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Sample records for twenty-four hour test

  1. Twenty-Four-Hour Ambulatory Blood Pressure Monitoring in Hypertension

    Science.gov (United States)

    2012-01-01

    Executive Summary Objective The objective of this health technology assessment was to determine the clinical effectiveness and cost-effectiveness of 24-hour ambulatory blood pressure monitoring (ABPM) for hypertension. Clinical Need: Condition and Target Population Hypertension occurs when either systolic blood pressure, the pressure in the artery when the heart contracts, or diastolic blood pressure, the pressure in the artery when the heart relaxes between beats, are consistently high. Blood pressure (BP) that is consistently more than 140/90 mmHg (systolic/diastolic) is considered high. A lower threshold, greater than 130/80 mmHg (systolic/diastolic), is set for individuals with diabetes or chronic kidney disease. In 2006 and 2007, the age-standardized incidence rate of diagnosed hypertension in Canada was 25.8 per 1,000 (450,000 individuals were newly diagnosed). During the same time period, 22.7% of adult Canadians were living with diagnosed hypertension. A smaller proportion of Canadians are unaware they have hypertension; therefore, the estimated number of Canadians affected by this disease may be higher. Diagnosis and management of hypertension are important, since elevated BP levels are related to the risk of cardiovascular disease, including stroke. In Canada in 2003, the costs to the health care system related to the diagnosis, treatment, and management of hypertension were over $2.3 billion (Cdn). Technology The 24-hour ABPM device consists of a standard inflatable cuff attached to a small computer weighing about 500 grams, which is worn over the shoulder or on a belt. The technology is noninvasive and fully automated. The device takes BP measurements every 15 to 30 minutes over a 24-to 28-hour time period, thus providing extended, continuous BP recordings even during a patient’s normal daily activities. Information on the multiple BP measurements can be downloaded to a computer. The main detection methods used by the device are auscultation and

  2. Twenty-four-hour blood pressure among Greenlanders and Danes: relationship to diet and lifestyle

    DEFF Research Database (Denmark)

    Jørgensen, Marit Eika; Pedersen, M.B.; Siggaard, Cecilie

    2002-01-01

    the influence of Arctic food and lifestyle on blood pressure. Four groups of healthy subjects were recruited for the study. Group I: Danes in Denmark consuming European food; group II: Greenlanders in Denmark consuming European food; group III: Greenlanders in Greenland consuming mainly European food; and group......, outdoor temperature, and lifestyle factors. Greenlanders have a lower 24-h diastolic blood pressure than Danes, and it is suggested that genetic factors are mainly responsible for the lower blood pressure level among Greenlanders. Twenty-four-hour blood pressure among Greenlanders and Danes: Relationship...... to diet and lifestyle - ResearchGate. Available from: http://www.researchgate.net/publication/11001663_Twenty-four-hour_blood_pressure_among_Greenlanders_and_Danes_Relationship_to_diet_and_lifestyle [accessed Oct 7, 2015]....

  3. Twenty-four hour Holter monitoring in finishing cattle housed outdoors.

    Science.gov (United States)

    Frese, D A; Thomason, J D; Reinhardt, C; Bartle, S; Rethorst, D; Loneragan, G H; Thomson, D

    2017-04-01

    Atrial premature complexes have been reported to be the most common arrhythmia in cattle and is suspected to be secondary to systemic disease, especially gastrointestinal disease. In order to properly identify pathologic arrhythmia in cattle, the normal rhythm and arrhythmia prevalence should be defined. The objective of this study was to determine the normal heart rate, rhythm, number of ventricular premature complexes (VPCs), and atrial premature complexes (APCs) in unrestrained Angus steers. Twenty-seven client owned steers with unremarkable physical examinations and serum biochemical analyses were used. Twenty-four hour Holter monitors, attached by a custom-made harness, were retrospectively evaluated. Three lead electrocardiographic registrations of good quality and normal sinus rhythm were obtained from all steers in the study. The mean heart rate was 66.8 bpm ± 16.4 bpm. Ventricular premature complexes were rare (noted in 14.8% of steers), and APCs were common (noted in 85% of the steers). Simple second degree AV block was observed in 18.5% of the steers. In summary, healthy steers have rare single VPCs, although it is possible for an individual animal to have apparent more frequent VPCs. Mean heart rate varies with a diurnal pattern similar to other species. Atrial premature complexes are the most prevalent abnormality observed in feedlot steers. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Twenty-Four-Hour Mobility During Acute Hospitalization in Older Medical Patients

    DEFF Research Database (Denmark)

    Pedersen, Mette Merete; Bodilsen, Ann Christine; Petersen, Janne

    2013-01-01

    BACKGROUND: Inactivity during hospitalization in older medical patients may lead to functional decline. This study quantified 24-hour mobility, validated the accelerometers used, and assessed the daily level of basic mobility in acutely admitted older medical patients during their hospitalization...

  5. Twenty-four-hour intraocular pressure patterns in a symptomatic patient after ab interno trabeculotomy surgery

    Directory of Open Access Journals (Sweden)

    Mansouri K

    2014-11-01

    Full Text Available Kaweh Mansouri,1 Felipe A Medeiros,2 Robert N Weinreb2 1Glaucoma Sector, Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland; 2Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA Abstract: We report the results of repeated ambulatory continuous 24-hour intraocular pressure (IOP monitoring with a contact lens sensor (CLS in a glaucoma patient with ocular pain after ab interno trabeculotomy (Trabectome™ surgery. Our findings show that a combined prostaglandin–pilocarpine treatment reduced nighttime IOP peaks and relieved the patient’s symptoms. Keywords: 24-hour, Trabectome contact lens sensor, prostaglandin–pilocarpine treatment

  6. Twenty-four hour blood flow in the forefoot after reconstructive vascular surgery

    Energy Technology Data Exchange (ETDEWEB)

    Jelnes, R.

    1986-08-01

    Local blood flow in the forefoot (SBF) was measured continuously during 24 hours by 133xenon clearance technique in 10 patients prior to and at least 1 year after successful reconstructive vascular surgery for severe arterial insufficiency (mean: 18 months, range: 12-36). A group of 10 patients with normal peripheral circulation served as a control group. In spite of a considerable increase of the ankle/arm systolic blood pressure index--preoperative: 0.30 +/- 0.12, postoperative: 0.78 +/- 0.28 (mean +/- 1 SD)--the SBF decreased by 50% (p less than 0.001) following reconstructive vascular surgery during day activities. During sleep, however, SBF increased by 80% (p less than 0.001). The relative changes in SBF from day to night at the postoperative examination did not differ from that of the control group, i.e., the normal 24-hour blood flow pattern had been obtained. These changes in SBF are explained by the reappearance of peripheral vasoregulatory mechanisms. Postreconstructive hyperemia was evaluated by the same technique. The changes in SBF following surgery in the positions supine, awake and supine, asleep were found to be insignificant (0.80 less than p less than 0.90). It is concluded that the long-term postreconstructive hyperemia merely is a reflection of the normal 24-hour blood flow pattern.

  7. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing.

    Science.gov (United States)

    Amin, Raouf S; Carroll, John L; Jeffries, Jenny L; Grone, Charles; Bean, Judy A; Chini, Barbara; Bokulic, Ronald; Daniels, Stephen R

    2004-04-15

    Obstructive sleep apnea causes intermittent elevation of systemic blood pressure (BP) during sleep. To determine whether obstructive apnea in children has a tonic effect on diurnal BP, 24-hour ambulatory blood pressure was obtained from 60 children with mean age of 10.8 +/- 3.5 years. Thirty-nine children had obstructive apnea and 21 had primary snoring. Children with obstructive apnea had significantly greater mean BP variability during wakefulness and sleep, a higher night-to-day systolic BP, and a smaller nocturnal dipping of mean BP. Variability of mean arterial pressure during wakefulness was predicted by the desaturation, body mass, and arousal indices, whereas variability during sleep was predicted by apnea-hypopnea and body mass indices. Nocturnal BP dipping was predicted by the desaturation index. There were no significant differences in systolic, diastolic, or mean arterial BP during sleep between the groups. Diastolic BP during wakefulness was significantly different between the groups and correlated negatively with apnea-hypopnea index. We conclude that obstructive apnea in children is associated with 24-hour BP dysregulation and that, independent of obesity, the frequency of obstructive apnea, oxygen desaturation, and arousal contributes to abnormal BP control.

  8. Twenty-four hour blood flow in the forefoot after reconstructive vascular surgery

    DEFF Research Database (Denmark)

    Jelnes, R

    1986-01-01

    Local blood flow in the forefoot (SBF) was measured continuously during 24 hours by 133xenon clearance technique in 10 patients prior to and at least 1 year after successful reconstructive vascular surgery for severe arterial insufficiency (mean: 18 months, range: 12-36). A group of 10 patients...... with normal peripheral circulation served as a control group. In spite of a considerable increase of the ankle/arm systolic blood pressure index--preoperative: 0.30 +/- 0.12, postoperative: 0.78 +/- 0.28 (mean +/- 1 SD)--the SBF decreased by 50% (p less than 0.001) following reconstructive vascular surgery...... are explained by the reappearance of peripheral vasoregulatory mechanisms. Postreconstructive hyperemia was evaluated by the same technique. The changes in SBF following surgery in the positions supine, awake and supine, asleep were found to be insignificant (0.80 less than p less than 0.90). It is concluded...

  9. Twenty-four-hour esophageal pH monitoring in children and adolescents with chronic and/or recurrent rhinosinusitis

    Directory of Open Access Journals (Sweden)

    V.R.S.G. Monteiro

    2005-02-01

    Full Text Available Gastroesophageal reflux (GER disorder was studied in children and adolescents with chronic and/or recurrent rhinosinusitis not associated with bronchial asthma. Ten children with a clinical and radiological diagnosis of chronic and/or recurrent rhinosinusitis, consecutively attended at the Pediatric Otolaryngology Outpatient Clinic, Federal University of São Paulo, were evaluated. Prolonged esophageal pH monitoring was used to investigate GER disorder. The mean age of the ten patients evaluated (eight males was 7.4 ± 2.4 years. Two patients presented vomiting as a clinical manifestation and one patient presented retrosternal pain with a burning sensation. Twenty-four-hour esophageal pH monitoring was performed using the Sandhill apparatus. An antimony probe electrode was placed in the lower third of the esophagus, confirmed by fluoroscopy and later by a chest X-ray. The parameters analyzed by esophageal pH monitoring included: total percent time of the presence of acid esophageal pH, i.e., pH below 4 (<4.2%; total number of acid episodes (<50 episodes; number of reflux episodes longer than 5 min (3 or less, and duration of the longest reflux episode (<9.2 min. One patient (1/10, 10% presented a 24-h esophageal pH profile compatible with GER disorder. This data suggest that an association between chronic rhinosinusitis not associated with bronchial asthma and GER disorder may exist in children and adolescents, especially in those with compatible GER disorder symptoms. In these cases, 24-h esophageal pH monitoring should be performed before indicating surgery, since the present data suggest that 10% of chronic rhinosinusitis surgeries can be eliminated.

  10. Prevalence of type 1 brugada electrocardiographic pattern evaluated by twelve-lead twenty-four-hour holter monitoring.

    Science.gov (United States)

    Cerrato, Natascia; Giustetto, Carla; Gribaudo, Elena; Richiardi, Elena; Barbonaglia, Lorella; Scrocco, Chiara; Zema, Domenica; Gaita, Fiorenzo

    2015-01-01

    Patients with drug-induced type 1 Brugada electrocardiograms (BrECGs) are considered to have good prognosis. Spontaneous type 1 is, instead, considered a risk factor; however, it is probably underestimated because of the BrECG fluctuations. The aim of this study was to analyze, in a large population of patients with Br, the real prevalence of type 1 BrECG using 12-lead 24-hour Holter monitoring (12L-Holter) and its correlation with the time of the day. We recorded 303 12L-Holter in 251 patients. Seventy-five (30%) patients exhibited spontaneous type 1 BrECG at 12-lead ECG (group 1) and 176 (70%) had only drug-induced type 1 (group 2). Type 1 BrECG was defined as "persistent" (>85% of the recording), "intermittent" (Holter, 57% intermittent type 1%, and 31% never had type 1; in group 2, none had persistent type 1, 20% had intermittent type 1%, and 80% never showed type 1. To evaluate the circadian fluctuations of BrECG, 4 periods in the day were considered. Type 1 BrECG was more frequent between 12-noon and 6 p.m. (52%, p Holter than with conventional follow-up with periodic ECGs and this has important implications in the risk stratification. 12L-Holter recording might avoid 20% of the pharmacological challenges with sodium channel blockers, which are not without risks, and should thus be considered as the first screening test, particularly in children or in presence of borderline diagnostic basal ECG.

  11. Twenty-Four-Hour Urinary Aldosterone Predicts Inappropriate Left Ventricular Mass Index in Patients with Primary Aldosteronism

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    Chi-Sheng Hung

    2013-01-01

    Full Text Available Objective. Primary aldosteronism (PA is associated with inappropriate left ventricular hypertrophy (LVH in relation to a given gender and body size. There is no ideal parameter to predict the presence of LVH or inappropriate LVH in patients with PA. We investigate the performance of 24-hour urinary aldosterone level, plasma renin activity and aldosterone-to-renin ratio on this task. Methods. We performed echocardiography in 106 patients with PA and 31 subjects with essential hypertension (EH in a tertiary teaching hospital. Plasma renin activity, aldosterone concentration, and 24-hour urinary aldosterone level were measured. Results. Only 24-hour urinary aldosterone was correlated with left ventricular mass index (LVMI and excess LVMI among these parameters. The multivariate analysis revealed the urinary aldosterone level as an independent predictor for LVMI and excess LVMI. Analyzing the ability of urinary aldosterone, plasma aldosterone concentration, and plasma aldosterone-to-renin ratio to identify the presence of LVH (ROC AUC = 0.701, 0.568, 0.656, resp. and the presence of inappropriate LV mass index (defined as measured LVMI in predicting LVMI ratio >135% (ROC area under curve = 0.61, 0.43, 0.493, resp. revealed the better performance of 24-hour urinary aldosterone. Conclusions. In conclusion, 24-hour urinary aldosterone level performed better to predict the presence of LVH and inappropriate LVMI in patients with PA.

  12. The Twenty-four Hour Workday: Proceedings of a Symposium on Variations in Work-Sleep Schedules

    Science.gov (United States)

    1980-10-01

    Md. Tray.: 1971, _j 393-395. .ndlauer,P., Carpentier,J., & Cazamian,P. (Eds.). Ergonomie du travail de nuit et des horaires alternants. Education...and between subjects and suggest that Gaillard’s conclusion may not -be true. 743 REM 0) 2 {3 i4 40[ REM E 0L ɘ U 730-Delta Hour !Igure :2. Comuter

  13. Twenty-four-hour profiles of metabolic and stress hormones in sheep selected for a calm or nervous temperament.

    Science.gov (United States)

    Rietema, S E; Blackberry, M A; Maloney, S K; Martin, G B; Hawken, P A R; Blache, D

    2015-10-01

    Even in the absence of stressors, temperament is associated with changes in the concentration of stress-responsive hormones and, possibly because of such changes, temperament can affect metabolism. We tested whether, in sheep bred for temperament for 14 generations, "nervous" females have greater concentrations of stress-responsive hormones in the absence of stressors than "calm" females, and whether these differences are associated with changes in the concentrations of metabolic hormones. In resting "calm" (n = 8) and "nervous" (n = 8) sheep, concentrations of cortisol, prolactin, leptin, and insulin were measured in blood plasma sampled via jugular catheter every 20 min for 24 h. The animals were individually penned, habituated to their housing and human handling over 7 wk, and fed before sampling began. Diurnal variation was evident for all hormones, but a 24-h cortisol pattern was detected in only 7 individuals. There was no effect of temperament on any aspect of concentrations of cortisol or prolactin, but "calm" animals had greater concentrations of insulin in the early afternoon than "nervous" animals (14.5 ± 1.1 vs 10.0 ± 1.6 μU/mL; P = 0.038), and a similar tendency was seen for leptin (P = 0.092). We conclude that selection for temperament affects the concentration of metabolic hormones in the absence of stressors, but this effect is independent of stress-responsive hormones.

  14. Twenty-four-hour urine constituents in stone formers: A study from the northeast part of Peninsular Malaysia

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    N S Hussein

    2013-01-01

    Full Text Available Urolithiasis is a common disease with increasing incidence and prevalence world-wide, probably more common in industrialized countries. The metabolic evaluation of 24-h urine collection has been considered as part of the management of urinary stone patients. The aim of this study was to evaluate the 24-h urine constituents in stone formers and its relation to demographic data in the northeast part of Peninsular Malaysia. One hundred and six patients were recruited in this study from two hospitals in the same geographical region; 96 patients fulfilled the inclusion criteria and an informed consent was obtained from all subjects. The 24-h urine was collected in sterile bottles with a preservative agent and calcium, oxalate, citrate, uric acid, magnesium and phosphate were tested using commercial kits on a Roche Hitachi 912 chemistry analyzer. The age (mean ± SD of 96 patients was 56.45 ± 13.43 years and 82.3% of the patients were male while 17.7% were female. The 24-h urine abnormalities were hypercalciuria (14.5%, hyperoxaluria (61.4%, hypocitraturia (57.2%, hyperuricouria (19.7%, hypomagnesuria (59.3% and hyperphosphaturia (12.5%. Hyperoxaluria (61.4% was the most common abnormality detected during the analysis of 24-h urine constituents in contradiction to industrial countries, where hypercalciuria was the most common finding. The high frequencies of hypomagnesuria and hypocitraturia reflect the important role of magnesium and citrate in stone formation and their prophylactic role in the treatment of urinary stone disease in the given population.

  15. Twenty-four-hour urine constituents in stone formers: a study from the northeast part of Peninsular Malaysia.

    Science.gov (United States)

    Hussein, N S; Sadiq, S M; Kamaliah, M D; Norakmal, A W; Gohar, M N

    2013-05-01

    Urolithiasis is a common disease with increasing incidence and prevalence world-wide, probably more common in industrialized countries. The metabolic evaluation of 24-h urine collection has been considered as part of the management of urinary stone patients. The aim of this study was to evaluate the 24-h urine constituents in stone formers and its relation to demographic data in the northeast part of Peninsular Malaysia. One hundred and six patients were recruited in this study from two hospitals in the same geographical region; 96 patients fulfilled the inclusion criteria and an informed consent was obtained from all subjects. The 24-h urine was collected in sterile bottles with a preservative agent and calcium, oxalate, citrate, uric acid, magnesium and phosphate were tested using commercial kits on a Roche Hitachi 912 chemistry analyzer. The age (mean ± SD) of 96 patients was 56.45 ± 13.43 years and 82.3% of the patients were male while 17.7% were female. The 24-h urine abnormalities were hypercalciuria (14.5%), hyperoxaluria (61.4%), hypocitraturia (57.2%), hyperuricouria (19.7%), hypomagnesuria (59.3%) and hyperphosphaturia (12.5%). Hyperoxaluria (61.4%) was the most common abnormality detected during the analysis of 24-h urine constituents in contradiction to industrial countries, where hypercalciuria was the most common finding. The high frequencies of hypomagnesuria and hypocitraturia reflect the important role of magnesium and citrate in stone formation and their prophylactic role in the treatment of urinary stone disease in the given population.

  16. [Changes of twenty-four-hour profile blood pressure and its correction of patients with arterial hypertension on the background of combined antihypertensive therapy application].

    Science.gov (United States)

    Solomennchuk, T M; Slaba, N A; Prots'ko, V V; Bedzaĭ, A O

    2014-01-01

    The aim of this research was the study of efficiency and endurance antihypertensive therapy on the basis of fixed combination of enalapril and hydrochlorothiazide (HCTZ) and enalapril and HCTZ in combination with amlodipine according to the twenty-four-hour (? day-and-night) monitoring of blood pressure (? 24H BPM) of patients with arterial hypertension (AH) 2-3 severity. The study included 33 patients with 2-3 grade of hypertension (average age--54,40 ± 3.45 years). All patients performed ? 24H BPM before treatment and after 12 weeks of therapy. The combination of enalapril and HCTZ allowed to achieve target levels of blood pressure in 79% of patients, amlodipine additional purpose--in 86% of patients. We found that this therapy has a corrective effect on daily blood pressure profile, significantly reducing the load pressure and blood pressure variability. During treatment with the combination of enalapril and HCTZ combination of enalapril, HCTZ with amlodipine optimal daily profile of blood pressure after 12 weeks of reaching respectively 63.1% and 71.4% of patients. The treatment with combination of enalapril and HCTZ and adding of amlodipine is characterized by good endurance and high adherence to treatment.

  17. Twenty-four-hour Tl-201 delayed scan underestimates myocardial viability in patients with acute myocardial infarction after percutaneous transluminal coronary angioplasty

    Energy Technology Data Exchange (ETDEWEB)

    Mochizuki, Teruhito; Sugawara, Yoshifumi; Kikuchi, Takanori; Ikezoe, Junpei [Ehime Univ., Matsuyama (Japan). School of Medicine; Murase, Kenya; Higashino, Hiroshi; Miyagawa, Masao

    2001-04-01

    Myocardial viability in area at risk of acute myocardial infarction (AMI) after reperfusion therapy may be underestimated by the 24-hour images due to reverse redistribution (r-RD). Subjects were 37 AMI patients in whom Tc-99m pyrophosphate (PYP)/Tl-201 dual-isotope SPECT was positive. The 24-hour delayed scan was performed with only a Tl window. One month later, follow up rest Tl SPECT was performed to evaluate myocardial viability. In early (at PYP/Tl-201 dual-isotope SPECT), 24-hour, and one month follow up Tl studies, Tl uptake in the area of AMI was scored into four grades: 3 as normal to 0 as severely reduced. The scores were evaluated. Among the 37 AMI lesions, there were 16 r-RD, 3 RD, 16 fixed defect (FD) and 2 normal (positive PYP and normal Tl). Mean Tl scores were early; 1.4{+-}1.1, 24-hr; 0.9{+-}0.9 and one month; 1.3{+-}1.1. The 24-hour Tl score was lower than the early and one month Tl scores (p<0.01). Reverse redistribution is frequently observed in an area at risk where PYP SPECT was positive. Nuclear medicine physicians should be aware of the existence of frequent r-RD in Tl scan to avoid the underestimation of myocardial viability in the acute phase after PTCA. (author)

  18. Twenty-Four-Hour Blood Pressure Monitoring to Predict and Assess Impact of Renal Denervation: The DENERHTN Study (Renal Denervation for Hypertension).

    Science.gov (United States)

    Gosse, Philippe; Cremer, Antoine; Pereira, Helena; Bobrie, Guillaume; Chatellier, Gilles; Chamontin, Bernard; Courand, Pierre-Yves; Delsart, Pascal; Denolle, Thierry; Dourmap, Caroline; Ferrari, Emile; Girerd, Xavier; Michel Halimi, Jean; Herpin, Daniel; Lantelme, Pierre; Monge, Matthieu; Mounier-Vehier, Claire; Mourad, Jean-Jacques; Ormezzano, Olivier; Ribstein, Jean; Rossignol, Patrick; Sapoval, Marc; Vaïsse, Bernard; Zannad, Faiez; Azizi, Michel

    2017-03-01

    The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure (BP) lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report here the effect of denervation on 24-hour BP and its variability and look for parameters that predicted the BP response. Patients with resistant hypertension were randomly assigned to denervation plus stepped-care treatment or treatment alone (control). Average and standard deviation of 24-hour, daytime, and nighttime BP and the smoothness index were calculated on recordings performed at randomization and 6 months. Responders were defined as a 6-month 24-hour systolic BP reduction ≥20 mm Hg. Analyses were performed on the per-protocol population. The significantly greater BP reduction in the denervation group was associated with a higher smoothness index (P=0.02). Variability of 24-hour, daytime, and nighttime BP did not change significantly from baseline to 6 months in both groups. The number of responders was greater in the denervation (20/44, 44.5%) than in the control group (11/53, 20.8%; P=0.01). In the discriminant analysis, baseline average nighttime systolic BP and standard deviation were significant predictors of the systolic BP response in the denervation group only, allowing adequate responder classification of 70% of the patients. Our results show that denervation lowers ambulatory BP homogeneously over 24 hours in patients with resistant hypertension and suggest that nighttime systolic BP and variability are predictors of the BP response to denervation. URL: https://www.clinicaltrials.gov. Unique identifier: NCT01570777. © 2017 American Heart Association, Inc.

  19. The acute effects of twenty-four hours of sleep loss on the performance of national-caliber male collegiate weightlifters.

    Science.gov (United States)

    Blumert, Peter A; Crum, Aaron J; Ernsting, Mark; Volek, Jeff S; Hollander, Daniel B; Haff, Erin E; Haff, G Gregory

    2007-11-01

    Currently, the degree to which sleep loss influences weightlifting performance is unknown. This study compared the effects of 24 hours of sleep loss on weightlifting performance and subjective ratings of psychological states pre-exercise and postexercise in national-caliber male collegiate weightlifters. Nine males performed a maximal weightlifting protocol following 24 hours of sleep loss and a night of normal sleep. The subjects participated in a randomized, counterbalanced design with each sleep condition separated by 7 days. Testosterone and cortisol levels were quantified prior to, immediately after, and 1 hour after the resistance training session. Additionally, profile of mood states and subjective sleepiness were evaluated at the same time points. The resistance training protocol consisted of several sets of snatches, clean and jerks, and front squats. Performance was evaluated as individual exercise volume load, training intensity and overall workout volume load, and training intensity. During each training session the maximum weight lifted for the snatch, clean and jerk, and front squat were noted. No significant differences were found for any of the performance variables. A significant decrease following the sleep condition was noted for cortisol concentration immediately after and 1 hour postexercise. Vigor, fatigue, confusion, total mood disturbance, and sleepiness were all significantly altered by sleep loss. These data suggest that 24 hours of sleep loss has no adverse effects on weightlifting performance. If an athlete is in an acute period of sleep loss, as noticed by negative mood disturbances, it may be more beneficial to focus on the psychological (motivation) rather than the physiological aspect of the sport.

  20. [Twenty-four hour time and frequency domain variability of systolic blood pressure and heart rate in an experimental model of arterial hypertension plus obesity].

    Science.gov (United States)

    Pelat, M; Verwaerde, P; Lazartiques, E; Cabrol, P; Galitzky, J; Berlan, M; Montastruc, J L; Senard, J M

    1998-08-01

    Modifications of heart rate (HR) and systolic blood pressure (SBP) variabilities (V) have been reported in the human syndrome arterial hypertension plus insulin-resistance. The aim of this study was to characterize the 24 h SBPV and HRV in both time and frequency domains during weight increase in dogs fed ad libitum with a high fat diet. Implantable transmitter units for measurement of blood pressure and heart rate were surgically implanted in five beagle male dogs. BP and HR were continuously recorded using telemetric measurements during 24 hours, before and after 6 and 9 weeks of hypercaloric diet in quiet animals submitted to a 12h light-dark cycle. To study nychtemeral cycle of SBP and HR, two periods were chosen: day (from 6.00 h to 19.00 h) and night (from 23.00 h to 6.00 h). Spontaneous baroreflex efficiency was measured using the sequence method. Spectral variability of HR and SBP was analyzed using a fast Fourier transformation on 512 consecutive values and normalized units of low (LF: 50-150 mHz, reflecting sympathetic activity) and high (HF: respiratory rate +/- 50 mHz, reflecting parasympathetic activity) frequency bands were calculated. The energy of total spectrum (from 0.004 to 1 Hz) was also studied. Body weight (12.4 +/- 0.9 vs 14.9 +/- 0.9 kg, p < 0.05). SBP (132 +/- 1 vs 147 +/- 1 mmHg, p < 0.05) significantly increased after 9 weeks of hypercaloric diet. A nycthemeral HR rhythm was present at baseline (day: 79 +/- 1 vs night: 71 +/- 1 bpm) but not after 9 weeks (day: 91 +/- 4 bpm ; night: 86 +/- 2 bpm). Concomitantly, the efficiency of spontaneous baroreflex decreased at 6 weeks (36 +/- 1 vs 42 +/- 2 mmHg/ms, p < 0.05). A significant decrease in HF energy of HRV was found after 6 but not after 9 weeks. LF energy of SBPV was increased at 6 but not at 9 weeks (table). [table: see text] In conclusion, this study shows that an hyperlipidic and hypercaloric diet induces transient variations in autonomic nervous system activity which could be the

  1. Twenty-four-hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction

    DEFF Research Database (Denmark)

    Breum, Leif; Rasmussen, Michael H; Hilsted, Jannik

    2003-01-01

    subjects. Blood samples were drawn frequently throughout the 24-h period. An insulin tolerance test was also used to determine whether weight loss altered the ability of insulin to modify plasma concentrations of tryptophan and of the other large neutral amino acids. RESULTS: Plasma tryptophan......BACKGROUND: Plasma tryptophan concentrations and the ratio of tryptophan to other large neutral amino acids (plasma tryptophan ratio) are reportedly low in obese subjects. The plasma tryptophan ratio predicts brain tryptophan uptake and serotonin production. If this ratio is low in obese subjects...... concentrations and ratios in obese subjects were low at all times; these effects persisted after weight reduction. Plasma concentrations of all the large neutral amino acids decreased during insulin infusion in all the groups. CONCLUSIONS: The low 24-h plasma tryptophan ratios in obese and formerly obese...

  2. Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults

    Science.gov (United States)

    Elvsåshagen, Torbjørn; Zak, Nathalia; Norbom, Linn B.; Pedersen, Per Ø.; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik F.; Groote, Inge R.; Kaufmann, Tobias; Andreassen, Ole A.; Westlye, Lars T.

    2017-01-01

    Heart rate variability (HRV) has become an increasingly popular index of cardiac autonomic control in the biobehavioral sciences due to its relationship with mental illness and cognitive traits. However, the intraindividual stability of HRV in response to sleep and diurnal disturbances, which are commonly reported in mental illness, and its relationship with executive function are not well understood. Here, in 40 healthy adult males we calculated high frequency HRV—an index of parasympathetic nervous system (PNS) activity—using pulse oximetry during brain imaging, and assessed attentional and executive function performance in a subsequent behavioral test session at three time points: morning, evening, and the following morning. Twenty participants were randomly selected for total sleep deprivation whereas the other 20 participants slept as normal. Sleep deprivation and morning-to-night variation did not influence high frequency HRV at either a group or individual level; however, sleep deprivation abolished the relationship between orienting attention performance and HRV. We conclude that a day of wake and a night of laboratory-induced sleep deprivation do not alter supine high frequency HRV in young healthy male adults. PMID:28151944

  3. Twenty-four hours, or five days, of continuous sleep deprivation or experimental sleep fragmentation do not alter thirst or motivation for water reward in rats.

    Science.gov (United States)

    Christie, Michael A; McCarley, Robert W; Strecker, Robert E

    2010-12-25

    effect on breakpoint in the progressive ratio task indicating that 5 days of SD or SF did not alter motivation for water reward. As previously reported, food consumption increased and body weight decreased during the 5 days of SD. in experiment 2. The findings indicate that although sleep disruption increases food consumption and decreases body weight, it does not alter thirst or motivation for water reward. Thus, water restriction is well suited for experiments examining the effect of sleep disruption on reward motivated behavioral tests in rats. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  4. Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas Acute effects of prolonged physical exercise: evaluation after a twenty-four-hour ultramarathon

    Directory of Open Access Journals (Sweden)

    Daniela Guinther Passaglia

    2012-01-01

    Full Text Available FUNDAMENTO: As consequências e os riscos do exercício físico contínuo por períodos prolongados não estão esclarecidos. OBJETIVO: Avaliar os efeitos do exercício prolongado em participantes de uma ultramaratona de 24 horas. MÉTODOS: Vinte corredores foram selecionados para avaliação, um dia antes e imediatamente após a prova em que os corredores devem percorrer a maior distância em 24 horas. Foram obtidos dados clínicos, laboratoriais e ecocardiográficos. RESULTADOS: A distância média percorrida foi de 140,3 ± 18,7 km. Os corredores apresentaram redução do peso corpóreo (p BACKGROUND: The consequences and risks of prolonged physical exercise are not well established. OBJECTIVE: To evaluate the effects of prolonged physical exercise on the participants of a 24-hour ultramarathon race. METHODS: Twenty male runners were selected for evaluation a day before and immediately after the race, where the athletes had to cover the most distance in 24 hours. Clinical, laboratory and echocardiographic data were obtained at both evaluations. RESULTS: Mean distance covered was 140.3 ± 18.7 km. Runners showed weight loss (p < 0.001 and decrease in systolic (p < 0.001 and diastolic (p = 0.004 blood pressure. Hematological changes were compatible with the physiological stress. Plasma levels of creatine phosphokinase strikingly increased post-race (163.4 ± 56.8 vs. 2978.4 ± 1921.9 U/L; p < 0.001 and was inversely correlated with distance covered: those who covered the longest distances showed the lowest CPK levels (Pearson r = 0.69, p = 0.02. After the race, 2 runners showed a slight increase in Troponin levels. One of them also had simultaneous decrease in left ventricular ejection fraction (coronary artery disease was subsequently ruled out. Basal echocardiography assessment had shown LV hypertrophy in one and increased left atrial volume in five runners. After the race, there was a decrease in E/A ratio (p < 0.01. CONCLUSION: Prolonged

  5. Efeitos agudos do exercício físico prolongado: avaliação após ultramaratona de 24 horas Acute effects of prolonged physical exercise: evaluation after a twenty-four-hour ultramarathon

    Directory of Open Access Journals (Sweden)

    Daniela Guinther Passaglia

    2013-01-01

    Full Text Available FUNDAMENTO: As consequências e os riscos do exercício físico contínuo por períodos prolongados não estão esclarecidos. OBJETIVO: Avaliar os efeitos do exercício prolongado em participantes de uma ultramaratona de 24 horas. MÉTODOS: Vinte corredores foram selecionados para avaliação, um dia antes e imediatamente após a prova em que os corredores devem percorrer a maior distância em 24 horas. Foram obtidos dados clínicos, laboratoriais e ecocardiográficos. RESULTADOS: A distância média percorrida foi de 140,3 ± 18,7 km. Os corredores apresentaram redução do peso corpóreo (p BACKGROUND: The consequences and risks of prolonged physical exercise are not well established. OBJECTIVE: To evaluate the effects of prolonged physical exercise on the participants of a 24-hour ultramarathon race. METHODS: Twenty male runners were selected for evaluation a day before and immediately after the race, where the athletes had to cover the most distance in 24 hours. Clinical, laboratory and echocardiographic data were obtained at both evaluations. RESULTS: Mean distance covered was 140.3 ± 18.7 km. Runners showed weight loss (p < 0.001 and decrease in systolic (p < 0.001 and diastolic (p = 0.004 blood pressure. Hematological changes were compatible with the physiological stress. Plasma levels of creatine phosphokinase strikingly increased post-race (163.4 ± 56.8 vs. 2978.4 ± 1921.9 U/L; p < 0.001 and was inversely correlated with distance covered: those who covered the longest distances showed the lowest CPK levels (Pearson r = 0.69, p = 0.02. After the race, 2 runners showed a slight increase in Troponin levels. One of them also had simultaneous decrease in left ventricular ejection fraction (coronary artery disease was subsequently ruled out. Basal echocardiography assessment had shown LV hypertrophy in one and increased left atrial volume in five runners. After the race, there was a decrease in E/A ratio (p < 0.01. CONCLUSION: Prolonged

  6. Monitorização eletrocardiográfica ambulatorial por 24-horas em cães com cardiomiopatia dilatada idiopática Twenty-four-hour ambulatory electrocardiographic monitoring in dogs with idiopathic dilated cardiomyopathy

    Directory of Open Access Journals (Sweden)

    F.L. Yamaki

    2007-12-01

    Full Text Available Caracterizou-se monitorização eletrocardiográfica ambulatorial por 24 horas (ou monitorização Holter em cães com cardiomiopatia dilatada idiopática, visando principalmente à detecção de arritmias ventriculares não detectadas pela eletrocardiografia convencional (de repouso. Para tanto, avaliaram-se 40 pacientes com diagnóstico de cardiomiopatia dilatada idiopática, por meio de exame físico e mensuração indireta da pressão arterial, além de exames eletrocardiográfico, ecocardiográfico, radiográfico de tórax e da monitorização Holter. Extra-sístoles ventriculares foram detectadas, por monitorização Holter, em 97,5% dos animais e taquicardia ventricular, em 45%. Não houve correlação entre o número de extra-sístoles ventriculares e a fração de encurtamento. Considerando as manifestações clínicas, apenas houve associação entre presença de taquicardia ventricular e histórico de síncopes. Conclui-se que a incidência de arritmias ventriculares em cães com cardiomiopatia dilatada idiopática é bastante alta, sendo a taquicardia ventricular relativamente freqüente, ocorrendo mais sob a forma não sustentada.This study aimed to characterize 24-hour ambulatory electrocardiographic monitoring (Holter monitoring in dogs with idiopathic dilated cardiomyopathy. Physical examination and indirect (Doppler blood pressure measurement, and also electrocardiography, thoracic radiography, echocardiography, and 24-hour ambulatory electrocardiographic exams were performed in 40 dogs with idiopathic dilated cardiomyopathy. Ventricular extrasystoles were detected in 97.5% of the animals, and ventricular tachycardia in 45%. No correlation between the number of ventricular extrasystoles and the shortening fraction was observed. Concerning the clinical symptoms, there was only association between the presence of ventricular tachycardia and past report of syncope. It was concluded that the incidence of ventricular arrhythmias is

  7. Twenty four Hours Circadian Cortisol Profile in Shift Work Nurses

    Directory of Open Access Journals (Sweden)

    H Kakooei

    2009-04-01

    Full Text Available ABSTRACT: Introduction & Objective: It is well established that adrenal hormone cortisol has long been used in human psychobiological studies as a biological marker of circadian rhythm, stress, and anxiety. There is little information, however, about the interrelationships of night work, plasma cortisol levels in females’ nurses of the developing countries. The aim of the present study was to compare circadian cortisol profile between two groups of nurses with shift and permanent work in a Hospital affiliated to Shiraz University of Medical Sciences, Iran, between January 2006 to September 2008. Materials & Methods: In this experimental study, we examined the reproducibility of plasma cortisol levels during one month period in 34 shift work nurses and 10 permanent day shift works. We evaluated potential associations between night work and hormone levels, using current and shift work information for the health care shift workers. Results: The results clearly revealed that shift work significantly increased nighttime cortisol levels (34.93 μg/dl during night shift and decreased the peak levels of cortisol in the morning (39.03 μg/dl. During the work shift the plasma cortisol presented a decreased concentration in the morning and increasing levels (44.93 μg/dl by the end of the evening. In contrast , the permanent day work nurses, who had never worked at night shifts, showed a lowest secretion of cortisol during the first half of night time sleep (10.02 μg/dl , and a peak value of the cortisol after awakening at 07:00 h ( 59.75 μg/ml. We also observed a significant association between night work and increased levels of cortisol over the remaining of the day. Conclusion: It can be concluded that nurses with night shift work have an abnormal cortisol secretion profile. Shift work nurses on rotating night shifts seem to experience changes in hormones levels that may be associated with increased of circadian disorders risk observed among night – shift workers.

  8. 24小时食管多通道腔内阻抗联合pH监测技术在早产儿中的应用%Role of the twenty-four-hour esophageal multichannel intraluminal impedance-pH monitoring in preterm infants

    Institute of Scientific and Technical Information of China (English)

    张娟; 李在玲; 葛颖; 王琨; 徐志杰; 夏至伟; 段丽萍

    2014-01-01

    Objective To evaluate the clinical application of 24-hour esophageal muhichannel intraluminal impedance-pH monitoring technique in preterm infants.Method This study enrolled 28 preterm(male 20,female 8)infants with symptoms suggestive of gastroesophageal reflux (GER) (frequent regurgitations,apnea,or transcutaneous oxygen saturation decreased).They had postmenstrual age from 26 to 32 weeks,median (28.9 ± 1.9) weeks,had birth weight from 850 to 1 700 g,median (1 250.4 ±272.8)g,range 850-1700 g,and were studied at corrected gestational age from 28 to 40 weeks,median (34.5 ± 2.3) weeks.Combined measurement of esophageal pH and impedance was performed.The 24-hour pH-impedance recording was uploaded onto a portable storage card and for computer-assisted manual analysis,using a specialized software program.When values were distributed normally,they were presented as mean and standard deviation,compared using t test.When values were not distributed normally,they were presented as median,minimum and maximum.Median values were compared using the Mann-Whitney U non-parametric test.SPSS 17.0 software was used.Result In 28 preterm infants,71.4% (20/28) had pathological acid refluxes with pH monitor,while 100% with combined measurement of esophageal pH and impedance.Gestational age,birth weight,corrected gestational age had no association with acid GER.Frequent regurgitations,apnea,or transcutaneous oxygen saturation decreased but there was no statistically significant difference between acid GER group and non-acid GER group.Eight cases had no pathological acid refluxes,but showed an increase of weakly acid refluxes than pathological acid refluxes group (P <0.01).The median number of reflux events in 24 hours for 28 cases was 64.5 (0-377),23.4% were acidic,while 76.4% were weakly acidic; 59.1% were liquid bolus refluxes,while 40.9% were mixed bolus refluxes.The positive ratio of symptoms related index and symptoms association probability were significantly

  9. Twenty-Four-Hour Urine Osmolality as a Physiological Index of Adequate Water Intake

    Directory of Open Access Journals (Sweden)

    Erica T. Perrier

    2015-01-01

    Full Text Available While associations exist between water, hydration, and disease risk, research quantifying the dose-response effect of water on health is limited. Thus, the water intake necessary to maintain optimal hydration from a physiological and health standpoint remains unclear. The aim of this analysis was to derive a 24 h urine osmolality (UOsm threshold that would provide an index of “optimal hydration,” sufficient to compensate water losses and also be biologically significant relative to the risk of disease. Ninety-five adults (31.5 ± 4.3 years, 23.2 ± 2.7 kg·m−2 collected 24 h urine, provided morning blood samples, and completed food and fluid intake diaries over 3 consecutive weekdays. A UOsm threshold was derived using 3 approaches, taking into account European dietary reference values for water; total fluid intake, and urine volumes associated with reduced risk for lithiasis and chronic kidney disease and plasma vasopressin concentration. The aggregate of these approaches suggest that a 24 h urine osmolality ≤500 mOsm·kg−1 may be a simple indicator of optimal hydration, representing a total daily fluid intake adequate to compensate for daily losses, ensure urinary output sufficient to reduce the risk of urolithiasis and renal function decline, and avoid elevated plasma vasopressin concentrations mediating the increased antidiuretic effort.

  10. Twenty-four hour urinary urea excretion and 9-year risk of hypertension: The PREVEND study

    NARCIS (Netherlands)

    Tielemans, S.M.A.J.; Geleijnse, J.M.; Baak, M.A. van; Engberink, M.F.; Brink, E.J.; Jong, P.E. de; Gansevoort, R.T.; Bakker, S.J.L.

    2013-01-01

    OBJECTIVES: It is not yet clear whether dietary protein could help maintaining a healthy blood pressure (BP). We investigated the association between total protein intake, estimated from 24-h urinary urea excretion, and incident hypertension in Dutch men and women. METHODS: We analyzed data of 3997

  11. Twenty-four hour radioactive iodine uptake in 35 patients with amiodarone associated thyrotoxicosis

    Energy Technology Data Exchange (ETDEWEB)

    Martino, E.; Aghini-Lombardi, F.; Lippi, F.; Baschieri, L.; Safran, M.; Braverman, L.E.; Pinchera, A.

    1985-12-01

    Amiodarone associated thyrotoxicosis (AAT) occurs in approximately 10% of patients treated with this iodine rich drug in areas of mild iodine deficiency. The thyroid radioactive iodine uptake (RAIU) is usually undetectable or very low in iodine-induced thyrotoxicosis. In the present study, 35 patients with AAT were evaluated. Twelve patients had no thyroid abnormalities by physical exam and all had 24-hr RAIU less than or equal to 4%. In contrast, nine of 11 patients with AAT and diffuse goiters and eight of 12 patients with AAT and nodular goiters had RAIU values greater than 8%. In patients with AAT and goiter it appears possible that the thyroid fails to adapt normally to the excess iodide load, resulting in an inappropriately high RAIU in the presence of excess plasma iodine.

  12. Twenty-four hour urinary urea excretion and 9-year risk of hypertension : the PREVEND study

    NARCIS (Netherlands)

    Tielemans, Susanne M. A. J.; Geleijnse, Johanna M.; van Baak, Marleen A.; Engberink, Marielle F.; Brink, Elizabeth J.; de Jong, Paul E.; Gansevoort, Ronald T.; Bakker, Stephan J. L.

    2013-01-01

    Objectives:It is not yet clear whether dietary protein could help maintaining a healthy blood pressure (BP). We investigated the association between total protein intake, estimated from 24-h urinary urea excretion, and incident hypertension in Dutch men and women.Methods:We analyzed data of 3997 men

  13. Twenty-four hour urinary urea excretion and 9-year risk of hypertension: the PREVEND study

    NARCIS (Netherlands)

    Tielemans, S.M.A.J.; Geleijnse, J.M.; Baak, van M.A.; Engberink, M.F.; Brink, E.J.; Jong, P.E.; Gansevoort, R.T.; Bakker, S.J.A.

    2013-01-01

    OBJECTIVES:: It is not yet clear whether dietary protein could help maintaining a healthy blood pressure (BP). We investigated the association between total protein intake, estimated from 24-h urinary urea excretion, and incident hypertension in Dutch men and women. METHODS:: We analyzed data of 399

  14. Effects of brewing conditions on the antioxidant capacity of twenty-four commercial green tea varieties.

    Science.gov (United States)

    Sharpe, Erica; Hua, Fang; Schuckers, Stephanie; Andreescu, Silvana; Bradley, Ryan

    2016-02-01

    A novel paper-based Nanoceria Reducing Antioxidant Capacity (NanoCerac) assay for antioxidant detection (Sharpe, Frasco, Andreescu, & Andreescu, 2012), has been adapted for the first time as a high-throughput method, in order to measure the effect of brewing conditions and re-infusion on the antioxidant capacity of twenty-four commercial green teas. The oxygen radical absorbance capacity (ORAC) assay, frequently applied to complex foods and beverages, was used as a comparator measure of antioxidant capacity. A novel measure of sustained antioxidant capacity, the total inherent antioxidant capacity (TI-NanoCerac and TI-ORAC) was measured by infusing each tea six times. Effects of brewing conditions (temperature, brew time, etc.) were assessed using one popular tea as a standard. Both NanoCerac and ORAC assays correlated moderately (R(2) 0.80 ± 0.19). The average first-brew NanoCerac, TI-NanoCerac, first-brew ORAC and TI-ORAC were: 0.73 ± 0.1 GAE/g tea; 2.4 ± 0.70 mmolGAE/g tea; 1.0 ± 0.3 mmolTE/g tea and 2.1 ± 0.71 mmolTE/g tea respectively. Brewing conditions including water temperature and infusion time significantly affected antioxidant capacity. The high-throughput adaptation of the original NanoCerac assay tested here offered advantages over ORAC, including portability and rapid analysis.

  15. Ethylene Oxide: Acute Four-Hour and One-Hour Inhalation Toxicity Testing in Rats

    Directory of Open Access Journals (Sweden)

    William M. Snellings

    2011-01-01

    Full Text Available Ethylene oxide was tested on groups of rats for either 4-hour or 1-hour inhalation exposure, followed by 14 days of observation. Groups of five Sprague-Dawley rats/sex were exposed, and clinical signs and mortality were recorded. Clinical signs noted included irregular breathing, absence of certain reflexes, and tremors. Rats that died had moderate to severe pulmonary congestion. The calculated LC50 values, reported as ppm by volume (with 95% confidence limits, were as follows. 4-hour LC50 values were 1972 (1887 to 2061 ppm for males; 1537 (1391 to 1698 ppm for females; 1741 (1655 to 1831 ppm for the combined sexes. The 1-hour LC50 values were 5748 (5276 to 6262 ppm for males; 4439 (4034 to 4884 ppm for females; 5029 (4634 to 5459 ppm for the combined sexes.

  16. Results of a 1462 hour ammonia arcjet endurance test

    Science.gov (United States)

    Polk, J. E.; Goodfellow, K. D.

    1992-07-01

    A total of 1462 hours of operaton were demonstrated in an endurance test of a 30 kWe-class ammonia arcjet operated at 10 kWe. The propellant flow rate was 0.170 g/s, and the measured performance increased from approximately 650 s specific impulse at 36 percent efficiency at the beginning of the test to 675 s at 39 percent near the end. The voltage increased and the current dropped slightly over the first 400 hours, and then remained approximately constant for the remainder of the test. The test, scheduled for 1500 hours, was terminated after an insulator in the rear of the engine failed. Post-test examination of the electrodes revealed only minimal damage. Although there was evidence of a number of mass transport processes occurring in the discharge chamber, the primary life-limiting wear mechanisms appear to be cathode tip erosion and constrictor melting.

  17. Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions.

    Science.gov (United States)

    Smolensky, Michael H; Portaluppi, Francesco; Manfredini, Roberto; Hermida, Ramon C; Tiseo, Ruana; Sackett-Lundeen, Linda L; Haus, Erhard L

    2015-06-01

    The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, Parkinson's and Alzheimer's disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot ulcer, tooth caries, burning mouth and temporomandibular syndromes, fibromyalgia, sciatica, intervertebral vacuum phenomenon, multiple sclerosis muscle spasm, and migraine, tension, cluster, hypnic, and paroxysmal hemicranial headache); renal: colic and nocturnal enuresis and polyuria; ocular: bulbar conjunctival redness, keratoconjunctivitis sicca, intraocular pressure and anterior ischemic optic neuropathy, and recurrent corneal erosion syndrome; psychiatric/behavioral: major and seasonal affective depressive disorders, bipolar disorder, parasuicide and suicide, dementia-associated agitation, and addictive alcohol, tobacco, and heroin cravings and withdrawal phenomena; plus autoimmune and musculoskeletal: rheumatoid arthritis, osteoarthritis, axial spondylarthritis, gout, Sjögren's syndrome, and systemic lupus erythematosus. Knowledge of these and other 24 h patterns of human pathophysiology informs research of their underlying circadian and other endogenous mechanisms, external temporal triggers, and more effective patient care entailing clinical chronopreventive and chronotherapeutic strategies.

  18. Twenty-four hour predictions of the solar wind speed peaks by the probability distribution function model

    Science.gov (United States)

    Bussy-Virat, C. D.; Ridley, A. J.

    2016-10-01

    Abrupt transitions from slow to fast solar wind represent a concern for the space weather forecasting community. They may cause geomagnetic storms that can eventually affect systems in orbit and on the ground. Therefore, the probability distribution function (PDF) model was improved to predict enhancements in the solar wind speed. New probability distribution functions allow for the prediction of the peak amplitude and the time to the peak while providing an interval of uncertainty on the prediction. It was found that 60% of the positive predictions were correct, while 91% of the negative predictions were correct, and 20% to 33% of the peaks in the speed were found by the model. This represents a considerable improvement upon the first version of the PDF model. A direct comparison with the Wang-Sheeley-Arge model shows that the PDF model is quite similar, except that it leads to fewer false positive predictions and misses fewer events, especially when the peak reaches very high speeds.

  19. Diurnal and twenty-four hour patterning of human diseases: cardiac, vascular, and respiratory diseases, conditions, and syndromes.

    Science.gov (United States)

    Smolensky, Michael H; Portaluppi, Francesco; Manfredini, Roberto; Hermida, Ramon C; Tiseo, Ruana; Sackett-Lundeen, Linda L; Haus, Erhard L

    2015-06-01

    Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24 h patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ones of atrial premature beats and tachycardia, paroxysmal atrial fibrillation, 3rd degree atrial-ventricular block, paroxysmal supraventricular tachycardia, ventricular premature beats, ventricular tachyarrhythmia, symptomatic and non-symptomatic angina pectoris, Prinzmetal vasospastic variant angina, acute (non-fatal and fatal) incidents of myocardial infarction, sudden cardiac arrest, in-bed sudden death syndrome of type-1 diabetes, acute cardiogenic pulmonary edema, and heart failure; vascular and circulatory system ones of hypertension, acute orthostatic postprandial, micturition, and defecation hypotension/syncope, intermittent claudication, venous insufficiency, standing occupation leg edema, arterial and venous branch occlusion of the eye, menopausal hot flash, sickle cell syndrome, abdominal, aortic, and thoracic dissections, pulmonary thromboembolism, and deep venous thrombosis, and cerebrovascular transient ischemic attack and hemorrhagic and ischemic stroke. Knowledge of these temporal patterns not only helps guide patient care but research of their underlying endogenous mechanisms, i.e., circadian and others, and external triggers plus informs the development and application of effective chronopreventive and chronotherapeutic strategies.

  20. Twenty-four-hour urine constituents in stone formers: A study from the northeast part of Peninsular Malaysia

    OpenAIRE

    N S Hussein; S M Sadiq; M D Kamaliah; A W NorAkmal; M N Gohar

    2013-01-01

    Urolithiasis is a common disease with increasing incidence and prevalence world-wide, probably more common in industrialized countries. The metabolic evaluation of 24-h urine collection has been considered as part of the management of urinary stone patients. The aim of this study was to evaluate the 24-h urine constituents in stone formers and its relation to demographic data in the northeast part of Peninsular Malaysia. One hundred and six patients were recruited in this study from two hospi...

  1. Twenty-four hours or 10 days? A prospective randomised controlled trial in children comparing head bandages following pinnaplasty.

    Science.gov (United States)

    Ramkumar, S; Narayanan, V; Laing, J H E

    2006-01-01

    The perceived benefits of bandaging for 10 days following pinnaplasty have been questioned by previous studies. The problems arising from these dressings are many [Powell BWEM. The value of head dressings in the postoperative management of the prominent ear. Br J Plast Surg 1989;42:692-4. Bartley J. How long should ears be bandaged after otoplasty? J Laryngol Otol 1998;112:531-2. Wong MC, Sylaidis P. Head dressings for pinnaplasty: a tradition not supported by evidence. Br J Plast Surg 2001;54:81-2], including their slippage [Powell BWEM. The value of head dressings in the postoperative management of the prominent ear. Br J Plast Surg 1989;42:692-4. Bradbury ET, Hewison J, Timmons MJ. Psychological and social outcome of prominent ear correction in children. Br J Plast Surg 1992;45:97-100. Jeffery SLA. Complications following correction of prominent ears: an audit review of 122 cases. Br J Plast Surg 1999;52:588-90]. Eighty children were recruited into a prospective randomised controlled trial comparing the use of a head bandage for only 24 h with a standard practise of a 10-day head bandage. A preoperative measurement of the lateral ear projection (LEP) was made. The outcome measures recorded during the two planned postoperative visits at 10 days (visit 1) and 2 months (visit 2) were: patient satisfaction score, LEP, complications and any unscheduled hospital visits associated with the surgery. There was no significant difference in LEP and patient satisfaction between the two groups at both the scheduled postoperative visits. Differences between the groups in the number of unscheduled visits (p=0.21) did not reach statistical significance. The findings indicate that it is safe and effective to use head bandage for only 24 h following surgical correction of prominent ears. This study shows no benefit from the application of a formal head bandage for any longer than 1 day.

  2. Twenty-four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats

    DEFF Research Database (Denmark)

    Sandu, Raluca Elena; Buga, Ana Maria; Balseanu, Adrian Tudor

    2016-01-01

    inflammation and infarct size. However, after 1 week, the infarct size became even larger than in controls and after 2 weeks there was no beneficial effect on regenerative processes such as neurogenesis. Behaviorally, hypothermia also had a limited beneficial effect. Finally, after hydrogen sulfide...

  3. Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries

    DEFF Research Database (Denmark)

    Hilgers, Rob H P; Janssen, Ger M J; Fazzi, Gregorio E

    2010-01-01

    ,5,12,16]tetraazacyclotricosine-5,13-diium dibromide (UCL 1684; inhibitor of SK3) or 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34; inhibitor of IK1). In LF arteries, endothelium-dependent relaxation was markedly reduced, due to a reduction in the endothelium-derived hyperpolarizing factor (EDHF) response. In HF...

  4. Production Facility Prototype Blower 1000 Hour Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Frank Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-18

    The roots blower in use at ANL for in-beam experiments and also at LANL for flow tests was sized for 12 mm diameter disks and significantly less beam heating. Currently, the disks are 29 mm in diameter, with a 12 mm FWHM Gaussian beam spot at 42 MeV and 2.86 μA on each side of the target, 5.72 μA total. The target design itself is reported elsewhere. With the increased beam heating, the helium flow requirement increased so that a larger blower was need for a mass flow rate of 400 g/s at 2.76 MPa (400 psig). An Aerzen GM 12.4 blower was selected, and is now installed at the LANL facility for target and component flow testing. Two extended test of >1000 hr operation have been completed. Those results and discussion thereof are reported herein. Also included in Appendix A is the detailed description of the blower and its installation, while Appendix B documents the pressure vessel design analysis. The blower has been operated for 1000 hours as a preliminary investigation of long term performance, operation and possible maintenance issues. The blower performed well, with no significant change in blower head or mass flow rate developed under the operating conditions. Upon inspection, some oil had leaked out of the shaft seal of the blower. The shaft seal and bearing race have been replaced. Test results and conclusions are in Appendix B.

  5. Production Facility Prototype Blower 1000 Hour Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Frank Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-18

    The roots blower in use at ANL for in-beam experiments and also at LANL for flow tests was sized for 12 mm diameter disks and significantly less beam heating. Currently, the disks are 29 mm in diameter, with a 12 mm FWHM Gaussian beam spot at 42 MeV and 2.86 μA on each side of the target, 5.72 μA total. The target design itself is reported elsewhere. With the increased beam heating, the helium flow requirement increased so that a larger blower was needed for a mass flow rate of 400 g/s at 2.76 MPa (400 psig). An Aerzen GM 12.4 blower was selected, and is now installed at the LANL facility for target and component flow testing. Two extended tests of >1000 hr operation have been completed. Those results and discussion thereof are reported herein. Also included in Appendix A is the detailed description of the blower and its installation, while Appendix B documents the pressure vessel design analysis. The blower has been operated for 1000 hours as a preliminary investigation of long-term performance, operation and possible maintenance issues. The blower performed well, with no significant change in blower head or mass flow rate developed under the operating conditions. Upon inspection, some oil had leaked out of the shaft seal of the blower. The shaft seal and bearing race have been replaced. Test results and conclusions are in Appendix B.

  6. Malignant peripheral nerve sheath tumors (MPNST – Clinicopathological study and treatment outcome of twenty-four cases

    Directory of Open Access Journals (Sweden)

    DattaGupta Sidharth

    2006-08-01

    Full Text Available Abstract Background Malignant peripheral nerve sheath tumor (MPNST is biologically an aggressive tumor for which the treatment of choice is the surgery. We reviewed the clinical profile, diagnostic methods, treatment patterns, and outcome of twenty-four MPNST patients in this study. Patients and methods A retrospective analysis of 24 MPNST patients, treated from 1994 to 2002, in the department of Surgical Oncology at All India Institute of Medical Sciences, New Delhi, was done. A combination of gross, histopathological and immunohistochemical findings, and proliferation markers (MIB1 were considered for diagnosis and grade of the MPNST. Survival analysis was done by the Kaplan-Meier method and differences were evaluated with the log-rank test. Multivariate analysis was carried out by using Cox's proportional hazards model by using SPSS (Version 9, Chicago, Illinois software. Results MPNST constituted 12% of all soft tissue sarcomas, where 21% (5/24 of patients had associated Von Recklinghausen's disease (VRHD. A higher incidence of male preponderance and multifocal MPNST were noted in the present series. At a mean follow-up of 38 months, 13 (54 % patients had relapse of disease and 5-year over all and disease free survival were 58% and 35% respectively. In univariate analysis, sex (p = 0.05, tumor depth (p p p = 0.04, cellular differentiation (p p = 0.05 for overall survival. However, in multivariate analysis, cellular differentiation (p p Conclusion MPNSTs constituted a significant proportion (12% of soft tissue sarcoma in our medical center. Heterogeneous differentiation and multifocality of the tumor were few distinct features of MPNST. Sex and cellular differentiation were noticed as the new adverse prognostic factors and adjuvant radiotherapy has been proved to be a significant treatment tool in the current series.

  7. 7 CFR 91.37 - Standard hourly fee rate for laboratory testing, analysis, and other services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Standard hourly fee rate for laboratory testing... Charges § 91.37 Standard hourly fee rate for laboratory testing, analysis, and other services. (a) The standard hourly fee rate in this section for the individual laboratory analyses cover the costs of...

  8. Biomimetic Synthesis of Twenty-four Long-chained Diketones as Precursors for Muscone and Further Macrocyclic Ketones

    Institute of Scientific and Technical Information of China (English)

    GUO,Yuan; CHEN,Kang-yu; LI,Jian-Li; SHI,Zhen

    2008-01-01

    The one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. Bisbenzimidazolium salts were used as a tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of twenty-four acyclic dike-tones as precursors for macrocyclic ketones was successfully accomplished by using the addition-hydrolysis reac-tion of the bisbenzimidazolium salts with alkyl magnesium halide, wherein six diketones have not been reported in literature. Accordingly, a short route to muscone analogues was provided.

  9. Twenty four year time trends in fats and cholesterol intake by adolescents. Warsaw Adolescents Study

    Directory of Open Access Journals (Sweden)

    Charzewska Jadwiga

    2015-06-01

    Full Text Available The objective of this study was to determine time trends (1982–2006 in total fat intake and changes in fatty acid structure intake in adolescents from Warsaw in view of increasing prevalence of obesity. Data come from four successive surveys randomly selected samples of adolescents (aged 11–15 years old, from Warsaw region. In total 9747 pupils have been examined, with response rate varying from 55% to 87% depending on year. Surveys were done always in the spring season of the year. Food intake was assessed by using 24 hours recall method of consumption by the pupils all products, including enriched, dishes and beverages as well as diet supplements, in the last 24 hours preceding the examination. The content of energy and nutrients was calculated by means of own computer softwares (DIET 2 and 4, taking into account successive revisions of the tables of food composition and nutritional values, as well as current Polish DRI. A significant decreasing trend was found in intake of total fat, of saturated fatty acids (SFA and cholesterol. The percentage of energy from total fat, also decreased both in boys (to 35,1% and girls (to 33,7%, what failed to reach the desired level below 30% of energy from fat which is recommended. Also significant decrease of SFA consumption was not satisfactory enough to approach the values <10% of energy recommended as was from 13% to 15%. Decreasing trends in fat intake was not in accordance with the trend in obesity prevalence in the adolescents as average BMI is going up. To stabilize the health-oriented changes especially in the diets of adolescents, further activity is desired from professionals working with prevention of adolescents obesity.

  10. Tetrahydrobiopterin responsiveness in phenylketonuria : prediction with the 48-hour loading test and genotype

    NARCIS (Netherlands)

    Anjema, Karen; van Rijn, Margreet; Hofstede, Floris C; Bosch, Annet M; Hollak, Carla E M; Rubio-Gozalbo, Estela; de Vries, Maaike C; Janssen, Mirian C H; Boelen, Carolien C A; Burgerhof, Johannes G M; Blau, Nenad; Fokkema, Margaretha; van Spronsen, Francjan J

    2013-01-01

    Background: How to efficiently diagnose tetrahydrobiopterin (BH4) responsiveness in patients with phenylketonuria remains unclear. This study investigated the positive predictive value (PPV) of the 48-hour BH4 loading test and the additional value of genotype. Methods: Data of the 48-hour BH4 loadin

  11. Direct Susceptibility testing of Urine samples after 6, 9 and 16 hours incubation

    DEFF Research Database (Denmark)

    Ghatian, Khaled; Littauer, Pia; Llado, Minna Fyhn Lykke

    2015-01-01

    Objectives: At present, susceptibility testing of infective bacteria from urine samples, according to EUCAST, is interpretation of zones after 16 hours of incubation. Using a semi-automated sample processing, the Kiestra (BD) system, to incubate of the agar plates and digital image processing...... testing on urine samples. Methods: In total 675 consecutive urine samples from out-patients, were inoculated directly, according to our laboratory standard, as 10µL on each part of a bi-plate (oxoid chomogene agar and 5% horse blood-agar) and 10µL on a MH plate for resistance testing, using an Inoqula...... (Kiestra-BD). The plates were photographed at 6, 9 and 16 hours after incubation. As a gold standard, the susceptibility test was performed according to EUCAST, as a secondary susceptibility testing, for colonies identified on the biplates, and read after 16 hours incubation.The disks used (Oxoid, Termo...

  12. Twenty-Four-Hour Real-Time Continuous Monitoring of Cerebral Edema in Rabbits Based on a Noninvasive and Noncontact System of Magnetic Induction

    Directory of Open Access Journals (Sweden)

    Gen Li

    2017-03-01

    Full Text Available Cerebral edema is a common disease, secondary to craniocerebral injury, and real-time continuous monitoring of cerebral edema is crucial for treating patients after traumatic brain injury. This work established a noninvasive and noncontact system by monitoring the magnetic induction phase shift (MIPS which is associated with brain tissue conductivity. Sixteen rabbits (experimental group n = 10, control group, n = 6 were used to perform a 24 h MIPS and intracranial pressure (ICP simultaneously monitored experimental study. For the experimental group, after the establishment of epidural freeze-induced cerebral edema models, the MIPS presented a downward trend within 24 h, with a change magnitude of −13.1121 ± 2.3953°; the ICP presented an upward trend within 24 h, with a change magnitude of 12–41 mmHg. The ICP was negatively correlated with the MIPS. In the control group, the MIPS change amplitude was −0.87795 ± 1.5146 without obvious changes; the ICP fluctuated only slightly at the initial value of 12 mmHg. MIPS had a more sensitive performance than ICP in the early stage of cerebral edema. These results showed that this system is basically capable of monitoring gradual increases in the cerebral edema solution volume. To some extent, the MIPS has the potential to reflect the ICP changes.

  13. Twenty-Four Hour Total and Dietary Fat Oxidation in Lean, Obese and Reduced-Obese Adults with and without a Bout of Exercise

    Science.gov (United States)

    Bergouignan, Audrey; Kealey, Elizabeth H.; Schmidt, Stacy L.; Jackman, Matthew R.; Bessesen, Daniel H.

    2014-01-01

    Background It has been hypothesized that obese and reduced-obese individuals have decreased oxidative capacity, which contributes to weight gain and regain. Recent data have challenged this concept. Objective To determine (1) whether total and dietary fat oxidation are decreased in obese and reduced-obese adults compared to lean but increase in response to an acute exercise bout and (2) whether regular physical activity attenuates these metabolic alterations. Design We measured 24-hr total (whole-room calorimetry) and dietary fat (14C-oleate) oxidation in Sedentary Lean (BMI = 21.5±1.6; n = 10), Sedentary Obese (BMI = 33.6±2.5; n = 9), Sedentary Reduced-Obese (RED-SED; BMI = 26.9±3.7; n = 7) and in Physically Active Reduced-Obese (RED-EX; BMI = 27.3±2.8; n = 12) men and women with or without an acute exercise bout where energy expended during exercise was not replaced. Results Although Red-SED and Red-EX had a similar level of fatness, aerobic capacity and metabolic profiles were better in Red-EX only compared to Obese subjects. No significant between-group differences were seen in 24-hr respiratory quotient (RQ, Lean: 0.831±0.044, Obese: 0.852±0.023, Red-SED: 0.864±0.037, Red-EX: 0.842±0.039), total and dietary fat oxidation. A single bout of exercise increased total (+27.8%, p<0.0001) and dietary (+6.6%, p = 0.048) fat oxidation across groups. Although exercise did not impact RQ during the day, it decreased RQ during sleep (p = 0.01) in all groups. Red-EX oxidized more fat overnight than Red-SED subjects under both resting (p = 0.036) and negative energy balance (p = 0.003) conditions, even after adjustment for fat-free mass. Conclusion Obese and reduced-obese individuals oxidize as much fat as lean both under eucaloric and negative energy balance conditions, which does not support the hypothesis of reduced oxidative capacity in these groups. Reduced-obese individuals who exercise regularly have markers of metabolic health similar to those seen in lean adults. Both the acute and chronic effects of exercise were primarily observed at night suggesting an important role of sleep in the regulation of lipid metabolism. PMID:24714529

  14. Twenty-four hour total and dietary fat oxidation in lean, obese and reduced-obese adults with and without a bout of exercise.

    Directory of Open Access Journals (Sweden)

    Audrey Bergouignan

    Full Text Available It has been hypothesized that obese and reduced-obese individuals have decreased oxidative capacity, which contributes to weight gain and regain. Recent data have challenged this concept.To determine (1 whether total and dietary fat oxidation are decreased in obese and reduced-obese adults compared to lean but increase in response to an acute exercise bout and (2 whether regular physical activity attenuates these metabolic alterations.We measured 24-hr total (whole-room calorimetry and dietary fat (14C-oleate oxidation in Sedentary Lean (BMI = 21.5±1.6; n = 10, Sedentary Obese (BMI = 33.6±2.5; n = 9, Sedentary Reduced-Obese (RED-SED; BMI = 26.9±3.7; n = 7 and in Physically Active Reduced-Obese (RED-EX; BMI = 27.3±2.8; n = 12 men and women with or without an acute exercise bout where energy expended during exercise was not replaced.Although Red-SED and Red-EX had a similar level of fatness, aerobic capacity and metabolic profiles were better in Red-EX only compared to Obese subjects. No significant between-group differences were seen in 24-hr respiratory quotient (RQ, Lean: 0.831±0.044, Obese: 0.852±0.023, Red-SED: 0.864±0.037, Red-EX: 0.842±0.039, total and dietary fat oxidation. A single bout of exercise increased total (+27.8%, p<0.0001 and dietary (+6.6%, p = 0.048 fat oxidation across groups. Although exercise did not impact RQ during the day, it decreased RQ during sleep (p = 0.01 in all groups. Red-EX oxidized more fat overnight than Red-SED subjects under both resting (p = 0.036 and negative energy balance (p = 0.003 conditions, even after adjustment for fat-free mass.Obese and reduced-obese individuals oxidize as much fat as lean both under eucaloric and negative energy balance conditions, which does not support the hypothesis of reduced oxidative capacity in these groups. Reduced-obese individuals who exercise regularly have markers of metabolic health similar to those seen in lean adults. Both the acute and chronic effects of exercise were primarily observed at night suggesting an important role of sleep in the regulation of lipid metabolism.

  15. Twenty-four-hour simultaneous subcutaneous basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia

    Science.gov (United States)

    The purpose of this study was to examine the effect of continuous subcutaneous (sc) replacement of amylin and insulin for a 24-h period on glucose homeostasis in adolescents with type 1 diabetes. Thirteen adolescents with type 1 diabetes on insulin pump therapy participated in a randomized, controll...

  16. Twenty-four-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver; possible physiological significance in phospholipid methylation.

    Science.gov (United States)

    Chagoya de Sánchez, V; Hernández-Muñoz, R; Sánchez, L; Vidrio, S; Yáñez, L; Suárez, J

    1991-01-01

    1. The metabolic control of adenosine concentration in the rat liver through the 24-hr cycle is related to the activity of adenosine-metabolizing enzymes [5'-nucleotidase (5'N), adenosine deaminase (A.D.), adenosine kinase (A.K.) and S-adenosylhomocysteine hydrolase (SAH-H)]. 2. Two peaks of adenosine were observed, one at 12:00 hr caused by high activity of 5'N and SAH-H, and the other at 02:00 hr, caused by a decrease in purine catabolism and purine utilization, low activity of SAH-H and de novo purine formation. 3. The similarity of the adenosine and S-adenosylmethionine (SAM) profiles through the 24-hr cycle suggests a role of adenosine in transmethylation reactions, because, during the night (02:00 hr), the metabolic conditions favor the formation and accumulation of S-adenosylhomocysteine (SAH), with consequent inhibition of transmethylation reactions. 4. In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima.

  17. Twenty-four-hour central blood pressure is not better associated with hypertensive target organ damage than 24-h peripheral blood pressure.

    Science.gov (United States)

    de la Sierra, Alejandro; Pareja, Julia; Fernández-Llama, Patricia; Armario, Pedro; Yun, Sergi; Acosta, Eva; Calero, Francesca; Vázquez, Susana; Blanch, Pedro; Sierra, Cristina; Oliveras, Anna

    2017-10-01

    Central blood pressure (BP) is increasingly considered as a better estimator of hypertension associated risks. We aimed to evaluate the association of 24-h central BP, in comparison with 24-h peripheral BP, with the presence of target organ damage (TOD). Cross-sectional study of 208 hypertensive patients, aged 57 ± 12 years, 34% women. Office (mean of 4 measurements) and 24-h central and peripheral BP were measured by the oscillometric Mobil-O-Graph device. TOD was assessed at cardiac (left ventricular hypertrophy by echocardiography), renal (reduction of glomerular filtration rate and/or microalbuminuria), and arterial (increased aortic pulse wave velocity) levels. A total of 107 patients (51.4%) had TOD (77, 35% patients left ventricular hypertrophy; 54, 25.9% renal abnormalities; and 40, 19.2% arterial stiffness). All SBP and pulse BP estimates (office, 24-h, daytime, and night-time) were associated with the presence of TOD, after adjustment for age, sex, and antihypertensive treatment, with higher odds ratios for ambulatory-derived values. Odds ratios for central and peripheral BP were similar for all office, 24-h, daytime, and night-time BP. After simultaneous adjustment, peripheral, but not central, 24-h and night-time SBP and pulse pressures were associated with the presence of TOD. TOD in hypertension is associated with BP elevation, independently of the type of measurement (office or ambulatory, central or peripheral). Central BP, even monitored during 24 h, is not better associated with TOD than peripheral BP. These results do not support a routine measurement of 24-h central BP.

  18. Twenty four hour insulin infusion impairs the ability of plasma from healthy subjects and Type 2 diabetic patients to promote cellular cholesterol efflux

    NARCIS (Netherlands)

    Dullaart, RPF; van Tol, A

    Removal of cholesterol from peripheral cells by high density lipoproteins (HDL) is regarded as an important defence mechanism against atherosclerosis development. PLTP is involved in the generation of pre beta -HDL that can act as initial accepters of cellular cholesterol. Exogenous

  19. Twenty-four Hour Endocrine and Metabolic Profiles Following Consumption of High Fructose Corn Syrup-, Sucrose- Fructose-, and Glucose-Sweetened Beverages with Meals

    Science.gov (United States)

    We have reported that compared with glucose-sweetened beverages, consuming fructose-sweetened beverages with meals results in lower 24-h circulating glucose, insulin and leptin concentrations, and elevated triacylglycerol (TG). However, pure fructose and glucose are not commonly used as sweeteners. ...

  20. Characterization testing of a 40 ampere hour bipolar nickel-hydrogen battery

    Science.gov (United States)

    Brewer, Jeffrey C.; Manzo, Michelle A.; Gemeiner, Russel P.

    1990-01-01

    Extensive characterization testing has been done on a second 40-ampere hour (A h), 10-cell, bipolar nickel-hydrogen (Ni-H2) battery, to study the effects of operating parameters such as charge and discharge rates, temperature, and pressure on capacity, A h and watt hour (W h) efficiencies, and end-of-charge and midpoint discharge voltages. Testing to date has produced many interesting results, with the battery performing well throughout the test matrix except during the high-rate (5 C and 10 C) discharges, where poorer than expected results were observed. The exact cause of this poor performance is, as yet, unknown. Small scale 2 in. x 2 in. battery tests are to be used in studying this problem. Low earth orbit cycle life testing at a 40-percent depth of discharge and 10 C is scheduled to follow the characterization testing.

  1. Survival of the ’net’est? Experiences with electronic test tools – reduced teacher hours?

    Directory of Open Access Journals (Sweden)

    Kristin Dale

    2008-07-01

    Full Text Available More feedback to students is demanded to improve educational quality. In large courses individual feedback is often very time-demanding for the teacher. If teacher hours are only marginally increased to cover increased student feedback, teachers should look for electronic tools for assistance with student feedback that will reduce teacher work hours, at least in the long run. This paper reports my experiences with electronic multiple – choice tests in mid-term feed-back to students in large courses in undergraduate studies. It reports a lot of the decisions that the teacher has to make when creating a multiple-choice test for a course such as the choice between a paper or electronic test, number and type of questions, number of answer options, scores for right and wrong answers and manual or electronic scoring. The paper also addresses the communication with students before and after the test, the need for administrative support and finally discusses the costs and benefits with respect to teacher hours. These experiences may be useful to teachers who consider using electronic test-tools.

  2. 'Where of is mad al mankynde' : an edition of and introduction to the twenty-four poems in Oxford, Bodleian Library, MS Digby 102

    NARCIS (Netherlands)

    Verheij, Louis Johan Philip

    2009-01-01

    'Where of is Mad al Mankynde' represents a new critical edition of the collection of twenty-four late-medieval anonymous poems contained, among other pieces, in Oxford, Bodleian Library, MS Digby 102. Each poem is introduced with a brief summary and closes with line-for-line explanatory comments. Th

  3. Surgical treatment of cavus foot in Charcot-Marie-tooth disease: a review of twenty-four cases: AAOS exhibit selection.

    Science.gov (United States)

    Faldini, Cesare; Traina, Francesco; Nanni, Matteo; Mazzotti, Antonio; Calamelli, Carlotta; Fabbri, Daniele; Pungetti, Camilla; Giannini, Sandro

    2015-03-18

    Charcot-Marie-Tooth disease is the single most common diagnosis associated with cavus foot. The imbalance involving intrinsic and extrinsic muscles has been suggested as the main pathogenetic cause of cavus foot in this disease. The goal of surgical treatment is to correct the deformity to obtain a plantigrade foot. In the presence of a flexible deformity and the absence of degenerative arthritis, preserving as much as possible of the overall range of motion of the foot and ankle is advisable. Twenty-four cavus feet in twelve patients with Charcot-Marie-Tooth disease were included in the study. Clinical evaluation was summarized with the Maryland Foot Score. Radiographic evaluation assessed calcaneal pitch, Meary angle, Hibb angle, and absence of degenerative joint changes. Only patients who had a flexible deformity, with varus of the heel reducible in the Coleman-Andreasi test, and did not have degenerative joint arthritis were included in this study. Surgical treatment consisted in plantar fasciotomy, midtarsal osteotomy, extensor hallucis longus tendon transfer to the first metatarsal (Jones procedure), and dorsiflexion osteotomy of the first metatarsal. Mean follow-up was six years (range, two to thirteen years). The mean Maryland Foot Score was 72 preoperatively and 86 postoperatively. The postoperative result was rated as excellent in twelve feet (50%), good in ten (42%), and fair in two (8%). Mean calcaneal pitch was 34° preoperatively and 24° at the time of the latest follow-up, the mean Hibb angle was 121° preoperatively and 136° postoperatively, and the mean Meary angle was 25° preoperatively and 2° postoperatively. Plantar fasciotomy, midtarsal osteotomy, the Jones procedure, and dorsiflexion osteotomy of the first metatarsal yielded adequate correction of flexible cavus feet in patients with Charcot-Marie-Tooth disease in the absence of fixed hindfoot deformity. The fact that the improvement in the outcome score was only modest may be attributable

  4. A two-hour antibiotic susceptibility test by ATP-bioluminescence.

    Science.gov (United States)

    March Rosselló, Gabriel Alberto; García-Loygorri Jordán de Urries, María Cristina; Gutiérrez Rodríguez, María Purificación; Simarro Grande, María; Orduña Domingo, Antonio; Bratos Pérez, Miguel Ángel

    2016-01-01

    The antibiotic susceptibility test (AST) in Clinical Microbiology laboratories is still time-consuming, and most procedures take 24h to yield results. In this study, a rapid antimicrobial susceptibility test using ATP-bioluminescence has been developed. The design of method was performed using five ATCC collection strains of known susceptibility. This procedure was then validated against standard commercial methods on 10 strains of enterococci, 10 staphylococci, 10 non-fermenting gram negative bacilli, and 13 Enterobacteriaceae from patients. The agreement obtained in the sensitivity between the ATP-bioluminescence method and commercial methods (E-test, MicroScan and VITEK2) was 100%. In summary, the preliminary results obtained in this work show that the ATP-bioluminescence method could provide a fast and reliable AST in two hours.

  5. Analysis of Hourly Climatic Variables-Meteorological Test Reference Year for Beijing

    DEFF Research Database (Denmark)

    Qin, Lin

    1997-01-01

    The climatic data which was surveyed from 1981 to 1993 in Beijing was analysed to generate a representative year, a Test Reference Year (TRY). This TRY consists of just one year of hourly data that could yield the same simulation results as the long-term data, thereby minimizing the computation...... need to assess long-term system performance. It can be used as input data for the simulation of the performance of solar energy and indoor climate systems. The application of this TRY in the simulation of a solar domestic hot water system is also presented....

  6. Effect of a 24+ hour fast on breast milk composition.

    Science.gov (United States)

    Zimmerman, Deena R; Goldstein, Lee; Lahat, Eli; Braunstein, Rony; Stahi, Dvorah; Bar-Haim, Adina; Berkovitch, Matitiahu

    2009-05-01

    In this preliminary prospective study, breast milk is sampled surrounding 4 religious fast days to determine the effect of a more than 24-hour fast on breast milk composition. The participants are 48 healthy women nursing healthy babies between 1 and 6 months of age. Samples are collected within 2 days before the fast (baseline), immediately after the fast, and 24 hours after fast completion. Samples are tested for sodium, calcium, phosphorus, triglycerides, total protein, and lactose. From baseline to immediately after fast, mean sodium, calcium, and protein levels increase (P = .013, P < .0001, and P < .0001, respectively) and mean phosphorus and lactose levels decrease (P < .0001 and P = .003, respectively). Mean triglycerides are unchanged. Twenty-four hours after fast, parameters are no longer significantly different from baseline except for elevated mean protein levels (P = .022) and lactose that is still reduced (P = .017). A fast of this nature is statistically associated with certain biochemical changes in breast milk.

  7. The 48-hour tetrahydrobiopterin loading test in patients with phenylketonuria : Evaluation of protocol and influence of baseline phenylalanine concentration

    NARCIS (Netherlands)

    Anjema, K.; Venema, G.; Hofstede, F. C.; Weber, E. C. Carbasius; Bosch, A. M.; Ter Horst, N. M.; Hollak, C. E. M.; Jonkers, C. F.; Rubio-Gozalbo, M. E.; van der Ploeg, E. M. C.; de Vries, M. C.; Janssen-Regelink, R. G.; Janssen, M. C. H.; Essen, H. Zweers-van; Boelen, C. C. A.; van der Herberg-van de Wetering, N. A. P.; Heiner-Fokkema, Rebecca; van Rijn, M.; van Spronsen, F. J.

    2011-01-01

    BACKGROUND: The 24- and 48-hour tetrahydrobiopterin (BH4) loading test (BLT) performed at a minimum baseline phenylalanine concentration of 400 μmol/l is commonly used to test phenylketonuria patients for BH4 responsiveness. This study aimed to analyze differences between the 24- and 48-hour BLT and

  8. Production Facility Prototype Blower Installation Report with 1000 Hour Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Woloshun, Keith Albert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dale, Gregory E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Romero, Frank Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dalmas, Dale Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-04-01

    The roots blower in use at ANL for in-beam experiments and also at LANL for flow tests was sized for 12 mm diameter disks and significantly less beam heating. Currently, the disks are 29 mm in diameter, with a 12 mm FWHM Gaussian beam spot at 42 MeV and 2.86 μA on each side of the target, 5.72 μA total. The target design itself is reported elsewhere. With the increased beam heating, the helium flow requirement increased so that a larger blower was needed for a mass flow rate of 400 g/s at 2.76 MPa (400 psig). An Aerzen GM 12.4 blower was selected, and is currently being installed at the LANL facility for target and component flow testing. This report describes this blower/motor/pressure vessel package and the status of the facility preparations. The blower has been operated for 1000 hours as a preliminary investigation of long term performance, operation and possible maintenance issues. The blower performed well, with no significant change in blower head or mass flow rate developed under the operating conditions. Upon inspection, some oil had leaked out of the shaft seal of the blower. The shaft seal and bearing race have been replaced. Test results and conclusions are reported.

  9. [Results of Training for Personnel Involved in Blood-Transfusion Testing Outside of Regular Work Hours at Saga University Hospital].

    Science.gov (United States)

    Yamada, Marie; Yamada, Naotomo; Higashitani, Takanori; Ohta, Shoichiro; Sueoka, Eisaburo

    2015-11-01

    Laboratory testing prior to blood transfusion outside of regular hours in many hospitals and clinics is frequently conducted by technicians without sufficient experience in such testing work. To obtain consistent test results regardless of the degree of laboratory experience with blood transfusion testing, the number of facilities introducing automated equipment for testing prior to blood transfusion is increasing. Our hospital's blood transfusion department introduced fully automated test equipment in October of 2010 for use when blood transfusions are conducted outside of regular hours. However, excessive dependence on automated testing can lead to an inability to do manual blood typing or cross-match testing when necessitated by breakdowns in the automated test equipment, in the case of abnormal specimen reactions, or other such case. In addition, even outside of normal working hours there are more than a few instances in which transfusion must take place based on urgent communications from clinical staff, with the need for prompt and flexible timing of blood transfusion test and delivery of blood products. To address this situation, in 2010 we began training after-hours laboratory personnel in blood transfusion testing to provide practice using test tubes manually and to achieve greater understanding of blood transfusion test work (especially in cases of critical blood loss). Results of the training and difficulties in its implementation for such after-hours laboratory personnel at our hospital are presented and discussed in this paper. [Original

  10. Exploring the relationship between cyberbullying and unnatural child death: an ecological study of twenty-four European countries.

    Science.gov (United States)

    Fu, King-wa; Chan, Chung-hong; Ip, Patrick

    2014-07-30

    Internet risk has been recognised as a child safety problem, but evidence is insufficient to conclude that a child's online risk exposure can lead to physical harm. This study aims to explore the ecological relationship between Internet risk exposure and unnatural child death. Multiple secondary data sources were used: online exposure to content about self-harm, cyberbullying, and Internet addiction data (EU Kids Online survey, 2010); and mortality data (European Detailed Mortality Database, 2010 or the latest year if not available) of 24 European countries. Correlations were found using quasi-Poisson regression. Countries' prevalence rates of psychiatric problems (European Social Survey Round 3 and 6, 2006 and 2012) were used to test for possible spuriousness. This study finds that countries with higher rates of cyberbullying were more likely to have a higher incidence of unnatural child death. A 1 percent rise in the prevalence of cyberbullying translated into a 28% increase in risk of unnatural child death (95% CI: 2%-57%). No evidence was found to substantiate confounding effect of the national prevalence of depressive symptoms or traditional bullying. Explanations are given for the findings. We conclude that intervention programs designed to serve as precautionary measures for risk minimisation should be considered.

  11. Exploring the relationship between cyberbullying and unnatural child death: an ecological study of twenty-four European countries

    Science.gov (United States)

    2014-01-01

    Background Internet risk has been recognised as a child safety problem, but evidence is insufficient to conclude that a child’s online risk exposure can lead to physical harm. This study aims to explore the ecological relationship between Internet risk exposure and unnatural child death. Methods Multiple secondary data sources were used: online exposure to content about self-harm, cyberbullying, and Internet addiction data (EU Kids Online survey, 2010); and mortality data (European Detailed Mortality Database, 2010 or the latest year if not available) of 24 European countries. Correlations were found using quasi-Poisson regression. Countries’ prevalence rates of psychiatric problems (European Social Survey Round 3 and 6, 2006 and 2012) were used to test for possible spuriousness. Results This study finds that countries with higher rates of cyberbullying were more likely to have a higher incidence of unnatural child death. A 1 percent rise in the prevalence of cyberbullying translated into a 28% increase in risk of unnatural child death (95% CI: 2%-57%). No evidence was found to substantiate confounding effect of the national prevalence of depressive symptoms or traditional bullying. Conclusions Explanations are given for the findings. We conclude that intervention programs designed to serve as precautionary measures for risk minimisation should be considered. PMID:25079144

  12. Effects of Twenty-four Move Shadow Boxing Combined with psychosomatic relaxation on Depression and Anxiety in Patients with Type-2 Diabetes.

    Science.gov (United States)

    Zheng, Yingying; Zhou, Yiyi; Lai, Qiujia

    2015-06-01

    The aim of the current study was to observe the effects of Twenty-four Move Shadow Boxing combined with psychosomatic relaxation on depression and anxiety in patients with Type-2 Diabetes. One hundred and twenty (120) patients with Type-2 Diabetes and depressive/anxious symptoms were divided into intervention group (60 cases) and control group (60 cases) according to the minimum distribution principle of unbalanced indicators. Twenty-four Move Shadow Boxing group used this intervention combined with psychosomatic relaxation. Control group underwent conventional treatment. All the patients in the two groups completed the Self-rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) before and after treatment. Among the 52 people included in the statistical analysis, the recovery rate was 13.3%. The differences between depression and anxiety scores in the intervention group before and after treatment were statistically significant (PBoxing and psychosomatic relaxation has a beneficial auxiliary therapeutic effect on depression and anxiety accompanying Type-2 Diabetes.

  13. The 49th hour: analysis of a follow-up medication and vaccine dispensing field test.

    Science.gov (United States)

    Puerini, Raymond; Caum, Jessica; Francis, Natalie; Alles, Steven

    2015-01-01

    Anthrax response plans, exercises, and assessments over the past decade have focused almost exclusively on the first 48 hours of the public health response following a jurisdiction-wide exposure and provision of an initial 10-day supply of antibiotics from the Strategic National Stockpile (SNS). But mass dispensing of the subsequent 50-day course of antibiotics and administration of the 3-dose vaccine series have received considerably less attention, although these follow-up activities may prove even more complex. In 2014, the Philadelphia Department of Public Health (PDPH) made its first foray into this next frontier of mass prophylaxis planning by: (1) researching patient safety and adherence considerations relevant to the antibiotics in the SNS; (2) designing a model for a second-visit antibiotic and vaccine point of dispensing (POD), including development of an enhanced screening protocol that assumes a higher level of medical responsibility; and (3) field testing this model during a real seasonal influenza vaccination clinic to assess throughput and accuracy and to evaluate the resources needed to operationalize this model. While the observations and data presented here provide some framework for local long-term mass prophylaxis planning efforts, many areas remain undefined, including the distribution of responsibilities among the public health and healthcare communities to ensure patient safety. In addition to presenting findings, the larger intent of this article is to initiate a dialogue with other stakeholders at the local, state, and federal levels to advance long-term mass prophylaxis planning.

  14. Neonatal gut function, measured by the one hour blood D (+) xylose test: influence of gestational age and size.

    OpenAIRE

    Ducker, D A; Hughes, C A; Warren, I.; McNeish, A S

    1980-01-01

    D(+) Xylose absorption, assessed by one hour blood xylose levels, has been measured after intraduodenal infusion of the sugar in 35 infants of differing gestational age and size. The test was performed between the 2nd and 6th days of life. Full-term appropriately grown infants had higher blood xylose levels (1.41+/-0.07 mmol/l) at one hour than pre-term appropriately grown infants (1.17+/-0.07 mmol/l; P less than 0.05), or 'light for dates' infants, both full-term (0.73+/-0.06 mmol/l; P less ...

  15. What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

    Directory of Open Access Journals (Sweden)

    Kai Niu

    2015-12-01

    Full Text Available Coherent anti-Stokes Raman spectroscopy (CARS is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

  16. What are the intensities and line-shapes of the twenty four polarization terms in coherent anti-Stokes Raman spectroscopy?

    Energy Technology Data Exchange (ETDEWEB)

    Niu, Kai [School of Science, Tianjin University of Technology and Education, Tianjin, 300222 (China); Lee, Soo-Y., E-mail: sooying@ntu.edu.sg [Division of Physics & Applied Physics, and Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore)

    2015-12-15

    Coherent anti-Stokes Raman spectroscopy (CARS) is conventionally described by just one diagram/term where the three electric field interactions act on the ket side in a Feynman dual time-line diagram in a specific time order of pump, Stokes and probe pulses. In theory, however, any third-order nonlinear spectroscopy with three different electric fields interacting with a molecule can be described by forty eight diagrams/terms. They reduce to just 24 diagrams/terms if we treat the time ordering of the electric field interactions on the ket independently of those on the bra, i.e. the ket and bra wave packets evolve independently. The twenty four polarization terms can be calculated in the multidimensional, separable harmonic oscillator model to obtain the intensities and line-shapes. It is shown that in fs/ps CARS, for the two cases of off-resonance CARS in toluene and resonance CARS in rhodamine 6G, where we use a fs pump pulse, a fs Stokes pulse and a ps probe pulse, we obtain sharp vibrational lines in four of the polarization terms where the pump and Stokes pulses can create a vibrational coherence on the ground electronic state, while the spectral line-shapes of the other twenty terms are broad and featureless. The conventional CARS term with sharp vibrational lines is the dominant term, with intensity at least one order of magnitude larger than the other terms.

  17. Fluidized-bed combustion 1000-hour test program. Volume IV. Engineering details and post-test inspections

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, A. G.; Barker, S. N.; Phillips, R. N.; Pillai, K. K.; Raven, P.; Wood, P.

    1981-09-01

    Volume IV of the report on the 1000 hour programme consists of three appendices giving details of the enginmering/construction aspects of the plant and reports from Stal-Laval Turbin A.B. Appendix N has been entered individually. (LTN)

  18. Studies on the T sub 3 suppression test with reference to the thyrodial sup 123 I uptake in Graves' disease; Comparison of 24-hour and 3-hour uptake

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Takahiko; Kobayashi, Isao; Yamaguchi, Yoshiyuki; Iwashita, Akira; Inukai, Toshihiko; Ohshima, Kihachi; Shimomura, Yohnosuke; Kobayashi, Setsuo (Gunma Univ., Maebashi (Japan). School of Medicine)

    1990-06-01

    Eighty-three patients with Graves' disease had been treated with methylmercaptoimidazole (MMI). They were prescribed a maintenance dose of antithyroid drug (MMI, 5 mg/day) at the time of a T{sub 3} suppression test. The 3-hour and 24-hour thyroidal {sup 123}I uptake after T{sub 3} administration (75 {mu}g/day, 2 weeks) were measured (post T{sub 3} uptake). In 38 patients whose post T{sub 3} uptake was below 35% in post T{sub 3} 24-hour uptake, treatment was stopped. The T{sub 3} suppression test was then repeated 1 and 3 months later. During a one-year follow up, 26 remained well, while 12 relapsed within 6 to 12 months. We have observed a good correlation between 3-hour uptake and 24-hour uptake of {sup 123}I after T{sub 3} administration (r=0.847, p<0.001). In 38 patients who showed positive T{sub 3} suppression, most patients with MMI withdrawal produced a marked overshoot of post T{sub 3} 3-hour and 24-hour uptake at one month. Retrospective analysis indicated that there was no significant difference in circulating thyroid hormone levels between remission and relapse groups. The present study provides evidence that 3-hour uptake values are able to be substituted for 24-hour uptake values during a T{sub 3} suppression test. In addition, overshoot of thyroidal uptake after antithyroid drug withdrawal was observed in 3-hour values, similar to 24-hour values. (author).

  19. Hourly test reference weather data in the changing climate of Finland for building energy simulations

    Directory of Open Access Journals (Sweden)

    Kirsti Jylhä

    2015-09-01

    Full Text Available Dynamic building energy simulations need hourly weather data as input. The same high temporal resolution is required for assessments of future heating and cooling energy demand. The data presented in this article concern current typical values and estimated future changes in outdoor air temperature, wind speed, relative humidity and global, diffuse and normal solar radiation components. Simulated annual and seasonal delivered energy consumptions for heating of spaces, heating of ventilation supply air and cooling of spaces in the current and future climatic conditions are also presented for an example house, with district heating and a mechanical space cooling system. We provide details on how the synthetic future weather files were created and utilised as input data for dynamic building energy simulations by the IDA Indoor Climate and Energy program and also for calculations of heating and cooling degree-day sums. The information supplied here is related to the research article titled “Energy demand for the heating and cooling of residential houses in Finland in a changing climate” [1].

  20. On the Idyllic Realm in the Twenty-four Poetic Genres%论«二十四诗品»的休闲境界

    Institute of Scientific and Technical Information of China (English)

    孙敏明

    2016-01-01

    «二十四诗品»不仅是司空图论诗歌艺术风格类型的文学理论作品,也是优美的诗歌作品。综观«二十四诗品»,最重要的是通过对纯洁本性的累积、回归、体悟而达到对“真”“中”“虚”的葆有。«二十四诗品»为我们展示了诗意栖居的生活,也体现了古人内外双修,体验式的生活方式,从而能启示活在当下、顺任自然的诗意人生,启示我们思考如何更聪明地休闲,追求与道同体的永恒境界。%The Twenty-four Poetic Genres written by Si kongtu is not only a theoretic book on the po-etic genres,but also a poetic work itself.Overview the whole book,the essence is to maintain the"true""intrinsic"and"virtual"quality through the accumulation,regression and comprehension of pure nature. It revealed the idyllic settings of our ancestors with the poetic life to inspire us to take relaxation naturally and cleverly for the pursuit of eternal realm of life.

  1. The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea

    Directory of Open Access Journals (Sweden)

    Reeder John C

    2008-04-01

    Full Text Available Abstract Background In Papua New Guinea (PNG, combination therapy with amodiaquine (AQ or chloroquine (CQ plus sulphadoxine-pyrimethamine (SP was introduced as first-line treatment against uncomplicated malaria in 2000. Methods We assessed in vivo treatment failure rates with AQ+SP in two different areas in PNG and twenty-four molecular drug resistance markers of Plasmodium falciparum were characterized in pre-treatment samples. The aim of the study was to investigate the association between infecting genotype and treatment response in order to identify useful predictors of treatment failure with AQ+SP. Results In 2004, Day-28 treatment failure rates for AQ+SP were 29% in the Karimui and 19% in the South Wosera area, respectively. The strongest independent predictors for treatment failure with AQ+SP were pfmdr1 N86Y (OR = 7.87, p pfdhps A437G (OR = 3.44, p pfcrt K76T, A220S, N326D, and I356L did not help to increase the predictive value, the most likely reason being that these mutations reached almost fixed levels. Though mutations in SP related markers pfdhfr S108N and C59R were not associated with treatment failure, they increased the predictive value of pfdhps A437G. The difference in treatment failure rate in the two sites was reflected in the corresponding genetic profile of the parasite populations, with significant differences seen in the allele frequencies of mutant pfmdr1 N86Y, pfmdr1 Y184F, pfcrt A220S, and pfdhps A437G. Conclusion The study provides evidence for high levels of resistance to the combination regimen of AQ+SP in PNG and indicates which of the many molecular markers analysed are useful for the monitoring of parasite resistance to combinations with AQ+SP.

  2. Safety considerations for continuous hydrogen production test apparatus with capacity of 50 N-litter hydrogen per hour

    Energy Technology Data Exchange (ETDEWEB)

    Onuki, Kaoru; Akino, Norio; Shimizu, Saburo; Nakajima, Hayato; Higashi, Shunichi; Kubo, Shinji [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    2001-03-01

    Since the thermochemical hydrogen production Iodine-Sulfur process decomposes water into hydrogen and oxygen using toxic chemicals such as sulfuric acid, iodine and hydriodic acid, safety considerations are very important in its research and development. Therefore, before construction of continuous hydrogen production test apparatus with capacity of 50 N-litter hydrogen per hour, comprehensive safety considerations were carried out to examine the design and construction works of the test apparatus, and the experimental plans using the apparatus. Emphasis was given on the safety considerations on prevention of breakage of glasswares and presumable abnormalities, accidents and their countermeasures. This report summarizes the results of the considerations. (author)

  3. Preliminary indications for antibiotic susceptibility tests in less than six hour in positive blood cultures

    Directory of Open Access Journals (Sweden)

    Vesselina Kroumova

    2010-03-01

    Full Text Available A rapid determination of the antibiotic susceptibility patterns of pathogens responsible for sepsis represents a significant milestone for a timely correct antibiotic therapy.The system HB&L® (ALIFAX allows reduced time in the detection of bacterial growth and consequently is able to detect the growth or absence of certain microorganisms in the presence of a given antibiotic. In this study three system for rapid antibiotic susceptibility tests among bacteria isolated from blood were compared: HB&L® (ALIFAX,VITEK®2 (bioMérieux and essays Etest® (bioMérieux. Present findings indicate that HB&L® (ALIFAX is rapid reliable instrument that may support the clinician for a rapid and appropriate treatment, particularly in the critical patient.

  4. Progress of the ELISE test facility: towards one hour pulses in hydrogen

    Science.gov (United States)

    Wünderlich, D.; Fantz, U.; Heinemann, B.; Kraus, W.; Riedl, R.; Wimmer, C.; the NNBI Team

    2016-10-01

    In order to fulfil the ITER requirements, the negative hydrogen ion source used for NBI has to deliver a high source performance, i.e. a high extracted negative ion current and simultaneously a low co-extracted electron current over a pulse length up to 1 h. Negative ions will be generated by the surface process in a low-temperature low-pressure hydrogen or deuterium plasma. Therefore, a certain amount of caesium has to be deposited on the plasma grid in order to obtain a low surface work function and consequently a high negative ion production yield. This caesium is re-distributed by the influence of the plasma, resulting in temporal instabilities of the extracted negative ion current and the co-extracted electrons over long pulses. This paper describes experiments performed in hydrogen operation at the half-ITER-size NNBI test facility ELISE in order to develop a caesium conditioning technique for more stable long pulses at an ITER relevant filling pressure of 0.3 Pa. A significant improvement of the long pulse stability is achieved. Together with different plasma diagnostics it is demonstrated that this improvement is correlated to the interplay of very small variations of parameters like the electrostatic potential and the particle densities close to the extraction system.

  5. Metabolic effects of isoenergetic nutrient exchange over 24 hours in relation to obesity in women.

    Science.gov (United States)

    Lean, M E; James, W P

    1988-01-01

    Twenty-four hour whole body indirect calorimetry has been used to study the effects of feeding, during a sedentary test day, isoenergetic diets which varied in fat (3 or 40 per cent of total energy) and carbohydrate (82 or 45 per cent) content. Three groups of women were studied: lean, obese and 'post-obese' after slimming. Energy expenditure was greater in absolute terms in the obese women. Twenty-four hour energy expenditure was lower by only 3-7 per cent when fasting compared to that when fed to achieve energy balance. There were no large differences in energy expenditure between the two diets or between the groups but the thermogenic effect of the high carbohydrate diet was significantly greater than that of the high fat diet (5.8 vs 3.5 per cent of energy expenditure: P less than 0.01). The post-obese tended to have lower energy expenditure per kg FFM than controls when fasting and when high-fat fed, but this pattern was not shown by the obese. Sleeping energy expenditure was particularly low in the post-obese group when high-fat fed. Dirunal variations in RQ appear to show more marked rise in morning RQ from the nocturnal minimum in the obese and post-obese, which might be evidence for an energy-saving mechanism through greater availability of stored dietary carbohydrate.

  6. Clinical Significance of Low Result of 1-hour 50-g Glucose-Challenge Test in Pregnant Women.

    Science.gov (United States)

    Oawada, Nozomi; Aoki, Shigeru; Sakamaki, Kentaro; Obata, Soichiro; Seki, Kazuo; Hirahara, Fumiki

    2017-08-22

    To examine the effect of low glucose value on the 1-hour 50-g Glucose Challenge Test (GCT) on neonatal body weight in low-risk Asian singleton pregnant women. We retrospectively analyzed women who delivered a singleton neonate at term at a tertiary center and underwent GCT at 24-28 weeks of gestation between June 2001 and June 2015. Low GCT group was defined as result (Standardized coefficient (β)(β); GCT 0.071, height 0.188, prepregnancy BMI 0.143). Neonatal body weight was only slightly influenced by low GCT result, but markedly influenced by maternal physique, such as height and prepregnancy BMI.

  7. Twenty Four-Hour Exposure to a 0.12 THz Electromagnetic Field Does Not Affect the Genotoxicity, Morphological Changes, or Expression of Heat Shock Protein in HCE-T Cells

    Science.gov (United States)

    Koyama, Shin; Narita, Eijiro; Shimizu, Yoko; Shiina, Takeo; Taki, Masao; Shinohara, Naoki; Miyakoshi, Junji

    2016-01-01

    To investigate the cellular effects of terahertz (THz) exposure, human corneal epithelial (HCE-T) cells derived from human eye were exposed to 0.12 THz radiation at 5 mW/cm2 for 24 h, then the genotoxicity, morphological changes, and heat shock protein (Hsp) expression of the cells were examined. There was no statistically significant increase in the micronucleus (MN) frequency of cells exposed to 0.12 THz radiation compared with sham-exposed controls and incubator controls, whereas the MN frequency of cells treated with bleomycin for 1 h (positive control) did increase significantly. Similarly, there were no significant morphological changes in cells exposed to 0.12 THz radiation compared to sham-exposed controls and incubator controls, and Hsp expression (Hsp27, Hsp70, and Hsp90α) was also not significantly different between the three treatments. These results indicate that exposure to 0.12 THz radiation using the present conditions appears to have no or very little effect on MN formation, morphological changes, and Hsp expression in cells derived from human eye. PMID:27527204

  8. Twenty Four-Hour Exposure to a 0.12 THz Electromagnetic Field Does Not Affect the Genotoxicity, Morphological Changes, or Expression of Heat Shock Protein in HCE-T Cells.

    Science.gov (United States)

    Koyama, Shin; Narita, Eijiro; Shimizu, Yoko; Shiina, Takeo; Taki, Masao; Shinohara, Naoki; Miyakoshi, Junji

    2016-08-05

    To investigate the cellular effects of terahertz (THz) exposure, human corneal epithelial (HCE-T) cells derived from human eye were exposed to 0.12 THz radiation at 5 mW/cm² for 24 h, then the genotoxicity, morphological changes, and heat shock protein (Hsp) expression of the cells were examined. There was no statistically significant increase in the micronucleus (MN) frequency of cells exposed to 0.12 THz radiation compared with sham-exposed controls and incubator controls, whereas the MN frequency of cells treated with bleomycin for 1 h (positive control) did increase significantly. Similarly, there were no significant morphological changes in cells exposed to 0.12 THz radiation compared to sham-exposed controls and incubator controls, and Hsp expression (Hsp27, Hsp70, and Hsp90α) was also not significantly different between the three treatments. These results indicate that exposure to 0.12 THz radiation using the present conditions appears to have no or very little effect on MN formation, morphological changes, and Hsp expression in cells derived from human eye.

  9. Design and Testing of a 2-Hour Oxygen Prebreathe Protocol for Space Walks from the International Space Station

    Science.gov (United States)

    Gernhardt, Michael L.; Conkin, J.; Foster, P. P.; Pilmanis, A. A.; Butler, B. D.; Beltran, E.; Fife, C. E.; Vann, R. D.; Gerth, W. A.; Loftin, K. C.; hide

    2000-01-01

    To develop and test a 2-hour prebreathe protocol for performing extravehicular activities (EVAs) from the International Space Station (ISS). Combinations of adynamia (non-walking), prebreathe exercise, and space suit donning options (10.2 vs. 14.7 psi) were evaluated, against timeline and consumable contraints to develop an operational 2- hour prebreathe protocol. Prospective accept/reject criteria were defined for decompression sickness (DCS) and venous gas emboli (VGE) from analysis of historical DCS data, combined with risk management of DCS under ISS mission circumstances. Maximum operational DCS levels were defined based on protecting for EVA capability with two crew-members at 95% confidence, throughout ISS lifetime (within the constraints of NASA DCS disposition policy JPG 1800.3). The accept/reject limits were adjusted for greater safety based on analysis of related medical factors. Monte-Carlo simulation was performed to design a closed sequential, multi-center human trial. Protocols were tested with 4 different prebreathe exercises (Phases I-IV), prior to exposure to 4.3 psi for 4 hrs. Subject selection, Doppler monitoring for VGE, test termination criteria, and DCS definitions were standardized. Phase I: upper and lower body exercises using dual-cycle ergometry (75% VO2 max for 10 min). Phase II: ergometry plus 24 min of light exercise (simulating space-suit preparations). Phase III: same 24 min of light exercise but no ergometry, and Phase IV: 56 min of light exercise without ergometry. A prebreathe procedure was accepted if, at 95% confidence, the incidence of DCS was less than 15% (with no Type II DCS), and Grade IV VGE was less than 20%.

  10. Biotype identification and epidemiological analysis of twenty-four Brucella strains%24株布鲁菌的种型鉴定和流行病学分析

    Institute of Scientific and Technical Information of China (English)

    张磊; 屈平华; 吴尚为; 陈经雕

    2016-01-01

    Objective To identify the biotype and analyze the epidemiological characteristics of twentyfour Brurella strains from the primary hospitals in Guangdong Province.Methods The twenty-four Brucella strains,collected from Oct.2009 to Oct.2015,were identified by routine biochemical methods,VITEK 2 COMPACT automatic microbial identification analyzer,16S rRNA gene sequencing and biology phenotype based on serological and bacteriophages lysis test.The etiology was analyzed based on clinical data,biotypes of the isolates and other clinical information.Results All of the twenty-four strains were Gram-negative coccobacilli,including two strains of Brucella suis biotype Ⅱ,four strains of Brucella melitensis biotype Ⅰ and eighteen strains of Brucella melitensis biotype Ⅲ.By GN card of VITEK 2 COMPACT automatic microbial identification analyzer,one strain was mistaken as Bordetella bronchiseptica and two strains were mistaken as Ochrobaetrum anthropi.The 16S rRNA gene sequencing showed they were high homology to Ochrobactrum intermedium and Ochrobaetrum anthropi,which completely excluded the possibility of Bordetella bronchiseptica.Tbe clinical data showed that all of the twenty-four patients were adults with an average age of 49.0 years old,men and women were twelve people respectively,with no significant gender differences and no occupational exposure,which presenting a wide and diverse range of nonspecific clinical signs and symptoms,but brucellosis was not aware of by the physician.Conclusion Brucella melitensis biotype Ⅲ is the main pathogen of brucellosis,with the characteristics of sporadic outbreak and occult infection in the primary hospitals in Guangdong Province.%目的 对广东省基层地区24株布鲁菌进行种型鉴定和流行病学分析.方法 对24株来自于2009年10月至2015年10月广东省基层医院血培养阳性的布鲁菌进行传统生化鉴定、VITEK 2仪器鉴定、16S rRNA基因测序、血清学试验和噬菌体试验,比较不

  11. Giorgio Vasari and the Image of the Hour

    Science.gov (United States)

    Gahtan, M. W.

    2011-06-01

    Giorgio Vasari created the first allegories of the twenty-four hours in the mid-16th century. This essay explores Vasari's novel images in the context of his visual and literary sources, the rising importance of household timepieces, and the artist's other works and writings. Although a focused study of a single motif within Vasari's oeuvre, it has implications for the broader transformation time perception and its psychological dimensions then taking place in Early Modern Europe.

  12. Determination of the Chronic Mammalian Toxicological Effects of TNT (twenty-Four Month Chronic Toxicity/Carcinogenicity Study of Trinitrotoluene (TNT) in the Fischer 344 Rat). Volume 1

    Science.gov (United States)

    1984-12-01

    4 SELJPITV :ZASSI rICA TION Z~ THIS HACE I -i - ~ - - . . - Contract No. DAMD17-79-C-9120 IITRI Project No. L6116 Study No. 9...for cataract formation (Table 1). Al Test Week 103, a higher incidence of cataracts was observed in el tesi groups. Although the incidences of

  13. Twenty-four mini-pool HCV RNA screening in a routine clinical virology laboratory setting: a six-year prospective study.

    Science.gov (United States)

    Seme, Katja; Mocilnik, Tina; Poljak, Mario

    2011-01-01

    The usefulness of combined anti-HCV and 24 mini-pool HCV RNA screening strategy was re-evaluated after a six-year continuous routine use in a clinical virology laboratory, at which more than half of newly diagnosed hepatitis C patients are intravenous drug users. Pools of 24 samples were prepared from 20,448 anti-HCV negative serum samples and tested using an automated commercial PCR assay with a lower limit of detection of 50 IU/ml. After detection of anti-HCV negative/HCV RNA positive patients, responsible physicians provided follow-up samples. Thirty-eight (0.19%) anti-HCV negative/HCV RNA positive samples from 30 patients (28 intravenous drug users) were detected. Follow-up samples were available for 27/30 patients. Twenty, six and one patient seroconverted in the second, third and fourth available samples, respectively. The interval between the first HCV RNA positive and the first available anti-HCV positive sample was 17-517 days. The costs of detecting a single anti-HCV negative/HCV RNA positive patient were 1227 Euros. Combined anti-HCV and 24 mini-pool HCV RNA screening is a useful and cost effective strategy, not only in blood-transfusion settings but also in a routine clinical virology laboratory, at which a significant proportion of the tested population belongs to a high-risk population. Copyright © 2010 Elsevier B.V. All rights reserved.

  14. GOES Infrared and Reflectance 0-1 hour Lightning Initiation Indicators: Development and Initial Testing within a Convective Nowcasting System

    Science.gov (United States)

    Mecikalski, J. R.; Harris, R.; MacKenzie, W.; Durkee, P. A.; Iskenderian, H.; Bickmeier, L.; Nielsen, K. E.

    2010-12-01

    Within cumulus cloud fields that develop in conditionally unstable air masses, only a fraction of the cumuli may eventually develop into deep convection. Identifying which of these convective clouds most likely to generate lightning often starts with little more than a qualitative visual satellite analysis. The goal of this study is to identify the observed satellite infrared (IR) signatures associated with growing cumulus clouds prior to the first lightning strike, so-called lightning initiation (LI). This study quantifies the behavior of ten Geostationary Operational Environmental Satellite (GOES-12) IR interest fields in the 1-hour in advance of LI. A total of 172 lightning-producing storms that occurred during the 2009 convective season are manually tracked and studied over four regions: Northern Alabama, Central Oklahoma, the Kennedy Space Center and Washington D.C. Four-dimensional and cloud-to-ground lightning array data provide a total cloud lightning picture (in-cloud, cloud-to-cloud, cloud-to-air, cloud-to-ground) and thus precise LI points for each storm in both time and space. Statistical significance tests are conducted on observed trends for each of the ten LI fields to determine the unique information each field provides in terms of behavior prior to LI. Eight out of ten LI fields exhibited useful information at least 15 min in advance of LI, with 35 min being the average. Statistical tests on these eight fields are compared for separate large geographical areas. IR temperature thresholds are then determined as an outcome, which may be valuable when implementing a LI prediction algorithm into real-time satellite-based systems. The key LI indicators from GOES IR data (as well as 3.9 μm reflectance) will be presented. Beginning in 2010, the feasibility of using the satellite-based LI indicators found in the above analysis to forecast first lightning will be assessed within the Federal Aviation Administration’s (FAA) CoSPA nowcasting system. The goal

  15. Effects of Thai Dancing on Median Neurodynamic Response During 4-Hour Computer Use.

    Science.gov (United States)

    Mekhora, Keerin; Septham, Chatdao; Jalayondeja, Wattana

    2015-06-01

    To investigate the effects of Thai dancing on median neurodynamic response during 4-hour computer use. Twenty-four healthy participants aged 20-30 years performed 5 minutes of Thai dancing including Prom See Na, Yoong Fon Hang, Sod Soy Mala, Lor Keaw and Cha Nee Rai Mai during a 10-minute break of 4-hour computer use. All participants were assessed for nerve tension by elbow range of motion ofupper limb neurodynamic test 1 (ULNT1) and components of quick test. The discomfort was measured by visual analogue discomfort scale (VADS). These measurements were assessed before and after computer work. The statistical analyses employed paired t-test for continuous outcome and Friedman's test. The median nerve tension (indicated by elbow range of motion) was significantly reduced at before and after work, when 5 minutes of Thai dancing was introduced during the break. While components of the quick test emphasized that Thai dance immediately helped reduce the median nerve tension. The VADS in eight body areas increased over the period of 4 hours, but decreased after performing Thai dancing (pdancing helped relieve median nerve tension and body discomfort. It may be recommended as an exercise during break for computer users who continuously work to prevent WMSDs.

  16. Neurocognitive performance and behavioral symptoms in patients with attention-deficit/hyperactivity disorder during twenty-four months of treatment with methylphenidate.

    Science.gov (United States)

    Wang, Liang-Jen; Chen, Chih-Ken; Huang, Yu-Shu

    2015-04-01

    This study investigated the trends in neurocognitive function and behavioral symptoms among patients with attention-deficit/hyperactivity disorder (ADHD) during 24 months of treatment with methylphenidate in a clinical setting. Study participants consisted of 181 ADHD patients with a mean age of 13.4±2.5 years (ages ranged from 8 to 18 years; 151 boys and 30 girls) who were prescribed oral short-acting methylphenidate two or three times daily, with each dose ranging between 0.3 and 1.0 mg/kg. At baseline and 6, 12, 18, and 24 months from baseline, neurocognitive function was assessed using the Test of Variables of Attention (TOVA) on the day the patient was off medication, and behavioral symptoms were evaluated using the Swanson, Nolan, and Pelham Version IV Scale for ADHD (SNAP-IV) parent form, the SNAP-IV teacher form, and the ADHD-Rating Scale (completed by a child psychiatrist). Of the 181 ADHD patients at the initial visit, 103 (56.9%) completed the study. During the 24-month methylphenidate treatment, only the commission errors in TOVA significantly improved; however, the omission errors, response time, response time variability, response sensitivity, and ADHD score did not. The behavioral symptoms of ADHD, observed by various informants, all declined substantially, and were significantly correlated with each other during the long-term follow-up. The severity of teacher ratings was lower than that of parent and psychiatrist ratings. However, the teacher-rated inattention symptoms showed the strongest correlations with TOVA performance. Findings suggest that neurocognitive deficits in ADHD patients, except inhibition ability, might be long lasting in realistic settings. In addition, obtaining behavior profile assessments from multiple informants, especially from teachers, is vital for establishing a complete understanding of ADHD patients.

  17. Development, characterization, and epitope mapping of a panel of twenty-four monoclonal antibodies specific for human inducible nitric oxide synthase.

    Science.gov (United States)

    Webber, Robert J; Rodriguez, John G; Webber, Douglas S; Dunnebacke, Thelma H

    2005-02-01

    A panel of monoclonal antibodies (MAbs) to human inducible nitric oxide synthase (hiNOS) has been developed. By isotype analysis of the MAbs cloned from the 24 different positive hybridomas, 13 were determined to be mouse IgG1, two were mouse IgG2a, two were mouse IgG2b, and the seven others were mouse IgM antibodies: all contained kappa light chains. The anti-hiNOS MAbs were initially characterized by ELISA, RIA, Western blot, and immunocytochemistry, and then they were epitope mapped using synthetic peptides and a three-step mapping procedure. In the first step, each of the 24 MAbs was tested by indirect ELISA for binding to 96 overlapping 18-amino acid-long peptides that span the entire 1153-amino acid length of hiNOS. Eight IgG class anti-hiNOS MAbs were found to bind to one of five different peptides. In the second step, a series of amino terminal and carboxyl terminal truncated peptides were synthesized for each of the five peptides to which one or more of the MAbs bound. Each of the eight anti-hiNOS MAbs was found to bind to the truncated peptides with a unique specificity that identified the amino acid segment involved in binding. The third step in the epitope mapping process utilized three series of overlapping 5-, 6-, 7-, 8-, and 9-amino acid-long peptides for each of these segments and identified the exact amino acids of hiNOS involved in antibody binding. Anti-hiNOS MAbs 2A1-F8, 2D2-B2, 21C10-1D10, and 24B10-2C7 were found to be especially useful in different immunoassays.

  18. 论《二十四诗品》虚拟人物背后的“五然”理想人格%"Five Good" ldeal Personalities of the Virtual Characters of "Twenty-four Poems"

    Institute of Scientific and Technical Information of China (English)

    张猛刚

    2014-01-01

    "Taste of poetry reflects taste of life and style shows personality in the opposite way." In this sense, "Twenty-four Poems" do absolutely not mean to teach how to write poems and how to cultivate the couplet but to develop human nature to promote personality. It is the aloof personality, light life consciousness, self perfection and the acceptance of natural realization that are prominently revealed in the twenty-four kinds of mood behind the virtual figures. Those spirits have got considerable inspiration for the modern people in self-cultivation.%“诗品映衬人品,风格返现人格。”从这个意义上来说,《二十四诗品》绝对不是教我们如何作诗,如何对句,而是陶冶人的性情,求得人格上的提升。其实在二十四种意境之中,在虚拟人物背后,突出表现的是超然的人格理想、淡然的生命意识和自我完善、自然实现的精神。这对今人在修身养性方面有着极大的启示作用。

  19. Static stretching can impair explosive performance for at least 24 hours.

    Science.gov (United States)

    Haddad, Monoem; Dridi, Amir; Chtara, Moktar; Chaouachi, Anis; Wong, Del P; Behm, David; Chamari, Karim

    2014-01-01

    The aim of this study was to compare the effects of static vs. dynamic stretching (DS) on explosive performances and repeated sprint ability (RSA) after a 24-hour delay. Sixteen young male soccer players performed 15 minutes of static stretching (SS), DS, or a no-stretch control condition (CC) 24 hours before performing explosive performances and RSA tests. This was a within-subject repeated measures study with SS, DS, and CC being counterbalanced. Stretching protocols included 2 sets of 7 minutes 30 seconds (2 repetitions of 30 seconds with a 15-second passive recovery) for 5 muscle groups (quadriceps, hamstring, calves, adductors, and hip flexors). Twenty-four hours later (without any kind of stretching in warm-up), the players were tested for the 30-m sprint test (with 10- and 20-m lap times), 5 jump test (5JT), and RSA test. Significant differences were observed between CC, SS, and DS with 5JT (F = 9.99, p effect size [ES] = 0.40), 10-m sprint time (F = 46.52, p stretching protocols in the total time (F = 1.55, p > 0.05), average time (F = 1.53, p > 0.05), and fastest time (F = 2.30, p > 0.05), except for the decline index (F = 3.54, p negative effect on explosive performances up to 24 hours poststretching with no major effects on the RSA. Conversely, the DS of the same muscle groups are highly recommended 24 hours before performing sprint and long-jump performances. In conclusion, the positive effects of DS on explosive performances seem to persist for 24 hours.

  20. On the Beauty of Twenty-four Poetry Style%美感体验中的三维透视--论《二十四诗品》朦胧美

    Institute of Scientific and Technical Information of China (English)

    吕甜

    2016-01-01

    A lot of researches have been done about the aesthetics of the Twenty-four Poetry Style for several years. The highly theoretical aesthetic researches which include framing aesthetics, thought aesthetics, ecological esthetics, poetic aesthetics and ideal aesthetics make this book more attractive. But on the other hand, some expansion exists in the aesthetic value of this book because the researchers add their aesthetic theories to the theoretic distillation of the book. In this article, the directly perceived dim beauty and the burden of dim beauty have been analyzed from the experience of the aesthetic perception, which will clearly display the beauty of the Twenty-four Poetry Style.%历年来关于《二十四诗品》的美学研究是层出不穷的,从架构美学到思想美学到生态美学到诗歌美学到理想美学等等,这种高度理论性的美学研究使得整部著作更加具有魅力性。但是这种提炼浓缩后的理论升华在无形中也附加上了论者们的美学理想,使得《二十四诗品》美学价值或多或少地存在着“膨胀”的现象。文章将从美感体验出发,旨在挖掘分析能被直接感知的朦胧美和美的朦胧负担,让《二十四诗品》的美变得更加有迹可循。

  1. Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.

    Science.gov (United States)

    Baldwin, H A; File, S E

    1989-01-01

    Rats were chronically treated with chlordiazepoxide (CDP 10 mg/kg/day) or vehicle for 27 days. Twenty-four hours after their last dose, they received flumazenil (4 mg/kg) or vehicle and were tested in the social interaction test, in a low-light, familiar arena. CDP withdrawal significantly reduced the time spent in social interaction compared with controls, indicating an anxiogenic withdrawal response. This was completely reversed by flumazenil. A second group received CDP for 27 days and, in addition, received a single dose of flumazenil (4 mg/kg) 6 days before testing. Flumazenil prevented the development of the anxiogenic withdrawal response in these rats.

  2. [Cardiopulmonary stress testing in children who have had congenital heart disease surgery. Physical exercise recommendations during school hours].

    Science.gov (United States)

    Serra-Grima, Ricard; Doñate, Maite; Borrás, Xavier; Rissech, Miquel; Puig, Teresa; Albert, Dimpna C; Bartrons, Joaquim; Gran, Ferran; Manso, Begoña; Ferrer, Queralt; Girona, Josep; Casaldáliga, Jaume; Subirana, Maite

    2011-09-01

    To analyze and discover if stress testing with exhaled gases in children who have had congenital heart surgery is useful so we could make physical exercise recommendations according to heart disease, type of surgery performed, present hemodynamic state and level of exercise practiced. Prospective study of 108 children, who performed stress testing with exhaled gases, electrocardiogram monitoring and blood pressure. A questionnaire was used to obtain variables concerning heart disease, surgery, present functional condition and level of exercise practiced. Exercise recommendations were given after stress testing, and after a year 35 patients answered a questionnaire. There were significant differences between lesion severity and heart rate at rest and during effort, systolic pressure at rest and during effort, oxygen uptake, oxygen pulse, carbon dioxide production and test duration. A relationship was observed between level of weekly exercise and greater oxygen uptake and test duration, but this was not observed with the underlying heart disease. We observed that best performance occurred with fast repairing for 59 children with cyanotic heart disease. Increased exercise level was recommended for 48 children. The cardiopulmonary function study allows us to examine the physical performance of children who have had congenital heart surgery and provides us with important data so that we can recommend better physical exercise planning. Copyright © 2011 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  3. Rapid Blue-Carba test: reduction in the detection time of carbapenemases performed from a 4-hour bacterial lawn.

    Science.gov (United States)

    Nastro, Marcela; Ayora, Melisa; García, Susana; Vay, Carlos; Famiglietti, Ángela; Rodriguez, Carlos Hernán

    2017-06-01

    The increase in carbapenem-resistant gram-negative bacteria is a matter of concern due to the limited therapeutic options available. In severe infections caused by these isolates, the rapid detection of the mechanisms of resistance is vital. We described a slightly modified version of the Blue-Carba test, rapid Blue-Carba test, which allows the detection of carbapenemases at 4 h of incubation from a haze of bacterial growth obtained from a positive blood culture. It was able to detect carbapenemase-producing isolates (Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii) with a sensitivity and specificity of 98.1 and 100%, respectively. It is a rapid, easy-to-perform and an inexpensive technique that can be applied to routine laboratories, together with the simultaneous identification by mass spectrometry which would help to screen non-enzymatic carbapenem resistance; this method allows the detection of clinically relevant multidrug-resistant bacteria and the early implementation of accurate therapeutic interventions.

  4. Influence of the time of day and fasting duration on glucose level following a 1-hour, 50-gram glucose challenge test in pregnant women.

    Directory of Open Access Journals (Sweden)

    Panchalli Wang

    Full Text Available BACKGROUND: Previous studies have shown that the time of day (TD of glucose measurement and the fasting duration (FD influence the glucose levels in adults. Few studies have examined the effects of the TD and FD on the glucose level following a 1-hour, 50-gram glucose challenge test (GCT in pregnant women in screening for or diagnosing gestational diabetes mellitus (GDM. The objective of this study was to investigate the influence of the TD (morning, afternoon, night and the FD (the time of the last food ingestion as follows: ≤1 hour, 1-2 hours, and >2 hours by examining their combined effects on the glucose levels following a 50-gram GCT in pregnant women. METHODS AND RESULTS: We analyzed the data of 1,454 non-diabetic pregnant Taiwanese women in a prospective study. Multiple linear regression and multiple logistic regression were used to estimate the relationships between the 9 TD-FD groups and the continuous and binary glucose levels (cut-off at 140 mg/dL following a 50-gram GCT, after adjusting for maternal age, nulliparity, pre-pregnancy body mass index, and weight gain. Different TD and FD groups were associated with variable glucose responses to the 50-gram GCT, some of which were significant. The estimate coefficients (β of the TD-FD groups "night, ≤1 hr" and "night, 1-2 hr" revealed significantly lower glucose concentrations [β (95% confidence interval [CI]: -6.46 (-12.53, -0.38 and -6.85 (-12.50, -1.20] compared with the "morning, >2 hr" group. The TD-FD groups "afternoon, ≤1 hr" and "afternoon, 1-2 hr" showed significantly lower odds ratios (OR of a positive GCT; the adjusted ORs (95% CI were 0.54 (0.31-0.95 and 0.58 (0.35-0.96, respectively. CONCLUSIONS: Our findings demonstrate the importance of standardizing the TD and FD for the 1-hour, 50-gram GCT. In screening for and diagnosing GDM, the TD and FD are modifiable factors that should be considered in clinical practice and epidemiological studies.

  5. Prognostic indices among hypertensive heart failure patients in Nigeria: the roles of 24-hour Holter electrocardiography and 6-minute walk test.

    Science.gov (United States)

    Mene-Afejuku, Tuoyo O; Balogun, Michael O; Akintomide, Anthony O; Adebayo, Rasaaq A

    2017-01-01

    Hypertensive heart failure (HHF) is associated with a poor prognosis. There is paucity of data in Nigeria on prognosis among HHF patients elucidating the role of 24-hour Holter electrocardiogram (ECG) in concert with other risk factors. The aim of this study was to determine the prognostic utility of 24-hour Holter ECG, the 6-minute walk test (6-MWT), echocardiography, clinical and laboratory parameters among HHF patients. A total of 113 HHF patients were recruited and followed up for 6 months. Thirteen of these patients were lost to follow-up, and as a result only 100 HHF patients were analyzed. All the patients underwent baseline laboratory tests, echocardiography, 24-hour Holter ECG and the 6-MWT. HHF patients were analyzed as "mortality vs alive" and as "events vs no-events" based on the outcome at the end of 6 months. Events was defined as HHF patients who were rehospitalized for heart failure (HF), had prolonged hospital stay or died. No-events group was defined as HHF patients who did not meet the criteria for the events group. HHF patients in the mortality group (n = 7) had significantly higher serum urea (5.71 ± 2.07 mmol/L vs 3.93 ± 1.45 mmol/L, p = 0.003) than that in those alive. After logistic regression, high serum urea conferred increased mortality risk (p = 0.035). Significant premature ventricular complexes (PVCs) on 24-hour Holter ECG following logistic regression were also significantly higher (p = 0.015) in the mortality group than in the "alive" group (n = 93) at the end of the 6-month follow-up period. The 6-minute walk distance (6-MWD) was least among the HHF patients who died (167.26 m ± 85.24 m). However, following logistic regression, the 6-MWT was not significant (p = 0.777) for predicting adverse outcomes among HHF patients. Patients in the events group (n = 41) had significantly higher New York Heart Association (NYHA) class (p = 0.001), Holter-detected ventricular tachycardia (VT; p = 0.009), Holter-detected atrial fibrillation (AF

  6. Twenty-four position tilt test for accelerometer cross-axial sensitivity compensation / Компенсация поперечной чувствительности МЭМС акселерометров с помощью тестирования статичного угла наклона, проведенного в 24-ех позициях / Kompenzacija poprečne osetljivosti MEMS akcelerometra metodom tilt-testa u 24 pozicije

    Directory of Open Access Journals (Sweden)

    Miodrag Z. Malović

    2017-07-01

    Full Text Available Cross-axial or transverse sensitivity of an accelerometer can be compensated by digital processing of the output signal. To perform this, it is necessary to determine coefficients that describe a sensor’s response to excitation experimentally. Many procedures advised by standards and scientific papers use expensive equipment which is not available in every laboratory. Therefore, a simple method is proposed, namely a variation of the static tilt test, requiring no other measuring equipment than the sensor itself and a flat surface. Results vary depending on sensor surface and housing quality, but it has been shown that cross sensitivity effects can be reduced from several percent usually associated with commercial threeaxial MEMS accelerometers down to 1% or less. / Кросс-осевая или поперечная чувствительность акселерометра может быть компенсирована цифровой обработкой выходного сигнала. При этом необходимо экспериментально определить коэффициенты реакции датчика на сигнал. Для проведения подобных мероприятий, в соответствии с рекомендациями стандартов и научных статей, применяется достаточно дорогое оборудование, которое не все лаборатории могут себе позволить. В данной связи представлен простой альтернативный метод, разновидность тестирования статичного угла наклона, не требующий никаких измерительных приборов, кроме датчика и плоской поверхности.Несмотря на то, что результаты зачастую зависят

  7. High-dose statin pretreatment decreases periprocedural myocardial infarction and cardiovascular events in patients undergoing elective percutaneous coronary intervention: a meta-analysis of twenty-four randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Le Wang

    Full Text Available BACKGROUND: Evidence suggests that high-dose statin pretreatment may reduce the risk of periprocedural myocardial infarction (PMI and major adverse cardiac events (MACE for certain patients; however, previous analyses have not considered patients with a history of statin maintenance treatment. In this meta-analysis of randomized controlled trials (RCTs, we reevaluated the efficacy of short-term high-dose statin pretreatment to prevent PMI and MACE in an expanded set of patients undergoing elective percutaneous coronary intervention. METHODS: We searched the PubMed/Medline database for RCTs that compared high-dose statin pretreatment with no statin or low-dose statin pretreatment as a prevention of PMI and MACE. We evaluated the incidence of PMI and MACE, including death, spontaneous myocardial infarction, and target vessel revascularization at the longest follow-up for each study for subgroups stratified by disease classification and prior low-dose statin treatment. RESULTS: Twenty-four RCTs with a total of 5,526 patients were identified. High-dose statin pretreatment was associated with 59% relative reduction in PMI (odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.34-0.49; P<0.00001 and 39% relative reduction in MACE (OR: 0.61; 95% CI: 0.45-0.83; P = 0.002. The benefit of high-dose statin pretreatment on MACE was significant for statin-naive patients (OR: 0.69; 95% CI: 0.50-0.95; P = 0.02 and prior low dose statin-treated patients (OR: 0.28; 95% CI: 0.12-0.65; P = 0.003; and for patients with acute coronary syndrome (OR: 0.52; 95% CI: 0.34-0.79; P = 0.003, but not for patients with stable angina (OR: 0.71; 95% CI 0.45-1.10; P = 0.12. Long-term effects on survival were less obvious. CONCLUSIONS: High-dose statin pretreatment can result in a significant reduction in PMI and MACE for patients undergoing elective PCI. The positive effect of high-dose statin pretreatment on PMI and MACE is significant for statin-naïve patients and patients

  8. High-Dose Statin Pretreatment Decreases Periprocedural Myocardial Infarction and Cardiovascular Events in Patients Undergoing Elective Percutaneous Coronary Intervention: A Meta-Analysis of Twenty-Four Randomized Controlled Trials

    Science.gov (United States)

    Wang, Le; Peng, Pingan; Zhang, Ou; Xu, Xiaohan; Yang, Shiwei; Zhao, Yingxin; Zhou, Yujie

    2014-01-01

    Background Evidence suggests that high-dose statin pretreatment may reduce the risk of periprocedural myocardial infarction (PMI) and major adverse cardiac events (MACE) for certain patients; however, previous analyses have not considered patients with a history of statin maintenance treatment. In this meta-analysis of randomized controlled trials (RCTs), we reevaluated the efficacy of short-term high-dose statin pretreatment to prevent PMI and MACE in an expanded set of patients undergoing elective percutaneous coronary intervention. Methods We searched the PubMed/Medline database for RCTs that compared high-dose statin pretreatment with no statin or low-dose statin pretreatment as a prevention of PMI and MACE. We evaluated the incidence of PMI and MACE, including death, spontaneous myocardial infarction, and target vessel revascularization at the longest follow-up for each study for subgroups stratified by disease classification and prior low-dose statin treatment. Results Twenty-four RCTs with a total of 5,526 patients were identified. High-dose statin pretreatment was associated with 59% relative reduction in PMI (odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.34–0.49; Pstatin pretreatment on MACE was significant for statin-naive patients (OR: 0.69; 95% CI: 0.50–0.95; P = 0.02) and prior low dose statin-treated patients (OR: 0.28; 95% CI: 0.12–0.65; P = 0.003); and for patients with acute coronary syndrome (OR: 0.52; 95% CI: 0.34–0.79; P = 0.003), but not for patients with stable angina (OR: 0.71; 95% CI 0.45–1.10; P = 0.12). Long-term effects on survival were less obvious. Conclusions High-dose statin pretreatment can result in a significant reduction in PMI and MACE for patients undergoing elective PCI. The positive effect of high-dose statin pretreatment on PMI and MACE is significant for statin-naïve patients and patients with prior treatment. The positive effect of high-dose statin pretreatment on MACE is significant for

  9. Mistura de biodiesel de sebo bovino em motor diesel durante 600 horas Blend of biodiesel from beef tallow in a diesel engine during 600 hours of tests

    Directory of Open Access Journals (Sweden)

    Ila Maria Corrêa

    2011-07-01

    Full Text Available O biodiesel de sebo bovino é considerado uma alternativa de baixo custo e de grande disponibilidade por ser resíduo da produção agropecuária brasileira, que é uma das maiores do mundo. Raros são os trabalhos que mostram a utilização do biodiesel de sebo bovino em motores diesel. Assim, o objetivo deste trabalho foi verificar o efeito da mistura de biodiesel bovino na proporção de 5% ao óleo diesel comercial no desempenho do motor, possíveis consequências internas no motor e nas características do óleo lubrificante após o uso prolongado em motor diesel. Foram realizados ensaios em bancada dinamométrica utilizando um trator agrícola. O desempenho do motor foi determinado através da tomada de potência (TDP. O motor foi operado por 600h durante as quais foi determinada a potência, o consumo de combustível e analisadas as amostras de óleo lubrificante a cada 100h. Ao final do ensaio, o motor foi aberto e inspecionado. A análise do óleo lubrificante mostrou nível de contaminação crítico a partir das 400h, mas a inspeção visual do motor não detectou nenhum desgaste interno. O motor funcionou normalmente, embora tenha ocorrido tendência de redução na potência e aumento de consumo de combustível ao longo das 600h.Biodiesel from beef tallow has been considered a low-cost and high availability alternative due to be residue from the Brazilian livestock production, one of the world's largest. Papers that show the use of biodiesel from beef tallow in diesel engine are rare. The aim of this study was to investigate the effect of blend of biodiesel from beef tallow (B5 in commercial diesel oil on engine performance, analyzing possible internal consequences and characteristics of lubricating oil after the prolonged use in a diesel engine. Engine performance was evaluated through tractor power take off (PTO tests. The engine was operated for 600 hours. Power and fuel consumption were measured. Samples of lubricating oil were

  10. Surface Weather Observations Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Standard hourly observations taken at Weather Bureau/National Weather Service offices and airports throughout the United States. Hourly observations began during the...

  11. FEWER HOURS MORE ACHIEVEMENTS

    Institute of Scientific and Technical Information of China (English)

    NingQuanxin; QiuLizhong

    2004-01-01

    The goal of this study is to improve instructional classes for “Extensive Reading”. We compare two approaches. The traditional method is based on the original procedure; the method we try is a “task-placemented” one. inspired by the method we try is a “task-placemented” one. inspired by the theory of “Tasks of Ascending Difficulty”.This paper provides a comparative evaluation of our experiments on Extensive Reading. Our aim is to resolve the logistical problem of heavy teaching loads and limited class hours, which often prevents English learners from fulfilling their study targets and our intended learning outcomes. In view of the experimental data,we have managed to establish a “feedback” to test the two hypotheses, and demonstrate that the new approach contributes to efficient acquisition of the information in the presented reading materials. Our study concludes with an interpretation of the function and merits of this approach.

  12. [Comparison of efficacy between the serum cortisol and 24 hour urine free cortisol in combined dexamethasone suppression test in the diagnosis of Cushing syndrome].

    Science.gov (United States)

    Lu, L; Chen, J H; Zhu, H J; Song, A L; Li, M; Chen, S; Pan, H; Gong, F Y; Wang, R Z; Xing, B; Yao, Y; Feng, M; Lu, Z L

    2016-07-19

    To compare the sensitivity and specificity between the 24 hour urine free cortisol (24 h UFC) and serum cortisol in dexamethasone suppression test (DST) in the diagnosis of Cushing syndrome (CS). Combined low dose DST (LDDST) and high dose DST (HDDST) were carried out in 67 cases of CS with surgically confirmed cases in recent 3 years(from January 2011 to November 2015). The serum cortisol and 24 h UFC were collected simultaneously for each subject and the sensitivity and specificity of serum cortisol and 24 h UFC were compared. There were Cushing disease (CD) group (n=53), ectopic adrenocorticotropic hormone (ACTH) syndrome group (n=7) and ACTH-independent Cushing syndrome group (n=7) according to the etiology of hypercorticordism.There were no significant differences among 3 groups in gender and age.The sensitivity of serum cortisol of different cut off points(50, 110, 140 nmol/L and 50% of control)after LDDST was 97.01%, 86.57%, 83.58% and 70.15% respectively.Meanwhile, the sensitivity of cutoff point of 24 h UFC Cushing syndrome.There was no significant differences in two groups between serum cortisol Cushing disease was 60.38% and 90.57%, and the specificity was 91.43% and 96.00% respectively.There were significant differences between serum cortisol and 24 h UFC in both of sensitivity and specificity (both P<0.05). In addition, if the suppression rate of 24 h UFC in HDDST was adjusted to 60.85% according to receiver operating characteristic (ROC) curve, it could have the best levels of sensitivity (92.6%) with the specificity of 85.7%. If the suppression rate of serum cortisol was adjusted to 61.53% in HDDST according to ROC curve, it could have the best sensitivity (64.8%) with the specificity of 78.6% accordingly. In combined LDDST, the serum cortisol <50 nmol/L had a higher sensitivity than the 24 h UFC<32 nmol when they were used as the criteria in determining the diagnosis of CS.In HDDST, the sensitivity and specificity of suppression rate of 24 h UFC

  13. Association between symptoms and frequency of arrhythmias on 24-hour Holter monitoring.

    Science.gov (United States)

    Irfan, Ghazala; Ahmad, Mansoor; Khan, Abdul Rasheed

    2009-11-01

    To determine association between patient's symptoms and incidence of arrhythmia on 24-hour electrocardiographic Holter monitoring. A cross-sectional descriptive study. The Cardiology Department, Liaquat National Hospital, Karachi, from January to June 2007. Patients above 15 years of age, of either gender, referred for Holter monitoring with symptoms of palpitations, dizziness and syncope were evaluated for arrhythmia. The symptoms were documented by the patients in their symptom diaries (historical logs) during Holter monitoring. Patients who had permanent pacemaker implants were excluded. Descriptive statistics were used to calculate the frequencies and percentages of different symptoms, different arrhythmias were noted on Holter monitoring and the age of patients was noted. Chi-square test was applied to calculate p-values with significant at value less than 0.05. The mean age of patients was 53.71 +/- 15.52 years. There were 54% females and 46% males. Eighty two percent had documented arrhythmias on their Holter monitoring reports. The complaints for which patients were referred included dizziness in 24%, palpitations in 61% and syncope in 15%. On analysis of the historical logs of patients only 64% had symptoms during Holter monitoring and 23% had concurrence of their symptoms with an arrhythmia. Patients who had sinus exit block (p=0.02) and sinus arrest (p=0.002) had significant association with arrhythmia. Twenty percent patients with dizziness, 50% patients with palpitations and 12% of patients who presented with syncope had documented arrhythmias. Twenty four hour Holter monitoring is an important investigation for evaluation of patients with palpitation, dizziness and syncope. Arrhythmias were detected frequently in both symptomatic and asymptomatic patients. One must be careful to avoid attributing a symptom to an arrhythmia until a close temporal relationship is demonstrated.

  14. Evaluation program for secondary spacecraft cells: Initial evaluation tests of General Electric Company 40.0 ampere-hour nickel-cadmium spacecraft cells for the tracking data relay satellite system

    Science.gov (United States)

    Harkness, J. D.

    1978-01-01

    Five cells provided by NASA's Goddard Space Flight Center were evaluated at room temperature and pressure (25 C plus or minus 2 C) with discharges at the 2 hour rate. Measurements of the cell containers following test, indicated an average increase of .006 inches at the plate thickness. Average end of charge voltages and pressures, and capacity output in ampere hours were determined. Three cells exceeded the voltage requirements of 1.52 volts during both c/10 charges at 20 C. All cells exceeded the voltage requirement of 1.52 volts during the 0 C overcharge test, although their end charges were below 1.50 volts. The pressure requirement of 65 psia was exceeded by both pressure transducer cells during c/10 charges at 25 C and 20 C and also during the 0 C overcharge test. The cells with pressure transducers reached a pressure of 20 psia before reaching the voltage limit of 1.550 volts during the pressure versus capacity test, and exhibited a pressure decay of 2 psia during the last 30 minutes of the 1 hour open circuit stand. Average capacity was 51.3 ampere hours.

  15. Sensibilidade gustativa ao sal, natriúria e pressão arterial em indivíduos normotensos Salt taste threshold, 24 hour natriuresis and blood pressure variation in normotensive individuals

    Directory of Open Access Journals (Sweden)

    Vicente Sperb Antonello

    2007-04-01

    Full Text Available OBJETIVO: O estudo avalia sensibilidade gustativa ao sal, excreção urinária de sódio e pressão arterial (PA em normotensos. A hipótese foi de que limiar de sensibilidade gustativa ao sal (LSGS aumentado se associasse a maior natriúria em 24 horas e níveis aumentados de PA. MÉTODOS: Foram avaliados 24 voluntários sem diagnóstico de HA. Para avaliar LSGS, usou-se soluções de cloreto de sódio (NaCl em diferentes concentrações. Os voluntários foram submetidos à monitorização ambulatorial da pressão arterial (MAPA de 24 horas e coleta de urina de 24 horas para dosagem de sódio (NaU. Para análise, foram agrupados de acordo com o LSGS, aumentado ou normal. RESULTADOS: Os grupos não diferiram para idade, índice de massa corporal (IMC, variáveis demográficas, uso de álcool, fumo e PA. NaU foi significativamente maior no grupo com LSGS aumentado. Utilizando-se o coeficiente de correlação de Pearson, com significância determinada pelo teste t, houve correlação de forte intensidade entre médias de PA sistólica e diastólica com IMC, de regular intensidade entre LSGS e NaU, assim como para PA sistólica e NaU. CONCLUSÃO: Natriúria de 24 horas foi maior em indivíduos com LSGS aumentado, sugerindo que esta maior avidez ao sal determine maior ingestão de sódio. Houve forte associação entre PA e IMC. Não foi evidenciada associação entre LSGS e PA, diferente do já documentado em pacientes com PA aumentada. Aumentando-se o número de pessoas, faixa etária e pacientes com níveis pressóricos aumentados, talvez se respondam outras perguntas a respeito da relação entre LSGS, natriúria e PA.OBJECTIVE: The study evaluates salt taste sensibility, urinary sodium excretion and blood pressure (BP in normotensive persons. The hypothesis was that a higher salt taste threshold (STT can be associated to a higher 24 hour natriuresis and increased BP levels. METHODS: Twenty four not hypertensive volunteers were selected. To

  16. Evaluation program for secondary spacecraft cells: Initial evaluation tests of General Electric Company 40.0 ampere hour nickel cadmium spacecraft cells for the tracking data relay satellite system

    Science.gov (United States)

    Hall, S. W.

    1980-01-01

    Average end of charge voltages and pressures, and capacity output in ampere hours are presented. Test limits specify those values at which a cell is to be terminated from charge or discharge. Requirements are based on past cell performance data. The requirement does not constitute a limit for discontinuance from testing. The nickel cadmium batteries were screened for internal shorts, low capacity, electrolyte leakage, or inability of any cell to recover its open circuit voltage above 1.150 volts during the internal short test.

  17. Twenty-Four Tuba Harmonics Using a Single Pipe Length

    Science.gov (United States)

    Holmes, Bud; Ruiz, Michael J.

    2017-01-01

    Harmonics arise naturally from the resonances in strings and pipes. A video demonstration (Ruiz 2016 "YouTube: Tuba Harmonics" (https://youtu.be/souhEzOP9c4)) is provided where a tubist (coauthor Holmes) produces a phenomenal 24 harmonics using a single tuba pipe length by controlling the buzz of his lips. The frequencies of the…

  18. Twenty-four tuba harmonics using a single pipe length

    Science.gov (United States)

    Holmes, Bud; Ruiz, Michael J.

    2017-03-01

    Harmonics arise naturally from the resonances in strings and pipes. A video demonstration (Ruiz 2016 YouTube: Tuba Harmonics (https://youtu.be/souhEzOP9c4)) is provided where a tubist (coauthor Holmes) produces a phenomenal 24 harmonics using a single tuba pipe length by controlling the buzz of his lips. The frequencies of the harmonics, measured with the free software program Audacity, fall excellently on a linear fit using a spreadsheet. The skillful musical production of so many harmonics with a fixed pipe length is an extraordinary illustration of physics.

  19. The Effect of a Two-Hour, Room Temperature Incubation of Human Spermatozoa in TEST-Yolk Buffer on the Rate of Fertilization in Vitro

    OpenAIRE

    Jensen, Julie R.; Walker, John H.; Milki, Amin A.; Westphal, Lynn; Behr, Barry

    2004-01-01

    Patients: To reassess the use of TEST-yolk buffer (TYB) in an in vitro fertilization (IVF) program by comparing fertilization rates achieved in a glucose-free cleavage medium by the standard IVF preparation of sperm versus a 2-h, room temperature incubation of sperm in TYB.

  20. New gate opening hours

    CERN Multimedia

    GS Department

    2009-01-01

    Please note the new opening hours of the gates as well as the intersites tunnel from the 19 May 2009: GATE A 7h - 19h GATE B 24h/24 GATE C 7h - 9h\t17h - 19h GATE D 8h - 12h\t13h - 16h GATE E 7h - 9h\t17h - 19h Prévessin 24h/24 The intersites tunnel will be opened from 7h30 to 18h non stop. GS-SEM Group Infrastructure and General Services Department

  1. Eleventh Hour Security+

    CERN Document Server

    Dubrawsky, Ido

    2009-01-01

    This book will focus on just the essentials needed to pass the Security+ certification exam. It will be filled with critical information in a way that will be easy to remember and use for your quickly approaching exam. It will focus on the main objectives of the exam and include the following pedagogy for ease of use in those final hours. The book will include:. •Exam Objectives – Fast Track Review. •Key words/definitions. •Five Toughest questions and their answers. •Exam Warnings – What to pay attention to

  2. Eleventh Hour Linux+

    CERN Document Server

    Speake, Graham; Happel, Chris; Lillard, Terrence V

    2009-01-01

    The 11th Hour Linux+ Study Guide is keyed to the XK0-003 revision of the CompTIA Linux+exam. This book is streamlined to include only core certification information and is presented for ease of last-minute studying. Main objectives of the exam are covered with key concepts highlighted. ..: ..; Fast Facts quickly review fundamentals ..; Exam Warnings highlight particularly tough sections of the exam ..; Crunch Time sidebars point out key concepts to remember ..; Did You Know? sidebars cover sometimes forgotten details ..; Top Five Toughest Questions and answers help you to prepare .. The 11th H

  3. The context counts: congruent learning and testing environments prevent memory retrieval impairment following stress.

    Science.gov (United States)

    Schwabe, Lars; Wolf, Oliver T

    2009-09-01

    Stress before retention testing impairs memory, whereas memory performance is enhanced when the learning context is reinstated at retrieval. In the present study, we examined whether the negative impact of stress before memory retrieval can be attenuated when memory is tested in the same environmental context as that in which learning took place. Subjects learned a 2-D object location task in a room scented with vanilla. Twenty-four hours later, they were exposed to stress or a control condition before memory for the object location task was assessed in a cued-recall test, either in the learning context or in a different context (unfamiliar room without the odor). Stress impaired memory when assessed in the unfamiliar context, but not when assessed in the learning context. These results suggest that the detrimental effects of stress on memory retrieval can be abolished when a distinct learning context is reinstated at test.

  4. Development and Pilot Testing of 24-Hour Multiple-Pass Recall to Assess Dietary Intake of Toddlers of Somali- and Iraqi-Born Mothers Living in Norway

    Directory of Open Access Journals (Sweden)

    Navnit Kaur Grewal

    2014-06-01

    Full Text Available The aim of this study was to develop, test, and evaluate a 24-h recall procedure to assess the dietary intake of toddlers of Somali- and Iraqi-born mothers living in Norway. A protocol for a 24-h multiple-pass recall procedure, registration forms, and visual tools (a picture library for food identification and portion size estimation was developed and tested in 12 mothers from Somalia and Iraq with children aged 10–21 months. Five female field workers were recruited and trained to conduct the interviews. Evaluation data for the 24-h recall procedure were collected from both the mothers and the field workers. Nutrient intake was calculated using a Norwegian dietary calculation system. Each child’s estimated energy intake was compared with its estimated energy requirement. Both the mothers and the field workers found the method feasible and the visual tools useful. The estimated energy intake corresponded well with the estimated energy requirement for most of the children (within mean ± 2 SD, except for three. The pilot study identified the need for additional foods in the picture library and some crucial aspects in training and supervising the field workers to reduce sources of error in the data collection.

  5. Gas turbine and advanced HTGR materials screening test program: 10,000-hour results and semiannual progress report for the period ending March 31, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Rosenwasser, S.N.; Johnson, W.R.

    1977-07-01

    Work on the Gas-Turbine and Advanced High-Temperature Gas-Cooled Reactor (HTGR) Materials Screening Test Program is documented. Emphasis is on the results and analyses of creep data to 11,000 hr and the detailed metallurgical evaluations performed on candidate alloy specimens tested for up to 10,000 hr. Long-term creep and unstressed aging data in controlled-impurity helium and in air at 650, 800, and 900/sup 0/C are reported for the original alloys in the program, including the vacuum-cast Ni-base superalloys, IN 100, Rene 100, IN 713, MM 004, M 21, and IN 738; the wrought solid-solution-strengthened Ni--Cr alloys, Hastelloy X and Inconel 617; the centrifugally-cast austenitic Fe--Ni--Cr alloy, IN 519; the oxide-dispersion-strengthened (ODS) Ni--Cr alloys, MA 753 and MA 754; and the wrought Mo-base alloy, MoTZM. Results at 650/sup 0/C and 10,000 hr for the precipitation-strengthened alloys Inconel 718, Inconel 706, and A 286 are also included. Similar, but much shorter term data at 800, 900, and 1000/sup 0/C for the recently added wrought alloys Hastelloy X (second heat), Hastelloy S, RA 333, and HD 556, and the additional centrifugally-cast alloys HK 40, Supertherm, Manaurite 36X, Manaurige 36XS, and Manaurite 900, are also reported.

  6. Geneva 24 hours swim

    CERN Document Server

    2003-01-01

    The 18th edition of the Geneva 24 hours swim competition will take place at the Vernets Swimming Pool on the 4th and 5th of October. More information and the results of previous years are given at: http://www.carouge-natation.com/24_heures/home_24_heures.htm Last year, CERN obtained first position in the inter-company category with a total of 152.3 kms swam by 45 participants. We are counting on your support to repeat this excellent performance this year. For those who would like to train, the Livron swimming pool in Meyrin is open as from Monday the 8th September. For further information please do not hesitate to contact us. Gino de Bilio and Catherine Delamare

  7. Geneva 24 Hours Swim

    CERN Multimedia

    2003-01-01

    The 18th edition of the Geneva 24 hours swim competition will take place at the Vernets Swimming Pool on the 4th and 5th of October. More information and the results of previous years are given at: http://www.carouge-natation.com/24_heures/home_24_heures.htm Last year, CERN obtained first position in the inter-company category with a total of 152.3 kms swam by 45 participants. We are counting on your support to repeat this excellent performance this year. For those who would like to train, the Livron swimming pool in Meyrin is open as from Monday the 8th September. For further information please do not hesitate to contact us. Gino de Bilio and Catherine Delamare

  8. ST-segment deviation during 24-hour ambulatory electrocardiographic monitoring and exercise stress test in healthy male subjects 51 to 75 years of age: the Copenhagen City Heart Study

    DEFF Research Database (Denmark)

    Vaage-Nilsen, M; Rasmussen, Verner; Sørum, C

    1999-01-01

    BACKGROUND: Although ST-segment deviation has been evaluated and used during many years both on continuous electrocardiographic Holter monitoring and during exercise stress testing, considerable controversy still remains concerning the prevalence and diagnostic significance of fortuitously...... discovered ST-segment deviation in asymptomatic healthy persons. METHODS AND RESULTS: The occurrence of ST-segment deviation was studied in a population of 63 clinically healthy male subjects 51 to 75 years of age, with the use of 24-hour Holter monitoring and exercise stress testing. The subjects were......-segment deviation during Holter monitoring and exercise stress testing, indicated with a specificity of 1.0 or 0.95 according to choice of criterion, implies that the person is in a healthy state....

  9. ST-segment deviation during 24-hour ambulatory electrocardiographic monitoring and exercise stress test in healthy male subjects 51 to 75 years of age: the Copenhagen City Heart Study

    DEFF Research Database (Denmark)

    Vaage-Nilsen, M; Rasmussen, Verner; Sørum, C

    1999-01-01

    or descending ST-segment depression of >/=0.15 mV during Holter monitoring or at the exercise test, respectively. Furthermore, the specificity was 0.95 when a horizontal or downsloping ST-segment depression of 0.1 mV was displayed in both the Holter and exercise electrocardiographic recording system......BACKGROUND: Although ST-segment deviation has been evaluated and used during many years both on continuous electrocardiographic Holter monitoring and during exercise stress testing, considerable controversy still remains concerning the prevalence and diagnostic significance of fortuitously...... discovered ST-segment deviation in asymptomatic healthy persons. METHODS AND RESULTS: The occurrence of ST-segment deviation was studied in a population of 63 clinically healthy male subjects 51 to 75 years of age, with the use of 24-hour Holter monitoring and exercise stress testing. The subjects were...

  10. Determination of Functional Capabilities, the Level of Physical Performance and the State of Main Physiological Body Systems in the First Hours after the Accomplishment of Long-term Space Flights ("Field Test")

    Science.gov (United States)

    Kozlovskaya, Inesa; Tomilovskaya, Elena; Rukavishnikov, Ilya; Kitov, Vladimir; Reschke, Millard; Kofman, Igor

    2014-01-01

    Long-term stay in weightlessness is accompanied by alterations in the activity of main physiological body systems including sensory-motor, skeletal-muscular disturbances and cardiovascular deconditioning. However, up to now, there are no data on the state and level of functional performance of cosmonauts/astronauts directly after flight, nor are there data to help define the dynamic recovery of functional characteristics and work efficiency which are greatly needed to provide the safety and planning of their activity once they reach space objects. The Russian and American scientists are currently engaged in a joint experiment known as the "Field Test" with the goal of studying the functional performance and the state of main physiological body systems directly after landing and their temporal recovery dynamics. The functional performance is identified during the test by temporal characteristics of the movements of spatial translation, the stability of the vertical stance for 3.5 min, and the kinematic characteristics of walking - non-complicated and complicated. The following characteristics are identified as physiological characteristics of the test: a) orthostatic tolerance during stand test, b) back muscle tone; c) vertical stability - by characteristics of the correction responses to unexpected perturbations of the vertical stance, and d) support reactions during the performance of the full battery of tests. To date, a pilot version of the "Field Test" has been conducted with participation from four Russian cosmonauts. The results of studies have shown that in 1 - 5 hours after landing the functional abilities of the cosmonauts are considerably reduced. All the test movements at this time are considerably slower than preflight and the more complicated the task is, the greater significant reduction in orthostatic tolerance: during the first test that occurs 1 - 5 hours after landing. two of four cosmonauts declined to continue the task after the orthostatic test

  11. Comparisons of Office and 24-Hour Ambulatory Blood Pressure Monitoring in Children with Obstructive Sleep Apnea.

    Science.gov (United States)

    Kang, Kun-Tai; Chiu, Shuenn-Nan; Weng, Wen-Chin; Lee, Pei-Lin; Hsu, Wei-Chung

    2017-03-01

    To compare office blood pressure (BP) and 24-hour ambulatory BP (ABP) monitoring to facilitate the diagnosis and management of hypertension in children with obstructive sleep apnea (OSA). Children aged 4-16 years with OSA-related symptoms were recruited from a tertiary referral medical center. All children underwent overnight polysomnography, office BP, and 24-hour ABP studies. Multiple linear regression analyses were applied to elucidate the association between the apnea-hypopnea index and BP. Correlation and consistency between office BP and 24-hour ABP were measured by Pearson correlation, intraclass correlation, and Bland-Altman analyses. In the 163 children enrolled (mean age, 8.2 ± 3.3 years; 67% male). The prevalence of systolic hypertension at night was significantly higher in children with moderate-to-severe OSA than in those with primary snoring (44.9% vs 16.1%, P = .006). Pearson correlation and intraclass correlation analyses revealed associations between office BP and 24-hour BP, and Bland-Altman analysis indicated an agreement between office and 24-hour BP measurements. However, multiple linear regression analyses demonstrated that 24-hour BP (nighttime systolic BP and mean arterial pressure), unlike office BP, was independently associated with the apnea-hypopnea index, after adjustment for adiposity variables. Twenty-four-hour ABP is more strongly correlated with OSA in children, compared with office BP. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. ST-segment deviation during 24-hour ambulatory electrocardiographic monitoring and exercise stress test in healthy male subjects 51 to 75 years of age: the Copenhagen City Heart Study

    DEFF Research Database (Denmark)

    Vaage-Nilsen, M; Rasmussen, Verner; Sørum, C

    1999-01-01

    BACKGROUND: Although ST-segment deviation has been evaluated and used during many years both on continuous electrocardiographic Holter monitoring and during exercise stress testing, considerable controversy still remains concerning the prevalence and diagnostic significance of fortuitously...... discovered ST-segment deviation in asymptomatic healthy persons. METHODS AND RESULTS: The occurrence of ST-segment deviation was studied in a population of 63 clinically healthy male subjects 51 to 75 years of age, with the use of 24-hour Holter monitoring and exercise stress testing. The subjects were...... in healthy subjects without disease, was 1.0 when using as criterion for significant ST-segment deviation a horizontal or descending ST-segment depression of >0.20 mV or ST-segment elevation >/=0.15 mV during Holter monitoring, and acceptable, for example, 0.95, when using as criterion a horizontal...

  13. Hourly Precipitation Data (HPD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hourly Precipitation Data (HPD) Publication is archived and available from the National Climatic Data Center (NCDC). This publication contains hourly precipitation...

  14. US Naval Observatory Hourly Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hourly observations journal from the National Observatory in Washington DC. The observatory is the first station in the United States to produce hourly observations...

  15. QT variability index on 24-hour Holter independently predicts mortality in patients with heart failure: analysis of Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca (GISSI-HF) trial.

    Science.gov (United States)

    Dobson, Craig P; La Rovere, Maria Teresa; Pinna, Gian Domenico; Goldstein, Robert; Olsen, Cara; Bernardinangeli, Marino; Veniani, Marco; Midi, Paolo; Tavazzi, Luigi; Haigney, Mark

    2011-08-01

    Increased temporal variability of repolarization, as reflected by QT interval variability measured over 10-15 minutes, predicted spontaneous ventricular arrhythmias and death in implantable cardioverter-defibrillator patients in mild to moderate heart failure (HF). The purpose of this study was to test our hypothesis that increased mean QT variability over 24 hours would be associated with increased cardiovascular (CV) mortality in a heterogeneous HF population. The Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure trial prospectively enrolled subjects with HF of any cause. Twenty-four-hour Holter recordings from 268 subjects were analyzed using a template-matching, semiautomatic algorithm to measure QT and heart rate time series in sequential 5-minute epochs over 24 hours. The QT variability index (QTVI) was expressed as the log ratio of the normalized QT variance over normalized heart rate variance. Total and CV mortality were assessed as a function of continuous and dichotomous QTVI (>-0.84) in univariate and multivariable Cox proportional hazards models, adjusting for significant clinical predictors. After a median of 47 months, there were 53 deaths, of which 44 were from CV causes. A significant association with the outcome was found for QTVI both as continuous and dichotomous variables after adjustment for clinical covariates (age >70, New York Heart Association class III-IV, left ventricular ejection fraction, nonsustained ventricular tachycardia, creatinine): QTVI hazard ratio (HR) 4.0 (confidence interval [CI] 1.8-88; P = .008) for total and 4.4 (CI 1.9-10.1; P = .0006) for CV mortality; QTVI >-0.84 HR 2.0 (CI 1.1-3.6; P = .02) for total and 2.1 (CI 1.1-3.8; P = .02) for CV mortality. Increased repolarization lability, as reflected in QTVI measured over 24 hours, is associated with increased risk for total and CV mortality in a heterogeneous population with chronic HF. Published by Elsevier Inc.

  16. Comparison of the broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing with the 24-hour CLSI BMD method for testing susceptibility of Candida species to fluconazole, posaconazole, and voriconazole by use of epidemiological cutoff values.

    Science.gov (United States)

    Pfaller, M A; Espinel-Ingroff, A; Boyken, L; Hollis, R J; Kroeger, J; Messer, S A; Tendolkar, S; Diekema, D J

    2011-03-01

    The antifungal broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) was compared with CLSI BMD method M27-A3 for fluconazole, posaconazole, and voriconazole susceptibility testing of 1,056 isolates of Candida. The isolates were obtained in 2009 from more than 60 centers worldwide and included 560 isolates of C. albicans, 175 of C. glabrata, 162 of C. parapsilosis, 124 of C. tropicalis, and 35 of C. krusei. The overall essential agreement (EA) between EUCAST and CLSI results ranged from 96.9% (voriconazole) to 98.6% (fluconazole). The categorical agreement (CA) between methods and species of Candida was assessed using previously determined epidemiological cutoff values (ECVs). The ECVs (expressed as μg/ml) for fluconazole, posaconazole, and voriconazole, respectively, were as follows: 0.12, 0.06, and 0.03 for C. albicans; 32, 2, and 0.5 for C. glabrata; 2, 0.25, and 0.12 for C. parapsilosis; 2, 0.12, and 0.06 for C. tropicalis; 64, 0.5, and 0.5 for C. krusei. Excellent CA was observed for all comparisons between the EUCAST and CLSI results for fluconazole, posaconazole, and voriconazole, respectively, for each species: 98.9%, 93.6%, and 98.6% for C. albicans; 96.0%, 98.9%, and 93.7% for C. glabrata; 90.8%, 98.1%, and 98.1% for C. parapsilosis; 99.2%, 99.2%, and 96.8% for C. tropicalis; 97.1%, 97.1%, and 97.1% for C. krusei. We demonstrate high levels of EA and CA between the CLSI and EUCAST BMD methods for testing of triazoles against Candida when the MICs were determined after 24 h and ECVs were used to differentiate wild-type (WT) from non-WT strains. These results provide additional data in favor of the harmonization of these two methods.

  17. Comparison of the Broth Microdilution (BMD) Method of the European Committee on Antimicrobial Susceptibility Testing with the 24-Hour CLSI BMD Method for Testing Susceptibility of Candida Species to Fluconazole, Posaconazole, and Voriconazole by Use of Epidemiological Cutoff Values▿

    Science.gov (United States)

    Pfaller, M. A.; Espinel-Ingroff, A.; Boyken, L.; Hollis, R. J.; Kroeger, J.; Messer, S. A.; Tendolkar, S.; Diekema, D. J.

    2011-01-01

    The antifungal broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) was compared with CLSI BMD method M27-A3 for fluconazole, posaconazole, and voriconazole susceptibility testing of 1,056 isolates of Candida. The isolates were obtained in 2009 from more than 60 centers worldwide and included 560 isolates of C. albicans, 175 of C. glabrata, 162 of C. parapsilosis, 124 of C. tropicalis, and 35 of C. krusei. The overall essential agreement (EA) between EUCAST and CLSI results ranged from 96.9% (voriconazole) to 98.6% (fluconazole). The categorical agreement (CA) between methods and species of Candida was assessed using previously determined epidemiological cutoff values (ECVs). The ECVs (expressed as μg/ml) for fluconazole, posaconazole, and voriconazole, respectively, were as follows: 0.12, 0.06, and 0.03 for C. albicans; 32, 2, and 0.5 for C. glabrata; 2, 0.25, and 0.12 for C. parapsilosis; 2, 0.12, and 0.06 for C. tropicalis; 64, 0.5, and 0.5 for C. krusei. Excellent CA was observed for all comparisons between the EUCAST and CLSI results for fluconazole, posaconazole, and voriconazole, respectively, for each species: 98.9%, 93.6%, and 98.6% for C. albicans; 96.0%, 98.9%, and 93.7% for C. glabrata; 90.8%, 98.1%, and 98.1% for C. parapsilosis; 99.2%, 99.2%, and 96.8% for C. tropicalis; 97.1%, 97.1%, and 97.1% for C. krusei. We demonstrate high levels of EA and CA between the CLSI and EUCAST BMD methods for testing of triazoles against Candida when the MICs were determined after 24 h and ECVs were used to differentiate wild-type (WT) from non-WT strains. These results provide additional data in favor of the harmonization of these two methods. PMID:21227994

  18. Automatization of physicians' phone-in hours.

    Science.gov (United States)

    Turunen, J; Loula, P; Soininen, H

    1999-01-01

    In this paper we present a computer-based system that is designed to reduce the number of patient calls in physicians' phone-in hours. Simultaneously it will offer a parallel alternative channel for the patients to listen to their laboratory results. The system requirements were reliability, security and the low costs. The results showed after a two-month test period that the tailored system proved extremely successful. The average time that the physician saved by using this system was over 4 minutes and doctors can leave the messages to the server also outside the phone-in hours.

  19. Evaluation of hydrotherapy, using passive tests and power tests, for recovery across a cyclic week of competitive rugby union.

    Science.gov (United States)

    Higgins, Trevor R; Climstein, Mike; Cameron, Melainie

    2013-04-01

    In team sports, a cycle of training, competition, and recovery occurs weekly during the competitive season. In this research, we evaluated hydrotherapy for recovery from a simulated game of rugby union tracked over a week of training. Twenty-four experienced male rugby union players (mean ± SD age 19.46 ± 0.82 years, weight 82.38 ± 11.12 kg, height 178.54 ± 5.75 cm) were randomly divided into 3 groups: cold water immersion (n = 8), contrast bath therapy (n = 8), and a control group (n = 8). The 2 forms of hydrotherapy were administered immediately after a simulated rugby game. Testing was conducted 1 hour before the game and at 5 intervals postgame: 1, 48, 72, 96, and 144 hours. Dependent variables included countermovement jump, 10- and 40-m sprints, sessional rating of perceived exertion (RPE), flexibility, thigh circumference, and self-reported delayed onset muscle soreness (DOMS). Significant differences in DOMS were found between the cold water immersion and contrast bath groups at 48 hours post intervention (p = 0.02), and between the control and contrast bath groups at 72 (p = 0.03) and 96 (p = 0.04) hours post intervention. Cold water immersion and contrast bath groups reported significantly different RPE at 72 hours (p = ?) and 96 hours post (p = 0.05) intervention. Athletes' perceptions of muscle soreness and sessional RPE scores for training were greater in the contrast bath group (20%) after the simulated game and throughout the training week. Although results from passive and power tests were inconclusive in determining whether cold water immersion or passive recovery was more effective in attenuating fatigue, results indicated contrast baths had little benefit in enhancing recovery during a cyclic week of rugby union.

  20. Ozone Nonattainment Areas - 1 Hour

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data layer identifies areas in the U.S. where air pollution levels have not met the National Ambient Air Quality Standards (NAAQS) for Ozone - 1hour (Legacy...

  1. Research Progress of 1-hour Hyperglycemia after Oral Glucose Tolerance Test%口服葡萄糖耐量试验后1h高血糖的研究进展

    Institute of Scientific and Technical Information of China (English)

    钟志标

    2012-01-01

    1 -hour hyperglycemia during oral glucose tolerance test is a transitional state of abnormal glucose regulation from normal glucose tolerance to type 2 diabetes mellitus. It is an independent risk factor for both type 2 diabetes mellitus and cardiovascular disease. Compared with normal glucose tolerance persons,they have a decreased (3 cell function and higher probability of the conversion to impaired glucose regulation or type 2 diabetes mellitus. Weight control,reasonable exercise and drugs such as biguanides can improve insulin pcell function, thus decrease serum glucose level.%口服葡萄糖耐量试验后1h高血糖是正常糖耐量过渡到2型糖尿病的异常糖代谢状态,它是2型糖尿病和心血管疾病的独立危险因素,与正常血糖人群相比,其胰岛β细胞功能已经降低,更容易发展成为葡萄糖调节受损或2型糖尿病的状态.控制体质量,适当的运动,服用双胍类均可改善胰岛β细胞功能,从而降低血糖水平.

  2. Ultimate treatment for a patient with severe traumatic brain injury without intake for 192 hours after Wenchuan massive earthquake

    Institute of Scientific and Technical Information of China (English)

    GU Jian-wen; ZHOU Hu-tian; YANG Tao; CHENG Jing-min; QU Yan; LI Cui-ying; LI Qing-jie; L(U) Ji-yun; CHENG Shou-long; LIU Jian-jun; KUANG Yong-qin; HUANG Hai-dong; YANG Li-bin; HE Wei-qi; ZHAO Kai; SONG Li-xin; ZHENG Xiao-dong; LIU Shu-xin; SUN Yan; HE Hong-lian; WU Jiang; LIU Xu-sheng; LU Min

    2009-01-01

    @@ At 14:28 (2:28 pm) on May 12, 2008, a magnitude 8 earthquake, which was a rare event, occurred in Sichuan Province of China and led to deaths of thousands of people. In the Longmen Mountain fault zone, which is located 40 miles from the earthquake center at Wenchuan, the Chinese military used a variety of treatment methods to rescue the injured and successfully treated a victim with severe traumatic brain injury (TBI) who survived without food or water intake for 192 hours. Two hundred and twenty-four hours after the earthquake, the patient underwent craniotomy and removal of an intracerebral hematoma. The injury to the patient was severe and the rescue time was the longest for this earthquake. Detailed information is provided in this report.

  3. 24-hour energy expenditure and substrate oxidation rates are unaffected by body fat distribution in obese women.

    Science.gov (United States)

    Buemann, B; Astrup, A; Quaade, F; Madsen, J

    1994-01-01

    Twenty-four-hour energy expenditure (EE) and nonprotein respiratory quotient (RQnp) were measured by indirect calorimetry in 19 upper-body-obese (UBO) and 15 lower-body-obese (LBO) women with similar body mass index (BMI) and body fat percent. The measurements were performed in a respiration chamber on a predetermined physical activity program and a controlled diet. No differences between the UBO and LBO groups were found in 24-hour, daytime, and sleeping EE after adjustment for differences in fat-free mass (FFM). Furthermore, no group effect was observed in RQnp, but a positive correlation was found between RQnp and age. Despite the fact that an increased free fatty acid (FFA) turnover has been found in UBO subjects, the present study does not support the contention that upper-body obesity is accompanied by an increased lipid oxidation.

  4. Excel VBA 24-hour trainer

    CERN Document Server

    Urtis, Tom

    2015-01-01

    Master VBA automation quickly and easily to get more out of Excel Excel VBA 24-Hour Trainer, 2nd Edition is the quick-start guide to getting more out of Excel, using Visual Basic for Applications. This unique book/video package has been updated with fifteen new advanced video lessons, providing a total of eleven hours of video training and 45 total lessons to teach you the basics and beyond. This self-paced tutorial explains Excel VBA from the ground up, demonstrating with each advancing lesson how you can increase your productivity. Clear, concise, step-by-step instructions are combined wit

  5. Air Temperature Variation and Mutation Analysis of the Twenty-Four Solar Terms in Xi'an over 60 Years%近60年西安市24节气气温变化特征及突变分析

    Institute of Scientific and Technical Information of China (English)

    沈姣姣; 徐虹; 李建科; 王靖; 高红燕; 杨新

    2013-01-01

    Based on daily air temperature from 1951-2010, mean air temperature (MAT) and the beginning-day air temperature (BAT), variation characteristics of the twenty-four solar terms in Xi'an were examined. MAT and BAT of phenological solar terms (Waking of Insects, Pure Brightness, Lesser Fullness of Grain and Grain in Beard) were used. We found that MAT of Lesser Heat and Greater Heat was higher than other solar terms, Lesser Cold was the coldest in all. Ending-day air temperature (EAT) was higher than BAT in each solar term from Greater Cold to Lesser Heat, and was lower than BAT in each solar term from Greater Heat to Lesser Cold. Curve of MAT variation of contiguous solar terms showed a single peak at Pure Brightness which was 3.4℃ higher than the Spring Equinox and single valley at the Beginning of Winter which was 3.9℃ lower than Frost's Descent. Daily MAT of seasonal solar terms varied as follows: spring (+0.190℃/ d) > autumn (-0.180℃/d) > winter (-0.105℃/d) > summer (+0.086℃/d). Daily MAT during the Beginning of Winter(-0.303℃/d), Waking of Insects (+0.233℃/d), Lesser Snow(-0.220℃/d) and Spring Equinox(+0.219℃/d) varied violently. MAT and BAT of most twenty-four solar terms showed a significant rising trend in the 1990s or 2000s, but BAT of autumn and winter solar terms did not change significantly in decadal temperature from 1951 to 2010. In 2000s, MAT of the Beginning of Spring, Greater Heat, the Beginning of Autumn, the End of Heat and the Winter Solstice dropped instead of rise. BAT and MAT of Waking of Insects rose in 1998 and 2008 at the 0.05 significant level, then in 2001 and 2010 at the 0.01 significant level. Pure Brightness and Lesser Fullness of Grain suddenly wanned in the 1990s (1999 and 1993), with 0.05 significant level at the beginning of 2000s (2004 and 2003) and 0.01 significant level in the mid-2000s (2006 and 2006). MAT and BAT of Grain in Beard showed a periodic rising and dropping trend, when it suddenly dropped at the

  6. Constructing gridded hourly temperature data sets

    Science.gov (United States)

    Dumitrescu, Alexandru

    2013-04-01

    Air temperature is the main climatological element, with major impact on the earth-atmosphere energy balance. The characteristics of the surface air temperature in locations without meteorological measurements are obtained using spatio-temporal interpolation techniques. Gridded surface meteorological data are essential for evaluating the performance of regional climate models (RCMs), for applying Statistical Downscaling (SD) methods and as input data for hydrological models. In this study we proposed a methodolgy for interpolating hourly surface temperatures. Three gridding methods are compared. A two-step multivariate gridding approach was used. First we interpolated the hourly normal maps, considered as multiannual average (1961-2010), of air temperature for each hour (4 meteorological terms) of a standard year (366 days). In this step, the Residual Kriging method was used with potential predictors derived from DEM and Landcover Corinne. For interpolating the residuals of the regression model we tested 3 gridding methods: Multiquadratic (MQ), Ordinary Kriging (OK) and 3D Kriging (using time as a third dimension). In the second step, we calculated the anomalies of each hour, day, year for the period 1961-2010. The anomalies were interpolated using the same methods applied for gridding regression residuals. The final hourly surface air temperature maps were obtained by summing the maps from first step with the anomlies map. The main data used in this work were the hourly air temperatures of the 4 observation terms (01, 07, 13, 19), measured between 1961-2010 at the weather stations of the Romanian Meteorological Administration. The predictors were derived from SRTM (Shuttle Radar Topography Mission) DEM and from CORINE Land Cover 2000 product. The gridding was performed in a Romanian National Grid (Stereo 70), at 1 km2 spatial resolution, using R language. The study has been financed by the research project Changes in climate extremes and associated impact in

  7. Hourly temporal distribution of wind

    Science.gov (United States)

    Deligiannis, Ilias; Dimitriadis, Panayiotis; Koutsoyiannis, Demetris

    2016-04-01

    The wind process is essential for hydrometeorology and additionally, is one of the basic renewable energy resources. Most stochastic forecast models are limited up to daily scales disregarding the hourly scale which is significant for renewable energy management. Here, we analyze hourly wind timeseries giving emphasis on the temporal distribution of wind within the day. We finally present a periodic model based on statistical as well as hydrometeorological reasoning that shows good agreement with data. Acknowledgement: This research is conducted within the frame of the undergraduate course "Stochastic Methods in Water Resources" of the National Technical University of Athens (NTUA). The School of Civil Engineering of NTUA provided moral support for the participation of the students in the Assembly.

  8. OPENING HOURS FOR CARDS OFFICE

    CERN Multimedia

    Human Resources Division

    2001-01-01

    Due to the extra workload generated by the global renewal of French cards and in order to preserve the level of service offered by the cards office, please note that this office will in future be open every morning from 8.30 a.m. to 12.30 p.m. until further notice. The service can be contacted by telephone during the same hours. Thank you for your understanding.

  9. Why the long hours? Job demands and social exchange dynamics.

    Science.gov (United States)

    Genin, Emilie; Haines, Victor Y; Pelletier, David; Rousseau, Vincent; Marchand, Alain

    2016-11-22

    This study investigates the determinants of long working hours from the perspectives of the demand-control model [Karasek, 1979] and social exchange theory [Blau, 1964; Goulder, 1960]. These two theoretical perspectives are tested to understand why individuals work longer (or shorter) hours. The hypotheses are tested with a representative sample of 1,604 employed Canadians. In line with Karasek's model, the results support that high job demands are positively associated with longer work hours. The social exchange perspective would predict a positive association between skill discretion and work hours. This hypothesis was supported for individuals with a higher education degree. Finally, the results support a positive association between active jobs and longer work hours. Our research suggests that job demands and social exchange dynamics need to be considered together in the explanation of longer (or shorter) work hours.

  10. 24 Hours of Meaty Torture

    Institute of Scientific and Technical Information of China (English)

    Palesa; Temaswati; Mthethwa

    2011-01-01

    VEGETARIAN for a week! That was the plan.But it’s funny how side effects start kicking in so early when trying to let go of an everyday habit.The first morning of my experiment,I felt like I hadn’t eaten poultry in months(I had devoured a bucket of KFC the night before).Lunch was a disaster.I didn’t know whether to cook or spend an hour searching for a restaurant. That afternoon I received the worst phone call a first-time vegetarian can get:

  11. HTML5 24-Hour Trainer

    CERN Document Server

    Lowery, Joseph W

    2011-01-01

    Comprehensive written and interactive instruction for learning HTML5 HTML is the core technology for building websites. Today, with HTML5 opening the Internet to new levels of rich content and dynamic interactivity, developers are looking for information to learn and utilize HTML5. HTML5 24-Hour Trainer provides that information, giving new and aspiring web developers the knowledge they need to achieve early success when building websites. Covers the most basic aspects of a web page, including a brief introduction to Cascading Style Sheets (CSS) Provides lessons that are backed up by prof

  12. Java programming 24-hour trainer

    CERN Document Server

    Fain, Yakov

    2015-01-01

    Quick and painless Java programming with expert multimedia instruction Java Programming 24-Hour Trainer, 2nd Edition is your complete beginner's guide to the Java programming language, with easy-to-follow lessons and supplemental exercises that help you get up and running quickly. Step-by-step instruction walks you through the basics of object-oriented programming, syntax, interfaces, and more, before building upon your skills to develop games, web apps, networks, and automations. This second edition has been updated to align with Java SE 8 and Java EE 7, and includes new information on GUI b

  13. 7 positions in 2 hours

    Directory of Open Access Journals (Sweden)

    Jessica Ackerman

    2013-07-01

    Full Text Available 7 positions in 2 hours (2013 is a drawing that documents the process of making the short film Role Reversal Rehearsal. It became quickly apparent that the process of making the work was more dynamic and interesting than the finished piece itself. Relationships between the childcare arrangements of the participants and the collective working process brought about the necessity of collaboration for parent artists. Each participant gave their time, energy and creative insight towards filming a series of birthing positions with roles reversed. The male performer became the central figure in an attempt to prompt empathy, humour, and to embody the importance of the male role in childbirth. There were two hours to choreograph, rehearse, and film the sequence. The drawing by Ackerman encapsulates the 'rhizomatic' approach to producing creative work under the constraints of parenthood. The 'arborescent' structure of hierarchy encouraged in industrial filmmaking is subsumed in favour of a horizontal structure. This new structure allows for the creative input, and flow of collaboration between all people involved - including the 3 and 5 year olds, who contributed ideas for camera and soundtrack in situ.

  14. Edwin Austin Abbey's The Passage of the Hours: Astronomy as History

    Science.gov (United States)

    Ricci, P. L.

    2016-01-01

    The Passage of the Hours (1909-1911) in the Pennsylvania State Capitol at Harrisburg is one of the most original and least known astronomical ceilings in the United States. Designed by the American artist Edwin Austin Abbey (1852-1911) to complement the Italian Renaissance style architecture of the House of Representatives, the mural combines two classical traditions of representing the night sky: a celestial map with the constellations of the zodiac and the personifications of the Hours. Set in a shallow dome twenty-four feet in diameter, Abbey's constellation figures float in a dazzling firmament where the Milky Way streams between the Sun and the Moon. The artist placed the Horae of Greek mythology around the dome's circumference in the position of the numbers on an astronomical clock. In the tradition of Italian Renaissance architecture, the celestial ceiling in the House of Representatives was part of an iconographic program affirming the cosmological origin of a polity. The astronomical theme relates to Abbey's murals in the House Chamber of the first public reading of the Declaration of Independence in 1776 from David Rittenhouse's observatory in Philadelphia, which the astronomer constructed to study the transit of Venus in 1769. The artist included a portrait of Rittenhouse holding his telescope among the worthies in the adjacent mural of The Apotheosis of Pennsylvania. Contemporary as well as historical events encouraged Abbey's use of astronomical imagery: the depiction of a comet may record the much-anticipated return of Halley's Comet in 1910.

  15. Short hours, long hours: Hour levels and trends in the retail industry in the United States, Canada, and Mexico

    OpenAIRE

    Carré, Françoise; Tilly, Chris

    2012-01-01

    In settings where most workers have full-time schedules, hourly wages are appropriate primary indicators of job quality and worker outcomes. However, in sectors where full-time schedules do not dominate - primarily service-producing activities - total hours matter, in addition to hourly wages, for job quality and worker outcomes. In this paper we employ a sector-focused, comparative framework to further examine hours levels - measured as average weekly hours - and trends in Canada, the United...

  16. Pilot Test of an Innovative Interprofessional Education Assessment Strategy

    Science.gov (United States)

    Emmert, Michelle Christine

    2011-01-01

    The primary goal of this study was to test an innovative way of assessing students' teamwork skills in a controlled environment. Twenty-four second year students from Western University of Health Sciences (WesternU) participated in the experimental group and 22 third year students from WesternU participated in the control group. Students in the…

  17. 24-Hour Relativistic Bit Commitment

    Science.gov (United States)

    Verbanis, Ephanielle; Martin, Anthony; Houlmann, Raphaël; Boso, Gianluca; Bussières, Félix; Zbinden, Hugo

    2016-09-01

    Bit commitment is a fundamental cryptographic primitive in which a party wishes to commit a secret bit to another party. Perfect security between mistrustful parties is unfortunately impossible to achieve through the asynchronous exchange of classical and quantum messages. Perfect security can nonetheless be achieved if each party splits into two agents exchanging classical information at times and locations satisfying strict relativistic constraints. A relativistic multiround protocol to achieve this was previously proposed and used to implement a 2-millisecond commitment time. Much longer durations were initially thought to be insecure, but recent theoretical progress showed that this is not so. In this Letter, we report on the implementation of a 24-hour bit commitment solely based on timed high-speed optical communication and fast data processing, with all agents located within the city of Geneva. This duration is more than 6 orders of magnitude longer than before, and we argue that it could be extended to one year and allow much more flexibility on the locations of the agents. Our implementation offers a practical and viable solution for use in applications such as digital signatures, secure voting and honesty-preserving auctions.

  18. Intracranial Pressure Elevation 24 Hours after Ischemic Stroke in Aged Rats is Prevented by Early, Short Hypothermia Treatment

    Directory of Open Access Journals (Sweden)

    Lucy Anne Murtha

    2016-05-01

    Full Text Available Stroke is predominantly a senescent disease, yet most preclinical studies investigate treatment in young animals. We recently demonstrated that short-duration hypothermia-treatment completely prevented the dramatic intracranial pressure (ICP rise seen post-stroke in young rats. Here, our aim was to investigate whether a similar ICP rise occurs in aged rats and to determine whether short-duration hypothermia is an effective treatment in aged animals. Experimental Middle Cerebral Artery occlusion (MCAo - 3 hour occlusion was performed on male Wistar rats aged 19-20 months. At one hour after stroke-onset, rats were randomized to 2.5 hours hypothermia-treatment (32.5 °C or normothermia (37 °C. ICP was monitored at baseline, for 3.5 hours post-occlusion, and at 24 hours post-stroke. Infarct and edema volumes were calculated from histology. Baseline pre-stroke ICP was 11.2 ± 3.3 mmHg across all animals. Twenty-four hours post-stroke, ICP was significantly higher in normothermic animals compared to hypothermia-treated animals (27.4 ± 18.2 mmHg vs. 8.0 ± 5.0 mmHg, p = 0.03. Infarct and edema volumes were not significantly different between groups. These data demonstrate ICP may also increase 24 hours post-stroke in aged rats, and that short-duration hypothermia treatment has a profound and sustained preventative effect. These findings may have important implications for the use of hypothermia in clinical trials of aged stroke patients.

  19. Refluxo laringofaringeano: estudo prospectivo correlacionando achados laringoscópicos precoces com a pHmanometria de 24 horas de 2 canais Laringopharingeal reflux: prospective study that compare early laryngoscopic finds and 2 channel and 24 hours esophageal testing

    Directory of Open Access Journals (Sweden)

    O. Marambaia

    grau de suspeição do especialista.Introduction: Laryngeal symptoms from the gastroesophageal reflux are increasing and being more common. Studies have shown high association with e "globus", cronic hoarseness and cronic cough. The diagnosis and treatment are different from the well known gastroesophageal reflux disease. Laryngeal endoscopy is the first exam to be done in laryngeal pacients. Laryngeal redness, thickness of space between arytenoids, granuloma, polyp, Reinke's swelling, subglottic's stenosis need a complete clinical investigation. 24 hour pHmetry and manometry are the choice, because its sensibility and espicificity. Aim: compare early clinical and laryngeal finds of laringopharingeal reflux with 24 hours pHmetry and manometry results. Evaluate responses to clinical terapy and dietary. Study design: clinical prospective randomized. Method: 61 adults with those cronic complaints: dry cough, "globus", to hawk, sialorrhoea, hoarseness, halitosis and choking. Pacients with another patology from airways were excluded. The laryngoscopy was important to select only recent lesions to do 24 hours pHmetry and manometry, and after if necessary try clinical treatment. Result: 83,6% had patologic reflux. More frequent symptoms were: hoarseness (72,5%, to hawk (60,8%, to cuugh (29,4%, "globus" (23,5% and sialorrhoea (19,6%. Frequency of associated symptoms: two (67,4%; three (41,2% and four (21,5%. 49 pacients have begun treatment with omeprazole and diet: 83,7% became better after 6 months. 95,9% of the treated patients had improved in laryncoscopy. Conclusions: Laryngeal endoscopy and clinical history had good correltions with 24 hours pHmetry and manometry results. Other studies would estabilsh rules to diagnosis and follow patients with laryngeal endoscopy. Working with other professionals is important to solve problems at this pathology.

  20. Refluxo laringofaringeano: estudo prospectivo correlacionando achados laringoscópicos precoces com a phmanometria de 24 horas de 2 canais Laringopharingeal reflux: prospective study that compare early laryngoscopic finds and 2 channel and 24 hours esophageal testing

    Directory of Open Access Journals (Sweden)

    O. Marambaia

    2002-08-01

    de suspeição do especialista.Introduction: Laryngeal symptoms from the gastroesophageal reflux are increasing and being more common. Studies have shown high association with e "globus", cronic hoarseness and cronic cough. The diagnosis and treatment are different from the well known gastroesophageal reflux disease. Laryngeal endoscopy is the first exam to be done in laryngeal pacients. Laryngeal redness, thickness of space between arytenoids, granuloma, polyp, Reinke's swelling, subglottic's stenosis need a complete clinical investigation. 24 hour pHmetry and manometry are the choice, because its sensibility and espicificity. Aim: compare early clinical and laryngeal finds of laringopharingeal reflux with 24 hours pHmetry and manometry results. Evaluate responses to clinical terapy and dietary. Study design: Clinical prospective: Material and Method: adults with those cronic complaints: dry cough, "globus", to hawk, sialorrhoea, hoarseness, halitosis and choking. Pacients with another patology from airways were excluded. The laryngoscopy was important to select only recent lesions to do 24 hour pHmetry and manometry, and after if necessary try clinical treatment. Results: 83,6% had patologic reflux. More frequent symptoms were: hoarseness (72,5%, to hawk (60,8%, to cough (29,4%, "globus" (23,5% and sialorrhoea (19,6%. Frequency of associated symptoms: two (67,4%; three (41,2% and four (21,5%. 49 pacients have begun treatment with omeprazole and diet: 83,7% became better after 6 months. 95,9% of the treated patients had improved in laryncoscopy. Conclusions: Laryngeal endoscopy and clinical history had good correlation with 24 hour pHmetry and manometry results. Other studies would estabilsh rules to diagnosis and follow patients with laryngeal endoscopy. Working with other professionals is important to solve problems at this pathology.

  1. How Hours of Work Affect Occupational Earnings.

    Science.gov (United States)

    Hecker, David

    1998-01-01

    In most managerial, management-related, sales, production, and transportation occupations, workers with longer hours earned a high hourly rate. The reverse was true for some jobs, including computer specialists, engineers, schoolteachers, and construction workers. (JOW)

  2. CERN restaurants: opening hours during summer

    CERN Multimedia

    2016-01-01

    In the summer, the three CERN restaurants remain open during their usual hours. On Monday 1st August and Thursday 8 September, the Restaurant 1 will be open from 7:00 a.m. to 10:00 p.m.   The satellites will be open as follows: Building 6: normal hours Building 13: normal hours Building 30: normal hours Building 40: closing at 4:30 p.m. instead of 5:00 pm Building 54: normal hours in July, closed in August Building 864: normal hours Building 865: normal hours Building 774: normal hours

  3. Work Hours Constraints: Impacts and Policy Implications

    OpenAIRE

    Constant, Amelie F.; Otterbach, Steffen

    2011-01-01

    If individuals reveal their preference as consumers, then they are taken seriously. What happens if individuals, as employees, reveal their preferences in working hours? And what happens if there is a misalignment between actual hours worked and preferred hours, the so-called work hours constraints? How does this affect the productivity of workers, their health, and overall life satisfaction? Labor supply and corresponding demand are fundamental to production. Labor economists know for long t...

  4. 75 FR 33664 - Hours of Service of Drivers: RockTenn, Application for Exemption

    Science.gov (United States)

    2010-06-14

    ... ``hurry back'' within 8 hours. As a result of the mandatory 10 hours off-duty requirement, RockTenn... drug testing, medical certification, and other driver-qualification requirements. RockTenn,...

  5. Ultrasonic vocalizations during intermittent swim stress forecasts resilience in subsequent forced swim and spatial learning tests.

    Science.gov (United States)

    Drugan, Robert C; Warner, Timothy A; Papallo, Tristan A; Castracane, Laura L; Stafford, Nathaniel P

    2014-02-01

    The examination of stress resilience has substantially increased in recent years. However, current paradigms require multiple behavioral procedures, which themselves may serve as secondary stressors. Therefore, a novel predictor of stress resilience is needed to advance the field. Ultrasonic vocalizations (USVs) have been observed as a behavioral correlate of stress in various rodent species. It was recently reported that rats that emitted ultrasonic vocalizations during intermittent swim stress (ISS) later showed resilience when tested on an instrumental swim escape test. In the current study, we extend this earlier observation on two additional behavioral endpoints. Rats were subjected to ISS, and USVs were recorded. Twenty-four hours later, behavioral performance was evaluated in either the forced swim test or Morris water maze. Rats that emitted ultrasonic vocalizations were resilient to the effects of ISS as indicated by performance similar to controls on both measures. These results extend the original findings that ISS-induced USVs are associated with resilience and are related to subsequent aversively motivated behavior. Such a non-invasive forecast of stress responsivity will allow future work to utilize USVs to examine the neural correlates of initial stress resistance/resilience, thereby eliminating potential confounds of further behavioral testing. Future studies can utilize USVs to target potentially unappreciated neural systems to provide novel pharmacotherapeutic strategies for treatment-resistant depression.

  6. Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers

    Science.gov (United States)

    Sanderson, Saskia C.; Wardle, Jane

    2005-01-01

    The aim of this study was to improve understanding of smokers' potential reactions to genetic testing for smoking-related diseases. One thousand twenty-four respondents completed a postal survey; 186 were smokers. Questions addressed anticipated psychological and behavioral reactions to genetic test results using hypothetical scenarios. Of…

  7. Walking in postpoliomyelitis syndrome: The relationships between time-scored tests, walking in daily life and perceived mobility problems

    NARCIS (Netherlands)

    H.L.D. Horemans (Herwin); J.B.J. Bussmann (Hans); A. Beelen (Anita); H.J. Stam (Henk); F. Nollet (Frans)

    2005-01-01

    textabstractObjective: To compare walking test results with walking in daily life, and to investigate the relationships between walking tests, walking activity in daily life, and perceived mobility problems in patients with post-poliomyelitis syndrome. Subjects: Twenty-four ambulant patients with po

  8. Will Genetic Testing for Complex Diseases Increase Motivation to Quit Smoking? Anticipated Reactions in a Survey of Smokers

    Science.gov (United States)

    Sanderson, Saskia C.; Wardle, Jane

    2005-01-01

    The aim of this study was to improve understanding of smokers' potential reactions to genetic testing for smoking-related diseases. One thousand twenty-four respondents completed a postal survey; 186 were smokers. Questions addressed anticipated psychological and behavioral reactions to genetic test results using hypothetical scenarios. Of…

  9. Long working hours and cancer risk

    DEFF Research Database (Denmark)

    Heikkila, Katriina; Nyberg, Solja T.; Madsen, Ida E. H.

    2016-01-01

    Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods: This multi-cohort study examined the association between working hours and cancer risk...... in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported. Results: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393......; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working greater than or equal to55 h...

  10. Determination of the Chronic Mammalian Toxicological Effects of RDX. Twenty-Four Month Chronic Toxicity/Carcinogenicity Study of Hexahydro-1,3,5- Trinitro-1,3,5-Triazine (RDX) in the B6C3F1 Hybrid Mouse. Phase 6. Volume 1

    Science.gov (United States)

    1984-04-01

    viruses : GD-VII virus , K virus , Mouse Adenovirus, Sendai virus , Reovirus 3...Pneumonia virus of mice, Lymphocytic Choriomeningitis, Polyoma virus , Minute virus of mice, Mouse Hepatitis and Ectomelia. These tests for antibody...OC" " N " N " NN C. C% N " C" N " C’ C" N N N C" C’ C, C" C" 04 C"J C" N C" C" N N" C"d N C" 04 04 C" CS C" C’) NCV C" cc I-XLU -I 0 1c Mc -tm WrL

  11. Teste ergométrico e o Holter de 24 horas na detecção de arritmias ventriculares complexas em diferentes estádios da cardiopatia chagásica crônica Exercise testing and 24 hours Holter monitoring in the detection of complex ventricular arrhythmias in different stages of chronic Chagas' heart disease

    Directory of Open Access Journals (Sweden)

    Roberto Coury Pedrosa

    2004-10-01

    Full Text Available Comparou-se o teste ergométrico com Holter de 24 horas na detecção de arritmias ventriculares complexas em diferentes estádios da cardiopatia chagásica crônica. Avaliados 71 pacientes sem outras doenças associadas, idade=51±10,3, metade mulheres. Divididos em quatro grupos conforme o grau de acometimento cardíaco. A estatística esta discriminada no corpo do trabalho. Ao Holter, no grupo IA as arritmias ventriculares complexas foram detectadas em 4,3%, IB em 25%, II em 55% e no grupo III em 90%. Nos grupos II e III não houve diferença entre os exames na detecção de arritmias ventriculares complexas (p=NS. Nos grupos IA e IB, houve uma concordância de 100% no teste ergométrico na não detecção de arritmias ventriculares complexas entre dois observadores. No grupo II, a concordância foi de 70% (kappa=0,368, p=0,003 e de 90% (kappa=0,78, p=0,002 no grupo III. Foi observado diferenças na presença de arritmias ventriculares complexas entre os pacientes dos grupos em fase inicial e avançada da cardiopatia chagásica crônica. Nos pacientes dos grupos II e III não houve diferença entre os dois exames na detecção das arritmias ventriculares complexas. Pacientes dos grupos IA e IB é razoável indicar Holter e/ou o teste ergométrico na ocorrência de progressão da doença.To detect complex ventricular arrhythmias in different stages of chronic chagasic cardiopathy, the results of exercise testing to 24 hours Holter monitoring have been compared. We evaluated a group of 71 patients, half women, aged 51±10.3, with no others associated diseases. These patients were separated in 4 groups according to degree of cardiac involvement. Statistical data can be found elsewhere in the study. In group IA, Holter monitoring detected 4.3% of complex ventricular arrhythmias, group IB 25%, group II 55% and group III 90%. We found no difference between Holter and exercise testing in the detection of complex ventricular arrhythmias in groups II

  12. Associations of Ischemic Lesion Volume With Functional Outcome in Patients With Acute Ischemic Stroke: 24-Hour Versus 1-Week Imaging.

    Science.gov (United States)

    Bucker, Amber; Boers, Anna M; Bot, Joseph C J; Berkhemer, Olvert A; Lingsma, Hester F; Yoo, Albert J; van Zwam, Wim H; van Oostenbrugge, Robert J; van der Lugt, Aad; Dippel, Diederik W J; Roos, Yvo B W E M; Majoie, Charles B L M; Marquering, Henk A

    2017-05-01

    Ischemic lesion volume (ILV) on noncontrast computed tomography at 1 week can be used as a secondary outcome measure in patients with acute ischemic stroke. Twenty-four-hour ILV on noncontrast computed tomography has greater availability and potentially allows earlier estimation of functional outcome. We aimed to assess lesion growth 24 hours after stroke onset and compare the associations of 24-hour and 1-week ILV with functional outcome. We included 228 patients from MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands), who received noncontrast computed tomography at 24-hour and 1-week follow-up on which ILV was measured. Relative and absolute lesion growth was determined. Logistic regression models were constructed either including the 24-hour or including the 1-week ILV. Ordinal and dichotomous (0-2 and 3-6) modified Rankin scale scores were, respectively, used as primary and secondary outcome measures. Median ILV was 42 mL (interquartile range, 21-95 mL) and 64 mL (interquartile range: 30-120 mL) at 24 hours and 1 week, respectively. Relative lesion growth exceeding 30% occurred in 121 patients (53%) and absolute lesion growth exceeding 20 mL occurred in 83 patients (36%). Both the 24-hour and 1-week ILVs were similarly significantly associated with functional outcome (both P<0.001). In the logistic analyses, the areas under the curve of the receiver-operator characteristic curves were similar: 0.85 (95% confidence interval, 0.80-0.90) and 0.87 (95% confidence interval, 0.82-0.91) for including the 24-hour and 1-week ILV, respectively. Growth of ILV is common 24-hour poststroke onset. Nevertheless, the 24-hour ILV proved to be a valuable secondary outcome measure as it is equally strongly associated with functional outcome as the 1-week ILV. URL: http://www.isrctn.com. Unique identifier: ISRCTN10888758. © 2017 American Heart Association, Inc.

  13. 24-Hour Academic Libraries: Adjusting to Change

    Science.gov (United States)

    Bowman, Adam C.

    2013-01-01

    The purpose of this study was to explore the adaptive measures that academic libraries perform when implementing and operating a 24-hour schedule. Five in-depth interviews were conducted with current managerial-level librarians at 24-hour academic libraries. The exploratory interviews revealed similar measures for security, budgeting, employee…

  14. 17 CFR 201.104 - Business hours.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business hours. 201.104 Section 201.104 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Rules of Practice General Rules § 201.104 Business hours. The Headquarters office of the Commission, at...

  15. 20 CFR 801.304 - Business hours.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Business hours. 801.304 Section 801.304 Employees' Benefits BENEFITS REVIEW BOARD, DEPARTMENT OF LABOR ESTABLISHMENT AND OPERATION OF THE BOARD Action by the Board § 801.304 Business hours. The office of the Clerk of the Board at Washington, DC...

  16. Cost-efficient staffing under annualized hours

    NARCIS (Netherlands)

    van der Veen, Egbert; Hans, Elias W.; Veltman, Bart; Berrevoets, Leo M.; Berden, Hubert J.J.M.

    2012-01-01

    We study how flexibility in workforce capacity can be used to efficiently match capacity and demand. Flexibility in workforce capacity is introduced by the annualized hours regime. Annualized hours allow organizations to measure working time per year, instead of per month or per week. An additional

  17. Caffeine withdrawal syndrome in social interaction test in mice: effects of the NMDA receptor channel blockers, memantine and neramexane.

    Science.gov (United States)

    Sukhotina, I A; Zvartau, E E; Danysz, W; Bespalov, A Y

    2004-05-01

    Antagonists acting at N-methyl-D-aspartate (NMDA) receptors have been demonstrated repeatedly to attenuate the expression of drug and alcohol withdrawal syndromes. The present study aimed to evaluate the effects of NMDA receptor blockade on the expression of behavioural signs of caffeine withdrawal syndrome, assessed using the social interaction paradigm. Adult male Swiss mice were treated with increasing doses of caffeine (40-100 mg/kg, i.p., twice daily) for 8 days. Twenty-four hours after the last injection of caffeine, there were significant increases in duration and frequency of defensive behaviours, as well as decreased locomotor activity. These changes faded within 72 hours. Pretreatment with a single dose of caffeine (1 mg/kg; 24 h after the end of repeated caffeine administration and 30 min prior to the test) completely reversed these withdrawal-related changes. Separate groups of mice were treated i.p. with different doses of memantine (1, 3 or 10 mg/kg) or neramexane (MRZ 2/579; 1, 3 or 10 mg/kg) 24 h after the last caffeine injection. Both compounds dose-dependently reduced the expression of defensive behaviours while increasing motor activity. These data suggest that NMDA receptor blockade may counteract the acute behavioural effects of caffeine withdrawal.

  18. Duty hours and incidents in flight among commercial airline pilots.

    Science.gov (United States)

    O'Hagan, Anna Donnla; Issartel, Johann; Fletcher, Richard; Warrington, Giles

    2016-01-01

    Working long duty hours has often been associated with increased risk of incidents and accidents in transport industries. Despite this, information regarding the intermediate relationship between duty hours and incident risk is limited. This study aimed to test a work hours/incident model to identify the interplay of factors contributing to incidents within the aviation industry. Nine hundred and fifty-four European-registered commercial airline pilots completed a 30-item survey investigating self-report attitudes and experiences of fatigue. Path analysis was used to test the proposed model. The fit indices indicated this to be a good fit model (χ(2) = 11.066, df = 5, p = 0.05; Comparative Fit Index = 0.991; Normed Fit Index = 0.984; Tucker-Lewis Index = 0.962; Root Mean Square of Approximation = 0.036). Highly significant relationships were identified between duty hours and sleep disturbance (r = 0.18, p < 0.001), sleep disturbance and fatigue in the cockpit (r = 0.40, p < 0.001), and fatigue in the cockpit and microsleeps in the cockpit (r = 0.43, p < 0.001). A critical pathway from duty hours through to self-reported incidents in flight was identified. Further investigation employing both objective and subjective measures of sleep and fatigue is needed.

  19. Epidemiology of hyperbilirubinemia in the first 24 hours after birth

    Directory of Open Access Journals (Sweden)

    Zarrinkoub F

    2007-09-01

    Full Text Available   Background: Jaundice is one of the most frequent problems observed in newborns. Our purpose was to investigate the incidence and the risk factors on jaundice noted in the first 24 hours after birth.Methods: All newborns observed to have jaundice within the first 24 hours after birth were enrolled prospectively in this study. Laboratory evaluations included blood group typing of mother and newborn, hemoglobin and hematocrit, complete blood count, peripheral blood smear, reticulocyte count, G6PD activity, maternal indirect and neonatal direct Coombs test, and serum total, conjugated, and unconjugated bilirubin. In all cases, gender, birth weight, Apgar scores, gestational age, mode of delivery, birth trauma, cephalhematoma, maternal age, parity, or any siblings with neonatal jaundice were recorded. Data were analyzed using one-way ANOVA, Student's t-, and chi-square tests.Results: Of a total of 2096 newborns delivered in one year, 122 (5.8% developed jaundice within the first 24 hours after birth. Risk factors for hyperbilirubinemia were ABO incompatibility, prematurity, infection, G6PD deficiency, cephalhematoma, asphyxia, and Rh disease. There were no statistically significant relationships between jaundice and maternal age, parity, mode of delivery, neonatal gender or previous siblings with jaundice (p>0.05.Conclusions: Jaundice observed in the initial 24 hours after birth was infrequent, but clinically significant. All newborns should be followed by repeated exams within the first 24 hours after birth and before discharge, especially if the maternal blood group is O.

  20. Effects of renal sympathetic denervation on 24-hour blood pressure variability

    Directory of Open Access Journals (Sweden)

    Christine Stefanie Zuern

    2012-05-01

    Full Text Available Background: In patients with arterial hypertension, increased blood pressure (BP variability contributes to end organ damage independently from mean levels of arterial BP. Increased BP variability has been linked to alterations in autonomic function including sympathetic overdrive. We hypothesized that catheter-based renal sympathetic denervation (RDN confers beneficial effects on BPV. Methods and Results: Eleven consecutive patients with therapy-refractory arterial hypertension (age 68.9±7.0 years; baseline systolic BP 189±23mmHg despite medication with 5.6±2.1 antihypertensive drugs underwent bilateral RDN. Twenty-four hour ambulatory blood pressure monitoring (ABPM was performed before RDN and six months thereafter. BPV was primarily assessed by means of standard deviation of 24-hour systolic arterial blood pressures (SDsys. Secondary measures of BPV were maximum systolic blood pressure (MAXsys and maximum difference between two consecutive readings of systolic BP (deltamaxsys over 24 hours. Six months after RDN, SDsys, MAXsys and deltamaxsys were significantly reduced from 16.9±4.6mmHg to 13.5±2.5mmHg (p=0.003, from 190±22mmHg to 172±20mmHg (p<0.001 and from 40±15mmHg to 28±7mmHg (p=0.006, respectively, without changes in concomitant antihypertensive therapy. Reductions of SDsys, MAXsys and deltamaxsys were observed in 10/11 (90.9%, 11/11 (100% and 9/11 (81.8% patients, respectively. Although we noted a significant reduction of systolic office blood pressure by 30.4±27.7mmHg (p=0.007, there was only a trend in reduction of average systolic BP assessed from ABPM (149±19mmHg to 142±18mmHg; p=0.086.Conclusions: In patients with therapy-refractory arterial hypertension, RDN leads to significant reductions of BP variability. Effects of RDN on BPV over 24 hours were more pronounced than on average levels of BP.

  1. A Century of Human Capital and Hours

    OpenAIRE

    Diego Restuccia; Guillaume Vandenbroucke

    2012-01-01

    An average person born in the United States in the second half of the nineteenth century completed 7 years of schooling and spent 58 hours a week working in the market. By contrast, an average person born at the end of the twentieth century completed 14 years of schooling and spent 40 hours a week working. In the span of 100 years, completed years of schooling doubled and working hours decreased by 30 percent. What explains these trends? We consider a model of human capital and labor supply t...

  2. Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate

    Institute of Scientific and Technical Information of China (English)

    LIU Li-wei; LIU Hong; CHEN Guo-liang; HUANG Yi-ling; HAN Lu-lu; XU Zhi-min; JIANG Xiong-jing; LI Yi-shi

    2010-01-01

    Background Genetic factors can influence antihypertensive response to metoprolol, and many studies focused on the relationship between the genotype in β1-adrenergic receptor and blood pressure (BP), little was known about the association of angiotensin-converting enzyme (ACE) genotype with the therapeutic result of metoprolol. The present study aimed to investigate whether the ACE gene insertion (I) / deletion (D) polymorphism Is related to the response to metoprolol in Chinese Han hypertensive patients.Methods Ninety-six patients with essential hypertension received metoprolol (100 mg once daily) as monotherapy for 8 weeks. Twenty-four hours ambulatory blood pressure monitoring and dynamic electrocardiogram were performed before and after treatment. Genotyping analysis was performed using PCR. The association of the ACE gene I/D polymorphism with variations in BP and heart rate (HR) was observed after the 8-week treatment.Results The patients with ACE gene II polymorphism showed greater reduction in 24-hour average HR than those with ID or DD polymorphisms (P=0.045), no effect of this genotype on the reduction in seating HR or in BP was observed. After adjusting for age, gender, body mass index, BP and HR at baseline, the ACE gene I/D polymorphism was still an independent predictor for variations in 24-hour average HR.Conclusions The II polymorphism in ACE gene could be a candidate predictor for greater reduction in 24-hour average HR in Chinese Han hypertensive patients treated by metoprolol. Greater benefits would be obtained by patients with II polymorphism from the treatment with metoprolol. Larger studies are warranted to validate this finding.

  3. Ozone Nonattainment Areas - 8 Hour (1997 Standard)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data layer identifies areas in the U.S. where air pollution levels have not met the National Ambient Air Quality Standards (NAAQS) for ozone over 8 hours and...

  4. U.S. Hourly Precipitation Data Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This publication contains hourly precipitation amounts obtained from recording rain gages located at National Weather Service, Federal Aviation Administration, and...

  5. U.S. Hourly Precipitation Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hourly Precipitation Data (HPD) is digital data set DSI-3240, archived at the National Climatic Data Center (NCDC). The primary source of data for this file is...

  6. SO2 8 Hour Nonattainment Areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data layer identifies areas in the U.S. where air pollution levels have not met the National Ambient Air Quality Standards (NAAQS) for Sulfur dioxide 8 hour...

  7. Recurrence Within 24 Hours of Unprovoked Seizures

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2006-09-01

    Full Text Available The incidence and risk factors of acute recurrence of unprovoked seizures within 24 hours of admission to an Emergency Department (ED were analyzed by a retrospective chart review at Schneider Children’s Hospital, New York.

  8. Long working hours and alcohol use

    DEFF Research Database (Denmark)

    Virtanen, Marianna; Jokela, Markus; Nyberg, Solja T

    2015-01-01

    OBJECTIVE: To quantify the association between long working hours and alcohol use. DESIGN: Systematic review and meta-analysis of published studies and unpublished individual participant data. DATA SOURCES: A systematic search of PubMed and Embase databases in April 2014 for published studies......, supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies. REVIEW METHODS: The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were.......20) in the analysis of prospective published and unpublished data. In the 18 studies with individual participant data it was possible to assess the European Union Working Time Directive, which recommends an upper limit of 48 hours a week. Odds ratios of new onset risky alcohol use for those working 49-54 hours...

  9. A composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats.

    Science.gov (United States)

    McBride, Devin W; Nowrangi, Derek; Kaur, Harpreet; Wu, Guangyong; Huang, Lei; Lekic, Tim; Tang, Jiping; Zhang, John H

    2017-01-01

    Cerebellar haemorrhage accounts for 5-10% of all intracerebral haemorrhages and leads to severe, long-lasting functional deficits. Currently, there is limited research on this stroke subtype, which may be due to the lack of a suitable composite neuroscoring system specific for cerebellar injury in rodents. The purpose of this study is to develop a comprehensive composite neuroscore test for cerebellar injury using a rat model of cerebellar haemorrhage. Sixty male Sprague-Dawley rats were subjected to either sham surgery or cerebellar haemorrhage. Twenty-four hours post-injury, neurological behaviour was evaluated using 17 cost-effective and easy-to-perform tests, and a composite neuroscore was developed. The composite neuroscore was then used to assess functional recovery over seven days after cerebellar haemorrhage. Differences in the composite neuroscore deficits for the mild and moderate cerebellar haemorrhage models were observed for up to five days post-ictus. Until now, a composite neuroscore for cerebellar injury was not available for rodent studies. Herein, using mild and moderate cerebellar haemorrhage rat models a composite neuroscore for cerebellar injury was developed and used to assess functional deficits after cerebellar haemorrhage. This composite neuroscore may also be useful for other cerebellar injury models.

  10. Longer opening hours, alcohol consumption and health

    OpenAIRE

    Green, Colin Peter; Hollingsworth, Bruce Philip; Navarro Paniagua, Maria

    2015-01-01

    Two related issues in public policy with respect to alcohol are how increased availability influences consumption and what effect excess consumption has on individual health outcomes. This paper examines one particular source of variation in availability, bar opening hours, and how this influences alcohol consumption, physical and mental health. We focus on the extension of opening hours in England and Wales that occurred in 2005. We demonstrate a marked increase in consumption, which appears...

  11. Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

    DEFF Research Database (Denmark)

    Sokka, Tuulikki; Hetland, Merete Lund; Mäkinen, Heidi;

    2008-01-01

    OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5...... exercise were statistically significantly associated with remission. CONCLUSION: The use of different definitions of RA remission leads to different results with regard to remission rates, with considerable variation among countries and between sexes. Reported remission rates in clinical trials...

  12. Twenty-four near-instabilities of Caspar-Klug viruses

    Science.gov (United States)

    Englert, François; Peeters, Kasper; Taormina, Anne

    2008-09-01

    Group theoretical arguments combined with normal mode analysis techniques are applied to a coarse-grained approximation of icosahedral viral capsids which incorporates areas of variable flexibility. This highlights a remarkable structure of the low-frequency spectrum in this approximation, namely, the existence of a plateau of 24 near zero modes with universal group theory content.

  13. LECTURES ON ACUPUNCTURE Part Ⅰ Clinical Acupuncture Lecture Twenty-Four "XIONGBI" (CHEST PAIN) SYNDROME

    Institute of Scientific and Technical Information of China (English)

    Dong Hongying; Guo Ling; Shang Xiukui

    2001-01-01

    @@ "Xiongbi" chest (or precordial) pain with stuffiness, or chest pain syndrome is referred to choking pain in the chest due to stagnation of chest -yang, failure of qi and blood in warming and nourishing the local meridians. It is usually caused by stagnation of dampness and phlegm in the interior, or by insufficiency of qi and blood stasis, leading to impeded flow of qi and blood in the heart vessels. Its pathological characteristics are deficiency (chest-yang) in origin and excess (i. e., qi stagnation) in superficiality. The therapeutic principles are promoting blood circulation to remove blood stasis, getting rid of blockage and dredging the passages of yang-qi.

  14. Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

    DEFF Research Database (Denmark)

    Sokka, Tuulikki; Hetland, Merete Lund; Mäkinen, Heidi

    2008-01-01

    OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5...

  15. Autistic children grow up: an eight to twenty-four year follow-up study.

    Science.gov (United States)

    Wolf, L; Goldberg, B

    1986-08-01

    Eighty questionnaires were sent to parents and/or caregivers of autistic persons diagnosed between 1960-73 at CPRI, a regional assessment and treatment centre. The objective was to determine their present place of residence, functioning ability, language development, program involvement, and seizure activity. The results of this study support evidence that more than 50 percent require long-term institutional care; almost one-third suffer epileptic seizures; there is a persistence of symptoms and difficulty in gaining useful speech; few live independently or are capable of employment.

  16. Total antioxidant and antiproliferative activities of twenty-four Vitis vinifera grapes

    Science.gov (United States)

    The phytochemical profiles of 24 Vitis vinifera grape cultivars, including total phenolics, total flavonoids, total antioxidant activity and antiproliferative activity, were determined. Total phenolic contents in the cultivars ranged from 95.3 to 686.5 mg of gallic acid equivalents/100 g FW, and to...

  17. Twenty-Four Veterinary Anatomic Fibs, Half-Truths, and Misleading Statements.

    Science.gov (United States)

    Shively, Michael Jay

    1979-01-01

    A number of statements about well-established information in veterinary anatomy are debated and refuted: (1) sesamoid bones change the direction of tendons, (2) tendons are composed of collagenous connective tissue, (3) anal glands are synonymous with anal sacs, (4) reciprocal apparatus is part of stay apparatus, etc. (Author/MLW)

  18. Community Energy Systems and the Law of Public Utilities. Volume Twenty-four. Michigan

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.

    1981-01-01

    A detailed description of the laws and programs of the State of Michigan governing the regulation of public energy facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities - Volume One: An Overview. This report also contains a summary of a strategy described in Volume One - An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

  19. 77 FR 47631 - Agency Information Collection Activities: Request for Comments on Twenty-Four Proposed...

    Science.gov (United States)

    2012-08-09

    ...: NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH). ICR Numbers: EPA ICR..., 2012. (9) NSPS for Synthetic Fiber Production Facilities (40 CFR Part 60, Subpart HHH); Learia Williams... Part 60, Subpart HHH); Docket ID Number EPA-HQ-OECA-2012-0528; EPA ICR Number 1156.12; OMB...

  20. A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma

    Directory of Open Access Journals (Sweden)

    R.E. Shackelford

    2017-05-01

    Full Text Available A 24-year-old woman presented with a 5-month history of a left flank mass that was painful on palpation. Magnetic resonance imaging revealed a 10.0 × 6.0 × 2.5 cm mass consistent with lipoma. A fatty lobulated mass was excised and subjected to H&E staining and immunohistochemical analyses. The specimen consisted of mature univacuolated adipocytic cells, with intermixed multivacuolated eosinophilic granular cells. No atypia or hyperchromasia was identified. Most of the cells were S100 positive and Ki-67 immunonegative. A diagnosis of a lipoma-like hibernoma was rendered. Hibernomas are rare benign lipomatous tumors that show differentiation toward brown fat. The lipoma-like hibernoma subtype is rare and can be misdiagnosed as atypical lipoma or well-differentiated liposarcoma. Here we describe an example of this rare tumor.

  1. Twenty-four years of follow-up for a Hanford plutonium wound case.

    Science.gov (United States)

    Carbaugh, Eugene H; Lynch, Timothy P; Antonio, Cheryl L; Medina-Del Valle, Fernando

    2010-10-01

    A 1985 plutonium puncture wound resulted in the initial deposition of 48 kBq of transuranic alpha activity, primarily 239+240Pu and 241Am, in a worker's right index finger. Surgical excisions in the week following reduced the long-term residual wound activity to 5.4 kBq, and 164 DTPA chelation therapy administrations over 17 mo resulted in urinary excretion of about 7 kBq. The case was published in 1988, but now 24 y of follow-up data are available. Annual bioassays have included in-vivo measurements of 241Am in the wound, skeleton, liver, lung, and axillary lymph nodes, and urinalyses for plutonium and 241Am. These measurements have shown relatively stable levels of 241Am at the wound site, with gradually increasing amounts of 241Am detected in the skeleton. Liver measurements have shown erratic detection of 241Am, and the lung measurements indicate Am but as interference from activity in the axillary lymph nodes and skeleton rather than activity in the lung. Urine excretion of Pu since termination of chelation therapy has typically ranged from 10 to 20 mBq d, with Am excretion about 10% of that for 239+240Pu. Annual routine medical exams have not identified any adverse health effects associated with the intake.

  2. How extreme is extreme hourly precipitation?

    Science.gov (United States)

    Papalexiou, Simon Michael; Dialynas, Yannis G.; Pappas, Christoforos

    2016-04-01

    The importance of accurate representation of precipitation at fine time scales (e.g., hourly), directly associated with flash flood events, is crucial in hydrological design and prediction. The upper part of a probability distribution, known as the distribution tail, determines the behavior of extreme events. In general, and loosely speaking, tails can be categorized in two families: the subexponential and the hyperexponential family, with the first generating more intense and more frequent extremes compared to the latter. In past studies, the focus has been mainly on daily precipitation, with the Gamma distribution being the most popular model. Here, we investigate the behaviour of tails of hourly precipitation by comparing the upper part of empirical distributions of thousands of records with three general types of tails corresponding to the Pareto, Lognormal, and Weibull distributions. Specifically, we use thousands of hourly rainfall records from all over the USA. The analysis indicates that heavier-tailed distributions describe better the observed hourly rainfall extremes in comparison to lighter tails. Traditional representations of the marginal distribution of hourly rainfall may significantly deviate from observed behaviours of extremes, with direct implications on hydroclimatic variables modelling and engineering design.

  3. Long working hours and alcohol use

    DEFF Research Database (Denmark)

    Virtanen, Marianna; Jokela, Markus; Nyberg, Solja T

    2015-01-01

    OBJECTIVE: To quantify the association between long working hours and alcohol use. DESIGN: Systematic review and meta-analysis of published studies and unpublished individual participant data. DATA SOURCES: A systematic search of PubMed and Embase databases in April 2014 for published studies......, supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies. REVIEW METHODS: The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were...... countries. The pooled maximum adjusted odds ratio for the association between long working hours and alcohol use was 1.11 (95% confidence interval 1.05 to 1.18) in the cross sectional analysis of published and unpublished data. Odds ratio of new onset risky alcohol use was 1.12 (1.04 to 1...

  4. Longer Opening Hours for the Library

    CERN Multimedia

    2001-01-01

    The scientific information service. The CERN library is open 24 hours a day, 365 days a year. So how, you might be wondering, can they improve on that? The answer is in the detail. Although you can already use the library whenever you want, items can only be checked out when the front desk is staffed. A decision taken last week by the Scientific Information Policy Board now means that there will someone at the desk through out CERN's official working hours, with an extra 90 minutes at the end of the day so that people can check out material on their way home. In other words, the library will be open from 8:30 to 19:00, Monday to Friday. The library continues, of course, to be open 24 hours a day, all year round, and services provided via the digital library remain at your disposal day and night: http://library.cern.ch

  5. Avoiding Lawsuits for Wage and Hour Violations.

    Science.gov (United States)

    Silberman, Cherie L

    2016-01-01

    Due to the highly technical language in the wage and hour laws and regulations, employers often find that they have unknowingly violated the Fair Labor Standards Act (FLSA). This can occur because employers have improperly classified an employee as exempt or because employers do not realize that certain time should be paid in full. Improperly classifying employees as exempt or failing to compensate nonexempt employees for all time worked can lead to costly lawsuits, audits, or enforcement actions by the Wage and Hour Division of the Department of Labor. This article discusses the most common FLSA exemptions and provides best practices to avoid liability under the FLSA.

  6. 29 CFR 778.110 - Hourly rate employee.

    Science.gov (United States)

    2010-07-01

    ... number of hours worked in excess of 40 in the week. Thus a $6 hourly rate will bring, for an employee who....80 for 46 hours (46 hours at $6.20 plus 6 hours at $3.10, or 40 hours at $6.20 plus 6 hours at $9.30). ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF...

  7. Estimation of clear sky hourly global solar radiation in Iraq

    Energy Technology Data Exchange (ETDEWEB)

    Al-Jumaily, Kais J.; Al-Zuhairi, Munya F.; Mahdi, Zahraa S. [Department of Atmospheric Sciences, College of Science, Al-Mustansiriyah University, Baghdad (Iraq)

    2012-07-01

    The availability of hourly solar radiation data is very important for applications utilizing solar energy and for climate and environmental aspects. The aim of this work is to use a simple model for estimating hourly global solar radiation under clear sky condition in Iraq. Calculations were compared with measurements obtained from local station in Baghdad city and from Meteosat satellite data for different locations in Iraq. The statistical test methods of the mean bias error (MBE), root mean square error (RMSE) and t-test were used to evaluate the performance of the model. Results indicated that a fairly good agreement exists between calculated and measured values for all locations in Iraq. Since the model is independent of any meteorological variable, it would be of a practical use for rural areas where no meteorological data are available.

  8. Simplified hourly method to calculate summer temperatures in dwellings

    DEFF Research Database (Denmark)

    Mortensen, Lone Hedegaard; Aggerholm, Søren

    2012-01-01

    The objective of this study was to develop a method for hourly calculation of the operating temperature in order to evaluate summer comfort in dwellings to help improve building design. A simplified method was developed on the basis of the simple hourly method of the standard ISO 13790...... program for thermal simulations of buildings. The results are based on one year simulations of two cases. The cases were based on a low energy dwelling of 196 m². The transmission loss for the building envelope was 3.3 W/m², not including windows and doors. The dwelling was tested in two cases, a case...... for the fulfilment of summer comfort. Thus it is very important to address both opening areas and ventilation rates. The developed simplified method makes it possible to test whether or not a building design for a dwelling will prevent excess of the summer comfort limits set by the building regulations....

  9. Analysis of Office/Laboratory Staying Hour and Home Working Hour of Japanese Scientists and Engineers

    Science.gov (United States)

    Ejiri, A.

    The second questionnaire for scientists and engineers was carried out in 2007, and status of Japanese scientists and engineers were analyzed and reported. A part of the data was reanalyzed from the viewpoint of work life balance. In particular, office/laboratory staying hour and home working hour were analyzed and dependences on various factors were investigated. It was found that these hours depend on gender, marital status, number of child, employment status and age. In addition, the total hours tend to be kept constant regardless of various factors.

  10. Installation Service - Changes in opening hours

    CERN Multimedia

    GS Department

    2010-01-01

    For organizational matters, please note that, as from 15 March 2010, the Installation Service will have wen opening hours. The new schedule will be from 14:00 to 17:00 (Monday to Friday). Contact persons are: Martine Briant, Karine Robert and Claudia Bruggmann. The office address remains 73-3-014. Installation Service

  11. Why Surface Nanobubbles Live for Hours

    NARCIS (Netherlands)

    Weijs, Joost; Lohse, Detlef

    2013-01-01

    We present a theoretical model for the experimentally found but counterintuitive exceptionally long lifetime of surface nanobubbles. We can explain why, under normal experimental conditions, surface nanobubbles are stable for many hours or even up to days rather than the expected microseconds. The

  12. 10 CFR 26.205 - Work hours.

    Science.gov (United States)

    2010-01-01

    ..., training, or pre-shift briefings for special evolutions; and holdovers for interviews needed for event... waivers under which work was performed to evaluate staffing adequacy for all jobs subject to the work hour...; and (4) Record, trend, and correct, under the licensee's corrective action program, any problems...

  13. Electoral (Amendment) (Hours of Polling) Bill 2013

    DEFF Research Database (Denmark)

    Butler, Graham; Hunt, Brian; Doyle, Andrew

    2013-01-01

    Private Members' Bill (legislation) introduced in Dáil Éireann (House of Deputies), Houses of the Oireachtas (Parliament of Ireland). An Act to set voting hours for Dáil Elections, Dáil Bye-Elections, Presidential Elections, European Parliament Elections, Local Government Elections and Referenda...

  14. The 24-Hour Mathematical Modeling Challenge

    Science.gov (United States)

    Galluzzo, Benjamin J.; Wendt, Theodore J.

    2015-01-01

    Across the mathematics curriculum there is a renewed emphasis on applications of mathematics and on mathematical modeling. Providing students with modeling experiences beyond the ordinary classroom setting remains a challenge, however. In this article, we describe the 24-hour Mathematical Modeling Challenge, an extracurricular event that exposes…

  15. Analysis of The Story of An Hour

    Institute of Scientific and Technical Information of China (English)

    曹玉琴

    2014-01-01

    By reading the short story The Story of An Hour written by Kate Chopin, we tried to probe the story better by analyz-ing five characters, plots of the story and rhetorical devices, such as irony and symbolism. With originality and profound mean-ings, the novel about the small theme of family life had a wide variety of social significance.

  16. Estimator's electrical man-hour manual

    CERN Document Server

    Page, John S

    1999-01-01

    This manual's latest edition continues to be the best source available for making accurate, reliable man-hour estimates for electrical installation. This new edition is revised and expanded to include installation of electrical instrumentation, which is used in monitoring various process systems.

  17. Inter- and intraobserver agreement in 24-hour combined multiple intraluminal impedance and pH measurement in children.

    Science.gov (United States)

    Pilic, Denisa; Höfs, Carolin; Weitmann, Sandra; Nöh, Frank; Fröhlich, Thorsten; Skopnik, Heino; Köhler, Henrik; Wenzl, Tobias G; Schmidt-Choudhury, Anjona

    2011-09-01

    Assessment of intra- and interobserver agreement in multiple intraluminal impedance (MII) measurement between investigators from different institutions. Twenty-four 18- to 24-hour MII tracings were randomly chosen from 4 different institutions (6 per center). Software-aided automatic analysis was performed. Each result was validated by 2 independent investigators from the 4 different centers (4 investigator combinations). For intraobserver agreement, 6 measurements were analyzed twice by the same investigator. Agreement between investigators was calculated using the Cohen kappa coefficient. Interobserver agreement: 13 measurements showed a perfect agreement (kappa > 0.8); 9 had a substantial (kappa 0.61-0.8), 1 a moderate (kappa coefficient 0.41 to 0.6), and 1 a fair agreement (kappa coefficient 0.11-0.4). Median kappa value was 0.83. Intraobserver agreement: 5 tracings showed perfect and 1 showed a substantial agreement. The median kappa value was 0.88. Most measurements showed substantial to perfect intra- and interobserver agreement. Still, we found a few outliers presumably caused by poorer signal quality in some tracings rather than being observer dependent. An improvement of analysis results may be achieved by using a standard analysis protocol, a standardized method for judging tracing quality, better training options for method users, and more interaction between investigators from different institutions.

  18. Hourly associations between heat and ambulance calls.

    Science.gov (United States)

    Guo, Yuming

    2017-01-01

    The response speed of ambulance calls is very crucial to rescue patients suffering immediately life threatening conditions. The serious health outcomes might be caused by exposing to extreme heat only several hours before. However, limited evidence is available on this topic. This study aims to examine the hourly association between heat and ambulance calls, to improve the ambulance services and to better protect health. Hourly data on ambulance calls for non-accidental causes, temperature and air pollutants (PM10, NO2, and O3) were collected from Brisbane, Australia, during 2001 and 2007. A time-stratified case-crossover design was used to examine the associations between hourly ambulance calls and temperature during warm season (Nov, Dec, Jan, Feb, and Mar), while adjusting for potential confounders. Stratified analyses were performed for sex and age groups. Ambulance calls peaked at 10am for all groups, except those aged heat-ambulance calls relationships were non-linear for all groups, with thresholds between 27 °C and 31 °C. The associations appeared immediately, and lasted for about 24 h. There were no significant modification effect by sex and age. The findings suggest that hot hourly temperatures (>27 °C) increase the demands of ambulance. This information is helpful to increase the efficiency of ambulance service then save lives, for example, preparing more ambulance before appearance of extremely hot temperature in combination with weather forecast. Also, people should better arrange their time for outdoor activities to avoid exposing to extreme hot temperatures. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Correlation of spot urine protein-creatinine ratio with 24-hour urinary protein in type 2 diabetes mellitus patients: A cross sectional study

    Directory of Open Access Journals (Sweden)

    Satish Basanagouda Biradar

    2011-01-01

    Full Text Available Background: Diabetic nephropathy is the major cause for chronic renal failure (CRF and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management. Methods: This study was conducted amongst 42 diabetic subjects from HSK hospital, Bagalkot. Twenty four-hour urine protein and random urine protein to creatinine ratio (P:C was determined. Pearson′s correlation, sensitivity, specificity, positive and negative predictive values were determined using 24-hour urinary protein as a gold standard for spot urine P:C ratio. ROC curve and area under curve was also determined using SPSS (11.5 software. All the results were expressed in mean±SD. Results: Forty two diabetes mellitus patients participated in this study. The average of 24 hour urinary protein was 1.6 ± 1.7 gm/day. The spot urine P:C ratio was 1.27 ± 1.55. There was a positive correlation between 24 hours urinary protein and spot urine P:C ratio (r = 0.925, p < 0.0001. The area under the ROC curve for urine P:C ratio at various cutoff was 0.947 (95% confidence interval: 0.831-0.992, p < 0.0001. The sensitivity and specificity was 80.65% and 100% respectively at P:C ratio cutoff of 0.3. Conclusions: The random urine P:C ratio predicts the amount of 24-hour urinary protein excretion with high accuracy. Hence it can be used as a faster diagnostic substitute for 24-hour urinary protein estimation.

  20. Long working hours and alcohol use

    DEFF Research Database (Denmark)

    Virtanen, Marianna; Jokela, Markus; Nyberg, Solja T

    2015-01-01

    , supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies. REVIEW METHODS: The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were...... obtained with random effects meta-analysis. Sources of heterogeneity were examined with meta-regression. RESULTS: Cross sectional analysis was based on 61 studies representing 333,693 participants from 14 countries. Prospective analysis was based on 20 studies representing 100,602 participants from nine...... countries. The pooled maximum adjusted odds ratio for the association between long working hours and alcohol use was 1.11 (95% confidence interval 1.05 to 1.18) in the cross sectional analysis of published and unpublished data. Odds ratio of new onset risky alcohol use was 1.12 (1.04 to 1...

  1. Why surface nanobubbles live for hours

    CERN Document Server

    Weijs, Joost H

    2012-01-01

    We present a theoretical model for the experimentally found but counter-intuitive exceptionally long lifetime of surface nanobubbles. We can explain why, under normal experimental conditions, surface nanobubbles are stable for many hours or even up to days rather than the expected microseconds. The limited gas diffusion through the water in the far field, the cooperative effect of nanobubble clusters, and the pinned contact line of the nanobubbles lead to the slow dissolution rate.

  2. Optimum Arrangement of Taxi Drivers’ Working Hours

    OpenAIRE

    TANIZAKI, Takashi

    2014-01-01

    Part 2: Knowledge Discovery and Sharing; International audience; We propose optimum arrangement of taxi drivers’ working hours. In Japan, income of taxi vehicle is decreasing about 11 thousand yen in the past 15 years. Then some taxi companies are investing to gain more customers. But there are many small taxi companies that are difficult to invest with much money. Therefore we have been researching the other method to gain more customers by little investment for small companies. In this pape...

  3. Hourly Spectral Variability of Mrk 421

    CERN Document Server

    Krennrich, F; Boyle, P J; Bradbury, S M; Buckley, J H

    2003-01-01

    Mrk 421 is the first TeV blazar found to exhibit significant spectral variability during strong flaring activity, showing hardening of the TeV spectrum in high emission states. Mrk 421 is also known to exhibit flux variability on time scales as short as 15 minutes. In this paper we present studies of hourly spectral variability of Mrk 421 in 2001 using data from the Whipple Observatory 10m gamma-ray telescope.

  4. Resolving issues concerning Eskdalemuir geomagnetic hourly values

    Directory of Open Access Journals (Sweden)

    S. Macmillan

    2011-02-01

    Full Text Available The hourly values of the geomagnetic field from 1911 to 1931 derived from measurements made at Eskdalemuir observatory in the UK, and available online from the World Data Centre for Geomagnetism at http://www.wdc.bgs.ac.uk/, have now been corrected. Previously they were 2-point averaged and transformed from the original north, east and vertical down values in the tables in the observatory yearbooks. This paper documents the course of events from discovering the post-processing done to the data to the final resolution of the problem. As it was through the development of a new index, the Inter-Hour Variability index, that this post-processing came to light, we provide a revised series of this index for Eskdalemuir and compare it with that from another European observatory. Conclusions of studies concerning long-term magnetic field variability and inferred solar variability, whilst not necessarily consistent with one another, are not obviously invalidated by the incorrect hourly values from Eskdalemuir. This series of events illustrates the challenges that lie ahead in removing any remaining errors and inconsistencies in the data holdings of different World Data Centres.

  5. CERN takes part in Earth Hour

    CERN Multimedia

    Anaïs Vernède

    2011-01-01

    From 8.30 to 9.30 p.m. on Saturday, 26 March 2011, the Globe of Science and Innovation will be plunged into darkness to mark CERN's participation in Earth Hour. A growing number of countries and cities across the planet are involved in this global initiative against climate change, which was launched by the WWF in 2007.   The lights on the Globe were switched off for the 2009 Earth Hour event. Along with individuals, companies and tourist attractions in thousands of towns and cities all over the world participating in the fourth annual Earth Hour event, CERN will turn off the lights of the Globe for 60 minutes at 8.30 p.m. on Saturday 26 March. CERN's participation in the initiative is one of several examples of its commitment to respect the environment and keep its ecological footprint to the minimum. A recent example under the green transport heading was the replacement of part of CERN's petrol vehicle fleet with cars running on natural gas with a view to reducing air pollution. Other examples...

  6. Detection of vancomycin resistances in enterococci within 3 ½ hours.

    Science.gov (United States)

    Schröder, U-Ch; Beleites, C; Assmann, C; Glaser, U; Hübner, U; Pfister, W; Fritzsche, W; Popp, J; Neugebauer, U

    2015-02-03

    Vancomycin resistant enterococci (VRE) constitute a challenging problem in health care institutions worldwide. Novel methods to rapidly identify resistances are highly required to ensure an early start of tailored therapy and to prevent further spread of the bacteria. Here, a spectroscopy-based rapid test is presented that reveals resistances of enterococci towards vancomycin within 3.5 hours. Without any specific knowledge on the strain, VRE can be recognized with high accuracy in two different enterococci species. By means of dielectrophoresis, bacteria are directly captured from dilute suspensions, making sample preparation very easy. Raman spectroscopic analysis of the trapped bacteria over a time span of two hours in absence and presence of antibiotics reveals characteristic differences in the molecular response of sensitive as well as resistant Enterococcus faecalis and Enterococcus faecium. Furthermore, the spectroscopic fingerprints provide an indication on the mechanisms of induced resistance in VRE.

  7. 46 CFR 15.1111 - Work hours and rest periods.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Work hours and rest periods. 15.1111 Section 15.1111... REQUIREMENTS Vessels Subject to Requirements of STCW § 15.1111 Work hours and rest periods. (a) Each person... shall receive a minimum of 10 hours of rest in any 24-hour period. (b) The hours of rest required under...

  8. 29 CFR 2530.200b-2 - Hour of service.

    Science.gov (United States)

    2010-07-01

    ... 80 hours of service for his vacation in computation period III (40 hours per week multiplied by 2... would be credited with 80 hours (2 weeks worked multiplied by 40 hours) plus such credit as may be... a payment made or due which is calculated on the basis of units of time, such as hours, days,...

  9. Qualification tests and facilities for the ITER superconductors

    Science.gov (United States)

    Bruzzone, P.; Wesche, R.; Stepanov, B.; Cau, F.; Bagnasco, M.; Calvi, M.; Herzog, R.; Vogel, M.

    2009-06-01

    All the ITER superconductors are tested as short length samples in the SULTAN test facility at CRPP. Twenty-four TF conductor samples with small layout variations were tested since February 2007 with the aim of verifying the design and qualification of the manufacturers. The sample assembly and the measurement techniques at CRPP are discussed. Starting in 2010, another test facility for ITER conductors, named EDIPO, will be operating at CRPP to share with SULTAN the load of the samples for the acceptance tests during the construction of ITER.

  10. Test

    DEFF Research Database (Denmark)

    Bendixen, Carsten

    2014-01-01

    Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers.......Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers....

  11. New opening hours of the gates

    CERN Multimedia

    GS Department

    2009-01-01

    Please note the new opening hours of the gates as well as the intersites tunnel from the 19 May 2009: GATE A 7h - 19h GATE B 24h/24 GATE C 7h - 9h\t17h - 19h GATE D 8h - 12h\t13h - 16h GATE E 7h - 9h\t17h - 19h Prévessin 24h/24 The intersites tunnel will be opened from 7h30 to 18h non stop. GS-SEM Group Infrastructure and General Services Department

  12. Gate A: changes to opening hours

    CERN Multimedia

    2015-01-01

    Due to maintenance work, the opening hours of Gate A (near Reception) will be modified between Monday, 13 and Friday, 17 April 2015.   During this period, the gate will be open to vehicles between 7 a.m. and 9.30 a.m., then between 4.30 p.m. and 7 p.m. It will be completely closed to traffic between 9.30 a.m. and 4.30 p.m. Pedestrians and cyclists may continue to use the gate. We apologise for any inconvenience and thank you for your understanding.

  13. Temporary new opening hours for Gate C

    CERN Document Server

    GS Department

    2010-01-01

    Please note the new temporary opening hours for the gate C as from 22 September 2010 until 29 October 2010 (working days): Morning: between 7:00 a.m. and 9:00 a.m. Lunch: between 12:00 and 2:00 p.m. Evening: between 5:00 pm and 7:00 p.m. Traffic flow will be permitted in both directions during this period. Please minimize your speed accordingly and respect all road signs. GS-SEM Group General Infrastructure Services Department

  14. Electoral (Amendment) (Hours of Polling) Bill 2013

    DEFF Research Database (Denmark)

    Butler, Graham; Hunt, Brian; Doyle, Andrew

    2013-01-01

    Private Members' Bill (legislation) introduced in Dáil Éireann (House of Deputies), Houses of the Oireachtas (Parliament of Ireland). An Act to set voting hours for Dáil Elections, Dáil Bye-Elections, Presidential Elections, European Parliament Elections, Local Government Elections and Referenda...... as being 7.00 a.m. to 10.00 p.m. and for that purpose to amend the Electoral Act 1992, Presidential Elections Act 1993, Referendum Act 1994, European Parliament Elections Act 1997, the Local Government Act 2001 and to provide for related matters....

  15. WordPress 24-hour trainer

    CERN Document Server

    Plumley, George

    2015-01-01

    Create and expand feature-rich sites with no programming experience Ready to build, maintain, and expand your web site with WordPress but have no prior programming experience? WordPress 24-Hour Trainer, 3rd Edition is your book-and-video learning solution that walks you step-by-step through all the important features you will need to know. Lessons range from focused, practical everyday tasks to more advanced, creative features. Learn from an industry professional how to enter content, create pages, manage menus, utilize plug-ins, connect to social media, create membership and e-commerce site

  16. A Comparison of 4- and 24-Hour Urine Samples for the Diagnosis of Proteinuria in Pregnancy

    Directory of Open Access Journals (Sweden)

    Afsane Amirabi

    2011-09-01

    Full Text Available Background: Preeclampsia is a serious complication of pregnancy, and it is vital to diagnosis the condition as early as possible. Proteinuria is an important symptom of preeclampsia, and repeated urine analysis to screen for the condition is part of the standard antenatal care. The purpose of this study was to determine the correlation between 4- and 24-hour urine total protein values to examine whether the 4-hour urine samples could be used for the diagnosis of proteinuria in hypertensive disorders of pregnancy. Methods: A cross-sectional study was performed on 110 pregnant (after gestational week 20 of pregnancy patients who were hypertensive (blood pressure ≥140/90 mmHg and had proteinuria as defined by positive urinary protein of at least 1+ in dipstick. Patients' urine samples were collected over 24 hours; the first 4 hours were collected separately from the next 20-hours. Patients, who did not collect the 24-hour urine, were excluded from the study. One hundred patients met the criteria, and were included in the study. The urine volume, total protein and creatinine levels of 4- and 24-hours samples were measured. The correlation between 4-hour and 24-hour samples was examined using Pearson correlation test. Results: Of the 100 patients, 42 had no proteinuria, 44 had mild proteinuria, and 14 had severe proteinuria. The urine protein values of 4-hour samples correlated with those of the 24-hours samples for patients with mild and severe forms of the disease (P<0.001, r=0.86. Conclusion: This study showed there was a correlation between 4-hour and 24-hour urine proteins. The finding indicates that a random 4-hour sample might be used for the initial assessment of proteinuria

  17. Hour-glass ceilings: Work-hour thresholds, gendered health inequities.

    Science.gov (United States)

    Dinh, Huong; Strazdins, Lyndall; Welsh, Jennifer

    2017-03-01

    Long workhours erode health, which the setting of maximum weekly hours aims to avert. This 48-h limit, and the evidence base to support it, has evolved from a workforce that was largely male, whose time in the labour force was enabled by women's domestic work and care giving. The gender composition of the workforce has now changed, and many women (as well as some men) combine care-giving with paid work, a change viewed as fundamental for gender equality. However, it raises questions on the suitability of the work time limit and the extent it is protective of health. We estimate workhour-mental health thresholds, testing if they vary for men and women due to gendered workloads and constraints on and off the job. Using six waves of data from a nationally representative sample of Australian adults (24-65 years), surveyed in the Household Income Labour Dynamics of Australia Survey (N = 3828 men; 4062 women), our study uses a longitudinal, simultaneous equation approach to address endogeneity. Averaging over the sample, we find an overall threshold of 39 h per week beyond which mental health declines. Separate curves then estimate thresholds for men and women, by high or low care and domestic time constraints, using stratified and pooled samples. We find gendered workhour-health limits (43.5 for men, 38 for women) which widen further once differences in resources on and off the job are considered. Only when time is 'unencumbered' and similar time constraints and contexts are assumed, do gender gaps narrow and thresholds approximate the 48-h limit. Our study reveals limits to contemporary workhour regulation which may be systematically disadvantaging women's health.

  18. 10 CFR 170.20 - Average cost per professional staff-hour.

    Science.gov (United States)

    2010-01-01

    ... Provisions § 170.20 Average cost per professional staff-hour. Fees for permits, licenses, amendments, renewals, special projects, 10 CFR part 55 re-qualification and replacement examinations and tests, other... 10 Energy 2 2010-01-01 2010-01-01 false Average cost per professional staff-hour. 170.20...

  19. Make a movie in 48 hours

    CERN Multimedia

    Brokk Toggerson

    2011-01-01

    This year, the 48-hour film project (48hfp) returns to Geneva after a one-year hiatus. Organized by Neal Hartman and the CERN film-making club, Open Your Eyes Films, the 48hfp challenges teams of film-makers to write, shoot, soundtrack and edit a 4 to 7 minute film in 48 hours from 4 to 6 November.   At the start of the festival, contestants picked their film genre from a hat. The films will be screened on 8 and 9 November, with the awards presentation on the 9th. The winner will receive a trip to the US to compete in the international version of the competition. “There are so many short films being made now," says Hartman, “I think, however, that the 48hfp allows a critical creative mass to form. The result is that these 20 teams make 20 better films than if each participant were making their own." Each team draws a genre from a hat and is given a character, a prop and a line of dialogue that must appear in their film. The genres run the gamut from &am...

  20. Use of short-term (5-Minute) and long-term (18-Hour) leaching tests to characterize, fingerprint, and rank mine-waste material from historical mines in the Deer Creek, Snake River, and Clear Creek Watersheds in and around the Montezuma Mining District, Colorado

    Science.gov (United States)

    Hageman, Philip L.

    2004-01-01

    Precipitation-induced runoff from historical mine-waste located adjacent to the headwaters of the Snake River, Deer Creek, Saints John Creek, Grizzly Gulch, Stevens Gulch, and Leavenworth Creek contributes to the degradation of water quality in these streams. Because historical mine-waste piles have had long-term exposure to the atmosphere, it is surmised that runoff from these piles, induced by meteorological events such as cloudbursts and snowmelt, may cause mobility of acid and metals into a watershed due to dissolution of soluble minerals. For this study, 13 mine-waste composite samples from various mine-wastes in these drainage basins were leached using both a short-term and a long-term leach test. Analytical results from this combination of leach tests are tools that allow the investigator to quantify (fingerprint) which geochemical components could be expected in runoff from these piles if they were leached by a cloudburst (5-minute leach test), as well as what the ?worst-case? geochemical profile would look like if the material were subject to extended leaching and breakdown of the mine-waste material (18-hour leach test). Also, this combination of leach tests allows the geoscientist the ability to see geochemical changes in the mine-waste leachate over time. That is, does the leachate become more or less acidic over time; does the specific conductance increase or decrease; and are there changes in the concentrations of major or trace elements? Further, use of a ranking scheme described herein will aid in prediction of which historical mine-waste piles have the greatest potential for impact on a watershed should runoff occur. Because of long-term weathering of these historical mine-waste piles, geochemical profiles, leachate time-trends, and relative ranking of the mine-wastes produced from analysis of the leachates are Hageman_SIR_2508.doc 1 7/21/2004 2:50 PM indicative of how the mine-waste piles can be expected to act in the environment and may help to

  1. Effect of intraoperatory peritoneal bupivacaine irrigation on inmediate, 24 hour

    Directory of Open Access Journals (Sweden)

    Navarro Hernando

    2004-09-01

    Full Text Available Objective: To compare the response on inmediate, 24 hour abdominal pain and referred shoulder pain (omalgia, when an intraperitoneal irrigation of bupivacaine was used as opposed to saline irrigation, in a group of patients who has laparoscopy done in a medical center in Cali, between April and June of 2000. Material and methods: After previous authorization and consentment by all 100 patients, a placebo was applied to 50 patients and bupivacaine to the other 50 patients, without randomization. The drug came in unmarked bottles, some of which had the medication and some had only saline and nobody knew beforehand which one was given to the patient. Its effect on post surgical pain was evaluated throught the cromatic visual analog scale, which subjectively determines the intensity of the pain according to colors which range from white to dark red, with a numerical equivalent from 0 to 10, in the following manner: zero (0 no pain , 2 mild, 4 moderate, 6 strong, 8 sevre and 10 intolerable pain. The scale was measured in the postoperative room two hours after procedure. A telephonic follow up was done at 24 hours after surgery, applying the visual analog scale on abdominal and shoulder pain. The information was processed using Epi Info 2000. An univariante and bivariante analysis was done. A comparasion was established using the differences in averages with inmediate abdominal pain and omalgia, and at 24 hours according to the use or not bupivacaine. Results: The variable are described in a univariante manner in relation to the distribution of pain at 2 and 24 hours, as well as the shoulder pain, where the mean score of pain decreases from 3.8, to 2.1 to 1.1 respectively. The variables were also described in a bivariant way comparing the drug and its effect on the intensity of pain at 2 and 24 hours, and the omalgia, where no statistically significant difference was found between the drug, the saline and the scales of pain. The relationship between

  2. Aggressive behavior during the first 24 hours of psychiatric admission

    Directory of Open Access Journals (Sweden)

    Vitor Crestani Calegaro

    2014-09-01

    Full Text Available OBJECTIVE: To investigate the association between aggression in the first 24 hours after admission and severity of psychopathology in psychiatric inpatients.METHODS: This cross-sectional study included psychiatric patients admitted to Hospital Universitário de Santa Maria, in Santa Maria, southern Brazil, from August 2012 to January 2013. At their arrival at the hospital, patients were interviewed to fill in the Brief Psychiatric Rating Scale (BPRS form, and any aggressive episodes in the first 24 hours after admission were recorded using the Overt Aggression Scale (OAS. The Mann-Whitney U test was used to compare patients according to aggressiveness: aggressive versus non-aggressive, hostile versus violent, and aggressive against others only versus self-aggressive.RESULTS: The sample was composed of 110 patients. Aggressive patients in general had higher BPRS total scores (p = 0.002 and individual component scores, and their results showed more activation (p < 0.001 and thinking disorders (p = 0.009, but less anxious-depression (p = 0.008. Violent patients had more severe psychomotor agitation (p = 0.027, hallucinations (p = 0.017 and unusual thought content (p = 0.020. Additionally, self-aggressive patients had more disorientation (p = 0.011 and conceptual disorganization (p = 0.007.CONCLUSIONS: Aggression in psychiatric patients in the first 24 hours after admission is associated with severity of psychopathology, and severity increases with severity of patient psychosis and agitation.

  3. NASA 50 amp hour nickel cadmium battery waste heat determination

    Science.gov (United States)

    Mueller, V. C.

    1980-01-01

    A process for determining the waste heat generated in a 50-ampere-hour, nickel cadmium battery as a function of the discharge rate is described and results are discussed. The technique involved is essentially calibration of the battery as a heat transfer rate calorimeter. The tests are run at three different levels of battery activity, one at 40-watts of waste heat generated, one at 60, and one at 100. Battery inefficiency ranges from 14 to 18 percent at discharge rates of 284 to 588 watts, respectively and top-of-cell temperatures of 20 C.

  4. PLANNING OF TRAINING AIRCRAFT FLIGHT HOURS

    Directory of Open Access Journals (Sweden)

    Visnja Vojvodić Rosenzweig

    2010-12-01

    Full Text Available Maintenance of the training aircraft causes downtime of operations and thereby reduces the operational availability, which is crucial for flight planning in a training organisation. Manual daily planning within the fleet delivers suboptimal results and often causes discontinued flight of several aircraft that have to be maintained at the same time. Optimal maintenance schedule of training aircraft can be obtained by a sliding scale method. This paper presents a mathematical model of the sliding scale formulated by a mixed integer linear problem. Allocation of flight hours is optimised by using AMPL programming language, assuring that a sufficient number of aircraft are always available for training. The model can be used by a flight dispatch department in a training organisation as a basis for optimised planning and reduction of maintenance downtime.

  5. CT perfusion imaging and CT subtraction angiography in the diagnosis of ischemic cerebrovascular disease within 24 hours

    Institute of Scientific and Technical Information of China (English)

    管小亭; 于学英; 刘翔; 龙洁; 戴建平

    2003-01-01

    Objective To evaluate the value of the clinical use of CT perfusion imaging (CTPI) and CT subtraction angiography (CTSA) for diagnosing acute ischemic cerebrovascular disease (AICVD). Methods Twenty-four patients with AICVD onset within 24 hours were examined with regular CT, CTPI, and CTSA. Some cases received CTPI, magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), digital subtraction angiography (DSA) or single photon emission computer tomography (SPECT) during follow-up examinations.Results Of the 24 cases, 11 had negative results from regular CT scans 3-6 hours after onset of stroke in 6 cases, 6-12 hours in 3 cases, and 12-24 hours in 2 cases. Ten of these cases were then confirmed by CTPI as having ischemic lesions, 2 with middle cerebral artery occlusion (MCAO), and 1 case with transient ischemic attack (TIA) with CTPI negative. Of the 24 cases, 13 had positive results from regular CT, 9 were diagnosed with ischemic lesions larger by using CTPI than regular CT, 1 case had MCAO and 1 had internal carotid artery occlusion (ICAO). There were 4 cases with ischemic lesions observed with regular CT having nearly the same range as that of lacunar infarctions using CTPI. Another 4 cases had more than 2 lesion areas. The peak time (PT), mean transit time (MTT) and relative flow (RF) of 24 cases were markedly different. The sides of ischemic lesions compared to each other and the core of the lesion compared to peripheral zones were also altered significantly (P<0.01).Conclusions Combined CTPI with CTSA can detect acute ischemic lesions at early and hyper-early stages and could distinguish between TIA, lacunar infarction and a larger area of infarction. Using semiquantitative blood perfusion analysis status, CTPI with CTSA could define position, area and range of the ischemic lesion and penumbra. These scans can also analyze the brain blood perfusion status. It is important to early diagnose the occlusion of the entire division of the internal

  6. Performance Sustainment of Two Man Crews during 87 Hours of Extended Wakefulness with Stimulants and Napping

    Science.gov (United States)

    2009-02-01

    Repeated Test of Sustained Wakefulness (RTSW) .........................................................17  Polysomnography (PSG...N ap 19 Polysomnography (PSG) Nap Effects. A 2-hour nap was provided to determine its effects on restoring performance. During this nap, PSG

  7. 24 hours on-call and acute fatigue no longer worsen resident mood under the 80-hour work week regulations.

    Science.gov (United States)

    Kiernan, Michael; Civetta, Joseph; Bartus, Christine; Walsh, Stephen

    2006-01-01

    Studies in on-call residents have shown that mood is worsened by fatigue as indicated by increased scores on measures of depression, anxiety, confusion, and anger using the Profile of Mood States (POMS). In prior sleep deprivation studies, mood has been shown to be more affected than either cognitive or motor performances. The purpose of this study was to examine the effect of the 80-hour work week regulations on resident mood in general and in a post-call period (PC). Institutional Review Board approval was obtained to survey the residents and publish the results. POMS is a 65-item adjective questionnaire that includes subscales for measuring tension-anxiety, anger-hostility, depression-dejection, vigor-activity, fatigue-inertia, and confusion-bewilderment, with the summation of the scales forming a total mood disturbance score. Surgical residents were tested at a 9 am didactic curriculum session (9 am has been shown to correlate with the nadir of performance). Residents were tested after nights off call (NOC) or after PC. Time asleep in the preceding 24 hours and other demographic data were also collected. Acute fatigue (AF) was defined as mood questionnaires were administered on 4 occasions to 51 surgical residents, 35 men and 16 women at levels PGY-1 through PGY-5. Overall, 33 tests (27%) were taken after PC and 90 (73%) were taken after NOC. Acute fatigue residents had a mean sleep time of 2.2 (+/-1.5) hours, whereas rested (R) residents had a mean sleep time of 6.7 (+/-2.2) hours (whether PC or NOC). No statistical differences in mean values of vigor, anger, depression, concentration, fatigue, tension, or total score were observed between PC and NOC or between AF and R residents. There was no significant relationship between acute sleep deprivation and total mood disturbance, whether PC or NOC. In linear relationships, NOC total score and hours slept had r2 = 0.01 (p = 0.44), whereas PC total score and hours slept had r2 = 0.07 (p = 0.14). Although POMS was

  8. One-hour blood xylose in the diagnosis of cows' milk protein-sensitive enteropathy.

    OpenAIRE

    Iyngkaran, N; Abidin, Z.

    1982-01-01

    The 1-hour xylose absorption test was evaluated as method for the diagnosis of cows' milk protein-sensitive enteropathy in a prospective study of 48 infants with diarrhoea clinically suspected to be due to intolerance of cows' milk. The infants were maintained on a lactose and cows milk protein-free diet for 6-8 weeks and then were challenged with cows' milk protein. Jejunal biopsies and the 1-hour xylose absorption test were performed immediately before and 20-24 hours after cows' milk provo...

  9. Hourly Calculation Method of Air Source Heat Pump Behavior

    Directory of Open Access Journals (Sweden)

    Ludovico Danza

    2016-04-01

    Full Text Available The paper describes an hourly simplified model for the evaluation of the energy performance of heat pumps in cooling mode maintaining a high accuracy and low computational cost. This approach differs from the methods used for the assessment of the overall energy consumption of the building, normally placed in the so-called white or black box models, where the transient conduction equation is deterministically and stochastically solved, respectively. The present method wants to be the expression of the grey box model, taking place between the previous approaches. The building envelope is defined using a building thermal model realized with a 3 Resistance 1 Capacitance (3R1C thermal network based on the solution of the lumped capacitance method. The simplified model evaluates the energy efficiency ratio (EER of a heat pump through the determination of the hourly second law efficiency of a reversed Carnot cycle. The results of the simplified method were finally compared with those provided by EnergyPlus, a dynamic building energy simulation program, and those collected from an outdoor test cell in real working conditions. The results are presented in temperatures and energy consumptions profiles and are validated using the Bland-Altman test.

  10. 24-hour urinary aldosterone excretion rate

    Science.gov (United States)

    ... Laxative abuse Lower than normal levels may indicate Addison disease . Risks There are no risks with this test. ... and the A.D.A.M. Editorial team. Addison Disease Read more Adrenal Gland Disorders Read more Latest ...

  11. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours.

    Science.gov (United States)

    Seeram, Navindra P; Henning, Susanne M; Zhang, Yanjun; Suchard, Marc; Li, Zhaoping; Heber, David

    2006-10-01

    Ellagitannins (ETs) from pomegranate juice (PJ) are reported to have numerous biological properties, but their absorption and metabolism in humans are poorly understood. To investigate the pharmacokinetics of pomegranate ETs, 18 healthy volunteers were given 180 mL of PJ concentrate, and blood samples were obtained for 6 h afterwards. Twenty-four-hour urine collections were obtained on the day before (-1), the day of (0), and the day after (+1) the study. Ellagic acid (EA) was detected in plasma of all subjects with a maximum concentration of 0.06 +/- 0.01 micromol/L, area under concentration time curve of 0.17 +/- 0.02 (micromol x h) x L(-1), time of maximum concentration of 0.98 +/- 0.06 h, and elimination half-life of 0.71 +/- 0.08 h. EA metabolites, including dimethylellagic acid glucuronide (DMEAG) and hydroxy-6H-benzopyran-6-one derivatives (urolithins), were also detected in plasma and urine in conjugated and free forms. DMEAG was found in the urine obtained from 15 of 18 subjects on d 0, but was not detected on d -1 or +1, demonstrating its potential as a biomarker of intake. Urolithin A-glucuronide was found in urine samples from 11 subjects on d 0 and in the urine from 16 subjects on d +1. Urolithin B-glucuronide was found in the urine of 3 subjects on d 0 and in the urine of 5 subjects on d +1. Urolithins, formed by intestinal bacteria, may contribute to the biological effects of PJ as they may persist in plasma and tissues and account for some of the health benefits noted after chronic PJ consumption. Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established.

  12. THE EFFECTS OF 30 HOURS SLEEP DEPRIVATION ON BASIC FOOTBALL SKILLS OF SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Mehrdad Hefzollesan

    2012-08-01

    Full Text Available The aim of this study is to determine the effect of sleep deprivation on the passing and shooting skills of football players. To this end, 18 students of Sahand University, with age range 20 to 24 years performed basic soccer skills (shoot and pass in the pre-test and post test stages. In this study to assess these skills, the test "Mor - Christian" has been used. In the first step, subjects conducted the shoot and pass test as pre-test after 8 hours sleep a night. 10 days later, to ensure the validity of tests and test results on the learning effect, subjects did the same test again after 8 hours sleep a night. In the third stage, 30 hours of sleep deprivation as an independent variable imposed on the subjects and then the test was repeated and experimental test results were compared as recorded using paired t-test. The findings showed that 30 hour sleep deprivation decreases passing and shooting skills implementation skills (p <0.001. Therefore, the findings showed that sleep deprivation can be a devastating effect on basic football skills.

  13. THE EFFECT OF 36 HOURS SLEEP DEPRIVATION ON DRIBBLING SKILLS OF SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Mehrdad Hefzollesan

    2013-08-01

    Full Text Available The aim of this study is to determine the effect of sleep deprivation on the dribbling skills of football players. To this end, 22 students of Sahand University, with age range (20-24 years performed dribbling skill in the pre-test and post test stages. In this study to assess this skill, the test "Mor - Christian" has been used. In the first step, subjects conducted the dribble test as pre-test after 8 hours sleep a night. 10 days later, to ensure the validity of tests and test results on the learning effect, subjects did the same test again after 8 hours sleep a night. In the third stage, 36 hours of sleep deprivation as an independent variable imposed on the subjects and then the test was repeated and experimental test results were compared as recorded using paired t-test. The findings showed that 36 hour sleep deprivation decreases dribble implementation skills (p <0.001. Therefore, the findings showed that sleep deprivation can be a devastating effect on dribbling skill.

  14. Beta-carotene blood test

    Science.gov (United States)

    Carotene test ... anything for up to 8 hours before the test. You may also be asked not to eat ... vitamin A (carotene) for 48 hours before the test. Your provider may also tell you to temporarily ...

  15. CMAQv502 Base AQS Hourly site compare output

    Data.gov (United States)

    U.S. Environmental Protection Agency — Monthly AQS hourly site compare output files for the CMAQv502 Base simulation. Monthly files contain hourly paired model/ob data for the AQS network. These data were...

  16. Rush Hour Pollution May Be Worse Than Thought

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_167478.html Rush Hour Pollution May Be Worse Than Thought Higher measurements seen ... in rush-hour traffic? New research finds air pollution levels in cars are much higher than previously ...

  17. [How does sleep deprivation during 24 hours on call duty affect the cognitive performance orthopaedic residents?].

    Science.gov (United States)

    Albergo, J I; Fernández, M C; Zaifrani, L; Giunta, D H; Albergo, L

    2016-01-01

    Sleep deprivation is usually present in residents during their training program. The purpose of our study was to analyze the cognitive performance of a group of orthopaedic residents before and after 24 hours on call duty. We include orthopaedic residents and their cognitive functions were evaluated by the following tests: Continuous Performance Test (CPT 2), Digit Spam (Versión 5), 1 letter Fonologic Fluence y Pasat Test. All the tests were done after a sleeping period at home of at least 6 hours and after being on call (sleeping less than 3 hours). Nineteen residents were included in the study. The median age was 27 ± 1.89 and 15 were male. The mean hours of sleeping at home was 6.5 (range 6-8) and after on call duty was 1.5 (range 0.5-3). Statistical difference were found in CPT 2 test en terms of correct answers (p=0.007), omissions (p=0.004) and perseverations (p=0.036). No significant differences were found in the other tests. Sleep deprivation after 24 hours on call duty affects cognitive performance of orthopaedic residents, increasing the number of errors and omissions. Copyright © 2015 SECOT. Published by Elsevier Espana. All rights reserved.

  18. A vascular laboratory protocol for improving and managing after-hours suspected acute deep venous thrombosis.

    Science.gov (United States)

    Martin, Angela H; Eckert, George; Lemmon, Gary W; Sawchuk, Alan; Dalsing, Michael C

    2014-04-01

    This study reviews the clinical and workforce impact of a suggested protocol designed for the management of suspected acute deep venous thrombosis (DVT) in patients seen after standard vascular laboratory business hours. The protocol included the use of Wells score, D-dimer and a single dose of therapeutic anticoagulant to defer venous duplex ultrasound (VDU) testing until routine business hours unless contraindicated. Information was collected on medical history, physical exam and the timing of any diagnostic studies and treatment provided. Over 15% of studies done after-hours were deemed unnecessary by our protocol and in every individual the results were negative for an acute DVT. There were no adverse events from a one-time dose of anticoagulant. Limiting emergency VDU coverage to evaluate for acute DVT based on a management protocol can eliminate unnecessary after-hours VDU testing without having a negative impact on patient care.

  19. 19 CFR 101.6 - Hours of business.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Hours of business. 101.6 Section 101.6 Customs... GENERAL PROVISIONS § 101.6 Hours of business. Except as specified in paragraphs (a) through (g) of this section, each CBP office shall be open for the transactions of general CBP business between the hours of 8...

  20. Resident Duty Hours: Enhancing Sleep, Supervision, and Safety

    Science.gov (United States)

    Ulmer, Cheryl, Ed.; Wolman, Dianne Miller, Ed.; Johns, Michael M. E., Ed.

    2009-01-01

    Medical residents in hospitals are often required to be on duty for long hours. In 2003 the organization overseeing graduate medical education adopted common program requirements to restrict resident workweeks, including limits to an average of 80 hours over 4 weeks and the longest consecutive period of work to 30 hours in order to protect…

  1. "Hour of Code": Can It Change Students' Attitudes toward Programming?

    Science.gov (United States)

    Du, Jie; Wimmer, Hayden; Rada, Roy

    2016-01-01

    The Hour of Code is a one-hour introduction to computer science organized by Code.org, a non-profit dedicated to expanding participation in computer science. This study investigated the impact of the Hour of Code on students' attitudes towards computer programming and their knowledge of programming. A sample of undergraduate students from two…

  2. Hourly Electricity Prices in Day-Ahead Markets

    NARCIS (Netherlands)

    R. Huisman (Ronald); C. Huurman; R.J. Mahieu (Ronald)

    2007-01-01

    textabstractThis paper focuses on the characteristics of hourly electricity prices in day-ahead markets. In these markets, quotes for day-ahead delivery of electricity are submitted simultaneously for all hours in the next day. The same information set is used for quoting all hours of the day. The d

  3. 48 CFR 16.602 - Labor-hour contracts.

    Science.gov (United States)

    2010-10-01

    ... METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 16.602 Labor-hour contracts. Description. A labor-hour contract is a variation of the time-and-materials contract, differing only in that materials are not supplied by the contractor. See 12.207(b),...

  4. Growth hormone stimulation test

    Science.gov (United States)

    Arginine test; Arginine-GHRH test ... of re-inserting the needle each time. The test takes between 2 to 5 hours. The procedure ... eat for 10 to 12 hours before the test. Eating food can change the test results. Some ...

  5. Recuperação da freqüência cardíaca após teste de esforço em esteira ergométrica e variabilidade da freqüência cardíaca em 24 horas em indivíduos sadios Heart rate recovery after treadmill electrocardiographic exercise stress test and 24-hour heart rate variability in healthy individuals

    Directory of Open Access Journals (Sweden)

    Ivana Antelmi

    2008-06-01

    Full Text Available FUNDAMENTO: A recuperação da freqüência cardíaca após o eletrocardiograma de esforço em esteira ergométrica é modulada pelo sistema nervoso autônomo. A análise da variabilidade da freqüência cardíaca (VFC pode fornecer informações valiosas sobre o controle do sistema nervoso autônomo sobre o sistema cardiovascular. OBJETIVO: O objetivo deste estudo foi testar a hipótese de associação entre a recuperação da freqüência cardíaca após teste de esforço em esteira ergométrica e a variabilidade da freqüência cardíaca. MÉTODOS: Foram estudamos 485 indivíduos sem evidência de cardiopatia com média de idade de 42± 12,1 (faixa etária de 15 a 82 anos, 281 (57.9% dos quais do sexo feminino, submetidos a um teste de esforço em esteira ergométrica e avaliação da VFC nos domínios do tempo (SDNN, SDANN, SDNNi, rMSSD e pNN50 e da freqüência (LF, HF, VLF e razão LF/HF durante monitoramento eletrocardiográfico ambulatorial de 24 horas. RESULTADOS: A recuperação da freqüência cardíaca foi de 30 ± 12 batimentos no 1º minuto e 52± 13 batimentos no 2º minuto após o exercício. Os indivíduos mais jovens de recuperaram mais rápido do 2º ao 5º minuto após o exercício (r = 0,19-0,35, P BACKGROUND: Heart rate recovery after treadmill electrocardiographic exercise stress test is modulated by the autonomic nervous system. Analysis of heart rate variability can provide useful information about autonomic control of the cardiovascular system. OBJECTIVE: The aim of the study was to test the hypothesis of association between heart recovery after treadmill electrocardiographic exercise test and heart rate variability. METHODS: We studied 485 healthy individuals aged 42± 12.1 (range 15-82 years, 281(57.9% women, submitted to treadmill electrocardiographic exercise stress tests and heart rate variability evaluations over time (SDNN, SDANN, SDNNi, rMSSD, pNN50 and frequency (LF, HF, VLF, LF/HF ratio domains in 24-hour

  6. [Systematic implementation of transthoracic echocardiography, transesophageal echocardiography and 24-hour Holter ECG for the detection of cardiac sources of embolism in patients with stroke or transient ischemic attack. A retrospective study of 220 patients].

    Science.gov (United States)

    Vinsonneau, U; Leblanc, A; Buchet, J-F; Pangnarind-Heintz, V; Le Gal, G; Rohel, G; Paleiron, N; Piquemal, M; Blanchard, C; Zagnoli, F; Paule, P

    2014-09-01

    Embolism of cardiac origin accounts for around 20% of ischemic strokes. ECG and transthoracic echocardiography (TTE) are commonly obtained during the evaluation of patient of ischemic stroke but specific indications for the transesophageal (TEE) echocardiography and 24-hour Holter ECG (Holter) remain uncertain. The aim of this study is to report the contribution of TTE, TEE and Holter performed as a routine during the evaluation of patients with ischemic stroke (IS) or transient ischemic attack (TIA). This is a retrospective single-center study of 220 patients hospitalized between 1st January 2007 and 31st December 2010 for a first IS or TIA. One hundred and forty-three IS and 77 TIA are identified. The average age of patients was 66 years (18-88 years). TTE/TEE/24-hour Holter allowed the diagnosis of cardiac sources of embolism in 135 patents (61.3%). TTE/TEE identified potential source of cardiogenic embolism in 126 patients (52.2%). Twenty four-hour Holter ECG tracked supraventricular arrhythmia in 15 patients (6.7%), 9 (4%) which had non-contributory ultrasound assessment. The systematic implementation of TTE/TEE/Holter is useful for identifying potential sources of cardiogenic embolism. The performance of TEE remains above the TTE. Holter should be recommended because it is a cost effective and non-invasive tool. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  7. Stress relaxation properties of four orthodontic aligner materials: A 24-hour in vitro study.

    Science.gov (United States)

    Lombardo, Luca; Martines, Elisa; Mazzanti, Valentina; Arreghini, Angela; Mollica, Francesco; Siciliani, Giuseppe

    2017-01-01

    To investigate the stress release properties of four thermoplastic materials used to make orthodontic aligners when subjected to 24 consecutive hours of deflection. Four types of aligner materials (two single and two double layered) were selected. After initial yield strength testing to characterize the materials, each sample was subjected to a constant load for 24 hours in a moist, temperature-regulated environment, and the stress release over time was measured. The test was performed three times on each type of material. All polymers analyzed released a significant amount of stress during the 24-hour period. Stress release was greater during the first 8 hours, reaching a plateau that generally remained constant. The single-layer materials, F22 Aligner polyurethane (Sweden & Martina, Due Carrare, Padova, Italy) and Duran polyethylene terephthalate glycol-modified (SCHEU, Iserlohn, Germany), exhibited the greatest values for both absolute stress and stress decay speed. The double-layer materials, Erkoloc-Pro (Erkodent, Pfalzgrafenweiler, Germany) and Durasoft (SCHEU), exhibited very constant stress release, but at absolute values up to four times lower than the single-layer samples tested. Orthodontic aligner performance is strongly influenced by the material of their construction. Stress release, which may exceed 50% of the initial stress value in the early hours of wear, may cause significant changes in the behavior of the polymers at 24 hours from the application of orthodontic loads, which may influence programmed tooth movement.

  8. Inflight Exercise Regimen for the 2-Hour Prebreathe Protocol

    Science.gov (United States)

    Foster, Philip P.; Gernhardt, Michael L.; Woodruff, Kristin K.; Schneider, Susan M.; Homick, Jerry L. (Technical Monitor)

    2000-01-01

    A 10 min aerobic prebreathe exercise up to 75% V-O2(sub max) on a dual-cycle ergometer, included in the 2-hour prebreathe protocol, has been shown to dramatically reduce the incidence of decompression sickness (DCS) at altitude. In-flight only leg ergometry will be available. A balanced exercise was developed using surgical tubing with the ergometer on-orbit. We hypothesize that a 75% V02max workload, individually prescribed, would be achieved using a target heart rate to regulate the intensity of the arm exercise. VO2, heart rate (HR) / ECG, V-CO2 /V-O2, V(sub E), and V(sub T), and rate of perceived exertion (Borg scale) were measured in eleven healthy subjects who passed a US Air Force Class III Physical examination. A V-O2 peak test was performed to assess the sub-maximal exercise prescription. Two series of sub-maximal tests were performed: (1) leg ergometer/hand ergometer and (2) leg ergometer/surgical tubes. We found no significant differences (P > 0.05) in comparing the means for V-O2 and HR between the predicted and measured values during the final 4 minute-stage at "75% V-O2 workload" or between the two types of sub-maximal tests. The prescribed prebreathe sub-maximal exercise performed with flight certified surgical tubes was achieved using the target HR.

  9. 2,445 Hours of Code: What I Learned from Facilitating Hour of Code Events in High School Libraries

    Science.gov (United States)

    Colby, Jennifer

    2015-01-01

    This article describes a school librarian's experience with initiating an Hour of Code event for her school's student body. Hadi Partovi of Code.org conceived the Hour of Code "to get ten million students to try one hour of computer science" (Partovi, 2013a), which is implemented during Computer Science Education Week with a goal of…

  10. Activity of Euphorbia splendens var. hislopii N.E.B. (Euphorbiaceae) latex against Lymnaea columella (Say, 1817) (Pulmonata: Lymnaeidae), intermediate host of Fasciola hepatica, Linnaeus, 1758 (Trematoda: Fasciolidae). 2: limited field-testing.

    Science.gov (United States)

    de Vasconcellos, Mauricio Carvalho; de Amorim, Alziro

    2003-10-01

    The molluscicidal evaluation of Euphorbia splendens var. hislopii (Crown of thorns) against Lymnaea columella snails, intermediate host of Fasciola hepatica, in irrigation ditches of the Pisciculture Station at Universidade Federal Rural do Rio de Janeiro, was studied under limited field conditions. An aqueous solution of the latex at 5 mg/l was tested in two irrigation ditches (experimental and control ditches), after initial sampling of the snail population present. Twenty-four hours after application of the product, it was verified that 97.4% of free L. columella snails and 100% of snails of the same species captive in cages and used as sentinels at three points equidistant from the application site in the experimental ditch, died. For Biomphalaria tenagophila and Melanoides tuberculata snails, present in the experimental ditch, the mortality was 100%, for the species Pomacea spp. the mortality was 40%. No mortality was verified in the free mollusks, or in the sentinels in the ditch used as control. E. splendens var. hislopii latex is thus an efficient natural molluscicide, which may be used as an alternative control agent against L. columella.

  11. Activity of Euphorbia splendens var. hislopii N.E.B. (Euphorbiaceae latex against Lymnaea columella (Say, 1817 (Pulmonata: Lymnaeidae, intermediate host of Fasciola hepatica, Linnaeus, 1758 (Trematoda: Fasciolidae. 2: limited field-testing

    Directory of Open Access Journals (Sweden)

    Vasconcellos Mauricio Carvalho de

    2003-01-01

    Full Text Available The molluscicidal evaluation of Euphorbia splendens var. hislopii (Crown of thorns against Lymnaea columella snails, intermediate host of Fasciola hepatica, in irrigation ditches of the Pisciculture Station at Universidade Federal Rural do Rio de Janeiro, was studied under limited field conditions. An aqueous solution of the latex at 5 mg/l was tested in two irrigation ditches (experimental and control ditches, after initial sampling of the snail population present. Twenty-four hours after application of the product, it was verified that 97.4% of free L. columella snails and 100% of snails of the same species captive in cages and used as sentinels at three points equidistant from the application site in the experimental ditch, died. For Biomphalaria tenagophila and Melanoides tuberculata snails, present in the experimental ditch, the mortality was 100%, for the species Pomacea spp. the mortality was 40%. No mortality was verified in the free mollusks, or in the sentinels in the ditch used as control. E. splendens var. hislopii latex is thus an efficient natural molluscicide, which may be used as an alternative control agent against L. columella.

  12. THE EFFECT OF 36 HOURS SLEEP DEPRIVATION ON DRIBBLING SKILLS OF SOCCER PLAYERS

    OpenAIRE

    2013-01-01

    The aim of this study is to determine the effect of sleep deprivation on the dribbling skills of football players. To this end, 22 students of Sahand University, with age range (20-24 years) performed dribbling skill in the pre-test and post test stages. In this study to assess this skill, the test "Mor - Christian" has been used. In the first step, subjects conducted the dribble test as pre-test after 8 hours sleep a night. 10 days later, to ensure the validity of tests and test results on t...

  13. Randomized clinical trial between hourly titrated and 2 hourly static oral misoprostol solution for induction of labor.

    Science.gov (United States)

    Rouzi, Abdulrahim A; Alsahly, Nora; Alamoudi, Rana; Almansouri, Nisma; Alsinani, Nawal; Alkafy, Souzan; Rozzah, Rayyan; Abduljabbar, Hassan

    2017-04-01

    Misoprostol is an effective agent for the induction of labor. Existing guidelines recommend oral misoprostol solution 25 μg every 2 hours. However, more research is required to optimize the use of oral misoprostol solution for the induction of labor. The purpose of this study was to compare efficacy and safety of hourly titrated-dose oral misoprostol solution with static-dose oral misoprostol solution every 2 hours for labor induction. In this randomized controlled study, oral misoprostol solution was administered as (1) 20 μg hourly (≤4 doses) that was increased in the absence of regular uterine contractions to 40 μg hourly (≤4 doses) and then to 60 μg hourly (≤16 doses) or (2) 25 μg every 2 hours until active labor began (≤12 doses). A sample size of 146 women was planned with the use of a projected 95% rate for the primary endpoint (vaginal delivery within 24 hours) for hourly titrated-dose misoprostol and 80% rate for static-dose misoprostol every 2 hours. Safety outcomes included maternal morbidity and adverse neonatal outcomes. From December 2013 to July 2015, 146 women were assigned randomly to treatment. Demographic and clinical factors were similar between groups, except for age. Vaginal delivery was achieved within 24 hours in 47 women (64.4%) who received hourly titrated-doses of misoprostol solution and 48 women (65.8%) who received 2-hourly static-dose misoprostol solution (P=1.00). Rates of vaginal delivery within 24 hours did not differ significantly between treatment groups for women who were nulliparous (P=1.00) or who had postterm pregnancies (P=.66), a Bishop score of ≤3 (P=.84), or oxytocin augmentation (P=.83). Cesarean deliveries were performed within 24 hours in 9 women who received hourly titrated-dose misoprostol solution and 2 women who received 2-hourly static-dose misoprostol solution (P=.056). Pyrexia and meconium-stained liquor occurred more frequently with the hourly titrated-dose regimen. The static-dose oral

  14. [Fluctuation of intraocular pressure in 24-hour telemonitoring compared to tonometry during normal office hours].

    Science.gov (United States)

    Jürgens, C; Antal, S; Henrici, K; Grossjohann, R; Tost, F H

    2009-01-01

    Elevated intraocular pressure (IOP) is a clinically relevant factor in glaucoma progression. As a dynamic parameter the IOP depends on various internal and exogenic influencing factors. Therefore, we analysed intraindividual IOD variations between ambulant care and 24-h home-monitoring using self-tonometry. This study is based on paper-based glaucoma cards of 25 patients with primary open angle glaucoma. Additionally, all patients participated in a telemedical home-monitoring study with self-measurements of IOP and blood pressure stored in an electronic patient record. The glaucoma cards contained a total number of 409 IOP values with documentation periods from 0.5 to 10 years. In the teletonometry project all 25 patients were observed for 6 months with 1490 recorded IOP values. Statistical analysis was performed with SPSS software. Average IOP values for all 25 glaucoma patients were 16.3 +/- 2.9 mmHg for both eyes in glaucoma card documentation, whereas the electronic patient records showed IOP averages of 18.9 +/- 4.7 mmHg for right eyes and 18.2 +/- 4.4 mmHg for left eyes. Corresponding to the practice opening hours the glaucoma cards contained no IOP records from 12:00 pm to 01:30 pm as well as between 06:00 pm and 07:15 am. In these time periods 17 % of all IOP values recorded in 24-hour teletonometry were higher than 20 mmHg. However, statistical analysis and clinical evaluation of device parameters and measurement characteristics revealed sporadic measuring errors. The additional involvement of self-tonometry in telemedical 24-h home-monitoring is a feasible method to record and detect intraday IOP fluctuations. Compared to single IOP measurements documented in common paper-based glaucoma cards, the 24-h electronic patient record showed more frequent circadian IOP variations. As a result, self-tonometry and home-monitoring can be a useful link to fill the gap between singular ambulant IOP measurement and hospitalisation with 24-hour IOP profiles.

  15. Flexible work in call centres: Working hours, work-life conflict & health.

    Science.gov (United States)

    Bohle, Philip; Willaby, Harold; Quinlan, Michael; McNamara, Maria

    2011-01-01

    Call-centre workers encounter major psychosocial pressures, including high work intensity and undesirable working hours. Little is known, however, about whether these pressures vary with employment status and how they affect work-life conflict and health. Questionnaire data were collected from 179 telephone operators in Sydney, Australia, of whom 124 (69.3%) were female and 54 (30.2%) were male. Ninety-three (52%) were permanent full-time workers, 37 (20.7%) were permanent part-time, and 49 (27.4%) were casual employees. Hypothesised structural relationships between employment status, working hours and work organisation, work-life conflict and health were tested using partial least squares modelling in PLS (Chin, 1998). The final model demonstrated satisfactory fit. It supported important elements of the hypothesised structure, although four of the proposed paths failed to reach significance and the fit was enhanced by adding a path. The final model indicated that casual workers reported more variable working hours which were relatively weakly associated with greater dissatisfaction with hours. The interaction of schedule control and variability of hours also predicted dissatisfaction with hours. Conversely, permanent workers reported greater work intensity, which was associated with both lower work schedule control and greater work-life conflict. Greater work-life conflict was associated with more fatigue and psychological symptoms. Labour market factors and the undesirability of longer hours in a stressful, high-intensity work environment appear to have contributed to the results.

  16. A novel diversion protocol dramatically reduces diversion hours.

    Science.gov (United States)

    Asamoah, Osei Kwame; Weiss, Steven J; Ernst, Amy A; Richards, Michael; Sklar, David P

    2008-07-01

    Ambulance diversion is a problem in many communities. When patients are diverted prompt and appropriate medical care may be delayed. Compare diversion hours and drop-off times before and after a dramatic change in diversion policy restricting each hospital to 1 hour out of every 8. This study was a retrospective study in a county of 600,000 people and 10 hospitals from September 2004 to February 2006. A countywide diversion protocol was implemented in March 2005 that limited diversion hours to 1 hour out of every 8 (maximum of 90 h/mo). No other changes were implemented during the study period. Pretrial (9/04-2/05), interim (3/05-8/05), and posttrial (9/05-2/06) periods were compared. The main outcome measures were ambulance diversion hours and emergency medical service (EMS) drop-off times. Results were compared using analysis of variance and a Tukey post hoc analysis. P ambulance diversion hours (difference, 251 hours; 95% CI, 136-368) and significant increase in additional time that EMS crews required to transport patients (drop-off times) (difference, 178 hours; 95% CI, 74-283) were observed. Posttrial diversion hours decreased to 18% of the pretrial values (from 305 to 54). This novel ambulance diversion protocol dramatically reduced diversion hours at the cost of increasing EMS drop-off times in a large community.

  17. Preparation and results of a 24-hour orbital flight.

    Science.gov (United States)

    Titov, G S

    1963-01-01

    The space age presents man with unprecedented opportunities for discovery and for cooperative endeavors to benefit all mankind. My flight of August 6-7, 1961 was conducted for the purpose of determining whether man can stay and work effectively and whether all systems of the spaceship can operate successfully during a period of 24 hours in space. The flight of Vostok II represents an experimental step in a logical sequence which included the first earth orbiting flight of USSR citizen Yuri A. Gagarin. Preparation for the flight included the study of theoretical and applied subjects, testing in various kinds of apparatus which provide acceleration, heat and isolation experience, brief airborne weightless flights and parachute landings, in addition to extensive training in a real spacecraft having simulators for normal and emergency contingencies of space flight. The actual flight was therefore carried out with a sense of confidence and familiarity and with continuous close radio contact with ground centers from whom my fellow cosmonauts served as spokesmen. Sequential boosters totaling 600 000 kg thrust placed the 4731 kg spaceship into a perfect orbit varying in altitude from 178-246 km in a plane 64 degrees 58' inclined to the equator. The spaceship made 17 orbits around the earth landing 25 hours, 18 minutes after take-off. The cabin had full atmospheric pressure and a comfortable habitability which could be extended for 10 days. I was able to maneuver the spaceship and perform many other control functions, make observations and take pictures of the earth and its cloud cover, eat meals and sleep all with good efficiency. I experienced mild symptoms suggestive of seasickness which were aggravated by head turning, ameliorated by sleep and entirely relieved by resumption of g-loading during descent. Altogether analyses of the physical and structural performance of the spaceship and the continuously monitored physiological responses of the pilot indicate that all

  18. Cognitive Performance during a 24-Hour Cold Exposure Survival Simulation

    Directory of Open Access Journals (Sweden)

    Michael J. Taber

    2016-01-01

    Full Text Available Survivor of a ship ground in polar regions may have to wait more than five days before being rescued. Therefore, the purpose of this study was to explore cognitive performance during prolonged cold exposure. Core temperature (Tc and cognitive test battery (CTB performance data were collected from eight participants during 24 hours of cold exposure (7.5°C ambient air temperature. Participants (recruited from those who have regular occupational exposure to cold were instructed that they could freely engage in minimal exercise that was perceived to maintaining a tolerable level of thermal comfort. Despite the active engagement, test conditions were sufficient to significantly decrease Tc after exposure and to eliminate the typical 0.5–1.0°C circadian rise and drop in core temperature throughout a 24 h cycle. Results showed minimal changes in CTB performance regardless of exposure time. Based on the results, it is recommended that survivors who are waiting for rescue should be encouraged to engage in mild physical activity, which could have the benefit of maintaining metabolic heat production, improve motivation, and act as a distractor from cold discomfort. This recommendation should be taken into consideration during future research and when considering guidelines for mandatory survival equipment regarding cognitive performance.

  19. Working 61 plus hours a week: why do managers do it?

    Science.gov (United States)

    Brett, Jeanne M; Stroh, Linda K

    2003-02-01

    The authors investigated why some managers work extreme hours, defined as 61 or more hours per week. The authors tested explanations drawn from theories including the work-leisure tradeoff, work as an emotional respite, social contagion, and work as its own reward. In a demographically homogeneous sample of male managers, the best explanations for why some worked 61 or more hours per week were the financial and psychological rewards they received from doing so. The hypothesis derived from A. Hochschild's (1997) research that managers who work long hours seek relief at work from pressures at home was not supported. Findings in a small sample of managerial women were consistent with the work-leisure trade-off hypothesis, the social contagion hypothesis, and the work as its own reward hypothesis.

  20. The evaluation of TF-Test kit for diagnosis of gastrointestinal parasite infections in sheep

    OpenAIRE

    Lumina,Giuliano; Bricarello,Patrizia Ana; GOMES, Jancarlo Ferreira; do Amarante, Alessandro Francisco Talamini [UNESP

    2006-01-01

    This study was performed to standardize parasite egg counting in feces of sheep by TF-Test, in addition to compare this test to the Gordon & Whitlock technique (G&W). Twenty-four lambs were artificially infected with Haemonchus contortus throughout 12 weeks. At the end of this time, faecal samples were taken and animals were slaughtered for worm identification and counting. G&W and TF-Test methods were carried out on each fecal sample. Both tests showed Haemonchus eggs in 95.8% of the samples...

  1. Interns shall not sleep: the duty hours boomerang

    Directory of Open Access Journals (Sweden)

    Quan SF

    2017-04-01

    Full Text Available No abstract available. Article truncated after 150 words. On March 10, 2017, the Accreditation Council for Graduate Medical Education (ACGME announced revisions to its common program requirements related to duty hours (1. Effective on July 1, 2017, the most important change will be an increase in the maximum consecutive hours that an intern may work. Interns will now be able to continuously perform patient care work up to a maximum of 24 hours with an additional 4 hours for managing care transitions. This reverses the controversial reduction to 16 hours that occurred in 2011 (2. The regulation of house staff duty hours formally began in the late 1980s. It was precipitated largely because of the publicity resulting from the 1984 death of Libby Zion in a New York teaching hospital that was attributed partly to poor decisions made by fatigued and overworked house staff (3. Consequently, the state of New York in 1989 passed laws restricting the …

  2. “Friday off”: Reducing Working Hours in Europe

    OpenAIRE

    Jack Rossiter; Hugh O.'Flynn; Michael Kalush; Giorgos Kallis; Nicholas Ashford

    2013-01-01

    This article explores the pros and cons for reducing working hours in Europe. To arrive to an informed judgment we review critically the theoretical and empirical literature, mostly from economics, concerning the relation between working hours on the one hand, and productivity, employment, quality of life, and the environment, on the other. We adopt a binary economics distinction between capital and labor productiveness, and are concerned with how working hours may be reduced without harming ...

  3. Increased instruction hours and the widening gap in student performance

    OpenAIRE

    Huebener, Mathias; Kuger, Susanne; Marcus, Jan

    2016-01-01

    Do increased instruction hours improve the performance of all students? Using PISA scores of students in ninth grade, we analyse the effect of a German education reform that increased weekly instruction hours by two hours (6.5 percent) overalmost five years. In the additional time, students are taught new learning content. On average, the reform improves student performance. However, treatment effects are small and differ across the student performance distribution. While low-performing stude...

  4. Working hours and health behaviour among nurses at public hospitals

    Directory of Open Access Journals (Sweden)

    Juliana da Costa Fernandes

    2013-09-01

    Full Text Available OBJECTIVE: to analyse the differences between genders in the description in the professional, domestic and total work hours and assess its association with health-related behaviour among nurses. METHODS: this is a transversal study carried out in 18 different public hospitals in the municipality of Rio de Janeiro. The data collection procedure was based on questionnaires. All nurses working with assistance were considered eligible (n=2,279. RESULTS: men and women showed significant differences in relation to working hours. The female group showed longer domestic and total work hours when compared to the group of men. In contrast, the number of hours spent on professional work was higher among men. For the women, both the professional hours and total work hours were often associated with excessive consumption of fried food and also coffee, lack of physical exercise and also the greater occurrence of overweight and obesity. CONCLUSION: both the professional hours and the domestic work hours need to be taken into account in studies about health, self-care and also the care provided within the context of nursing workers, particularly among women. The results add weight to the need for actions for health promotion in this occupational group and the importance of assessing the impact of long working hours on the health of workers.

  5. 地塞米松抑制试验中血、尿皮质醇对库欣综合征的诊断价值%Comparison of efficacy between the serum cortisol and 24 hour urine free cortisol in combined dexamethasone suppression test in the diagnosis of Cushing syndrome

    Institute of Scientific and Technical Information of China (English)

    卢琳; 陈佳蕙; 朱惠娟; 宋爱羚; 李明; 陈适; 潘慧; 龚凤英; 王任直

    2016-01-01

    目的 评价地塞米松抑制试验(DST)中24h尿游离皮质醇(24 h UFC)和血皮质醇对库欣综合征(CS)的诊断价值.方法 对北京协和医院2011年1月至2015年11月67例CS患者进行联合DST,比较同步血皮质醇和24 h UFC在诊断中的差别.结果 小剂量DST中血皮质醇<50 nmol/L诊断灵敏度最高,为97.01%(P<0.05);24 h UFC< 32 nmol,血皮质醇<110 nmol/L、140 nmol/L和对照值50%的诊断灵敏度分别为92.54%,86.57%,83.58%和70.15%.大剂量DST中如切点为抑制率≥50%,24 h UFC诊断库欣病的灵敏度和特异度为90.57%和96.00%,均高于血皮质醇的60.38%和91.43%(均P<0.05).受试者工作特征曲线分析结果显示,24 h UFC抑制率为60.85%时,达到灵敏度(92.6%)、特异度(85.7%)最佳界值;而血皮质醇抑制率为61.53%时也能达到最佳灵敏度(64.8%)和特异度(78.6%).结论 在小剂量DST中血皮质醇<50 nmol/L诊断灵敏度最高;而在大剂量DST中24 h UFC的诊断灵敏度和特异度高于血皮质醇.%Objective To compare the sensitivity and specificity between the 24 hour urine free cortisol (24 h UFC) and serum cortisol in dexamethasone suppression test (DST) in the diagnosis of Cushing syndrome (CS).Methods Combined low dose DST (LDDST) and high dose DST (HDDST) were carried out in 67 cases of CS with surgically confirmed cases in recent 3 years (from January 2011 to November 2015).The serum cortisol and 24 h UFC were collected simultaneously for each subject and the sensitivity and specificity of serum cortisol and 24 h UFC were compared.Results There were Cushing disease (CD) group (n =53),ectopic adrenocorticotropic hormone (ACTH) syndrome group (n =7) and ACTH-independent Cushing syndrome group (n =7) according to the etiology of hypercorticordism.There were no significant differences among 3 groups in gender and age.The sensitivity of serum cortisol of different cut off points(50,110,140 nmol/L and 50% of control) after

  6. Prevalence of gastrointestinal parasites in captive non-human primates of twenty-four zoological gardens in China.

    Science.gov (United States)

    Li, Mei; Zhao, Bo; Li, Bo; Wang, Qiang; Niu, Lili; Deng, Jiabo; Gu, Xiaobin; Peng, Xuerong; Wang, Tao; Yang, Guangyou

    2015-06-01

    Captive primates are susceptible to gastrointestinal (GIT) parasitic infections, which are often zoonotic and can contribute to morbidity and mortality. Fecal samples were examined by the means of direct smear, fecal flotation, fecal sedimentation, and fecal cultures. Of 26.51% (317/1196) of the captive primates were diagnosed gastrointestinal parasitic infections. Trichuris spp. were the most predominant in the primates, while Entamoeba spp. were the most prevalent in Old World monkeys (P primates and the safety of animal keepers and visitors.

  7. Twenty-four years after theYellowstone Fires: Are postfire lodgepole pine stands converging in structure and function?

    Science.gov (United States)

    Turner, Monica G; Whitby, Timothy G; Tinker, Daniel B; Romme, William H

    2016-05-01

    Disturbance and succession have long been of interest in ecology, but how landscape patterns of ecosystem structure and function evolve following large disturbances is poorly understood. After nearly 25 years, lodgepole pine (Pinus contorta var. latifolia) forests that regenerated after the 1988 Yellowstone Fires (Wyoming, USA) offer a prime opportunity to track the fate of disturbance-created heterogeneity in stand structure and function in a wilderness setting. In 2012, we resampled 72 permanent plots to ask (1) How have postfire stand structure and function changed between 11 and 24 yr postfire, and what variables explain these patterns and changes? (2) How has landscape-level (among-stand) variability in postfire stand structure and function changed between 11 and 24 yr postfire? We expected to see evidence of convergence beginning to emerge, but also that initial postfire stem density would still determine trajectories of biomass accumulation. After 24 yr, postfire lodgepole pine density remained very high (mean = 21,738 stems/ha, range = 0-344,067 stems/ha). Stem density increased in most plots between 11 and 24 yr postfire, but declined sharply where 11-yr-postfire stem density was > 72,000 stems/ha. Stems were small in high-density stands, but stand-level lodgepole pine leaf area, foliage biomass, and live aboveground biomass increased over time and with increasing stem density. After 24 yr, mean annual lodgepole pine aboveground net primary production (ANPP) was high (mean = 5 Mg · ha⁻¹ · yr⁻¹, range = 0-16.5 Mg · ha⁻¹ · yr⁻¹). Among stands, lodgepole pine ANPP increased with stem density, which explained 69% of the variation; another 8% of the variation was explained by environmental covariates. Early patterns of postfire lodgepole pine regeneration, which were contingent on prefire serotiny and fire severity, remained the dominant driver of stand structure and function. We observed mechanisms that would lead to convergence in stem density (structure) over time, but it was landscape variation in functional variables that declined substantially. Stand structure and function have not converged across the burned landscape, but our evidence suggests function will converge sooner than structure.

  8. Evaluation of Parents’ Knowledges and Experiences about Infant Feeding in Children between Six-Twenty Four Months

    OpenAIRE

    Zeynep Kaya; Özgül Yiğit; Meltem Erol; Özlem Bostan Gayret

    2016-01-01

    Aim: Complementary feeding is important in early childhood. Therefore, raising awareness of families about complementary feeding is of importance. In this study, we aimed to evaluate the parents’ knowledge and experience of infant feeding. Methods: This study was made in the pediatric outpatient clinic at Bağcılar Training and Research Hospital between 25.09.2012 and 25.11.2012. A questionnaire including questions regarding infant feeding was administered to 417 parents (250 mothers, 167 f...

  9. A Seroprevalence Survey of Maedi-Visna Among Twenty-Four Ovine Floks from Twelve Regions of China

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ke-shan; HE Ji-jun; LIU Yong-jie; SHANG You-jun; LIU Xiang-tao

    2013-01-01

    Maedi-visna virus (MVV) is an ovine lentivirus that is widespread in many countries worldwide. Both clinical and subclinical MVV infections cause substantial economic losses. MVV infection in live sheep is usually diagnosed serologically, with antibody-positive sheep being regarded as infected. There have been few reports of maedi-visna in China, with no detailed epidemic analysis of MVV infection in ovine herds. In order to investigate the seroprevalence and spatial distribution of maedi-visna among ovine lfocks in China, a total of 672 serum samples were collected from different ovine lfocks in 12 regions (provinces, autonomous regions or municipalities) of China in 2011, and serum antibody levels were determined using a commercial ELISA Kit. This study represents the ifrst investigation of the seroepidemiology of maedi-visna in China, indicating a circulation of MMV among sheep.

  10. Group of Twenty Four Countries and Three Tiers: An International Comparative Study on China’s Urbanization

    Institute of Scientific and Technical Information of China (English)

    Li; Hao; Li; Min

    2015-01-01

    It is of great signif icance to conduct an international comparative study on China’s and other countries’ urbanization by taking the concept of "scale" as a crucial study point. This paper puts forward that countries with an area over two million km2 or a GDP over 650 billion dollars are comparable with China. Accordingly, there are 24 such countries in the world leading the global socio-economic development. For consisting of almost all types of countries, they can be considered as basic references for international comparative studies on China’s urbanization. Based on the relationship between urbanization and economic levels, the 24 countries can be divided into three tiers. The fi rst tier countries are mainly developed countries at high urbanization and economic levels; the second tier countries are later starters yet urbanized at a rapid speed, thus have fallen into the "middle-income trap" because of an imbalanced urbanization and economic development; the third tier countries including China and India are still in the starting phase of urbanization, and the key to their future development is a steady economic growth and a balanced urbanization and economic development.

  11. 75 FR 71545 - Changes to NARA Facilities' Hours of Operation

    Science.gov (United States)

    2010-11-24

    ... Personnel Records Center archival research room is located at 9700 Page Ave., St. Louis, MO 63132-5100. The... located at 700 Pennsylvania Avenue, NW., Washington, DC 20408. Hours for the Research Center and the Central Research Room are posted at http://www.archives.gov . The exhibit areas' hours of operation are...

  12. 75 FR 54543 - Changes to NARA Facilities' Hours of Operation

    Science.gov (United States)

    2010-09-08

    ... archival research room is located at 9700 Page Ave., St. Louis, MO 63132-5100. The telephone number is 314... Building is located at 700 Pennsylvania Avenue, NW., Washington, DC 20408. Hours for the Research Center and the Central Research Room are posted at http://www.archives.gov . The exhibit areas' hours of...

  13. Contact Hours in Dutch and Vietnamese Higher Education: A Comparison

    Science.gov (United States)

    Quyen, Do Thi Ngoc

    2009-01-01

    The number of contact hours, one of the important institutional context factors, was examined and compared between Dutch and Vietnamese higher education at institute and student levels in Psychology and Business and/or Economics specializations. The quantity of contact hours per credit point given by institutions was investigated in a number of…

  14. Night Owl: Maryland's After-Hours Reference Service.

    Science.gov (United States)

    Duke, Deborah C.

    1994-01-01

    Discusses "Night Owl," a Maryland public library's after hours telephone reference service. Issues include project start-up, user profiles, types of questions, volume, after hours reference accessibility, security, costs, service limits, publicity, staffing, and employee turnover. Similar services in other states are cited. (Contains six…

  15. Human prolactin - 24-hour pattern with increased release during sleep.

    Science.gov (United States)

    Sassin, J. F.; Weitzman, E. D.; Kapen, S.; Frantz, A. G.

    1972-01-01

    Human prolactin was measured in plasma by radioimmunoassay at 20-minute intervals for a 24-hour period in each of six normal adults, whose sleep-wake cycles were monitored polygraphically. A marked diurnal variation in plasma concentrations was demonstrated, with highest values during sleep. Periods of episodic release occurred throughout the 24 hours.

  16. No Correlation Between Work-Hours and Operative Volumes

    DEFF Research Database (Denmark)

    Kjærgaard, Jane; Sillesen, Martin; Beier-Holgersen, Randi

    2016-01-01

    OBJECTIVE: Since 2003, United States residents have been limited to an 80-hour workweek. This has prompted concerns of reduced educational quality, especially inadequate operating exposure. In contrast, the Danish surgical specialty-training program mandates a cap on working hours of 37 per week....

  17. With long hours of work, might depression then lurk?

    DEFF Research Database (Denmark)

    Varma, Anshu; Marott, Jacob Louis; Stoltenberg, Christian Ditlev Gabriel;

    2012-01-01

    The aim of this study was to examine depression as a potential negative health effect of long work hours, anticipating an exposure-response relationship.......The aim of this study was to examine depression as a potential negative health effect of long work hours, anticipating an exposure-response relationship....

  18. 39 CFR 959.3 - Office, business hours.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Office, business hours. 959.3 Section 959.3 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.3 Office, business hours. The offices of the officials mentioned in these rules...

  19. 39 CFR 952.4 - Office business hours.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Office business hours. 952.4 Section 952.4 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.4 Office business hours. The offices of the officials mentioned in...

  20. 39 CFR 954.4 - Office business hours.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Office business hours. 954.4 Section 954.4 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO THE DENIAL, SUSPENSION, OR REVOCATION OF PERIODICALS MAIL PRIVILEGES § 954.4 Office business hours. The offices of...

  1. 75 FR 19555 - NARA Facility Locations and Hours

    Science.gov (United States)

    2010-04-15

    ..., and 1280 [FDMS Docket NARA-10-0002] RIN 3095-AB66 NARA Facility Locations and Hours AGENCY: National... Regional Records Service Office, and the addition of facility information for the locations of two NARA... facility added. * * * * * PART 1253--LOCATION OF RECORDS AND HOURS OF USE 0 3. The authority citation for...

  2. 12 CFR 905.3 - Location and business hours.

    Science.gov (United States)

    2010-01-01

    ... Location and business hours. (a) Location. All office units of the Finance Board are located at 1777 F... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Location and business hours. 905.3 Section 905.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOUSING FINANCE BOARD ORGANIZATION...

  3. 19 CFR 132.3 - Observation of official hours.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Observation of official hours. 132.3 Section 132.3 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY QUOTAS General Provisions § 132.3 Observation of official hours. An entry summary for consumption...

  4. 5 CFR 551.421 - Regular working hours.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Regular working hours. 551.421 Section 551.421 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Hours of Work Application of Principles in Relation to...

  5. Maximizing utilization of sport halls during peak hours

    DEFF Research Database (Denmark)

    Iversen, Evald Bundgård; Forsberg, Peter

    be increased during peak hours. DATA AND METHODOLOGYData is collected by observation of activities during two weeks on for example whether halls are used or not; the amount of playing field used; and number of participants (Iversen, 2012). Data on 1.331 activities in 36 sport halls across 4 municipalities have...... been collected. RESULTS The number of participants per activity is higher during peak hours, which is expected when demand is high. However, the usage of sport floor only differs slightly between peak and low hours. Both during peak and low hours on average 80-100 per cent of floor space is used......BACKGROUNDDuring peak hours (4.30pm-8pm) demand for timeslots in sport halls in Denmark are high and there are few timeslots available. Further, focus on how public resources are spent most efficient is increasing (Iversen, 2013). This makes it interesting to analyse how utilization could...

  6. Unsupervised/supervised learning concept for 24-hour load forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Djukanovic, M. (Electrical Engineering Inst. ' Nikola Tesla' , Belgrade (Yugoslavia)); Babic, B. (Electrical Power Industry of Serbia, Belgrade (Yugoslavia)); Sobajic, D.J.; Pao, Y.-H. (Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Electrical Engineering and Computer Science)

    1993-07-01

    An application of artificial neural networks in short-term load forecasting is described. An algorithm using an unsupervised/supervised learning concept and historical relationship between the load and temperature for a given season, day type and hour of the day to forecast hourly electric load with a lead time of 24 hours is proposed. An additional approach using functional link net, temperature variables, average load and last one-hour load of previous day is introduced and compared with the ANN model with one hidden layer load forecast. In spite of limited available weather variables (maximum, minimum and average temperature for the day) quite acceptable results have been achieved. The 24-hour-ahead forecast errors (absolute average) ranged from 2.78% for Saturdays and 3.12% for working days to 3.54% for Sundays. (Author)

  7. THE EFFECTS OF 30 HOURS SLEEP DEPRIVATION ON BASIC FOOTBALL SKILLS OF SOCCER PLAYERS

    OpenAIRE

    2012-01-01

    The aim of this study is to determine the effect of sleep deprivation on the passing and shooting skills of football players. To this end, 18 students of Sahand University, with age range 20 to 24 years performed basic soccer skills (shoot and pass) in the pre-test and post test stages. In this study to assess these skills, the test "Mor - Christian" has been used. In the first step, subjects conducted the shoot and pass test as pre-test after 8 hours sleep a night. 10 days later, to ensure t...

  8. Spatial characteristics of extreme rainfall over China with hourly through 24-hour accumulation periods based on national-level hourly rain gauge data

    Science.gov (United States)

    Zheng, Yongguang; Xue, Ming; Li, Bo; Chen, Jiong; Tao, Zuyu

    2016-11-01

    Hourly rainfall measurements of 1919 national-level meteorological stations from 1981 through 2012 are used to document, for the first time, the climatology of extreme rainfall in hourly through 24-h accumulation periods in China. Rainfall amounts for 3-, 6-, 12- and 24-h periods at each station are constructed through running accumulation from hourly rainfall data that have been screened by proper quality control procedures. For each station and for each accumulation period, the historical maximum is found, and the corresponding 50-year return values are estimated using generalized extreme value theory. Based on the percentiles of the two types of extreme rainfall values among all the stations, standard thresholds separating Grade I, Grade II and Grade III extreme rainfall are established, which roughly correspond to the 70th and 90th percentiles for each of the accumulation periods. The spatial characteristics of the two types of extreme rainfall are then examined for different accumulation periods. The spatial distributions of extreme rainfall in hourly through 6-h periods are more similar than those of 12- and 24-h periods. Grade III rainfall is mostly found over South China, the western Sichuan Basin, along the southern and eastern coastlines, and in the large river basins and plains. There are similar numbers of stations with Grade III extreme hourly rainfall north and south of 30°N, but the percentage increases to about 70% south of 30°N as the accumulation period increases to 24 hours, reflecting richer moisture and more prolonged rain events in southern China. Potential applications of the extreme rainfall climatology and classification standards are suggested at the end.

  9. Modelling hourly rates of evaporation from small lakes

    Directory of Open Access Journals (Sweden)

    R. J. Granger

    2011-01-01

    Full Text Available The paper presents the results of a field study of open water evaporation carried out on three small lakes in Western and Northern Canada. In this case small lakes are defined as those for which the temperature above the water surface is governed by the upwind land surface conditions; that is, a continuous boundary layer exists over the lake, and large-scale atmospheric effects such as entrainment do not come into play. Lake evaporation was measured directly using eddy covariance equipment; profiles of wind speed, air temperature and humidity were also obtained over the water surfaces. Observations were made as well over the upwind land surface.

    The major factors controlling open water evaporation were examined. The study showed that for time periods shorter than daily, the open water evaporation bears no relationship to the net radiation; the wind speed is the most significant factor governing the evaporation rates, followed by the land-water temperature contrast and the land-water vapour pressure contrast. The effect of the stability on the wind field was demonstrated; relationships were developed relating the land-water wind speed contrast to the land-water temperature contrast. The open water period can be separated into two distinct evaporative regimes: the warming period in the Spring, when the land is warmer than the water, the turbulent fluxes over water are suppressed; and the cooling period, when the water is warmer than the land, the turbulent fluxes over water are enhanced.

    Relationships were developed between the hourly rates of lake evaporation and the following significant variables and parameters (wind speed, land-lake temperature and humidity contrasts, and the downwind distance from shore. The result is a relatively simple versatile model for estimating the hourly lake evaporation rates. The model was tested using two independent data sets. Results show that the modelled evaporation follows the observed values

  10. Home blood sugar testing

    Science.gov (United States)

    Diabetes - home glucose testing; Diabetes - home blood sugar testing ... Usual times to test your blood sugar are before meals and at bedtime. Your provider may ask you to check your blood sugar 2 hours after a meal or ...

  11. ALP isoenzyme test

    Science.gov (United States)

    Alkaline phosphatase isoenzyme test ... anything for 10 to 12 hours before the test, unless your health care provider tells you to do so. Many medicines can interfere with blood test results. Your health care provider will tell you ...

  12. Impact of working hours on sleep and mental health.

    Science.gov (United States)

    Afonso, P; Fonseca, M; Pires, J F

    2017-07-01

    The number of hours people are required to work has a pervasive influence on both physical and mental health. Excessive working hours can also negatively affect sleep quality. The impact at work of mental health problems can have serious consequences for individuals' as well as for organizations' productivity. To evaluate differences in sleep quality and anxiety and depression symptoms between longer working hours group (LWHG) and regular working hours group (RWHG). To examine factors influencing weekly working hours, sleep quality and anxiety and depressive symptoms. Participants were divided into two groups, RWHG and LWHG, based on working hours, with a cut-off of 48 h per week. We used the Hospital Anxiety and Depression Scale (HADS) to assess anxiety and depression symptoms and the Pittsburgh Sleep Quality Index (PSQI) to measure the quality and patterns of sleep. The response rate was 23%. Among the 429 study participants, those in the LWHG group (n = 256, 53%) had significantly more depressive and anxiety symptoms and worse sleep quality than those in RWHG (n = 223, 47%). Working time was significantly positively correlated with higher corporate position and HADS scores. Moreover, HADS scores were positively correlated with PSQI scores and negatively correlated with age. This study suggests that longer working hours are associated with poorer mental health status and increasing levels of anxiety and depression symptoms. There was a positive correlation between these symptoms and sleep disturbances.

  13. Work hours, social value of leisure and globalisation

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Molana, Hassan; Montagna, Catia

    2012-01-01

    and raises the wage rate; there is a U-shaped (inverse-U-shaped) relationship between work hours (wages) and the degree of coordination; coordination is welfare improving; and, the gap between the coordinated and uncoordinated work hours (and the corresponding wage rates) is affected by the extent and nature......We examine how openness interacts with the coordination of consumption-leisure decisions in determining the equilibrium working hours and wage rate when there are leisure externalities (e.g., due to social interactions). The latter are modelled by allowing a worker’s marginal utility of leisure...

  14. Work Hours, Social Value of Leisure and Globalisation

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Nielsen, Jørgen Ulff-Møller; Montagna, Catia

    and raises the wage rate; there is a U-shaped (inverse-U-shaped) relationship between work hours (wages) and the degree of coordination; coordination is welfare improving; and, the gap between the coordinated and uncoordinated work hours (and the corresponding wage rates) is affected by the extent and nature......We examine how openness interacts with the coordination of consumption-leisure decisions in determining the equilibrium working hours and wage rate when there are leisure externalities (e.g., due to social interactions). The latter are modelled by allowing a worker's marginal utility of leisure...

  15. Work Hours, Social Value of Leisure and Globalisation

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Molana, Hassan; Montagna, Catia

    2010-01-01

    and raises the wage rate; there is a U-shaped (inverse-U-shaped) relationship between work hours (wages) and the degree of coordination; coordination is welfare improving; and, the gap between the coordinated and uncoordinated work hours (and the corresponding wage rates) is affected by the extent and nature......We examine how openness interacts with the coordination of consumption-leisure decisions in determining the equilibrium working hours and wage rate when there are leisure externalities (e.g., due to social interactions). The latter are modelled by allowing a worker's marginal utility of leisure...

  16. 29 CFR 778.324 - Effect on hourly rate employees.

    Science.gov (United States)

    2010-07-01

    ... OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Special... is accompanied by a new agreement altering the mode of compensation from an hourly rate basis to...

  17. Choice or constraint? Women's weekly working hours in comparative perspective

    NARCIS (Netherlands)

    M.A. Yerkes (Mara)

    2013-01-01

    textabstractThis article analyses the influence of individualworking preferences onwomen's labour market behaviour in the Netherlands, Germany and the United Kingdom, addressing the question: to what extent do individual preferences have a causal effect onwomen's averageweeklyworking hours? Using

  18. Balancing Authority Cooperation Concepts - Intra-Hour Scheduling

    Energy Technology Data Exchange (ETDEWEB)

    Hunsaker, Matthew; Samaan, Nader; Milligan, Michael; Guo, Tao; Liu, Guangjuan; Toolson, Jacob

    2013-03-29

    The overall objective of this study was to understand, on an Interconnection-wide basis, the effects intra-hour scheduling compared to hourly scheduling. Moreover, the study sought to understand how the benefits of intra-hour scheduling would change by altering the input assumptions in different scenarios. This report describes results of three separate scenarios with differing key assumptions and comparing the production costs between hourly scheduling and 10-minute scheduling performance. The different scenarios were chosen to provide insight into how the estimated benefits might change by altering input assumptions. Several key assumptions were different in the three scenarios, however most assumptions were similar and/or unchanged among the scenarios.

  19. Surface Airways Observations (SAO) Hourly Data 1928-1948 (CDMP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The dataset consists of hourly U.S. surface airways observations (SAO). These observations extend as far back as 1928, from the time when commercial aviation began...

  20. NOS CO-OPS Water Level Data, Verified, Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), hourly, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  1. 100 Hours of Astronomy Cornerstone Project of IYA2009

    Science.gov (United States)

    Simmons, M.

    2008-11-01

    The 100 Hours of Astronomy cornerstone project (100HA) is a round-the-clock, worldwide event with 100 continuous hours of a wide range of public outreach activities taking place from 2--5 April. A high-profile opening event will include presentation of Galileo's original telescope. Webcasts of international science center discussions and 24 hours of webcasts from professional research observatories will follow. A 24-hour global star party will occur on the last day. The Moon's phase will range from first quarter to gibbous, good phases for early evening observing, and Saturn will also be well placed for early evening observing events. Amateur astronomers will be encouraged to present educational events in schools as well as non-traditional venues. Online resources will include advertising, educational and how-to materials.

  2. U.S. Hourly Climate Normals (1981-2010)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The U.S. Hourly Climate Normals for 1981 to 2010 are 30-year averages of meteorological parameters for thousands of U.S. stations located across the 50 states, as...

  3. US EPA Region 9 1-Hour Ozone NAAQS Designations

    Data.gov (United States)

    U.S. Environmental Protection Agency — Esri polygon shapefile of 1-hour ozone designated areas in US EPA Region 9. Nonattainment areas are geographic areas which have not met National Ambient Air Quality...

  4. US EPA Region 9 24-Hour PM-25 Designated Areas

    Data.gov (United States)

    U.S. Environmental Protection Agency — Designated Areas for particulate matter less than 2.5 microns, according to the 24-Hour National Ambient Air Quality Standards (NAAQS). Nonattainment areas are...

  5. Enhanced Hourly Wind Station Data for the Contiguous United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — U.S. Enhanced Hourly Wind Station Data is digital data set DSI-6421, archived at the National Centers for Environmental Information (NCEI; formerly National Climatic...

  6. Unemployment and Hours of Work: The North Atlantic Divide Revisited

    OpenAIRE

    Christopher Pissarides

    2006-01-01

    I examine the dynamic evolutions of unemployment, hours of work and the service share since the war in the United States and Europe. The theoretical model brings together all three and emphasizes technological growth. Computations show that the very low unemployment in Europe in the 1960s was due to the high productivity growth associated with technological catch-up. Productivity also played a role in the dynamics of hours but a full explanation for the fast rise of service employment and the...

  7. Modeling the Distribution of Rainfall Intensity using Hourly Data

    OpenAIRE

    Salisu Dan'azumi; Supiah Shamsudin; Azmi Aris

    2010-01-01

    Problem statement: Design of storm water best management practices to control runoff and water pollution can be achieved if a prior knowledge of the distribution of rainfall characteristics is known. Rainfall intensity, particularly in tropical climate, plays a major role in the design of runoff conveyance and erosion control systems. This study is aimed to explore the statistical distribution of rainfall intensity for Peninsular Malaysia using hourly rainfall data. Approach: Hourly rainfall ...

  8. Hourly weather forecasts for gas turbine power generation

    OpenAIRE

    G. Giunta; R. Vernazza; Salerno, R.; Ceppi, A.; Ercolani, G.; Mancini, M

    2017-01-01

    An hourly short-term weather forecast can optimize processes in Combined Cycle Gas Turbine (CCGT) plants by helping to reduce imbalance charges on the national power grid. Consequently, a reliable meteorological prediction for a given power plant is crucial for obtaining competitive prices for the electric market, better planning and stock management, sales and supplies of energy sources. The paper discusses the short-term hourly temperature forecasts, at lead time day+1 and day+2, over a per...

  9. Verification of hourly forecasts of wind turbine power output

    Energy Technology Data Exchange (ETDEWEB)

    Wegley, H.L.

    1984-08-01

    A verification of hourly average wind speed forecasts in terms of hourly average power output of a MOD-2 was performed for four sites. Site-specific probabilistic transformation models were developed to transform the forecast and observed hourly average speeds to the percent probability of exceedance of an hourly average power output. (This transformation model also appears to have value in predicting annual energy production for use in wind energy feasibility studies.) The transformed forecasts were verified in a deterministic sense (i.e., as continuous values) and in a probabilistic sense (based upon the probability of power output falling in a specified category). Since the smoothing effects of time averaging are very pronounced, the 90% probability of exceedance was built into the transformation models. Semiobjective and objective (model output statistics) forecasts were made compared for the four sites. The verification results indicate that the correct category can be forecast an average of 75% of the time over a 24-hour period. Accuracy generally decreases with projection time out to approx. 18 hours and then may increase due to the fairly regular diurnal wind patterns that occur at many sites. The ability to forecast the correct power output category increases with increasing power output because occurrences of high hourly average power output (near rated) are relatively rare and are generally not forecast. The semiobjective forecasts proved superior to model output statistics in forecasting high values of power output and in the shorter time frames (1 to 6 hours). However, model output statistics were slightly more accurate at other power output levels and times. Noticeable differences were observed between deterministic and probabilistic (categorical) forecast verification results.

  10. Multiplicative ARMA models to generate hourly series of global irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Mora-Lopez, L. [Universidad de Malaga (Spain). Dpto. Lenguajes y C. Computacion; Sidrach-de-Cardona, M. [Universidad de Malaga (Spain). Dpto. Fisica Aplicada

    1998-11-01

    A methodology to generate hourly series of global irradiation is proposed. The only input parameter which is required is the monthly mean value of daily global irradiation, which is available for most locations. The procedure to obtain new series is based on the use of a multiplicative autoregressive moving-average statistical model for time series with regular and seasonal components. The multiplicative nature of these models enables capture of the two types of relationships observed in recorded hourly series of global irradiation: on the one hand, the relationship between the value at one hour and the value at the previous hour; and on the other hand, the relationship between the value at one hour in one day and the value at the same hour in the previous day. In this paper the main drawback which arises when using these models to generate new series is solved: namely, the need for available recorded series in order to obtain the three parameters contained in the statistical ARMA model which is proposed (autoregressive coefficient, moving-average coefficient and variance of the error term). Specifically, expressions which enable estimation of these parameters using only monthly mean values of daily global irradiation are proposed in this paper. (author)

  11. “Friday off”: Reducing Working Hours in Europe

    Directory of Open Access Journals (Sweden)

    Jack Rossiter

    2013-04-01

    Full Text Available This article explores the pros and cons for reducing working hours in Europe. To arrive to an informed judgment we review critically the theoretical and empirical literature, mostly from economics, concerning the relation between working hours on the one hand, and productivity, employment, quality of life, and the environment, on the other. We adopt a binary economics distinction between capital and labor productiveness, and are concerned with how working hours may be reduced without harming the earning capacity of workers. There are reasons to believe that reducing working hours may absorb some unemployment, especially in the short-run, even if less than what is advocated by proponents of the proposal. Further, there may well be strong benefits for the quality of peoples’ lives. Environmental benefits are likely but depend crucially on complementary policies or social conditions that will ensure that the time liberated will not be directed to resource-intensive or environmentally harmful consumption. It is questionable whether reduced working hours are sustainable in the long-term given resource limits and climate change. We conclude that while the results of reducing working hours are uncertain, this may be a risk worth taking, especially as an interim measure that may relieve unemployment while other necessary structural changes are instituted.

  12. ACGME proposes dropping the 16 hour resident shift limit

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2016-11-01

    Full Text Available No abstract available. Article truncated after 150 words. The Accreditation Council for Graduate Medical Education (ACGME is proposing that first-year residents would no longer be limited to 16-hour shifts during the 2017-2018 academic year under a controversial proposal released today (1. Instead, individual residency programs could assign first-year trainees to shifts as long as 28 hours, the current limit for all other residents. The 28-hour maximum includes 4 transitional hours that's designed in part to help residents improve continuity of care. The plan to revise training requirements does not change other rules designed to protect all residents from overwork. including the maximum80 hours per week. The ACGME capped the shifts of first-year residents at 16 hours in 2011 as a part of an ongoing effort to make trainee schedules more humane and avoid clinical errors caused by sleep deprivation. ACGME CEO Thomas Nasca, MD, told Medscape Medical News that the problem arises largely from first-year residents not being ...

  13. Analysis of 72-hour sterility of common pediatric continuous intravenous infusions.

    Science.gov (United States)

    Piro, Christina C; Davis, Jennifer; Frelix, Arlesia; Grisso, Alison G; Sinclair-Pingel, Julie; Willingham, Harold; Wright, Lorianne; Potts, Amy L

    2009-01-01

    Patient morbidity and mortality associated with contaminated and improperly prepared sterile products has captured national attention. In response, both the United States Pharmacopeia (USP) and Centers for Disease Control (CDC) have published recommendations in an effort to minimize the risk of infection. While the CDC recommends that administration sets are not changed more frequently than every 72 hours, the USP recommends a maximum beyond use date of 48 hours. Neither organization provides specific guidance on expiration dating once the intravenous drug is dispensed. Likewise, neither addresses the length of time that a bag containing medication for continuous infusion may hang once administration to the patient has begun. We evaluated the sterility of medications that are commonly administered by continuous infusion to pediatric patients. Because frequent manipulation of infusion and administration sets may predispose the patient to adverse events, we evaluated sterility for extended beyond use dating up to 72 hours. Thirty-five common intravenous (IV) continuous infusions using 94 standard concentrations and diluents were identified. IV solutions were mixed using sterile technique in the laminar flow hood in accordance with USP guidelines. Medications were excluded for short stability, short durations of use or high cost. A sample from each solution was tested for contamination or bacterial growth at 72 hours. Any visible discoloration suggesting physical instability was also evaluated. None of the syringes or chambers resulted in contamination, bacterial growth or discoloration after 72 hours. This study provides sufficient data that these compounded sterile products may be stored using a beyond use date up to 72 hours for a number of commonly used continuous IV infusions in pediatric patients. In our institution, this allows for a more convenient and consistent change of both administration sets and continuous infusions at 72 hours to potentially minimize

  14. Design and Testing of a Generalized Reduced Gradient Code for Nonlinear Programming

    Science.gov (United States)

    1976-02-01

    Penalty Methods.. 34 6.2 Solution of Himmelblau Test Problems ...... 36 K6.3 Comparison with Two Other-NLP Codes ...... 4.1 S6.4i Comparison of Linear vs...effects of m’altiprogramming. ’-g 6.2 Solution of Himmelblau Test Problems I-’ The first twenty-four problems specified in Appendix A of reference [4... Himmelblau (221 implementing an "exact" exterior penalty method, or "Method of Multipliers"--as well as by an earlier version of the code described here

  15. Efficacy of fesoterodine over 24 hours in subjects with overactive bladder.

    Science.gov (United States)

    Staskin, David; Michel, Martin C; Nitti, Victor; Morrow, Jon D; Wang, Joseph; Guan, Zhonghong

    2010-04-01

    Fesoterodine is an antimuscarinic agent indicated for the treatment of overactive bladder (OAB) symptoms. The objective of this study was to evaluate the efficacy of fesoterodine versus placebo over selected intervals during a 24-hour period in subjects with OAB. In a post hoc analysis, data were analyzed from two randomized, double-blind, placebo-controlled 12-week phase III trials in which subjects with a history of OAB symptoms for >or=6 months were treated with morning doses of fesoterodine 4 mg, fesoterodine 8 mg, or placebo. These trials are registered at ClinicalTrials.gov (NCT00220363 and NCT00138723). Changes were evaluated in number of micturitions, urgency episodes, urgency urinary incontinence (UUI) episodes, and mean voided volume (MVV) divided into three 8-hour intervals: 08:00-15:59 (daytime), 16:00-23:59 (evening), and 00:00-07:59 (nighttime). Comparisons with placebo were made using analysis of covariance (for least squares mean changes) and Wilcoxon rank sum test (for median percent changes); differences were considered significant at p fesoterodine 4 mg and fesoterodine 8 mg compared with placebo during each 8-hour time interval (all p fesoterodine doses compared with placebo during all time intervals (all p Fesoterodine 4 mg and 8 mg given once daily demonstrated efficacy over placebo for OAB symptoms during all three 8-hour intervals of a 24-hour period, thus providing clinical support for once-daily dosing. Limitations include that this was a post hoc analysis.

  16. Fuzzy peak hour for urban road traffic network

    Science.gov (United States)

    Tian, Zhao; Jia, Li-Min; Dong, Hong-Hui; Zhang, Zun-Dong; Ye, Yang-Dong

    2015-06-01

    Traffic congestion is now nearly ubiquitous in many urban areas and frequently occurs during rush hour periods. Rush hour avoidance is an effective way to ease traffic congestion. It is significant to calculate the rush hour for alleviating traffic congestion. This paper provides a method to calculate the fuzzy peak hour of the urban traffic network considering the flow, speed and occupancy. The process of calculation is based on betweenness centrality of network theory, optimal separation method, time period weighting, probability-possibility transformations and trapezoidal approximations of fuzzy numbers. The fuzzy peak hour of the urban road traffic network (URTN) is a trapezoidal fuzzy number [m1, m2, m3, m4]. It helps us (i) to confirm a more detailed traffic condition at each moment, (ii) to distinguish the five traffic states of the traffic network in one day, (iii) to analyze the characteristic of appearance and disappearance processes of the each traffic state and (iv) to find out the time pattern of residents travel in one city.

  17. Registration error study of digital watt-hour meters under distorted conditions

    Science.gov (United States)

    Reta-Hernandez, Manuel

    The increasing application of non-linear loads based on the use of converters, uninterruptible power supplies, and other solid-state switching devices has increased the harmonic content in voltage and current at metering points. One of many problems caused by the voltage and current distortion is the effect on the watt-hour meter performance. The digital watt-hour meter is replacing the old induction meter for measuring electric energy, obtaining additional flexibility and functionality. However, the digital meter performance can be deeply affected when a dc current component is added to the distorted conditions. This dissertation presents a study of the digital watt-hour meter's performance under different nonsinusoidal conditions, including a dc current component. The work is divided into two sections: experimental and analytical. The experimental section consists of accuracy testing on several models of digital meters, both single-phase and three-phase units, subjected to computer-controlled distortion. The system setup used for the measurements was designed by using 12-bits data acquisition hardware (DAQ) and virtual-instrument software (VI) installed in a personal computer. Additional testing on electromechanical watt-hour meters is included for comparison purposes.

  18. Maximizing utilization of sport halls during peak hours

    DEFF Research Database (Denmark)

    Iversen, Evald Bundgård; Forsberg, Peter

    the number of participants 7.5 persons higher pr. activity compared to club activities. This implies that clubs during peak hours could include more participants. Another possibility to increase utilization is if the management of sport facilities forced sport clubs and other organisers to adapt......BACKGROUNDDuring peak hours (4.30pm-8pm) demand for timeslots in sport halls in Denmark are high and there are few timeslots available. Further, focus on how public resources are spent most efficient is increasing (Iversen, 2013). This makes it interesting to analyse how utilization could...... be increased during peak hours. DATA AND METHODOLOGYData is collected by observation of activities during two weeks on for example whether halls are used or not; the amount of playing field used; and number of participants (Iversen, 2012). Data on 1.331 activities in 36 sport halls across 4 municipalities have...

  19. Administrative Circular No. 23 (Rev. 4) - Special working hours

    CERN Multimedia

    Department Head Office - HR Department

    2016-01-01

    Administrative Circular No. 23 (Rev. 4) entitled "Special working hours", approved by the Director-General following discussion in the Standing Concertation Committee meeting on 22 March 2016, will be available on 1st September 2016 via the following link: https://cds.cern.ch/record/2208539.   This revised circular cancels and replaces Administrative Circular No. 23 (Rev. 3) also entitled "Special working hours" of January 2013. This document contains modifications to reflect the new career structure and ensuring the provision consistent with practice that compensation or remuneration of special working hours performed remotely is possible only in case of emergency.   This circular will enter into force on 1st September 2016.

  20. Averaging and sampling for magnetic-observatory hourly data

    Directory of Open Access Journals (Sweden)

    J. J. Love

    2010-11-01

    Full Text Available A time and frequency-domain analysis is made of the effects of averaging and sampling methods used for constructing magnetic-observatory hourly data values. Using 1-min data as a proxy for continuous, geomagnetic variation, we construct synthetic hourly values of two standard types: instantaneous "spot" measurements and simple 1-h "boxcar" averages. We compare these average-sample types with others: 2-h average, Gaussian, and "brick-wall" low-frequency-pass. Hourly spot measurements provide a statistically unbiased representation of the amplitude range of geomagnetic-field variation, but as a representation of continuous field variation over time, they are significantly affected by aliasing, especially at high latitudes. The 1-h, 2-h, and Gaussian average-samples are affected by a combination of amplitude distortion and aliasing. Brick-wall values are not affected by either amplitude distortion or aliasing, but constructing them is, in an operational setting, relatively more difficult than it is for other average-sample types. It is noteworthy that 1-h average-samples, the present standard for observatory hourly data, have properties similar to Gaussian average-samples that have been optimized for a minimum residual sum of amplitude distortion and aliasing. For 1-h average-samples from medium and low-latitude observatories, the average of the combination of amplitude distortion and aliasing is less than the 5.0 nT accuracy standard established by Intermagnet for modern 1-min data. For medium and low-latitude observatories, average differences between monthly means constructed from 1-min data and monthly means constructed from any of the hourly average-sample types considered here are less than the 1.0 nT resolution of standard databases. We recommend that observatories and World Data Centers continue the standard practice of reporting simple 1-h-average hourly values.

  1. Relationship between silent atrial fibrillation and the maximum heart rate in the 24-hour Holter: cross-sectional study.

    Science.gov (United States)

    Kruse, Marcelo Lapa; Kruse, José Cláudio Lupi; Leiria, Tiago Luiz Luz; Pires, Leonardo Martins; Gensas, Caroline Saltz; Gomes, Daniel Garcia; Boris, Douglas; Mantovani, Augusto; Lima, Gustavo Glotz de

    2014-12-01

    Occurrences of asymptomatic atrial fibrillation (AF) are common. It is important to identify AF because it increases morbidity and mortality. 24-hour Holter has been used to detect paroxysmal AF (PAF). The objective of this study was to investigate the relationship between occurrence of PAF in 24-hour Holter and the symptoms of the population studied. Cross-sectional study conducted at a cardiology hospital. 11,321 consecutive 24-hour Holter tests performed at a referral service were analyzed. Patients with pacemakers or with AF throughout the recording were excluded. There were 75 tests (0.67%) with PAF. The mean age was 67 ± 13 years and 45% were female. The heart rate (HR) over the 24 hours was a minimum of 45 ± 8 bpm, mean of 74 ± 17 bpm and maximum of 151 ± 32 bpm. Among the tests showing PAF, only 26% had symptoms. The only factor tested that showed a correlation with symptomatic AF was maximum HR (165 ± 34 versus 147 ± 30 bpm) (P = 0.03). Use of beta blockers had a protective effect against occurrence of PAF symptoms (odds ratio: 0.24, P = 0.031). PAF is a rare event in 24-hour Holter. The maximum HR during the 24 hours was the only factor correlated with symptomatic AF, and use of beta blockers had a protective effect against AF symptom occurrence.

  2. EISCAT Space Debris during the IPY- A 5000-Hour Campaign

    Science.gov (United States)

    Markkanen, J.; Jehn, R.; Krag, H.

    2009-03-01

    During the International Polar Year (IPY) in 2007-2009, EISCAT measured space debris at its Svalbard radar (ESR, latitude 78.2°N), simultaneously with the standard ionospheric measurement. From the 239 000 events which were recorded in 5060 hours only a "Quality Set" (QS) was extracted for further analysis. The QS essentially consists of 101 complete 24-hour beam park debris measurements, between 13 Mar 2007 and 10 Feb 2008, and contains about 95 000 events. The data provide a relatively dense sampling of the debris environment above ESR in the first year following the Chinese ASAT event, in January 2007. The QS is freely available in the web.

  3. Work Hours, Social Value of Leisure and Globalisation

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Molana, Hassan; Montagna, Catia

    2010-01-01

    We examine how openness interacts with the coordination of consumption-leisure decisions in determining the equilibrium working hours and wage rate when there are leisure externalities (e.g., due to social interactions). The latter are modelled by allowing a worker's marginal utility of leisure...... to be increasing in the leisure time taken by other workers. Coordination takes the form of internalising the leisure externality and other relevant constraints (e.g., labour demand). The extent of openness is measured by the degree of capital mobility. We find that: coordination lowers equilibrium work hours...

  4. Resident Work Hour Restrictions and Change Management: A Cautionary Tale.

    Science.gov (United States)

    Fang, Z Amy; Hudson, Darren

    2015-01-01

    Residents are a significant part of coverage in many hospitals. Resident associations are negotiating work hour limits to prevent fatigue-induced medical errors. Our intensive care unit experienced an unexpected resident shortage and used the opportunity to trial a shift schedule for one month. Post-surveys were sent to nurses, attending physicians and residents to evaluate the effects on staff interactions, patient safety and education quality. The trial was clearly a failure on all fronts. Work hour restrictions are a reality in medical education, and administrators need to start considering alternative staffing models and discussing alternative schedules with their medicine faculty.

  5. Are hourly precipitation extremes increasing faster than daily precipitation extremes?

    Science.gov (United States)

    Barbero, Renaud; Fowler, Hayley; Blenkinsop, Stephen; Lenderink, Geert

    2016-04-01

    Extreme precipitation events appear to be increasing with climate change in many regions of the world, including the United States. These extreme events have large societal impacts, as seen during the recent Texas-Oklahoma flooding in May 2015 which caused several billion in damages and left 47 deaths in its path. Better understanding of past changes in the characteristics of extreme rainfall events is thus critical for reliable projections of future changes. Although it has been documented in several studies that daily precipitation extremes are increasing across parts of the contiguous United States, very few studies have looked at hourly extremes. However, this is of primary importance as recent studies on the temperature scaling of extreme precipitation have shown that increases above the Clausius-Clapeyron (~ 7% °C-1) are possible for hourly precipitation. In this study, we used hourly precipitation data (HPD) from the National Climatic Data Center and extracted more than 1,000 stations across the US with more than 40 years of data spanning the period 1950-2010. As hourly measurements are often associated with a range of issues, the data underwent multiple quality control processes to exclude erroneous data. While no significant changes were found in annual maximum precipitation using both hourly and daily resolution datasets, significant increasing trends in terms of frequency of episodes exceeding present-day 95th percentiles of wet hourly/daily precipitation were observed across a significant portion of the US. The fraction of stations with significant increasing trends falls outside the confidence interval range during all seasons but the summer. While less than 12% of stations exhibit significant trends at the daily scale in the wintertime, more than 45% of stations, mostly clustered in central and Northern United States, show significant increasing trends at the hourly scale. This suggests that short-duration storms have increased faster than daily

  6. General Aviation: Hours Flown and Avionics Purchase Decisions.

    Science.gov (United States)

    1978-05-01

    cost and income on hours flown for the various hours flown categories will be considered in Section 2-4 of this chapter. 19 For the benefit of the...omitted because of irrelevance. 59 - 7it Results for the age related factors are as expected-- cider aircraft fly fewer and more recent vintage aircraft...based on the incremental benefits acquired by the "add-one," or simply a function of a larger number of owners having only one or the other type of

  7. Information meeting on the new provisions for working hours

    CERN Multimedia

    HR Department

    2008-01-01

    Monday 23 June 2008 at 14:00, Council Chamber (503/1-001) At the June 2008 Finance Committee and Council meetings, the Management will submit proposals to modify Chapter III, Section 1 of the Staff Rules and Regulations on Working Hours. These provisions will touch upon areas including compensation during the annual closure, periods of stand-by duty, plus compensation and eligibility for special working hours. A general information meeting, at which E. Chiaveri, Head of HR Department, will present the new policy, will be held on Monday 23 June at 14:00 in the Council Chamber. HR Department

  8. Comparison of Oral Intake Profiles at 2 and 8 Hours following Cesarean Section under Spinal Anesthesia

    Directory of Open Access Journals (Sweden)

    Arbabi Kalati Farshid

    2010-03-01

    Full Text Available Background: After cesarean section, practices vary considerably between institutions and individual practitioners, ranging from early oral fluids or food to delayed introduction of oral fluids and food which may be after 24 hours or more. This study was carried out to assess and compare the outcome, length of hospital stay and maternal satisfaction of early (2 hours and late (8 hours postoperative feeding after uncomplicated cesarean section done under spinal anesthesia. Materials and Methods: In this randomized clinical trial, 112 women undertaking uncomplicated cesarean section under regional anesthesia from August 2008 to August 2009 were randomly assigned to early feeding ( 2 hours after operation and late feeding (conventional 8 hours after operation groups. Two groups were compared for the occurrence of postoperative outcome, possible complications, length of hospital stay and patient´s satisfaction. Chi Squared and t-tests were used to analyze the data. Statistical significance was set at P< 0.05.Results: There were no significant differences in the demographic data and operation variables between the two groups. No significant differences were noted between the groups regarding post feeding nausea and vomiting, post operative ileus and other complications and duration of hospitalization. Compared with the late postoperative feeding, the early feeding group had a shorter mean time to first flatus (P=0.03 and higher satisfaction rate (P<0.0001. Conclusion: Early feeding (2 hours after uncomplicated cesarean in low-risk woman is associated with higher maternal satisfaction without higher rates of gastrointestinal and non gastrointestinal complications

  9. Correlations for the estimation of monthly mean hourly diffuse solar radiation: a time dependent approach

    Directory of Open Access Journals (Sweden)

    A. K. Katiyar, Akhilesh Kumar, C. K. Pandey, V. K. Katiyar, S. H. Abdi

    2010-09-01

    Full Text Available The time dependent monthly mean hourly diffuse solar radiation on a horizontal surface has been estimated for Lucknow (latitude26.75 degree, longitude 80.50 degree using least squares regression analysis. The monthly and annually regression constants are obtained. The present results are compared with the estimation of Orgill-Holands (Sol. Energy, 19 (4, 357 (1977, Erbs et. al (Sol. Energy 28 (4, 293-304(1982 and Spencer (Sol. Energy 29 (1, 19-32(1982 as well as with experimental value. The proposed constant provides better estimation for the entire year over others. Spencer, who correlate hourly diffuse fraction with clearness index, estimates lowest value except in summers when insolation in this region is very high. The accuracy of the regression constants are also checked with statistical tests of root mean square error (RMSE, mean bias error (MBE and t –statistic tests.

  10. Estimating 24-hour urinary sodium excretion from casual urinary sodium concentrations in Western populations

    DEFF Research Database (Denmark)

    Brown, Ian J; Dyer, Alan R; Chan, Queenie

    2013-01-01

    High intakes of dietary sodium are associated with elevated blood pressure levels and an increased risk of cardiovascular disease. National and international guidelines recommend reduced sodium intake in the general population, which necessitates population-wide surveillance. We assessed...... the utility of casual (spot) urine specimens in estimating 24-hour urinary sodium excretion as a marker of sodium intake in the International Cooperative Study on Salt, Other Factors, and Blood Pressure. There were 5,693 participants recruited in 1984-1987 at the ages of 20-59 years from 29 North American...... and European samples. Participants were randomly assigned to test or validation data sets. Equations derived from casual urinary sodium concentration and other variables in the test data were applied to the validation data set. Correlations between observed and estimated 24-hour sodium excretion were 0...

  11. Work Hours and Well Being: An Investigation of Moderator Effects

    Science.gov (United States)

    Pereira, Maria C.; Coelho, Filipe

    2013-01-01

    The relationship between work hours and subjective well being is marked by contradictory findings, thereby implying that it is far from being completely understood. A study of moderator effects can help explain variations in results across studies and, thus, overcome inconsistencies in past research. Accordingly, the current study aims to…

  12. 29 CFR 778.100 - The maximum-hours provisions.

    Science.gov (United States)

    2010-07-01

    ... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION The Overtime Pay... hours and overtime compensation for employees who are within the general coverage of the Act and are not... permitted for the employment of such employees in any workweek without extra compensation for overtime,...

  13. The star-bright hour : [luuletused] / Betti Alver

    Index Scriptorium Estoniae

    Alver, Betti, 1906-1989

    2006-01-01

    Sisu: The star-bright hour ; Not a dream ; The Piper ; Corals in an ancent river. Luuletused pärinevad kogumikust "Tuulelaeval valgusest on aerud = Windship with Oars of Light. (Tallinn : Huma, 2001). Orig.: Tähetund ; Mitte viirastus, meelepett ; Vilepuhuja ; Korallid Emajões

  14. Telework: Timesaving or Timeconsuming? An Investigation into Actual Working Hours

    NARCIS (Netherlands)

    Peters, P.; Wetzels, C.; Tijdens, K.

    2008-01-01

    This paper aims to clarify the relationship between telework and the actual time employees put into their jobs. One of the reported threats to teleworkers' personal lives is that in order to finish their work, they not only use up saved commuting time, but also part of their non-working hours, even

  15. Office Hours--None: An E-Mail Experiment.

    Science.gov (United States)

    Atamian, Rubik; DeMoville, Wig

    1998-01-01

    In a college accounting course, two faculty members experimented with a new approach to office hours, with all communication between students and teachers other than classroom dialog. Through electronic mail and other methods of data transmission. This included distribution of course syllabus, reading lists, study materials, and exams, and…

  16. Ocular torsion before and after 1 hour centrifugation

    NARCIS (Netherlands)

    Groen, E.; Graaf, B. de; Bles, W.; Bos, J.E.

    1996-01-01

    To assess a possible otolith contribution to effects observed following prolonged expo-sure to hyper gravity, we used video-oculography to measure ocular torsion during static and dynamic conditions of lateral body tilt (roll) before and after one hour of centrifugation with a Gx-load of 3G. Static

  17. The star-bright hour : [poems] / Betti Alver

    Index Scriptorium Estoniae

    Alver, Betti, 1906-1989

    2003-01-01

    Autori lühitutvustus lk. 231. Sisu: The star-bright hour ; The debt ; Not a dream ; Fog-bound ; Corals in an Ancient river ; Frou-frou 1-3. Orig.: Tähetund ; Vilepuhuja ; Võlg ; "Mitte viirastus, meelepett..." ; Udus ; Korallid Emajões ; Froufrou 1-3

  18. The star-bright hour : [poems] / Betti Alver

    Index Scriptorium Estoniae

    Alver, Betti, 1906-1989

    2003-01-01

    Autori lühitutvustus lk. 231. Sisu: The star-bright hour ; The debt ; Not a dream ; Fog-bound ; Corals in an Ancient river ; Frou-frou 1-3. Orig.: Tähetund ; Vilepuhuja ; Võlg ; "Mitte viirastus, meelepett..." ; Udus ; Korallid Emajões ; Froufrou 1-3

  19. 8 Hour Ozone Design Value for 1998-2000

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Ozone design value is based on the average of the annual 4th highest daily 8-hour maximum over a 3-year period (1998-2000) in this case. This is a human health...

  20. Allergic colitis presenting within the first hours of premature life.

    NARCIS (Netherlands)

    Faber, M.R.; Rieu, P.N.M.A.; Semmekrot, B.A.; Krieken, J.H.J.M. van; Tolboom, J.J.M.; Draaisma, J.M.T.

    2005-01-01

    A prematurely born infant developed rectal blood loss several hours after birth, after his first formula feeding. Discontinuing the feeding resolved symptoms, but after resuming feeding rectal blood loss reappeared. There were no signs of necrotizing enterocolitis. Suspecting cow's milk allergy, the

  1. Work Hours and Well Being: An Investigation of Moderator Effects

    Science.gov (United States)

    Pereira, Maria C.; Coelho, Filipe

    2013-01-01

    The relationship between work hours and subjective well being is marked by contradictory findings, thereby implying that it is far from being completely understood. A study of moderator effects can help explain variations in results across studies and, thus, overcome inconsistencies in past research. Accordingly, the current study aims to…

  2. "Rosetta" Mission's "7 Hours of Terror" and "Philae's" Descent

    Science.gov (United States)

    Blanco, Philip

    2015-01-01

    In November 2014 the "Rosetta" mission to Comet 67P/Churyumov-Gerasimenko made the headlines when its "Philae" lander completed a successful unpowered descent onto the surface of the comet nucleus after "7 hours of terror" for the mission scientists. 67P's irregular shape and rotation made this task even more…

  3. The star-bright hour : [luuletused] / Betti Alver

    Index Scriptorium Estoniae

    Alver, Betti, 1906-1989

    2006-01-01

    Sisu: The star-bright hour ; Not a dream ; The Piper ; Corals in an ancent river. Luuletused pärinevad kogumikust "Tuulelaeval valgusest on aerud = Windship with Oars of Light. (Tallinn : Huma, 2001). Orig.: Tähetund ; Mitte viirastus, meelepett ; Vilepuhuja ; Korallid Emajões

  4. Globalization and working time: working hours and flexibility in Germany

    NARCIS (Netherlands)

    Burgoon, B.; Raess, D.

    2009-01-01

    This article challenges popular wisdom that economic globalization uniformly increases working time in industrialized countries. International investment and trade, they argue, have uneven effects for workplace bargaining over standard hours and over work-time flexibility, such as use of temporary

  5. [A 24-hour solid state Holter recording and analyzing system].

    Science.gov (United States)

    Jia, C; Duan, H; Yan, X; Lu, W

    1998-01-01

    The design and functions of a new type of multi-channel solid-state Holter system were introduced in this paper. The flash memory card based recorder can record 24 hours or more of data from up to all 12 leads. The full function scanner software can analysis automatically and archive with complete editing capabilities.

  6. The "Death" Theme in The Story of an Hour

    Institute of Scientific and Technical Information of China (English)

    杨双菊

    2010-01-01

    The Story of an Hour,written by Kate Chopin,a famous feminist woman writer,revolves around the death and revival of Mr.Mallard and the subsequent death of Mrs.Mallard.This paper intends to interpret the psychological movement of the people about their respective death from the perspective of convention and feminist.

  7. 77 FR 7544 - Hours of Service of Drivers: Correction

    Science.gov (United States)

    2012-02-13

    .... 2011-32696, appearing on page 81134 in the Federal Register of Tuesday, December 27, 2011, the following correction is made. Sec. 395.1 On page 81186, in the third column, in Part 395--Hours of Service..., 2012. Larry W. Minor, Associate Administrator for Policy. BILLING CODE 4910-EX-P...

  8. Transferring PSM craft skills in a 2 hour session

    NARCIS (Netherlands)

    Zijderveld, E.J.A. van; Morill, N.; Shaw, D.; Belton, V.; Harvey, P.; Rouwette, E.

    2007-01-01

    Many of those involved in the Problem Structuring Methods (PSM) community have commented on the struggle that novices face in building the craft skills associated with conducting a PSM intervention. As part of this year's Operational Research Society Conference, we have three 2-hour practical

  9. Achieving the Best: Gender and the Literacy Hour.

    Science.gov (United States)

    Fisher, Helen

    2001-01-01

    A study involving 30 British elementary children investigated the relationship between reading and gender and attitudes towards the literacy hour. Findings indicate boys wanted shorter time spans of learning activities, preferred independent work, and liked computer work. Both sexes liked working in small groups and disliked sharing their work…

  10. Working Hours Flexibility and Older Workers' Labor Supply

    NARCIS (Netherlands)

    Gielen, A. C.

    2007-01-01

    This paper studies the presence of hours constraints on the UK labor market and its effect on older workers labor supply, both at the extensive and the intensive margin. Using panel data for the period 1991-2004, the results from a competing risks model show that over-employed male workers can freel

  11. "Rosetta" Mission's "7 Hours of Terror" and "Philae's" Descent

    Science.gov (United States)

    Blanco, Philip

    2015-01-01

    In November 2014 the "Rosetta" mission to Comet 67P/Churyumov-Gerasimenko made the headlines when its "Philae" lander completed a successful unpowered descent onto the surface of the comet nucleus after "7 hours of terror" for the mission scientists. 67P's irregular shape and rotation made this task even more…

  12. Globalization and working time: working hours and flexibility in Germany

    NARCIS (Netherlands)

    B. Burgoon; D. Raess

    2009-01-01

    This article challenges popular wisdom that economic globalization uniformly increases working time in industrialized countries. International investment and trade, they argue, have uneven effects for workplace bargaining over standard hours and over work-time flexibility, such as use of temporary o

  13. Precipitation Intensity Trend Detection using Hourly and Daily Observations in Portland, Oregon

    Directory of Open Access Journals (Sweden)

    Alexis Cooley

    2017-02-01

    Full Text Available The intensity of precipitation is expected to increase in response to climate change, but the regions where this may occur are unclear. The lack of certainty from climate models warrants an examination of trends in observational records. However, the temporal resolution of records may affect the success of trend detection. Daily observations are often used, but may be too coarse to detect changes. Sub-daily records may improve detection, but their value is not yet quantified. Using daily and hourly records from 24 rain gages in Portland, Oregon (OR, trends in precipitation intensity and volume are examined for the period of 1999–2015. Daily intensity is measured using the Simple Daily Intensity Index, and this method is adapted to measure hourly scale intensity. Kendall’s tau, a non-parametric correlation coefficient, is used for monotonic trend detection. Field significance and tests for spatial autocorrelation using Moran’s Index are used to determine the significance of group hypothesis tests. Results indicate that the hourly data is superior in trend detection when compared with daily data; more trends are detected with hourly scale data at both the 5% and 10% significance levels. Hourly records showed a significant increase in 6 of 12 months, while daily records showed a significant increase in 4 of 12 months at the 10% significance level. At both scales increasing trends were concentrated in spring and summer months, while no winter trends were detected. Volume was shown to be increasing in most months experiencing increased intensity, and is a probable driver of the intensity trends observed.

  14. A step towards using urinary nitrogen as a tool for validating 24-hour dietary recall interviews.

    Science.gov (United States)

    Kahn, H A

    1987-09-01

    In an active population, can urinary nitrogen output provide a satisfactory basis for estimating protein intake without preliminary screening to rule out metabolic disease? A successful demonstration would justify comparing average protein intake for active groups derived from 24-hour recall interviews with that obtained from 24-hour urine specimens. This could then be a practical test of the hypothesis that 24-hour recall data provide valid estimates for groups. Volunteers (45) from a university population limited their diet for four days to a commercially prepared liquid diet and provided a 24-hour urine specimen beginning on the morning of the fourth day. For men, average daily intake of protein was 112.8 grams and the estimated intake based on urinary nitrogen was 114.5. Corresponding data for women were 84.6 and 83.9. Screening for metabolic disease seems unnecessary but persons restricting their intake to less than their caloric needs will have their protein intake overestimated on the basis of urinary nitrogen measurement.

  15. Oropharyngeal 24-Hour pH Monitoring in Children With Airway-Related Problems

    Science.gov (United States)

    Mesallam, Tamer A.

    2016-01-01

    Objectives Diagnosis and clinical presentation of pediatric laryngopharyngeal reflux (LPR) is still controversial. The aims of this work were to study the possibility of performing 24-hour oropharyngeal pH monitoring for children in the outpatient clinic setup and to explore the results of this test in correlation to airway-related problems. Methods In this descriptive qualitative study, 26 children suffering from airway-related problems were included. Oropharyngeal 24-hour pH monitoring was performed for all subjects in the outpatient clinic setting. The distribution of airway diagnoses among the study group was studied versus the results of the pH monitoring. Results There were 16 males and 10 females participated in the study with a mean age of 6.88 (SD, ±5.77) years. Thirty-five percent of the patients were under the age of 3 years (range, 11 months to 3 years). Eight-five percent of the patients tolerated the pH probe insertion and completed 24-hour of pH recording. Laryngomalacia and subglottic stenosis (SGS) were more frequently reported in the positive LPR patients (77%). Conclusion Oropharyngeal 24-hour pH monitoring can be conducted for children in the outpatient setup even in young age children below 3 years old. Among the positive LPR group, SGS and laryngomalacia were the most commonly reported airway findings. PMID:27090271

  16. Characterization and simulation of hourly exposure series of global radiation

    Energy Technology Data Exchange (ETDEWEB)

    Mora-Lopez, L. [Universidad de Malaga (Spain). Dpto. Lenguajes y C. Computacion; Sidrach-de-Cardona, M. [Universidad de Malaga (Spain). Dpto. Fisica Aplicada

    1997-06-01

    A statistical model which captures the main features of hourly exposure series of global radiation is proposed. This model is used to obtain a procedure to generate radiation series without imposing, a priori, any restriction on the form of the probability distribution function of the series. The statistical model was taken from the stationary stochastic processes theory. Data were obtained from ten different Spanish locations. As monthly hourly exposure series of global radiation are not stationary, they are modified in order to remove the observed trends. A multiplicative autoregressive moving average model with regular and seasonal components was used. It is statistically accepted that this is the true model which generates most of the analyzed sequences. However, the underlying parameters of the model vary from one location to another and from one month to another. Therefore, it is necessary to examine further the relationship between the parameters of the model and the available data from most locations. (author)

  17. Hour-Scale Multiwavelength Variability in Markarian 421

    CERN Document Server

    Catanese, M; Bradbury, S M; Breslin, A C; Buckley, J H; Burdett, A M; Carter-Lewis, D A; Cawley, M F; Dunlea, S; D'Vali, M; Fegan, D J; Fegan, S J; Finley, J P; Gaidos, J A; Hall, T A; Hillas, A M; Horan, D; Knapp, J; Krennrich, F; Le Bohec, S; Lessard, R W; Masterson, C; Moriarty, P; Quinn, J; Rose, H J; Samuelson, F W; Sembroski, G H; Vasilev, V; Weekes, T C; Maraschi, L; Fossati, G; Tavecchio, F; Chiappetti, L; Celotti, A; Ghisellini, G; Grandi, P; Pian, E; Tagliaferri, G; Treves, A

    1999-01-01

    Markarian 421 was observed for about four days with BeppoSAX and the Whipple Observatory gamma-ray telescope in April 1998. A pronounced, well-defined, flare with hour-scale variability was observed simultaneously in X-rays and very high energy gamma-rays. These data provide the first evidence that the X-ray and TeV intensities are well correlated on time-scales of hours. While the rise of the flare occurred on a similar time-scale in the two wavebands, the decay of the flare was much more rapid in gamma rays, providing the first clear indication that the X-ray and gamma-ray emission may not be completely correlated in Markarian 421.

  18. Households’ hourly electricity consumption and peak demand in Denmark

    DEFF Research Database (Denmark)

    Møller Andersen, Frits; Baldini, Mattia; Hansen, Lars Gårn

    2017-01-01

    to a considerable introduction of electric vehicles and individual heat pumps, household consumption is expected to increase considerably, especially peak hour consumption is expected to increase. Next the paper presents results from a new experiment where household customers are given economic and/or environmental......The electrification of residential energy demand for heating and transportation is expected to increase peak load and require additional generation and transmission capacities. Electrification also provides an opportunity to increase demand response. With a focus on household electricity...... incentives to shift consumption to or away from specified hours. The experiment focuses on the present classic consumption and shows that household customers do react to incentives, but today the flexibility of the classic consumption is limited. Considering electric vehicles and individual heat pumps...

  19. A Study of Postmodern Narrative in Michael Cunningham's The Hours

    Directory of Open Access Journals (Sweden)

    Hajar Abbasi Narinabad

    2012-09-01

    Full Text Available This project aims at providing a detailed analysis of the major features of the theory of postmodern narrative and at going through the novel The Hours by the American writer Michael Cunningham concentrating on some postmodern narrative techniques. To do so, the researcher goes through the theories set forth by some postmodern theoreticians like Roland Barthes, Jacque Derrida, Jean-François Lyotard and Julia Kristeva to investigate the postmodern narrative techniques and elements used in the novel. The researcher first examines the theories and then critically applies them on the novel. The article goes through the most eminent elements of postmodern narrative including intertextuality, stream of consciousness style, fragmentation and representation respectively which are delicately utilized in The Hours. The article concludes by recommending a few directions for the further research.

  20. Effect of intraoperatory peritoneal bupivacaine irrigation on inmediate, 24 hour

    OpenAIRE

    2004-01-01

    Objective: To compare the response on inmediate, 24 hour abdominal pain and referred shoulder pain (omalgia), when an intraperitoneal irrigation of bupivacaine was used as opposed to saline irrigation, in a group of patients who has laparoscopy done in a medical center in Cali, between April and June of 2000. Material and methods: After previous authorization and consentment by all 100 patients, a placebo was applied to 50 patients and bupivacaine to the other 50 patients, without randomizat...

  1. RBC Models and the Hours-Wages Puzzle: Puzzle Solved!

    OpenAIRE

    Vasilev, Aleksandar

    2015-01-01

    This paper shows that a modified real business cycle (RBC) model, one that includes home production and fiscal spending shocks, can solve one of the RBC puzzles and generates zero correlation between wages and hours. In addition, the micro-founded model presented here provides a sound theoretical model to analyze fiscal policy in a neoclassical framework and is able to capture many aspects of the data that the benchmark RBC model was missing.

  2. The Efficacy of Amphetamines for 64 Hours of Sustained Operations

    Science.gov (United States)

    2000-03-01

    effects attributable to Dexedrine; functions of polyphasic and ultrashort sleep , however, one subject evidenced increased diastolic 217-244. Boston...the Adaptability to Irregular Rest-Work Rhythms/Status of the Use of Drugs in Sleep -Wakefulness Management [les Differences entre individus concernant...system (CNS) stimulant that improves of the usefulness of dextroamphetamine beyond 40- alertness and postpones the need for sleep . In aviation, hour

  3. Analysis of the Story of an Hour from Feminist Approaches

    Institute of Scientific and Technical Information of China (English)

    任立立

    2014-01-01

    The Story of an Hour is a short story written by Kate Chopin in 1894. It is mainly about a wife’s unexpected response to the news of her husband's death. In this paper, the plot, main characters, and conflicts will first be illustrated, and the author will analyze this story from feminist approaches. We see clearly that women in that time did not have the right to choose their own marriages, and the main character is just one of the victims.

  4. Work patterns, sleeping hours and excess weight in commercial drivers.

    Science.gov (United States)

    Lemke, M K; Hege, A; Perko, M; Sönmez, S; Apostolopoulos, Y

    2015-12-01

    Work and sleep patterns for commercial motor vehicle (CMV) drivers often include long working hours, shift work and diminished sleep duration and quality, which have been linked to overweight, obesity and other problems. To explore possible connections between work, sleep and obesity among CMV drivers. Survey and anthropometric data were collected from male long-haul CMV drivers in central North Carolina, USA, over a period of 6 months. Drivers' body mass index (BMI) was used as a measure of total body obesity and sagittal abdominal diameter (SAD) as a measure of central adiposity. Among the 260 study subjects, mean BMI was 33.1 (64% were obese or morbidly obese) and mean SAD was 32.3cm, classifying 89% of drivers as being at high or very high cardiometabolic risk. About 83% of drivers worked an irregular daily schedule, 64% worked irregular total daily hours, 32% worked irregular days of the week and 46% reported getting work nights. Significant predictors of BMI included the number of hours worked daily (P work (P Work and sleep configurations appear to affect the weight status of CMV drivers. Shift work and sleep duration are both associated with the weight status of CMV drivers, and both appear to function as indicators of their sleep quality. © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Prediction of outcome in neurogenic oropharyngeal dysphagia within 72 hours of acute stroke.

    Science.gov (United States)

    Ickenstein, Guntram W; Höhlig, Carolin; Prosiegel, Mario; Koch, Horst; Dziewas, Rainer; Bodechtel, Ulf; Müller, Rainer; Reichmann, Heinz; Riecker, Axel

    2012-10-01

    Stroke is the most frequent cause of neurogenic oropharyngeal dysphagia (NOD). In the acute phase of stroke, the frequency of NOD is greater than 50% and, half of this patient population return to good swallowing within 14 days while the other half develop chronic dysphagia. Because dysphagia leads to aspiration pneumonia, malnutrition, and in-hospital mortality, it is important to pay attention to swallowing problems. The question arises if a prediction of severe chronic dysphagia is possible within the first 72 hours of acute stroke. On admission to the stroke unit, all stroke patients were screened for swallowing problems by the nursing staff within 2 hours. Patients showing signs of aspiration were included in the study (n = 114) and were given a clinical swallowing examination (CSE) by the swallowing/speech therapist within 24 hours and a swallowing endoscopy within 72 hours by the physician. The primary outcome of the study was the functional communication measure (FCM) of swallowing (score 1-3, tube feeding dependency) on day 90. The grading system with the FCM swallowing and the penetration-aspiration scale (PAS) in the first 72 hours was tested in a multivariate analysis for its predictive value for tube feeding-dependency on day 90. For the FCM level 1 to 3 (P dysphagia scales to prevent aspiration pneumonia and malnutrition. A dysphagia program can lead to better communication within the stroke unit team to initiate the appropriate diagnostics and swallowing therapy as soon as possible. Copyright © 2012 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  6. PLASMA VOLUME EXPANSION 24-HOURS POST-EXERCISE: EFFECT OF DOUBLING THE VOLUME OF REPLACEMENT FLUID

    Directory of Open Access Journals (Sweden)

    Bartholomew Kay

    2005-06-01

    Full Text Available The effects of two volumes (1.5 L or 3.0 L of commercially available electrolyte beverage (1.44 mM·L-1 Na+ taken during a 24-hour recovery period post-exercise, on plasma volume (PV expansion 24-hours post-exercise were assessed. A simple random-order crossover research design was used. Subjects (n = 9 males: age 21 ± 4 years, body mass 80.0 ± 9.0 kg, peak incremental 60-second cycling power output 297 ± 45 W [means ± SD] completed an identical exercise protocol conducted in hot ambient conditions (35oC, 50% relative humidity on two occasions; separated by 7-days. On each occasion, subjects received a different volume of 24-hour fluid intake (commercial beverage in random order. In each case, the fluid was taken in five equal aliquots over 24-hours. PV expansions 24-hours post-exercise were estimated from changes in haemoglobin and haematocrit. Dependent t-testing revealed no significant differences in PV expansions between trials, however a significant expansion with respect to zero was identified in the 3.0 L trial only. Specifically, PV expansions (% were; 1.5 L trial: (mean ± SE 2.3 ± 2.0 (not significant with respect to zero, 3.0 L trial: 5.0 ± 2.0 (p < 0.05, with respect to zero. Under the conditions imposed in the current study, ingesting the greater volume of the beverage lead to larger mean PV expansion

  7. The Effect of Closing Hour Restrictions on Alcohol Use and Abuse in Russia

    Directory of Open Access Journals (Sweden)

    Alexander S. Skorobogatov

    2016-09-01

    Full Text Available Since 2006 onward various regions have been putting and toughening local regulations for alcohol sale hours. The effect of these policies is uncertain in a specific social and economic environment featured by poor observance of the law; long tradition of the excessive consumption of strong spirits; and significant supply of home-made or surrogate alcoholic beverages. This paper uses on the data from the RLMS for 2005-2012 to discuss the effect of the restriction of trading hours on the use of alcoholic beverages falling under the restriction, as well as the substitution effect for the beverages not under the restriction. The adult respondents were broken into the treatment group and control group assuming that the former was more sensitive to the hour restriction. The hypotheses tested are that these policies decrease the use of factory-made vodka and increase the use of home-made vodka (samogon and factory-made light beverages. Overall use, binge drinking, and the consumption of vodka, samogon, beer, and wine were examined. The paper discusses the existing estimates of the econometric specification difference-in-differences designed for testing the hypotheses. The conclusions are that the sales restrictions led to a decrease of factory-made vodka consumption and its partial substitution by samogon for people most exposed to the restriction.

  8. Duty hours as viewed through a professionalism lens

    Science.gov (United States)

    2014-01-01

    Understanding medical professionalism and its evaluation is essential to ensuring that physicians graduate with the requisite knowledge and skills in this domain. It is important to consider the context in which behaviours occur, along with tensions between competing values and the individual’s approach to resolving such conflicts. However, too much emphasis on behaviours can be misleading, as they may not reflect underlying attitudes or professionalism in general. The same behaviour can be viewed and evaluated quite differently, depending on the situation. These concepts are explored and illustrated in this paper in the context of duty hour regulations. The regulation of duty hours creates many conflicts that must be resolved, and yet their resolution is often hidden, especially when compliance with or violation of regulations carries significant consequences. This article challenges attending physicians and the medical education community to reflect on what we value in our trainees and the attributions we make regarding their behaviours. To fully support our trainees’ development as professionals, we must create opportunities to teach them the valuable skills they will need to achieve balance in their lives. [P]rofessionalism has no meaningful existence independent of the interactions that give it form and meaning. There is great folly in thinking otherwise. Hafferty and Levinson (2008)[1] Understanding and evaluating professionalism is essential to excellence in medical education and is mandated by organizations that oversee medical training [2]. Historically, attention has been focused largely on the professionalism of individual students or residents, at least for the purposes of evaluation. Yet there is now a growing appreciation that professionalism can be defined, understood, and evaluated from multiple perspectives [3]. Importantly, context has been recognized as critical to shaping trainees’ behaviours, and hence as important to our understanding of

  9. Disaggregation of Rainy Hours: Compared Performance of Various Models.

    Science.gov (United States)

    Ben Haha, M.; Hingray, B.; Musy, A.

    In the urban environment, the response times of catchments are usually short. To de- sign or to diagnose waterworks in that context, it is necessary to describe rainfall events with a good time resolution: a 10mn time step is often necessary. Such in- formation is not always available. Rainfall disaggregation models have thus to be applied to produce from rough rainfall data that short time resolution information. The communication will present the performance obtained with several rainfall dis- aggregation models that allow for the disaggregation of rainy hours into six 10mn rainfall amounts. The ability of the models to reproduce some statistical character- istics of rainfall (mean, variance, overall distribution of 10mn-rainfall amounts; ex- treme values of maximal rainfall amounts over different durations) is evaluated thanks to different graphical and numerical criteria. The performance of simple models pre- sented in some scientific papers or developed in the Hydram laboratory as well as the performance of more sophisticated ones is compared with the performance of the basic constant disaggregation model. The compared models are either deterministic or stochastic; for some of them the disaggregation is based on scaling properties of rainfall. The compared models are in increasing complexity order: constant model, linear model (Ben Haha, 2001), Ormsbee Deterministic model (Ormsbee, 1989), Ar- tificial Neuronal Network based model (Burian et al. 2000), Hydram Stochastic 1 and Hydram Stochastic 2 (Ben Haha, 2001), Multiplicative Cascade based model (Olsson and Berndtsson, 1998), Ormsbee Stochastic model (Ormsbee, 1989). The 625 rainy hours used for that evaluation (with a hourly rainfall amount greater than 5mm) were extracted from the 21 years chronological rainfall series (10mn time step) observed at the Pully meteorological station, Switzerland. The models were also evaluated when applied to different rainfall classes depending on the season first and on the

  10. OPERATIONS THROUGHPUT AS A DETERMINANT OF GOLDEN-HOUR IN MASS-GATHERING MEDICINE

    Directory of Open Access Journals (Sweden)

    I. D. Khan

    2017-07-01

    Full Text Available BACKGROUND Golden-hour, a time-tested concept for trauma-care, involves a systems approach encompassing healthcare, logistics, geographical, environmental and temporal variables. Golden-hour paradigm in mass-gathering-medicine such as the Hajj-pilgrimage entwines along healthcare availability, accessibility, efficiency and interoperability; expanding from the patient-centric to public-health centric approach. The realm of mass-gathering-medicine invokes an opportunity for incorporating operations-throughput as a determinant of golden-hour for overall capacity-building and interoperability. METHODS Golden-hour was evaluated during the Indian-Medical-Mission operations for Hajj-2016; which established, operated and coordinated a strategic network of round-the-clock medical operations. Throughput was evaluated as deliverables/time, against established Standard-Operating-Procedures for various clinical, investigation, drug-dispensing and patient-transfer algorithms. Patient encounter-time, waiting-time, turnaround-time were assessed throughout echeloned healthcare under a patient-centric healthcare-delivery model. Dynamic evaluation was carried out to cater for variation and heterogeneity. RESULTS Massive surge of 3,94,013 patients comprising 2,25,103 males (57.1% and 1,68,910 females (42.9% overwhelmed the throughput capacities of outpatient attendance, pharmacy, laboratory, imaging, ambulance, referrals and documentation. There was delay in attendance, suspicion, diagnosis and isolation of patients with communicable infections. The situational-analysis of operations-throughput highlights wasted turnaround-time due to mobilization of medical-team, diverting critical healthcare resources away from emergency situations. CONCLUSION Time being a crucial factor in the complexity of medical-care, operations-throughput remains an important determinant towards interoperability of bottlenecks, thereby being a determinant of golden-hour in mass

  11. Detection of vancomycin resistances in enterococci within 3 1/2 hours

    Science.gov (United States)

    Schröder, U. -Ch.; Beleites, C.; Assmann, C.; Glaser, U.; Hübner, U.; Pfister, W.; Fritzsche, W.; Popp, J.; Neugebauer, U.

    2015-02-01

    Vancomycin resistant enterococci (VRE) constitute a challenging problem in health care institutions worldwide. Novel methods to rapidly identify resistances are highly required to ensure an early start of tailored therapy and to prevent further spread of the bacteria. Here, a spectroscopy-based rapid test is presented that reveals resistances of enterococci towards vancomycin within 3.5 hours. Without any specific knowledge on the strain, VRE can be recognized with high accuracy in two different enterococci species. By means of dielectrophoresis, bacteria are directly captured from dilute suspensions, making sample preparation very easy. Raman spectroscopic analysis of the trapped bacteria over a time span of two hours in absence and presence of antibiotics reveals characteristic differences in the molecular response of sensitive as well as resistant Enterococcus faecalis and Enterococcus faecium. Furthermore, the spectroscopic fingerprints provide an indication on the mechanisms of induced resistance in VRE.

  12. The 88-hour family: effects of the 80-hour work week on marriage and childbirth in a surgical residency.

    Science.gov (United States)

    Jones, Arden M; Jones, Kevin B

    2007-01-01

    The restriction of the resident physician work week to 80 hours has had dramatic affects on resident education and life-style. While effects on mood, psychological distress, and burn-out have been studied, the resultant changes in tangible quality of life have received little attention. Birth rate was considered a measurable, relevant outcome. The resident marital and parental status by duty month was collected from a single orthopaedic surgical residency program for the four academic years preceding and following the implementation of the 80-hour work week. The number of births to residents during these periods were also tallied. The relative prevalence of positive marital status changed very little between residents in the two time durations from 66 to 71 percent, but parental status increased from 27 to 43 percent. The number of births per married resident duty year also increased from 0.23 pre-restrictions to 0.32 post-restrictions. While the individual decisions involved in generating these observed changes are complex and difficult to entirely decipher, it is thought that an increased perception of life-control within the work-hour restrictions may have prompted the dramatic changes in birth rate among resident families.

  13. A model of human sleep-related growth hormone secretion in dogs: effects of 3, 6, and 12 hours of forced wakefulness on plasma growth hormone, cortisol, and sleep stages.

    Science.gov (United States)

    Takahashi, Y; Ebihara, S; Nakamura, Y; Takahashi, K

    1981-07-01

    Twenty-four canine GH (cGH) and cortisol secretion patterns associated with sleep stages were studied in 10 male adult dogs. Plasma samples were obtained at 30- or 15-min intervals via an indwelling catheter. Under baseline conditions, all dogs showed irregular polyphasic sleep, and the episodic cGH secretion had no apparent relationship with sleep or the light-dark cycle. Five dogs were subjected to regular sleep-wake cycles; 3, 6, and 12 h of forced wakefulness (FW) were repeated at 3-, 6-, and 12-h intervals (recovery sleep periods), respectively. Peak cGH secretion (mean +/- SD, 6.4 ng/ml +/- 2.4) occurred soon after recovery sleep onset in 25 of 40 total recovery periods. The incidence of sleep-onset cGH peaks and cGH secretion during the first hour of recovery sleep significantly increased with the length of the preceding FW, but were not affected by the time of day. Delta wave sleep increased during this hour, suggesting a possible correlation with the sleep-onset cGH peak. During the first 3 h of recovery after 6 and 12 h of FW, cGH secretion was significantly enhanced, but cortisol was not. Considering the characteristics of human sleep-related GH secretion, we suggest that this peak cGH secretion represents a model of human GH secretion. Possibly, a close association of cGH secretion with sleep is concealed under the baseline condition and uncovered by inducing longer sleep-wake cycles in dogs. No circadian cortisol variation was detected under the baseline or the experimental conditions.

  14. Health and psychosocial effects of flexible working hours

    Directory of Open Access Journals (Sweden)

    Daniela Janssen

    2004-12-01

    Full Text Available OBJECTIVE: To examine whether any impairments in health and social lives can be found under different kinds of flexible working hours, and whether such effects are related to specific characteristics of these working hours. METHODS: Two studies - a company based survey (N=660 and an internet survey (N=528 - have been conducted. The first one was a questionnaire study (paper and pencil on employees working under some 'typical' kinds of different flexible working time arrangements in different companies and different occupational fields (health care, manufacturing, retail, administration, call centres. The second study was an internet-based survey, using an adaptation of the questionnaire from the first study. RESULTS: The results of both studies consistently show that high variability of working hours is associated with increased impairments in health and well-being and this is especially true if this variability is company controlled. These effects are less pronounced if variability is self-controlled; however, autonomy does not compensate the effects of variability. CONCLUSIONS: Recommendations for an appropriate design of flexible working hours should be developed in order to minimize any impairing effects on health and psychosocial well-being; these recommendations should include - besides allowing for discretion in controlling one's (flexible working hours - that variability in flexible working hours should be kept low (or at least moderate, even if this variability is self-controlled.OBJETIVO: Investigar se ocorre prejuízo à saúde e à vida social com diferentes tipos de horas de trabalho flexíveis e se há relação entre estes efeitos e características específicas das horas de trabalho. MÉTODOS: Foram realizados dois estudos, uma pesquisa em uma empresa (N=660 e outra pela Internet (N=528. O primeiro estudo consistiu de um questionário (papel e lápis aplicado a funcionários sujeitos a diferentes ajustes "típicos" de horas de

  15. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth

    Science.gov (United States)

    Li, Shanshan; Guo, Yuming; Williams, Gail

    2016-01-01

    Background: Preterm birth is a major perinatal health problem, but factors leading to it are still not completely understood. Objectives: Our goal was to identify the relation between acute increase in ambient air pollution in a few hours before onset of labor and the risk of preterm birth. Methods: We collected registered birth outcome data and hourly ambient air pollution measurements during 2009‒2013 in Brisbane, Australia. Using a time-stratified case-crossover design and conditional logistic regression models with natural cubic splines, we assessed the shape of air pollution-preterm birth curve, after controlling for potential confounders. We also examined the effect modification of other factors. Results: The association between air pollution [nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)] and preterm birth was nonlinear. Threshold concentrations for the mean of 0‒24 hr NO2, 24‒48 hr SO2, and 24‒48 hr CO before onset of labor were 7.6 parts per billion (ppb), 3.8 ppb, and 162.5 ppb, respectively. Increases in air pollution concentrations above thresholds were associated with increased risks of preterm birth. The odds ratios of preterm birth at the 95th percentile of NO2, SO2, and CO against the thresholds were 1.17 (95% CI: 1.08, 1.27), 1.01 (95% CI: 0.99, 1.04), and 1.18 (95% CI: 1.06, 1.32), respectively. The associations were modified by demographic factors, such as maternal smoking and socioeconomic status. Conclusion: Acute increases in ambient air pollution concentrations above certain levels before onset of labor may stimulate preterm birth. Citation: Li S, Guo Y, Williams G. 2016. Acute impact of hourly ambient air pollution on preterm birth. Environ Health Perspect 124:1623–1629; http://dx.doi.org/10.1289/EHP200 PMID:27128028

  16. Hourly weather forecasts for gas turbine power generation

    Directory of Open Access Journals (Sweden)

    G. Giunta

    2017-06-01

    Full Text Available An hourly short-term weather forecast can optimize processes in Combined Cycle Gas Turbine (CCGT plants by helping to reduce imbalance charges on the national power grid. Consequently, a reliable meteorological prediction for a given power plant is crucial for obtaining competitive prices for the electric market, better planning and stock management, sales and supplies of energy sources. The paper discusses the short-term hourly temperature forecasts, at lead time day+1 and day+2, over a period of thirteen months in 2012 and 2013 for six Italian CCGT power plants of 390 MW each (260 MW from the gas turbine and 130 MW from the steam turbine. These CCGT plants are placed in three different Italian climate areas: the Po Valley, the Adriatic coast, and the North Tyrrhenian coast. The meteorological model applied in this study is the eni-Kassandra Meteo Forecast (e‑kmf™, a multi-model approach system to provide probabilistic forecasts with a Kalman filter used to improve accuracy of local temperature predictions. Performance skill scores, computed by the output data of the meteorological model, are compared with local observations, and used to evaluate forecast reliability. In the study, the approach has shown good overall scores encompassing more than 50,000 hourly temperature values. Some differences from one site to another, due to local meteorological phenomena, can affect the short-term forecast performance, with consequent impacts on gas-to-power production and related negative imbalances. For operational application of the methodology in CCGT power plant, the benefits and limits have been successfully identified.

  17. Provisional hourly values of equatorial Dst for 1971

    Science.gov (United States)

    Sugiura, M.; Poros, D. J.

    1972-01-01

    Tables and plots of provisional hourly values of the equatorial Dst index for 1971 are given, a table of daily mean Dst values for 1971 is also provided. The base line values for the four observatories, Hermanus, Kakioka, Honolulu, and San Juan, were obtained from extrapolations using the coefficients for the secular variations determined for the previous years. Examining the Dst values for quiet days, the base lines so determined appear to be slightly low, so that the Dst index for quiet periods tends to be high.

  18. Twenty-three hour recovery: observation versus hospitalization.

    Science.gov (United States)

    Clement, P; Sangermano, C

    1992-10-01

    In the wake of the rapidly changing health care delivery environment, it is becoming essential to health care organizations that unique, innovative methods of managing resources be implemented. Further, such developments must be achieved within the confines of those requirements and revisions occurring within the reimbursement structures of Medicare and Medicaid as well as other third-party payors in keeping with the delivery of quality patient care. The evaluation of patients in an outpatient environment for a period of time before a final decision regarding disposition is made creates the "observation concept." This article discusses the significance of 23-hour observation units for ambulatory surgery patients.

  19. LinkedIn Marketing An Hour a Day

    CERN Document Server

    von Rosen, Viveka

    2012-01-01

    A step-by-step guide for succeeding on the for ''business'' social media network LinkedIn Marketing: An Hour a Day helps you create, customize, and optimize a presence on LinkedIn, the world's largest social network for professionals. In this detailed, step-by-step book, LinkedIn expert Viveka von Rosen reveals how to use this powerful platform to ensure that you or your company get noticed by the right audience. Discover previously undocumented tips and tricks for community growth and management, including how to best use Groups, events, and other LinkedIn features and applications. Offers a

  20. Penile Replantation After Five Hours of Warm Ischemia

    Directory of Open Access Journals (Sweden)

    Fernando N. Facio Jr.

    2015-05-01

    Full Text Available Although a rare occurrence, this event may occur as a result of self-mutilation among individuals with psychiatric disturbances or due to work-related accidents, iatrogenic injuries or the actions of individuals motivated by jealously, rage and feelings of betrayal. In western societies, most penile amputations are the result of self-aggression during a psychotic episode, the treatment of victims involves resuscitation, stabilization and immediate psychiatric support. The amputated tissue must be preserved under hypothermic conditions. Micro-surgery is currently the most widely employed method for penile replantation. This paper describes a successful case of penile replantation following 5 hours of warm ischemia.

  1. Global solar radiation estimation from relative sunshine hours in Yemen

    Energy Technology Data Exchange (ETDEWEB)

    Abdul-Aziz, J.; A-Nagi, A.; Zumailan, A.A.R. (Aden Univ. (Yemen, Republic of))

    1993-01-01

    The existing measurements of global solar radiation and sunshine duration for Yemen are examined. The errors of estimating global solar radiation from sunshine hour measurements using Angstrom's relation are evaluated. As a simple predictor for global solar radiation, an average Angstrom relation in the form H-bar/H[sub o] = 0.3518 + 0.3162 n/N for all stations is evaluated. Other Angstrom correlation relations are also proposed by classifying the stations under study into four groups. The estimated results are compared and seem to be satisfactory in the latter case. (Author)

  2. Hourly resolved cloud modification factors in the ultraviolet

    Directory of Open Access Journals (Sweden)

    H. Staiger

    2008-01-01

    Full Text Available Cloud impacts on the transfer of Ultraviolet (UV radiation through the atmosphere can be assessed using a cloud modification factor (CMF. The total global solar irradiation has proven to be a solid basis to derive CMF's for the UV radiation (UV_CMF. Total global irradiance is frequently measured and forecasted by numerical weather prediction systems. Its advantage compared to for instance cloud cover is that measured solar global irradiance contains already the effect of multiple reflection between cloud layers, reflection between the sides of the clouds, as well as the distinct difference whether the solar disc is obscured by clouds or not. In the UV range clouds decrease the irradiance to a lesser extent than in the visible and infrared spectral range; Rayleigh scattering in the atmosphere yields a larger fraction of scatter radiation compared to that of light and infrared, hence, obscuring the solar disc will not totally block out the irradiation. Thus the relationship between CMF's for solar radiation and for UV-radiation is not straight forwards, but will depend on e.g. the solar zenith angle (SZA and wavelength band or action spectrum in the UV considered. Den Outer et al. (2005 provide a UV_CMF algorithm on a daily base accounting for these influences. It requires as input a daily CMF in total global radiation (SOL_CMF and the SZA at noon. The calculation of SOL-CMF uses the clear sky algorithm of the European Solar Radiation Atlas to account for varying turbidity impacts. The algorithm's capability to derive hourly UV_CMF's based on the SZA at the corresponding hour and its worldwide applicability is validated using hourly resolved observational data retrieved from the databases of the COST-Action 726 on "Long term changes and climatology of UV radiation over Europe" and the USDA UV-B Monitoring and Research Program. The model performance for hourly resolution is shown to be comparable in absolute and relative

  3. Development of a Stochastic Hourly Solar Irradiation Model

    Directory of Open Access Journals (Sweden)

    Kristijan Brecl

    2014-01-01

    Full Text Available We have developed a new solar irradiation model and implemented it in the SunIrradiance photovoltaic cell/module simulator. This model uses stochastic methods to generate the hourly distribution of solar irradiation on a horizontal or inclined surface from monthly irradiation values on the horizontal surface of a selected location and was verified with the measured irradiance data in Ljubljana, located in Central Europe. The new model shows better simulation results with regard to the share of the diffuse irradiation in the region than the other models. The simulation results show that the new solar irradiation model is excellent for photovoltaic system simulations of single junction PV technologies.

  4. Eleventh Hour Network+ Exam N10-004 Study Guide

    CERN Document Server

    Alpern, Naomi

    2009-01-01

    The 11th Hour Network+ Study Guide is keyed to the N10-004 revision of the CompTIA Network+ exam. This book is streamlined to include only core certification information and is presented for ease of last-minute studying. Main objectives of the exam are covered with key concepts highlighted. ..: ..; Fast Facts quickly review fundamentals ..; Exam Warnings highlight particularly tough sections of the exam ..; Crunch Time sidebars point out key concepts to remember ..; Did You Know? sidebars cover sometimes forgotten details ..; Top Five Toughest Questions and answers help you to prepare ..

  5. Off-hours admission and quality of hip fracture care

    DEFF Research Database (Denmark)

    Kristiansen, Nina Sahlertz; Kristensen, Pia Kjær; Nørgård, Bente Mertz

    2016-01-01

    OBJECTIVE: Higher risks of adverse outcomes have been reported for patients admitted acutely during off-hours. However, in relation to hip fracture, the evidence is inconsistent. We examined whether time of admission influenced compliance with performance measures, surgical delay and 30-day...... mortality in patients with hip fracture. DESIGN: Cohort study. SETTING: Data from The Danish Multidisciplinary Hip Fracture Registry linked with data from Danish National Registries. PARTICIPANTS: Danish patients undergoing hip fracture surgery, aged >65 years, admitted 1 March 2010 to 30 November 2013 (N...

  6. Rosetta Mission's "7 Hours of Terror" and Philae's Descent

    Science.gov (United States)

    Blanco, Philip

    2015-09-01

    In November 2014 the Rosetta mission to Comet 67P/Churyumov-Gerasimenko made the headlines when its Philae lander completed a successful unpowered descent onto the surface of the comet nucleus after "7 hours of terror" for the mission scientists. 67P's irregular shape and rotation made this task even more challenging. Philae fell almost radially towards 67P, as shown in an animation produced by the European Space Agency (ESA) prior to the event. Below, we investigate whether it is possible to model the spacecraft's descent time and impact speed using concepts taught in an introductory physics course.

  7. Analysis of the Story of an Hour from Feminist Approaches

    Institute of Scientific and Technical Information of China (English)

    任立立

    2014-01-01

    The Story of an Hour is a short story written by Kate Chopin in 1894. It is mainly about a wife’s unexpected response to the news of her husband’s death. In this paper, the plot, main characters, and conflicts will first be illustrated, and the author will analyze this story from feminist approaches. We see clearly that women in that time did not have the right to choose their own marriages, and the main character is just one of the victims.

  8. Predicting medical specialists’ working (long) hours: testing a contemporary career model

    NARCIS (Netherlands)

    Pas, B.R.; Eisinga, R.; Doorewaard, J.A.C.M.

    2016-01-01

    With the feminization (in numbers) of several professions, changing gender role prescriptions regarding parenthood and an increased attention for work-life balance, career theorists recently addressed the need for a more contemporary career model taking a work–home perspective. In this study, we tes

  9. Predicting medical specialists' working (long) hours: Testing a contemporary career model

    NARCIS (Netherlands)

    Pas, B.R.; Eisinga, R.N.; Doorewaard, J.A.C.M.

    2016-01-01

    With the feminization (in numbers) of several professions, changing gender role prescriptions regarding parenthood and an increased attention for work-life balance, career theorists recently addressed the need for a more contemporary career model taking a work-home perspective. In this study, we tes

  10. Predicting medical specialists' working (long) hours: Testing a contemporary career model

    NARCIS (Netherlands)

    Pas, B.R.; Eisinga, R.N.; Doorewaard, J.A.C.M.

    2016-01-01

    With the feminization (in numbers) of several professions, changing gender role prescriptions regarding parenthood and an increased attention for work-life balance, career theorists recently addressed the need for a more contemporary career model taking a work-home perspective. In this study, we

  11. Predicting medical specialists’ working (long) hours: Testing a contemporary career model

    NARCIS (Netherlands)

    Pas, B.R.; Eisinga, R.; Doorewaard, J.A.C.M.

    2016-01-01

    With the feminization (in numbers) of several professions, changing gender role prescriptions regarding parenthood and an increased attention for work-life balance, career theorists recently addressed the need for a more contemporary career model taking a work–home perspective. In this study, we

  12. Forecasting geomagnetic activity three hours in advance for ionospheric applications

    Energy Technology Data Exchange (ETDEWEB)

    De Franceschi, G.; Perrone, L. [Istituto Nazionale di Geofisica e Vulcanologia, Rome (Italy); Gulyaeva, T. L. [Russian Academy of Sciences, Institute of Terrestrial Magnetism, Ionosphere and Radiowave Propagation, Moscow (Russian Federation); Space Research Centre, Warsaw (Poland)

    2001-12-01

    An attempt at forecasting the magnetic activity index three hours in advance is presented. This approach is based on a suitable treatment of time-weighted accumulations of the three-hourly magnetic index Kp. The statistical analysis of impact of magnetic activity on the positive and negative disturbances of the F{sub 2} layer peak electron density NmF{sub 2} is made for 25 ionosondes in Europe and Russia during 1997 to 2001. It is shown that the response of positive and negative ionosphere disturbances to peak of magnetic activity Kpmax delays by 1 to 48 h. Two peaks of occurrence of positive and negative ionospheric disturbed periods are found referring to Kpmax equal to 3 and 4 for DNmF{sub 2}+ and Kpmax equal to 4 and 5 for DNmF{sub 2}- shifted regarding similar distribution of forecasted Kpm indices depicting two maxima at Kp equal to 1.7 and 2.7. Comparisons are made with observations and IRI-2001 model predictions.

  13. Ex Situ Perfusion of Human Limb Allografts for 24 Hours.

    Science.gov (United States)

    Werner, Nicole L; Alghanem, Fares; Rakestraw, Stephanie L; Sarver, Dylan C; Nicely, Bruce; Pietroski, Richard E; Lange, Paul; Rudich, Steven M; Mendias, Christopher L; Rojas-Pena, Alvaro; Magee, John C; Bartlett, Robert H; Ozer, Kagan

    2017-03-01

    Vascularized composite allografts, particularly hand and forearm, have limited ischemic tolerance after procurement. In bilateral hand transplantations, this demands a 2 team approach and expedited transfer of the allograft, limiting the recovery to a small geographic area. Ex situ perfusion may be an alternative allograft preservation method to extend allograft survival time. This is a short report of 5 human limbs maintained for 24 hours with ex situ perfusion. Upper limbs were procured from brain-dead organ donors. Following recovery, the brachial artery was cannulated and flushed with 10 000 U of heparin. The limb was then attached to a custom-made, near-normothermic (30-33°C) ex situ perfusion system composed of a pump, reservoir, and oxygenator. Perfusate was plasma-based with a hemoglobin concentration of 4 to 6 g/dL. Average warm ischemia time was 76 minutes. Perfusion was maintained at an average systolic pressure of 93 ± 2 mm Hg, flow 310 ± 20 mL/min, and vascular resistance 153 ± 16 mm Hg/L per minute. Average oxygen consumption was 1.1 ± 0.2 mL/kg per minute. Neuromuscular electrical stimulation continually displayed contraction until the end of perfusion, and histology showed no myocyte injury. Human limb allografts appeared viable after 24 hours of near-normothermic ex situ perfusion. Although these results are early and need validation with transplantation, this technology has promise for extending allograft storage times.

  14. Hybrid methodology for hourly global radiation forecasting in Mediterranean area

    CERN Document Server

    Voyant, Cyril; Paoli, Christophe; Nivet, Marie Laure

    2012-01-01

    The renewable energies prediction and particularly global radiation forecasting is a challenge studied by a growing number of research teams. This paper proposes an original technique to model the insolation time series based on combining Artificial Neural Network (ANN) and Auto-Regressive and Moving Average (ARMA) model. While ANN by its non-linear nature is effective to predict cloudy days, ARMA techniques are more dedicated to sunny days without cloud occurrences. Thus, three hybrids models are suggested: the first proposes simply to use ARMA for 6 months in spring and summer and to use an optimized ANN for the other part of the year; the second model is equivalent to the first but with a seasonal learning; the last model depends on the error occurred the previous hour. These models were used to forecast the hourly global radiation for five places in Mediterranean area. The forecasting performance was compared among several models: the 3 above mentioned models, the best ANN and ARMA for each location. In t...

  15. Reviewing 741 patients records in two hours with FASTVISU

    Science.gov (United States)

    Escudié, Jean-Baptiste; Jannot, Anne-Sophie; Zapletal, Eric; Cohen, Sarah; Malamut, Georgia; Burgun, Anita; Rance, Bastien

    2015-01-01

    The secondary use of electronic health records opens up new perspectives. They provide researchers with structured data and unstructured data, including free text reports. Many applications been developed to leverage knowledge from free-text reports, but manual review of documents is still a complex process. We developed FASTVISU a web-based application to assist clinicians in reviewing documents. We used FASTVISU to review a set of 6340 documents from 741 patients suffering from the celiac disease. A first automated selection pruned the original set to 847 documents from 276 patients’ records. The records were reviewed by two trained physicians to identify the presence of 15 auto-immune diseases. It took respectively two hours and two hours and a half to evaluate the entire corpus. Inter-annotator agreement was high (Cohen’s kappa at 0.89). FASTVISU is a user-friendly modular solution to validate entities extracted by NLP methods from free-text documents stored in clinical data warehouses. PMID:26958189

  16. Effect of hyperthermia given four hours after irradiation on late damage in mouse legs

    Energy Technology Data Exchange (ETDEWEB)

    Harding R.P.

    1985-01-01

    The right hind legs of mice were treated with (1) radiation, (2) heat, or (3) radiation followed four hours later by heat. Leg contracture was measured at three, six and nine months after treatment and skin samples from the treated legs were excised for determination of hydroxyproline (i.e., collagen) and uronic acid content (i.e., ground substance) as a measure of fibrosis. The effect of pre-treatment administration of cobra venom factor (complement depletion) on these parameters was also tested. Following irradiation, considerable leg contracture, an increase in hydroxyproline content and a decrease in uronic acid concentration were observed. Following heat only, leg contracture, hydroxyproline and uronic acid content in skin were unaffected. When irradiation was followed four hours later by heat, leg contracture was delayed, reduced or enhanced compared to radiation only. In addition, collagen accumulation was delayed or unchanged by heat treatment, compared with radiation alone, without affecting the uronic acid content. Pre-irradiation administration of cobra venom factor (CVF) produced effects on leg contracture which were, in some cases, similar to those produced by heat treatment four hours after irradiation.

  17. An Hourly Streamflow Forecasting Model Coupled with an Enforced Learning Strategy

    Directory of Open Access Journals (Sweden)

    Ming-Chang Wu

    2015-10-01

    Full Text Available Floods, one of the most significant natural hazards, often result in loss of life and property. Accurate hourly streamflow forecasting is always a key issue in hydrology for flood hazard mitigation. To improve the performance of hourly streamflow forecasting, a methodology concerning the development of neural network (NN based models with an enforced learning strategy is proposed in this paper. Firstly, four different NNs, namely back propagation network (BPN, radial basis function network (RBFN, self-organizing map (SOM, and support vector machine (SVM, are used to construct streamflow forecasting models. Through the cross-validation test, NN-based models with superior performance in streamflow forecasting are detected. Then, an enforced learning strategy is developed to further improve the performance of the superior NN-based models, i.e., SOM and SVM in this study. Finally, the proposed flow forecasting model is obtained. Actual applications are conducted to demonstrate the potential of the proposed model. Moreover, comparison between the NN-based models with and without the enforced learning strategy is performed to evaluate the effect of the enforced learning strategy on model performance. The results indicate that the NN-based models with the enforced learning strategy indeed improve the accuracy of hourly streamflow forecasting. Hence, the presented methodology is expected to be helpful for developing improved NN-based streamflow forecasting models.

  18. Protection of horse ears against Simulid parasitism: Efficacy of a mammal semiochemical solution over 10hours.

    Science.gov (United States)

    Creton, Benjamin; Pageat, Patrick; Robejean, Myriam; Lafont-Lecuelle, Céline; Cozzi, Alessandro

    2016-08-30

    Hematophagous insects can be vectors of pathogens and cause significant economic loss in zootechnical production. Among biting insects, many dipteran species feed on horse blood. The black fly (Diptera: Simuliidae) group, is responsible for several disorders in horses and inflicts painful bites that lead to undesirable behaviours in horses, particularly when bites occur in sensitive areas such as the inner ear. A field study was conducted in a French equestrian center during which a semiochemical was applied on horses' ears to assess repellent efficacy against simulid infestation. During the first phase of the study, efficacy was evaluated over a one hour period. Then, during the second phase of the study, persistency of the effect was tested at 8, 9 and 10h after application. The results of the study's first phase showed 90% efficacy over one hour, with 121.5 insects found in control ears and 12 insects in treated ears (p=0.001). In the second phase of the study, a total amount of 411 insects were observed on control ears whereas only 2 insects were observed on treated ears (p<0.0001); the treatment remained over 98% effective up to 10hours after application. When using a slow release excipient, this semiochemical may offer at least 10h of protection against simulids. This safe, efficient, and long lasting protection could help horses and their owners to manage simulid parasitism. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Sensitivity and specificity of 24-hour urine chemistry levels for detecting elevated calcium oxalate and calcium phosphate supersaturation

    Science.gov (United States)

    Rossi, M. Adrian; Singer, Eric A; Golijanin, Dragan J; Monk, Rebeca D; Erturk, Erdal; Bushinsky, David A

    2008-01-01

    Objectives The gold standard for determining likelihood of calcium oxalate (CaOx) and calcium phosphate (CaPhos) stone formation in urine is supersaturation of CaOx and CaPhos. Our objective was to investigate whether traditional measurement of total calcium, oxalate and phosphate in a 24-hour urine collection is sufficiently sensitive and specific for detecting elevated supersaturation to preclude the more expensive supersaturation test. Methods We performed a retrospective review of 150 consecutive patients with nephrolithiasis who underwent measurement of CaOx supersaturation (CaOxSS) and CaPhos supersaturation (CaPhosSS), as well as total calcium, oxalate and phosphate in a 24-hour urine collection. We used various cut-off values to determine sensitivity and specificity of 24-hour urine measurements for detecting elevated CaOxSS and CaPhosSS. Results In men and women, the sensitivity of 24-hour calcium for detecting elevated CaOxSS was 71% and 79%, respectively; for oxalate, sensitivity was 59% and 36%, respectively. In men and women, the sensitivity of 24-hour calcium for detecting elevated CaPhosSS was 74% and 88%, respectively; for phosphate, sensitivity was 57% and 8%, respectively. In men and women, the specificity of 24-hour calcium for detecting elevated CaOxSS was 55% and 48%, respectively; it was 60% for detecting elevated CaPhosSS in both men and women. Conclusion Traditional 24-hour urine analysis is sensitive, but not specific, for detecting elevated CaOxSS and CaPhosSS. Most patients with abnormal 24-hour urine analysis have normal supersaturation, and treatment decisions based on traditional urine analysis would lead to overtreatment in these patients. PMID:18542745

  20. Seamless Hourly Rainfall Ensemble Forecasts for 0 - 10 days

    Science.gov (United States)

    Cooper, Shaun; Seed, Alan

    2014-05-01

    The Australian Bureau of Meteorology uses a number of Numerical Weather Prediction (NWP) models to generate deterministic rainfall forecasts over a range of lead-times, each with a different resolution in space and time and with different forecast domains. High resolution regional NWP models are used to generate forecasts for the first three days, and are typically more accurate than lower resolution Global NWP models that produce forecasts for longer lead times. Consequently, there is a requirement for a seamless forecast system that is able to blend the various NWP forecasts into a single forecast with a uniform resolution over the entire forecast period. NWP rainfall forecasts contain errors at scales that are significant for even large river basins, and ensemble hydrological prediction systems require ensembles of the order of 100 members, which is well beyond the size that can be generated by NWP ensemble systems. The idea, therefore, is to blend the NWP models in such a way that recognises the skill of the NWP at a particular scale and lead time and to use a stochastic model of forecast errors to perturb the blended deterministic forecast to generate a large ensemble. NWP uncertainties are scale and forecast lead time dependent, especially at long forecast lead times, and are characteristic to each model. By blending the models scale by scale it is possible to recognise the increased skill of the models at larger spatial scales and shorter lead times. The stochastic model is applied at each scale, adding increasingly more variability at smaller spatial scales, while preserving the space-time structure of rain. This process allows an ensemble to be generated by blending deterministic forecasts. Two NWP models from the Bureau, ACCESS-G (Global) (~40 km by ~40 km, 3 hourly out to 10 days) and ACCESS-R (Regional) (~12 km by ~12 km, 1 hourly out to 3 days), are downscaled and blended with the stochastic model to produce an ensemble of hourly forecasts out to 10

  1. Hourly resolved cloud modification factors in the ultraviolet

    Directory of Open Access Journals (Sweden)

    H. Staiger

    2008-05-01

    Full Text Available Cloud impacts on the transfer of ultraviolet (UV radiation through the atmosphere can be assessed by using a cloud modification factor (CMF. CMF, which is based on total global solar irradiation (SOLCMF, has proved to be a solid basis to derive CMFs for the UV radiation (UVCMF. This is an advantage, because total global irradiance, the basis for SOLCMF, is frequently measured and forecasted by numerical weather prediction systems and includes all relevant effects for radiation transmission, such as cloud optical depth, different cloud layers, multiple reflection, as well as the distinct difference as to whether the solar disc is obscured by clouds or not. In the UV range clouds decrease the irradiance to a lesser extent than in the visible and infrared spectral range. Thus the relationship between CMFs for solar radiation and for UV-radiation is not straight forward, but will depend on whether, for example, the solar zenith angle (SZA and wavelength band or action spectrum in the UV have been taken into consideration. Den Outer et al. provide a UVCMF algorithm on a daily basis, which accounts for these influences. It requires as input a daily SOLCMF and the SZA at noon. The calculation of SOLCMF uses the clear-sky algorithm of the European Solar Radiation Atlas to account for varying turbidity impacts. The algorithm's capability to derive hourly UVCMFs based on the SZA at the corresponding hour and its worldwide applicability is validated for erythemal UV using observational data retrieved from the databases of the COST-Action 726 on "Long-term changes and climatology of UV radiation over Europe" and the USDA UV-B Monitoring Program. The clear-sky part of the models has proved to be of good quality. Accumulated to daily doses it forms a tight cluster of points to the highest measured daily sums. All sky model performances for hourly resolution are shown to be

  2. Exercising in the Fasted State Reduced 24-Hour Energy Intake in Active Male Adults

    Directory of Open Access Journals (Sweden)

    Jessica L. Bachman

    2016-01-01

    Full Text Available The effect of fasting prior to morning exercise on 24-hour energy intake was examined using a randomized, counterbalanced design. Participants (12 active, white males, 20.8±3.0 years old, VO2max:   59.1±5.7 mL/kg/min fasted (NoBK or received breakfast (BK and then ran for 60 minutes at 60%  VO2max. All food was weighed and measured for 24 hours. Measures of blood glucose and hunger were collected at 5 time points. Respiratory quotient (RQ was measured during exercise. Generalized linear mixed models and paired sample t-tests examined differences between the conditions. Total 24-hour (BK: 19172±4542 kJ versus NoBK: 15312±4513 kJ; p<0.001 and evening (BK: 12265±4278 kJ versus NoBK: 10833±4065; p=0.039 energy intake and RQ (BK: 0.90±0.03 versus NoBK: 0.86±0.03; p<0.001 were significantly higher in BK than NoBK. Blood glucose was significantly higher in BK than NoBK before exercise (5.2±0.7 versus 4.5±0.6 mmol/L; p=0.025. Hunger was significantly lower for BK than NoBK before exercise, after exercise, and before lunch. Blood glucose and hunger were not associated with energy intake. Fasting before morning exercise decreased 24-hour energy intake and increased fat oxidation during exercise. Completing exercise in the morning in the fasted state may have implications for weight management.

  3. Do flexible alcohol trading hours reduce violence? A theory-based natural experiment in alcohol policy.

    Science.gov (United States)

    Humphreys, David K; Eisner, Manuel P

    2014-02-01

    Alcohol-related violence is a pressing public health concern. In 2005, the government of England and Wales took a controversial approach to preventing violence by removing restrictions on opening hours for alcohol outlets, thus increasing the availability of alcohol. The policy aimed to remove fixed closing times, which it claimed was contributing to urban violence occurring at peak closing times. It proposed to reduce violence and disorder by installing systems of 'staggered closing times'. This policy was criticised for overlooking established public health principles prioritising the control of alcohol availability in the prevention of alcohol-related harm. In this study, we treated the removal of trading hour restrictions as a natural experiment to test competing theoretical principles about the relationship between alcohol availability and violence. Our study took place in the City of Manchester over a four-year period 2004-2008. Detailed trading records for over 600 alcohol outlets were obtained, as were police records for all violent incidents. We found considerable variation in the implementation of extended trading hours across the city, which affected area-level exposure of changes in alcohol availability and staggered closing times. To isolate the effect of these changes on violence, we performed a dose-response analysis to examine whether improved staggering of closing hours (or increased alcohol availability) was associated with decreases in violence. We found no evidence to support the government-proposed hypothesis that staggered closing reduces violence. We also found no support for the alternative hypothesis; that increase alcohol availability would result in increased violence. This study provides an example of how better evidence can be generated from natural experiments by placing added emphasis on theory, causal mechanisms and implementation science.

  4. Drug prescriptions in Danish out-of-hours primary care

    DEFF Research Database (Denmark)

    Christensen, Morten Bondo; Nørøxe, Karen Busk; Moth, Grete

    2016-01-01

    OBJECTIVE: General practitioners are the first point of contact in Danish out-of-hours (OOH) primary care. The large number of contacts implies that prescribing behaviour may have considerable impact on health-care expenditures and quality of care. The aim of this study was to examine...... the prevailing practices for medication prescription in Danish OOH with a particular focus on patient characteristics and contact type. DESIGN AND SETTING: A one-year population-based retrospective observational study was performed of all contacts to OOH primary care in the Central Denmark Region using registry...... data. MAIN OUTCOME MEASURES: Prescriptions were categorised according to Anatomical Therapeutic Chemical Classification (ATC) codes and stratified for patient age, gender and contact type (telephone consultation, clinic consultation or home visit). Prescription rates were calculated as number...

  5. Off-Hours Admission and Acute Stroke Care Quality

    DEFF Research Database (Denmark)

    Kristiansen, Nina Sahlertz; Mainz, Jan; Nørgård, Bente Mertz;

    2014-01-01

    stroke care processes, including the effect of a systematic quality improvement program, and to examine 30 days case-fatality. Methods-A population-based historical cohort study, including patients admitted to Danish hospitals with a first ever acute stroke (January 1, 2003, to December 31, 2011; N=64...... characteristics (in particular, stroke severity) decreased the odds ratio to 1.03 (95% confidence interval, 0.97-1.10). Additional adjustment for hospital characteristics and compliance with performance measures had no effect on the odds ratio. Conclusion-Patients admitted off-hours received a poorer quality...... of care. However, the admission time-related differences in care were substantially reduced over time, and the differences in 30 days case-fatality appeared primarily to be explained by differences in stroke severity....

  6. Noninvasive 24-hour ambulatory arterial blood pressure monitoring in cirrhosis

    DEFF Research Database (Denmark)

    Møller, Søren; Wiinberg, N; Henriksen, Jens Henrik

    1995-01-01

    Cirrhotic patients have disturbed systemic hemodynamics with reduced arterial blood pressure, but this has not been investigated during daily activity and sleep. Systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MAP), and heart rate (HR) were measured by an automatic ambulant...... device for monitoring blood pressure in 35 patients with cirrhosis and 35 healthy matched controls. During the daytime, SBP, DBP, and MAP were significantly lower in the patients than in the controls (median 118 vs. 127; 70 vs. 78; 86 vs. 94 mm Hg, P pressures......, but surprisingly normal arterial blood pressure during the nighttime, and the circadian variation in blood pressure and HR is diminished, probably because of an almost unaltered cardiac output during the 24 hours. These results may reflect a major defect in the ability of optimal regulation of blood pressure...

  7. Hourly rounding and patient falls: what factors boost success?

    Science.gov (United States)

    Goldsack, Jennifer; Bergey, Meredith; Mascioli, Susan; Cunningham, Janet

    2015-02-01

    Falls are a persistent problem in all healthcare settings, with rates in acute care hospitals ranging from 1.3 to 8.9 falls per 1,000 inpatient days, about 30% resulting in serious injury. A 30-day prospective pilot study was conducted on two units with pre- and postimplementation evaluation to determine the impact of patient-centered proactive hourly rounding on patient falls as part of a Lean Six Sigma process improvement project. Nurse leaders and a staff champion from Unit 1 were involved in the process from the start of the implementation period, while Unit 2 was introduced to the project for training shortly before the intervention began. On Unit 1, where staff and leadership were engaged in the project from the outset, the 1-year baseline mean fall rate was 3.9 falls/1,000 patient days. The pilot period fall rate of 1.3 falls/1,000 patient days was significantly lower than the baseline fall rate (P = 0.006). On Unit 2, where there was no run-in period, the 1-year baseline mean fall rate was 2.6 falls/1,000 patient days, which fell, but not significantly, to 2.5 falls/1,000 patient days during the pilot period (P = 0.799). Engaging an interdisciplinary team, including leadership and unit champions, to complete a Lean Six Sigma process improvement project and implement a patient-centered proactive hourly rounding program was associated with a significant reduction in the fall rate in Unit 1. Implementation of the same program in Unit 2 without engaging leadership or front-line staff in program design did not impact its fall rate. The active involvement of leadership and front-line staff in program design and as unit champions during the project run-in period was critical to significantly reducing inpatient fall rates and call bell use in an adult medical unit.

  8. A global surface drifter data set at hourly resolution

    Science.gov (United States)

    Elipot, Shane; Lumpkin, Rick; Perez, Renellys C.; Lilly, Jonathan M.; Early, Jeffrey J.; Sykulski, Adam M.

    2016-05-01

    The surface drifting buoys, or drifters, of the Global Drifter Program (GDP) are predominantly tracked by the Argos positioning system, providing drifter locations with O(100 m) errors at nonuniform temporal intervals, with an average interval of 1.2 h since January 2005. This data set is thus a rich and global source of information on high-frequency and small-scale oceanic processes, yet is still relatively understudied because of the challenges associated with its large size and sampling characteristics. A methodology is described to produce a new high-resolution global data set since 2005, consisting of drifter locations and velocities estimated at hourly intervals, along with their respective errors. Locations and velocities are obtained by modeling locally in time trajectories as a first-order polynomial with coefficients obtained by maximizing a likelihood function. This function is derived by modeling the Argos location errors with t location-scale probability distribution functions. The methodology is motivated by analyzing 82 drifters tracked contemporaneously by Argos and by the Global Positioning System, where the latter is assumed to provide true locations. A global spectral analysis of the velocity variance from the new data set reveals a sharply defined ridge of energy closely following the inertial frequency as a function of latitude, distinct energy peaks near diurnal and semidiurnal frequencies, as well as higher-frequency peaks located near tidal harmonics as well as near replicates of the inertial frequency. Compared to the spectra that can be obtained using the standard 6-hourly GDP product, the new data set contains up to 100% more spectral energy at some latitudes.

  9. Cross-National Differences in the Association between Parental Work Hours and Time with Children in Europe: A Multilevel Analysis

    Science.gov (United States)

    Roeters, Anne

    2013-01-01

    This study investigates cross-national differences in the association between parental work hours and parent-child interaction time and explains differences in this individual-level association on the basis of country characteristics. It extends prior research by testing the moderating effects of country characteristics through multilevel analyses…

  10. 29 CFR 778.318 - Productive and nonproductive hours of work.

    Science.gov (United States)

    2010-07-01

    ... STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION... Act; such nonproductive working hours must be counted and paid for. (b) Compensation payable for... hours standard is 40 hours is owed compensation at his regular rate for all of the first 40 hours and...

  11. Colleges Are Slashing Adjuncts' Hours to Skirt New Rules on Health-Insurance Eligibility

    Science.gov (United States)

    Dunn, Sydni

    2013-01-01

    Allison G. Armentrout, an adjunct instructor at Stark State College, does not get paid by the hour. She earns $4,600 to teach two English composition courses. But now she carefully tracks how many hours she works on an electronic time sheet. During a recent week, she spent three hours preparing for her lectures, close to six hours in the…

  12. Credit Hours with No Set Time: A Study of Credit Policies in Asynchronous Online Education

    Science.gov (United States)

    Prasuhn, Frederick Carl

    2014-01-01

    U.S. public university system policies were examined to learn how credit hours were determined for asynchronous online education. Findings indicated that (a) credit hour meaning and use are not consistent, (b) primary responsibility for credit hour decisions was at the local level, and (c) no policies exist to guide credit hour application for…

  13. Credit Hours with No Set Time: A Study of Credit Policies in Asynchronous Online Education

    Science.gov (United States)

    Prasuhn, Frederick Carl

    2014-01-01

    U.S. public university system policies were examined to learn how credit hours were determined for asynchronous online education. Findings indicated that (a) credit hour meaning and use are not consistent, (b) primary responsibility for credit hour decisions was at the local level, and (c) no policies exist to guide credit hour application for…

  14. Cephalometric effects of the use of 10-hour Force Theory for Class II treatment

    Directory of Open Access Journals (Sweden)

    Marise de Castro Cabrera

    2012-12-01

    Full Text Available OBJECTIVE: This study aimed to evaluate the cephalometric effects promoted by the orthodontic treatment of Class II malocclusion patients with the use of the 10-Hour Force Theory, that consists in the use of fixed appliances with 8 hours a day using a cervical headgear appliance and 16 hours a day using Class II elastics, 8 hours on the first mandibular molar and 8 hours in the second mandibular molar. METHODS: Sample comprised 31 patients with mean initial age of 14.90 years, final mean age of 17.25 years and mean treatment time of 2.35 years. The lateral cephalograms in pre-treatment and post-treatment stages were evaluated. Evaluation of cephalometric changes between initial and final treatment phases was performed by paired t test. RESULTS: The cases treated with the 10-Hour Force Theory presented a slight restriction of anterior displacement of the maxilla, increase in the effective length of the mandible, significant improvement of the maxillomandibular relationship, significant increase in anterior lower face height, distal tipping of the maxillary premolar crowns, extrusion and distal tipping of the roots of maxillary molars, significant proclination and protrusion of mandibular incisors, significant extrusion and mesialization of mandibular molars, besides a significant correction of the molar relationship, overjet and overbite. CONCLUSION: The use of the 10-Hour Force Theory in treatment of Class II malocclusion provided satisfactory results.OBJETIVO: esse estudo objetivou avaliar os efeitos cefalométricos promovidos pelo tratamento ortodôntico de pacientes com má oclusão de Classe II com o uso da Teoria de Força das 10 Horas, que consiste no uso de aparelho ortodôntico fixo, 8 horas diárias de uso de aparelho extrabucal cervical e 16 horas de uso de elásticos de Classe II, sendo 8 horas com apoio no primeiro molar inferior e 8 horas com apoio no segundo molar inferior. MÉTODOS: a amostra consistiu de 31 pacientes, com idade m

  15. The spatial return level of aggregated hourly extreme rainfall in Peninsular Malaysia

    Science.gov (United States)

    Shaffie, Mardhiyyah; Eli, Annazirin; Wan Zin, Wan Zawiah; Jemain, Abdul Aziz

    2015-07-01

    This paper is intended to ascertain the spatial pattern of extreme rainfall distribution in Peninsular Malaysia at several short time intervals, i.e., on hourly basis. Motivation of this research is due to historical records of extreme rainfall in Peninsular Malaysia, whereby many hydrological disasters at this region occur within a short time period. The hourly periods considered are 1, 2, 3, 6, 12, and 24 h. Many previous hydrological studies dealt with daily rainfall data; thus, this study enables comparison to be made on the estimated performances between daily and hourly rainfall data analyses so as to identify the impact of extreme rainfall at a shorter time scale. Return levels based on the time aggregate considered are also computed. Parameter estimation using L-moment method for four probability distributions, namely, the generalized extreme value (GEV), generalized logistic (GLO), generalized Pareto (GPA), and Pearson type III (PE3) distributions were conducted. Aided with the L-moment diagram test and mean square error (MSE) test, GLO was found to be the most appropriate distribution to represent the extreme rainfall data. At most time intervals (10, 50, and 100 years), the spatial patterns revealed that the rainfall distribution across the peninsula differ for 1- and 24-h extreme rainfalls. The outcomes of this study would provide additional information regarding patterns of extreme rainfall in Malaysia which may not be detected when considering only a higher time scale such as daily; thus, appropriate measures for shorter time scales of extreme rainfall can be planned. The implementation of such measures would be beneficial to the authorities to reduce the impact of any disastrous natural event.

  16. Temporary balloon occlusion of internal carotid artery : a simple and reliable clinical test.

    Directory of Open Access Journals (Sweden)

    Sudhakar K

    2000-04-01

    Full Text Available Balloon test occlusion of internal carotid artery has been frequently used in preoperative evaluation of patients with carotid aneurysms, fistulas and skull based neoplasms in whom arterial sacrifice is planned or considered as a possible part of therapy. We present our experience of the test in 28 patients. The test was positive in four and negative in twenty four patients. The results are compared with cross-compression angiography and the outcome following internal carotid artery sacrifice. There were no complications related to the test and the results accurately predicted the tolerance to occlusion of artery. We found the test safe, simple to perform and reliable to preoperatively detect patients at risk of ischaemic stroke following surgical ligation or endovascular occlusion of internal carotid artery.

  17. Multi-sensory stimulation in 24-hour dementia care

    NARCIS (Netherlands)

    Weert, J.C.M. van

    2004-01-01

    This thesis starts with a review of relevant literature with regard to the effects of psychosocial interventions, including snoezelen, on apathetic, depressed and aggressive behaviour of demented persons. Then, a study with a quasi-experimental pre-test and post-test design is described, comparing s

  18. Multi-sensory stimulation in 24-hour dementia care

    NARCIS (Netherlands)

    Weert, J.C.M. van

    2004-01-01

    This thesis starts with a review of relevant literature with regard to the effects of psychosocial interventions, including snoezelen, on apathetic, depressed and aggressive behaviour of demented persons. Then, a study with a quasi-experimental pre-test and post-test design is described, comparing s

  19. Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.

    Science.gov (United States)

    Ostrosky-Zeichner, Luis; Rex, John H; Pfaller, Michael A; Diekema, Daniel J; Alexander, Barbara D; Andes, David; Brown, Steven D; Chaturvedi, Vishnu; Ghannoum, Mahmoud A; Knapp, Cindy C; Sheehan, Daniel J; Walsh, Thomas J

    2008-11-01

    We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

  20. Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method▿

    Science.gov (United States)

    Ostrosky-Zeichner, Luis; Rex, John H.; Pfaller, Michael A.; Diekema, Daniel J.; Alexander, Barbara D.; Andes, David; Brown, Steven D.; Chaturvedi, Vishnu; Ghannoum, Mahmoud A.; Knapp, Cindy C.; Sheehan, Daniel J.; Walsh, Thomas J.

    2008-01-01

    We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata. PMID:18809944

  1. Hourly Wind Speed Interval Prediction in Arid Regions

    Science.gov (United States)

    Chaouch, M.; Ouarda, T.

    2013-12-01

    context, probabilistic forecasts might be more relevant than point forecasts for the planner to build scenarios In this paper, we are interested in estimating predictive intervals of the hourly wind speed measures in few cities in United Arab emirates (UAE). More precisely, given a wind speed time series, our target is to forecast the wind speed at any specific hour during the day and provide in addition an interval with the coverage probability 0forecast wind speed.

  2. A Global Stem Cell Niche – Need of the Hour

    Directory of Open Access Journals (Sweden)

    Editorial

    2014-11-01

    Full Text Available A Global Stem Cell Niche – Need of the Hour The time, this issue is online, most of us would be aware of the world’s first induced pluripotent stem (iPS cell based clinical trial for age-related macular degeneration which is underway in Japan. The first patient in the trial has been transplanted with the cell sheets of retinal pigment epithelium derived from the patient's own iPS cells in September 2014 [1] and is under follow-up. As we are overwhelmed with this scientific feat, an analysis of the trends of stem cell based clinical trials globally [2] makes us realize that there is a wide variation in the clinical trials between the nations, with differences being observed in diseases that are given priority, cell sources that are being chosen, principles of ethics, regulatory frameworks etc,. A realization dawns that the scientific communities in each group or country have their own niche of cell based research leading to the above mentioned variations. While in Japan, a hi-tech iPS trial has started, Mazini et al from Morocco, describe the hurdles in creating a public cord blood bank in their country with a background of the regulatory guidelines existing there while Lee et al's work from the United States of America (USA focuses on microencapsulation of adipose derived stem cells. While each of the above subject are equally important, a global consortium is the need of the hour, where interactions among all the stake holders of cell based therapies can be established for enabling exchange of information, technology, solutions and products, thereby avoiding repetition of the same work, while gaining the insight of different viewpoints into solving an issue which could be of significance either to a local community or the entire global society. References: Reardon S, Cyranoski D. Japan stem-cell trial stirs envy. Nature. 2014 ;513(7518:287-8. Li MD, Atkins H, Bubela T. The global landscape of stem cell clinical trials. Regen Med. 2014;9(1:27-39.

  3. Thrombectomy within 8 hours after symptom onset in ischemic stroke.

    Science.gov (United States)

    Jovin, Tudor G; Chamorro, Angel; Cobo, Erik; de Miquel, María A; Molina, Carlos A; Rovira, Alex; San Román, Luis; Serena, Joaquín; Abilleira, Sonia; Ribó, Marc; Millán, Mònica; Urra, Xabier; Cardona, Pere; López-Cancio, Elena; Tomasello, Alejandro; Castaño, Carlos; Blasco, Jordi; Aja, Lucía; Dorado, Laura; Quesada, Helena; Rubiera, Marta; Hernandez-Pérez, María; Goyal, Mayank; Demchuk, Andrew M; von Kummer, Rüdiger; Gallofré, Miquel; Dávalos, Antoni

    2015-06-11

    We aimed to assess the safety and efficacy of thrombectomy for the treatment of stroke in a trial embedded within a population-based stroke reperfusion registry. During a 2-year period at four centers in Catalonia, Spain, we randomly assigned 206 patients who could be treated within 8 hours after the onset of symptoms of acute ischemic stroke to receive either medical therapy (including intravenous alteplase when eligible) and endovascular therapy with the Solitaire stent retriever (thrombectomy group) or medical therapy alone (control group). All patients had confirmed proximal anterior circulation occlusion and the absence of a large infarct on neuroimaging. In all study patients, the use of alteplase either did not achieve revascularization or was contraindicated. The primary outcome was the severity of global disability at 90 days, as measured on the modified Rankin scale (ranging from 0 [no symptoms] to 6 [death]). Although the maximum planned sample size was 690, enrollment was halted early because of loss of equipoise after positive results for thrombectomy were reported from other similar trials. Thrombectomy reduced the severity of disability over the range of the modified Rankin scale (adjusted odds ratio for improvement of 1 point, 1.7; 95% confidence interval [CI], 1.05 to 2.8) and led to higher rates of functional independence (a score of 0 to 2) at 90 days (43.7% vs. 28.2%; adjusted odds ratio, 2.1; 95% CI, 1.1 to 4.0). At 90 days, the rates of symptomatic intracranial hemorrhage were 1.9% in both the thrombectomy group and the control group (P=1.00), and rates of death were 18.4% and 15.5%, respectively (P=0.60). Registry data indicated that only eight patients who met the eligibility criteria were treated outside the trial at participating hospitals. Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disability and increased the

  4. Nutritional behavior of cyclists during a 24-hour team relay race: a field study report

    Directory of Open Access Journals (Sweden)

    Bescós Raúl

    2012-02-01

    Full Text Available Abstract Background Information about behavior of energy intake in ultra-endurance cyclists during a 24-hour team relay race is scarce. The nutritional strategy during such an event is an important factor which athletes should plan carefully before the race. The purpose of this study was to examine and compare the nutritional intake of ultra-endurance cyclists during a 24-hour team relay race with the current nutritional guidelines for endurance events. Additionally, we analyzed the relationship among the nutritional and performance variables. Methods Using a observational design, nutritional intake of eight males (mean ± SD: 36.7 ± 4.7 years; 71.6 ± 4.9 kg; 174.6 ± 7.3 cm; BMI 23.5 ± 0.5 kg/m2 participating in a 24-hour team relay cycling race was assessed. All food and fluid intake by athletes were weighed and recorded. Additionally, distance and speed performed by each rider were also recorded. Furthermore, before to the race, all subjects carried out an incremental exercise test to determine two heart rate-VO2 regression equations which were used to estimate the energy expenditure. Results The mean ingestion of macronutrients during the event was 943 ± 245 g (13.1 ± 4.0 g/kg of carbohydrates, 174 ± 146 g (2.4 ± 1.9 g/kg of proteins and 107 ± 56 g (1.5 ± 0.7 g/kg of lipids, respectively. This amount of nutrients reported an average nutrient intake of 22.8 ± 8.9 MJ which were significantly lower compared with energy expenditure 42.9 ± 6.8 MJ (P = 0.012. Average fluid consumption corresponded to 10497 ± 2654 mL. Mean caffeine ingestion was 142 ± 76 mg. Additionally, there was no relationship between the main nutritional variables (i.e. energy intake, carbohydrates, proteins, fluids and caffeine ingestion and the main performance variables (i.e. distance and speed. Conclusions A 24-hour hours cycling competition in a team relay format elicited high energy demands which were not compensated by energy intake of the athletes despite

  5. The effect of duty hour regulation on resident surgical case volume in otolaryngology.

    Science.gov (United States)

    Curtis, Stuart H; Miller, Robert H; Weng, Cindy; Gurgel, Richard K

    2014-10-01

    Evaluate the effect of duty hour regulation on graduating otolaryngology resident surgical case volume and analyze trends in surgical case volume for Accreditation Council for Graduate Medical Education (ACGME) key indicator cases from 1996 to 2011. Time-trend analysis of surgical case volume. Nationwide sample of otolaryngology residency programs. Operative logs from the American Board of Otolaryngology and ACGME for otolaryngology residents graduating in the years 1996 to 2011. Key indicator volumes and grouped domain volumes before and after resident duty hour regulations (2003) were calculated and compared. Independent t test was performed to evaluate overall difference in operative volume. Wilcoxon rank sum test evaluated differences between procedures per time period. Linear regression evaluated trend. The average total number of key indicator cases per graduating resident was 440.8 in 1996-2003 compared to 500.4 cases in 2004-2011, and overall average per number of key indicators was 31.5 and 36.2, respectively (P = .067). Four key indicator cases showed statistically significant (P otolaryngology residents. The overall trend in operative volume is increasing for several specific key indicators. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

  6. International 24-Hour LEO Space Debris Measurement Campaign 2015

    Science.gov (United States)

    Hamilton, Joseph; Letsch, Klemens; Blackwell, Christopher; McSheehy, Richard; Quanette, Juarez

    2017-01-01

    The Inter-Agency Space Debris Coordination Committee (IADC) provides the organizational framework for sponsoring periodic international measurement campaigns of the space debris environment. The IADC has conducted two types of campaigns: high altitude campaigns designed to measure the debris environment at near-geostationary altitudes using mostly optical telescopes, and low altitude campaigns using primarily radars. One of the goals of the low altitude campaigns is to collect data for 24 contiguous hours. This way, all orbit planes can be sampled. Multiple sensors are used, each with its own strengths and weaknesses, to provide a more complete understanding of the environment. Comparing results between sensors also provides a better understanding of the potential biases resulting from any one sensor. Conducting the campaigns at roughly regular intervals over a long period also allows researchers to examine trends and growth of the environment over time. For this reason, low altitude campaigns are anticipated at two-year intervals. This is the eighth IADC low altitude campaign conducted. The first campaign was conducted in 1996 and two campaigns were conducted in 1999. The 2002 campaign was delayed until January 2003 because of scheduling conflicts, and the fifth, sixth, and seventh campaigns were conducted in 2004, 2008, and 2013 respectively. The eighth campaign was conducted on 8 December 2015.

  7. Managing sleep and wakefulness in a 24-hour world.

    Science.gov (United States)

    Coveney, Catherine M

    2014-01-01

    This article contributes to literature on the sociology of sleep by exploring the sleeping practices and subjective sleep experiences of two social groups: shift workers and students. It draws on data, collected in the UK from 25 semi-structured interviews, to discuss the complex ways in which working patterns and social activities impact upon experiences and expectations of sleep in our wired awake world. The data show that, typically, sleep is valued and considered to be important for health, general wellbeing, appearance and physical and cognitive functioning. However, sleep time is often cut back on in favour of work demands and social activities. While shift workers described their efforts to fit in an adequate amount of sleep per 24-hour period, for students, the adoption of a flexible sleep routine was thought to be favourable for maintaining a work-social life balance. Collectively, respondents reported using a wide range of strategies, techniques, technologies and practices to encourage, overcome or delay sleep(iness) and boost, promote or enhance wakefulness/alertness at socially desirable times. The analysis demonstrates how social context impacts not only on how we come to think about sleep and understand it, but also how we manage or self-regulate our sleeping patterns.

  8. Improvements in PIXE analysis of hourly particulate matter samples

    Energy Technology Data Exchange (ETDEWEB)

    Calzolai, G., E-mail: calzolai@fi.infn.it [Department of Physics and Astronomy, University of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); National Institute of Nuclear Physics (INFN), Division of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Lucarelli, F. [Department of Physics and Astronomy, University of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); National Institute of Nuclear Physics (INFN), Division of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Chiari, M.; Nava, S. [National Institute of Nuclear Physics (INFN), Division of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Giannoni, M. [National Institute of Nuclear Physics (INFN), Division of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (Italy); Carraresi, L. [Department of Physics and Astronomy, University of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); National Institute of Nuclear Physics (INFN), Division of Florence, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Prati, P. [Department of Physics, University of Genoa and INFN Division of Genoa, Via Dodecaneso 33, 16146 Genoa (Italy); Vecchi, R. [Department of Physics, Università degli Studi di Milano and INFN Division of Milan, Via Celoria 16, 20133 Milan (Italy)

    2015-11-15

    Most air quality studies on particulate matter (PM) are based on 24-h averaged data; however, many PM emissions as well as their atmospheric dilution processes change within a few hours. Samplings of PM with 1-h resolution can be performed by the streaker sampler (PIXE International Corporation), which is designed to separate the fine (aerodynamic diameter less than 2.5 μm) and the coarse (aerodynamic diameter between 2.5 and 10 μm) fractions of PM. These samples are efficiently analyzed by Particle Induced X-ray Emission (PIXE) at the LABEC laboratory of INFN in Florence (Italy), equipped with a 3 MV Tandetron accelerator, thanks to an optimized external-beam set-up, a convenient choice of the beam energy and suitable collecting substrates. A detailed description of the adopted set-up and results from a methodological study on the detection limits for the selection of the optimal beam energy are shown; the outcomes of the research on alternative collecting substrates, which produce a lower background during the measurements, and with lower contaminations, are also discussed.

  9. Improvements in PIXE analysis of hourly particulate matter samples

    Science.gov (United States)

    Calzolai, G.; Lucarelli, F.; Chiari, M.; Nava, S.; Giannoni, M.; Carraresi, L.; Prati, P.; Vecchi, R.

    2015-11-01

    Most air quality studies on particulate matter (PM) are based on 24-h averaged data; however, many PM emissions as well as their atmospheric dilution processes change within a few hours. Samplings of PM with 1-h resolution can be performed by the streaker sampler (PIXE International Corporation), which is designed to separate the fine (aerodynamic diameter less than 2.5 μm) and the coarse (aerodynamic diameter between 2.5 and 10 μm) fractions of PM. These samples are efficiently analyzed by Particle Induced X-ray Emission (PIXE) at the LABEC laboratory of INFN in Florence (Italy), equipped with a 3 MV Tandetron accelerator, thanks to an optimized external-beam set-up, a convenient choice of the beam energy and suitable collecting substrates. A detailed description of the adopted set-up and results from a methodological study on the detection limits for the selection of the optimal beam energy are shown; the outcomes of the research on alternative collecting substrates, which produce a lower background during the measurements, and with lower contaminations, are also discussed.

  10. Infectious encephalitis: Management without etiological diagnosis 48hours after onset.

    Science.gov (United States)

    Fillatre, P; Crabol, Y; Morand, P; Piroth, L; Honnorat, J; Stahl, J P; Lecuit, M

    2017-05-01

    The etiological diagnosis of infectious encephalitis is often not established 48hours after onset. We aimed to review existing literature data before providing management guidelines. We performed a literature search on PubMed using filters such as "since 01/01/2000", "human", "adults", "English or French", and "clinical trial/review/guidelines". We also used the Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis". With Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis", we retrieved 223 and 258 articles, respectively. With search terms "encephalitis and corticosteroid", we identified 38 articles, and with "encephalitis and doxycycline" without the above-mentioned filters we identified 85 articles. A total of 210 articles were included in the analysis. Etiological investigations must focus on recent travels, animal exposures, age, immunodeficiency, neurological damage characteristics, and potential extra-neurological signs. The interest of a diagnosis of encephalitis for which there is no specific treatment is also to discontinue any empirical treatments initially prescribed. Physicians must consider and search for autoimmune encephalitis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. Approach to decreasing emergency department ambulance diversion hours.

    Science.gov (United States)

    Vilke, Gary M; Brown, Lana; Skogland, Patty; Simmons, Charles; Guss, David A

    2004-02-01

    Analysis between two local Emergency Departments (EDs) suggested an oscillatory phenomenon for ambulance diversion: When one hospital went on diversion it led to a disproportionate flow of ambulance traffic to a neighboring facility that subsequently was forced to go on divert. We hypothesized if one hospital could avoid diversion status, the need for diversion could be averted in the neighboring facility. ED A secured additional resources and made a commitment to no diversion for 1 week. No changes in operations occurred in hospital B. We found no differences in ambulance runs or ED census at either facility comparing the week before, during, and after the trial. There was a dramatic decline in diversion hours from 19.7 to 1.4 and 27.7 to 0 at hospitals A and B, respectively, during the trial period (p < 0.05) compared to the weeks before and after. We conclude that reciprocating effects can be decreased with one institution's commitment to avoid diversion, thus decreasing the need for diversion at a neighboring facility.

  12. Latent error detection: A golden two hours for detection.

    Science.gov (United States)

    Saward, Justin R E; Stanton, Neville A

    2017-03-01

    Undetected error in safety critical contexts generates a latent condition that can contribute to a future safety failure. The detection of latent errors post-task completion is observed in naval air engineers using a diary to record work-related latent error detection (LED) events. A systems view is combined with multi-process theories to explore sociotechnical factors associated with LED. Perception of cues in different environments facilitates successful LED, for which the deliberate review of past tasks within two hours of the error occurring and whilst remaining in the same or similar sociotechnical environment to that which the error occurred appears most effective. Identified ergonomic interventions offer potential mitigation for latent errors; particularly in simple everyday habitual tasks. It is thought safety critical organisations should look to engineer further resilience through the application of LED techniques that engage with system cues across the entire sociotechnical environment, rather than relying on consistent human performance. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  13. Analyzing a 35-Year Hourly Data Record: Why So Difficult?

    Science.gov (United States)

    Lynnes, Chris

    2014-01-01

    At the Goddard Distributed Active Archive Center, we have recently added a 35-Year record of output data from the North American Land Assimilation System (NLDAS) to the Giovanni web-based analysis and visualization tool. Giovanni (Geospatial Interactive Online Visualization ANd aNalysis Infrastructure) offers a variety of data summarization and visualization to users that operate at the data center, obviating the need for users to download and read the data themselves for exploratory data analysis. However, the NLDAS data has proven surprisingly resistant to application of the summarization algorithms. Algorithms that were perfectly happy analyzing 15 years of daily satellite data encountered limitations both at the algorithm and system level for 35 years of hourly data. Failures arose, sometimes unexpectedly, from command line overflows, memory overflows, internal buffer overflows, and time-outs, among others. These serve as an early warning sign for the problems likely to be encountered by the general user community as they try to scale up to Big Data analytics. Indeed, it is likely that more users will seek to perform remote web-based analysis precisely to avoid the issues, or the need to reprogram around them. We will discuss approaches to mitigating the limitations and the implications for data systems serving the user communities that try to scale up their current techniques to analyze Big Data.

  14. Full reconstruction of a 14-qubit state within four hours

    Science.gov (United States)

    Hou, Zhibo; Zhong, Han-Sen; Tian, Ye; Dong, Daoyi; Qi, Bo; Li, Li; Wang, Yuanlong; Nori, Franco; Xiang, Guo-Yong; Li, Chuan-Feng; Guo, Guang-Can

    2016-08-01

    Full quantum state tomography (FQST) plays a unique role in the estimation of the state of a quantum system without a priori knowledge or assumptions. Unfortunately, since FQST requires informationally (over)complete measurements, both the number of measurement bases and the computational complexity of data processing suffer an exponential growth with the size of the quantum system. A 14-qubit entangled state has already been experimentally prepared in an ion trap, and the data processing capability for FQST of a 14-qubit state seems to be far away from practical applications. In this paper, the computational capability of FQST is pushed forward to reconstruct a 14-qubit state with a run time of only 3.35 hours using the linear regression estimation (LRE) algorithm, even when informationally overcomplete Pauli measurements are employed. The computational complexity of the LRE algorithm is first reduced from ∼1019 to ∼1015 for a 14-qubit state, by dropping all the zero elements, and its computational efficiency is further sped up by fully exploiting the parallelism of the LRE algorithm with parallel Graphic Processing Unit (GPU) programming. Our result demonstrates the effectiveness of using parallel computation to speed up the postprocessing for FQST, and can play an important role in quantum information technologies with large quantum systems.

  15. Hourly simulation of a Ground-Coupled Heat Pump system

    Science.gov (United States)

    Naldi, C.; Zanchini, E.

    2017-01-01

    In this paper, we present a MATLAB code for the hourly simulation of a whole Ground-Coupled Heat Pump (GCHP) system, based on the g-functions previously obtained by Zanchini and Lazzari. The code applies both to on-off heat pumps and to inverter-driven ones. It is employed to analyse the effects of the inverter and of the total length of the Borehole Heat Exchanger (BHE) field on the mean seasonal COP (SCOP) and on the mean seasonal EER (SEER) of a GCHP system designed for a residential house with 6 apartments in Bologna, North-Center Italy, with dominant heating loads. A BHE field with 3 in line boreholes is considered, with length of each BHE either 75 m or 105 m. The results show that the increase of the BHE length yields a SCOP enhancement of about 7%, while the SEER remains nearly unchanged. The replacement of the on-off heat pump by an inverter-driven one yields a SCOP enhancement of about 30% and a SEER enhancement of about 50%. The results demonstrate the importance of employing inverter-driven heat pumps for GCHP systems.

  16. Glucose turnover in 48-hour-fasted running rats

    Energy Technology Data Exchange (ETDEWEB)

    Sonne, B.; Mikines, K.J.; Galbo, H.

    1987-03-01

    In fed rats, hyperglycemia develops during exercise. This contrasts with the view based on studies of fasted human and dog that euglycemia is maintained in exercise and glucose production (R/sub a/) controlled by feedback mechanisms. Forty-eight-hour-fasted rats (F) were compared to fed rats (C) and overnight food-restricted (FR) rats. (3-/sup 3/H)- and (U-/sup 14/C)glucose were infused and blood and tissue sampled. During running (21 m/min, 0% grade) R/sub a/ increased most in C and least in F and only in F did R/sub a/ not significantly exceed glucose disappearance. Plasma glucose increased more in C (3.3 mmol/1) than in FR (1.6 mmol/l) and only modestly (0.6 mmol/l) and transiently in F. Resting liver glycogen and exercise glycogenolysis were highest in C and similar in FR and F. Resting muscle glycogen and exercise glycogenolysis were highest in C and lowest in F. During running, lactate production and gluconeogenesis were higher in FR than in F. At least in rats, responses of production and plasma concentration of glucose to exercise depend on size of liver and muscle glycogen stores; glucose production matches increase in clearance better in fasted than in fed states. Probably glucose production is stimulated by feedforward mechanisms and feedback mechanisms are added if plasma glucose decreases.

  17. Across the continuum of satisfaction with work-family balance: Work hours, flexibility-fit, and work-family culture.

    Science.gov (United States)

    McNamara, Tay K; Pitt-Catsouphes, Marcie; Matz-Costa, Christina; Brown, Melissa; Valcour, Monique

    2013-03-01

    This study investigated the association between hours worked per week and satisfaction with work-family balance, using data from a 2007-2008 survey of employees nested within organizations. We tested hypotheses informed by the resource drain and resources-and-demands perspectives using quantile regression. We found that the negative association between hours worked per week and satisfaction with work-family balance was significantly stronger at the 25th percentile, as compared to at the 75th percentile, of satisfaction with work-family balance. Further, there was some evidence that perceived flexibility-fit (i.e., the fit between worker needs and flexible work options available) and supportive work-family culture attenuated the relationship between hours worked and satisfaction with work-family balance. The results suggest that analyses focusing on the average relationship between long work hours (such as those using ordinary least squares regression) and satisfaction with work-family balance may underestimate the importance of long work hours for workers with lower satisfaction levels.

  18. A gridded hourly rainfall dataset for the UK applied to a national physically-based modelling system

    Science.gov (United States)

    Lewis, Elizabeth; Blenkinsop, Stephen; Quinn, Niall; Freer, Jim; Coxon, Gemma; Woods, Ross; Bates, Paul; Fowler, Hayley

    2016-04-01

    An hourly gridded rainfall product has great potential for use in many hydrological applications that require high temporal resolution meteorological data. One important example of this is flood risk management, with flooding in the UK highly dependent on sub-daily rainfall intensities amongst other factors. Knowledge of sub-daily rainfall intensities is therefore critical to designing hydraulic structures or flood defences to appropriate levels of service. Sub-daily rainfall rates are also essential inputs for flood forecasting, allowing for estimates of peak flows and stage for flood warning and response. In addition, an hourly gridded rainfall dataset has significant potential for practical applications such as better representation of extremes and pluvial flash flooding, validation of high resolution climate models and improving the representation of sub-daily rainfall in weather generators. A new 1km gridded hourly rainfall dataset for the UK has been created by disaggregating the daily Gridded Estimates of Areal Rainfall (CEH-GEAR) dataset using comprehensively quality-controlled hourly rain gauge data from over 1300 observation stations across the country. Quality control measures include identification of frequent tips, daily accumulations and dry spells, comparison of daily totals against the CEH-GEAR daily dataset, and nearest neighbour checks. The quality control procedure was validated against historic extreme rainfall events and the UKCP09 5km daily rainfall dataset. General use of the dataset has been demonstrated by testing the sensitivity of a physically-based hydrological modelling system for Great Britain to the distribution and rates of rainfall and potential evapotranspiration. Of the sensitivity tests undertaken, the largest improvements in model performance were seen when an hourly gridded rainfall dataset was combined with potential evapotranspiration disaggregated to hourly intervals, with 61% of catchments showing an increase in NSE between

  19. High-resolution grids of hourly meteorological variables for Germany

    Science.gov (United States)

    Krähenmann, S.; Walter, A.; Brienen, S.; Imbery, F.; Matzarakis, A.

    2016-12-01

    We present a 1-km2 gridded German dataset of hourly surface climate variables covering the period 1995 to 2012. The dataset comprises 12 variables including temperature, dew point, cloud cover, wind speed and direction, global and direct shortwave radiation, down- and up-welling longwave radiation, sea level pressure, relative humidity and vapour pressure. This dataset was constructed statistically from station data, satellite observations and model data. It is outstanding in terms of spatial and temporal resolution and in the number of climate variables. For each variable, we employed the most suitable gridding method and combined the best of several information sources, including station records, satellite-derived data and data from a regional climate model. A module to estimate urban heat island intensity was integrated for air and dew point temperature. Owing to the low density of available synop stations, the gridded dataset does not capture all variations that may occur at a resolution of 1 km2. This applies to areas of complex terrain (all the variables), and in particular to wind speed and the radiation parameters. To achieve maximum precision, we used all observational information when it was available. This, however, leads to inhomogeneities in station network density and affects the long-term consistency of the dataset. A first climate analysis for Germany was conducted. The Rhine River Valley, for example, exhibited more than 100 summer days in 2003, whereas in 1996, the number was low everywhere in Germany. The dataset is useful for applications in various climate-related studies, hazard management and for solar or wind energy applications and it is available via doi: 10.5676/DWD_CDC/TRY_Basis_v001.

  20. Ergogenic demands of a 24 hour cycling event.

    Science.gov (United States)

    White, J A; Ward, C; Nelson, H

    1984-09-01

    The maximal aerobic performance (VO2 max) and energy costs of cycling at various power outputs and equivalent road speeds of a highly trained endurance cyclist (age 23.4 yrs, height 1.95 m, weight 73.1 kg), were measured in the laboratory on an eddy-current cycle ergometer, and the physiological responses related to determinations made during a 24 h cycling time trial event, using continuous ECG recording from which estimates of ergogenic demands were obtained. The cyclist covered a distance of 694 km during the event at an average speed of 28.9 km.h-1 which corresponded to an equivalent oxygen cost of 38.5 ml.kg-1 min-1 and represented approximately 55% of his VO2 max. During the event, the cyclist expended an estimated 82,680 kJ of energy, of which approximately 44,278 kJ (54%) were supplied by repeated feedings of liquids, solids and semi-solids and some 38,402 kJ (46%) came from the stored energy reserves which resulted in a 1.19 kg loss of body weight during the event. The energy demands of the activity were more than three times greater than the highest recorded values of severe industrial work, and similar to the hourly rates of expenditure of shorter duration competitive events, but above the highest values reported over other extreme endurance events over the same period of time. The results thus represent near maximal levels of sustainable ergogenic effort by man over a complete 24 h cycle.

  1. Exploring the experiences patients who undergo 24hour Video- electroencephalography

    Directory of Open Access Journals (Sweden)

    Antigoni Fountouki

    2012-07-01

    Full Text Available Epilepsy is a frequent neurological disorder well-known by ancient times. The most accurate and valid diagnostic tool for epilepsy, is electroencephalography which provides details on the brain's function by recording brain cells' waves. Aim of the study was the exploration of the patients' total experience at a psychological and emotional level during a 24hour EEG. Materials and Methods: The sample included 40 subjects aged 18-40 years with a history or suspicion of epileptic symptoms. Due to the study's explorative/explicative nature, a qualitative research design was used. Data collection was performed through semi-structured interviews, direct observations and field notes. Following patients' permission, the interviews were recorded and the verbatim data was analyzed via thematic content analysis. Results: The verbatim text was the raw material where key words or phrases with autonomous meaning, relevant to the study's aims where subsequently organized in 4 major themes and 20 sub-categories, namely: Emotional-Psychological state (Positive: Joy, Optimism, Positive Thinking, Self-Confidence. Negative: Sadness, Anxiety, Fear, Panic, Pessimism. Behavior of patients (Calmness, Comfort, Nervousness, Aggravation. Options for patient involvement (TV, Reading, Music, Sleep, Lack of internet. Interpersonal relationships (family, friendly. Conclusions: During achieving the study's aims, many methodological and practical obstacles have been encountered as it proved to be particularly challenging to encompass patients' emotions and accurately cite their experiences during the EEG. However, results that have been revealed are adequate in formulating a holistic picture about the psychological state and the emotions that patients experience during the procedure.

  2. Assessment of a stochastic downscaling methodology in generating an ensemble of hourly future climate time series

    Science.gov (United States)

    Fatichi, S.; Ivanov, V. Y.; Caporali, E.

    2013-04-01

    This study extends a stochastic downscaling methodology to generation of an ensemble of hourly time series of meteorological variables that express possible future climate conditions at a point-scale. The stochastic downscaling uses general circulation model (GCM) realizations and an hourly weather generator, the Advanced WEather GENerator (AWE-GEN). Marginal distributions of factors of change are computed for several climate statistics using a Bayesian methodology that can weight GCM realizations based on the model relative performance with respect to a historical climate and a degree of disagreement in projecting future conditions. A Monte Carlo technique is used to sample the factors of change from their respective marginal distributions. As a comparison with traditional approaches, factors of change are also estimated by averaging GCM realizations. With either approach, the derived factors of change are applied to the climate statistics inferred from historical observations to re-evaluate parameters of the weather generator. The re-parameterized generator yields hourly time series of meteorological variables that can be considered to be representative of future climate conditions. In this study, the time series are generated in an ensemble mode to fully reflect the uncertainty of GCM projections, climate stochasticity, as well as uncertainties of the downscaling procedure. Applications of the methodology in reproducing future climate conditions for the periods of 2000-2009, 2046-2065 and 2081-2100, using the period of 1962-1992 as the historical baseline are discussed for the location of Firenze (Italy). The inferences of the methodology for the period of 2000-2009 are tested against observations to assess reliability of the stochastic downscaling procedure in reproducing statistics of meteorological variables at different time scales.

  3. Cost-effectiveness of thrombolysis within 4.5 hours of acute ischemic stroke in China.

    Directory of Open Access Journals (Sweden)

    Yuesong Pan

    Full Text Available BACKGROUND: Previous economic studies conducted in developed countries showed intravenous tissue-type plasminogen activator (tPA is cost-effective for acute ischemic stroke. The present study aimed to determine the cost-effectiveness of tPA treatment in China, the largest developing country. METHODS: A combination of decision tree and Markov model was developed to determine the cost-effectiveness of tPA treatment versus non-tPA treatment within 4.5 hours after stroke onset. Outcomes and costs data were derived from the database of Thrombolysis Implementation and Monitor of acute ischemic Stroke in China (TIMS-China study. Efficacy data were derived from a pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Costs and quality-adjusted life-years (QALYs were compared in both short term (2 years and long term (30 years. One-way and probabilistic sensitivity analyses were performed to test the robustness of the results. RESULTS: Comparing to non-tPA treatment, tPA treatment within 4.5 hours led to a short-term gain of 0.101 QALYs at an additional cost of CNY 9,520 (US$ 1,460, yielding an incremental cost-effectiveness ratio (ICER of CNY 94,300 (US$ 14,500 per QALY gained in 2 years; and to a long-term gain of 0.422 QALYs at an additional cost of CNY 6,530 (US$ 1,000, yielding an ICER of CNY 15,500 (US$ 2,380 per QALY gained in 30 years. Probabilistic sensitivity analysis showed that tPA treatment is cost-effective in 98.7% of the simulations at a willingness-to-pay threshold of CNY 105,000 (US$ 16,200 per QALY. CONCLUSIONS: Intravenous tPA treatment within 4.5 hours is highly cost-effective for acute ischemic strokes in China.

  4. Psychomotor performance of Polish Air Force cadets after 36 hours of survival training.

    Science.gov (United States)

    Tomczak, Andrzej; Dąbrowski, Jan; Mikulski, Tomasz

    2017-09-21

    The preparation of Polish Air Force cadets for survival in isolation is a necessary element of their training, to demonstrate just how difficult can be the conditions they could encounter in a combat situation. Objective. The aim of the research was to assess the effect of long-term survival training on selected coordination motor skills in Air Force cadets. Fifteen air force cadets aged 19.6±0.3 years exercised for 36 hours during survival training without the possibility to sleep. They were examined 4 times: Day 1 - before effort (training), Day 2 - after 24 hours training, Day 3 - directly after 36 hours training, Day 4 - next day, after an all night rest. They were examined for shooting and reaction time, the ability to maintain body balance, running motor adjustment, handgrip force differentiation, and on Days 1 and 3, exercise capacity was evaluated with a 1 mile walking test. The survival training resulted in significant decreases in maximum handgrip strength, corrected 50% max handgrip, maintenance of body balance and heart rate. No changes occurred in reaction time, running motor adjustment and shooting performance. Overnight rest did not result in recovery of any of the examined factors to the values observed on Day 1. Survival training combined with sleep deprivation mostly affected peripheral factors depending on strong action from both muscles and nervous system, whereas complex tasks involving short-term central alertness and moderate exertion were maintained. In order to improve performance, more endurance strength training, if possible combined with sleep deprivation, should be introduced in military training.

  5. A space-time hybrid hourly rainfall model for derived flood frequency analysis

    Directory of Open Access Journals (Sweden)

    U. Haberlandt

    2008-12-01

    Full Text Available For derived flood frequency analysis based on hydrological modelling long continuous precipitation time series with high temporal resolution are needed. Often, the observation network with recording rainfall gauges is poor, especially regarding the limited length of the available rainfall time series. Stochastic precipitation synthesis is a good alternative either to extend or to regionalise rainfall series to provide adequate input for long-term rainfall-runoff modelling with subsequent estimation of design floods. Here, a new two step procedure for stochastic synthesis of continuous hourly space-time rainfall is proposed and tested for the extension of short observed precipitation time series.

    First, a single-site alternating renewal model is presented to simulate independent hourly precipitation time series for several locations. The alternating renewal model describes wet spell durations, dry spell durations and wet spell intensities using univariate frequency distributions separately for two seasons. The dependence between wet spell intensity and duration is accounted for by 2-copulas. For disaggregation of the wet spells into hourly intensities a predefined profile is used. In the second step a multi-site resampling procedure is applied on the synthetic point rainfall event series to reproduce the spatial dependence structure of rainfall. Resampling is carried out successively on all synthetic event series using simulated annealing with an objective function considering three bivariate spatial rainfall characteristics. In a case study synthetic precipitation is generated for some locations with short observation records in two mesoscale catchments of the Bode river basin located in northern Germany. The synthetic rainfall data are then applied for derived flood frequency analysis using the hydrological model HEC-HMS. The results show good performance in reproducing average and extreme rainfall characteristics as well as in

  6. Stochastic modeling of hourly rainfall times series in Campania (Italy)

    Science.gov (United States)

    Giorgio, M.; Greco, R.

    2009-04-01

    Occurrence of flowslides and floods in small catchments is uneasy to predict, since it is affected by a number of variables, such as mechanical and hydraulic soil properties, slope morphology, vegetation coverage, rainfall spatial and temporal variability. Consequently, landslide risk assessment procedures and early warning systems still rely on simple empirical models based on correlation between recorded rainfall data and observed landslides and/or river discharges. Effectiveness of such systems could be improved by reliable quantitative rainfall prediction, which can allow gaining larger lead-times. Analysis of on-site recorded rainfall height time series represents the most effective approach for a reliable prediction of local temporal evolution of rainfall. Hydrological time series analysis is a widely studied field in hydrology, often carried out by means of autoregressive models, such as AR, ARMA, ARX, ARMAX (e.g. Salas [1992]). Such models gave the best results when applied to the analysis of autocorrelated hydrological time series, like river flow or level time series. Conversely, they are not able to model the behaviour of intermittent time series, like point rainfall height series usually are, especially when recorded with short sampling time intervals. More useful for this issue are the so-called DRIP (Disaggregated Rectangular Intensity Pulse) and NSRP (Neymann-Scott Rectangular Pulse) model [Heneker et al., 2001; Cowpertwait et al., 2002], usually adopted to generate synthetic point rainfall series. In this paper, the DRIP model approach is adopted, in which the sequence of rain storms and dry intervals constituting the structure of rainfall time series is modeled as an alternating renewal process. Final aim of the study is to provide a useful tool to implement an early warning system for hydrogeological risk management. Model calibration has been carried out with hourly rainfall hieght data provided by the rain gauges of Campania Region civil

  7. Forecasting of Hourly Photovoltaic Energy in Canarian Electrical System

    Science.gov (United States)

    Henriquez, D.; Castaño, C.; Nebot, R.; Piernavieja, G.; Rodriguez, A.

    2010-09-01

    The Canarian Archipelago face similar problems as most insular region lacking of endogenous conventional energy resources and not connected to continental electrical grids. A consequence of the "insular fact" is the existence of isolated electrical systems that are very difficult to interconnect due to the considerable sea depths between the islands. Currently, the Canary Islands have six isolated electrical systems, only one utility generating most of the electricity (burning fuel), a recently arrived TSO (REE) and still a low implementation of Renewable Energy Resources (RES). The low level of RES deployment is a consequence of two main facts: the weakness of the stand-alone grids (from 12 MW in El Hierro up to only 1 GW in Gran Canaria) and the lack of space to install RES systems (more than 50% of the land protected due to environmental reasons). To increase the penetration of renewable energy generation, like solar or wind energy, is necessary to develop tools to manage them. The penetration of non manageable sources into weak grids like the Canarian ones causes a big problem to the grid operator. There are currently 104 MW of PV connected to the islands grids (Dec. 2009) and additional 150 MW under licensing. This power presents a serious challenge for the operation and stability of the electrical system. ITC, together with the local TSO (Red Eléctrica de España, REE) started in 2008 and R&D project to develop a PV energy prediction tool for the six Canarian Insular electrical systems. The objective is to supply reliable information for hourly forecast of the generation dispatch programme and to predict daily solar radiation patterns, in order to help program spinning reserves. ITC has approached the task of weather forecasting using different numerical model (MM5 and WRF) in combination with MSG (Meteosat Second Generation) images. From the online data recorded at several monitored PV plants and meteorological stations, PV nominal power and energy produced

  8. STRESSORS IN NURSING WITH DOUBLE OR MORE WORKING HOURS

    Directory of Open Access Journals (Sweden)

    Marlinir Bezerra de Lima

    2013-01-01

    Full Text Available Resumo Objetivo: investigar os principais agentes estressores nos trabalhadores de enfermagem com dupla ou mais jornada de trabalho; verificar os principais sinais e sintomas indicadores de estresse. Métodos: estudo descritivo, com abordagem quantitativa. Desenvolvido em um hospital público da região metropolitana de Fortaleza-CE. A amostra constitui-se de 30 profissionais, sendo 46,7% auxiliares de enfermagem, 33,3% enfermeiros e 20% técnicos. A coleta ocorreu de novembro a dezembro de 2008, por meio de questionário semi-estruturado. Resultados: 93,3% dos profissionais são do sexo feminino na faixa etária de 31-40 anos. O estudo revelou vários fatores levando ao estresse, com destaque para insatisfação salarial (83%, falta de lazer (73% e sobrecarga de trabalho (60%, potencialmente prejudiciais à qualidade da assistência. Conclusão: percebeu-se a escassez de tempo que os trabalhadores de enfermagem dedicam ao descanso, ao lazer, ao convívio em família e à sua qualificação profissional. Descritores: Saúde mental, Estresse Ocupacional, Enfermagem, Ambiente de trabalho.   Abstract Objective: To investigate the main stressors in nursing workers double or more working hours, check the main signs and symptoms indicative of stress. Methods: A descriptive study with quantitative approach. It was developed in a public hospital in the metropolitan region of Fortaleza. The sample consisted of 30 professionals, and 46.7% nursing auxiliaries, 33.3% nurses and 20% technical. The data was collected during November-December 2008, through semi-structured questionnaire. Results: 93.3% of professionals are women aged 31-40 years. The study revealed several factors leading to stress, especially wage dissatisfaction (83%, lack of leisure (73% and workload (60%, potentially damaging the quality of care. Conclusion: it was perceived scarcity of time that the nursing staff dedicated to rest, leisure, living with the family and their professional

  9. Comparative Evaluation of 2-Hour Rapid Diagnostic Algorithms for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin T.

    Science.gov (United States)

    McRae, Andrew D; Innes, Grant; Graham, Michelle; Lang, Eddy; Andruchow, James E; Yang, Hong; Ji, Yunqi; Vatanpour, Shabnam; Southern, Danielle A; Wang, Dongmei; Seiden-Long, Isolde; DeKoning, Lawrence; Kavsak, Peter

    2017-08-01

    Symptoms of acute coronary syndrome account for a large proportion of emergency department (ED) visits and hospitalizations. High-sensitivity troponin can rapidly rule out or rule in acute myocardial infarction (AMI) within a short time of ED arrival. We sought to validate test characteristics and classification performance of 2-hour high-sensitivity troponin T (hsTnT) algorithms for the rapid diagnosis of AMI. We included consecutive patients from 4 academic EDs with suspected cardiac chest pain who had hsTnT assays performed 2 hours apart (± 30 minutes) as part of routine care. The primary outcome was AMI at 7 days. Secondary outcomes included major adverse cardiac events (mortality, AMI, and revascularization). Test characteristics and classification performance for multiple 2-hour algorithms were quantified. Seven hundred twenty-two patients met inclusion criteria. Seven-day AMI incidence was 10.9% and major adverse cardiac event incidence was 13.7%. A 2-hour rule-out algorithm proposed by Reichlin and colleagues ruled out AMI in 59.4% of patients with 98.7% sensitivity and 99.8% negative predictive value (NPV). The 2-hour rule-out algorithm proposed by the United Kingdom National Institute for Health and Care Excellence ruled out AMI in 50.3% of patients with similar sensitivity and NPV. Other exploratory algorithms had similar sensitivity but marginally better classification performance. According to Reichlin et al., the 2-hour rule-in algorithm ruled in AMI in 16.5% of patients with 92.4% specificity and 58.5% positive predictive value. Two-hour hsTnT algorithms can rule out AMI with very high sensitivity and NPV. The algorithm developed by Reichlin et al. had superior classification performance. Reichlin and colleagues' 2-hour rule-in algorithm had poor positive predictive value and might not be suitable for early rule-in decision-making. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  10. Evaluating the uncertainty of predicting future climate time series at the hourly time scale

    Science.gov (United States)

    Caporali, E.; Fatichi, S.; Ivanov, V. Y.

    2011-12-01

    A stochastic downscaling methodology is developed to generate hourly, point-scale time series for several meteorological variables, such as precipitation, cloud cover, shortwave radiation, air temperature, relative humidity, wind speed, and atmospheric pressure. The methodology uses multi-model General Circulation Model (GCM) realizations and an hourly weather generator, AWE-GEN. Probabilistic descriptions of factors of change (a measure of climate change with respect to historic conditions) are computed for several climate statistics and different aggregation times using a Bayesian approach that weights the individual GCM contributions. The Monte Carlo method is applied to sample the factors of change from their respective distributions thereby permitting the generation of time series in an ensemble fashion, which reflects the uncertainty of climate projections of future as well as the uncertainty of the downscaling procedure. Applications of the methodology and probabilistic expressions of certainty in reproducing future climates for the periods, 2000 - 2009, 2046 - 2065 and 2081 - 2100, using the 1962 - 1992 period as the baseline, are discussed for the location of Firenze (Italy). The climate predictions for the period of 2000 - 2009 are tested against observations permitting to assess the reliability and uncertainties of the methodology in reproducing statistics of meteorological variables at different time scales.

  11. A methodology for the stochastic generation of hourly synthetic direct normal irradiation time series

    Science.gov (United States)

    Larrañeta, M.; Moreno-Tejera, S.; Lillo-Bravo, I.; Silva-Pérez, M. A.

    2017-06-01

    Many of the available solar radiation databases only provide global horizontal irradiance (GHI) while there is a growing need of extensive databases of direct normal radiation (DNI) mainly for the development of concentrated solar power and concentrated photovoltaic technologies. In the present work, we propose a methodology for the generation of synthetic DNI hourly data from the hourly average GHI values by dividing the irradiance into a deterministic and stochastic component intending to emulate the dynamics of the solar radiation. The deterministic component is modeled through a simple classical model. The stochastic component is fitted to measured data in order to maintain the consistency of the synthetic data with the state of the sky, generating statistically significant DNI data with a cumulative frequency distribution very similar to the measured data. The adaptation and application of the model to the location of Seville shows significant improvements in terms of frequency distribution over the classical models. The proposed methodology applied to other locations with different climatological characteristics better results than the classical models in terms of frequency distribution reaching a reduction of the 50% in the Finkelstein-Schafer (FS) and Kolmogorov-Smirnov test integral (KSI) statistics.

  12. Decreased thalamocortical functional connectivity after 36 hours of total sleep deprivation: evidence from resting state FMRI.

    Directory of Open Access Journals (Sweden)

    Yongcong Shao

    Full Text Available OBJECTIVES: The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections, which hold a key function in segregating internally and externally directed awareness information. Previous task-related studies have revealed altered activities of the thalamus after total sleep deprivation (TSD. However, it is still unclear how TSD impacts on the communication between the thalamus and cerebral cortex. In this study, we examined changes of thalamocortical functional connectivity after 36 hours of total sleep deprivation by using resting state function MRI (fMRI. MATERIALS AND METHODS: Fourteen healthy volunteers were recruited and performed fMRI scans before and after 36 hours of TSD. Seed-based functional connectivity analysis was employed and differences of thalamocortical functional connectivity were tested between the rested wakefulness (RW and TSD conditions. RESULTS: We found that the right thalamus showed decreased functional connectivity with the right parahippocampal gyrus, right middle temporal gyrus and right superior frontal gyrus in the resting brain after TSD when compared with that after normal sleep. As to the left thalamus, decreased connectivity was found with the right medial frontal gyrus, bilateral middle temporal gyri and left superior frontal gyrus. CONCLUSION: These findings suggest disruptive changes of the thalamocortical functional connectivity after TSD, which may lead to the decline of the arousal level and information integration, and subsequently, influence the human cognitive functions.

  13. Salmonella identification from foods in eight hours: A prototype study with Salmonella Typhimurium

    Directory of Open Access Journals (Sweden)

    A Koluman

    2012-03-01

    Full Text Available Background and Objectives: The significant rise in food borne infections is mainly caused by Campylobacter spp., Salmonella serovars and Verotoxigenic Escherichia coli. As the emerging food borne pathogens cause disease, more studies have been conducted for rapid detection of these pathogens. The combination of immunomagnetic separation and polymerase chain reaction (IMS-PCR is the most accurate and rapid test preferred by almost every researcher. Fourier Transform Infrared Spectroscopy (FTIR is preferred for being a new, user friendly and rapid technique in microbiological analyses. The main aim of this study is to detect application of IMS-FTIR for Salmonella identification from foods in a short time with a higher sensitivity.Materials and Methods: Conventional Culture Technique (CC, IMS-CC, IMS-PCR and IMS-FTIR techniques were compared with each other for rapid detection in artificially contaminated minced beef with Salmonella Typhimurium, as of the 2nd, 4th and 8th hours of contamination. The method was evaluated in different food matrices and sensitivity, specifity and overall recovery was calculated.Results: The results indicate that IMS-FTIR can detect S. Typhimurium as of the 8th hour with sensitivity of 95.6667, accuracy of 91.69329, false positive ratio of 0.04333 and overall recovery of 95.66%.Conclusion: It can be suggested that the IMS-FTIR method is capable of detecting S.Typhimurium in a short time with lower cost.

  14. Salmonella identification from foods in eight hours: A prototype study with Salmonella Typhimurium

    Science.gov (United States)

    Koluman, A; Celik, G; Unlu, T

    2012-01-01

    Background and Objectives The significant rise in food borne infections is mainly caused by Campylobacter spp., Salmonella serovars and Verotoxigenic Escherichia coli. As the emerging food borne pathogens cause disease, more studies have been conducted for rapid detection of these pathogens. The combination of immunomagnetic separation and polymerase chain reaction (IMS-PCR) is the most accurate and rapid test preferred by almost every researcher. Fourier Transform Infrared Spectroscopy (FTIR) is preferred for being a new, user friendly and rapid technique in microbiological analyses. The main aim of this study is to detect application of IMS-FTIR for Salmonella identification from foods in a short time with a higher sensitivity. Materials and Methods Conventional Culture Technique (CC), IMS-CC, IMS-PCR and IMS-FTIR techniques were compared with each other for rapid detection in artificially contaminated minced beef with Salmonella Typhimurium, as of the 2nd, 4th and 8th hours of contamination. The method was evaluated in different food matrices and sensitivity, specifity and overall recovery was calculated. Results The results indicate that IMS-FTIR can detect S. Typhimurium as of the 8th hour with sensitivity of 95.6667, accuracy of 91.69329, false positive ratio of 0.04333 and overall recovery of 95.66%. Conclusion It can be suggested that the IMS-FTIR method is capable of detecting S.Typhimurium in a short time with lower cost. PMID:22783456

  15. Effectiveness of policies restricting hours of alcohol sales in preventing excessive alcohol consumption and related harms.

    Science.gov (United States)

    Hahn, Robert A; Kuzara, Jennifer L; Elder, Randy; Brewer, Robert; Chattopadhyay, Sajal; Fielding, Jonathan; Naimi, Timothy S; Toomey, Traci; Middleton, Jennifer Cook; Lawrence, Briana

    2010-12-01

    Local, state, and national policies that limit the hours that alcoholic beverages may be available for sale might be a means of reducing excessive alcohol consumption and related harms. The methods of the Guide to Community Preventive Services were used to synthesize scientific evidence on the effectiveness of such policies. All of the studies included in this review assessed the effects of increasing hours of sale in on-premises settings (in which alcoholic beverages are consumed where purchased) in high-income nations. None of the studies was conducted in the U.S. The review team's initial assessment of this evidence suggested that changes of less than 2 hours were unlikely to significantly affect excessive alcohol consumption and related harms; to explore this hypothesis, studies assessing the effects of changing hours of sale by less than 2 hours and by 2 or more hours were assessed separately. There was sufficient evidence in ten qualifying studies to conclude that increasing hours of sale by 2 or more hours increases alcohol-related harms. Thus, disallowing extensions of hours of alcohol sales by 2 or more should be expected to prevent alcohol-related harms, while policies decreasing hours of sale by 2 hours or more at on-premises alcohol outlets may be an effective strategy for preventing alcohol-related harms. The evidence from six qualifying studies was insufficient to determine whether increasing hours of sale by less than 2 hours increases excessive alcohol consumption and related harms.

  16. The Impact of Hospital Visiting Hour Policies on Pediatric and Adult Patients and their Visitors.

    Science.gov (United States)

    Smith, Lisa; Medves, Jennifer; Harrison, Margaret B; Tranmer, Joan; Waytuck, Brett

    2009-01-01

    acute care hospital wards. Finally, delivery rooms were excluded because this review does not evaluate the impact of the outcomes of presence during "delivery" (or other "procedures").Types of interventions Studies were considered for inclusion in this review if they evaluated the effect or impact of visiting policies. This included interventions targeted at limiting or expanding patient visiting. We anticipated a paucity of experimental studies regarding this review question, thus included observational studies where the impact of visiting policy on patients and/or visitors was a focus, but testing intervention(s) may not have been the primary aim. We did not consider observational studies that focused only on the presence of visitors during specific procedures, resuscitation, or childbirth. The reason is that this limited aspect of the presence of a significant other was not considered "visiting" per se, and would be best examined in another systematic review.Types of outcome measures For this review, outcome measures related to both patients and visitors as a result of visiting hour policies were considered, including but not limited to: patient and/or visitor satisfaction; attitudes; beliefs; perceptions; mood; or patient physiological outcomes. These also included health care provider beliefs, perceptions, and attitudes about the impact of visiting policies on patients and/or visitors. Studies were excluded if they examined the trend of current visiting hour policies (with no evaluation of their impact), or if they focused on visitor presence only during emergency procedures, resuscitation, or childbirth.Types of studies Randomized controlled trials (RCTs) or quasi-experimental studies were included. However, given the expected scarcity of these designs relevant to our review question, other quantitative research designs were considered, such as non-randomized controlled trials, before-and-after studies, and descriptive/observational studies. Using a defined search

  17. 42 CFR 84.252 - Gas masks; requirements and tests.

    Science.gov (United States)

    2010-10-01

    ... penetration after six hours of testing according to paragraph (b)(3) of this section shall not exceed 1 ppm... than four hours, the period of time for testing for vinyl chloride penetration will be performed at 150... penetration after nine hours of testing shall not exceed 1 ppm vinyl chloride.)...

  18. CMAQv5.1 Base NEIv1 AQS hourly site compare files

    Data.gov (United States)

    U.S. Environmental Protection Agency — CMAQv5.1 Base NEIv1 AQS hourly sitex files containing hourly paired model/ob data for the AQS network. This dataset is associated with the following publication:...

  19. Part 6: GPS Telemetry Detection Rates (Cougar FSR by Hour), GCS NAD83 (2015)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Cougar GPS collar fix success varied by hour-of-day suggesting circadian rhythms with bouts of rest during daylight hours may change the orientation of the GPS...

  20. 29 CFR 778.406 - Nonovertime hours as well as overtime hours must be irregular if section 7(f) is to apply.

    Science.gov (United States)

    2010-07-01

    ... (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Exceptions From the Regular Rate Principles Guaranteed Compensation Which Includes Overtime Pay § 778.406 Nonovertime hours as well as overtime...

  1. Comparisons of psychosomatic health and unhealthy behaviors between cleanroom workers in a 12-hour shift and those in an 8-hour shift.

    Science.gov (United States)

    Yamada, Y; Kameda, M; Noborisaka, Y; Suzuki, H; Honda, M; Yamada, S

    2001-12-01

    The General Health Questionnaire (GHQ12) and physical fitness tests were administered to 338 workers in clean rooms producing electronic parts in 12-h shifts. The results were compared to those in 95 workers in 8-h shifts and 284 daytime management, clerical and engineering workers. The 12-h shift workers complained of poor health, dissatisfaction with life and poor recuperation from fatigue more than the 8-h shift workers although the rates of complaints were highest in the daytime workers. The GHQ scores were similar in the two shift groups, and much better than those in the daytime workers. However, the 12-h shift workers showed significantly lower fitness levels than the 8-h shift workers, and the levels were even worse than the daytime workers who had higher mean age and BMI levels compared with the shift workers. The tendency to have sedentary freetime activities and larger alcohol and cigarette consumption were observed in the 12-h shift workers. The 12-h shift work may have contributed to the unhealthy behaviors resulting in lower physical fitness levels. Health promotion services at the workplace should devote greater attention to long-hour shift workers, together with devising the ways to improve working conditions and environments for reducing fatigue at work.

  2. Flexible Work Hours and Other Job Factors in Parental Time with Children

    Science.gov (United States)

    Baxter, Jennifer

    2011-01-01

    Flexible working hours are typically seen to be advantageous to working parents, as the flexible hours more easily allow responsibilities of care and employment be balanced. But do flexible work hours actually mean that parents can spend more time with their children? This article explores this for parents of young children in Australia. The…

  3. Optimal staffing under an annualized hours regime using Cross-Entropy optimization

    NARCIS (Netherlands)

    van der Veen, Egbert; Boucherie, Richardus J.; van Ommeren, Jan C.W.

    This paper discusses staffing under annualized hours. Staffing is the selection of the most cost-efficient workforce to cover workforce demand. Annualized hours measure working time per year instead of per week, relaxing the restriction for employees to work the same number of hours every week. To

  4. A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.

    Directory of Open Access Journals (Sweden)

    Eirini Kalliolia

    Full Text Available Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to hypothalamic pathology and dysfunction of hypothalamo-pituitary axes.We studied neuroendocrine profiles of corticotropic, somatotropic and gonadotropic hypothalamo-pituitary axes hormones over a 24-hour period in controlled environment in 15 healthy controls, 14 premanifest and 13 stage II/III Huntington's disease subjects. We also quantified fasting levels of vasopressin, oestradiol, testosterone, dehydroepiandrosterone sulphate, thyroid stimulating hormone, free triiodothyronine, free total thyroxine, prolactin, adrenaline and noradrenaline. Somatotropic axis hormones, growth hormone releasing hormone, insulin-like growth factor-1 and insulin-like factor binding protein-3 were quantified at 06:00 (fasting, 15:00 and 23:00. A battery of clinical tests, including neurological rating and function scales were performed.24-hour concentrations of adrenocorticotropic hormone, cortisol, luteinizing hormone and follicle-stimulating hormone did not differ significantly between the Huntington's disease group and controls. Daytime growth hormone secretion was similar in control and Huntington's disease subjects. Stage II/III Huntington's disease subjects had lower concentration of post-sleep growth hormone pulse and higher insulin-like growth factor-1:growth hormone ratio which did not reach significance. In Huntington's disease subjects, baseline levels of hypothalamo-pituitary axis hormones measured did not significantly differ from those of healthy controls.The relatively small subject group means that the study may not detect subtle perturbations in hormone concentrations. A targeted study of the somatotropic axis in larger cohorts may be warranted. However, the lack of significant results despite many

  5. Change in working characteristics of the steam turbine metal with operating time of more than 330000 hours

    Science.gov (United States)

    Gladshteyn, V. I.; Troitskiy, A. I.

    2017-01-01

    Research of a metal of the stop valve case (SVC) of the K-300-23.5 LMZ turbine (steel grade 15Kh1M1FL), destroyed after operation for 331000 hours, is performed. It's chemical composition and properties are determined as follows: a short-term mechanical tensile stress at 20°C and at elevated temperature, critical temperature, fragility, critical crack opening at elevated temperature, and long-term strength. Furthermore, nature of the microstructure, packing density of carbide particles and their size, and chemical composition of carbide sediment are estimated. A manifestation of metal properties for the main case components by comparison with a forecast of the respective characteristics made for the operating time of 331000 hours is tested. Property-time relationships are built for the forecast using statistical treatment of the test results for the samples cut out from more than 300 parts. Representativeness of the research results is proved: the statistical treatment of their differences are within the range of ±5%. It has been found that, after 150000 hours of operation, only the tensile strength insignificantly depends on the operating time at 20°C, whereas indicators of strength at elevated temperature significantly reduce, depending on the operating time. A brittle-to-ductile transition temperature (BDTT) raises, a critical notch opening changes in a complicated way, a long-term strength reduces. It has been found empirically that the limit of a long-term strength of the SVC metal at 540°C and the operating time of 105 hours is almost 1.6 times less than the required value in the as-delivered state. It is possible to evaluate a service life of the operating valves with the operating time of more than 330000 hours with respect to the long-term strength of the metal taking into account the actual temperature and stress. Guidelines for the control of similar parts are provided.

  6. Neurotrophic peptide ACTH-(4–10) permits glucocorticoid-facilitated retention of acquired immobility response of hypophysectomized rats

    NARCIS (Netherlands)

    Kock, S. de; Kloet, E.R. de

    1987-01-01

    The Porsolt swimming test, which was originally designed as an experimental model to screen potential antidepressants demands that rats be forced to swim for 15 min in a narrow cylinder. Twenty four hours later they are retested for 5 min during which they stay immobile for approximately 70% of the

  7. 33 CFR 159.103 - Vibration test.

    Science.gov (United States)

    2010-07-01

    ...) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.103 Vibration test. The device... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Vibration test. 159.103 Section... subjected to a sinusoidal vibration for a period of 12 hours, 4 hours in each of the x, y, and z planes, at...

  8. Quantitative and qualitative perceptions of the 2011 residency duty hour restrictions: a multicenter, multispecialty cross-sectional study.

    Science.gov (United States)

    Tierney, William S; Elkin, Rachel L; Nielsen, Craig D

    2015-03-25

    July 2011 saw the implementation of the newest duty hour restrictions, further limiting the working hours of first year residents and necessitating a variety of adaptations on the part of residency programs. The present study sought to characterize the perceived impact of these restrictions on residency program personnel using a multi-specialty and multi-site approach. We developed and administered a survey to internal medicine and general surgery residency programs at three academic medical centers within an urban region. The survey combined quantitative and qualitative components to gain a broader understanding of the impact of the newest regulations. Quantitative responses were compared between Internal Medicine and General Surgery programs with Student t-tests. Other comparisons were performed using ANOVA or Kruskal-Wallis testing as appropriate. For all comparisons, the threshold for significance was set at 0.01. Two independent reviewers coded all qualitative data and assigned one or more themes based on content. Descriptive statistics were calculated and the diversity of themes identified. No between-group comparisons were conducted with the qualitative data. We found significant differences in the overall perceptions of duty hour restrictions across specialty (internal medicine more positive than general surgery) and across position (first year residents more positive than senior residents and faculty). Notably, individuals who trained at osteopathic medical schools reported significantly more negative views of the duty hour restrictions than those who had trained at allopathic or international medical schools, suggesting an influence of undergraduate medical training. The complementary qualitative data offered insights into the perceived strengths and weaknesses of the duty hour restrictions, as well as actionable suggestions that could help to improve residency program function. This study characterizes responses to the new duty hour restrictions from a

  9. EDTA improves stability of whole blood C-peptide and insulin to over 24 hours at room temperature.

    Directory of Open Access Journals (Sweden)

    Timothy J McDonald

    Full Text Available INTRODUCTION: C-peptide and insulin measurements in blood provide useful information regarding endogenous insulin secretion. Conflicting evidence on sample stability and handling procedures continue to limit the widespread clinical use of these tests. We assessed the factors that altered the stability of insulin and C-peptide in blood. METHODS: We investigated the impact of preservative type, time to centrifugation, storage conditions and duration of storage on the stability of C-peptide and insulin on three different analytical platforms. RESULTS: C-peptide was stable for at least 24 hours at room temperature in both centrifuged and whole blood collected in K(+-EDTA and serum gel tubes, with the exception of whole blood serum gel, which decreased to 78% of baseline at 24 hours, (p = 0.008. Insulin was stable at room temperature for 24 hours in both centrifuged and whole blood collected in K(+-EDTA tubes. In contrast insulin levels decreased in serum gel tubes both centrifuged and whole blood (66% of baseline, p = 0.01 and 76% of baseline p = 0.01, by 24 hours respectively. C-peptide and insulin remained stable after 6 freeze-thaw cycles. CONCLUSIONS: The stability of C-peptide and insulin in whole blood K(+-EDTA tubes negates the need to conform to strict sample handling procedures for these assays, greatly increasing their clinical utility.

  10. Comparison of rate assessment between resting heart rate and 24-hour Holter monitoring in patients with chronic atrial fibrillation.

    Science.gov (United States)

    Srisukwattana, Akanis; Krittayaphong, Rungroj

    2012-02-01

    Target heart rate in rate control strategy has been proposed by the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. There is limited data on the correlation of measured heart rate at rest and during Holter monitoring. To evaluate the proportion of achieved target heart rate between resting heart rate measuring and 24-hour Holter monitoring in patients with chronic atrial fibrillation who receive rate control strategy. Patients with chronic atrial fibrillation who archived target resting heart rate under rate control strategy at Siriraj Hospital and who underwent 24-hour Holter monitoring were studied to evaluate the correlation between two methods of heart rate control. 47 patients were enrolled. Underlying cardiac conditions were as follows: hypertensive heart disease 44.7%, valvular heart disease 25%, coronary artery disease 17% and dilated cardiomyopathy 12.8%. There were 10 patients (21.3%) whose achieving target resting heart rate was not correlated with 24-hour Holter monitoring. Three patients (6.4%) underwent permanent pacemaker implantation due to sick sinus syndrome (SSS) or tachycardia-bradycardia syndrome. In chronic atrial fibrillation patients that receive rate control strategy, evaluation of only resting heart rate might not be enough for long-term evaluation and treatment and 24-hour monitoring may be an additional helpful test in order to more precisely adjust medication for long-term treatment and detection of SSS.

  11. Comparing the monitoring of patients transferred from a critical care unit to hospital wards at after-hours with day transfers: an exploratory, prospective cohort study.

    Science.gov (United States)

    Wood, Sally D; Coster, Samantha; Norman, Ian

    2014-12-01

    To investigate possible factors related to patient monitoring to explain the higher mortality rates associated with after-hours transfers compared with daytime transfers from critical care units to the wards. International research suggests that patients transferred from critical care units after-hours have a higher mortality rate than transfers during daytime, although the reasons remain unknown. A prospective exploratory study. Twenty-nine patients transferred from a UK critical care unit to a ward within the same hospital after-hours for 10 weeks beginning April 2009 were compared with 29 transfers during daytime hours matched on potentially confounding characteristics. UK Critical Care Unit transfer guidelines have remained unchanged since data collection. Outcomes were as follows: (i) frequency of nursing observations; (ii) time periods from transfer to first medical review; (iii) time period from transfer to first clinical observations; (iv) frequency of transfer to an inappropriate ward; (v) delayed transfers from Critical Care Unit to ward. Using Wilcoxon's Rank test (two tail) to compare paired data from the matched groups, observations were recorded significantly less frequently within the first 12 hours for after-hours transfers. Time from transfer to first clinical observations was significantly longer for after-hour transfer patients. The delay from when the patient was ready for ward care and actual transfer was also longer for the after-hours transfer group. Surveillance differences, including time to the first set of observations and frequency of observations in the first 12 hours, are potential factors that may explain the differential mortality associated with after-hours transfers. © 2014 John Wiley & Sons Ltd.

  12. 24-HOUR DIFFUSIVE SAMPLING OF 1,3-BUTADIENE IN AIR ONTO CARBONPAK X SOLID ADSORBENT WITH THEMAL DESORPTION/GC/MS ANALYSIS - FEASIBILITY STUDIES

    Science.gov (United States)

    Diffusive sampling of 1,3-butadiene for 24 hours onto the graphitic adsorbent Carbopack X contained in a stainless steel tube badge (6.3 mm OD, 5 mm ID, and 90 mm in length) with analysis by thermal desorption/GC/MS has been evaluated in controlled tests. A test matrix of 42 tr...

  13. Accumulated chilling hours during endodormancy impact blooming and fruit shape developmentin peach (Prunus persicaL.)

    Institute of Scientific and Technical Information of China (English)

    LI Yong; FANG Wei-chao; ZHU Geng-rui; CAO Ke; CHEN Chang-wen; WANG Xin-wei; WANG Li-rong

    2016-01-01

    Winter chil is essential for the growth and development of deciduous species. To understand the relationship between accumulated chiling hours during endodormancy and blooming and fruit shape development, we controled chiling hours and investigated their effects on blooming date and fruit shape of peaches. The results showed that the number of days to full bloom date and the heat requirement for blooming were negatively correlated with accumulated chilling hours. Accumulated chiling hours were signiifcantly negatively correlated with fruit shape index and fruit tip lengths, suggesting that the number of chiling hours affect the fruit shape development. Fewer accumulated chiling hours may be the major reason for longer fruit shape and protruding fruit tips. In conclusion, our results indicate speciifcaly that decreased winter chiling hours can delay the bloom date and may lead to aberrant fruit shape development in peaches. Our study provides preliminary insights into the response of temperate fruit species to global climate change.

  14. Fasting and 2-Hour Plasma Glucose and Insulin

    Science.gov (United States)

    Libman, Ingrid M.; Barinas-Mitchell, Emma; Bartucci, Andrea; Chaves-Gnecco, Diego; Robertson, Robert; Arslanian, Silva

    2010-01-01

    OBJECTIVE To determine whether elevated fasting or 2-h plasma glucose and/or insulin better reflects the presence of cardiovascular disease (CVD) risk markers in an overweight pediatric population with normal glucose tolerance. RESEARCH DESIGN AND METHODS A total of 151 overweight youths (8–17 years old) were evaluated with oral glucose tolerance tests and measurement of CVD risk factors. The study population was categorized according to quartiles of fasting and 2-h glucose and insulin levels. ANCOVA, adjusted for age, sex, race, Tanner stage, and percent body fat (measured by dual-energy X-ray absorptiometry), was used to compare metabolic variables between the quartiles of glucose and insulin groups. RESULTS Increasing quartiles of fasting and 2-h insulin were associated with increasing CVD risk factors. Glucose quartiles on the other hand, either fasting or at 2 h, were not. CONCLUSIONS These data suggest that hyperinsulinemia may be the earliest and/or primary metabolic alteration in childhood associated with risk markers for CVD. Prospective studies are needed. PMID:21115769

  15. Nanotoxicology and in vitro studies: The need of the hour

    Energy Technology Data Exchange (ETDEWEB)

    Arora, Sumit; Rajwade, Jyutika M.; Paknikar, Kishore M., E-mail: kpaknikar@gmail.com

    2012-01-15

    Nanotechnology is considered as one of the key technologies of the 21st century and promises revolution in our world. Objects at nano scale, take on novel properties and functions that differ markedly from those seen in the corresponding bulk counterpart primarily because of their small size and large surface area. Studies have revealed that the same properties that make nanoparticles so unique could also be responsible for their potential toxicity. Nanotechnology is rapidly advancing, with more than 1000 nanoproducts already on the market. Considering the fact that intended as well as unintended exposure to nanomaterials is increasing and presently no clear regulatory guideline(s) on the testing/evaluation of nanoparticulate materials are available, the in vitro toxicological studies become extremely relevant and important. This review presents a summary of nanotoxicology and a concise account of the in vitro toxicity data on nanomaterials. For nanomaterials to move into the applications arena, it is important that nanotoxicology research uncovers and understands how these multiple factors influence their toxicity so that the ensuing undesirable effects can be avoided.

  16. Surgical resident learning styles have changed with work hours.

    Science.gov (United States)

    Quillin, Ralph C; Cortez, Alexander R; Pritts, Timothy A; Hanseman, Dennis J; Edwards, Michael J; Davis, Bradley R

    2016-01-01

    The Accreditation Council for Graduate Medical Education instituted the 80-h workweek for residency programs in 2003. This presented a unique challenge for surgery residents who must acquire a medical and technical knowledge base during training. Therefore, learning should be delivered in an environment congruent with an individual's learning style. In this study, we evaluated the learning styles of general surgery residents to determine how learning styles changed after the implementation to the 80-h workweek. Kolb learning style inventory was taken by general surgery residents at the University of Cincinnati's Department of Surgery, and results from 1999-2012 were analyzed. Statistical analysis was performed using the chi-squared, logistic regression and Wilcoxon rank-sum test. Significance was defined as a P value of learning styles after the institution of the 80-h workweek to converging (43.9%) and accommodating (40.4%, P learning. This change paralleled the transition to a more team-based approach to patient care with the implementation of the 80-h workweek. These findings are important for surgical educators to consider in the development of surgical resident curriculum. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Image, Imagery Thinking and the Twenty -four Poetry Style%意象、意象思维与《二十四诗品》

    Institute of Scientific and Technical Information of China (English)

    金路杰

    2012-01-01

    Imagery thinking is the unique ancient Chinese way of thinking, both in poetry writing and poetry review. The author uses images to express his mind. Sikong Tu's Twenty -Your Poetry Style in the Tang Dynasty is absolutely the aesthetic model in which there are intensive image groups constituted by the refining phrases in the text, in order to reflect the classical poetics. On the other hand, Sikong Tu is not only a theorist but also a poet; the book contains a profound meaning.%意象思维是中国古代特有一种思维方式,无论是诗歌创作还是诗学评论,即通过意象来表达作者的情思。唐代司空图的《二十四诗品》无疑就是其中的美学典范,文本中有着大量的精炼性词组构成的密集意象群,以此来体现古典文人的诗歌创作论和诗歌批评论。同时由于司空图的妙笔生花,《诗品》集诗学与诗歌一体的文本特殊性,又分析了《诗品》意象下所隐含的精神内涵。

  18. Moderate to severe injuries in football: a one-year prospective study of twenty-four female and male amateur teams.

    Science.gov (United States)

    Lion, Alexis; Theisen, Daniel; Windal, Thierry; Malisoux, Laurent; Nührenbörger, Christian; Huberty, Robert; Urhausen, Axel; Seil, Romain

    2014-01-01

    This study aimed to realize a prospective follow-up of the injuries occurring in female and male football players involved in the highest league in the Grand-Duchy of Luxembourg. Data concerning anthropometric characteristics and football activities were gathered in 125 female and 243 male football players via questionnaires at the beginning of the study. Then, a follow-up of moderate to severe injuries (> 15 days of interruption in football practice) was performed throughout the season 2013-2014. Sixteen injuries (injury incidence = 0.7 injuries/1000 h of exposure) were observed in 13 female football players (10.4%). These injuries concerned mainly the knee (n = 7; 43.7%), with capsules and ligaments being the most often concerned tissues (n = 7; 43.7%). In male football players, 41 severe injuries (injury incidence = 0.6 injuries/1000 h of exposure) were observed in 36 players (14.8%). These injuries concerned mainly the thighs (n = 12; 29.3%) and the muscles and tendons were the most often concerned tissues (n = 18; 43.9%). Injuries in football are predominantly located at the lower limbs, particularly the knees in female football players. The predominant muscle and tendon lesions of the thighs occurring in males could reveal that physical preparation is insufficient or inadequate for a number of players. Regarding these results, it is necessary to implement an injury prevention strategy. The "FIFA 11+" programme could be used as the basic method, but should be personalized according to sex. The injury collection methodology could be optimized with the use of an electronic database, such as the Training and Injury Prevention Platform for Sports (TIPPS). Beside the systematic recording of injury data (as well as the training load) by the players or the medical staff, this system allows to share of important information between stakeholders, follow-up the players, provide risk factor warnings and increase the awareness of the injury problem.

  19. Clinical, functional and genetic analysis of twenty-four patients with chronic granulomatous disease - identification of eight novel mutations in CYBB and NCF2 genes.

    Science.gov (United States)

    Martel, Cécile; Mollin, Michelle; Beaumel, Sylvain; Brion, Jean Paul; Coutton, Charles; Satre, Véronique; Vieville, Gaëlle; Callanan, Mary; Lefebvre, Christine; Salmon, Alexandra; Pagnier, Anne; Plantaz, Dominique; Bost-Bru, Cécile; Eitenschenck, Laurence; Durieu, Isabelle; Floret, Daniel; Galambrun, Claire; Chambost, Hervé; Michel, Gérard; Stephan, Jean-Louis; Hermine, Olivier; Blanche, Stéphane; Blot, Nathalie; Rubié, Hervé; Pouessel, Guillaume; Drillon-Haus, Stephanie; Conrad, Bernard; Posfay-Barbe, Klara M; Havlicekova, Zuzana; Voskresenky-Baricic, Tamara; Jadranka, Kelecic; Arriazu, Maria Cristina; Garcia, Luis Alberto; Sfaihi, Lamia; Mansour, Lamia Sfaihi Ben; Bordigoni, Pierre; Stasia, Marie José

    2012-10-01

    Chronic granulomatous disease is an inherited disorder in which phagocytes lack a functional NADPH oxidase and cannot produce superoxide anions. The most common form is caused by mutations in CYBB encoding gp91phox. We investigated 24 CGD patients and their families. Twenty-one mutations in CYBB were classified as X91(0), X91(+) or X91(-) variants according to cytochrome b (558) expression. Point mutations in encoding regions represented 50 % of the mutations found in CYBB, splice site mutations 27 %, deletions and insertions 23 %. Eight mutations in CYBB were novel leading to X91(0)CGD cases. Two of these were point mutations: c493G>T and a double mutation c625C>G in exon 6 and c1510C>T in exon 12 leading to a premature stop codon at Gly165 in gp91phox and missense mutations His209Arg/Thr503Ile respectively. Two novel splice mutations in 5'intronic regions of introns 1 and 6 were found. A novel deletion/insertion c1024_1026delCTG/insT results in a frameshift introducing a stop codon at position 346 in gp91phox. The last novel mutation was the insertion of a T at c1373 leading to a frameshift and a premature stop codon at position 484 in gp91phox. For the first time the precise size of two large mutations in CYBB was determined by array-comparative genomic hybridization and carriers' status were evaluated by multiplex ligation-dependent probe amplification assay. No clear correlation between clinical severity and CYBB mutations could be established. Of three mutations in CYBA, NCF1 and NCF2 leading to rare autosomal recessive CGD, one nonsense mutation c29G>A in exon 1 of NCF2 was new.

  20. Correlations between phenolic content and antioxidant properties in twenty-four plant species of traditional ethnoveterinary use in the Mediterranean area.

    Science.gov (United States)

    Piluzza, Giovanna; Bullitta, Simonetta

    2011-03-01

    Scientific information on antioxidant properties and phenolic content of less widely used plants can be useful. Therefore, the assessment of such properties remains an interesting and useful task, particularly for finding new sources for natural antioxidants, functional foods, and nutraceuticals. As knowledge about antioxidant properties and phenolic content of many plant species used as traditional plant remedies is limited, we determined in vitro the total antioxidant activity and the phenolic content of several plant species traditionally used for ethnoveterinary practices. For 24 extracts (70% acetone) from wild and cultivated plant species traditionally used for health care of animals we determined the Trolox equivalent antioxidant capacity (TEAC) by the two assays 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the 2,2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS). The phenolic content was determined by the Folin Ciocalteu method. Total phenolics, calculated as gallic acid equivalent (GAE), showed variation ranging from 3.18 (Allium sativum L. (Liliaceae)) to 147.68 (Pistacia lentiscus L. (Anacardiaceae)) mgGAE/g dry weight (DW). High TEAC values corresponded to high phenolic content, while plants with low antioxidant activity exhibited low total phenolic content. The TEAC determined through each assay and total phenolic content were positively correlated, R² = 0.9152 and R² = 0.8896, respectively, for DPPH and ABTS assay. These findings suggest that phenolic content could be used as an indicator of antioxidant properties. The results of this study encourage investigations on Mediterranean plant species as sources of antioxidants.