WorldWideScience

Sample records for twenty modules developed

  1. Identity Development in the Late Twenties: A Never Ending Story

    Science.gov (United States)

    Carlsson, Johanna; Wängqvist, Maria; Frisén, Ann

    2015-01-01

    The aim of this study was to investigate identity development in the late 20s in order to learn more about the continued identity development after identity commitments have been made. The starting point for the study was the contradiction between ideas of identity development as a lifelong process and identity status research showing that…

  2. Multichip module technology development

    Energy Technology Data Exchange (ETDEWEB)

    Kapustinsky, J.S.; Boissevain, J.G.; Muck, R.C.; Smith, G.D.; Wong-Swanson, B.G.; Ziock, H.J.

    1997-10-01

    This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). A Multichip Module (MCM) was designed and submitted for fabrication to the Lockheed Martin foundry using a licensed process called High Density Interconnect (HDI). The HDI process uses thin film techniques to create circuit interconnect patterns on multiple layers of dielectric film which are deposited directly on top of unpackaged electronic die. This results in an optimally small package that approaches the area of the bare die themselves. This project tested the capability of the Lockheed Martin foundry to produce, in an HDI process, a complex mixed-mode (analog and digital) circuit on a single MCM substrate.

  3. Thin film module development

    Science.gov (United States)

    Jester, T.

    1985-01-01

    The design of ARCO Solar, Inc.'s Genesis G100 photovoltaic module was driven by several criteria, including environmental stability (both electrical and mechanical), consumer aesthetics, low materials costs, and manufacturing ease. The module circuitry is designed as a 12 volt battery charger, using monolithic patterning techniques on a glass superstrate. This patterning and interconnect method proves amenable to high volume, low cost production throughput, and the use of glass serves the dual role of handling ease and availability. The mechanical design of the module centers on environmental stability. Packaging of the glass superstrate circuit must provide good resistance to thermal and humidity exposure along with hi-pot insulation and hailstone impact resistance. The options considered are given. Ethylene vinyl acetate (EVA) is chosen as the pottant material for its excellent weatherability.

  4. Stirling Module Development Overview

    Science.gov (United States)

    Livingston, F. R.

    1984-01-01

    The solar parabolic dish Stirling engine electrically generating module consists of a solar collector coupled to a Stirling engine powered electrical generator. The module is designed to convert solar power to electrical power in parallel with numerous identical units coupled to an electrical utility power grid. The power conversion assembly generates up to 25 kilowatts at 480 volts potential/3 phase/alternating current. Piston rings and seals with gas leakage have not occurred, however, operator failures resulted in two burnt out receivers, while material fatigue resulted in a broken piston rod between the piston rod seal and cap seal.

  5. Development of GREET Catalyst Module

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhichao [Argonne National Lab. (ANL), Argonne, IL (United States); Benavides, Pahola T. [Argonne National Lab. (ANL), Argonne, IL (United States); Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States); Cronauer, Donald C. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    In this report, we develop energy and material flows for the production of five different catalysts (tar reforming, alcohol synthesis, Zeolite Socony Mobil-5 [ZSM-5], Mo/Co/ γ-Al2O3, and Pt/ γ-Al2O3) and two chemicals (olivine, dimethyl ether of polyethylene glycol [DEPG]). These compounds and catalysts are now included in the Greenhouse Gases, Regulated Emissions and Energy Use in Transportation (GREET™) catalyst module.

  6. Development of GREET Catalyst Module

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhichao [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division; Cronauer, Donald C. [Argonne National Lab. (ANL), Argonne, IL (United States). Energy Systems Division

    2014-09-01

    Catalysts are critical inputs for many pathways that convert biomass into biofuels. Energy consumption and greenhouse gas (GHG) emissions during the production of catalysts and chemical inputs influence the life-cycle energy consumption, and GHG emissions of biofuels and need to be considered in biofuel life-cycle analysis (LCA). In this report, we develop energy and material flows for the production of three different catalysts (tar reforming, alcohol synthesis, Zeolite Socony Mobil-5 [ZSM-5]) and two chemicals (olivine, dimethyl ether of polyethylene glycol [DEPG]). These compounds and catalysts are now included in the Greenhouse Gases, Regulated Emissions and Energy Use in Transportation (GREET™) catalyst module. They were selected because they are consumed in existing U.S. Department of Energy (DOE) analyses of biofuel processes. For example, a thermochemical ethanol production pathway (indirect gasification and mixed alcohol synthesis) developed by the National Renewable Energy Laboratory (NREL) uses olivine, DEPG, and tar reforming and alcohol synthesis catalysts (Dutta et al., 2011). ZSM-5 can be used in biofuel production pathways such as catalytic upgrading of sugars into hydrocarbons (Biddy and Jones, 2013). Other uses for these compounds and catalysts are certainly possible. In this report, we document the data sources and methodology we used to develop material and energy flows for the catalysts and compounds in the GREET catalyst module. In Section 2 we focus on compounds used in the model Dutta et al. (2011) developed. In Section 3, we report material and energy flows associated with ZSM-5 production. Finally, in Section 4, we report results.

  7. [Development of health promotion in Brazil in the last twenty years (1988-2008)].

    Science.gov (United States)

    Buss, Paulo Marchiori; Carvalho, Antonio Ivo de

    2009-01-01

    This paper examines the institutionalization of health promotion (HP) in Brazil in the twenty years following the proclamation of the 1988 Brazilian Constitution. The legal and institutional foundations of HP are delineated, as well as its recent reassertion as a national policy. Moreover, the praxis of HP within the health system and other instances are analyzed, and the institutional capacity building - by means of research and training of human resources - is examined. Around 100 papers were revised, including institutional policy documents, decrees, laws, and annals of congresses and other events. The authors' personal experience in the ideational conception of the area and in the institutionalization of health promotion as a public policy in the country was also drawn upon. Finally, major restrictions to the theoretical and practical development of health promotion are criticized and a few ideas that might benefit such development are presented.

  8. DEVELOPMENT OF THE INFORMATION COMPETENCE OF THE ACADEMIC COMMUNITY: TWENTY YEARS AFTER

    Directory of Open Access Journals (Sweden)

    Glosiene, Audrone

    2006-12-01

    Full Text Available Twenty years ago, reading culture, library skills’ development used to be one of the core directions in research and teaching policy of the Department of Library Science at Vilnius University. Lateron, the topic was marginalized and today we return to the field that meanwhile has developed huge knowledge and experience base worldwide. A stimulus for the return was participation in BIBLIONOVA project. The aim of the article is to present a holistic approach towards information competency development in a modern academic institution. Prescriptive approach based on information literacy standards proved to be limited and not always effective in the academic environment.Information competency development is problem-specific, domain-specific, and disciplinespecific. It is interrelated with critical thinking, analytical skills as well as creativity and computerliteracy skills. Holistically, information competency development is an integral part of university’s life-long learning strategy. Critical success factors for information competency development areopen and problem-based learning and cooperative, inclusive strategies of the whole university. Academic libraries continue to play a major role in the process but the connections with faculty and administration in the process are of major importance.

  9. Photovoltaic module energy rating methodology development

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, B.; Myers, D.; Emery, K.; Mrig, L. [National Renewable Energy Lab., Golden, CO (United States); Whitaker, C.; Newmiller, J. [Endecon Engineering, San Ramon, CA (United States)

    1996-05-01

    A consensus-based methodology to calculate the energy output of a PV module will be described in this paper. The methodology develops a simple measure of PV module performance that provides for a realistic estimate of how a module will perform in specific applications. The approach makes use of the weather data profiles that describe conditions throughout the United States and emphasizes performance differences between various module types. An industry-representative Technical Review Committee has been assembled to provide feedback and guidance on the strawman and final approach used in developing the methodology.

  10. Twenty-One: cross-language disclosure and retrieval of multimedia documents on sustainable development

    NARCIS (Netherlands)

    Stal, ter W.G.; Beijert, J.-H.; Bruin, de G.; Gent, van J.; Jong, de F.M.G.; Kraaij, W.; Netter, K.; Smart, G.

    1998-01-01

    The Twenty-One project brings together environmental organisations, technology providers and research institutes from several European countries. The main objective of the project is to make documents on environmental issues—in particular, on the subject of sustainable development—available on CD-RO

  11. Microfiltration : membrane development and module design

    NARCIS (Netherlands)

    Roesink, Hendrik Dirk Willem

    1989-01-01

    This thesis describes the development of a new type of hydrophilic microfiltration membranes and in addition some studies are presented, that may result in a completely new design of microfiltration modules containing capillary membranes.

  12. A Shift to Inquiry: The Heart of Effective Teaching and Professional Development for the Twenty-First Century

    Science.gov (United States)

    Bartolini, Vicki; Worth, Karen; Jensen LaConte, Judy E.

    2014-01-01

    This article explores how an experienced teacher navigates the demands of curriculum to implement her inquiry-centered teaching and learning philosophy, and how administrators along the way supported her during this change. Interviews with this classroom teacher surface suggestions for twenty-first-century professional development and support,…

  13. Evolution and modulation of tropical heating from the last glacial maximum through the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Hoyos, Carlos D.; Webster, Peter J. [Georgia Institute of Technology, School of Earth and Atmospheric Sciences, Atlanta, GA (United States)

    2012-04-15

    Twentieth century observations show that during the last 50 years the sea-surface temperature (SST) of the tropical oceans has increased by {proportional_to}0.5 C and the area of SST >26.5 and 28 C (arbitrarily referred to as the oceanic warm pool: OWP) by 15 and 50% respectively in association with an increase in green house gas concentrations, with non-understood natural variability or a combination of both. Based on CMIP3 projections the OWP is projected to double during twenty-first century in a moderate CO{sub 2} forcing scenario (IPCC A1B scenario). However, during the observational period the area of positive atmospheric heating (referred to as the dynamic warm pool, DWP), has remained constant. The threshold SST (T{sub H}), which demarks the region of net heating and cooling, has increased from 26.6 C in the 1950s to 27.1 C in the last decade and it is projected to increase to {proportional_to}28.5 C by 2100. Based on climate model simulations, the area of the DWP is projected to remain constant during the twenty-first century. Analysis of the paleoclimate model intercomparison project (PMIP I and II) simulations for the Last Glacial maximum and the Mid-Holocene periods show a very similar behaviour, with a larger OWP in periods of elevated tropical SST, and an almost constant DWP associated with a varying T{sub H}. The constancy of the DWP area, despite shifts in the background SST, is shown to be the result of a near exact matching between increases in the integrated convective heating within the DWP and the integrated radiative cooling outside the DWP as SST changes. Although the area of the DWP remains constant, the total tropical atmospheric heating is a strong function of the SST. For example the net heating has increased by about 10% from 1950 to 2000 and it is projected to increase by a further 20% by 2100. Such changes must be compensated by a more vigorous atmospheric circulation, with growth in convective heating within the warm pool, and an

  14. Getting started with Magento module development

    CERN Document Server

    Ajzele, Branko

    2013-01-01

    This project-based tutorial gives you a strong foundation and guides you through practical, real-world examples.This book contains valuable insights for both newbies and already established Magento developers. This book is targeted at new and intermediate PHP developers starting afresh with Magento module development.

  15. Software based controls module development

    Energy Technology Data Exchange (ETDEWEB)

    Graves, v.b.; kelley, g; welch, j.c.

    1999-12-10

    A project was initiated at the Oak Ridge Y-12 Plant to implement software geometric error compensation within a PC-based machine tool controller from Manufacturing Data Systems, Inc. This project may be the first in which this type of compensation system was implemented in a commercially available machine tool controller totally in software. Previous implementations typically required using an external computer and hardware to interface through the position feedback loop of the controller because direct access to the controller software was not available. The test-bed machine for this project was a 2-axis Excello 921 T-base lathe. A mathematical error model of the lathe was created using homogeneous transformation matrices to relate the positions of the machine's slides to each other and to a world reference system. Equations describing the effects of the geometric errors were derived from the model. A software architecture was developed to support geometric error compensation for machine tools with up to 3 linear axes. Rotary axes were not supported in this implementation, but the developed architecture would not preclude their support in the future. Specific implementations will be dependent upon the configuration of the machine tool. A laser measuring system from Automated Precision, Inc. was used to characterize the lathe's geometric errors as functions of axis position and direction of motion. Multiple data files generated by the laser system were combined into a single Error File that was read at system startup and used by the compensation system to provide real-time position adjustments to the axis servos. A Renishaw Ballbar was used to evaluate the compensation system. Static positioning tests were conducted in an attempt to observe improved positioning accuracy with the compensation system enabled. These tests gave inconsistent results due to the lathe's inability to position the tool repeatably. The development of the architecture and

  16. Development and validation of a yoga module for Parkinson disease.

    Science.gov (United States)

    Kakde, Noopur; Metri, Kashinath G; Varambally, Shivarama; Nagaratna, Raghuram; Nagendra, H R

    2017-03-25

    Background Parkinson's disease (PD), a progressive neurodegenerative disease, affects motor and nonmotor functions, leading to severe debility and poor quality of life. Studies have reported the beneficial role of yoga in alleviating the symptoms of PD; however, a validated yoga module for PD is unavailable. This study developed and validated an integrated yoga module(IYM) for PD. Methods The IYM was prepared after a thorough review of classical yoga texts and previous findings. Twenty experienced yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM. A total of 28 practices were included in the IYM, and each practice was discussed and rated as (i) not essential, (ii) useful but not essential, and (iii) essential; the content validity ratio (CVR) was calculated using Lawshe's formula. Results Data analysis revealed that of the 28 IYM practices, 21 exhibited significant content validity (cut-off value: 0.42, as calculated by applying Lawshe's formula for the CVR). Conclusions The IYM is valid for PD, with good content validity. However, future studies must determine the feasibility and efficacy of the developed module.

  17. Microfiltration: Membrane development and module design

    Science.gov (United States)

    Roesink, Hendrik Dirk Willem

    The development of a type of hydrophilic microfiltration membranes is described. Studies which may result in a design of microfiltration modules containing capillary membranes are presented. The membranes are prepared from a solution containing two polymers and are of flat or cylindrical geometry. Attention is focused an capillary membranes, which are tubular membranes of outer diameter 0.5 to 5 mm, prepared by means of a dry-wet spining process. Different flow conditions of the feed suspension in the modules are described. The most favorable configuration appears to be transverse flow. A model to calculate the pressure drop in the bore of the capillary membrane during filtration and backflushing is presented.

  18. Photovoltaic module certification/laboratory accreditation criteria development: Implementation handbook

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Laboratory, Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International, Inc., Tempe, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1996-08-01

    This document covers the second phase of a two-part program. Phase I provided an overview of the structure and function of typical product certification/laboratory accreditation programs. This report (Phase H) provides most of the draft documents that will be necessary for the implementation of a photovoltaic (PV) module certification/laboratory accreditation program. These include organizational documents such as articles of incorporation, bylaws, and rules of procedure, as well as marketing and educational program documents. In Phase I, a 30-member criteria development committee was established to guide, review and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories. A similar committee was established for Phase II; the criteria implementation committee consisted of 29 members. Twenty-one of the Phase I committee members also served on the Phase II committee, which helped to provide program continuity during Phase II.

  19. Photovoltaic module certification/laboratory accreditation criteria development: Implementation handbook

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Laboratory, Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International, Inc., Tempe, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1996-08-01

    This document covers the second phase of a two-part program. Phase I provided an overview of the structure and function of typical product certification/laboratory accreditation programs. This report (Phase H) provides most of the draft documents that will be necessary for the implementation of a photovoltaic (PV) module certification/laboratory accreditation program. These include organizational documents such as articles of incorporation, bylaws, and rules of procedure, as well as marketing and educational program documents. In Phase I, a 30-member criteria development committee was established to guide, review and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories. A similar committee was established for Phase II; the criteria implementation committee consisted of 29 members. Twenty-one of the Phase I committee members also served on the Phase II committee, which helped to provide program continuity during Phase II.

  20. Desirable properties of wood for sustainable development in the twenty-first century

    Science.gov (United States)

    Kenneth E. Skog; Theodore H. Wegner; Ted Bilek; Charles H. Michler

    2015-01-01

    We previously identified desirable properties for wood based on current market-based trends for commercial uses (Wegner et al. 2010). World business models increasingly incorporate the concept of social responsibility and the tenets of sustainable development. Sustainable development is needed to support an estimated 9 billion people by 2050 within the carrying...

  1. A Firefly Learning Module for Environmental Sustainable Development in Samutsongkhram Province, THAILAND

    Directory of Open Access Journals (Sweden)

    Jongdee To-im

    2012-01-01

    Full Text Available A firefly learning module for the sustainable development was developed for Thai secondary school students in the study province. A deeper connection between environment, social and economic dimensions, which lies at the core of sustainability, became the key issue for this learning module. Also an important dimension of the module was the empowerment of the students themselves. Through brainstorming and ensuring activities, students were expected to act at the local level and to develop a deeper sense of responsibility. This study aimed at to develop learning module based on both the principle of inquiry approaches and the collaboration of a community of learners. Mixed methods paradigm was employed for data collection and analysis. Four data collection techniques: classroom observations, interviews, written documents, and questionnaire were employed. The Statistical Package for the Social Sciences was applied for quantitative data analysis. The qualitative data were analyzed using open and axial coding techniques. The analyzed data were categorized to describe context of developed learning module, the students’ conceptual understanding, and awareness toward ecosystems and firefly conservation. The study involved one-9th grade class of twenty students from one school in Samutsongkhram Province, Thailand. The results indicated that the developed learning module improved students’ conceptual understanding, perceptions, and self-reported behavior toward ecosystems and firefly conservation. The results of the effectiveness of this learning module clearly showed that the students gained significantly higher score in conceptual understanding and perceptions after participating in this learning module. The results from interviews showed that the students changed from a poor to a very good level of understanding after involvement in this learning module. The results also indicated that none of the students remained at the poor level after

  2. Growth and development: hereditary and mechanical modulations.

    Science.gov (United States)

    Mao, Jeremy J; Nah, Hyun-Duck

    2004-06-01

    Growth and development is the net result of environmental modulation of genetic inheritance. Mesenchymal cells differentiate into chondrogenic, osteogenic, and fibrogenic cells: the first 2 are chiefly responsible for endochondral ossification, and the last 2 for sutural growth. Cells are influenced by genes and environmental cues to migrate, proliferate, differentiate, and synthesize extracellular matrix in specific directions and magnitudes, ultimately resulting in macroscopic shapes such as the nose and the chin. Mechanical forces, the most studied environmental cues, readily modulate bone and cartilage growth. Recent experimental evidence demonstrates that cyclic forces evoke greater anabolic responses of not only craniofacial sutures, but also cranial base cartilage. Mechanical forces are transmitted as tissue-borne and cell-borne mechanical strain that in turn regulates gene expression, cell proliferation, differentiation, maturation, and matrix synthesis, the totality of which is growth and development. Thus, hereditary and mechanical modulations of growth and development share a common pathway via genes. Combined approaches using genetics, bioengineering, and quantitative biology are expected to bring new insight into growth and development, and might lead to innovative therapies for craniofacial skeletal dysplasia including malocclusion, dentofacial deformities, and craniofacial anomalies such as cleft palate and craniosynostosis, as well as disorders associated with the temporomandibular joint.

  3. DEVELOPING EFFECTIVE ARMED FORCES IN THE TWENTY FIRST CENTURY CASE STUDIES OF NEW DEMOCRACIES

    Directory of Open Access Journals (Sweden)

    Florina Cristiana (Cris MATEI

    2011-01-01

    Full Text Available The purpose of this article is to contribute to a better understanding of thecontemporary value for democracy of the relationship between elected leadersand the armed forces. Hence, it focuses on the military effectiveness dimension ofthe CMR. It discusses why it is important and what newer democracies can do tosuccessfully develop effective armed forces. The article provides “lessons learned/best practices” of achieving effectiveness from three developing democracies - Chile,Hungary, and, Mongolia.

  4. Management of healthcare waste: developments in Southeast Asia in the twenty-first century.

    Science.gov (United States)

    Kühling, Jan-Gerd; Pieper, Ute

    2012-09-01

    In many Southeast Asian countries, significant challenges persist with regard to the proper management and disposal of healthcare waste. The amount of healthcare waste in these countries is continuously increasing as a result of the expansion of healthcare systems and services. In the past, healthcare waste, if it was treated at all, was mainly incinerated. In the last decade more comprehensive waste management systems were developed for Southeast Asian countries and implementation started. This also included the establishment of alternative healthcare waste treatment systems. The developments in the lower-middle-income countries are of special interest, as major investments are planned. Based upon sample projects, a short overview of the current development trends in the healthcare waste sector in Laos, Indonesia and Vietnam is provided. The projects presented include: (i) Lao Peoples Democratic Republic (development of the national environmental health training system to support the introduction of environmental health standards and improvement of healthcare waste treatment in seven main hospitals by introducing steam-based treatment technologies); (ii) Indonesia (development of a provincial-level healthcare waste-management strategy for Province Nanggroe Aceh Darussalam (NAD) and introduction of an advanced waste treatment system in a tertiary level hospital in Makassar); and (iii) Vietnam (development of a healthcare waste strategy for five provinces in Vietnam and a World Bank-financed project on healthcare waste in Vietnam).

  5. Developing instrumentation to characterize thermoelectric generator modules

    Science.gov (United States)

    Liu, Dawei; Li, Qiming; Peng, Wenbo; Zhu, Lianjun; Gao, Hu; Meng, Qingsen; Jin, A. J.

    2015-03-01

    Based on the law of physics, known as "Seebeck effect," a thermoelectric generator (TEG) produces electricity when the temperature differential is applied across the TEG. This article reports a precision method in characterizing TEG modules. A precision instrument is constructed to study thermoelectric conversion in terms of output power and efficiency of TEG modules. The maximum allowable TEG module size is 150 mm, and the preferred size is from 30 mm to 60 mm. During measurements, the highest hot side temperature is 500 °C and the cold side temperature can be adjusted from room temperature to 100 °C. A mechanical structure is developed to control the pressure and parallelism of the clamping force of the TEG on both its hot and cold sides. A heat flux measurement module is installed at its cold side, and the heat flux through TEGs can be measured in position. Finally, the energy conversion efficiency of TEGs is calculated from experimental data of both an output power and a heat flux.

  6. Exploring early twenty-first century developed forest camping experiences and meanings

    Science.gov (United States)

    Barry A. Garst; Daniel R. Williams; Joseph W. Roggenbuck

    2010-01-01

    This study examines experiences and associated meanings of 38 family groups participating in developed camping. The analysis is guided by discursive social psychology in which expressed meanings reflect interpretive frames campers use to explain experiences. Key elements of camping experience include nature, social interaction, and comfort/convenience. The most common...

  7. Gasification of waste. Summary and conclusions of twenty-five years of development

    Energy Technology Data Exchange (ETDEWEB)

    Rensfelt, Erik [TPS Termiska Processer AB, Nykoeping (Sweden); Oestman, Anders [Kemiinformation AB, Stockholm (Sweden)

    2000-04-01

    An overview of nearly thirty years development of waste gasification and pyrolysis technology is given, and some major general conclusions are drawn. The aim has been to give new developers an overview of earlier major attempts to treat MSW/RDF with thermochemical processes, gasification or pyrolysis. Research work in general is not covered, only R and D efforts that have led to substantial testing in pilot scale or demonstration. For further details, especially related to ongoing R and D, readers are referred to other recent reviews. The authors' view is that gasification of RDF with appropriate gas cleaning can play an important role in the future, for environmentally acceptable and efficient energy production. A prerequisite is that some of the major mistakes can be avoided, such as: (1) too rapid scale-up without experimental base, (2) unsuitable pretreatment of MSW to RDF and poor integration with material recycling, and (3) too limited gas/flue gas cleaning.

  8. INTELLECTUAL PROPERTY IN THE TWENTY-FIRST CENTURY: WILL THE DEVELOPING COUNTRIES LEAD OR FOLLOW?

    Science.gov (United States)

    Reichman, Jerome H.

    2010-01-01

    Developing countries, particularly the BRIC countries of Brazil, Russia, India, and China, should accommodate their national systems of innovation to the worldwide intellectual property (IP) regime emerging after the adoption of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) in a way that maximizes global economic welfare in the foreseeable future. As many developed countries’ experience demonstrates, badly configured, over-protectionist IP regimes stifle innovation by making inputs to future innovation too costly and too cumbersome to sustain over time. More carefully considered IP regimes, however, are an important way to protect innovative small- and medium-sized firms from predatory, larger competitors. The challenge is for emerging economies to capture the benefits of IP without importing the serious problems that developed countries have themselves failed to solve. Emerging economies can attain this balance by pursuing a policy of counter-harmonization in which they take advantage of existing exemptions in international agreements governing IP to establish regional, local, and international practices that promote more innovative, flexible uses of IP. Such practices include a research exemption for experimental uses of IP, government imposed nonexclusive licensing, anti-blocking provisions, an essential facilities doctrine, and compulsory licenses. Additional tools include an ex ante regime of compensatory liability rules for small scale innovation and sensible exceptions, particularly for science as well as general fair use provisions, to the exclusive rights of domestic copyright laws. Emerging economies will have to overcome strong economic pressure to accept more restrictive IP regimes as part of free trade agreements as well as a lack of technical expertise and internal government coordination. However, emerging economies have already accrued enough experience to be aware of the strengths and weaknesses of various IP

  9. [Twenty years of bioethics in Mexico: development and perspectives of the National Bioethics Commission].

    Science.gov (United States)

    Ruiz de Chávez-Guerrero, Manuel Hugo

    2014-01-01

    Bioethics in Mexico has a history that reveals the vision and ethical commitment of iconic characters in the fields of health sciences and humanities, leading to the creation of the National Bioethics Commission responsible for promoting a bioethics culture in Mexico. Its development and consolidation from the higher perspective of humanism had the aim to preserve health, life and its environment, while at the same time the bases of ethics and professional practice from different perspectives have been the building blocks of medical practice.

  10. Fragility of Success: Repositioning Mauritian Development in the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    Greig, Alastair

    2011-11-01

    Full Text Available Mauritius is often considered a ‘success story’ to be read for salutary purposes by other small island developing states (SIDS. While it does share broadly similar attributes with many other SIDS, and acts in unison with other SIDS in international fora, local histories, cultures, geography and location invariably lead to significant differences in developmental trajectories. This paper presents an assessment of Mauritian history in order to explore the contemporary threats and opportunities that face the island in its contemporary quest to transform the island into Maurice Ȋle Durable. Rather than offering Mauritius as a guide to other SIDS, it presents a useful case study of the tension between establishing social equity and carving out a functional role within the global economy.

  11. Landmarks in the historical development of twenty first century food processing technologies.

    Science.gov (United States)

    Misra, N N; Koubaa, Mohamed; Roohinejad, Shahin; Juliano, Pablo; Alpas, Hami; Inácio, Rita S; Saraiva, Jorge A; Barba, Francisco J

    2017-07-01

    Over a course of centuries, various food processing technologies have been explored and implemented to provide safe, fresher-tasting and nutritive food products. Among these technologies, application of emerging food processes (e.g., cold plasma, pressurized fluids, pulsed electric fields, ohmic heating, radiofrequency electric fields, ultrasonics and megasonics, high hydrostatic pressure, high pressure homogenization, hyperbaric storage, and negative pressure cavitation extraction) have attracted much attention in the past decades. This is because, compared to their conventional counterparts, novel food processes allow a significant reduction in the overall processing times with savings in energy consumption, while ensuring food safety, and ample benefits for the industry. Noteworthily, industry and university teams have made extensive efforts for the development of novel technologies, with sound scientific knowledge of their effects on different food materials. The main objective of this review is to provide a historical account of the extensive efforts and inventions in the field of emerging food processing technologies since their inception to present day. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Classroom modules for nanotechnology undergraduate education: development, implementation and evaluation

    Science.gov (United States)

    Shabani, R.; Massi, L.; Zhai, L.; Seal, S.; Cho, H. J.

    2011-05-01

    In order to address the challenges and restrictions given by a traditional classroom lecture environment, the top-down and bottom-up nanotechnology teaching modules were developed, implemented and evaluated. Then based on the hypothesis that instructors could further develop students' interest in this emerging area through the introduction of the teaching modules and a career module, an early stage evaluation of the effectiveness of the modules in selected engineering courses was conducted. The data suggested that adoption of modular lectures in regular engineering courses influenced attitude towards nanotechnology - overall, the teaching modules did a better job of piquing student's interest (albeit in the short term) in the subject, but there were also positive gains in interest in nanotechnology as a career. There was some evidence that the hands-on demonstration teaching modules with visual elements and the career module were more effective than traditional lecture presentations in the classroom.

  13. Measuring Twenty-First Century Skills: Development and Validation of a Scale for In-Service and Pre-Service Teachers

    Science.gov (United States)

    Jia, Yueming; Oh, Youn Joo; Sibuma, Bernadette; LaBanca, Frank; Lorentson, Mhora

    2016-01-01

    A self-report scale that measures teachers' confidence in teaching students about twenty-first century skills was developed and validated with pre-service and in-service teachers. First, 16 items were created to measure teaching confidence in six areas: information literacy, collaboration, communication, innovation and creativity, problem solving,…

  14. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  15. Software development for bistable module of SMART plant protection system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. H.; Park, H. S.; Jeo, C. W. [Samchang Enterprise Co., Ltd., Taejon (Korea, Republic of); Lee, J. G.; Park, H. Y.; Koo, I. S. [KAERI, Taejon (Korea, Republic of)

    2003-10-01

    Digitalized PPS(Plant Protection System) is going on development for SMART. The PPS consists of two different types of CPUs and DSP boards for the each functional processor modules of PPS. Software for the system has been progressed with teamwork of CASE TOOL to develop the reliable software. In this paper, we propose the software development method and show the examples for Bistable module through the functional analysis and the development of Structure Chart and M-Spec.

  16. VLSI 'smart' I/O module development

    Science.gov (United States)

    Kirk, Dan

    The developmental history, design, and operation of the MIL-STD-1553A/B discrete and serial module (DSM) for the U.S. Navy AN/AYK-14(V) avionics computer are described and illustrated with diagrams. The ongoing preplanned product improvement for the AN/AYK-14(V) includes five dual-redundant MIL-STD-1553 channels based on DSMs. The DSM is a front-end processor for transferring data to and from a common memory, sharing memory with a host processor to provide improved 'smart' input/output performance. Each DSM comprises three hardware sections: three VLSI-6000 semicustomized CMOS arrays, memory units to support the arrays, and buffers and resynchronization circuits. The DSM hardware module design, VLSI-6000 design tools, controlware and test software, and checkout procedures (using a hardware simulator) are characterized in detail.

  17. Development of 10kW SOFC module

    Energy Technology Data Exchange (ETDEWEB)

    Hisatome, N.; Nagata, K. [Mitsubishi Heavy Industries, Ltd., Nagasaki (Japan); Kakigami, S. [Electric Power Development Co., Inc., Tokyo (Japan)] [and others

    1996-12-31

    Mitsubishi Heavy industries, Ltd. (MHI) has been developing tubular type Solid Oxide Fuel Cells (SOFC) since 1984. A 1 kW module of SOFC has been continuously operated for 3,000 hours with 2 scheduled thermal cycles at Electric Power Development Co., Inc. (EPDC) Wakamatsu Power Station in 1993. We have obtained of 34% (HHV as H{sub 2}) module efficiency and deterioration rate of 2% Per 1,000 hours in this field test. As for next step, we have developed 10 kW module in 1995. The 10 kW module has been operated for 5,000 hours continuously. This module does not need heating support to maintain the operation temperature, and the module efficiency was 34% (HHV as H{sub 2}). On the other hand, we have started developing the technology of pressurized SOFC. In 1996, pressurized MW module has been tested at MHI Nagasaki Shipyard & Machinery, Works. We are now planning the development of pressurized 10 kW module.

  18. Modulational development of nonlinear gravity-wave groups

    Science.gov (United States)

    Chereskin, T. K.; Mollo-Christensen, E.

    1985-01-01

    Observations of the development of nonlinear surface gravity-wave groups are presented, and the amplitude and phase modulations are calculated using Hilbert-transform techniques. With increasing propagation distance and wave steepness, the phase modulation develops local phase reversals whose locations correspond to amplitude minima or nodes. The concomitant frequency modulation develops jumps or discontinuities. The observations are compared with recent similar results for wavetrains. The observations are modelled numerically using the cubic nonlinear Schroedinger equation. The motivation is twofold: to examine quantitatively the evolution of phase as well as amplitude modulation, and to test the inviscid predictions for the asymptotic behavior of groups versus long-time observations. Although dissipation rules out the recurrence, there is a long-time coherence of the groups. The phase modulation is found to distinguish between dispersive and soliton behavior.

  19. From Linear Lecture to Interactive Multimedia Module: A Developer's Perspective.

    Science.gov (United States)

    Leeder, Dawn

    2000-01-01

    Discusses the development of interactive multimedia learning modules and describes the decisions and processes involved in transforming a traditional lecture in medical sociology into an interactive online learning module at the University of Cambridge (United Kingdom). Considers method of delivery, including the World Wide Web; media choices; and…

  20. Development and deployment of innovative distance education modules

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Wen-Hsing [Nuclear Science Centre, Texas A and M University, 1095 Nuclear Science RD, College Station, Texas 77843 (United States); Reece, W. Daniel [Nuclear Engineering Department, Texas A and M University, College Station, Texas 77843 (United States)

    2010-07-01

    The potential of distance education/learning to deliver knowledge to learners outside the classroom is increasing dramatically as the technologies evolve. Through the past seven years at Texas A and M University Nuclear Science Centre, media-rich distance learning modules of lectures has been developed using the cutting edge technology available. Accordingly, the framework of modularised distance education modules has been established as well. Each module, closed caption enabled, consists of short interactive videos with animations and quizzes embedded. Those individual videos can be regrouped to form a new module depending on the contents of the lecture. The framework of this system was explained and the procedures of creating those modules were detailed. Different deployment methodologies of those modules were also discussed. (authors)

  1. Low Cost Fiber Optic Module Development Program.

    Science.gov (United States)

    1979-12-01

    159.04 G&A @28% 24.89 28.63 SUBTOTAL 163.19 187.67 PROFIT @12% 19.58 22.52 TOTAL $ 182.77 $ 210.19 2 manufacturing aids should be performed with the...Characteristics Parameter Test Condition Min.lTypical Max. Unit High-level input voltage, VIH --- 2.0 2.4 --- V Low-level input voltage, VIL --- 0.4 0.8 V...retaining plate, and ceramic substrate temperatures were measured with the module under different operating modes at 250C and 950C ambient temperature. A

  2. Development of selective androgen receptor modulators (SARMs).

    Science.gov (United States)

    Narayanan, Ramesh; Coss, Christopher C; Dalton, James T

    2017-06-15

    The Androgen Receptor (AR), a member of the steroid hormone receptor family, plays important roles in the physiology and pathology of diverse tissues. AR ligands, which include circulating testosterone and locally synthesized dihydrotestosterone, bind to and activate the AR to elicit their effects. Ubiquitous expression of the AR, metabolism and cross reactivity with other receptors limit broad therapeutic utilization of steroidal androgens. However, the discovery of selective androgen receptor modulators (SARMs) and other tissue-selective nuclear hormone receptor modulators that activate their cognate receptors in a tissue-selective manner provides an opportunity to promote the beneficial effects of androgens and other hormones in target tissues with greatly reduced unwanted side-effects. In the last two decades, significant resources have been dedicated to the discovery and biological characterization of SARMs in an effort to harness the untapped potential of the AR. SARMs have been proposed as treatments of choice for various diseases, including muscle-wasting, breast cancer, and osteoporosis. This review provides insight into the evolution of SARMs from proof-of-concept agents to the cusp of therapeutic use in less than two decades, while covering contemporary views of their mechanisms of action and therapeutic benefits. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. The development of polymer membranes and modules for air separation

    Science.gov (United States)

    Vinogradov, N. E.; Kagramanov, G. G.

    2016-09-01

    Technology of hollow fiber membrane and modules for air separation was developed. Hollow fibers from the polyphenylene oxide (PPO) having a diameter of 500 μm were obtained. The permeability of the fibers by oxygen was up to 250 Ba, while the separation factor by O2/N2 was 4.3. The membrane module has been made by using these fibers and tested for permeability of individual gases.

  4. Light weight and compact TR Module development

    NARCIS (Netherlands)

    Grooters, R.; Heijningen, M.; Vliet, F.E. van

    2011-01-01

    TNO has a long history in design and development of dedicated RF MMICs to be used in all kind of applications and for different popular frequency bands, especially related to RADAR applications. These designs make use of the leading available MMIC processes, and commercialisation of some of these pr

  5. Solar kinetics` photovoltaic concentrator module and tracker development

    Energy Technology Data Exchange (ETDEWEB)

    White, D.L.; Howell, B. [Solar Kinetics, Inc., Dallas, TX (United States)

    1995-11-01

    Solar Kinetics, Inc., has been developing a point-focus concentrating photovoltaic module and tracker system under contract to Sandia National Laboratories. The primary focus of the contract was to achieve a module design that was manufacturable and passed Sandia`s environmental testing. Nine modules of two variations were assembled, tested, and characterized in Phase 1, and results of these tests were promising, with module efficiency approaching the theoretical limit achievable with the components used. The module efficiency was 11.9% at a solar irradiance of 850 W/m{sup 2} and an extrapolated cell temperature of 25{degrees}C. Improvements in module performance are anticipated as cell efficiencies meet their expectations. A 2-kW tracker and controller accommodating 20 modules was designed, built, installed, and operated at Solar Kinetics` test site. The drive used many commercially available components in an innovative arrangement to reduce cost and increase reliability. Backlash and bearing play were controlled by use of preloaded, low slip-stick, synthetic slide bearings. The controller design used a standard industrial programmable logic controller to perform ephemeris calculations, operate the actuators, and monitor encoders.

  6. Classroom Modules for Nanotechnology Undergraduate Education: Development, Implementation and Evaluation

    Science.gov (United States)

    Shabani, R.; Massi, L.; Zhai, L.; Seal, S.; Cho, H. J.

    2011-01-01

    In order to address the challenges and restrictions given by a traditional classroom lecture environment, the top-down and bottom-up nanotechnology teaching modules were developed, implemented and evaluated. Then based on the hypothesis that instructors could further develop students' interest in this emerging area through the introduction of the…

  7. Developing an On-Line Interactive Health Psychology Module

    Science.gov (United States)

    Upton, Dominic; Cooper, Carol

    2006-01-01

    On-line teaching material in health psychology was developed which ensured a range of students could access appropriate material for their course and level of study. This material has been developed around the concept of smaller "content chunks" which can be combined into whole units of learning (topics), and ultimately, a module. On the basis of…

  8. Development and Testing of Shingle-type Solar Cell Modules

    Science.gov (United States)

    Shepard, N. F., Jr.

    1979-01-01

    The design, development, fabrication and testing of a shingle-type terrestrial solar cell module which produces 98 watts/sq m of exposed module area at 1 kW/sq m insolation and 61 C are reported. These modules make it possible to easily incorporate photovoltaic power generation into the sloping roofs of residential or commercial buildings by simply nailing the modules to the plywood roof sheathing. This design consists of nineteen series-connected 53 mm diameter solar cells arranged in a closely packed hexagon configuration. These cells are individually bonded to the embossed surface of a 3 mm thick thermally tempered hexagon-shaped piece of glass. Polyvinyl butyral is used as the laminating adhesive.

  9. Cassegrainian concentrator solar array exploratory development module

    Science.gov (United States)

    Patterson, R. E.; Crabtree, W. L.

    1982-01-01

    A miniaturized Cassegrainian concentrator solar array concept is under development to reduce the cost of multi-kW spacecraft solar arrays. A primary parabolic reflector directs incoming solar energy to a secondary, centrally mounted inverted hyperbolic reflector and down onto a solar cell mounted on an Mo heat spreader on a 0.25 mm thick Al heat fin. Each unit is 12.7 mm thick, which makes the concentrator assembly roughly as thick as a conventional panel. The output is 100 W/sq and 20 W/kg, considering 20% efficient Si cells at 100 suns. A tertiary light catcher is mounted around the cell to ameliorate optic errors. The primary reflector is electroformed Ni with protective and reflective coatings. The cells have back surface reflectors and a SiO antireflective coating. An optical efficiency of 80% is projected, and GaAs cells are being considered in an attempt to raise cell efficiencies to over 30%.

  10. Twenty Years and Counting: An Examination of the Development of Equity and Inclusive Education Policy in Ontario (1990-2010)

    Science.gov (United States)

    Segeren, Allison; Kutsyuruba, Benjamin

    2012-01-01

    In response to the oft-cited inadequacies of the policies and pedagogies of multicultural education, the Ontario Ministry of Education mandated that school boards develop equity and inclusive education policies, as specified in Policy/Program Memorandum No. 119 [2009 version]: "Developing and Implementing Equity and Inclusive Education…

  11. Human development I: twenty fundamental problems of biology, medicine, and neuro-psychology related to biological information.

    Science.gov (United States)

    Hermansen, Tyge Dahl; Ventegodt, Søren; Rald, Erik; Clausen, Birgitte; Nielsen, Maj Lyck; Merrick, Joav

    2006-07-06

    In a new series of papers, we address a number of unsolved problems in biology today. First of all, the unsolved enigma concerning how the differentiation from a single zygote to an adult individual happens has been object for severe research for decades. By uncovering a new holistic biological paradigm that introduces an energetic-informational interpretation of reality as a new way to experience biology, these papers will try to solve the problems connected with the events of biological ontogenesis involving a fractal hierarchy, from a single cell to the function of the human brain. The problems discussed are interpreted within the frames of a universe of roomy fractal structures containing energetic patterns that are able to deliver biological information. We think biological organization is guided by energetic changes on the level of quantum mechanics, interacting with the intention that again guides the energetic conformation of the fractal structures to gain disorders or healthiness. Furthermore, we introduce two new concepts: "metamorphous top down" evolution and "adult human metamorphosis". The first is a new evolutionary theory involving metamorphosis as a main concept of evolution. The last is tightly linked to the evolutionary principle and explains how human self-recovery is governed. Other subjects of special interest that we shall look deeper into are the immunological self-nonself discrimination, the structure and function of the human brain, the etiology and salutogenesis of mental and somatic diseases, and the structure of the consciousness of a human being. We shall criticize Szentagothai's model for the modulated structure of the human cerebral cortex and Jerne's theory of the immunological regulatory anti-idiotypic network.

  12. Human development I: Twenty Fundamental Problems of Biology, Medicine, and Neuro-Psychology Related to Biological Information

    Directory of Open Access Journals (Sweden)

    Tyge Dahl Hermansen

    2006-01-01

    Full Text Available In a new series of papers, we address a number of unsolved problems in biology today. First of all, the unsolved enigma concerning how the differentiation from a single zygote to an adult individual happens has been object for severe research for decades. By uncovering a new holistic biological paradigm that introduces an energetic-informational interpretation of reality as a new way to experience biology, these papers will try to solve the problems connected with the events of biological ontogenesis involving a fractal hierarchy, from a single cell to the function of the human brain. The problems discussed are interpreted within the frames of a universe of roomy fractal structures containing energetic patterns that are able to deliver biological information. We think biological organization is guided by energetic changes on the level of quantum mechanics, interacting with the intention that again guides the energetic conformation of the fractal structures to gain disorders or healthiness. Furthermore, we introduce two new concepts: “metamorphous top down” evolution and “adult human metamorphosis”. The first is a new evolutionary theory involving metamorphosis as a main concept of evolution. The last is tightly linked to the evolutionary principle and explains how human self-recovery is governed. Other subjects of special interest that we shall look deeper into are the immunological self-nonself discrimination, the structure and function of the human brain, the etiology and salutogenesis of mental and somatic diseases, and the structure of the consciousness of a human being. We shall criticize Szentagothai’s model for the modulated structure of the human cerebral cortex and Jerne’s theory of the immunological regulatory anti-idiotypic network.

  13. Development of an AC Module System: Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Suparna Kadam; Miles Russell

    2012-06-15

    The GreenRay Inc. program focused on simplifying solar electricity and making it affordable and accessible to the mainstream population. This was accomplished by integrating a solar module, micro-inverter, mounting and monitoring into a reliable, 'plug and play' AC system for residential rooftops, offering the following advantages: (1) Reduced Cost: Reduction in installation labor with fewer components, faster mounting, faster wiring. (2) Maximized Energy Production: Each AC Module operates at its maximum, reducing overall losses from shading, mismatch, or module downtime. (3) Increased Safety. Electrical and fire safety experts agree that AC Modules have significant benefits, with no energized wiring or live connections during installation, maintenance or emergency conditions. (4) Simplified PV for a Broader Group of Installers. Dramatic simplification of design and installation of a solar power system, enabling faster and more efficient delivery of the product into the market through well-established, mainstream channels. This makes solar more accessible to the public. (5) Broadened the Rooftop Market: AC Modules enable solar for many homes that have shading, split roofs, or obstructions. In addition, due to the smaller building block size of 200W vs. 1000W, homeowners with budget limitations can start small and add to their systems over time. Through this DOE program GreenRay developed the all-in-one AC Module system with an integrated PV Module and microinverter, custom residential mounting and performance monitoring. Development efforts took the product from its initial concept, through prototypes, to a commercial product sold and deployed in the residential market. This pilot deployment has demonstrated the technical effectiveness of the AC Module system in meeting the needs and solving the problems of the residential market. While more expensive than the traditional central inverter systems at the pilot scale, the economics of AC Modules become

  14. Development of an AC Module System: Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Suparna Kadam; Miles Russell

    2012-06-15

    The GreenRay Inc. program focused on simplifying solar electricity and making it affordable and accessible to the mainstream population. This was accomplished by integrating a solar module, micro-inverter, mounting and monitoring into a reliable, 'plug and play' AC system for residential rooftops, offering the following advantages: (1) Reduced Cost: Reduction in installation labor with fewer components, faster mounting, faster wiring. (2) Maximized Energy Production: Each AC Module operates at its maximum, reducing overall losses from shading, mismatch, or module downtime. (3) Increased Safety. Electrical and fire safety experts agree that AC Modules have significant benefits, with no energized wiring or live connections during installation, maintenance or emergency conditions. (4) Simplified PV for a Broader Group of Installers. Dramatic simplification of design and installation of a solar power system, enabling faster and more efficient delivery of the product into the market through well-established, mainstream channels. This makes solar more accessible to the public. (5) Broadened the Rooftop Market: AC Modules enable solar for many homes that have shading, split roofs, or obstructions. In addition, due to the smaller building block size of 200W vs. 1000W, homeowners with budget limitations can start small and add to their systems over time. Through this DOE program GreenRay developed the all-in-one AC Module system with an integrated PV Module and microinverter, custom residential mounting and performance monitoring. Development efforts took the product from its initial concept, through prototypes, to a commercial product sold and deployed in the residential market. This pilot deployment has demonstrated the technical effectiveness of the AC Module system in meeting the needs and solving the problems of the residential market. While more expensive than the traditional central inverter systems at the pilot scale, the economics of AC Modules become

  15. Oilheat research agenda: A ten year blueprint for residential oilheat research and development in the Twenty-First Century

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, R.J. [Brookhaven National Lab., Upton, NY (United States); Batey, J.E. [Energy Research Center (United States)

    1996-05-01

    This report summarizes a joint research agenda planned for the US Department of Energy and the National Oilheat Research Alliance (NORA) under a cooperative effort between the Federal government and the private sector industries involved in oilheat marketing. The objective of the oilheat research program is to develop the technical basis for improved equipment designs and operating strategies based on an enhanced understanding of oil-burning fundamentals, heat transfer, and associated environmental factors. The program will continue to provide the oil-fueled heating equipment industry with the basis for developing a new, modern generation of equipment and provide the oil marketers, equipment installers, and consumers with improved knowledge of how best to install, maintain, and operate such equipment for maximum performance and minimum fuel use and environmental impact.

  16. The development of an exemplar e-module for the continuing professional development of European dentists

    NARCIS (Netherlands)

    Kossioni, A.E.; Kavadella, A.; Tzoutzas, I.; Bakas, A.; Tsiklakis, K.; Bailey, S.; Bullock, A.; Cowpe, J.; Barnes, E.; Thomas, H.; Thomas, R.; Karaharju-Suvanto, T.; Suomalainen, K.; Kersten, H.; Povel, E.; Giles, M.; Walmsley, D.; Soboleva, U.; Liepa, A.; Akota, I.

    2013-01-01

    Aim To present the development of an exemplar e-module for dental continuing professional development (CPD) provided by dental schools and other dental educational providers. Materials and methods The exemplar e-module covered the topic of ‘Sterilisation and cross-infection control in the dental pra

  17. Cooperation between China and Germany for twenty years as well as development of international welding training and qualification in China

    Institute of Scientific and Technical Information of China (English)

    Xie Yinglong; Dai Wanfu; Piao Dongguang

    2005-01-01

    Chinese Welding Training and Qualification Committee (CANB) was awarded the authorisation of ⅡW in 2000,and has issued nearly 2000 ⅡW diplomas by the end of 2004. Since Harbin Welding Training Institute ( WTI Harbin) was founded based on Sino-German cooperation in 1984, it has trained all kinds of welding personnel 20 000 and it made important contribution to the up-to-date system introduction of international welding training to China. The common questions in Germany foreign aid programs are: when German experts were on site, the project was on the operation; when he/they left,only memory was left. The outstanding achievements of Harbin Welding Training Institute tell us: when German experts were away, the cooperation program is not only run normally, but also gets persistent development, it is the successful model among the cooperation projects between China and Germany.

  18. Development and evaluation of global child health educational modules.

    Science.gov (United States)

    Audcent, Tobey A; Macdonnell, Heather M; Moreau, Katherine A; Hawkes, Michael; Sauve, Laura J; Crockett, Maryanne; Fisher, Julie A; Goldfarb, David M; Hunter, Andrea J; McCarthy, Anne E; Pernica, Jeffrey M; Liu, Joanne; Luong, Tinh-Nhan; Sandhu, Amonpreet K; Rashed, Selim; Levy, Arielle; Brenner, Jennifer L

    2013-12-01

    To determine if a standardized global child health (GCH) modular course for pediatric residents leads to satisfaction, learning, and behavior change. Four 1-hour interactive GCH modules were developed addressing priority GCH topics. "Site champions" from 4 Canadian institutions delivered modules to pediatric residents from their respective programs during academic half-days. A pre-post, mixed methods evaluation incorporated satisfaction surveys, multiple-choice knowledge tests, and focus group discussions involving residents and satisfaction surveys from program directors. A total of 125 trainees participated in ≥1 module. Satisfaction levels were high. Focus group participants reported high satisfaction with the concepts taught and the dynamic, participatory approach used, which incorporated multimedia resources. Mean scores on knowledge tests increased significantly postintervention for 3 of the 4 modules (P < .001), and residents cited increases in their practical knowledge, global health awareness, and motivation to learn about global health. Program directors unanimously agreed that the modules were relevant, interesting, and could be integrated within existing formal training time. A relatively short, participatory, foundational GCH modular curriculum facilitated knowledge acquisition and attitude change. It could be scaled up and serve as a model for other standardized North American curricula.

  19. Detector module development for the CBM Silicon Tracking System

    Energy Technology Data Exchange (ETDEWEB)

    Lymanets, Anton [Physikalisches Institut, Universitaet Tuebingen (Germany); Collaboration: CBM-Collaboration

    2013-07-01

    The central detector of the CBM experiment at FAIR, the Silicon Tracking System (STS), is being designed to reconstruct hundreds of charged particles produced at rates up to 10 MHz in interactions of ion beams of up to 45 AGeV projectile energies with nuclear targets. The building block of the tracking system is a module suitable for a low-mass detector construction. In a module, the basic functional unit of the STS, radiation tolerant microstrip sensors are read out through low-mass multi-line cables with self-triggering front-end electronics located at the periphery of the system. Light-weight carbon fibre support structures will carry 10 of such modules and build up the STS stations. In the presentation, the concept of the detector module construction is presented. Quality assurance tests under development for the module components (double-sided silicon microstrip sensors, stacked polyimide microcables, front-end ASICs and boards) and the assembled structures are discussed.

  20. DEVELOPMENT OF LOAN MODULE USING BUSINESS RULES ENGINE

    Directory of Open Access Journals (Sweden)

    Sachin Chaware

    2015-10-01

    Full Text Available Banking loan module is a runtime business application. It is the automatic processing of all the loans, due to which the loan form can be filled from anywhere and the bank person approves loan within short span of time. There is very big crowd to fill the loan form manually which is very tiresome job. Also the manual process is very lengthy process which requires 3 days for approval of loan. Our customers will having their loan applications approved within 60 minutes of lodging the application instead of 3 days as per the paper-centric solution we were persisting with. This paper consists of method of development of dynamic loan module system which includes the loan origination process, loan form filling process and loan verification process. The method is developed by using the RETE pattern matching algorithm. Due to which the loan module system becomes very fast and work effective. In addition to this loan module system, we have also developed the CIBIL score generating system for the approved loan applications and determination of rupee dollar rate and calculation of rate of interest of loans. Due to which the manager originates the roi of loans that also helps the manager to stabilize the India’s economy and prevents itself from recession and other economic falls.

  1. High School Students' Perceptions of the Effects of International Science Olympiad on Their STEM Career Aspirations and Twenty-First Century Skill Development

    Science.gov (United States)

    Sahin, Alpaslan; Gulacar, Ozcan; Stuessy, Carol

    2015-12-01

    Social cognitive theory guided the design of a survey to investigate high school students' perceptions of factors affecting their career contemplations and beliefs regarding the influence of their participation in the international Science Olympiad on their subject interests and twenty-first century skills. In addition, gender differences in students' choice of competition category were studied. Mixed methods analysis of survey returns from 172 Olympiad participants from 31 countries showed that students' career aspirations were affected most by their teachers, personal interests, and parents, respectively. Students also indicated that they believed that their participation in the Olympiad reinforced their plan to choose a science, technology, engineering, and mathematics (STEM) major at college and assisted them in developing and improving their twenty-first century skills. Furthermore, female students' responses indicated that their project choices were less likely to be in the engineering category and more likely to be in the environment or energy categories. Findings are discussed in the light of increasing the awareness of the role and importance of Science Olympiads in STEM career choice and finding ways to attract more female students into engineering careers.

  2. Development of multicriteria modules for environmental valu- ation in GRASS GIS

    Directory of Open Access Journals (Sweden)

    G. Massei

    2014-01-01

    Full Text Available Dealing with spatial decision problems means very often to face a GIS and a multi-criteria decision analysis based problem at the same time. GIS and Multi-criteria Decision Analysis are two well defined research areas, but both can benefit one from each other. In the last twenty years several researches have paid attention to MCDA-GIS integration and to the development of Spatial Decision Support Systems (SDSS, but few papers presented examples of perfect integration. Also in case of perfect integration, they often integrate within GIS only one multicriteria model. Our application is a better contribution in this way. We developed four GRASS modules that permit to implement four different MCDA methods: the Regime, the FUZZY, the ELECTRE and the Dominance-based Rough Set Approach. One of the main advantages of our application over the previous ones is the possibility of a future development in an open-source context. The paper presents an application of the Regime, Electre and Fuzzy modules.

  3. Development of modulators against degenerative aging using radiation fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Jo, S. K.; Park, H. R.; Jang, B. S.; Roh, C. H.; Eom, H. S.; Choi, N. H.; Seol, M. A.; Kim, S. H.; Choi, H. M.; Park, M. K.; Shin, H. J.; Ryu, D. K.; Oh, W. J.; Kim, S. H; Yee, S. T.

    2012-04-15

    1. Objectives Establishment of modelling of degenerative aging using radiation technology Development of aging modulators using radiation degenerative aging model 2. Project results Establishment of the modeling of degenerative aging using radiation technology - The systematic study on the comparison of radiation-induced degeneration and natural aging process in animals and cells confirmed the biological similarity between these two degeneration models - The effective biomarkers were selected for the modelling of degenerative aging using radiation (10 biomarkers for immune/hematopoiesis, 1 for oxidative stress, 6 for molecular signaling, 3 for lipid metabolism) - The optimal irradiation condition was established for the modelling of degerative aging (total 5Gy with fractionation by over 10 times, lapse of over 4 months) - The molecular mechanisms of radiation-induced degeneration were studied including chronic inflammation (lung), inflammation-related lipid metabolism disturbance, mitochondria biogenesis and dynamics - The radiation degenerative model was evaluated with previously known natural substances (resveratrol, EGCG, etc) Development of aging modulators using radiation degenerative aging model - After the screening of about 800 natural herb extracts, 5 effective substances were selected for aging modulation. - 3 candidate compositions were selected from 20 compositions made from effective substances by in vitro evaluation (WAH2, WAH6, WAH7) - 1 composition (WAH6) was selected as the best aging modulator by in vivo evaluation in radiation-induced aging models and degenerative disease models. 3. Expected benefits and plan of application The modelling of degenerative aging using radiation can facilitate the aging research by providing the useful cell/animal models for aging research A large economic benefits are expected by the commercialization of developed aging modulators (over 10 billion KW in 2015.

  4. Development of an educational module on provider self-care.

    Science.gov (United States)

    Meadors, Patrick; Lamson, Angela; Sira, Natalia

    2010-01-01

    Intensive care providers who care for traumatized populations often face multiple traumas for extended periods and are vulnerable to developing lasting symptoms of compassion fatigue and secondary traumatization. Symptoms are often not recognizable until compassion fatigue or secondary traumatization negatively affects the providers' ability to care for their patients. More attention needs to be given to the care of the provider to ensure high-quality patient care, decrease turnover in the profession, and increase productivity. This article provides a framework for the development of an educational module for healthcare providers' self-care. This educational module created the opportunity to share with providers (a) how to explore their own professional experience; (b) how to recognize the different symptoms of compassion fatigue, primary traumatization, and secondary traumatization; (c) factors related to grief reactions; and (d) personal and professional strategies to decrease compassion fatigue and secondary traumatization.

  5. Development of a high density pixel multichip module at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, G. [and others

    2001-03-08

    At Fermilab, both pixel detector multichip module and sensor hybridization are being developed for the BTeV experiment. The BTeV pixel detector is based on a design relying on a hybrid approach. With this approach, the readout chip and the sensor array are developed separately and the detector is constructed by flip-chip mating the two together. This method offers maximum flexibility in the development process, choice of fabrication technologies, and the choice of sensor material. This paper presents strategies to handle the required data rate and performance results of the first prototype and detector hybridization.

  6. Design/Development of Spacecraft and Module Crew Compartments

    Science.gov (United States)

    Goodman, Jerry R.

    2010-01-01

    This slide presentation reviews the design and development of crew compartments for spacecraft and for modules. The Crew Compartment or Crew Station is defined as the spacecraft interior and all other areas the crewman interfaces inside the cabin, or may potentially interface.It uses examples from all of the human rated spacecraft. It includes information about the process, significant drivers for the design, habitability, definitions of models, mockups, prototypes and trainers, including pictures of each stage in the development from Apollo, pictures of the space shuttle trainers, and International Space Station trainers. It further reviews the size and shape of the Space Shuttle orbiter crew compartment, and the Apollo command module and the lunar module. It also has a chart which reviews the International Space Station (ISS) internal volume by stage. The placement and use of windows is also discussed. Interestingly according to the table presented, the number 1 rated piece of equipment for recreation was viewing windows. The design of crew positions and restraints, crew translation aids and hardware restraints is shown with views of the restraints and handholds used from the Apollo program through the ISS.

  7. Recent advances in the development of selective androgen receptor modulators.

    Science.gov (United States)

    Zhang, Xuqing; Lanter, James C; Sui, Zhihua

    2009-09-01

    The androgens testosterone and its more potent tissue metabolite 5-alpha-dihydrotesterone regulate diverse physiological process involving both reproductive and non-reproductive functions. Most of the signaling effects of androgens are mediated through the androgen receptor (AR), a member of the nuclear receptor superfamily of transcription factors. The AR has been a target for drug development focused on the treatment of pathological conditions arising from abnormal androgen levels or altered target tissue responsiveness, the improvement of physical performance and the regulation of male fertility. The primary focus for drug design has been the synthesis of chemicals to regulate the transcriptional activity of AR based on the structural and functional properties of the ligands, with a recent preference for selectively anabolic non-steroidals. A new class of molecules targeting androgen receptors called selective androgen receptor modulators is being developed, analogous to the clinically successful and at present marketed selective estrogen receptor modulators. This article highlights and reviews research advances in this field that have been published in patent literature since 2003. The structural diversity of selective androgen receptor modulators has dramatically increased. Several compounds have emerged as clinical and preclinical candidates.

  8. Development of a Precise Polarization Modulator for UV Spectropolarimetry

    CERN Document Server

    Ishikawa, Shin-nosuke; Kano, Ryouhei; Bando, Takamasa; Ishikawa, Ryohko; Giono, Gabriel; Tsuneta, Saku; Nakayama, Satoshi; Tajima, Takao

    2015-01-01

    We developed a polarization modulation unit (PMU) to rotate a waveplate continuously in order to observe solar magnetic fields by spectropolarimetry. The non-uniformity of the PMU rotation may cause errors in the measurement of the degree of linear polarization (scale error) and its angle (crosstalk between Stokes-Q and -U), although it does not cause an artificial linear polarization signal (spurious polarization). We rotated a waveplate with the PMU to obtain a polarization modulation curve and estimated the scale error and crosstalk caused by the rotation non-uniformity. The estimated scale error and crosstalk were <0.01 % for both. This PMU will be used as a waveplate motor for the Chromospheric Lyman-Alpha SpectroPolarimeter (CLASP) rocket experiment. We confirmed that the PMU has the sufficient performance and function for CLASP.

  9. Development of a high resolution module for PET scanners

    Science.gov (United States)

    Stringhini, G.; Pizzichemi, M.; Ghezzi, A.; Stojkovic, A.; Tavernier, S.; Niknejad, T.; Varela, J.; Paganoni, M.; Auffray, E.

    2017-02-01

    Positron Emission Tomography (PET) scanners require high performances in term of spatial resolution and sensitivity to allow early detection of cancer masses. In small animal and organ dedicated PET scanners the Depth of Interaction (DOI) information has to be obtained to avoid parallax errors and to reconstruct high resolution images. In the whole body PET, the DOI information can be useful to correct for the time jitter of the optical photons along the main axis of the scintillator, improving the time performances. In this work we present the development of PET module designed to reach high performance as compared to the current scanners while keeping the complexity of the system reasonably low. The module presented is based on a 64 LYSO (Lutetium-yttrium oxyorthosilicate) crystals matrix and on a 4×4 MPPC (Multi Pixels Photon Counter) array as detector in a 4 to 1 coupling between the crystals and the detector and a single side readout. The lateral surfaces of the crystals are optically treated to be unpolished. The DOI and the energy resolution of the PET module are presented and a fast method to obtain the DOI calibration is discussed.

  10. 78 FR 14103 - Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) as...

    Science.gov (United States)

    2013-03-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) as Part... information regarding utilization alternatives for the planned Biotechnology Development Module (BDM)...

  11. Photovoltaic module certification/laboratory accreditation criteria development

    Energy Technology Data Exchange (ETDEWEB)

    Osterwald, C.R. [National Renewable Energy Lab., Golden, CO (United States); Hammond, R.L.; Wood, B.D.; Backus, C.E.; Sears, R.L. [Arizona State Univ., Tempe, AZ (United States); Zerlaut, G.A. [SC-International Inc., Phoenix, AZ (United States); D`Aiello, R.V. [RD Associates, Tempe, AZ (United States)

    1995-04-01

    This document provides an overview of the structure and function of typical product certification/laboratory accreditation programs. The overview is followed by a model program which could serve as the basis for a photovoltaic (PV) module certification/laboratory accreditation program. The model covers quality assurance procedures for the testing laboratory and manufacturer, third-party certification and labeling, and testing requirements (performance and reliability). A 30-member Criteria Development Committee was established to guide, review, and reach a majority consensus regarding criteria for a PV certification/laboratory accreditation program. Committee members represented PV manufacturers, end users, standards and codes organizations, and testing laboratories.

  12. Development of selective androgen receptor modulators and their therapeutic applications.

    Science.gov (United States)

    Chen, Fang; Rodan, Gideon A; Schmidt, Azi

    2002-01-01

    Androgens control a broad range of physiological functions. The androgen receptor (AR), a steroid receptor that mediates the diverse biological actions of androgens, is a ligand inducible transcription factor. Abnormalities in the androgen signaling system result in many disturbances ranging from changes in gender determination and sexual development to psychiatric and emotional disorders. Androgen replacement therapy can improve many clinical conditions including hypogonadism and osteoporosis, but is limited by the lack of efficacious and safe therapeutic agents with easy delivery options. Recent progress in the area of gene regulation by steroid receptors and by selective receptor modulators provides an opportunity to examine if selective androgen receptor modulators (SARMs) could address some of the problems associated with current androgen therapy. Since the composition of the transcriptional initiation complex recruited by liganded AR determines the specificity of gene regulation, synthetic ligands aimed at initiating transcription of tissue and promoter specific genes offers hope for developing better androgen therapy. Establishment of assays that predict synthetic ligand activity is critical for SARM development. Advancement in high throughput compound screening and gene fingerprinting technologies, such as microarrays and proteomics, will facilitate and accelerate identification of effective SARMs.

  13. Twenty lectures on thermodynamics

    CERN Document Server

    Buchdahl, H A

    2013-01-01

    Twenty Lectures on Thermodynamics is a course of lectures, parts of which the author has given various times over the last few years. The book gives the readers a bird's eye view of phenomenological and statistical thermodynamics. The book covers many areas in thermodynamics such as states and transition; adiabatic isolation; irreversibility; the first, second, third and Zeroth laws of thermodynamics; entropy and entropy law; the idea of the application of thermodynamics; pseudo-states; the quantum-static al canonical and grand canonical ensembles; and semi-classical gaseous systems. The text

  14. Recommendations for the development of e-modules for the continuing professional development of European dentists

    NARCIS (Netherlands)

    Kavadella, A.; Kossioni, A.E.; Tsiklakis, K.; Cowpe, J.; Bullock, A.; Barnes, E.; Bailey, S.; Thomas, H.; Thomas, R.; Karaharju-Suvanto, T.; Suomalainen, K.; Kersten, H.; Povel, E.; Giles, M.; Walmsley, D.; Soboleva, U.; Liepa, A.; Akota, I.

    2013-01-01

    Aims To provide evidence-based and peer-reviewed recommendations for the development of dental continuing professional development (CPD) learning e-modules. Methods The present recommendations are consensus recommendations of the DentCPD project team and were informed by a literature research, consu

  15. Status Report on NEAMS System Analysis Module Development

    Energy Technology Data Exchange (ETDEWEB)

    Hu, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Y. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-12-01

    Under the Reactor Product Line (RPL) of DOE-NE’s Nuclear Energy Advanced Modeling and Simulation (NEAMS) program, an advanced SFR System Analysis Module (SAM) is being developed at Argonne National Laboratory. The goal of the SAM development is to provide fast-running, improved-fidelity, whole-plant transient analyses capabilities. SAM utilizes an object-oriented application framework MOOSE), and its underlying meshing and finite-element library libMesh, as well as linear and non-linear solvers PETSc, to leverage modern advanced software environments and numerical methods. It also incorporates advances in physical and empirical models and seeks closure models based on information from high-fidelity simulations and experiments. This report provides an update on the SAM development, and summarizes the activities performed in FY15 and the first quarter of FY16. The tasks include: (1) implement the support of 2nd-order finite elements in SAM components for improved accuracy and computational efficiency; (2) improve the conjugate heat transfer modeling and develop pseudo 3-D full-core reactor heat transfer capabilities; (3) perform verification and validation tests as well as demonstration simulations; (4) develop the coupling requirements for SAS4A/SASSYS-1 and SAM integration.

  16. Twenty Years of KSHV

    Directory of Open Access Journals (Sweden)

    Yuan Chang

    2014-11-01

    Full Text Available Twenty years ago, Kaposi’s sarcoma (KS was the oncologic counterpart to Winston Churchill’s Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men—in fact, most KS patients were expected to die with the tumor rather than from it. Nevertheless, the course and manifestations of the disease varied widely in different clinical contexts. The puzzle of KS came to the forefront as a harbinger of the AIDS epidemic. The articles in this issue of Viruses recount progress made in understanding Kaposi’s sarcoma herpesvirus (KSHV since its initial description in 1994.

  17. Development of the educational Arduino module using the helium gas airship

    Science.gov (United States)

    Park, Se-Ho; Kim, Won-Hoe; Seo, Suk-Hyun

    2015-03-01

    Various educational Arduino modules with its simplicity have been developed since Arduino's release into the market. In this study, the helium gas airship was employed to make an Arduino module by applying Arduino Mini, Bluetooth and Android applications.

  18. Development of a Novel Non-Equilibrium Pulsed Plasma Ignition Module for High Altitude Turbojets Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An experimental research program focusing on design, development, and testing of a novel nonequilibrium plasma ignition module is proposed. The ignition module will...

  19. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Munoz Sanchez, Francisca Javiela; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is preparing for an extensive modification of its detectors in the course of the planned HL-LHC accelerator upgrade around 2025. The ATLAS upgrade includes the replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will be a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice, which is expected to take place in 2017. In this paper an overview of the ongoing R\\&D activities on modules and electronics for the ATLAS ITk is given including the main developments and achievements in silicon planar and 3D sensor technologies, readout and power challenges.

  20. The paf gene product modulates asexual development in Penicillium chrysogenum.

    Science.gov (United States)

    Hegedüs, Nikoletta; Sigl, Claudia; Zadra, Ivo; Pócsi, Istvan; Marx, Florentine

    2011-06-01

    Penicillium chrysogenum secretes a low molecular weight, cationic and cysteine-rich protein (PAF). It has growth inhibitory activity against the model organism Aspergillus nidulans and numerous zoo- and phytopathogenic fungi but shows only minimal conditional antifungal activity against the producing organism itself. In this study we provide evidence for an additional function of PAF which is distinct from the antifungal activity against putative ecologically concurrent microorganisms. Our data indicate that PAF enhances conidiation in P. chrysogenum by modulating the expression of brlA, the central regulatory gene for mitospore development. A paf deletion strain showed a significant impairment of mitospore formation which sustains our hypothesis that PAF plays an important role in balancing asexual differentiation in P. chrysogenum.

  1. Selective androgen receptor modulators in preclinical and clinical development

    Science.gov (United States)

    Narayanan, Ramesh; Mohler, Michael L.; Bohl, Casey E.; Miller, Duane D.; Dalton, James T.

    2008-01-01

    Androgen receptor (AR) plays a critical role in the function of several organs including primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable therapeutic target. Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produce less of a growth effect on prostate and other secondary sexual organs. SARMs provide therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, or end-stage renal disease, osteoporosis, frailty, and hypogonadism. This review summarizes the current standing of research and development of SARMs, crystallography of AR with SARMs, plausible mechanisms for their action and the potential therapeutic indications for this emerging class of drugs. PMID:19079612

  2. Guidelines for the Development of Computer-based Instruction Modules for Science and Engineering

    Directory of Open Access Journals (Sweden)

    Barry D. Davidson

    2003-10-01

    Full Text Available The design and development of a prototype computer-based instruction (CBI module is described. The module covers introductory structural analysis techniques and demonstrates the practicality of CBI for undergraduate engineering education. The module’s generic learning objectives are used to develop a set of guiding principles for CBI development. Choice of authoring software and the module architecture are presented, followed by the details of the user interface, logic, and screen layout. The module design and software development process outlined here are easily extended to computer-based tutorials that present problem solving methods for engineering, mathematics, and the natural sciences.

  3. The development of form two mathematics i-Think module (Mi-T2)

    Science.gov (United States)

    Yao, Foo Jing; Abdullah, Mohd Faizal Nizam Lee; Tien, Lee Tien

    2017-05-01

    This study aims to develop a training module i-THINK Mathematics Form Two (Mi-T2) to increase the higher-order thinking skills of students. The Mi-T2 training module was built based on the Sidek Module Development Model (2001). Constructivist learning theory, cognitive learning theory, i-THINK map and higher order thinking skills were the building blocks of the module development. In this study, researcher determined the validity and reliability of Mi-T2 module. The design being used in this study was descriptive study. To determine the needs of Mi-T2 module, questionnaires and literature review were used to collect data. When the need of the module was determined, the module was built and a pilot study was conducted to test the reliability of the Mi-T2 module. The pilot study was conducted at a secondary school in North Kinta, Perak. A Form Two class was selected to be the sample study through clustered random sampling. The pilot study was conducted for two months and one topic had been studied. The Mi-T2 module was evaluated by five expert panels to determine the content validity of the module. The instruments being used in the study were questionnaires about the necessity of the Mi-T2 module for guidance, questionnaires about the validity of the module and questionnaires concerning the reliability of the module. Statistical analysis was conducted to determine the validity and reliability coefficients of the Mi-T2 module. The content validity of Mi-T2 module was determined by Cohen's Kappa's (1968) agreement coefficient and the reliability of Mi-T2 module was determined by Cronbach Alpha's value scale. The content validity of Mi-T2 module was 0.89 and the Cronbach Alpha's value of Mi-T2 module was 0.911.

  4. Development and validation of a computer-based learning module for wrist arthroscopy.

    Science.gov (United States)

    Obdeijn, M C; Alewijnse, J V; Mathoulin, C; Liverneaux, P; Tuijthof, G J M; Schijven, M P

    2014-04-01

    The objective of this study was to develop and validate a computer-based module for wrist arthroscopy to which a group of experts could consent. The need for such a module was assessed with members of the European Wrist Arthroscopy Society (EWAS). The computer-based module was developed through several rounds of consulting experts on the content. The module's learning enhancement was tested in a randomized controlled trial with 28 medical students who were assigned to the computer-based module group or lecture group. The design process led to a useful tool, which is supported by a panel of experts. Although the computer based module did not enhance learning, the participants did find the module more pleasant to use. Developing learning tools such as this computer-based module can improve the teaching of wrist arthroscopy skills.

  5. Top at Twenty

    CERN Document Server

    2015-01-01

    The "Top at Twenty" workshop is dedicated to the celebration of 20 years since the top quark discovery at Fermilab in 1995. Speakers from all experiments capable of studying top quark, ATLAS, CDF, CMS and DZero, will present the most recent results of the top quark studies based on Run II of the Tevatron and Run I of the LHC. Reviews of such fundamental measurements as mass of the top quark, its spin, charge and production properties are planned with some of them orders of magnitude better in precision in comparison with original CDF and DZero papers announcing the top quark discovery. Measurements of top quark production and decay that illuminate the nature of the Higgs boson and seek new phenomena will be presented. Theoretical talks on how the top quark fits into the Standard Model and its potential extensions will also be presented. This workshop will complement the yearly Top Workshop which is held in September and will benefit from many new results expected to be presented at winter conferences in 2015...

  6. Development of a unique small molecule modulator of CXCR4.

    Directory of Open Access Journals (Sweden)

    Zhongxing Liang

    Full Text Available BACKGROUND: Metastasis, the spread and growth of tumor cells to distant organ sites, represents the most devastating attribute and plays a major role in the morbidity and mortality of cancer. Inflammation is crucial for malignant tumor transformation and survival. Thus, blocking inflammation is expected to serve as an effective cancer treatment. Among anti-inflammation therapies, chemokine modulation is now beginning to emerge from the pipeline. CXC chemokine receptor-4 (CXCR4 and its ligand stromal cell-derived factor-1 (CXCL12 interaction and the resulting cell signaling cascade have emerged as highly relevant targets since they play pleiotropic roles in metastatic progression. The unique function of CXCR4 is to promote the homing of tumor cells to their microenvironment at the distant organ sites. METHODOLOGY/PRINCIPAL FINDINGS: We describe the actions of N,N'-(1,4-phenylenebis(methylenedipyrimidin-2-amine (designated MSX-122, a novel small molecule and partial CXCR4 antagonist with properties quite unlike that of any other reported CXCR4 antagonists, which was prepared in a single chemical step using a reductive amination reaction. Its specificity toward CXCR4 was tested in a binding affinity assay and a ligand competition assay using (18F-labeled MSX-122. The potency of the compound was determined in two functional assays, Matrigel invasion assay and cAMP modulation. The therapeutic potential of MSX-122 was evaluated in three different murine models for inflammation including an experimental colitis, carrageenan induced paw edema, and bleomycin induced lung fibrosis and three different animal models for metastasis including breast cancer micrometastasis in lung, head and neck cancer metastasis in lung, and uveal melanoma micrometastasis in liver in which CXCR4 was reported to play crucial roles. CONCLUSIONS/SIGNIFICANCE: We developed a novel small molecule, MSX-122, that is a partial CXCR4 antagonist without mobilizing stem cells, which can

  7. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development

    Science.gov (United States)

    Gardner, Jonathan (Technical Monitor); Tolls, Volker

    2004-01-01

    The optical modulation spectrometer (OMS) is a novel, highly efficient, low mass backend for heterodyne receiver systems. Current and future heterodyne receiver systems operating at frequencies up to a few THz require broadband spectrometer backends to achieve spectral resolutions of R approximately 10(exp 5) to 10(exp 6) to carry out many important astronomical investigations. Among these are observations of broad emission and absorption lines from extra-galactic objects at high redshifts, spectral line surveys, and observations of planetary atmospheres. Many of these lines are pressure or velocity broadened with either large half-widths or line wings extending over several GHz. Current backend systems can cover the needed bandwidth only by combining the output of several spectrometers, each with typically up to 1 GHz bandwidth, or by combining several frequency-shifted spectra taken with a single spectrometer. An ultra-wideband optical modulation spectrometer with 10 - 40 GHz bandwidth will enable broadband ob- servations without the limitations and disadvantages of hybrid spectrometers. Spectrometers like the OMS will be important for both ground-based observatories and future space missions like the Single Aperture Far-Infrared Telescope (SAFIR) which might carry IR/submm array heterodyne receiver systems requiring a spectrometer for each array pixel. Small size, low mass and small power consumption are extremely important for space missions. This report summarizes the specifications developed for the OMS and lists already identified commercial parts. The report starts with a review of the principle of operation, then describes the most important components and their specifications which were derived from theory, and finishes with a conclusion and outlook.

  8. Development of Modulators Against Degenerative Aging Using Radiation Fusion Technology

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Sung Kee; Jung, U.; Park, H. R.

    2010-04-15

    In this study, we selected final 20 biomarkers for the degenerative aging to develop radiation aging modeling, and validated a few of selected markers to utilize them in the screening of aging modulators. To select the biomarkers of the degenerative aging, 4 categories of aging-related markers (immune/hematopoiesis, oxidative damage, signaling molecule, lipid metabolism) were comparatively analyzed in irradiated and normally aged biosystems (cell lines or mice). In result, most of the biomarkers showed similar changes by irradiation and normal aging. Regarding the immune/hematopoiesis, the decline of immune cell functions (lymphocyte, NK cell) and Th1/Th2 imbalance, and decreased antigen-presenting of dendritic cells were observed and 10 biomarkers were selected in this category. mtDNA deletion was selected for the oxidative damage marker, 6 biomarkers including p21 and p-FOXO3a for signaling molecule biomarkers, and 3 biomarkers including the adipose tissue weight were selected for lipid metabolism. In addition, the various radiation application conditions by single/factionated irradiation and the periods after the irradiation were investigated for the optimal induction of changes of biomarker, which revealed that total 5Gy of 10 or more fractionated irradiations and 4 months or greather period were observed to be optimal. To found the basis for the screening of natural aging modulators, some selected aging biomarkers were validated by their inhibition by well-known natural agents (EGCG, HemoHIM, etc) in aged cell or mouse model. Additionally, by evaluating the reductive efficacy of 5 natural agents on the degeneration of skin and reproductive organs induced by radiation and chemicals (cyclophosphamide, etc), we established the base for the screening of degenerative diseases by various factors

  9. Development of a medical module for disaster information systems.

    Science.gov (United States)

    Calik, Elif; Atilla, Rıdvan; Kaya, Hilal; Aribaş, Alirıza; Cengiz, Hakan; Dicle, Oğuz

    2014-01-01

    This study aims to improve a medical module which provides a real-time medical information flow about pre-hospital processes that gives health care in disasters; transferring, storing and processing the records that are in electronic media and over internet as a part of disaster information systems. In this study which is handled within the frame of providing information flow among professionals in a disaster case, to supply the coordination of healthcare team and transferring complete information to specified people at real time, Microsoft Access database and SQL query language were used to inform database applications. System was prepared on Microsoft .Net platform using C# language. Disaster information system-medical module was designed to be used in disaster area, field hospital, nearby hospitals, temporary inhabiting areas like tent city, vehicles that are used for dispatch, and providing information flow between medical officials and data centres. For fast recording of the disaster victim data, accessing to database which was used by health care professionals was provided (or granted) among analysing process steps and creating minimal datasets. Database fields were created in the manner of giving opportunity to enter new data and search old data which is recorded before disaster. Web application which provides access such as data entry to the database and searching towards the designed interfaces according to the login credentials access level. In this study, homepage and users' interfaces which were built on database in consequence of system analyses were provided with www.afmedinfo.com web site to the user access. With this study, a recommendation was made about how to use disaster-based information systems in the field of health. Awareness has been developed about the fact that disaster information system should not be perceived only as an early warning system. Contents and the differences of the health care practices of disaster information systems were

  10. Macrophage Polarization Modulates Development of Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Feng Li

    2015-10-01

    Full Text Available Background/Aims: Macrophages have recently been shown to play a critical role in the pathogenesis of systemic lupus erythematosus (SLE. However, the underlying mechanisms remain unclear. Methods: Here, we used an activated lymphocyte-derived DNA (ALD-DNA method to induce SLE in mice. We used a macrophage-specific eliminator clodronate to selectively deplete macrophages in mice. We isolated macrophages from bone marrow of the mice and used cytokines to differentiate M1 and M2 macrophages, respectively. Adoptive transplantation of M1 or M2 macrophages was performed in clodronate-treated mice. The effects on SLE were evaluated by serum anti-dsDNA autoantibody, by renal pathological changes, and by urine protein levels. Results: ALD-DNA induced SLE-like features in mice, manifested by induction of serum anti-dsDNA autoantibody, by renal pathological changes, and by increases in urine protein levels. Clodronate significantly decreased macrophages in mice, which significantly increased SLE severity. Adoptive transplantation of M2, but not M1 macrophages significantly reduced SLE severity in clodronate- and ALD-DNA-treated mice. Conclusion: M1 and M2 macrophages play different roles in development of SLE. M1 macrophages increase the severity of SLE, while M2 macrophages reduce it. Modulation of macrophage polarity may be an attractive therapy for SLE.

  11. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2002-07-10

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the April 1--June 30, 2002 time period.

  12. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-10-29

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the July 1--September 30, 2003 time period.

  13. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2003-01-30

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the October 1--December 31, 2002 time period.

  14. Development of Pressurized Circulating Fluidized Bed Partial Gasification Module (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    A. Robertson

    2002-09-30

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the July 1-September 30, 2002 time period.

  15. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-07-23

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the April 1--June 30, 2003 time period.

  16. Ultrafast Power Processor for Smart Grid Power Module Development

    Energy Technology Data Exchange (ETDEWEB)

    MAITRA, ARINDAM [EPRI; LITWIN, RAY [EPRI; lai, Jason [Enertronics; Syracuse, David [Silicon Power

    2012-12-30

    This project’s goal was to increase the switching speed and decrease the losses of the power semiconductor devices and power switch modules necessary to enable Smart Grid energy flow and control equipment such as the Ultra-Fast Power Processor. The primary focus of this project involves exploiting the new silicon-based Super-GTO (SGTO) technology and build on prototype modules already being developed. The prototype super gate-turn-off thyristor (SGTO) has been tested fully under continuously conducting and double-pulse hard-switching conditions for conduction and switching characteristics evaluation. The conduction voltage drop measurement results indicate that SGTO has excellent conduction characteristics despite inconsistency among some prototype devices. Tests were conducted with two conditions: (1) fixed gate voltage and varying anode current condition, and (2) fixed anode current and varying gate voltage condition. The conduction voltage drop is relatively a constant under different gate voltage condition. In terms of voltage drop as a function of the load current, there is a fixed voltage drop about 0.5V under zero current condition, and then the voltage drop is linearly increased with the current. For a 5-kV voltage blocking device that may operate under 2.5-kV condition, the projected voltage drop is less than 2.5 V under 50-A condition, or 0.1%. If the device is adopted in a converter operating under soft-switching condition, then the converter can achieve an ultrahigh efficiency, typically above 99%. The two-pulse switching test results indicate that SGTO switching speed is very fast. The switching loss is relatively low as compared to that of the insulated-gate-bipolar-transistors (IGBTs). A special phenomenon needs to be noted is such a fast switching speed for the high-voltage switching tends to create an unexpected Cdv/dt current, which reduces the turn-on loss because the dv/dt is negative and increases the turn-off loss because the dv/dt is

  17. Developing critical literacy in a PARFOR teaching practicum module

    Directory of Open Access Journals (Sweden)

    William Mineo Tagata

    2016-06-01

    Full Text Available Abstract: This paper aims to describe a distance education experience that took place in a teaching practicum module of PARFOR (National Plan for Educating Primary and Secondary School Teachers at the Federal University of Uberlândia. With the aim of promoting a discussion about race and ethnicity in Brazil, the materials and activities of this module were devised in a critical literacy perspective (KNOBEL AND LANKSHEAR, 2011; COPE AND KALANTZIS, 2012. The paper begins with a discussion of relevant issues concerning learning and literacy in distance education today, and then moves on to a brief description of this teaching practicum module. After an analysis of two tasks from this module, we conclude by reflecting on some of the shortcomings regarding the implementation of the course, and suggesting ways in which they could be overcome.

  18. Modulation of Rhamm (CD168) for selective adipose tissue development

    Energy Technology Data Exchange (ETDEWEB)

    Turley, Eva A; Bissell, Mina J

    2014-05-06

    Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.

  19. Developing Project Based Learning E-Module for the Course of Video Editing

    Directory of Open Access Journals (Sweden)

    Ketut Krisnayuni

    2017-04-01

    Full Text Available This study examined the development of an electronic module for the course of video editing and analyzed the students’ response of the e-module. A waterfall model was adopted in the development process of the e-module that consisted of five stages namely (1 analysis; (2 design; (3 implementation; (4 evaluation; and (5 maintenance. The subjects of this study were the students of class XI at SMK Negeri 1 Sukasada. Project Based Learning was used as the basis of the e-module development as the most relevant learning model to meet the students’needs and the schools’ situation. The data of the students’ response about the e-module were collected through a questionnaire. The students’ response was very positive indicated by the mean score of 94,37. It was concluded that the developed e-modul was categorized as very good.

  20. Development of combined Opto-Acoustical sensor Modules

    Energy Technology Data Exchange (ETDEWEB)

    Enzenhoefer, A., E-mail: alexander.enzenhoefer@physik.uni-erlangen.de [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erwin-Rommel-Str. 1, D-91058 Erlangen (Germany); Anton, G.; Graf, K.; Hoessl, J.; Katz, U.; Lahmann, R.; Neff, M.; Richardt, C. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erwin-Rommel-Str. 1, D-91058 Erlangen (Germany)

    2012-01-11

    The faint fluxes of cosmic neutrinos expected at very high energies require large instrumented detector volumes. The necessary volumes in combination with a sufficient shielding against background constitute forbidding and complex environments (e.g. the deep sea) as sites for neutrino telescopes. To withstand these environments and to assure the data quality, the sensors have to be reliable and their operation has to be as simple as possible. A compact sensor module design including all necessary components for data acquisition and module calibration would simplify the detector mechanics and ensures the long term operability of the detector. The compact design discussed here combines optical and acoustical sensors inside one module, therefore reducing electronics and additional external instruments for calibration purposes. In this design the acoustical sensor is primary used for acoustic positioning of the module. The module may also be used for acoustic particle detection and marine science if an appropriate acoustical sensor is chosen. First tests of this design are promising concerning the task of calibration. To expand the field of application also towards acoustic particle detection further improvements concerning electromagnetic shielding and adaptation of the single components are necessary.

  1. Detector module development for the CBM silicon tracking system

    Energy Technology Data Exchange (ETDEWEB)

    Bertini, Olga [GSI Helmholtzzentrum, Darmstadt (Germany); Collaboration: CBM-Collaboration

    2014-07-01

    The central detector of the CBM experiment at FAIR, the Silicon Tracking System (STS), is designed to reconstruct hundreds of charged particle tracks produced at rates up to 10 MHz in interactions of ion beams of up to 45 AGeV projectile energies with nuclear targets. The building block of the tracking system is a module suitable for a low-mass detector construction. In a module, the basic functional unit of the STS, radiation tolerant microstrip sensors are read out through low-mass multi-line cables with self-triggering front-end electronics located at the periphery of the system. Light-weight carbon fibre support structures will carry 10 of such modules and build up the STS stations. The performance of module prototypes has been evaluated, resembling the structure of the intended STS module. The shown prototypes comprise a full-size CBM05 sensor and two 128-channel read-out cables attached to the read-out pads on either side of the sensor. The cables end in connector boards interfacing to two front-end boards each hosting one n-XYTER chip.

  2. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-03-29

    Foster Wheeler Development Corporation is working under DOE contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% while producing near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The unique aspect of the process is that it utilizes a pressurized circulating fluidized bed partial gasifier and does not attempt to consume the coal in a single step. To convert all the coal to syngas in a single step requires extremely high temperatures ({approx}2500 to 2800 F) that melt and vaporize the coal and essentially drive all coal ash contaminants into the syngas. Since these contaminants can be corrosive to power generating equipment, the syngas must be cooled to near room temperature to enable a series of chemical processes to clean the syngas. Foster Wheeler's process operates at much lower temperatures that control/minimize the release of contaminants; this eliminates/minimizes the need for the expensive, complicated syngas heat exchangers and chemical cleanup systems typical of high temperature gasification. By performing the gasification in a circulating bed, a significant amount of syngas can still be produced despite the reduced temperature and the circulating bed allows easy scale up to large size plants. Rather than air, it can also operate with oxygen to facilitate

  3. Outlook: The Next Twenty Years

    Energy Technology Data Exchange (ETDEWEB)

    Murayama, Hitoshi

    2003-12-07

    I present an outlook for the next twenty years in particle physics. I start with the big questions in our field, broken down into four categories: horizontal, vertical, heaven, and hell. Then I discuss how we attack the bigquestions in each category during the next twenty years. I argue for a synergy between many different approaches taken in our field.

  4. 78 FR 17220 - Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) As...

    Science.gov (United States)

    2013-03-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Request for Information (RFI) Regarding the Planned Biotechnology Development Module (BDM) As Part... for the planned Biotechnology Development Module (BDM) a planned component of the National Bio...

  5. Effect of Career Education Module on Career Development of Community College Students

    Science.gov (United States)

    Talib, Jasmi A.; Salleh, Amla; Amat, Salleh; Ghavifekr, Simin; Ariff, Azlinda M.

    2015-01-01

    Using a pre-post and control group design, we examined the effect of a career education module on career development among a group of 122 community college students in Malaysia. The effect of gender and the interaction effect of gender and career education module on career development were also investigated. MANOVA analyses showed significant…

  6. Preparing Preservice Teachers for Instruction on English-Language Development with Video Lesson Modules

    Science.gov (United States)

    Liu, Ping

    2011-01-01

    This study explored the use of video lesson modules in a teaching methodology course to prepare preservice teachers for supporting the English-language development of pupils at K-8 schools. The basic material of a lesson module is a video lesson featuring instruction of an experienced classroom teacher in an English-language development setting of…

  7. The Development of COBOL and RPG Instructional Modules to Audit Computerized Accounting Systems.

    Science.gov (United States)

    Skudrna, Vincent J.

    1982-01-01

    Details steps involved (as found in the literature) in the systems approach to design and develop instruction in order to provide a rationale for the development of instructional modules in COBOL and RPG to teach accounting students how to audit computerized accounting systems. Outlines of two modules are appended. (EAO)

  8. Development of intergrated accident management assessment technology; development of interface modules of risk-monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S. K.; Park, S. K.; Seok, H.; Kim, D. K.; Han, J. K.; Park, B. R. [KOPEC, Taejeon (Korea)

    2002-03-01

    Based on the development of interface modules with FORTE.- DynaRM can quantify risk model very fast (Very frequent risk model quantification is needed for configuration risk management).- risk monitoring system technology transfer to foreign NPPs. Contribution to component failure and maintenance control automation with the development of Tagging control System. On-Line risk monitoring system development by joint team between Korea Atomic Energy Research Institute and KOPEC is a request by KEPCO. The softwares developed in this study is easily implemented at domestic NPPs without extra study or cost. Economic benefit and Software export to foreign NPPs are expected because of the development of technology related to risk monitoring system and its management. 6 refs., 3 figs., 1 tab. (Author)

  9. Research and development of peripheral technology for photovoltaic power systems. Research and development of photovoltaic modules integrated with construction materials (detachable plane panel); Shuhen gijutsu no kenkyu kaihatsu. Kenzai ittaigata module no kenkyu kaihatsu (chakudatsushiki heiban panel)

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuta, M. [New Energy and Industrial Technology Development Organization, Tokyo (Japan)

    1994-12-01

    This paper reports the study results on R and D of photovoltaic modules integrated with construction materials in fiscal 1994. (1) On development of technology for module structures, specifications of the horizontal muntin system module were newly determined in addition to the improved muntin system module, and the prototype pseudo-module integrated with construction material was prepared. The comparison results of the basic performance of both system modules clarified superior waterproofing and module temperature uniformity of the horizontal muntin system. Based on this specifications, integration technology of modules with back metal plates was studied. Formation of the integrated module close to final specifications was ascertained to be possible by use of passivation equipment to irregular form. (2) On development of construction and installation methods of modules, improvement of the waterproofing and workability of both system modules was studied. (3) On the study on practical use of modules, their design and ventilation/cooling structure were studied. 38 figs., 13 tabs.

  10. Moderated heat pipe thermionic reactor (MOHTR) module development and test

    Science.gov (United States)

    Merrigan, Michael A.; Trujillo, Vincent L.

    1992-01-01

    The Moderated Heat Pipe Thermionic Reactor (MOHTR) thermionic space reactor design combines the low risk technology associated with the Thermionic Fuel Element (TFE) Verification Program with the high reliability heat transfer capability of liquid metal heat pipe technology. The resulting design concept, capable of implementation over the power range of 10 to 100 kWe, offers efficiency and reliability with reduced risk of single point failures. The union of TFE and heat pipe technology is achieved by imbedding TFEs and heat pipes in a beryllium matrix to which they are thermally coupled by brazing or by liquid metal (NaK or Na) bonding. The reactor employs an array of TFE modules, each comprising a TFE, a zirconium hydride (ZrH) cylinder for neutron moderation, and heat pipes for transport of heat from the collector surface of the TFE to the waste heat radiator. An advantage of the design is the low temperature drop from the collector surface to the radiating surface. This is a result of the elimination of electrical insulation from the heat transport path through electrical isolation of the modules. The module used in this study consisted of a beryllium core, and electrical cartridge heater simulating the TFE, and three heat pipes to dissipate the waste heat. The investigation was focused on the thermal performance of the assembly, including evaluation of the sodium and braze bonding options for minimizing the thermal resistance between the elements, the temperature distribution in the beryllium matrix, and the heat pipe performance. Continuing subjects of the investigation include performance of the heat pipes through start-up transients, during normal operation, and in a single heat pipe failure mode. Secondary objectives of the investigation include correlation of analytic models for the thermionic element and module including the effects of gap thermal conductances at the modules electrically insulated surfaces.

  11. A New Approach to Developing Interactive Software Modules through Graduate Education

    CERN Document Server

    Sanders, Nathan E; Goodman, Alyssa A

    2013-01-01

    We discuss a set of fifteen new interactive, educational, online software modules developed by Harvard University graduate students to demonstrate various concepts related to astronomy and physics. Their achievement demonstrates that online software tools for education and outreach on specialized topics can be produced while simultaneously fulfilling project-based learning objectives. We describe a set of technologies suitable for module development and present in detail four examples of modules developed by the students. We offer recommendations for incorporating educational software development within a graduate curriculum and conclude by discussing the relevance of this novel approach to new online learning environments like edX.

  12. Development of Prototype Outcomes-Based Training Modules for Aesthetic Dentistry

    Directory of Open Access Journals (Sweden)

    Maricar Joy T. Andres

    2015-06-01

    Full Text Available The objective of the study is to know the essential components of Aesthetic Dentistry that will be a basis for prototype Outcomes-based training modules. Using a 5-point Likert scale, the researcher-made questionnaire assessed the different elements of Aesthetic Dentistry which are needed in the designing of the training module, the manner of presentation and the form of assessment that were needed in the training module. Statistical tools that were used for the study are percentage, frequency, weighted mean and standard deviation. The information gathered from the respondents was relevant in the development of a Prototype Outcomes-based Training Modules in Aesthetic Dentistry.

  13. Development of Community College Instructional Modules for Biology and Comparative Vertebrate Anatomy.

    Science.gov (United States)

    Vasiliauskas, Jura B.

    A project was undertaken to: (1) formulate objectives for a biology unit dealing with frog dissection and vertebrate anatomy, (2) on the basis of these objectives, develop self-instructional modules utilizing audio-visual and printed instructional materials, and (3) formulate instruments for the evaluation of the modules. The rationale for the…

  14. Broadening Student Perspectives on Marketing Research Ethics: Development and Applications of a Teaching Module

    Science.gov (United States)

    Handlin, Amy

    2012-01-01

    This paper describes an ethics module developed by the author to engage marketing research students during the fall semester, when they are bombarded by political polls. The module matches ethically questionable polling practices to similarly troubling practices in marketing research. The goals are to show that ethical principles are not topic- or…

  15. Development of Hybrid Courses Utilizing Modules as an Objective in ATE Projects

    Science.gov (United States)

    Payne, James E.; Murphy, Richard M.; Payne, Linda L.

    2017-01-01

    Orangeburg-Calhoun Technical College (OCtech) has been awarded two National Science Foundation Advanced Technological Education (NSF-ATE) grants since 2011 that have the development of module-based hybrid courses in Engineering Technology and Mechatronics as objectives. In this article, the advantages and challenges associated with module-based…

  16. Barbering/Cosmetology, Module 6-10: Bilingual Vocational Language Development Workbook.

    Science.gov (United States)

    Northern New Mexico Community Coll., El Rito.

    This vocabulary language development workbook accompanies modules 6-10 in the barbering/cosmetology course of the Bilingual Skills Training Program (CE 028 314-318). For each module the trade-related vocabulary to be learned and practiced is first presented in both English and Spanish. Various types of activities and exercises using both the…

  17. Development of 24GHz Rectenna for Receiving and Rectifying Modulated Waves

    Science.gov (United States)

    Shinohara, Naoki; Hatano, Ken

    2014-11-01

    In this paper, we show experimental results of RF-DC conversion with modulated 24GHz waves. We have already developed class-F MMIC rectenna with resonators for higher harmonics at no modulated 24GHz microwave for RF energy transfer. Dimensions of the MMIC rectifying circuit is 1 mm × 3 mm on GaAs. Maximum RF-DC conversion efficiency is measured 47.9% for a 210 mW microwave input of 24 GHz with a 120 Ω load. The class-F rectenna is based on a single shunt full-wave rectifier. For future application of a simultaneous energy and information transfer system or an energy harvesting from broadcasting waves, input microwave will be modulated. In this paper, we show an experimental result of RF-DC conversion of the class-F rectenna with 24GHz waves modulated by 16QAM as 1st modulation and OFDM as 2nd modulation.

  18. Development of a Visual Inspection Data Collection Tool for Evaluation of Fielded PV Module Condition

    Energy Technology Data Exchange (ETDEWEB)

    Packard, C. E.; Wohlgemuth, J. H.; Kurtz, S. R.

    2012-08-01

    A visual inspection data collection tool for the evaluation of fielded photovoltaic (PV) modules has been developed to facilitate describing the condition of PV modules with regard to field performance. The proposed data collection tool consists of 14 sections, each documenting the appearance or properties of a part of the module. This report instructs on how to use the collection tool and defines each attribute to ensure reliable and valid data collection. This tool has been evaluated through the inspection of over 60 PV modules produced by more than 20 manufacturers and fielded at two different sites for varying periods of time. Aggregated data from such a single data collection tool has the potential to enable longitudinal studies of module condition over time, technology evolution, and field location for the enhancement of module reliability models.

  19. Development and application of visual support module for remote operator in 3D virtual environment

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Kyung Hyun; Cho, Soo Jeong; Yang, Kyung Boo [Cheju Nat. Univ., Jeju (Korea, Republic of); Bae, Chang Hyun [Pusan Nat. Univ., Busan (Korea, Republic of)

    2006-02-15

    In this research, the 3D graphic environment was developed for remote operation, and included the visual support module. The real operation environment was built by employing a experiment robot, and also the identical virtual model was developed. The well-designed virtual models can be used to retrieve the necessary conditions for developing the devices and processes. The integration of 3D virtual models, the experimental operation environment, and the visual support module was used for evaluating the operation efficiency and accuracy by applying different methods such as only monitor image and with visual support module.

  20. Pulse Power Hybrid Energy Storage Module Development Program

    Science.gov (United States)

    2015-05-01

    simulation results were shown in Fig. 11.) 28 14. One of the two reference MatLab Simulink models for the study of the effect of HESMs and a pulsed load...the Megawatt Power Module 44 25 Block diagram of the MPM system - two flywheels per skid configuration 45 26 MatLab Simulink model of a two...Network McKttile Fig. 14. One of the two reference MatLab Simulink models for the study of the effect of HESMs and a pulsed load on a ship’s power

  1. Recent developments in electroabsorption modulators at Acreo Swedish ICT

    Science.gov (United States)

    Wang, Qin; Zhang, Andy Z.; Almqvist, Susanne; Junique, Stephane; Noharet, Bertrand; Platt, Duncan; Salter, Michael; Andersson, Jan Y.

    2015-03-01

    Three types of electroabsorption modulators (EAMs) based on III-V semiconductor multiple quantum wells (MQW) are presented in this work. One is a novel monolithic integration traveling-wave EAM for an analog optical transmitter/transceiver to achieve integrated photonic mm-wave functions for broadband connectivity. Another one is composed of an integrated EAM 1D array in a photonic beam-former as a Ku-band phased array antenna for seamless aeronautical networking through integration of data links, radios, and antennas. The third one addresses the use of MQW EAMs in free space optical links through biological tissue for transcutaneous communication.

  2. Pulse Power Modulator development for the CLIC Damping Ring Kickers

    CERN Document Server

    Holma, Janne

    2012-01-01

    The Compact Linear Collider (CLIC) study is exploring the scheme for an electron-positron collider with high luminosity (10-34 – 10-35 cm-2s-1) and a nominal centre-of-mass energy of 3 TeV: CLIC would complement LHC physics in the multi-TeV range. The CLIC design relies on Pre-Damping Rings (PDR) and Damping Rings (DR) to achieve the very low emittance, through synchrotron radiation, needed for the luminosity requirements of CLIC. To limit the beam emittance blow-up due to oscillations, the pulse power modulators for the DR kickers must provide extremely flat, high-voltage pulses: the 2 GHz specification called for a 160 ns duration flat-top of 12.5 kV, 250 A, with a combined ripple and droop of not more than ±0.02 %. In order to meet these demanding specifications, a combination of broadband impedance matching, optimized electrical circuit layout and advanced control techniques is required. A solid-state modulator, the inductive adder, is the most promising approach to meeting the demanding specifications...

  3. Developing an evaluation plan for an e-learning module to develop higher-order thinking skills and writing competences

    OpenAIRE

    2007-01-01

    This article presents the experience of developing an evaluation plan for an e-learning module designed to foster higher-order thinking skills and writing competences. The evaluation plan is under construction and while the author is not in a position to provide an example of good practice, this article hopes to share the experience of developing an evaluation plan for an e-learning module.

  4. Low cost solar array project production process and equipment task. A Module Experimental Process System Development Unit (MEPSDU)

    Science.gov (United States)

    1981-01-01

    Technical readiness for the production of photovoltaic modules using single crystal silicon dendritic web sheet material is demonstrated by: (1) selection, design and implementation of solar cell and photovoltaic module process sequence in a Module Experimental Process System Development Unit; (2) demonstration runs; (3) passing of acceptance and qualification tests; and (4) achievement of a cost effective module.

  5. Development and Evaluation of a Series of CAL Modules on Cell Biology for Undergraduate Nursing Students.

    Science.gov (United States)

    Wharrad, Heather; Kent, Christine; Allcock, Nick; Wood, Barry

    2000-01-01

    Describes a project at the University of Nottingham (United Kingdom) that developed and evaluated modules for computer assisted instruction to teach cell biology to undergraduate nursing students. Topics include instructional effectiveness, feedback, and student attitudes. (LRW)

  6. Inspiring Climate Education Excellence(ICEE): Developing Elearning professional development modules - secondary science teachers

    Science.gov (United States)

    Kellagher, E.; Buhr, S. M.; Lynds, S. E.; McCaffrey, M. S.; Cires Education Outreach

    2011-12-01

    Inspiring Climate Education Excellence (ICEE) is a NASA-funded project to develop content knowledge and knowledge of effective teaching strategies in climate education among secondary science teachers. ICEE resources are aligned with the Essential Principles of Climate Science. Building upon a needs assessment and face to face workshop, ICEE resources include iTunesU videos, an ICEE 101 resource site with videos and peer-reviewed learning activities, and a moderated online forum. Self-directed modules and an online course are being developed around concepts and topics in which teachers express the most interest and need for instruction. ICEE resources include attention to effective teaching strategies, such as awareness of student misconceptions, strategies for forestalling controversy and advice from master teachers on implementation and curriculum development. The resources are being developed in partnership with GLOBE, and the National Science Digital Library (NSDL) and are informed by the work of the Climate Literacy and Energy Awareness Network (CLEAN) project. ICEE will help to meet the professional development needs of teachers, including those participating in the GLOBE Student Climate Research Campaign.

  7. Modulation of immune development and function by intestinal microbiota.

    Science.gov (United States)

    Kabat, Agnieszka M; Srinivasan, Naren; Maloy, Kevin J

    2014-11-01

    The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. DEVELOPMENT OF BUSINESS SKILLS MODULE FOR HUMAN CAPITAL MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Moré, Dailien

    2015-12-01

    Full Text Available Today firms advocate buy a business improvement depends on proper reach staff selection considering the level of commitment, work attitude, skills and competencies of each person in the performance of the functions of the various fees and jobs. This research proposes a module occupational competency (CL that would strengthen the Human Capital Management (GCH. The proposal may encourage national institutions and increase their productivity sustained employment success for the country. For the realization of the solution was carried out the study of business processes and methods of multicriterial decision-making. Following the completion of the design, the solution was implemented and the identified components were integrated, the results of the data obtained showed the feasibility of the contribution to the solution of the problem.

  9. Advancing clinical development pathways for new CFTR modulators in cystic fibrosis.

    Science.gov (United States)

    Mayer-Hamblett, Nicole; Boyle, Michael; VanDevanter, Donald

    2016-05-01

    Cystic fibrosis (CF) is a life-shortening genetic disease affecting approximately 70,000 individuals worldwide. Until recently, drug development efforts have emphasised therapies treating downstream signs and symptoms resulting from the underlying CF biological defect: reduced function of the CF transmembrane conductance regulator (CFTR) protein. The current CF drug development landscape has expanded to include therapies that enhance CFTR function by either restoring wild-type CFTR protein expression or increasing (modulating) the function of mutant CFTR proteins in cells. To date, two systemic small-molecule CFTR modulators have been evaluated in pivotal clinical trials in individuals with CF and specific mutant CFTR genotypes that have led to regulatory review and/or approval. Advances in the discovery of CFTR modulators as a promising new class of therapies have been impressive, yet work remains to develop highly effective, disease-modifying modulators for individuals of all CF genotypes. The objectives of this review are to outline the challenges and opportunities in drug development created by systemic genotype-specific CFTR modulators, highlight the advantages of sweat chloride as an established biomarker of CFTR activity to streamline early-phase development and summarise options for later phase clinical trial designs that respond to the adoption of approved genotype-specific modulators into standard of care. An optimal development framework will be needed to move the most promising therapies efficiently through the drug development pipeline and ultimately deliver efficacious and safe therapies to all individuals with CF.

  10. Specialization and Instantiation Aspects of a Standard Process for Developing Educational Modules

    Science.gov (United States)

    Barbosa, Ellen Francine; Maldonado, José Carlos

    Educational modules can be seen as relevant mechanisms to improve the learning processes in general. The goal is to produce quality educational products, capable of motivating the learners and effectively contribute to their knowledge construction process. Despite their relevance, none of the initiatives to address the problem of creating educational modules considers a systematic process for developing them. The establishment of a well-defined set of guidelines and supporting mechanisms should ease the distributed and cooperative work to create, reuse and evolve educational modules, taking also into account the impact on the learning process. In this work we present a standardized process we have established aiming at creating well-designed, highly flexible and configurable educational modules. We focus on the aspects of process specialization and instantiation, illustrating the practical application of the instantiated process by the development of an educational module for teaching the fundamentals of software testing. Particularly, the availability of learning facilities, allied to the development of testing tools, should facilitate the apprenticeship of specific testing theories and skills, promoting better dissemination conditions to the practical evaluation and application of testing strategies, both in academic and industrial sets. The produced module has been applied and preliminarily evaluated in terms of the learning effectiveness. The results obtained give us some evidences on the practical use of the standard process as a supporting mechanism to the development of effective educational modules.

  11. A new project for developing a prototype COIL module at Miki Pulley

    Science.gov (United States)

    Tei, Kazuyoku; Sugimoto, Daichi; Ito, T.; Watanabe, Goro; Vyskubenko, Oleg; Takeuchi, Noriyuki; Fujioka, Tomoo

    2003-11-01

    Miki Pulley has pursued the development of a prototype COIL module for field and industrial applications since its transfer from Tokai University in 2000. The test module has already been constructed in our laboratory. The current status of the development is presented. The achieved chemical efficiency was 17.5% at the chlorine flow rate of 13.2mol/min. The corresponding laser power was 3.5kW.

  12. Servicing the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Fisk, D. [DTLR, London (United Kingdom)

    2002-04-01

    Twentieth century governments have committed themselves to the principle of sustainable development. Efforts to fulfil this goal offer an insight into changes in building services provision in the opening decades of the new century. Sustainable development indicators are used to identify possible trends. The analysis also forms the basis for some speculative conjectures as a basis for a research agenda for the twenty-first century. (Author)

  13. Twenty-first century vaccinomics innovation systems: capacity building in the global South and the role of Product Development Partnerships (PDPs).

    Science.gov (United States)

    Huzair, Farah; Borda-Rodriguez, Alexander; Upton, Mary

    2011-09-01

    The availability of sequence information from publicly available complete genomes and data intensive sciences, together with next-generation sequencing technologies offer substantial promise for innovation in vaccinology and global public health in the beginning of the 21st century. This article presents an innovation analysis for the nascent field of vaccinomics by describing one of the major challenges in this endeavor: the need for capacities in "vaccinomics innovation systems" to support the developing countries involved in the creation and testing of new vaccines. In particular, we discuss the need for understanding how institutional frameworks can enhance capacities as intrinsic to a systems approach to health technology development. We focus our attention on the global South, meaning the technically less advanced and developing nations in Africa, Asia, and Latin America. This focus is timely and appropriate because the challenge for innovation in postgenomics medicine is markedly much greater in these regions where basic infrastructures are often underresourced and new or the anticipated institutional relationships can be fragile. Importantly, we examine the role of Product Development Partnerships (PDPs) as a 21st century organizational innovation that contributes to strengthening fragile institutions and capacity building. For vaccinomics innovation systems to stand the test of time in a context of global public health, local communities, knowledge, and cultures need to be collectively taken into account at all stages in programs for vaccinomics-guided vaccine development and delivery in the global South where the public health needs for rational vaccine development are urgent.

  14. Development of an aerosol microphysical module: Aerosol Two-dimensional bin module for foRmation and Aging Simulation (ATRAS

    Directory of Open Access Journals (Sweden)

    H. Matsui

    2014-04-01

    Full Text Available Number concentrations, size distributions, and mixing states of aerosols are essential parameters for accurate estimation of aerosol direct and indirect effects. In this study, we develop an aerosol module, designated Aerosol Two-dimensional bin module for foRmation and Aging Simulation (ATRAS, that can represent these parameters explicitly by considering new particle formation (NPF, black carbon (BC aging, and secondary organic aerosol (SOA processes. A two-dimensional bin representation is used for particles with dry diameters from 40 nm to 10 μm to resolve both aerosol size (12 bins and BC mixing state (10 bins for a total of 120 bins. The particles with diameters from 1 to 40 nm are resolved using an additional 8 size bins to calculate NPF. The ATRAS module is implemented in the WRF-chem model and applied to examine the sensitivity of simulated mass, number, size distributions, and optical and radiative parameters of aerosols to NPF, BC aging and SOA processes over East Asia during the spring of 2009. BC absorption enhancement by coating materials is about 50% over East Asia during the spring, and the contribution of SOA processes to the absorption enhancement is estimated to be 10–20% over northern East Asia and 20–35% over southern East Asia. A clear north-south contrast is also found between the impacts of NPF and SOA processes on cloud condensation nuclei (CCN concentrations: NPF increases CCN concentrations at higher supersaturations (smaller particles over northern East Asia, whereas SOA increases CCN concentrations at lower supersaturations (larger particles over southern East Asia. Application of ATRAS to East Asia also shows that the impact of each process on each optical and radiative parameter depends strongly on the process and the parameter in question. The module can be used in the future as a benchmark model to evaluate the accuracy of simpler aerosol models and examine interactions between NPF, BC aging, and SOA

  15. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Nellist, Clara; The ATLAS collaboration

    2016-01-01

    Summary ATLAS is preparing for an extensive modification of its detector in the course of the planned HL‐ LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all‐silicon detector (Inner Tracker, ITk). A revised trigger and data taking system is foreseen with triggers expected at lowest level at an average rate of 1 MHz. The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL‐LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice that is expected to take place in early 2017. A new on‐detector readout chip is designed in the context of the RD53 collaboration in 65 nm CMOS technology. This paper will present the on‐going R&D within the ATLAS ITK project towards the new pixel modules and the off‐detector electronics. Pla...

  16. Module and electronics developments for the ATLAS ITK pixel system

    CERN Document Server

    Munoz Sanchez, Francisca Javiela; The ATLAS collaboration

    2017-01-01

    ATLAS is preparing for an extensive modification of its detector in the course of the planned HL-LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m2, depending on the final layout choice that is expected to take place in 2017. A new on-detector readout chip is designed in the context of the RD53 collaboration in 65 nm CMOS technology. This paper will present the on-going R&D within the ATLAS ITK project towards the new pixel modules and the off-detector electronics. Planar and 3D sensors are being re-designed with cell sizes of 50x50 or 25x100 μm2, compatible with the RD53 chip. A sensor thickness equal or less th...

  17. Production and utilization of coal in the Russian Federation current situation and development strategy for the beginning of the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Zykov, V.M. [Union of Coal Producers of the Russian Federation, Moscow (Russian Federation)

    1999-08-09

    The paper assesses the main objectives of the reform process for the coal industry in Russia, initiated in 1993/94 and approved in July 1995. The following possibilities should expand coal production and use in Russia: attracting additional investment; lowering rail tariffs for coal transport; regulating the price ratio for energy carriers; developing coal beneficiation and processing; developing the application of environmentally friendly technologies throughout the coal cycle; and disposing of coal industry waste in an environmentally friendly way. 3 figs., 1 tab.

  18. Development of a Burnup Module DECBURN Based on the Krylov Subspace Method

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Shim, H. J.; Song, J. S

    2008-05-15

    This report is to develop a burnup module DECBURN that is essential for the reactor analysis and the assembly homogenization codes to trace the fuel composition change during the core burnup. The developed burnup module solves the burnup equation by the matrix exponential method based on the Krylov Subspace method. The final solution of the matrix exponential is obtained by the matrix scaling and squaring method. To develop DECBURN module, this report includes the followings as: (1) Krylov Subspace Method for Burnup Equation, (2) Manufacturing of the DECBURN module, (3) Library Structure Setup and Library Manufacturing, (4) Examination of the DECBURN module, (5) Implementation to the DeCART code and Verification. DECBURN library includes the decay constants, one-group cross section and the fission yields. Examination of the DECBURN module is performed by manufacturing a driver program, and the results of the DECBURN module is compared with those of the ORIGEN program. Also, the implemented DECBURN module to the DeCART code is applied to the LWR depletion benchmark and a OPR-1000 pin cell problem, and the solutions are compared with the HELIOS code to verify the computational soundness and accuracy. In this process, the criticality calculation method and the predictor-corrector scheme are introduced to the DeCART code for a function of the homogenization code. The examination by a driver program shows that the DECBURN module produces exactly the same solution with the ORIGEN program. DeCART code that equips the DECBURN module produces a compatible solution to the other codes for the LWR depletion benchmark. Also the multiplication factors of the DeCART code for the OPR-1000 pin cell problem agree to the HELIOS code within 100 pcm over the whole burnup steps. The multiplication factors with the criticality calculation are also compatible with the HELIOS code. These results mean that the developed DECBURN module works soundly and produces an accurate solution

  19. Pleiotropic Effects of Neurotransmission during Development: Modulators of Modularity

    Science.gov (United States)

    Thompson, Barbara L.; Stanwood, Gregg D.

    2009-01-01

    The formation and function of the mammalian cerebral cortex relies on the complex interplay of a variety of genetic and environmental factors through protracted periods of gestational and postnatal development. Biogenic amine systems are important neuromodulators, both in the adult nervous system, and during critical epochs of brain development.…

  20. Development of Active External Network Topology Module for Floodlight SDN Controller

    Directory of Open Access Journals (Sweden)

    A. A. Noskov

    2015-01-01

    Full Text Available Traditional network architecture is inflexible and complicated. This observation has led to a paradigm shift towards software-defined networking (SDN, where network management level is separated from data forwarding level. This change was made possible by control plane transfer from the switching equipment to software modules that run on a dedicated server, called the controller (or network operating system, or network applications, that work with this controller. Methods of representation, storage and communication interfaces with network topology elements are the most important aspects of network operating systems available to SDN user because performance of some key controller modules is heavily dependent on internal representation of the network topology. Notably, firewall and routing modules are examples of such modules. This article describes the methods used for presentation and storage of network topologies, as well as interface to the corresponding Floodlight modules. An alternative algorithm has been suggested and developed for message exchange conveying network topology alterations between the controller and network applications. Proposed algorithm makes implementation of module alerting based on subscription to the relevant events. API for interaction between controller and network applications has been developed. This algorithm and API formed the base for Topology Tracker module capable to inform network applications about the changes that had occurred in the network topology and also stores compact representation of the network to speed up the interaction process.

  1. Development of Vacuum Vessel Design and Analysis Module for CFETR Integration Design Platform

    Directory of Open Access Journals (Sweden)

    Chen Zhu

    2016-01-01

    Full Text Available An integration design platform is under development for the design of the China Fusion Engineering Test Reactor (CFETR. It mainly includes the integration physical design platform and the integration engineering design platform. The integration engineering design platform aims at performing detailed engineering design for each tokamak component (e.g., breeding blanket, divertor, and vacuum vessel. The vacuum vessel design and analysis module is a part of the integration engineering design platform. The main idea of this module is to integrate the popular CAD/CAE software to form a consistent development environment. Specifically, the software OPTIMUS provides the approach to integrate the CAD/CAE software such as CATIA and ANSYS and form a design/analysis workflow for the vacuum vessel module. This design/analysis workflow could automate the process of modeling and finite element (FE analysis for vacuum vessel. Functions such as sensitivity analysis and optimization of geometric parameters have been provided based on the design/analysis workflow. In addition, data from the model and FE analysis could be easily exchanged among different modules by providing a unifying data structure to maintain the consistency of the global design. This paper describes the strategy and methodology of the workflow in the vacuum vessel module. An example is given as a test of the workflow and functions of the vacuum vessel module. The results indicate that the module is a feasible framework for future application.

  2. Development of a Compact Wireless Laplacian Electrode Module for Electromyograms and Its Human Interface Applications

    Directory of Open Access Journals (Sweden)

    Akira Ichikawa

    2013-02-01

    Full Text Available In this study, we developed a compact wireless Laplacian electrode module for electromyograms (EMGs. One of the advantages of the Laplacian electrode configuration is that EMGs obtained with it are expected to be sensitive to the firing of the muscle directly beneath the measurement site. The performance of the developed electrode module was investigated in two human interface applications: character-input interface and detection of finger movement during finger Braille typing. In the former application, the electrode module was combined with an EMG-mouse click converter circuit. In the latter, four electrode modules were used for detection of finger movements during finger Braille typing. Investigation on the character-input interface indicated that characters could be input stably by contraction of (a the masseter, (b trapezius, (c anterior tibialis and (d flexor carpi ulnaris muscles. This wide applicability is desirable when the interface is applied to persons with physical disabilities because the disability differs one to another. The investigation also demonstrated that the electrode module can work properly without any skin preparation. Finger movement detection experiments showed that each finger movement was more clearly detectable when comparing to EMGs recorded with conventional electrodes, suggesting that the Laplacian electrode module is more suitable for detecting the timing of finger movement during typing. This could be because the Laplacian configuration enables us to record EMGs just beneath the electrode. These results demonstrate the advantages of the Laplacian electrode module.

  3. Risk profile of patients developing nonunion of the clavicle and outcome of treatment-analysis of fifty five nonunions in seven hundred and twenty nine consecutive fractures

    DEFF Research Database (Denmark)

    Ban, Ilija; Troelsen, Anders

    2016-01-01

    PURPOSE: The most common complication following treatment of a clavicle fracture is nonunion. Most nonunions are symptomatic and treatment is mostly operative. The aim of this study was to describe risk profiles of patients developing nonunion and what outcome is observed following operative...... treatment of clavicle nonunions. METHODS: In a consecutive series of 729 clavicle fractures we retrospectively identified 55 that developed nonunion (49 diaphysial and six lateral). All were treated operatively by reconstruction with (n = 28) or without (n = 27) autologous bone graft. Assessment...... was anatomic site, fracture complexity, female gender, smoking habits and initial treatment. A total of eight post-operative complications were found. Remission of symptoms was reported by 29 of the 33. Outright satisfaction with current shoulder condition was reported by 24. The overall median DASH was 8...

  4. Handling Uncertainties within R&D Modules of a developing Technology

    DEFF Research Database (Denmark)

    Pedersen, Jørgen Lindgaard; Perunovic, Zoran

    2004-01-01

    . Third, the modules that have had always been present in the insulin's R&D, enabled companies to develop mechanism for internal learning and are able to master that part of the process. Finally, in the R&D, outsourcing is related to the whole knowledge acquisition while it seems that minor uncertainties...... and an interview conducted have generated following. First, the further along the process train a module is, it accumulates uncertainties from previous modules. Second, with the growth of complexity, uncertainties grew as well, resulting in the necessity for companies to seek for knowledge on them externally...

  5. 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation

    Science.gov (United States)

    Simeonov, Yuri; Weber, Uli; Penchev, Petar; Printz Ringbæk, Toke; Schuy, Christoph; Brons, Stephan; Engenhart-Cabillic, Rita; Bliedtner, Jens; Zink, Klemens

    2017-09-01

    The purpose of this work was to design and manufacture a 3D range-modulator for scanned particle therapy. The modulator is intended to create a highly conformal dose distribution with only one fixed energy, simultaneously reducing considerably the treatment time. As a proof of concept, a 3D range-modulator was developed for a spherical target volume with a diameter of 5 cm, placed at a depth of 25 cm in a water phantom. It consists of a large number of thin pins with a well-defined shape and different lengths to modulate the necessary shift of the Bragg peak. The 3D range-modulator was manufactured with a rapid prototyping technique. The FLUKA Monte Carlo package was used to simulate the modulating effect of the 3D range-modulator and the resulting dose distribution. For that purpose, a special user routine was implemented to handle its complex geometrical contour. Additionally, FLUKA was extended with the capability of intensity modulated scanning. To validate the simulation results, dose measurements were carried out at the Heidelberg Ion Beam Therapy Center with a 400.41 MeV/u 12C beam. The high resolution dosimetric measurements show a good agreement between simulated and measured dose distributions. Irradiation of the monoenergetic raster plan took 3 s, which is approximately 20 times shorter than a comparable plan with 16 different energies. The combination of only one energy and a 3D range-modulator leads to a tremendous decrease in irradiation time. ‘Interplay effects’, typical for moving targets and pencil beam scanning, can be immensely reduced or disappear completely, making the delivery of a homogeneous dose to moving targets more reliable. Combining high dose conformity, very good homogeneity and extremely short irradiation times, the 3D range-modulator is considered to become a clinically applicable method for very fast treatment of lung tumours.

  6. Development of a photovoltaic module qualification test based on combined-environment accelerated stress data

    Science.gov (United States)

    Trenchard, S. E.; Royal, E.; Anderson, R. T.

    1982-01-01

    The U.S. Coast Guard has developed a qualification test to screen photovoltaic modules for utilization on marine aids to navigation. The test is based on a combined-environment of hot and cold saltwater immersion and air pressurization. The test has demonstrated a very high acceleration factor and excellent correlation of electrical failures with modules in a concurrent real-time marine exposure.

  7. Professional Teacher Education Module Series. Present Information with the Chalkboard and Flip Chart, Module C-29 of Category C--Instructional Execution.

    Science.gov (United States)

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This twenty-ninth in a series of twenty-nine learning modules on instructional execution is designed to give secondary and postsecondary vocational teachers help in developing the competencies needed to prepare and use chalkboards and flip charts in presenting information or illustrating lessons. Introductory sections relate the competencies dealt…

  8. Addressing the main challenges of energy security in the twenty-first century – Contributions of the conferences on Sustainable Development of Energy, Water and Environment Systems

    DEFF Research Database (Denmark)

    Markovska, Natasa; Duić, Neven; Mathiesen, Brian Vad

    2016-01-01

    biorefineries. Presenting the contributions of selected conference papers published in the special issues of leading scientific journals (including all the papers from the current Energy special issue), this review demonstrates the capacity of the Conferences on Sustainable Development of Energy, Water...... energy systems based on variable renewables; Electrifying the transport and some industrial processes; Liberalizing and extending the energy markets; Integrating energy sectors to Smart Energy Systems; Making the cities and communities smart; Diversifying the energy sources; and Building more......Climate change and fossil fuel reserve depletion both pose challenges for energy security and for wellbeing in general. The top ten among them include: Decarbonising the world economy; Enhancing the energy efficiency and energy savings in buildings; Advancing the energy technologies; Moving towards...

  9. The Tale of Two Virtual Teacher Professional Development Modules

    Science.gov (United States)

    Keown, Paul

    2009-01-01

    Virtual communities of practice (VCoP) have been advocated for some time as a promising means of taking professional development to teachers in widely distributed locations. However, geography, and indeed education literature as a whole, contains very few examples where this has been achieved. This paper reports on two VCoP professional…

  10. Rac1 modulates cardiomyocyte adhesion during mouse embryonic development

    Energy Technology Data Exchange (ETDEWEB)

    Abu-Issa, Radwan, E-mail: rabuissa@umich.edu

    2015-01-24

    Highlights: • Conditional knockout of Rac1 using Nkx2.5 Cre line is lethal at E13.5. • The myocardium of the mutant is thin and disorganized. • The phenotype is not due to cardiomyocyte low proliferation or apoptosis. • The phenotype is due to specific defect in cardiomyocyte adhesion. - Abstract: Rac1, a member of the Rho subfamily of small GTPases, is involved in morphogenesis and differentiation of many cell types. Here we define a role of Rac1 in cardiac development by specifically deleting Rac1 in the pre-cardiac mesoderm using the Nkx2.5-Cre transgenic driver line. Rac1-conditional knockout embryos initiate heart development normally until embryonic day 11.5 (E11.5); their cardiac mesoderm is specified, and the heart tube is formed and looped. However, by E12.5-E13.5 the mutant hearts start failing and embryos develop edema and hemorrhage which is probably the cause for the lethality observed soon after. The hearts of Rac1-cKO embryos exhibit disorganized and thin myocardial walls and defects in outflow tract alignment. No significant differences of cardiomyocyte death or proliferation were found between developing control and mutant embryos. To uncover the role of Rac1 in the heart, E11.5 primary heart cells were cultured and analyzed in vitro. Rac1-deficient cardiomyocytes were less spread, round and loosely attached to the substrate and to each other implying that Rac1-mediated signaling is required for appropriate cell–cell and/or cellmatrix adhesion during cardiac development.

  11. Simulation Analysis Module of High-speed Rail Bearings Based on Secondary Development in ADAMS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; YE Jun; XU Juan; LUO Yi-chao

    2013-01-01

    This paper develops a strong secondary development based on ADAMS feature which creates high-speed rail bearings for simulation analysis module. This thesis is in the case of non-circular pattern instructions of how to achieve rapid roller modeling, with analysis of functions and parameters required for the design of the simulation module of the high-speed rail bearing , as well as the design of dialog boxes, the environment and file structure. The specific modules is based on the secondary development language provided by ADAMS/View. Through the menus, dialog boxes which input parameters, it can achieve high iron bearing automatic modeling, dynamic analysis and post-processing to simplify the analysis of high-speed rail bearing operations, as well as improving the high-speed rail bearing development efficiency.

  12. Developing Telecommunications eLearning modules: Flexible performance support

    Directory of Open Access Journals (Sweden)

    John Sandler

    2008-08-01

    Full Text Available This article, in conjunction with a presentation at ICELW 2008 in New York, 12-13 June 2008, explores the successful application of eLearn development methodologies, planning processes, and a user-centred design consultative process. This development approach was applied during 2007, and continues through 2008, together with innovative and effective use of the Telstra eLearn platform, enabling the delivery of highly successful performance support solutions for Telstra field and technical support staff around Australia during 2007 and 2008. The integration of simulation and interaction into competency and learning checks, ensures that Telstra Corporation’s field work staff remain competent and capable of supporting emerging and changing technologies as continual enhancements keep being deployed to Telstra 3G networks to benefit customers in all facets of Australian life across the vast expanses of the country.

  13. [The development and transplantation of LCD module-based interface for medical diagnosis instrument].

    Science.gov (United States)

    Zhang, Huisheng; Liu, Xinyu; Li, Qiaoliang; Rao, Jie; Zhang, Xiaofei; Wang, Xiaoxuan; Lin, Shumei; Yin, Li; Chen, Siping; Wang, Tianfu

    2012-11-01

    Based on LCD Module and Visual C++ development environment, this paper proposes a new method which can quickly develop the human-machine interface .We define a LCD module programming interface by designing Serial Communication Class(SCS). On this basis,we achieve the transplantation on an Embedded ARM Platform to fulfil the requirements of Medical Diagnostic Instruments (MDI). Experimental results show that this method has advantages of short development cycle and high level transplantation which has broad application prospects in the field of Medical Diagnosis Instrument.

  14. Paraho oil shale module. Site development plan, Task 4

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    A management plan and schedule which covers all requirements for gaining access to the site and for conducting a Paraho Process demonstration program have been prepared. The oil shale available should represent a regional resource of suitable size and quality for commercial development. Discussed in this report are: proof of ownership; requirements for rights-of-way for access to the site; local zoning restrictions; water rights; site availability verification; and other legal requirements. (DMC)

  15. Development, characterization, and epitope mapping of a panel of twenty-four monoclonal antibodies specific for human inducible nitric oxide synthase.

    Science.gov (United States)

    Webber, Robert J; Rodriguez, John G; Webber, Douglas S; Dunnebacke, Thelma H

    2005-02-01

    A panel of monoclonal antibodies (MAbs) to human inducible nitric oxide synthase (hiNOS) has been developed. By isotype analysis of the MAbs cloned from the 24 different positive hybridomas, 13 were determined to be mouse IgG1, two were mouse IgG2a, two were mouse IgG2b, and the seven others were mouse IgM antibodies: all contained kappa light chains. The anti-hiNOS MAbs were initially characterized by ELISA, RIA, Western blot, and immunocytochemistry, and then they were epitope mapped using synthetic peptides and a three-step mapping procedure. In the first step, each of the 24 MAbs was tested by indirect ELISA for binding to 96 overlapping 18-amino acid-long peptides that span the entire 1153-amino acid length of hiNOS. Eight IgG class anti-hiNOS MAbs were found to bind to one of five different peptides. In the second step, a series of amino terminal and carboxyl terminal truncated peptides were synthesized for each of the five peptides to which one or more of the MAbs bound. Each of the eight anti-hiNOS MAbs was found to bind to the truncated peptides with a unique specificity that identified the amino acid segment involved in binding. The third step in the epitope mapping process utilized three series of overlapping 5-, 6-, 7-, 8-, and 9-amino acid-long peptides for each of these segments and identified the exact amino acids of hiNOS involved in antibody binding. Anti-hiNOS MAbs 2A1-F8, 2D2-B2, 21C10-1D10, and 24B10-2C7 were found to be especially useful in different immunoassays.

  16. RSK2 is a modulator of craniofacial development.

    Science.gov (United States)

    Laugel-Haushalter, Virginie; Paschaki, Marie; Marangoni, Pauline; Pilgram, Coralie; Langer, Arnaud; Kuntz, Thibaut; Demassue, Julie; Morkmued, Supawich; Choquet, Philippe; Constantinesco, André; Bornert, Fabien; Schmittbuhl, Matthieu; Pannetier, Solange; Viriot, Laurent; Hanauer, André; Dollé, Pascal; Bloch-Zupan, Agnès

    2014-01-01

    The RSK2 gene is responsible for Coffin-Lowry syndrome, an X-linked dominant genetic disorder causing mental retardation, skeletal growth delays, with craniofacial and digital abnormalities typically associated with this syndrome. Craniofacial and dental anomalies encountered in this rare disease have been poorly characterized. We examined, using X-Ray microtomographic analysis, the variable craniofacial dysmorphism and dental anomalies present in Rsk2 knockout mice, a model of Coffin-Lowry syndrome, as well as in triple Rsk1,2,3 knockout mutants. We report Rsk mutation produces surpernumerary teeth midline/mesial to the first molar. This highly penetrant phenotype recapitulates more ancestral tooth structures lost with evolution. Most likely this leads to a reduction of the maxillary diastema. Abnormalities of molar shape were generally restricted to the mesial part of both upper and lower first molars (M1). Expression analysis of the four Rsk genes (Rsk1, 2, 3 and 4) was performed at various stages of odontogenesis in wild-type (WT) mice. Rsk2 is expressed in the mesenchymal, neural crest-derived compartment, correlating with proliferative areas of the developing teeth. This is consistent with RSK2 functioning in cell cycle control and growth regulation, functions potentially responsible for severe dental phenotypes. To uncover molecular pathways involved in the etiology of these defects, we performed a comparative transcriptomic (DNA microarray) analysis of mandibular wild-type versus Rsk2-/Y molars. We further demonstrated a misregulation of several critical genes, using a Rsk2 shRNA knock-down strategy in molar tooth germs cultured in vitro. This study reveals RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets.

  17. RSK2 is a modulator of craniofacial development.

    Directory of Open Access Journals (Sweden)

    Virginie Laugel-Haushalter

    Full Text Available BACKGROUND: The RSK2 gene is responsible for Coffin-Lowry syndrome, an X-linked dominant genetic disorder causing mental retardation, skeletal growth delays, with craniofacial and digital abnormalities typically associated with this syndrome. Craniofacial and dental anomalies encountered in this rare disease have been poorly characterized. METHODOLOGY/PRINCIPAL FINDINGS: We examined, using X-Ray microtomographic analysis, the variable craniofacial dysmorphism and dental anomalies present in Rsk2 knockout mice, a model of Coffin-Lowry syndrome, as well as in triple Rsk1,2,3 knockout mutants. We report Rsk mutation produces surpernumerary teeth midline/mesial to the first molar. This highly penetrant phenotype recapitulates more ancestral tooth structures lost with evolution. Most likely this leads to a reduction of the maxillary diastema. Abnormalities of molar shape were generally restricted to the mesial part of both upper and lower first molars (M1. Expression analysis of the four Rsk genes (Rsk1, 2, 3 and 4 was performed at various stages of odontogenesis in wild-type (WT mice. Rsk2 is expressed in the mesenchymal, neural crest-derived compartment, correlating with proliferative areas of the developing teeth. This is consistent with RSK2 functioning in cell cycle control and growth regulation, functions potentially responsible for severe dental phenotypes. To uncover molecular pathways involved in the etiology of these defects, we performed a comparative transcriptomic (DNA microarray analysis of mandibular wild-type versus Rsk2-/Y molars. We further demonstrated a misregulation of several critical genes, using a Rsk2 shRNA knock-down strategy in molar tooth germs cultured in vitro. CONCLUSIONS: This study reveals RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets.

  18. RSK2 Is a Modulator of Craniofacial Development

    Science.gov (United States)

    Laugel-Haushalter, Virginie; Paschaki, Marie; Marangoni, Pauline; Pilgram, Coralie; Langer, Arnaud; Kuntz, Thibaut; Demassue, Julie; Morkmued, Supawich; Choquet, Philippe; Constantinesco, André; Bornert, Fabien; Schmittbuhl, Matthieu; Pannetier, Solange; Viriot, Laurent; Hanauer, André; Dollé, Pascal; Bloch-Zupan, Agnès

    2014-01-01

    Background The RSK2 gene is responsible for Coffin-Lowry syndrome, an X-linked dominant genetic disorder causing mental retardation, skeletal growth delays, with craniofacial and digital abnormalities typically associated with this syndrome. Craniofacial and dental anomalies encountered in this rare disease have been poorly characterized. Methodology/Principal Findings We examined, using X-Ray microtomographic analysis, the variable craniofacial dysmorphism and dental anomalies present in Rsk2 knockout mice, a model of Coffin-Lowry syndrome, as well as in triple Rsk1,2,3 knockout mutants. We report Rsk mutation produces surpernumerary teeth midline/mesial to the first molar. This highly penetrant phenotype recapitulates more ancestral tooth structures lost with evolution. Most likely this leads to a reduction of the maxillary diastema. Abnormalities of molar shape were generally restricted to the mesial part of both upper and lower first molars (M1). Expression analysis of the four Rsk genes (Rsk1, 2, 3 and 4) was performed at various stages of odontogenesis in wild-type (WT) mice. Rsk2 is expressed in the mesenchymal, neural crest-derived compartment, correlating with proliferative areas of the developing teeth. This is consistent with RSK2 functioning in cell cycle control and growth regulation, functions potentially responsible for severe dental phenotypes. To uncover molecular pathways involved in the etiology of these defects, we performed a comparative transcriptomic (DNA microarray) analysis of mandibular wild-type versus Rsk2-/Y molars. We further demonstrated a misregulation of several critical genes, using a Rsk2 shRNA knock-down strategy in molar tooth germs cultured in vitro. Conclusions This study reveals RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets. PMID:24416220

  19. ICRF array module development and optimization for high power density

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, P.M.; Swain, D.W.

    1997-02-01

    This report describes the analysis and optimization of the proposed International Thermonuclear Experimental Reactor (ITER) Antenna Array for the ion cyclotron range of frequencies (ICRF). The objectives of this effort were to: (1) minimize the applied radiofrequency rf voltages occurring in vacuum by proper layout and shape of components, limit the component`s surface/volumes where the rf voltage is high; (2) study the effects of magnetic insulation, as applied to the current design; (3) provide electrical characteristics of the antenna for the development and analysis of tuning, arc detection/suppression, and systems for discriminating between arcs and edge-localized modes (ELMs); (4) maintain close interface with mechanical design.

  20. Development and investigation of a CPV module with Cassegrain mirror optics

    Science.gov (United States)

    Dreger, Max; Wiesenfarth, Maike; Kisser, Arne; Schmid, Tobias; Bett, Andreas W.

    2014-09-01

    One approach to concentrate the sunlight in concentrating photovoltaic (CPV) modules is using Cassegrain mirror optics. The advantage is that a passively cooled solar cell can be mounted to a large heat spreader that does not shade the primary optics. In addition, the height of the module, hence weight, can be low. The design was selected on the basis of the results of a design study comparing different CPV module approaches presented in [1]. In this work, we present the development of a new prototype micro dish module. First results of the characterization are shown. Besides of the electrical performance, a machined optics and an injection molded was investigated regarding sensitivity to misalignment errors between the optical elements as well as measurement of the acceptance angle in- and outdoors. The machined optics was used as reference.

  1. Host microbiota modulates development of social preference in mice

    Directory of Open Access Journals (Sweden)

    Tim Arentsen

    2015-12-01

    Full Text Available Background: Mounting evidence indicates that the indigenous gut microbiota exerts long-lasting programming effects on brain function and behaviour. Objective: In this study, we used the germ-free (GF mouse model, devoid of any microbiota throughout development, to assess the influence of the indigenous microbiota on social preference and repetitive behaviours (e.g. self-grooming. Methods and results: Using the three-chambered social approach task, we demonstrate that when adult GF mice were given a choice to spend time with a novel mouse or object, they spent significantly more time sniffing and interacting with the stimulus mouse compared to conventionally raised mice (specific pathogen-free, SPF. Time spent in repetitive self-grooming behaviour, however, did not differ between GF and SPF mice. Real-time PCR–based gene expression analysis of the amygdala, a key region that is part of the social brain network, revealed a significant reduction in the mRNA levels of total brain-derived neurotrophic factor (BDNF, BDNF exon I-, IV-, VI-, IX-containing transcripts, and NGFI-A (a signalling molecule downstream of BDNF in GF mice compared to SPF mice. Conclusion: These results suggest that differential regulation of BDNF exon transcripts in the amygdala by the indigenous microbes may contribute to the altered social development of GF mice.

  2. Twenty Practices of an Entrepreneurial University

    DEFF Research Database (Denmark)

    Gjerding, Allan Næs; Wilderom, Celeste P.M.; Cameron, Shona P.B.;

    2006-01-01

    similarities; especially that entrepreneurship within universities has to be welcomed and facilitated top-down, but organically occurs and develops bottom-up. Implementing entrepreneurship at universities is thus about stimulating a culture of organic intrapreneurship and we provide practical recommendations...... studies twenty organisational practices against which a University's entrepreneurship can be measured. These twenty practices or factors in effect formed the basis for an entrepreneurship audit. During a series of interviews, the extent to which the universities are seen as entrepreneurial...... by the interviewees was surveyed. We showed that the practices have been implemented only to various degrees and rather unsystematically. There are important differences among the universities, to some extent depending on the level of ambition that each university has regarding each practice. There are also important...

  3. Cost effective second generation AC-modules: Development and testing aspects

    Energy Technology Data Exchange (ETDEWEB)

    Islam, Saiful; Belmans, Ronnie [Katholieke Universiteit Leuven, Department of Electrical Engineering, ESAT/ELECTA, Kasteelpark Arenberg 10, B-3001 Leuven-Heverlee (Belgium); Woyte, Achim [3E nv, Verenigingsstraat 39, B-1000, Brussel (Belgium); Heskes, Peter; Rooij, P.M. [Energy Research Centre of the Netherlands ECN, PO Box 1, 1755 ZG Petten (Netherlands); Hogedoorn, Ron [Mastervolt International, Snijdersbergweg 93, 1105AN Amsterdam Z.O. (Netherlands)

    2006-09-15

    In the framework of the European research project PV2GO, a new AC-module inverter was developed, taking into account all relevant aspects from a European market's point of view (standards, market, application, and research and development goals). The project goal was to achieve the overall system costs of 3 Euro per Wp for a modular plug-and-play photovoltaic system. For the photovoltaic-module, a standard 130-Wp Eurosolare module was chosen. The research and development (R and D) goal was to develop an advanced DC-control system consisting of a state-of-the-art programmable digital device and an Application Specific Integrated Circuit (ASIC) for the AC-control of the inverter. According to the topology concept, thermal and magnetic designs were optimized with regard to production technology and packaging for large-scale production. The new AC-modules were tested in a number of field-test sites in various parts of Europe and their reliability was assessed through Highly Accelerated Stress Tests. Efficiency and power quality have been tested in the laboratory. Further in the PV2GO project an optimization study of the manufacturing process of the new generation of AC-modules for high volume output was done. Another task was the pre-certification procedure to assure compliance with the European guidelines and standards. (author)

  4. DEVELOPMENT OF A LOW COST INFERENTIAL NATURAL GAS ENERGY FLOW RATE PROTOTYPE RETROFIT MODULE

    Energy Technology Data Exchange (ETDEWEB)

    E. Kelner; D. George; T. Morrow; T. Owen; M. Nored; R. Burkey; A. Minachi

    2005-05-01

    In 1998, Southwest Research Institute began a multi-year project to develop a working prototype instrument module for natural gas energy measurement. The module will be used to retrofit a natural gas custody transfer flow meter for energy measurement, at a cost an order of magnitude lower than a gas chromatograph. Development and evaluation of the prototype energy meter in 2002-2003 included: (1) refinement of the algorithm used to infer properties of the natural gas stream, such as heating value; (2) evaluation of potential sensing technologies for nitrogen content, improvements in carbon dioxide measurements, and improvements in ultrasonic measurement technology and signal processing for improved speed of sound measurements; (3) design, fabrication and testing of a new prototype energy meter module incorporating these algorithm and sensor refinements; and (4) laboratory and field performance tests of the original and modified energy meter modules. Field tests of the original energy meter module have provided results in close agreement with an onsite gas chromatograph. The original algorithm has also been tested at a field site as a stand-alone application using measurements from in situ instruments, and has demonstrated its usefulness as a diagnostic tool. The algorithm has been revised to use measurement technologies existing in the module to measure the gas stream at multiple states and infer nitrogen content. The instrumentation module has also been modified to incorporate recent improvements in CO{sub 2} and sound speed sensing technology. Laboratory testing of the upgraded module has identified additional testing needed to attain the target accuracy in sound speed measurements and heating value.

  5. Development of second generation peptides modulating cellular adiponectin receptor responses

    Science.gov (United States)

    Otvos, Laszlo; Knappe, Daniel; Hoffmann, Ralf; Kovalszky, Ilona; Olah, Julia; Hewitson, Tim; Stawikowska, Roma; Stawikowski, Maciej; Cudic, Predrag; Lin, Feng; Wade, John; Surmacz, Eva; Lovas, Sandor

    2014-10-01

    The adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines, including adiponectin. Recently we developed and characterized a first-in-class peptide-based adiponectin receptor agonist by using in vitro and in vivo models of glioblastoma and breast cancer (BC). In the current study, we further explored the effects of peptide ADP355 in additional cellular models and found that ADP355 inhibited chronic myeloid leukemia (CML) cell proliferation and renal myofibroblast differentiation with mid-nanomolar IC50 values. According to molecular modeling calculations, ADP355 was remarkably flexible in the global minimum with a turn present in the middle of the peptide. Considering these structural features of ADP355 and the fact that adiponectin normally circulates as multimeric complexes, we developed and tested the activity of a linear branched dimer (ADP399). The dimer exhibited approximately 20-fold improved cellular activity inhibiting K562 CML and MCF-7 cell growth with high pM - low nM relative IC50 values. Biodistribution studies suggested superior tissue dissemination of both peptides after subcutaneous administration relative to intraperitoneal inoculation. After screening of a 397-member adiponectin active site library, a novel octapeptide (ADP400) was designed that counteracted 10-1000 nM ADP355- and ADP399-mediated effects on CML and BC cell growth at nanomolar concentrations. ADP400 induced mitogenic effects in MCF-7 BC cells perhaps due to antagonizing endogenous adiponectin actions or acting as an inverse agonist. While the linear dimer agonist ADP399 meets pharmacological criteria of a contemporary peptide drug lead, the peptide showing antagonist activity (ADP400) at similar concentrations will be an important target validation tool to study adiponectin functions.

  6. Development of second generation peptides modulating cellular adiponectin receptor responses

    Directory of Open Access Journals (Sweden)

    Laszlo eOtvos

    2014-10-01

    Full Text Available The adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines, including adiponectin. Recently we developed and characterized a first-in-class peptide-based adiponectin receptor agonist by using in vitro and in vivo models of glioblastoma and breast cancer (BC. In the current study, we further explored the effects of peptide ADP355 in additional cellular models and found that ADP355 inhibited chronic myeloid leukemia (CML cell proliferation and renal myofibroblast differentiation with mid-nanomolar IC50 values. According to molecular modeling calculations, ADP355 was remarkably flexible in the global minimum with a turn present in the middle of the peptide. Considering these structural features of ADP355 and the fact that adiponectin normally circulates as multimeric complexes, we developed and tested the activity of a linear branched dimer (ADP399. The dimer exhibited approximately 20-fold improved cellular activity inhibiting K562 CML and MCF-7 cell growth with high pM - low nM relative IC50 values. Biodistribution studies suggested superior tissue dissemination of both peptides after subcutaneous administration relative to intraperitoneal inoculation. After screening of a 397-member adiponectin active site library, a novel octapeptide (ADP400 was designed that counteracted 10-1000 nM ADP355- and ADP399-mediated effects on CML and BC cell growth at nanomolar concentrations. ADP400 induced mitogenic effects in MCF-7 BC cells perhaps due to antagonizing endogenous adiponectin actions or acting as an inverse agonist. While the linear dimer agonist ADP399 meets pharmacological criteria of a contemporary peptide drug lead, the peptide showing antagonist activity (ADP400 at similar concentrations will be an important target validation tool to study adiponectin functions.

  7. Twenty-first century learning in afterschool.

    Science.gov (United States)

    Schwarz, Eric; Stolow, David

    2006-01-01

    Twenty-first century skills increasingly represent the ticket to the middle class. Yet, the authors argue, in-school learning is simply not enough to help students develop these skills. The authors make the case that after-school (or out-of-school) learning programs are emerging as one of the nation's most promising strategies for preparing young people for the workforce and civic life. Most school systems have significant limitations for teaching twenty-first century skills. They have the limits of time: with only six hours per day there is barely enough time to teach even the basic skills, especially for those students starting already behind. They have the limits of structure: typical school buildings and classrooms are not physically set up for innovative learning. They have the limits of inertia and bureaucracy: school systems are notoriously resistant to change. And perhaps most important, they have the limits of priorities: especially with the onset of the No Child Left Behind Act, schools are laserlike in their focus on teaching the basics and therefore have less incentive to incorporate twenty-first century skills. Meanwhile, the authors argue that after-school programs are an untapped resource with three competitive advantages. First, they enable students to work collaboratively in small groups, a setup on which the modern economy will increasingly rely. Second, they are well suited to project-based learning and the development of mastery. Third, they allow students to learn in the real-world contexts that make sense. Yet the after-school sector is fraught with challenges. It lacks focus-Is it child care, public safety, homework tutoring? And it lacks rigorous results. The authors argue that the teaching of twenty-first century skills should become the new organizing principle for afterschool that will propel the field forward and more effectively bridge in-school and out-of-school learning.

  8. Module and Electronics Developments for the ATLAS ITK Pixel System

    CERN Document Server

    Nellist, Clara; The ATLAS collaboration

    2016-01-01

    ATLAS is preparing for an extensive modification of its detector in the course of the planned HL-LHC accelerator upgrade around 2025 which includes a replacement of the entire tracking system by an all-silicon detector (Inner Tracker, ITk). The five innermost layers of ITk will comprise of a pixel detector built of new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m$^{2}$, depending on the final layout choice that is expected to take place in early 2017. An intense R\\&D activity is taking place in the field of planar, 3D, CMOS sensors to identify the optimal technology for the different pixel layers. In parallel various sensor-chip interconnection options are explored to identify reliable technologies when employing 100-150~$\\mu$m thin chips. While the new read-out chip is being developed by the RD53 Collaboration, the pixel off de...

  9. Light and gravity signals synergize in modulating plant development

    Science.gov (United States)

    Vandenbrink, Joshua P.; Kiss, John Z.; Herranz, Raul; Medina, F. Javier

    2014-01-01

    Tropisms are growth-mediated plant movements that help plants to respond to changes in environmental stimuli. The availability of water and light, as well as the presence of a constant gravity vector, are all environmental stimuli that plants sense and respond to via directed growth movements (tropisms). The plant response to gravity (gravitropism) and the response to unidirectional light (phototropism) have long been shown to be interconnected growth phenomena. Here, we discuss the similarities in these two processes, as well as the known molecular mechanisms behind the tropistic responses. We also highlight research done in a microgravity environment in order to decouple two tropisms through experiments carried out in the absence of a significant unilateral gravity vector. In addition, alteration of gravity, especially the microgravity environment, and light irradiation produce important effects on meristematic cells, the undifferentiated, highly proliferating, totipotent cells which sustain plant development. Microgravity produces the disruption of meristematic competence, i.e., the decoupling of cell proliferation and cell growth, affecting the regulation of the cell cycle and ribosome biogenesis. Light irradiation, especially red light, mediated by phytochromes, has an activating effect on these processes. Phytohormones, particularly auxin, also are key mediators in these alterations. Upcoming experiments on the International Space Station will clarify some of the mechanisms and molecular players of the plant responses to these environmental signals involved in tropisms and the cell cycle. PMID:25389428

  10. Light and gravity signals synergize in modulating plant development

    Directory of Open Access Journals (Sweden)

    Joshua P. Vandenbrink

    2014-10-01

    Full Text Available Tropisms are growth-mediated plant movements that help plants to respond to changes in environmental stimuli. The availability of water and light, as well as the presence of a constant gravity vector, are all environmental stimuli that plants sense and respond to via directed growth movements (tropisms. The plant response to gravity (gravitropism and the response to unidirectional light (phototropism have long been shown to be interconnected growth phenomena. Here, we discuss the similarities in these two processes, as well as the known molecular mechanisms behind the tropistic responses. We also highlight experiments done in a microgravity environment in order to decouple two tropisms through experiments carried out in the absence of a significant unilateral gravity vector. In addition, alteration of gravity, especially the microgravity environment, and light irradiation produce important effects on meristematic cells, the undifferentiated, highly proliferating, totipotent cells which sustain plant development. Microgravity produces the disruption of meristematic competence, i.e. the decoupling of cell proliferation and cell growth, affecting the regulation of cell cycle and ribosome biogenesis. Light irradiation, especially red light, mediated by phytochromes, has an activating effect on these processes. Phytohormones, particularly auxin, are key mediators in these alterations. Upcoming experiments on the International Space Station will clarify some of the unknown mechanisms and molecular players of the plant responses to these environmental signals involved in tropisms and the cell cycle.

  11. Module and Electronics Developments for the ATLAS ITK Pixel System

    CERN Document Server

    Rummler, Andr{e}; The ATLAS collaboration

    2016-01-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase II shutdown around 2025 by an all-silicon detector (Inner Tracker, ITk). The pixel detector will be composed by the five innermost layers, instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the severe HL-LHC environment in terms of occupancy and radiation. The total area of the new pixel system could measure up to 14 m^2, depending on the final layout choice that is expected to take place in early 2017. Different designs of planar, 3D, CMOS sensors are being investigated to identify the optimal technology for the different pixel layers. In parallel sensor-chip interconnection options are evaluated in collaboration with industrial partners to identify reliable technologies when employing 100-150 μm thin chips. While the new read-out chip is being developed by the RD53 Collaboration, the pixel off detector read-out electronics will be implemented in the frame...

  12. Recent developments in antiandrogens and selective androgen receptor modulators.

    Science.gov (United States)

    Haendler, Bernard; Cleve, Arwed

    2012-04-16

    The androgens testosterone and dihydrotestosterone play an essential role in the development and maintenance of primary and secondary male characteristics. Androgens bind to a specific androgen receptor (AR), a ligand-dependent transcription factor which controls the expression of a large number of downstream target genes. The AR is an essential player in early and late prostate cancer, and may also be involved in some forms of breast cancer. It also represents a drug target for the treatment of hypogonadism. Recent studies furthermore indicate that targeting the AR in pathologies such as frailty syndrome, cachexia or polycystic ovary syndrome may have clinical benefit. Numerous AR ligands with very different pharmacological properties have been identified in the last 40 years and helped to treat several of these diseases. However, progress still needs to be made in order to find compounds with an improved profile with regard to efficacy, differentiation and side-effects. This will only be achieved through a better understanding of the mechanisms involved in normal and aberrant AR signaling.

  13. Development of a 3D pixel module for an ultralarge screen 3D display

    Science.gov (United States)

    Hashiba, Toshihiko; Takaki, Yasuhiro

    2004-10-01

    A large screen 2D display used at stadiums and theaters consists of a number of pixel modules. The pixel module usually consists of 8x8 or 16x16 LED pixels. In this study we develop a 3D pixel module in order to construct a large screen 3D display which is glass-free and has the motion parallax. This configuration for a large screen 3D display dramatically reduces the complexity of wiring 3D pixels. The 3D pixel module consists of several LCD panels, several cylindrical lenses, and one small PC. The LCD panels are slanted in order to differentiate the distances from same color pixels to the axis of the cylindrical lens so that the rays from the same color pixels are refracted into the different horizontal directions by the cylindrical lens. We constructed a prototype 3D pixel module, which consists of 8x4 3D pixels. The prototype module is designed to display 300 different patterns into different horizontal directions with the horizontal display angle pitch of 0.099 degree. The LCD panels are controlled by a small PC and the 3D image data is transmitted through the Gigabit Ethernet.

  14. Development and testing of shingle-type solar cell modules. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, N.F.

    1979-02-28

    The design, development, fabrication and testing of a shingle-type terrestrial solar cell module which produces 98 watts/m/sup 2/ of exposed module area at 1 kW/m/sup 2/ insolation and 61/sup 0/C are reported. These modules make it possible to easily incorporate photovoltaic power generation into the sloping roofs of residential or commercial buildings by simply nailing the modules to the plywood roof sheathing. This design consists of nineteen series-connected 53 mm diameter solar cells arranged in a closely packaged hexagon configuration. These cells are individually bonded to the embossed surface of a 3 mm thick thermally tempered hexagon-shaped piece of ASG SUNADEX glass. Monsanto SAFLEX polyvinyl butyral is used as the laminating adhesive. RTVII functions as the encapsulant between the underside of the glass superstrate and a rear protective sheet of 0.8 mm thick TEXTOLITE. The semi-flexible portion of each shingle module is a composite laminate construction consisting of outer layers of B.F. Goodrich FLEXSEAL and an epichlorohydrin closed cell foam core. The module design has satisfactorily survived the JPL-defined qualification testing program which includes 50 thermal cycles between -40 and +90/sup 0/C, a seven-day temperature-humidity exposure test and a mechanical integrity test consisting of a bidirectional cyclic loading at 2390 Pa (50 lb/ft/sup 2/) which is intended to simulate loads due to a 45 m/s (100 mph) wind.

  15. Development and fabrication of photovoltaic concentrator modules for a point-focus Fresnel lens array

    Energy Technology Data Exchange (ETDEWEB)

    Broadbent, S.; Sanders, J.A.

    1985-06-01

    Design of the second generation photovoltaic concentrator module originally developed by Martin Marietta under Contract 46-3018 was improved. Module efficiency was improved from 14.4% to 15.5% and numerous detailed design enhancements were incorporated to facilitate fabrication and improve cost effectiveness. Sixty modules were manufactured to populate the second generation structure already installed at the Sandia National Laboratories test site in Albuquerque, NM, plus 10 spares and test units. To further improve the life capability and facilitate installation of the design, additional design development was authorized for (1) cell interconnect research to provide greater stress relief at the cell-interconncet and substrate-interconnect interfaces; and (2) incorporation of a reflective secondary to relieve tracking accuracy and initial alignment accuracy requirements.

  16. Preliminary development and evaluation of online tobacco and alcohol modules for dental students.

    Science.gov (United States)

    Miller, Peter M; Heideman, Paul W; Ravenel, Michele C; Spangler, John G; Mauldin, Mary P; Hill, Elizabeth G; Onicescu, Georgiana

    2011-06-01

    Tobacco use and heavy alcohol consumption are major risk factors for the development of oral and pharyngeal cancer (OPC). Detection and modification of these risks by dentists are keys in preventing OPC. While dentists are encouraged to screen patients for tobacco and alcohol use and educate them about the oral health risks they pose, dental students receive little formalized training in this area. This pilot project was designed to develop and evaluate two online training modules for dental students: one on tobacco and oral health risk factors, and one on methods of alcohol screening. Results indicated that online tobacco/alcohol education for dental students is feasible. The modules resulted in meaningful improvement in dental students' knowledge of tobacco and alcohol use as well as alcohol screening methods. The alcohol module resulted in statistically significant increases in intention to screen patients for alcohol use and in comfort level in performing alcohol screening.

  17. [Role of androgen in the elderly. Current status of development of selective androgen receptor modulator].

    Science.gov (United States)

    Yanase, Toshihiko

    2013-08-01

    The research to develop a drug, so called selective androgen receptor modulator (SARM) , which shows beneficial androgenic action on bone and muscle, but hardly possesses the stimulatory action on prostate has been making a progress. However, no drug is available in the market at present. Most of such drugs are developed, aiming at the application to age-related muscle reduction (sarcopenia) and osteoporosis. We are now trying to develop a SARM which may have beneficial effect on metabolic syndrome.

  18. A Survey of Hardware and Software Technologies for the Rapid Development of Multimedia Instructional Modules

    Science.gov (United States)

    Ganesan, Nanda

    2008-01-01

    A survey of hardware and software technologies was conducted to identify suitable technologies for the development of instructional modules representing various instructional approaches. The approaches modeled were short PowerPoint presentations, chalk-and-talk type of lectures and software tutorials. The survey focused on identifying application…

  19. "Scaffolding" of Action Learning within a Part-Time Management Development Module

    Science.gov (United States)

    Joesbury, Mark

    2015-01-01

    This Account of Practice describes the introduction and development of action learning within a level 5 module of "Communications at Work" delivered as part of a Business & Technology Education Council (BTEC) Professional Certificate in Management (CMS) between 2005/2006 and 2009/2010. This will commence with a personal narrative and…

  20. Development and Implementation of High School Chemistry Modules Using Touch-Screen Technologies

    Science.gov (United States)

    Lewis, Maurica S.; Zhao, Jinhui; Montclare, Jin Kim

    2012-01-01

    Technology was employed to motivate and captivate students while enriching their in-class education. An outreach program is described that involved college mentors introducing touch-screen technology into a high school chemistry classroom. Three modules were developed, with two of them specifically tailored to encourage comprehension of molecular…

  1. Design and development of a semi-automated module for the preparation of metallic PET radionuclides

    Science.gov (United States)

    Trejo-Ballado, F.; Lopez-Rodriguez, V.; Gaspar-Carcamo, R. E.; Hurtado-Chong, G.; Avila-Rodriguez, Miguel A.

    2012-12-01

    The method for the production of metallic radionuclides has been widely reported, and most of them share a common ion chromatography purification technique. The aim of this work is to design and develop a semi-automated remotely controlled module for the purification of metallic PET radionuclides via cation exchange chromatography.

  2. Evaluation of clinical teaching and professional development in a problem and community-based nursing module

    Directory of Open Access Journals (Sweden)

    J.C de Villiers

    2004-09-01

    Full Text Available In South Africa the main focus is on primary health care. This affects the education and training of nurses, and training schools must respond by developing appropriate teaching modules. A school of nursing developed, implemented and revised a problem- and community- based learning module over a period of three years (1996-1998. This student-centered module focuses on students’ needs, active participation, collaboration, accountability, self-assessment, self-study, life-long learning and appropriate skills. In the formal clinical teaching environment PBL was the main approach. However, this approach was also supported by a variety of strategies, for example group discussions and scenarios. The knowledge, attitudes and professional development skills acquired in the PBL approach were then applied informally in the community setting (CBE. The purpose of the study was to evaluate a first year clinical teaching module as part of an extensive programme. A quantitative research method, a descriptive design, and a variety of data collection techniques were used. Conclusions were that clinical teaching was effective within the problem- (PBL and community-based (CBE approaches; 78% of respondents were positive about the clinical learning environment; 61 % stated that expectations were met; 81% preferred group activities, and 67% indicated that they had developed professional skills. Facilitators agreed that clinical teaching met the requirements of PBL & CBE. The pass rate also improved.

  3. Technique development of PC104 embedded module and its application in the geophysical instrument design

    Institute of Scientific and Technical Information of China (English)

    滕云田; 张炼; 王彦; 刘晓芹; 马延妮

    2002-01-01

    The mainstream embedded resolutions widely adopted in the geophysical observation device are discussed in this paper. The advantages and its applicability of the PC104 embedded module are demonstrated through its performance description, technique development and its applications in the design of the fluxgate magnetometer, the movable seismograph and the GPS steering device.

  4. A Survey of Hardware and Software Technologies for the Rapid Development of Multimedia Instructional Modules

    Science.gov (United States)

    Ganesan, Nanda

    2008-01-01

    A survey of hardware and software technologies was conducted to identify suitable technologies for the development of instructional modules representing various instructional approaches. The approaches modeled were short PowerPoint presentations, chalk-and-talk type of lectures and software tutorials. The survey focused on identifying application…

  5. Development and pilot testing of full-scale membrane distillation modules for deployment of waste heat

    NARCIS (Netherlands)

    Jansen, A.E.; Assink, J.W.; Hanemaaijer, J.H.; Medevoort, J. van; Sonsbeek, E. van

    2013-01-01

    Membrane distillation is an attractive technology for extracting fresh water from seawater. Newly developed modules have been used in pilot tests and bench scale tests to demonstrate the potential of producing excellent product water quality in a single step, little need for water pretreatment and a

  6. Development of a Web-Based 3D Module for Enhanced Neuroanatomy Education.

    Science.gov (United States)

    Allen, Lauren K; Ren, He Zhen; Eagleson, Roy; de Ribaupierre, Sandrine

    2016-01-01

    Neuroanatomy is a challenging subject, with novice medical students often experiencing difficulty grasping the intricate 3D spatial relationships. Most of the anatomical teaching in undergraduate medicine utilizes conventional 2D resources. E-learning technologies facilitate the development of learner-centered educational tools that can be tailored to meet each student's educational needs, and may foster improved learning in neuroanatomy, however this has yet to be examined fully in the literature. An interactive 3D e-learning module was developed to complement gross anatomy laboratory instruction. Incorporating such 3D modules may provide additional support for students in areas of anatomy that are spatially challenging, such as neuroanatomy. Specific anatomical structures and their relative spatial positions to other structures can be clearly defined in the 3D virtual environment from viewpoints that may not readily be available using cadaveric or 2D image modalities. Providing an interactive user interface for the 3D module in which the student controls many factors may enable the student to develop an improved understanding of the spatial relationships. This work outlines the process for the development of a 3D interactive module of the cerebral structures included in the anatomy curriculum for undergraduate medical students in their second year of study.

  7. Twenty-first century vaccines

    Science.gov (United States)

    Rappuoli, Rino

    2011-01-01

    In the twentieth century, vaccination has been possibly the greatest revolution in health. Together with hygiene and antibiotics, vaccination led to the elimination of many childhood infectious diseases and contributed to the increase in disability-free life expectancy that in Western societies rose from 50 to 78–85 years (Crimmins, E. M. & Finch, C. E. 2006 Proc. Natl Acad. Sci. USA 103, 498–503; Kirkwood, T. B. 2008 Nat. Med 10, 1177–1185). In the twenty-first century, vaccination will be expected to eliminate the remaining childhood infectious diseases, such as meningococcal meningitis, respiratory syncytial virus, group A streptococcus, and will address the health challenges of this century such as those associated with ageing, antibiotic resistance, emerging infectious diseases and poverty. However, for this to happen, we need to increase the public trust in vaccination so that vaccines can be perceived as the best insurance against most diseases across all ages. PMID:21893537

  8. Development of planar pixel modules for the ATLAS high luminosity LHC tracker upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Allport, P.P. [Department of Physics, University of Liverpool (United Kingdom); Ashby, J.; Bates, R.L.; Blue, A. [SUPA, School of Physics and Astronomy, University of Glasgow (United Kingdom); Burdin, S. [Department of Physics, University of Liverpool (United Kingdom); Buttar, C.M., E-mail: craig.buttar@glasgow.ac.uk [SUPA, School of Physics and Astronomy, University of Glasgow (United Kingdom); Casse, G.; Dervan, P. [Department of Physics, University of Liverpool (United Kingdom); Doonan, K. [SUPA, School of Physics and Astronomy, University of Glasgow (United Kingdom); Forshaw, D. [Department of Physics, University of Liverpool (United Kingdom); Lipp, J. [The Science and Technology Facilities Council, Rutherford Appleton Laboratory (United Kingdom); McMullen, T. [SUPA, School of Physics and Astronomy, University of Glasgow (United Kingdom); Pater, J. [School of Physics and Astronomy, University of Manchester (United Kingdom); Stewart, A. [SUPA, School of Physics and Astronomy, University of Glasgow (United Kingdom); Tsurin, I. [Department of Physics, University of Liverpool (United Kingdom)

    2014-11-21

    The high-luminosity LHC will present significant challenges for tracking systems. ATLAS is preparing to upgrade the entire tracking system, which will include a significantly larger pixel detector. This paper reports on the development of large area planar detectors for the outer pixel layers and the pixel endcaps. Large area sensors have been fabricated and mounted onto 4 FE-I4 readout ASICs, the so-called quad-modules, and their performance evaluated in the laboratory and testbeam. Results from characterisation of sensors prior to assembly, experience with module assembly, including bump-bonding and results from laboratory and testbeam studies are presented.

  9. ATLAS pixel IBL modules construction experience and developments for future upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Gaudiello, A.

    2015-10-01

    The first upgrade of the ATLAS Pixel Detector is the Insertable B-Layer (IBL), installed in May 2014 in the core of ATLAS. Two different silicon sensor technologies, planar n-in-n and 3D, are used. Sensors are connected with the new generation 130 nm IBM CMOS FE-I4 read-out chip via solder bump-bonds. Production quality control tests were set up to verify and rate the performance of the modules before integration into staves. An overview of module design and construction, the quality control results and production yield will be discussed, as well as future developments foreseen for future detector upgrades.

  10. Development of Advanced Seed Laser Modules for Lidar and Spectroscopy Applications

    Science.gov (United States)

    Prasad, Narasimha S.; Rosiewicz, Alex; Coleman, Steven M.

    2013-01-01

    We report on recent progress made in the development of highly compact, single mode, distributed feedback laser (DFB) seed laser modules for lidar and spectroscopy applications from space based platforms. One of the intended application of this technology is in the NASA's Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission. The DFB laser modules operating at 1571 nm and 1262 nm have advanced current and temperature drivers built into them. A combination of temperature and current tuning allows coarse and fine adjustment of the diode wavelengths.

  11. Process development for automated solar cell and module production. Task 4: Automated array assembly

    Science.gov (United States)

    Hagerty, J. J.

    1981-01-01

    Progress in the development of automated solar cell and module production is reported. The unimate robot is programmed for the final 35 cell pattern to be used in the fabrication of the deliverable modules. The mechanical construction of the automated lamination station and final assembly station phases are completed and the first operational testing is underway. The final controlling program is written and optimized. The glass reinforced concrete (GRC) panels to be used for testing and deliverables are in production. Test routines are grouped together and defined to produce the final control program.

  12. Student-Centered Modules to Support Active Learning in Hydrology: Development Experiences and Users' Perspectives

    Science.gov (United States)

    Tarboton, D. G.; Habib, E. H.; Deshotel, M.; Merck, M. F.; Lall, U.; Farnham, D. J.

    2016-12-01

    Traditional approaches to undergraduate hydrology and water resource education are textbook based, adopt unit processes and rely on idealized examples of specific applications, rather than examining the contextual relations in the processes and the dynamics connecting climate and ecosystems. The overarching goal of this project is to address the needed paradigm shift in undergraduate education of engineering hydrology and water resources education to reflect parallel advances in hydrologic research and technology, mainly in the areas of new observational settings, data and modeling resources and web-based technologies. This study presents efforts to develop a set of learning modules that are case-based, data and simulation driven and delivered via a web user interface. The modules are based on real-world case studies from three regional hydrologic settings: Coastal Louisiana, Utah Rocky Mountains and Florida Everglades. These three systems provide unique learning opportunities on topics such as: regional-scale budget analysis, hydrologic effects of human and natural changes, flashflood protection, climate-hydrology teleconnections and water resource management scenarios. The technical design and contents of the modules aim to support students' ability for transforming their learning outcomes and skills to hydrologic systems other than those used by the specific activity. To promote active learning, the modules take students through a set of highly engaging learning activities that are based on analysis of hydrologic data and model simulations. The modules include user support in the form of feedback and self-assessment mechanisms that are integrated within the online modules. Module effectiveness is assessed through an improvement-focused evaluation model using a mixed-method research approach guiding collection and analysis of evaluation data. Both qualitative and quantitative data are collected through student learning data, product analysis, and staff interviews

  13. Assessing upper limb function in nonambulant SMA patients: development of a new module.

    Science.gov (United States)

    Mazzone, Elena; Bianco, Flaviana; Martinelli, Diego; Glanzman, Allan M; Messina, Sonia; De Sanctis, Roberto; Main, Marion; Eagle, Michelle; Florence, Julaine; Krosschell, Kristin; Vasco, Gessica; Pelliccioni, Marco; Lombardo, Marilena; Pane, Marika; Finkel, Richard; Muntoni, Francesco; Bertini, Enrico; Mercuri, Eugenio

    2011-06-01

    We report the development of a module specifically designed for assessing upper limb function in nonambulant SMA patients, including young children and those with severe contractures. The application of the module to a preschool cohort of 40 children (age 30-48 months) showed that all the items could be completed by 30 months. The module was also used in 45 nonambulant SMA patients (age 30 months to 27 years). Their scores were more variable than in the preschool cohort, ranging from 0 to 18. The magnitude of scores was not related to age (r=-0.19). The upper limb scores had a good correlation with the Hammersmith Functional Motor Scale, r=0.75, but the upper limb function did not always strictly follow the overall gross motor function. These findings suggest that even some of the very weak nonambulant children possess upper limb skills that can be measured.

  14. Development of a multi-PMT optical module prototype for PINGU

    Energy Technology Data Exchange (ETDEWEB)

    Classen, Lew [ECAP, University of Erlangen, Erwin-Rommel-Str. 1, Erlangen (Germany); Collaboration: IceCube-PINGU Collaboration

    2014-11-18

    The multi-PMT digital optical module (mDOM) contains 41 three-inch{sup 2} PMTs in a cylindrical glass vessel. The design is based on the KM3NeT DOM. Among other advantages, this approach offers a significant increase of photocathode area per module and also per string length. As an R and D activity targeted at potential future extensions, this new type of optical modules will be tested in the framework of the PINGU project (Precision IceCube Next Generation Upgrade). PINGU will add denser instrumentation to the IceCube/DeepCore sub-volume aiming at a further decrease of the neutrino energy threshold (to a few GeV). The current status of the development and the prototype construction is presented.

  15. Efficacy of a Meiosis Learning Module Developed for the Virtual Cell Animation Collection.

    Science.gov (United States)

    Goff, Eric E; Reindl, Katie M; Johnson, Christina; McClean, Phillip; Offerdahl, Erika G; Schroeder, Noah L; White, Alan R

    2017-01-01

    Recent reports calling for change in undergraduate biology education have resulted in the redesign of many introductory biology courses. Reports on one common change to course structure, the active-learning environment, have placed an emphasis on student preparation, noting that the positive outcomes of active learning in the classroom depend greatly on how well the student prepares before class. As a possible preparatory resource, we test the efficacy of a learning module developed for the Virtual Cell Animation Collection. This module presents the concepts of meiosis in an interactive, dynamic environment that has previously been shown to facilitate learning in introductory biology students. Participants (n = 534) were enrolled in an introductory biology course and were presented the concepts of meiosis in one of two treatments: the interactive-learning module or a traditional lecture session. Analysis of student achievement shows that students who viewed the learning module as their only means of conceptual presentation scored significantly higher (d = 0.40, p animation-based learning module effectively conveyed meiosis conceptual understanding, which suggests that it may facilitate student learning outside the classroom. Moreover, these results have implications for instructors seeking to expand their arsenal of tools for "flipping" undergraduate biology courses.

  16. Development of flame retardant PV module encapsulants: Volume 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Galica, J.P.

    1998-06-01

    This Phase 1 final report covers the work performed by Springborn Testing and Research, Inc., for the period October 1, 1997 to June 30, 1998 under the Department of Energy Cooperative Agreement Number DE-FC36-97GO10255, entitled Development of Flame Retardant PV Module Encapsulants. While use of roof-mounted arrays has always been an attractive means of deploying PV, only within recent years have such building integrated concepts (BIPV) found renewed interest among module makers and end-users. Prior to building integrated and rooftop applications, flammability requirements for modules have not been a great industry concern. However, with growing interest in BIPV and the requirement for building code requirements for commercial and industrial structures, flammability issues have become a barrier to entry for many module constructions into this potentially huge domestic market for PV. The overall goal of the 3 phase PV BONUS two project is to develop and commercialize a line of fire retardant encapsulation materials to serve the emerging building integrated and building mounted PV market. The objectives of the Phase 1 effort are limited to concept development and business planning activities.

  17. A community initiative for developing data and modeling driven curriculum modules for hydrology education

    Science.gov (United States)

    Ruddell, B. L.; Merwade, V.

    2010-12-01

    Hydrology and geoscience education at the undergraduate and graduate levels may benefit greatly from a structured approach to pedagogy that utilizes modeling, authentic data, and simulation exercises to engage students in practice-like activities. Extensive evidence in the educational literature suggests that students retain more of their instruction, and attain higher levels of mastery over content, when interactive and practice-like activities are used to contextualize traditional lecture-based and theory-based instruction. However, it is also important that these activities carefully link the use of data and modeling to abstract theory, to promote transfer of knowledge to other contexts. While this type of data-based activity has been practiced in the hydrology classroom for decades, the hydrology community still lacks a set of standards and a mechanism for community-based development, publication, and review of this type of curriculum material. A community-based initiative is underway to develop a set curriculum materials to teach hydrology in the engineering and geoscience university classroom using outcomes-based, pedagogically rigorous modules that use authentic data and modeling experiences to complement traditional lecture-based instruction. A preliminary design for a community cyberinfrastructure for shared module development and publication, and for module topics and outcomes and ametadata and module interoperability standards, will be presented, along with the results of a series of community surveys and workshops informing this design.

  18. Development of an e-Learning Research Module Using Multimedia Instruction Approach.

    Science.gov (United States)

    Kowitlawakul, Yanika; Chan, Moon Fai; Tan, Sharon Swee Lin; Soong, Alan Swee Kit; Chan, Sally Wai Chi

    2017-03-01

    Students nowadays feel more comfortable with new technologies, which increase their motivation and, as a result, improve their academic performance. In the last two decades, the use of information communication technology has been increasing in many disciplines in higher education. Online learning or e-learning has been used and integrated into the curriculum around the world. A team of nursing faculty and educational technology specialists have developed an e-learning research module and integrate it into the nursing curriculum. The aim was to assist master of nursing and postgraduate nursing students in developing their research knowledge before and throughout their enrollment in the research course. This e-learning module includes interactive multimedia such as audiovisual presentation, graphical theme, animation, case-based learning, and pretest and posttest for each topic area. The module focuses on three main topic areas: (1) basic research principles (for review), (2) quantitative method, and (3) qualitative method. The e-learning module is an innovative use of the information and communication technology to enhance student engagement and learning outcomes in a local context. This article discusses the development journey, piloting process, including the variety of evaluation perspectives, and the ways in which the results influenced the e-learning resource before its wider distribution.

  19. An expert-based landslide susceptibility mapping (LSM) module developed for Netcad Architect Software

    Science.gov (United States)

    Sezer, E. A.; Nefeslioglu, H. A.; Osna, T.

    2017-01-01

    The main purpose of this study is to introduce an expert-based LSM module developed for Netcad Architect Software. A landslide-prone area located at the eastern Black Sea region of Turkey was selected as the experimental site for this study. The investigations were performed in four stages: (i) introducing technical details of LSM module and theoretical background of the methods implemented in the module, (ii) experiments; landslide susceptibility evaluations by applying the methods M-AHP and Mamdani type FIS by using the expert-based LSM module, (iii) map similarity assessments and evaluations for the generalization capacities of the expert-based models, and (iv) performance assessments of the LSM module. When considering the areal distributions of matching ratios obtained from the map similarity evaluations, it is revealed that M-AHP is more pessimistic and covers a greater area in higher hazard classes, whereas the Mamdani type FIS behaves more optimistically and restricts the area of higher hazard classes in the experimental site. According to the Receiver Operating Characteristics (ROC) curve analyses, the value of Area Under the ROC Curve (AUC) was obtained as 0.66 for the resultant map produced with Mamdani type FIS and 0.82 for the map produced with M-AHP. To compare the time consumptions of the expert methods, experiments were implemented. Mamdani type FIS completes its task in 3 h and 39 min, whereas M-AHP only requires 47 s. As a consequence, (i) the LSM module developed for Netcad Architect Software presents full-featured expert-based landslide susceptibility mapping abilities, and (ii) M-AHP is a useful method for obtaining an expert opinion and modeling landslide susceptibility.

  20. Development and Impact Evaluation of an E-Learning Radiation Oncology Module

    Energy Technology Data Exchange (ETDEWEB)

    Alfieri, Joanne, E-mail: Joanne.alfieri@mail.mcgill.ca [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Portelance, Lorraine; Souhami, Luis [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Steinert, Yvonne; McLeod, Peter [Centre for Medical Education, McGill University, Montreal, QC (Canada); Gallant, Fleure [Department of Radiation Oncology, McGill University Health Centre, Montreal, QC (Canada); Artho, Giovanni [Department of Radiology, McGill University Health Centre, Montreal, QC (Canada)

    2012-03-01

    Purpose: Radiation oncologists are faced with the challenge of irradiating tumors to a curative dose while limiting toxicity to healthy surrounding tissues. This can be achieved only with superior knowledge of radiologic anatomy and treatment planning. Educational resources designed to meet these specific needs are lacking. A web-based interactive module designed to improve residents' knowledge and application of key anatomy concepts pertinent to radiotherapy treatment planning was developed, and its effectiveness was assessed. Methods and Materials: The module, based on gynecologic malignancies, was developed in collaboration with a multidisciplinary team of subject matter experts. Subsequently, a multi-centre randomized controlled study was conducted to test the module's effectiveness. Thirty-six radiation oncology residents participated in the study; 1920 were granted access to the module (intervention group), and 17 in the control group relied on traditional methods to acquire their knowledge. Pretests and posttests were administered to all participants. Statistical analysis was carried out using paired t test, analysis of variance, and post hoc tests. Results: The randomized control study revealed that the intervention group's pretest and posttest mean scores were 35% and 52%, respectively, and those of the control group were 37% and 42%, respectively. The mean improvement in test scores was 17% (p < 0.05) for the intervention group and 5% (p = not significant) for the control group. Retrospective pretest and posttest surveys showed a statistically significant change on all measured module objectives. Conclusions: The use of an interactive e-learning teaching module for radiation oncology is an effective method to improve the radiologic anatomy knowledge and treatment planning skills of radiation oncology residents.

  1. Kainate-type glutamate receptors modulating network activity in developing hippocampus

    OpenAIRE

    Juuri, Juuso

    2015-01-01

    Kainate-type of ionotropic glutamate (KA) receptors are associated with the modulation of neuronal excitability, synaptic transmission, and activity of neuronal networks. They are believed to have an important role in the development of neuronal connections. In this thesis, the role of KA receptors in the early brain development was assessed by conducting in vitro electrophysiological recordings from individual neurons at CA3 region in acute slices of neonatal rodent hippocampi. It was f...

  2. Curriculum Development of an ICT4D Module in the South African Context

    Directory of Open Access Journals (Sweden)

    Caroline Khene

    2015-06-01

    Full Text Available The significance of ICTs in supporting socio-economic development in developing countries is inevitable. As academics of information systems in developing countries, we cannot ignore the need for teaching and building the capacity of our students to become knowledgeable and skilled in Information and Communication Technology for Development (ICT4D practice and discourse. Furthermore, it is vital to equip our students with the ability to apply their discipline knowledge in addressing some of the ICT discrepancies in current ICT4D practice in their own context. I introduced and teach the ICT4D module to the Honours level course at my university in South Africa. This paper explores the factors that have influenced and shaped the development of the ICT4D module curriculum in the South African context I teach in, using a qualitative ethnographic lens and theoretical study. This provides a practice lens to motivate for and support the introduction of an ICT4D module in tertiary curricula in developing countries.

  3. Development of the Water Cooled Ceramic Breeder Test Blanket Module in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Enoeda, Mikio, E-mail: enoeda.mikio@jaea.go.jp [Japan Atomic Energy Agency, Naka-shi, Ibaraki-ken 311-0193 (Japan); Tanigawa, Hisashi; Hirose, Takanori; Suzuki, Satoshi; Ochiai, Kentaro; Konno, Chikara; Kawamura, Yoshinori; Yamanishi, Toshihiko; Hoshino, Tsuyoshi; Nakamichi, Masaru; Tanigawa, Hiroyasu; Ezato, Koichiro; Seki, Yohji; Yoshikawa, Akira; Tsuru, Daigo; Akiba, Masato [Japan Atomic Energy Agency, Naka-shi, Ibaraki-ken 311-0193 (Japan)

    2012-08-15

    The development of a Water Cooled Ceramic Breeder (WCCB) Test Blanket Module (TBM) is being performed as one of the most important steps toward DEMO blanket in Japan. For the TBM testing and evaluation toward DEMO blanket, the module fabrication technology development by a candidate structural material, reduced activation martensitic/ferritic steel, F82H, is one of the most critical items from the viewpoint of realization of TBM testing in ITER. In Japan, fabrication of a real scale first wall, side walls, a breeder pebble bed box and assembling of the first wall and side walls have succeeded. Recently, the real scale partial mockup of the back wall was fabricated. The fabrication procedure of the back wall, whose thickness is up to 90 mm, was confirmed toward the fabrication of the real scale back wall by F82H. Important key technologies are almost clarified for the fabrication of the real scale TBM module mockup. From the view point of testing and evaluation, development of the technology of the blanket tritium recovery, development of advanced breeder and multiplier pebbles and the development of the blanket neutronics measurement technology are also performed. Also, tritium production and recovery test using D-T neutron in the Fusion Neutronics Source (FNS) facility has been started as the verification test of tritium production performance. This paper overviews the recent achievements of the development of the WCCB TBM in Japan.

  4. Development of MATLAB-Based Digital Signal Processing Teaching Module with Graphical User Interface Environment for Nigerian University

    OpenAIRE

    2013-01-01

    The development of a teaching aid module for digital Signal processing (DSP) in Nigeria Universities was undertaken to address the problem associated with non-availability instructional module. This paper annexes the potential of Peripheral Interface Controllers (PICs) with MATLAB resources to develop a PIC-based system with graphic user interface environment suitable for data acquisition and signal processing. The module accepts data from three different sources: real time acquisition, pre-r...

  5. Design and development of a prototype 25 kV, 10 A long pulse Marx modulator for high power klystron

    Science.gov (United States)

    Acharya, Mahesh; Shrivastava, Purushottam

    2016-02-01

    Research, design, and development of high average power modulators for the proposed Indian Spallation Neutron Source are in progress at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of 25 kV, 10 A, 1 ms Marx modulator at repetition rate of 1 Hz has been designed and developed which serves as a proof of principle and technology assessment stage for further development of high repetition rate high voltage high average power modulators. Insulated Gate Bipolar Transistor (IGBT) based modules of 2.8 kV switching capability have been used as main modules. The modulator had 8.2% droop in output voltage pulse without any droop compensation circuit. A droop compensation involving 15 corrector modules has been used to reduce the droop up to 1%. We have used IGBT based 250 V switches to realize the corrector module. A microcontroller based control unit was designed and developed for triggering the main and corrector modules. With this control unit, programmable output pulse has been achieved. Electrical isolation between high voltage circuits and control circuit has been achieved by the use of fiber optic based control signal transmission. Output pulses of 1 ms pulse width, 800 ns rise time, and 5 μs fall time have been achieved. The modulator has advantages of modular design, adjustable pulse width, adjustable rise time, and fall time.

  6. Effects of nitric oxide modulating activities on development of enteric nervous system mediated gut motility in chick embryo model

    Indian Academy of Sciences (India)

    Hossein-Ali Arab; Samad Muhammadnejad; Seyed-Muhammad Faghihi; Hossein Hassanpour; Ahad Muhammadnejad

    2014-12-01

    The enteric nervous system (ENS) arises from the enteric neural crest-derived cells (ENCCs), and many molecules and biochemical processes may be involved in its development. This study examined the effects of modulating embryonic nitric oxide (NO) activity on the intestinal motility induced by ENS. One-hundred-and-twenty fertilized chicken eggs were assigned to three main groups and incubated at 37°C and 60% humidity. The eggs were treated with -nitro-L-arginine methyl ester (L-NAME), sodium nitroprusside (SNP), L-arginine (L-Arg) or vehicle from days 3 (1st group), 7 (2nd group) and 10 (3rd group) of incubation and continued up to day 18. On day 19, the embryos were sacrificed, the jejunal and colorectal segments were taken and the intestinal motility was assessed using isolated organ system. The intestinal motility was recorded normally and following cholinergic, adrenergic and non-adrenergic non-cholinergic (NANC) stimulations. The ENS structure was assessed by immunohistochemistry (IHC) using glial fibrillary acidic protein (GFAP). Rhythmic intestinal contractions were seen in all treatment groups, but inhibition of NO in the L-NAME-treated embryos caused significant decrease ( < 0.01) in the frequency and amplitude of the contraction. The responsiveness to adrenergic, cholinergic and NANC stimulations was also significantly decreased ( <0.05). The GFAP expression was significantly ( < 0.05) reduced in the L-NAME-treated embryos. This study showed that the inhibition of NO caused a deficient development of the ENS, leading to a decrease in the frequency and amplitude of the intestinal contractions and reduced the responsiveness to adrenergic, cholinergic and NANC signalling.

  7. Process development for automated solar cell and module production. Task 4: automated array assembly

    Energy Technology Data Exchange (ETDEWEB)

    Hagerty, J.J.

    1980-06-30

    The scope of work under this contract involves specifying a process sequence which can be used in conjunction with automated equipment for the mass production of solar cell modules for terrestrial use. This process sequence is then critically analyzed from a technical and economic standpoint to determine the technological readiness of each process step for implementation. The process steps are ranked according to the degree of development effort required and according to their significance to the overall process. Under this contract the steps receiving analysis were: back contact metallization, automated cell array layup/interconnect, and module edge sealing. For automated layup/interconnect both hard automation and programmable automation (using an industrial robot) were studied. The programmable automation system was then selected for actual hardware development. Economic analysis using the SAMICS system has been performed during these studies to assure that development efforts have been directed towards the ultimate goal of price reduction. Details are given. (WHK)

  8. Development of Entrepreneurship Skill Training Module for Youths Participation in Fish Preservation and Marketing Occupation

    Directory of Open Access Journals (Sweden)

    K.K. Obiyai

    2011-03-01

    Full Text Available The study developed entrepreneurship skill training modules for empowering youths that want to venture into fish preservation and marketing occupation. The study was conducted in Bayelsa. The design used for the study is research and Development design. The sample was forty (40, consisting 30 agricultural extension agents, which were randomly selected and 10 university teachers, which were selected through purposive sampling techniques. A structured questionnaire, which adapted a four-point rating scale, was employed. The data collected was analyzed by mean and standard deviation. The result revealed that twentyseven (27 entrepreneurial skills are needed for the development of training module for fish preservation and marketing occupation. The study therefore recommended that fish farmers should be given credit facilities to enable them provide storage and processing facilities for themselves to avoid wastage, extension officers should trained periodically to enhance their performance, and training should be organized for fish farmers already in the business and intending fish farmers.

  9. Development Of A Computerized I-V-Tracing System For Solar PV Module Testing

    Directory of Open Access Journals (Sweden)

    Gour Chand Mazumder

    2015-08-01

    Full Text Available this paper is about a development work of I-V-Curve tracing system. The system is automatic and replaces manual procedure of conventional I-V-Curve tracing method for Photovoltaic Solar Cell or Panel. This system is basically a combination of several blocks consisted by electronic devices and instrument groups. Some blocks are developed for measurement requirements and some are proprietary. This instrument can be used at solar module assembling industry for panel testing. In recent years there are significant rises on the counts of these types of business in developing countries. As this particular requires much lesser cost in comparison to other such type it is expected that this device may contribute to solar industry to help manufacturing process and quality control. Universities and laboratories may also find this suitable for their purpose. Although there are some little fluctuations in the acquired data the system can analyze the module characteristics properly.

  10. Developing a service-learning module for oral health: A needs assessment

    Directory of Open Access Journals (Sweden)

    R Ebrahim

    2017-03-01

    Full Text Available Background. Service learning (SL as a pedagogy in higher education must be differentiated from other services with a primarily philanthropic intent. Dental therapy and oral hygiene students at Sefako Makgatho Health Sciences University, School of Oral Health Sciences, Pretoria, South Africa visit community sites during their 2nd year of study. However, the current curricula would need restructuring for alignment with the espoused pedagogy and standards of SL. Such an SL curriculum design would thus allow for the provision of meaningful services to communities as an integral component of these programmes. Objective. To explore (i perceptions of 2nd-year oral health students; and (ii opinions of academics with regard to the need for an SL module. Methods. Purposive sampling was used to conduct two focus group discussions with academics involved in curriculum development (n=11 and students who had previous exposure to communities (n=10. A survey containing open-ended questions was completed by 9 academics, who would implement the proposed SL module. Frequencies were calculated and data from the open questions were analysed for emergent themes. Results. Most academics (89%, n=8 indicated that working effectively with others as members of a team and developing cultural sensitivity were achievable from an SL module. Two themes emerged from the focus groups, i.e. (i enhanced teaching and learning – students could apply theoretical and clinical training in an authentic setting; and (ii standardisation of training – an SL module would ensure consistency when engaging with communities. Conclusion. The needs assessment was valuable to inform the development and implementation of the SL module.

  11. Research and development of system to utilize photovoltaic energy. Survey on the specific purpose modules; Taiyoko hatsuden riyo system no kenkyu kaihatsu. Taiyoto module ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Tatsuta, M. [New Energy and Industrial Technology Development Organization, Tokyo (Japan)

    1994-12-01

    This paper reports the survey results on the specific purpose modules for photovoltaic power generation in fiscal 1994. (1) On the feasibility survey on new application fields, it was clarified that photovoltaic power generation is applicable to extensive areas such as farmland, road, railway and public facility as latent demand sites. (2) On the optimum modules for various specific purposes, the structure, production method, cost estimation and issues of various modules were studied for desert, wasteland, coast, ocean, river, embankment, railway, road, mobile facility and arcade. (3) On the survey on new materials and material development, various conventional materials and materials promising for required performance were surveyed for every application. (4) On the survey on technology trends, the survey members participated in the first international photovoltaic energy conversion conference and the photovoltaic power generation workshop, while the members held the 1st-5th specific purpose module subcommittees. 1 tab.

  12. The development of a valid discovery-based learning module to improve students' mathematical connection

    Science.gov (United States)

    Kuneni, Erna; Mardiyana, Pramudya, Ikrar

    2017-08-01

    Geometry is the most important branch in mathematics. The purpose of teaching this material is to develop students' level of thinking for a better understanding. Otherwise, geometry in particular, has contributed students' failure in mathematics examinations. This problem occurs due to special feature in geometry which has complexity of correlation among its concept. This relates to mathematical connection. It is still difficult for students to improve this ability. This is because teachers' lack in facilitating students towards it. Eventhough, facilitating students can be in the form of teaching material. A learning module can be a solution because it consists of series activities that should be taken by students to achieve a certain goal. A series activities in this case is adopted by the phases of discovery-based learning model. Through this module, students are facilitated to discover concept by deep instruction and guidance. It can build the mathematical habits of mind and also strengthen the mathematical connection. Method used in this research was ten stages of research and development proposed by Bord and Gall. The research purpose is to create a valid learning module to improve students' mathematical connection in teaching quadrilateral. The retrieved valid module based on media expert judgment is 2,43 for eligibility chart aspect, 2,60 for eligibility presentation aspect, and 3,00 for eligibility contents aspect. Then the retrieved valid module based on material expert judgment is 3,10 for eligibility content aspect, 2,87 for eligibility presentation aspect, and 2,80 for eligibility language and legibility aspect.

  13. DEVELOPMENT OF A LOW-COST INFERENTIAL NATURAL GAS ENERGY FLOW RATE PROTOTYPE RETROFIT MODULE

    Energy Technology Data Exchange (ETDEWEB)

    E. Kelner; T.E. Owen; D.L. George; A. Minachi; M.G. Nored; C.J. Schwartz

    2004-03-01

    In 1998, Southwest Research Institute{reg_sign} began a multi-year project co-funded by the Gas Research Institute (GRI) and the U.S. Department of Energy. The project goal is to develop a working prototype instrument module for natural gas energy measurement. The module will be used to retrofit a natural gas custody transfer flow meter for energy measurement, at a cost an order of magnitude lower than a gas chromatograph. Development and evaluation of the prototype retrofit natural gas energy flow meter in 2000-2001 included: (1) evaluation of the inferential gas energy analysis algorithm using supplemental gas databases and anticipated worst-case gas mixtures; (2) identification and feasibility review of potential sensing technologies for nitrogen diluent content; (3) experimental performance evaluation of infrared absorption sensors for carbon dioxide diluent content; and (4) procurement of a custom ultrasonic transducer and redesign of the ultrasonic pulse reflection correlation sensor for precision speed-of-sound measurements. A prototype energy meter module containing improved carbon dioxide and speed-of-sound sensors was constructed and tested in the GRI Metering Research Facility at SwRI. Performance of this module using transmission-quality natural gas and gas containing supplemental carbon dioxide up to 9 mol% resulted in gas energy determinations well within the inferential algorithm worst-case tolerance of {+-}2.4 Btu/scf (nitrogen diluent gas measured by gas chromatograph). A two-week field test was performed at a gas-fired power plant to evaluate the inferential algorithm and the data acquisition requirements needed to adapt the prototype energy meter module to practical field site conditions.

  14. Development of a Hybrid Compressor/Expander Module for Automotive Fuel Cell Applications

    Energy Technology Data Exchange (ETDEWEB)

    McTaggart, Paul

    2004-12-31

    In this program TIAX LLC conducted the development of an advanced technology compressor/expander for supplying compressed air to Proton Exchange Membrane (PEM) fuel cells in transportation applications. The overall objective of this program was to develop a hybrid compressor/expander module, based on both scroll and high-speed turbomachinery technologies, which will combine the strengths of each technology to create a concept with superior performance at minimal size and cost. The resulting system was expected to have efficiency and pressure delivery capability comparable to that of a scroll-only machine, at significantly reduced system size and weight when compared to scroll-only designs. Based on the results of detailed designs and analyses of the critical system elements, the Hybrid Compressor/Expander Module concept was projected to deliver significant improvements in weight, volume and manufacturing cost relative to previous generation systems.

  15. Development of Ultrasonic Modulation Probe for Fluorescence Tomography Based on Acousto-Optic Effect

    Directory of Open Access Journals (Sweden)

    Trinh Quang Duc

    2011-01-01

    Full Text Available We have developed an ultrasonic probe for fluorescence modulation to image fluorescence within biological tissues. The probe consists of a focused ultrasonic transducer mounted on actuators for mechanical fan scanning, which can be used in contact with the measuring object aiming for clinical application. The mechanical fan scanning employed in the probe has a beneficial feature of portability. As a result, fluorescent beads, which were localized with the diameter of 2 mm at 20 mm depth in a pork meat tissue, were detected with resolution of 3 mm. The system performance denotes the feasibility of development towards the final goal of ultrasonic fluorescence modulation tomography for clinical applications.

  16. Development of gallium arsenide high-speed, low-power serial parallel interface modules: Executive summary

    Science.gov (United States)

    1988-01-01

    Final report to NASA LeRC on the development of gallium arsenide (GaAS) high-speed, low power serial/parallel interface modules. The report discusses the development and test of a family of 16, 32 and 64 bit parallel to serial and serial to parallel integrated circuits using a self aligned gate MESFET technology developed at the Honeywell Sensors and Signal Processing Laboratory. Lab testing demonstrated 1.3 GHz clock rates at a power of 300 mW. This work was accomplished under contract number NAS3-24676.

  17. Temporal development of anticipatory reflex modulation to dynamical interactions during arm movement.

    Science.gov (United States)

    Kimura, Toshitaka; Gomi, Hiroaki

    2009-10-01

    It is known that somatosensory reflex during voluntary arm movement is modulated anticipatorily according to given tasks or environments. However, when and how reflex amplitude is set remains controversial. Is the reflex modulation completed preparatorily before movement execution or does it vary with the movement? Is the reflex amplitude coded in a temporal manner or in a spatial (or state-dependent) manner? Here we studied these issues while subjects performed planar reaching movements with upcoming opposite (rightward/leftward) directions of force fields. Somatosensory reflex responses of shoulder muscles induced by a small force perturbation were evaluated at several points before the arm encountered predictable force fields after movement start. We found that the shoulder flexor reflex responses were generally higher for the rightward than for the leftward upcoming force fields, whereas the extensor reflex responses were higher for the leftward force field. This reflex amplitude depending on the upcoming force field direction became prominent as the reflex was evoked closer to the force fields, indicating continuous changes in reflex modulation during movement. An additional experiment further showed that the reflex modulation developed as a function of the temporal distance to the force fields rather than the spatial distance. Taken together, the results suggest that, in the force field interaction task, somatosensory reflex amplitude during the course of movement is set anticipatorily on the basis of an estimate of the time-to-contact rather than the state-to-contact, to upcoming dynamical interaction during voluntary movement.

  18. Research and development of MRI surface coil for TMJ MR imaging; Modulated Helmholtz surface coil

    Energy Technology Data Exchange (ETDEWEB)

    Kukimoto, Yoshiaki; Kukimoto, Kyoko (Kameda General Hospital, Kamogawa, Chiba (Japan)); Shirakawa, Toyomi

    1989-12-01

    Internal derangements of the temporomandibular joint (TMJ) are a major cause of jaw pain and dysfunction as well as other related clinical symptoms. TMJ diagnosis is the abnormal position and appearance of the disk. Most X-ray-based methods are useful for evaluating bony abnormalities, but their reduced soft-tissue contrast often makes the diagnostic evaluation of TMJ disorders difficult. Magnetic resonance (MR) imaging is a very recent addition to the medical diagnostic of TMJ diseases. MR imaging can produce high-quality tomographic images of greater soft-tissue contrast without ionizing radiation or known biological hazards. MR system was circular type Simens Magnetom 1.5 tesla. Display matrix was 256x256. A Modulated Helmholtz type coil of 17 cm in diameter was developed in Kameda General Hospital in order to increase signal to noise ratio in the area of bilateral TMJs. The distance between two coils was 16-20 cm. The head was placed in supine position in the center of two surface coils. A Modulated Helmholtz type coil: 1. Modulated Helmholtz type coil was used as an emitter and a receiver. 2. Modulated Helmholtz type coil had a pair of 17 cm coils, which were movable according to head width of each patient. 3. MR imaging of bilateral TMJs was taken at once because of no necessity to reset a surfacecoil. 4. It was easy to set positioning of the head. (author).

  19. Efficacy of a Meiosis Learning Module Developed for the Virtual Cell Animation Collection

    Science.gov (United States)

    Goff, Eric E.; Reindl, Katie M.; Johnson, Christina; McClean, Phillip; Offerdahl, Erika G.; Schroeder, Noah L.; White, Alan R.

    2017-01-01

    Recent reports calling for change in undergraduate biology education have resulted in the redesign of many introductory biology courses. Reports on one common change to course structure, the active-learning environment, have placed an emphasis on student preparation, noting that the positive outcomes of active learning in the classroom depend greatly on how well the student prepares before class. As a possible preparatory resource, we test the efficacy of a learning module developed for the Virtual Cell Animation Collection. This module presents the concepts of meiosis in an interactive, dynamic environment that has previously been shown to facilitate learning in introductory biology students. Participants (n = 534) were enrolled in an introductory biology course and were presented the concepts of meiosis in one of two treatments: the interactive-learning module or a traditional lecture session. Analysis of student achievement shows that students who viewed the learning module as their only means of conceptual presentation scored significantly higher (d = 0.40, p arsenal of tools for “flipping” undergraduate biology courses. PMID:28188282

  20. Evaluation of a personal and professional development module in an undergraduate medical curriculum in India

    Directory of Open Access Journals (Sweden)

    Ramnarayan Komattil

    2016-03-01

    Full Text Available The study aimed at evaluating the personal and professional development (PPD module in the undergraduate medical curriculum in Melaka Manipal Medical College, India. PPD hours were incorporated in the curriculum. A team of faculty members and a faculty coordinator identified relevant topics and students were introduced to topics such as medical humanities, leadership skills, communication skills, ethics, professional behavior, and patient narratives. The module was evaluated using a prevalidated course feedback questionnaire which was administered to three consecutive batches of students from March 2011 to March 2013. To analyze faculty perspectives, one to one in-depth interviews and focus group discussions were conducted by the coordinators with faculty members who conducted the PPD classes. Analysis of the course feedback form revealed that majority (80% of students agreed that the module was well prepared and was "highly relevant" to the profession. Faculty found the topics new and interdisciplinary and there was a sense of sharing responsibility and workload by the faculty. PPD modules are necessary components of the curriculum and help to mould students while they are still acquiescent as they assume their roles as doctors of the future.

  1. Evaluation of a personal and professional development module in an undergraduate medical curriculum in India.

    Science.gov (United States)

    Komattil, Ramnarayan; Hande, Shyamala Handattu; Mohammed, Ciraj Ali; Subramaniam, Barathi

    2016-03-01

    The study aimed at evaluating the personal and professional development (PPD) module in the undergraduate medical curriculum in Melaka Manipal Medical College, India. PPD hours were incorporated in the curriculum. A team of faculty members and a faculty coordinator identified relevant topics and students were introduced to topics such as medical humanities, leadership skills, communication skills, ethics, professional behavior, and patient narratives. The module was evaluated using a prevalidated course feedback questionnaire which was administered to three consecutive batches of students from March 2011 to March 2013. To analyze faculty perspectives, one to one in-depth interviews and focus group discussions were conducted by the coordinators with faculty members who conducted the PPD classes. Analysis of the course feedback form revealed that majority (80%) of students agreed that the module was well prepared and was "highly relevant" to the profession. Faculty found the topics new and interdisciplinary and there was a sense of sharing responsibility and workload by the faculty. PPD modules are necessary components of the curriculum and help to mould students while they are still acquiescent as they assume their roles as doctors of the future.

  2. Development of Web-Based Common Cause Failure (CCF) Database Module for Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun-Gyo; Hwang, Seok-Won; Shin, Tae-young [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)

    2015-05-15

    Probabilistic safety assessment (PSA) has been used to identify risk vulnerabilities and derive the safety improvement measures from construction to operation stages of nuclear power plants. In addition, risk insights from PSA can be applied to improve the designs and operation requirements of plants. However, reliability analysis methods for quantitative PSA evaluation have essentially inherent uncertainties, and it may create a distorted risk profiles because of the differences among the PSA models, plant designs, and operation status. Therefore, it is important to ensure the quality of the PSA model so that analysts identify design vulnerabilities and utilize risk information. Especially, the common cause failure (CCF) has been pointed out as one of major issues to be able to cause the uncertainty related to the PSA analysis methods and data because CCF has a large influence on the PSA results. Organization for economic cooperation and development /nuclear energy agent (OECD/NEA) has implemented an international common cause failure data exchange (ICDE) project for the CCF quality assurance through the development of the detailed analysis methodologies and data sharing. However, Korea Hydro and Nuclear Power company (KHNP) does not have the basis for the data gathering and analysis for CCF analyses. In case of methodology, the Alpha Factor parameter estimation, which can analyze uncertainties and estimate an interface factor (Impact Vector) with an ease, is ready to be applied rather than the Multi Greek Letter (MGL) method. This article summarizes the development of the plant-specific CCF database (DB) module considering the raw data collection and the analysis procedure based on the CCF parameter calculation method of ICDE. Although the portion affected by CCF in the PSA model is quite a large, the development efforts of the tools to collect and analyze data were insufficient. Currently, KHNP intends to improve PSA quality and ensure CCF data reliability by

  3. Enhancement of the Logistics Battle Command Model: Architecture Upgrades and Attrition Module Development

    Science.gov (United States)

    2017-01-05

    DISTRIBUTION STATEMENT A: Approved for public release; distribution is unlimited. TRAC-M-TM-17-010 January 2017 Enhancement of the Logistics ...17-010 January 2017 Enhancement of the Logistics Battle Command Model Architecture Upgrades and Attrition Module Development Nathan Parker... cost the Department of Defense approximately $191,000 expended by TRAC in Fiscal Years 15-17. Prepared on 20170106 TRAC Project Code # 060119 iii

  4. Development and Results of a First Generation Least Expensive Approach to Fission: Module Tests and Results

    Science.gov (United States)

    Houts, Mike; Godfroy, Tom; Pederson, Kevin; Sena, J. Tom; VanDyke, Melissa; Dickens, Ricky; Reid, Bob J.; Martin, Jim

    2000-01-01

    The use of resistance heaters to simulate heat from fission allows extensive development of fission systems to be performed in non-nuclear test facilities, saving time and money. Resistance heated tests on the Module Unfueled Thermal-hydraulic Test (MUTT) article has been performed at the Marshall Space Flight Center. This paper discusses the results of these experiments and identifies future tests to be performed.

  5. E-MODULE DEVELOPMENT FOR THE SUBJECT OF MEASURING INSTRUMENTS AND MEASUREMENT IN ELECTRONICS ENGINEERING EDUCATION

    Directory of Open Access Journals (Sweden)

    Nuryake Fajaryati

    2016-09-01

    Full Text Available This study aims to develop an e-module as a medium of learning for the practice course of Measuring Instruments and Measurement in the Department of Electronics Engineering Education of Yogyakarta State University and to determine the feasibility of the e-module. This study employed a method of research and development. The development process was conducted through four phases by using the model of Lee and Owens which consisted of analysis phase, design phase, developing and implementation phase, as well as evaluation phase.The evaluation was conducted in several stages. Firstly, an alpha test for product validation was conducted by the experts on material and media. After that, a beta test was conducted by testing the product in small group users. The subjects of this study were the students of Electronics Engineering. The instruments used to collect the data were a validation sheet and questionnaires. The results of qualitative data were then modified into quantitative data with a range of 1 to 5, then they were converted with a rating scale to determine the feasibility of the medium. The results showed that based on the alpha test, the medium was in a very high quality. Meanwhile, in the beta test of the instructional aspect, in terms of material and evaluation and the multimedia aspect the e-module was respectively considered feasible and quite feasible. The four indicators namely text, image, animation and video were all generally considered feasible. In terms of usage aspect, the e-module was considered feasible where its two indicators, namely instructions and navigation, were generally regarded as very feasible by all respondents.

  6. A Development of the Calibration Tool Applied on Analog I/O Modules for Safety-related Controller

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong-Kyun; Yun, Dong-Hwa; Lee, Myeong-Kyun; Yoo, Kwan-Woo [SOOSAN ENS Co., Seoul (Korea, Republic of)

    2016-10-15

    The purpose of this paper is to develop the calibration tool for analog input/output(I/O) modules. Those modules are components in POSAFE-Q which is a programmable logic controller(PLC) that has been developed for the evaluation of safety-related. In this paper, performance improvement of analog I/O modules is presented by developing and applying the calibration tool for each channel in analog I/O modules. With this tool, the input signal to an analog input module and the output signal from an analog output module are able to be satisfied with a reference value of sensor type and an accuracy of all modules. With RS-232 communication, the manual calibration tool is developed for analog I/O modules of an existing and up-to-date version in POSAFE-Q PLC. As a result of applying this tool, the converted value is performant for a type of input sensor and an accuracy of analog I/O modules.

  7. Twenty-Seventh Symposium (International) on Combustion. Volume 1

    Science.gov (United States)

    1998-01-01

    pollutant emissions on human driving the development of highly efficient low- health range from respiratory diseases (e.g., child- emission combustion...Systems (N. 101. Stein, S. E., Walker, J. A., Suryan, M. M., and Fahr , Peters and B. Rogg, eds.), Lecture Notes in Physics, A., in Twenty-Third Symposium...M. M., and Fahr , A., and Kawano, H., Int. j. Chem. Kinet. 21:643-666 in Twenty-Third Symposium (International) on Com- (1989). bustion, The

  8. Development and Assessment of Modules to Integrate Quantitative Skills in Introductory Biology Courses.

    Science.gov (United States)

    Hoffman, Kathleen; Leupen, Sarah; Dowell, Kathy; Kephart, Kerrie; Leips, Jeff

    2016-01-01

    Redesigning undergraduate biology courses to integrate quantitative reasoning and skill development is critical to prepare students for careers in modern medicine and scientific research. In this paper, we report on the development, implementation, and assessment of stand-alone modules that integrate quantitative reasoning into introductory biology courses. Modules are designed to improve skills in quantitative numeracy, interpreting data sets using visual tools, and making inferences about biological phenomena using mathematical/statistical models. We also examine demographic/background data that predict student improvement in these skills through exposure to these modules. We carried out pre/postassessment tests across four semesters and used student interviews in one semester to examine how students at different levels approached quantitative problems. We found that students improved in all skills in most semesters, although there was variation in the degree of improvement among skills from semester to semester. One demographic variable, transfer status, stood out as a major predictor of the degree to which students improved (transfer students achieved much lower gains every semester, despite the fact that pretest scores in each focus area were similar between transfer and nontransfer students). We propose that increased exposure to quantitative skill development in biology courses is effective at building competency in quantitative reasoning.

  9. Development of a UAS-based survey module for ecological research

    Science.gov (United States)

    Meng, R.; McMahon, A. M.; Serbin, S.

    2016-12-01

    The development of small unmanned aircraft system (UAS, learned related to FAA registration and COA procedures, requirements, and regulations in the US, accompanied by our hand-on experiences (our group currently have two COA granted and three more under review by FAA). We then introduce our design for a modular data collection software framework. This framework is open source (available on GitHub) and cross-platform compatible (written in Python), providing flexibility in development and deployment hardware configurations. In addition our framework uses a central module to coordinate the data acquisition, synchronization with the UAS control system and data storage through a common interface and interchangeable, hardware specific software modules. Utilizing this structure and a common data transfer format, the system can be easily reconfigured to meet the needs of a specific platform or operation, eliminating the need to redevelop acquisition systems for specific instrument/platform configurations. On-site data measurement tests of UAS-based survey module were conducted and data quality from multi-sensors (e.g. a high-resolution digital camera, spectroradiometer, and a thermal infrared camera) was reported. Finally, the results of this prototype study show that the UAS techniques can be used to develop a low-cost alternative for ecological research, but much effort is still needed to carefully deal with flight regulations and integrate off-the-shelf instrumentation, by the practitioner.

  10. The State of the Art Report on the Development and Manufacturing Technology of Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. S.; Jeong, Y. H.; Park, S. Y.; Lee, M. H.; Choi, B. K.; Baek, J. H.; Park, J. Y.; Kim, J. H.; Kim, H. G.; Kim, K. H

    2006-07-15

    The main objective of the present R and D on breeder blanket is the development of test blanket modules (TBMs) to be installed and tested in International Thermonuclear Experimental Reactor (ITER). In the program of the blanket development, a blanket module test in the ITER is scheduled from the beginning of the ITER operation, and the performance test of TBM in ITER is the most important milestone for the development of the DEMO blanket. The fabrication of TBMs has been required to test the basic performance of the DEMO blanket, i.e., tritium production/recovery, high-grade heat generation and radiation shielding. Therefore, the integration of the TBM systems into ITER has been investigated with the aim to check the safety, reliability and compatibility under nuclear fusion state. For this reason, in the Test Blanket Working Group (TBWG) as an activity of the International Energy Association (IEA), a variety of ITER TBMs have been proposed and investigated by each party: helium-cooled ceramic (WSG-1), helium-cooled LiPb (WSG-2), water-cooled ceramic (WSG-3), self-cooled lithium (WSG-4) and self-cooled molten salt (WSG-5) blanket systems. Because we are still deficient in investigation of TBM development, the need of development became pressing. In this report, for the development of TBM sub-module and mock-up, it is necessary to analyze and examine the state of the art on the development of manufacturing technology of TBM in other countries. And we will be applied as basic data to establish a manufacturing technology.

  11. Towards developing high-fidelity simulated learning environment training modules in audiology.

    Science.gov (United States)

    Dzulkarnain, A A; Rahmat, S; Mohd Puzi, N A F; Badzis, M

    2017-02-01

    This discussion paper reviews and synthesises the literature on simulated learning environment (SLE) from allied health sciences, medical and nursing in general and audiology specifically. The focus of the paper is on discussing the use of high-fidelity (HF) SLE and describing the challenges for developing a HF SLE for clinical audiology training. Through the review of the literature, this paper discusses seven questions, (i) What is SLE? (ii) What are the types of SLEs? (iii) How is SLE classified? (iv) What is HF SLE? (v) What types of SLEs are available in audiology and their level of fidelity? (vi) What are the components needed for developing HF SLE? (vii) What are the possible types of HF SLEs that are suitable for audiology training? Publications were identified by structured searches from three major databases PubMed, Web of Knowledge and PsychInfo and from the reference lists of relevant articles. The authors discussed and mapped the levels of fidelity of SLE audiology training modules from the literature and the learning domains involved in the clinical audiology courses. The discussion paper has highlighted that most of the existing SLE audiology training modules consist of either low- or medium-fidelity types of simulators. Those components needed to achieve a HF SLE for audiology training are also highlighted. Overall, this review recommends that the combined approach of different levels and types of SLE could be used to obtain a HF SLE training module in audiology training.

  12. Development of a lower extremity wearable exoskeleton with double compact elastic module: preliminary experiments

    Directory of Open Access Journals (Sweden)

    Y. Long

    2017-08-01

    Full Text Available In this paper, a double compact elastic module is designed and implemented in the lower extremity exoskeleton. The double compact elastic module is composed of two parts, i.e., physical human robot interaction (pHRI measurement and the elastic actuation system (EAS, which are called proximal elastic module (PEM and distal elastic module (DEM respectively. The PEM is used as the pHRI information collection device while the DEM is used as the compliance device. A novel compact parallelogram-like structure based torsional spring is designed and developed. An iterative finite element analysis (FEA based optimization process was conducted to find the optimal parameters in the search space. In the PEM, the designed torsional spring has an outer circle with a diameter of 60 mm and an inner hole with a diameter of 12 mm, while in the DEM, the torsional spring has the outer circle with a diameter of 80 mm and the inner circle with a diameter of 16 mm. The torsional spring in the PEM has a thickness of 5 mm and a weight of 60 g, while that in the DEM has a thickness of 10 mm and a weight of 80 g. The double compact elastic module prototype is embedded in the mechanical joint directly. Calibration experiments were conducted on those two elastic modules to obtain the linear torque versus angle characteristic. The calibration experimental results show that this torsional spring in the PEM has a stiffness of 60.2 Nm rad−1, which is capable of withstanding a maximum torque of 4 Nm, while that in the DEM has a stiffness of 80.2 Nm rad−1, which is capable of withstanding a maximum torque of 30 Nm. The experimental results and the simulation data show that the maximum resultant errors are 6 % for the PEM and 4 % for the DEM respectively. In this paper, an assumed regression algorithm is used to learn the human motion intent (HMI based on the pHRI collection. The HMI is defined as the angular position of the human limb joint. A

  13. Development of Advanced Low Emission Injectors and High-Bandwidth Fuel Flow Modulation Valves

    Science.gov (United States)

    Mansour, Adel

    2015-01-01

    Parker Hannifin Corporation developed the 3-Zone fuel nozzle for NASA's Environmentally Responsible Aviation Program to meet NASAs target of 75 LTO NOx reduction from CAEP6 regulation. The nozzle concept was envisioned as a drop-in replacement for currently used fuel nozzle stem, and is built up from laminates to provide energetic mixing suitable for lean direct injection mode at high combustor pressure. A high frequency fuel valve was also developed to provide fuel modulation for the pilot injector. Final testing result shows the LTO NOx level falling just shy of NASAs goal at 31.

  14. THE DEVELOPMENT OF SCIENCE LEARNING MODULE FOR CHILDRENT WITH HEARING IMPAIRMENT

    Directory of Open Access Journals (Sweden)

    Ahmad Marzuqi

    2017-02-01

    Full Text Available There are the absence of teaching materials in accordance with the characteristics and conditions of a hearing impairment children in terms of learning, especially science subjects. The characteristics of hearing impairment children is poor in their vocabularies, so that, the teaching materials emphasizing the visual aspect is necessary. This study used a Research and Development (R & D adapted by the Sugiyono model in order to produce teaching materials in the form of pictorial modules and to test their effectiveness. The result of the research showed that it was a very valid criteria with a score of 97% of the materials experts, 85% of media experts, and 93% of skilled practitioners. The score of the effectiveness of the modules was 75% with the effective criteria.

  15. Development of a frequency-modulated ultrasonic sensor inspired by bat echolocation

    Science.gov (United States)

    Kepa, Krzysztof; Abaid, Nicole

    2015-03-01

    Bats have evolved to sense using ultrasonic signals with a variety of different frequency signatures which interact with their environment. Among these signals, those with time-varying frequencies may enable the animals to gather more complex information for obstacle avoidance and target tracking. Taking inspiration from this system, we present the development of a sonar sensor capable of generating frequency-modulated ultrasonic signals. The device is based on a miniature mobile computer, with on board data capture and processing capabilities, which is designed for eventual autonomous operation in a robotic swarm. The hardware and software components of the sensor are detailed, as well their integration. Preliminary results for target detection using both frequency-modulated and constant frequency signals are discussed.

  16. Progress on the WOM (Wavelength-shifting optical module) development for IceCube

    Energy Technology Data Exchange (ETDEWEB)

    Hebecker, Dustin [DESY Zeuthen (Germany)

    2015-07-01

    For ongoing studies for the extension of the IceCube neutrino observatory to low energies (PINGU) and high energies the noise rate of the optical modules should be decreased and the effective area increased in order to improve energy resolution and overall sensitivity. The WOM (Wavelength-shifting optical module) targets this points by expanding the capture area while decreasing the size of the PMT and thus decreasing the noise rate. Photons are first captured in an organic wavelength-shifting material (WLS) that is coated on light guiding material to guide the light to two smaller PMTs. This allows to achieve a very large collection area and reduces the noise to the order of 10 Hz in comparison to 600-800 Hz (IceCube DOM). The progress on the necessary WLS paint development and substrate selection will be presented. Also a brief status / outlook on the prototype assembly will be given.

  17. Development of active edge pixel sensors and four-side buttable modules using vertical integration technologies

    CERN Document Server

    INSPIRE-00219560; Moser, H.-G.; Nisius, R.; Richter, R.H.; Terzo, S.; Weigell, P.

    2014-01-01

    We present an R&D activity focused on the development of novel modules for the upgrade of the ATLAS pixel system at the High Luminosity LHC (HL-LHC). The modules consist of n-in-p pixel sensors, 100 or 200 $\\mu$m thick, produced at VTT (Finland) with an active edge technology, which considerably reduces the dead area at the periphery of the device. The sensors are interconnected with solder bump-bonding to the ATLAS FE-I3 and FE-I4 read-out chips, and characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements will be discussed for devices before and after irradiation up to a fluence of $5\\times 10^{15}$ \

  18. A "Do-It-Yourself" Interactive Bone Structure Module: Development and Evaluation of an Online Teaching Resource

    Science.gov (United States)

    Rich, Peter; Guy, Richard

    2013-01-01

    A stand-alone online teaching module was developed to cover an area of musculoskeletal anatomy (structure of bone) found to be difficult by students. The material presented in the module was not formally presented in any other way, thus providing additional time for other curriculum components, but it was assessed in the final examination. The…

  19. Development and control of kilo-pixel MEMS deformable mirrors and spatial light modulators

    Science.gov (United States)

    Perreault, Julie Ann

    This dissertation describes the development of kilo-pixel micro-electro-mechanical optical-quality surface-micromachined deformable mirrors and spatial light modulators along with scalable control electronics. These silicon-based deformable mirrors have the potential to modulate spatial and temporal features of an optical wavefront with applications in imaging, beam-forming, and optical communication systems. Techniques to improve the manufacturing, quality, and capability of these mirrors are detailed. The new mirror system was characterized and a scalable control system was developed to coordinate and control a large array of mirrors. Three types of kilo-pixel deformable mirrors were created: continuous membrane, segmented membrane, and a hybrid stress-relieved membrane mirrors. This new class of mirrors, deformed using electrostatically actuated surface-normal actuators, have an aperature of 10 mm, a stroke of 2 mum, position repeatability of 3 nm, surface roughness of 12 nm, reflectivity of 91%, and a bandwidth in air of 7 kHz. A custom fabrication process was developed in tandem with a new mirror design to address design and layout issues including packaging, residual stress, reliability, yield, fill factor, and surface topography. A chemo-mechanical polishing process improved the surface quality of the mirrors by decreasing surface roughness from an RMS value of 46nm to 12nm. A gold coating process increased reflectivity from 42% to greater than 91% without introducing a significant amount of stress in the mirror membrane. An alternative actuator design and layout was also developed that achieved an increased stroke of 6 mum, with the potential for even longer stroke with stress reduction. The long stroke capability was realized through introduction of split electrodes, actuation membrane cuts, and a double stacked anchor architecture. A computer-driven electronic system was developed to aid in the electro-mechanical testing of these deformable mirrors. Quasi

  20. Gene expression profile of androgen modulated genes in the murine fetal developing lung

    Directory of Open Access Journals (Sweden)

    Côté Mélissa

    2010-01-01

    Full Text Available Abstract Background Accumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens in lung maturation are only partially understood. Methods To build up a better understanding of the effect of androgens on lung development, we analyzed by microarrays the expression of genes showing a sexual difference and those modulated by androgens. Lungs of murine fetuses resulting from a timely mating window of 1 hour were studied at gestational day 17 (GD17 and GD18, corresponding to the period of surge of surfactant production. Using injections of the antiandrogen flutamide to pregnant mice, we hunted for genes in fetal lungs which are transcriptionally modulated by androgens. Results Results revealed that 1844 genes were expressed with a sexual difference at GD17 and 833 at GD18. Many genes were significantly modulated by flutamide: 1597 at GD17 and 1775 at GD18. Datasets were analyzed by using in silico tools for reconstruction of cellular pathways. Between GD17 and GD18, male lungs showed an intensive transcriptional activity of proliferative pathways along with the onset of lung differentiation. Among the genes showing a sex difference or an antiandrogen modulation of their expression, we specifically identified androgen receptor interacting genes, surfactant related genes in particularly those involved in the pathway leading to phospholipid synthesis, and several genes of lung development regulator pathways. Among these latter, some genes related to Shh, FGF, TGF-beta, BMP, and Wnt signaling are modulated by sex and/or antiandrogen treatment. Conclusion Our results show clearly that there is a real delay in lung maturation between

  1. THE DEVELOPMENT AND EVALUATION OF THE QUALITIES OF THINKING SKILLS MODULE

    Directory of Open Access Journals (Sweden)

    Tee Tze Kiong

    2013-06-01

    Full Text Available Using self-instructional modules could be an alternative approach and make significant contributions to teaching and learning.  Module is a planned series of learning activities designed carefully to assist the learners to accomplish certain specific objectives based on individual differences, interest and capability on learning.  An attempt to develop and implement a modular approach on teaching thinking skills was made in the secondary school.  This paper will discuss various components of this modular approach by referring to Meyer Model.  Fleiss’s Kappa was used to determine the degree to which consensus agreement ratings vary from the rate expected by chance, with values greater than .60 indicating substantial non-chance agreement.  Fleiss’s Kappa for the inter-rater reliability score was κ = .6357, S.E. = .0990, 95% C.I. = .4416 to .8298, which can be taken to represent constant agreement among three raters for the instrument “Rating scale for the qualities of a module”.  The internal-consistency reliability value for the instrument “What you thought of the module” was α = .89 based on 38 students.  Analysis on the qualities’ evaluation revealed that eight raters showed an agreement on satisfactory level and above for all 34 items.  Meanwhile, 36 students gave positive feedbacks on the format and content of the module.

  2. Modulation of Mammary Gland Development and Milk Production by Growth Hormone Expression in GH Transgenic Goats.

    Science.gov (United States)

    Bao, Zekun; Lin, Jian; Ye, Lulu; Zhang, Qiang; Chen, Jianquan; Yang, Qian; Yu, Qinghua

    2016-01-01

    Mammary gland development during puberty and reconstruction during pregnancy and lactation is under the control of circulating endocrine hormones, such as growth hormone, which are released from the pituitary. In this study, we explored the influence of overexpression of growth hormone in the mammary gland on breast development and milk production in goats. Using transcriptome sequencing, we found that the number of highly expressed genes was greater in GH transgenic goats than non-transgenic goats. Furthermore, KEGG pathway analysis showed that the majority of the genes belonged to the MAPK signaling pathway and the ECM-receptor interaction pathway. The expression of genes related to breast development was further confirmed using qRT-PCR. Interestingly, both milk production and milk quality were increased. The results of these experiments imply that overexpression of growth hormone in the breast may stimulate breast development and enhances milk production by modulating alveolar cell proliferation or branching through the MAPK signaling pathway.

  3. Development of a new lower hybrid antenna module using a poloidal power divider

    Energy Technology Data Exchange (ETDEWEB)

    Maebara, Sunao; Seki, Masami; Suganuma, Kazuaki [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment] [and others

    1996-07-01

    The antenna using poloidal power divider is an effective method for simplification of Lower Hybrid Current Drive (LHCD) antenna system. This method should allow to reduce the power density in the antenna while maintaining a good flexibility of N{sub parallel} spectrum of waves. For this purpose, three types of poloidal power divider which split the power in three, and the 3 x 6 multi-junction module were developed. r.f. properties and outgassing of these components were evaluated using the CEA Cadarache RF Test Facility. A good power dividing ratio of 33 {+-} 4% was obtained for each of these poloidal dividers, and the reflection coefficient was lower value than 1.5%. For the 3 x 6 multi-junction, reflection coefficient was less than 1.3% and r.f. losses lower than 1.0% were measured. On the other hand, it was found in the scattering matrix analysis that reflection coefficient at plasma has to be less than a few % in order to operate these components under available conditions. In combination with two poloidal power dividers connected to the 3 x 6 multi-junction module, quasi stationary operation for r.f. injection time of 1000 sec at 300 kW was demonstrated under water cooling. In this case, it was found that the outgassing rate is in the lower range of 10{sup -7}Pam{sup 3}s{sup -1}m{sup -2} within the maximum module temperature of {approx}100degC. This report describes the experimental and analytical results of a new lower hybrid (LH) antenna module using the poloidal power divider. (author)

  4. TXESS Revolution: Utilizing TERC's EarthLabs Cryosphere Module to Support Professional Development of Texas Teachers

    Science.gov (United States)

    Odell, M.; Ellins, K. K.; Polito, E. J.; Castillo Comer, C. A.; Stocks, E.; Manganella, K.; Ledley, T. S.

    2010-12-01

    TERC’s EarthLabs project provides rigorous and engaging Earth and environmental science labs. Four existing modules illustrate sequences for learning science concepts through data analysis activities and hands-on experiments. A fifth module, developed with NSF, comprises a series of linked inquiry based activities focused on the cryosphere to help students understand concepts around change over time on multiple and embedded time scales. Teachers recruited from the NSF-OEDG-sponsored Texas Earth and Space Science (TXESS) Revolution teacher professional development program conducted a pedagogical review of the Cryosphere EarthLabs module and provided feedback on how well the materials matched high school needs in Texas and were aligned with state and national standards. Five TXESS Revolution teachers field tested the materials in their classrooms and then trained other TXESS Revolution teachers on their implementation during spring and summer 2010. Here we report on the results of PD delivery during the summer 2010 TXESS Revolution summer institute as determined by (1) a set of evaluation instruments that included a pre-post concept map activity to assess changes in workshop teachers’ understanding of the concepts presented, a pre-post test content knowledge test, and a pre-post survey of teachers’ comfort in teaching the Texas Earth and Space Science standards addressed by the module; (2) teacher reflections; and (3) focus group responses. The findings reveal that the teachers liked the module activities and felt they could use them to teach Environmental and Earth Science. They appreciated that the sequence of activities contributed to a deeper understanding and observed that the variety of methods used to present the information accommodates different learning styles. Information about the cryosphere was new to all the teachers. The content knowledge tests reveal that although teachers made appreciable gains, their understanding of cryosphere, how it changes

  5. Photovoltaic Module Thermal/Wind Performance: Long-Term Monitoring and Model Development for Energy Rating

    Energy Technology Data Exchange (ETDEWEB)

    TamizhMani, G.; Ji, L.; Tang, Y.; Petacci, L.; Osterwald, C.

    2003-06-01

    In order to predict the energy production of photovoltaic (PV) modules, it is necessary to predict the module temperature as a function of ambient temperature, wind speed, wind direction, total irradiance, and relative humidity. This paper presents a mathematical model to predict the module temperature based on the field monitored real data of module temperature, ambient temperature, wind speed, wind direction and relative humidity.

  6. A bottom-up method for module-based product platform development through mapping, clustering and matching analysis

    Institute of Scientific and Technical Information of China (English)

    ZHANG Meng; LI Guo-xi; CAO Jian-ping; GONG Jing-zhong; WU Bao-zhong

    2016-01-01

    Designing product platform could be an effective and efficient solution for manufacturing firms. Product platforms enable firms to provide increased product variety for the marketplace with as little variety between products as possible. Developed consumer products and modules within a firm can further be investigated to find out the possibility of product platform creation. A bottom-up method is proposed for module-based product platform through mapping, clustering and matching analysis. The framework and the parametric model of the method are presented, which consist of three steps: (1) mapping parameters from existing product families to functional modules, (2) clustering the modules within existing module families based on their parameters so as to generate module clusters, and selecting the satisfactory module clusters based on commonality, and (3) matching the parameters of the module clusters to the functional modules in order to capture platform elements. In addition, the parameter matching criterion and mismatching treatment are put forward to ensure the effectiveness of the platform process, while standardization and serialization of the platform element are presented. A design case of the belt conveyor is studied to demonstrate the feasibility of the proposed method.

  7. Development of an automated sample preparation module for environmental monitoring of biowarfare agents.

    Science.gov (United States)

    Hindson, Benjamin J; Brown, Steve B; Marshall, Graham D; McBride, Mary T; Makarewicz, Anthony J; Gutierrez, Dora M; Wolcott, Duane K; Metz, Thomas R; Madabhushi, Ramakrishna S; Dzenitis, John M; Colston, Billy W

    2004-07-01

    An automated sample preparation module, based upon sequential injection analysis (SIA), has been developed for use within an autonomous pathogen detection system. The SIA system interfaced aerosol sampling with multiplexed microsphere immunoassay-flow cytometric detection. Metering and sequestering of microspheres using SIA was found to be reproducible and reliable, over 24-h periods of autonomous operation. Four inbuilt immunoassay controls showed excellent immunoassay and system stability over five days of unattended continuous operation. Titration curves for two biological warfare agents, Bacillus anthracis and Yersinia pestis, obtained using the automated SIA procedure were shown to be similar to those generated using a manual microtiter plate procedure.

  8. Twenty Questions Games Always End With Yes

    CERN Document Server

    Gill, John T

    2010-01-01

    Huffman coding is often presented as the optimal solution to Twenty Questions. However, a caveat is that Twenty Questions games always end with a reply of "Yes," whereas Huffman codewords need not obey this constraint. We bring resolution to this issue, and prove that the average number of questions still lies between H(X) and H(X)+1.

  9. Capital in the Twenty-First Century

    DEFF Research Database (Denmark)

    Hansen, Per H.

    2014-01-01

    Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp......Review essay on: Capital in the Twenty-First Century. By Thomas Piketty . Translated by Arthur Goldhammer . Cambridge, Mass.: The Belknap Press of Harvard University Press, 2014. viii + 685 pp...

  10. Unilateral deafness in children affects development of multi-modal modulation and default mode networks.

    Science.gov (United States)

    Schmithorst, Vincent J; Plante, Elena; Holland, Scott

    2014-01-01

    Monaural auditory input due to congenital or acquired unilateral hearing loss (UHL) may have neurobiological effects on the developing brain. Using functional magnetic resonance imaging (fMRI), we investigated the effect of UHL on the development of functional brain networks used for cross-modal processing. Children ages 7-12 with moderate or greater unilateral hearing loss of sensorineural origin (UHL-SN; N = 21) and normal-hearing controls (N = 23) performed an fMRI-compatible adaptation of the Token Test involving listening to a sentence such as "touched the small green circle and the large blue square" and simultaneously viewing an arrow touching colored shapes on a video. Children with right or severe-to-profound UHL-SN displayed smaller activation in a region encompassing the right inferior temporal, middle temporal, and middle occipital gyrus (BA 19/37/39), evidencing differences due to monaural hearing in cross-modal modulation of the visual processing pathway. Children with UHL-SN displayed increased activation in the left posterior superior temporal gyrus, likely the result either of more effortful low-level processing of auditory stimuli or differences in cross-modal modulation of the auditory processing pathway. Additionally, children with UHL-SN displayed reduced deactivation of anterior and posterior regions of the default mode network. Results suggest that monaural hearing affects the development of brain networks related to cross-modal sensory processing and the regulation of the default network during processing of spoken language.

  11. Unilateral deafness in children affects development of multi-modal modulation and default mode networks

    Directory of Open Access Journals (Sweden)

    Vincent eSchmithorst

    2014-03-01

    Full Text Available Monaural auditory input due to congenital or acquired unilateral hearing loss (UHL may have neurobiological effects on the developing brain. Using fMRI, we investigated the effect of UHL on the development of functional brain networks used for cross-modal processing. Children ages 7-12 with moderate or greater unilateral hearing loss of sensorineural origin (UHL-SN; N = 21 and normal-hearing controls (N = 23 performed an fMRI-compatible adaptation of the Token Test involving listening to a sentence such as touched the small green circle and the large blue square and simultaneously viewing an arrow touching colored shapes on a video. Children with right or severe-to-profound UHL-SN displayed smaller activation in a region encompassing the right inferior temporal, middle temporal, and middle occipital gyrus (BA 19/37/39, evidencing differences due to monaural hearing in cross-modal modulation of the visual processing pathway. Children with UHL-SN displayed increased activation in the left posterior superior temporal gyrus, likely the result either of more effortful low-level processing of auditory stimuli or differences in cross-modal modulation of the auditory processing pathway. Additionally, children with UHL-SN displayed reduced deactivation of anterior and posterior regions of the default mode network. Results suggest that monaural hearing affects the development of brain networks related to cross-modal sensory processing and the regulation of the default network during processing of spoken language.

  12. Twenty years of physics at MAMI -What did it mean?

    Energy Technology Data Exchange (ETDEWEB)

    Mecking, B.A. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

    2006-05-15

    The development over the last twenty years of the physics program and the experimental facilities at the Mainz Microtron MAMI will be reviewed. Ground-breaking contributions have been made to the development of experimental techniques and to our understanding of the structure of nucleons and nuclei. (orig.)

  13. Twenty years of physics at MAMI --What did it mean?

    Energy Technology Data Exchange (ETDEWEB)

    Bernhard Mecking

    2006-06-01

    The development over the last twenty years of the physics program and the experimental facilities at the Mainz Microtron MAMI will be reviewed. Ground-breaking contributions have been made to the development of experimental techniques and to our understanding of the structure of nucleons and nuclei.

  14. Developing the climate schools: ecstasy module--a universal Internet-based drug prevention program.

    Science.gov (United States)

    Newton, Nicola C; Teesson, Maree; Newton, Kathyrn L

    2012-01-01

    The Climate Schools: Ecstasy module is a universal harm-minimisation school-based prevention program for adolescents aged 14 to 16 years. The program was developed to address the need for Ecstasy prevention given the increasing use of Ecstasy use among young Australians. The core content of the program is delivered over the Internet using cartoon storylines to engage students, and the teacher-driven activities reinforce the core information. The three-lesson program is embedded within the school health curriculum and is easy to implement with minimal teacher training required. The program was developed in 2010 through extensive collaboration with students (n = 8), teachers (n = 10) and health professionals (n = 10) in Sydney, Australia. This article describes the formative research and process of planning that formed the development of the program and the evidence base underpinning the approach.

  15. Development of a learning module using a virtual environment to demonstrate EMG and telerobotic control principles.

    Science.gov (United States)

    Patterson, P E

    2002-01-01

    A prototype system was developed for use as a teaching tool, allowing students to link EMG monitoring, data smoothing, robotic control, and neural network training within a rapid prototyping virtual environment (VE). The VE software allowed for the rapid development of scenarios and, when linked with EMG data input to a neural network, allowed the user to control an artificial world containing a virtual arm. Student teams then attempted to control the arm in the VE while performing the tasks by use of a neural network system they had specifically developed and trained using their own EMG signals. The results from their system were then translated into a form that enabled the control of a real robot. Students enjoyed the challenge and uniqueness of the module, and were enthusiastic about extending the concept to other areas of interest.

  16. Development of an empirical dynamic model for a Nexa PEM fuel cell power module

    Energy Technology Data Exchange (ETDEWEB)

    Soltani, Mehdi; Mohammad Taghi Bathaee, S. [Power Systems Laboratory, Department of Electrical Engineering, K.N. Toosi University of Technology, 16317-14191 Tehran (Iran)

    2010-12-15

    The goal of this study is to develop a fuel cell model which is capable of characterizing fuel cell steady-state performance as well as dynamic behavior. In this paper a new dynamic model of a 1.2 kW Polymer Electrolyte Membrane Fuel Cell (PEMFC) is developed and validated through a series of experiments. The experimental results have been obtained from a Nexa trademark PEM fuel cell power module under different load conditions. Based on this model, a simulator software package has been developed using the MATLAB {sup registered} and Simulink {sup registered} software and simulation results have been carried out. The proposed model exhibits good agreement with experiment results in steady-state and dynamic performance. (author)

  17. Using pathway modules as targets for assay development in xenobiotic screening.

    Science.gov (United States)

    Judson, Richard S; Mortensen, Holly M; Shah, Imran; Knudsen, Thomas B; Elloumi, Fathi

    2012-02-01

    Toxicology and pharmaceutical research is increasingly making use of high throughout-screening (HTS) methods to assess the effects of chemicals on molecular pathways, cells and tissues. Whole-genome microarray analysis provides broad information on the response of biological systems to chemical exposure, but is not practical to use when thousands of chemicals need to be evaluated at multiple doses and time points, as well as across different tissues, species and life-stages. A useful alternative approach is to identify a focused set of genes that can give a coarse picture of systems-level responses and that can be scaled to the evaluation of thousands of chemicals and diverse biological contexts. We demonstrate a computational approach to select in vitro expression assay targets that are informative and broadly distributed in biological pathway space, using the concept of pathway modularity. Canonical pathways are decomposed into subnetworks (modules) of functionally-related genes based on rules such as co-regulated expression, protein-protein interactions, and coordinated physiological activity. Pathway modules are constructed using these rules but are then restricted by the bounds of canonical pathways. We demonstrate this approach using a subset of genes associated with tumor development and cancer progression. Target genes were identified for assay development, and then validated by using independent, published microarray data. The result is a targeted set of genes that are sensitive predictors of whether a chemical will perturb each pathway module. These selected genes could then form the basis for a battery to test for pathway-chemical interactions under many biological contexts using throughput expression-based assays.

  18. Which Russia, twenty years later?

    Directory of Open Access Journals (Sweden)

    Carmen Claudín

    2011-12-01

    Full Text Available Russia is proud of its position among the emerging powers, of the strength provided by its ample energetic resources and its nuclear potential with which it can influence the world and always be taken into account. Nevertheless, the perception within the country is that stagnation has become Russia’s dominant characteristic at present. The objective of this article is to explore how this situation came about, analysing the evolution of domestic processes in Russia during both of its most defining periods: Yeltsin and Putin’s leadership, since the ephemeral presidency of Medvedev proved to be basically a continuation of the latter. During the eight years of Boris Yeltsin’s tenure, the state of crisis, latent or open, developed into the way that political processes are carried out in Russia. With Putin’s arrival, however, stability and State control are imposed, against the backdrop of economic growth, and they become values in themselves, far from the democratic discourse of the first years.

  19. DNS of the turbulence modulation by dispersed particles in compressible spatially developing two-phase jets

    Institute of Scientific and Technical Information of China (English)

    LUO Kun; FAN Jianren; CEN Kefa

    2004-01-01

    A new two-way coupled direct numerical simulation (DNS) method is developed to study the turbulence modulation in the compressible and spatial developing particle-laden turbulent jets with higher Reynolds number. The high-resolution solver is performed for the gas phase flow-field and the Lagrangian method is used to trace particles. It is found that the particles with Stokes number of 0.01and 50 advance the evolution of the coherent structures in the flow-field, but the particles with Stokes number of 1 delay it. All particles increase the turbulent kinetic energy and decrease the vorticity thickness, in which the particles with the Stokes number of 1 exhibit the maximum modulation. The jet velocity half-width and the decay of the streamwise mean velocity along the centerline are reduced by particles with Stokes number of 0.01 and 1. The momentum thickness is increased by particles and the larger the Stokes number is, the larger the momentum thickness is.

  20. Development of Calculation Module for Intake Retention Functions based on Occupational Intakes of Radionuclides

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Siwan; Kwon, Tae-Eun; Lee, Jai-Ki [Hanyang Univ., Seoul (Korea, Republic of); Lee, Jong-Il; Kim, Jang-Lyul [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    In internal dosimetry, intake retention and excretion functions are essential to estimate intake activity using bioassay sample such as whole body counter, lung counter, and urine sample. Even though ICRP (International Commission on Radiological Protection)provides the functions in some ICRP publications, it is needed to calculate the functions because the functions from the publications are provided for very limited time. Thus, some computer program are generally used to calculate intake retention and excretion functions and estimate intake activity. OIR (Occupational Intakes of Radionuclides) will be published soon by ICRP, which totally replaces existing internal dosimetry models and relevant data including intake retention and excretion functions. Thus, the calculation tool for the functions is needed based on OIR. In this study, we developed calculation module for intake retention and excretion functions based on OIR using C++ programming language with Intel Math Kernel Library. In this study, we developed the intake retention and excretion function calculation module based on OIR using C++ programing language.

  1. Students' views of enquiry-based learning in a continuing professional development module.

    Science.gov (United States)

    Kirwan, Anne; Adams, John

    2009-05-01

    The purpose of this study was to explore whether qualified nurses who had undertaken a continuing professional development module at a UK university, which utilised enquiry-based learning (EBL) as the educational strategy, believed that their nursing practice had been influenced by this educational approach. This study was underpinned by the assumptions of Gadamerian hermeneutic phenomenology; semi-structured interviews were conducted with eight nurses who had undertaken a continuing education module utilising an EBL approach. The responses in this study indicate that participants believed that their practice of nursing had been positively influenced by engaging in EBL. They felt that by becoming self-directed, critical, reflective practitioners, they were better able to deliver evidence-based practice/care. Self reports of practice change attributed to engaging in EBL were provided, with the patient identified as the principal beneficiary, echoing the espoused aims of continuing professional development. EBL was credited with being a motivating, energizing and enjoyable way of learning but participants were critical of the lack of preparedness of both the students and facilitators. Consideration needs to given as to whether EBL is viewed as a philosophy of learning or as a facilitative strategy used alongside other educational methods.

  2. RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans.

    Science.gov (United States)

    Xiao, Rui; Chun, Lei; Ronan, Elizabeth A; Friedman, David I; Liu, Jianfeng; Xu, X Z Shawn

    2015-05-19

    Diet affects nearly every aspect of animal life such as development, metabolism, behavior, and aging, both directly by supplying nutrients and indirectly through gut microbiota. C. elegans feeds on bacteria, and like other animals, different bacterial diets induce distinct dietary responses in the worm. However, the lack of certain critical tools hampers the use of worms as a model for dietary signaling. Here, we genetically engineered the bacterial strain OP50, the standard laboratory diet for C. elegans, making it compatible for dsRNA production and delivery. Using this RNAi-compatible OP50 strain and the other bacterial strain HT115, we feed worms different diets while delivering RNAi to interrogate the genetic basis underlying diet-dependent differential modulation of development, metabolism, behavior, and aging. We show by RNAi that neuroendocrine and mTOR pathways are involved in mediating differential dietary responses. This genetic tool greatly facilitates the use of C. elegans as a model for dietary signaling.

  3. Development of Reduced Activation Ferritic-Martensitic Steels and fabrication technologies for Indian test blanket module

    Energy Technology Data Exchange (ETDEWEB)

    Raj, Baldev [Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102 (India); Jayakumar, T., E-mail: tjk@igcar.gov.in [Indira Gandhi Centre for Atomic Research, Kalpakkam 603 102 (India)

    2011-10-01

    For the development of Reduced Activation Ferritic-Martensitic Steel (RAFMS), for the Indian Test Blanket Module for ITER, a 3-phase programme has been adopted. The first phase consists of melting and detailed characterization of a laboratory scale heat conforming to Eurofer 97 composition, to demonstrate the capability of the Indian industry for producing fusion grade steel. In the second phase which is currently in progress, the chemical composition will be optimized with respect to tungsten and tantalum for better combination of mechanical properties. Characterization of the optimized commercial scale India-specific RAFM steel will be carried out in the third phase. The first phase of the programme has been successfully completed and the tensile, impact and creep properties are comparable with Eurofer 97. Laser and electron beam welding parameters have been optimized and welding consumables were developed for Narrow Gap - Gas Tungsten Arc welding and for laser-hybrid welding.

  4. Twenty-year Sino-Russian Relations:Strategic Cooperation of Stable Development%中俄关系二十年:稳步发展的战略协作

    Institute of Scientific and Technical Information of China (English)

    黄庆; 张萍

    2013-01-01

      1992年,中俄两国友好国家关系正式确立。20多年来,中俄关系经历了跨越式发展的叶利钦时期,也经历了全面、务实推进的普京、梅德韦杰夫时期,中俄战略协作关系稳步发展,在政治、经贸、军事、文化等各个方面都取得了引人瞩目的成就。在当前复杂多变的国际大背景下,中俄关系具有坚实的战略协作基础,但也面临着缺乏深层互信、经贸合作长期滞后等重要问题。2012年,普京第三次入主克里姆林宫,中共十八大选举出新一届中央领导集体。2012—2013年度,中俄新一届领导人实现了互访,为中俄战略协作把脉。未来十年,中俄关系的发展存在巨大潜力与机遇。%In 1992, China and Russia officially established relations of friendly countries. For more than twenty years, the Sino-Russian relations have undergone the time of Yeltsin in which the relations had a leap-over development and the time of Putin and Medvedev in which the relations were pushed on in an all-round and pragmatic way. The Sino-Russian relations of strategic cooperation have won a stable development and made noticeable achievements in politics, economy, military affairs and culture, etc. The Sino-Russian relations have a firm basis of strategic cooperation against a complex and changeable international background, but also meet some problems such as a shortage of deep-level mutual trust and a long-term stagnation of economic and trade cooperation. In 2012, Putin became the master of Kremlin for the third time and the Chinese leaders collective of the central government were elected at the Eighteenth National Congress. In the year of 2012-2013, the new leaders of China and Russia had mutual visits and held the helm of the Sino-Russian strategic cooperation. The development of the Sino-Russian relations has a great potential and opportunity in the ten years to come.

  5. ANTICIPATORY GUIDANCE MODULE CHANGES THE AUTHORITARITATIVE PARENTING OF PARENTS IN STIMULATING CHILDREN DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    M. Hasinuddin

    2017-04-01

    Full Text Available Introduction: Anticipatory guidance is a method used by nurses to help parents provide the development of behavior change towards a better understanding of their children. The purpose of this study was to analyze the provision modul of anticipatory guidance to parents and their effects on patterns of authoritarian parenting in stimulating development in kindergarten Dharmawanita Bangkalan Regency. Method: The design in this study was experimental pre post test with control group. The population was the parents of students in Dharmawanita Bangkalan kindergarten in 2010. Respondents were 15 people in the treatment group and 15 people in control group who meet the inclusion criteria. Data collected by using a questionnaire. Data then analyzed using Wilcoxon and Mann Whitney test. Result: The result showed that the differences in upbringing the parents before and after the anticipatory guidance given p value of 0.001, whereas in the control group there was no difference with a p value of 0.083. To find out the difference of counselling terms between treatment and control groups were performed by mann whitney test with p-value (0,004 < α (0.05. Discussion: Based on these results we can conclude that modul of anticipatory guidance has an impact on the upbringing of parents in stimulating growth in children in kindergarten Dharmawanita Bangkalan. Research on the effect of anticipatory guidance by the nurse to child development is necessary as a follow up of this research by considering the factors that in fl uence the development of the child itself.

  6. New developments in Seafloor observatory technologies: the SED Module developed in the MONSOON project

    Science.gov (United States)

    Italiano, Francesco; Caruso, Cinzia; Corbo, Andrea; Lazzaro, Gianluca; Nigrelli, Alessandra; Sprovieri, Mario; Oliveri, Elvira; Bagnato, Emanuela; Favali, Paolo

    2015-04-01

    In the main frame of the wide range of scientific and technological activities developed by EMSO (European Multidisciplinary Seafloor and water-column Observatory, www.emso-eu.org) Research Infrastructure. The MONSOON project (MONitoraggio SOttOmariNo for environmental and energetic purposes) is a FESR (i.e. European funds for social development) funded project by "Regione Siciliana" (industrial call). The final target of the project is to build up a prototype of a seafloor observatory named SED (Submarine Energy Device),.for which specific technological developments in terms of power consumption reduction, new data logger and new sensors have been planned. The SED observatory is planned to operate down to a water depth of 2000m in an extreme marine environment, with the presence of hydrothermal vents. SED is designed to operate as "stand-alone" or near-real-time observatory when connected to a buoy. The final version of the prototype it is planned to be released in June-July 2015 after tests completion. All the components of the observatory have been planned and laboratory-tested by the INGV and CNR public Research Institutions, while the executive plan and the manufacturing has been carried out by the industrial partnership (Eurobuilding SpA, Hitec2000 srl and Innova SpA). All the partners are going to take care of the tests in a real environment. The selected test site is located in the Aeolian islands where the shallow hydrothermal system off the coasts of the Panarea island provided an easy-to access extreme submarine environment with temperatures up to 140°C, pH less than 3 and electrical conductivity double of the normal sea-water. In this hostile environment we tested all the materials planned to be used to manufacture the different parts of the observatory, as well as all the sensors including those off-the-shelf and those planned within the MONSOON project: probes for acoustic signals, dissolved CO2 data, optical fibre-based temperature and pressure The

  7. cAMP Modulates Macrophage Development by Suppressing M-CSF-Induced MAPKs Activation

    Institute of Scientific and Technical Information of China (English)

    Ning Zhu; Jian Cui; Chunxia Qiao; Yan Li; Yuanfang Ma; Jiyan Zhang; Beifen Shen

    2008-01-01

    M-CSF is a key cytokine in macrophage development by inducing MAPKs activation, and cAMP can inhibit MAPKs activation induced by inflammatory stimuli. To explore the effects of cAMP on M-CSF-induced MAPKs activation and on macrophage development, the model of bone marrow-derived murine macrophages (BMMs) was used. The effects of cAMP on M-CSF-induced MAPKs activation were analyzed by Western blotting assay, and the effects of cAMP on CD14 and F4/80 expression during macrophage development were examined by FACS analysis.Macrophage morphology showed the successful establishment of the model of macrophage development. Western blotting assay revealed that M-CSF activated ERK, JNK and p38 in both mature and immature macrophages, and cAMP inhibited M-CSF-induced ERK, JNK and p38 activation in a time-dependent manner. FACS analysis revealed that macrophage development was impaired with cAMP pretreatment. In conclusion, cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation.

  8. The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

    Science.gov (United States)

    Arentsen, T; Qian, Y; Gkotzis, S; Femenia, T; Wang, T; Udekwu, K; Forssberg, H; Diaz Heijtz, R

    2017-01-01

    Recent studies have revealed that the gut microbiota modulates brain development and behavior, but the underlying mechanisms are still poorly understood. Here, we show that bacterial peptidoglycan (PGN) derived from the commensal gut microbiota can be translocated into the brain and sensed by specific pattern-recognition receptors (PRRs) of the innate immune system. Using expression-profiling techniques, we demonstrate that two families of PRRs that specifically detect PGN (that is, PGN-recognition proteins and NOD-like receptors), and the PGN transporter PepT1 are highly expressed in the developing brain during specific windows of postnatal development in both males and females. Moreover, we show that the expression of several PGN-sensing molecules and PepT1 in the developing striatum is sensitive to manipulations of the gut microbiota (that is, germ-free conditions and antibiotic treatment). Finally, we used the PGN-recognition protein 2 (Pglyrp2) knockout mice to examine the potential influence of PGN-sensing molecules on brain development and behavior. We demonstrate that the absence of Pglyrp2 leads to alterations in the expression of the autism risk gene c-Met, and sex-dependent changes in social behavior, similar to mice with manipulated microbiota. These findings suggest that the central activation of PRRs by microbial products could be one of the signaling pathways mediating the communication between the gut microbiota and the developing brain. PMID:27843150

  9. Development of high-resolution detector module with depth of interaction identification for positron emission tomography

    Science.gov (United States)

    Niknejad, Tahereh; Pizzichemi, Marco; Stringhini, Gianluca; Auffray, Etiennette; Bugalho, Ricardo; Da Silva, Jose Carlos; Di Francesco, Agostino; Ferramacho, Luis; Lecoq, Paul; Leong, Carlos; Paganoni, Marco; Rolo, Manuel; Silva, Rui; Silveira, Miguel; Tavernier, Stefaan; Varela, Joao; Zorraquino, Carlos

    2017-02-01

    We have developed a Time-of-flight high resolution and commercially viable detector module for the application in small PET scanners. A new approach to depth of interaction (DOI) encoding with low complexity for a pixelated crystal array using a single side readout and 4-to-1 coupling between scintillators and photodetectors was investigated. In this method the DOI information is estimated using the light sharing technique. The detector module is a 1.53×1.53×15 mm3 matrix of 8×8 LYSO scintillator with lateral surfaces optically depolished separated by reflective foils. The crystal array is optically coupled to 4×4 silicon photomultipliers (SiPM) array and readout by a high performance front-end ASIC with TDC capability (50 ps time binning). The results show an excellent crystal identification for all the scintillators in the matrix, a timing resolution of 530 ps, an average DOI resolution of 5.17 mm FWHM and an average energy resolution of 18.29% FWHM.

  10. Design and development of micro-strip stacked module prototypes to measure flying particle directions

    Energy Technology Data Exchange (ETDEWEB)

    Bernardini, J [Scuola Normale Superiore di Pisa, Piazza dei Cavalieri, 7, 56126 Pisa (Italy); Bosi, F; Dell' Orso, R; Palla, F; Profeti, A; Verdini, P G [Istituto Nazionale di Fisica Nucleare sezione di Pisa, Edificio C - Polo Fibonacci Largo B. Pontecorvo, 3 - 56127 Pisa (Italy); Fiori, F; Messineo, A, E-mail: alberto.messineo@infn.i [Universita degli Studi di Pisa, Lungarno Pacinotti, 43 - 56126 Pisa (Italy)

    2010-07-15

    Experience at high luminosity hadron collider experiments shows that tracking information enhances the trigger rejection capabilities while retaining high efficiency for interesting physics events. The design of a tracking based trigger for Super LHC (S-LHC), the already envisaged high luminosity upgrade of the LHC collider, is an extremely challenging task, and requires the identification of high-momentum particle tracks as a part of the Level 1 Trigger. Simulation studies show that this can be achieved by correlating hits on two closely spaced silicon strip sensors. This work focuses on the design and development of micro-strip stacked prototype modules and will also discuss the technical challenges in the construction and final detector performance. Studies of possible sensor spacing and wire-bonding techniques will be also presented. The prototypes have been built with the silicon sensors and electronics used to equip the present CMS Tracker. Correlation of signals collected from sensors are processed off detector. We will present the results of tests performed on the prototype modules in terms of the noise performance of the proposed stack geometry. Preliminary results in terms of signal over noise and tracking performance with cosmic rays will also be shown.

  11. Development of an Air-Source Heat Pump Integrated with a Water Heating / Dehumidification Module

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C Keith [ORNL; Uselton, Robert B. [Lennox Industries, Inc; Shen, Bo [ORNL; Baxter, Van D [ORNL; Shrestha, Som S [ORNL

    2014-01-01

    A residential-sized dual air-source integrated heat pump (AS-IHP) concept is under development in partnership between ORNL and a manufacturer. The concept design consists of a two-stage air-source heat pump (ASHP) coupled on the air distribution side with a separate novel water heating/dehumidification (WH/DH) module. The motivation for this unusual equipment combination is the forecast trend for home sensible loads to be reduced more than latent loads. Integration of water heating with a space dehumidification cycle addresses humidity control while performing double-duty. This approach can be applied to retrofit/upgrade applications as well as new construction. A WH/DH module capable of ~1.47 L/h water removal and ~2 kW water heating capacity was assembled by the manufacturer. A heat pump system model was used to guide the controls design; lab testing was conducted and used to calibrate the models. Performance maps were generated and used in a TRNSYS sub-hourly simulation to predict annual performance in a well-insulated house. Annual HVAC/WH energy savings of ~35% are predicted in cold and hot-humid U.S. climates compared to a minimum efficiency baseline.

  12. Design and development of micro-strip stacked module prototypes to measure flying particle directions

    Energy Technology Data Exchange (ETDEWEB)

    Bernardini, J. [Scuola Normale Superiore di Pisa, Piazza dei Cavalieri, 7 - 56126 Pisa (Italy); Bosi, F. [Istituto Nazionale di Fisica Nucleare - Sezione di Pisa, Edificio C - Polo Fibonacci Largo B. Pontecorvo, 3 - 56127 Pisa (Italy); Dell' Orso, R., E-mail: roberto.dellorso@pi.infn.it [Istituto Nazionale di Fisica Nucleare - Sezione di Pisa, Edificio C - Polo Fibonacci Largo B. Pontecorvo, 3 - 56127 Pisa (Italy); Fiori, F.; Messineo, A. [Universita degli Studi di Pisa, Lungarno Pacinotti, 43 - 56126 Pisa (Italy); Palla, F.; Profeti, A.; Verdini, P.G. [Istituto Nazionale di Fisica Nucleare - Sezione di Pisa, Edificio C - Polo Fibonacci Largo B. Pontecorvo, 3 - 56127 Pisa (Italy)

    2011-06-15

    Experience at high luminosity hadron collider experiments shows that tracking information enhances the trigger rejection capabilities while retaining high efficiency for interesting physics events [F. Palla and G. Parrini, Tracking in the trigger: from the CDF experience to CMS upgrade, 2007. Published in PoS VER-TEX2007:034, 2007]. The design of a tracking based trigger for Super LHC (S-LHC), the already envisaged high luminosity upgrade of the LHC collider, is an extremely challenging task, and requires the identification of high-momentum particle tracks as a part of the Level 1 Trigger. Simulation studies show that this can be achieved by correlating hits on two closely spaced silicon strip sensors. This work focuses on the design and development of micro-strip stacked prototype modules and will also discuss the technical challenges in the construction and the final detector performance. Studies of possible sensor geometries and wire-bonding techniques will be also presented. The prototypes have been built with the silicon sensors and electronics used to equip the present CMS Tracker [CMS Collaboration, The CMS experiment at the CERN LHC, JINST 3:S08004:26-89, 2008]. Correlation of signals collected from sensors are processed off detector. We will present the results of tests performed on the prototype modules in terms of the noise performance of the proposed stack geometry. Preliminary results in terms of signal over noise and tracking performance with cosmic rays will also be shown.

  13. Development of computational module of regional aridity for web-GIS “Climate”

    Science.gov (United States)

    Riazanova, A. A.; Voropay, N. N.; Okladnikov, I. G.; Gordov, E. P.

    2016-11-01

    Modern global climate changes are characterized by a significant warming started in the late 1970s. According to the observation data, the average rate of warming in Russia for 1976-2012 was 0.43 °C/10 years. Additionally, the trend of annual precipitation for the same period in most parts of Russia is positive. To study the integral climate characteristics of a region, in particular, hydrothermal conditions, is of great interest. A new software module for the assessment of aridity was developed and added to an information and computing web system called “Climate”. The well-known hydrothermal coefficient of Selyaninov (HTC) was used with ECMWF ERA Interim reanalysis data for the period from 1979 to 2010. The input data (precipitation, temperature, HTC) were validated using observation data from weather stations. It was found that the ERA Interim data substantially (by 50%) underestimated the measured precipitation in the study region. The precipitation was corrected by the results. New spatially distributed precipitation and HTC data were obtained. The web system “Climate” is based on web and GIS techniques and is part of a hardware and software complex for “cloud” analysis of climatic data. It includes several climatological and meteorological datasets, as well as dedicated software modules for searching, selection, extraction, and visualization of data.

  14. Development of a High Output Fluorescent Light Module for the Commercial Plant Biotechnology Facility

    Science.gov (United States)

    Turner, Mark; Zhou, Wei-Jia; Doty, Laura (Technical Monitor)

    2000-01-01

    To maximize the use of available resources provided onboard the International Space Station, the development of an efficient lighting 1 system is critical to the overall performance of the CPBF. Not only is it important to efficiently generate photon energy, but thermal loads on the CPBF Temperature and Humidity Control System must be minimized. By utilizing optical coatings designed to produce highly diffuse reflectance in the visible wavelengths while minimizing reflectance in the infrared region, the design of the fluorescent light module for the CPBF is optimized for maximum photon flux, spatial uniformity and energy efficiency. Since the Fluorescent Light Module must be fully enclosed to meet (ISS) requirements for containment of particulates and toxic materials, heat removal from the lights presented some unique design challenges. By using the Express Rack moderate C, temperature-cooling loop, heat is rejected by means of a liquid/air coolant manifold. Heat transfer to the manifold is performed by conduction using copper fins, by forced air convection using miniature fans, and by radiation using optically selective coatings that absorb in the infrared wavelengths. Using this combination of heat transfer mechanisms builds in redundancy to prevent thermal build up and premature bulb failure.

  15. Development of active edge pixel sensors and four-side buttable modules using vertical integration technologies

    Science.gov (United States)

    Macchiolo, A.; Andricek, L.; Moser, H.-G.; Nisius, R.; Richter, R. H.; Terzo, S.; Weigell, P.

    2014-11-01

    We present an R&D activity focused on the development of novel modules for the upgrade of the ATLAS pixel system at the High Luminosity LHC (HL-LHC). The modules consist of n-in-p pixel sensors, 100 or 200 μm thick, produced at VTT (Finland) with an active edge technology, which considerably reduces the dead area at the periphery of the device. The sensors are interconnected with solder bump-bonding to the ATLAS FE-I3 and FE-I4 read-out chips, and characterised with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements will be discussed for devices before and after irradiation up to a fluence of 5 ×1015neq /cm2. We will also report on the R&D activity to obtain Inter Chip Vias (ICVs) on the ATLAS read-out chip in collaboration with the Fraunhofer Institute EMFT. This step is meant to prove the feasibility of the signal transport to the newly created readout pads on the backside of the chips allowing for four side buttable devices without the presently used cantilever for wire bonding. The read-out chips with ICVs will be interconnected to thin pixel sensors, 75 μm and 150 μm thick, with the Solid Liquid Interdiffusion (SLID) technology, which is an alternative to the standard solder bump-bonding.

  16. Development of online conferencing and web-based in-service modules for preceptor training.

    Science.gov (United States)

    Conway-Klaassen, Janice M; Brennecke, Patricia J; Wiesner, Stephen M; Spannaus-Martin, Donna J

    2012-01-01

    Over the past five years our clinical laboratory sciences (CLS) program more than doubled student enrollment to help address the workforce shortages in our state. At the same time, medical laboratory technician programs were also increasing enrollment, putting significant pressure on the already limited number of clinical training spaces. To help alleviate the impact on clinical sites, major changes were made to the traditional clinical rotation model; shifting from a clinical training to a clinical experience and a simultaneous decrease in length from 22 to 12 weeks. This change required extensive in-service training for clinical preceptors including rationale for the new clinical experience model, review of student campus education, expectations for preceptors and students, as well as developing and implementing new evaluation methods of student performance. Through funding from the Department of Labor, online interactive modules introducing the concepts of new clinical experience module for both preceptors and for students were developed. To provide a more in-depth and specific in-service for the preceptors, web-conferences were held to describe the students' didactic and laboratory educational background and to discuss the expectations and evaluations of students. Two course management system sites were developed, one for preceptors and one for students, so they could access clinical experience information and materials at any time and from any location. These course sites also allowed us to convert evaluation processes to an online format. Survey feedback from preceptors indicates that this system was well received providing a cost-effective method for preceptor education and communication.

  17. Osteoclast activity modulates B-cell development in the bone marrow.

    Science.gov (United States)

    Mansour, Anna; Anginot, Adrienne; Mancini, Stéphane J C; Schiff, Claudine; Carle, Georges F; Wakkach, Abdelilah; Blin-Wakkach, Claudine

    2011-07-01

    B-cell development is dependent on the interactions between B-cell precursors and bone marrow stromal cells, but the role of osteoclasts (OCLs) in this process remains unknown. B lymphocytopenia is a characteristic of osteopetrosis, suggesting a modulation of B lymphopoiesis by OCL activity. To address this question, we first rescued OCL function in osteopetrotic oc/oc mice by dendritic cell transfer, leading to a restoration of both bone phenotype and B-cell development. To further explore the link between OCL activity and B lymphopoiesis, we induced osteopetrosis in normal mice by injections of zoledronic acid (ZA), an inhibitor of bone resorption. B-cell number decreased specifically in the bone marrow of ZA-treated mice. ZA did not directly affect B-cell differentiation, proliferation and apoptosis, but induced a decrease in the expression of CXCL12 and IL-7 by stromal cells, associated with reduced osteoblastic engagement. Equivalent low osteoblastic engagement in oc/oc mice confirmed that it resulted from the reduced OCL activity rather than from a direct effect of ZA on osteoblasts. These dramatic alterations of the bone microenvironment were disadvantageous for B lymphopoiesis, leading to retention of B-cell progenitors outside of their bone marrow niches in the ZA-induced osteopetrotic model. Altogether, our data revealed that OCLs modulate B-cell development in the bone marrow by controlling the bone microenvironment and the fate of osteoblasts. They provide novel basis for the regulation of the retention of B cells in their niche by OCL activity.

  18. Osteoclast activity modulates B-cell development in the bone marrow

    Institute of Scientific and Technical Information of China (English)

    Anna Mansour; Adrienne Anginot; Stéphane J C Mancini; Claudine Schiff; Georges F Carle; Abdelilah Wakkach; Claudine Blin-Wakkach

    2011-01-01

    B-cell development is dependent on the interactions between B-cell precursors and bone marrow stromal cells, but the role of osteoclasts (OCLs) in this process remains unknown. B lymphocytopenia is a characteristic of osteopetrosis, suggesting a modulation of B lymphopoiesis by OCL activity. To address this question, we first rescued OCL function in osteopetrotic oc/oc mice by dendritic cell transfer, leading to a restoration of both bone phenotype and B-cell development. To further explore the link between OCL activity and B lymphopoiesis, we induced osteopetrosis in normal mice by injections of zoledronic acid (ZA), an inhibitor of bone resorption. B-cell number decreased specifically in the bone marrow of ZA-treated mice. ZA did not directly affect B-cell differentiation, proliferation and apoptosis, but induced a decrease in the expression of CXCL12 and IL-7 by stromal cells, associated with reduced osteoblastic engagement. Equivalent low osteoblastic engagement in oc/oc mice confirmed that it resulted from the reduced OCL activity rather than from a direct effect of ZA on osteoblasts. These dramatic alterations of the bone microenvironment were disadvantageous for B lymphopoiesis, leading to retention of B-cell progenitors outside of their bone marrow niches in the ZA-induced osteopetrotic model. Altogether, our data revealed that OCLs modulate B-cell development in the bone marrow by controlling the bone microenvironment and the fate of osteoblasts. They provide novel basis for the regulation of the retention of B cells in their niche by OCL activity.

  19. Arabidopsis PLC2 is involved in auxin-modulated reproductive development.

    Science.gov (United States)

    Li, Lin; He, Yuqing; Wang, Yarui; Zhao, Shujuan; Chen, Xi; Ye, Tiantian; Wu, Yuxuan; Wu, Yan

    2015-11-01

    Phospholipase C (PLC) is an enzyme that plays crucial roles in various signal transduction pathways in mammalian cells. However, the role of PLC in plant development is poorly understood. Here we report involvement of PLC2 in auxin-mediated reproductive development in Arabidopsis. Disruption of PLC2 led to sterility, indicating a significant role for PLC2 in reproductive development. Development of both male and female gametophytes was severely perturbed in plc2 mutants. Moreover, elevated auxin levels were observed in plc2 floral tissues, suggesting that the infertility of plc2 plants may be associated with increased auxin concentrations in the reproductive organs. We show that expression levels of the auxin reporters DR5:GUS and DR5:GFP were elevated in plc2 anthers and ovules. In addition, we found that expression of the auxin biosynthetic YUCCA genes was increased in plc2 plants. We conclude that PLC2 is involved in auxin biosynthesis and signaling, thus modulating development of both male and female gametophytes in Arabidopsis.

  20. Powering into the twenty-first century [Singapore Power Limited

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-07-01

    To meet the challenges of the twenty-first century power industry, Singapore Power was incorporated as a commercial entity in October 1995. As the leading energy company in Singapore, SP continues to invest heavily in infrastructure development to improve its service efficiency and reliability, and to maintain its reputation as one of the world`s best power suppliers. (UK)

  1. Twenty-One: a baseline for multilingual multimedia retrieval

    NARCIS (Netherlands)

    Jong, de Franciska; Hiemstra, Djoerd; Jong, de Franciska; Netter, Klaus

    1998-01-01

    In this paper we will give a short overview of the ideas underpinning the demonstrator developed within the EU-funded project Twenty-One; this system provides for the disclosure of information in a heterogeneous document environment that includes documents of different types and languages. As part o

  2. Twenty-One: a baseline for multilingual multimedia retrieval

    NARCIS (Netherlands)

    Unknown, [Unknown; Hiemstra, Djoerd; de Jong, Franciska M.G.; Netter, Klaus

    1998-01-01

    In this paper we will give a short overview of the ideas underpinning the demonstrator developed within the EU-funded project Twenty-One; this system provides for the disclosure of information in a heterogeneous document environment that includes documents of different types and languages. As part o

  3. Development and Design of a Single-Stage Cryogenic Modulator for Comprehensive Two-Dimensional Gas Chromatography.

    Science.gov (United States)

    Mostafa, Ahmed; Górecki, Tadeusz

    2016-05-17

    A new liquid nitrogen-based single-stage cryogenic modulator was developed and characterized. In addition, a dedicated liquid nitrogen delivery system was developed. A well-defined restriction placed inside a deactivated fused silica capillary was used to increase the cooling surface area and provide very efficient trapping. At the same time, it enabled modulation of the carrier gas flow owing to changes in gas viscosity with temperature. Gas flow is almost unimpeded at the trapping temperature but reduced to nearly zero at the desorption temperature, which prevents analyte breakthrough. Peak widths for n-alkanes of 30-40 ms at half height were obtained. Most importantly, even the solvent peak could be modulated, which is not feasible with any commercially available thermal modulator. Evaluation of the newly developed system in two-dimensional gas chromatography (GC × GC) separations of some real samples such as regular gasoline and diesel fuel showed that the analytical performance of this single-stage modulator is fully competitive to those of the more complicated dual-stage modulators.

  4. Optimal machining parameters module development based on CAD/CAM system

    Science.gov (United States)

    Zhang, Jinichun; Gong, Xiansheng; Xie, Guanghui; Yin, Ling

    2011-05-01

    In view of the actual numerical control processing in cutting specifications' establishment question, take Windows as the service platform, used the grid algorithm and using VC6.0, MFC (the Microsoft foundation class) and tool research and so on C-HOOKS has developed with the MasterCAM seamless integration cutting specifications optimization module. Carries on the practical application which on the numerical control milling machine to the connecting rod mold electrode the cutting specifications optimize to indicate that through the optimization, obtained the small depth of cut and the roughing feed speed combination, the connecting rod electrode surface has pulls out the mold ascent, used the small depth of cut to enable the electrode surface to obtain the good smooth finish, its machining time saved 49%, the processing efficiency obtains the large scale promotion nearly, the product quality has the enhancement.

  5. CAPACITY BUILDING FOR CLIMATE CHANGE ADAPTATION: MODULES FOR AGRICULTURAL EXTENSION CURRICULUM DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    B.O. Ogunbameru

    2013-02-01

    Full Text Available Basically, climate change refers to any change in climate overtime, generally caused by natural variability and/or human activities. It has great devastating impact, particularly on agriculture and by extrapolation on farmers and the national economy. The frontline agricultural extension workers are expected to be among the principal stakeholders to teach farmers how to cope with climate change. Consequently, there is a need to develop appropriate teaching package for the training of the frontline agricultural extension workers, based on the myriad of adaptation strategies and practices available in the literature. This paper synthesizes the rationale for capacity building in climate change and the adaptation or coping strategies. The modules (train-the-trainer for teaching agricultural extension workers and farmers are documented in the paper.

  6. Design and development of micro-strip stacked module prototypes for tracking at S-LHC

    Energy Technology Data Exchange (ETDEWEB)

    Bernardini, J [Scuola Normale Superiore (SNS) di Pisa, P.zza Cavalieri 7, Pisa (Italy); Bosi, F; Dell' Orso, R; Fiori, F; Messineo, A; Palla, F; Profeti, A; Verdini, P G, E-mail: francesco.fiori@pi.infn.i [Istituto Nazionale di Fisica Nucleare (INFN) Pisa, L.go B. Pontecorvo 3, Pisa (Italy)

    2010-11-15

    Experience at high luminosity hadron collider experiments shows that tracking information enhances the trigger rejection capabilities while retaining high efficiency for interesting physics events [1]. The design of a tracking based trigger for Super LHC (S-LHC), the high luminosity upgrade of the LHC collider [2], is an extremely challenging task requiring the identification of high-momentum tracks as a part of the Level 1 trigger decision. Simulation studies show that this can be achieved by correlating hits on two closely spaced silicon strip sensors. This paper focuses on the design and development of micro-strip stacked prototype modules and their performance. The prototypes have been built with the silicon sensors and electronics used to equip the present CMS Tracker [3]. Correlation of signals collected from sensors are processed off detector. Preliminary results in terms of signal over noise and tracking performance with cosmic rays will be also shown.

  7. A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development.

    Science.gov (United States)

    Maurange, Cédric; Paro, Renato

    2002-10-15

    In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins interact with chromosomal elements, termed Cellular Memory Modules (CMMs). By modifying chromatin, this ensures a stable heritable maintenance of the transcriptional state of developmental regulators, like the homeotic genes, that is defined embryonically. We asked whether such CMMs could also control expression of genes involved in patterning imaginal discs during larval development. Our results demonstrate that expression of the hedgehog gene, once activated, is maintained by a CMM. In addition, our experiments indicate that the switching of such CMMs to an active state during larval stages, in contrast to embryonic stages, may require specific trans-activators. Our results suggest that the patterning of cells in particular developmental fields in the imaginal discs does not only rely on external cues from morphogens, but also depends on the previous history of the cells, as the control by CMMs ensures a preformatted gene expression pattern.

  8. Development of the Orion Crew-Service Module Umbilical Retention and Release Mechanism

    Science.gov (United States)

    Delap, Damon C.; Glidden, Joel Micah; Lamoreaux, Christopher

    2013-01-01

    The Orion CSM umbilical retention and release mechanism supports and protects all of the cross-module commodities between the spacecrafts crew and service modules. These commodities include explosive transfer lines, wiring for power and data, and flexible hoses for ground purge and life support systems. The mechanism employs a single separation interface which is retained with pyrotechnically actuated separation bolts and supports roughly two dozen electrical and fluid connectors. When module separation is commanded, either for nominal on-orbit CONOPS or in the event of an abort, the mechanism must release the separation interface and sever all commodity connections within milliseconds of command receipt. There are a number of unique and novel aspects of the design solution developed by the Orion mechanisms team. The design is highly modular and can easily be adapted to other vehiclesmodules and alternate commodity sets. It will be flight tested during Orions Exploration Flight Test 1 (EFT-1) in 2014, and the Orion team anticipates reuse of the design for all future missions. The design packages fluid, electrical, and ordnance disconnects in a single separation interface. It supports abort separations even in cases where aerodynamic loading prevents the deployment of the umbilical arm. Unlike the Apollo CSM umbilical which was a destructive separation device, the Orion design is resettable and flight units can be tested for separation performance prior to flight.Initial development testing of the mechanisms separation interface resulted in binding failures due to connector misalignments. The separation interface was redesigned with a robust linear guide system, and the connector separation and boom deployment were separated into two discretely sequenced events. These changes addressed the root cause of the binding failure by providing better control of connector alignment. The new design was tuned and validated analytically via Monte Carlo simulation. The

  9. Development and experimental study of oil-free capacitor module for plasma focus device

    Science.gov (United States)

    Sharma, Ravindra Kumar; Sharma, Archana

    2017-03-01

    This development is concerned with the compact capacitor module for a plasma focus device. Oil-free, non-standard geometry capacitors are designed and developed for high current delivery in sub-microseconds time. Metalized dielectric film based pulse capacitor becomes progressively less viable at currents above 10 kA. It is due to reliability and energy scaling difficulties, based on effects such as vaporization, high resistivity, and end connection. Bipolar electrolytic capacitors are also not preferred due to their limited life and comparatively low peak current delivery. Bi-axially oriented polypropylene (BOPP) film with extended aluminum foil is a combination to deliver moderately high power. But, electrically weak points, relative permittivity, and the edge gap margins have made its adoption difficult. A concept has been developed in lab for implementing the above combination in a less complex and costly manner. This paper concerns the development and testing process techniques for quite different hollow cylindrical, oil-free capacitors (4 μ F , 10 kV, 20 nH). Shot life of 1000 has been experimentally performed on the test bed at its rated energy density level. The technological methods and engineering techniques are now available and utilized for manufacturing and testing of BOPP film based oil-free capacitors.

  10. Condition monitoring requirements for the development of a space nuclear propulsion module

    Science.gov (United States)

    Wagner, Robert C.

    1993-01-01

    To facilitate the development of a space nuclear propulsion module for manned flights to Mars, requirements must be established early in the technology cycle. The long lead times for the acquisition of the engine system and nuclear test facilities demands that the engine system, size, performance, safety goals and condition monitoring philosophy be defined at the earliest possible time. These systems are highly complex and require a large multi-disciplinary systems engineering team to develop and track the requirements and to ensure that the as-built system reflects the intent of the mission. An effective methodology has been devised coupled with sophisticated computer tools to effectivly develop and interpret the functional requirements. These requirements can then be decomposed down to the specification level for implementation. This paper discusses the application of the methodology and the analyses to develop condition monitoring requirements under a contract with the National Aeronautics and Space Administration (NASA) Lewis Research Center (LeRC) Nuclear Propulsion Office (NPO).

  11. Development of a Study Module on and Pedagogical Approaches to Industrial Environmental Engineering and Sustainability in Mozambique

    Science.gov (United States)

    Husgafvel, Roope; Martikka, Mikko; Egas, Andrade; Ribiero, Natasha; Dahl, Olli

    2017-01-01

    Addressing the sustainability challenges in the forest sector in Mozambique requires capacity building for higher education and training of new skilled expert and future decision-makers. Our approach was to develop a study module on and pedagogical approaches to industrial environmental engineering and sustainability. The idea was to develop a…

  12. TCP15 modulates cytokinin and auxin responses during gynoecium development in Arabidopsis.

    Science.gov (United States)

    Lucero, Leandro E; Uberti-Manassero, Nora G; Arce, Agustín L; Colombatti, Francisco; Alemano, Sergio G; Gonzalez, Daniel H

    2015-10-01

    We studied the role of Arabidopsis thaliana TCP15, a member of the TEOSINTE BRANCHED1-CYCLOIDEA-PCF (TCP) transcription factor family, in gynoecium development. Plants that express TCP15 from the 35S CaMV promoter (35S:TCP15) develop flowers with defects in carpel fusion and a reduced number of stigmatic papillae. In contrast, the expression of TCP15 fused to a repressor domain from its own promoter causes the development of outgrowths topped with stigmatic papillae from the replum. 35S:TCP15 plants show lower levels of the auxin indoleacetic acid and reduced expression of the auxin reporter DR5 and the auxin biosynthesis genes YUCCA1 and YUCCA4, suggesting that TCP15 is a repressor of auxin biosynthesis. Treatment of plants with cytokinin enhances the developmental effects of expressing TCP15 or its repressor form. In addition, treatment of a knock-out double mutant in TCP15 and the related gene TCP14 with cytokinin causes replum enlargement, increased development of outgrowths, and the induction of the auxin biosynthesis genes YUCCA1 and YUCCA4. A comparison of the phenotypes observed after cytokinin treatment of plants with altered expression levels of TCP15 and auxin biosynthesis genes suggests that TCP15 modulates gynoecium development by influencing auxin homeostasis. We propose that the correct development of the different tissues of the gynoecium requires a balance between auxin levels and cytokinin responses, and that TCP15 participates in a feedback loop that helps to adjust this balance.

  13. Development of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module

    Directory of Open Access Journals (Sweden)

    Terasaki Mizuhiko

    2010-04-01

    Full Text Available Abstract Background The Pediatric Quality of Life Inventory™ (PedsQL™ is a widely-used modular instrument for measuring health-related quality of life in children aged 2 to 18 years. The PedsQL™ Brain Tumor Module is comprised of six scales: Cognitive Problems, Pain and Hurt, Movement and Balance, Procedural Anxiety, Nausea, and Worry. In the present study, we developed the Japanese version of the PedsQL™ Brain Tumor Module and investigated its feasibility, reliability, and validity among Japanese children and their parents. Methods Translation equivalence and content validity were verified using the standard back-translation method and cognitive debriefing tests. Participants were recruited from 6 hospitals in Japan and the Children's Cancer Association of Japan, and questionnaires were completed by 137 children with brain tumors and 166 parents. Feasibility of the questionnaire was determined based on the amount of time required to complete the form and the percentage of missing values. Internal consistency was assessed using Cronbach's coefficient alpha. Test-retest reliability was assessed by retesting 22 children and 27 parents. Factorial validity was verified by exploratory factor analyses. Known-groups validity was described with regard to whole brain irradiation, developmental impairment, infratentorial tumors, paresis, and concurrent chemotherapy. Convergent and discriminant validity were determined using Generic Core Scales and State-Trait Anxiety Inventory for children. Results Internal consistency was relatively high for all scales (Cronbach's coefficient alpha > 0.70 except the Pain and Hurt scale for the child-report, and sufficient test-retest reliability was demonstrated for all scales (intraclass correlation coefficient = 0.45-0.95. Factorial validity was supported through exploratory factor analysis (factor-item correlation = 0.33-0.96 for children, 0.55-1.00 for parents. Evaluation of known-groups validity confirmed

  14. Development of a Respiratory Inductive Plethysmography Module Supporting Multiple Sensors for Wearable Systems

    OpenAIRE

    2012-01-01

    In this paper, we present an RIP module with the features of supporting multiple inductive sensors, no variable frequency LC oscillator, low power consumption, and automatic gain adjustment for each channel. Based on the method of inductance measurement without using a variable frequency LC oscillator, we further integrate pulse amplitude modulation and time division multiplexing scheme into a module to support multiple RIP sensors. All inductive sensors are excited by a high-frequency electr...

  15. [Influence of root module design on growth and development of plants].

    Science.gov (United States)

    Krivobok, N M; Berkovich, Iu A; Krivobok, S M; Smolianina, S O

    2000-01-01

    Wheat crop was grown in various root modules (RM) in which nutritional solution was injected through porous membrane (2-6 microns). Seeds were laid on the surface of membrane or in pearlite covering the membrane. Root modules 1 and 3 contained ceramic porous tubes 10 mm and 22 mm in diameter, respectively. RM 2 was outfitted with a porous titanium plate, RM 4--with a porous ceramic tube (Ø 10 mm) buried in pearlite, and RM 5--with a porous titanium plate under the 2.5 cm thick layer of pearlite. The area of membrane surface per one plant was equal to 3 cm2 in RM 1 and about 17 cm2 RM 2 and 3. Pearlite volume per a plant made up about 40 cm2 in RM 4.5. The object of study was Triticum aestivum L., sp. Super Dwarf. The plants grew for 49 days under the white light of luminescent lamps at water potential (WP) = -0.4, -3.0 and -5.0 kPa. WP of pearlite equal, dry mass and anticipated productivity of the crop were much higher as compared to RM without pearlite. Significant reduction of these parameters was reflective of WP drop no matter the RM type. However, it was more expressed at -5 kPa. In RM filled with pearlite the mass and productivity of crop reduced at -5.0 kPa. Design of RM essentially altered the volumetric spread of roots. Thus, root math was formed immediately on flat porous plates, commonly below the bare tubes and both on top and on the bottom of RM with pearlite. These data can help development of RM for space greenhouses.

  16. Discovery & development of small molecule allosteric modulators of glycoprotein hormone receptors

    Directory of Open Access Journals (Sweden)

    Selvaraj G Nataraja

    2015-09-01

    Full Text Available Glycoprotein hormones, follicle-stimulating hormone (FSH, luteinizing hormone (LH, and thyroid stimulating hormone (TSH are heterodimeric proteins with a common subunit and hormone-specific subunit. These hormones are dominant regulators of reproduction and metabolic processes. Receptors for the glycoprotein hormones belong to the family of G-protein coupled receptors (GPCR. FSH receptor (FSHR and LH receptor (LHR are primarily expressed in somatic cells in ovary and testis to promote egg and sperm production in women & men respectively. TSH receptor (TSHR is expressed in thyroid cells and regulates the secretion of T3 & T4. Glycoprotein hormones bind to the large extracellular domain of the receptor and cause a conformational change in the receptor that leads to activation of more than one intracellular signaling pathway. Several small molecules have been described to activate/inhibit glycoprotein hormone receptors through allosteric sites of the receptor. Small molecule allosteric modulators have the potential to be administered orally to patients thus improving the convenience of treatment. It has been a challenge to develop a small molecule allosteric agonist for glycoprotein hormones that can mimic the agonistic effects of the large natural ligand to activate similar signaling pathways. However, in the past few years, there have been several promising reports describing distinct chemical series with improved potency in preclinical models. In parallel, proposal of new structural model for FSH receptor and in silico docking studies of small molecule ligands to glycoprotein hormone receptors provide a giant leap on the understanding of the mechanism of action of the natural ligands and new chemical entities on the receptors. This review will focus on the current status of small molecule allosteric modulators of glycoprotein hormone receptors, their effects on common signaling pathways in cells, their utility for clinical

  17. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Science.gov (United States)

    Miendlarzewska, Ewa A; Trost, Wiebke J

    2013-01-01

    Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development.

  18. How musical training affects cognitive development: rhythm, reward and other modulating variables.

    Directory of Open Access Journals (Sweden)

    Ewa Aurelia Miendlarzewska

    2014-01-01

    Full Text Available Musical training has recently gained additional interest in education as increasing neuroscientific research demonstrates its positive effects on brain development. Neuroimaging revealed plastic changes in the brains of adult musicians but it is still unclear to what extent they are the product of intensive music training rather than of other factors, such as preexisting biological markers of musicality. In this review, we synthesize a large body of studies demonstrating that benefits of musical training extend beyond the skills it directly aims to train and last well into adulthood. For example, children who undergo musical training have better verbal memory, second language pronunciation accuracy, reading ability and executive functions. Learning to play an instrument as a child may even predict academic performance and IQ in young adulthood. The degree of observed structural and functional adaptation in the brain correlates with intensity and duration of practice. Importantly, the effects on cognitive development depend on the timing of musical initiation due to sensitive periods during development, as well as on several other modulating variables. Notably, we point to motivation, reward and social context of musical education, which are important yet neglected factors affecting the long-term benefits of musical training. Further, we introduce the notion of rhythmic entrainment and suggest that it may represent a mechanism supporting learning and development of executive functions. It also hones temporal processing and orienting of attention in time that may underlie enhancements observed in reading and verbal memory. We conclude that musical training uniquely engenders near and far transfer effects, preparing a foundation for a range of skills, and thus fostering cognitive development.

  19. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

    Science.gov (United States)

    Roques, Magali; Wall, Richard J; Douglass, Alexander P; Ramaprasad, Abhinay; Ferguson, David J P; Kaindama, Mbinda L; Brusini, Lorenzo; Joshi, Nimitray; Rchiad, Zineb; Brady, Declan; Guttery, David S; Wheatley, Sally P; Yamano, Hiroyuki; Holder, Anthony A; Pain, Arnab; Wickstead, Bill; Tewari, Rita

    2015-11-01

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  20. Modulating epigenetic mechanisms: the diverse functions of Ski during cortical development.

    Science.gov (United States)

    Baranek, Constanze; Atanasoski, Suzana

    2012-07-01

    In the developing forebrain, neural stem and progenitor cells generate a large variety of neurons with specific functions in the mature cortex. A central issue is to understand the roles of transcriptional networks and regulatory pathways that control these complex developmental processes. The proto-oncogene Ski is a transcriptional regulator linked to the human 1p36 deletion syndrome, which involves a set of phenotypes including nervous system defects. Ski shows a dynamic expression pattern during cortical development and, accordingly, the phenotype of Ski-deficient cortices is complex, involving altered cell cycle characteristics of neural progenitors, disturbed timing of neurogenesis and mis-specification of projection neurons. Ski is likely to play a role in various pathways by virtue of its ability to interact with a range of signaling molecules, thereby modulating transcriptional activity of corresponding target genes. Ski regulates proliferation and differentiation of various cell types, and more recent data from my laboratory demonstrates that Ski is also involved in the specification of cortical projection neurons. This Point-of-View elucidates the role of Ski as an essential linker between sequence-specific transcription factors and non-DNA binding cofactors with chromatin modifying activities. In particular, it puts forward the hypothesis that the diverse functions of Ski as a co-repressor might be related to its association with distinct HDAC-complexes.

  1. Compact Dielectric Wall Accelerator Development For Intensity Modulated Proton Therapy And Homeland Security Applications

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y -; Caporaso, G J; Guethlein, G; Sampayan, S; Akana, G; Anaya, R; Blackfield, D; Cook, E; Falabella, S; Gower, E; Harris, J; Hawkins, S; Hickman, B; Holmes, C; Horner, A; Nelson, S; Paul, A; Pearson, D; Poole, B; Richardson, R; Sanders, D; Stanley, J; Sullivan, J; Wang, L; Watson, J; Weir, J

    2009-06-17

    Compact dielectric wall (DWA) accelerator technology is being developed at the Lawrence Livermore National Laboratory. The DWA accelerator uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. Its high electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The DWA concept can be applied to accelerate charge particle beams with any charge to mass ratio and energy. Based on the DWA system, a novel compact proton therapy accelerator is being developed. This proton therapy system will produce individual pulses that can be varied in intensity, energy and spot width. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. The status of the developmental new technologies that make the compact system possible will be reviewed. These include, high gradient vacuum insulators, solid dielectric materials, SiC photoconductive switches and compact proton sources. Applications of the DWA accelerator to problems in homeland security will also be discussed.

  2. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes

    KAUST Repository

    Roques, Magali

    2015-11-13

    Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P)-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  3. Olfactory experience modulates immature neuron development in postnatal and adult guinea pig piriform cortex.

    Science.gov (United States)

    He, X; Zhang, X-M; Wu, J; Fu, J; Mou, L; Lu, D-H; Cai, Y; Luo, X-G; Pan, A; Yan, X-X

    2014-02-14

    Immature neurons expressing doublecortin (DCX+) are present around cortical layer II in various mammals including guinea pigs and humans, especially enriched in the paleocortex. However, little is known whether and how functional experience affects the development of this population of neurons. We attempted to explore a modulation by experience to layer II DCX+ cells in the primary olfactory cortex in postnatal and adult guinea pigs. Neonatal and 1-year-old guinea pigs were subjected to unilateral naris-occlusion, followed 1 and 2months later by morphometry of DCX+ cells in the piriform cortex. DCX+ somata and processes were reduced in the deprived relative to the non-deprived piriform cortex in both age groups at the two surviving time points. The number of DCX+ cells was decreased in the deprived side relative to internal control at 1 and 2months in the youths and at 2months in the adults post-occlusion. The mean somal area of DCX+ cells showed a trend of decrease in the deprived side relative to the internal control in the youths. In addition, DCX+ cells in the deprived side exhibited a lower frequency of colocalization with the neuron-specific nuclear antigen (NeuN) relative to counterparts. These results suggest that normal olfactory experience is required for the maintenance and development of DCX+ immature neurons in postnatal and adult guinea pig piriform cortex.

  4. Development and validation of a BEAMnrc component module for a miniature multileaf collimator.

    Science.gov (United States)

    Doerner, E; Hartmann, G H

    2012-05-21

    A new component module (CM) named mini multileaf collimator (mMLC) was developed for the Monte Carlo code BEAMnrc. It models the geometry of the add-on miniature multileaf collimator ModuLeaf (MRC Systems GmbH, Heidelberg, Germany, now part of Siemens, Erlangen, Germany). The new CM is partly based on the existing CM called DYNVMLC. The development was performed using a modified EGSnrc platform which enables us to work in the Microsoft Visual Studio environment. In order to validate the new CM, the PRIMUS linac with 6 MV x-rays (Siemens OCS, Concord, CA, USA) equipped with the ModuLeaf mMLC was modelled. Validation was performed by two methods: (a) a ray-tracing method to check the correct geometry of the multileaf collimator (MLC) and (b) a comparison of calculated and measured results of the following dosimetrical parameters: output factors, dose profiles, field edge position penumbra, MLC interleaf leakage and transmission values. Excellent agreement was found for all parameters. It was, in particular, found that the relationship between leaf position and field edge depending on the shape of the leaf ends can be investigated with a higher accuracy by this new CM than by measurements demonstrating the usefulness of the new CM.

  5. RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans

    Directory of Open Access Journals (Sweden)

    Rui Xiao

    2015-05-01

    Full Text Available Diet affects nearly every aspect of animal life such as development, metabolism, behavior, and aging, both directly by supplying nutrients and indirectly through gut microbiota. C. elegans feeds on bacteria, and like other animals, different bacterial diets induce distinct dietary responses in the worm. However, the lack of certain critical tools hampers the use of worms as a model for dietary signaling. Here, we genetically engineered the bacterial strain OP50, the standard laboratory diet for C. elegans, making it compatible for dsRNA production and delivery. Using this RNAi-compatible OP50 strain and the other bacterial strain HT115, we feed worms different diets while delivering RNAi to interrogate the genetic basis underlying diet-dependent differential modulation of development, metabolism, behavior, and aging. We show by RNAi that neuroendocrine and mTOR pathways are involved in mediating differential dietary responses. This genetic tool greatly facilitates the use of C. elegans as a model for dietary signaling.

  6. Developing Reading Comprehension Modules to Facilitate Reading Comprehension among Malaysian Secondary School ESL Students

    Directory of Open Access Journals (Sweden)

    Muhammad Javed

    2015-07-01

    Full Text Available The study aims to develop a set of 6 Reading Comprehension Modules (RCMs for Malaysian ESL teachers to facilitate different reading abilities of ESL students effectively. Different skill categories were selected for developing the RCMs. This article describes how and why diverse texts of varying length were adopted and adapted from various authentic sources for ESL students having different reading abilities/bands. It also discusses how literal, reorganisation, and inferential questions were constructed appropriately based on the texts selected in the RCMs. Five experienced content/language experts validated the RCMs while eighty ESL students selected through purposive sampling from a secondary school from Penang, Malaysia participated in the pilot study for determining the reliability of the RCMs. The results of the pilot study revealed that the participants improved their scores gradually. Kuder and Richardson Formula 20 (KR-20 was employed to determine the internal consistency of the RCMs. The calculated values of RCMs ranged between 0.804 and 0.923 that indicate high reliability. The RCMs were standardised through a rigorous developmental process by using the Pebble in the Pond Model (Merril, 2002. We hope that the standardised RCMs would act as indicators for the ESL teachers to enhance ESL students’ performance in reading comprehension

  7. Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

    Science.gov (United States)

    Miller, Gregory M; Hsieh-Wilson, Linda C

    2015-12-01

    Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and mature nervous system, where they guide axons, maintain stable connections, restrict synaptic plasticity, and prevent axon regeneration following CNS injury. The chondroitin sulfate glycosaminoglycan (CS GAG) chains that decorate CSPGs are essential for their functions. Through these sugar chains, CSPGs are able to bind and regulate the activity of a diverse range of proteins. CSPGs have been found both to promote and inhibit neuronal growth. They can promote neurite outgrowth by binding to various growth factors such as midkine (MK), pleiotrophin (PTN), brain-derived neurotrophic factor (BDNF) and other neurotrophin family members. CSPGs can also inhibit neuronal growth and limit plasticity by interacting with transmembrane receptors such as protein tyrosine phosphatase σ (PTPσ), leukocyte common antigen-related (LAR) receptor protein tyrosine phosphatase, and the Nogo receptors 1 and 3 (NgR1 and NgR3). These CS-protein interactions depend on specific sulfation patterns within the CS GAG chains, and accordingly, particular CS sulfation motifs are upregulated during development, in the mature nervous system, and in response to CNS injury. Thus, spatiotemporal regulation of CS GAG biosynthesis may provide an important mechanism to control the functions of CSPGs and to modulate intracellular signaling pathways. Here, we will discuss these sulfation-dependent processes and highlight how the CS sugars on CSPGs contribute to neuronal growth, axon guidance, and plasticity in the nervous system. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Dental diagnostic clinical instrument ('Canary') development using photothermal radiometry and modulated luminescence

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, R J; Sivagurunathan, K; Garcia, J; Matvienko, A; Mandelis, A [Center for Advanced Diffusion Wave Technologies (CADIFT), Department of Mechanical and Industrial Engineering, University of Toronto, 5 King' s College Road, Toronto, Ontario, M5S 3G8 (Canada); Abrams, S, E-mail: mandelis@mie.utoronto.c [Quantum Dental Technologies, 748 Briar Hill Avenue, Toronto, Ontario, M6B 1L3 (Canada)

    2010-03-01

    Since 1999, our group at the CADIFT, University of Toronto, has developed the application of Frequency Domain Photothermal Radiometry (PTR) and Luminescence (LUM) to dental caries detection. Various cases including artificial caries detection have been studied and some of the inherent advantages of the adaptation of this technique to dental diagnostics in conjunction with modulated luminescence as a dual-probe technique have been reported. Based on these studies, a portable, compact diagnostic instrument for dental clinic use has been designed, assembled and tested. A semiconductor laser, optical fibers, a thermoelectric cooled mid-IR detector, and a USB connected data acquisition card were used. Software lock-in amplifier techniques were developed to compute amplitude and phase of PTR and LUM signals. In order to achieve fast measurement and acceptable signal-to-noise ratio (SNR) for clinical application, swept sine waveforms were used. As a result sampling and stabilization time for each measurement point was reduced to a few seconds. A sophisticated software interface was designed to simultaneously record intra-oral camera images with PTR and LUM responses. Preliminary results using this instrument during clinical trials in a dental clinic showed this instrument could detect early caries both from PTR and LUM signals.

  9. Zeatin modulates flower bud development and tocopherol levels in Cistus albidus (L.) plants as they age.

    Science.gov (United States)

    Hernández, I; Miret, J A; Van Der Kelen, K; Rombaut, D; Van Breusegem, F; Munné-Bosch, S

    2015-01-01

    In a previous study we showed that Cistus albidus (L.) experiences an age-dependent decay in flower vigour correlated with a decline in trans-zeatin (tZ) levels. In the present study we aimed to establish a causal relationship between these two phenomena. Exogenous tZ applied to plants grown under semi-controlled conditions did not rescue flower vigour; however, it accelerated flower development, but only in younger individuals. Older plants showed lower tocopherol levels in flower buds, which were restored by exogenous tZ, suggesting that a loss of antioxidant defences may underlie the age-dependent decay in flower vigour. We conclude that declining tZ levels may not be directly responsible for the age-associated loss of floral vigour; that tZ modulates the speed of flower development as plants age; and that flower buds alter their sensitivity to tZ as plants age. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  10. Social provocation modulates decision making and feedback processing: Examining the trajectory of development in adolescent participants

    Directory of Open Access Journals (Sweden)

    Hannah L. Pincham

    2015-10-01

    Full Text Available Increasingly, research is turning to the ways in which social context impacts decision making and feedback processing in adolescents. The current study recorded electroencephalography to examine the trajectory of development across adolescence, with a focus on how social context impacts cognition and behaviour. To that end, younger (10–12 years and older (14–16 years adolescents played a modified Taylor Aggression Paradigm against two virtual opponents: a low-provoker and a high-provoker. During the task's decision phase (where participants select punishment for their opponent, we examined two event-related potentials: the N2 and the late positive potential (LPP. During the outcome phase (where participants experience win or loss feedback, we measured the feedback related negativity (FRN. Although N2 amplitudes did not vary with provocation, LPP amplitudes were enhanced under high provocation for the younger group, suggesting that emotional reactivity during the decision phase was heightened for early adolescents. During the outcome phase, the FRN was reduced following win outcomes under high provocation for both groups, suggesting that a highly provocative social opponent may influence the reward response. Collectively, the data argue that social context is an important factor modulating neural responses in adolescent behavioural and brain development.

  11. Development and modulation of intrinsic membrane properties control the temporal precision of auditory brain stem neurons.

    Science.gov (United States)

    Franzen, Delwen L; Gleiss, Sarah A; Berger, Christina; Kümpfbeck, Franziska S; Ammer, Julian J; Felmy, Felix

    2015-01-15

    Passive and active membrane properties determine the voltage responses of neurons. Within the auditory brain stem, refinements in these intrinsic properties during late postnatal development usually generate short integration times and precise action-potential generation. This developmentally acquired temporal precision is crucial for auditory signal processing. How the interactions of these intrinsic properties develop in concert to enable auditory neurons to transfer information with high temporal precision has not yet been elucidated in detail. Here, we show how the developmental interaction of intrinsic membrane parameters generates high firing precision. We performed in vitro recordings from neurons of postnatal days 9-28 in the ventral nucleus of the lateral lemniscus of Mongolian gerbils, an auditory brain stem structure that converts excitatory to inhibitory information with high temporal precision. During this developmental period, the input resistance and capacitance decrease, and action potentials acquire faster kinetics and enhanced precision. Depending on the stimulation time course, the input resistance and capacitance contribute differentially to action-potential thresholds. The decrease in input resistance, however, is sufficient to explain the enhanced action-potential precision. Alterations in passive membrane properties also interact with a developmental change in potassium currents to generate the emergence of the mature firing pattern, characteristic of coincidence-detector neurons. Cholinergic receptor-mediated depolarizations further modulate this intrinsic excitability profile by eliciting changes in the threshold and firing pattern, irrespective of the developmental stage. Thus our findings reveal how intrinsic membrane properties interact developmentally to promote temporally precise information processing.

  12. Development of Power Supply Management Module for Radio Signal Repeaters of Automatic Metering Reading System in Variable Solar Density Conditions

    Directory of Open Access Journals (Sweden)

    Kondratjevs K.

    2016-02-01

    Full Text Available In recent years, there has been significant research focus that revolves around harvesting and minimising energy consumption by wireless sensor network nodes. When a sensor node is depleted of energy, it becomes unresponsive and disconnected from the network that can significantly influence the performance of the whole network. The purpose of the present research is to create a power supply management module in order to provide stable operating voltage for autonomous operations of radio signal repeaters, sensors or gateways of WSN. The developed management module is composed of a solar panel, lithium battery and power supply management module. The novelty of the research is the management module, which ensures stable and uninterrupted operations of electronic equipment in various power supply modes in different situations, simultaneously ensuring energy protection and sustainability of the module components. The management module is able to provide power supply of 5 V for electronics scheme independently, without power interruption switching between power sources and power flows in different directions.

  13. Principles of Practical Training Organization in a Networking (Development of the Module "Psychological Prevention of Behavioral Disorders and Abnormalities in Development" as Example

    Directory of Open Access Journals (Sweden)

    Bogdanovich N. V.

    2016-01-01

    Full Text Available The article presents principles of inserting study subjects and practices in educational modules running with network organizations (internship sites. We proposed a methodological basis of the modular organization of educational process in the framework of the master's program, combied the activity, competence and psychotechnical approaches. Networking of leading chair and specially selected organizations providing the base for practical training solves the problem of organizing activity-related content of educational module. We discussed the main options for networking with the databases of practice and offered methodological principles of designing the educational practice-oriented module, wherein the main principle is the reflexive and activity character of networking. We proposed activity-based content of educational module "Psychological prevention of behavioral disorders and abnormalities in development", based on the substantial psychological definition of psychoprophylaxis as a directions of professional activity of the psychologist.

  14. Development of Prototype Outcomes-Based Training Modules for Aesthetic Dentistry

    Science.gov (United States)

    Andres, Maricar Joy T.; Borabo, Milagros L.

    2015-01-01

    The objective of the study is to know the essential components of Aesthetic Dentistry that will be a basis for prototype Outcomes-based training modules. Using a 5-point Likert scale, the researcher-made questionnaire assessed the different elements of Aesthetic Dentistry which are needed in the designing of the training module, the manner of…

  15. Development of a new lower hybrid antenna module using a poloidal power divider

    Energy Technology Data Exchange (ETDEWEB)

    Maebara, S.; Imai, T.; Seki, M.; Suganuma, K. [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Goniche, M.; Bibet, Ph.; Berio, S.; Brossaud, J.; Rey, G.; Tonon, G. [Association Euratom-CEA, Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    1997-03-01

    A realistic antenna module using a poloidal divider for lower hybrid current drive (LHCD) experiment, is modelled and fabricated. In this antenna module test II, three types of poloidal dividers, which split the power in 3, are tested. (author). 15 refs.

  16. Development of modulation strategies for NPC converter addressing DC link voltage balancing and CMV reduction

    DEFF Research Database (Denmark)

    Boian, D.; Biris, C.; Teodorescu, Remus

    2012-01-01

    in insulation breakdown and bearing failures. By the use of this type of converters, both Electromagnetic Interference (EMI) and harmonic distortions are improved. This paper proposes two modulation strategies for Three Level Neutral Point Clamped Converter (3L-NPC). The main focus of these modulation...... strategies is to reduce the Common Mode Voltage (CMV) and balance the DC Link Voltage....

  17. Engineering study, development and prototype fabrication of the supporting system for the CLIC Two-Beam Module

    CERN Document Server

    AUTHOR|(CDS)2068725; Karyotakis, Yannis; Dahoo, Pierre Richard; Alexopoulos, Theo; MEIS, Costantin; De Conto, Jean Marie; Jeremie, Andrea; Puzot, Patrique

    CERN, the European Organization for Nuclear Research, is based on the international collaboration in the field of high-energy particle physics research. The experiments carried out in its facilities are achieved through the existing particle accelerators. In addition, advanced accelerator research and development is one of the goals of CERN. For this reason, CLIC (the Compact LInear Collider) a new electron-positron linear accelerator is being studied at CERN. CLIC is built by the assembly of the Two-Beam Modules and takes advantage of an innovative acceleration principle, the Two-Beam acceleration. Each Module contains several technical systems that contribute to its successful operation. This thesis presents the development of the prototype supporting system for the CLIC Two-Beam Module. At first, the physics requirements are translated into technical specifications and the fundamental parts of the supporting system are defined. The CLIC operational conditions are identified and the corresponding boundaries...

  18. Twenty-Channel Voice Response System.

    Science.gov (United States)

    1981-06-01

    programs and vocabulary. 0 Telephone Company (TELCO) Switched Lines - provides access to VRS using telephones. * Bell 407C Data Sets - Converts the Touch...from the twenty 407C units. 0 DLII-E - Asynchronous interface to the 11/34 unibus for the VOTRAX unit. * 20 Channel ADPCM Decoder - a specially designed

  19. Educating the Ablest: Twenty Years Later

    Science.gov (United States)

    Culross, Rita R.

    2015-01-01

    This study examines the current lives of thirty-five individuals who participated in high school gifted programs twenty years ago. The research specifically looked at educational attainment and career goals in terms of expressed aspirations in high school, using social media and other Internet sources. Results indicated continued support for the…

  20. Development and validation of the spondyloarthritis radiography module for calibration of readers using the modified Stoke Ankylosing Spondylitis Spine Score.

    Science.gov (United States)

    Maksymowych, Walter P; Learch, Thomas; Lambert, Robert G; Ward, Michael; Haroon, Nigil; Inman, Robert; Salonen, David; Gensler, Lianne S; Weisman, Michael H

    2014-01-01

    To develop and validate a reference image module aimed at calibration of readers using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) to assess radiographic progression in spondyloarthritis. Our working group comprised 6 rheumatologists and 3 musculoskeletal radiologists. The following developmental steps were conducted: (1) review of the literature to identify aspects of the mSASSS requiring methodologic clarity; (2) independent assessment of baseline and 2-year radiographs from 25 patients using the mSASSS (pilot exercise); (3) development of a training module (the Spondyloarthritis Radiography [SPAR] module) that clarifies definitions, rules, and scoring methodology and a set of reference radiographic images; (4) scoring exercise 1 by 6 readers on 39 patients, where baseline and 2-year radiographs were scored blinded to time point; and (5) revision of the SPAR module followed by scoring exercise 2 conducted by the same 6 readers on 35 patients. Reliability of status and 2-year change scores was assessed by the intraclass correlation coefficient (ICC) method. ICCs for change scores for the radiologist reader pair improved from 0.46 to 0.62 after minimal calibration with the SPAR module. Recalibration from exercise 1 to exercise 2 with the SPAR module led to substantial improvement in interreader reliability for change in mSASSS score from ICC 0.44 (range 0.31-0.62) to ICC 0.62 (range 0.34-0.84). Simultaneous assessment of anteroposterior and lateral lumbar radiographs did not enhance reliability or detection of progression. Calibration according to the SPAR module led to improved reliability in the scoring of the mSASSS, even for expert readers. Copyright © 2014 by the American College of Rheumatology.

  1. Teaching dental students to interact with survivors of traumatic events: development of a two-day module.

    Science.gov (United States)

    Raja, Sheela; Rajagopalan, Chelsea F; Kruthoff, Mariela; Kuperschmidt, Alexandra; Chang, Priscilla; Hoersch, Michelle

    2015-01-01

    Dentists are likely to treat patients who have experienced a wide range of traumatic life events, including child abuse and neglect, domestic violence, sexual assault, elder abuse, and exposure to combat. In order to effectively treat survivors of traumatic events, dentists must understand how these patients may present in oral health settings, the basic mandated reporting requirements related to abuse and neglect, and communication strategies to help engage trauma survivors in dental treatment. A traditional lecture-format educational module on trauma-informed care was developed and implemented for second-year dental students (N=92) at one U.S. dental school, after which a needs assessment was performed (all 92 students participated). This assessment then informed development of an enhanced module for the subsequent group of second-year dental students (N=102) at the same school. The revised (final) module was more interactive in nature, expanded to multiple sessions, and included more discussion of mandated reporting and appropriate dentist-patient communication in relation to traumatic events. All 102 students participated in assessments of the revised module. Comparison of pre and post tests and needs assessments between the initial and final modules indicated that the extended, more interactive final module was more effective in meeting the educational objectives. Results showed that the final module increased the students' knowledge in the health-related manifestations of traumatic events and slightly improved their confidence levels in treating survivors of trauma. Dentists who are prepared to deliver trauma-informed care may help individual patients feel more at ease and increase engagement in regular preventive care. Suggestions for future educational efforts in this area are discussed.

  2. The development and testing of a unique and flexible training module for residents and fellows using digital breast tomosythesis (DBT)

    Science.gov (United States)

    Hakim, Christiane M.; Drescher, John; King, Jill L.; Logue, Durwin; Klym, Amy H.; Gur, David

    2017-03-01

    The transition from FFDM to digital breast tomosynthesis (DBT) necessitates new approaches for training radiology residents and fellows that highlight depiction differences between the same abnormalities on the two modalities. We developed a unique, flexible training module that enables training with complete feedback, as well as testing performance before and after use of this training module. Currently, 219 examinations, with priors and other relevant information, are included. Using a special interface to the Secure View workstation (Hologic), we developed a management program that displays each case in a randomized manner and in a sequential mode (i.e. FFDM first followed by FFDM+DBT) and allows the reader to rate the case followed by viewing the images side by side with results of the full imaging based history (reporting) by the screening interpreter, the diagnostic workup interpreter (when applicable), and the actual pathology (biopsy and/or surgical). This approach allows the reader to review their correct and/or incorrect interpretation at each step of the management decision making. The module also has sets of pre- and post-training cases, allowing for a test-train-test study to be performed, if so desired. Two observer studies using 18 radiologists, residents, and fellows have been performed using this module, to date. The training module was assembled, tested, and implemented. We found it to be extremely flexible and useful in training. After completing two observer performance studies, the module was installed in our clinical facility and is currently being used to train residents and fellows at their own pace. All users found this module to be useful and extremely informative.

  3. Development of “OQALE” Based Reference Module for School Geometry Subject and Analysis of Mathematical Creative Thinking Skills

    Science.gov (United States)

    Wulandari, N. A. D.; Sukestiyarno, Y. L.

    2017-04-01

    This research aims to develop an OQALE based reference module for school geometry subject that meets the criteria of a valid and practical. OQALE approach is learning by of O = observation, Q = question, A = Analyze, L = Logic, E = Express. Geometry subject presented in the module are a triangle, the Pythagorean theorem, and rectangular. Mathematical skills of creative thinking shown from four aspects: fluency, flexibility, originality and elaboration. Research procedures in the development of reference module using a strategy of the investigation and development described by [2], which is limited to the sixth stage is leading field testing. The focus of this research is to develop a reference module that is valid, practical and able to increase the mathematical creative thinking skills of students. The testing is limited to three teachers, nine students and two mathematic readers using purposive sampling technique. The data validity, practicality, and creative thinking skills upgrading collected through questionnaires, observations, and interviews and analysed with a valid test, practical test, gain test and qualitative descriptive. The results were obtained (1) the validity of the module = 4.52, which is 4.20 ≤ Vm< 5.00 included in the category of very valid; (2) the results of the questionnaire responses of teachers = 4.53, which is 4.20 ≤ Rg< 5.00 included in the category of very good; (3) the results of the survey responses of students = 3.13, which is 2.80 ≤ Rpd< 3.40 included in the category of good with an average percentage of 78%; and (4) increasing skills of creative thinking mathematically nine students through the test of the gain included in the high and medium category. The conclusions of this research are the generated OQALE based reference module for school geometry subjectis valid and practical.

  4. Dioxin modulates expression of receptor for activated C kinase (RACK-1) in developing neurons

    Energy Technology Data Exchange (ETDEWEB)

    Yang, J.H.; Kim, S.Y.; Lee, H.G.; Kim, M.Y.; Lee, J.H.; Chae, W.G. [Catholic Univ. of Daegu, Dept. of Pharmacology/Toxicology, Daegu (Korea)

    2004-09-15

    TCDD is sensitive to the central nerve system of the developing brain. The TCDD-induced neurodevelopmental deficits include the cognitive disability and motor dysfunction. While TCDD may lead to neurodevelopmental and neurobehavioral deficit, it is not known which molecular substances are intracellular targets for TCDD. Since TCDD accumulates in brain and the brain contains the Ah receptor, it is possible that TCDD may act at the target site such as cerebellum, which is responsible for cognitive abilities and motor function. A recent in vitro studies using cerebellar granule cells demonstrated a translocation of PKC-{alpha} and {epsilon} following the TCDD or PCB exposure. One of the most pivotal second messenger molecules involved in neuronal function and development is protein kinase C (PKC). PKC signaling pathways have been implicated as an important factor in learning and memory processes. PKC signaling events are optimized by the adaptor proteins, which organize PKCs near their selective substrates and away from others. RACK-1(receptor for activated C-kinase) is one of adaptor proteins that anchor the activated PKC at the site of translocation 6. RACKs bind PKC only in the presence of PKC activators. RACKs are 30- and 36-kDa proteins located in cytoskeletal compartment and play a key role in PKC activation and in membrane amchoring. Since different PKC isoforms translocate to distinct subcellular sites on activation, it is suggested that isoform-specific RACK may be present. Activation of certain PKC isoforms (PKC-a and {beta}II) is preferentially associated with RACK-1. While TCDD modulates PKC signaling pathway, role of RACK-1 on TCDD-mediated signaling pathway is not known. To identify the intracellular target for TCDD and understand a mechanism of signaling pathway in the developing brain, the present study attempted to analyze effects of RACK-1 in the cerebellar granule cells following TCDD exposure.

  5. Modulation of GABAergic Transmission in Development and Neurodevelopmental Disorders: Investigating Physiology and Pathology to Gain Therapeutic Perspectives

    Directory of Open Access Journals (Sweden)

    Gabriele eDeidda

    2014-05-01

    Full Text Available During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of neuronal networks. In neuronal development, GABAergic signaling regulates neural proliferation, migration, differentiation, and neuronal-network wiring. In the adult, GABA orchestrates the activity of different neuronal cell-types largely interconnected, by powerfully modulating synaptic activity. GABA exerts these functions by binding to chloride-permeable ionotropic GABAA receptors and metabotropic GABAB receptors. According to its functional importance during development, GABA is implicated in a number of neurodevelopmental disorders such as autism, Fragile X, Rett syndrome, Down syndrome, schizophrenia, Tourette's syndrome and neurofibromatosis.The strength and polarity of GABAergic transmission is continuously modulated during physiological, but also pathological conditions. For GABAergic transmission through GABAA receptors, strength regulation is achieved by different mechanisms such as modulation of GABAA receptors themselves, variation of intracellular chloride concentration, and alteration in GABA metabolism. In the never-ending effort to find possible treatments for GABA-related neurological diseases, of great importance would be modulating GABAergic transmission in a safe and possibly physiological way, without the dangers of either silencing network activity or causing epileptic seizures. In this review, we will discuss the different ways to modulate GABAergic transmission normally at work both during physiological and pathological conditions. Our aim is to highlight new research perspectives for therapeutic treatments that reinstate natural and physiological brain functions in neuro-pathological conditions.

  6. Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors.

    Science.gov (United States)

    Guxens, Mònica; Aguilera, Inmaculada; Ballester, Ferran; Estarlich, Marisa; Fernández-Somoano, Ana; Lertxundi, Aitana; Lertxundi, Nerea; Mendez, Michelle A; Tardón, Adonina; Vrijheid, Martine; Sunyer, Jordi

    2012-01-01

    Air pollution effects on children's neurodevelopment have recently been suggested to occur most likely through the oxidative stress pathway. We aimed to assess whether prenatal exposure to residential air pollution is associated with impaired infant mental development, and whether antioxidant/detoxification factors modulate this association. In the Spanish INfancia y Medio Ambiente (INMA; Environment and Childhood) Project, 2,644 pregnant women were recruited during their first trimester. Nitrogen dioxide (NO2) and benzene were measured with passive samplers covering the study areas. Land use regression models were developed for each pollutant to predict average outdoor air pollution levels for the entire pregnancy at each residential address. Maternal diet was obtained at first trimester through a validated food frequency questionnaire. Around 14 months, infant mental development was assessed using Bayley Scales of Infant Development. Among the 1,889 children included in the analysis, mean exposure during pregnancy was 29.0 μg/m3 for NO2 and 1.5 μg/m3 for benzene. Exposure to NO2 and benzene showed an inverse association with mental development, although not statistically significant, after adjusting for potential confounders [β (95% confidence interval) = -0.95 (-3.90, 1.89) and -1.57 (-3.69, 0.56), respectively, for a doubling of each compound]. Stronger inverse associations were estimated for both pollutants among infants whose mothers reported low intakes of fruits/vegetables during pregnancy [-4.13 (-7.06, -1.21) and -4.37 (-6.89, -1.86) for NO2 and benzene, respectively], with little evidence of associations in the high-intake group (interaction p-values of 0.073 and 0.047). Inverse associations were also stronger in non-breast-fed infants and infants with low maternal vitamin D, but effect estimates and interactions were not significant. Our findings suggest that prenatal exposure to residential air pollutants may adversely affect infant mental

  7. Development, implementation and evaluation of a terminal and hospice care educational online module for preclinical students.

    Science.gov (United States)

    Tse, Chung Sang; Ellman, Matthew S

    2017-03-01

    To explore the application of an online learning tool to teach preclinical medical students terminal and hospice care in a blended curricula. We created and evaluated a 30 min interactive online module at the Yale School of Medicine. Second-year medical students were randomly assigned to complete the online module or not (control group) prior to attending a required half-day hospice clinical experience. We assessed the students' knowledge and attitudes with a 23-item survey. 152 students (response rate 51%) participated in this study from 2012 to 2014. 56% (n=85) completed the online module, 37% (n=56) did not and 7% (n=11) did not indicate whether they had completed the module or not. Students who completed the online module prior to the hospice experience scored higher (peducation is important in medical school. When combined with a mentored clinical hospice experience, an online module appears to enhance the teaching of the dying process and terminal care for preclinical medical students. This online module may prove useful for other institutions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  8. APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.

    Science.gov (United States)

    Ewald, Collin Y; Raps, Daniel A; Li, Chris

    2012-06-01

    Mutations in the amyloid precursor protein (APP) gene or in genes that process APP are correlated with familial Alzheimer's disease (AD). The biological function of APP remains unclear. APP is a transmembrane protein that can be sequentially cleaved by different secretases to yield multiple fragments, which can potentially act as signaling molecules. Caenorhabditis elegans encodes one APP-related protein, APL-1, which is essential for viability. Here, we show that APL-1 signaling is dependent on the activity of the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12 and influences metabolic pathways such as developmental progression, body size, and egg-laying rate. Furthermore, apl-1(yn5) mutants, which produce high levels of the extracellular APL-1 fragment, show an incompletely penetrant temperature-sensitive embryonic lethality. In a genetic screen to isolate mutants in which the apl-1(yn5) lethality rate is modified, we identified a suppressor mutation in MOA-1/R155.2, a receptor-protein tyrosine phosphatase, and an enhancer mutation in MOA-2/B0495.6, a protein involved in receptor-mediated endocytosis. Knockdown of apl-1 in an apl-1(yn5) background caused lethality and molting defects at all larval stages, suggesting that apl-1 is required for each transitional molt. We suggest that signaling of the released APL-1 fragment modulates multiple metabolic states and that APL-1 is required throughout development.

  9. Modeling the Exo-Brake and the Development of Strategies for De-Orbit Drag Modulation

    Science.gov (United States)

    Murbach, M. S.; Papadopoulos, P.; Glass, C.; Dwyer-Cianciolo, A.; Powell, R. W.; Dutta, S.; Guarneros-Luna, A.; Tanner, F. A.; Dono, A.

    2016-01-01

    The Exo-Brake is a simple, non-propulsive means of de-orbiting small payloads from orbital platforms such as the International Space Station (ISS). Two de-orbiting experiments with fixed surface area Exo-Brakes have been successfully conducted in the last two years on the TechEdSat-3 and -4 nano-satellite missions. The development of the free molecular flow aerodynamic data-base is presented in terms of angle of attack, projected front surface area variation, and altitude. Altitudes are considered ranging from the 400km ISS jettison altitude to 90km. Trajectory tools are then used to predict de-orbit/entry corridors with the inclusion of the key atmospheric and geomagnetic uncertainties. Control system strategies are discussed which will be applied to the next two planned TechEdSat-5 and -6 nano-satellite missions - thus increasing the targeting accuracy at the Von Karman altitude through the proposed drag modulation technique.

  10. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development.

    Science.gov (United States)

    Knopp, Matthias Manne; Löbmann, Korbinian; Elder, David P; Rades, Thomas; Holm, René

    2016-05-25

    Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist.

  11. Development and evaluation of study guide template for an integrated cardiovascular module.

    Science.gov (United States)

    Al-Hazimi, Awdah

    2012-01-01

    The undergraduate medical curriculum in the King Abdulaziz University in Jeddah, Saudi Arabia, was reformed in 2002. It is integrated, organized in courses and modules, and has an increasing proportion of problem-based and self-directed learning. The new curriculum has presented the faculty and students with specific challenges. Accustomed to a traditional teacher-centred approach, and because the language of instruction is English, students needed much more support and encouragement in taking advantages of independent learning than their western counterparts would require. A well-designed study guide may be more effective student learning tool in the new integrated curriculum. This article describes to simplify and modern approach to the production of study guides. The approach is based on the development and the use of a study guide template. The guide is evaluated by second year medical students at King Abdulaziz University. The study guide is highly appreciated by student evaluations and 'study guide template' that includes a well-designed layout is a useful aid for medical teachers who have had no experience in producing a study guide. The template allows medical teachers to invest their time in the production of the content rather than in the layout and format of the guide.

  12. Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library.

    Science.gov (United States)

    Bai, Renren; Shi, Qi; Liang, Zhongxing; Yoon, Younghyoun; Han, Yiran; Feng, Amber; Liu, Shuangping; Oum, Yoonhyeun; Yun, C Chris; Shim, Hyunsuk

    2017-01-27

    CXCR4 plays a crucial role in recruitment of inflammatory cells to inflammation sites at the beginning of the disease process. Modulating CXCR4 functions presents a new avenue for anti-inflammatory strategies. However, using CXCR4 antagonists for a long term usage presents potential serious side effect due to their stem cell mobilizing property. We have been developing partial CXCR4 antagonists without such property. A new computer-aided drug design program, the FRESH workflow, was used for anti-CXCR4 lead compound discovery and optimization, which coupled both compound library building and CXCR4 docking screens in one campaign. Based on the designed parent framework, 30 prioritized amide-sulfamide structures were obtained after systemic filtering and docking screening. Twelve compounds were prepared from the top-30 list. Most synthesized compounds exhibited good to excellent binding affinity to CXCR4. Compounds Ig and Im demonstrated notable in vivo suppressive activity against xylene-induced mouse ear inflammation (with 56% and 54% inhibition). Western blot analyses revealed that Ig significantly blocked CXCR4/CXCL12-mediated phosphorylation of Akt. Moreover, Ig attenuated the amount of TNF-α secreted by pathogenic E. coli-infected macrophages. More importantly, Ig had no observable cytotoxicity. Our results demonstrated that FRESH virtual high throughput screening program of targeted chemical class could successfully find potent lead compounds, and the amide-sulfamide pharmacophore was a novel and effective framework blocking CXCR4 function.

  13. Development of InGaAsSb Based Monolithic Interconnected Modules (MIMs)

    Science.gov (United States)

    Palmisiano, M. N.; Biefeld, R. M.; Cederberg, J. G.; Hafich, M. J.; Peake, G. M.

    2003-01-01

    The quaternary Sb-based materials are attractive for use in TPV devices due to the versatility associated with being able to grow InGaAsSb and AlGaAsSb material with a wide range of band gaps lattice matched to a GaSb substrate. Photodiodes (0.60 eV) consisting of an InGaAsSb p/n junction grown on GaSb were fabricated and characterized to establish baseline electrical performance of the material. In order to fabricate monolithic interconnected modules (MIMs) from these photodiodes using a conductive GaSb substrate, an electrical isolation layer must be added between the active layers and the substrate. For this purpose, AlGaAsSb cell isolation diodes (CIDs) were developed and characterized with respect to their ability to block current in reverse bias. These structures were combined in the first MIM structures grown and fabricated from Sb-based materials on GaSb substrates.

  14. Modeling anterior development in mice: diet as modulator of risk for neural tube defects.

    Science.gov (United States)

    Kappen, Claudia

    2013-11-01

    Head morphogenesis is a complex process that is controlled by multiple signaling centers. The most common defects of cranial development are craniofacial defects, such as cleft lip and cleft palate, and neural tube defects, such as anencephaly and encephalocoele in humans. More than 400 genes that contribute to proper neural tube closure have been identified in experimental animals, but only very few causative gene mutations have been identified in humans, supporting the notion that environmental influences are critical. The intrauterine environment is influenced by maternal nutrition, and hence, maternal diet can modulate the risk for cranial and neural tube defects. This article reviews recent progress toward a better understanding of nutrients during pregnancy, with particular focus on mouse models for defective neural tube closure. At least four major patterns of nutrient responses are apparent, suggesting that multiple pathways are involved in the response, and likely in the underlying pathogenesis of the defects. Folic acid has been the most widely studied nutrient, and the diverse responses of the mouse models to folic acid supplementation indicate that folic acid is not universally beneficial, but that the effect is dependent on genetic configuration. If this is the case for other nutrients as well, efforts to prevent neural tube defects with nutritional supplementation may need to become more specifically targeted than previously appreciated. Mouse models are indispensable for a better understanding of nutrient-gene interactions in normal pregnancies, as well as in those affected by metabolic diseases, such as diabetes and obesity.

  15. DEVELOPMENT OF PRESSURIZED CIRCULATIONG FLUIDIZED BED PARTIAL GASIFICATION MODULE(PGM)

    Energy Technology Data Exchange (ETDEWEB)

    Archie Robertson

    2003-04-17

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building block that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the January 1--March 31, 2003 time period.

  16. Modeling development and quantitative trait mapping reveal independent genetic modules for leaf size and shape.

    Science.gov (United States)

    Baker, Robert L; Leong, Wen Fung; Brock, Marcus T; Markelz, R J Cody; Covington, Michael F; Devisetty, Upendra K; Edwards, Christine E; Maloof, Julin; Welch, Stephen; Weinig, Cynthia

    2015-10-01

    Improved predictions of fitness and yield may be obtained by characterizing the genetic controls and environmental dependencies of organismal ontogeny. Elucidating the shape of growth curves may reveal novel genetic controls that single-time-point (STP) analyses do not because, in theory, infinite numbers of growth curves can result in the same final measurement. We measured leaf lengths and widths in Brassica rapa recombinant inbred lines (RILs) throughout ontogeny. We modeled leaf growth and allometry as function valued traits (FVT), and examined genetic correlations between these traits and aspects of phenology, physiology, circadian rhythms and fitness. We used RNA-seq to construct a SNP linkage map and mapped trait quantitative trait loci (QTL). We found genetic trade-offs between leaf size and growth rate FVT and uncovered differences in genotypic and QTL correlations involving FVT vs STPs. We identified leaf shape (allometry) as a genetic module independent of length and width and identified selection on FVT parameters of development. Leaf shape is associated with venation features that affect desiccation resistance. The genetic independence of leaf shape from other leaf traits may therefore enable crop optimization in leaf shape without negative effects on traits such as size, growth rate, duration or gas exchange.

  17. Development of the VESUVIUS module. Molten jet breakup modeling and model verification

    Energy Technology Data Exchange (ETDEWEB)

    Vierow, K. [Nuclear Power Engineering Corp., Tokyo (Japan); Nagano, Katsuhiro; Araki, Kazuhiro

    1998-01-01

    With the in-vessel vapor explosion issue ({alpha}-mode failure) now considered to pose an acceptably small risk to the safety of a light water reactor, ex-vessel vapor explosions are being given considerable attention. Attempts are being made to analytically model breakup of continuous-phase jets, however uncertainty exists regarding the basic phenomena. In addition, the conditions upon reactor vessel failure, which determine the starting point of the ex-vessel vapor explosion process, are difficult to quantify. Herein, molten jet ejection from the reactor pressure vessel is characterized. Next, the expected mode of jet breakup is determined and the current state of analytical modeling is reviewed. A jet breakup model for ex-vessel scenarios, with the primary breakup mechanism being the Kelvin-Helmholtz instability, is described. The model has been incorporated into the VESUVIUS module and comparisons of VESUVIUS calculations against FARO L-06 experimental data show differences, particularly in the pressure curve and amount of jet breakup. The need for additional development to resolve these differences is discussed. (author)

  18. NC Material Management Module Development%NC系统物料管理模块开发

    Institute of Scientific and Technical Information of China (English)

    梁卫东

    2012-01-01

    介绍如何系统化地进行有线电视的物料管理,并通过对NC供应链系统物料管理模块的开发,利用财务结算的材料费用和仓库管理的材料数量,应用到规划建设的物料管理上,从而实现有线电视工程预算与财务结算数据的对接,更有效地把控工程材料用量,提高了工程物料管理工作的效率。%This paper introduces how to systematically cable material management, and through the NC supply chain system material management module development, the financial settlement of material cost and ware- house management quantity of material, applied to the planning and construction material management. In or- der to achieve CATV project budget and financial settlement data docking, more effectively to control the engi- neering material, for complicated engineering materials management to improve efficiency.

  19. Integrating Anatomy Training into Radiation Oncology Residency: Considerations for Developing a Multidisciplinary, Interactive Learning Module for Adult Learners

    Science.gov (United States)

    Labranche, Leah; Johnson, Marjorie; Palma, David; D'Souza, Leah; Jaswal, Jasbir

    2015-01-01

    Radiation oncologists require an in-depth understanding of anatomical relationships for modern clinical practice, although most do not receive formal anatomy training during residency. To fulfill the need for instruction in relevant anatomy, a series of four multidisciplinary, interactive learning modules were developed for a cohort of radiation…

  20. "Module 9": A New Course to Help Students Develop Interdisciplinary Projects Using the Framework of Experiential Learning Theory

    Science.gov (United States)

    Canboy, Basak; Montalvo, Adolfo; Buganza, M. Carmen; Emmerling, Robert J.

    2016-01-01

    This paper offers an example of how to introduce student-centred knowledge creation and competency development in a systematic way into a master's programme. The curriculum of a new course called Module 9 was framed according to experiential learning theory. While student teams work on self-selected projects, their learning processes are…

  1. Development of Health Education Learning Module in Bac.TSE-LDPE Programme in TTI: Needs Analysis Study

    Science.gov (United States)

    Ujang, Alijah; Alias, Norlidah; Siraj, Saedah

    2015-01-01

    This study is to explore the need to develop learning modules of health education for trainee teachers in the Bachelor Of Teaching (Hons)(Special Education-Learning Disabilities For Primary Education) Programme (Bac.TSE-LDPE) in the Teacher Training Institute (TTI). The questionnaire uses the Likert scale with the close ended questions analysed by…

  2. Developing Algebra Structure Module and Model of Cooperative Learning Helping Concept Map Media for Improving Proofing Ability

    Science.gov (United States)

    Syafari

    2017-01-01

    This research was purposed to develop module and learning model and instrument of proofing ability in algebra structure through cooperative learning with helping map concept media for students of mathematic major and mathematics education in State University and Private University in North Sumatra province. The subject of this research was the…

  3. Development and testing of thermal energy storage modules for use in active solar heating and cooling systems

    Science.gov (United States)

    Parker, J. C.

    1981-04-01

    The project development requirements and criteria are presented along with technical data for the modules. Performance tests included: ducting, temperature, pressure and air flow measurements, dry and wet bulb temperature; duct pressure measurements; and air conditioning apparatus checks; installation, operation, and maintenance instructions are included.

  4. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

    Directory of Open Access Journals (Sweden)

    Magali Roques

    2015-11-01

    Full Text Available Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs. Cyclins are very well characterised in model systems such as yeast and human cells, but surprisingly little is known about their number and role in Plasmodium, the unicellular protozoan parasite that causes malaria. Malaria parasite cell division and proliferation differs from that of many eukaryotes. During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites in host liver and red blood cells, and sporogony (producing sporozoites in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown. We show here that the Plasmodium genome contains only three cyclin genes, representing an unusual repertoire of cyclin classes. Expression and reverse genetic analyses of the single Plant (P-type cyclin, CYC3, in the rodent malaria parasite, Plasmodium berghei, revealed a cytoplasmic and nuclear location of the GFP-tagged protein throughout the lifecycle. Deletion of cyc3 resulted in defects in size, number and growth of oocysts, with abnormalities in budding and sporozoite formation. Furthermore, global transcript analysis of the cyc3-deleted and wild type parasites at gametocyte and ookinete stages identified differentially expressed genes required for signalling, invasion and oocyst development. Collectively these data suggest that cyc3 modulates oocyst endomitotic development in Plasmodium berghei.

  5. Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form.

    Science.gov (United States)

    Newman, Stuart A; Bhat, Ramray

    2009-01-01

    This article considers the role played by a core set of "dynamical patterning modules" (DPMs) in the origination, development and evolution of complex organisms. These consist of the products of a subset of the genes of what has come to be known as the "developmental-genetic toolkit" in association with physical processes they mobilize. The physical processes are those characteristic of chemically and mechanically excitable mesoscopic systems like cell aggregates: cohesion, viscoelasticity, diffusion, spatiotemporal heterogeneity based on activator-inhibitor interaction, and multistable and oscillatory dynamics. We focus on the emergence of the Metazoa, and show how toolkit gene products and pathways that pre-existed the metazoans acquired novel morphogenetic functions simply by virtue of the change in scale and context inherent to multicellularity. We propose that DPMs, acting singly and in combination with each other, constitute a "pattern language" capable of generating all metazoan body plans and organ forms. This concept implies that the multicellular organisms of the late Precambrian-early Cambrian were phenotypically plastic, fluently exploring morphospace in a fashion decoupled from both function-based selection and genotypic change. The relatively stable developmental trajectories and morphological phenotypes of modern organisms, then, are considered to be products of stabilizing selection. This perspective solves the apparent "molecular homology-analogy paradox," whereby widely divergent modern animal types utilize the same molecular toolkit during development, but it does so by inverting the neo-Darwinian principle that phenotypic disparity was generated over long periods of time in concert with, and in proportion to genotypic change.

  6. Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.

    Science.gov (United States)

    Perälä, Nina; Jakobson, Madis; Ola, Roxana; Fazzari, Pietro; Penachioni, Junia Y; Nymark, Mariann; Tanninen, Tiina; Immonen, Tiina; Tamagnone, Luca; Sariola, Hannu

    2011-02-01

    Semaphorins, originally identified as axon guidance molecules, have also been implicated in angiogenesis, function of the immune system and cancerous growth. Here we show that deletion of Plexin B2 (Plxnb2), a semaphorin receptor that is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney, results in renal hypoplasia and occasional double ureters. The rate of cell proliferation in the ureteric epithelium and consequently the number of ureteric tips are reduced in the kidneys lacking Plexin B2 (Plxnb2-/-). Semaphorin 4C, a ligand for Plexin B2, stimulates branching of the ureteric epithelium in wild type and Plxnb2+/- kidney explants, but not in Plxnb2-/- explants. As shown by co-immunoprecipitation Plexin B2 interacts with the Ret receptor tyrosine kinase, the receptor of Glial-cell-line-derived neurotrophic factor (Gdnf), in embryonic kidneys. Isolated Plxnb2-/- ureteric buds fail to respond to Gdnf by branching, but this response is rescued by Fibroblast growth factor 7 and Follistatin as well as by the metanephric mesenchyme. The differentiation of the nephrogenic mesenchyme, its morphology and the rate of apoptosis in the Plxnb2-/- kidneys are normal. Plexin B2 is co-expressed with Plexin B1 (Plxnb1) in the kidney. The double homozygous Plxnb1-Plxnb2-deficient mice show high embryonic lethality prior to onset of nephrogenesis. The only double homozygous embryo surviving to E12 showed hypoplastic kidneys with ureteric branches and differentiating mesenchyme. Taken together, our results show that Sema4C-Plexin B2 signalling regulates ureteric branching, possibly through modulation of Gdnf signalling by interaction with Ret, and suggest non-redundant roles for Plexin B1 and Plexin B2 in kidney development. Copyright © 2010 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

  7. IGF2 DNA methylation is a modulator of newborn's fetal growth and development.

    Science.gov (United States)

    St-Pierre, Julie; Hivert, Marie-France; Perron, Patrice; Poirier, Paul; Guay, Simon-Pierre; Brisson, Diane; Bouchard, Luigi

    2012-10-01

    The insulin-like growth factor 2 (IGF2) gene, located within a cluster of imprinted genes on chromosome 11p15, encodes a fetal and placental growth factor affecting birth weight. DNA methylation variability at the IGF2 gene locus has been previously reported but its consequences on fetal growth and development are still mostly unknown in normal pediatric population. We collected one hundred placenta biopsies from 50 women with corresponding maternal and cord blood samples and measured anthropometric indices, blood pressure and metabolic phenotypes using standardized procedures. IGF2/H19 DNA methylation and IGF2 circulating levels were assessed using sodium bisulfite pyrosequencing and ELISA, respectively. Placental IGF2 (DMR0 and DMR2) DNA methylation levels were correlated with newborn's fetal growth indices, such as weight, and with maternal IGF2 circulating concentration at the third trimester of pregnancy, whereas H19 (DMR) DNA methylation levels were correlated with IGF2 levels in cord blood. The maternal genotype of a known IGF2/H19 polymorphism (rs2107425) was associated with birth weight. Taken together, we showed that IGF2/H19 epigenotype and genotypes independently account for 31% of the newborn's weight variance. No association was observed with maternal diabetic status, glucose concentrations or prenatal maternal body mass index. This is the first study showing that DNA methylation at the IGF2/H19 genes locus may act as a modulator of IGF2 newborn's fetal growth and development within normal range. IGF2/H19 DNA methylation could represent a cornerstone in linking birth weight and fetal metabolic programming of late onset obesity.

  8. Development of High-Thrust and Double-Sided Linear Synchronous Motor Module For Liquid Crystal Display Equipment

    Institute of Scientific and Technical Information of China (English)

    Myung-jin; CHUNG; Sang-yeon; HWANG

    2010-01-01

    <正>Recently,there is an increasing requirement for controlling linear motion up to a few hundred of millimeter strokes in the area of the liquid crystal display(LCD) production equipment.The requirements of the motion system for LCD production equipment are high acceleration and high velocity with positioning accuracy.To satisfy these requirements,it has to be designed with the high-thrust force and low velocity ripple.In this work, high-thrust and double-sided linear synchronous motor (LSM)module is proposed and the developed high-thrust and double-sided LSM module is verified by performance test.

  9. Development and Psychometric Properties of the Dialysis Module of the WHOQOL-BREF Taiwan Version

    Directory of Open Access Journals (Sweden)

    Shu-Chang Yang

    2006-01-01

    Conclusion: Besides broader coverage than the core WHOQOL-BREF(TW, the dialysis module of the WHOQOL-BREF(TW is a valid, reliable and sensitive QOL instrument for the assessment of HD patients in Taiwan.

  10. Development and testing of shingle-type solar cell modules. Quarterly report No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, N.F.

    1978-01-05

    The details of a shingle module design which produces in excess of 97 watts/m/sup 2/ of module area at 1 kW/m/sup 2/ insolation and at 60/sup 0/C are reported. This selected design employs a tempered glass coverplate to provide the primary solar cell structural support. The use of the B.F. Goodrich FLEXSEAL roofing system as the outer skin of the shingle substrate provides a high confidence of achieving the 15 year service life goal. The fabrication and testing of a preproduction module of this design has demonstrated that this selected approach will meet the environmental testing requirements imposed by the contract. Attempts to fabricate a preproduction module of an alternative design, which embeds the solar cell assembly within a methyl methacrylate casting, proved unsuccessful.

  11. Technological sciences society of the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-04-15

    This book introduces information-oriented society of the twenty-first century connected to computer network for example memory of dream : F-ram, information-oriented society : New media, communications network for next generation ; ISDN on what is IDSN?, development of information service industry, from office automation to an intelligent building in the future, home shopping and home banking and rock that hinders information-oriented society.

  12. Development of an interactive module to enhance and understand cavity navigation.

    Science.gov (United States)

    Navarro Newball, Andrés A; Roviello, Franco; Prattichizzo, Domenico; Herrera, Francisco J; Marin, Cesar A

    2007-01-01

    The Interactive Module for Cavity Navigation (IMCA) was created in order to enhance the Web Environment for Surgical Skills Training in Otolaryngology (WESST--OT); later, it was found that it could be used as an independent module which allowed the practice of path navigation in any medical cavity, and its potential use with patients was evidenced. This paper describes the making of IMCA and the potential use of genetic algorithms in path generation.

  13. Development of 3 kW at 325 MHz solid-state RF power amplifier using four power amplifier modules

    Science.gov (United States)

    Ramarao, B. V.; Sonal, S.; Mishra, J. K.; Pande, M.; Singh, P.; Kumar, G.; Mukherjee, J.

    2014-01-01

    A high power solid-state RF power amplifier of 3 kW at 325 MHz has been developed using only four RF power amplifier modules of 850 W power output each. The design and characterization of RF power modules have been presented. A four way Wilkinson power combiner adds the output of four power amplifier modules with a total transmission loss of less than 6%. The combined power amplifier has a power gain of 20.2 dB at 1-dB compression point, and the corresponding output power is 2.8 kW at 325 MHz. The drain efficiency of the power amplifier is 65.3% at 3 kW. All the harmonics of this amplifier are below -40 dBc. The amplifier has better characteristics like fewer numbers of active devices per kilo watt, high efficiency, high gain, and ruggedness etc for RF accelerator applications.

  14. Development of additional module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation

    Energy Technology Data Exchange (ETDEWEB)

    Proskuryakov, K.N.; Bogomazov, D.N.; Poliakov, N. [Moscow Power Engineering Institute (Technical University), Moscow (Russian Federation)

    2007-07-01

    The new special module to neutron-physic and thermal-hydraulic computer codes for coolant acoustical characteristics calculation is worked out. The Russian computer code Rainbow has been selected for joint use with a developed module. This code system provides the possibility of EFOCP (Eigen Frequencies of Oscillations of the Coolant Pressure) calculations in any coolant acoustical elements of primary circuits of NPP. EFOCP values have been calculated for transient and for stationary operating. The calculated results for nominal operating were compared with results of measured EFOCP. For example, this comparison was provided for the system: 'pressurizer + surge line' of a WWER-1000 reactor. The calculated result 0.58 Hz practically coincides with the result of measurement (0.6 Hz). The EFOCP variations in transients are also shown. The presented results are intended to be useful for NPP vibration-acoustical certification. There are no serious difficulties for using this module with other computer codes.

  15. Method for Backplane Data Communication with the VME Rear Transition Modules Developed for the ATLAS FTK Project

    CERN Document Server

    Bogdan, M; The ATLAS collaboration; Piendibene, M; Shochet, M; Tompkins, L

    2013-01-01

    This paper presents a method to achieve backplane data transfer capabilities to and from a VME Rear Transition Module (RTM), while being in full compliance with the VME64/VIPA Specification. The VMEbus is specified for data transfers only with boards plugged on the front side of the subrack. The RTMs receive power from the crate, but are not part of the actual data transfer bus. They do not plug into the J1 connector, and have no access to backplane interface logic. In this implementation, the RTM uses the feed-through pins located in the J2 connector to communicate with the corresponding front module. The front module's internal data, address, and control buses are extended to the rear. This allows the front module's interface block to control data transfers for logic devices on both sides of the same slot. All usual VME protocols to logic devices on the RTM become possible without any software adaptation. This method was implemented on several prototype modules developed for the ATLAS FTK Project. The full ...

  16. From Classrooms to Geosciences Careers: Developing and Testing a Curriculum Module and Web Application for Modeling Water in Urban Environments

    Science.gov (United States)

    Cervenec, J. M.; Durand, M. T.

    2014-12-01

    A curriculum module created to teach basic principles of hydrology and promote geoscience careers at the high school level will be shared. The module, consisting of five exercises of increasing complexity, focuses on investigating local problems in hydrology using tangible models, readily available online tools, and a custom-built web application. The module culminates in students examining changing land use patterns over time and looking at subsequent impacts on runoff. Materials were field tested during two summer workshops for educators and support was provided during the subsequent school years. Participants reported that the materials filled existing voids in their instructional materials, that they preferred to select individual exercises for use in their classrooms rather than the module as a whole, and that they found online tools in geosciences and connections to local field sites and geoscience professionals to be particularly valuable. Furthermore, while the five exercises where developed for use together in high school classrooms, individual exercises were found to be applicable in classrooms from the elementary through graduate levels. The module addresses NGSS Disciplinary Core Idea - The Role of Water in Earth's Surface Processes in addition to Cross Cutting Concepts - Systems and System Models and Influence of Engineering, Technology, and Science on Society and the Natural World and multiple NGSS Practices.

  17. Development of 3 kW at 325 MHz solid-state RF power amplifier using four power amplifier modules

    Energy Technology Data Exchange (ETDEWEB)

    Ramarao, B.V., E-mail: bvram@barc.gov.in [Ion Accelerator Development Division, Bhabha Atomic Research Center, Mumbai 400085 (India); Sonal, S.; Mishra, J.K.; Pande, M.; Singh, P. [Ion Accelerator Development Division, Bhabha Atomic Research Center, Mumbai 400085 (India); Kumar, G.; Mukherjee, J. [Indian Institute of Technology, Powai, Mumbai 400076 (India)

    2014-01-21

    A high power solid-state RF power amplifier of 3 kW at 325 MHz has been developed using only four RF power amplifier modules of 850 W power output each. The design and characterization of RF power modules have been presented. A four way Wilkinson power combiner adds the output of four power amplifier modules with a total transmission loss of less than 6%. The combined power amplifier has a power gain of 20.2 dB at 1-dB compression point, and the corresponding output power is 2.8 kW at 325 MHz. The drain efficiency of the power amplifier is 65.3% at 3 kW. All the harmonics of this amplifier are below −40 dBc. The amplifier has better characteristics like fewer numbers of active devices per kilo watt, high efficiency, high gain, and ruggedness etc for RF accelerator applications. -- Highlights: • High gain power amplifier, power gain at 20 dB. • High efficiency amplifier, efficiency >65%. • Minimum number of modules per kilo watt power output. • Heat sink with modules on both side, high density.

  18. Responding empathically to patients: Development, implementation, and evaluation of a communication skills training module for oncology nurses.

    Science.gov (United States)

    Pehrson, Cassandra; Banerjee, Smita C; Manna, Ruth; Shen, Megan Johnson; Hammonds, Stacey; Coyle, Nessa; Krueger, Carol A; Maloney, Erin; Zaider, Talia; Bylund, Carma L

    2016-04-01

    The purpose of this paper is to report on the development, implementation, and evaluation of a Communication Skills Training (CST) module for inpatient oncology nurses on how to respond empathically to patients. 248 nurses from a USA cancer center participated in a CST module on responding empathically to patients. Nurses completed pre- and post-training Standardized Patient Assessments (SPAs), a survey on their confidence in and intent to utilize skills taught, and a six-month post-training survey of self-reported use of skills. Results indicate that nurses were satisfied with the module, reporting that agreement or strong agreement to 5 out of 6 items assessing satisfaction 96.7%-98.0% of the time. Nurses' self-efficacy in responding empathically significantly increased pre- to post-training. Additionally, nurses showed empathy skill improvement in the post-SPAs. Finally, 88.2% of nurses reported feeling confident in using the skills they learned post-training and reported an increase of 42-63% in the use of specific empathic skills. A CST module for nurses in responding empathically to patients showed feasibility, acceptability, and improvement in self-efficacy as well as skill uptake. This CST module provides an easily targeted intervention for improving nurse-patient communication and patient-centered care. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  19. Intelligence in the Twenty-First Century

    OpenAIRE

    2000-01-01

    The author concludes that the world will most probably remain rife with conflict even in the twenty first century and that the traditional role of intelligence will not only continue but will increase in importance. He characterizes the international situation as being "more of the same historically"; that is, the existence of several different centers of power and mutual conflicts based solely on national interests. In order to protect and promote one's national interests, sovereign states w...

  20. Developing research competencies through a project-based tissue-engineering module in the biomedical engineering undergraduate curriculum.

    Science.gov (United States)

    Wallen, M; Pandit, A

    2009-05-01

    In addressing the task of developing an undergraduate module in the field of tissue engineering, the greatest challenge lies in managing to capture what is a growing and rapidly changing field. Acknowledging the call for the development of greater critical thinking and interpersonal skills among the next generation of engineers as well as encouraging students to engage actively with the dynamic nature of research in the field, the module was developed to include both project-based and cooperative-learning experiences. These learning activities include developing hypotheses for the application of newly introduced laboratory procedures, a collaborative mock grant submission, and debates on ethical issues in which students are assigned roles as various stakeholders. Feedback from module evaluations has indicated that, while students find the expectations challenging, they are able to gain an advanced insight into a dynamic field. More importantly, students develop research competencies by engaging in activities that require them to link current research directions with their own development of hypotheses for future tissue-engineering applications.

  1. Modulation of post‐movement beta rebound by contraction force and rate of force development

    Science.gov (United States)

    Fry, Adam; Mullinger, Karen J.; O'Neill, George C.; Barratt, Eleanor L.; Morris, Peter G.; Bauer, Markus; Folland, Jonathan P.

    2016-01-01

    Abstract Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory phenomena in the brain. In the preparation and execution phases of movement, a loss in beta amplitude is observed [movement related beta decrease (MRBD)]. This is followed by a rebound above baseline on movement cessation [post movement beta rebound (PMBR)]. These effects have been measured widely, and recent work suggests that they may have significant importance. Specifically, they have potential to form the basis of biomarkers for disease, and have been used in neuroscience applications ranging from brain computer interfaces to markers of neural plasticity. However, despite the robust nature of both MRBD and PMBR, the phenomena themselves are poorly understood. In this study, we characterise MRBD and PMBR during a carefully controlled isometric wrist flexion paradigm, isolating two fundamental movement parameters; force output, and the rate of force development (RFD). Our results show that neither altered force output nor RFD has a significant effect on MRBD. In contrast, PMBR was altered by both parameters. Higher force output results in greater PMBR amplitude, and greater RFD results in a PMBR which is higher in amplitude and shorter in duration. These findings demonstrate that careful control of movement parameters can systematically change PMBR. Further, for temporally protracted movements, the PMBR can be over 7 s in duration. This means accurate control of movement and judicious selection of paradigm parameters are critical in future clinical and basic neuroscientific studies of sensorimotor beta oscillations. Hum Brain Mapp 37:2493–2511, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc PMID:27061243

  2. Evolutionary functions of early social modulation of hypothalamic-pituitary-adrenal axis development in humans.

    Science.gov (United States)

    Flinn, Mark V; Nepomnaschy, Pablo A; Muehlenbein, Michael P; Ponzi, Davide

    2011-06-01

    The hypothalamic-pituitary-adrenal axis (HPAA) is highly responsive to social challenges. Because stress hormones can have negative developmental and health consequences, this presents an evolutionary paradox: Why would natural selection have favored mechanisms that elevate stress hormone levels in response to psychosocial stimuli? Here we review the hypothesis that large brains, an extended childhood and intensive family care in humans are adaptations resulting from selective forces exerted by the increasingly complex and dynamic social and cultural environment that co-evolved with these traits. Variations in the modulation of stress responses mediated by specific HPAA characteristics (e.g., baseline cortisol levels, and changes in cortisol levels in response to challenges) are viewed as phenotypically plastic, ontogenetic responses to specific environmental signals. From this perspective, we discuss relations between physiological stress responses and life history trajectories, particularly the development of social competencies. We present brief summaries of data on hormones, indicators of morbidity and social environments from our long-term, naturalistic studies in both Guatemala and Dominica. Results indicate that difficult family environments and traumatic social events are associated with temporal elevations of cortisol, suppressed reproductive functioning and elevated morbidity. The long-term effects of traumatic early experiences on cortisol profiles are complex and indicate domain-specific effects, with normal recovery from physical stressors, but some heightened response to negative-affect social challenges. We consider these results to be consistent with the hypothesis that developmental programming of the HPAA and other neuroendocrine systems associated with stress responses may facilitate cognitive targeting of salient social challenges in specific environments. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. Modulation of post-movement beta rebound by contraction force and rate of force development.

    Science.gov (United States)

    Fry, Adam; Mullinger, Karen J; O'Neill, George C; Barratt, Eleanor L; Morris, Peter G; Bauer, Markus; Folland, Jonathan P; Brookes, Matthew J

    2016-07-01

    Movement induced modulation of the beta rhythm is one of the most robust neural oscillatory phenomena in the brain. In the preparation and execution phases of movement, a loss in beta amplitude is observed [movement related beta decrease (MRBD)]. This is followed by a rebound above baseline on movement cessation [post movement beta rebound (PMBR)]. These effects have been measured widely, and recent work suggests that they may have significant importance. Specifically, they have potential to form the basis of biomarkers for disease, and have been used in neuroscience applications ranging from brain computer interfaces to markers of neural plasticity. However, despite the robust nature of both MRBD and PMBR, the phenomena themselves are poorly understood. In this study, we characterise MRBD and PMBR during a carefully controlled isometric wrist flexion paradigm, isolating two fundamental movement parameters; force output, and the rate of force development (RFD). Our results show that neither altered force output nor RFD has a significant effect on MRBD. In contrast, PMBR was altered by both parameters. Higher force output results in greater PMBR amplitude, and greater RFD results in a PMBR which is higher in amplitude and shorter in duration. These findings demonstrate that careful control of movement parameters can systematically change PMBR. Further, for temporally protracted movements, the PMBR can be over 7 s in duration. This means accurate control of movement and judicious selection of paradigm parameters are critical in future clinical and basic neuroscientific studies of sensorimotor beta oscillations. Hum Brain Mapp 37:2493-2511, 2016. © 2016 Wiley Periodicals, Inc.

  4. Ynamide Click chemistry in development of triazole VEGFR2 TK modulators.

    Science.gov (United States)

    Vojtičková, Margaréta; Dobiaš, Juraj; Hanquet, Gilles; Addová, Gabriela; Cetin-Atalay, Rengul; Yildirim, Deniz Cansen; Boháč, Andrej

    2015-10-20

    Structure novelty, chemical stability and synthetic feasibility attracted us to design 1,2,3-triazole compounds as potential inhibitors of VEGFR2 tyrosine kinase. Novel triazoles T1-T7 were proposed by oxazole (AAZ from PDB: 1Y6A)/1,2,3-triazole isosteric replacement, molecular modelling and docking. In order to enable synthesis of T1-T7 we developed a methodology for preparation of ynamide 22. Compound 22 was used for all Click chemistry reactions leading to triazoles T1-T3 and T6-T7. Among the obtained products, T1, T3 and T7 specifically bind VEGFR2 TK and modulate its activity by concentration dependent manner. Moreover predicted binding poses of T1-T7 in VEGFR2 TK were similar to the one known for the oxazole inhibitor AAZ (PDB: 1Y6A). Unfortunately the VEGFR2 inhibition by triazoles e.g. T3 and T7 is lower than that determined for their oxazole bioisosters T3-ox and AAZ, resp. Different electronic properties of 1,2,3-triazole/oxazole heterocyclic rings were proposed to be the main reason for the diminished affinity of T1-T3, T6 and T7 to an oxazole AAZ inhibitor binding site in VEGFR2 TK (PDB: 1Y6A or 1Y6B). Moreover T1-T3 and T6 were screened on cytotoxic activity against two human hepatocellular carcinoma cell lines. Selective cytotoxic activity of T2 against aggressive Mahlavu cells has been discovered indicating possible affinity of T2 to Mahlavu constitutionally active PI3K/Akt pathway.

  5. Strain-specific colonization patterns and serum modulation of multi-species oral biofilm development.

    Science.gov (United States)

    Biyikoğlu, Basak; Ricker, Austin; Diaz, Patricia I

    2012-08-01

    Periodontitis results from an ecological shift in the composition of subgingival biofilms. Subgingival community maturation is modulated by inter-organismal interactions and the relationship of communities with the host. In an effort to better understand this process, we evaluated biofilm formation, with oral commensal species, by three strains of the subgingivally prevalent microorganism Fusobacterium nucleatum and four strains of the periodontopathogen Porphyromonas gingivalis. We also tested the effect of serum, which resembles gingival exudates, on subgingival biofilms. Biofilms were allowed to develop in flow cells using salivary medium. We found that although not all strains of F. nucleatum were able to grow in mono-species biofilms, forming a community with health-associated partners Actinomyces oris and Veillonella parvula promoted biofilm growth of all F. nucleatum strains. Strains of P. gingivalis also showed variable ability to form mono-species biofilms. P. gingivalis W50 and W83 did not form biofilms, while ATCC 33277 and 381 formed biofilm structures, but only strain ATCC 33277 grew over time. Unlike the enhanced growth of F. nucleatum with the two health-associated species, no strain of P. gingivalis grew in three-species communities with A. oris and V. parvula. However, addition of F. nucleatum facilitated growth of P. gingivalis ATCC 33277 with health-associated partners. Importantly, serum negatively affected the adhesion of F. nucleatum, while it favored biofilm growth by P. gingivalis. This work highlights strain specificity in subgingival biofilm formation. Environmental factors such as serum alter the colonization patterns of oral microorganisms and could impact subgingival biofilms by selectively promoting pathogenic species.

  6. Auxin and ethylene response interactions during Arabidopsis root hair development dissected by auxin influx modulators.

    Science.gov (United States)

    Rahman, Abidur; Hosokawa, Satoko; Oono, Yutaka; Amakawa, Taisaku; Goto, Nobuharu; Tsurumi, Seiji

    2002-12-01

    The plant hormones auxin and ethylene have been shown to play important roles during root hair development. However, cross talk between auxin and ethylene makes it difficult to understand the independent role of either hormone. To dissect their respective roles, we examined the effects of two compounds, chromosaponin I (CSI) and 1-naphthoxyacetic acid (1-NOA), on the root hair developmental process in wild-type Arabidopsis, ethylene-insensitive mutant ein2-1, and auxin influx mutants aux1-7, aux1-22, and double mutant aux1-7 ein2. Beta-glucuronidase (GUS) expression analysis in the BA-GUS transgenic line, consisting of auxin-responsive domains of PS-IAA4/5 promoter and GUS reporter, revealed that 1-NOA and CSI act as auxin uptake inhibitors in Arabidopsis roots. The frequency of root hairs in ein2-1 roots was greatly reduced in the presence of CSI or 1-NOA, suggesting that endogenous auxin plays a critical role for the root hair initiation in the absence of an ethylene response. All of these mutants showed a reduction in root hair length, however, the root hair length could be restored with a variable concentration of 1-naphthaleneacetic acid (NAA). NAA (10 nM) restored the root hair length of aux1 mutants to wild-type level, whereas 100 nM NAA was needed for ein2-1 and aux1-7 ein2 mutants. Our results suggest that insensitivity in ethylene response affects the auxin-driven root hair elongation. CSI exhibited a similar effect to 1-NOA, reducing root hair growth and the number of root hair-bearing cells in wild-type and ein2-1 roots, while stimulating these traits in aux1-7and aux1-7ein2 roots, confirming that CSI is a unique modulator of AUX1.

  7. Development of a Respiratory Inductive Plethysmography Module Supporting Multiple Sensors for Wearable Systems

    Directory of Open Access Journals (Sweden)

    Zhengbo Zhang

    2012-09-01

    Full Text Available In this paper, we present an RIP module with the features of supporting multiple inductive sensors, no variable frequency LC oscillator, low power consumption, and automatic gain adjustment for each channel. Based on the method of inductance measurement without using a variable frequency LC oscillator, we further integrate pulse amplitude modulation and time division multiplexing scheme into a module to support multiple RIP sensors. All inductive sensors are excited by a high-frequency electric current periodically and momentarily, and the inductance of each sensor is measured during the time when the electric current is fed to it. To improve the amplitude response of the RIP sensors, we optimize the sensing unit with a matching capacitor parallel with each RIP sensor forming a frequency selection filter. Performance tests on the linearity of the output with cross-sectional area and the accuracy of respiratory volume estimation demonstrate good linearity and accurate lung volume estimation. Power consumption of this new RIP module with two sensors is very low. The performance of respiration measurement during movement is also evaluated. This RIP module is especially desirable for wearable systems with multiple RIP sensors for long-term respiration monitoring.

  8. Development of a respiratory inductive plethysmography module supporting multiple sensors for wearable systems.

    Science.gov (United States)

    Zhang, Zhengbo; Zheng, Jiewen; Wu, Hao; Wang, Weidong; Wang, Buqing; Liu, Hongyun

    2012-09-27

    In this paper, we present an RIP module with the features of supporting multiple inductive sensors, no variable frequency LC oscillator, low power consumption, and automatic gain adjustment for each channel. Based on the method of inductance measurement without using a variable frequency LC oscillator, we further integrate pulse amplitude modulation and time division multiplexing scheme into a module to support multiple RIP sensors. All inductive sensors are excited by a high-frequency electric current periodically and momentarily, and the inductance of each sensor is measured during the time when the electric current is fed to it. To improve the amplitude response of the RIP sensors, we optimize the sensing unit with a matching capacitor parallel with each RIP sensor forming a frequency selection filter. Performance tests on the linearity of the output with cross-sectional area and the accuracy of respiratory volume estimation demonstrate good linearity and accurate lung volume estimation. Power consumption of this new RIP module with two sensors is very low. The performance of respiration measurement during movement is also evaluated. This RIP module is especially desirable for wearable systems with multiple RIP sensors for long-term respiration monitoring.

  9. High Temperature Superconductivity in the Past Twenty Years Part 1-Discovery, Material, and Theory

    Institute of Scientific and Technical Information of China (English)

    Jian-Xun Jin

    2008-01-01

    Twenty years after the discovery of high- temperature superconductors (HTSs), the HTS mate- rials now have been well developed. Meanwhile the mechanism of superconductivity is still one of the topical interests in physics. The achievements made on HTS materials and theories during the last twenty years are reviewed comprehensively in this paper.

  10. Slowmation: A Twenty-First Century Educational Tool for Science and Mathematics Pre-Service Teachers

    Science.gov (United States)

    Paige, Kathryn; Bentley, Brendan; Dobson, Stephen

    2016-01-01

    Slowmation is a twenty-first century digital literacy educational tool. This teaching and learning tool has been incorporated as an assessment strategy in the curriculum area of science and mathematics with pre-service teachers (PSTs). This paper explores two themes: developing twenty-first century digital literacy skills and modelling best…

  11. Development of a Thermoelectric Module Suitable for Vehicles and Based on CoSb3 Manufactured Close to Production

    Science.gov (United States)

    Klein Altstedde, Mirko; Sottong, Reinhard; Freitag, Oliver; Kober, Martin; Dreißigacker, Volker; Zabrocki, Knud; Szabo, Patric

    2015-06-01

    Despite the ongoing electrification of vehicle propulsion systems, vehicles with combustion engines will continue to bear the brunt of passenger services worldwide for the next few decades. As a result, the German Aerospace Center Institute of Vehicle Concepts, the Institute of Materials Research and the Institute of Technical Thermodynamics have focused on utilising the exhaust heat of internal combustion engines by means of thermoelectric generators (TEGs). Their primary goal is the development of cost-efficient TEGs with long-term stability and maximised energy yield. In addition to the overall TEG system design, the development of long-term stable, efficient thermoelectric modules (TEMs) for high-temperature applications is a great challenge. This paper presents the results of internal development work and reveals an expedient module design for use in TEGs suitable for vehicles. The TEM requirements identified, which were obtained by means of experiments on the test vehicle and test bench, are described first. Doped semiconductor materials were produced and characterised by production methods capable of being scaled up in order to represent series application. The results in terms of thermoelectric properties (Seebeck coefficient, electrical conductivity and thermal conductivity) were used for the simulative design of a thermoelectric module using a constant-property model and with the aid of FEM calculations. Thermomechanical calculations of material stability were carried out in addition to the TEM's thermodynamic and thermoelectric design. The film sequence within the module represented a special challenge. Multilayer films facilitated adaptation of the thermal and mechanical properties of plasma-sprayed films. A joint which dispenses with solder additives was also possible using multilayer films. The research resulted in a functionally-optimised module design, which was enhanced for use in motor vehicles using process flexibility and close

  12. Developing antifouling biointerfaces based on bioinspired zwitterionic dopamine through pH-modulated assembly.

    Science.gov (United States)

    Huang, Chun-Jen; Wang, Lin-Chuan; Shyue, Jing-Jong; Chang, Ying-Chih

    2014-10-28

    The use of synthetic biomaterials as implantable devices typically is accompanied by considerable nonspecific adsorption of proteins, cells, and bacteria. These may eventually induce adverse pathogenic problems in clinical practice, such as thrombosis and biomaterial-associated infection. Thus, an effective surface coating for medical devices has been pursued to repel nonspecific adsorption from surfaces. In this study, we employ an adhesive dopamine molecule conjugated with zwitterionic sulfobetaine moiety (SB-DA), developed based on natural mussels, as a surface ligand for the modification of TiO2. The electrochemical study shows that the SB-DA exhibits fully reversible reduction-oxidation behavior at pH 3, but it is irreversible at pH 8. A contact angle goniometer and X-ray photoelectron spectroscopy were utilized to explore the surface hydration, chemical states, and bonding mechanism of SB-DA. The results indicate that the binding between hydroxyl groups of SB-DA and TiO2 converts from hydrogen bonds to bidentate binding upon the pH transition from pH 3 to 8. In order to examine the antifouling properties of SB-DA thin films, the modified substrates were brought into contact with bovine serum albumin and bacteria solutions. The fouling levels were monitored using a quartz crystal microbalance with dissipation sensor and fluorescence optical microscope. Tests showed that the sample prepared via the pH transition approach provides the best resistance to nonspecific adsorption due to the high coverage and stability of the SB-DA films. These findings support the mechanism of the pH-modulated assembly of SB-DA molecules, and for the first time we demonstrate the antifouling properties of the SB-DA to be comparable with traditional thiol-based zwitterionic self-assemblies. The success of modification with SB-DA opens an avenue for developing a biologically inspired surface chemistry and can have applications over a wide spectrum of bioapplications. The strategy of

  13. Development of teaching modules for geology and engineering coursework using terrestrial LiDAR scanning systems

    Science.gov (United States)

    Yarbrough, L. D.; Katzenstein, K.

    2012-12-01

    of designed engineering solutions. These course learning modules were developed for traditional geological engineering courses delivered on campus, for more intensive field work courses and online-based asynchronous course delivery.

  14. Development of Low-Cost Remote-Control Generators Based on BiTe Thermoelectric Modules

    Science.gov (United States)

    Juanicó, Luis E.; Rinalde, Fabián; Taglialavore, Eduardo; Molina, Marcelo

    2013-07-01

    This paper presents a new thermogenerator based on moderate-temperature (up to 175°C) BiTe modules available on the open market. Despite this handicap relative to commercial thermogenerators based on high-temperature proprietary-technology PbBi modules (up to 560°C), this new design may become economically competitive due to its innovative thermal sink. Our thermal sink is based on a free-convection water loop built with standard tubing and household hot-water radiators, leading to a more practical, modular design. So, the specific cost of about 55,000 USD/kW obtained for this 120-W prototype is improved to 33,000 USD/kW for a 1-kW unit, which represents about half the price of commercial thermogenerators. Moreover, considering recently launched BiTe modules (that withstand up to 320°C), our proposition could have an even more favorable outlook.

  15. A module on death and dying to develop empathy in student pharmacists.

    Science.gov (United States)

    Manolakis, Michael L; Olin, Jacqueline L; Thornton, Phillip L; Dolder, Christian R; Hanrahan, Conor

    2011-05-10

    To implement an integrated module on death and dying into a 15-week bioethics course and determine whether it increased student pharmacists' empathy. Students participated in a 5-week death and dying module that included presentation of the film Wit, an interactive lecture on hospice, and a lecture on the ethics of pain management. Fifty-six students completed the 30-item Balanced Emotional Empathy Scale (BEES) before and after completing the module and wrote a reflective essay. Students demonstrated an appreciation of patient-specific values in their essay. Quantitative data collected via BEES scores demonstrated significant improvement in measured empathy. A 5-week instructional model on death and dying significantly increased student empathy.

  16. Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

    Directory of Open Access Journals (Sweden)

    Zheng-Quan Tang

    Full Text Available Neurons in the nucleus laminaris (NL of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a dual modulation by presynaptic GABA(B receptors (GABA(BRs and metabotropic glutamate receptors (mGluRs. Here, using in vitro whole-cell patch clamp recordings from acute brain slices of the chick, we characterized the following important but unknown properties pertaining to such a dual modulation: (1 emergence of functional GABA synapses in NL neurons; (2 the temporal onset of neuromodulation mediated by GABA(BRs and mGluRs; and (3 the physiological conditions under which GABA(BRs and mGluRs are activated by endogenous transmitters. We found that (1 GABA(AR-mediated synaptic responses were observed in about half of the neurons at embryonic day 11 (E11; (2 GABA(BR-mediated modulation of the GABAergic transmission was detectable at E11, whereas the modulation by mGluRs did not emerge until E15; and (3 endogenous activity of GABA(BRs was induced by both low- (5 or 10 Hz and high-frequency (200 Hz stimulation of the GABAergic pathway, whereas endogenous activity of mGluRs was induced by high- (200 Hz but not low-frequency (5 or 10 Hz stimulation of the glutamatergic pathway. Furthermore, the endogenous activity of mGluRs was mediated by group II but not group III members. Therefore, autoreceptor-mediated modulation of GABAergic transmission emerges at the same time when the GABA synapses become functional. Heteroreceptor-mediated modulation appears at a later time and is receptor type dependent in vitro.

  17. Development of Instrumentation for Spin-Echo Induced Spatial Beam Modulations

    DEFF Research Database (Denmark)

    Sales, Morten

    Spin-Echo Modulated Small Angle Neutron Scattering in Time-of-Flight mode (ToF SEMSANS) is an emerging technique extending the measurable phase space covered by neutron scattering. Using inclined magnetic field surfaces, (very) small angle scattering from a sample can be mapped into the spin...... Institute Delft, TUDelft, and resolve the modulation using absorption gratings in front of a detector without spatial resolution, i.e. a simple counting detector. Combining this with a virtual copy of the instrument, built using the Monte Carlo Ray-Tracing simulation package McStas, we were able to expand...

  18. Development of horn antenna mixer array with internal local oscillator module for microwave imaging diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kuwahara, D., E-mail: dkuwahar@cc.tuat.ac.jp [Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588 (Japan); Ito, N. [Department of Intelligent System Engineering, Ube National College of Technology, Ube, Yamaguchi 755-8555 (Japan); Nagayama, Y. [Department of Helical Plasma Research, National Institute for Fusion Science, Toki, Gifu 509-5292 (Japan); Yoshinaga, T. [Department of Applied Physics, National Defense Academy, Yokosuka, Kanagawa 239-0811 (Japan); Yamaguchi, S. [Department of Pure and Applied Physics, Kansai University, Suita, Osaka 564-8680 (Japan); Yoshikawa, M.; Kohagura, J. [Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Ibaraki 305-8577 (Japan); Sugito, S. [Equipment Development Center, Institute for Molecular Science, Okazaki, Aichi 444-8585 (Japan); Kogi, Y. [Department of Information Electronics, Fukuoka Institute of Technology, Fukuoka, Fukuoka 811-0295 (Japan); Mase, A. [Art, Science and Technology Center for Cooperative Research, Kyusyu University, Kasuga, Fukuoka 816-8580 (Japan)

    2014-11-15

    A new antenna array is proposed in order to improve the sensitivity and complexity of microwave imaging diagnostics systems such as a microwave imaging reflectometry, a microwave imaging interferometer, and an electron cyclotron emission imaging. The antenna array consists of five elements: a horn antenna, a waveguide-to-microstrip line transition, a mixer, a local oscillation (LO) module, and an intermediate frequency amplifier. By using an LO module, the LO optics can be removed, and the supplied LO power to each element can be equalized. We report details of the antenna array and characteristics of a prototype antenna array.

  19. Development of horn antenna mixer array with internal local oscillator module for microwave imaging diagnostics.

    Science.gov (United States)

    Kuwahara, D; Ito, N; Nagayama, Y; Yoshinaga, T; Yamaguchi, S; Yoshikawa, M; Kohagura, J; Sugito, S; Kogi, Y; Mase, A

    2014-11-01

    A new antenna array is proposed in order to improve the sensitivity and complexity of microwave imaging diagnostics systems such as a microwave imaging reflectometry, a microwave imaging interferometer, and an electron cyclotron emission imaging. The antenna array consists of five elements: a horn antenna, a waveguide-to-microstrip line transition, a mixer, a local oscillation (LO) module, and an intermediate frequency amplifier. By using an LO module, the LO optics can be removed, and the supplied LO power to each element can be equalized. We report details of the antenna array and characteristics of a prototype antenna array.

  20. Development of advanced multi-tone mask by using two different transmittance modulation materials

    Science.gov (United States)

    Kim, Sei-Min; Choi, Min-Ki; Seo, Seong-Min; Lee, Jong-Hwa; Shin, Cheol; Jeong, Woo-Gun; Jung, Sung-Mo; Nam, Kee-Soo

    2016-09-01

    Multi-tone mask (MTM) consists of more than two layers having different transmittance modulation layers. A novel method is proposed to manufacture a MTM based on two kinds of transmittance modulation materials such as chromium and molybdenum. Different modulation materials cannot be only act as etch-stopper to each other, but also they play a role as a separator between the layers consisted of MTM. Furthermore, clearly classified modulation layers contribute to define one of the targeted transmittance according to different etching process. Especially, a conventional MTM requires three mask writing processes to form three patterns whereas the proposed MTM structure makes it possible to form three patterns by using only two mask writing processes. It is found that the turnaround time of proposed MTM is remarkably decreased as value of 30% compared to that of conventional MTM. MoSi-/Cr-based tri-tone mask configuration having 37, 15, and 0% of transmittance had been demonstrated based on the optimized thin-film conditions. Optical uniformity characteristics were also carried out to evaluate the photomask performance. Consequently, the proposed MTM is not only expected to extend the variation of objective transmittance, but also it is a very promise method for achieving a high performance photo-mask by reducing its fabrication cost.

  1. Price Development of Photovoltaic Modules, Inverters and Systems in the Netherlands

    NARCIS (Netherlands)

    Sark, W.G.J.H.M. van; Muizebelt, P.; Cace, J.; Vries, A. de; Rijk, P. de

    2014-01-01

    Since 2010 the Dutch photovoltaic (PV) market has been growing fast, with around doubling of installed capacity in 2011 and 2012. Four quarterly inventories have been made in 2012 for modules, inverters, and systems that are presently available for purchase in the Netherlands. We have found that the

  2. Price development of photovoltaic modules, inverters, and systems in the Netherlands in 2012

    NARCIS (Netherlands)

    Van Sark, Wilfried G J H M|info:eu-repo/dai/nl/074628526; Muizebelt, Peter; Cace, Jadranka; de Vries, Arthur; de Rijk, Peer

    2014-01-01

    Since 2010 the Dutch photovoltaic (PV) market has been growing fast, with around doubling of installed capacity in 2011 and 2012. Four quarterly inventories have been made in 2012 for modules, inverters, and systems that are presently available for purchase in the Netherlands. We have found that the

  3. Human Development XI: The Structure of the Cerebral Cortex. Are There Really Modules in the Brain?

    Directory of Open Access Journals (Sweden)

    Tyge Dahl Hermansen

    2007-01-01

    Full Text Available The structure of human consciousness is thought to be closely connected to the structure of cerebral cortex. One of the most appreciated concepts in this regard is the Szanthagothei model of a modular building of neo-cortex. The modules are believed to organize brain activity pretty much like a computer. We looked at examples in the literature and argue that there is no significant evidence that supports Szanthagothei's model. We discuss the use of the limited genetic information, the corticocortical afferents termination and the columns in primary sensory cortex as arguments for the existence of the cortex-module. Further, we discuss the results of experiments with Luminization Microscopy (LM colouration of myalinized fibres, in which vertical bundles of afferent/efferent fibres that could support the cortex module are identified. We conclude that sensory maps seem not to be an expression for simple specific connectivity, but rather to be functional defined. We also conclude that evidence for the existence of the postulated module or column does not exist in the discussed material. This opens up for an important discussion of the brain as functionally directed by biological information (information-directed self-organisation, and for consciousness being closely linked to the structure of the universe at large. Consciousness is thus not a local phenomena limited to the brain, but a much more global phenomena connected to the wholeness of the world.

  4. Development of Instrumentation for Spin-Echo Induced Spatial Beam Modulations

    DEFF Research Database (Denmark)

    Sales, Morten

    Institute Delft, TUDelft, and resolve the modulation using absorption gratings in front of a detector without spatial resolution, i.e. a simple counting detector. Combining this with a virtual copy of the instrument, built using the Monte Carlo Ray-Tracing simulation package McStas, we were able to expand...

  5. Design and Development of Hybrid Multilevel Inverter employing Dual Reference Modulation Technique for Fuel Cell Applications

    Directory of Open Access Journals (Sweden)

    R. Seyezhai

    2011-10-01

    Full Text Available MultiLevel Inverter (MLI has been recognized as an attractive topology for high voltage DC-AC conversion. This paper focuses on a new dual reference modulation technique for a hybrid multilevel inverter employing Silicon carbide (SiC switches for fuel cell applications. The proposed modulation technique employs two reference waveforms and a single inverted sine wave as the carrier waveform. This technique is compared with the conventional dual carrier waveform in terms of output voltage spectral quality and switching losses. An experimental five-level hybrid inverter test rig has been built using SiC switches to implement the proposed algorithm. Gating signals are generated using PIC microcontroller. The performance of the inverter has been analyzed and compared with the result obtained from theory and simulation. Simulation study of Proportional Integral (PI controller for the inverter employing the proposed modulation strategy has been done in MATLAB/SIMULINK. Keywords: Multilevel inverter, SiC , dual reference modulation, switching losses, PI

  6. [Development of an add-on module for the WHOQOL-BREF on patients with allergic rhinitis].

    Science.gov (United States)

    Wang, Chiu-Hua; Maa, Suh-Hwa; Yang, Sien-Hung; Chen, Ying-Lin; Chen, Wei-Chun

    2008-06-01

    The purpose of this study was to develop an add-on module for the Taiwan-version WHOQOL-BREF for assessing the quality of life of people with allergic rhinitis. A cross-sectional survey design was used. In accordance with the seven steps for the development of population-specific modules of the WHOQOL, the instrument added new items on the basis of opinions of expert groups, including patients, families and physicians, to the Taiwan-version WHOQOL-BREF measure. The new questionnaire, comprising 52 items, was tested on 252 patients with allergic rhinitis. For content validity, each item was significantly correlated with the domain to which it belonged (r= .157-.715, pWHOQOL-BREF for patients with allergic rhinitis is reliable, valid and specific.

  7. Development of a Pilot Learning Module on Water Energy Nexus Using a Data-Analytic and Hypothesis-Driven Approach

    Science.gov (United States)

    Eldardiry, H. A.; Unruh, H. G., Sr.; Habib, E. H.; Tidwell, V. C.

    2016-12-01

    Recent community initiatives have identified key foundational knowledge gaps that need to be addressed before transformative solutions can be made in the area of Food, Energy and Water (FEW) nexus. In addition, knowledge gaps also exist in the area of FEW education and needs to be addressed before we can make an impact on building the next generation FEW workforces. This study reports on the development of a pilot learning-module that focuses on two elements of the FEW nexus, Energy and Water. The module follows an active-learning approach to develop a set of student-centered learning activities using FEW datasets situated in real-world settings in the contiguous US. The module is based on data-driven learning exercises that incorporate different geospatial layers and manipulate datasets at a watershed scale representing the eight-digit Hydrologic Unit Code (HUC8). Examples of such datasets include water usage by different demand sectors (available from the US Geological Survey, USGS), and power plants stratified by energy source, cooling technology, and plant capacity (available from the US Energy Information Administration, EIA). The module is structured in three sections: (1) introduction to the water and energy systems, (2) quantifying stresses on water system at a catchment scale, and (3) scenario-based analysis on the interdependencies in the water-energy systems. Following a data-analytic framework, the module guides students to make different assumptions about water use growth rates and see how these new water demands will impinge on freshwater supplies. The module engages students in analysis that examines how thermoelectric water use would depend on assumptions about future demand for electricity, power plant fuel source, cooling type, and carbon sequestration. Students vary the input parameters, observe and assess the effect on water use, and address gaps via non-potable water resources (e.g., municipal wastewater). The module is implemented using a web

  8. Development of a high-power solid-state switch using static induction thyristors for a klystron modulator

    Energy Technology Data Exchange (ETDEWEB)

    Tokuchi, Akira, E-mail: tokuchi@sanken.osaka-u.ac.jp [Institute of Scientific and Industrial Research, Osaka University, Suita (Japan); Pulsed Power Japan Laboratory Ltd., Kusatsu (Japan); Extreme Energy-Density Research Institute, Nagaoka University of Technology, Nagaoka (Japan); Kamitsukasa, Fumiyoshi, E-mail: kamitsukasa@ess.sci.osaka-u.ac.jp [Institute of Scientific and Industrial Research, Osaka University, Suita (Japan); Furukawa, Kazuya; Kawase, Keigo; Kato, Ryukou; Irizawa, Akinori; Fujimoto, Masaki; Osumi, Hiroki; Funakoshi, Sousuke; Tsutsumi, Ryouta; Suemine, Shoji; Honda, Yoshihide; Isoyama, Goro [Institute of Scientific and Industrial Research, Osaka University, Suita (Japan)

    2015-01-01

    We developed a solid-state switch with static induction thyristors for the klystron modulator of the L-band electron linear accelerator (linac) at the Institute of Scientific and Industrial Research, Osaka University. This switch is designed to have maximum specifications of a holding voltage of 25 kV and a current of 6 kA at the repetition frequency of 10 Hz for forced air cooling. The turn-on time of the switch was measured with a matched resistor to be 270 ns, which is sufficiently fast for the klystron modulator. The switch is retrofitted in the modulator to generate 1.3 GHz RF pulses with durations of either 4 or 8 μs using a 30 MW klystron, and the linac is successfully operated under maximum conditions. This finding demonstrates that the switch can be used as a high-power switch for the modulator. Pulse-to-pulse variations of the klystron voltage are measured to be less than 0.015%, and those of RF power and phase are lower than 0.15% and 0.1°, respectively. These values are significantly smaller than those obtained with a thyratron; hence, the stability of the main RF system is improved. The solid-state switch has been used in normal operation of the linac for more than a year without any serious trouble. Thus, we confirmed the switch’s robustness and long-term reliability.

  9. Flexible CdTe Solar Cells and Modules: Cooperative Research and Development Final Report, CRADA Number CRD-14-548

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Teresa [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-05-01

    Lucintech and NREL will collaborate to develop flexible CdTe solar cells on flexible glass using sputtering and other deposition technologies. This initial work will be conducted under the DOE funded Foundational Program to Advance Cell Efficiency (FPACE) 1 project, and the interaction with Lucintech will focus on scaling up and transferring the high efficiency cell processes to module production on a pilot line.

  10. It participates in 'international workshop on the concrete technology for sustainable development in the twenty-first century'; '21 seiki ni okeru jizokuteki hatten no tameno konkurito gijutsu ni kansuru kokusai waku shoppu' ni sankashite

    Energy Technology Data Exchange (ETDEWEB)

    Noguchi, Takafumi; Ishida, Tetsuya [The University of Tokyo, Tokyo (Japan)

    1998-10-10

    International workshop on the concrete technology for sustainable development in the twenty-first century' was held in Norway. From the viewpoint of the durability by corrosion of steel, present state and problem and future direction to be aimed of design the Grorv professor mainly show system of the RC structure. Here, the construction of the estimable frame was emphasized in the life cycle including the maintenance repair. And, the lecture on concept of the performance evaluation die design system and concrete content of the integrated design was made from the Sakai professor as future flow of the design code of reinforced concrete structure in our country and world. (NEDO)

  11. Requirements for a Dynamic Solvent Extraction Module to Support Development of Advanced Technologies for the Recycle of Used Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Jack Law; Veronica Rutledge; Candido Pereira; Jackie Copple; Kurt Frey; John Krebs; Laura Maggos; Kevin Nichols; Kent Wardle; Pratap Sadasivan; Valmor DeAlmieda; David Depaoli

    2011-06-01

    The Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program has been established to create and deploy next generation, verified and validated nuclear energy modeling and simulation capabilities for the design, implementation, and operation of future nuclear energy systems to improve the U.S. energy security. As part of the NEAMS program, Integrated Performance and Safety Codes (IPSC's) are being produced to significantly advance the status of modeling and simulation of energy systems beyond what is currently available to the extent that the new codes be readily functional in the short term and extensible in the longer term. The four IPSC areas include Safeguards and Separations, Reactors, Fuels, and Waste Forms. As part of the Safeguards and Separations (SafeSeps) IPSC effort, interoperable process models are being developed that enable dynamic simulation of an advanced separations plant. A SafeSepss IPSC 'toolkit' is in development to enable the integration of separation process modules and safeguards tools into the design process by providing an environment to compose, verify and validate a simulation application to be used for analysis of various plant configurations and operating conditions. The modules of this toolkit will be implemented on a modern, expandable architecture with the flexibility to explore and evaluate a wide range of process options while preserving their stand-alone usability. Modules implemented at the plant-level will initially incorporate relatively simple representations for each process through a reduced modeling approach. Final versions will incorporate the capability to bridge to subscale models to provide required fidelity in chemical and physical processes. A dynamic solvent extraction model and its module implementation are needed to support the development of this integrated plant model. As a stand-alone application, it will also support solvent development of extraction flowsheets

  12. Development of a Web-Based L-THIA 2012 Direct Runoff and Pollutant Auto-Calibration Module Using a Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Chunhwa Jang

    2013-11-01

    Full Text Available The Long-Term Hydrology Impact Assessment (L-THIA model has been used as a screening evaluation tool in assessing not only urbanization, but also land-use changes on hydrology in many countries. However, L-THIA has limitations due to the number of available land-use data that can represent a watershed and the land surface complexity causing uncertainties in manually calibrating various input parameters of L-THIA. Thus, we modified the L-THIA model so that could use various (twenty three land-use categories by considering various hydrologic responses and nonpoint source (NPS pollutant loads. Then, we developed a web-based auto-calibration module by integrating a Genetic-Algorithm (GA into the L-THIA 2012 that can automatically calibrate Curve Numbers (CNs for direct runoff estimations. Based on the optimized CNs and Even Mean Concentrations (EMCs, our approach calibrated surface runoff and nonpoint source (NPS pollution loads by minimizing the differences between the observed and simulated data. Here, we used default EMCs of biochemical oxygen demand (BOD, total nitrogen (TN, and total phosphorus-TP (as the default values to L-THIA collected at various local regions in South Korea corresponding to the classifications of different rainfall intensities and land use for improving predicted NPS pollutions. For assessing the model performance, the Yeoju-Gun and Icheon-Si sites in South Korea were selected. The calibrated runoff and NPS (BOD, TN, and TP pollutions matched the observations with the correlation (R2: 0.908 for runoff and R2: 0.882–0.981 for NPS and Nash-Sutcliffe Efficiency (NSE: 0.794 for runoff and NSE: 0.882–0.981 for NPS for the sites. We also compared the NPS pollution differences between the calibrated and averaged (default EMCs. The calibrated TN and TP (only for Yeoju-Gun EMCs-based pollution loads identified well with the measured data at the study sites, but the BOD loads with the averaged EMCs were slightly better than

  13. Lrp4 modulates extracellular integration of cell signaling pathways in development.

    Directory of Open Access Journals (Sweden)

    Atsushi Ohazama

    Full Text Available The extent to which cell signaling is integrated outside the cell is not currently appreciated. We show that a member of the low-density receptor-related protein family, Lrp4 modulates and integrates Bmp and canonical Wnt signalling during tooth morphogenesis by binding the secreted Bmp antagonist protein Wise. Mouse mutants of Lrp4 and Wise exhibit identical tooth phenotypes that include supernumerary incisors and molars, and fused molars. We propose that the Lrp4/Wise interaction acts as an extracellular integrator of epithelial-mesenchymal cell signaling. Wise, secreted from mesenchyme cells binds to BMP's and also to Lrp4 that is expressed on epithelial cells. This binding then results in the modulation of Wnt activity in the epithelial cells. Thus in this context Wise acts as an extracellular signaling molecule linking two signaling pathways. We further show that a downstream mediator of this integration is the Shh signaling pathway.

  14. Development of laryngeal video stroboscope with laser marking module for dynamic glottis measurement.

    Science.gov (United States)

    Kuo, Chung-Feng Jeffrey; Wang, Hsing-Won; Hsiao, Shang-Wun; Peng, Kai-Ching; Chou, Ying-Liang; Lai, Chun-Yu; Hsu, Chien-Tung Max

    2014-01-01

    Physicians clinically use laryngeal video stroboscope as an auxiliary instrument to test glottal diseases, and read vocal fold images and voice quality for diagnosis. As the position of vocal fold varies in each person, the proportion of the vocal fold size as presented in the vocal fold image is different, making it impossible to directly estimate relevant glottis physiological parameters, such as the length, area, perimeter, and opening angle of the glottis. Hence, this study designs an innovative laser projection marking module for the laryngeal video stroboscope to provide reference parameters for image scaling conversion. This innovative laser projection marking module to be installed on the laryngeal video stroboscope using laser beams to project onto the glottis plane, in order to provide reference parameters for scaling conversion of images of laryngeal video stroboscope.

  15. Education in Flux--Implications for Curriculum Development. Presentations Made at the Twenty-Ninth Annual Meeting of the Professors of Curriculum (Detroit, Michigan, March 2-3, 1979).

    Science.gov (United States)

    Jelinek, James John, Ed.

    This collection of conference presentations includes "The Curriculum Field--A View" by Alice Miel, "The State of the Curriculum: Frills, Fads, and Alternatives" by Robert S. Zais, "Lifelong Learning: Significance for Curriculum Development" by Norman V. Overly, "Education of the Gifted and Talented: A Look Around…

  16. Design, development and construction of an outdoor testing facility for semi-transparent photovoltaic modules

    OpenAIRE

    Olivieri, Lorenzo; Caamaño Martín, Estefanía; Olivieri, Francesca; Neila Gonzalez, Francisco Javier

    2013-01-01

    Building-integrated Photovoltaics (BIPV) is one of the most promising technologies enabling buildings to generate on-site part of their electricity needs while performing architectural functionalities. A clear example of BIPV products consists of semi-transparent photovoltaic modules (STPV), designed to replace the conventional glazing solutions in building façades. Accordingly, the active building envelope is required to perform multiple requirements such as provide solar shading to avoid ...

  17. Development of an Optically Modulated Scatterer Probe for a Near-Field Measurement System

    Science.gov (United States)

    2016-09-08

    proportional to the gain of the AUT after normalizing by the antenna pattern of the known receiver. If the scattering strength of the probe is modulated...optical power until no change was observed. The real and imaginary components of the impedance for the PDA photodiode with no light ( dark ) and at various...GHz there was a change in impedance between the dark (off) and maximum optical power (on) states of 40 Ohm in the real component and 80 Ohm in the

  18. Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

    CERN Document Server

    Garcia-Argos, Carlos; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas in the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

  19. Modules and Front-End Electronics Developments for the ATLAS ITk Strips Upgrade

    CERN Document Server

    Garcia-Argos, Carlos; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment is currently preparing for an upgrade of the tracking system in the course of the High Luminosity LHC, scheduled for 2024. The existing Inner Detector will be replaced by an all-silicon Inner Tracker (ITk) with a pixel detector surrounded by a strip detector. The ITk strip detector consists of a four layer barrel and a forward region composed of six discs on each side of the barrel. The basic unit of the detector is the silicon-strip module, consisting of a sensor and one or more hybrid circuits that hold the read-out electronics. The geometries of the barrel and end-cap modules take into account the regions that they have to cover. In the central region, the detectors are rectangular with straight strips, whereas on the forward region the modules require wedge shaped sensors with varying strip length and pitch. The current prototyping phase has resulted in the ITk Strip Detector Technical Design Report (TDR), which kicks-off the pre-production readiness phase at the involved institutes. ...

  20. Development and characterization of microfiltration hollow-fiber modules for sterilization of fermentation media

    Directory of Open Access Journals (Sweden)

    L.F.F. Faria

    2002-04-01

    Full Text Available Sterilization of fermentation medium involving heat may result in undesirable chemical reactions that alter nutrient concentration and yield products, which interfere in the fermentation performance. Sterilization of heat-sensitive compounds usually involves separate sterilizations of carbon source and nutrient solution. Membrane separation processes are an alternative to thermal processes, as they have many advantages such as the possibility of continuous and modular operation and the use of moderate temperatures. In this context, the objective of this work was the preparation of hollow-fiber membranes and the design of modules suitable for continuous sterilization of fermentation medium. The membrane with the best performance had a maximum pore diameter of 0.2 mu m and a permeability of 42.9 L/m².bar.h for a glucose/peptone/yeast extract medium. A module with 0.26 m² of permeation area was built with these membranes. This module was able to provide a permeate flow rate of 2.2 L/h using a pressure difference of 0.2 bar. The collected permeate was completely sterile, thus confirming the efficiency of this process.

  1. Modulators of inhibitor of growth (ING) family expression in development and disease.

    Science.gov (United States)

    Maher, Stacey K; Helbing, Caren C

    2009-05-01

    The inhibitor of growth (ING) gene family proteins regulate many critical cellular processes such as cell proliferation and growth, apoptosis, DNA repair, senescence, angiogenesis, and drug resistance. Their transcripts and proteins are differentially expressed in health and disease and there is evidence for developmental regulation. The vast majority of studies have characterized ING levels in the context of cancer. However, relatively little attention has been paid to the expression of ING family members in other contexts. This review summarizes the findings from human and animal model systems that provide insight into the factors influencing the expression of these important proteins. We examine the influence of cell cycle and aging as well as genotoxic stress on ING expression levels and evaluate several emerging areas of inquiry demonstrating that ING gene activity may be modulated by factors such as the p53 tumor suppressor, DNA methylation, and ING proteins themselves with external factors such as hormones, reactive oxygen species, TGFbeta signalling, and other proteins of pathological significance also influencing ING levels. We then briefly discuss the influence of post-translational modification and changes in subcellular localization as it pertains to modulation of ING expression. Understanding how ING expression is modulated represents a vital aspect of effective drug targeting strategies.

  2. Development of the MCM-D technique for pixel detector modules

    CERN Document Server

    Grah, Christian

    2005-01-01

    This thesis treats a copper--polymer based thin film technology, the MCM-D technique and its application when building hybrid pixel detector modules. The ATLAS experiment at the LHC will be equipped with a pixel detector system. The basic mechanical units of the pixel detector are multi chip modules. The main components of these modules are: 16 electronic chips, a controller chip and a large sensor tile, featuring more than 46000 sensor cells. MCM-D is a superior technique to build the necessary signal bus system and the power distribution system directly on the active sensor tile. In collaboration with the Fraunhofer Institute for Reliability and Microintegration, IZM, the thin film process is reviewed and enhanced. The multi layer system was designed and optimized for the interconnection system as well as for the 46000 pixel contacts. Laboratory measurements on prototypes prove that complex routing schemes for geometrically optimized single chips are suitable and have negligible influence on the front--end ...

  3. Development of Nanofiller-Modulated Polymeric Oxygen Enrichment Membranes for Reduction of Nitrogen Oxides in Coal Combustion

    Energy Technology Data Exchange (ETDEWEB)

    Jianzhong Lou; Shamsuddin Ilias

    2010-12-31

    North Carolina A&T State University in Greensboro, North Carolina, has undertaken this project to develop the knowledge and the material to improve the oxygen-enrichment polymer membrane, in order to provide high-grade oxygen-enriched streams for coal combustion and gasification applications. Both experimental and theoretical approaches were used in this project. The membranes evaluated thus far include single-walled carbon nano-tube, nano-fumed silica polydimethylsiloxane (PDMS), and zeolite-modulated polyimide membranes. To document the nanofiller-modulated polymer, molecular dynamics simulations have been conducted to calculate the theoretical oxygen molecular diffusion coefficient and nitrogen molecular coefficient inside single-walled carbon nano-tube PDMS membranes, in order to predict the effect of the nano-tubes on the gas-separation permeability. The team has performed permeation and diffusion experiments using polymers with nano-silica particles, nano-tubes, and zeolites as fillers; studied the influence of nano-fillers on the self diffusion, free volume, glass transition, oxygen diffusion and solubility, and perm-selectivity of oxygen in polymer membranes; developed molecular models of single-walled carbon nano-tube and nano-fumed silica PDMS membranes, and zeolites-modulated polyimide membranes. This project partially supported three graduate students (two finished degrees and one transferred to other institution). This project has resulted in two journal publications and additional publications will be prepared in the near future.

  4. Development of Nanofiller-Modulated Polymeric Oxygen Enrichment Membranes for Reduction of Nitrogen Oxides in Coal Combustion

    Energy Technology Data Exchange (ETDEWEB)

    Jianzhong Lou; Shamsuddin Ilias

    2010-12-31

    North Carolina A&T State University in Greensboro, North Carolina, has undertaken this project to develop the knowledge and the material to improve the oxygen-enrichment polymer membrane, in order to provide high-grade oxygen-enriched streams for coal combustion and gasification applications. Both experimental and theoretical approaches were used in this project. The membranes evaluated thus far include single-walled carbon nano-tube, nano-fumed silica polydimethylsiloxane (PDMS), and zeolite-modulated polyimide membranes. To document the nanofiller-modulated polymer, molecular dynamics simulations have been conducted to calculate the theoretical oxygen molecular diffusion coefficient and nitrogen molecular coefficient inside single-walled carbon nano-tube PDMS membranes, in order to predict the effect of the nano-tubes on the gas-separation permeability. The team has performed permeation and diffusion experiments using polymers with nano-silica particles, nano-tubes, and zeolites as fillers; studied the influence of nano-fillers on the self diffusion, free volume, glass transition, oxygen diffusion and solubility, and perm-selectivity of oxygen in polymer membranes; developed molecular models of single-walled carbon nano-tube and nano-fumed silica PDMS membranes, and zeolites-modulated polyimide membranes. This project partially supported three graduate students (two finished degrees and one transferred to other institution). This project has resulted in two journal publications and additional publications will be prepared in the near future.

  5. Operationally efficient propulsion system study (OEPSS) data book. Volume 9; Preliminary Development Plan for an Integrated Booster Propulsion Module (BPM)

    Science.gov (United States)

    DiBlasi, Angelo G.

    1992-01-01

    A preliminary development plan for an integrated propulsion module (IPM) is described. The IPM, similar to the Space Transportation Main engine (STME) engine, is applicable to the Advanced Launch System (ALS) baseline vehicle. The same STME development program ground rules and time schedule were assumed for the IPM. However, the unique advantages of testing an integrated engine element, in terms of reduced number of hardware and number of system and reliability tests, compared to single standalone engine and MPTA, are highlighted. The potential ability of the IPM to meet the ALS program goals for robustness, operability and reliability is emphasized.

  6. The role of superregular breathers in the development of modulation instability

    Science.gov (United States)

    Gelash, Andrey

    2016-04-01

    The integrable model of modulation instability (MI) - the one-dimensional nonlinear Schrodinger equation (NLSE) is in the focus of research for many years. Recently a significant progress has been made in the understanding of MI long time consequences (nonlinear stage of MI). Namely, the role of continuous spectrum was studied in the work [1], another two works are devoted to integrable turbulence formation [2] and to the Fermi-Pasta-Ulam recurrence [3]. We proposed so-called superregular breathers scenario of MI in [4]. In this scenario instability evolves from small localized perturbations of the condensate to N pairs of breathers which moves in opposite directions leaving a nonperturbed condensate with changed phase behind them. Recently we observed superregular breathers in hydrodynamics and optics experiments [5]. Here we discuss the role of superregular breathers in general scenario of MI. Furthermore we study another important question - the formation of freak waves from the perturbed condensate. To date two possible scenarios in the frame of NLSE have been described: 1) the collisions of Akhmediev breathers and 2) the rational solutions, such as Peregrine breather. In the first case the initial conditions usually include breathers of quite large amplitude. In the case of rational scenario the solution is pure homoclinic, i.e. completely returns to initial unperturbed condensate. Meanwhile, results of numerical modeling of freak waves formation in more exact models like Euler equation and NLSE with higher nonlinearities demonstrate formation of breathers. We present a new model of freak waves formation caused by particular collisions of superregular breathers. In the frame of this scenario extreme waves appear from small perturbations of the condensate and leave breathers, which never disappear. We study special two-pair superregular breathers scenario as well as randomly distributed N pairs solution. The latter case can be considered as a kind of integrable

  7. The characterization of twenty sequenced human genomes.

    Directory of Open Access Journals (Sweden)

    Kimberly Pelak

    2010-09-01

    Full Text Available We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes. We summarize the number of genetic variants emerging from a study of this magnitude, and provide a proof of concept for the identification of rare and highly-penetrant functional variants by confirming that the cause of hemophilia A is easily recognizable in this data set. We also show that the number of novel single nucleotide variants (SNVs discovered per genome seems to stabilize at about 144,000 new variants per genome, after the first 15 individuals have been sequenced. Finally, we find that, on average, each genome carries 165 homozygous protein-truncating or stop loss variants in genes representing a diverse set of pathways.

  8. Development of an open source software module for enhanced visualization during MR-guided interstitial gynecologic brachytherapy.

    Science.gov (United States)

    Chen, Xiaojun; Egger, Jan

    2014-01-01

    In 2010, gynecologic malignancies were the 4th leading cause of death in U.S. women and for patients with extensive primary or recurrent disease, treatment with interstitial brachytherapy may be an option. However, brachytherapy requires precise insertion of hollow catheters with introducers into the tumor in order to eradicate the cancer. In this study, a software solution to assist interstitial gynecologic brachytherapy has been investigated and the software has been realized as an own module under (3D) Slicer, which is a free open source software platform for (translational) biomedical research. The developed research module allows on-time processing of intra-operative magnetic resonance imaging (iMRI) data over a direct DICOM connection to a MR scanner. Afterwards follows a multi-stage registration of CAD models of the medical brachytherapy devices (template, obturator) to the patient's MR images, enabling the virtual placement of interstitial needles to assist the physician during the intervention.

  9. DEVELOPMENT OF A CO2 SEQUESTRATION MODULE BY INTEGRATING MINERAL ACTIVATION AND AQUEOUS CARBONATION

    Energy Technology Data Exchange (ETDEWEB)

    M. Mercedes Maroto-Valer; John M. Andresen; George Alexander

    2004-11-15

    Mineral carbonation is a promising concept for permanent CO{sub 2} sequestration due to the vast natural abundance of the raw minerals, the permanent storage of CO{sub 2} in solid form as carbonates, and the overall reaction being exothermic. However, the primary drawback to mineral carbonation is the reaction kinetics. To accelerate the reaction, aqueous carbonation processes are preferred, where the minerals are firstly dissolved in solution. In aqueous carbonation, the key step is the dissolution rate of the mineral, where the mineral dissolution reaction is likely to be surface controlled. In order to accelerate the dissolution process, the serpentine can be ground to very fine particle size (<37 {micro}m), but this is a very energy intensive process. Alternatively, magnesium could be chemically extracted in aqueous solution. Phase I showed that chemical surface activation helps to dissolve the magnesium from the serpentine minerals (particle size {approx}100 {micro}m), and furthermore, the carbonation reaction can be conducted under mild conditions (20 C and 650 psig) compared to previous studies that required >185 C, >1850 psig and <37 {micro}m particle size. Phase I also showed that over 70% of the magnesium can be extracted at ambient temperature leaving amorphous SiO{sub 2} with surface areas {approx} 330m{sup 2}/g. The overall objective of Phase 2 of this research program is to optimize the active carbonation process developed in Phase I in order to design an integrated CO{sub 2} sequestration module. During the current reporting period, Task 1 ''Mineral activation'' was initiated and focused on a parametric study to optimize the operation conditions for the mineral activation, where serpentine and sulfuric acid were reacted, as following the results from Phase 1. Several experimental factors were outlined as having a potential influence on the mineral activation. This study has focused to date on the effects of varying the acid

  10. Accelerators for the twenty-first century a review

    CERN Document Server

    Wilson, Edmund J N

    1990-01-01

    The development of the synchrotron, and later the storage ring, was based upon the electrical technology at the turn of this century, aided by the microwave radar techniques of World War II. This method of acceleration seems to have reached its limit. Even superconductivity is not likely to lead to devices that will satisfy physics needs into the twenty-first century. Unless a new principle for accelerating elementary particles is discovered soon, it is difficult to imagine that high-energy physics will continue to reach out to higher energies and luminosities.

  11. The Review and Reflection of the Development of Shanghai Community College in Recent Twenty Years%上海社区学院发展20年的回顾与思考

    Institute of Scientific and Technical Information of China (English)

    宋亦芳

    2013-01-01

    自1993年上海提出组建社区学院到现在已有20年的历程,伴随着上海社区教育和学习型社会建设的稳步推进,上海社区学院也经历了一段不平凡的发展过程,既面临体制与机制架构之难题,也经历功能定位之困惑,在不断探索与实践中逐步找到自己的位置并得到稳步的发展。在“完善终身教育体系,建设学习型社会”的新形势下,上海社区学院应怎样发展,应如何进一步发挥其作用,需要我们进一步探索和思考。%Since 1993 ,Shanghai proposed to set up community college till now for 20 years .With Shanghai community education and the construction of learning society ,Shanghai’s community college has gone through an extraordinary development process ,facied the problem of system and mechanism framework and experienced the confusion of functional localization .In the continuous exploration and practice gradually found their ow n positions and achieve steady development . In new situation “to perfect lifelong education system and build a learning society” ,it is necessary to further explore and think that the Shanghai community college should be how to develop and how to further play its role .

  12. Development of Automated Production Line Processes for Solar Brightfield Modules: Final Annual Technical Progress Report, 1 July 2004 -- 15 October 2005

    Energy Technology Data Exchange (ETDEWEB)

    Nowlan, M. J.; Murach, J. M.; Sutherland, S. F.; Miller, D. C.; Moore S. B.; Hogan, S. J.

    2006-08-01

    Spire Corporation is addressing the Photovoltaic Manufacturing R&D project goals of improving photovoltaic (PV) manufacturing processes and products while reducing costs and providing a technology foundation that supports significant manufacturing scale-up. To accomplish this, we are focusing our efforts on the design of a large-area utility-scale module and the development of the necessary manufacturing techniques and equipment to manufacture such a module in a high-volume production environment. A three-phase program is under way for developing and demonstrating new automated systems for fabricating very large PV modules ideal for use in multi-megawatt grid-connected applications. We designed a large-area (1.57 m x 3.68 m) 800-W module, and we are developing associated module production equipment that will minimize the total installed system cost for utility-scale PV arrays. Activities in Phase 2 focused on the development of automation for module materials lay-up, cell string busing, and module lamination; enhancements to the cell stringing and lamination processes; and performance testing of large-area modules.

  13. Development of New Low-Cost, High-Performance, PV Module Encapsulant/Packaging Materials: Final Technical Progress Report, 22 October 2002 - 15 November 2007

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, R.

    2008-04-01

    Report on objectives to work with U.S.-based PV module manufacturers (c-Si, a-Si, CIS, other thin films) to develop/qualify new low-cost, high-performance PV module encapsulant/packaging materials, and processes using the packaging materials.

  14. Development of Gas Turbine Fast Mathematical Model Simulation Module for Software Complex «Electrodin» based on LabVIEW

    Directory of Open Access Journals (Sweden)

    Olga A. Iarmonova

    2013-01-01

    Full Text Available A fast mathematical model simulation module based on LabVIEW graphical programming environment has been developed. The module will be used for gas turbine and electrical power system co-simulation, and for testing automation of gas turbine automatic control systems.

  15. Twenty-fourth Semiannual Report of the Commission to the Congress, July 1958

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.; McCone, John A.

    1958-07-31

    The document represents the twenty-fourth semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period January - June 1958.

  16. Twenty-second Semiannual Report of the Commission to the Congress, July 1957

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Lewis L.

    1957-07-31

    The document represents the twenty-second semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program covering the period January - June 1957.

  17. An online module series to prepare pharmacists to facilitate student engagement in patient-centered care delivery: development and evaluation

    Directory of Open Access Journals (Sweden)

    Kassam R

    2012-06-01

    Full Text Available Rosemin Kassam,1 Mona Kwong,1 John B Collins21Faculty of Pharmaceutical Sciences, 2Department of Educational Studies, University of British Columbia, Vancouver, CanadaIntroduction: Accreditation bodies across North America have adopted revised standards that place increased emphasis on experiential education and preceptors to promote and demonstrate patient-centered, pharmaceutical care practices to students. Since such practices are still evolving, challenges exist in recruiting skilled preceptors who are prepared to provide such opportunities. An online educational module series titled "A Guide to Pharmaceutical Care" (The Guide was developed and evaluated to facilitate this transition. The objectives of this paper are: (1 to describe the development of the modules; and (2 to present the evaluation results from its pilot testing.Methods: The Guide was developed as an online, self-directed training program. It begins by providing an overview of patient care (PC philosophy and practice, and then discusses the tools that facilitate PC. It also provides a range of tips to support students as they provide PC during their experiential learning. Pharmacists participating in the pilot study were recruited using purposive and snowball sampling techniques. A pre–post quantitative survey with additional open-ended questions was used to evaluate the modules.Results: The modules incorporated a variety of teaching strategies: self-reflection exercises, quizzes to review important concepts, quick tips, flash cards, and video clips to illustrate more in-depth learning. Thirty-two pharmacists completed the pre–post assessment and reported significant increases in their confidence because of this training. The most influenced outcome was "Application of techniques to facilitate learning opportunities that enable pharmacy students to practice pharmaceutical care competencies." They also indicated that the training clarified necessary changes in their

  18. 5-HT receptors involved in initiation or modulation of motor patterns: opportunities for drug development.

    Science.gov (United States)

    Wallis, D I

    1994-08-01

    A clearer understanding of the role of descending systems in motor control can be achieved by using in vitro preparations of mammalian spinal cord that display patterned motor output, together with the use of selective pharmacological agents. It has been suggested that 5-HT is involved in either the initiation or the modulation of certain motor behaviours, and that it acts to enhance or regulate the motor pattern. Most attention has been paid to the locomotor rhythms underlying walking or swimming, and in respiratory pattern generation. In this article, David Wallis discusses the involvement of 5-HT1 and 5-HT2 receptors in these processes and the possible therapeutic relevance.

  19. Design and development of a data acquisition system for photovoltaic modules characterization

    Energy Technology Data Exchange (ETDEWEB)

    Belmili, Hocine [Unite de Developpement des Equipements Solaires (UDES), Route Nationale No11, Bou-Isamil BP 365, Tipaza 42415, Algerie; Ait Cheikh, Salah Med; Haddadi, Mourad; Larbes, Cherif [Ecole Nationale Polytechnique, Laboratoire de Dispositifs de Communication et de Conversion Photovoltaique (LDCCP), 10 Avenue Hassen Badi, El Harrach 16200 Alger (Algeria)

    2010-07-15

    Testing photovoltaic generators performance is complicated. This is due to the influence of a variety of interactive parameters related to the environment such as solar irradiation and temperature in addition to solar cell material (mono-crystalline, poly-crystalline, amorphous and thin films). This paper presents a computer-based instrumentation system for the characterization of the photovoltaic (PV) conversion. It based on a design of a data acquisition system (DAQS) allowing the acquisition and the drawing of the characterization measure of PV modules in real meteorological test conditions. (author)

  20. Development of high data readout rate pixel module and detector hybridization at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Sergio Zimmermann et al.

    2001-03-20

    This paper describes the baseline design and a variation of the pixel module to handle the data rate required for the BTeV experiment at Fermilab. The present prototype has shown good electrical performance characteristics. Indium bump bonding is proven to be capable of successful fabrication at 50 micron pitch on real detectors. For solder bumps at 50 micron pitch, much better results have been obtained with the fluxless PADS processed detectors. The results are adequate for our needs and our tests have validated it as a viable technology.

  1. WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development.

    Directory of Open Access Journals (Sweden)

    Norimasa Iwanami

    2008-08-01

    Full Text Available The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened ethylnitrosourea-induced medaka mutants for recessive defects in thymus development. Here we report that one of those mutants is caused by a missense mutation in a gene encoding the previously uncharacterized protein WDR55 carrying the tryptophan-aspartate-repeat motif. We find that WDR55 is a novel nucleolar protein involved in the production of ribosomal RNA (rRNA. Defects in WDR55 cause aberrant accumulation of rRNA intermediates and cell cycle arrest. A mutation in WDR55 in zebrafish also leads to analogous defects in thymus development, whereas WDR55-null mice are lethal before implantation. These results indicate that WDR55 is a nuclear modulator of rRNA synthesis, cell cycle progression, and embryonic organogenesis including teleost thymus development.

  2. Development of an optimization concept for arc-modulated cone beam therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Silke; Nill, Simeon; Oelfke, Uwe [Department of Medical Physics in Radiation Therapy, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany)

    2007-07-21

    In this paper, we propose an optimization concept for a rotation therapy technique which is referred to as arc-modulated cone beam therapy (AMCBT). The aim is a reduction of the treatment time while achieving a treatment plan quality equal to or better than that of IMRT. Therefore, the complete dose is delivered in one single gantry rotation and the beam is modulated by a multileaf collimator. The degrees of freedom are the field shapes and weights for a predefined number of beam directions. In the new optimization loop, the beam weights are determined by a gradient algorithm and the field shapes by a tabu search algorithm. We present treatment plans for AMCBT for two clinical cases. In comparison to step-and-shoot IMRT treatment plans, it was possible by AMCBT to achieve dose distributions with a better dose conformity to the target and a lower mean dose for the most relevant organ at risk. Furthermore, the number of applied monitor units was reduced for AMCBT in comparison to IMRT treatment plans.

  3. Developing an educational training module in forensic odontology: A proposal for dental curriculum

    Directory of Open Access Journals (Sweden)

    Shally Khanna

    2014-09-01

    Full Text Available A number of methods have been introduced in scientific literature to study the lip print and palatal rugae; still there is a need for more descriptive and self-explanatory methods. Awareness regarding practical knowledge of cheiloscopy and palatoscopy is ambiguous among dental professionals. In the present work, an effort was made to introduce an educational training module for dental professionals with a view to improving the data recording and interpretation methods. A computer aided statistical method has also been suggested, i.e., systematic stage-wise filtering to test the uniqueness of lip and palatal rugae patterns. In this study, dental professionals were asked to match random lip and palatal rugae patterns before and after training. Proportions of accurate matching pre- and post-training were then compared. A systematic stage-wise filtering method was used to prove the uniqueness of lip prints and palatal rugae in large samples. It was observed that the educational training module helped to improve the ability of dental professionals in identifying individuals based on lip prints and palatal rugae. Application of systematic stage-wise filtering technique eased the process of checking the uniqueness of patterns.

  4. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling.

    Science.gov (United States)

    Alpár, Alán; Tortoriello, Giuseppe; Calvigioni, Daniela; Niphakis, Micah J; Milenkovic, Ivan; Bakker, Joanne; Cameron, Gary A; Hanics, János; Morris, Claudia V; Fuzik, János; Kovacs, Gabor G; Cravatt, Benjamin F; Parnavelas, John G; Andrews, William D; Hurd, Yasmin L; Keimpema, Erik; Harkany, Tibor

    2014-07-17

    Local environmental cues are indispensable for axonal growth and guidance during brain circuit formation. Here, we combine genetic and pharmacological tools, as well as systems neuroanatomy in human fetuses and mouse models, to study the role of endocannabinoid and Slit/Robo signalling in axonal growth. We show that excess 2-arachidonoylglycerol, an endocannabinoid affecting directional axonal growth, triggers corpus callosum enlargement due to the errant CB1 cannabinoid receptor-containing corticofugal axon spreading. This phenotype mechanistically relies on the premature differentiation and end-feet proliferation of CB2R-expressing oligodendrocytes. We further show the dependence of both axonal Robo1 positioning and oligodendroglial Slit2 production on cell-type-specific cannabinoid receptor activation. Accordingly, Robo1 and/or Slit2 manipulation limits endocannabinoid modulation of axon guidance. We conclude that endocannabinoids can configure focal Slit2/Robo1 signalling to modulate directional axonal growth, which may provide a basis for understanding impaired brain wiring associated with metabolic deficits and prenatal drug exposure.

  5. The twenty-first century in space

    CERN Document Server

    Evans, Ben

    2015-01-01

    This final entry in the History of Human Space Exploration mini-series by Ben Evans continues with an in-depth look at the latter part of the 20th century and the start of the new millennium. Picking up where Partnership in Space left off, the story commemorating the evolution of manned space exploration unfolds in further detail. More than fifty years after Yuri Gagarin’s pioneering journey into space, Evans extends his overview of how that momentous voyage continued through the decades which followed. The Twenty-first Century in Space, the sixth book in the series, explores how the fledgling partnership between the United States and Russia in the 1990s gradually bore fruit and laid the groundwork for today’s International Space Station. The narrative follows the convergence of the Shuttle and Mir programs, together with standalone missions, including servicing the Hubble Space Telescope, many of whose technical and human lessons enabled the first efforts to build the ISS in orbit. The book also looks to...

  6. Twenty Years After: Armenian Research Libraries Today

    Directory of Open Access Journals (Sweden)

    D. Aram Donabedian

    2012-05-01

    Full Text Available Since achieving statehood in 1991, Armenia has faced major economic and political obstacles which have significantly affected the nation’s research libraries. This research paper will quantitatively and qualitatively examine the challenges facing Armenian research libraries just over twenty years after the collapse of the Soviet Union. Specifically, the authors analyze their interviews with five library administrators at five major institutions, respectively. These include Yerevan State University Library, the National Library of Armenia, the Fundamental Scientific Library of the National Academy of Sciences of Armenia, the Republican Scientific-Medical Library of Armenia, and the Papazian Library of the American University of Armenia. The instrument for the interviews consists of 73 questions based on the 2004 Association of College and Research Libraries Standards for Libraries in Higher Education and evaluates the following factors:• The library’s mission, goals and objectives• Public or user services• Instruction activities at the library• Resources (print, media, or electronic and collection development• Access to the library’s resources• Outcome assessment, or evaluation of the library• Staffing issues• Facility maintenance and plans for library development• Communication and cooperation both within the library and with the user community• Administration• BudgetIn addition, we will focus on the strengths and weaknesses of these libraries and investigate the growing open access movement in Armenia. Based on our findings, the authors wish to facilitate dialogue and consider possible approaches to help these libraries meet Armenia’s pressing information needs.

  7. Development of Web GIS-Based VFSMOD System with Three Modules for Effective Vegetative Filter Strip Design

    Directory of Open Access Journals (Sweden)

    Dong Soo Kong

    2013-08-01

    Full Text Available In recent years, Non-Point Source Pollution has been rising as a significant environmental issue. The sediment-laden water problem is causing serious impacts on river ecosystems not only in South Korea but also in most countries. The vegetative filter strip (VFS has been thought to be one of the most effective methods to reduce the transport of sediment to down-gradient area. However, the effective width of the VFS first needs to be determined before VFS installation in the field. To provide an easy-to-use interface with a scientific VFS modeling engine, the Web GIS-based VFSMOD system was developed in this study. The Web GIS-based VFSMOD uses the UH and VFSM executable programs from the VFSMOD-w model as core engines to simulate rainfall-runoff and sediment trapping. To provide soil information for a point of interest, the Google Map interface to the MapServer soil database system was developed using the Google Map API, Javascript, Perl/CGI, and Oracle DB programming. Three modules of the Web GIS-based VFSMOD system were developed for various VFS designs under single storm, multiple storm, and long-term period scenarios. These modules in the Web GIS-based VFSMOD system were applied to the study watershed in South Korea and these were proven as efficient tools for the VFS design for various purposes.

  8. Twenty-first workshop on geothermal reservoir engineering: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-01-26

    PREFACE The Twenty-First Workshop on Geothermal Reservoir Engineering was held at the Holiday Inn, Palo Alto on January 22-24, 1996. There were one-hundred fifty-five registered participants. Participants came from twenty foreign countries: Argentina, Austria, Canada, Costa Rica, El Salvador, France, Iceland, Indonesia, Italy, Japan, Mexico, The Netherlands, New Zealand, Nicaragua, the Philippines, Romania, Russia, Switzerland, Turkey and the UK. The performance of many geothermal reservoirs outside the United States was described in several of the papers. Professor Roland N. Horne opened the meeting and welcomed visitors. The key note speaker was Marshall Reed, who gave a brief overview of the Department of Energy's current plan. Sixty-six papers were presented in the technical sessions of the workshop. Technical papers were organized into twenty sessions concerning: reservoir assessment, modeling, geology/geochemistry, fracture modeling hot dry rock, geoscience, low enthalpy, injection, well testing, drilling, adsorption and stimulation. Session chairmen were major contributors to the workshop, and we thank: Ben Barker, Bobbie Bishop-Gollan, Tom Box, Jim Combs, John Counsil, Sabodh Garg, Malcolm Grant, Marcel0 Lippmann, Jim Lovekin, John Pritchett, Marshall Reed, Joel Renner, Subir Sanyal, Mike Shook, Alfred Truesdell and Ken Williamson. Jim Lovekin gave the post-dinner speech at the banquet and highlighted the exciting developments in the geothermal field which are taking place worldwide. The Workshop was organized by the Stanford Geothermal Program faculty, staff, and graduate students. We wish to thank our students who operated the audiovisual equipment. Shaun D. Fitzgerald Program Manager.

  9. A pilot study: the development of a culturally tailored Malaysian Diabetes Education Module (MY-DEMO) based on the Health Belief Model

    National Research Council Canada - National Science Library

    Ahmad, Badariah; Ramadas, Amutha; Kia Fatt, Quek; Md Zain, Anuar Zaini

    2014-01-01

    .... Contrastingly, few structured and validated diabetes modules are available in Malaysia. This pilot study aims to develop and validate diabetes education material suitable and tailored for a multicultural society like Malaysia...

  10. Development of a PSpice Modeling Platform for SiC Power MOSFET Modules

    DEFF Research Database (Denmark)

    Ceccarelli, Lorenzo; Iannuzzo, Francesco; Nawaz, Muhammad

    2017-01-01

    The aim of this work is to present a PSpice implementation for a well-established and compact physics-based SiC MOSFET model, including a fast, experimental-based parameter extraction procedure in a MATLAB GUI environment. The model, originally meant for single-die devices, has been used to simul......The aim of this work is to present a PSpice implementation for a well-established and compact physics-based SiC MOSFET model, including a fast, experimental-based parameter extraction procedure in a MATLAB GUI environment. The model, originally meant for single-die devices, has been used...... to simulate the performance of high current rating (above 100 A), multi-chip SiC MOSFET modules, both for static and switching behavior. Therefore, the simulation results have been validated experimentally in a wide range of operating conditions, including high temperatures, gate resistance and stray elements...

  11. Development of a standardized control module for dc-to-dc converters

    Science.gov (United States)

    Yu, Y.; Iwens, R. I.; Lee, F. C.; Inouye, L. Y.

    1977-01-01

    The electrical performance of a power processor depends on the quality of its control system. Most of the existing control circuits suffer one or more of the following imperfections that tend to restrict their respective utility: (1) inability to perform different modes of duty cycle control; (2) lack of immunity to output filter parameter changes, and (3) lack of capability to provide power component stress limiting on an instantaneous basis. The three lagging aspects of existing control circuits have been used to define the major objectives of the current Standardized Control Module (SCM) Program. Detailed information on the SCM functional block diagram, its universality, and performance features, circuit description, test results, and modeling and analysis efforts are presented.

  12. Oxide-based High Temperature Thermoelectric Generators - Development of Integrated Design Technique and Construction of a Thermoelectric Module

    DEFF Research Database (Denmark)

    Wijesooriyage, Waruna Dissanayaka

    In the field of energy management, thermoelectrics are niche candidates for electrical generator devices. For decades, scientists have been focused on thermoelectric (TE) material development. Thus TE module design techniques are still in relatively virgin state when comparing to the TE material...... development. This thesis is focused on development and optimization of thermoelectric generator (TEG) design techniques for high temperature (> 700 °C) applications. Some of the main targets of this optimization process are to achieve higher volumetric power density (VPD), and reduce the cost-per-Watt. Oxide...... of the thermoelectrically mismatched materials. U-TEG removed the weaker TE material and replaced it with a conductor. It is shown that U-TEG is a valuable concept to increase the VPD of a TE device that has mismatched TE materials. Moreover, U-TEG design is generalized using an idealized metal. Furthermore, well...

  13. Design and development of cell queuing, processing, and scheduling modules for the iPOINT input-buffered ATM testbed

    Science.gov (United States)

    Duan, Haoran

    1997-12-01

    heuristic strategy that leads to 'socially optimal' solutions, yielding a maximum number of contention-free cells being scheduled. A novel mixed digital-analog circuit has been designed to implement the MUCS core functionality. The MUCS circuit maps the cell scheduling computation to the capacitor charging and discharging procedures that are conducted fully in parallel. The design has a uniform circuit structure, low interconnect counts, and low chip I/O counts. Using 2 μm CMOS technology, the design operates on a 100 MHz clock and finds a near-optimal solution within a linear processing time. The circuit has been verified at the transistor level by HSPICE simulation. During this research, a five-port IQ-based optoelectronic iPOINT ATM switch has been developed and demonstrated. It has been fully functional with an aggregate throughput of 800 Mb/s. The second-generation IQ-based switch is currently under development. Equipped with iiQueue modules and MUCS module, the new switch system will deliver a multi-gigabit aggregate throughput, eliminate HOL blocking, provide per-VC QoS, and achieve near-100% link bandwidth utilization. Complete documentation of input modules and trunk module for the existing testbed, and complete documentation of 3DQ, iiQueue, and MUCS for the second-generation testbed are given in this dissertation.

  14. Development of measurement device for evaluation of solar cell module output. 2; Taiyo denchi module shutsuryoku hyokayo sokuteiki no kaihatsu. 2

    Energy Technology Data Exchange (ETDEWEB)

    Minoda, M.; Itsumi, J. [Kumamoto Institute of Technology, Kumamoto (Japan)

    1996-10-27

    Enhancement in design efficiency may be attained as well as utilization in maintenance if on-the-spot data is made available, for the purpose of flexibly dealing with changes in design or matching with a house structure, in calculating the power generation output of a solar cell (PV) module. Under the circumstances, a small-sized compound measuring device was produced as a prototype which, using an I-V curve tracer, measured output and condition of a roof at the time of installation, compared with the optimum operation and predicted the power generation. The device was structured with the main body consisting of a computing part, measurement controller and power supply and with various sensor modules. The electron load control method was employed in order to measure I-V characteristics of the PV module, since it was desirable to use a variable load and to cover the range from the release voltage of a solar cell to the short-circuit state through the maximum output point. The reference module method was used for the system evaluation. The device was presumably applicable to a PV system design by incorporating a sensor module for measuring design environment data, which was essential at the time of a system design, in addition to those for measuring output. 9 refs., 4 figs., 3 tabs.

  15. The SouthSouthNorth Capacity Building Module on Poverty Reduction. Approaches for achieving sustainable development and poverty reduction

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-10-15

    While sustainable development in climate change was the core approach in SSN 1, SSN 2 takes a further and direct focus on poverty reduction, as a core theme. Presented by the SSN Capacity Building Team, this Module on Poverty Reduction reflects our current approach to dealing with poverty reduction. Each SSN 2 programme is discussed separately. The SSN Matrix Tool of Indicators for Appraising the Sustainable Development of Projects, from SSN 1, is applied in SSN 2 for assessing poverty reduction by placing special emphasis on a couple of social sustainability indicators. This approach of the Mitigation Programme is followed in the Adaptation Programme. The Adaptation Programme also applies the SSN Adaptation Projects Protocol for Community Based Adaptation. This SSNAPP for CBA is a way to find the hotspots where high levels of poverty and predicted increases in climate impacts coincide. The Technology Receptivity Programme examines approaches for receiving technology in poor communities, examining not only technology hardware but also the software (processes) and orgware (institutions) required. The Capacity Building Programme uses a SWOT tool for analysing a project's strengths, weaknesses, opportunities and threats as a way to determine and ensure the sustainability of projects in terms of technology, finances and social factors. The Module gives the various tools applied by the programmes, with examples from SSN projects. It is presented by the Capacity Building Programme in this format as a movement towards an alignment of approaches within SSN and is shared for use by others who are interested in the pursuit of sustainable projects. As a work in progress this Module will be updated as work goes on.

  16. Twenty Years' Development of the Postdoc Program at CAS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Until recently, the concept of a postdoctoral scholar (postdoc) was new in China although it first appeared about 125 years ago, when Johns Hopkins University adopted an ap prenticeship model of high-level training.

  17. Paternal Benzo[a]pyrene Exposure Modulates MicroRNA Expression Patterns in the Developing Mouse Embryo

    Directory of Open Access Journals (Sweden)

    Asgeir Brevik

    2012-01-01

    Full Text Available Little attention has been given to how microRNA expression is affected by environmental contaminants exposure. We investigate the effects of paternal exposure to benzo[a]pyrene (B[a]P on miRNA expression in the developing mouse embryo. Male mice were exposed to B[a]P (150 mg/kg i.p., and their sperm was used four days later in in-vitro fertilization experiments. Twenty embryos each from 2-, 8-cell and the blastocyst stage were used for genome-wide miRNA expression profiling. Paternal exposure to B[a]P affected the expression of several miRNAs, and the target genes for some of the dysregulated miRNAs were enriched in many different pathways that are likely to be relevant for the developing mouse embryo. By linking the miRNA target genes to publicly available databases, we identified some miRNA target genes that may serve as global markers of B[a]P-mediated genotoxic stress. The dysregulated miRNAs may provide valuable knowledge about potential transgenerational effects of sublethal exposure to chemicals.

  18. Shield fabrication development of ITER primary wall modules by powder HIP. ITER task T216-Subtask 3E1

    Energy Technology Data Exchange (ETDEWEB)

    Lind, A

    1997-12-01

    A research and development program for the blanket shield in the International Thermonuclear Experimental Reactor (ITER) has been implemented to provide input for the design and manufacture of full scale production components. It comprises fabrication and testing of mock-ups and prototype modules. The design, materials, manufacture, examination, testing and inspection of the mock-ups representing future full scale production modules. This work applies to the development of a shield block fabrication method by Hot Isostatic Pressing (HIP) starting from a gas atomised powder and pre-fabricated cooling tube galleries. The size of the block is 1250 x 650 x 250 mm and the weight is about 1400 kg. Examination and testing of the block was performed to determine properties, achieved fabrication tolerances, and quality of bonding. It is concluded that the today`s powder HIP route gives a 316 LN IG material with mechanical properties which fulfills the ITER material specification requirements and a fully dense block which is easy to examine with ultrasonic methods. The joints between tubes and matrix are excellent. In order to achieve and maintain accuracy in positioning of the tubes during fabrication improvements of the standard fabrication route have been identified, such as the positioning of tubes during welding, the powder particle distribution and the powder filling procedure. Modification of the actual HIP cycle may also be required

  19. Critical amino acids in syndecan-4 cytoplasmic domain modulation of turkey satellite cell growth and development.

    Science.gov (United States)

    Song, Yan; McFarland, Douglas C; Velleman, Sandra G

    2012-02-01

    Syndecan-4 is composed of a core protein and covalently attached glycosaminoglycan (GAG) and N-linked glycosylated (N-glycosylated) chains. The core protein is divided into extracellular, transmembrane, and cytoplasmic domains. The cytoplasmic domain has two conserved regions and a variable region in the middle. The Ser residue in the conserved region 1 and the Tyr residue in the variable region are important in regulating protein kinase C alpha (PKCα) membrane localization and focal adhesion formation. The objective of the current study was to investigate the role of syndecan-4 Ser and Tyr residues in combination with the GAG and N-glycosylated chains in turkey satellite cell proliferation, differentiation, fibroblast growth factor 2 (FGF2) responsiveness, and PKCα membrane localization. Site-directed mutagenesis was used to generate Ser and Tyr mutants with or without GAG and N-glycosylated chains. The wild type and mutant syndecan-4 constructs were transfected into turkey satellite cells. The over-expression of Ser and Tyr mutants increased cell proliferation and differentiation and decreased membrane localization of PKCα. Furthermore, Ser mutants enhanced cellular responsiveness to FGF2. The results from this study are the first demonstration of a role of syndecan-4 cytoplasmic domain Ser and Tyr residues in regulating satellite cell proliferation, differentiation, and the modulation of cellular responsiveness to FGF2.

  20. Development of n-in-p pixel modules for the ATLAS Upgrade at HL-LHC

    CERN Document Server

    Macchiolo, Anna; Savic, Natascha; Terzo, Stefano

    2016-01-01

    Thin planar pixel modules are promising candidates to instrument the inner layers of the new ATLAS pixel detector for HL-LHC, thanks to the reduced contribution to the material budget and their high charge collection efficiency after irradiation. 100-200 $\\mu$m thick sensors, interconnected to FE-I4 read-out chips, have been characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements are reported for devices before and after irradiation up to a fluence of $14\\times10^{15}$ n$_{eq}$/cm$^2$. The charge collection and tracking efficiency of the different sensor thicknesses are compared. The outlook for future planar pixel sensor production is discussed, with a focus on sensor design with the pixel pitches (50x50 and 25x100 $\\mu$m$^2$) foreseen for the RD53 Collaboration read-out chip in 65 nm CMOS technology. An optimization of the biasing structures in the pixel cells is required to avoid the hit efficiency loss presently observed in the punch-through region...

  1. Towards the development of chromone-based MEK1/2 modulators.

    Science.gov (United States)

    Redwan, Itedale Namro; Dyrager, Christine; Solano, Carlos; Fernández de Trocóniz, Guillermo; Voisin, Laure; Bliman, David; Meloche, Sylvain; Grøtli, Morten

    2014-10-06

    Inhibition or allosteric modulation of mitogen-activated protein kinase kinases MEK1 and MEK2 (MEK1/2) represent a promising strategy for the discovery of new specific anticancer agents. In this paper, structure-based design, beginning from the lead compound PD98059, was used to study potential structural modifications on the chromone structure in order to obtain highly potent derivatives that target the allosteric pocket in MEK1. Subsequently, a small series of PD98059 analogs were synthesized to provide a first generation of chromone-based derivatives that inhibit the activation of MEK1 with IC50 values as low as 30 nM in vitro. Complementary cellular studies also showed that two of the compounds in the series inhibit the activity of MEK1/2 with IC50 values in the nanomolar range (73-97 nM). In addition, compounds in this series were found to inhibit the proliferation of a small panel of human cancer cell lines. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  2. Development of GaAs Gunn Diodes and Their Applications to Frequency Modulated Continuous Wave Radar

    Science.gov (United States)

    Choi, Seok-Gyu; Han, Min; Baek, Yong-Hyun; Ko, Dong-Sik; Baek, Tae-Jong; Lee, Sang-Jin; Kim, Jin-Ho; Lee, Seong-Dae; Kim, Mi-Ra; Chae, Yeon-Sik; Kathalingam, Adaikalam; Rhee, Jin-Koo

    2010-11-01

    In this work, we have designed and fabricated the GaAs Gunn diodes for a 94 GHz waveguide voltage controlled oscillator (VCO) which is one of the important parts in a frequency modulated continuous wave (FMCW) radar application. For fabrication of the high power GaAs Gunn diodes, we adopted a graded gap injector which enhances the output power and conversion efficiency by effectively removing the dead-zone. We have measured RF characteristics of the fabricated GaAs Gunn diodes. The operating current, oscillation frequency, and output power of the fabricated GaAs Gunn diodes are presented as a function of the anode diameters. The operating current increases with anode diameters, whereas the oscillation frequency decreases. The higher oscillation frequency was obtained from 60 µm anode diameters of the fabricated Gunn GaAs diodes and higher power was obtained from 68 µm. Also, for application of the 94 GHz FMCW radar system, we have fabricated the 94 GHz waveguide VCO. From the fabricated GaAs Gunn diodes of anode diameter of 60 µm, we have obtained the improved VCO performance.

  3. Perinatal hypothyroidism modulates antioxidant defence status in the developing rat liver and heart.

    Science.gov (United States)

    Zhang, Hongmei; Dong, Yan; Su, Qing

    2017-02-01

    In the present study, we investigated oxidative stress parameters and antioxidant defence status in perinatal hypothyroid rat liver and heart. We found that the proteincarbonyl content did not differ significantly between the three groups both in the pup liver and in the heart. The OH˙ level was significantly decreased in the hypothyroid heart but not in the liver compared with controls. A slight but not significant decrease in SOD activity was observed in both perinatal hypothyroid liver and heart. A significantly increased activity of CAT was observed in the liver but not in the heart of hypothyroid pups. The GPx activity was considerably increased compared with controls in the perinatal hypothyroid heart and was unaltered in the liver of hypothyroid pups. We also found that vitamin E levels in the liver decreased significantly in hypothyroidism and were unaltered in the heart of perinatal hypothyroid rats. The GSH content was elevated significantly in both hypothyroid liver and heart. The total antioxidant capacity was higher in the liver of the hypothyroid group but not in the hypothyroid heart. Thyroxine replacement could not repair the above changes to normal. In conclusion, perinatal hypothyroidism modulates the oxidative stress status of the perinatal liver and heart.

  4. Analysis of Factors Influencing the Development of Xerostomia during Intensity-Modulated Radiotherapy

    Science.gov (United States)

    Randall, Ken; Stevens, Jason; Yepes, Juan Fernando; Randall, Marcus E.; Kudrimoti, Mahesh; Feddock, Jonathan; Xi, Jing; Kryscio, Richard J.; Miller, Craig S.

    2013-01-01

    OBJECTIVES Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. METHODS A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week two and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. RESULTS HNC subjects experienced mean SSFR decline of 36% by visit two (N=27; p=0.012) and 57% by visit three (N=20; p=0.0004), Concentrations of calcium and MUC5b increased, but not significantly during IMRT (p>0.05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (p<0.04) and linear mixed models (p<0.0001). CONCLUSIONS Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia. PMID:23523462

  5. A Learning Module for BA Students to Develop ICT Skills for their Learning Activities | Un module de formation visant le développement des compétences TICE chez les étudiants en baccalauréat

    Directory of Open Access Journals (Sweden)

    Hervé Platteaux

    2015-11-01

    Full Text Available This case illustrates the process of developing a learning module to support BA students in their use of ICT (Information and Communication Technology tools in their learning. At the university where this case occurred, the skill level of ICT use among students in a learning context was very heterogeneous. The E-learning Competency Centre, or ECC, which was in charge of techno-pedagogical development at the institution, created a hybrid learning module that offered students learning materials and activities with both face-to-face workshops and online tutorials for autonomous learning. The students were able to choose subjects they wanted to learn "à la carte" by taking tutorials on their own and/or by participating in face-to-face workshops. The module described in this case is currently under construction. The design phase of this project is the focus of this case study.

  6. The effect of plasma radius and profile on the development of self-modulation instability of electron bunches

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Y. [University of Southern California, Los Angeles, California 90089 (United States); Vieira, J.; Amorim, L. D. [GoLP/Instituto de Plasmas e Fusão Nuclear Instituto Superior Técnico (IST), Lisbon (Portugal); Mori, W. [University of California, Los Angeles, California 90095 (United States); Muggli, P. [University of Southern California, Los Angeles, California 90089 (United States); Max Planck Institute for Physics, Munich (Germany)

    2014-05-15

    Plasmas available for plasma wakefield accelerator experiments may have longitudinal and transverse density profiles that could affect the outcome of an experiment. This paper investigates the effect of plasmas with finite radius and inhomogeneous transverse density profiles on the wakefield excitation and the self-modulation instability (SMI) development in overdense plasmas. We focus here on the case of an electron bunch. Simulation results show that such plasmas generate larger focusing force for the propagating electron beam and therefore higher growth rate for the SMI. Although the initial accelerating field (E{sub z}) amplitude is lower in such plasmas, the increased focusing force can dominate the development trend of the SMI, i.e., larger saturated E{sub z} amplitude can be reached over similar plasma lengths.

  7. Development and verification of hardware for life science experiments in the Japanese Experiment Module "Kibo" on the International Space Station.

    Science.gov (United States)

    Ishioka, Noriaki; Suzuki, Hiromi; Asashima, Makoto; Kamisaka, Seiichiro; Mogami, Yoshihiro; Ochiai, Toshimasa; Aizawa-Yano, Sachiko; Higashibata, Akira; Ando, Noboru; Nagase, Mutsumu; Ogawa, Shigeyuki; Shimazu, Toru; Fukui, Keiji; Fujimoto, Nobuyoshi

    2004-03-01

    Japan Aerospace Exploration Agency (JAXA) has developed a cell biology experiment facility (CBEF) and a clean bench (CB) as a common hardware in which life science experiments in the Japanese Experiment Module (JEM known as "Kibo") of the International Space Station (ISS) can be performed. The CBEF, a CO2 incubator with a turntable that provides variable gravity levels, is the basic hardware required to carry out the biological experiments using microorganisms, cells, tissues, small animals, plants, etc. The CB provides a closed aseptic operation area for life science and biotechnology experiments in Kibo. A phase contrast and fluorescence microscope is installed inside CB. The biological experiment units (BEU) are designed to run individual experiments using the CBEF and the CB. A plant experiment unit (PEU) and two cell experiment units (CEU type1 and type2) for the BEU have been developed.

  8. Ultra-Wideband Optical Modulation Spectrometer (OMS) Development: Study of the Optical Setup of a Wide-Band Optical Modulation Spectrometer

    Science.gov (United States)

    Tolls, Volker; Stringfellow, Guy (Technical Monitor)

    2001-01-01

    The purpose of this study is to advance the design of the optical setup for a wide-band Optical Modulation Spectrometer (OMS) for use with astronomical heterodyne receiver systems. This report describes the progress of this investigation achieved from March until December 2001.

  9. Thruster Module

    Science.gov (United States)

    Andersson, G.

    2015-09-01

    The thruster module described in this paper provides a low but controlled acceleration in a mission which would normally be labelled “microgravity”. The first mission was Cryofenix, where tanks containing liquid hydrogen were used in the experiment. The experiment utilizing the low acceleration is using liquids and requires a precise acceleration profile throughout the mission. Acceleration obtained by payload rotation is not feasible due to that the transversal forces required to change the acceleration will cause undesired liquid turbulence. In order to satisfy the experiment requirements a thruster module was developed by SSC for the Cryofenix mission funded by CNES. The Cryofenix mission had a payload weight of 380 kg and an apogee of about 260 km. The module produces a controlled thrust in flight direction by means of a cold gas system.

  10. Handling Uncertainties within R&D Modules of a developing Technology

    DEFF Research Database (Denmark)

    Pedersen, Jørgen Lindgaard; Perunovic, Zoran

    2004-01-01

    The paper deals with uncertainties that may arise from previously modularised R&D effort of a new developing technology. The case of teh insulin development technologies has been presented through modularisation of pancreatic extracts, semi-synthesis, and recombinant DNA technologies.Desk research...

  11. Development of a Video Tape Teaching Module To Facilitate the Patient's Understanding of Chemotherapy.

    Science.gov (United States)

    Vernot, Gertrude W.

    A practicum project was conducted to develop a method to enhance the knowledge base of targeted adult cancer patients entering into a treatment plan that included chemotherapy. The educational component necessary for informed consent by the patient had not been consistent; therefore, a videotape was developed containing general information common…

  12. Fine-scale temperature fluctuation and modulation of Dirofilaria immitis larval development in Aedes aegypti.

    Science.gov (United States)

    Ledesma, Nicholas; Harrington, Laura

    2015-04-15

    We evaluated degree-day predictions of Dirofilaria immitis development (HDU) under constant and fluctuating temperature treatments of equal average daily temperature. Aedes aegypti mosquitoes were infected with D. immitis microfilariae and parasite development was recorded at set time points in dissected mosquitoes. Time to L3 development in Malpighian tubules and detection in mosquito heads was shorter for larvae experiencing a daily regime of 19±9°C than larvae at constant 19°C; larval development rate in Malpighian tubules was slower in fluctuating regimes maintained above the 14°C developmental threshold than larvae under constant temperatures. We showed that hourly temperature modeling more accurately predicted D. immitis development to infective L3 stage. Development time differed between fluctuating and constant temperature treatments spanning the 14°C development threshold, implicating a physiological basis for these discrepancies. We conclude that average daily temperature models underestimate L3 development-and consequently dog heartworm transmission risk-at colder temperatures, and spatiotemporal models of D. immitis transmission risk should use hourly temperature data when analyzing high daily temperature ranges spanning 14°C. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  13. ESD practice through global approach -7-year practices of developing science lessen modules and fostering integrated decision making ability-

    Science.gov (United States)

    Kajiyama, Kosei

    2016-04-01

    Hiroshima University High School (HUHS) has devised and carried out overseas exchange programs on ESD issues for 7 years. These programs have been carried out as a part of a government-aided project called SSH (Super Science High School) *1. To start with, we had cooperative study program with a school in Germany in 2009, and next year with a school in Korea, and then gradually have expanded the cooperative schools. Since 2013, we have worked with schools in four countries; Korea, Thailand, Czech and Germany. Science lesson modules here refers to an assembly of a set of lessons, newly developed and improved for the project. These modules characteristically require the students to make decisions by themselves on given problems. In the course of the decision making, students learn what kind of data or facts should be presented as evidence and how they can make their decisions known to others. Among several modules we have designed, the one introduced here deals with the use of solar energy, which we carried out with a school in Korea in 2014-2015. It also includes lessons of the fuel cells using energy from hydrogen gas generated by solar cells. It aims to develop global human resources through carefully planned activities. First, the students of both schools make mixed groups and conduct experiments in physics, chemistry or biology on a given problem related to solar energy. Then they discuss in groups using data obtained from the experiments and through the Internet as evidence. After the thorough discussion, each group gives a presentation on their decision. The analysis of the presentations and the questionnaire to the students revealed the following points: 1) Students have come to have multidimensional perspectives on the utilization of solar energy. 2) Students have come to combine the results of different experiments when making decisions. 3) Students have developed flexible attitudes toward other cultures. 4) Students have developed communication skills in

  14. Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

    Directory of Open Access Journals (Sweden)

    Stefanou Nikolaos

    2010-08-01

    Full Text Available Abstract Background Numerous epidemiological studies have documented that obesity is associated with hepatocellular carcinoma (HCC. The aim of this study was to investigate the biological actions regulated by leptin, the obesity biomarker molecule, and its receptors in HCC and the correlation between leptin and human telomerase reverse transcriptase (hTERT, a known mediator of cellular immortalization. Methods We investigated the relationship between leptin, leptin receptors and hTERT mRNA expression in HCC and healthy liver tissue samples. In HepG2 cells, chromatin immunoprecipitation assay was used to study signal transducer and activator of transcription-3 (STAT3 and myc/mad/max transcription factors downstream of leptin which could be responsible for hTERT regulation. Flow cytometry was used for evaluation of cell cycle modifications and MMP1, 9 and 13 expression after treatment of HepG2 cells with leptin. Blocking of leptin's expression was achieved using siRNA against leptin and transfection with liposomes. Results We showed, for the first time, that leptin's expression is highly correlated with hTERT expression levels in HCC liver tissues. We also demonstrated in HepG2 cells that leptin-induced up-regulation of hTERT and TA was mediated through binding of STAT3 and Myc/Max/Mad network proteins on hTERT promoter. We also found that leptin could affect hepatocellular carcinoma progression and invasion through its interaction with cytokines and matrix mettaloproteinases (MMPs in the tumorigenic microenvironment. Furthermore, we showed that histone modification contributes to leptin's gene regulation in HCC. Conclusions We propose that leptin is a key regulator of the malignant properties of hepatocellular carcinoma cells through modulation of hTERT, a critical player of oncogenesis.

  15. Development of n-in-p pixel modules for the ATLAS upgrade at HL-LHC

    Science.gov (United States)

    Macchiolo, A.; Nisius, R.; Savic, N.; Terzo, S.

    2016-09-01

    Thin planar pixel modules are promising candidates to instrument the inner layers of the new ATLAS pixel detector for HL-LHC, thanks to the reduced contribution to the material budget and their high charge collection efficiency after irradiation. 100-200 μm thick sensors, interconnected to FE-I4 read-out chips, have been characterized with radioactive sources and beam tests at the CERN-SPS and DESY. The results of these measurements are reported for devices before and after irradiation up to a fluence of 14 ×1015 neq /cm2 . The charge collection and tracking efficiency of the different sensor thicknesses are compared. The outlook for future planar pixel sensor production is discussed, with a focus on sensor design with the pixel pitches (50×50 and 25×100 μm2) foreseen for the RD53 Collaboration read-out chip in 65 nm CMOS technology. An optimization of the biasing structures in the pixel cells is required to avoid the hit efficiency loss presently observed in the punch-through region after irradiation. For this purpose the performance of different layouts have been compared in FE-I4 compatible sensors at various fluence levels by using beam test data. Highly segmented sensors will represent a challenge for the tracking in the forward region of the pixel system at HL-LHC. In order to reproduce the performance of 50×50 μm2 pixels at high pseudo-rapidity values, FE-I4 compatible planar pixel sensors have been studied before and after irradiation in beam tests at high incidence angle (80°) with respect to the short pixel direction. Results on cluster shapes, charge collection and hit efficiency will be shown.

  16. Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development.

    Science.gov (United States)

    Gennari, Luigi; Merlotti, Daniela; Valleggi, Fabrizio; Martini, Giuseppe; Nuti, Ranuccio

    2007-01-01

    Selective estrogen receptor modulators (SERMs) are structurally different compounds that interact with intracellular estrogen receptors in target organs as estrogen receptor agonists and antagonists. These drugs have been intensively studied over the past decade and have proven to be a highly versatile group for the treatment of different conditions associated with aging, including hormone-responsive cancer and osteoporosis. Tamoxifen and toremifene are currently used to treat advanced breast cancer and also have beneficial effects on bone mineral density and serum lipids in postmenopausal women. Raloxifene is the only SERM approved worldwide for the prevention and treatment of postmenopausal osteoporosis and vertebral fractures. However, although these SERMs have many benefits, they may also be responsible for some potentially very serious adverse effects, such as thromboembolic disorders and, in the case of tamoxifen, uterine cancer. These adverse effects represent a major concern given that long-term therapy is required to prevent osteoporosis. Moreover, both preclinical and clinical reports suggest that tamoxifen, toremifene and raloxifene are considerably less potent than estrogen. The search for the 'ideal' SERM, which would have estrogenic effects on bone and serum lipids, neutral effects on the uterus, and antiestrogenic effects on breast tissue, but none of the adverse effects associated with current therapies, is currently under way. Ospemifene, lasofoxifene, bazedoxifene and arzoxifene, which are new SERM molecules with potential greater efficacy and potency than previous SERMs, are currently under investigation for use in the treatment and prevention of osteoporosis. These drugs have been shown to be comparably effective to conventional hormone replacement therapy in animal models of osteoporosis, with potential indications for an improved safety profile. Clinical efficacy data from ongoing phase III trials are awaited so that a true understanding of

  17. Development of highly efficient large-area a-Si PV module. Final report; Entwicklung hocheffizienter grossflaechiger a-Si-Photovoltaikmodule. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, H.; Frammelsberger, W.; Lechner, P.; Geyer, R.; Schade, H.; Psyk, W.

    1998-06-01

    This project was focused on the development of stable PV modules based on a-Si, and on the process transfer from a laboratory scale to a large-area production level. Central to these efforts is the economic relevance that requires reasonable module efficiencies obtained with high throughput and yield. Our modules contain p-i-n/p-i-n (a-Si/a-Si) cell structures that are based on deposition procedures developed at ISI, i.e. low-temperature deposition and high hydrogen dilution for the top cell, and microdoping between the p-layer and the buffer layer for the cottom cell. The maximum stabilized (1800 h) module efficiency obtained by production-relevant processes is 6.5% for the aperture area of 5445 cm{sup 2}. (orig.) [Deutsch] Die Arbeiten im Rahmen des Projekts konzentrierten sich auf die Entwicklung moeglicht stabiler a-Si-PV-Module und auf die Umsetzung vorhandener Labortechniken in einen industriellen Fertigungsmassstab. Mitbestimmend fuer die Entwicklungsarbeiten war die kommerzielle Relevanz, die brauchbare Modulleistungen verknuepft mit hohem Durchsatz bei hoher Ausbeute. Die Basis fuer unsere jetzige Zellstruktur im Modul sind die a-Si/a-Si-(p-i-n/p-i-n)-Technologie und die Technologiekonzepte des ISI (Tieftemperaturabscheidung bei hoher H-Verduennung fuer die Topzelle sowie Feindotierung des Uebergangs von der p-Schicht in den Puffer hinein fuer die Bottomzelle). Das beste mit einem fertigungsrelevanten Prozess hergestellte Modul erreicht nach 1800 h Lichtalterung einen stabilisierten Aperturwirkungsgrad von 6.5%. (orig.)

  18. Fine-scale temperature fluctuation and modulation of Dirofilaria immitis larval development in Aedes aegypti

    Science.gov (United States)

    Ledesma, Nicholas; Harrington, Laura

    2015-01-01

    We evaluated degree-day predictions of Dirofilaria immitis development (HDU) under constant and fluctuating temperature treatments of equal average daily temperature. Aedes aegypti mosquitoes were infected with D. immitis microfilariae and parasite development was recorded at set time points in dissected mosquitoes. Time to L3 development in Malpighian tubules and detection in mosquito heads was shorter for larvae experiencing a daily regime of 19±9°C than larvae at constant 19°C; larval development rate in Malpighian tubules was slower in fluctuating regimes maintained above the 14°C developmental threshold than larvae under constant temperatures. We showed that hourly temperature modeling more accurately predicted D. immitis development to infective L3 stage. Development time differed between fluctuating and constant temperature treatments spanning the 14°C development threshold, implicating a physiological basis for these discrepancies. We conclude that average daily temperature models underestimate L3 development—and consequently dog heartworm transmission risk—at colder temperatures, and spatio-temporal models of D. immitis transmission risk should use hourly temperature data when analyzing high daily temperature ranges spanning 14°C. PMID:25747489

  19. Development of a high-resolution detection module for the INSERT SPECT/MRI system

    Energy Technology Data Exchange (ETDEWEB)

    Busca, Paolo; Fiorini, Carlo; Butt, Arslan D; Occhipinti, Michele; Quaglia, Riccardo; Trigilio, Paolo [Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Via Golgi 40, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Milano, Via Celoria 16, 20133 Milano (Italy); Nemeth, Gabor; Major, Peter; Bukki, Tamas; Nagy, Kalman [Mediso Medical Imaging Systems, Alsotorokvesz 14, H-1022 Budapest (Hungary); Piemonte, Claudio; Ferri, Alessandro; Gola, Alberto [Fondazione Bruno Kessler (FBK), Via Sommarive, 18, 38123 Trento (Italy); Rieger, Jan [MRI.TOOLS GmbH, Robert-Roessle-Str. 10, 13125 Berlin (Germany); Niendorf, Thoralf [MRI.TOOLS GmbH, Robert-Roessle-Str. 10, 13125 Berlin (Germany); Berlin Ultrahigh Field Facility (B.UniversityF.F.), Max-Delbrueck-Center for Molecular Medicine, Berlin (Germany)

    2014-07-29

    A new multi-modality imaging tool is under development in the framework of the INSERT (Integrated SPECT/MRI for Enhanced Stratification in Radio-chemo Therapy) project, supported by the European Community. The final goal is to develop a custom SPECT apparatus that can be used as an insert for commercially available MRI systems. INSERT is expected to offer more effective and earlier diagnosis with potentially better outcome in survival for the treatment of brain tumors, primarily glioma. Two SPECT prototypes are being developed, one dedicated to preclinical imaging (7 and 9.4 T), the second one dedicated to clinical imaging (3 T).

  20. Proceedings: Twenty years of energy policy: Looking toward the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    In 1973, immediately following the Arab Oil Embargo, the Energy Resources Center, University of Illinois at Chicago initiated an innovative annual public service program called the Illinois Energy Conference. The objective was to provide a public forum each year to address an energy or environmental issue critical to the state, region and nation. Twenty years have passed since that inaugural program, and during that period we have covered a broad spectrum of issues including energy conservation nuclear power, Illinois coal, energy policy options, natural gas, alternative fuels, new energy technologies, utility deregulation and the National Energy Strategy.

  1. UTILITY OF MECHANISTIC MODELS FOR DIRECTING ADVANCED SEPARATIONS RESEARCH & DEVELOPMENT ACTIVITIES: Electrochemically Modulated Separation Example

    Energy Technology Data Exchange (ETDEWEB)

    Schwantes, Jon M.

    2009-06-01

    The objective for this work was to demonstrate the utility of mechanistic computer models designed to simulate actinide behavior for use in efficiently and effectively directing advanced laboratory R&D activities associated with developing advanced separations methods.

  2. Membrane module and process development for monopolar and bipolar membrane electrodialysis

    OpenAIRE

    Balster, Jörg Henning

    2006-01-01

    This thesis aims to develop more efficient monopolar and bipolar membrane electrodialysis processes. Three main topics have been investigated: 1. Membrane selectivity 2. Concentration polarisation 3. Membrane scaling and fouling

  3. Development of paper-based wireless communication modules for point-of-care diagnostic applications

    CSIR Research Space (South Africa)

    Smith, Suzanne

    2016-09-01

    Full Text Available . Printing of radio frequency identification antennas and electronic circuitry for sensing on paper are presented, with read out of the results using a radio frequency identification reader illustrated, demonstrating the feasibility of developing integrated...

  4. Twisted Gastrulation as a BMP Modulator during Mammary Gland Development and Tumorigenesis

    Science.gov (United States)

    2014-05-01

    preplacodal ectoderm specification (Kwon et al., 2010), and hair follicle morphogenesis (Kobielak et al., 2003). In the MG, GATA-3 deficiency...BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development. 2007...pubertal duct cDNA we measured a significant reduction in downstream targets such as Id-2, Msx1, Msx2 and Gata-3 in the Twsg1-/- MG (Appendix 1

  5. Microdata Simulation Modeling After Twenty Years.

    Science.gov (United States)

    Haveman, Robert H.

    1986-01-01

    This article describes the method and the development of microdata simulation modeling over the past two decades. After tracing a brief history of this evaluation method, its problems and prospects are assessed. The effects of this research method on the development of the social sciences are examined. (JAZ)

  6. Development of microfluidic modules for DNA purification via phenol extraction and analyte concentration using transverse electrokinetics

    Science.gov (United States)

    Morales, Mercedes C.

    bounding walls. The miniaturization of DNA phenol extraction and the novel electrokinetic trapping techniques presented in this research are the initial steps towards an efficient DNA sample preparation chip which could be integrated with post-extraction DNA manipulations for genomic analysis modules such as capillary electrophoretic separations.

  7. The Dialectics of Discrimination in the Twenty-First Century

    Directory of Open Access Journals (Sweden)

    John Stone

    2007-12-01

    Full Text Available This article explores some of the latest developments in the scholarship on race relations and nationalism that seek to address the impact of globalization and the changed geo-political relations of the first decade of the twenty-first century. New patterns of identification, some of which challenge existing group boundaries and others that reinforce them, can be seen to flow from the effects of global market changes and the political counter-movements against them. The impact of the “war on terrorism”, the limits of the utility of hard power, and the need for new mechanisms of inter-racial and inter-ethnic conflict resolution are evaluated to emphasize the complexity of these group relations in the new world disorder.

  8. Current status of technology development for fabrication of Indian Test Blanket Module (TBM) of ITER

    Energy Technology Data Exchange (ETDEWEB)

    Jayakumar, T., E-mail: tjk@igcar.gov.in [Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam 603102 (India); Rajendra Kumar, E. [TBM Division, Institute for Plasma Research (IPR), Bhat, Gandhinagar 382428 (India)

    2014-10-15

    Highlights: • Status of technology developments for Indian TBM to be installed in ITER is presented. • Procedure development for EB, laser and laser-hybrid welding of RAFM steel presented. • Filler wires for RAFM steel for TIG, NG-TIG and laser-hybrid welding have been developed. • Feasibility of production of channel plate by HIP technology has been demonstrated. - Abstract: Ever since India decided to install its Lead-Lithium Ceramic Breeder (LLCB) TBM in ITER, various technologies for fabrication of Indian TBM are being pursued by IPR and IGCAR, in collaboration with various research laboratories in India. Welding consumables for joining India specific RAFM steels (IN-RAFMS), procedures for hot isostatic pressing, electron beam welding, laser and laser-hybrid welding have been developed. Considering the complex nature and limited access available for inspection, innovative inspection procedures that involved use of phased array ultrasonic and C-scan imaging are also being pursued. This paper presents the current status of these developments and provides a roadmap for the future activities planned in realizing Indian TBM for testing in ITER.

  9. BP8, a novel peptide from avian immune system, modulates B cell developments.

    Science.gov (United States)

    Liu, Xiao-Dong; Zhou, Bin; Feng, Xiu-Li; Cao, Rui-Bing; Chen, Pu-Yan

    2014-12-01

    The bursa of Fabricius (BF) is the key humoral immune organ unique to birds, and is critical for early B-lymphocyte proliferation and differentiation. However, the molecular basis and mechanisms through which the BF regulates B cell development are not fully understood. In this study, we isolated and identified a new bursal peptide (BP8, AGHTKKAP) by RP-HPLC and MALDI-TOF-MS. BP8 promoted colony-forming pre-B formation, bound B cell precursor, regulated B cell development in vitro as well as in vivo, upstream of the EBF-E2A-Pax5 regulatory complex and increased immunoglobulin secretion. These data revealed a bursal-derived multifunctional factor BP8 as a novel biomaterial which is essential for the development of the immune system. This study elucidates further the mechanisms involved in humoral immune system and has implications in treating human diseases.

  10. Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

    DEFF Research Database (Denmark)

    Mease, Philip J; Clauw, Daniel J; Christensen, Robin

    2011-01-01

    Following development of the core domain set for fibromyalgia (FM) in Outcome Measures in Rheumatology Clinical Trials (OMERACT) meetings 7 to 9, the FM working group has progressed toward the development of an FM responder index and a disease activity score based on these domains, utilizing...... outcome indices of these domains from archived randomized clinical trials in FM. Possible clinical domains that could be included in a responder index and disease activity score include pain, fatigue, sleep disturbance, cognitive dysfunction, mood disturbance, tenderness, stiffness, and functional...... spondylitis represents heuristic models for our work, but FM is challenging in that there is no clear algorithm of treatment that defines disease activity based on treatment decisions, nor are there objective markers that define thresholds of severity or response to treatment. The process of developing...

  11. DESIGN AND DEVELOPMENT OF A RECOMMENDER SYSTEM FOR E-LEARNING MODULES

    Directory of Open Access Journals (Sweden)

    Baseera

    2014-01-01

    Full Text Available Extensive literature review revealed that, different recommender systems for E-learning were developed. A preliminary version of the development was undertaken and evaluated in an experiment during an introduction psychology course in an open university. The activities were integrated in to a model which operates on a network. No curriculum structure was assigned and the users were allowed to undergo learning activities in any order they wanted. Though voluminious work was reported on establishing bench marks for learning process on a wide range basis, there are only discrete references on developing a system comprising of a web-based typical learning environment which includes many aspects of learning such as course content delivery tools, synchronous and asynchronous conferencing systems, quiz models, grade reporting systems, creation of virtual class rooms. An attempt is made in this study to design and develop a Recommender System (RS, in the form of a software agent giving recommendations based on the previous observations. The developed RS suggests the applications of web mining techniques resulting in, on-line learning activities and improving the course material navigation. The proposed RS combines a top down ontology based recommendation techniques clubbed with bottom-up techniques. Both techniques were combined in the RS, which decided, which of the techniques is more suitable for the current situation in which a learner works. Finally the present work provides for recommendation strategies for a personal RS in E-learning models for life long learners. The major contribution of the present work lies, in designing and developing a RS in the form of a software agent, incorporating web mining techniques resulting in, on-line learning activities, such as course content delivery tools, conferencing systems, creation of virtual class rooms.

  12. Rapid-X - An FPGA Development Toolset Using a Custom Simulink Library for MTCA.4 Modules

    Science.gov (United States)

    Prędki, Paweł; Heuer, Michael; Butkowski, Łukasz; Przygoda, Konrad; Schlarb, Holger; Napieralski, Andrzej

    2015-06-01

    The recent introduction of advanced hardware architectures such as the Micro Telecommunications Computing Architecture (MTCA) caused a change in the approach to implementation of control schemes in many fields. The development has been moving away from traditional programming languages ( C/C++), to hardware description languages (VHDL, Verilog), which are used in FPGA development. With MATLAB/Simulink it is possible to describe complex systems with block diagrams and simulate their behavior. Those diagrams are then used by the HDL experts to implement exactly the required functionality in hardware. Both the porting of existing applications and adaptation of new ones require a lot of development time from them. To solve this, Xilinx System Generator, a toolbox for MATLAB/Simulink, allows rapid prototyping of those block diagrams using hardware modelling. It is still up to the firmware developer to merge this structure with the hardware-dependent HDL project. This prevents the application engineer from quickly verifying the proposed schemes in real hardware. The framework described in this article overcomes these challenges, offering a hardware-independent library of components that can be used in Simulink/System Generator models. The components are subsequently translated into VHDL entities and integrated with a pre-prepared VHDL project template. Furthermore, the entire implementation process is run in the background, giving the user an almost one-click path from control scheme modelling and simulation to bit-file generation. This approach allows the application engineers to quickly develop new schemes and test them in real hardware environment. The applications may range from simple data logging or signal generation ones to very advanced controllers. Taking advantage of the Simulink simulation capabilities and user-friendly hardware implementation routines, the framework significantly decreases the development time of FPGA-based applications.

  13. Development of Ethnoscience Approach in The Module Theme Substance Additives to Improve the Cognitive Learning Outcome and Student’s entrepreneurship

    Science.gov (United States)

    Sudarmin; Febu, R.; Nuswowati, M.; Sumarni, W.

    2017-04-01

    Ethnoscience approach is an interesting research today. The purpose of this research is to develop approaches ethnoscience and modules ethnoscience theme additives based ethnoscience; as well as assess the feasibility and effectiveness of module theme additives based ethnoscience to improve learning outcomes and the entrepreneurial character of students. This type of research is the Research and Development (R & D). In this research consist of four stages, namely define, design, development and implementation. The subjects of this study were students of the School of MTs Maarif NU Brebes. Data were analyzed by descriptive qualitative and quantitative. The results showed that ethnoscience approach and the module theme substance additives used declared worthy of National Education Standards Agency (BNSP) with an average percentage of validation on the feasibility aspect of the content, language feasibility, and feasibility of presenting respectively for 94.3%, 86 % and 92% and a very decent entry criteria. The effect of the application modules substance additive based ethnoscience can improve on the cognitive learning classical amounted to 90.63%, and increased learning outcomes category was based on the scores of N-gain. Influence ethnoscience approach application and module theme substances additives based ethnoscience able to improve the entrepreneurial character of students. Based on the results of this study concluded that the ethnoscience approach and module theme substance additives based ethnoscience effective to improve learning outcomes and students’ entrepreneurship.

  14. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development

    DEFF Research Database (Denmark)

    Knopp, Matthias Manne; Löbmann, Korbinian; Elder, David P.

    2016-01-01

    of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze...

  15. Is an Online Learning Module an Effective Way to Develop Information Literacy Skills?

    Science.gov (United States)

    Johnston, Nicole

    2010-01-01

    Information literacy is an integral generic skill or graduate attribute in higher education, with many higher education institutions developing information literacy policies and including information literacy in graduate attribute policies. Barrie (2007) notes that universities around the world are increasingly concerned with ensuring that their…

  16. A New Approach to Developing Interactive Software Modules through Graduate Education

    Science.gov (United States)

    Sanders, Nathan E.; Faesi, Chris; Goodman, Alyssa A.

    2014-01-01

    Educational technology has attained significant importance as a mechanism for supporting experiential learning of science concepts. However, the growth of this mechanism is limited by the significant time and technical expertise needed to develop such products, particularly in specialized fields of science. We sought to test whether interactive,…

  17. Consecutive Course Modules Developed with Simple Materials to Facilitate the Learning of Basic Concepts in Astronomy

    Science.gov (United States)

    Okulu, Hasan Zuhtu; Oguz-Unver, Ayse

    2015-01-01

    From the perspective of teaching, the huge natural laboratory that astronomy provides constitutes the most prominent connection between astronomy and other branches of science. The purpose of this research was to provide educators with activities of observation using simple materials that were developed to facilitate the teaching of basic concepts…

  18. MT1-MMP-mediated basement membrane remodeling modulates renal development

    Energy Technology Data Exchange (ETDEWEB)

    Riggins, Karen S.; Mernaugh, Glenda [Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Su, Yan; Quaranta, Vito [Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Koshikawa, Naohiko; Seiki, Motoharu [Division of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan); Pozzi, Ambra [Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Research Medicine, Veterans Affairs Hospital, Nashville, TN 37232 (United States); Zent, Roy, E-mail: roy.zent@vanderbilt.edu [Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Department of Research Medicine, Veterans Affairs Hospital, Nashville, TN 37232 (United States)

    2010-10-15

    Extracellular matrix (ECM) remodeling regulates multiple cellular functions required for normal development and tissue repair. Matrix metalloproteinases (MMPs) are key mediators of this process and membrane targeted MMPs (MT-MMPs) in particular have been shown to be important in normal development of specific organs. In this study we investigated the role of MT1-MMP in kidney development. We demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching morphogenesis and a severe proliferation defect. The kidneys of MT1-MMP-null mice have increased deposition of collagen IV, laminins, perlecan, and nidogen and the phenotype is independent of the MT-1MMP target, MMP-2. Utilizing in vitro systems we demonstrated that MTI-MMP proteolytic activity is required for renal tubule cells to proliferate in three dimensional matrices and to migrate on collagen IV and laminins. Together these data suggest an important role for MT1-MMP in kidney development, which is mediated by its ability to regulate cell proliferation and migration by proteolytically cleaving kidney basement membrane components.

  19. Assessment of Animated Self-Directed Learning Activities Modules for Children's Number Sense Development

    Science.gov (United States)

    Yang, Der-Ching; Li, Mao-Neng

    2013-01-01

    The purpose of this study was to examine the relative effectiveness of two different learning modes; namely, a computer animation self-directed learning approach and a paper version of the self-directed learning approach, to 5th-graders' number sense development. Two 5th-grade classes, 30 students each, were selected from a public elementary…

  20. The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity

    DEFF Research Database (Denmark)

    Madsen, Lise; Kristiansen, Karsten

    2010-01-01

    Adipose tissue plays a pivotal role in whole body energy homeostasis. In this review, we summarize knowledge of the seemingly paradoxical roles of insulin and cyclic adenosine monophosphate (cAMP) signaling in adipocyte differentiation and function, emphasizing the interplay between the two...... branches of cAMP signaling, the canonical protein kinase A-dependent pathways and the novel exchange protein activated by cAMP (Epac)-dependent pathways, and insulin signaling. We discuss how macronutrients via changes in the balance between insulin- and cAMP-dependent signaling can affect the development...... of obesity by changing energy expenditure and/or feed efficiency. We review results demonstrating how the balance between different classes of carbohydrates and proteins modulates the obesigenic action of saturated as well as unsaturated fatty acids pointing to insulin as a key determinant in the regulation...

  1. Development of a CO2 Sequestration Module by Integrating Mineral Activation and Aqueous Carbonation

    Energy Technology Data Exchange (ETDEWEB)

    George Alexander; Parvana Aksoy; John Andresen; Mercedes Maroto-Valer; Harold Schobert

    2006-08-14

    process to design an integrated CO{sub 2} sequestration module. A parametric study was conducted to optimize conditions for mineral activation, in which serpentine and sulfuric acid were reacted. The study focused on the effects of varying the acid concentration, particle size, and reaction time. The reaction yield was as high as 48% with a 5 M acid concentration, with lower values directly corresponding to lower acid concentrations. Significant improvements in the removal of moisture, as well as in the dissolution, can be realized with comminution of particles to a D{sub 50} less than 125 ?m. A minimum threshold of 3 M concentration of sulfuric acid was found to exist in terms of removal of moisture from serpentine. The effect of reaction time was insignificant. The treated serpentine had low BET surface areas. Results demonstrated that acid concentration provided primary control on the dissolution via the removal of water, which is closely correlated with the extraction of magnesium from serpentine. Single-variable experimentation demonstrated dissolution enhancements with increased reaction time and temperature. An increase in magnesium dissolution of 46% and 70%, relative to a baseline test, occurred for increased reaction time and temperature, respectively. In addition to the challenges presented by the dissolution of serpentine, another challenge is the subsequent carbonation of the magnesium ions. A stable hydration sphere for the magnesium ion reduces the carbonation kinetics by obstructing the formation of the carbonation products. Accordingly, this research has evaluated the solubility of carbon dioxide in aqueous solution, the interaction between the dissociation products of carbon dioxide, and the carbonation potential of the magnesium ion.

  2. The European ITER Test Blanket Modules: Current status of fabrication technologies development and a way forward

    Energy Technology Data Exchange (ETDEWEB)

    Zmitko, Milan, E-mail: milan.zmitko@f4e.europa.eu [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Galabert, Jose [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain); Thomas, Noël [ATMOSTAT, F-94815 Villejuif (France); Forest, Laurent [CEA-Saclay, DEN, DM2S, SEMT, F-91191 Gif-sur-Yvette (France); Bucci, Philippe; Cogneau, Laurence [CEA-DRT, 38000 Grenoble (France); Rey, Jörg; Neuberger, Heiko [Karlsruhe Institute of Technology (KIT), Postfach 3640, Karlsruhe (Germany); Poitevin, Yves [Fusion for Energy (F4E), Josep Pla 2, Barcelona (Spain)

    2015-10-15

    Highlights: • Significant progress on development of welding procedures for European TBM achieved. • Fabrication processes feasibility based on diffusion and fusion welding demonstrated. • TBM box assembly welding scenarios investigated and welding scenarios identified. • Future qualification of pF/WPS proposed through realization of a number of QMUs. - Abstract: The paper reviews fabrication technologies and procedures applied for manufacturing of the TBM sub-components, like, HCLL and HCPB cooling plates, HCLL/HCPB stiffening plates, and HCLL/HCPB first wall and side caps. The used technologies are based on fusion and diffusion welding techniques taking into account specificities of the EUROFER-97 steel. Development of a standardized procedure complying with professional codes and standards (RCC-MRx), a preliminary fabrication/welding procedure specification (pF/WPS), is described as well as a fabrication and characterization of feasibility mock-ups (FMU) aimed at assessing the suitability of a fabrication process for fulfilling the design and fabrication specifications. Also, fabrication procedures for the TBM box assembly are presently under development through collaboration between European Fusion Laboratories and Industry for the establishment of an optimized assembly sequence/scenario and development of standardized welding procedure specifications. Selection of optimized assembly scenario takes into accounts not only the design requirements and fabrication possibilities/constraints but also maximum accessibility to the welds for sound non-destructive examination in compliance with welds classification. A future approach towards qualification of the developed fabrication technologies and procedures, through a number of medium to full-size qualification mock-ups according to European standards, is outlined before construction of the first TBMs.

  3. Golli Myelin Basic Proteins Modulate Voltage-Operated Ca(++) Influx and Development in Cortical and Hippocampal Neurons.

    Science.gov (United States)

    Vt, Cheli; DA, Santiago González; V, Spreuer; V, Handley; At, Campagnoni; Pm, Paez

    2016-10-01

    The golli proteins, products of the myelin basic protein gene, are widely expressed in oligodendrocyte progenitor cells and neurons during the postnatal development of the brain. While golli appears to be important for oligodendrocyte migration and differentiation, its function in neuronal development is completely unknown. We have found that golli proteins function as new and novel modulators of voltage-operated Ca(++) channels (VOCCs) in neurons. In vitro, golli knock-out (KO) neurons exhibit decreased Ca(++) influx after plasma membrane depolarization and a substantial maturational delay. Increased expression of golli proteins enhances L-type Ca(++) entry and processes outgrowth in cortical neurons, and pharmacological activation of L-type Ca(++) channels stimulates maturation and prevents cell death in golli-KO neurons. In situ, Ca(++) influx mediated by L-type VOCCs was significantly decreased in cortical and hippocampal neurons of the golli-KO brain. These Ca(++) alterations affect cortical and hippocampal development and the proliferation and survival of neural progenitor cells during the postnatal development of the golli-KO brain. The CA1/3 sections and the dentate gyrus of the hippocampus were reduced in the golli-KO mice as well as the density of dendrites in the somatosensory cortex. Furthermore, the golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety. Because of the expression of the golli proteins within neurons in learning and memory centers of the brain, this work has profound implication in neurodegenerative diseases and neurological disorders.

  4. Development and pilot testing of an online module for ethics education based on the Nigerian National Code for Health Research Ethics

    Science.gov (United States)

    2013-01-01

    Background The formulation and implementation of national ethical regulations to protect research participants is fundamental to ethical conduct of research. Ethics education and capacity are inadequate in developing African countries. This study was designed to develop a module for online training in research ethics based on the Nigerian National Code of Health Research Ethics and assess its ease of use and reliability among biomedical researchers in Nigeria. Methodology This was a three-phased evaluation study. Phase one involved development of an online training module based on the Nigerian Code of Health Research Ethics (NCHRE) and uploading it to the Collaborative Institutional Training Initiative (CITI) website while the second phase entailed the evaluation of the module for comprehensibility, readability and ease of use by 45 Nigerian biomedical researchers. The third phase involved modification and re-evaluation of the module by 30 Nigerian biomedical researchers and determination of test-retest reliability of the module using Cronbach’s alpha. Results The online module was easily accessible and comprehensible to 95% of study participants. There were significant differences in the pretest and posttest scores of study participants during the evaluation of the online module (p = 0.001) with correlation coefficients of 0.9 and 0.8 for the pretest and posttest scores respectively. The module also demonstrated excellent test-retest reliability and internal consistency as shown by Cronbach’s alpha coefficients of 0.92 and 0.84 for the pretest and posttest respectively. Conclusion The module based on the Nigerian Code was developed, tested and made available online as a valuable tool for training in cultural and societal relevant ethical principles to orient national and international biomedical researchers working in Nigeria. It would complement other general research ethics and Good Clinical Practice modules. Participants suggested that awareness of the

  5. Host modulation by a parasite: how Leishmania infantum modifies the intestinal environment of Lutzomyia longipalpis to favor its development.

    Science.gov (United States)

    Santos, Vania Cristina; Vale, Vladimir Fazito; Silva, Sydnei Magno; Nascimento, Alexandre Alves Sousa; Saab, Natalia Alvim Araujo; Soares, Rodrigo Pedro Pinto; Michalick, Marilene Suzan Marques; Araujo, Ricardo Nascimento; Pereira, Marcos Horacio; Fujiwara, Ricardo Toshio; Gontijo, Nelder Figueiredo

    2014-01-01

    Some reports have described the interference of Leishmania on sand flies physiology, and such behavior most likely evolved to favor the development and transmission of the parasite. Most of these studies showed that Leishmania could modulate the level of proteases in the midgut after an infective blood meal, and decreased proteolytic activity is indeed beneficial for the development of promastigotes in the gut of sand flies. In the present study, we performed a detailed investigation of the intestinal pH in Lutzomyia longipalpis females naturally infected with Leishmania infantum and investigated the production of trypsin by these insects using different approaches. Our results allowed us to propose a mechanism by which these parasites interfere with the physiology of L. longipalpis to decrease the production of proteolytic enzymes. According to our hypothesis L. infantum promastigotes indirectly interfere with the production of trypsin by modulating the mechanism that controls the intestinal pH via the action of a yet non-identified substance released by promastigote forms inside the midgut. This substance is not an acid, whose action would be restrict on to release H+ to the medium, but is a substance that is able to interfere with midgut physiology through a mechanism involving pH control. According to our hypothesis, as the pH decreases, the proteolytic enzymes efficiency is also reduced, leading to a decline in the supply of amino acids to the enterocytes: this decline reduces the stimulus for protease production because it is regulated by the supply of amino acids, thus leading to a delay in digestion.

  6. CLM4-BeTR, a generic biogeochemical transport and reaction module for CLM4: model development, evaluation, and application

    Directory of Open Access Journals (Sweden)

    J. Tang

    2012-09-01

    Full Text Available To improve regional and global biogeochemistry modeling and climate predictability, we have developed a generic reactive transport module for the land model CLM4 (called CLM4-BeTR (Biogeochemical Transport and Reactions. CLM4-BeTR represents the transport, interactions, and biotic and abiotic transformations of an arbitrary number of tracers (aka chemical species in an arbitrary number of phases (e.g. dissolved, gaseous, sorbed, aggregate. An operator splitting approach was employed and consistent boundary conditions were derived for each modeled sub-process. Tracer fluxes, associated with hydrological processes such as surface run-on and run-off, belowground drainage, and ice to liquid conversion were also computed consistently with the bulk water fluxes calculated by the soil physics module in CLM4. The transport code was evaluated and found be in good agreement with several analytical test cases. The model was then applied at the Harvard Forest site with a representation of depth-dependent belowground biogeochemistry. The results indicated that, at this site, (1 CLM4-BeTR was able to simulate soil-surface CO2 effluxes and soil CO2 profiles accurately; (2 the transient surface CO2 effluxes calculated based on the tracer transport mechanism were in general not equal to the belowground CO2 production rates and that their differences varied according to the seasonal cycle of soil physics and biogeochemistry; (3 losses of CO2 through processes other than surface gas efflux were less than 1% of the overall soil respiration; and (4 the contributions of root respiration and heterotrophic respiration have distinct temporal signals in surface CO2 effluxes and soil CO2 concentrations. The development of CLM4-BeTR will allow detailed comparisons between ecosystem observations and predictions and insights to the modeling of terrestrial biogeochemistry.

  7. Host modulation by a parasite: how Leishmania infantum modifies the intestinal environment of Lutzomyia longipalpis to favor its development.

    Directory of Open Access Journals (Sweden)

    Vania Cristina Santos

    Full Text Available Some reports have described the interference of Leishmania on sand flies physiology, and such behavior most likely evolved to favor the development and transmission of the parasite. Most of these studies showed that Leishmania could modulate the level of proteases in the midgut after an infective blood meal, and decreased proteolytic activity is indeed beneficial for the development of promastigotes in the gut of sand flies. In the present study, we performed a detailed investigation of the intestinal pH in Lutzomyia longipalpis females naturally infected with Leishmania infantum and investigated the production of trypsin by these insects using different approaches. Our results allowed us to propose a mechanism by which these parasites interfere with the physiology of L. longipalpis to decrease the production of proteolytic enzymes. According to our hypothesis L. infantum promastigotes indirectly interfere with the production of trypsin by modulating the mechanism that controls the intestinal pH via the action of a yet non-identified substance released by promastigote forms inside the midgut. This substance is not an acid, whose action would be restrict on to release H+ to the medium, but is a substance that is able to interfere with midgut physiology through a mechanism involving pH control. According to our hypothesis, as the pH decreases, the proteolytic enzymes efficiency is also reduced, leading to a decline in the supply of amino acids to the enterocytes: this decline reduces the stimulus for protease production because it is regulated by the supply of amino acids, thus leading to a delay in digestion.

  8. Energy technology development: GM prototype epoxy die facility module number 6011 - final report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D.A.; Mizzi, T.A. [General Motors of Canada Ltd., Toronto, ON (Canada)

    1993-01-01

    The development and testing of an innovative epoxy die prototype system for the production of automotive parts, was described. General Motors has developed a process which provides an economical way to stamp metal car parts in low volume. Until now, all prototype stamping dies were made with soft metal tooling. This new epoxy die system could save considerable lead-time, cost, and energy and could result in quality improvements in the production of prototype stampings. The technology could be used for low volume production vehicles such as for the new GM electric vehicle. The epoxy die process of GMR 233A as the die material and the process of plasma ion implantation, treating one-half of the die surface for comparison with the untreated half, was described. Several tables indicating potential energy savings are included. tabs., figs.

  9. Relatively Endocoherent Modules

    Institute of Scientific and Technical Information of China (English)

    Lixin Mao

    2007-01-01

    Let MR be a right R-module over a ring R with S= End(MR)We study the coherence of the left S-module sM relative to a torsion theory for the category of right R-modules.Various results are developed, many extending known results.

  10. Neonatal exposure to pneumococcal phosphorylcholine modulates the development of house dust mite allergy during adult life.

    Science.gov (United States)

    Patel, Preeyam S; Kearney, John F

    2015-06-15

    Currently, ∼20% of the global population suffers from an allergic disorder. Allergies and asthma occur at higher rates in developed and industrialized countries. It is clear that many human atopic diseases are initiated neonatally and herald more severe IgE-mediated disorders, including allergic asthma, which is driven by the priming of Th2 effector T cells. The hygiene hypothesis attempts to link the increased excessively sanitary conditions early in life to a default Th2 response and increasing allergic phenomena. Despite the substantial involvement of IgE Abs in such conditions, little attention has been paid to the effects of early microbial exposure on the B cell repertoire prior to the initiation of these diseases. In this study, we use Ab-binding assays to demonstrate that Streptococcus pneumoniae and house dust mite (HDM) bear similar phosphorylcholine (PC) epitopes. Neonatal C57BL/6 mice immunized with a PC-bearing pneumococcal vaccine expressed increased frequencies of PC-specific B cells in the lungs following sensitizing exposure to HDM as adults. Anti-PC IgM Abs in the lung decreased the interaction of HDM with pulmonary APCs and were affiliated with lowered allergy-associated cell infiltration into the lung, IgE production, development of airway hyperresponsiveness, and Th2 T cell priming. Thus, exposure of neonatal mice to PC-bearing pneumococci significantly reduced the development of HDM-induced allergic disease during adult life. Our findings demonstrate that B cells generated against conserved epitopes expressed by bacteria, encountered early in life, are also protective against the development of allergic disease during adult life. Copyright © 2015 by The American Association of Immunologists, Inc.

  11. Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation

    Science.gov (United States)

    Morioka, Yuka; Nam, Jin-Min; Ohashi, Takashi

    2017-01-01

    Nik-related kinase (Nrk) is a Ser/Thr kinase and was initially discovered as a molecule that was predominantly detected in skeletal muscles during development. A recent study using Nrk-null mice suggested the importance of Nrk in proper placental development; however, the molecular mechanism remains unknown. In this study, we demonstrated that differentiated trophoblasts from murine embryonic stem cells (ESCs) endogenously expressed Nrk and that Nrk disruption led to the enhanced proliferation of differentiated trophoblasts. This phenomenon may reflect the overproliferation of trophoblasts that has been reported in enlarged placentas of Nrk-null mice. Furthermore, we demonstrated that AKT phosphorylation at Ser473 was upregulated in Nrk-null trophoblasts and that inhibition of AKT phosphorylation cancelled the enhanced proliferation observed in differentiated Nrk-null trophoblasts. These results indicated that the upregulation of AKT phosphorylation was the possible cause of enhanced proliferation observed in Nrk-null trophoblasts. The upregulation of AKT phosphorylation was also confirmed in enlarged Nrk-null placentas in vivo, suggesting that proper regulation of AKT by Nrk was important for normal placental development. In addition, our detailed analysis on phosphorylation status of AKT isoforms in newly established trophoblast stem cells (TSCs) revealed that different levels of upregulation of AKT phosphorylation were occurred in Nrk-null TSCs depending on AKT isoforms. These results further support the importance of Nrk in proper development of trophoblast lineage cells and indicate the possible application of TSCs for the analysis of differently regulated activation mechanisms of AKT isoforms. PMID:28152035

  12. RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans

    OpenAIRE

    Rui Xiao; Lei Chun; Elizabeth A. Ronan; David I. Friedman; Jianfeng Liu; X.Z. Shawn Xu

    2015-01-01

    Diet affects nearly every aspect of animal life, such as development, metabolism, behavior and aging, both directly by supplying nutrients and indirectly through gut microbiota. C. elegans feeds on bacteria, and like other animals, different bacterial diets induce distinct dietary responses in the worm. However, the lack of certain critical tools hampers the use of worms as a model for dietary signaling. Here, we genetically-engineered the bacterial strain OP50, the standard...

  13. Aquatic Contaminant and Mercury Simulation Modules Developed for Hydrologic and Hydraulic Models

    Science.gov (United States)

    2016-07-01

    environmental challenges. ERDC develops innovative solutions in civil and military engineering, geospatial sciences, water resources , and environmental...in high-sulfate estuarine sediments is far lower than the rate in low-sulfate freshwater sediments. In fresh water sediments, methylation has been...calibration parameters in real world applications. Similar to CSM, HgSM’s parameters for the water column and sediment layer can be specified as either

  14. Development of motor maps in rats and their modulation by experience.

    Science.gov (United States)

    Young, Nicole A; Vuong, Jennifer; Teskey, G Campbell

    2012-09-01

    While a substantial literature demonstrates the effect of differential experience on development of mammalian sensory cortices and plasticity of adult motor cortex, characterization of differential experience on the functional development of motor cortex is meager. We first determined when forelimb movement representations (motor maps) could be detected in rats during postnatal development and then whether their motor map expression could be altered with rearing in an enriched environment consisting of group housing and novel toys or skilled learning by training on the single pellet reaching task. All offspring had high-resolution intracortical microstimulation (ICMS)-derived motor maps using methodologies previously optimized for the adult rat. First, cortical GABA-mediated inhibition was depressed by bicuculline infusion directly into layer V of motor cortex and ICMS-responsive points were first reliably detected on postnatal day (PND) 13. Without relying on bicuculline disinhibition of cortex, motor maps emerged on PND 35 and then increased in size until PND 60 and had progressively lower movement thresholds. Second, environmental enrichment did not affect initial detection of responsive points and motor maps in non-bicuculline-treated pups on PND 35. However, motor maps were larger on PND 45 in enriched rat pups relative to pups in the standard housing condition. Rats in both conditions had similar map sizes on PNDs 60, 75, and 90. Third, reach training in rat pups resulted in an internal reorganization of the map in the hemisphere contralateral, but not ipsilateral, to the trained forelimb. The map reorganization was expressed as proportionately more distal (digit and wrist) representations on PND 45. Our data indicate that both environmental enrichment and skilled reach training experience can differentially modify expression of motor maps during development.

  15. Gender modulates the development of theta event related oscillations in adolescents and young adults.

    Science.gov (United States)

    Chorlian, David B; Rangaswamy, Madhavi; Manz, Niklas; Kamarajan, Chella; Pandey, Ashwini K; Edenberg, Howard; Kuperman, Samuel; Porjesz, Bernice

    2015-10-01

    The developmental trajectories of theta band (4-7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. These tasks call upon attentional and working memory resources. Large differences in developmental rates between males and females were found; scalp location and task modality (visual or auditory) differences within males and females were small compared to gender differences. Trajectories of interregional and intermodal correlations between ERO power values exhibited increases with age in both genders, but showed a divergence in development between auditory and visual systems during ages 16 to 21. These results are consistent with previous electrophysiological and imaging studies and provide additional temporal detail about the development of neurophysiological indices of cognitive activity. Since measures of the P3 response has been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions.

  16. 17 beta-estradiol modulates GABAergic synaptic transmission and tonic currents during development in vitro.

    Science.gov (United States)

    Pytel, Maria; Wójtowicz, Tomasz; Mercik, Katarzyna; Sarto-Jackson, Isabella; Sieghart, Werner; Ikonomidou, Chrysanthy; Mozrzymas, Jerzy W

    2007-05-01

    Estrogens exert a variety of modulatory effects on the structure and function of the nervous system. In particular, 17 beta-estradiol was found to affect GABAergic inhibition in adult animals but its action on GABAergic currents during development has not been elucidated. In the present study, we investigated the effect of 17 beta-estradiol on hippocampal neurons developing in vitro. In this model, mIPSC kinetics showed acceleration with age along with increased alpha1 subunit expression, similarly as in vivo. Long-term treatment with 17 beta-estradiol increased mIPSC amplitudes in neurons cultured for 6-8 and 9-11DIV and prolonged the mIPSC decaying phase only in the 9-11DIV group. The time needed for the onset of 17 beta-estradiol effect on mIPSC amplitude was approximately 48 h. In the period of 9-11DIV, treatment with 17 beta-estradiol strongly reduced the tonic conductance activated by low GABA concentrations. The effects of 17 beta-estradiol on mIPSCs and tonic conductance were not correlated with any change in expression of considered GABAAR subunits (alpha1-3, alpha5-6, gamma2) while alpha4 and delta subunits were at the detection limit. In conclusion, we provide evidence that 17 beta-estradiol differentially affects the phasic and tonic components of GABAergic currents in neurons developing in vitro.

  17. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation.

    Science.gov (United States)

    Langdon, Amy; Crook, Nathan; Dantas, Gautam

    2016-04-13

    The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal. Human-associated microbes perform an array of important functions, and we are now just beginning to understand the ways in which antibiotics have reshaped their ecology and the functional consequences of these changes. Mounting evidence shows that antibiotics influence the function of the immune system, our ability to resist infection, and our capacity for processing food. Therefore, it is now more important than ever to revisit how we use antibiotics. This review summarizes current research on the short-term and long-term consequences of antibiotic use on the human microbiome, from early life to adulthood, and its effect on diseases such as malnutrition, obesity, diabetes, and Clostridium difficile infection. Motivated by the consequences of inappropriate antibiotic use, we explore recent progress in the development of antivirulence approaches for resisting infection while minimizing resistance to therapy. We close the article by discussing probiotics and fecal microbiota transplants, which promise to restore the microbiota after damage of the microbiome. Together, the results of studies in this field emphasize the importance of developing a mechanistic understanding of gut ecology to enable the development of new therapeutic strategies and to rationally limit the use of antibiotic compounds.

  18. Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development

    Science.gov (United States)

    Bhinder, Ganive; Allaire, Joannie M.; Garcia, Cyrielle; Lau, Jennifer T.; Chan, Justin M.; Ryz, Natasha R.; Bosman, Else S.; Graef, Franziska A.; Crowley, Shauna M.; Celiberto, Larissa S.; Berkmann, Julia C.; Dyer, Roger A.; Jacobson, Kevan; Surette, Michael G.; Innis, Sheila M.; Vallance, Bruce A.

    2017-01-01

    Breast milk has many beneficial properties and unusual characteristics including a unique fat component, termed milk fat globule membrane (MFGM). While breast milk yields important developmental benefits, there are situations where it is unavailable resulting in a need for formula feeding. Most formulas do not contain MFGM, but derive their lipids from vegetable sources, which differ greatly in size and composition. Here we tested the effects of MFGM supplementation on intestinal development and the microbiome as well as its potential to protect against Clostridium difficile induced colitis. The pup-in-a-cup model was used to deliver either control or MFGM supplemented formula to rats from 5 to 15 days of age; with mother’s milk (MM) reared animals used as controls. While CTL formula yielded significant deficits in intestinal development as compared to MM littermates, addition of MFGM to formula restored intestinal growth, Paneth and goblet cell numbers, and tight junction protein patterns to that of MM pups. Moreover, the gut microbiota of MFGM and MM pups displayed greater similarities than CTL, and proved protective against C. difficile toxin induced inflammation. Our study thus demonstrates that addition of MFGM to formula promotes development of the intestinal epithelium and microbiome and protects against inflammation. PMID:28349941

  19. The HSP, the QCN, and the Dragon: Developing inquiry-based QCN instructional modules in Taiwan

    Science.gov (United States)

    Chen, K. H.; Liang, W.; Chang, C.; Yen, E.; Lin, C.; Lin, G.

    2012-12-01

    High Scope Program (HSP) is a long-term project funded by NSC in Taiwan since 2006. It is designed to elevate the quality of science education by means of incorporating emerging science and technology into the traditional curricula in senior high schools. Quake-Catcher Network (QCN), a distributed computing project initiated by Stanford University and UC Riverside, encourages the volunteers to install the low-cost, novel sensors at home and school to build a seismic network. To meet both needs, we have developed a model curriculum that introduces QCN, earthquake science, and cloud computing into high school classrooms. Through professional development workshops, Taiwan cloud-based earthquake science learning platform, and QCN club on Facebook, we have worked closely with Lan-Yang Girl's Senior High School teachers' team to design workable teaching plans through a practical operation of seismic monitoring at home or school. However, some obstacles to learning appear including QCN installation/maintain problems, high self-noise of the sensor, difficulty of introducing earthquake sciences for high school teachers. The challenges of QCN outreach in Taiwan bring out our future plans: (1) development of easy, frequently updated, physics-based QCN-experiments for high school teachers, and (2) design of an interactive learning platform with social networking function for students.

  20. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia.

    Directory of Open Access Journals (Sweden)

    Yijin Tao

    Full Text Available The development of myopia is associated with decreased ocular scleral collagen synthesis in humans and animal models. Collagen synthesis is, in part, under the influence of cyclic adenosine monophosphate (cAMP. We investigated the associations between cAMP, myopia development in guinea pigs, and collagen synthesis by human scleral fibroblasts (HSFs. Form-deprived myopia (FDM was induced by unilateral masking of guinea pig eyes. Scleral cAMP levels increased selectively in the FDM eyes and returned to normal levels after unmasking and recovery. Unilateral subconjunctival treatment with the adenylyl cyclase (AC activator forskolin resulted in a myopic shift accompanied by reduced collagen mRNA levels, but it did not affect retinal electroretinograms. The AC inhibitor SQ22536 attenuated the progression of FDM. Moreover, forskolin inhibited collagen mRNA levels and collagen secretion by HSFs. The inhibition was reversed by SQ22536. These results demonstrate a critical role of cAMP in control of myopia development. Selective regulation of cAMP to control scleral collagen synthesis may be a novel therapeutic strategy for preventing and treating myopia.