein, PG fragments, or lipopolysaccharide. In addition, the characterization of an nlpA deletion in backgrounds lacking either Lpp- or OmpA-mediated envelope crosslinks demonstrated a novel role for NlpA in envelope architecture. From this work, we conclude that OMV production can be driven by distinct Lpp concentration-dependent and Lpp concentration-independent pathways.

  2. Structural characteristics correlate with immune responses induced by HIV envelope glycoprotein vaccines.

    Science.gov (United States)

    Sharma, Victoria A; Kan, Elaine; Sun, Yide; Lian, Ying; Cisto, Jimna; Frasca, Verna; Hilt, Susan; Stamatatos, Leonidas; Donnelly, John J; Ulmer, Jeffrey B; Barnett, Susan W; Srivastava, Indresh K

    2006-08-15

    HIV envelope glycoprotein (Env) is the target for inducing neutralizing antibodies. Env is present on the virus surface as a trimer, and, upon binding to CD4, a cascade of events leads to structural rearrangement exposing the co-receptor binding site and entry into the CD4+ host target cells. We have designed monomeric and trimeric Env constructs with and without deletion of the variable loop 2 (ΔV2) from SF162, a subtype B primary isolate, and performed biophysical, biochemical and immunological studies to establish a potential structure–functional relationship. We expressed these Envs in CHO cells, purified the proteins to homogeneity and performed biophysical studies to define the binding properties to CD4, structural characteristics and exposure of epitopes recognized by b12 and CD4i mAb (17B) on both full-length and mutant HIV Env proteins. Parameters evaluated include oligomerization state, number and affinity of CD4 binding sites, enthalpy and entropy of the Env–CD4 interaction and affinity for b12 and 17b mAbs. We observed one CD4 binding site per monomer and three active CD4 binding sites per trimer. A40-fold difference in affinity of the gp120 monomer vs. the o-gp140 trimer towards CD4 was observed (Kd = 58 nM and 1.5 nM, respectively),whereas only a 2-fold difference was observed for the V2 deleted Envs (Kd of gp120ΔV2 = 19 nM, Kd of o-gp140DV2 = 9.3 nM). Monomers had 3-fold higher affinity to the mAb 17b and at least 3-fold weaker affinity to b12 compared to trimers, with gp120DV2 having the weakest affinity for b12 (Kd = 446 nM). Affinity of CD4 binding correlated with proportion of the antibodies induced against the conformational epitopes by the corresponding Envs, and changes in mAb binding correlated with the induction of antibodies directed against linear epitopes. Furthermore,biophysical analysis reveals that the V2 deletion has broad structural implications in the monomer not shared by the trimer, and these changes are reflected in the

  3. Twist planet drive

    Science.gov (United States)

    Vranish, John M. (Inventor)

    1996-01-01

    A planetary gear system includes a sun gear coupled to an annular ring gear through a plurality of twist-planet gears, a speeder gear, and a ground structure having an internal ring gear. Each planet gear includes a solid gear having a first half portion in the form of a spur gear which includes vertical gear teeth and a second half portion in the form of a spur gear which includes helical gear teeth that are offset from the vertical gear teeth and which contact helical gear teeth on the speeder gear and helical gear teeth on the outer ring gear. One half of the twist planet gears are preloaded downward, while the other half are preloaded upwards, each one alternating with the other so that each one twists in a motion opposite to its neighbor when rotated until each planet gear seats against the sun gear, the outer ring gear, the speeder gear, and the inner ring gear. The resulting configuration is an improved stiff anti-backlash gear system.

  4. Expression, refolding and bio-structural analysis of a tetravalent recombinant dengue envelope domain III protein for serological diagnosis.

    Science.gov (United States)

    Combe, Maxime; Lacoux, Xavier; Martinez, Jérôme; Méjan, Odile; Luciani, Françoise; Daniel, Soizic

    2017-03-06

    Dengue is a mosquito-borne disease caused by four genetically and serologically related viruses that affect several millions of people. Envelope domain III (EDIII) of the viral envelope protein contains dengue virus (DENV) type-specific and DENV complex-reactive antigenic sites. Here, we describe the expression in Escherichia coli, the refolding and bio-structural analysis of envelope domain III of the four dengue serotypes as a tetravalent dengue protein (EDIIIT2), generating an attractive diagnostic candidate. In vitro refolding of denatured EDIIIT2 was performed by successive dialysis with decreasing concentrations of chaotropic reagent and in the presence of oxidized glutathione. The efficiency of refolding was demonstrated by protein mobility shifting and fluorescent visualization of labeled cysteine in non-reducing SDS-PAGE. The identity and the fully oxidized state of the protein were verified by mass spectrometry. Analysis of the structure by fluorescence, differential scanning calorimetry and circular dichroism showed a well-formed structural conformation mainly composed of β-strands. A label-free immunoassay based on biolayer interferometry technology was subsequently used to evaluate antigenic properties of folded EDIIIT2 protein using a panel of dengue IgM positive and negative human sera. Our data collectively support the use of an oxidatively refolded EDIIIT2 recombinant chimeric protein as a promising antigen in the serological diagnosis of dengue virus infections.

  5. xF 3(x,Q 2) Structure Function and Gross-Llewellyn Smith Sum Rule with Nuclear Effect and Higher Twist Correction

    Science.gov (United States)

    Nath, N. M.; Mukharjee, A.; Das, M. K.; Sarma, J. K.

    2016-12-01

    We present an analysis of the xF3(x,Q2) structure function and Gross-Llewellyn Smith(GLS) sum rule taking into account the nuclear effects and higher twist correction. This analysis is based on the results presented in [N.M. Nath, et al, Indian J. Phys. 90 (2016) 117]. The corrections due to nuclear effects predicted in several earlier analysis are incorporated to our results of xF3(x,Q2) structure function and GLS sum rule for free nucleon, corrected upto next-next-to-leading order (NNLO) perturbative order and calculate the nuclear structure function as well as sum rule for nuclei. In addition, by means of a simple model we have extracted the higher twist contributions to the non-singlet structure function xF3(x,Q2) and GLS sum rule in NNLO perturbative orders and then incorporated them to our results. Our NNLO results along with nuclear effect and higher twist corrections are observed to be compatible with corresponding experimental data and other phenomenological analysis. Support from DAE-BRNS, India, as Major Research Project under Sanction No. 2012/37P/36/BRNS/2018 dated 24 Nov. 2012

  6. A Search for Higher Twist Effects in the Neutron Spin Structure Function gn2(x,Q2)

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Kevin [College of William and Mary, Williamsburg, VA (United States)

    2003-08-01

    Jefferson Lab experiment E97-103 measured the spin structure function gn2(x,Q2) from a Q2 of 0.58 to 1.36 with a nearly constant x of 0.2. Combining this data with a fit to the world gn1 data, the size of higher twist contributions to the spin structure functions can be extracted using the Wandzura-Wilczek relation. These higher twist contributions result from quark-gluon correlations and are expected to be larger as Q2 decreases. This experiment was performed in Hall A with a longitudinally polarized electron beam and a high density polarized 3He target. The physics motivation and an overview of the experiment will be presented.

  7. Structural and functional analysis of the baculovirus envelope fusion protein F

    NARCIS (Netherlands)

    Wang, Q.

    2015-01-01

    Baculoviruses are enveloped, double-stranded DNA viruses that are pathogenic predominantly to insects. Insects, such as caterpillars, become infected by oral feeding on proteinaceous occlusion bodies (OBs) containing the occlusion-derived virus (ODV) form of the virus. The ODV infects epithelial cel

  8. Structure-function relationship of the baculovirus envelope fusion protein F

    NARCIS (Netherlands)

    Long, G.

    2007-01-01

    Baculoviruses are a large group of enveloped, double-stranded DNA viruses exclusively infectious for arthropods, predominantly insects of the order Lepidoptera. Baculovirology has advanced considerably in recent years as a consequence of the successful use of baculoviruses (i) in biological control

  9. Differential Hopf algebra structures on the universal enveloping algebra ofa Lie algebra

    NARCIS (Netherlands)

    N.W. van den Hijligenberg; R. Martini

    1995-01-01

    textabstractWe discuss a method to construct a De Rham complex (differential algebra) of Poincar'e-Birkhoff-Witt-type on the universal enveloping algebra of a Lie algebra $g$. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebra

  10. Differential Hopf algebra structures on the Universal Enveloping Algebra of a Lie Algebra

    NARCIS (Netherlands)

    van den Hijligenberg, N.W.; van den Hijligenberg, N.; Martini, Ruud

    1995-01-01

    We discuss a method to construct a De Rham complex (differential algebra) of Poincaré–Birkhoff–Witt type on the universal enveloping algebra of a Lie algebra g. We determine the cases in which this gives rise to a differential Hopf algebra that naturally extends the Hopf algebrastructure of U(g).

  11. Noncommutative principal bundles through twist deformation

    CERN Document Server

    Aschieri, Paolo; Pagani, Chiara; Schenkel, Alexander

    2016-01-01

    We construct noncommutative principal bundles deforming principal bundles with a Drinfeld twist (2-cocycle). If the twist is associated with the structure group then we have a deformation of the fibers. If the twist is associated with the automorphism group of the principal bundle, then we obtain noncommutative deformations of the base space as well. Combining the two twist deformations we obtain noncommutative principal bundles with both noncommutative fibers and base space. More in general, the natural isomorphisms proving the equivalence of a closed monoidal category of modules and its twist related one are used to obtain new Hopf-Galois extensions as twists of Hopf-Galois extensions. A sheaf approach is also considered, and examples presented.

  12. Building envelope

    CSIR Research Space (South Africa)

    Gibberd, Jeremy T

    2009-01-01

    Full Text Available This chapter describes the way building envelopes can contribute to developing green buildings and sets out some objectives that could be aimed for. It also proposes a number of approaches that can be used to help design green building envelopes...

  13. From forced collapse to H ii region expansion in Mon R2: Envelope density structure and age determination with Herschel⋆

    Science.gov (United States)

    Didelon, P.; Motte, F.; Tremblin, P.; Hill, T.; Hony, S.; Hennemann, M.; Hennebelle, P.; Anderson, L. D.; Galliano, F.; Schneider, N.; Rayner, T.; Rygl, K.; Louvet, F.; Zavagno, A.; Könyves, V.; Sauvage, M.; André, Ph.; Bontemps, S.; Peretto, N.; Griffin, M.; González, M.; Lebouteiller, V.; Arzoumanian, D.; Bernard, J.-P.; Benedettini, M.; Di Francesco, J.; Men'shchikov, A.; Minier, V.; Nguyên Luong, Q.; Palmeirim, P.; Pezzuto, S.; Rivera-Ingraham, A.; Russeil, D.; Ward-Thompson, D.; White, G. J.

    2015-12-01

    Context. The surroundings of H ii regions can have a profound influence on their development, morphology, and evolution. This paper explores the effect of the environment on H ii regions in the MonR2 molecular cloud. Aims: We aim to investigate the density structure of envelopes surrounding H ii regions and to determine their collapse and ionisation expansion ages. The Mon R2 molecular cloud is an ideal target since it hosts an H ii region association, which has been imaged by the Herschel PACS and SPIRE cameras as part of the HOBYS key programme. Methods: Column density and temperature images derived from Herschel data were used together to model the structure of H ii bubbles and their surrounding envelopes. The resulting observational constraints were used to follow the development of the Mon R2 ionised regions with analytical calculations and numerical simulations. Results: The four hot bubbles associated with H ii regions are surrounded by dense, cold, and neutral gas envelopes, which are partly embedded in filaments. The envelope's radial density profiles are reminiscent of those of low-mass protostellar envelopes. The inner parts of envelopes of all four H ii regions could be free-falling because they display shallow density profiles: ρ(r) ∝ r- q with q ≤slant 1.5. As for their outer parts, the two compact H ii regions show a ρ(r) ∝ r-2 profile, which is typical of the equilibrium structure of a singular isothermal sphere. In contrast, the central UCH ii region shows a steeper outer profile, ρ(r) ∝ r-2.5, that could be interpreted as material being forced to collapse, where an external agent overwhelms the internal pressure support. Conclusions: The size of the heated bubbles, the spectral type of the irradiating stars, and the mean initial neutral gas density are used to estimate the ionisation expansion time, texp ~ 0.1 Myr, for the dense UCH ii and compact H ii regions and ~ 0.35 Myr for the extended H ii region. Numerical simulations with and

  14. Noncommutative geometry in string and twisted Hopf algebra of diffeomorphism

    Science.gov (United States)

    Watamura, Satoshi

    2011-09-01

    We discuss the Hopf algebra structure in string theory and present the twist quantization as a unified formulation of the world sheet quantization of the string and the symmetry of the target spacetime. Applying it to the case with a nonzero B-field background, we explain a method to decompose the twist into two successive twists. There are two different possibilities of decomposition: The first is a natural decomposition from the viewpoint of the twist quantization, leading to a new type of twisted Poincaré symmetry. The second decomposition reveals the relation of our formulation to the twisted Poincaré symmetry on the Moyal type noncommutative space.

  15. Twisted mass lattice QCD

    Energy Technology Data Exchange (ETDEWEB)

    Shindler, A. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2007-07-15

    I review the theoretical foundations, properties as well as the simulation results obtained so far of a variant of the Wilson lattice QCD formulation: Wilson twisted mass lattice QCD. Emphasis is put on the discretization errors and on the effects of these discretization errors on the phase structure for Wilson-like fermions in the chiral limit. The possibility to use in lattice simulations different lattice actions for sea and valence quarks to ease the renormalization patterns of phenomenologically relevant local operators, is also discussed. (orig.)

  16. Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

    Directory of Open Access Journals (Sweden)

    Alexander W. Tarr

    2015-07-01

    Full Text Available In the 26 years since the discovery of Hepatitis C virus (HCV a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct-acting antiviral (DAA regimens with >90% cure rates have become available for treatment of chronic HCV infection in developed nations, representing a significant advance towards global eradication. However, the high cost of these treatments results in highly restricted access in developing nations, where the disease burden is greatest. Additionally, the largely asymptomatic nature of infection facilitates continued transmission in at risk groups and resource constrained settings due to limited surveillance. Consequently a prophylactic vaccine is much needed. The HCV envelope glycoproteins E1 and E2 are located on the surface of viral lipid envelope, facilitate viral entry and are the targets for host immunity, in addition to other functions. Unfortunately, the extreme global genetic and antigenic diversity exhibited by the HCV glycoproteins represents a significant obstacle to vaccine development. Here we review current knowledge of HCV envelope protein structure, integrating knowledge of genetic, antigenic and functional diversity to inform rational immunogen design.

  17. Photonic crystal alloys: a new twist in controlling photonic band structure properties.

    Science.gov (United States)

    Kim, Hee Jin; Kim, Dong-Uk; Roh, Young-Geun; Yu, Jaejun; Jeon, Heonsu; Park, Q-Han

    2008-04-28

    We identified new photonic structures and phenomenon that are analogous to alloy crystals and the associated electronic bandgap engineering. From a set of diamond-lattice microwave photonic crystals of randomly mixed silica and alumina spheres but with a well defined mixing composition, we observed that both bandedges of the L-point bandgap monotonically shifted with very little bowing as the composition was varied. The observed results were in excellent agreement with the virtual crystal approximation theory originally developed for electronic properties of alloy crystals. This result signifies the similarity and correspondence between photonics and electronics.

  18. STRUCTURAL AND TECHNOLOGICAL ASPECTS OF DECREASE IN WIRE ANNEALING AT A TWIST OF A HIGH-STRENGTH METAL CORD

    Directory of Open Access Journals (Sweden)

    V. Р. Fetisov

    2016-01-01

    Full Text Available Deformation by drawing with the raised share of the squeezing tension and application of additional deformation with small degrees in the line of a drawing camp allow to minimize a wire annealing of a cold-deformed wire during a twist of a highstrength metal cord.

  19. Bending and Twisting Springback Prediction in the Punching of the Core for a Lattice Truss Sandwich Structure

    Institute of Scientific and Technical Information of China (English)

    Wenchun JIANG; Bin YANG; Xuewei GUAN; Yun LUO

    2013-01-01

    The finite element method was used to study the springback induced by the punching of the core.In order to simulate the springback accurately,a mixed isotropic-nonlinear kinematic hardening model is used to define the material mechanical behavior during plastic deformation.The effects of the friction coefficient,the plate thickness and the die radius have been investigated.The results show that the springback of the sheet with diamond hole is different from the homogenous sheet.Not only bending springback,but also a twisting springback along the truss is generated because of the non-uniform distribution of the bending stress along the truss length.The plate thickness should be around 1.3 mm with larger friction coefficient and smaller die radius,which is useful to decrease the bending and twisting springback.

  20. Research and analysis on structure of twisted-cube connected network%扭立方体连接网络结构的研究与分析

    Institute of Scientific and Technical Information of China (English)

    王新阳; 梁家荣

    2013-01-01

    Referring to the structure of the crossed cube(CQn)and the definition of pair-related, this paper analyzes the struc-ture character of the twisted-cube connected network(TNn), and proves that TNn is disconnected for n5 and the number of the disconnected nodes is half of nodes in the network. Besides, by analyzing the problems of the twisted-cube connected network, it obtains a new network structure:the twisted crossed cube(TCQn), proves that the network is all connected, and makes some preliminary studies on its basic network properties, such as the regularity, connectivity, fault tolerance, recursiveness, and so on, which indicates that the TCQn has the same excellent network properties as the CQn.%根据交叉立方体(CQn)的结构与关联对的概念,对扭立方体连接网络(TNn)的结构特性进行了分析,证明了当n5时,TNn是不连通的,并且不连通的结点数占整个网络结点数的一半。通过分析扭立方体连接网络的错误所在,提出了一种新型网络结构--扭交叉立方体(TCQn),证明了该网络结构是完全连通的,初步研究了其基本网络性质,如正则性,连通度,容错度,递归性等,表明TCQn具有与CQn同样优秀的网络性质。

  1. Snyder noncommutativity and pseudo-Hermitian Hamiltonians from a Jordanian twist

    Energy Technology Data Exchange (ETDEWEB)

    Castro, P.G., E-mail: pgcastro@cbpf.b [Universidade Federal de Juiz de Fora (DM/ICE/UFJF), Juiz de Fora, MG (Brazil). Inst. de Ciencias Exatas. Dept. de Matematica; Kullock, R.; Toppan, F., E-mail: ricardokl@cbpf.b, E-mail: toppan@cbpf.b [Centro Brasileiro de Pesquisas Fisicas (TEO/CBPF), Rio de Janeiro, RJ (Brazil). Coordenacao de Fisica Teorica

    2011-07-01

    Nonrelativistic quantum mechanics and conformal quantum mechanics are de- formed through a Jordanian twist. The deformed space coordinates satisfy the Snyder noncommutativity. The resulting deformed Hamiltonians are pseudo-Hermitian Hamiltonians of the type discussed by Mostafazadeh. The quantization scheme makes use of the so-called 'unfolded formalism' discussed in previous works. A Hopf algebra structure, compatible with the physical interpretation of the coproduct, is introduced for the Universal Enveloping Algebra of a suitably chosen dynamical Lie algebra (the Hamiltonian is contained among its generators). The multi-particle sector, uniquely determined by the deformed 2-particle Hamiltonian, is composed of bosonic particles. (author)

  2. Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.

    Science.gov (United States)

    Meyerson, Joel R; White, Tommi A; Bliss, Donald; Moran, Amy; Bartesaghi, Alberto; Borgnia, Mario J; de la Cruz, M Jason V; Schauder, David; Hartnell, Lisa M; Nandwani, Rachna; Dawood, Moez; Kim, Brianna; Kim, Jun Hong; Sununu, John; Yang, Lisa; Bhatia, Siddhant; Subramaniam, Carolyn; Hurt, Darrell E; Gaudreault, Laurent; Subramaniam, Sriram

    2011-12-01

    Since its discovery nearly 30 years ago, more than 60 million people have been infected with the human immunodeficiency virus (HIV) (www.usaid.gov). The virus infects and destroys CD4+ T-cells thereby crippling the immune system, and causing an acquired immunodeficiency syndrome (AIDS) (2). Infection begins when the HIV Envelope glycoprotein "spike" makes contact with the CD4 receptor on the surface of the CD4+ T-cell. This interaction induces a conformational change in the spike, which promotes interaction with a second cell surface co-receptor (5,9). The significance of these protein interactions in the HIV infection pathway makes them of profound importance in fundamental HIV research, and in the pursuit of an HIV vaccine. The need to better understand the molecular-scale interactions of HIV cell contact and neutralization motivated the development of a technique to determine the structures of the HIV spike interacting with cell surface receptor proteins and molecules that block infection. Using cryo-electron tomography and 3D image processing, we recently demonstrated the ability to determine such structures on the surface of native virus, at ˜20 Å resolution (9,14). This approach is not limited to resolving HIV Envelope structures, and can be extended to other viral membrane proteins and proteins reconstituted on a liposome. In this protocol, we describe how to obtain structures of HIV envelope glycoproteins starting from purified HIV virions and proceeding stepwise through preparing vitrified samples, collecting, cryo-electron microscopy data, reconstituting and processing 3D data volumes, averaging and classifying 3D protein subvolumes, and interpreting results to produce a protein model. The computational aspects of our approach were adapted into modules that can be accessed and executed remotely using the Biowulf GNU/Linux parallel processing cluster at the NIH (http://biowulf.nih.gov). This remote access, combined with low-cost computer hardware and

  3. Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging

    Science.gov (United States)

    Meyerson, Joel R.; White, Tommi A.; Bliss, Donald; Moran, Amy; Bartesaghi, Alberto; Borgnia, Mario J.; de la Cruz, M. Jason V.; Schauder, David; Hartnell, Lisa M.; Nandwani, Rachna; Dawood, Moez; Kim, Brianna; Kim, Jun Hong; Sununu, John; Yang, Lisa; Bhatia, Siddhant; Subramaniam, Carolyn; Hurt, Darrell E.; Gaudreault, Laurent; Subramaniam, Sriram

    2011-01-01

    Since its discovery nearly 30 years ago, more than 60 million people have been infected with the human immunodeficiency virus (HIV) (www.usaid.gov). The virus infects and destroys CD4+ T-cells thereby crippling the immune system, and causing an acquired immunodeficiency syndrome (AIDS) 2. Infection begins when the HIV Envelope glycoprotein "spike" makes contact with the CD4 receptor on the surface of the CD4+ T-cell. This interaction induces a conformational change in the spike, which promotes interaction with a second cell surface co-receptor 5,9. The significance of these protein interactions in the HIV infection pathway makes them of profound importance in fundamental HIV research, and in the pursuit of an HIV vaccine. The need to better understand the molecular-scale interactions of HIV cell contact and neutralization motivated the development of a technique to determine the structures of the HIV spike interacting with cell surface receptor proteins and molecules that block infection. Using cryo-electron tomography and 3D image processing, we recently demonstrated the ability to determine such structures on the surface of native virus, at ˜20 Å resolution 9,14. This approach is not limited to resolving HIV Envelope structures, and can be extended to other viral membrane proteins and proteins reconstituted on a liposome. In this protocol, we describe how to obtain structures of HIV envelope glycoproteins starting from purified HIV virions and proceeding stepwise through preparing vitrified samples, collecting, cryo-electron microscopy data, reconstituting and processing 3D data volumes, averaging and classifying 3D protein subvolumes, and interpreting results to produce a protein model. The computational aspects of our approach were adapted into modules that can be accessed and executed remotely using the Biowulf GNU/Linux parallel processing cluster at the NIH (http://biowulf.nih.gov). This remote access, combined with low-cost computer hardware and high

  4. Generalised twisted partition functions

    CERN Document Server

    Petkova, V B

    2001-01-01

    We consider the set of partition functions that result from the insertion of twist operators compatible with conformal invariance in a given 2D Conformal Field Theory (CFT). A consistency equation, which gives a classification of twists, is written and solved in particular cases. This generalises old results on twisted torus boundary conditions, gives a physical interpretation of Ocneanu's algebraic construction, and might offer a new route to the study of properties of CFT.

  5. Wire harness twisting aid

    Science.gov (United States)

    Casey, E. J.; Commadore, C. C.; Ingles, M. E.

    1980-01-01

    Long wire bundles twist into uniform spiral harnesses with help of simple apparatus. Wires pass through spacers and through hand-held tool with hole for each wire. Ends are attached to low speed bench motor. As motor turns, operator moves hand tool away forming smooth twists in wires between motor and tool. Technique produces harnesses that generate less radio-frequency interference than do irregularly twisted cables.

  6. Twisted network programming essentials

    CERN Document Server

    Fettig, Abe

    2005-01-01

    Twisted Network Programming Essentials from O'Reilly is a task-oriented look at this new open source, Python-based technology. The book begins with recommendations for various plug-ins and add-ons to enhance the basic package as installed. It then details Twisted's collection simple network protocols, and helper utilities. The book also includes projects that let you try out the Twisted framework for yourself. For example, you'll find examples of using Twisted to build web services applications using the REST architecture, using XML-RPC, and using SOAP. Written for developers who want to s

  7. Geometric and Kinematic Structure of the Outflow/Envelope System of L1527 Revealed by Subarcsecond-resolution Observation of CS

    CERN Document Server

    Oya, Yoko; Lefloch, Bertrand; López-Sepulvre, Ana; Watanabe, Yoshimasa; Ceccarelli, Cecilia; Yamamoto, Satoshi

    2016-01-01

    Subarcsecond-resolution images of the rotational line emissions of CS and c-C$_3$H$_2$ obtained toward the low-mass protostar IRAS 04368$+$2557 in L1527 with the Atacama Large Millimeter/submillimeter Array are investigated to constrain the orientation of the outflow/envelope system. The distribution of CS consists of an envelope component extending from north to south and a faint butterfly-shaped outflow component. The kinematic structure of the envelope is well reproduced by a simple ballistic model of an infalling rotating envelope. Although the envelope has a nearly edge-on configuration, the inclination angle of the rotation axis from the plane of the sky is found to be 5$^\\circ$, where we find that the western side of the envelope faces the observer. This configuration is opposite to the direction of the large-scale ($\\sim$ 10$^4$ AU) outflow suggested previously from the $^{12}$CO ($J$=3$-$2) observation, and to the morphology of infrared reflection near the protostar ($\\sim$ 200 AU). The latter discre...

  8. Kinematic structure of the atmosphere and envelope of the post-AGB star HD56126

    CERN Document Server

    Klochkova, Valentina

    2007-01-01

    We present results of an analysis of the optical spectrum of the post-AGB star HD56126 (IRAS 07134+1005) based on observations made with the echelle spectrographs of the 6-m telescope with spectral resolutions of R=25000 and 60000 at 4012-8790 AA. The profiles of strongest lines (HI; FeII, YII, BaII absorptions, etc.) formed in the expanding atmosphere at the base of the stellar wind have complex and variable shapes. To study the kinematics of the atmosphere, the velocities of individual features in these profiles must be measured. Differential line shifts of up to Vr=15-30 km/s have been detected from the lines of metals and molecular features. The star's atmosphere simultaneously contains both expanding layers and layers falling onto the star. A comparison of the data for different times demonstrates that both the radial velocity and the velocity pattern in whole are variable. The position of the molecular spectrum is stable, implying stability of the expansion velocity of the circumstellar envelope around ...

  9. The HIFI spectral survey of AFGL 2591 (CHESS). III. Chemical structure of the protostellar envelope

    CERN Document Server

    Kazmierczak-Barthel, Maja; van der Tak, Floris; Chavarría, Luis; van der Wiel, Matthijs

    2014-01-01

    We aim to understand the rich chemical composition of AFGL 2591, a prototypical isolated high-mass star-forming region. Based on HIFI and JCMT data, the molecular abundances of species found in the protostellar envelope of AFGL 2591 were derived with the Monte Carlo radiative transfer code RATRAN, assuming either constant values or 1D stepwise radial profiles as abundance distributions. The reconstructed 1D abundances were compared with the results of time-dependent gas-grain chemical modeling, considering ages of 10,000 to 50,000 years, cosmic-ray ionization rates of 0.5 to 50 times 10^-16 s^-1, uniformly-sized 0.1-1 micron dust grains, a dust/gas ratio of 1%, and several sets of initial molecular abundances with C/O 1. Constant abundance models give good fits to the data for CO, CN, CS, HCO+, H2CO, N2H+, C2H, NO, OCS, OH, H2CS, O, C, C+, and CH. Models with an abundance jump at 100 K give good fits to the data for NH3, SO, SO2, H2S, H2O, HCl, and CH3OH. For HCN and HNC, the best models have an abundance jum...

  10. Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhigang; Wang, Yong; Brunzelle, Joseph; Kovari, Iulia A.; Kovari, Ladislau C. (WSU-MED); (NWU)

    2012-03-27

    Under drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease.

  11. Next-to-next-to-leading order QCD analysis of the revised CCFR data for $xF_3$ structure function and the higher twist contributions

    CERN Document Server

    Kataev, A L; Parente, G; Sidorov, A V

    1998-01-01

    We present the results of the next-to-next-to-leading order QCD analysis of the recently revised experimental data of the CCFR collaboration for the $xF_3$ structure function using the Jacobi polynomial expansion method. The effects of the higher twist contributions are included into the fits following the infrared renormalon motivated model. The special attention is paid to the checks of the predictive abilities of the infrared renormalon model and to the independent extraction of the $x$-shape of the twist-4 contributions to the $xF_3$ structure function in the process of the leading order, next-to-leading order and next-to-next-to-leading order fits of the revised CCFR data. We stress that at the next-to-next-to-leading order the results for We obtain the following result $\\alpha_s(M_Z)^{NNLO}=0.117 \\pm 0.002(stat) \\pm 0.005 (syst)\\pm 0.003 (theory)$. The comparison of the outcomes of our next-to-leading order and next-to-next-to-leading order analysis indicate that the theoretical QCD uncertainties were u...

  12. Two new twisted helical nickel(II) and cobalt(III) octahedral monomer complexes: Synthesis and structural characterization

    Indian Academy of Sciences (India)

    Malay Dolai; Mahammad Ali

    2014-11-01

    Two mononuclear complexes namely [NiII(L)] (1) and [CoIII(L)](NO3) (2) of a hexacoordinating N4O2 donor Schiff base ligand were synthesized and characterized by single crystal X-ray studies. In compound 2 the central cobalt is in +3 oxidation state while `in' compound 2, the nickel ion is in +2 oxidation state. The two complexes are isostructural with octahedral coordination environment exhibiting helical twist topology. They also display strong H-bonding as well as CH- interactions to generate 1D chain.

  13. Determining the Secondary Structure of Membrane Proteins and Peptides Via Electron Spin Echo Envelope Modulation (ESEEM) Spectroscopy

    Science.gov (United States)

    Liu, Lishan; Mayo, Daniel J.; Sahu, Indra D.; Zhou, Andy; Zhang, Rongfu; McCarrick, Robert M.; Lorigan, Gary A.

    2016-01-01

    Revealing detailed structural and dynamic information of membrane embedded or associated proteins is challenging due to their hydrophobic nature which makes NMR and X-ray crystallographic studies challenging or impossible. Electron paramagnetic resonance (EPR) has emerged as a powerful technique to provide essential structural and dynamic information for membrane proteins with no size limitations in membrane systems which mimic their natural lipid bilayer environment. Therefore, tremendous efforts have been devoted toward the development and application of EPR spectroscopic techniques to study the structure of biological systems such as membrane proteins and peptides. This chapter introduces a novel approach established and developed in the Lorigan lab to investigate membrane protein and peptide local secondary structures utilizing the pulsed EPR technique electron spin echo envelope modulation (ESEEM) spectroscopy. Detailed sample preparation strategies in model membrane protein systems and the experimental setup are described. Also, the ability of this approach to identify local secondary structure of membrane proteins and peptides with unprecedented efficiency is demonstrated in model systems. Finally, applications and further developments of this ESEEM approach for probing larger size membrane proteins produced by over-expression systems are discussed. PMID:26477255

  14. Overregularity in Oliver Twist

    Institute of Scientific and Technical Information of China (English)

    孔祥曼

    2015-01-01

    Oliver Twist is one of the earliest works of Charles Dickens. In this novel, the author uses many writing skills which impress the readers a lot. This paper gives a brief description of overregularity in Oliver Twist at the phonological and syntactical levels.

  15. Solution Structure Determination of Proteins by Solution NMR: Application to a Envelope Protein, LAP2

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ Recent advances in multidimensional NMR to obtain resonance assignments, interproton distance and torsion angle restraints, and restraints that characterize long range order, coupled with new methods of structure refinement, have permitted solution structures of proteins to be rapidly and quickly determined.

  16. Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

    Energy Technology Data Exchange (ETDEWEB)

    Pancera, Marie; Majeed, Shahzad; Ban, Yih-En Andrew; Chen, Lei; Huang, Chih-chin; Kong, Leopold; Kwon, Young Do; Stuckey, Jonathan; Zhou, Tongqing; Robinson, James E.; Schief, William R.; Sodroski, Joseph; Wyatt, Richard; Kwong, Peter D. (UWASH); (NIH); (Tulane); (DFCI)

    2010-04-15

    The viral spike of HIV-1 is composed of three gp120 envelope glycoproteins attached noncovalently to three gp41 transmembrane molecules. Viral entry is initiated by binding to the CD4 receptor on the cell surface, which induces large conformational changes in gp120. These changes not only provide a model for receptor-triggered entry, but affect spike sensitivity to drug- and antibody-mediated neutralization. Although some of the details of the CD4-induced conformational change have been visualized by crystal structures and cryoelectron tomograms, the critical gp41-interactive region of gp120 was missing from previous atomic-level characterizations. Here we determine the crystal structure of an HIV-1 gp120 core with intact gp41-interactive region in its CD4-bound state, compare this structure to unliganded and antibody-bound forms to identify structurally invariant and plastic components, and use ligand-oriented cryoelectron tomograms to define component mobility in the viral spike context. Newly defined gp120 elements proximal to the gp41 interface complete a 7-stranded {beta}-sandwich, which appeared invariant in conformation. Loop excursions emanating from the sandwich form three topologically separate - and structurally plastic - layers, topped off by the highly glycosylated gp120 outer domain. Crystal structures, cryoelectron tomograms, and interlayer chemistry were consistent with a mechanism in which the layers act as a shape-changing spacer, facilitating movement between outer domain and gp41-associated {beta}-sandwich and providing for conformational diversity used in immune evasion. A 'layered' gp120 architecture thus allows movement among alternative glycoprotein conformations required for virus entry and immune evasion, whereas a {beta}-sandwich clamp maintains gp120-gp41 interaction and regulates gp41 transitions.

  17. Data envelopment analysis a handbook of modeling internal structure and network

    CERN Document Server

    Cook, Wade D

    2014-01-01

    This comprehensive handbook on state-of-the-art topics in DEA modeling of internal structures and networks presents work by leading researchers who share their results on subjects including additive efficiency decomposition and slacks-based network DEA.

  18. Deformed and twisted black holes with NUTs

    CERN Document Server

    Krtous, Pavel; Frolov, Valeri P; Kolar, Ivan

    2015-01-01

    We construct a new class of vacuum black hole solutions whose geometry is deformed and twisted by the presence of NUT charges. The solutions are obtained by `unspinning' the general Kerr-NUT-(A)dS spacetimes, effectively switching off some of their rotation parameters. The resulting geometry has a structure of warped space with the Kerr-like Lorentzian part warped to a Euclidean metric of deformed and/or twisted sphere, with the deformation and twist characterized by the `Euclidean NUT' parameters. In the absence of NUTs, the solution reduces to a well known Kerr-(A)dS black hole with several rotations switched off. New geometries inherit the original symmetry of the Kerr-NUT-(A)dS family, namely, they possess the full Killing tower of hidden and explicit symmetries. As expected, for vanishing NUT, twist, and deformation parameters, the symmetry is further enlarged.

  19. Deformed and twisted black holes with NUTs

    Science.gov (United States)

    Krtouš, Pavel; Kubizňák, David; Frolov, Valeri P.; Kolář, Ivan

    2016-06-01

    We construct a new class of vacuum black hole solutions whose geometry is deformed and twisted by the presence of NUT charges. The solutions are obtained by ‘unspinning’ the general Kerr-NUT-(A)dS spacetimes, effectively switching off some of their rotation parameters. The resulting geometry has a structure of warped space with the Kerr-like Lorentzian part warped to a Euclidean metric of a deformed and/or twisted sphere, with the deformation and twist characterized by the ‘Euclidean NUT’ parameters. In the absence of NUTs, the solution reduces to a well known Kerr-(A)dS black hole with several rotations switched off. New geometries inherit the original symmetry of the Kerr-NUT-(A)dS family, namely, they possess the full Killing tower of hidden and explicit symmetries. As expected, for vanishing NUT, twist, and deformation parameters, the symmetry is further enlarged.

  20. Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, Vinod; Dessau, Moshe; Kucera, Kaury; Anthony, Karen; Ledizet, Michel; Modis, Yorgo; (Yale); (L2 Diagnostics)

    2009-07-31

    Dengue virus relies on a conformational change in its envelope protein, E, to fuse the viral lipid membrane with the endosomal membrane and thereby deliver the viral genome into the cytosol. We have determined the crystal structure of a soluble fragment E (sE) of dengue virus type 1 (DEN-1). The protein is in the postfusion conformation even though it was not exposed to a lipid membrane or detergent. At the domain I-domain III interface, 4 polar residues form a tight cluster that is absent in other flaviviral postfusion structures. Two of these residues, His-282 and His-317, are conserved in flaviviruses and are part of the 'pH sensor' that triggers the fusogenic conformational change in E, at the reduced pH of the endosome. In the fusion loop, Phe-108 adopts a distinct conformation, forming additional trimer contacts and filling the bowl-shaped concavity observed at the tip of the DEN-2 sE trimer.

  1. Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.

    Directory of Open Access Journals (Sweden)

    Tommi A White

    2010-12-01

    Full Text Available The initial step in target cell infection by human, and the closely related simian immunodeficiency viruses (HIV and SIV, respectively occurs with the binding of trimeric envelope glycoproteins (Env, composed of heterodimers of the viral transmembrane glycoprotein (gp41 and surface glycoprotein (gp120 to target T-cells. Knowledge of the molecular structure of trimeric Env on intact viruses is important both for understanding the molecular mechanisms underlying virus-cell interactions and for the design of effective immunogen-based vaccines to combat HIV/AIDS. Previous analyses of intact HIV-1 BaL virions have already resulted in structures of trimeric Env in unliganded and CD4-liganded states at ~20 Å resolution. Here, we show that the molecular architectures of trimeric Env from SIVmneE11S, SIVmac239 and HIV-1 R3A strains are closely comparable to that previously determined for HIV-1 BaL, with the V1 and V2 variable loops located at the apex of the spike, close to the contact zone between virus and cell. The location of the V1/V2 loops in trimeric Env was definitively confirmed by structural analysis of HIV-1 R3A virions engineered to express Env with deletion of these loops. Strikingly, in SIV CP-MAC, a CD4-independent strain, trimeric Env is in a constitutively "open" conformation with gp120 trimers splayed out in a conformation similar to that seen for HIV-1 BaL Env when it is complexed with sCD4 and the CD4i antibody 17b. Our findings suggest a structural explanation for the molecular mechanism of CD4-independent viral entry and further establish that cryo-electron tomography can be used to discover distinct, functionally relevant quaternary structures of Env displayed on intact viruses.

  2. Long-period helical structures and twist-grain boundary phases induced by chemical substitution in the Mn1 -x(Co,Rh ) xGe chiral magnet

    Science.gov (United States)

    Martin, N.; Deutsch, M.; Chaboussant, G.; Damay, F.; Bonville, P.; Fomicheva, L. N.; Tsvyashchenko, A. V.; Rössler, U. K.; Mirebeau, I.

    2017-07-01

    We study the evolution of helical magnetism in MnGe chiral magnet upon partial substitution of Mn for 3 d -Co and 4 d -Rh ions. At high doping levels, we observe spin helices with very long periods—more than ten times larger than in the pure compound—and sizable ordered moments. This behavior calls for a change in the energy balance of interactions leading to the stabilization of the observed magnetic structures. Strikingly, neutron scattering unambiguously shows a double periodicity in the observed spectra at x =0.5 and >0.2 for Co- and Rh-doping, respectively. In analogy with observations made in smectic liquid crystals, we suggest that it may reveal the presence of magnetic "twist grain boundary" phases, involving a dense short-range correlated network of magnetic screw dislocations. The dislocation cores are here tentatively described as smooth textures, made of nonradial double-core skyrmions.

  3. Null twisted geometries

    CERN Document Server

    Speziale, Simone

    2013-01-01

    We define and investigate a quantisation of null hypersurfaces in the context of loop quantum gravity on a fixed graph. The main tool we use is the parametrisation of the theory in terms of twistors, which has already proved useful in discussing the interpretation of spin networks as the quantization of twisted geometries. The classical formalism can be extended in a natural way to null hypersurfaces, with the Euclidean polyhedra replaced by null polyhedra with space-like faces, and SU(2) by the little group ISO(2). The main difference is that the simplicity constraints present in the formalims are all first class, and the symplectic reduction selects only the helicity subgroup of the little group. As a consequence, information on the shapes of the polyhedra is lost, and the result is a much simpler, abelian geometric picture. It can be described by an Euclidean singular structure on the 2-dimensional space-like surface defined by a foliation of space-time by null hypersurfaces. This geometric structure is na...

  4. The structure of SN 1987A's outer circumstellar envelope as probed by light echoes

    Science.gov (United States)

    Crotts, Arlin; Sugerman, Ben; Lawrence, Stephen; Kunkel, William

    2001-05-01

    We present ground-based and HST images processed by image subtraction to highlight transient reflection nebulae or ``light echoes'' of the maximum light pulse of the explosion of SN 1987A from surrounding material. Along with numerous structures already discussed elsewhere, we have found (in multiple epochs of data) a new feature opposite the SN from the mysterious ``Napoleon's Hat'' which indicates a symmetric structure due to shocks internal to the SN's red supergiant wind and probably caused by the pile-up of gas due to differential velocities within the outflow. We also show how echoes betray the ram pressure distribution of the progenitor mass loss flow. .

  5. Twisted analytic torsion

    Institute of Scientific and Technical Information of China (English)

    MATHAI; Varghese

    2010-01-01

    We review the Reidemeister, Ray-Singer’s analytic torsion and the Cheeger-Mller theorem. We describe the analytic torsion of the de Rham complex twisted by a flux form introduced by the current authors and recall its properties. We define a new twisted analytic torsion for the complex of invariant differential forms on the total space of a principal circle bundle twisted by an invariant flux form. We show that when the dimension is even, such a torsion is invariant under certain deformation of the metric and the flux form. Under T-duality which exchanges the topology of the bundle and the flux form and the radius of the circular fiber with its inverse, the twisted torsion of invariant forms are inverse to each other for any dimension.

  6. Twisted Analytic Torsion

    CERN Document Server

    Mathai, Varghese

    2009-01-01

    We review the Reidemeister and Ray-Singer's analytic torsions and the Cheeger-M"uller theorem. We describe the analytic torsion of the de Rham complex twisted by a flux form introduced by the current authors and recall its properties. We define a new twisted analytic torsion for the complex of invariant differential forms on the total space of a principal circle bundle twisted by an invariant flux form. We show that when the dimension is even, such a torsion is invariant under certain deformation of the metric and the flux form. Under T-duality which exchanges the topology of the bundle and the flux form and the radius of the circular fiber with its inverse, the twisted torsions are inverse to each other for any dimensions.

  7. A membrane-like structure envelopes substrate mycelium during colony development in Streptomyces.

    Science.gov (United States)

    García, M

    1995-08-15

    Colonies of Streptomyces antibioticus were studied by transmission and scanning electron microscopy. The micrographs show that substrate mycelium growth takes place among an intercellular material and this mycelium is covered by a surface film. This structure could be a boundary between the aerial mycelium and the substrate mycelium.

  8. Residential Building Envelope Alternatives with Equivalent Cost

    OpenAIRE

    2011-01-01

    Selecting the optimum envelope alternative in buildings is one of the most important factors in ensuring thermal comfort. This study calculated the heating costs, construction and lifecycle costs for a residential building in Istanbul with different envelope alternatives created by changing the type and thickness of the body and insulation materials used in the walls and roof, which are the structural components forming the building envelope. Envelope alternatives with equivalent costs were d...

  9. SAFEGUARDS ENVELOPE

    Energy Technology Data Exchange (ETDEWEB)

    Duc Cao; Richard Metcalf

    2010-07-01

    The Safeguards Envelope is a strategy to determine a set of specific operating parameters within which nuclear facilities may operate to maximize safeguards effectiveness without sacrificing safety or plant efficiency. This paper details advanced statistical techniques that will be applied to real plant process monitoring (PM) data from the Idaho Chemical Processing Plant (ICPP). In a simulation based on this data, multi-tank and multi-attribute correlations were tested against synthetic diversion scenarios. Kernel regression smoothing was used to fit a curve to the historical data, and multivariable, residual analysis and cumulative sum techniques set parameters for operating conditions. Diversion scenarios were created and tested, showing improved results when compared with a previous study utilizing only one-variable Z-testing. A brief analysis of the impact of the safeguards optimization on the rest of plant efficiency, criticality concerns, and overall requirements is presented.

  10. Twisted radio waves and twisted thermodynamics.

    Science.gov (United States)

    Kish, Laszlo B; Nevels, Robert D

    2013-01-01

    We present and analyze a gedanken experiment and show that the assumption that an antenna operating at a single frequency can transmit more than two independent information channels to the far field violates the Second Law of Thermodynamics. Transmission of a large number of channels, each associated with an angular momenta 'twisted wave' mode, to the far field in free space is therefore not possible.

  11. Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair.

    NARCIS (Netherlands)

    Koning, H.D. de; Bogaard, E.H.J. van den; Bergboer, J.G.M.; Kamsteeg, M.; Vlijmen-Willems, I.M.J.J. van; Hitomi, K.; Henry, J.; Simon, M.; Takashita, N.; Ishida-Yamamoto, A.; Schalkwijk, J.; Zeeuwen, P.L.J.M.

    2012-01-01

    BACKGROUND: Recent studies have emphasized the importance of heritable and acquired skin barrier abnormalities in common inflammatory diseases such as psoriasis and atopic dermatitis (AD). To date, no comprehensive studies on the effect of experimental barrier disruption on cornified envelope

  12. Extensive structural change of the envelope protein of dengue virus induced by a tuned ionic strength: conformational and energetic analyses

    Science.gov (United States)

    Degrève, Léo; Fuzo, Carlos A.; Caliri, Antonio

    2012-12-01

    The Dengue has become a global public health threat, with over 100 million infections annually; to date there is no specific vaccine or any antiviral drug. The structures of the envelope (E) proteins of the four known serotype of the dengue virus (DENV) are already known, but there are insufficient molecular details of their structural behavior in solution in the distinct environmental conditions in which the DENVs are submitted, from the digestive tract of the mosquito up to its replication inside the host cell. Such detailed knowledge becomes important because of the multifunctional character of the E protein: it mediates the early events in cell entry, via receptor endocytosis and, as a class II protein, participates determinately in the process of membrane fusion. The proposed infection mechanism asserts that once in the endosome, at low pH, the E homodimers dissociate and insert into the endosomal lipid membrane, after an extensive conformational change, mainly on the relative arrangement of its three domains. In this work we employ all-atom explicit solvent Molecular Dynamics simulations to specify the thermodynamic conditions in that the E proteins are induced to experience extensive structural changes, such as during the process of reducing pH. We study the structural behavior of the E protein monomer at acid pH solution of distinct ionic strength. Extensive simulations are carried out with all the histidine residues in its full protonated form at four distinct ionic strengths. The results are analyzed in detail from structural and energetic perspectives, and the virtual protein movements are described by means of the principal component analyses. As the main result, we found that at acid pH and physiological ionic strength, the E protein suffers a major structural change; for lower or higher ionic strengths, the crystal structure is essentially maintained along of all extensive simulations. On the other hand, at basic pH, when all histidine residues are in

  13. New twist on artificial muscles

    Science.gov (United States)

    Haines, Carter S.; Li, Na; Spinks, Geoffrey M.; Aliev, Ali E.; Di, Jiangtao; Baughman, Ray H.

    2016-01-01

    Lightweight artificial muscle fibers that can match the large tensile stroke of natural muscles have been elusive. In particular, low stroke, limited cycle life, and inefficient energy conversion have combined with high cost and hysteretic performance to restrict practical use. In recent years, a new class of artificial muscles, based on highly twisted fibers, has emerged that can deliver more than 2,000 J/kg of specific work during muscle contraction, compared with just 40 J/kg for natural muscle. Thermally actuated muscles made from ordinary polymer fibers can deliver long-life, hysteresis-free tensile strokes of more than 30% and torsional actuation capable of spinning a paddle at speeds of more than 100,000 rpm. In this perspective, we explore the mechanisms and potential applications of present twisted fiber muscles and the future opportunities and challenges for developing twisted muscles having improved cycle rates, efficiencies, and functionality. We also demonstrate artificial muscle sewing threads and textiles and coiled structures that exhibit nearly unlimited actuation strokes. In addition to robotics and prosthetics, future applications include smart textiles that change breathability in response to temperature and moisture and window shutters that automatically open and close to conserve energy. PMID:27671626

  14. Pushing the Envelope: A Case Study of Building the First Manufactured Home Using Structural Insulated Panels

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, Michael C.; Hadley, Donald L.; Sparkman, Ronald; Lubliner, Michael

    2002-06-01

    This paper for the ACEEE Summer Study describes construction of the first manufactured home ever produced from structural insulated panels. The home was built in July 2000 by Champion Enterprises at its Silverton, Oregon, plant. The house was completed on the assembly line in 9 days including a 300-mile road test. The paper examines the design and approval process leading to the project, the manufacturing process and its adjustment to SIPs, and the transportation and energy performance of the house after it was built. PNNL coordinated this project and conducted long-term monitoring on the house. The WSU Energy Program conducted building diagnostics testing once the house was occupied. PNNL’s and WSU’s involvement was funded by the U.S. DOE Building America Program. The Oregon Office of Energy conducted blower door and duct blaster tests. The completed home was estimated to reduce energy consumption by 50% and to have twice the structural strength required by HUD code for manufactured homes. The demonstration proved that the manufactured home production line could support SIPs production simultaneously with traditional construction and without major modifications, the line work in parallel with SIPs and traditional materials. The project revealed severl possibilities for further improving cost and time savings with SIPs construction, that might translate into increased capacity.

  15. Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope.

    Science.gov (United States)

    Luo, Lu; Wang, Qian; Li, Liang

    2017-09-01

    Perceptual segregation of multiple sounds, which overlap in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct types of signal processing in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Antigenicity of envelop and non-structural proteins of dengue serotypes and their potentiality to elicit specifi antibody

    Directory of Open Access Journals (Sweden)

    Ramesh Venkatachalam

    2015-06-01

    Full Text Available Objective: To find out the antigenic nature of envelop (E and non-structural (NS proteins and their ability to induce specific antibodies, and to investigate specific antibody produced by specific dengue virus (DENV serotypes. Methods: Amino acid sequences of E and NS proteins of dengue serotypes were analysed by using VaxiJen antigen predicition server. The transmembrane of topology analyses were conducted by using transmembrane prediction using hidden markov models. The Hex dock server was used for docking. Results: The antigenicity score and exomembrane potentiality of E and NS proteins were calculated. All those proteins were antigenic; these antigens were made to interact with antibodies such as immunoglobulin A, immunoglobulin G and immunoglobulin M. Higher energy values of immunoglobulin M were found in DENV-1 and DENV-2, and more energy values were found in immunoglobulin G of DENV-3, DENV-4, NS-1, NS-3 and NS-5. Conclusions: In the present study, DENV-1 and DENV-2 are positive to immunoglobulin M and involved in the primary infection. DENV 3, DENV 4 and all the NS proteins (NS-1, NS-3, NS-5 which elicit immunoglobulin G are involved in the secondary infection.

  17. Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein.

    Directory of Open Access Journals (Sweden)

    Aemro Kassa

    Full Text Available Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent structural information has revealed that these conformational transitions are regulated by three conserved but potentially flexible layers stacked between the receptor-binding domain (gp120 and the fusion arm (gp41 of Env. We hypothesized that artificial insertion of a covalent bond will 'snap' Env into a conformation that is less mobile and stably expose conserved sites. Therefore, we analyzed the interface between these gp120 layers (layers 1, 2 and 3 and identified residues that may form disulfide bonds when substituted with cysteines. We subsequently probed the structures of the resultant mutant gp120 proteins by assaying their binding to a variety of ligands using Surface Plasmon Resonance (SPR assay. We found that a single disulfide bond strategically inserted between the highly conserved layers 1 and 2 (C65-C115 is able to 'lock' gp120 in a CD4 receptor bound conformation (in the absence of CD4, as indicated by the lower dissociation constant (Kd for the CD4-induced (CD4i epitope binding 17b antibody. When disulfide-stabilized monomeric (gp120 and trimeric (gp140 Envs were used to immunize rabbits, they were found to elicit a higher proportion of antibodies directed against both CD4i and CD4 binding site epitopes than the wild-type proteins. These results demonstrate that structure-guided stabilization of inter-layer interactions within HIV-1 Env can be used to expose conserved epitopes and potentially overcome the sequence diversity of these molecules.

  18. Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization.

    Science.gov (United States)

    Pace, Vittorio; Holzer, Wolfgang; Meng, Guangrong; Shi, Shicheng; Lalancette, Roger; Szostak, Roman; Szostak, Michal

    2016-10-04

    Herein, we show that acyclic amides that have recently enabled a series of elusive transition-metal-catalyzed N-C activation/cross-coupling reactions are highly twisted around the N-C(O) axis by a new destabilization mechanism of the amide bond. A unique effect of the N-glutarimide substituent, leading to uniformly high twist (ca. 90°) irrespective of the steric effect at the carbon side of the amide bond has been found. This represents the first example of a twisted amide that does not bear significant steric hindrance at the α-carbon atom. The (15) N NMR data show linear correlations between electron density at nitrogen and amide bond twist. This study strongly supports the concept of amide bond ground-state twist as a blueprint for activation of amides toward N-C bond cleavage. The new mechanism offers considerable opportunities for organic synthesis and biological processes involving non-planar amide bonds.

  19. Thermal Activated Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke

    2015-01-01

    search procedure, the combination of materials and their bonding temperature is found in relation to the envelope effect on a thermal environment inside a defined space. This allows the designer to articulate dynamic composites with time-based thermal functionality, related to the material dynamics......, environmental dynamics and occupancy dynamics. Lastly, a physical prototype is created, which illustrates the physical expression of the bi-materials and the problems related to manufacturing of these composite structures....

  20. Population Genetic Structure and Genetic Diversity in Twisted-Jaw Fish, Belodontichthys truncatus Kottelat & Ng, 1999 (Siluriformes: Siluridae, from Mekong Basin

    Directory of Open Access Journals (Sweden)

    Surapon Yodsiri

    2017-01-01

    Full Text Available The Mekong River and its tributaries possess the second highest diversity in fish species in the world. However, the fish biodiversity in this river is threatened by several human activities, such as hydropower plant construction. Understanding the genetic diversity and genetic structure of the species is important for natural resource management. Belodontichthys truncatus Kottelat & Ng is endemic to the Mekong River basin and is an important food source for people in this area. In this study, the genetic diversity, genetic structure, and demographic history of the twisted-jaw fish, B. truncatus, were investigated using mitochondrial cytochrome b gene sequences. A total of 124 fish specimens were collected from 10 locations in the Mekong and its tributaries. Relatively high genetic diversity was found in populations of B. truncatus compared to other catfish species in the Mekong River. The genetic structure analysis revealed that a population from the Chi River in Thailand was genetically significantly different from other populations, which is possibly due to the effect of genetic drift. Demographic history analysis indicated that B. truncatus has undergone recent demographic expansion dating back to the end of the Pleistocene glaciation.

  1. Fine structure of the ommatidia and the occurrence of rhabdomeric twist in the dorsal eye of male Bibio marci (Diptera, Nematocera, Bibionidae).

    Science.gov (United States)

    Altner, I; Burkhardt, D

    1981-01-01

    The ommatidia in the dorsal eye of male Bibio marci (March flies) are comprised of eight retinula cells (R 1--8). In the distal region, the open rhabdomeres of retinula cells 1--6 are arranged in a symmetrically circular pattern with their microvilli directed radially. Immediately beneath the crystalline cone, cell 7 forms a rhabdomere that is about 1 micrometer long and lies in the center of the circle formed by the rhabdomeres of cells 1--6. For the remaining length of an ommatidium it is replaced by the rhabdomere of retinula cell 8. The cell body of this retinula cell almost encloses its own rhabdomere by forming a deep invagination. Consequently, no ommatidial cavity is present. In the left eye rhabdomeres R 3, 5 and 6 first twist clockwise along their longitudinal axes, while rhabdomeres R 1, 2, 4 and 8 twist counterclockwise. Opposite twisting is observed in the right eye. The twist rate varies along the length of the rhabdomeres. In a middle region of 60 micrometers, within which the direction of twist does not change, the maximal twist rates are approximately 2 degrees--5 degrees/micrometers in R 1--6 and even higher in R 8. In a proximal region, the direction of twist is reversed, but the initial orientation of the microvilli not reestablished. Both the cross-sectional shape of the rhabdomeres and their geometric arrangement in the retinula change along with the twisting. It is substantiated that the rhabdomeric twist is not due to artifactual deformation.

  2. Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

    Science.gov (United States)

    Corral-Rodríguez, María Ángeles; Stuiver, Marchel; Abascal-Palacios, Guillermo; Diercks, Tammo; Oyenarte, Iker; Ereño-Orbea, June; de Opakua, Alain Ibáñez; Blanco, Francisco J; Encinar, José Antonio; Spiwok, Vojtêch; Terashima, Hiroyuki; Accardi, Alessio; Müller, Dominik; Martínez-Cruz, Luis Alfonso

    2014-11-15

    Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg2+ extruder at the renal distal convoluted tubule, or its regulator. In the present study, we explore structural features and ligand-binding capacities of the Bateman module of CNNM2 (residues 429-584), an intracellular domain structurally equivalent to the region involved in Mg2+ handling by the bacterial Mg2+ transporter MgtE, and AMP binding by the Mg2+ efflux protein CorC. Additionally, we studied the structural impact of the pathogenic mutation T568I located in this region. Our crystal structures reveal that nucleotides such as AMP, ADP or ATP bind at only one of the two cavities present in CNNM2429-584. Mg2+ favours ATP binding by alleviating the otherwise negative charge repulsion existing between acidic residues and the polyphosphate group of ATP. In crystals CNNM2429-584 forms parallel dimers, commonly referred to as CBS (cystathionine β-synthase) modules. Interestingly, nucleotide binding triggers a conformational change in the CBS module from a twisted towards a flat disc-like structure that mostly affects the structural elements connecting the Bateman module with the transmembrane region. We furthermore show that the T568I mutation, which causes dominant hypomagnesaemia, mimics the structural effect induced by nucleotide binding. The results of the present study suggest that the T568I mutation exerts its pathogenic effect in humans by constraining the conformational equilibrium of the CBS module of CNNM2, which becomes 'locked' in its flat form.

  3. Occurrence and core-envelope structure of 1–4× Earth-size planets around Sun-like stars

    Science.gov (United States)

    Marcy, Geoffrey W.; Weiss, Lauren M.; Petigura, Erik A.; Isaacson, Howard; Howard, Andrew W.; Buchhave, Lars A.

    2014-01-01

    Small planets, 1–4× the size of Earth, are extremely common around Sun-like stars, and surprisingly so, as they are missing in our solar system. Recent detections have yielded enough information about this class of exoplanets to begin characterizing their occurrence rates, orbits, masses, densities, and internal structures. The Kepler mission finds the smallest planets to be most common, as 26% of Sun-like stars have small, 1–2 R⊕ planets with orbital periods under 100 d, and 11% have 1–2 R⊕ planets that receive 1–4× the incident stellar flux that warms our Earth. These Earth-size planets are sprinkled uniformly with orbital distance (logarithmically) out to 0.4 the Earth–Sun distance, and probably beyond. Mass measurements for 33 transiting planets of 1–4 R⊕ show that the smallest of them, R rocky planets. Their densities increase with increasing radius, likely caused by gravitational compression. Including solar system planets yields a relation: ρ=2.32+3.19R/R⊕ [g cm−3]. Larger planets, in the radius range 1.5–4.0 R⊕, have densities that decline with increasing radius, revealing increasing amounts of low-density material (H and He or ices) in an envelope surrounding a rocky core, befitting the appellation ‘‘mini-Neptunes.’’ The gas giant planets occur preferentially around stars that are rich in heavy elements, while rocky planets occur around stars having a range of heavy element abundances. Defining habitable zones remains difficult, without benefit of either detections of life elsewhere or an understanding of life’s biochemical origins. PMID:24912169

  4. Using PKiKP coda to determine inner core structure: 1. Synthesis of coda envelopes using single-scattering theories

    Science.gov (United States)

    Leyton, Felipe; Koper, Keith D.

    2007-05-01

    Previous seismic studies have reported evidence of scattered seismic energy coming from the inner core (IC). This implies that the IC has lateral variations in structure or composition with a scale length of tens of kilometers. In the present study, we focus on synthesizing the coda following precritical PKiKP and try to determine the location of the heterogeneities that produce this coda, using previously reported observations as a guide. Using a single-scattering approximation and ray theory, we generate synthetic PKiKP coda envelopes from six distinctive places inside the Earth: within the lower mantle on the source and receiver side, along the core-mantle boundary on the source and receiver side, along the inner core boundary, and within the inner core. We use two approaches to generate synthetic coda from topography on a boundary surface and one that is appropriate for volumetric scattering. In our computations we calculate the arrival time, ray parameter, and amplitude of the seismic waves and take into account errors in the back azimuth, as well as source and receiver effects. We find that previously reported "spindle"-shaped or growing coda can only be produced from volumetric heterogeneities located in the shallowest 350 km of the IC; however, strong trade-offs between the different parameters describing the volumetric heterogeneities (i.e., characteristic wavelengths, RMS velocity or impedance contrast, and total volume) preclude the determination of a unique model. Additionally, we find that reasonable models of topography at the core-mantle boundary can produce large variations of the PKiKP amplitude due to focusing and defocusing effects. Therefore complexity at the inner core boundary is not necessarily required to account for dramatic amplitude variations in the direct PKiKP amplitudes.

  5. Occurrence and core-envelope structure of 1-4× Earth-size planets around Sun-like stars.

    Science.gov (United States)

    Marcy, Geoffrey W; Weiss, Lauren M; Petigura, Erik A; Isaacson, Howard; Howard, Andrew W; Buchhave, Lars A

    2014-09-02

    Small planets, 1-4× the size of Earth, are extremely common around Sun-like stars, and surprisingly so, as they are missing in our solar system. Recent detections have yielded enough information about this class of exoplanets to begin characterizing their occurrence rates, orbits, masses, densities, and internal structures. The Kepler mission finds the smallest planets to be most common, as 26% of Sun-like stars have small, 1-2 R⊕ planets with orbital periods under 100 d, and 11% have 1-2 R⊕ planets that receive 1-4× the incident stellar flux that warms our Earth. These Earth-size planets are sprinkled uniformly with orbital distance (logarithmically) out to 0.4 the Earth-Sun distance, and probably beyond. Mass measurements for 33 transiting planets of 1-4 R⊕ show that the smallest of them, R planets. Their densities increase with increasing radius, likely caused by gravitational compression. Including solar system planets yields a relation: ρ = 2:32 + 3:19 R=R ⊕ [g cm(-3)]. Larger planets, in the radius range 1.5-4.0 R⊕, have densities that decline with increasing radius, revealing increasing amounts of low-density material (H and He or ices) in an envelope surrounding a rocky core, befitting the appellation ''mini-Neptunes.'' The gas giant planets occur preferentially around stars that are rich in heavy elements, while rocky planets occur around stars having a range of heavy element abundances. Defining habitable zones remains difficult, without benefit of either detections of life elsewhere or an understanding of life's biochemical origins.

  6. The structural basis of actinomycin D-binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats.

    Science.gov (United States)

    Lo, Yu-Sheng; Tseng, Wen-Hsuan; Chuang, Chien-Ying; Hou, Ming-Hon

    2013-04-01

    The potent anticancer drug actinomycin D (ActD) functions by intercalating into DNA at GpC sites, thereby interrupting essential biological processes including replication and transcription. Certain neurological diseases are correlated with the expansion of (CGG)n trinucleotide sequences, which contain many contiguous GpC sites separated by a single G:G mispair. To characterize the binding of ActD to CGG triplet repeat sequences, the structural basis for the strong binding of ActD to neighbouring GpC sites flanking a G:G mismatch has been determined based on the crystal structure of ActD bound to ATGCGGCAT, which contains a CGG triplet sequence. The binding of ActD molecules to GCGGC causes many unexpected conformational changes including nucleotide flipping out, a sharp bend and a left-handed twist in the DNA helix via a two site-binding model. Heat denaturation, circular dichroism and surface plasmon resonance analyses showed that adjacent GpC sequences flanking a G:G mismatch are preferred ActD-binding sites. In addition, ActD was shown to bind the hairpin conformation of (CGG)16 in a pairwise combination and with greater stability than that of other DNA intercalators. Our results provide evidence of a possible biological consequence of ActD binding to CGG triplet repeat sequences.

  7. Resonances and higher twist in polarized lepton-nucleon scattering

    CERN Document Server

    Edelmann, J; Kaiser, N; Weise, W

    2000-01-01

    We present a detailed analysis of resonance contributions in the context of higher twist effects in the moments of the proton spin structure function g_1. For each of these moments, it is found that there exists a characteristic Q^2 region in which (perturbative) higher twist corrections coexist with (non-perturbative) resonance contribution of comparable magnitude.

  8. Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins.

    Science.gov (United States)

    Rashad, Adel A; Keller, Paul A

    2013-07-01

    Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa, Asia, Europe and the Americas. It is having an increasingly major impact on humans with potentially life-threatening and debilitating arthritis. Thus far, neither vaccines nor medications are available to treat or control the virus and therefore, the development of medicinal chemistry is a vital and immediate issue that needs to be addressed. The viral envelope proteins play a major role during infection through mediation of binding and fusion with the infected cell surfaces. The possible binding target sites of the chikungunya virus envelope proteins have not previously been investigated; we describe here for the first time the identification of novel sites for potential binding on the chikungunya glycoprotein complexes and the identification of possible antagonists for these sites through virtual screening using two successive docking scores; FRED docking for fast precise screening, with the top hits then subjected to a ranking scoring using the AUTODOCK algorithm. Both the immature and the mature forms of the chikungunya envelope proteins were included in the study to increase the probability of finding positive and reliable hits. Some small molecules have been identified as good in silico chikungunya virus envelope proteins inhibitors and these could be good templates for drug design targeting this virus.

  9. SpaceTwist

    DEFF Research Database (Denmark)

    Yiu, Man Lung; Jensen, Christian Søndergaard; Xuegang, Huang

    2008-01-01

    -based matching generally fall short in offering practical query accuracy guarantees. Our proposed framework, called SpaceTwist, rectifies these shortcomings for k nearest neighbor (kNN) queries. Starting with a location different from the user's actual location, nearest neighbors are retrieved incrementally...

  10. Reweighting twisted boundary conditions

    CERN Document Server

    Bussone, Andrea; Hansen, Martin; Pica, Claudio

    2015-01-01

    Imposing twisted boundary conditions on the fermionic fields is a procedure extensively used when evaluating, for example, form factors on the lattice. Twisting is usually performed for one flavour and only in the valence, and this causes a breaking of unitarity. In this work we explore the possibility of restoring unitarity through the reweighting method. We first study some properties of the approach at tree level and then we stochastically evaluate ratios of fermionic determinants for different boundary conditions in order to include them in the gauge averages, avoiding in this way the expensive generation of new configurations for each choice of the twisting angle, $\\theta$. As expected the effect of reweighting is negligible in the case of large volumes but it is important when the volumes are small and the twisting angles are large. In particular we find a measurable effect for the plaquette and the pion correlation function in the case of $\\theta=\\pi/2$ in a volume $16\\times 8^3$, and we observe a syst...

  11. The twisted Mellin transform

    OpenAIRE

    Wang, Zuoqin

    2007-01-01

    The "twisted Mellin transform" is a slightly modified version of the usual classical Mellin transform on $L^2(\\mathbb R)$. In this short note we investigate some of its basic properties. From the point of views of combinatorics one of its most important interesting properties is that it intertwines the differential operator, $df/dx$, with its finite difference analogue, $\

  12. Vertical structure of the transition zone from infalling rotating envelope to disc in the Class 0 protostar, IRAS 04368+2557

    Science.gov (United States)

    Sakai, Nami; Oya, Yoko; Higuchi, Aya E.; Aikawa, Yuri; Hanawa, Tomoyuki; Ceccarelli, Cecilia; Lefloch, Bertrand; López-Sepulcre, Ana; Watanabe, Yoshimasa; Sakai, Takeshi; Hirota, Tomoya; Caux, Emmanuel; Vastel, Charlotte; Kahane, Claudine; Yamamoto, Satoshi

    2017-05-01

    We have resolved for the first time the radial and vertical structures of the almost edge-on envelope/disc system of the low-mass Class 0 protostar L1527. For that, we have used Atacama Large Millimetre/submillimetre Array (ALMA) observations with a spatial resolution of 0.25 × 0.13 arcsec2 and 0.37 × 0.23 arcsec2 at 0.8 and 1.2 mm, respectively. The L1527 dust continuum emission has a deconvolved size of 78 × 21 au2, and shows a flared disc-like structure. A thin infalling-rotating envelope is seen in the CCH emission outward of about 150 au, and its thickness is increased by a factor of 2 inward of it. This radius lies between the centrifugal radius (200 au) and the centrifugal barrier of the infalling-rotating envelope (100 au). The gas stagnates in front of the centrifugal barrier and moves towards vertical directions. SO emission is concentrated around and inside the centrifugal barrier. The rotation speed of the SO emitting gas is found to be decelerated around the centrifugal barrier. A part of the angular momentum could be extracted by the gas that moves away from the mid-plane around the centrifugal barrier. If this is the case, the centrifugal barrier would be related to the launching mechanism of low-velocity outflows, such as disc winds.

  13. Enveloping -*-Algebra of a Smooth Frechet Algebra Crossed Product by $\\mathbb{R}, K$-Theory and Differential Structure in *-Algebras

    Indian Academy of Sciences (India)

    Subhash J Bhatt

    2006-05-01

    Given an -tempered strongly continuous action of $\\mathbb{R}$ by continuous $∗$-automorphisms of a Frechet $∗$-algebra , it is shown that the enveloping -*-algebra $E(S(\\mathbb{R},A^∞,))$ of the smooth Schwartz crossed product $S(\\mathbb{R},A^∞,)$ of the Frechet algebra $A^∞$ of $C^∞$-elements of is isomorphic to the -*-crossed product $C^∗(\\mathbb{R}, E(A), )$ of the enveloping -*-algebra () of by the induced action. When is a hermitian $\\mathcal{Q}$-algebra, one gets -theory isomorphism $R K_∗(S(\\mathbb{R},A^∞,))=K_∗(C^∗(\\mathbb{R}, E(A),)$ for the representable -theory of Frechet algebras. An application to the differential structure of a *-algebra defined by densely defined differential seminorms is given.

  14. Twisted electron-acoustic waves in plasmas

    Science.gov (United States)

    Aman-ur-Rehman, Ali, S.; Khan, S. A.; Shahzad, K.

    2016-08-01

    In the paraxial limit, a twisted electron-acoustic (EA) wave is studied in a collisionless unmagnetized plasma, whose constituents are the dynamical cold electrons and Boltzmannian hot electrons in the background of static positive ions. The analytical and numerical solutions of the plasma kinetic equation suggest that EA waves with finite amount of orbital angular momentum exhibit a twist in its behavior. The twisted wave particle resonance is also taken into consideration that has been appeared through the effective wave number qeff accounting for Laguerre-Gaussian mode profiles attributed to helical phase structures. Consequently, the dispersion relation and the damping rate of the EA waves are significantly modified with the twisted parameter η, and for η → ∞, the results coincide with the straight propagating plane EA waves. Numerically, new features of twisted EA waves are identified by considering various regimes of wavelength and the results might be useful for transport and trapping of plasma particles in a two-electron component plasma.

  15. Vibrational spectra, DFT calculations, unusual structure, anomalous CH2 wagging and twisting modes, and phase-dependent conformation of 1,3-disilacyclobutane.

    Science.gov (United States)

    Rishard, Mohamed Z M; Irwin, Richard M; Laane, Jaan

    2007-02-08

    Our previously published infrared and Raman spectra of 1,3-disilacyclobutane (13DSCB) and its 1,1,3,3-d4 isotopomer have been reexamined and partially reassigned on the basis of DFT and ab initio calculations. The calculations confirm previous microwave work that the CSiC angles in the ring are unexpectedly larger than the SiCSi angles. This may arise from the partial charges on the ring atoms. The calculations are in excellent agreement with the observed spectra in both frequency and intensity. They also demonstrate that this molecule has CH2 wagging and twisting vibrations with frequencies below 1000 cm-1, about 200 cm-1 lower than expected. These unprecedented low values can be explained by the decreased slope in the potential energy curves for these vibrations as the sideways motions of the CH2 groups result in attractive forces between the positively charged hydrogens on the carbon atoms and the negatively charged hydrogens on the silicon atoms. The theoretical calculations also confirm the previous conclusions that the individual molecules (vapor) have C2v symmetry whereas in the solid the molecules become planar with D2h symmetry. The vibrational coupling between the ring-angle bending mode and the SiH2 in-phase rocking, which is present for the C2v structure, is forbidden for D2h and hence disappears.

  16. Unraveling cellulose microfibrils: a twisted tale.

    Science.gov (United States)

    Hadden, Jodi A; French, Alfred D; Woods, Robert J

    2013-10-01

    Molecular dynamics (MD) simulations of cellulose microfibrils are pertinent to the paper, textile, and biofuels industries for their unique capacity to characterize dynamic behavior and atomic-level interactions with solvent molecules and cellulase enzymes. While high-resolution crystallographic data have established a solid basis for computational analysis of cellulose, previous work has demonstrated a tendency for modeled microfibrils to diverge from the linear experimental structure and adopt a twisted conformation. Here, we investigate the dependence of this twisting behavior on computational approximations and establish the theoretical basis for its occurrence. We examine the role of solvent, the effect of nonbonded force field parameters [partial charges and van der Waals (vdW) contributions], and the use of explicitly modeled oxygen lone pairs in both the solute and solvent. Findings suggest that microfibril twisting is favored by vdW interactions, and counteracted by both intrachain hydrogen bonds and solvent effects at the microfibril surface.

  17. Helicoids, wrinkles, and loops in twisted ribbons.

    Science.gov (United States)

    Chopin, Julien; Kudrolli, Arshad

    2013-10-25

    We investigate the instabilities of a flat elastic ribbon subject to twist under tension and develop an integrated phase diagram of the observed shapes and transitions. We find that the primary buckling mode switches from being localized longitudinally along the length of the ribbon to transverse above a triple point characterized by a crossover tension that scales with ribbon elasticity and aspect ratio. Far from threshold, the longitudinally buckled ribbon evolves continuously into a self-creased helicoid with focusing of the curvature along the triangular edges. Further twist causes an anomalous transition to loops compared with rods due to the self-rigidity induced by the creases. When the ribbon is twisted under high tension, transverse wrinkles are observed due to the development of compressive stresses with higher harmonics for greater width-to-length ratios. Our results can be used to develop functional structures using a wide range of elastic materials and length scales.

  18. Matrix theory compactifications on twisted tori

    CERN Document Server

    Chatzistavrakidis, Athanasios

    2012-01-01

    We study compactifications of Matrix theory on twisted tori and non-commutative versions of them. As a first step, we review the construction of multidimensional twisted tori realized as nilmanifolds based on certain nilpotent Lie algebras. Subsequently, matrix compactifications on tori are revisited and the previously known results are supplemented with a background of a non-commutative torus with non-constant non-commutativity and an underlying non-associative structure on its phase space. Next we turn our attention to 3- and 6-dimensional twisted tori and we describe consistent backgrounds of Matrix theory on them by stating and solving the conditions which describe the corresponding compactification. Both commutative and non-commutative solutions are found in all cases. Finally, we comment on the correspondence among the obtained solutions and flux compactifications of 11-dimensional supergravity, as well as on relations among themselves, such as Seiberg-Witten maps and T-duality.

  19. Adaptive Architectural Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning

    2010-01-01

    different shape alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock- up concept......Recent years have seen an increasing variety of applications of adaptive architectural structures for improvement of structural performance by recognizing changes in their environments and loads, adapting to meet goals, and using past events to improve future performance or maintain serviceability....... The general scopes of this paper are to develop a new adaptive kinetic architectural structure, particularly a reconfigurable architectural structure which can transform body shape from planar geometries to hyper-surfaces using different control strategies, i.e. a transformation into more than one or two...

  20. Twist deformations leading to kappa-Poincare Hopf algebra and their application to physics

    CERN Document Server

    Jurić, Tajron; Samsarov, Andjelo

    2016-01-01

    We consider two twist operators that lead to kappa-Poincare Hopf algebra, the first being an Abelian one and the second corresponding to a light-like kappa-deformation of Poincare algebra. The advantage of the second one is that it is expressed solely in terms of Poincare generators. In contrast to this, the Abelian twist goes out of the boundaries of Poincare algebra and runs into envelope of the general linear algebra. Some of the physical applications of these two different twist operators are considered. In particular, we use the Abelian twist to construct the statistics flip operator compatible with the action of deformed symmetry group. Furthermore, we use the light-like twist operator to define a star product and subsequently to formulate a free scalar field theory compatible with kappa-Poincare Hopf algebra and appropriate for considering the interacting phi^4 scalar field model on kappa-deformed space.

  1. Twisted Ribbons: Theory, Experiment and Applications

    Science.gov (United States)

    Chopin, Julien; Davidovitch, Benjamin; Silva, Flavio A.; Toledo Filho, Romildo D.; Kudrolli, Arshad

    2014-03-01

    We investigate, experimentally and theoretically, the buckling and wrinkling instabilities of a pre-stretched ribbon upon twisting and propose strategies for the fabrication of structured yarns. Our experiment consists in a thin elastic sheet in the form of a ribbon which is initially stretched by a fixed load and then subjected to a twist by rotating the ends through a prescribed angle. We show that a wide variety of shapes and instabilities can be obtained by simply varying the applied twist and tension. The observed structures which include helicoids with and without longitudinal and transverse wrinkles, and spontaneous creases, can be organized in a phase diagram with the tension and twist angle as control parameters [J. Chopin and A. Kudrolli, PRL (2013)]. Using a far-from-threshold analysis and a slender body approximation, we provide a comprehensive understanding of the longitudinal and transverse instabilities and show that several regimes emerge depending on subtle combinations of loading and geometrical parameters. Further, we show that the wrinkling instabilities can be manipulated to fabricate structured yarns which may be used to encapsulate amorphous materials or serve as efficient reinforcements for cement-based composites. COPPETEC / CNPq - Science Without Border Program

  2. Twisted quantum doubles

    Directory of Open Access Journals (Sweden)

    Daijiro Fukuda

    2004-01-01

    Full Text Available Using diagrammatic pictures of tensor contractions, we consider a Hopf algebra (Aop⊗ℛλA** twisted by an element ℛλ∈A*⊗Aop corresponding to a Hopf algebra morphism λ:A→A. We show that this Hopf algebra is quasitriangular with the universal R-matrix coming from ℛλ when λ2=idA, generalizing the quantum double construction which corresponds to the case λ=idA.

  3. Unraveling the structure of the variola topoisomerase IB-DNA complex: a possible new twist on smallpox therapy.

    Science.gov (United States)

    Osheroff, Neil

    2006-10-01

    Smallpox is a serious and highly contagious disease that is caused by the variola virus. It is one of the most severe infectious human diseases known, with mortality rates as high as 30%. A successful worldwide vaccination program led to the eradication of smallpox in 1980. However, the high transmission rate of variola virus, coupled with the deadly nature of smallpox, makes this virus a potentially devastating weapon for bioterrorism. Currently, there is no specific treatment for smallpox. However, a recent article on the structure of a variola topoisomerase IB-DNA complex provides an intriguing starting point for the rational design of drugs with potential activity against smallpox.

  4. New twist in the theories on the secondary structure dependence and hydration effect of the vibrational properties of peptides

    Science.gov (United States)

    Torii, Hajime

    2016-12-01

    The present paper deals with two aspects in relation to the secondary structure dependence and hydration effect of the vibrational properties of peptides. One is the dependence of the vibrational frequencies and IR intensities of the amide I and II modes on the angular position of hydrating water. Although we have vague expectation for a stretching mode that the frequency becomes lower as the hydrogen bond becomes stronger, the result of the present theoretical calculations on the amide I mode strongly contradicts it. It is shown that we can rationalize this situation by considering the scalar and vector components of the frequency shifts separately. The other is the secondary structure dependence of the IR intensity of the amide II mode. It is enhanced more than twice for the C5 conformation, while it is reduced to about 0.7 times for the α-helix conformation. It is shown from the analysis of the electron density derivatives that the former arises from the inter-peptide charge flux, while the latter arises from the electrostatic polarization effect.

  5. Relatively Flat Envelopes

    Institute of Scientific and Technical Information of China (English)

    丁南庆

    1994-01-01

    The aim of this paper is to investigate relatively flat envelopes. A necessary and sufficient condition is given for a relatively-finitely presented module to have a (mono-morphic or epic) relatively flat envelope. Then those rings are characterized whose every relatively-finitely presented module has a relatively flat envelope which coincides with its in-jective envelope. Some known results are obtained as corollaries.

  6. PCM-enhanced building components an application of phase change materials in building envelopes and internal structures

    CERN Document Server

    Kosny, Jan

    2015-01-01

    Presenting an overview of the use of Phase Change Materials (PCMs) within buildings, this book discusses the performance of PCM-enhanced building envelopes. It reviews the most common PCMs suitable for building applications, and discusses PCM encapsulation and packaging methods. In addition to this, it examines a range of PCM-enhanced building products in the process of development as well as examples of whole-building-scale field demonstrations. Further chapters discuss experimental and theoretical analyses (including available software) to determine dynamic thermal and energy performance ch

  7. The Gravitational Field of a Twisted Skyrmion

    CERN Document Server

    Hadi, Miftachul; Husein, Andri

    2015-01-01

    We study nonlinear sigma model, especially Skyrme model without twist and Skyrme model with twist: twisted Skyrme model. Twist term, $mkz$, is indicated in vortex solution. We are interested to construct a space-time containing a string with Lagrangian plus a twist. To add gravity, we replace $\\eta^{\\mu\

  8. Chapter 11 Unexpected Turns and Twists in Structure/Function of PR-Proteins that Connect Energy Metabolism and Immunity

    KAUST Repository

    Narasimhan, Meena L.

    2009-01-01

    Innate immunity in plants is manifested by a complex array of antimicrobial processes that includes induction of sets of pathogenesis-related (PR) proteins. The availability of genomic data has made clear that each PR-protein family in a species is represented by several genes. Microarray data in public databases show that in most families, including the PR-5 family surveyed here, the expression of only few family members is defense associated. Genetic studies show that depending on their nutrient acquisition strategy, pathogens induce distinct but overlapping sets of PR genes, suggesting a connection to energy or resource allocation. PR-5 proteins have a clearly recognizable structure that is referred to as the thaumatin (THN) domain, which can be overlapped with mammalian Complement 1q-tumor necrosis factor (C1q-TNF) domains such as that of the mammalian hormone adiponectin. The occurrence of THN domain proteins is widespread. Similarities between THN domain proteins and mammalian C1q-TNF family proteins include their ligands and their subcellular locations. Osmotin (tobacco PR-5c) regulates energy balance signaling in mammalian cells by interaction with adiponectin receptors by a pathway that shares components with plant energy and stress signaling pathways. These data suggest additional roles for PR-5 proteins, as scaffolds and/or in signaling, particularly in regulating energy balance. © 2009 Elsevier Ltd. All rights reserved.

  9. Properties of twisted ferromagnetic filaments

    Energy Technology Data Exchange (ETDEWEB)

    Belovs, Mihails; Cebers, Andrejs [University of Latvia, Zellu 8, LV-1002 (Latvia)], E-mail: aceb@tesla.sal.lv

    2009-02-01

    The full set of equations for twisted ferromagnetic filaments is derived. The linear stability analysis of twisted ferromagnetic filament is carried out. Two different types of the buckling instability are found - monotonous and oscillatory. The first in the limit of large twist leads to the shape of filament reminding pearls on the string, the second to spontaneous rotation of the filament, which may constitute the working of chiral microengine.

  10. Resonant spin-flavor precession constraints on the neutrino parameters and the twisting structure of the solar magnetic fields from the solar neutrino data

    Indian Academy of Sciences (India)

    S Dev; Jyoti Dhar Sharma; U C Pandey; S P Sud; B C Chauhan

    2003-07-01

    Resonant spin-flavor precession (RSFP) scenario with twisting solar magnetic fields has been confronted with the solar neutrino data from various ongoing experiments. The anticorrelation apparent in the Homestake solar neutrino data has been taken seriously to constrain ( 2,') parameter space and the twisting profiles of the magnetic field in the convective zone of the Sun. The twisting profiles, thus derived, have been used to calculate the variation of the neutrino detection rates with the solar magnetic activity for the Homestake, Super-Kamiokande and the gallium experiments. It is found that the presence of twisting reduces the degree of anticorrelation in all the solar neutrino experiments. However, the anticorrelation in the Homestake experiment is expected to be more pronounced in this scenario. Moreover, the anticorrelation of the solar neutrino flux emerging from the southern solar hemisphere is expected to be stronger than that for the neutrinos emerging from the northern solar hemispheres.

  11. Twisted spacetime in Einstein gravity

    CERN Document Server

    Zhang, Hongsheng

    2016-01-01

    We find a vacuum stationary twisted solution in four-dimensional Einstein gravity. Its frame dragging angular velocities are antisymmetric with respect to the equatorial plane. It possesses a symmetry of joint inversion of time and parity with respect to the equatorial plane. Its Arnowitt-Deser-Misner (ADM) mass and angular momentum are zero. It is curved but regular all over the manifold. Its Komar mass and Komar angular momentum are also zero. Its infinite red-shift surface coincides with its event horizon, since the event horizon does not rotate. Furthermore we extend this solution to the massive case, and find some similar properties. This solution is a stationary axisymmetric solution, but not Kerr. It explicitly proves that pure Einstein gravity permits different rotational mode other than Kerr. Our results demonstrate that the Einstein theory may have much more rich structures than what we ever imagine.

  12. Small x behavior of parton distributions. A study of higher twist effects

    CERN Document Server

    Illarionov, A Yu; Parente, G; Illarionov, Alexei Yu.; Kotikov, Anatoly V.; Parente, Gonzalo

    2004-01-01

    Higher twist corrections to the structure function F_2 at small x are studied for the case of a flat initial condition for the twist-two QCD evolution in the next-to-leading order approximation. We present an analytical parameterization of the contributions from the twist-two and higher twist operators of the Wilson operator product expansion. Higher twist terms are evaluated using two different approaches, one motivated by BFKL and the other motivated by the renormalon formalism. The results of the latter approach are in very good agreement with deep inelastic scattering data from HERA.

  13. 14 CFR 23.333 - Flight envelope.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flight envelope. 23.333 Section 23.333... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Structure Flight Loads § 23.333 Flight envelope. (a) General. Compliance with the strength requirements of this subpart must be shown...

  14. Thermal Responsive Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke

    2015-01-01

    The paper presents an architectural computational method and model, which, through additive and subtractive processes, create composite elements with bending behaviour based on thermal variations in the surrounding climatic environment. The present effort is focused on the manipulation of assembly...... composite layers and their relative layer lengths thereby embedding the merged material effect to create a responsive behavioural architectural envelope. Copper and polypropylene are used as base materials for the composite structure due to their high differences in thermal expansion, surface emissivity...... alterations, their respective durability and copper’s architectural (visual and transformative) aesthetic qualities. Through the use of an evolutionary solver, the composite structure of the elements are organised to find the bending behaviour specified by and for the thermal environments. The entire model...

  15. Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity.

    Science.gov (United States)

    Midgley, Claire M; Flanagan, Aleksandra; Tran, Hai Bac; Dejnirattisai, Wanwisa; Chawansuntati, Kriangkrai; Jumnainsong, Amonrat; Wongwiwat, Wiyada; Duangchinda, Thaneeya; Mongkolsapaya, Juthathip; Grimes, Jonathan M; Screaton, Gavin R

    2012-05-15

    Dengue virus infections are still increasing at an alarming rate in tropical and subtropical countries, underlying the need for a dengue vaccine. Although it is relatively easy to generate Ab responses to dengue virus, low avidity or low concentrations of Ab may enhance infection of FcR-bearing cells with clinical impact, posing a challenge to vaccine production. In this article, we report the characterization of a mAb, 2H12, which is cross-reactive to all four serotypes in the dengue virus group. Crystal structures of 2H12-Fab in complex with domain III of the envelope protein from three dengue serotypes have been determined. 2H12 binds to the highly conserved AB loop of domain III of the envelope protein that is poorly accessible in the mature virion. 2H12 neutralization varied between dengue serotypes and strains; in particular, dengue serotype 2 was not neutralized. Because the 2H12-binding epitope was conserved, this variation in neutralization highlights differences between dengue serotypes and suggests that significant conformational changes in the virus must take place for Ab binding. Surprisingly, 2H12 facilitated little or no enhancement of infection. These data provide a structural basis for understanding Ab neutralization and enhancement of infection, which is crucial for the development of future dengue vaccines.

  16. Double twist helical nanofilaments in bent-core liquid crystals

    Science.gov (United States)

    Zhang, Cuiyu; Diorio, Nicholas; Lavrentovich, Oleg D.; Jakli, Antal

    2014-03-01

    Cryo-TEM observations on 40-150 nm films of four bent-core liquid crystal materials in their helical nanofilament (HNF) phase show that the filaments get deformed near the substrate, and the subsequent arrays of nanofilaments are not parallel, but twisted with respect to each other. The effect can explain the mysterious properties of the HNF materials, such as structural color and ambidextrous optical activity. The observed double twist structure was not expected in the previous models of this phase. Being principally different from the packing of molecules in the twist grain boundary (TGB) and blue (BP) phases, the double-twist structure of HNF expands the rich word of nanostructured organic materials. This work was financially supported by NSF DMR-0964765 and DMR 1104850. The cryo-TEM facility was supported by the Ohio Research Scholars Program. We are grateful for Prof. G. Heppke and Dr. D. Lotsch for providing the PnOPIMB materials for us.

  17. Twisting formula of epsilon factors

    Indian Academy of Sciences (India)

    SAZZAD ALI BISWAS

    2017-09-01

    For characters of a non-Archimedean local field we have explicit formula for epsilon factors. But in general, we do not have any generalized twisting formula of epsilon factors. In this paper, we give a generalized twisting formula of epsilon factorsvia local Jacobi sums.

  18. Twisted supergravity and its quantization

    CERN Document Server

    Costello, Kevin

    2016-01-01

    Twisted supergravity is supergravity in a background where the bosonic ghost field takes a non-zero value. This is the supergravity counterpart of the familiar concept of twisting supersymmetric field theories. In this paper, we give conjectural descriptions of type IIA and IIB supergravity in $10$ dimensions. Our conjectural descriptions are in terms of the closed-string field theories associated to certain topological string theories, and we conjecture that these topological string theories are twists of the physical string theories. For type IIB, the results of arXiv:1505.6703 show that our candidate twisted supergravity theory admits a unique quantization in perturbation theory. This is despite the fact that the theories, like the original physical theories, are non-renormalizable. Although we do not prove our conjectures, we amass considerable evidence. We find that our candidates for the twisted supergravity theories contain the residual supersymmetry one would expect. We also prove (using heavily a res...

  19. Ab initio structures for 90 degrees -twisted s-trans-1,3-butadiene and cyclooctatetraene: the naked sp2-sp2 bond.

    Science.gov (United States)

    Feller, David; Craig, Norman C; Matlin, Albert R

    2008-03-20

    The bond length of a carbon-carbon sp2-sp2 sigma-bond without the perturbing effects of pi-interactions has been estimated by high level calculations on two prototypical systems: a 90 degrees -twisted form of butadiene and the tub conformer of cyclooctatetraene. The former system yields a value of 1.4818 A, considerably longer than previous estimates. The corresponding bond length in the latter is slightly shorter due to some pi-electron delocalization.

  20. Twisted bialgebroids versus bialgebroids from a Drinfeld twist

    Science.gov (United States)

    Borowiec, Andrzej; Pachoł, Anna

    2017-02-01

    Bialgebroids (respectively Hopf algebroids) are bialgebras (Hopf algebras) over noncommutative rings. Drinfeld twist techniques are particularly useful in the (deformation) quantization of Lie algebras as well as the underlying module algebras (=quantum spaces). A smash product construction combines both of them into the new algebra which, in fact, does not depend on the twist. However, we can turn it into a bialgebroid in a twist-dependent way. Alternatively, one can use Drinfeld twist techniques in a category of bialgebroids. We show that both the techniques indicated in the title—the twisting of a bialgebroid or constructing a bialgebroid from the twisted bialgebra—give rise to the same result in the case of a normalized cocycle twist. This can be useful for the better description of a quantum deformed phase space. We argue that within this bialgebroid framework one can justify the use of deformed coordinates (i.e. spacetime noncommutativity), which are frequently postulated in order to explain quantum gravity effects.

  1. Topological Twisted Sigma Model with H-flux Revisited

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Wu-yen

    2006-08-18

    In this paper we revisit the topological twisted sigma model with H-flux. We explicitly expand and then twist the worldsheet Lagrangian for bi-Hermitian geometry. we show that the resulting action consists of a BRST exact term and pullback terms, which only depend on one of the two generalized complex structures and the B-field. We then discuss the topological feature of the model.

  2. Twisted Radiation by Electrons in Spiral Motion

    CERN Document Server

    Katoh, M; Mirian, N S; Konomi, T; Taira, Y; Kaneyasu, T; Hosaka, M; Yamamoto, N; Mochihashi, A; Takashima, Y; Kuroda, K; Miyamoto, A; Miyamoto, K; Sasaki, S

    2016-01-01

    We theoretically show that a single free electron in circular/spiral motion radiates an electromagnetic wave possessing helical phase structure and carrying orbital angular momentum. We experimentally demonstrate it by double-slit diffraction on radiation from relativistic electrons in spiral motion. We show that twisted photons should be created naturally by cyclotron/synchrotron radiations or Compton scatterings in various situations in astrophysics. We propose promising laboratory vortex photon sources in various wavelengths ranging from radio wave to gamma-rays.

  3. Evolutionary and structural features of the C2, V3 and C3 envelope regions underlying the differences in HIV-1 and HIV-2 biology and infection.

    Directory of Open Access Journals (Sweden)

    Helena Barroso

    Full Text Available BACKGROUND: Unlike in HIV-1 infection, the majority of HIV-2 patients produce broadly reactive neutralizing antibodies, control viral replication and survive as elite controllers. The identification of the molecular, structural and evolutionary footprints underlying these very distinct immunological and clinical outcomes may lead to the development of new strategies for the prevention and treatment of HIV infection. METHODOLOGY/PRINCIPAL FINDINGS: We performed a side-by-side molecular, evolutionary and structural comparison of the C2, V3 and C3 envelope regions from HIV-1 and HIV-2. These regions contain major antigenic targets and are important for receptor binding. In HIV-2, these regions also have immune modulatory properties. We found that these regions are significantly more variable in HIV-1 than in HIV-2. Within each virus, C3 is the most entropic region followed by either C2 (HIV-2 or V3 (HIV-1. The C3 region is well exposed in the HIV-2 envelope and is under strong diversifying selection suggesting that, like in HIV-1, it may harbour neutralizing epitopes. Notably, however, extreme diversification of C2 and C3 seems to be deleterious for HIV-2 and prevent its transmission. Computer modelling simulations showed that in HIV-2 the V3 loop is much less exposed than C2 and C3 and has a retractile conformation due to a physical interaction with both C2 and C3. The concealed and conserved nature of V3 in the HIV-2 is consistent with its lack of immunodominancy in vivo and with its role in preventing immune activation. In contrast, HIV-1 had an extended and accessible V3 loop that is consistent with its immunodominant and neutralizing nature. CONCLUSIONS/SIGNIFICANCE: We identify significant structural and functional constrains to the diversification and evolution of C2, V3 and C3 in the HIV-2 envelope but not in HIV-1. These studies highlight fundamental differences in the biology and infection of HIV-1 and HIV-2 and in their mode of

  4. Disk and Envelope Structure in Class 0 Protostars: II. High Resolution Millimeter Mapping of the Serpens Sample

    CERN Document Server

    Enoch, M L; Duchene, G; Bock, D C; Bolatto, A D; Culverhouse, T L; Kwon, W; Lamb, J W; Leitch, E M; Marrone, D P; Muchovej, S J; Perez, L M; Scott, S L; Teuben, P J; Wright, M C H; Zauderer, B A

    2011-01-01

    We present high-resolution CARMA 230 GHz continuum imaging of nine deeply embedded protostars in the Serpens Molecular Cloud, including six of the nine known Class 0 protostars in Serpens. This work is part of a program to characterize disk and envelope properties for a complete sample of Class 0 protostars in nearby low-mass star forming regions. Here we present CARMA maps and visibility amplitudes as a function of uv-distance for the Serpens sample. Observations are made in the B, C, D, and E antenna configurations, with B configuration observations utilizing the CARMA Paired Antenna Calibration System. Combining data from multiple configurations provides excellent uv-coverage (4-500 klam), allowing us to trace spatial scales from 1e2 to 1e4 AU. We find evidence for compact disk components in all of the observed Class 0 protostars, suggesting that disks form at very early times (t 250 AU, but significant evidence of multiplicity on scales <2000 AU is seen in only one source.

  5. The extended molecular envelope of the asymptotic giant branch star π1 Gruis as seen by ALMA. I. Large-scale kinematic structure and CO excitation properties

    Science.gov (United States)

    Doan, L.; Ramstedt, S.; Vlemmings, W. H. T.; Höfner, S.; De Beck, E.; Kerschbaum, F.; Lindqvist, M.; Maercker, M.; Mohamed, S.; Paladini, C.; Wittkowski, M.

    2017-09-01

    Context. The S-type asymptotic giant branch (AGB) star π1 Gru has a known companion at a separation of 2.̋7 (≈400 AU). Previous observations of the circumstellar envelope (CSE) show strong deviations from spherical symmetry. The envelope structure, including an equatorial torus and a fast bipolar outflow, is rarely seen in the AGB phase and is particularly unexpected in such a wide binary system. Therefore a second, closer companion has been suggested, but the evidence is not conclusive. Aims: The aim is to make a 3D model of the CSE and to constrain the density and temperature distribution using new spatially resolved observations of the CO rotational lines. Methods: We have observed the J = 3-2 line emission from 12CO and 13CO using the compact arrays of the Atacama Large Millimeter/submillimeter Array (ALMA). The new ALMA data, together with previously published 12CO J = 2-1 data from the Submillimeter Array (SMA), and the 12CO J = 5-4 and J = 9-8 lines observed with Herschel/Heterodyne Instrument for the Far-Infrared (HIFI), is modeled with the 3D non-LTE radiative transfer code SHAPEMOL. Results: The data analysis clearly confirms the torus-bipolar structure. The 3D model of the CSE that satisfactorily reproduces the data consists of three kinematic components: a radially expanding torus with velocity slowly increasing from 8 to 13 km s-1 along the equator plane; a radially expanding component at the center with a constant velocity of 14 km s-1; and a fast, bipolar outflow with velocity proportionally increasing from 14 km s-1 at the base up to 100 km s-1 at the tip, following a linear radial dependence. The results are used to estimate an average mass-loss rate during the creation of the torus of 7.7 × 10-7 M⊙ yr-1. The total mass and linear momentum of the fast outflow are estimated at 7.3 × 10-4 M⊙ and 9.6 × 1037 g cm s-1, respectively. The momentum of the outflow is in excess (by a factor of about 20) of what could be generated by radiation

  6. General relativistic neutron stars with twisted magnetosphere

    CERN Document Server

    Pili, A G; Del Zanna, L

    2014-01-01

    Soft Gamma-Ray Repeaters and Anomalous X-Ray Pulsars are extreme manifestations of the most magnetized neutron stars: magnetars. The phenomenology of their emission and spectral properties strongly support the idea that the magnetospheres of these astrophysical objects are tightly twisted in the vicinity of the star. Previous studies on equilibrium configurations have so far focused on either the internal or the external magnetic field configuration, without considering a real coupling between the two fields. Here we investigate numerical equilibrium models of magnetized neutron stars endowed with a confined twisted magnetosphere, solving the general relativistic Grad-Shafranov equation both in the interior and in the exterior of the compact object. A comprehensive study of the parameters space is provided to investigate the effects of different current distributions on the overall magnetic field structure.

  7. Twisted mass QCD at finite temperature

    Energy Technology Data Exchange (ETDEWEB)

    Ilgenfritz, E.M.; Mueller-Preussker, M.; Petschlies, M. [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Lombardo, M.P. [Istituto Nazionale di Fisica Nucleare, LNF, Frascati (Italy); Philipsen, O.; Zeidlewicz, L. [Muenster Univ. (Germany). Inst. fuer Theoretische Physik 1; Sternbeck, A. [Adelaide Univ. (Australia). CSSM School of Chemistry and Physics

    2007-10-15

    We discuss the use of Wilson fermions with twisted mass for simulations of QCD thermodynamics. As a prerequisite for a future analysis of the finite-temperature transition making use of automatic {partial_derivative} (a) improvement, we investigate the phase structure in the space spanned by the hopping parameter {kappa}, the coupling {beta}, and the twisted mass parameter {mu}. We present results for N{sub f}=2 degenerate quarks on a 16{sup 3} x 8 lattice, for which we investigate the possibility of an Aoki phase existing at strong coupling and vanishing {mu}, as well as of a thermal phase transition at moderate gauge couplings and non-vanishing {mu}. (orig.)

  8. Valve-aided twisted Savonius rotor

    Energy Technology Data Exchange (ETDEWEB)

    Jaya Rajkumar, M.; Saha, U.K.

    2006-05-15

    Accessories, such as end plates, deflecting plates, shielding and guide vanes, may increase the power of a Savonius rotor, but make the system structurally complex. In such cases, the rotor can develop a relatively large torque at small rotational speeds and is cheap to build, however it harnesses only a small fraction of the incident wind energy. Another proposition for increasing specific output is to place non-return valves inside the concave side of the blades. Such methods have been studied experimentally with a twisted-blade Thus improving a Savonius rotor's energy capture. This new concept has been named as the 'Valve-Aided Twisted Savonius'rotor. Tests were conducted in a low-speed wind tunnel to evaluate performance. This mechanism is found to be independent of flow direction, and shows potential for large machines. [Author].

  9. Semantic Deviation in Oliver Twist

    Institute of Scientific and Technical Information of China (English)

    康艺凡

    2016-01-01

    Dickens, with his adeptness with language, applies semantic deviation skillfully in his realistic novel Oliver Twist. However, most studies and comments home and abroad on it mainly focus on such aspects as humanity, society, and characters. Therefore, this thesis will take a stylistic approach to Oliver Twist from the perspective of semantic deviation, which is achieved by the use of irony, hyperbole, and pun and analyze how the application of the technique makes the novel attractive.

  10. The joke envelope: a neglected precursor of the psychic envelope concept in Freud's writing.

    Science.gov (United States)

    Spero, Moshe Halevi

    2009-01-01

    The concepts of the primeval skin ego, psychic envelope, and related pre-ego containing and wrapping functions elaborated respectively by Esther Bick, Didier Anzieu, and Francis Tustin occupy an important position in contemporary psychoanalytic theory and clinical practice. The psychic envelope begins as a virtual mental protostructure ("proto" because it is not yet based on fully symbolized representations) that holds the budding mind together pending further developments. With maturity, the enveloping functions adopt symbolized, metaphoric form (for example, the aesthetic use of cloth, the analytic framework), but can regress to more concrete and pathological forms. The aforementioned authors based their ideas on a cluster of specific allusions to the idea of a psychic covering, barrier, or envelope in Freud's work. Yet they neglected one reference, hidden in Freud's analysis of the structure ofjokes and humor: the 'joke envelope"--die witzige Einkleidung. The present essay explores Freud's use of the term Einkleidung, including his intriguing idea that a joke requires three people whereas a dream does not and the fact that Freud nowhere speaks of a "dream envelope. "I take the "joke envelope" beyond its original context and posit a relationship between laughter and the early, normative traumas of breathing, crying, and loss, and the dawn of rhythmic envelopes that enable mentalization. Jokes and joking symbolically repeat the early rupture and rapture of breathing and self-other differentiation and the internalization of maternal containing and envelopment.

  11. Generation and application of the twisted beam with orbital angular momentum

    Institute of Scientific and Technical Information of China (English)

    Mingwei Gao; Chunqing Gao; Zhifeng Lin

    2007-01-01

    The twisted Laguerre-Gaussian beam was generated by transforming of Hermite-Gaussian beams through an optical system consisting of three rotated cylindrical lenses. The intensity distribution and phase structure of the twisted hollow beam were theoretically analyzed by using Collins diffraction integral. By utilizing the method of mode decomposition, the theory of transformation was analyzed. In the experiment,micro particles were trapped and rotated by this twisted beam.

  12. Copper(II)-bis-histidine coordination structure in a fibrillar amyloid β-peptide fragment and model complexes revealed by electron spin echo envelope modulation spectroscopy.

    Science.gov (United States)

    Hernández-Guzmán, Jessica; Sun, Li; Mehta, Anil K; Dong, Jijun; Lynn, David G; Warncke, Kurt

    2013-09-23

    Truncated and mutated amyloid-β (Aβ) peptides are models for systematic study-in homogeneous preparations-of the molecular origins of metal ion effects on Aβ aggregation rates, types of aggregate structures formed, and cytotoxicity. The 3D geometry of bis-histidine imidazole coordination of Cu(II) in fibrils of the nonapetide acetyl-Aβ(13-21)H14A has been determined by powder (14) N electron spin echo envelope modulation (ESEEM) spectroscopy. The method of simulation of the anisotropic combination modulation is described and benchmarked for a Cu(II) -bis-cis-imidazole complex of known structure. The revealed bis-cis coordination mode, and the mutual orientation of the imidazole rings, for Cu(II) in Ac-Aβ(13-21)H14A fibrils are consistent with the proposed β-sheet structural model and pairwise peptide interaction with Cu(II) , with an alternating [-metal-vacancy-]n pattern, along the N-terminal edge. Metal coordination does not significantly distort the intra-β-strand peptide interactions, which provides a possible explanation for the acceleration of Ac-Aβ(13-21)H14A fibrillization by Cu(II) , through stabilization of the associated state and low-reorganization integration of β-strand peptide pair precursors.

  13. Envelopes of Commutative Rings

    Institute of Scientific and Technical Information of China (English)

    Rafael PARRA; Manuel SAOR(I)N

    2012-01-01

    Given a significative class F of commutative rings,we study the precise conditions under which a commutative ring R has an F-envelope.A full answer is obtained when.F is the class of fields,semisimple commutative rings or integral domains.When F is the class of Noetherian rings,we give a full answer when the Krull dimension of R is zero and when the envelope is required to be epimorphic.The general problem is reduced to identifying the class of non-Noetherian rings having a monomorphic Noetherian envelope,which we conjecture is the empty class.

  14. Twist-4 contributions to semi-inclusive deeply inelastic scatterings with polarized beam and target

    CERN Document Server

    Wei, Shu-yi; Chen, Kai-bao; Liang, Zuo-tang

    2016-01-01

    We present for the first time the complete twist-4 result for the semi-inclusive deeply inelastic scattering $e^- N \\to e^-qX$ with polarized electron and proton beams at the tree level of pQCD. The calculations have been carried out using the formulism obtained after collinear expansion where the multiple gluon scattering are taken into account and gauge links are obtained automatically in a systematical way. The results show in particular that there are twist-4 contributions to all the eight twist-2 structure functions for $e^- N \\to e^-hX$ that correspond to the eight twist-2 transverse momentum dependent parton distribution functions. Such higher twist effects could be very significant and therefore have important impacts on extracting these three-dimensional parton distribution functions from the asymmetry data on $e^- N \\to e^-hX$. We suggest also an approximate way for a rough estimation of such higher twist contributions.

  15. Effect of Twisting and Stretching on Magneto Resistance and Spin Filtration in CNTs

    Directory of Open Access Journals (Sweden)

    Anil Kumar Singh

    2017-08-01

    Full Text Available Spin-dependent quantum transport properties in twisted carbon nanotube and stretched carbon nanotube are calculated using density functional theory (DFT and non-equilibrium green’s function (NEGF formulation. Twisting and stretching have no effect on spin transport in CNTs at low bias voltages. However, at high bias voltages the effects are significant. Stretching restricts any spin-up current in antiparallel configuration (APC, which results in higher magneto resistance (MR. Twisting allows spin-up current almost equivalent to the pristine CNT case, resulting in lower MR. High spin filtration is observed in PC and APC for pristine, stretched and twisted structures at all applied voltages. In APC, at low voltages spin filtration in stretched CNT is higher than in pristine and twisted ones, with pristine giving a higher spin filtration than twisted CNT.

  16. A Valence-Bond Nonequilibrium Solvation Model for a Twisting Cyanine Dye

    CERN Document Server

    McConnell, Sean; Olsen, Seth

    2014-01-01

    We study a two-state valence-bond electronic Hamiltonian model of non-equilibrium solvation during the excited-state twisting reaction of monomethine cyanines. These dyes are of interest because of the strong environment-dependent enhancement of their fluorescence quantum yield that results from suppression of competing non-radiative decay via twisted internal charge-transfer (TICT) states. For monomethine cyanines, where the ground state is a superposition of structures with different bond and charge localization, there are two twisting pathways with different charge localization in the excited state. The Hamiltonian designed to be as simple as possible consistent with a few well-enumerated assumptions. It is defined by three parameters and is a function of two $\\pi$-bond twisting angle coordinates and a single solvation coordinate. For parameters corresponding to symmetric monomethines, there are two low-energy twisting channels on the excited-state surface that lead to a manifold of twisted intramolecular ...

  17. Crystal Structure of Dengue Type 1 Envelope Protein in the Postfusion Conformation and its Implication for Receptor Binding, Membrane Fusion and Antibody Recognition

    Energy Technology Data Exchange (ETDEWEB)

    Nayak, V.; Dessau, M; Kucera, K; Anthony, K; Ledizet, M; Modis, Y

    2009-01-01

    Dengue virus relies on a conformational change in its envelope protein, E, to fuse the viral lipid membrane with the endosomal membrane and thereby deliver the viral genome into the cytosol. We have determined the crystal structure of a soluble fragment E (sE) of dengue virus type 1 (DEN-1). The protein is in the postfusion conformation even though it was not exposed to a lipid membrane or detergent. At the domain I-domain III interface, 4 polar residues form a tight cluster that is absent in other flaviviral postfusion structures. Two of these residues, His-282 and His-317, are conserved in flaviviruses and are part of the pH sensor that triggers the fusogenic conformational change in E, at the reduced pH of the endosome. In the fusion loop, Phe-108 adopts a distinct conformation, forming additional trimer contacts and filling the bowl-shaped concavity observed at the tip of the DEN-2 sE trimer.

  18. Masonry building envelope analysis

    Science.gov (United States)

    McMullan, Phillip C.

    1993-04-01

    Over the past five years, infrared thermography has proven an effective tool to assist in required inspections on new masonry construction. However, with more thermographers providing this inspection service, establishing a standard for conducting these inspections is imperative. To attempt to standardize these inspections, it is important to understand the nature of the inspection as well as the context in which the inspection is typically conducted. The inspection focuses on evaluating masonry construction for compliance with the design specifications with regard to structural components and thermal performance of the building envelope. The thermal performance of the building includes both the thermal resistance of the material as well as infiltration/exfiltration characteristics. Given that the inspections occur in the 'field' rather than the controlled environment of a laboratory, there are numerous variables to be considered when undertaking this type of inspection. Both weather and site conditions at the time of the inspection can vary greatly. In this paper we will look at the variables encountered during recent inspections. Additionally, the author will present the standard which was employed in collecting this field data. This method is being incorporated into a new standard to be included in the revised version of 'Guidelines for Specifying and Performing Infrared Inspections' developed by the Infraspection Institute.

  19. Structure simulation in unidirectionally solidified turbine blade by dendrite envelope tracking model (Ⅱ): model validation and defects prediction

    Institute of Scientific and Technical Information of China (English)

    WANG Tong-min; SU Yan-qing; GUO Jing-jie; I. OHNAKA; H. YASUDA

    2006-01-01

    The developed model was validated by the checking of grain preferential growth orientation and the solidification experiment with low melting point alloy of Sn-21%Bi(mole fraction). It was also applied to predict the structure defects (e.g. stray grain) of unidirectionally solidified turbine blade. The results show that the developed model is reliable and has the following abilities: 1) reduce the misorientation caused by the orthogonal mesh used in simulation; 2) well reproduce the growth competition among the different-preferential-direction grains with less than 10% relative error; 3) predict the structure defect of stray grain with the accuracy over 80%; 4) optimize the grain selector to better obtain a single crystal avoiding the multigrain defect; 5) simulate the structure evolution (nucleation and growth) of the directional and single crystal turbine blade.

  20. Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc

    Science.gov (United States)

    Stettner, Eva; Jeffers, Scott Allen; Pérez-Vargas, Jimena; Pehau-Arnaudet, Gerard; Tortorici, M. Alejandra; Jestin, Jean-Luc; England, Patrick; Tischler, Nicole D.; Rey, Félix A.

    2016-01-01

    Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of hantavirus pulmonary syndrome (HPS), depending on the virus, which are associated with high case fatality rates. There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. We describe here the X-ray structures of Gc from Hantaan virus, the type species hantavirus and responsible for HFRS, both in its neutral pH, monomeric pre-fusion conformation, and in its acidic pH, trimeric post-fusion form. The structures confirm the prediction that Gc is a class II fusion protein, containing the characteristic β-sheet rich domains termed I, II and III as initially identified in the fusion proteins of arboviruses such as alpha- and flaviviruses. The structures also show a number of features of Gc that are distinct from arbovirus class II proteins. In particular, hantavirus Gc inserts residues from three different loops into the target membrane to drive fusion, as confirmed functionally by structure-guided mutagenesis on the HPS-inducing Andes virus, instead of having a single “fusion loop”. We further show that the membrane interacting region of Gc becomes structured only at acidic pH via a set of polar and electrostatic interactions. Furthermore, the structure reveals that hantavirus Gc has an additional N-terminal “tail” that is crucial in stabilizing the post-fusion trimer, accompanying the swapping of domain III in the quaternary arrangement of the trimer as compared to the standard class II fusion proteins. The mechanistic understandings derived from these data are likely to provide a unique handle for devising treatments against these human pathogens. PMID:27783711

  1. Functional dissection of nuclear envelope mRNA translocation system: effects of phorbol ester and a monoclonal antibody recognizing cytoskeletal structures.

    Science.gov (United States)

    Schröder, H C; Diehl-Seifert, B; Rottmann, M; Messer, R; Bryson, B A; Agutter, P S; Müller, W E

    1988-03-01

    Unidirectional transport of poly(A)-containing mRNA [poly(A)+ mRNA] through the nuclear envelope pore complex is thought to be an energy (ATP or GTP)-dependent process which involves a nuclear envelope nucleoside triphosphatase (NTPase). In the intact envelope, this enzyme is regulatable by poly(A) binding and by poly(A)-dependent phosphorylation/dephosphorylation of other components of the mRNA translocation system, which are as yet unidentified. Monoclonal antibodies (mAbs) were elicited against the poly(A) binding nuclear envelope fraction isolated from rat liver. The mAbs were screened for their modulatory effects on mRNA transport in vitro. One stable clone decreased the efflux of rapidly labeled RNA and of one specific mRNA (ovalbumin) from isolated nuclei. It increased the binding of poly(A) to the envelope and increased the maximal catalytic rate of the NTPase, but it did not alter the apparent Km of the enzyme or the extent of its stimulation by poly(A). The nuclear envelope-associated protein kinase that down-regulates the NTPase was inhibited by the antibody, while other protein kinases were not affected. Because both the NTPase and mRNA efflux were inhibited by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, the sensitive kinase is probably protein kinase C. Protein kinase C was found to be associated with the isolated nuclear envelope. The antibody reacted with both a Mr 83,000 and a Mr 65,000 nuclear envelope polypeptide from rat liver and other tissues. By immunofluorescence microscopy in CV-1 cells, the antibody localized to the nuclear envelope and, in addition, to cytoplasmic filaments which show some superposition with the microfilament network.

  2. Adaptive dual-layer super-twisting control and observation

    Science.gov (United States)

    Edwards, Christopher; Shtessel, Yuri

    2016-09-01

    In this paper, a super-twisting-like structure with adaptive gains is proposed. The structure is parameterised by two scalar gains, both of which adapt, and by an additional time-varying term. The magnitudes of the adaptive terms are allowed to both increase and decrease as appropriate so that they are as small as possible, in the sense that they do not unnecessarily over-bound the uncertainty, and yet are large enough to sustain a sliding motion. In the paper, a new time varying gain is incorporated into the traditional super-twisting architecture. The proposed adaption law has a dual-layer structure which is formally analyzed using Lyapunov techniques. The additional term has the effect of simplifying the stability analysis whilst guaranteeing the second-order sliding mode properties of the traditional super-twisting scheme.

  3. Using Pretwist to Reduce Power Loss of Bend-Twist Coupled Blades

    DEFF Research Database (Denmark)

    Stäblein, Alexander; Tibaldi, Carlo; Hansen, Morten Hartvig

    2016-01-01

    Bend-twist coupling of wind turbine blades is known as a means to reduce the structural loads of the turbine. While the load reduction is desirable, bend-twist coupling also leads to a decrease in the annual energy production of the turbine. The reduction is mainly related to a no longer optimal...... twist distribution along the blade due to the coupling induced twist. Some of the power loss can be compensated by pretwisting the blade. This paper presents a pretwisting procedure for large blade deflections and investigates the effect of pretwisting on blade geometry, annual energy production...

  4. Higher-twist mechanism and inclusive gluon production in pion-proton collisions

    Science.gov (United States)

    Ahmadov, A. I.; Aydin, C.; Myrzakulov, R.; Uzun, O.

    2015-12-01

    We calculate the contribution of the higher-twist Feynman diagrams to the large-pT inclusive gluon production cross-section in πp collisions in case of the running coupling and frozen coupling approaches within perturbative and holographic QCD. The structure of infrared renormalon singularities of the higher-twist subprocess cross-section is obtained and the resummed higher-twist cross-sections (Borel sum) with the ones obtained in the framework of the frozen coupling approach and leading-twist cross-section are compared and analyzed.

  5. Extension-twist coupling optimization in composite rotor blades

    Science.gov (United States)

    Ozbay, Serkan

    2005-07-01

    For optimal rotor performance in a tiltrotor aircraft the difference in the inflow and the rotor speeds between the hover and cruise flight modes suggests different blade twist and chord distributions. The blade twist rates in current tiltrotor applications are defined based upon a compromise between the figure of merit in hover and propeller efficiency in airplane mode. However, when each operation mode is considered separately the optimum blade distributions are found to be considerably different. Passive blade twist control, which uses the inherent variation in centrifugal forces on a rotor blade to achieve optimum blade twist distributions in each flight mode through the use of extension-twist coupled composite rotor blades, has been considered for performance improvement of tiltrotor aircraft over the last two decades. The challenge for this concept is to achieve the desired twisting deformations in the rotor blade without altering the aeroelastic characteristics of the vehicle. A concept referred to as the sliding mass concept is proposed in this work in order to increase the twist change with rotor speed for a closed-cell composite rotor blade cross-section to practical levels for performance improvement in a tiltrotor aircraft. The concept is based on load path changes for the centrifugal forces by utilizing non-structural masses readily available on a conventional blade, such as the leading edge balancing mass. A multilevel optimization technique based on the simulated annealing method is applied to improve the performance of the XV15 tiltrotor aircraft. A cross-sectional analysis tool, VABS together with a multibody dynamics code, DYMORE are integrated into the optimization process. The optimization results revealed significant improvements in the power requirement in hover while preserving cruise efficiency. It is also shown that about 21% of the improvement is provided through the sliding mass concept pointing to the additional flexibility the concept

  6. Recent Advances on the Use of Structural Biology for the Design of Novel Envelope Immunogens of HIV-1

    OpenAIRE

    Xiang, Shi-Hua

    2013-01-01

    Many efforts have been made in the worldwide quest for a prophylactic HIV vaccine to end the AIDS pandemic, but none has yet succeeded. The lessons learned have repeatedly informed us that the traditional or conventional approaches directly using the pathogens or subunits will not be sufficient for an effective HIV/AIDS vaccine. Recent advances in structure-based technology have shown some promise in the quest for a better immunogen in HIV vaccine development. According to the basic binding s...

  7. Effect of Accelerated Xenon Lamp Aging on the Mechanical Properties and Structure of Thermoplastic Polyurethane for Stratospheric Airship Envelope

    Institute of Scientific and Technical Information of China (English)

    LIU Yuyan; LIU Yuxi; LIU Shaozhu; TAN Huifeng

    2014-01-01

    This study aimed to investigate the effect of artificial weathering test on the photoaging behavior of TPU films. Changes in mechanical properties, morphology and chemical structures are studied by tensile test, scanning electron microscopy, atomic force microscopy, Fourier-transformed infrared, and X-ray photoelectron spectroscopy. The results show that the photoaging negatively affects the initial modulus and stress at break values of TPU films. The surface of the specimen that is exposed to irradiation becomes rough, and some visible micro-defects such as blisters and voids can be detected. The morphology of the fracture surfaces illustrates that irradiation reduces the plasticity but increases the brittleness of the TPU films. The chemical structure analyses of the accelerated aged films prove that chemical structural changes in TPU films occur. The irradiation may break the long molecular chains on the surface of the specimens and form the low-molecular weight oxygen-containing groups. The number of chain scissions increases with the increase in exposure time.

  8. Polarization twist in perovskite ferrielectrics.

    Science.gov (United States)

    Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro

    2016-09-02

    Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of 'polarization twist', which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms.

  9. Enveloped and non-enveloped viral-like particles in Trypanosoma cruzi epimastigotes

    Science.gov (United States)

    Fernández-Presas, Ana María; Padilla-Noriega, Luis; Ingeborg-Becker; Robert, Lilia; Jiménez, José Agustín; Solano, Sandra; Delgado, Jose; Tato, Patricia; Molinari, José Luis

    2017-01-01

    ABSTRACT Electron microscopy is routinely used to identify viral infections in protozoan parasites. These viruses have been described as non-enveloped and icosahedral structures with a diameter of 30-60 nm. Most of them are classified within the non-segmented dsRNA Totiviridae family. We observed virus-like particles (VLPs) through transmission electron microscopy in the cytoplasm of Trypanosoma cruzi epimastigotes grown in cultures. Clusters of electrodense enveloped VLPs having a diameter of 48 nm were also observed. These clusters appear to have been released from distended Golgi cisternae. Furthermore, a paracrystalline array of electrodense, non-enveloped VLPs (with a diameter of 32 nm) were found in distended Golgi cisternae or as smaller clusters at a distance from the RE or Golgi. We cannot rule out that the 48 nm enveloped VLPs belong to the ssRNA Flaviviridae family because they are within its size range. The localization of enveloped VLPs is consistent with the replication strategy of these viruses that transit through the Golgi to be released at the cell surface. Due to the size and shape of the 32 nm non-enveloped VLPs, we propose that they belong to the dsRNA Totiviridae family. This is the first description of cytoplasmic enveloped and non-enveloped VLPs in T. cruzi epimastigotes. PMID:28793017

  10. Evidence that F-plasmid proteins TraV, TraK and TraB assemble into an envelope-spanning structure in Escherichia coli.

    Science.gov (United States)

    Harris, R L; Hombs, V; Silverman, P M

    2001-11-01

    We have examined the role of the F-plasmid TraV outer membrane lipoprotein in the assembly of F-pili. Yeast two-hybrid analysis with a traV bait repeatedly identified traK, which is predicted to encode a periplasmic protein, among positive prey plasmids. A traK bait in turn identified traV and traB, which is predicted to encode an inner membrane protein. A traB bait exclusively identified traK preys. Several additional observations support the hypothesis that TraV, TraK and TraB form a complex in Escherichia coli that spans the cell envelope from the outer membrane (TraV) through the periplasm (TraK) to the inner membrane (TraB). First, two-hybrid analyses indicated that TraV and TraB bind to different TraK segments, as required if TraK bridges a ternary complex. Secondly, all three proteins fractionated with the E. coli outer membrane in tra+ cells. In contrast, TraB fractionated with the inner membrane in traV or traK mutant cells, and TraK appeared in the osmotic shock fluid from the traV mutant. These results are consistent with a TraV-TraK-TraB complex anchored to the outer membrane via the TraV lipoprotein. Further, in traK mutant cells, TraV failed to accumulate to a detectable level, and the TraB level was significantly reduced, suggesting that TraV and TraB must interact with TraK for either protein to accumulate to its normal level. Both TraK and TraV accumulated in traB2[Am] cells; however, the TraB2 amber fragment could be detected by Western blot, and sequence analysis indicated that the fragment retained the TraK-binding domain suggested by yeast two-hybrid analysis. We propose that TraV is the outer membrane anchor for a trans-envelope, Tra protein structure required for the assembly of F-pili and possibly for other events of conjugal DNA transfer.

  11. Instanton corrections to twist-two operators

    CERN Document Server

    Alday, Luis F

    2016-01-01

    We present the calculation of the leading instanton contribution to the scaling dimensions of twist-two operators with arbitrary spin and to their structure constants in the OPE of two half-BPS operators in $\\mathcal N=4$ SYM. For spin-two operators we verify that, in agreement with $\\mathcal N=4$ superconformal Ward identities, the obtained expressions coincide with those for the Konishi operator. For operators with high spin we find that the leading instanton correction vanishes. This arises as the result of a rather involved calculation and requires a better understanding.

  12. Berry phase transition in twisted bilayer graphene

    Science.gov (United States)

    Rode, Johannes C.; Smirnov, Dmitri; Schmidt, Hennrik; Haug, Rolf J.

    2016-09-01

    The electronic dispersion of a graphene bilayer is highly dependent on rotational mismatch between layers and can be further manipulated by electrical gating. This allows for an unprecedented control over electronic properties and opens up the possibility of flexible band structure engineering. Here we present novel magnetotransport data in a twisted bilayer, crossing the energetic border between decoupled monolayers and coupled bilayer. In addition a transition in Berry phase between π and 2π is observed at intermediate magnetic fields. Analysis of Fermi velocities and gate induced charge carrier densities suggests an important role of strong layer asymmetry for the observed phenomena.

  13. Bend-twist coupling potential of wind turbine blades

    DEFF Research Database (Denmark)

    Fedorov, Vladimir; Berggreen, Christian

    2014-01-01

    In the present study an evaluation of the potential for bend-twist coupling effects in wind turbine blades is addressed. A method for evaluation of the coupling magnitude based on the results of finite element modeling and full-field displacement measurements obtained by experiments is developed...... and tested on small-scale coupled composite beams. In the proposed method the coupling coefficient for a generic beam is introduced based on the Euler-Bernoulli beam formulation. By applying the developed method for analysis of a commercial wind turbine blade structure it is demonstrated that a bend......-twist coupling magnitude of up to 0.2 is feasible to achieve in the baseline blade structure made of glass-fiber reinforced plastics. Further, by substituting the glass-fibers with carbon-fibers the coupling effect can be increased to 0.4. Additionally, the effect of introduction of bend-twist coupling...

  14. Output Feedback Control of Electro-Hydraulic Cylinder Drives using the Twisting Algorithm

    DEFF Research Database (Denmark)

    Schmidt, Lasse; Andersen, Torben Ole; Pedersen, Henrik C.

    2014-01-01

    This paper discusses the utilization of the so-called twisting algorithm when applied in output feedback position control schemes for electro-hydraulic cylinder drives. The twisting controller was the first second order sliding controller ever introduced, and can structure-wise be considered a st...

  15. Exact special twist method for quantum Monte Carlo simulations

    Science.gov (United States)

    Dagrada, Mario; Karakuzu, Seher; Vildosola, Verónica Laura; Casula, Michele; Sorella, Sandro

    2016-12-01

    We present a systematic investigation of the special twist method introduced by Rajagopal et al. [Phys. Rev. B 51, 10591 (1995), 10.1103/PhysRevB.51.10591] for reducing finite-size effects in correlated calculations of periodic extended systems with Coulomb interactions and Fermi statistics. We propose a procedure for finding special twist values which, at variance with previous applications of this method, reproduce the energy of the mean-field infinite-size limit solution within an adjustable (arbitrarily small) numerical error. This choice of the special twist is shown to be the most accurate single-twist solution for curing one-body finite-size effects in correlated calculations. For these reasons we dubbed our procedure "exact special twist" (EST). EST only needs a fully converged independent-particles or mean-field calculation within the primitive cell and a simple fit to find the special twist along a specific direction in the Brillouin zone. We first assess the performances of EST in a simple correlated model such as the three-dimensional electron gas. Afterwards, we test its efficiency within ab initio quantum Monte Carlo simulations of metallic elements of increasing complexity. We show that EST displays an overall good performance in reducing finite-size errors comparable to the widely used twist average technique but at a much lower computational cost since it involves the evaluation of just one wave function. We also demonstrate that the EST method shows similar performances in the calculation of correlation functions, such as the ionic forces for structural relaxation and the pair radial distribution function in liquid hydrogen. Our conclusions point to the usefulness of EST for correlated supercell calculations; our method will be particularly relevant when the physical problem under consideration requires large periodic cells.

  16. The geometrical origin of the strain-twist coupling in double helices

    Directory of Open Access Journals (Sweden)

    Kasper Olsen

    2011-03-01

    Full Text Available A simple geometrical explanation for the counterintuitive phenomenon when twist leads to extension in double helices is presented. The coupling between strain and twist is investigated using a tubular description. It is shown that the relation between strain and rotation is universal and depends only on the pitch angle. For pitch angles below 39.4° strain leads to further winding, while for larger pitch angles strain leads to unwinding. The zero-twist structure, with a pitch angle of 39.4°, is at the unique point between winding and unwinding and independent of the mechanical properties of the double helix. The existence of zero-twist structures, i.e. structures that display neither winding, nor unwinding under strain is discussed. Close-packed double helices are shown to extend rather than shorten when twisted. Numerical estimates of this elongation upon winding are given for DNA, chromatin, and RNA.

  17. Fundamental aeroelastic properties of a bend–twist coupled blade section

    DEFF Research Database (Denmark)

    Stäblein, Alexander R.; Hansen, Morten Hartvig; Pirrung, Georg

    2017-01-01

    The effects of bend–twist coupling on the aeroelastic modal properties and stability limits of a two-dimensional blade section in attached flow are investigated. Bend–twist coupling is introduced in the stiffness matrix of the structural blade section model. The structural model is coupled...... with an unsteady aerodynamic model in a linearised state–space formulation. A numerical study is performed using structural and aerodynamic parameters representative for wind turbine blades. It is shown that damping of the edgewise mode is primarily influenced by the work of the lift which is close to antiphase...... to an edgetwist flutter instability at much lower inflow speeds than the uncoupled blade section. Flap–twist coupling results in a moderate reduction of the flutter speed for twist to feather and divergence for twist to stall....

  18. Occurrence and core-envelope structure of 1--4x Earth-size planets around Sun-like stars

    CERN Document Server

    Marcy, Geoffrey W; Petigura, Erik A; Isaacson, Howard; Howard, Andrew W; Buchhave, Lars A

    2014-01-01

    Small planets, 1-4x the size of Earth, are extremely common around Sun-like stars, and surprisingly so, as they are missing in our solar system. Recent detections have yielded enough information about this class of exoplanets to begin characterizing their occurrence rates, orbits, masses, densities, and internal structures. The Kepler mission finds the smallest planets to be most common, as 26% of Sun-like stars have small, 1-2 R_e planets with orbital periods under 100 days, and 11% have 1-2 R_e planets that receive 1-4x the incident stellar flux that warms our Earth. These Earth-size planets are sprinkled uniformly with orbital distance (logarithmically) out to 0.4 AU, and probably beyond. Mass measurements for 33 transiting planets of 1-4 R_e show that the smallest of them, R < 1.5 R_e, have the density expected for rocky planets. Their densities increase with increasing radius, likely caused by gravitational compression. Including solar system planets yields a relation: rho = 2.32 + 3.19 R/R_e [g/cc]. ...

  19. 假捻集聚纺假捻器位置及结构参数的优化%Optimization of gauge and structural parameters of false twister of false-twist compact spinning method

    Institute of Scientific and Technical Information of China (English)

    付江; 于伟东

    2011-01-01

    为对假捻集聚纺假捻器的作用有更深刻的认识,采用响应曲面方法分析假捻器的位置及结构参数对成纱性能的影响,并采用满意度函数方法对上述参数进行多响应优化.结果表明:纱线的条干CV值主要受假捻腔最小曲率半径的影响;假捻器转速比和假捻腔的最小曲率半径对纱线毛羽指数的影响作用比较明显;实验研究的3个参数对纱线断裂强度和断裂伸长率都有影响.满意度函数多响应优化结果显示,当假捻器转速比为0.367~0.374,假捻器隔距为11 mm,假捻腔的最小曲率半径为18.2~18.3 mm时,纱线的整体质量最好.%In order to have a clear understanding of the function of the false twister used in the false-twist compact spinning method, the response surface methodology was used to study the influences of the gauge and structural parameters of the false twister on the properties of resultant yarns. Afterwards, the optimal parameter settings were found by employing the desirability function approach. The results showed that yarn evenness was mostly affected by the minimum curvature radius of the false-twist channel, while the rotational speed ratio of false twister and minimum curvature radius have remarkable influences on yarn hairiness index. All of the three parameters under investigation have certain effects on the breaking strength and breaking elongation of yarns. The optimization result indicated that when the rotational speed ratio is 0. 367 - 0. 374, the gauge of the false twister is set as 11 mm and the minimum curvature radius of the false-twist channel is 18.2 - 18.3 mm, the resultant yams will have a relatively better quality.

  20. Properly twisted groups and their algebras

    CERN Document Server

    Bales, John W

    2011-01-01

    A twist property is developed which imparts certain properties on the twisted group algebra. These include an involution * satisfying (xy)*=y*x* and an inner product satisfying = and =. Examples of twisted group algebras having this property are the Cayley-Dickson algebras and Clifford algebras.

  1. Linac Envelope Optics

    CERN Document Server

    Baartman, Rick

    2015-01-01

    I develop the formalism that allows calculation of beam envelopes through a linear accelerator given its on-axis electric field. Space charge can naturally be added using Sacherer formalism. A complicating feature is that the reference particle's energy-time coordinates are not known a priori. Since first order matrix formalism applies to deviations from the reference particle, this means the reference particle's time and energy must be calculated simultaneously with the beam envelope and transfer matrix. The code TRANSOPTR is used to track envelopes for general elements whose infinitesimal transfer matrices are known, and in the presence of space charge. Incorporation of the linac algorithm into TRANSOPTR is described, and some examples given.

  2. Three-dimensional structure of the enveloped bacteriophage phi12: an incomplete T = 13 lattice is superposed on an enclosed T = 1 shell.

    Directory of Open Access Journals (Sweden)

    Hui Wei

    Full Text Available BACKGROUND: Bacteriophage phi12 is a member of the Cystoviridae, a unique group of lipid containing membrane enveloped bacteriophages that infect the bacterial plant pathogen Pseudomonas syringae pv. phaseolicola. The genomes of the virus species contain three double-stranded (dsRNA segments, and the virus capsid itself is organized in multiple protein shells. The segmented dsRNA genome, the multi-layered arrangement of the capsid and the overall viral replication scheme make the Cystoviridae similar to the Reoviridae. METHODOLOGY/PRINCIPAL FINDINGS: We present structural studies of cystovirus phi12 obtained using cryo-electron microscopy and image processing techniques. We have collected images of isolated phi12 virions and generated reconstructions of both the entire particles and the polymerase complex (PC. We find that in the nucleocapsid (NC, the phi12 P8 protein is organized on an incomplete T = 13 icosahedral lattice where the symmetry axes of the T = 13 layer and the enclosed T = 1 layer of the PC superpose. This is the same general protein-component organization found in phi6 NC's but the detailed structure of the entire phi12 P8 layer is distinct from that found in the best classified cystovirus species phi6. In the reconstruction of the NC, the P8 layer includes protein density surrounding the hexamers of P4 that sit at the 5-fold vertices of the icosahedral lattice. We believe these novel features correspond to dimers of protein P7. CONCLUSIONS/SIGNIFICANCE: In conclusion, we have determined that the phi12 NC surface is composed of an incomplete T = 13 P8 layer forming a net-like configuration. The significance of this finding in regard to cystovirus assembly is that vacancies in the lattice could have the potential to accommodate additional viral proteins that are required for RNA packaging and synthesis.

  3. "Oliver Twist": A Teacher's Guide.

    Science.gov (United States)

    Cashion, Carol; Fischer, Diana

    This teacher's guide for public television's 3-part adaptation of Charles Dickens's "Oliver Twist" provides information that will help enrich students' viewing of the series, whether or not they read the novel. The guide includes a wide range of discussion and activity ideas; there is also a series Web site and a list of Web resources.…

  4. Helically twisted photonic crystal fibres.

    Science.gov (United States)

    Russell, P St J; Beravat, R; Wong, G K L

    2017-02-28

    Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic 'space', cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of 'numerical experiments' based on finite-element solutions of Maxwell's equations in a helicoidal frame.This article is part of the themed issue 'Optical orbital angular momentum'. © 2017 The Authors.

  5. Helically twisted photonic crystal fibres

    Science.gov (United States)

    Russell, P. St. J.; Beravat, R.; Wong, G. K. L.

    2017-02-01

    Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic `space', cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of `numerical experiments' based on finite-element solutions of Maxwell's equations in a helicoidal frame. This article is part of the themed issue 'Optical orbital angular momentum'.

  6. Helically twisted photonic crystal fibres

    Science.gov (United States)

    Beravat, R.; Wong, G. K. L.

    2017-01-01

    Recent theoretical and experimental work on helically twisted photonic crystal fibres (PCFs) is reviewed. Helical Bloch theory is introduced, including a new formalism based on the tight-binding approximation. It is used to explore and explain a variety of unusual effects that appear in a range of different twisted PCFs, including fibres with a single core and fibres with N cores arranged in a ring around the fibre axis. We discuss a new kind of birefringence that causes the propagation constants of left- and right-spinning optical vortices to be non-degenerate for the same order of orbital angular momentum (OAM). Topological effects, arising from the twisted periodic ‘space’, cause light to spiral around the fibre axis, with fascinating consequences, including the appearance of dips in the transmission spectrum and low loss guidance in coreless PCF. Discussing twisted fibres with a single off-axis core, we report that optical activity in a PCF is opposite in sign to that seen in a step-index fibre. Fabrication techniques are briefly described and emerging applications reviewed. The analytical results of helical Bloch theory are verified by an extensive series of ‘numerical experiments’ based on finite-element solutions of Maxwell's equations in a helicoidal frame. This article is part of the themed issue ‘Optical orbital angular momentum’. PMID:28069771

  7. The trouble with twisting (2,0) theory

    CERN Document Server

    Anderson, Louise

    2013-01-01

    We consider a twisted version of the abelian (2,0) theory placed upon a Lorenzian six-manifold with a product structure, $M_6=C \\times M_4 $. This is done by an investigation of the free tensor multiplet on the level of equations of motion, where the problem of its formulation in Euclidean signature is circumvented by letting the time-like direction lie in the two-manifold $C$ and performing a topological twist along $M_4$ alone. A compactification on $C$ is shown to be necessary to enable the possibility of finding a topological field theory. The hypothetical twist along a Euclidean $C$ is argued to amount to the correct choice of linear combination of the two supercharges scalar on $M_4$. It may be slightly surprising that this is not the same linear combination as in the well known Donaldson-Witten twist. A more surprising fact however, is that this twisted theory contains no $Q$-exact and covariantly conserved stress tensor unless $M_4$ has vanishing curvature. This is to our knowledge a phenomenon which ...

  8. The trouble with twisting (2,0) theory

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Louise; Linander, Hampus [Department of Fundamental Physics, Chalmers University of Technology,S-412 96 Göteborg (Sweden)

    2014-03-12

    We consider a twisted version of the abelian (2,0) theory placed upon a Lorentzian six-manifold with a product structure, M{sub 6}=C×M{sub 4}. This is done by an investigation of the free tensor multiplet on the level of equations of motion, where the problem of its formulation in Euclidean signature is circumvented by letting the time-like direction lie in the two-manifold C and performing a topological twist along M{sub 4} alone. A compactification on C is shown to be necessary to enable the possibility of finding a topological field theory. The hypothetical twist along a Euclidean C is argued to amount to the correct choice of linear combination of the two supercharges scalar on M{sub 4}. This procedure is expected and conjectured to result in a topological field theory, but we arrive at the surprising conclusion that this twisted theory contains no Q-exact and covariantly conserved stress tensor unless M{sub 4} has vanishing curvature. This is to our knowledge a phenomenon which has not been observed before in topological field theories. In the literature, the setup of the twisting used here has been suggested as the origin of the conjectured AGT-correspondence, and our hope is that this work may somehow contribute to the understanding of it.

  9. Higher twist effects in deeply virtual Compton scattering

    Energy Technology Data Exchange (ETDEWEB)

    Pirnay, Bjoern Michael

    2016-08-01

    In this work we explore the effects of higher twist power corrections on the deeply virtual Compton scattering process. The calculation of the helicity amplitudes for all possible polarization combinations is performed within the framework of QCD operator product expansion. As a result the known accuracy of the amplitudes is improved to include the (kinematic) twist-4 contributions. For the most part the analysis focuses on spin-1/2 targets, the answers for scalar targets conveniently emerge as a byproduct. We investigate the analytical structure of these corrections and prove consistency with QCD factorization. We give an estimation of the numerical impact of the sub-leading twist contributions for proton targets with the help of a phenomenological model for the nonperturbative proton generalized parton distributions. We compare different twist approximations and relate predictions for physical observables to experiments performed by the Hall A, CLAS, HERMES, H1 and ZEUS collaborations. The estimate also includes a numerical study for planned COMPASS-II runs. Throughout the analysis special emphasis is put on the convention dependence induced by finite twist truncation of scattering amplitudes.

  10. "Twisted Beam" SEE Observations of Ionospheric Heating from HAARP

    Science.gov (United States)

    Briczinski, S. J.; Bernhardt, P. A.; Siefring, C. L.; Han, S.-M.; Pedersen, T. R.; Scales, W. A.

    2015-10-01

    Nonlinear interactions of high power HF radio waves in the ionosphere provide aeronomers with a unique space-based laboratory capability. The High-Frequency Active Auroral Research Program (HAARP) in Gakona, Alaska is the world's largest heating facility, yielding effective radiated powers in the gigawatt range. New results are present from HAARP experiments using a "twisted beam" excitation mode. Analysis of twisted beam heating shows that the SEE results obtained are identical to more traditional patterns. One difference in the twisted beam mode is the heating region produced is in the shape of a ring as opposed to the more traditional "solid spot" region from a pencil beam. The ring heating pattern may be more conducive to the creation of stable artificial airglow layers because of the horizontal structure of the ring. The results of these runs include artificial layer creation and evolution as pertaining to the twisted beam pattern. The SEE measurements aid the interpretation of the twisted beam interactions in the ionosphere.

  11. Curvature regulation of the ciliary beat through axonemal twist

    Science.gov (United States)

    Sartori, Pablo; Geyer, Veikko F.; Howard, Jonathon; Jülicher, Frank

    2016-10-01

    Cilia and flagella are hairlike organelles that propel cells through fluid. The active motion of the axoneme, the motile structure inside cilia and flagella, is powered by molecular motors of the axonemal dynein family. These motors generate forces and torques that slide and bend the microtubule doublets within the axoneme. To create regular waveforms, the activities of the dyneins must be coordinated. It is thought that coordination is mediated by stresses due to radial, transverse, or sliding deformations, and which build up within the moving axoneme and feed back on dynein activity. However, which particular components of the stress regulate the motors to produce the observed waveforms of the many different types of flagella remains an open question. To address this question, we describe the axoneme as a three-dimensional bundle of filaments and characterize its mechanics. We show that regulation of the motors by radial and transverse stresses can lead to a coordinated flagellar motion only in the presence of twist. We show that twist, which could arise from torque produced by the dyneins, couples curvature to transverse and radial stresses. We calculate emergent beating patterns in twisted axonemes resulting from regulation by transverse stresses. The resulting waveforms are similar to those observed in flagella of Chlamydomonas and sperm. Due to the twist, the waveform has nonplanar components, which result in swimming trajectories such as twisted ribbons and helices, which agree with observations.

  12. Quasistars: Accreting black holes inside massive envelopes

    CERN Document Server

    Begelman, Mitchell C; Armitage, Philip J

    2007-01-01

    We study the structure and evolution of "quasistars," accreting black holes embedded within massive hydrostatic gaseous envelopes. These configurations may model the early growth of supermassive black hole seeds. The accretion rate onto the black hole adjusts so that the luminosity carried by the convective envelope equals the Eddington limit for the total mass. This greatly exceeds the Eddington limit for the black hole mass alone, leading to rapid growth of the black hole. We use analytic models and numerical stellar structure calculations to study the structure and evolution of quasistars. We derive analytically the scaling of the photospheric temperature with the black hole mass and envelope mass, and show that it decreases with time as the black hole mass increases. Once the photospheric temperature becomes lower than 10000 K, the photospheric opacity drops precipitously and the photospheric temperature hits a limiting value, analogous to the Hayashi track for red giants and protostars, below which no hy...

  13. Flexible Envelope Request Notation (FERN)

    Science.gov (United States)

    Zoch, David R.; Lavallee, David; Weinstein, Stuart

    1991-01-01

    The following topics are presented in view graph form and include the following: scheduling application; the motivation for the Flexible Envelope Request Notation (FERN); characteristics of FERN; types of information needed in requests; where information is stored in requests; FERN structures; generic requests; resource availability for pooled resources; expressive notation; temporal constraints; time formats; changes to FERN; sample FERN requests; the temporal relationship between two steps; maximum activity length to limit step delays; alternative requests; the temporal relationship between two activities; and idle resource usage between steps.

  14. Twists of Pl\\"ucker coordinates as dimer partition functions

    CERN Document Server

    Scott, Jeanne

    2013-01-01

    The homogeneous coordinate ring of the Grassmannian Gr(k,n) has a cluster structure defined in terms of planar diagrams known as Postnikov diagrams. The cluster corresponding to such a diagram consists entirely of Pl\\"ucker coordinates. We introduce a twist map on Gr(k,n) related to the BZ-twist, and give an explicit Laurent expansion for the twist of an arbitrary Pl\\"ucker coordinate, in terms of the cluster variables associated with a fixed Postnikov diagram. The expansion arises as a (scaled) dimer partition function of a weighted version of the bipartite graph dual to the Postnikov diagram, modified by a boundary condition determined by the Pl\\"ucker coordinate.

  15. Twisting Fluorescence through Extrinsic Chiral Antennas.

    Science.gov (United States)

    Yan, Chen; Wang, Xiaolong; Raziman, T V; Martin, Olivier J F

    2017-03-22

    Plasmonic antennas and planar structures have been undergoing intensive developments in order to control the scattering and absorption of light. One specific class, extrinsic chiral surfaces, that does not possess 2-fold rotational symmetry exhibits strong asymmetric transmission for different circular polarizations under obliquely incident illumination. In this work, we show that the design of those surfaces can be optimized with complex multipolar resonances in order to twist the fluorescence emission from nearby molecules. While this emission is usually dipolar and linearly polarized, the interaction with these resonances twists it into a multipolar radiation pattern with opposite helicity in different directions. The proposed structure maximizes this effect and provides control over the polarization of light. Splitting of left- and right-handed circularly polarized light is experimentally obtained in the backward direction. These results highlight the intricate interplay between the near-field absorption and the far-field scattering of a plasmonic nanostructure and are further used for modifying the emission of incoherent quantum sources. Our finding can potentially lead to the development of polarization- and angle-resolved ultracompact optical devices.

  16. HIV-1 envelope glycoprotein

    Energy Technology Data Exchange (ETDEWEB)

    Caulfield, Michael; Cupo, Albert; Dean, Hansi; Hoffenberg, Simon; King, C. Richter; Klasse, P. J.; Marozsan, Andre; Moore, John P.; Sanders, Rogier W.; Ward, Andrew; Wilson, Ian; Julien, Jean-Philippe

    2017-08-22

    The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

  17. Explicit formulae for Chern-Simons invariants of the twist-knot orbifolds and edge polynomials of twist knots

    Science.gov (United States)

    Ham, J.-Y.; Lee, J.

    2016-09-01

    We calculate the Chern-Simons invariants of twist-knot orbifolds using the Schläfli formula for the generalized Chern-Simons function on the family of twist knot cone-manifold structures. Following the general instruction of Hilden, Lozano, and Montesinos-Amilibia, we here present concrete formulae and calculations. We use the Pythagorean Theorem, which was used by Ham, Mednykh and Petrov, to relate the complex length of the longitude and the complex distance between the two axes fixed by two generators. As an application, we calculate the Chern-Simons invariants of cyclic coverings of the hyperbolic twist-knot orbifolds. We also derive some interesting results. The explicit formulae of the A-polynomials of twist knots are obtained from the complex distance polynomials. Hence the edge polynomials corresponding to the edges of the Newton polygons of the A-polynomials of twist knots can be obtained. In particular, the number of boundary components of every incompressible surface corresponding to slope -4n+2 turns out to be 2. Bibliography: 39 titles.

  18. Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate.

    Science.gov (United States)

    Langevin, Stanley A; Bowen, Richard A; Ramey, Wanichaya N; Sanders, Todd A; Maharaj, Payal D; Fang, Ying; Cornelius, Jennine; Barker, Christopher M; Reisen, William K; Beasley, David W C; Barrett, Alan D T; Kinney, Richard M; Huang, Claire Y-H; Brault, Aaron C

    2011-12-01

    The hallmark attribute of North American West Nile virus (WNV) strains has been high pathogenicity in certain bird species. Surprisingly, this avian virulent WNV phenotype has not been observed during its geographical expansion into the Caribbean, Central America and South America. One WNV variant (TM171-03-pp1) isolated in Mexico has demonstrated an attenuated phenotype in two widely distributed North American bird species, American crows (AMCRs) and house sparrows (HOSPs). In order to identify genetic determinants associated with attenuated avian replication of the TM171-03-pp1 variant, chimeric viruses between the NY99 and Mexican strains were generated, and their replicative capacity was assessed in cell culture and in AMCR, HOSP and house finch avian hosts. The results demonstrated that mutations in both the pre-membrane (prM-I141T) and envelope (E-S156P) genes mediated the attenuation phenotype of the WNV TM171-03-pp1 variant in a chicken macrophage cell line and in all three avian species assayed. Inclusion of the prM-I141T and E-S156P TM171-03-pp1 mutations in the NY99 backbone was necessary to achieve the avian attenuation level of the Mexican virus. Furthermore, reciprocal incorporation of both prM-T141I and E-P156S substitutions into the Mexican virus genome was necessary to generate a virus that exhibited avian virulence equivalent to the NY99 virus. These structural changes may indicate the presence of new evolutionary pressures exerted on WNV populations circulating in Latin America or may signify a genetic bottleneck that has constrained their epiornitic potential in alternative geographical locations.

  19. Action of the cork twist on Floer homology

    CERN Document Server

    Akbulut, Selman

    2011-01-01

    We utilize the Ozsvath-Szabo contact invariant to detect the action of involutions on certain homology spheres that are surgeries on symmetric links, generalizing a previous result of Akbulut and Durusoy. Potentially this may be useful to detect different smooth structures on 4-manifolds by cork twisting operation.

  20. The geometrical origin of the strain-twist coupling in double helices

    DEFF Research Database (Denmark)

    Olsen, Kasper; Bohr, Jakob

    2011-01-01

    only on the pitch angle. For pitch angles below 39.4◦ strain leads to further winding, while for larger pitch angles strain leads to unwinding. The zero-twist structure, with a pitch angle of 39.4◦, is at the unique point between winding and unwinding and independent of the mechanical properties...... of the double helix. The existence of zero-twist structures, i.e. structures that display neither winding, nor unwinding under strain is discussed. Close-packed double helices are shown to extend rather than shorten when twisted. Numerical estimates of this elongation upon winding are given for DNA, chromatin...

  1. Renormalization constants for 2-twist operators in twisted mass QCD

    CERN Document Server

    Alexandrou, C; Korzec, T; Panagopoulos, H; Stylianou, F

    2010-01-01

    Perturbative and non-perturbative results on the renormalization constants of the fermion field and the twist-2 fermion bilinears are presented with emphasis on the non-perturbative evaluation of the one-derivative twist-2 vector and axial vector operators. Non-perturbative results are obtained using the twisted mass Wilson fermion formulation employing two degenerate dynamical quarks and the tree-level Symanzik improved gluon action. The simulations have been performed for pion masses in the range of about 450-260 MeV and at three values of the lattice spacing $a$ corresponding to $\\beta=3.9, 4.05, 4.20$. Subtraction of ${\\cal O}(a^2)$ terms is carried out by performing the perturbative evaluation of these operators at 1-loop and up to ${\\cal O}(a^2)$. The renormalization conditions are defined in the RI$'$-MOM scheme, for both perturbative and non-perturbative results. The renormalization factors, obtained for different values of the renormalization scale, are evolved perturbatively to a reference scale set...

  2. Twisted molecular magnets

    DEFF Research Database (Denmark)

    Inglis, Ross; Milios, Constantinos J.; Jones, Leigh F.

    2012-01-01

    The use of derivatised salicylaldoximes in manganese chemistry has led to the synthesis of a family of approximately fifty hexanuclear ([Mn(III)(6)]) and thirty trinuclear ([Mn(III)(3)]) Single-Molecule Magnets (SMMs). Deliberate, targeted structural distortion of the metallic core afforded family...

  3. "Twisted" black holes are unphysical

    CERN Document Server

    Gray, Finnian; Schuster, Sebastian; Visser, Matt

    2016-01-01

    So-called "twisted" black holes have recently been proposed by Zhang (1609.09721 [gr-qc]), and further considered by Chen and Jing (1610.00886 [gr-qc]), and more recently by Ong (1610.05757 [gr-qc]). While these spacetimes are certainly Ricci-flat, and so mathematically satisfy the vacuum Einstein equations, they are also merely minor variants on Taub--NUT spacetimes. Consequently they exhibit several unphysical features that make them quite unreasonable as realistic astrophysical objects. Specifically, these "twisted" black holes are not (globally) asymptotically flat. Furthermore, they contain closed timelike curves that are not hidden behind any event horizon --- the most obvious of these closed timelike curves are small azimuthal circles around the rotation axis, but the effect is more general. The entire region outside the horizon is infested with closed timelike curves.

  4. Polarization twist in perovskite ferrielectrics

    Science.gov (United States)

    Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro

    2016-01-01

    Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of ‘polarization twist’, which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms. PMID:27586824

  5. Polarization twist in perovskite ferrielectrics

    Science.gov (United States)

    Kitanaka, Yuuki; Hirano, Kiyotaka; Ogino, Motohiro; Noguchi, Yuji; Miyayama, Masaru; Moriyoshi, Chikako; Kuroiwa, Yoshihiro

    2016-09-01

    Because the functions of polar materials are governed primarily by their polarization response to external stimuli, the majority of studies have focused on controlling polar lattice distortions. In some perovskite oxides, polar distortions coexist with nonpolar tilts and rotations of oxygen octahedra. The interplay between nonpolar and polar instabilities appears to play a crucial role, raising the question of how to design materials by exploiting their coupling. Here, we introduce the concept of ‘polarization twist’, which offers enhanced control over piezoelectric responses in polar materials. Our experimental and theoretical studies provide direct evidence that a ferrielectric perovskite exhibits a large piezoelectric response because of extended polar distortion, accompanied by nonpolar octahedral rotations, as if twisted polarization relaxes under electric fields. The concept underlying the polarization twist opens new possibilities for developing alternative materials in bulk and thin-film forms.

  6. Needleless electrospinning with twisted wire spinneret.

    Science.gov (United States)

    Holopainen, Jani; Penttinen, Toni; Santala, Eero; Ritala, Mikko

    2015-01-16

    A needleless electrospinning setup named 'Needleless Twisted Wire Electrospinning' was developed. The polymer solution is electrospun from the surface of a twisted wire set to a high voltage and collected on a cylindrical collector around the wire. Multiple Taylor cones are simultaneously self-formed on the downward flowing solution. The system is robust and simple with no moving parts aside from the syringe pump used to transport the solution to the top of the wire. The structure and process parameters of the setup and the results on the preparation of polyvinyl pyrrolidone (PVP), hydroxyapatite (HA) and bioglass fibers with the setup are presented. PVP fiber sheets with areas of 40 × 120 cm(2) and masses up to 1.15 g were prepared. High production rates of 5.23 g h(-1) and 1.40 g h(-1) were achieved for PVP and HA respectively. The major limiting factor of the setup is drying of the polymer solution on the wire during the electrospinning process which will eventually force to interrupt the process for cleaning of the wire. Possible solutions to this problem and other ways to develop the setup are discussed. The presented system provides a simple way to increase the production rate and area of fiber sheet as compared with the conventional needle electrospinning.

  7. Holographic generation of highly twisted electron beams

    CERN Document Server

    Grillo, Vincenzo; Mafakheri, Erfan; Frabboni, Stefano; Karimi, Ebrahim; Boyd, Robert W

    2014-01-01

    Free electrons can possess an intrinsic orbital angular momentum, similar to those in an electron cloud, upon free-space propagation. The wavefront corresponding to the electron's wavefunction forms a helical structure with a number of twists given by the \\emph{angular speed}. Beams with a high number of twists are of particular interest because they carry a high magnetic moment about the propagation axis. Among several different techniques, electron holography seems to be a promising approach to shape a \\emph{conventional} electron beam into a helical form with large values of angular momentum. Here, we propose and manufacture a nano-fabricated phase hologram for generating a beam of this kind with an orbital angular momentum up to 200$\\hbar$. Based on a novel technique the value of orbital angular momentum of the generated beam are measured, then compared with simulations. Our work, apart from the technological achievements, may lead to a way of generating electron beams with a high quanta of magnetic momen...

  8. Twisted geometries, twistors and conformal transformations

    CERN Document Server

    Långvik, Miklos

    2016-01-01

    The twisted geometries of spin network states are described by simple twistors, isomorphic to null twistors with a time-like direction singled out. The isomorphism depends on the Immirzi parameter, and reduces to the identity when the parameter goes to infinity. Using this twistorial representation we study the action of the conformal group SU(2,2) on the classical phase space of loop quantum gravity, described by twisted geometry. The generators of translations and conformal boosts do not preserve the geometric structure, whereas the dilatation generator does. It corresponds to a 1-parameter family of embeddings of T*SL(2,C) in twistor space, and its action preserves the intrinsic geometry while changing the extrinsic one - that is the boosts among polyhedra. We discuss the implication of this action from a dynamical point of view, and compare it with a discretisation of the dilatation generator of the continuum phase space, given by the Lie derivative of the group character. At leading order in the continuu...

  9. Functional and structural analysis of GP64, the major envelope glycoprotein of the budded virus phenotype of Autographa californica and Orgyia pseudotsugata multicapsid nucleopolyhedroviruses

    NARCIS (Netherlands)

    Oomens, A.G.P.

    1999-01-01

    The Baculoviridae are a family of large, enveloped, double-stranded DNA viruses, that cause severe disease in the larvae of mostly lepidopteran insects. Baculoviruses have been studied with the aim of developing alternatives to chemical pest control, and later for their potential as systems for fore

  10. Twisted Chern-Simons supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Castellani, L. [Dipartimento di Scienze e Innovazione Tecnologica, Univ. del Piemonte Orientale, Alessandria (Italy); INFN Gruppo collegato di Alessandria (Italy)

    2014-09-11

    We present a noncommutative version of D = 5 Chern-Simons supergravity, where noncommutativity is encoded in a *-product associated to an abelian Drinfeld twist. The theory is invariant under diffeomorphisms, and under the *-gauge supergroup SU(2,2 vertical stroke 4), including Lorentz and N = 4 local supersymmetries. (Copyright copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  11. Counting Polyominoes on Twisted Cylinders

    OpenAIRE

    Barequet, Gill; Moffie, Micha; Ribó, Ares; Rote, Günter

    2005-01-01

    International audience; We improve the lower bounds on Klarner's constant, which describes the exponential growth rate of the number of polyominoes (connected subsets of grid squares) with a given number of squares. We achieve this by analyzing polyominoes on a different surface, a so-called $\\textit{twisted cylinder}$ by the transfer matrix method. A bijective representation of the "states'' of partial solutions is crucial for allowing a compact representation of the successive iteration vec...

  12. NanoARPES of twisted bilayer graphene on SiC: absence of velocity renormalization for small angles.

    Science.gov (United States)

    Razado-Colambo, I; Avila, J; Nys, J-P; Chen, C; Wallart, X; Asensio, M-C; Vignaud, D

    2016-06-06

    The structural and electronic properties of twisted bilayer graphene (TBG) on SiC(000) grown by Si flux-assisted molecular beam epitaxy were investigated using scanning tunneling microscopy (STM) and angle-resolved photoelectron spectroscopy with nanometric spatial resolution. STM images revealed a wide distribution of twist angles between the two graphene layers. The electronic structure recorded in single TBG grains showed two closely-spaced Dirac π bands associated to the two stacked layers with respective twist angles in the range 1-3°. The renormalization of velocity predicted in previous theoretical calculations for small twist angles was not observed.

  13. Optical Twist Induced by Plasmonic Resonance

    Science.gov (United States)

    Chen, Jun; Wang, Neng; Cui, Liyong; Li, Xiao; Lin, Zhifang; Ng, Jack

    2016-06-01

    Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutual scattering or light exchange to exhibit a conspicuously enhanced optical torque without large extinction or absorption cross section. The torque on each object is almost equal but opposite, which we called optical twist. The effect is quite significant for plasmonic particle cluster, but can also be observed in structures with other morphologies. Such approach exhibits an unprecedentedly large torque to light extinction or absorption ratio, enabling limited light to exert a relatively large torque without severe heating. Our work contributes to the understanding of optical torque and introduces a novel way to manipulate the internal degrees of freedom of a structured particle cluster.

  14. Data envelopment analysis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This review introduces the history and present status of data envelopment analysis (DEA) research, particularly the evaluation process. And extensions of some DEA models are also described. It is pointed out that mathematics, economics and management science are the main forces in the DEA development, optimization provides the fundamental method for the DEA research, and the wide range of applications enforces the rapid development of DEA.

  15. Internal mail envelopes

    CERN Multimedia

    2003-01-01

    Internal mail envelopes often finish up in large piles in certain offices, thus creating a shortage for other users of the mail service, who would be grateful if everyone with an unusual stock could deposit them in their mail box, after attaching them together with an elastic band or piece of string. The messengers will then collect them so that the Mail Office can put them back in circulation. Thank you for your understanding and collaboration. Mail Office

  16. URGENT - Internal Mail Envelopes

    CERN Multimedia

    2007-01-01

    Internal mail envelopes often finish up in large piles in certain offices, thus creating a shortage for other users of the mail service, who would be grateful if everyone with an unused stock could deposit them in their mail box, after attaching them together with an elastic band or piece of string. The messengers will then collect them so that the Mail Office can put them back in circulation. Thank you for your understanding and collaboration. Mail Office

  17. Increased bone formation and decreased osteocalcin expression induced by reduced Twist dosage in Saethre-Chotzen syndrome.

    Science.gov (United States)

    Yousfi, M; Lasmoles, F; Lomri, A; Delannoy, P; Marie, P J

    2001-05-01

    The Saethre-Chotzen syndrome is characterized by premature fusion of cranial sutures resulting from mutations in Twist, a basic helix-loop-helix (bHLH) transcription factor. We have identified Twist target genes using human mutant calvaria osteoblastic cells from a child with Saethre-Chotzen syndrome with a Twist mutation that introduces a stop codon upstream of the bHLH domain. We observed that Twist mRNA and protein levels were reduced in mutant cells and that the Twist mutation increased cell growth in mutant osteoblasts compared with control cells. The mutation also caused increased alkaline phosphatase and type I collagen expression independently of cell growth. During in vitro osteogenesis, Twist mutant cells showed increased ability to form alkaline phosphatase-positive bone-like nodular structures associated with increased type I collagen expression. Mutant cells also showed increased collagen synthesis and matrix production when cultured in aggregates, as well as an increased capacity to form a collagenous matrix in vivo when transplanted into nude mice. In contrast, Twist mutant osteoblasts displayed a cell-autonomous reduction of osteocalcin mRNA expression in basal conditions and during osteogenesis. The data show that genetic deletion of Twist causing reduced Twist dosage increases cell growth, collagen expression, and osteogenic capability, but inhibits osteocalcin gene expression. This provides one mechanism that may contribute to the premature cranial ossification induced by deletion of the bHLH Twist domain in Saethre-Chotzen syndrome.

  18. Analysis of Twisting of Cellulose Nanofibrils in Atomistic Molecular Dynamics Simulations

    DEFF Research Database (Denmark)

    Paavilainen, S.; Rog, T.; Vattulainen, I.

    2011-01-01

    We use atomistic molecular dynamics simulations to study the crystal structure of cellulose nanofibrils, whose sizes are comparable with the crystalline parts in commercial nanocellulose. The simulations show twisting, whose rate of relaxation is strongly temperature dependent. Meanwhile, no sign......We use atomistic molecular dynamics simulations to study the crystal structure of cellulose nanofibrils, whose sizes are comparable with the crystalline parts in commercial nanocellulose. The simulations show twisting, whose rate of relaxation is strongly temperature dependent. Meanwhile......, no significant bending or stretching of nanocellulose is discovered. Considerations of atomic-scale interaction patterns bring about that the twisting arises from hydrogen bonding within and between the chains in a fibril....

  19. Inhibition of enveloped viruses infectivity by curcumin.

    Directory of Open Access Journals (Sweden)

    Tzu-Yen Chen

    Full Text Available Curcumin, a natural compound and ingredient in curry, has antiinflammatory, antioxidant, and anticarcinogenic properties. Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment. We evaluated the effects of curcumin on the membrane structure using fluorescent dye (sulforhodamine B; SRB-containing liposomes that mimic the viral envelope. Curcumin treatment induced the leakage of SRB from these liposomes and the addition of the influenza virus reduced the leakage, indicating that curcumin disrupts the integrity of the membranes of viral envelopes and of liposomes. When testing liposomes of various diameters, we detected higher levels of SRB leakage from the smaller-sized liposomes than from the larger liposomes. Interestingly, the curcumin concentration required to reduce plaque formation was lower for the influenza virus (approximately 100 nm in diameter than for the pseudorabies virus (approximately 180 nm and the vaccinia virus (roughly 335 × 200 × 200 nm. These data provide insights on the molecular antiviral mechanisms of curcumin and its potential use as an antiviral agent for enveloped viruses.

  20. The Wasp-Waist Nebula: VLA Ammonia Observations of the Molecular Core Envelope In a Unique Class 0 Protostellar System

    Science.gov (United States)

    Wiseman, Jennifer; Barsony, M.; Sahai, R.

    2010-01-01

    The Wasp-Waist Nebula was discovered in the IRAC c2d survey of the Ophiuchus star-forming clouds. It is powered by a well-isolated, low-luminosity, low-mass Class 0 object. Its weak outflow has been mapped in the CO (3-2) transition with the JCMT, in 2.12 micron H2 emission with WIRC (the Wide-Field Infrared Camera) on the Hale 5-meter, and, most recently, in six H2 mid-infrared lines with the IRS (InfraRed Spectrograph) on-board the Spitzer Space Telescope; possible jet twisting structure may be evidence of unique core dynamics. Here, we report results of recent VLA ammonia mapping observations of the dense gas envelope feeding the central core protostellar system. We describe the morphology, kinematics, and angular momentum characteristics of this unique system. The results are compared with the envelope structure deduced from IRAC 8-micron absorption of the PAH (polycyclic aromatic hydrocarbon) background emission from the cloud.

  1. Shape Control of Responsive Building Envelopes

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning; Christensen, Jesper Thøger

    2010-01-01

    alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock-up concept of a secondary...

  2. Coronal heating by the partial relaxation of twisted loops

    CERN Document Server

    Bareford, Michael; Browning, Philippa

    2012-01-01

    Context: Relaxation theory offers a straightforward method for estimating the energy that is released when a magnetic field becomes unstable, as a result of continual convective driving. Aims: We present new results obtained from nonlinear magnetohydrodynamic (MHD) simulations of idealised coronal loops. The purpose of this work is to determine whether or not the simulation results agree with Taylor relaxation, which will require a modified version of relaxation theory applicable to unbounded field configurations. Methods: A three-dimensional (3D) MHD Lagrangian-remap code is used to simulate the evolution of a line-tied cylindrical coronal loop model. This model comprises three concentric layers surrounded by a potential envelope; hence, being twisted locally, each loop configuration is distinguished by a piecewise-constant current profile. Initially, all configurations carry zero-net-current fields and are in ideally unstable equilibrium. The simulation results are compared with the predictions of helicity ...

  3. Drug design from the cryptic inhibitor envelope.

    Science.gov (United States)

    Lee, Chul-Jin; Liang, Xiaofei; Wu, Qinglin; Najeeb, Javaria; Zhao, Jinshi; Gopalaswamy, Ramesh; Titecat, Marie; Sebbane, Florent; Lemaitre, Nadine; Toone, Eric J; Zhou, Pei

    2016-02-25

    Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibitors of LpxC--an essential enzyme of the lipid A biosynthetic pathway in Gram-negative bacteria and a validated novel antibiotic target--access alternative, minor population states in solution in addition to the ligand conformation observed in crystal structures. These conformations collectively delineate an inhibitor envelope that is invisible to crystallography, but is dynamically accessible by small molecules in solution. Drug design exploiting such a hidden inhibitor envelope has led to the development of potent antibiotics with inhibition constants in the single-digit picomolar range. The principle of the cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns to yield improved therapeutics.

  4. Drug design from the cryptic inhibitor envelope

    Science.gov (United States)

    Lee, Chul-Jin; Liang, Xiaofei; Wu, Qinglin; Najeeb, Javaria; Zhao, Jinshi; Gopalaswamy, Ramesh; Titecat, Marie; Sebbane, Florent; Lemaitre, Nadine; Toone, Eric J.; Zhou, Pei

    2016-01-01

    Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibitors of LpxC—an essential enzyme of the lipid A biosynthetic pathway in Gram-negative bacteria and a validated novel antibiotic target—access alternative, minor population states in solution in addition to the ligand conformation observed in crystal structures. These conformations collectively delineate an inhibitor envelope that is invisible to crystallography, but is dynamically accessible by small molecules in solution. Drug design exploiting such a hidden inhibitor envelope has led to the development of potent antibiotics with inhibition constants in the single-digit picomolar range. The principle of the cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns to yield improved therapeutics. PMID:26912110

  5. Investigation of Propagation Characteristics of Twisted Hollow Waveguides for Particle Accelerator Applications

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Joshua Lee [Univ. of Tennessee, Knoxville, TN (United States)

    2008-12-01

    A new class of accelerating structures employing a uniformly twisted waveguide is investigated. Twisted waveguides of various cross-sectional geometries are considered and analyzed. It is shown that such a twisted waveguide can support waves that travel at a speed slower than the speed of light c. The slow-wave properties of twisted structures are of interest because these slow-wave electromagnetic fields can be used in applications such as electron traveling wave tubes and linear particle accelerators. Since there is no exact closed form solution for the electromagnetic fields within a twisted waveguide or cavity, several previously proposed approximate methods are examined, and more effcient approaches are developed. It is found that the existing perturbation theory methods yield adequate results for slowly twisted structures; however, our efforts here are geared toward analyzing rapidly twisted structures using modifed finite difference methods specially suited for twisted structures. Although the method can handle general twisted structures, three particular cross sections are selected as representative cases for careful analysis. First, a slowly twisted rectangular cavity is analyzed as a reference case. This is because its shape is simple and perturbation theory already gives a good approximate solution for such slow twists rates. Secondly, a symmetrically notched circular cross section is investigated, since its longitudinal cross section is comparable to the well known disk-loaded cavity (used in many practical accelerator designs, including SLAC). Finally, a "dumbbell" shaped cross section is analyzed because of its similarity to the well-known TESLA-type accelerating cavity, which is of great importance because of its wide acceptance as a superconducting cavity. To validate the results of the developed theory and our extensive simulations, the newly developed numerical models are compared to commercial codes. Also, several prototypes are developed

  6. Envelope Soliton in Solar Radio Emission

    Institute of Scientific and Technical Information of China (English)

    WANG De-Yu; Wangde; G. P. Chernov

    2000-01-01

    Several envelope soliton fine structures have been observed in solar radio metric-wave emission. We present amodel of 1ongitudinal modulational instability to explain these fine structures. It is found that this instability canonly occur in the condition of sound velocity being larger than Alfven velocity in corona. Therefore, the envelopesoliton fine structures should display in the coronal region with high temperature and low magnetic field, whichcorresponds to the solar radio emission in the region of meter and decameter wavelength.

  7. The Twist Limit for Bipolar Active Regions

    Science.gov (United States)

    Moore, Ron; Falconer, David; Gary, Allen

    2008-01-01

    We present new evidence that further supports the standard idea that active regions are emerged magnetic-flux-rope omega loops. When the axial magnetic twist of a cylindrical flux rope exceeds a critical amount, the flux rope becomes unstable to kinking, and the excess axial twist is converted into writhe twist by the kinking. This suggests that, if active regions are emerged omega loops, then (1) no active region should have magnetic twist much above the limit set by kinking, (2) active regions having twist near the limit should often arise from kinked omega loops, and (3) since active regions having large delta sunspots are outstandingly twisted, these arise from kinked omega loops and should have twist near the limit for kinking. From each of 36 vector magnetograms of bipolar active regions, we have measured (1) the total flux of the vertical field above 100 G, (2) the area covered by this flux, and (3) the net electric current that arches over the polarity inversion line. These three quantities yield an estimate of the axial magnetic twist in a simple model cylindrical flux rope that corresponds to the top of the active region s hypothetical omega loop prior to emergence. In all 36 cases, the estimated twist is below the critical limit for kinking. The 11 most twisted active regions (1) have estimated twist within a factor of approx.3 of the limit, and (2) include all of our 6 active regions having large delta sunspots. Thus, our observed twist limit for bipolar active regions is in good accord with active regions being emerged omega loops.

  8. DVCS amplitude with kinematical twist-3 terms

    CERN Document Server

    Radyushkin, A V

    2000-01-01

    We compute the amplitude of deeply virtual Compton scattering (DVCS) using the calculus of QCD string operators in coordinate representation. To restore the electromagnetic gauge invariance (transversality) of the twist-2 amplitude we include the operators of twist-3 which appear as total derivatives of twist-2 operators. Our results are equivalent to a Wandzura-Wilczek approximation for twist-3 skewed parton distributions. We find that this approximation gives a finite result for the amplitude of a longitudinally polarized virtual photon, while the amplitude for transverse polarization is divergent, i.e., factorization breaks down in this term.

  9. Three-Dimensional Structure of the Enveloped Bacteriophage Φ12: An Incomplete T = 13 Lattice Is Superposed on an Enclosed T = 1 Shell

    OpenAIRE

    Wei, Hui; Cheng, R. Holland; Berriman, John; Rice, William J; Stokes, David L.; Katz, A.; Morgan, David Gene; Gottlieb, Paul

    2009-01-01

    Background Bacteriophage φ12 is a member of the Cystoviridae, a unique group of lipid containing membrane enveloped bacteriophages that infect the bacterial plant pathogen Pseudomonas syringae pv. phaseolicola. The genomes of the virus species contain three double-stranded (dsRNA) segments, and the virus capsid itself is organized in multiple protein shells. The segmented dsRNA genome, the multi-layered arrangement of the capsid and the overall viral replication scheme make the Cystoviridae s...

  10. Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival

    Directory of Open Access Journals (Sweden)

    Alimujiang Wushou

    2014-11-01

    Full Text Available Epithelial-to-mesenchymal transition (EMT facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was found to be a key factor in the promotion of metastasis of cancer cells, and is known to induce EMT. Twist-1 participation in carcinoma progression and metastasis has been reported in a variety of tumors. However, controversy exists concerning the correlation between Twist-1 and prognostic value with respect to carcinoma. A systematic review and meta-analysis were performed to determine whether the expression of Twist-1 was associated with the prognosis of carcinoma patients. This analysis included 17 studies: four studies evaluated lung cancer, three evaluated head and neck cancer, two evaluated breast cancer, two evaluated esophageal cancer, two evaluated liver cancer and one each evaluated osteosarcoma, bladder, cervical and ovarian cancer. A total of 2006 patients were enrolled in these studies, and the median trial sample size was 118 patients. Twist-1 expression was associated with worse overall survival (OS at both 3 years (hazard ratio “HR” for death = 2.13, 95% CI = 1.86 to 2.45, p < 0.001 and 5 years (HR for death = 2.01, 95% CI = 1.76 to 2.29, p < 0.001. Expression of Twist-1 is associated with worse survival in carcinoma.

  11. Twisted Polynomials and Forgery Attacks on GCM

    DEFF Research Database (Denmark)

    Abdelraheem, Mohamed Ahmed A. M. A.; Beelen, Peter; Bogdanov, Andrey;

    2015-01-01

    nonce misuse resistance, such as POET. The algebraic structure of polynomial hashing has given rise to security concerns: At CRYPTO 2008, Handschuh and Preneel describe key recovery attacks, and at FSE 2013, Procter and Cid provide a comprehensive framework for forgery attacks. Both approaches rely...... heavily on the ability to construct forgery polynomials having disjoint sets of roots, with many roots (“weak keys”) each. Constructing such polynomials beyond naïve approaches is crucial for these attacks, but still an open problem. In this paper, we comprehensively address this issue. We propose to use...... in an improved key recovery algorithm. As cryptanalytic applications of our twisted polynomials, we develop the first universal forgery attacks on GCM in the weak-key model that do not require nonce reuse. Moreover, we present universal weak-key forgeries for the nonce-misuse resistant AE scheme POET, which...

  12. Energy release in driven twisted coronal loops

    CERN Document Server

    Bareford, M R; Browning, P K; Hood, A W

    2015-01-01

    In the present study we investigate magnetic reconnection in twisted magnetic fluxtubes with different initial configurations. In all considered cases, energy release is triggered by the ideal kink instability, which is itself the result of applying footpoint rotation to an initially potential field. The main goal of this work is to establish the influence of the field topology and various thermodynamic effects on the energy release process. Specifically, we investigate convergence of the magnetic field at the loop footpoints, atmospheric stratification, as well as thermal conduction. In all cases, the application of vortical driving at the footpoints of an initally potential field leads to an internal kink instability. With the exception of the curved loop with high footpoint convergence, the global geometry of the loop change little during the simulation. Footpoint convergence, curvature and atmospheric structure clearly influences the rapidity with which a loop achieves instability as well as the size of t...

  13. Twisted conjugacy in braid groups

    CERN Document Server

    González-Meneses, Juan

    2011-01-01

    In this note we solve the twisted conjugacy problem for braid groups, i.e. we propose an algorithm which, given two braids $u,v\\in B_n$ and an automorphism $\\phi \\in Aut (B_n)$, decides whether $v=(\\phi (x))^{-1}ux$ for some $x\\in B_n$. As a corollary, we deduce that each group of the form $B_n \\rtimes H$, a semidirect product of the braid group $B_n$ by a torsion-free hyperbolic group $H$, has solvable conjugacy problem.

  14. Uncertain data envelopment analysis

    CERN Document Server

    Wen, Meilin

    2014-01-01

    This book is intended to present the milestones in the progression of uncertain Data envelopment analysis (DEA). Chapter 1 gives some basic introduction to uncertain theories, including probability theory, credibility theory, uncertainty theory and chance theory. Chapter 2 presents a comprehensive review and discussion of basic DEA models. The stochastic DEA is introduced in Chapter 3, in which the inputs and outputs are assumed to be random variables. To obtain the probability distribution of a random variable, a lot of samples are needed to apply the statistics inference approach. Chapter 4

  15. Design studies for twist-coupled wind turbine blades.

    Energy Technology Data Exchange (ETDEWEB)

    Valencia, Ulyses (Wichita State University, Wichita, KS); Locke, James (Wichita State University, Wichita, KS)

    2004-06-01

    This study presents results obtained for four hybrid designs of the Northern Power Systems (NPS) 9.2-meter prototype version of the ERS-100 wind turbine rotor blade. The ERS-100 wind turbine rotor blade was designed and developed by TPI composites. The baseline design uses e-glass unidirectional fibers in combination with {+-}45-degree and random mat layers for the skin and spar cap. This project involves developing structural finite element models of the baseline design and carbon hybrid designs with and without twist-bend coupling. All designs were evaluated for a unit load condition and two extreme wind conditions. The unit load condition was used to evaluate the static deflection, twist and twist-coupling parameter. Maximum deflections and strains were determined for the extreme wind conditions. Linear and nonlinear buckling loads were determined for a tip load condition. The results indicate that carbon fibers can be used to produce twist-coupled designs with comparable deflections, strains and buckling loads to the e-glass baseline.

  16. Editorial Commentary: The Ribbon Theory. Another Quantum Leap? The Anterior Cruciate Ligament Is Twisted and in Fact a Flat Structure. Or not?

    Science.gov (United States)

    Hohmann, Erik

    2017-09-01

    Is the double bundle structure of the anterior cruciate ligament (ACL) a myth? Derotation untwists the ACL and results in a flat ribbon structure. However, other researchers dispute this theory and revealed 2 distinct bundles separated by a synovial septum. The answer is simple: we do not know and the evidence is conflicting. Copyright © 2017 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  17. On the twists of interplanetary magnetic flux ropes observed at 1 AU

    OpenAIRE

    Wang, Yuming; Zhuang, Bin; Hu, Qiang; Liu, Rui; Shen, Chenglong; Chi, Yutian

    2016-01-01

    Magnetic flux ropes (MFRs) are one kind of fundamental structures in the solar physics, and involved in various eruption phenomena. Twist, characterizing how the magnetic field lines wind around a main axis, is an intrinsic property of MFRs, closely related to the magnetic free energy and stableness. So far it is unclear how much amount of twist is carried by MFRs in the solar atmosphere and in heliosphere and what role the twist played in the eruptions of MFRs. Contrasting to the solar MFRs,...

  18. Formulation of the twisted-light--matter interaction at the phase singularity: the twisted-light gauge

    CERN Document Server

    Quinteiro, G F; Kuhn, T

    2014-01-01

    Twisted light is light carrying orbital angular momentum. The profile of such a beam is a ring-like structure with a node at the beam axis, where a phase singularity exits. Due to the strong spatial inhomogeneity the mathematical description of twisted light-matter interaction is non-trivial, in particular at the phase singularity, where the commonly used dipole-moment approximation cannot be applied. In this paper we show theoretically that, if the polarization and the orbital angular momentum of the twisted light beam have the same sign, a Hamiltonian similar to the dipole-moment approximation can be derived. However, if the signs of polarization and orbital angular momentum differ, the magnetic parts of the light beam become of significant importance and an interaction Hamiltonian which only accounts for electric fields, as in the dipole moment approximation, is inappropriate. We discuss the consequences of these findings for twisted light excitation of semiconductor nanostructures, e. g. a quantum dot, pl...

  19. Twisting the N=2 string

    Science.gov (United States)

    Ketov, Sergei V.; Lechtenfeld, Olaf; Parkes, Andrew J.

    1995-03-01

    The most general homogeneous monodromy conditions in N=2 string theory are classified in terms of the conjugacy classes of the global symmetry group U(1,1)⊗openZ2. For classes which generate a discrete subgroup Γ, the corresponding target space backgrounds openC1,1/Γ include half spaces, complex orbifolds, and tori. We propose a generalization of the intercept formula to matrix-valued twists, but find massless physical states only for Γ=open1 (untwisted) and Γ=openZ2 (in the manner of Mathur and Mukhi), as well as for Γ being a parabolic element of U(1,1). In particular, the 16 openZ2-twisted sectors of the N=2 string are investigated, and the corresponding ground states are identified via bosonization and BRST cohomology. We find enough room for an extended multiplet of ``spacetime'' supersymmetry, with the number of supersymmetries being dependent on global ``spacetime'' topology. However, world-sheet locality for the chiral vertex operators does not permit interactions among all massless ``spacetime'' fermions.

  20. Symmetry fractionalization and twist defects

    Science.gov (United States)

    Tarantino, Nicolas; Lindner, Netanel H.; Fidkowski, Lukasz

    2016-03-01

    Topological order in two-dimensions can be described in terms of deconfined quasiparticle excitations—anyons—and their braiding statistics. However, it has recently been realized that this data does not completely describe the situation in the presence of an unbroken global symmetry. In this case, there can be multiple distinct quantum phases with the same anyons and statistics, but with different patterns of symmetry fractionalization—termed symmetry enriched topological order. When the global symmetry group G, which we take to be discrete, does not change topological superselection sectors—i.e. does not change one type of anyon into a different type of anyon—one can imagine a local version of the action of G around each anyon. This leads to projective representations and a group cohomology description of symmetry fractionalization, with the second cohomology group {H}2(G,{{ A }}{{abelian}}) being the relevant group. In this paper, we treat the general case of a symmetry group G possibly permuting anyon types. We show that despite the lack of a local action of G, one can still make sense of a so-called twisted group cohomology description of symmetry fractionalization, and show how this data is encoded in the associativity of fusion rules of the extrinsic ‘twist’ defects of the symmetry. Furthermore, building on work of Hermele (2014 Phys. Rev. B 90 184418), we construct a wide class of exactly-solvable models which exhibit this twisted symmetry fractionalization, and connect them to our formal framework.

  1. Multiple Twisted -Euler Numbers and Polynomials Associated with -Adic -Integrals

    Directory of Open Access Journals (Sweden)

    Jang Lee-Chae

    2008-01-01

    Full Text Available By using -adic -integrals on , we define multiple twisted -Euler numbers and polynomials. We also find Witt's type formula for multiple twisted -Euler numbers and discuss some characterizations of multiple twisted -Euler Zeta functions. In particular, we construct multiple twisted Barnes' type -Euler polynomials and multiple twisted Barnes' type -Euler Zeta functions. Finally, we define multiple twisted Dirichlet's type -Euler numbers and polynomials, and give Witt's type formula for them.

  2. A robotic finger driven by twisted and coiled polymer actuator

    Science.gov (United States)

    Cho, Kyeong Ho; Song, Min Geun; Jung, Hosang; Park, Jungwoo; Moon, Hyungpil; Koo, Ja Choon; Nam, Jae-Do; Choi, Hyouk Ryeol

    2016-04-01

    Previous studies reported that a twisted and coiled polymer actuator (TCA) generates strong force and large stroke by heating. Nylon 6,6 is known to be the most suitable polymer material for TCA because it has high thermal expansion ratio, high softening point and high toughness which is able to sustain gigantic twisting. In order to find the optimal structure of TCA fabricated with silver-coated nylon sewing threads, an equipment for twist-insertion (structuralization), composed of single DC motor, a slider fabricated by 3D printer and a body frame, is developed. It can measure the behaviors of TCAs as well as fabricate TCAs with desired characteristics by structuralizing fibers with controlled rotation per minutes (RPM) and turns. Comparing performances of diverse structures of TCAs, the optimal structure for TCA is found. For the verification of the availability of the optimal TCA, a TCA-driven biomimetic finger is developed. Finally, we successfully demonstrate the flexion/extension of the finger by using the actuation of TCAs.

  3. Large N reduction on a twisted torus

    CERN Document Server

    González-Arroyo, A; Neuberger, H

    2005-01-01

    We consider SU(N) lattice gauge theory at infinite N defined on a torus with a CP invariant twist. Massless fermions are incorporated in an elegant way, while keeping them quenched. We present some numerical results which suggest that twisting can make numerical simulations of planar QCD more efficient.

  4. Stress effects in twisted highly birefringent fibers

    Science.gov (United States)

    Wolinski, Tomasz R.

    1994-03-01

    Hydrostatic pressure and uniaxial longitudinal strain effects in twisted highly birefringent optical fibers have been investigated from the point of the Marcuse mode-coupling theory. The problem is analyzed in terms of local normal modes of the ideal fiber and in the limit of weak twist, where large linear birefringence dominates over twist effect, and therefore twist coupling between local modes is not effective. The authors present the results of birefringence measurements in highly birefringent bow-tie fibers influenced simultaneously by hydrostatic pressure up to 100 MPa and twisting the result for highly birefringent elliptical-core fibers influenced by uniaxial longitudinal strain up to 4000 (mu) (epsilon) and twisting effect. The birefringence measurement method is based on twist-induced effects and has been successfully applied in a stress environment. The experiment was conducted with a specially designed stress generating device that makes it possible to simultaneously generate various mechanical perturbations such as hydrostatic and radial pressure, axial strain and twist, allowing study of their influence on mode propagation in optical fibers. A comparison with theoretical results as well as with pervious experimental data on stress influence on the beat length parameter in highly birefringent fibers is also provided.

  5. Decay constants from twisted mass QCD

    CERN Document Server

    Dimopoulos, P; Michael, C; Simula, S; Urbach, C

    2008-01-01

    We present results for chiral extrapolations of the mass and decay constants of the rho meson. The data sets used are the nf=2 unquenched gauge configurations generated with twisted mass fermions by the European Twisted Mass Collaboration. We describe a calculation of three decay constants in charmonium and explain why they are required.

  6. Twisting theory for weak Hopf algebras

    Institute of Scientific and Technical Information of China (English)

    CHEN Ju-zhen; ZHANG Yan; WANG Shuan-hong

    2008-01-01

    The main aim of this paper is to study the twisting theory of weak Hopf algebras and give an equivalence between the (braided) monoidal categories of weak Hopf bimodules over the original and the twisted weak Hopf algebra to generalize the result from Oeckl (2000).

  7. N=4 Twisted Superspace from Dirac-Kahler Twist and Off-shell SUSY Invariant Actions in Four Dimensions

    CERN Document Server

    Kato, J; Miyake, A; Kato, Junji; Kawamoto, Noboru; Miyake, Akiko

    2005-01-01

    We propose N=4 twisted superspace formalism in four dimensions by introducing Dirac-Kahler twist. In addition to the BRST charge as a scalar counter part of twisted supercharge we find vector and tensor twisted supercharges. By introducing twisted chiral superfield we explicitly construct off-shell twisted N=4 SUSY invariant action. We can propose variety of supergauge invariant actions by introducing twisted vector superfield. We may, however, need to find further constraints to identify twisted N=4 super Yang-Mills action. We propose a superconnection formalism of twisted superspace where constraints play a crucial role. It turns out that N=4 superalgebra of Dirac-Kahler twist can be decomposed into N=2 sectors. We can then construct twisted N=2 super Yang-Mills actions by the superconnection formalism of twisted superspace in two and four dimensions.

  8. Hidden Beauty in Twisted Viking Neck Rings

    CERN Document Server

    Olsen, Kasper

    2010-01-01

    Many hoards found in Ireland, Scotland, Orkney Islands, and Scandinavia demonstrate the vikings ability to fabricate beautiful arm and neck rings of twisted silver and gold rods. Characteristic for such rings is the uniform appearance of the twisted pattern along the length of the arm ring, as well as from one arm ring to another, also when found at distant geographical locations. How can the appearance of the twisted wires be so perfectly repetitive? We demonstrate that the answer is that the vikings utilized a self-forming motif: The pattern arises from a twisting of the wires to a maximally rotated configuration. That is why the twist patterns in these arm and neck rings are beautiful, repetitive, and universal.

  9. On the twists of interplanetary magnetic flux ropes observed at 1 AU

    CERN Document Server

    Wang, Yuming; Hu, Qiang; Liu, Rui; Shen, Chenglong; Chi, Yutian

    2016-01-01

    Magnetic flux ropes (MFRs) are one kind of fundamental structures in the solar physics, and involved in various eruption phenomena. Twist, characterizing how the magnetic field lines wind around a main axis, is an intrinsic property of MFRs, closely related to the magnetic free energy and stableness. So far it is unclear how much amount of twist is carried by MFRs in the solar atmosphere and in heliosphere and what role the twist played in the eruptions of MFRs. Contrasting to the solar MFRs, there are lots of in-situ measurements of magnetic clouds (MCs), the large-scale MFRs in interplanetary space, providing some important information of the twist of MFRs. Thus, starting from MCs, we investigate the twist of interplanetary MFRs with the aid of a velocity-modified uniform-twist force-free flux rope model. It is found that most of MCs can be roughly fitted by the model and nearly half of them can be fitted fairly well though the derived twist is probably over-estimated by a factor of 2.5. By applying the mod...

  10. Discussion on the Application of Energy-saving Technology in Building External Envelope Structure Design%节能技术在建筑外围护结构设计中的应用刍议

    Institute of Scientific and Technical Information of China (English)

    包玉鹏

    2013-01-01

    In today’s increasingly economic development soc-iety, energy consumption is more and more fast, the importa-nce of energy is more and more prominent. This paper mainly introduces the several methods of energy-saving design in the building external envelope structure, discusses the energy-savi-ng of building envelope structure like wal s, doors and wind-ows, roofing and other aspects, in order to improve the effect of building structure energy saving.%在当今经济日益发展,能源消耗速度越来越快的社会里,能源的重要性越来越凸显。本文主要简单介绍了对建筑外围护结构进行节能设计的几种方法,针对建筑外围结构中的外墙、门窗、屋面等方面的节能进行探讨,以提高建筑结构的节能效果。

  11. Application of a real-space three-dimensional image reconstruction method in the structural analysis of noncrystalline biological macromolecules enveloped by water in coherent x-ray diffraction microscopy.

    Science.gov (United States)

    Kodama, Wataru; Nakasako, Masayoshi

    2011-08-01

    Coherent x-ray diffraction microscopy is a novel technique in the structural analyses of particles that are difficult to crystallize, such as the biological particles composing living cells. As water is indispensable for maintaining particles in functional structures, sufficient hydration of targeted particles is required during sample preparation for diffraction microscopy experiments. However, the water enveloping particles also contributes significantly to the diffraction patterns and reduces the electron-density contrast of the sample particles. In this study, we propose a protocol for the structural analyses of particles in water by applying a three-dimensional reconstruction method in real space for the projection images phase-retrieved from diffraction patterns, together with a developed density modification technique. We examined the feasibility of the protocol through three simulations involving a protein molecule in a vacuum, and enveloped in either a droplet or a cube-shaped water. The simulations were carried out for the diffraction patterns in the reciprocal planes normal to the incident x-ray beam. This assumption and the simulation conditions corresponded to experiments using x-ray wavelengths of shorter than 0.03 Å. The analyses demonstrated that our protocol provided an interpretable electron-density map. Based on the results, we discuss the advantages and limitations of the proposed protocol and its practical application for experimental data. In particular, we examined the influence of Poisson noise in diffraction patterns on the reconstructed three-dimensional electron density in the proposed protocol.

  12. The geometrical origin of the strain-twist coupling in double helices

    CERN Document Server

    Olsen, Kasper

    2010-01-01

    The geometrical coupling between strain and twist in double helices is investigated. Overwinding, where strain leads to further winding, is shown to be a universal property for helices, which are stretched along their longitudinal axis when the initial pitch angle is below the zero-twist angle (39.4). Unwinding occurs at larger pitch angles. The zero-twist angle is the unique pitch angle at the point between overwinding and unwinding, and it is independent of the mechanical properties of the double helix. This suggests the existence of zero-twist structures, i.e. structures that display neither overwinding, nor unwinding under strain. Estimates of the overwinding of DNA, chromatin, and RNA are given.

  13. Nonlinear Analysis of Airship Envelop Aerolasticity

    Science.gov (United States)

    Liu, J. M.; Lu, C. J.; Xue, L. P.

    The large airship in flow field is a flexible body with low rigidity. The distribution of the peripheral flow field around the airship is closely related to its shape. It is essentially one of the Fluid-structure Interaction problems. Based on this, this paper aims at the numerical simulation of nonlinear airship envelop aeroelasticity by means of coupling aerodynamics and structure using an iteration method. The three-dimensional flow around the airship was studied numerically by means of SIMPLE method based on the Finite Volume Method. Two approaches, the linear method whose equilibrium equations are based on the membrance theory of thin shell and the nonlinear method which uses a nonlinear finite element method to account for the large deformation of the airship envelop, are introduced for geometrically deformation of the airship shape. A thin plate spline method is adopted as the interface of exchanging information between the fluid and structure models.

  14. The Dependency of Nematic and Twist-bend Mesophase Formation on Bend Angle

    Science.gov (United States)

    Mandle, Richard J.; Archbold, Craig T.; Sarju, Julia P.; Andrews, Jessica L.; Goodby, John W.

    2016-11-01

    We have prepared and studied a family of cyanobiphenyl dimers with varying linking groups with a view to exploring how molecular structure dictates the stability of the nematic and twist-bend nematic mesophases. Using molecular modelling and 1D 1H NOESY NMR spectroscopy, we determine the angle between the two aromatic core units for each dimer and find a strong dependency of the stability of both the nematic and twist-bend mesophases upon this angle, thereby satisfying earlier theoretical models.

  15. The Importance of Higher Twist Corrections in Polarized DIS

    CERN Document Server

    Leader, Elliot; Stamenov, D B

    2003-01-01

    The higher twist corrections $h^N(x)/Q^2$ to the spin dependent proton and neutron $g_1$ structure functions are extracted from the world data on $g_1(x,Q^2)$ in a model independent way and found to be non-negligible. Their role in determining the polarized parton densities in the nucleon is discussed. It is also considered how the results are influenced by the recent JLab and HERMES/d inclusive DIS data.

  16. Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

    Institute of Scientific and Technical Information of China (English)

    Qian Qin; Young Xu; Tao He; Chunlin Qin; Jianming Xu

    2012-01-01

    This article reviews the molecular structure,expression pattern,physiological function,pathological roles and molecular mechanisms of Twist1 in development,genetic disease and cancer.Twist1 is a basic helix-loop-helix domaincontaining transcription factor.It forms homo- or hetero-dimers in order to bind the Nde1 E-box element and activate or repress its target genes.During development,Twistl is essential for mesoderm specification and differentiation.Heterozygous loss-of-function mutations of the human Twist1 gene cause several diseases including the SaethreChotzen syndrome.The Twist1-null mouse embryos die with unclosed cranial neural tubes and defective head mesenchyme,somites and limb buds.Twist1 is expressed in breast,liver,prostate,gastric and other types of cancers,and its expression is usually associated with invasive and metastatic cancer phenotypes.In cancer cells,Twistl is upregulated by multiple factors including SRC-1,STAT3,MSX2,HIF-1α,integrin-linked kinase and NF-κB.Twist1 significantly enhances epithelial-mesenchymal transition (EMT) and cancer cell migration and invasion,hence promoting cancer metastasis.Twistl promotes EMT in part by directly repressing E-cadherin expression by recruiting the nucleosome remodeling and deacetylase complex for gene repression and by upregulating Bmil,AKT2,YB-1,etc.Emerging evidence also suggests that Twist1 plays a role in expansion and chemotherapeutic resistance of cancer stem cells.Further understanding of the mechanisms by which Twist1 promotes metastasis and identification of Twist1 functional modulators may hold promise for developing new strategies to inhibit EMT and cancer metastasis.

  17. Categories with envelopes and imprints

    CERN Document Server

    Akbarov, Sergei

    2011-01-01

    An envelope in a category is a construction generalizing operations of "exterior completion", like completion of a locally convex space. Dually, an imprint generalizes operations of "interior enrichment", like saturation of a locally convex space. We give abstract definition for envelopes and imprints, prove existence of these objects in the categories of stereotype spaces and of stereotype algebras, and give some examples.

  18. Thermal testing of building envelopes

    Science.gov (United States)

    Lebedev, O.; Kirzhanov, D.; Avramenko, V.; Budadin, O.

    2006-04-01

    Averaged heat transfer resistance of the building envelope is the primary parameter that determines the energy saving characteristics of the building. At the phase of the building design it is usually taken into account that building must preserve heat effectively. It is mostly important in northern countries where cold seasons last for more than a half of year. Usually infrared methods are used to find mechanical defects of the building envelope. In this article an alternative way to describe the building envelope using infrared camera is presented. The method includes the determination of local heat engineering characteristics of the envelope using contact measurements and the determination of averaged heat transfer resistance of the buildings envelope using its infrared image.

  19. Fast Moreau envelope computation I

    Science.gov (United States)

    Lucet, Yves

    2006-11-01

    The present article summarizes the state of the art algorithms to compute the discrete Moreau envelope, and presents a new linear-time algorithm, named NEP for NonExpansive Proximal mapping. Numerical comparisons between the NEP and two existing algorithms: The Linear-time Legendre Transform (LLT) and the Parabolic Envelope (PE) algorithms are performed. Worst-case time complexity, convergence results, and examples are included. The fast Moreau envelope algorithms first factor the Moreau envelope as several one-dimensional transforms and then reduce the brute force quadratic worst-case time complexity to linear time by using either the equivalence with Fast Legendre Transform algorithms, the computation of a lower envelope of parabolas, or, in the convex case, the non expansiveness of the proximal mapping.

  20. Bend-twist coupling potential of wind turbine blades

    Science.gov (United States)

    Fedorov, V.; Berggreen, C.

    2014-06-01

    In the present study an evaluation of the potential for bend-twist coupling effects in wind turbine blades is addressed. A method for evaluation of the coupling magnitude based on the results of finite element modeling and full-field displacement measurements obtained by experiments is developed and tested on small-scale coupled composite beams. In the proposed method the coupling coefficient for a generic beam is introduced based on the Euler-Bernoulli beam formulation. By applying the developed method for analysis of a commercial wind turbine blade structure it is demonstrated that a bend-twist coupling magnitude of up to 0.2 is feasible to achieve in the baseline blade structure made of glass-fiber reinforced plastics. Further, by substituting the glass-fibers with carbon-fibers the coupling effect can be increased to 0.4. Additionally, the effect of introduction of bend-twist coupling into a blade on such important blade structural properties as bending and torsional stiffness is demonstrated.

  1. 镶嵌式框架围护结构典型节点热桥模拟分析%Simulation Analysis on Thermal Bridge of Typical Nodes of Inlaid Frame Structure in Building Envelope System

    Institute of Scientific and Technical Information of China (English)

    周静; 高岩; 于崇明; 刘然

    2014-01-01

    The building envelope system of inlaid frame structure is introduced. Taking the typical weather condition in Beijing as the computational parameter, it analyzes the temperature distribution on thermal bridge of typical nodes of different inlaid frame structure in building envelope system with simula-tion, the result shows that the system can avoid condensation problems on thermal bridges. Studies about the heat flux distribution in different nodes indicate that the system can basically meet the design standard for energy efficiency of residential buildings in Beijing.%介绍了镶嵌式框架围护结构体系,以北京地区气候条件为计算参数,利用模拟软件,模拟分析了不同形式镶嵌式框架围护结构中典型节点的温度分布规律,结果表明该体系能够避免热桥部分产生结露问题;还分析了不同节点处的热流分布,表明该体系的节能效果可基本满足北京市居住建筑的节能设计要求。

  2. Reversal of helicoidal twist handedness near point defects of confined chiral liquid crystals

    Science.gov (United States)

    Ackerman, Paul J.; Smalyukh, Ivan I.

    2016-05-01

    Handedness of the director twist in cholesteric liquid crystals is commonly assumed to be the same throughout the medium, determined solely by the chirality of constituent molecules or chiral additives, albeit distortions of the ground-state helicoidal configuration often arise due to the effects of confinement and external fields. We directly probe the twist directionality of liquid crystal director structures through experimental three-dimensional imaging and numerical minimization of the elastic free energy and show that spatially localized regions of handedness opposite to that of the chiral liquid crystal ground state can arise in the proximity of twisted-soliton-bound topological point defects. In chiral nematic liquid crystal confined to a film that has a thickness less than the cholesteric pitch and perpendicular surface boundary conditions, twisted solitonic structures embedded in a uniform unwound far-field background with chirality-matched handedness locally relieve confinement-imposed frustration and tend to be accompanied by point defects and smaller geometry-required, energetically costly regions of opposite twist handedness. We also describe a spatially localized structure, dubbed a "twistion," in which a twisted solitonic three-dimensional director configuration is accompanied by four point defects. We discuss how our findings may impinge on the stability of localized particlelike director field configurations in chiral and nonchiral liquid crystals.

  3. DYNAMICS OF STRONGLY TWISTED RELATIVISTIC MAGNETOSPHERES

    Energy Technology Data Exchange (ETDEWEB)

    Parfrey, Kyle [Astronomy Department, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Beloborodov, Andrei M.; Hui, Lam, E-mail: parfrey@astro.princeton.edu [Physics Department and Columbia Astrophysics Laboratory, Columbia University, 538 West 120th Street, New York, NY 10027 (United States)

    2013-09-10

    Magnetar magnetospheres are believed to be strongly twisted due to shearing of the stellar crust by internal magnetic stresses. We present time-dependent axisymmetric simulations showing in detail the evolution of relativistic force-free magnetospheres subjected to slow twisting through large angles. When the twist amplitude is small, the magnetosphere moves quasi-statically through a sequence of equilibria of increasing free energy. At some twist amplitude the magnetosphere becomes tearing-mode unstable to forming a resistive current sheet, initiating large-scale magnetic reconnection in which a significant fraction of the magnetic free energy can be dissipated. This ''critical'' twist angle is insensitive to the resistive length scale. Rapid shearing temporarily stabilizes the magnetosphere beyond the critical angle, allowing the magnetosphere of a rapidly differentially rotating star to store and dissipate more free energy. In addition to these effects, shearing the surface of a rotating star increases the spindown torque applied to the star. If shearing is much slower than rotation, the resulting spikes in spindown rate can occur on timescales anywhere from the long twisting timescale to the stellar spin period or shorter, depending both on the stellar shear distribution and the existing distribution of magnetospheric twists. A model in which energy is stored in the magnetosphere and released by a magnetospheric instability therefore predicts large changes in the measured spindown rate before soft gamma repeater giant flares.

  4. Filamentary Star Formation: Observing the Evolution toward Flattened Envelopes

    CERN Document Server

    Lee, Katherine; Johnstone, Doug; Tobin, John

    2012-01-01

    Filamentary structures are ubiquitous from large-scale molecular clouds (few parsecs) to small-scale circumstellar envelopes around Class 0 sources (~1000 AU to ~0.1 pc). In particular, recent observations with the Herschel Space Observatory emphasize the importance of large-scale filaments (few parsecs) and star formation. The small-scale flattened envelopes around Class 0 sources are reminiscent of the large-scale filaments. We propose an observationally derived scenario for filamentary star formation that describes the evolution of filaments as part of the process for formation of cores and circumstellar envelopes. If such a scenario is correct, small-scale filamentary structures (0.1 pc in length) with higher densities embedded in starless cores should exist, although to date almost all the interferometers have failed to observe such structures. We perform synthetic observations of filaments at the prestellar stage by modeling the known Class 0 flattened envelope in L1157 using both the Combined Array for...

  5. Novel Properties of Twisted-Photon Absorption

    CERN Document Server

    Afanasev, Andrei; Mukherjee, Asmita

    2014-01-01

    We discuss novel features of twisted-photon absorption both by atoms and by micro-particles. First, we extend the treatment of atomic photoexcitation by twisted photons to include atomic recoil, derive generalized quantum selection rules and consider phenomena of forbidden atomic transitions. Second, we analyze the radiation pressure from twisted-photon beams on micro- and nano-sized particles and observe that for particular conditions the pressure is negative in a small area near the beam axis. A central part of the beam therefore acts as a "tractor beam".

  6. Twisted spectral geometry for the standard model

    Science.gov (United States)

    Martinetti, Pierre

    2015-07-01

    In noncommutative geometry, the spectral triple of a manifold does not generate bosonic fields, for fluctuations of the Dirac operator vanish. A Connes-Moscovici twist forces the commutative algebra to be multiplied by matrices. Keeping the space of spinors untouched, twisted-fluctuations then yield perturbations of the spin connection. Applied to the spectral triple of the Standard Model, a similar twist yields the scalar field needed to stabilize the vacuum and to make the computation of the Higgs mass compatible with its experimental value.

  7. Some Aspects of Wave and Quantum Approaches at Description of Movement of Twisted Light

    CERN Document Server

    Portnov, Yuriy A

    2015-01-01

    The existence of twisted light may be inferred from modern quantum concepts and experimental data. These waves possess energy, impulse and angular momentum. However, the Maxwell's four-dimensional theory of electromagnetism does not imply the existence of waves with these properties. This article develops a model generalizing the theory of electromagnetism in such a way that it would be possible to obtain equations of twisted electromagnetic waves. Generalization is implemented by introduction of a space-time with a more complex structure compared to the four-dimensional space-time. Such spaces include a seven-dimensional space-time, which allows to describe not only translational, but also rotational motion of bodies. A model developed by the author provides the following results: 1) generalization of the theory of electromagnetism in which it is possible to obtain equations of twisted light waves, 2) solution describing interference of light waves oppositely twisted, 3) the formula relating the energy, impu...

  8. Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.

    Science.gov (United States)

    Meng, Tian; Huang, Yanyu; Wang, Suzhen; Zhang, Hua; Dechow, Paul C; Wang, Xiaofang; Qin, Chunlin; Shi, Bing; D'Souza, Rena N; Lu, Yongbo

    2015-12-04

    Twist1 is a basic helix-loop-helix-containing transcription factor that is expressed in the dental mesenchyme during the early stages of tooth development. To better delineate its roles in tooth development, we generated Twist1 conditional knockout embryos (Twist2(Cre) (/+);Twist1(fl/fl)) by breeding Twist1 floxed mice (Twist1(fl/fl)) with Twist2-Cre recombinase knockin mice (Twist2(Cre) (/+)). The Twist2(Cre) (/+);Twist1(fl/fl) embryos formed smaller tooth germs and abnormal cusps during early tooth morphogenesis. Molecular and histological analyses showed that the developing molars of the Twist2(Cre) (/+);Twist1(fl/fl) embryos had reduced cell proliferation and expression of fibroblast growth factors 3, 4, 9, and 10 and FGF receptors 1 and 2 in the dental epithelium and mesenchyme. In addition, 3-week-old renal capsular transplants of embryonic day 18.5 Twist2(Cre) (/+);Twist1(fl/fl) molars showed malformed crowns and cusps with defective crown dentin and enamel. Immunohistochemical analyses revealed that the implanted mutant molars had defects in odontoblast differentiation and delayed ameloblast differentiation. Furthermore, in vitro ChIP assays demonstrated that Twist1 was able to bind to a specific region of the Fgf10 promoter. In conclusion, our findings suggest that Twist1 plays crucial roles in regulating tooth development and that it may exert its functions through the FGF signaling pathway. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. Progress in the Determination of Polarized PDFs and Higher Twist

    CERN Document Server

    Leader, Elliot; Stamenov, Dimiter B

    2007-01-01

    The impact of the recent very precise CLAS and COMPASS g1/F1 data on polarized parton densities and higher twist effects is discussed. It is demonstrated that the low Q^2 CLAS data improve essentially our knowledge of higher twist corrections to the spin structure function g1, while the large Q^2 COMPASS data influence mainly the strange quark and gluon polarizations. It is also shown that the uncertainties in the determination of the polarized parton densities are significantly reduced. We find also that the present inclusive DIS data cannot rule out a negative polarized and changing in sign gluon densities. The present status of the proton spin sum rule is discussed.

  10. Higher twist effects in DIS: an outline of diquark contributions

    Energy Technology Data Exchange (ETDEWEB)

    Anselmino, M. [Turin Univ. (Italy). Dipt. di Fisica Teorica]|[Istituto Nazionale di Fisica Nucleare, Turin (Italy); Caruso, F. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil)]|[Universidade do Estado, Rio de Janeiro, RJ (Brazil). Inst. de Fisica

    1996-12-01

    A quark-diquark picture of the nucleon, previously introduced in the description of a several exclusive and inclusive processes at intermediate Q{sup 2} values, is found to accurately model the higher-twist data on the unpolarized proton structure function F{sub 2}{sup p}(x,Q{sup 2}). The main results of the model are summarized. The emerging set of parameters is consistent with the diquark properties suggested by other experimental and theoretical analyses. Higher-twist corrections to the Bjorken and Gottfried sum rule are also estimated in the framework of the same quark-diquark model. The resulting corrections to both sum rules turn out to be negligible. (author). 23 refs.; Contribution to the Diquark III Conference, Torino, Italy.

  11. On Signatures of Twisted Magnetic Flux Tube Emergence

    CERN Document Server

    Dominguez, Santiago Vargas; Green, Lucie; van Driel-Gesztelyi, Lidia; Hood, Alan

    2011-01-01

    Recent studies of NOAA active region 10953, by Okamoto {\\it et al.} ({\\it Astrophys. J. Lett.} {\\bf 673}, 215, 2008; {\\it Astrophys. J.} {\\bf 697}, 913, 2009), have interpreted photospheric observations of changing widths of the polarities and reversal of the horizontal magnetic field component as signatures of the emergence of a twisted flux tube within the active region and along its internal polarity inversion line (PIL). A filament is observed along the PIL and the active region is assumed to have an arcade structure. To investigate this scenario, MacTaggart and Hood ({\\it Astrophys. J. Lett.} {\\bf 716}, 219, 2010) constructed a dynamic flux emergence model of a twisted cylinder emerging into an overlying arcade. The photospheric signatures observed by Okamoto {\\it et al.} (2008, 2009) are present in the model although their underlying physical mechanisms differ. The model also produces two additional signatures that can be verified by the observations. The first is an increase in the unsigned magnetic fl...

  12. Twisted optical metamaterials for planarized ultrathin broadband circular polarizers.

    Science.gov (United States)

    Zhao, Y; Belkin, M A; Alù, A

    2012-05-29

    Optical metamaterials are usually based on planarized, complex-shaped, resonant nano-inclusions. Three-dimensional geometries may provide a wider set of functionalities, including broadband chirality to manipulate circular polarization at the nanoscale, but their fabrication becomes challenging as their dimensions get smaller. Here we introduce a new paradigm for the realization of optical metamaterials, showing that three-dimensional effects may be obtained without complicated inclusions, but instead by tailoring the relative orientation within the lattice. We apply this concept to realize planarized, broadband bianisotropic metamaterials as stacked nanorod arrays with a tailored rotational twist. Because of the coupling among closely spaced twisted plasmonic metasurfaces, metamaterials realized with conventional lithography may effectively operate as three-dimensional helical structures with broadband bianisotropic optical response. The proposed concept is also shown to relax alignment requirements common in three-dimensional metamaterial designs. The realized sample constitutes an ultrathin, broadband circular polarizer that may be directly integrated within nanophotonic systems.

  13. Twist-three at five loops, Bethe Ansatz and wrapping

    CERN Document Server

    Beccaria, M; Lukowski, T; Zieme, S

    2009-01-01

    We present a formula for the five-loop anomalous dimension of N=4 SYM twist-three operators in the sl(2) sector. We obtain its asymptotic part from the Bethe Ansatz and finite volume corrections from the generalized Luescher formalism, considering scattering processes of spin chain magnons with virtual particles that travel along the cylinder. The complete result respects the expected large spin scaling properties and passes non-trivial tests including reciprocity constraints. We analyze the pole structure and find agreement with a conjectured resummation formula. In analogy with the twist-two anomalous dimension at four-loops, wrapping effects are of order log^2 M/M^2 for large values of the spin.

  14. Microwave modulation characteristics of twisted liquid crystals with chiral dopant

    Directory of Open Access Journals (Sweden)

    Rui Yuan

    2017-01-01

    Full Text Available Adding a chiral dopant in twisted nematic (TN liquid crystal cell can stabilize the orientation of liquid crystal molecules, particularly in high TN (HTN or super TN (STN liquid crystal cells. The difference in pitches in liquid crystal is induced by the chiral dopant, and these different pitches affect the orientation of liquid crystal director under an external applied voltage and influence the characteristics of microwave modulation. To illustrate this point, the microwave phase shift per unit length (MPSL versus voltage is calculated on the basis of the elastic theory of liquid crystal and the finite-difference iterative method. Enhancing the pitch induced by the chiral dopant in liquid crystal increases the MPSLs, but the stability of the twisted structures is decreased. Thus, appropriate pitches of 100d, 4d, and 2d can be applied in TN, HTN, and STN cells with cell gap d to enhance the characteristics of microwave modulation and stabilize the structures in twisted cell. This method can improve the characteristics of liquid crystal microwave modulators such that the operating voltage and the size of such phase shifters can be decreased.

  15. Envelope glycoprotein of arenaviruses.

    Science.gov (United States)

    Burri, Dominique J; da Palma, Joel Ramos; Kunz, Stefan; Pasquato, Antonella

    2012-10-17

    Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for the development of efficacious therapeutics an urgent need. Arenaviruses are comprised of two RNA genome segments and four proteins, the polymerase L, the envelope glycoprotein GP, the matrix protein Z, and the nucleoprotein NP. A crucial step in the arenavirus life-cycle is the biosynthesis and maturation of the GP precursor (GPC) by cellular signal peptidases and the cellular enzyme Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) yielding a tripartite mature GP complex formed by GP1/GP2 and a stable signal peptide (SSP). GPC cleavage by SKI-1/S1P is crucial for fusion competence and incorporation of mature GP into nascent budding virion particles. In a first part of our review, we cover basic aspects and newer developments in the biosynthesis of arenavirus GP and its molecular interaction with SKI-1/S1P. A second part will then highlight the potential of SKI-1/S1P-mediated processing of arenavirus GPC as a novel target for therapeutic intervention to combat human pathogenic arenaviruses.

  16. Envelope Glycoprotein of Arenaviruses

    Directory of Open Access Journals (Sweden)

    Antonella Pasquato

    2012-10-01

    Full Text Available Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for the development of efficacious therapeutics an urgent need. Arenaviruses are comprised of two RNA genome segments and four proteins, the polymerase L, the envelope glycoprotein GP, the matrix protein Z, and the nucleoprotein NP. A crucial step in the arenavirus life-cycle is the biosynthesis and maturation of the GP precursor (GPC by cellular signal peptidases and the cellular enzyme Subtilisin Kexin Isozyme-1 (SKI-1/Site-1 Protease (S1P yielding a tripartite mature GP complex formed by GP1/GP2 and a stable signal peptide (SSP. GPC cleavage by SKI-1/S1P is crucial for fusion competence and incorporation of mature GP into nascent budding virion particles. In a first part of our review, we cover basic aspects and newer developments in the biosynthesis of arenavirus GP and its molecular interaction with SKI-1/S1P. A second part will then highlight the potential of SKI-1/S1P-mediated processing of arenavirus GPC as a novel target for therapeutic intervention to combat human pathogenic arenaviruses.

  17. Multifamily Envelope Leakage Model

    Energy Technology Data Exchange (ETDEWEB)

    Faakye, Omari [Consortium for Advanced Residential Buildings, Norwalk, CT (United States); Griffiths, Dianne [Consortium for Advanced Residential Buildings, Norwalk, CT (United States)

    2015-05-08

    “The cost for blower testing is high, because it is labor intensive, and it may disrupt occupants in multiple units. This high cost and disruption deter program participants, and dissuade them from pursuing energy improvements that would trigger air leakage testing, such as improvements to the building envelope.” This statement found in a 2012 report by Heschong Mahone Group for several California interests emphasizes the importance of reducing the cost and complexity of blower testing in multifamily buildings. Energy efficiency opportunities are being bypassed. The cost of single blower testing is on the order of $300. The cost for guarded blower door testing—the more appropriate test for assessing energy savings opportunities—could easily be six times that, and that’s only if you have the equipment and simultaneous access to multiple apartments. Thus, the proper test is simply not performed. This research seeks to provide an algorithm for predicting the guarded blower door test result based upon a single, total blower door test.

  18. Topological hypermultiplet on N=2 twisted superspace in four dimensions

    CERN Document Server

    Kato, J; Kato, Junji; Miyake, Akiko

    2005-01-01

    We propose a N=2 twisted superspace formalism with a central charge in four dimensions by introducing a Dirac-K\\"ahler twist. Using this formalism, we construct a twisted hypermultiplet action and find an explicit form of fermionic scalar, vector and tensor transformations. We construct a off-shell Donaldson-Witten theory coupled to the twisted hypermultiplet. We show that this action possesses N=4 twisted supersymmetry at on-shell level. It turns out that four-dimensional Dirac-K\\"ahler twist is equivalent to the Marcus's twist.

  19. Transmission properties of cryogenic twisted pair filters

    Energy Technology Data Exchange (ETDEWEB)

    Song, Woon; Rehman, Mushtaq; Chong, Yonuk [Korea Research Institute of Standards and Science, Daejeon (Korea, Republic of); Ryu, Sangwan [Chonnam National University, Gwangju (Korea, Republic of)

    2010-12-15

    We fabricated a cryogenic low pass filter that consists of twisted pairs of manganin wires wrapped in copper tape and measured its transmission characteristics at frequencies up to 18 GHz. The dependence of the microwave transmission characteristics on the filter length was studied, which showed that a filter of length 1.0 m had a 70-dB attenuation at 1 GHz. We also studied the dependence of common- and differential-mode transmission on the number of twists per unit length and found that the number of twists per unit length affects differential-mode transmission but not common-mode transmission. Because the shielded twisted pair filter is more compact than a conventional copper powder filter, it can solve the space and thermal load issues when many cables are required for precision electronic transport experiments at low temperatures.

  20. Mutations in the human TWIST gene.

    Science.gov (United States)

    Gripp, K W; Zackai, E H; Stolle, C A

    2000-01-01

    Saethre-Chotzen syndrome is a relatively common craniosynostosis disorder with autosomal dominant inheritance. Mutations in the TWIST gene have been identified in patients with Saethre-Chotzen syndrome. The TWIST gene product is a transcription factor with DNA binding and helix-loop-helix domains. Numerous missense and nonsense mutations cluster in the functional domains, without any apparent mutational hot spot. Two novel point mutations and one novel polymorphism are included in this review. Large deletions including the TWIST gene have been identified in some patients with learning disabilities or mental retardation, which are not typically part of the Saethre-Chotzen syndrome. Comprehensive studies in patients with the clinical diagnosis of Saethre-Chotzen syndrome have demonstrated a TWIST gene abnormality in about 80%, up to 37% of which may be large deletions [Johnson et al., 1998]. The gene deletions and numerous nonsense mutations are suggestive of haploinsufficiency as the disease-causing mechanism. No genotype phenotype correlation was apparent.

  1. Observation of subluminal twisted light in vacuum

    CERN Document Server

    Bouchard, Frédéric; Mand, Harjaspreet; Boyd, Robert W; Karimi, Ebrahim

    2015-01-01

    Einstein's theory of relativity establishes the speed of light in vacuum, c, as a fundamental constant. However, the speed of light pulses can be altered significantly in dispersive materials. While significant control can be exerted over the speed of light in such media, no experimental demonstration of altered light speeds has hitherto been achieved in vacuum for ``twisted'' optical beams. We show that ``twisted'' light pulses exhibit subluminal velocities in vacuum, being slowed by 0.1\\% relative to c. This work does not challenge relativity theory, but experimentally supports a body of theoretical work on the counterintuitive vacuum group velocities of twisted pulses. These results are particularly important given recent interest in applications of twisted light to quantum information, communication and quantum key distribution.

  2. Twisted Vector Bundles on Pointed Nodal Curves

    Indian Academy of Sciences (India)

    Ivan Kausz

    2005-05-01

    Motivated by the quest for a good compactification of the moduli space of -bundles on a nodal curve we establish a striking relationship between Abramovich’s and Vistoli’s twisted bundles and Gieseker vector bundles.

  3. Gerbes and twisted orbifold quantum cohomology

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper,we construct an orbifold quantum cohomology twisted by a flat gerbe. Then we compute these invariants in the case of a smooth manifold and a discrete torsion on a global quotient orbifold.

  4. Gerbes and twisted orbifold quantum cohomology

    Institute of Scientific and Technical Information of China (English)

    PAN JianZhong; RUAN YongBin; YIN XiaoQin

    2008-01-01

    In this paper, we construct an orbifold quantum cohomology twisted by a flat gerbe.Then we compute these invariants in the case of a smooth manifold and a discrete torsion on a global quotient orbifold.

  5. Genomic pathways modulated by Twist in breast cancer

    OpenAIRE

    Vesuna, Farhad; Bergman, Yehudit; Raman, Venu

    2017-01-01

    Background The basic helix-loop-helix transcription factor TWIST1 (Twist) is involved in embryonic cell lineage determination and mesodermal differentiation. There is evidence to indicate that Twist expression plays a role in breast tumor formation and metastasis, but the role of Twist in dysregulating pathways that drive the metastatic cascade is unclear. Moreover, many of the genes and pathways dysregulated by Twist in cell lines and mouse models have not been validated against data obtaine...

  6. DDalphaAMG for Twisted Mass Fermions

    CERN Document Server

    Bacchio, Simone; Finkenrath, Jacob; Frommer, Andreas; Kahl, Karsten; Rottmann, Matthias

    2016-01-01

    We present the Adaptive Aggregation-based Domain Decomposition Multigrid method extended to the twisted mass fermion discretization action. We show comparisons of results as a function of tuning the parameters that enter the twisted mass version of the DDalphaAMG library (https://github.com/sbacchio/DDalphaAMG). Moreover, we linked the DDalphaAMG library to the tmLQCD software package and give details on the performance of the multigrid solver during HMC simulations at the physical point.

  7. Twisted Covariant Noncommutative Self-dual Gravity

    CERN Document Server

    Estrada-Jimenez, S; Obregón, O; Ramírez, C

    2008-01-01

    A twisted covariant formulation of noncommutative self-dual gravity is presented. The recent formulation introduced by J. Wess and coworkers for constructing twisted Yang-Mills fields is used. It is shown that the noncommutative torsion is solved at any order of the $\\theta$-expansion in terms of the tetrad and the extra fields of the theory. In the process the first order expansion in $\\theta$ for the Pleba\\'nski action is explicitly obtained.

  8. OAM mode converter in twisted fibers

    DEFF Research Database (Denmark)

    Usuga Castaneda, Mario A.; Beltran-Mejia, Felipe; Cordeiro, Cristiano

    2014-01-01

    We analyze the case of an OAM mode converter based on a twisted fiber, through finite element simulations where we exploit an equivalence between geometric and material transformations. The obtained converter has potential applications in MDM. © 2014 OSA.......We analyze the case of an OAM mode converter based on a twisted fiber, through finite element simulations where we exploit an equivalence between geometric and material transformations. The obtained converter has potential applications in MDM. © 2014 OSA....

  9. On Supermultiplet Twisting and Spin-Statistics

    CERN Document Server

    Hubsch, Tristan

    2012-01-01

    Twisting of off-shell supermultiplets in models with 1+1-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this type of twisting, if nontrivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets.

  10. On Supermultiplet Twisting and Spin-Statistics

    OpenAIRE

    Hubsch, Tristan

    2012-01-01

    Twisting of off-shell supermultiplets in models with 1+1-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this off-shell supermultiplet twisting, if non-trivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets. This feature is shown to be ubiquitous in all...

  11. The gradient flow in a twisted box

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Alberto [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann-Inst. fuer Computing NIC

    2013-08-15

    We study the perturbative behavior of the gradient flow in a twisted box. We apply this information to define a running coupling using the energy density of the flow field. We study the step-scaling function and the size of cutoff effects in SU(2) pure gauge theory. We conclude that the twisted gradient flow running coupling scheme is a valid strategy for step-scaling purposes due to the relatively mild cutoff effects and high precision.

  12. Twisted Boundary Conditions in Lattice Simulations

    CERN Document Server

    Sachrajda, Christopher T C

    2004-01-01

    By imposing twisted boundary conditions on quark fields it is possible to access components of momenta other than integer multiples of 2pi/L on a lattice with spatial volume L^3. We use Chiral Perturbation Theory to study finite-volume effects with twisted boundary conditions for quantities without final-state interactions, such as meson masses, decay constants and semileptonic form factors, and confirm that they remain exponentially small with the volume. We show that this is also the case for "partially twisted" boundary conditions, in which (some of) the valence quarks satisfy twisted boundary conditions but the sea quarks satisfy periodic boundary conditions. This observation implies that it is not necessary to generate new gluon configurations for every choice of the twist angle, making the method much more practicable. For K->pipi decays we show that the breaking of isospin symmetry by the twisted boundary conditions implies that the amplitudes cannot be determined in general (on this point we disagree ...

  13. Discrete optimization in architecture building envelope

    CERN Document Server

    Zawidzki, Machi

    2017-01-01

    This book explores the extremely modular systems that meet two criteria: they allow the creation of structurally sound free-form structures, and they are comprised of as few types of modules as possible. Divided into two parts, it presents Pipe-Z (PZ) and Truss-Z (TZ) systems. PZ is more fundamental and forms spatial mathematical knots by assembling one type of unit (PZM). The shape of PZ is controlled by relative twists of a sequence of congruent PZMs. TZ is a skeletal system for creating free-form pedestrian ramps and ramp networks among any number of terminals in space. TZ structures are composed of four variations of a single basic unit subjected to affine transformations (mirror reflection, rotation and combination of both). .

  14. Development of High Specific Strength Envelope Materials

    Science.gov (United States)

    Komatsu, Keiji; Sano, Masa-Aki; Kakuta, Yoshiaki

    Progress in materials technology has produced a much more durable synthetic fabric envelope for the non-rigid airship. Flexible materials are required to form airship envelopes, ballonets, load curtains, gas bags and covering rigid structures. Polybenzoxazole fiber (Zylon) and polyalirate fiber (Vectran) show high specific tensile strength, so that we developed membrane using these high specific tensile strength fibers as a load carrier. The main material developed is a Zylon or Vectran load carrier sealed internally with a polyurethane bonded inner gas retention film (EVOH). The external surface provides weather protecting with, for instance, a titanium oxide integrated polyurethane or Tedlar film. The mechanical test results show that tensile strength 1,000 N/cm is attained with weight less than 230g/m2. In addition to the mechanical properties, temperature dependence of the joint strength and solar absorptivity and emissivity of the surface are measured. 

  15. The LHC on an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays ...

  16. The LHC in an envelope

    CERN Multimedia

    2007-01-01

    The series of envelopes featuring CERN issued this summer was a huge success. The French postal services of the Pays de Gex will shortly be launching the second set of pre-paid envelopes issued in collaboration with the Laboratory this year, this time highlighting the LHC. Five thousand envelopes describing the accelerator’s capabilities will go on sale on 12 November, and some of the packs will even contain a small sample of the cables from the heart of the LHC magnets. The sets of ten pre-paid envelopes will tell you everything about CERN’s flagship accelerator, from its astounding technical capabilities to its spin-offs in the fields of technology and human resources. Each envelope will feature a different attribute or spin-off of the LHC. People will be invited to consult CERN’s public website for more detailed explanations if they want to know more. The new envelopes will be available from five post offices in the Pays de Gex (Ferney-Voltaire, Prévessin...

  17. Report on twisted nematic and supertwisted nematic device characterization program

    Science.gov (United States)

    1995-01-01

    In this study we measured the optical characteristics of normally white twisted nematic (NWTN) and super twisted nematic (STN ) cells. Though no dynamic computer model was available, the static observations were compared with computer simulated behavior. The measurements were taken as a function of both viewing angle and applied voltage and included in the static case not only luminance but also contrast ratio and chromaticity . We employed the computer model Twist Cell Optics, developed at Kent State in conjunction with this study, and whose optical modeling foundation, Iike the ViDEOS program, is the 4 x 4 matrix method of Berreman. In order to resolve discrepancies between the experimental and modeled data the optical parameters of the individual cell components, where not known, were determined using refractometry, profilometry, and various forms of ellipsometry. The resulting agreement between experiment and model is quite good due primarily to a better understanding of the structure and optics of dichroic sheet polarizers. A description of the model and test cells employed are given in section 2. Section 3 contains the experimental data gathered and section 4 gives examples of the fit between model and experiment. Also included with this report are a pair of papers which resulted from the research and which detail the polarizer properties and some of the cell characterization methods.

  18. Distribution of ferromagnetic moments in crystals under external twisting

    Energy Technology Data Exchange (ETDEWEB)

    Zavorotnev, Yu.D., E-mail: zavorotnev.yurii@gmail.com [Donetsk Institute for Physics and Engineering, NAS of Ukraine, 72 R.Luxemburg Street, 83114 Donetsk (Ukraine); Pashinskaya, E.H.; Varyukhin, V.N. [Donetsk Institute for Physics and Engineering, NAS of Ukraine, 72 R.Luxemburg Street, 83114 Donetsk (Ukraine); Popova, O.Yu. [Donetsk National Technical University, 58 Artema Street, 83001 Donetsk (Ukraine)

    2014-01-15

    In an easy-axis ferromagnet, the effect of superposition of severe plastic deformation by twisting (SPDT) perpendicular to the “easy axis” on the ferromagnetic order parameter (OP) distribution is studied. The consideration is carried out within the frameworks of phenomenological theory of Landau. It is shown that SPDT effects the results in occurrence of the normal component of the magnetic OP and periodical change of OP modulus. The law of distribution of the magnetic moment is determined by proximity of the temperature of the crystal and any phase transition. - Highlights: • The effect of application of external twisting deformation to a ferromagnetic crystal of easy-axis type is studied theoretically. • The deformation axis is directed normally to the easy axis of the crystal. • The consideration is carried out within the frameworks of a phenomenological model. • It is shown that in this case, a spiral long-period structure is formed. • Besides, spatial distribution of the modulus of ferromagnetic vector changes depending on the temperature and the twisting moment.

  19. Unwinding motion of a twisted active region filament

    Energy Technology Data Exchange (ETDEWEB)

    Yan, X. L.; Xue, Z. K.; Kong, D. F. [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Liu, J. H. [Department of Physics, Shijiazhuang University, Shijiazhuang 050035 (China); Xu, C. L. [Yunnan Normal University, Kunming 650092 (China)

    2014-12-10

    To better understand the structures of active region filaments and the eruption process, we study an active region filament eruption in active region NOAA 11082 in detail on 2010 June 22. Before the filament eruption, the opposite unidirectional material flows appeared in succession along the spine of the filament. The rising of the filament triggered two B-class flares at the upper part of the filament. As the bright material was injected into the filament from the sites of the flares, the filament exhibited a rapid uplift accompanying the counterclockwise rotation of the filament body. From the expansion of the filament, we can see that the filament consisted of twisted magnetic field lines. The total twist of the filament is at least 5π obtained by using a time slice method. According to the morphology change during the filament eruption, it is found that the active region filament was a twisted flux rope and its unwinding motion was like a solar tornado. We also find that there was a continuous magnetic helicity injection before and during the filament eruption. It is confirmed that magnetic helicity can be transferred from the photosphere to the filament. Using the extrapolated potential fields, the average decay index of the background magnetic fields over the filament is 0.91. Consequently, these findings imply that the mechanism of solar filament eruption could be due to the kink instability and magnetic helicity accumulation.

  20. Unwinding motion of a twisted active-region filament

    CERN Document Server

    Yan, X L; Liu, J H; Kong, D F; Xu, C L

    2014-01-01

    To better understand the structures of active-region filaments and the eruption process, we study an active-region filament eruption in active region NOAA 11082 in detail on June 22, 2010. Before the filament eruption, the opposite unidirectional material flows appeared in succession along the spine of the filament. The rising of the filament triggered two B-class flares at the upper part of the filament. As the bright material was injected into the filament from the sites of the flares, the filament exhibited a rapid uplift accompanying the counterclockwise rotation of the filament body. From the expansion of the filament, we can see that the filament is consisted of twisted magnetic field lines. The total twist of the filament is at least 5$\\pi$ obtained by using time slice method. According to the morphology change during the filament eruption, it is found that the active-region filament was a twisted flux rope and its unwinding motion was like a solar tornado. We also find that there was a continuous magn...

  1. Unwinding Motion of a Twisted Active Region Filament

    Science.gov (United States)

    Yan, X. L.; Xue, Z. K.; Liu, J. H.; Kong, D. F.; Xu, C. L.

    2014-12-01

    To better understand the structures of active region filaments and the eruption process, we study an active region filament eruption in active region NOAA 11082 in detail on 2010 June 22. Before the filament eruption, the opposite unidirectional material flows appeared in succession along the spine of the filament. The rising of the filament triggered two B-class flares at the upper part of the filament. As the bright material was injected into the filament from the sites of the flares, the filament exhibited a rapid uplift accompanying the counterclockwise rotation of the filament body. From the expansion of the filament, we can see that the filament consisted of twisted magnetic field lines. The total twist of the filament is at least 5π obtained by using a time slice method. According to the morphology change during the filament eruption, it is found that the active region filament was a twisted flux rope and its unwinding motion was like a solar tornado. We also find that there was a continuous magnetic helicity injection before and during the filament eruption. It is confirmed that magnetic helicity can be transferred from the photosphere to the filament. Using the extrapolated potential fields, the average decay index of the background magnetic fields over the filament is 0.91. Consequently, these findings imply that the mechanism of solar filament eruption could be due to the kink instability and magnetic helicity accumulation.

  2. Valence-bond non-equilibrium solvation model for a twisting monomethine cyanine

    Science.gov (United States)

    McConnell, Sean; McKenzie, Ross H.; Olsen, Seth

    2015-02-01

    We propose and analyze a two-state valence-bond model of non-equilibrium solvation effects on the excited-state twisting reaction of monomethine cyanines. Suppression of this reaction is thought responsible for environment-dependent fluorescence yield enhancement in these dyes. Fluorescence is quenched because twisting is accompanied via the formation of dark twisted intramolecular charge-transfer (TICT) states. For monomethine cyanines, where the ground state is a superposition of structures with different bond and charge localizations, there are two possible twisting pathways with different charge localizations in the excited state. For parameters corresponding to symmetric monomethines, the model predicts two low-energy twisting channels on the excited-state surface, which leads to a manifold of TICT states. For typical monomethines, twisting on the excited state surface will occur with a small barrier or no barrier. Changes in the solvation configuration can differentially stabilize TICT states in channels corresponding to different bonds, and that the position of a conical intersection between adiabatic states moves in response to solvation to stabilize either one channel or the other. There is a conical intersection seam that grows along the bottom of the excited-state potential with increasing solvent polarity. For monomethine cyanines with modest-sized terminal groups in moderately polar solution, the bottom of the excited-state potential surface is completely spanned by a conical intersection seam.

  3. DNA packaging in bacteriophage: is twist important?

    Science.gov (United States)

    Spakowitz, Andrew James; Wang, Zhen-Gang

    2005-06-01

    We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with rotation exhibits a spool-like character that is consistent with experimental and previous theoretical work, whereas feeding without rotation results in a folded conformation inconsistent with a spool conformation. The chain segment density shows a layered structure, which is more pronounced for packaging with rotation. However, in both cases, the conformation is marked by frequent jumps of the polymer chain from layer to layer, potentially influencing the ability to disentangle during subsequent ejection. Ejection simulations with and without Brownian forces show that Brownian forces are necessary to achieve complete ejection of the polymer chain in the absence of external forces.

  4. First principles study and empirical parametrization of twisted bilayer MoS2 based on band-unfolding

    CERN Document Server

    Tan, Yaohua; Ghosh, Avik

    2016-01-01

    We explore the band structure and ballistic electron transport in twisted bilayer $\\textrm{MoS}_2$ using Density Functional Theory (DFT). The sphagetti like bands are unfolded to generate band structures in the primitive unit cell of the original un-twisted $\\textrm{MoS}_2$ bilayer and projected onto an individual layer. The corresponding twist angle dependent indirect bandedges are extracted from the unfolded band structures. Based on a comparison within the same primitive unit cell, an efficient two band effective mass model for indirect conduction and valence valleys is created and parameterized by fitting the unfolded band structures. With the two band effective mass model, transport properties - specifically, we calculate the ballistic transmission in arbitrarily twisted bilayer $\\textrm{MoS}_2$.

  5. Soft tissue twisting injuries of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Magee, T.; Shapiro, M. [Neuroimaging Inst., Melbourne, FL (United States)

    2001-08-01

    Twisting injuries occur as a result of differential motion of different tissue types in injuries with some rotational force. These injuries are well described in brain injuries but, to our knowledge, have not been described in the musculoskeletal literature. We correlated the clinical examination and MR findings of 20 patients with twisting injuries of the soft tissues around the knee. Design and patients: We prospectively followed the clinical courses of 20 patients with knee injuries who had clinical histories and MR findings to suggest twisting injuries of the subcutaneous tissues. Patients with associated internal derangement of the knee (i.e., meniscal tears, ligamentous or bone injuries) were excluded from this study. MR findings to suggest twisting injuries included linear areas of abnormal dark signal on T1-weighted sequences and abnormal bright signal on T2-weighted or short tau inversion recovery (STIR) sequences and/or signal to suggest hemorrhage within the subcutaneous tissues. These MR criteria were adapted from those established for indirect musculotendinous junction injuries. Results: All 20 patients presented with considerable pain that suggested internal derangement on physical examination by the referring orthopedic surgeons. All presented with injuries associated with rotational force. The patients were placed on a course of protected weight-bearing of the affected extremity for 4 weeks. All patients had pain relief by clinical examination after this period of protected weight-bearing. Twisting injuries of the soft tissues can result in considerable pain that can be confused with internal derangement of the knee on physical examination. Soft tissue twisting injuries need to be recognized on MR examinations as they may be the cause of the patient's pain despite no MR evidence of internal derangement of the knee. The demonstration of soft tissue twisting injuries in a patient with severe knee pain but no documented internal derangement on MR

  6. Polarimetry and the Envelopes of Magellanic B[e] Supergiants

    CERN Document Server

    Magalhães, A M; Melgarejo, R; Pereyra, A

    2006-01-01

    We discuss the nature of the circumstellar envelopes around the B[e] supergiants (B[e]SG) in the Magellanic Clouds (MC). Contrary to those in the Galaxy, the MC B[e]SG have a well defined luminosity and can be considered members of a well defined class. We discuss spectroscopy and optical broadband polarimetry and spectropolarimetry data. These data show for the first time detailed changes in the polarization across several spectral features. We show that the envelopes of the B[e]SG are generally variable. Broadband polarimetry data show that the envelopes are definitely non-spherically symmetric and large non-axisymmetric ejections may occur. In addition to that, spectropolarimetry is coming of age as a tool to study the B[e]SG envelope structure.

  7. Crystal structure of pseudoguainolide

    Directory of Open Access Journals (Sweden)

    Noureddine Beghidja

    2015-03-01

    Full Text Available The lactone ring in the title molecule, C15H22O3 (systematic name: 3,4a,8-trimethyldodecahydroazuleno[6,5-b]furan-2,5-dione, assumes an envelope conformation with the methine C atom adjacent to the the methine C atom carrying the methyl substituent being the flap atom. The other five-membered ring adopts a twisted conformation with the twist being about the methine–methylene C—C bond. The seven-membered ring is based on a twisted boat conformation. No specific interactions are noted in the the crystal packing.

  8. Integral Twist Actuation of Helicopter Rotor Blades for Vibration Reduction

    Science.gov (United States)

    Shin, SangJoon; Cesnik, Carlos E. S.

    2001-01-01

    Active integral twist control for vibration reduction of helicopter rotors during forward flight is investigated. The twist deformation is obtained using embedded anisotropic piezocomposite actuators. An analytical framework is developed to examine integrally-twisted blades and their aeroelastic response during different flight conditions: frequency domain analysis for hover, and time domain analysis for forward flight. Both stem from the same three-dimensional electroelastic beam formulation with geometrical-exactness, and axe coupled with a finite-state dynamic inflow aerodynamics model. A prototype Active Twist Rotor blade was designed with this framework using Active Fiber Composites as the actuator. The ATR prototype blade was successfully tested under non-rotating conditions. Hover testing was conducted to evaluate structural integrity and dynamic response. In both conditions, a very good correlation was obtained against the analysis. Finally, a four-bladed ATR system is built and tested to demonstrate its concept in forward flight. This experiment was conducted at NASA Langley Tansonic Dynamics Tunnel and represents the first-of-a-kind Mach-scaled fully-active-twist rotor system to undergo forward flight test. In parallel, the impact upon the fixed- and rotating-system loads is estimated by the analysis. While discrepancies are found in the amplitude of the loads under actuation, the predicted trend of load variation with respect to its control phase correlates well. It was also shown, both experimentally and numerically, that the ATR blade design has the potential for hub vibratory load reduction of up to 90% using individual blade control actuation. Using the numerical framework, system identification is performed to estimate the harmonic transfer functions. The linear time-periodic system can be represented by a linear time-invariant system under the three modes of blade actuation: collective, longitudinal cyclic, and lateral cyclic. A vibration

  9. Parasitic Events in Envelope Analysis

    Directory of Open Access Journals (Sweden)

    J. Doubek

    2001-01-01

    Full Text Available Envelope analysis allows fast fault location of individual gearboxes and parts of bearings by repetition frequency determination of the mechanical catch of an amplitude-modulated signal. Systematic faults arise when using envelope analysis on a signal with strong changes. The source of these events is the range of function definition of used in convolution integral definition. This integral is used for Hilbert image calculation of analyzed signal. Overshoots (almost similar to Gibbs events on a synthetic signal using the Fourier series are result from these faults. Overshoots are caused by parasitic spectral lines in the frequency domain, which can produce faulty diagnostic analysis.This paper describes systematic arising during faults rising by signal numerical calculation using envelope analysis with Hilbert transform. It goes on to offer a mathematical analysis of these systematic faults.

  10. Exotic twisted equivariant cohomology of loop spaces,twisted Bismut-Chern character and T-duality

    CERN Document Server

    Han, Fei

    2014-01-01

    We define completed periodic {\\em exotic twisted $\\mathbb{T}$-equivariant cohomology} for loop spaces of smooth manifolds. We then show that the twisted Bismut-Chern character, defined on the twisted K-theory of the smooth manifold, twisted by a gerbe with connection, takes values in the completed periodic exotic twisted $\\mathbb{T}$-equivariant cohomology of the loop space of the smooth manifold. We establish a localisation theorem for the completed periodic exotic twisted $\\mathbb{T}$-equivariant cohomology for loop spaces and apply it to establish T-duality in a background flux in type II String Theory from a loop space perspective.

  11. Analysis of gun barrel rifling twist

    Science.gov (United States)

    Sun, Jia; Chen, Guangsong; Qian, Linfang; Liu, Taisu

    2017-05-01

    Aiming at the problem of gun barrel rifling twist, the constraint relation between rifling and projectile is investigated. The constraint model of rifling and projectile is established and the geometric relation between the twist and the motion of projectile is analyzed. Based on the constraint model, according to the rotating band that is fired, the stress and the motion law of the rotating band in bore are analyzed. The effects to rotating band (double rotating band or wide driving band) caused by different rifling (rib rifling, increasing rifling and combined rifling) are also investigated. The model is demonstrated by several examples. The results of numerical examples and the constraint mode show that the uncertainty factors will be brought in the increasing rifling and combined rifling during the projectile move in the bore. According to the amplitude and the strength of the twist acting on rotating band, the steady property of rotational motion of the projectile, the rib rifling is a better choose.

  12. Blind analysis results of the TWIST experiment

    CERN Document Server

    Hillairet, A; Bueno, J F; Davydov, Y I; Depommier, P; Faszer, W; Fujiwara, M C; Gagliardi, C A; Gaponenko, A; Grossheim, A; Gill, D R; Gumplinger, P; Hasinoff, M D; Henderson, R S; Hu, J; Koetke, D D; MacDonald, R P; Marshall, G M; Mathie, E W; Mischke, R E; Olchanski, K; Olin, A; Openshaw, R; Poutissou, J -M; Poutissou, R; Selivanov, V; Sheffer, G; Shin, B; Stanislaus, T D S; Tacik, R; Tribble, R E

    2010-01-01

    The TRIUMF Weak Interaction Symmetry Test (TWIST) experiment was designed to test the standard model at high precision in the purely leptonic decay of polarized muons. A general four-fermion interaction model is used to describe the muon decay. TWIST measures three of the four muon decay parameters of this model, $\\rho$, $\\delta$ and $P_{\\mu}^{\\pi} \\xi$, from the shape of the momentum-angle spectrum. The results of this model independent approach are compared to the standard model predictions and used to constrain new physics. Our collaboration has finalized the blind analysis of the final experimental data taken in 2006 and 2007. This analysis mostly reached our goal of a precision of an order of magnitude improvement over the pre-TWIST measurements.

  13. Dynamical Twisted Mass Fermions with Light Quarks

    CERN Document Server

    Boucaud, P; Farchioni, F; Frezzotti, R; Giménez, V; Herdoiza, G; Jansen, K; Lubicz, V; Martinelli, G; McNeile, C; Michael, C; Montvay, I; Palao, D; Papinutto, Mauro; Pickavance, J; Rossi, G C; Scorzato, L; Shindler, A; Simula, S; Urbach, C; Wenger, U; Boucaud, Ph.

    2007-01-01

    We present results of dynamical simulations with 2 flavours of degenerate Wilson twisted mass quarks at maximal twist in the range of pseudo scalar masses from 300 to 550 MeV. The simulations are performed at one value of the lattice spacing a \\lesssim 0.1 fm. In order to have O(a) improvement and aiming at small residual cutoff effects, the theory is tuned to maximal twist by requiring the vanishing of the untwisted quark mass. Precise results for the pseudo scalar decay constant and the pseudo scalar mass are confronted with chiral perturbation theory predictions and the low energy constants F, \\bar{l}_3 and \\bar{l}_4 are evaluated with small statistical errors.

  14. On reweighting for twisted boundary conditions

    CERN Document Server

    Bussone, Andrea; Hansen, Martin; Pica, Claudio

    2016-01-01

    We consider the possibility of using reweighting techniques in order to correct for the breaking of unitarity when twisted boundary conditions are imposed on valence fermions in simulations of lattice gauge theories. We start by studying the properties of reweighting factors and their variances at tree-level. That leads us to the introduction of a factorization for the fermionic reweighting determinant. In the numerical, stochastic, implementation of the method, we find that the effect of reweighting is negligible in the case of large volumes but it is sizeable when the volumes are small and the twisting angles are large. More importantly, we find that for un-improved Wilson fermions, and in small volumes, the dependence of the critical quark mass on the twisting angle is quite pronounced and results in large violations of the continuum dispersion relation.

  15. Derivatives and the Role of the Drinfel'd Twist in Noncommutative String Theory

    CERN Document Server

    Watts, P

    2000-01-01

    We consider the derivatives which appear in the context of noncommutative string theory. First, we identify the correct derivations to use when the underlying structure of the theory is a quasitriangular Hopf algebra. Then we show that this is a specific case of a more general structure utilising the Drinfel'd twist. We go on to present reasons as to why we feel that the low-energy effective action, when written in terms of the original commuting coordinates, should explicitly exhibit this twisting.

  16. Moisture dynamics in building envelopes

    Energy Technology Data Exchange (ETDEWEB)

    Peuhkuri, R.

    2003-07-01

    The overall scope of this Thesis 'Moisture dynamics in building envelopes' has been to characterise how the various porous insulation materials investigated performed hygro thermally under conditions similar to those in a typical building envelope. As a result of the changing temperature and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. (au)

  17. Twisted versus braided magnetic flux ropes in coronal geometry. II. Comparative behaviour

    Science.gov (United States)

    Prior, C.; Yeates, A. R.

    2016-06-01

    Aims: Sigmoidal structures in the solar corona are commonly associated with magnetic flux ropes whose magnetic field lines are twisted about a mutual axis. Their dynamical evolution is well studied, with sufficient twisting leading to large-scale rotation (writhing) and vertical expansion, possibly leading to ejection. Here, we investigate the behaviour of flux ropes whose field lines have more complex entangled/braided configurations. Our hypothesis is that this internal structure will inhibit the large-scale morphological changes. Additionally, we investigate the influence of the background field within which the rope is embedded. Methods: A technique for generating tubular magnetic fields with arbitrary axial geometry and internal structure, introduced in part I of this study, provides the initial conditions for resistive-MHD simulations. The tubular fields are embedded in a linear force-free background, and we consider various internal structures for the tubular field, including both twisted and braided topologies. These embedded flux ropes are then evolved using a 3D MHD code. Results: Firstly, in a background where twisted flux ropes evolve through the expected non-linear writhing and vertical expansion, we find that flux ropes with sufficiently braided/entangled interiors show no such large-scale changes. Secondly, embedding a twisted flux rope in a background field with a sigmoidal inversion line leads to eventual reversal of the large-scale rotation. Thirdly, in some cases a braided flux rope splits due to reconnection into two twisted flux ropes of opposing chirality - a phenomenon previously observed in cylindrical configurations. Conclusions: Sufficiently complex entanglement of the magnetic field lines within a flux rope can suppress large-scale morphological changes of its axis, with magnetic energy reduced instead through reconnection and expansion. The structure of the background magnetic field can significantly affect the changing morphology of a

  18. Local index formula and twisted spectral triples

    CERN Document Server

    Moscovici, Henri

    2009-01-01

    We prove a local index formula for a class of twisted spectral triples of type III modeled on the transverse geometry of conformal foliations with locally constant transverse conformal factor. Compared with the earlier proof of the untwisted case, the novel aspect resides in the fact that the twisted analogues of the JLO entire cocycle and of its retraction are no longer cocycles in their respective Connes bicomplexes. We show however that the passage to the infinite temperature limit, respectively the integration along the full temperature range against the Haar measure of the positive half-line, has the remarkable effect of curing in both cases the deviations from the cocycle identity.

  19. On Supermultiplet Twisting and Spin-Statistics

    Science.gov (United States)

    Hübsch, T.

    2013-10-01

    Twisting of off-shell supermultiplets in models with (1+1)-dimensional spacetime has been discovered in 1984, and was shown to be a generic feature of off-shell representations in worldline supersymmetry two decades later. It is shown herein that in all supersymmetric models with spacetime of four or more dimensions, this off-shell supermultiplet twisting, if nontrivial, necessarily maps regular (non-ghost) supermultiplets to ghost supermultiplets. This feature is shown to be ubiquitous in all fully off-shell supersymmetric models with (BV/BRST-treated) constraints.

  20. Multi-twist optical Mobius strips

    CERN Document Server

    Freund, Isaac

    2009-01-01

    Circularly polarized Gauss-Laguerre GL(0,0) and GL(0,1) laser beams that cross at their waists at a small angle are shown to generate a quasi-paraxial field that contains an axial line of circular polarization, a C line, surrounded by polarization ellipses whose major and minor axes generate multi-twist Mobius strips with twist numbers that increase with distance from the C point. These Mobius strips are interpreted in terms of Berry's phase for parallel transport of the ellipse axes around the C point.

  1. Effects Of Twist On Ceramic Threads

    Science.gov (United States)

    Sawko, Paul M.; Tran, Huy Kim

    1989-01-01

    Report describes study of effects of yarn twist and other manufacturing parameters on strength of ceramic sewing threads. Three types of thread considered; silica, aluminoborosilicate (ABS) with 14 percent boria, and ABS with 2 percent boria. For silica thread, best twist found 300 turns per meter. Produced highest break strength at temperatures up to about 540 degree C. Overall strengths of both ABS threads higher than silica thread. Threads used to stitch insulating blankets for reusable spacraft; must resist high temperatures and high aerodynamic loads of reentry into atmosphere of Earth.

  2. Spectral flows and twisted topological theories

    CERN Document Server

    Gato-Rivera, Beatriz; Gato-Rivera, Beatriz; Rosado, Jose Ignacio

    1995-01-01

    We analyze the action of the spectral flows on N=2 twisted topological theories. We show that they provide a useful mapping between the two twisted topological theories associated to a given N=2 superconformal theory. This mapping can also be viewed as a topological algebra automorphism. In particular null vectors are mapped into null vectors, considerably simplifying their computation. We give the level 2 results. Finally we discuss the spectral flow mapping in the case of the DDK and KM realizations of the topological algebra.

  3. Planet formation with envelope enrichment: new insights on planetary diversity

    CERN Document Server

    Venturini, Julia; Benz, Willy

    2016-01-01

    We compute, for the first time, self-consistent models of planet growth including the effect of envelope enrichment. The change of envelope metallicity is assumed to be the result of planetesimal disruption or icy pebble sublimation. We solve internal structure equations taking into account global energy conservation for the envelope to compute in-situ planetary growth. We consider different opacities and equations of state suited for a wide range of metallicities. We find that envelope enrichment speeds up the formation of gas giants. It also explains naturally the formation of low and intermediate mass objects with large fractions of H-He (~ 20 - 30 % in mass). High opacity models explain well the metallicity of the giant planets of the solar system, whereas low opacity models are suited for forming small mass objects with thick H-He envelopes and gas giants with sub-solar envelope metallicities. We find good agreement between our models and the estimated water abundance for WASP-43b. For HD 189733b, HD 209...

  4. Quantum Nuclear Pasta Calculations with Twisted Angular Boundary Conditions

    Science.gov (United States)

    Schuetrumpf, Bastian; Nazarewicz, Witold

    2015-10-01

    Nuclear pasta, expected to be present in the inner crust of neutron stars and core collapse supernovae, can contain a wide spectrum of different exotic shapes such as nuclear rods and slabs. There are also more complicated, network-like structures, the triply periodic minimal surfaces, already known e.g. in biological systems. These shapes are studied with the Hartree-Fock method using modern Skyrme forces. Furthermore twisted angular boundary conditions are utilized to reduce finite size effects in the rectangular simulation boxes. It is shown, that this improves the accuracy of the calculations drastically and additionally more insights into the mechanism of forming minimal surfaces can be gained.

  5. A Twist-4 Effect in the Parton Evolution Processes

    Institute of Scientific and Technical Information of China (English)

    RUAN Jian-Hong; ZHU Wei; LI Guang-Lie

    2000-01-01

    Recently, a research group reported that they can fit the F2 data well by using the Altarelli-Parisi evolutionequation with a valence-like initial gluon distribution, which means that we need not consider the high twisteffects in the proton. In this letter, we point out that their valence-like initial gluon distribution is unreasonable for the proton structure function. With the reasonable initial distributions, we find that the high twist corrections to the Altarelli-Parisi evolution equation is necessary.

  6. Translucent insulating building envelope

    DEFF Research Database (Denmark)

    Rahbek, Jens Eg

    1997-01-01

    A new type of translucent insulating material has been tested. This material is made of Celulose-Acetat and have a honey-comb structure. The material has a high solar transmittance and is highly insulating. The material is relatively cheap to produce. Danish Title: Translucent isolerende klimaskærm....

  7. Translucent insulating building envelope

    DEFF Research Database (Denmark)

    Rahbek, Jens Eg

    1997-01-01

    A new type of translucent insulating material has been tested. This material is made of Celulose-Acetat and have a honey-comb structure. The material has a high solar transmittance and is highly insulating. The material is relatively cheap to produce. Danish Title: Translucent isolerende klimaskærm....

  8. A non-commuting twist in the partition function

    CERN Document Server

    Govindarajan, Suresh

    2012-01-01

    We compute a twisted index for an orbifold theory when the twist generating group does not commute with the orbifold group. The twisted index requires the theory to be defined on moduli spaces that are compatible with the twist. This is carried out for CHL models at special points in the moduli space where they admit dihedral symmetries. The commutator subgroup of the dihedral groups are cyclic groups that are used to construct the CHL orbifolds. The residual reflection symmetry is chosen to act as a `twist' on the partition function. The reflection symmetries do not commute with the orbifolding group and hence we refer to this as a non-commuting twist. We count the degeneracy of half-BPS states using the twisted partition function and find that the contribution comes mainly from the untwisted sector. We show that the generating function for these twisted BPS states are related to the Mathieu group M_{24}.

  9. An Envelope Hammerstein Model for Power Amplifiers

    Institute of Scientific and Technical Information of China (English)

    Hua-Dong Wang; Song-Bai He; Jing-Fu Bao; Zheng-De Wu

    2007-01-01

    In this paper, an envelope Hammerstein(EH) model is introduced to describe dynamic inputoutput characteristics of RF power amplifiers. In the modeling approach, we use a new truncation method and an established nonlinear time series method to determine model structure. Then, we discuss the process of model parameter extraction in detailed. Finally, a 2 W WCDMA power amplifier is measured to verify the performance of EH model, and good agreement between model output and measurement result shows our model can accurately predict output characteristic of the power amplifier.

  10. Particle image velocimetry measurements of 2-dimensional velocity field around twisted tape

    Energy Technology Data Exchange (ETDEWEB)

    Song, Min Seop; Park, So Hyun; Kim, Eung Soo, E-mail: kes7741@snu.ac.kr

    2016-11-01

    Highlights: • Measurements of the flow field in a pipe with twisted tape were conducted by particle image velocimetry (PIV). • A novel matching index of refraction technique utilizing 3D printing and oil mixture was adopted to make the test section transparent. • Undistorted particle images were clearly captured in the presence of twisted tape. • 2D flow field in the pipe with twisted tape revealed the characteristic two-peak velocity profile. - Abstract: Twisted tape is a passive component used to enhance heat exchange in various devices. It induces swirl flow that increases the mixing of fluid. Thus, ITER selected the twisted tape as one of the candidates for turbulence promoting in the divertor cooling. Previous study was mainly focused on the thermohydraulic performance of the twisted tape. As detailed data on the velocity field around the twisted tape was insufficient, flow visualization study was performed to provide fundamental data on velocity field. To visualize the flow in a complex structure, novel matching index of refraction technique was used with 3-D printing and mixture of anise and mineral oil. This technique enables the camera to capture undistorted particle image for velocity field measurement. Velocity fields at Reynolds number 1370–9591 for 3 different measurement plane were obtained through particle image velocimetry. The 2-dimensional averaged velocity field data were obtained from 177 pair of instantaneous velocity fields. It reveals the characteristic two-peak flow motion in axial direction. In addition, the normalized velocity profiles were converged with increase of Reynolds numbers. Finally, the uncertainty of the result data was analyzed.

  11. Effective envelope method for Stewart platform workspace

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The workspace of Stewart platform is the intersection of 6 son workspaces of 6 loop chains, so it is important to determine the boundary of the son workspace when locating the boundary of the son workspace. An effectivc envelope method is proposed in this paper. Firstly the envelope theory of a family of singular parameter curve surfaces is used to find the envelope surfaces of the son workspace. Then the numerical method is applied to determine the effective envelope surface. And after that the full boundary of the son workspace, which is the envelope of the effective envelope surfaces, is determined. Finally the workspace can be obtained with a section plane method.

  12. 森林景观“约束包络面”的结构与机制研究%Structure and mechanism of constraint envelope on forest landscape

    Institute of Scientific and Technical Information of China (English)

    陈端吕; 李际平

    2011-01-01

    针对景观类型的关联属性,从核心层次的森林景观类型现实空间关系、高一层次的环境耦合度和干扰作用三个方面分析了森林景观类型“约束包络面”结构作用机制.景观类型的空间关系是对一定时期内景观类型相关的现状描述,隐含了景观类型中林分结构作用机制.环境耦合度反映了森林景观类型两两之间在同一环境条件下共生稳定的状态,衡量的是经营区域系统对森林景观类型格局正向的环境约束.人类干扰通过景观类型斑块动态改变景观类型,是景观类型空间关系的负向约束.在森林景观类型的“约束包络面”中,环境、景观类型与人类干扰共同筑构了高一层次的制控关系、低一层次的递进建构关系和同一层次的演化重构关系.%The mechanism and structure of constraint envelope was discussed by analyzing the relevant property of the forest landscape from real space relationship in core-level, the environment-based coupling degree and human disturbance of the forest landscape in high-level. The spatial relationships of forest landscape types describe present situation of correlation, in which the mechanism of forest stand structure was hidden. The environment-based coupling degree of forest landscape reflected the stable symbiotic state in the same environmental conditions between types of forest landscape and environmental constraints of forest landscape under the regional system. Human disturbance reflected the negative constraints by dynamically changing the landscape patch types. In constraint envelope of the forest landscape types, the environment, landscape structure combining with human disturbance built a higher relationship of control system, which consists of controlling relationships in high-level and the progressive construction relationships in the lower-level and of evolutionary remodeling relationships in the same-level.

  13. Handbook on data envelopment analysis

    CERN Document Server

    Cooper, William W; Zhu, Joe

    2011-01-01

    Focusing on extensively used Data Envelopment Analysis topics, this volume aims to both describe the state of the field and extend the frontier of DEA research. New chapters include DEA models for DMUs, network DEA, models for supply chain operations and applications, and new developments.

  14. Energy efficiency of building envelope

    OpenAIRE

    2014-01-01

    November, 12-13th, in Saint-Petersburg the 7th International congress "Energy efficiency. XXI century" took place. The reports were done in breakuo groups according to the various aspects of energy efficiency challenge: HVAC systems, water supply and sewerage systems, gas supply, energy metering. One of the grourps was devoted to thermophysics of buildings and energy effective design of building envelope.

  15. Envelope Inflation or Stellar Wind?

    Science.gov (United States)

    Ro, S.; Matzner, C. D.

    We an optically-thick, transonic, steady wind model for a H-free Wolf-Rayet star. A bifurcation is found across a critical mass loss rate Mb. Slower winds M interest for extended envelopes and winds, radiative hydrodynamic instabilities (eg. wind stagnation, clumping, etc.), and NLTE atmospheric models.

  16. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature and moist......The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...... and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. The first...... part of the Thesis consists of a theory and literature review on the moisture storage and transport processes (Chapter 2), on the non-Fickian moisture transport (Chapter 3)and on the methods for determining the moisture properties (Chapter 4). In the second part, the conducted experimental work...

  17. On Twisting Real Spectral Triples by Algebra Automorphisms

    Science.gov (United States)

    Landi, Giovanni; Martinetti, Pierre

    2016-11-01

    We systematically investigate ways to twist a real spectral triple via an algebra automorphism and in particular, we naturally define a twisted partner for any real graded spectral triple. Among other things, we investigate consequences of the twisting on the fluctuations of the metric and possible applications to the spectral approach to the Standard Model of particle physics.

  18. On Twisting Real Spectral Triples by Algebra Automorphisms

    Science.gov (United States)

    Landi, Giovanni; Martinetti, Pierre

    2016-08-01

    We systematically investigate ways to twist a real spectral triple via an algebra automorphism and in particular, we naturally define a twisted partner for any real graded spectral triple. Among other things, we investigate consequences of the twisting on the fluctuations of the metric and possible applications to the spectral approach to the Standard Model of particle physics.

  19. Twisting singular solutions of Bethe's equations

    CERN Document Server

    Nepomechie, Rafael I

    2014-01-01

    The Bethe equations for the periodic XXX and XXZ spin chains admit singular solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to be physical, in which case they correspond to genuine eigenvalues and eigenvectors of the Hamiltonian.

  20. Disconnected Loops with Twisted Mass Lattice QCD

    CERN Document Server

    Wilcox, W; Morgan, R; Lewis, R; Wilcox, Walter; Darnell, Dean; Morgan, Ron; Lewis, Randy

    2005-01-01

    We give a general introduction and discussion of the issues involved in using the twisted mass formulation of lattice fermions in the context of disconnected loop calculations, including a short orientation on the present experimental situation for nucleon strange quark form factors. A prototype calculation of the disconnected part of the nucleon scalar form factor is described.

  1. Phase diagram of twisted mass lattice QCD

    Science.gov (United States)

    Sharpe, Stephen R.; Wu, Jackson M.

    2004-11-01

    We use the effective chiral Lagrangian to analyze the phase diagram of two-flavor twisted mass lattice QCD as a function of the normal and twisted masses, generalizing previous work for the untwisted theory. We first determine the chiral Lagrangian including discretization effects up to next-to-leading order (NLO) in a combined expansion in which m2π/(4πfπ)2˜aΛ (a being the lattice spacing, and Λ=ΛQCD). We then focus on the region where m2π/(4πfπ)2˜(aΛ)2, in which case competition between leading and NLO terms can lead to phase transitions. As for untwisted Wilson fermions, we find two possible phase diagrams, depending on the sign of a coefficient in the chiral Lagrangian. For one sign, there is an Aoki phase for pure Wilson fermions, with flavor and parity broken, but this is washed out into a crossover if the twisted mass is nonvanishing. For the other sign, there is a first order transition for pure Wilson fermions, and we find that this transition extends into the twisted mass plane, ending with two symmetrical second order points at which the mass of the neutral pion vanishes. We provide graphs of the condensate and pion masses for both scenarios, and note a simple mathematical relation between them. These results may be of importance to numerical simulations.

  2. Gluon polarization and higher twist effects

    CERN Document Server

    Leader, Elliot; Stamenov, Dimiter

    2008-01-01

    We examine the influence of the recent CLAS and COMPASS experiments on our understanding of higher twist (HT) effects and the gluon polarization, and show how EIC could discriminate between negative and positive gluon polarizations. We comment on the issue of HT and the recent DSSV analysis.

  3. HOMOCLINIC TWIST BIFURCATIONS WITH Z(2) SYMMETRY

    NARCIS (Netherlands)

    ARONSON, DG; VANGILS, SA; KRUPA, M

    1994-01-01

    We analyze bifurcations occurring in the vicinity of a homoclinic twist point for a generic two-parameter family of Z2 equivariant ODEs in four dimensions. The results are compared with numerical results for a system of two coupled Josephson junctions with pure capacitive load.

  4. Redefining B twisted topological sigma models

    NARCIS (Netherlands)

    Jonghe, F. de; Termonia, P.; Troost, W.; Vandoren, S.

    2007-01-01

    The recently proposed procedure to perform the topological B-twist in rigid N = 2 models is applied to the case of the o model on a Kähler manifold. This leads to an alternative description of Witten’s topological o model, which allows for a proper BRST interpretation and ghost number assignement. W

  5. Generalized Weyl modules for twisted current algebras

    Science.gov (United States)

    Makedonskyi, I. A.; Feigin, E. B.

    2017-08-01

    We introduce the notion of generalized Weyl modules for twisted current algebras. We study their representation-theoretic and combinatorial properties and also their connection with nonsymmetric Macdonald polynomials. As an application, we compute the dimension of the classical Weyl modules in the remaining unknown case.

  6. Analysis of Cohesion inOliver Twist

    Institute of Scientific and Technical Information of China (English)

    程文文

    2016-01-01

    Cohesion is an important concept in the study of stylistics. This thesis aims to study the applications of cohesion in the Charles Dicken’ world-famous novelOliver Twist, including both the grammatical and lexical cohesive devices in the work.

  7. Energy Release in Driven Twisted Coronal Loops

    Science.gov (United States)

    Bareford, M. R.; Gordovskyy, M.; Browning, P. K.; Hood, A. W.

    2016-01-01

    We investigate magnetic reconnection in twisted magnetic fluxtubes, representing coronal loops. The main goal is to establish the influence of the field geometry and various thermodynamic effects on the stability of twisted fluxtubes and on the size and distribution of heated regions. In particular, we aim to investigate to what extent the earlier idealised models, based on the initially cylindrically symmetric fluxtubes, are different from more realistic models, including the large-scale curvature, atmospheric stratification, thermal conduction and other effects. In addition, we compare the roles of Ohmic heating and shock heating in energy conversion during magnetic reconnection in twisted loops. The models with straight fluxtubes show similar distribution of heated plasma during the reconnection: it initially forms a helical shape, which subsequently becomes very fragmented. The heating in these models is rather uniformly distributed along fluxtubes. At the same time, the hot plasma regions in curved loops are asymmetric and concentrated close to the loop tops. Large-scale curvature has a destabilising influence: less twist is needed for instability. Footpoint convergence normally delays the instability slightly, although in some cases, converging fluxtubes can be less stable. Finally, introducing a stratified atmosphere gives rise to decaying wave propagation, which has a destabilising effect.

  8. Conformational transformations of sulfur-containing rings: 2-methyltetrahydrothiophene gas-phase structures.

    Science.gov (United States)

    Van, Vinh; Dindic, Christina; Nguyen, Ha Vinh Lam; Stahl, Wolfgang

    2015-02-02

    Stable conformations of five-member rings with the prototype cyclopentane are well-known to exist as twist or envelope structures and are of general interest in chemistry. Here, we report on the conformational analysis of the sulfur-containing ring 2-methyltetrahydrothiophene studied by a combination of molecular beam Fourier transform microwave (MB-FTMW) spectroscopy and quantum chemistry. Two twist conformers were observed, whereby highly accurate molecular parameters could be determined. In addition, the (34) S-isotopologue of the most stable conformer was assigned in natural abundances. Geometry optimizations were performed at different levels of theory and the calculated rotational constants were compared with experimental values. Two transition states optimized at the MP2/6-311++G(d,p) level using the Berny algorithm could illustrate the intramolecular conversion between both conformers.

  9. Resonant absorption of kink magnetohydrodynamic waves by a magnetic twist in coronal loops

    Science.gov (United States)

    Ebrahimi, Zanyar; Karami, Kayoomars

    2016-10-01

    There is ample evidence of twisted magnetic structures in the solar corona. This motivates us to consider the magnetic twist as the cause of Alfvén frequency continuum in coronal loops, which can support the resonant absorption as a rapid damping mechanism for the observed coronal kink magnetohydrodynamic (MHD) oscillations. We model a coronal loop with a straight cylindrical magnetic flux tube, which has constant but different densities in the interior and exterior regions. The magnetic field is assumed to be constant and aligned with the cylinder axis everywhere except for a thin layer near the boundary of the flux tube, which has an additional small magnetic field twist. Then, we investigate a number of possible instabilities that may arise in our model. In the thin tube thin boundary approximation, we derive the dispersion relation and solve it analytically to obtain the frequencies and damping rates of the fundamental (l = 1) and first/second overtone (l = 2, 3) kink (m = 1) MHD modes. We conclude that the resonant absorption by the magnetic twist can justify the rapid damping of kink MHD waves observed in coronal loops. Furthermore, the magnetic twist in the inhomogeneous layer can cause deviations from P1/P2 = 2 and P1/P3 = 3, which are comparable with the observations.

  10. Resonant absorption of kink MHD waves by magnetic twist in coronal loops

    CERN Document Server

    Ebrahimi, Z

    2015-01-01

    There is ample evidences of twisted magnetic structures in the corona. This motivates us to consider the magnetic twist as the cause of Alfven frequency continuum in coronal loops, which can support the resonant absorption as the rapid damping mechanism for the observed coronal kink MHD oscillations. For a straight cylindrical compressible zero-beta thin flux tube with a magnetic twist in a thin boundary and straight magnetic field in the interior and exterior regions as well as a step-like radial density profile, we derive the dispersion relation and solve it analytically. Consequently, we obtain the frequencies and damping rates of the fundamental (l=1) and first/second overtones (l=2,3) kink (m=1) MHD modes. We conclude that the resonant absorption by the magnetic twist can justify the rapid damping of kink MHD waves observed in coronal loops. Furthermore, the magnetic twist in the inhomogeneous layer can achieve deviations from P_1/P_2=2 and P_1/P_3=3 of the same order of magnitude as in the observations.

  11. Higher Twist Distribution Amplitudes of the Nucleon in QCD

    CERN Document Server

    Braun, V M; Mahnke, N; Stein, E

    2000-01-01

    We present the first systematic study of higher-twist light-cone distribution amplitudes of the nucleon in QCD. We find that the valence three-quark state is described at small transverse separations by eight independent distribution amplitudes. One of them is leading twist-3, three distributions are twist-4 and twist-5, respectively, and one is twist-6. A complete set of distribution amplitudes is constructed, which satisfies equations of motion and constraints that follow from conformal expansion. Nonperturbative input parameters are estimated from QCD sum rules.

  12. Effects of Head Size on the Performance of Twist-Off Bolts

    OpenAIRE

    Schnupp, Keith Otto

    2003-01-01

    This study examines a specific application of button-head type twist-off bolts. Currently, the Research Council on Structural Connections Specification (2000) removes the requirement for ASTM F436 washers (ASTM 2000a) under the bolt head of twist-off bolts where the head diameter equals or exceeds that of an ASTM F436 washer when oversized and slotted holes are used. The need for washers is also removed for A490 strength bolts used on steels with specified yield strengths less than 40 ksi p...

  13. Polarized Parton Densities and Higher Twist in the Light of the Recent CLAS and COMPASS data

    CERN Document Server

    Leader, Elliot; Stamenov, Dimiter B

    2007-01-01

    The impact of the recent very precise CLAS and COMPASS g_1/F_1 data on polarized parton densities and higher twist effects is discussed. We demonstrate that the low Q^2 CLAS data improve essentially our knowledge of higher twist corrections to the spin structure function g1, while the large Q^2 COMPASS data influence mainly the strange quark and gluon polarizations which slightly decrease. We find also that the present inclusive DIS data cannot rule out a negative polarized and changing in sign gluon densities.

  14. Stage-dependent changes of the nuclear architecture, envelope and lamina during mammalian early embryonic development studied with a novel 3D structured illumination microscopy protocol

    OpenAIRE

    Popken, Jens

    2016-01-01

    Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) features an 8-fold volumetric resolution improvement over conventional microscopy and is well established on flat, adherent cells. However, blastomeres in mammalian embryos are non-adherent, round and large. Scanning whole mount mammalian embryos with 3D-SIM is prone to failure due to non-adherent embryos moving during scanning and a large distance to the cover glass. The biggest challenge an...

  15. Sequence effects of twist extrusion and rolling on microstructure and mechanical properties of aluminum alloy 8112

    Energy Technology Data Exchange (ETDEWEB)

    Bahadori, Sh Ranjbar; Mousavi, S A A Akbari; Shahab, A R, E-mail: shrb1984@yahoo.co [School of Metallurgy and Materials Engineering, University College of Engineering, University of Tehran, Tehran, PO Box: 11155-4563 (Iran, Islamic Republic of)

    2010-07-01

    Recently severe plastic deformation processes have been the essence of metal forming researches to produce ultrafine-grained materials. Twist Extrusion (TE) is one of the most unprecedented methods developed in recent years, but remained in laboratory scales. The main reason for this matter refers to some deficiencies like microstructure heterogeneity occurring after TE. However, employing conventional forming techniques could make TE industrial and, moreover, reduce the bulk structure grain size. Using a conventional forming process such as rolling after twist extrusion has been suggested by this paper. T.E process of Al 8112 samples was carried out using a twisted die with 60{sup 0} die angle and the samples were processed through rolling subsequently. The results demonstrated that implementation of rolling not only reduced heterogeneity but also decreased the grain size and, consequently, enhanced the bulk strength.

  16. Dynamic investigation of twist-bend coupling in a wind turbine blade

    DEFF Research Database (Denmark)

    Luczak, M.; Manzato, S.; Peeters, B.;

    2011-01-01

    This paper presents some results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study in static and dynamic domains on the bend-twist coupling in the full scale section of a wind turbine blade structure. The main goal of the conducted...... research is to confirm experimentally the numerical prediction of modification of the dynamic and static properties of a wind turbine blade. The bend-twist coupling was implemented by adding angled UD (UniDirectional) layers on the suction and pressure side of the blade. Static and dynamic tests were...... performed on a section of the full scale wind turbine blade provided by VestasWind Systems A/S. The results are presented and compared with the measurements of the original and modified blade. Comparison analysis confirmed that UD layers introduce measurable bend-twist couplings, which was not present...

  17. Dynamic investigation of twist-bend coupling in a wind turbine blade

    DEFF Research Database (Denmark)

    Luczak, M.; Manzato, S.; Peeters, B.

    2011-01-01

    This paper presents some results and aspects of the multidisciplinary and interdisciplinary research oriented for the experimental and numerical study in static and dynamic domains on the bend-twist coupling in the full scale section of a wind turbine blade structure. The main goal of the conducted...... research is to confirm experimentally the numerical prediction of modification of the dynamic and static properties of a wind turbine blade. The bend-twist coupling was implemented by adding angled UD (UniDirectional) layers on the suction and pressure side of the blade. Static and dynamic tests were...... performed on a section of the full scale wind turbine blade provided by VestasWind Systems A/S. The results are presented and compared with the measurements of the original and modified blade. Comparison analysis confirmed that UD layers introduce measurable bend-twist couplings, which was not present...

  18. Plant nuclear envelope proteins.

    Science.gov (United States)

    Rose, Annkatrin; Patel, Shalaka; Meier, Iris

    2004-01-01

    Compared to research in the animal field, the plant NE has been clearly under-investigated. The available data so far indicate similarities as well as striking differences that raise interesting questions about the function and evolution of the NE in different kingdoms. Despite a seemingly similar structure and organization of the NE, many of the proteins that are integral components of the animal NE appear to lack homologues in plant cells. The sequencing of the Arabidopsis genome has not led to the identification of homologues of animal NE components, but has indicated that the plant NE must have a distinct protein composition different from that found in metazoan cells. Besides providing a selective barrier between the nucleoplasm and the cytoplasm, the plant NE functions as a scaffold for chromatin but the scaffolding components are not identical to those found in animal cells. The NE comprises an MTOC in higher plant cells, a striking difference to the organization of microtubule nucleation in other eukaryotic cells. Nuclear pores are present in the plant NE, but identifiable orthologues of most animal and yeast nucleoporins are presently lacking. The transport pathway through the nuclear pores via the action of karyopherins and the Ran cycle is conserved in plant cells. Interestingly, RanGAP is sequestered to the NE in plant cells and animal cells, yet the targeting domains and mechanisms of attachment are different between the two kingdoms. At present, only a few proteins localized at the plant NE have been identified molecularly. Future research will have to expand the list of known protein components involved in building a functional plant NE.

  19. Critical core mass for enriched envelopes: the role of H2O condensation

    CERN Document Server

    Venturini, J; Benz, W; Ikoma, M

    2015-01-01

    Context. Within the core accretion scenario of planetary formation, most simulations performed so far always assume the accreting envelope to have a solar composition. From the study of meteorite showers on Earth and numerical simulations, we know that planetesimals must undergo thermal ablation and disruption when crossing a protoplanetary envelope. Once the protoplanet has acquired an atmosphere, the primordial envelope gets enriched in volatiles and silicates from the planetesimals. This change of envelope composition during the formation can have a significant effect in the final atmospheric composition and on the formation timescale of giant planets. Aims. To investigate the physical implications of considering the envelope enrichment of protoplanets due to the disruption of icy planetesimals during their way to the core. Particular focus is placed on the effect on the critical core mass for envelopes where condensation of water can occur. Methods. Internal structure models are numerically solved with th...

  20. Analysis of seismogram envelopes. State of the art and future developments; Jishin hakei no envelope kaiseki. Genjo to kongo no kadai

    Energy Technology Data Exchange (ETDEWEB)

    Sato, H. [Tohoku University, Sendai (Japan)

    1998-10-01

    Reviewed herein are researches on seismogram envelopes of small earthquakes and observations. The physical exploration tries to search for coherent portions in the waves by array observation, to detect strong contrasts in underground structures. Analysis of seismogram envelopes is much different from the above. The coda wave in the seismogram of local earthquake is characterized by a structure of random short-waves overlapping three-dimensionally the upper surface of a gradually changing structure. This paper describes characteristics of heterogeneous earth structures and coda waves, modeling based on the radiation propagation theories, and simulation and analysis examples of 3-component, total waveform envelopes, based on the Born approximation in the theory of elasticity. It also outlines the envelopes, in the seismograms of earthquakes which have occurred in the Kanto and Tokai districts, changing from a pulse-shape to spindle-shape, theoretical models developed by diffractiometry for strongly random heterogeneous structures, and future research prospects. 37 refs., 28 figs.

  1. Correlation between carbohydrate structures on the envelope glycoprotein gp120 of HIV-1 and HIV-2 and syncytium inhibition with lectins

    DEFF Research Database (Denmark)

    Hansen, J E; Nielsen, C M; Nielsen, C

    1989-01-01

    agglutinin, Pisum sativum agglutinin and phytohaem(erythro)agglutinin bound to gp120 of all three isolates. The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated...... complex type glycan and a triantennary bisected complex type glycan. Only lectins which bound at least one of the four types of glycans were capable of inhibiting fusion of HIV-infected cells with CD4 cells by a carbohydrate-specific interaction with the HIV-infected cells. Thus, several different glycan...... structures may be implicated in CD4-gp120 binding....

  2. Economy Discussion on Energy Conservation Design of Envelope Structure of Multi-storey Residence in Chongqing%重庆地区多层住宅围护结构节能设计经济性探讨

    Institute of Scientific and Technical Information of China (English)

    周强; 王永超; 周书兵; 毛伟

    2014-01-01

    随着围护结构节能设计要求的不断提升,节能材料的成本价格也在日趋增高。住宅建筑在建筑总量中占有相当大的比重,有必要对其节能设计的经济性进行探讨。文章调研了重庆地区多层住宅围护结构主要部位传热系数情况和重庆地区保温材料现行市场价格,对满足相同传热系数的不同材料进行了经济性比对分析。此外,还对重庆主城区的典型多层住宅建筑进行节能模拟分析,选定不同的材料组合方案,比较分析其成本因素,得到满足节能规范要求并且成本较优的多层住宅围护结构节能设计策略。%With the gradual increase of requirements on energy conservation design of building envelope structure, the cost of energy conservation mate-rials is also on the rise. As the residential building accounts for the biggest proportion, it is necessary to explore the economy of energy conservation de-sign. The heat transfer coefficients of the major parts of the building envelope used in multi-storey residential building and the market price of thermal in-sulation materials in Chongqing are investigated and the economy of different materials with the same heat transfer coefficient is comparatively analyzed. Moreover, the energy conservation of the typical multi-storey residence in Chongqing is simulated and analyzed to select different material combination plans and comparatively analyzed their cost reasons so that a best energy conservation design can be obtained.

  3. DNA origami-based nanoribbons: assembly, length distribution, and twist

    Energy Technology Data Exchange (ETDEWEB)

    Jungmann, Ralf; Scheible, Max; Kuzyk, Anton; Pardatscher, Guenther; Simmel, Friedrich C [Lehrstuhl fuer Bioelektronik, Physik-Department and ZNN/WSI, Technische Universitaet Muenchen, Am Coulombwall 4a, 85748 Garching (Germany); Castro, Carlos E, E-mail: simmel@ph.tum.de [Labor fuer Biomolekulare Nanotechnologie, Physik-Department and ZNN/WSI, Technische Universitaet Muenchen, Am Coulombwall 4a, 85748 Garching (Germany)

    2011-07-08

    A variety of polymerization methods for the assembly of elongated nanoribbons from rectangular DNA origami structures are investigated. The most efficient method utilizes single-stranded DNA oligonucleotides to bridge an intermolecular scaffold seam between origami monomers. This approach allows the fabrication of origami ribbons with lengths of several micrometers, which can be used for long-range ordered arrangement of proteins. It is quantitatively shown that the length distribution of origami ribbons obtained with this technique follows the theoretical prediction for a simple linear polymerization reaction. The design of flat single layer origami structures with constant crossover spacing inevitably results in local underwinding of the DNA helix, which leads to a global twist of the origami structures that also translates to the nanoribbons.

  4. Moisture Dynamics in Building Envelopes

    DEFF Research Database (Denmark)

    Peuhkuri, Ruut Hannele

    2003-01-01

    The overall scope of this Thesis "Moisture dynamics in building envelopes" has been to characterise how the various porous insulation materials investigated performed hygrothermally under conditions similar to those in a typical building envelope. As a result of the changing temperature...... and moisture conditions in the exterior weather and indoor climate the materials dynamically absorb and release moisture. The complexity of the impact of these conditions on the resulting moisture transport and content of the materials has been studied in this Thesis with controlled laboratory tests. The first......, results, and analysis are presented (Chapters 5-7). The major findings are discussed (Chapter 8), before the final conclusion (Chapter 9). The Appendices include the material parameters used, some additional results and the description of the simulation models....

  5. Influence of tension-twisting deformations and defects on optical and electrical properties of B, N doped carbon nanotube superlattices

    Science.gov (United States)

    Guili, Liu; Yan, Jiang; Yuanyuan, Song; Shuang, Zhou; Tianshuang, Wang

    2016-06-01

    As the era of nanoelectronics is dawning, CNT (carbon nanotube), a one-dimensional nano material with outstanding properties and performances, has aroused wide attention. In order to study its optical and electrical properties, this paper has researched the influence of tension-twisting deformation, defects, and mixed type on the electronic structure and optical properties of the armchair carbon nanotube superlattices doped cyclic alternately with B and N by using the first-principle method. Our findings show that if tension-twisting deformation is conducted, then the geometric structure, bond length, binding energy, band gap and optical properties of B, N doped carbon nanotube superlattices with defects and mixed type will be influenced. As the degree of exerted tension-twisting deformation increases, B, N doped carbon nanotube superlattices become less stable, and B, N doped carbon nanotube superlattices with defects are more stable than that with exerted tension-twisting deformations. Proper tension-twisting deformation can adjust the energy gap of the system; defects can only reduce the energy gap, enhancing the system metallicity; while the mixed type of 5% tension, twisting angle of 15° and atomic defects will significantly increase the energy gap of the system. From the perspective of optical properties, doped carbon nanotubes may transform the system from metallicity into semi-conductivity. Project supported by the National Natural Science Foundation of China (No. 51371049) and the Natural Science Foundation of Liaoning Province (No. 20102173).

  6. Discussion on energy saving technology of building envelop enclosure structure exterior%谈建筑围护结构外墙节能技术

    Institute of Scientific and Technical Information of China (English)

    刘晋凤

    2016-01-01

    介绍了建筑外墙结构的保温技术,论述了外墙外保温技术的优势,分析了聚苯板薄抹灰外墙外保温施工中的技术问题,总结出施工中的几点建议与技术措施,从而提高了建筑围护结构的节能水平,减少了资源浪费.%The paper introduced the thermal insulation technology of building exterior structure,discussed the advantages of external wall thermal insulation technology,analyzed the technical problems in polystyrene board external wall thermal insulation construction,summarized several sug-gestions and technical measures in construction,so as to improve the energy saving level of building exterior,reduced the resources waste.

  7. Safeguards Envelope Progress FY08

    Energy Technology Data Exchange (ETDEWEB)

    Robert Bean; Richard Metcalf; Aaron Bevill

    2008-09-01

    The Safeguards Envelope Project met its milestones by creating a rudimentary safeguards envelope, proving the value of the approach on a small scale, and determining the most appropriate path forward. The Idaho Chemical Processing Plant’s large cache of reprocessing process monitoring data, dubbed UBER Data, was recovered and used in the analysis. A probabilistic Z test was used on a Markov Monte Carlo simulation of expected diversion data when compared with normal operating data. The data regarding a fully transient event in a tank was used to create a simple requirement, representative of a safeguards envelope, whose impact was a decrease in operating efficiency by 1.3% but an increase in material balance period of 26%. This approach is operator, state, and international safeguards friendly and should be applied to future reprocessing plants. Future requirements include tank-to-tank correlations in reprocessing facilities, detailed operations impact studies, simulation inclusion, automated optimization, advanced statistics analysis, and multi-attribute utility analysis.

  8. On the {\\alpha} formalism for the common envelope interaction

    CERN Document Server

    De Marco, Orsola; Moe, Maxwell; Herwig, Falk; Mac Low, Mordecai-Mark; Paxton, Bill

    2010-01-01

    The {\\alpha}-formalism is a common way to parametrize the common envelope interaction between a giant star and a more compact companion. The {\\alpha} parameter describes the fraction of orbital energy released by the companion that is available to eject the giant star's envelope. By using new, detailed stellar evolutionary calculations we derive a user-friendly prescription for the {\\lambda} parameter and an improved approximation for the envelope binding energy, thus revising the {\\alpha} equation. We then determine {\\alpha} both from simulations and observations in a self consistent manner. By using our own stellar structure models as well as population considerations to reconstruct the primary's parameters at the time of the common envelope interaction, we gain a deeper understanding of the uncertainties. We find that systems with very low values of q (the ratio of the companion's mass to the mass of the primary at the time of the common envelope interaction) have higher values of {\\alpha}. A fit to the da...

  9. Calculation of CWKB envelope in boson and fermion productions

    Indian Academy of Sciences (India)

    S Biswas; I Chowdhury

    2007-01-01

    We present the calculation of envelope of boson and of both low- and high- mass fermion production at the end of inflation when the coherently oscillating inflatons decay into bosons and fermions. We consider three different models of inflation and use CWKB technique to calculate the envelope to understand the structure of resonance band formation. We observe that though low-mass fermion production is not effective in pre-heating because of Pauli blocking, it is quite probable for high-mass fermion to take part in pre-heating.

  10. Twisted black hole is Taub-NUT

    Science.gov (United States)

    Ong, Yen Chin

    2017-01-01

    Recently a purportedly novel solution of the vacuum Einstein field equations was discovered: it supposedly describes an asymptotically flat twisted black hole in 4-dimensions whose exterior spacetime rotates in a peculiar manner—the frame dragging in the northern hemisphere is opposite from that of the southern hemisphere, which results in a globally vanishing angular momentum. Furthermore it was shown that the spacetime has no curvature singularity. We show that the geometry of this black hole spacetime is nevertheless not free of pathological features. In particular, it harbors a rather drastic conical singularity along the axis of rotation. In addition, there exist closed timelike curves due to the fact that the constant r and constant t surfaces are not globally Riemannian. In fact, none of these are that surprising since the solution is just the Taub-NUT geometry. As such, despite the original claim that the twisted black hole might have observational consequences, it cannot be.

  11. Magnetic Field Twisting by Intergranular Downdrafts

    Science.gov (United States)

    Taroyan, Youra; Williams, Thomas

    2016-10-01

    The interaction of an intergranular downdraft with an embedded vertical magnetic field is examined. It is demonstrated that the downdraft may couple to small magnetic twists leading to an instability. The descending plasma exponentially amplifies the magnetic twists when it decelerates with depth due to increasing density. Most efficient amplification is found in the vicinity of the level, where the kinetic energy density of the downdraft reaches equipartition with the magnetic energy density. Continual extraction of energy from the decelerating plasma and growth in the total azimuthal energy occurs as a consequence of the wave-flow coupling along the downdraft. The presented mechanism may drive vortices and torsional motions that have been detected between granules and in simulations of magnetoconvection.

  12. Factorising the 3D Topologically Twisted Index

    CERN Document Server

    Cabo-Bizet, Alejandro

    2016-01-01

    In this work, path integral representations of the 3D topologically twisted index were studied. First, the index can be "factorised" into a couple of "blocks". The "blocks" being the partition functions of a type A semi-topological twisting of 3D N = 2 SYM placed on $\\mathbb{S}_2\\times (0, \\pi)$ and $\\mathbb{S}_2 \\times (\\pi, 2 \\pi)$ respectively. Second, as the path integral of the aforementioned theory over $\\mathbb{S}_2$ times $\\mathbb{S}_1$ with a point excluded. In this way we recover the sum over fluxes from integration over the real path and without sacrificing positive definiteness of the bosonic part of the localising action. We also reproduce the integration over the complex contour by using the localising term with positive definite bosonic part.

  13. Tinkertoys for the Twisted D-Series

    CERN Document Server

    Chacaltana, Oscar; Trimm, Anderson

    2013-01-01

    We study 4D N=2 superconformal field theories that arise from the compactification of 6D N=(2,0) theories of type D_N on a Riemann surface, in the presence of punctures twisted by a Z_2 outer automorphism. Unlike the untwisted case, the family of SCFTs is in general parametrized, not by M_{g,n}, but by a branched cover thereof. The classification of these SCFTs is carried out explicitly in the case of the D_4 theory, in terms of three-punctured spheres and cylinders, and we provide tables of properties of twisted punctures for the D_5 and D_6 theories. We find realizations of Spin(8) and Spin(7) gauge theories with matter in all combinations of vector and spinor representations with vanishing beta-function, as well as Sp(3) gauge theories with matter in the 3-index traceless antisymmetric representation.

  14. AM Envelope: The Potential of Additive Manufacturing for facade constructions

    NARCIS (Netherlands)

    Strauss, H.

    2013-01-01

    The continuous development of the building envelope over the past hundred years can be exemplified by a few ground-breaking inventions. Firstly, the separation of primary and secondary structure during the beginning of the 20th century; by implementing a curtain wall façade to physically separate

  15. AM Envelope: The Potential of Additive Manufacturing for facade constructions

    NARCIS (Netherlands)

    Strauss, H.

    2013-01-01

    The continuous development of the building envelope over the past hundred years can be exemplified by a few ground-breaking inventions. Firstly, the separation of primary and secondary structure during the beginning of the 20th century; by implementing a curtain wall façade to physically separate th

  16. Development and Evaluation of a Responsive Building Envelope

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Foged, Isak Worre

    2011-01-01

    different shape alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock-up concept...

  17. Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.

    Science.gov (United States)

    Bouard, Charlotte; Terreux, Raphael; Hope, Jennifer; Chemelle, Julie Anne; Puisieux, Alain; Ansieau, Stéphane; Payen, Léa

    2014-01-01

    The basic helix-loop-helix (bHLH) transcription factor TWIST1 is essential to embryonic development, and hijacking of its function contributes to the development of numerous cancer types. It forms either a homodimer or a heterodimeric complex with an E2A or HAND partner. These functionally distinct complexes display sometimes antagonistic functions during development, so that alterations in the balance between them lead to pronounced morphological alterations, as observed in mice and in Saethre-Chotzen syndrome patients. We, here, describe the structures of TWIST1 bHLH-DNA complexes produced in silico through molecular dynamics simulations. We highlight the determinant role of the interhelical loops in maintaining the TWIST1-DNA complex structures and provide a structural explanation for the loss of function associated with several TWIST1 mutations/insertions observed in Saethre-Chotzen syndrome patients. An animated interactive 3D complement (I3DC) is available in Proteopedia at http://proteopedia.org/w/Journal:JBSD:27.

  18. Second-order envelope equation of graphene electrons

    Science.gov (United States)

    Luo, Ji

    2014-10-01

    A treatment of graphene's electronic states based on the tight-binding method is presented. Like Dirac equation, this treatment uses envelope functions to eliminate crystal potential. Besides, a density-functional-theory Kohn-Sham (KS) orbital of an isolated carbon atom is employed. By locally expanding envelope functions into second-order polynomials and by involving up to third-nearest atoms in calculating orbital integrals, the second-order envelope equation is obtained. This equation does not contain any experimental data except graphene's crystal structure, and its coefficients are determined through several kinds of integrals of the carbon KS orbital. As an improvement, it leads to more accurate energy dispersion than Dirac equation including the triangular warping effect and asymmetry for electrons and holes, and gives the Fermi velocity which is in good agreement with the experimental value.

  19. Efficiency of Planetesimal Ablation in Giant Planetary Envelopes

    CERN Document Server

    Pinhas, Arazi; Clarke, Cathie

    2016-01-01

    Observations of exoplanetary spectra are leading to unprecedented constraints on their atmospheric elemental abundances, particularly O/H, C/H, and C/O ratios. Recent studies suggest that elemental ratios could provide important constraints on formation and migration mechanisms of giant exoplanets. A fundamental assumption in such studies is that the chemical composition of the planetary envelope represents the sum-total of compositions of the accreted gas and solids during the formation history of the planet. We investigate the efficiency with which accreted planetesimals ablate in a giant planetary envelope thereby contributing to its composition rather than sinking to the core. From considerations of aerodynamic drag causing `frictional ablation' and the envelope temperature structure causing `thermal ablation', we compute mass ablations for impacting planetesimals of radii 30 m to 1 km for different compositions (ice to iron) and a wide range of velocities and impact angles, assuming spherical symmetry. I...

  20. Computer-based comparison of structural features of envelope protein of Alkhurma hemorrhagic fever virus with the homologous proteins of two closest viruses.

    Science.gov (United States)

    Mohabatkar, Hassan

    2011-06-01

    The aim of this study was prediction of epitopes and medically important structural properties of protein E of Alkhurma hemorrhagic fever virus (AHFV) and comparing these features with two closely relates viruses, i.e. Kyasanur Forest disease virus (KFDV) and Tick-borne encephalitis virus (TBEV) by bioinformatics tools. Prediction of evolutionary distance, localization, sequence of signal peptides, C, N O glycosylation sites, transmembrane helices (TMHs), cysteine bond positions and B cell and T cell epitopes of E proteins were performed. 2D-MH, Virus-PLoc, Signal-CF, EnsembleGly, MemBrain, DiANNA, BCPREDS and MHCPred servers were applied for the prediction. According to the results, the evolutionary distance of E protein of AHFV and two other viruses was almost equal. In all three proteins of study, residues 1-35 were predicted as signal sequences and one asparagine was predicted to be glycosylated. Results of prediction of transmembrane helices showed one TMH at position 444-467 and the other one at position 476-490. Twelve cysteines were potentially involved to form six disulfide bridges in the proteins. Four parts were predicted as B cell epitopes in E protein of AHFV. One epitope was conserved between three proteins of study. The only conserved major histocompatibility complex (MHC) binding epitope between three viruses was for DRB0401 allele. As there are not much experimental data available about AHFV, computer-aided study and comparison of E protein of this virus with two closely related flaviviruses can help in better understanding of medical properties of the virus.

  1. Overlap fermions on a twisted mass sea

    CERN Document Server

    Bär, O; Schäefer, S; Scorzato, L; Shindler, A

    2006-01-01

    We present first results of a mixed action project. We analyze gauge configurations generated with two flavors of dynamical twisted mass fermions. Neuberger's overlap Dirac operator is used for the valence sector. The various choices in the setup of the simulation are discussed. We employ chiral perturbation theory to describe the effects of using different actions in the sea and valence sector at non-zero lattice spacing.

  2. Disconnected diagrams with twisted-mass fermions

    CERN Document Server

    Abdel-Rehim, Abdou; Constantinou, Martha; Finkenrath, Jacob; Hadjiyiannakou, Kyriakos; Jansen, Karl; Kallidonis, Christos; Koutsou, Giannis; Avilés-Casco, Alejandro Vaquero

    2016-01-01

    The latest results from the Twisted-Mass collaboration on disconnected diagrams at the physical value of the pion mass are presented. In particular, we focus on the sigma terms, the axial charges and the momentum fraction, all of them for the nucleon. A detailed error analysis for each observable follows, showing the strengths and weaknesses of the one-end trick. Alternatives are discussed.

  3. DNA Packaging in Bacteriophage: Is Twist Important?

    OpenAIRE

    Spakowitz, Andrew James; Wang, Zhen-Gang

    2005-01-01

    We study the packaging of DNA into a bacteriophage capsid using computer simulation, specifically focusing on the potential impact of twist on the final packaged conformation. We perform two dynamic simulations of packaging a polymer chain into a spherical confinement: one where the chain end is rotated as it is fed, and one where the chain is fed without end rotation. The final packaged conformation exhibits distinct differences in these two cases: the packaged conformation from feeding with...

  4. On rectangular HOMFLY for twist knots

    CERN Document Server

    Kononov, Ya

    2016-01-01

    As a new step in the study of rectangularly-colored knot polynomials, we reformulate the prescription of arXiv:1606.06015 for twist knots in the double-column representations $R=[rr]$ in terms of skew Schur polynomials. These, however, are mysteriously shifted from the standard topological locus, what makes further generalization to arbitrary $R=[r^s]$ not quite straightforward.

  5. Ferromagnetic nanoparticles suspensions in twisted nematic

    Science.gov (United States)

    Cîrtoaje, Cristina; Petrescu, Emil; Stan, Cristina; Creangă, Dorina

    2016-05-01

    Ferromagnetic nanoparticles insertions in nematic liquid crystals (NLC) in twisted configuration are studied and a theoretical model is proposed to explain the results. Experimental observation revealed that nanoparticles tend to overcrowd in long strings parallel to the rubbing direction of the alignment substrate of the LC cell. Their behavior under external field was studied and their interaction with their nematic host is described using elastic continuum theory.

  6. Twisted spectral geometry for the standard model

    CERN Document Server

    Martinetti, Pierre

    2015-01-01

    The Higgs field is a connection one-form as the other bosonic fields, provided one describes space no more as a manifold M but as a slightly non-commutative generalization of it. This is well encoded within the theory of spectral triples: all the bosonic fields of the standard model - including the Higgs - are obtained on the same footing, as fluctuations of a generalized Dirac operator by a matrix-value algebra of functions on M. In the commutative case, fluctuations of the usual free Dirac operator by the complex-value algebra A of smooth functions on M vanish, and so do not generate any bosonic field. We show that imposing a twist in the sense of Connes-Moscovici forces to double the algebra A, but does not require to modify the space of spinors on which it acts. This opens the way to twisted fluctuations of the free Dirac operator, that yield a perturbation of the spin connection. Applied to the standard model, a similar twist yields in addition the extra scalar field needed to stabilize the electroweak v...

  7. From Cylindrical to Stretching Ridges and Wrinkles in Twisted Ribbons

    Science.gov (United States)

    Pham Dinh, Huy; Démery, Vincent; Davidovitch, Benny; Brau, Fabian; Damman, Pascal

    2016-09-01

    Twisted ribbons under tension exhibit a remarkably rich morphology, from smooth and wrinkled helicoids, to cylindrical or faceted patterns. This complexity emanates from the instability of the natural, helicoidal symmetry of the system, which generates both longitudinal and transverse stresses, thereby leading to buckling of the ribbon. Here, we focus on the tessellation patterns made of triangular facets. Our experimental observations are described within an "asymptotic isometry" approach that brings together geometry and elasticity. The geometry consists of parametrized families of surfaces, isometric to the undeformed ribbon in the singular limit of vanishing thickness and tensile load. The energy, whose minimization selects the favored structure among those families, is governed by the tensile work and bending cost of the pattern. This framework describes the coexistence lines in a morphological phase diagram, and determines the domain of existence of faceted structures.

  8. CP phase from twisted Higgs VEV in extra dimension

    CERN Document Server

    Fujimoto, Yukihiro; Sakamoto, Makoto

    2013-01-01

    We propose a new mechanism for generating CP phase via Higgs vacuum expectation value originating from geometry of an extra dimension. Allowing a twisted boundary condition for the Higgs doublet drives us into an extra-dimension-coordinate-dependent vacuum expectation value containing a CP phase degree of freedom. With this mechanism, we construct a phenomenological model on S1 which can simultaneously and naturally explain the origin of fermion generation, quark mass hierarchy, and the structure of the Cabibbo-Kobayashi-Maskawa matrix with the CP phase. By introducing point interactions, which are additional boundary points on S1, the 5D quarks realize the three generations. Our situation is phenomenologically-preferred one since all the flavor structures are realized with good precision and almost all dimensionless scaled parameters take values of natural O(10) magnitudes. An almost exponential vacuum expectation value profile of a scalar singlet, which appears in the Yukawa sector, helps the naturalness in...

  9. Sexual coevolution of spermatophore envelopes and female genital traits in butterflies: Evidence of male coercion?

    Directory of Open Access Journals (Sweden)

    Víctor Sánchez

    2014-01-01

    Full Text Available Signa are sclerotized structures located on the inner wall of the corpus bursa of female Lepidoptera whose main function is tearing open spermatophores. The sexually antagonistic coevolution (SAC hypothesis proposes that the thickness of spermatophore envelopes has driven the evolution of the females signa; this idea is based in the fact that in many lepidopterans female sexual receptivity is at least partially controlled by the volume of ejaculate remaining in the corpus bursa. According to the SAC hypothesis, males evolved thick spermatophore envelopes to delay the post-mating recovery of female sexual receptivity thus reducing sperm competition; in response, females evolved signa for breaking spermatophore envelopes faster, gaining access to the resources contained in them and reducing their intermating intervals; the evolution of signa, in turn, favored the evolution of even thicker spermatophore envelopes, and so on. We tested two predictions of the SAC hypothesis with comparative data on the thickness of spermatophore envelopes of eleven species of Heliconiinae butterflies. The first prediction is that the spermatophore envelopes of polyandrous species with signa will be thicker than those of monandrous species without signa. In agreement with this prediction, we found that the spermatophore envelopes of a polyandrous Heliconius species with signa are thicker than those of two monandrous Heliconius species without signa. The second prediction is that in some species with signa males could enforce monandry in females by evolving “very thick” spermatophore envelopes, in these species we predict that their spermatophore envelopes will be thicker than those of their closer polyandrous relatives with signa. In agreement with this prediction, we found that in two out of three comparisons, spermatophore envelopes of monandrous species with signa have thicker spermatophore envelopes than their closer polyandrous relatives with signa. Thus, our

  10. Sexual coevolution of spermatophore envelopes and female genital traits in butterflies: Evidence of male coercion?

    Science.gov (United States)

    Sánchez, Víctor

    2014-01-01

    Signa are sclerotized structures located on the inner wall of the corpus bursa of female Lepidoptera whose main function is tearing open spermatophores. The sexually antagonistic coevolution (SAC) hypothesis proposes that the thickness of spermatophore envelopes has driven the evolution of the females signa; this idea is based in the fact that in many lepidopterans female sexual receptivity is at least partially controlled by the volume of ejaculate remaining in the corpus bursa. According to the SAC hypothesis, males evolved thick spermatophore envelopes to delay the post-mating recovery of female sexual receptivity thus reducing sperm competition; in response, females evolved signa for breaking spermatophore envelopes faster, gaining access to the resources contained in them and reducing their intermating intervals; the evolution of signa, in turn, favored the evolution of even thicker spermatophore envelopes, and so on. We tested two predictions of the SAC hypothesis with comparative data on the thickness of spermatophore envelopes of eleven species of Heliconiinae butterflies. The first prediction is that the spermatophore envelopes of polyandrous species with signa will be thicker than those of monandrous species without signa. In agreement with this prediction, we found that the spermatophore envelopes of a polyandrous Heliconius species with signa are thicker than those of two monandrous Heliconius species without signa. The second prediction is that in some species with signa males could enforce monandry in females by evolving “very thick” spermatophore envelopes, in these species we predict that their spermatophore envelopes will be thicker than those of their closer polyandrous relatives with signa. In agreement with this prediction, we found that in two out of three comparisons, spermatophore envelopes of monandrous species with signa have thicker spermatophore envelopes than their closer polyandrous relatives with signa. Thus, our results support

  11. Does bilingualism twist your tongue?

    Science.gov (United States)

    Gollan, Tamar H; Goldrick, Matthew

    2012-12-01

    The current study investigated whether bilingualism affects the processing of sub-lexical representations specifying the sound structure of words. Spanish-English bilinguals, Mandarin-English bilinguals, and English-only monolinguals repeated English tongue twisters. Twister materials had word or nonword targets (thus varying in whether lexical information did or did not support sound processing), and similar or dissimilar sounds (thus varying in difficulty with respect to competition at a sub-lexical level). Even though bilinguals had learned English at an early age, and spoke English without an accent, Spanish-English bilinguals produced significantly more twister errors than monolinguals, particularly in the absence of lexical support. Mandarin-English bilinguals were also disadvantaged, but more consistently across all twister types. These results reveal that bilingual disadvantages extend beyond the lexical level to affect the processing of sub-lexical representations. More generally, these findings suggest that experience with sound structures (and not simply their intrinsic complexity) shapes sub-lexical processing for all speakers.

  12. Performance profiles of exterior fire protective building envelopes

    Directory of Open Access Journals (Sweden)

    Jarnskjold Tobias

    2016-01-01

    Full Text Available The fire protective envelope of any building consists of multiple elements with widely differing properties relating to a fire, such as glass, roof tiles and sheathings, wood cladding, gaps and openings. Where resistance to an exterior fire is required, all elements should be verified to provide a comparable risk of burn-through. Elements are rated by either the material response to fire or fire resistance. In Europe, cladding sheets and wall membranes can be rated by K classes, which effectively include a measure of the time to burn through. A determination of burn-through time of each element of a specific building envelope should be obtained. A design tool to verify the performance of a building's fire protective envelope has been developed. In this paper, a general description of passive elements of the envelope, which should be included in a risk assessment tool such as an index method, is presented. An illustrative approach to visualise the profiles for areas densely spaced structures where an exterior fire may trigger building-to-building fire spread is also included. The research is based on the hypothesis that a relatively subtle and pointed upgrading of an exterior building envelope will severely reduce the speed of building-to-building fire spread, thus allowing firefighting efforts to get on top of the situation. For a burning structure to expose other buildings to fire, the fire has to settle, which leads to a burn-through to the inside. Once inside, an enclosure fire needs to develop and burn through the roof or break one or more large window panes. It is estimated that a 5–10 min delay for a structure to expose other structures to fire can be sufficient to avoid loss of multiple structures. A 10–50 min burn-through time allows for an extended intervention by the fire brigade, which is significant in rural areas. A fire protective envelope may prevent an exterior fire from penetrating the protective envelope at all and the

  13. FILAMENTARY STAR FORMATION: OBSERVING THE EVOLUTION TOWARD FLATTENED ENVELOPES

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Katherine; Looney, Leslie [Department of Astronomy, University of Illinois at Urbana-Champaign, 1002 West Green St, Urbana, IL 61801 (United States); Johnstone, Doug [Department of Physics and Astronomy, University of Victoria, P.O. Box 3055, STN CSC, Victoria, BC V8W 3P6 (Canada); Tobin, John, E-mail: ijlee9@illinois.edu, E-mail: lwl@illinois.edu, E-mail: Douglas.Johnstone@nrc-cnrc.gc.ca, E-mail: jtobin@nrao.edu [National Radio Astronomy Observatory, Charlottesville, VA 22903 (United States)

    2012-12-20

    Filamentary structures are ubiquitous from large-scale molecular clouds (a few parsecs) to small-scale circumstellar envelopes around Class 0 sources ({approx}1000 AU to {approx}0.1 pc). In particular, recent observations with the Herschel Space Observatory emphasize the importance of large-scale filaments (a few parsecs) and star formation. The small-scale flattened envelopes around Class 0 sources are reminiscent of the large-scale filaments. We propose an observationally derived scenario for filamentary star formation that describes the evolution of filaments as part of the process for formation of cores and circumstellar envelopes. If such a scenario is correct, small-scale filamentary structures (0.1 pc in length) with higher densities embedded in starless cores should exist, although to date almost all the interferometers have failed to observe such structures. We perform synthetic observations of filaments at the prestellar stage by modeling the known Class 0 flattened envelope in L1157 using both the Combined Array for Research in Millimeter-wave Astronomy (CARMA) and the Atacama Large Millimeter/Submillimeter Array (ALMA). We show that with reasonable estimates for the column density through the flattened envelope, the CARMA D array at 3 mm wavelengths is not able to detect such filamentary structure, so previous studies would not have detected them. However, the substructures may be detected with the CARMA D+E array at 3 mm and the CARMA E array at 1 mm as a result of more appropriate resolution and sensitivity. ALMA is also capable of detecting the substructures and showing the structures in detail compared to the CARMA results with its unprecedented sensitivity. Such detection will confirm the new proposed paradigm of non-spherical star formation.

  14. Effect of DNA Hairpin Loops on the Twist of Planar DNA Origami Tiles

    Science.gov (United States)

    Li, Zhe; Wang, Lei; Yan, Hao; Liu, Yan

    2012-01-01

    The development of scaffolded DNA origami, a technique in which a long single-stranded viral genome is folded into arbitrary shapes by hundreds of short synthetic oligonucleotides, represents an important milestone in DNA nanotechnology. Recent findings have revealed that two-dimensional (2D)DNA origami structures based on the original design parameters adopt a global twist with respect to the tile plane, which may be because the conformation of the constituent DNA (10.67 bp/turn) deviates from the natural B-type helical twist (10.4 bp/turn). Here we aim to characterize the effects of DNA hairpin loops on the overall curvature of the tile and explore their ability to control, and ultimately eliminate any unwanted curvature. A series of dumbbell-shaped DNA loops were selectively displayed on the surface of DNA origami tiles with the expectation that repulsive interactions among the neighboring dumbbell loops and between the loops and the DNA origami tile would influence the structural features of the underlying tiles. A systematic, atomic force microscopy (AFM) study of how the number and position of the DNA loops influenced the global twist of the structure was performed, and several structural models to explain the results were proposed. The observations unambiguously revealed that the first generation of rectangular shaped origami tiles adopt a conformation in which the upper right (corner 2) and bottom left (corner 4) corners bend upward out of the plane, causing linear superstructures attached by these corners to form twisted ribbons. Our experimental observations are consistent with the twist model predicted by the DNA mechanical property simulation software CanDo. Through the systematic design and organization of various numbers of dumbbell loops on both surfaces of the tile, a nearly planar rectangular origami tile was achieved. PMID:22126326

  15. Design optimization for active twist rotor blades

    Science.gov (United States)

    Mok, Ji Won

    This dissertation introduces the process of optimizing active twist rotor blades in the presence of embedded anisotropic piezo-composite actuators. Optimum design of active twist blades is a complex task, since it involves a rich design space with tightly coupled design variables. The study presents the development of an optimization framework for active helicopter rotor blade cross-sectional design. This optimization framework allows for exploring a rich and highly nonlinear design space in order to optimize the active twist rotor blades. Different analytical components are combined in the framework: cross-sectional analysis (UM/VABS), an automated mesh generator, a beam solver (DYMORE), a three-dimensional local strain recovery module, and a gradient based optimizer within MATLAB. Through the mathematical optimization problem, the static twist actuation performance of a blade is maximized while satisfying a series of blade constraints. These constraints are associated with locations of the center of gravity and elastic axis, blade mass per unit span, fundamental rotating blade frequencies, and the blade strength based on local three-dimensional strain fields under worst loading conditions. Through pre-processing, limitations of the proposed process have been studied. When limitations were detected, resolution strategies were proposed. These include mesh overlapping, element distortion, trailing edge tab modeling, electrode modeling and foam implementation of the mesh generator, and the initial point sensibility of the current optimization scheme. Examples demonstrate the effectiveness of this process. Optimization studies were performed on the NASA/Army/MIT ATR blade case. Even though that design was built and shown significant impact in vibration reduction, the proposed optimization process showed that the design could be improved significantly. The second example, based on a model scale of the AH-64D Apache blade, emphasized the capability of this framework to

  16. Instabilities in the Envelopes and Winds of Very Massive Stars

    CERN Document Server

    Owocki, Stanley P

    2014-01-01

    The high luminosity of Very Massive Stars (VMS) means that radiative forces play an important, dynamical role both in the structure and stability of their stellar envelope, and in driving strong stellar-wind mass loss. Focusing on the interplay of radiative flux and opacity, with emphasis on key distinctions between continuum vs. line opacity, this chapter reviews instabilities in the envelopes and winds of VMS. Specifically, we discuss how: 1) the iron opacity bump can induce an extensive inflation of the stellar envelope; 2) the density dependence of mean opacity leads to strange mode instabilities in the outer envelope; 3) desaturation of line-opacity by acceleration of near-surface layers initiates and sustains a line-driven stellar wind outflow; 4) an associated line-deshadowing instability leads to extensive small-scale structure in the outer regions of such line-driven winds; 5) a star with super-Eddington luminosity can develop extensive atmospheric structure from photon bubble instabilities, or from ...

  17. Acute mechano-electronic responses in twisted phosphorene nanoribbons

    Science.gov (United States)

    Jang, Woosun; Kang, Kisung; Soon, Aloysius

    2016-08-01

    Many different forms of mechanical and structural deformations have been employed to alter the electronic structure of various modern two-dimensional (2D) nanomaterials. Given the recent interest in the new class of 2D nanomaterials - phosphorene, here we investigate how the rotational strain-dependent electronic properties of low-dimensional phosphorene may be exploited for technological gain. Here, using first-principles density-functional theory, we investigate the mechanical stability of twisted one-dimensional phosphorene nanoribbons (TPNR) by measuring their critical twist angle (θc) and shear modulus as a function of the applied mechanical torque. We find a strong anisotropic, chirality-dependent mechano-electronic response in the hydrogen-passivated TPNRs upon vortical deformation, resulting in a striking difference in the change in the carrier effective mass as a function of torque angle (and thus, the corresponding change in carrier mobility) between the zigzag and armchair directions in these TPNRs. The accompanied tunable band-gap energies for the hydrogen-passivated zigzag TPNRs may then be exploited for various key opto-electronic nanodevices.Many different forms of mechanical and structural deformations have been employed to alter the electronic structure of various modern two-dimensional (2D) nanomaterials. Given the recent interest in the new class of 2D nanomaterials - phosphorene, here we investigate how the rotational strain-dependent electronic properties of low-dimensional phosphorene may be exploited for technological gain. Here, using first-principles density-functional theory, we investigate the mechanical stability of twisted one-dimensional phosphorene nanoribbons (TPNR) by measuring their critical twist angle (θc) and shear modulus as a function of the applied mechanical torque. We find a strong anisotropic, chirality-dependent mechano-electronic response in the hydrogen-passivated TPNRs upon vortical deformation, resulting in a

  18. First principles study and empirical parametrization of twisted bilayer MoS2 based on band-unfolding

    Science.gov (United States)

    Tan, Yaohua; Chen, Fan W.; Ghosh, Avik W.

    2016-09-01

    We explore the band structure and ballistic electron transport in twisted bilayer MoS2 using the density functional theory. The sphagetti like bands are unfolded to generate band structures in the primitive unit cell of the original 2H MoS2 bilayer and projected onto the original bands of an individual layer. The corresponding twist angle dependent bandedges are extracted from the unfolded band structures. Based on a comparison within the same primitive unit cell, an efficient two band effective mass model for indirect ΓV and ΛC valleys is created and parametrized by fitting to the unfolded band structures. With the two band effective mass model, we calculate transport properties—specifically, the ballistic transmission in arbitrarily twisted bilayer MoS2 .

  19. Introducing the Adaptive Convex Enveloping

    CERN Document Server

    Yu, Sheng

    2011-01-01

    Convexity, though extremely important in mathematical programming, has not drawn enough attention in the field of dynamic programming. This paper gives conditions for verifying convexity of the cost-to-go functions, and introduces an accurate, fast and reliable algorithm for solving convex dynamic programs with multivariate continuous states and actions, called Adaptive Convex Enveloping. This is a short introduction of the core technique created and used in my dissertation, so it is less formal, and misses some parts, such as literature review and reference, compared to a full journal paper.

  20. Expression of Twist Gene in Primary Liver Cancer

    Institute of Scientific and Technical Information of China (English)

    XU Jing; CHEN Xiaoping

    2007-01-01

    In order to investigate the possibility of overexpression of Twist in primary liver cancer (PLC), the Twist expression was detected by using immunohistochemical analysis and RT-PCR assay in 45 patients with PLC. Control tissues were obtained from 9 patients with liver hemangioma. It was found that in 36 (80.0%) out of 45 PLC patients, cancerous regions showed positive cytoplasm and nucleus staining for Twist with a diffuse pattern. In noncancerous adjacent areas and control liver tissues, the expression of Twist was 57.8% and 22.2% respectively. The results of RT-PCR assay re- vealed that the expression of Twist was stronger in the cancerous tissues than that in the noncancer- ous adjacent tissues. It was suggested that the expression of Twist was up-regulated in PLC, which play an important role in the progression of PLC.

  1. MEPPitope: spatial, electrostatic and secondary structure perturbations in the post-fusion Dengue virus envelope protein highlights known epitopes and conserved residues in the Zika virus [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Sandeep Chakraborty

    2016-06-01

    Full Text Available The dramatic transformation of the Zika virus (ZIKV from a relatively unknown virus to a pathogen generating global-wide panic has exposed the dearth of detailed knowledge about this virus. Decades of research in the related Dengue virus (DENV, finally culminating in a vaccine registered for use in endemic regions (CYD-TDV, provides key insights in developing strategies for tackling ZIKV. The previously established MEPP methodology compares two conformations of the same protein and identifies residues with significant spatial and electrostatic perturbations. In the current work, MEPP analyzed the pre-and post-fusion DENV type 2 envelope (E protein, and identified several known epitopes (His317, Tyr299, Glu26, Arg188, etc. (MEPPitope. These residues are overwhelmingly conserved in ZIKV and all DENV serotypes. Characterization of α-helices in E-proteins show that α1 is not conserved in the sequence space of ZIKV and DENV. Furthermore, perturbation of α1 in the post-fusion DENV structure includes a known epitope Asp215, a residue absent in the pre-fusion α1. A cationic β-sheet in the GAG-binding domain that is stereochemically equivalent in ZIKV and all DENV serotypes is also highlighted due to a residue pair (Arg286-Arg288 that has a significant electrostatic polarity reversal upon fusion. Finally, two highly conserved residues (Thr32 and Thr40, with little emphasis in existing literature, are found to have significant electrostatic perturbation. Thus, a combination of different computational methods enable the rapid and rational detection of critical residues that can be made the target of small drugs, or as epitopes in the search for an elusive therapy or vaccine that neutralizes multiple members of the Flaviviridae family.

  2. Integrated Energy Design of the Building Envelope

    DEFF Research Database (Denmark)

    Nielsen, Martin Vraa

    project analysed how the implementation of technical knowledge early in the building design process can quantify the effect of a building’s façades on its energy efficiency and indoor climate and thereby facilitate a more qualified design development. The project was structured in the following way: 1......This thesis describes the outcome of the PhD project Integrated energy design of the building envelope carried out through a combination of scientific dissemination reported through peer-reviewed journals and a wide range of affiliated projects involved in at an architectural firm. The research...... layout, window geometry and transparency, design of the window aperture, etc. Through the wide range of affiliated project involved in at the architectural firm over the course of this project, this approach resulted in building designs with an energy demand at least 25% below the minimum requirements...

  3. Enveloping branes and brane-world singularities

    Energy Technology Data Exchange (ETDEWEB)

    Antoniadis, Ignatios; Cotsakis, Spiros [CERN-Theory Division, Department of Physics, Geneva 23 (Switzerland); Klaoudatou, Ifigeneia [University of the Aegean, Research Group of Geometry, Dynamical Systems and Cosmology, Department of Information and Communication Systems Engineering, Samos (Greece)

    2014-12-01

    The existence of envelopes is studied for systems of differential equations in connection with the method of asymptotic splittings which allows one to determine the singularity structure of the solutions. The result is applied to brane-worlds consisting of a 3-brane in a five-dimensional bulk, in the presence of an analog of a bulk perfect fluid parameterizing a generic class of bulk matter. We find that all flat brane solutions suffer from a finite-distance singularity contrary to previous claims. We then study the possibility of avoiding finite-distance singularities by cutting the bulk and gluing regular solutions at the position of the brane. Further imposing physical conditions such as finite Planck mass on the brane and positive energy conditions on the bulk fluid, excludes, however, this possibility as well. (orig.)

  4. Twisted exponential sums of polynomials in one variable

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The twisted T-adic exponential sums associated to a polynomial in one variable are studied.An explicit arithmetic polygon in terms of the highest two exponents of the polynomial is proved to be a lower bound of the Newton polygon of the C-function of the twisted T-adic exponential sums.This bound gives lower bounds for the Newton polygon of the L-function of twisted p-power order exponential sums.

  5. Negative Regulatory Role of TWIST1 on SNAIL Gene Expression.

    Science.gov (United States)

    Forghanifard, Mohammad Mahdi; Ardalan Khales, Sima; Farshchian, Moein; Rad, Abolfazl; Homayouni-Tabrizi, Masoud; Abbaszadegan, Mohammad Reza

    2017-01-01

    Epithelial-mesenchymal transition (EMT) is crucial for specific morphogenetic movements during embryonic development as well as pathological processes of tumor cell invasion and metastasis. TWIST and SNAIL play vital roles in both developmental and pathological EMT. Our aim in this study was to investigate the functional correlation between TWIST1 and SNAIL in human ESCC cell line (KYSE-30). The packaging cell line GP293T was cotransfected with either control retroviral pruf-IRES-GFP plasmid or pruf-IRES-GFP-hTWIST1 and pGP plasmid. The KYSE-30 ESCC cells were transduced with produced viral particles and examined with inverted fluorescence microscope. DNA was extracted from transduced KYSE-30 cells and analyzed for copy number of integrated retroviral sequences in the target cell genome. The concentration of retroviral particles was determined by Real-time PCR. After RNA extraction and cDNA synthesis, the mRNA expression of TWIST1 and SNAIL was assessed by comparative real-time PCR amplification. Ectopic expression of TWIST1 in KYSE-30, dramatically reduces SNAIL expression. Retroviral transduction enforced TWIST1 overexpression in GFP-hTWIST1 nearly 9 folds in comparison with GFP control cells, and interestingly, this TWIST1 enforced expression caused a - 7 fold decrease of SNAIL mRNA expression in GFP-hTWIST1 compared to GFP control cells. Inverse correlation of TWIST1 and SNAIL mRNA levels may introduce novel molecular gene expression pathway controlling EMT process during ESCC aggressiveness and tumorigenesis. Consequently, these data extend the spectrum of biological activities of TWIST1 and propose that therapeutic repression of TWIST1 may be an effective strategy to inhibit cancer cell invasion and metastasis.

  6. Safeguards Envelope Progress FY10

    Energy Technology Data Exchange (ETDEWEB)

    Richard Metcalf

    2010-10-01

    The Safeguards Envelope is a strategy to determine a set of specific operating parameters within which nuclear facilities may operate to maximize safeguards effectiveness without sacrificing safety or plant efficiency. This paper details the additions to the advanced operating techniques that will be applied to real plant process monitoring (PM) data from the Idaho Chemical Processing Plant (ICPP). Research this year focused on combining disparate pieces of data together to maximize operating time with minimal downtime due to safeguards. A Chi-Square and Croiser's cumulative sum were both included as part of the new analysis. Because of a major issue with the original data, the implementation of the two new tests did not add to the existing set of tests, though limited one-variable optimization made a small increase in detection probability. Additional analysis was performed to determine if prior analysis would have caused a major security or safety operating envelope issue. It was determined that a safety issue would have resulted from the prior research, but that the security may have been increased under certain conditions.

  7. A twist tale of cancer metastasis and tumor angiogenesis.

    Science.gov (United States)

    Tseng, Jen-Chieh; Chen, Hsiao-Fan; Wu, Kou-Juey

    2015-11-01

    Twist1 is an evolutionally conserved transcription factor. Originally identified in Drosophila as a key regulator for mesoderm development, it was later implicated in many human diseases, including Saethre-Chotzen syndrome and cancer. Twist1's involvement in cancer has been well recognized. Driven by hypoxia-induced factor-1 (HIF-1), Twist1 has been considered as a proto-oncogene and its overexpression has been observed in a wide variety of human cancers. High expression level of Twist1 is closely related to tumor aggressiveness and metastatic potential. In cancer cells, Twist1 has been shown to function as a key regulator of epithelial-mesenchymal transition (EMT), a critical process for metastasis initiation. Twist1 has also been implicated in maintaining cancer stemness for self-renewal and chemoresistance. This review first summarizes the roles of Twist1 in embryo development and Saethre-Chotzen syndrome followed by a discussion of Twist1's critical functions in cancer. In particular, the review focuses on the recent discovery of Twist1's capability to promote endothelial transdifferentiation of cancer cells beyond EMT.

  8. Twist1 activity thresholds define multiple functions in limb development

    OpenAIRE

    Krawchuk, Dayana; Weiner, Shoshana J; Chen, You-Tzung; Lu, Benson; Costantini, Frank; Behringer, Richard R.; Laufer, Ed

    2010-01-01

    The basic helix-loop-helix transcription factor Twist1 is essential for normal limb development. Twist1−/− embryos die at midgestation. However, studies on early limb buds found that Twist1−/− mutant limb mesenchyme has an impaired response to FGF signaling from the apical ectodermal ridge, which disrupts the feedback loop between the mesenchyme and AER, and reduces and shifts anteriorly Shh expression in the zone of polarizing activity. We have combined Twist1 null, hypomorph and conditional...

  9. Nematic twist cell: Strong chirality induced at the surfaces

    Science.gov (United States)

    Lin, Tzu-Chieh; Nemitz, Ian R.; Pendery, Joel S.; Schubert, Christopher P. J.; Lemieux, Robert P.; Rosenblatt, Charles

    2013-04-01

    A nematic twist cell having a thickness gradient was filled with a mixture containing a configurationally achiral liquid crystal (LC) and chiral dopant. A chiral-based linear electrooptic effect was observed on application of an ac electric field. This "electroclinic effect" varied monotonically with d, changing sign at d =d0 where the chiral dopant exactly compensated the imposed twist. The results indicate that a significant chiral electrooptic effect always exists near the surfaces of a twist cell containing molecules that can be conformationally deracemized. Additionally, this approach can be used to measure the helical twisting power (HTP) of a chiral dopant in a liquid crystal.

  10. Optical Möbius strips and twisted ribbon cloaks.

    Science.gov (United States)

    Freund, Isaac

    2014-02-15

    Optical Möbius strips that surround points of circular polarization, C points, in a generic three-dimensional optical field are cloaked by lines of twisted ribbons attached to the C points. When cloaking occurs, the observable signed twist index that counts the number of half-twists (one or three), and also measures the handedness (right or left), of a generic Möbius strip is determined by the twisted ribbon cloaks. Although some cloaks can be detached, they can never all be removed.

  11. Twisted rudder for reducing fuel-oil consumption

    Directory of Open Access Journals (Sweden)

    Kim Jung-Hun

    2014-09-01

    Full Text Available Three twisted rudders fit for large container ships have been developed; 1 the Z-twisted rudder that is an asymmetry type taking into consideration incoming flow angles of the propeller slipstream, 2 the ZB-twisted rudder with a rudder bulb added onto the Z-twisted rudder, and 3 the ZB-F twisted rudder with a rudder fin attached to the ZB-twisted rudder. The twisted rudders have been designed computationally with the hydrodynamic characteristics in a self-propulsion condition in mind. The governing equation is the Navier-Stokes equations in an unsteady turbulent flow. The turbulence model applied is the Reynolds stress. The calculation was carried out in towing and self-propulsion conditions. The sliding mesh technique was employed to simulate the flow around the propeller. The speed performances of the ship with the twisted rudders were verified through model tests in a towing tank. The twisted versions showed greater performance driven by increased hull efficiency from less thrust deduction fraction and more effective wake fraction and decreased propeller rotating speed

  12. Finite-dimensional representations of twisted hyper loop algebras

    CERN Document Server

    Bianchi, Angelo

    2012-01-01

    We investigate the category of finite-dimensional representations of twisted hyper loop algebras, i.e., the hyperalgebras associated to twisted loop algebras over finite-dimensional simple Lie algebras. The main results are the classification of the irreducible modules, the definition of the universal highest-weight modules, called the Weyl modules, and, under a certain mild restriction on the characteristic of the ground field, a proof that the simple modules and the Weyl modules for the twisted hyper loop algebras are isomorphic to appropriate simple and Weyl modules for the non-twisted hyper loop algebras, respectively, via restriction of the action.

  13. Modelling of Nonthermal Microwave Emission From Twisted Magnetic Loops

    CERN Document Server

    Sharykin, I N

    2016-01-01

    Microwave gyrosynchrotron radio emission generated by nonthermal electrons in twisted magnetic loops is modelled using the recently developed simulation tool GX Simulator. We consider isotropic and anisotropic pitch-angle distributions. The main scope of the work is to understand impact of the magnetic field twisted topology on resulted radio emission maps. We have found that nonthermal electrons inside twisted magnetic loops produce gyrosynchrotron radio emission with peculiar polarization distribution. The polarization sign inversion line is inclined relatively to the axis of the loop. Radio emission source is more compact in the case of less twisted loop, considering anisotropic pitch-angle distribution of nonthermal electrons.

  14. Adaptive Flight Envelope Estimation and Protection Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Impact Technologies, in collaboration with the Georgia Institute of Technology, proposes to develop and demonstrate an innovative flight envelope estimation and...

  15. Hierarchical Helical Order in the Twisted Growth of Plant Organs

    Science.gov (United States)

    Wada, Hirofumi

    2012-09-01

    The molecular and cellular basis of left-right asymmetry in plant morphogenesis is a fundamental issue in biology. A rapidly elongating root or hypocotyl of twisting mutants of Arabidopsis thaliana exhibits a helical growth with a handedness opposite to that of the underlying cortical microtubule arrays in epidermal cells. However, how such a hierarchical helical order emerges is currently unknown. We propose a model for investigating macroscopic chiral asymmetry in Arabidopsis mutants. Our elastic model suggests that the helical pattern observed is a direct consequence of the simultaneous presence of anisotropic growth and tilting of cortical microtubule arrays. We predict that the root helical pitch angle is a function of the microtubule helical angle and elastic moduli of the tissues. The proposed model is versatile and is potentially important for other biological systems ranging from protein fibrous structures to tree trunks.

  16. Magnetic Plasmon Sensing in Twisted Split-Ring Resonators

    Directory of Open Access Journals (Sweden)

    J. X. Cao

    2012-01-01

    Full Text Available We studied the sensing properties of stereo-SRRs metamaterials composed from two twisted split-ring resonators (SRRs. Due to the strong hybridization effect in the system, the polarization state of the transmitted wave is greatly changed at resonances. Since the stereo-SRRs structure is strongly coupled to the surrounding medium, the polarization change of the transmitted waves is quite sensitive to the refractive index change of the environment medium. The polarization ratio PRtran = Ty/Tx is used as sensing parameter and its figure of merit can reach 22.3 at the hybridized magnetic plasmon resonance. The results showed that the stereo-SRRs metamaterial can be applied to optical sensors an or other related field.

  17. Building Construction Elements, Building Envelope and Method for Constructing a Building Envelope

    DEFF Research Database (Denmark)

    2009-01-01

    High-strength concrete building system and method of assembly for construction a buiding envelope.......High-strength concrete building system and method of assembly for construction a buiding envelope....

  18. Equilibrium shapes of twisted magnetic filaments

    Energy Technology Data Exchange (ETDEWEB)

    Belovs, Mihails; Cirulis, Teodors; Cebers, Andrejs [University of Latvia, Zellu 8, LV-1002 (Latvia)], E-mail: aceb@tesla.sal.lv

    2009-06-12

    It is shown that ferromagnetic filaments with free and unclamped ends undergo buckling instabilities under the action of twist. Solutions of nonlinear equations describing the buckled shapes are found, and it is shown that the transition to the buckled shape is subcritical if the magnetization is parallel to the field and supercritical when the magnetization of the straight filament is opposite to the external field. Solutions with the localized curvature distribution are found in the case of long filaments. The class of solutions corresponding to helices is described, and the behavior of coiled ferromagnetic and superparamagnetic filaments is compared.

  19. Non-destructive identification of twisted light.

    Science.gov (United States)

    Li, Pengyun; Wang, Bo; Song, Xinbing; Zhang, Xiangdong

    2016-04-01

    The non-destructive identification of the orbital angular momentum (OAM) is essential to various applications in the optical information processing. Here, we propose and demonstrate experimentally an efficient method to identify non-destructively the OAM by using a modified Mach-Zehnder interferometer. Our schemes are applicable not only to the case with integer charges, but also to optical vortices with noninteger charges. Our Letter presents the first experimental demonstration of the non-destructive identification of twisted light with integer or noninteger topological charges, which has potential applications in the OAM-based data transmission for optical communications.

  20. Quantum mass correction for the twisted kink

    CERN Document Server

    Pawellek, Michael

    2008-01-01

    We present an analytic result for the 1-loop quantum mass correction in semiclassical quantization for the twisted \\phi^4 kink on S^1 without explicit knowledge of the fluctuation spectrum. For this purpose we use the contour integral representation of the spectral zeta function. By solving the Bethe ansatz equations for the n=2 Lame equation we obtain an analytic expression for the corresponding spectral discriminant. We discuss the renormalization issues of this model. An energetically preferred size for the compact space is finally obtained.