WorldWideScience

Sample records for twelve-step recovery model

  1. Alcoholics Anonymous and twelve-step recovery: a model based on social and cognitive neuroscience.

    Science.gov (United States)

    Galanter, Marc

    2014-01-01

    In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change. Literature review and hypothesis development. Pertinent aspects of the neural impact of drugs of abuse are summarized. After this, research regarding specific brain sites, elucidated primarily by imaging techniques, is reviewed relative to the following: Mirroring and mentalizing are described in relation to experimentally modeled studies on empathy and mutuality, which may parallel the experiences of social interaction and influence on AA members. Integration and retrieval of memories acquired in a setting like AA are described, and are related to studies on storytelling, models of self-schema development, and value formation. A model for ascription to a Higher Power is presented. The phenomena associated with AA reflect greater complexity than the empirical studies on which this article is based, and certainly require further elucidation. Despite this substantial limitation in currently available findings, there is heuristic value in considering the relationship between the brain-based and clinical phenomena described here. There are opportunities for the study of neuroscientific correlates of Twelve-Step-based recovery, and these can potentially enhance our understanding of related clinical phenomena. © American Academy of Addiction Psychiatry.

  2. Alcoholics anonymous and other twelve-step programs in recovery.

    Science.gov (United States)

    Detar, D Todd

    2011-03-01

    Recovery is a new way of life for many patients; a life without substances to alter their moods but with a major change improving the physical, psychological, and emotional stability with improved overall health outcomes. The Twelve Steps of the Alcoholics Anonymous (AA) are the foundation of the AA, describing both the necessary actions and the spiritual basis for the recovery program of the AA. The Twelve Steps of the AA provide a structure for which a patient with alcoholism may turn for an answer to their problem of alcohol use, abuse, or dependence. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. The Role of Twelve-Step-Related Spirituality in Addiction Recovery.

    Science.gov (United States)

    Dermatis, Helen; Galanter, Marc

    2016-04-01

    This paper reviews empirical studies conducted on the role of spirituality and religiosity (S/R) characteristics in 12-step recovery among program members followed up after substance abuse treatment and those assessed independent of formal treatment. Aspects of spiritual functioning that change in relation to program participation and those S/R characteristics that were found to mediate the association between program involvement and drinking-related outcomes are discussed. In addition, a review is provided of 12-step program studies investigating S/R-related predictors of clinical outcomes relevant to risk of relapse among members in long-term recovery. To further examine the role of S/R characteristics in recovery, a study was conducted on long-term AA members to assess the relationship of S/R characteristics and AA program involvement to craving for alcohol and emotional distress after controlling for relevant demographic variables. Feeling God's presence daily, believing in a higher power as a universal spirit, and serving as an AA sponsor were all predictive of positive outcomes.

  4. The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery.

    Science.gov (United States)

    Blum, Kenneth; Thompson, Benjamin; Demotrovics, Zsolt; Femino, John; Giordano, John; Oscar-Berman, Marlene; Teitelbaum, Scott; Smith, David E; Roy, A Kennison; Agan, Gozde; Fratantonio, James; Badgaiyan, Rajendra D; Gold, Mark S

    There are some who suggest that alcoholism and drug abuse are not diseases at all and that they are not consequences of a brain disorder as espoused recently by the American Society of Addiction Medicine (ASAM). Some would argue that addicts can quit on their own and moderate their alcohol and drug intake. When they present to a treatment program or enter the 12 Step Program & Fellowship, many addicts finally achieve complete abstinence. However, when controlled drinking fails, there may be successful alternatives that fit particular groups of individuals. In this expert opinion, we attempt to identify personal differences in recovery, by clarifying the molecular neurobiological basis of each step of the 12 Step Program. We explore the impact that the molecular neurobiological basis of the 12 steps can have on Reward Deficiency Syndrome (RDS) despite addiction risk gene polymorphisms. This exploration has already been accomplished in part by Blum and others in a 2013 Springer Neuroscience Brief. The purpose of this expert opinion is to briefly, outline the molecular neurobiological and genetic links, especially as they relate to the role of epigenetic changes that are possible in individuals who regularly attend AA meetings. It begs the question as to whether "12 steps programs and fellowship" does induce neuroplasticity and continued dopamine D2 receptor proliferation despite carrying hypodopaminergic type polymorphisms such as DRD2 A1 allele. "Like-minded" doctors of ASAM are cognizant that patients in treatment without the "psycho-social-spiritual trio," may not be obtaining the important benefits afforded by adopting 12-step doctrines. Are we better off with coupling medical assisted treatment (MAT) that favors combining dopamine agonist modalities (DAM) as possible histone-deacetylase activators with the 12 steps followed by a program that embraces either one or the other? While there are many unanswered questions, at least we have reached a time when "science

  5. The impact of alcoholics anonymous on other substance abuse-related twelve-step programs.

    Science.gov (United States)

    Laudet, Alexandre B

    2008-01-01

    This chapter explores the influence of the AA model on self-help fellowships addressing problems of drug dependence. Fellowships that have adapted the twelve-step recovery model to other substances of abuse are reviewed; next similarities and differences between AA and drug-recovery twelve-step organizations are examined; finally, we present empirical findings on patterns of attendance and perceptions of AA and Narcotics Anonymous (NA) among polydrug-dependent populations, many of whom are cross-addicted to alcohol. Future directions in twelve-step research are noted in closing.

  6. Synergy between Seeking Safety and Twelve-Step Affiliation on Substance Use Outcomes for Women

    Science.gov (United States)

    Morgan-Lopez, Antonio A.; Saavedra, Lissette M.; Hien, Denise A.; Campbell, Aimee N.; Wu, Elwin; Ruglass, Lesia

    2014-01-01

    Objective The Recovery Management paradigm provides a conceptual framework for the examination of joint impact of a focal treatment and post-treatment service utilization on substance abuse treatment outcomes. We test this framework by examining the interactive effects of a treatment for comorbid PTSD and substance use, Seeking Safety, and post-treatment Twelve-Step Affiliation (TSA) on alcohol and cocaine use. Method Data from 353 women in a six-site, randomized controlled effectiveness trial within the NIDA Clinical Trials Network were analyzed under latent class pattern mixture modeling. LCPMM was used to model variation in Seeking Safety by TSA interaction effects on alcohol and cocaine use. Results Significant reductions in alcohol use among women in Seeking Safety (compared to Health Education) were observed; women in the Seeking Safety condition who followed up with TSA had the greatest reductions over time in alcohol use. Reductions in cocaine use over time were also observed but did not differ between treatment conditions nor were there interactions with post-treatment TSA. Conclusions Findings advance understanding of the complexities for treatment and continuing recovery processes for women with PTSD and SUDs, and further support the chronic disease model of addiction. PMID:23558158

  7. The Impact of Alcoholics Anonymous on other substance abuse related Twelve Step programs

    Science.gov (United States)

    Laudet, Alexandre B.

    2008-01-01

    This chapter explores the influence of the AA model on self-help fellowships addressing problems of drug dependence. Fellowships that have adapted the 12-step recovery model to other substances of abuse are reviewed; next similarities and differences between AA and drug-recovery 12-step organizations are examined; finally, we present empirical findings on patterns of attendance and perceptions of AA and Narcotics Anonymous (NA) among polydrug dependent populations, many of whom are cross-addicted to alcohol. Future directions in 12-step research are noted in closing. PMID:19115764

  8. Recovery from schizophrenia and the recovery model.

    Science.gov (United States)

    Warner, Richard

    2009-07-01

    The recovery model refers to subjective experiences of optimism, empowerment and interpersonal support, and to a focus on collaborative treatment approaches, finding productive roles for user/consumers, peer support and reducing stigma. The model is influencing service development around the world. This review will assess whether optimism about outcome from serious mental illness and other tenets of the recovery model are borne out by recent research. Remission of symptoms has been precisely defined, but the definition of 'recovery' is a more diffuse concept that includes such factors as being productive and functioning independently. Recent research and a large, earlier body of data suggest that optimism about outcome from schizophrenia is justified. A substantial proportion of people with the illness will recover completely and many more will regain good social functioning. Outcome is better for people in the developing world. Mortality for people with schizophrenia is increasing but is lower in the developing world. Working appears to help people recover from schizophrenia, and recent advances in vocational rehabilitation have been shown to be effective in countries with differing economies and labor markets. A growing body of research supports the concept that empowerment is an important component of the recovery process. Key tenets of the recovery model - optimism about recovery from schizophrenia, the importance of access to employment and the value of empowerment of user/consumers in the recovery process - are supported by the scientific research. Attempts to reduce the internalized stigma of mental illness should enhance the recovery process.

  9. Robust Disaster Recovery System Model

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Highly security-critical system should possess features of continuous service. We present a new Robust Disaster Recovery System Model (RDRSM). Through strengthening the ability of safe communications, RDRSM guarantees the secure and reliable command on disaster recovery. Its self-supervision capability can monitor the integrality and security of disaster recovery system itself. By 2D and 3D real-time visible platform provided by GIS, GPS and RS, the model makes the using, management and maintenance of disaster recovery system easier. RDRSM possesses predominant features of security, robustness and controllability. And it can be applied to highly security-critical environments such as E-government and bank. Conducted by RDRSM, an important E-government disaster recovery system has been constructed successfully. The feasibility of this model is verified by practice. We especially emphasize the significance of some components of the model, such as risk assessment, disaster recovery planning, system supervision and robust communication support.

  10. Mechanisms of action in integrated cognitive-behavioral treatment versus twelve-step facilitation for substance-dependent adults with comorbid major depression.

    Science.gov (United States)

    Glasner-Edwards, Suzette; Tate, Susan R; McQuaid, John R; Cummins, Kevin; Granholm, Eric; Brown, Sandra A

    2007-09-01

    In a population of veterans with co-occurring substance use disorders and concomitant major depressive disorder, the current study compared mechanisms of change and therapeutic effects relevant to both disorders between integrated, dual disorder-specific cognitive behavioral therapy (ICBT) and twelve-step facilitation (TSF). Veterans (N = 148) were given standard pharmacotherapy for depression and were randomly assigned to receive 24 weeks of either TSF or ICBT. Process measures were selected to quantify (1) changes in self-efficacy in ICBT, (2) changes in ability to terminate negative affect in ICBT, (3) twelve-step affiliation (TSA) in TSF, and (4) changes in social support in both conditions. Measures of depression and substance use were administered to all participants before treatment, during treatment, and at the end of treatment. Self-efficacy increased among both TSF and ICBT participants during treatment, whereas self-reported ability to regulate negative affect did not change. Consistent with predictions, TSF participants increased community TSA during treatment, whereas those receiving ICBT reduced TSA. Changes in self-efficacy and TSA were associated with improvement in substance use outcomes at the end of treatment. Hypothesized changes in social support were not supported. Both ICBT and TSF produce improvements in self-efficacy, and these changes are related to substance use outcomes for depressed substance abusers. In TSF, intervention-specific changes in TSA occur during the course of treatment and are related to substance use outcomes.

  11. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial

    Science.gov (United States)

    Carroll, Kathleen M.; Nich, Charla; Shi, Julia M.; Eagan, Dorothy; Ball, Samuel A.

    2012-01-01

    Background Cocaine use remains a major problem within methadone maintenance programs. Disulfiram’s efficacy in reducing cocaine use has been demonstrated in several trials, but its relative efficacy among individuals who use versus abstain from alcohol remains unclear Treatment approaches which seek to enhance substance users’ involvement in self-help activities (Twelve Step Facilitation, TSF) have been associated with better outcomes among alcohol and cocaine users, but have rarely been evaluated among methadone-maintained cocaine-opioid users. Methods We conducted a randomized, placebo controlled, double blind (for medication condition), factorial (2×2) trial with 4 treatment conditions: Disulfiram plus TSF, disulfiram plus standard counseling only, placebo plus TSF, and placebo plus standard counseling in the context of a community-based methadone maintenance program. Participants (N=112) received either disulfiram (250 mg/d) or placebo in conjunction with daily methadone maintenance. Results Assignment to TSF was associated with less cocaine use throughout treatment and a higher number of cocaine-negative urines. While there were no significant main effects of disulfiram versus placebo, individuals without an alcohol use disorder demonstrated greater reductions in cocaine use over time when assigned to disulfiram. Conclusions TSF appears feasible in this methadone maintenance program and was associated with modest reductions in cocaine use, an often intractable problem in this setting. Support for the efficacy of disulfiram was weaker, as it appeared effective only for those without a current alcohol use disorder for this sample. PMID:22695473

  12. Modeling premature brain injury and recovery

    Science.gov (United States)

    Scafidi, Joey; Fagel, Devon M.; Ment, Laura R.; Vaccarino, Flora M.

    2009-01-01

    Premature birth is a growing and significant public health problem because of the large number of infants that survive with neurodevelopmental sequelae from brain injury. Recent advances in neuroimaging have shown that although some neuroanatomical structures are altered, others improve over time. This review outlines recent insights into brain structure and function in these preterm infants at school age and relevant animal models. These animal models have provided scientists with an opportunity to explore in depth the molecular and cellular mechanisms of injury as well as the potential of the brain for recovery. The endogenous potential that the brain has for neurogenesis and gliogenesis, and how environment contributes to recovery, are also outlined. These preclinical models will provide important insights into the genetic and epigenetic mechanisms responsible for variable degrees of injury and recovery, permitting the exploration of targeted therapies to facilitate recovery in the developing preterm brain. PMID:19482072

  13. What is recovery? A conceptual model and explication.

    Science.gov (United States)

    Jacobson, N; Greenley, D

    2001-04-01

    This paper describes a conceptual model of recovery from mental illness developed to aid the state of Wisconsin in moving toward its goal of developing a "recovery-oriented" mental health system. In the model, recovery refers to both internal conditions experienced by persons who describe themselves as being in recovery--hope, healing, empowerment, and connection--and external conditions that facilitate recovery--implementation of the principle of human rights, a positive culture of healing, and recovery-oriented services. The aim of the model is to link the abstract concepts that define recovery with specific strategies that systems, agencies, and individuals can use to facilitate it.

  14. Recovery boiler model; Soodakattilan kehitystyoe III

    Energy Technology Data Exchange (ETDEWEB)

    Janka, K.; Ylitalo, M.; Sundstroem, K.; Helke, R.; Heinola, M. [Kvaerner Pulping Oy, Tampere (Finland)

    1997-10-01

    The recovery boiler model was further tested and developed. At this moment the model includes submodels for: droplet drying, pyrolysis, char burning, gas burning and for droplet trajectory. During 1996 the formation of CH{sub 4} during pyrolysis and release of sulfur was included to the model. Further the formation of NO from fuel nitrogen and formation of thermal- NO were included to the model using Arrhenius type reaction rate equations. The calculated results are realistic and the model is used as a tool to find out methods to increase the efficiency and availability and decrease the emissions. Analysing the results of the earlier field study of 8 boilers showed that the furnace heat load, fuming rate, find the black liquor composition have influence on the enrichment of the potassium to the fly ash. (orig.)

  15. Twelve steps to evaluating interprofessional education

    Directory of Open Access Journals (Sweden)

    Scott Reeves, PhD

    2016-12-01

    Full Text Available تضع هذه الورقة خطة؛ خطوة بخطوة لمساعدة القراء على تصميم وتطبيق وتوزيع تقاييم التعليم المتداخل بين التخصصات نقدم الإثنتي عشرة خطوة التالية التي تعتبر أساسية لهذه العملية: صياغة أسئلة التقييم, والاتفاق على نهج التقييم, واستخدام أطر للتقييم, والاعتماد على خبرات التقييم, ومراجعة الأدبيات, واختيار الأسلوب والتصميم, وتأمين الموافقة الأخلاقية, والوصول إلى البيانات, ومعالجة قضايا العمل الميداني, واستخدام أدوات التقييم, والنظر في الموارد, وخيارات التوزيع.

  16. Twelve Steps toward Revitalization for Teachers.

    Science.gov (United States)

    Newbrough, Art

    1983-01-01

    A dozen common sense ways to respond to and counter the teacher burnout syndrome are briefly discussed. Strategies include physical exercise, stress controls, recultivating special relationships, self-expressions, celebrations, enthusiasm maintenance, and professional support. The aticle is designed to help educators maintain a perspective on…

  17. A working model of stroke recovery from rehabilitation robotics practitioners

    Directory of Open Access Journals (Sweden)

    Krebs Hermano

    2009-02-01

    Full Text Available Abstract We reviewed some of our initial insights about the process of upper-limb behavioral recovery following stroke. Evidence to date indicates that intensity, task specificity, active engagement, and focusing training on motor coordination are key factors enabling efficacious recovery. On modeling, experience with over 400 stroke patients has suggested a working model of recovery similar to implicit motor learning. Ultimately, we plan to apply these insights in the development of customized training paradigms to enhance recovery.

  18. A working model of stroke recovery from rehabilitation robotics practitioners.

    Science.gov (United States)

    Krebs, Hermano Igo; Volpe, Bruce; Hogan, Neville

    2009-02-25

    We reviewed some of our initial insights about the process of upper-limb behavioral recovery following stroke. Evidence to date indicates that intensity, task specificity, active engagement, and focusing training on motor coordination are key factors enabling efficacious recovery. On modeling, experience with over 400 stroke patients has suggested a working model of recovery similar to implicit motor learning. Ultimately, we plan to apply these insights in the development of customized training paradigms to enhance recovery.

  19. Measuring Mental Health Recovery: An Application of Rasch Modeling to the Consumer Recovery Measure.

    Science.gov (United States)

    Lusczakoski, Kathryn Kd; Olmos-Gallo, P Antonio; Milnor, William; McKinney, Christopher J

    2016-01-01

    As the need for recovery-oriented outcomes increases, it is critical to understand how numeric recovery scores are developed. In the current article, the modern Rasch modeling techniques were applied to establish numeric scores of consumers' perceptions of recovery. A sample of 1,973 adult consumers at a community-based mental health center (57.5% male; average age of 47 years old) completed the 15-item Consumer Recovery Measure. A confirmatory factor analysis revealed the unidimensional nature of the Consumer Recovery Measure and provided construct validity evidence. The Rasch analysis displayed that the items produced acceptable model fit, reliability, and identified the difficulty of the items. The conclusion emphasizes the value of Rasch modeling regarding the measurement of recovery and its relevance to consumer-derived assessments in the clinical decision-making process.

  20. Hurricane Sandy, Disaster Preparedness, and the Recovery Model.

    Science.gov (United States)

    Pizzi, Michael A

    2015-01-01

    Hurricane Sandy was the second largest and costliest hurricane in U.S. history to affect multiple states and communities. This article describes the lived experiences of 24 occupational therapy students who lived through Hurricane Sandy using the Recovery Model to frame the research. Occupational therapy student narratives were collected and analyzed using qualitative methods and framed by the Recovery Model. Directed content and thematic analysis was performed using the 10 components of the Recovery Model. The 10 components of the Recovery Model were experienced by or had an impact on the occupational therapy students as they coped and recovered in the aftermath of the natural disaster. This study provides insight into the lived experiences and recovery perspectives of occupational therapy students who experienced Hurricane Sandy. Further research is indicated in applying the Recovery Model to people who survive disasters. Copyright © 2015 by the American Occupational Therapy Association, Inc.

  1. Two-year outcome of alcohol interventions in Swedish university halls of residence: a cluster randomized trial of a brief skills training program, twelve-step-influenced intervention, and controls.

    Science.gov (United States)

    Ståhlbrandt, Henriettae; Johnsson, Kent O; Berglund, Mats

    2007-03-01

    High-risk alcohol consumption among university students is well documented. Several types of intervention have proved to be effective in reducing alcohol consumption. This study examines the 2-year outcome of 2 different alcohol intervention programs at university halls of residence. Ninety-eight university halls of residence (with 556 students) were cluster randomized to 2 different intervention groups: a brief skills training program (BSTP) with interactive lectures and discussions, a twelve-step-influenced (TSI) program with didactic lectures by therapists trained in the 12-step approach, and a control group. All students completing the baseline assessment received personalized feedback by mail. Students responded to mailed follow-up questionnaires after 1, 2, and 3 years, including alcohol use disorders identification test (AUDIT; years 2 and 3), short index of problems (SIP), and estimated blood alcohol concentration (eBAC). All groups significantly reduced their AUDIT scores from baseline to the second year follow-up, with no significant differences between the groups. Seventy-seven percent of the students belonged to a population with high-risk consumption, using the AUDIT cut-off scores of 8 and 4 for men and women, respectively. Students with high-risk alcohol consumption showed significant differences in AUDIT score reduction in favor of the BSTP compared with controls, and had a tendency to show better results than the TSI intervention (p=0.06). Similar trends could be seen using SIP and eBAC. The TSI did not differ significantly from the control group within the group of students with high-risk alcohol consumption. This study suggests that a BSTP is effective as an intervention in students with high-risk alcohol consumption.

  2. A working model of stroke recovery from rehabilitation robotics practitioners

    OpenAIRE

    Krebs Hermano; Volpe Bruce; Hogan Neville

    2009-01-01

    Abstract We reviewed some of our initial insights about the process of upper-limb behavioral recovery following stroke. Evidence to date indicates that intensity, task specificity, active engagement, and focusing training on motor coordination are key factors enabling efficacious recovery. On modeling, experience with over 400 stroke patients has suggested a working model of recovery similar to implicit motor learning. Ultimately, we plan to apply these insights in the development of customiz...

  3. A model for recovery kinetics of aluminum after large strain

    DEFF Research Database (Denmark)

    Yu, Tianbo; Hansen, Niels

    2012-01-01

    A model is suggested to analyze recovery kinetics of heavily deformed aluminum. The model is based on the hardness of isothermal annealed samples before recrystallization takes place, and it can be extrapolated to longer annealing times to factor out the recrystallization component of the hardness...... for conditions where recovery and recrystallization overlap. The model is applied to the isothermal recovery at temperatures between 140 and 220°C of commercial purity aluminum deformed to true strain 5.5. EBSD measurements have been carried out to detect the onset of discontinuous recrystallization. Furthermore...

  4. Modeling, Instrumentation, Automation, and Optimization of Water Resource Recovery Facilities.

    Science.gov (United States)

    Sweeney, Michael W; Kabouris, John C

    2016-10-01

    A review of the literature published in 2015 on topics relating to water resource recovery facilities (WRRF) in the areas of modeling, automation, measurement and sensors and optimization of wastewater treatment (or water resource reclamation) is presented.

  5. Paralysis recovery in humans and model systems

    Science.gov (United States)

    Edgerton, V. Reggie; Roy, Roland R.

    2002-01-01

    Considerable evidence now demonstrates that extensive functional and anatomical reorganization following spinal cord injury occurs in centers of the brain that have some input into spinal motor pools. This is very encouraging, given the accumulating evidence that new connections formed across spinal lesions may not be initially functionally useful. The second area of advancement in the field of paralysis recovery is in the development of effective interventions to counter axonal growth inhibition. A third area of significant progress is the development of robotic devices to quantify the performance level of motor tasks following spinal cord injury and to 'teach' the spinal cord to step and stand. Advances are being made with robotic devices for mice, rats and humans.

  6. Recovery modeling of tangential flow systems.

    Science.gov (United States)

    Rao, Suma; Gefroh, Eva; Kaltenbrunner, Oliver

    2012-12-01

    The demand for increased formulation concentrations for protein therapeutics puts a significant strain on already existing tangential flow filtration (TFF) systems that were constructed with lower protein concentration targets as part of their design criteria. TFF is commonly used to buffer exchange and concentrate the product to the appropriate drug substance concentration. Analyzing the ability of an existing TFF system to process under conditions outside its original design specifications can be challenging. In this analysis, we present a systematic approach to assess the operational limits of a TFF process with consideration of system performance parameters for changing process targets. In two new engineering diagrams, the recovery efficiency diagram and the operating space plot, all relevant operational constraints and parameters are related to allow rapid process fit evaluation. The engineering assessment of TFF systems presented in this article allows a rational review of system limitations during process fit evaluations of existing TFF systems. It also provides a rational basis for targeted system upgrades and setting system design specifications for the design of new systems if existing systems are found inadequate. Copyright © 2012 Wiley Periodicals, Inc.

  7. Modeling the recovery phase of extreme geomagnetic storms

    CERN Document Server

    Cid, C; Saiz, E; Cerrato, Y; Aguado, J; Guerrero, A

    2014-01-01

    The recovery phase of the largest storms ever recorded has been studied. These events provide an extraordinary opportunity for two goals: (1) to validate the hyperbolic model by Aguado et al. [2010] for the recovery phase after disturbances as severe as the Carrington event, or that related to the Hydro-Quebec blackout in March 1989, and (2) to check whether the linear relationship between the recovery time and the intensity of the storm still complies. Our results reveal the high accuracy of the hyperbolic decay function to reproduce the recovery phase of the magnetosphere after an extreme storm. Moreover, the characteristic time that takes the magnetosphere to recover depends in an exponential way on the intensity of the storm, as indicated by the relationship between the two parameters involved in the hyperbolic decay. This exponential function can be approached by a linear function when the severity of the storm diminishes.

  8. Computational neurorehabilitation: modeling plasticity and learning to predict recovery.

    Science.gov (United States)

    Reinkensmeyer, David J; Burdet, Etienne; Casadio, Maura; Krakauer, John W; Kwakkel, Gert; Lang, Catherine E; Swinnen, Stephan P; Ward, Nick S; Schweighofer, Nicolas

    2016-01-01

    Despite progress in using computational approaches to inform medicine and neuroscience in the last 30 years, there have been few attempts to model the mechanisms underlying sensorimotor rehabilitation. We argue that a fundamental understanding of neurologic recovery, and as a result accurate predictions at the individual level, will be facilitated by developing computational models of the salient neural processes, including plasticity and learning systems of the brain, and integrating them into a context specific to rehabilitation. Here, we therefore discuss Computational Neurorehabilitation, a newly emerging field aimed at modeling plasticity and motor learning to understand and improve movement recovery of individuals with neurologic impairment. We first explain how the emergence of robotics and wearable sensors for rehabilitation is providing data that make development and testing of such models increasingly feasible. We then review key aspects of plasticity and motor learning that such models will incorporate. We proceed by discussing how computational neurorehabilitation models relate to the current benchmark in rehabilitation modeling - regression-based, prognostic modeling. We then critically discuss the first computational neurorehabilitation models, which have primarily focused on modeling rehabilitation of the upper extremity after stroke, and show how even simple models have produced novel ideas for future investigation. Finally, we conclude with key directions for future research, anticipating that soon we will see the emergence of mechanistic models of motor recovery that are informed by clinical imaging results and driven by the actual movement content of rehabilitation therapy as well as wearable sensor-based records of daily activity.

  9. A Fractional Order Recovery SIR Model from a Stochastic Process.

    Science.gov (United States)

    Angstmann, C N; Henry, B I; McGann, A V

    2016-03-01

    Over the past several decades, there has been a proliferation of epidemiological models with ordinary derivatives replaced by fractional derivatives in an ad hoc manner. These models may be mathematically interesting, but their relevance is uncertain. Here we develop an SIR model for an epidemic, including vital dynamics, from an underlying stochastic process. We show how fractional differential operators arise naturally in these models whenever the recovery time from the disease is power-law distributed. This can provide a model for a chronic disease process where individuals who are infected for a long time are unlikely to recover. The fractional order recovery model is shown to be consistent with the Kermack-McKendrick age-structured SIR model, and it reduces to the Hethcote-Tudor integral equation SIR model. The derivation from a stochastic process is extended to discrete time, providing a stable numerical method for solving the model equations. We have carried out simulations of the fractional order recovery model showing convergence to equilibrium states. The number of infecteds in the endemic equilibrium state increases as the fractional order of the derivative tends to zero.

  10. Modelling of carry-over in recovery furnaces

    Energy Technology Data Exchange (ETDEWEB)

    Fakhrai, Reza [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Metallurgy

    2000-04-01

    Development of mathematical modelling of the combustion process in the furnace of recovery boilers is the subject of this work. This work as a continuation of many years of modelling efforts carried out at KTH/Vaerme- och Ugnsteknik focussed particularly on: char bed modelling; droplets-wall interaction modelling; and carry-over modelling. The char bed model has been studied. Droplets/parcels were considered as a single reactor working independently of the other droplets. The mass of the droplets was not distributed uniformly but induced in the landing place. The droplets hitting the char bed will stick to it and they are alive and part of the calculation. In this way the distribution of the mass on the char bed is only dependent on the parameters which effect flight history such as droplet/parcel diameter, boilers flow field, etc. The droplet- wall interaction model has been studied and found to be very important for obtaining the correct temperature distribution in the recovery furnace. The new approach is based on removal of droplets which hits the wall in the upper part of the recovery boiler from carryover calculation. This model has been proposed and implemented into the GRFM (General Recovery Furnace Model). The carryover modelling effort was based on mass balance in which the number and physical statistics of the droplets/parcel were estimated and the amount of unburned mass was calculated. All of the above listed models were tested together with all other models of heat and mass transfer processes in recovery furnaces using a GRFM. Three-dimensional numerical simulations of the industrial recovery boiler (63 kg/s, 82 bar, 480 deg C) were performed. The number of grid was 232,000 and the number of air ports in this simulation was 178. The air entering the furnace by these ports has different flow rates. Flow and temperature fields as well as species distributions were calculated. The results show good agreement with previously published data and modelling

  11. Foam for Enhanced Oil Recovery: Modeling and Analytical Solutions

    NARCIS (Netherlands)

    Ashoori, E.

    2012-01-01

    Foam increases sweep in miscible- and immiscible-gas enhanced oil recovery by decreasing the mobility of gas enormously. This thesis is concerned with the simulations and analytical solutions for foam flow for the purpose of modeling foam EOR in a reservoir. For the ultimate goal of upscaling our mo

  12. Foam for Enhanced Oil Recovery: Modeling and Analytical Solutions

    NARCIS (Netherlands)

    Ashoori, E.

    2012-01-01

    Foam increases sweep in miscible- and immiscible-gas enhanced oil recovery by decreasing the mobility of gas enormously. This thesis is concerned with the simulations and analytical solutions for foam flow for the purpose of modeling foam EOR in a reservoir. For the ultimate goal of upscaling our mo

  13. Mathematical models for Enterococcus faecalis recovery after microwave water disinfection.

    Science.gov (United States)

    Benjamin, Earl; Reznik, Aron; Benjamin, Ellis; Pramanik, Saroj K; Sowers, Louise; Williams, Arthur L

    2009-12-01

    Microwave water disinfection is a rapid purification technique which can give billions of people access to clean drinking water. However, better understanding of bacterial recovery after microwave heating over time is necessary to determine parameters such as delayed bacterial growth rates and maximum bacterial yields. Mathematical models for Enterococcus faecalis recovery after microwave treatment in optimum growth conditions were developed for times up to 5 minutes using an optical absorbance method. Microwave times below 3 minutes (2,450 MHz, 130W) showed that bacterial recovery maintained a time-dependent sigmoidal form which included a maximum value. At microwave times greater than three minutes, bacterial recovery, with a time-dependent exponential form, significantly decreased and did not reach the maximum value within the interval of observance (0-8 hours). No bacterial growth was found after 6 minutes of microwave treatment. The prepared mathematical models were produced by transforming the given variables to the logistic or exponential functions. We found that time-dependent maximum growth rates and lag times could be approximated with second order polynomial functions. The determined models can be used as a template to illustrate bacterial survival during water purification using microwave irradiation, in both commercial and industrial processes.

  14. Establishing endangered species recovery criteria using predictive simulation modeling

    Science.gov (United States)

    McGowan, Conor P.; Catlin, Daniel H.; Shaffer, Terry L.; Gratto-Trevor, Cheri L.; Aron, Carol

    2014-01-01

    Listing a species under the Endangered Species Act (ESA) and developing a recovery plan requires U.S. Fish and Wildlife Service to establish specific and measurable criteria for delisting. Generally, species are listed because they face (or are perceived to face) elevated risk of extinction due to issues such as habitat loss, invasive species, or other factors. Recovery plans identify recovery criteria that reduce extinction risk to an acceptable level. It logically follows that the recovery criteria, the defined conditions for removing a species from ESA protections, need to be closely related to extinction risk. Extinction probability is a population parameter estimated with a model that uses current demographic information to project the population into the future over a number of replicates, calculating the proportion of replicated populations that go extinct. We simulated extinction probabilities of piping plovers in the Great Plains and estimated the relationship between extinction probability and various demographic parameters. We tested the fit of regression models linking initial abundance, productivity, or population growth rate to extinction risk, and then, using the regression parameter estimates, determined the conditions required to reduce extinction probability to some pre-defined acceptable threshold. Binomial regression models with mean population growth rate and the natural log of initial abundance were the best predictors of extinction probability 50 years into the future. For example, based on our regression models, an initial abundance of approximately 2400 females with an expected mean population growth rate of 1.0 will limit extinction risk for piping plovers in the Great Plains to less than 0.048. Our method provides a straightforward way of developing specific and measurable recovery criteria linked directly to the core issue of extinction risk. Published by Elsevier Ltd.

  15. Developing a model of recovery in mental health

    Directory of Open Access Journals (Sweden)

    Morissette Raymond

    2009-05-01

    Full Text Available Abstract Background The recovery process is characterized by the interaction of a set of individual, environmental and organizational conditions common to different people suffering with a mental health problem. The fact that most of the studies have been working with schizophrenic patients we cannot extend what has been learned about the process of recovery to other types of mental problem. In the meantime, the prevalence of anxiety, affective and borderline personality disorders continues to increase, imposing a significant socioeconomic burden on the Canadian healthcare system and on the patients, their family and significant other 1. The aim of this study is to put forward a theoretical model of the recovery process for people with mental health problem schizophrenic, affective, anxiety and borderline personality disorders, family members and a significant care provider. Method and design To operationalize the study, a qualitative, inductive design was chosen. Qualitative research open the way to learning – the inside – about different perspectives and issues people face in their process of recovery. The study proposal is involving a multisite study that will be conducted in three different cities of the Province of Québec in Canada: Montréal, Québec and Trois-Rivières. The plan is to select 108 participants, divided into four comparison groups representing four types of mental health problem. Each comparison group (n = 27 will be made up of 9 units. Each unit will comprise one person with a mental health problem (schizophrenia, affective anxiety, and borderline personality disorders. Data will be collected through semi-structured open-ended interview. The in-depth qualitative analysis inspired from the grounded theory approach will permit the illustration of the recovery process. Discussion The transformation of our Health Care System and the importance being put on the people well-being and autonomy development of the person who

  16. Sublinear Time, Approximate Model-based Sparse Recovery For All

    CERN Document Server

    Kyrillidis, Anastasios

    2012-01-01

    We describe a probabilistic, {\\it sublinear} runtime, measurement-optimal system for model-based sparse recovery problems through dimensionality reducing, {\\em dense} random matrices. Specifically, we obtain a linear sketch $u\\in \\R^M$ of a vector $\\bestsignal\\in \\R^N$ in high-dimensions through a matrix $\\Phi \\in \\R^{M\\times N}$ $(Mmodel-based sparsity. We construct the dense measurement matrix using a probabilistic method so that it satisfies the so-called restricted isometry property in the $\\ell_2$-norm. While recovery using such matrices is measurement-optimal as they require the smallest sketch sizes $\

  17. Liberdade e compulsão: uma análise da programação dos doze passos dos alcoólicos anônimos Freedom and compulsion: an analysis of twelve steps programming of alcoholics anonymous

    Directory of Open Access Journals (Sweden)

    Joelson Tavares Rodrigues

    2002-06-01

    Full Text Available O presente trabalho se propõe a questionar se a admissão da impotência, inserida nos Doze Passos dos Alcoólicos Anônimos, se confronta com a noção sartreana de liberdade, marcando uma posição tomada pelo AA de entender o alcoolismo como uma compulsão, em que somente a ação de uma força externa pode proporcionar a recuperação. Os autores concluem que, se a programação dos Doze Passos tem sido tão repleta de êxitos, é porque ela, mesmo sem disso dar-se conta, vem trabalhando com a dimensão da escolha, que permite que cada um possa, a todo momento, determinar seu destino.The present paper aims to question if the admission of impotence, included in the twelve steps of alcoholics anonymous, it is against Sartre’s notion of freedom, indicating a position taken by AA of understanding alcoholism as a compulsion, where only the action of an external power can provide recuperation. The authors conclude that, if the programming of twelve steps has been having so effective is because, even when not aware, it has been working with the dimension of choice that allows that each person can at every moment determinate his own destiny.

  18. Computational Modeling Basis in the Photostress Recovery Model (PREMO)

    Science.gov (United States)

    2014-09-01

    13 Figure 8. The decay of the EBL after the exposure is terminated ....................................15 Figure...equivalent background luminance ( EBL ).11 In addition, both glare and photostress recovery effects depend not only on the parameters of the inducing light...combined image is known as the EBL reduced visual task image ),( yxERVT and it is given by: ),(),(),( yxVTyxEBLyxERVT += , (27) where EBL (x,y) is the

  19. [The Global Model of Public Mental Health and Recovery Mentors].

    Science.gov (United States)

    Pelletier, Jean-François; Auclair, Émilie

    2017-01-01

    Objectives The aim of this paper is to revisit the Global Model of Public Mental Health (GMPMH) in light of the 4th Civic Forum. Recovery mentors of the University of Recovery chaired this public event, which was held in East-end Montreal, Canada, in 2016. The University of Recovery is a concept of co-learning among its members.Methods Being able to refer to international conventions and human rights standards is a key component of a genuine global approach that is supportive of individuals and communities in their quest for recovery and full citizenship. The GMPMH was inspired by the ecological approach in public health and health promotion programs, while adding to that approach the recovery mentors, as agents of mental health policies and legislation transformation. The GMPMH integrates recovery- and citizenship-oriented practices through the Ottawa Charter for Health Promotion of the World Health Organization. Indeed, here the GMPMH is said to be global in that the supranational and individual levels reinforce each other, taking turns with a) a set of legal rules and international conventions on human rights, including those of disabled persons, and b) the active involvement and agency of recovery mentors who can evoke these rules and conventions as part of a plea for the recognition of their personal and collective capacity for change; they acted as tracers of recovery trajectories during the Civic Forum. The GMPMH was first published in 2009, and revisited in 2013. While this latter revision was based on the 3rd Civic Forum, in this paper we use the same approach to revisit the GMPMH as underpinned by the findings and recommendations of the 4th Civic Forum, which discussed questions related to work and employment.Results Updating the GMPMH in light of the Civic Forum underlines the need for a more inclusive type of governance regarding policy and systems transformation. Local communities and persons in recovery can reach each other to promote change and

  20. Enhanced oil recovery by nanoparticles injection: Modeling and simulation

    KAUST Repository

    El-Amin, Mohamed

    2013-01-01

    In the present paper, a mathematical model and numerical simulation to describe the nanoparticles-water suspension imbibes into a water-oil two-phase flow in a porous medium is introduced. We extend the model to include the negative capillary pressure and mixed relative permeabilities correlations to fit with the mixed-wet system. Also, buoyancy and capillary forces as well as Brownian diffusion are considered. Throughout this investigation, we monitor the changing of the fluids and solid properties due to addition of the nanoparticles and check for possible enhancement of the oil recovery process using numerical experiments.

  1. Modelling the heat stress and the recovery of bacterial spores.

    Science.gov (United States)

    Mafart, P; Leguérinel, I

    1997-07-22

    After heat treatment, the temperature incubation and the medium composition, (pH and sodium chloride content) influence the capacity of injured spores to repair heat damage. The concept of heat resistance D- (decimal reduction time) and z-values (temperature increase which results in a ten fold reduction of the D value) is not sufficient and the ratio of spore recovery after incubation should be considered in calculations used in thermal processing of food. This paper aims to derive a model describing the recovery of injured spores as a function of both the heat treatment intensity and the environmental conditions. According to data from numerous investigators, when spores are incubated in unfavorable conditions, the ratio of cell recovery and the apparent D-value are reduced. Moreover the ratio of the apparent D-value and the estimated in optimal incubation D-value is constant and independent of the heat treatment conditions. Beyond these observations it is shown that the ratio of cell recovery with respect to the heat treatment F-value (exposure time, in minutes, at 121.1 degrees C which results in the same destruction ratio that the considered heat treatment does) is linear and can be quantified by using two factors independent of the heat treatment: the gamma-factor reflects the degree of precariousness due to the heat stress while the epsilon-factor reflects more intrinsically the incubation conditions without previous heat treatment. The gamma-factor varies as a function of the incubation temperature according to an Arrhenius law.

  2. Neuromotor recovery from stroke: Computational models at central, functional, and muscle synergy level

    Directory of Open Access Journals (Sweden)

    Maura eCasadio

    2013-08-01

    Full Text Available Computational models of neuromotor recovery after a stroke might help to unveil the underlying physiological mechanisms and might suggest how to make recovery faster and more effective. At least in principle, these models could serve: (i To provide testable hypotheses on the nature of recovery; (ii To predict the recovery of individual patients; (iii To design patient-specific ’optimal’ therapy, by setting the treatment variables for maximizing the amount of recovery or for achieving a better generalization of the learned abilities across different tasks.Here we review the state of the art of computational models for neuromotor recovery through exercise, and their implications for treatment. We show that to properly account for the computational mechanisms of neuromotor recovery, multiple levels of description need to be taken into account. The review specifically covers models of recovery at central, functional and muscle synergy level.

  3. Energy recovery from solid waste. [production engineering model

    Science.gov (United States)

    Dalton, C.; Huang, C. J.

    1974-01-01

    A recent group study on the problem of solid waste disposal provided a decision making model for a community to use in determining the future for its solid waste. The model is a combination of the following factors: technology, legal, social, political, economic and environmental. An assessment of local or community needs determines what form of energy recovery is desirable. A market for low pressure steam or hot water would direct a community to recover energy from solid waste by incineration to generate steam. A fuel gas could be produced by a process known as pyrolysis if there is a local market for a low heating value gaseous fuel. Solid waste can also be used directly as a fuel supplemental to coal in a steam generator. An evaluation of these various processes is made.

  4. Energy recovery from solid waste. [production engineering model

    Science.gov (United States)

    Dalton, C.; Huang, C. J.

    1974-01-01

    A recent group study on the problem of solid waste disposal provided a decision making model for a community to use in determining the future for its solid waste. The model is a combination of the following factors: technology, legal, social, political, economic and environmental. An assessment of local or community needs determines what form of energy recovery is desirable. A market for low pressure steam or hot water would direct a community to recover energy from solid waste by incineration to generate steam. A fuel gas could be produced by a process known as pyrolysis if there is a local market for a low heating value gaseous fuel. Solid waste can also be used directly as a fuel supplemental to coal in a steam generator. An evaluation of these various processes is made.

  5. Modeling of sodium acetate recovery from aqueous solutions by electrodialysis.

    Science.gov (United States)

    Fidaleo, Marcello; Moresi, Mauro

    2005-09-05

    The main engineering parameters (i.e., ion transport numbers in solution and electro-membranes; effective solute and water transport numbers; effective membrane surface area, membrane surface resistances, and limiting current intensity) affecting the recovery of sodium acetate from model solutions by electrodialysis (ED) were determined in accordance with a sequential experimental procedure. Such parameters allowed a satisfactory simulation of a few validation tests carried out under constant or step-wisely variable current intensity. The performance of this ED process was characterized in terms of a current efficiency (omega) of about 93% in the constant-current region, a water transport number (t(W)) of about 15, and a specific energy consumption (epsilon) increasing from 0.14 to 0.31 kWh/kg for a solute recovery yield of 95% as the current density (j) was increased from 112 to 337 A/m2. The specific resistance of the anion- or cation-exchange membranes were found to be three or two times greater than those measured in aqueous NaCl solutions and are to be used to design and/or optimize ED stacks involved in the downstream processing of acetic acid fermentation broths.

  6. Collaborative recovery: an integrative model for working with individuals who experience chronic and recurring mental illness.

    Science.gov (United States)

    Oades, Lindsay; Deane, Frank; Crowe, Trevor; Lambert, W Gordon; Kavanagh, David; Lloyd, Chris

    2005-09-01

    Recovery is an emerging movement in mental health. Evidence for recovery-based approaches is not well developed and approaches to implement recovery-oriented services are not well articulated. The collaborative recovery model (CRM) is presented as a model that assists clinicians to use evidence-based skills with consumers, in a manner consistent with the recovery movement. A current 5 year multisite Australian study to evaluate the effectiveness of CRM is briefly described. The collaborative recovery model puts into practice several aspects of policy regarding recovery-oriented services, using evidence-based practices to assist individuals who have chronic or recurring mental disorders (CRMD). It is argued that this model provides an integrative framework combining (i) evidence-based practice; (ii) manageable and modularized competencies relevant to case management and psychosocial rehabilitation contexts; and (iii) recognition of the subjective experiences of consumers.

  7. Modeling a Thermoelectric Generator Applied to Diesel Automotive Heat Recovery

    Science.gov (United States)

    Espinosa, N.; Lazard, M.; Aixala, L.; Scherrer, H.

    2010-09-01

    Thermoelectric generators (TEGs) are outstanding devices for automotive waste heat recovery. Their packaging, lack of moving parts, and direct heat to electrical conversion are the main benefits. Usually, TEGs are modeled with a constant hot-source temperature. However, energy in exhaust gases is limited, thus leading to a temperature decrease as heat is recovered. Therefore thermoelectric properties change along the TEG, affecting performance. A thermoelectric generator composed of Mg2Si/Zn4Sb3 for high temperatures followed by Bi2Te3 for low temperatures has been modeled using engineering equation solver (EES) software. The model uses the finite-difference method with a strip-fins convective heat transfer coefficient. It has been validated on a commercial module with well-known properties. The thermoelectric connection and the number of thermoelements have been addressed as well as the optimum proportion of high-temperature material for a given thermoelectric heat exchanger. TEG output power has been estimated for a typical commercial vehicle at 90°C coolant temperature.

  8. System Modeling for Ammonia Synthesis Energy Recovery System

    Science.gov (United States)

    Bran Anleu, Gabriela; Kavehpour, Pirouz; Lavine, Adrienne; Ammonia thermochemical Energy Storage Team

    2015-11-01

    An ammonia thermochemical energy storage system is an alternative solution to the state-of-the-art molten salt TES system for concentrating solar power. Some of the advantages of this emerging technology include its high energy density, no heat losses during the storage duration, and the possibility of long storage periods. Solar energy powers an endothermic reaction to disassociate ammonia into hydrogen and nitrogen, which can be stored for future use. The reverse reaction is carried out in the energy recovery process; a hydrogen-nitrogen mixture flowing through a catalyst bed undergoes the exothermic ammonia synthesis reaction. The goal is to use the ammonia synthesis reaction to heat supercritical steam to temperatures on the order of 650°C as required for a supercritical steam Rankine cycle. The steam will flow through channels in a combined reactor-heat exchanger. A numerical model has been developed to determine the optimal design to heat supercritical steam while maintaining a stable exothermic reaction. The model consists of a transient one dimensional concentric tube counter-flow reactor-heat exchanger. The numerical model determines the inlet mixture conditions needed to achieve various steam outlet conditions.

  9. Model Based Aircraft Upset Detection and Recovery System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal describes a system for detecting upset conditions and providing the corresponding control recovery actions to maintain flight integrity for general...

  10. Aquifer Storage and Recovery : Physical and Geochemical Modelling (SWIFTPHREEQC)of British Aquifers for Aquifer Storage and Recovery Purposes. Part 1, physical modelling and geochemical model calibration

    OpenAIRE

    2000-01-01

    This report describes the progress that has been made in developing models simulating both the physical and geochemical aspects of Aquifer Storage Recovery (ASR) schemes. This work is part of a 30 month project, entitled ASR-UK, which started in April 1999. The report describes progress to the end of 1999. SWIFT is a fully transient 3-Dimensional model that simulates flow and transport of fluids. It is ideally suited to modelling ASR and has been used to simulate the response o...

  11. Bond and CDS Pricing via the Stochastic Recovery Black-Cox Model

    Directory of Open Access Journals (Sweden)

    Albert Cohen

    2017-04-01

    Full Text Available Building on recent work incorporating recovery risk into structural models by Cohen & Costanzino (2015, we consider the Black-Cox model with an added recovery risk driver. The recovery risk driver arises naturally in the context of imperfect information implicit in the structural framework. This leads to a two-factor structural model we call the Stochastic Recovery Black-Cox model, whereby the asset risk driver At defines the default trigger and the recovery risk driver Rt defines the amount recovered in the event of default. We then price zero-coupon bonds and credit default swaps under the Stochastic Recovery Black-Cox model. Finally, we compare our results with the classic Black-Cox model, give explicit expressions for the recovery risk premium in the Stochastic Recovery Black-Cox model, and detail how the introduction of separate but correlated risk drivers leads to a decoupling of the default and recovery risk premiums in the credit spread. We conclude this work by computing the effect of adding coupons that are paid continuously until default, and price perpetual (consol bonds in our two-factor firm value model, extending calculations in the seminal paper by Leland (1994.

  12. A Proposed Model for IT Disaster Recovery Plan

    Directory of Open Access Journals (Sweden)

    Hossam Abdel Rahman Mohamed

    2014-04-01

    Full Text Available IT disaster recovery planning is no longer an option. Reliable IT services have become an integral part of most business processes. To ensure the continued provision of information technology, firms must engage in IT disaster recovery planning. Surprisingly, there is little research on this topic. IT disaster recovery planning has not been fully conceptualized in mainstream IT research. A previously framework for assessing the degree of IT disaster recovery planning. Practitioners can use this study to guide IT disaster recovery planning. Our Disaster Recovery Plan is designed to ensure the continuation of vital business processes in the event that a disaster occurs. This plan will provide an effective solution that can be used to recover all vital business processes within the required time frame using vital records that are stored off-site. This Plan is just one of several plans that will provide procedures to handle emergency situations. These plans can be utilized individually but are designed to support one another. The first phase is a Functional Teams and Responsibilities the Crisis Management Plan. This phase allows the ability to handle high-level coordination activities surrounding any crisis situation. We will also discuss the development, finally maintenance and testing of the Disaster Recovery Plan.

  13. Mechanical model of the recovery reaction from stumbling: effect of step length on trunk control

    NARCIS (Netherlands)

    Forner-Cordero, A.; Koopman, H.F.J.M.; Helm, van der F.C.T.

    2014-01-01

    Falling after a gait perturbation is a major problem for elderly people. The goal of this paper is to model some mechanical limitations of the recovery strategies performed after a trip or stumble, such as elevating or lowering strategies. A biomechanical model of the recovery was used to interpret

  14. Recovery Kinetics in Commercial Purity Aluminum Deformed to Ultrahigh Strain: Model and Experiment

    DEFF Research Database (Denmark)

    Yu, Tianbo; Hansen, Niels

    2016-01-01

    for recovery. This approach is applied to commercial purity aluminum (AA1050) cold rolled to ultrahigh strain (99.6 pct reduction in thickness) and annealed at temperatures from 413 K to 493 K (140 A degrees C to 220 A degrees C). The annealing data fit the recovery model well, and the analysis shows......A new approach to analyze recovery kinetics is developed from a recent model, and microstructural observations are introduced to supplement hardness measurements. The approach involves two steps of data fitting, and the second step of fitting enables an estimation of the apparent activation energy...... that the apparent activation energy increases during recovery and approaches 190 kJ/mol at the end of recovery, suggesting that solute drag is an important rate-controlling mechanism. The recovery rate for the highly strained Al is found to be higher than that for Al deformed to a lower strain, an effect which...

  15. DEVELOPMENT OF BIOSURFACTANT-MEDIATED OIL RECOVERY IN MODEL POROUS SYSTEMS AND COMPUTER SIMULATIONS OF BIOSURFACTANT-MEDIATED OIL RECOVERY

    Energy Technology Data Exchange (ETDEWEB)

    M.J. McInerney; S.K. Maudgalya; R. Knapp; M. Folmsbee

    2004-05-31

    Current technology recovers only one-third to one-half of the oil that is originally present in an oil reservoir. Entrapment of petroleum hydrocarbons by capillary forces is a major factor that limits oil recovery (1, 3, 4). Hydrocarbon displacement can occur if interfacial tension (IFT) between the hydrocarbon and aqueous phases is reduced by several orders of magnitude. Microbially-produced biosurfactants may be an economical method to recover residual hydrocarbons since they are effective at low concentrations. Previously, we showed that substantial mobilization of residual hydrocarbon from a model porous system occurs at biosurfactant concentrations made naturally by B. mojavensis strain JF-1 if a polymer and 2,3-butanediol were present (2). In this report, we include data on oil recovery from Berea sandstone experiments along with our previous data from sand pack columns in order to relate biosurfactant concentration to the fraction of oil recovered. We also investigate the effect that the JF-2 biosurfactant has on interfacial tension (IFT). The presence of a co-surfactant, 2,3-butanediol, was shown to improve oil recoveries possibly by changing the optimal salinity concentration of the formulation. The JF-2 biosurfactant lowered IFT by nearly 2 orders of magnitude compared to typical values of 28-29 mN/m. Increasing the salinity increased the IFT with or without 2,3-butanediol present. The lowest interfacial tension observed was 0.1 mN/m. Tertiary oil recovery experiments showed that biosurfactant solutions with concentrations ranging from 10 to 60 mg/l in the presence of 0.1 mM 2,3-butanediol and 1 g/l of partially hydrolyzed polyacrylamide (PHPA) recovered 10-40% of the residual oil present in Berea sandstone cores. When PHPA was used alone, about 10% of the residual oil was recovered. Thus, about 10% of the residual oil recovered in these experiments was due to the increase in viscosity of the displacing fluid. Little or no oil was recovered at

  16. Using Appreciative Inquiry to Facilitate Implementation of the Recovery Model in Mental Health Agencies

    Science.gov (United States)

    Clossey, Laurene; Mehnert, Kevin; Silva, Sara

    2011-01-01

    This article describes an organizational development tool called appreciative inquiry (AI) and its use in mental health to aid agencies implementing recovery model services. AI is a discursive tool with the power to shift dominant organizational cultures. Its philosophical underpinnings emphasize values consistent with recovery: community,…

  17. Modeling and Recovery of Iron (Fe) from Red Mud by Coal Reduction

    Science.gov (United States)

    Zhao, Xiancong; Li, Hongxu; Wang, Lei; Zhang, Lifeng

    Recovery of Fe from red mud has been studied using statistically designed experiments. The effects of three factors, namely: reduction temperature, reduction time and proportion of additive on recovery of Fe have been investigated. Experiments have been carried out using orthogonal central composite design and factorial design methods. A model has been obtained through variance analysis at 92.5% confidence level.

  18. Model predictive control of a waste heat recovery system for automotive diesel engines

    NARCIS (Netherlands)

    Feru, E.; Willems, F.; De Jager, B.; Steinbuch, M.

    2014-01-01

    In this paper, a switching Model Predictive Control strategy is designed for an automotive Waste Heat Recovery system with two parallel evaporators. The objective is to maximize Waste Heat Recovery system output power, while satisfying safe operation under highly dynamic disturbances from the engine

  19. A system dynamics approach to develop a recovery model in the Malaysian automotive industry

    Science.gov (United States)

    Mohamad-Ali, N.; Ghazilla, R. A. R.; Abdul-Rashid, S. H.; Sakundarini, N.; Ahmad-Yazid, A.; Stephenie, L.

    2017-06-01

    Design strategies play a significant role to enhance recovery effectiveness at the end of product life cycle. By reviewing previous study, there are many factors involved to enhance recovery effectiveness but limited to linking design strategies factors in holistic and dynamics view. Proposed method are explained and an initial model for end-of-life vehicles (ELVs) recovery model illustrated in graphical and numerical data is presented. However this is limited to authors understanding and preliminary data which requires collaboration between designers and other stakeholders to develop a model based on actual situation.

  20. Modeling Soil Quality Thresholds to Ecosystem Recovery at Fort Benning, Georgia, USA

    Energy Technology Data Exchange (ETDEWEB)

    Garten Jr., C.T.

    2004-03-08

    The objective of this research was to use a simple model of soil C and N dynamics to predict nutrient thresholds to ecosystem recovery on degraded soils at Fort Benning, Georgia, in the southeastern USA. The model calculates aboveground and belowground biomass, soil C inputs and dynamics, soil N stocks and availability, and plant N requirements. A threshold is crossed when predicted soil N supplies fall short of predicted N required to sustain biomass accrual at a specified recovery rate. Four factors were important to development of thresholds to recovery: (1) initial amounts of aboveground biomass, (2) initial soil C stocks (i.e., soil quality), (3) relative recovery rates of biomass, and (4) soil sand content. Thresholds to ecosystem recovery predicted by the model should not be interpreted independent of a specified recovery rate. Initial soil C stocks influenced the predicted patterns of recovery by both old field and forest ecosystems. Forests and old fields on soils with varying sand content had different predicted thresholds to recovery. Soil C stocks at barren sites on Fort Benning generally lie below predicted thresholds to 100% recovery of desired future ecosystem conditions defined on the basis of aboveground biomass (18000 versus 360 g m{sup -2} for forests and old fields, respectively). Calculations with the model indicated that reestablishment of vegetation on barren sites to a level below the desired future condition is possible at recovery rates used in the model, but the time to 100% recovery of desired future conditions, without crossing a nutrient threshold, is prolonged by a reduced rate of forest growth. Predicted thresholds to ecosystem recovery were less on soils with more than 70% sand content. The lower thresholds for old field and forest recovery on more sandy soils are apparently due to higher relative rates of net soil N mineralization in more sandy soils. Calculations with the model indicate that a combination of desired future

  1. Recovery Kinetics in Commercial Purity Aluminum Deformed to Ultrahigh Strain: Model and Experiment

    DEFF Research Database (Denmark)

    Yu, Tianbo; Hansen, Niels

    2016-01-01

    A new approach to analyze recovery kinetics is developed from a recent model, and microstructural observations are introduced to supplement hardness measurements. The approach involves two steps of data fitting, and the second step of fitting enables an estimation of the apparent activation energy...... that the apparent activation energy increases during recovery and approaches 190 kJ/mol at the end of recovery, suggesting that solute drag is an important rate-controlling mechanism. The recovery rate for the highly strained Al is found to be higher than that for Al deformed to a lower strain, an effect which...... is related to an increase in the stored energy (driving force). These findings form the basis for a discussion of recovery mechanisms and the increase in the apparent activation energy during annealing, suggesting an application of the model when optimizing the structure and strength through annealing...

  2. Analytical recovery of protozoan enumeration methods: have drinking water QMRA models corrected or created bias?

    Science.gov (United States)

    Schmidt, P J; Emelko, M B; Thompson, M E

    2013-05-01

    Quantitative microbial risk assessment (QMRA) is a tool to evaluate the potential implications of pathogens in a water supply or other media and is of increasing interest to regulators. In the case of potentially pathogenic protozoa (e.g. Cryptosporidium oocysts and Giardia cysts), it is well known that the methods used to enumerate (oo)cysts in samples of water and other media can have low and highly variable analytical recovery. In these applications, QMRA has evolved from ignoring analytical recovery to addressing it in point-estimates of risk, and then to addressing variation of analytical recovery in Monte Carlo risk assessments. Often, variation of analytical recovery is addressed in exposure assessment by dividing concentration values that were obtained without consideration of analytical recovery by random beta-distributed recovery values. A simple mathematical proof is provided to demonstrate that this conventional approach to address non-constant analytical recovery in drinking water QMRA will lead to overestimation of mean pathogen concentrations. The bias, which can exceed an order of magnitude, is greatest when low analytical recovery values are common. A simulated dataset is analyzed using a diverse set of approaches to obtain distributions representing temporal variation in the oocyst concentration, and mean annual risk is then computed from each concentration distribution using a simple risk model. This illustrative example demonstrates that the bias associated with mishandling non-constant analytical recovery and non-detect samples can cause drinking water systems to be erroneously classified as surpassing risk thresholds.

  3. Modelling and characterization of primary settlers in view of whole plant and resource recovery modelling.

    Science.gov (United States)

    Bachis, Giulia; Maruéjouls, Thibaud; Tik, Sovanna; Amerlinck, Youri; Melcer, Henryk; Nopens, Ingmar; Lessard, Paul; Vanrolleghem, Peter A

    2015-01-01

    Characterization and modelling of primary settlers have been neglected pretty much to date. However, whole plant and resource recovery modelling requires primary settler model development, as current models lack detail in describing the dynamics and the diversity of the removal process for different particulate fractions. This paper focuses on the improved modelling and experimental characterization of primary settlers. First, a new modelling concept based on particle settling velocity distribution is proposed which is then applied for the development of an improved primary settler model as well as for its characterization under addition of chemicals (chemically enhanced primary treatment, CEPT). This model is compared to two existing simple primary settler models (Otterpohl and Freund; Lessard and Beck), showing to be better than the first one and statistically comparable to the second one, but with easier calibration thanks to the ease with which wastewater characteristics can be translated into model parameters. Second, the changes in the activated sludge model (ASM)-based chemical oxygen demand fractionation between inlet and outlet induced by primary settling is investigated, showing that typical wastewater fractions are modified by primary treatment. As they clearly impact the downstream processes, both model improvements demonstrate the need for more detailed primary settler models in view of whole plant modelling.

  4. Lactic Acid Recovery from Model Solutions and Fermentation Broth by Electrodialysis

    OpenAIRE

    Nolasco-Hipolito, Cirilo; Thang, Vu Hong; Kobayashi, Genta; Sonomoto, Kenji; Ishizaki, Ayaaki

    2001-01-01

    The effect of current density, initial concentration of diluting solution on lactic acid (LA) recovery by electrodialysis from both model solutions and real fermentation broth was investigated. In model solutions, LA recovery efficiency was 93-96% and it was independent of both, current density and initial concentration of diluting solution. The recovery rates at 33, 66 and 100 A・m^ were 76, 175 and 272 g・m^・h^ respectively and, clearly were linearly depended on current density. In the first ...

  5. An assessment of aquifer storage recovery using ground water flow models.

    Science.gov (United States)

    Lowry, Christopher S; Anderson, Mary P

    2006-01-01

    Owing to increased demands on ground water accompanied by increased drawdowns, technologies that use recharge options, such as aquifer storage recovery (ASR), are being used to optimize available water resources and reduce adverse effects of pumping. In this paper, three representative ground water flow models were created to assess the impact of hydrogeologic and operational parameters/factors on recovery efficiency of ASR systems. Flow/particle tracking and solute transport models were used to track the movement of water during injection, storage, and recovery. Results from particle tracking models consistently produced higher recovery efficiency than the solute transport models for the parameters/properties examined because the particle tracking models neglected mixing of the injected and ambient water. Mixing between injected and ambient water affected recovery efficiency. Results from this study demonstrate the interactions between hydrogeologic and operational parameters on predictions of recovery efficiency. These interactions are best simulated using coupled numerical ground water flow and transport models that include the effects of mixing of injected water and ambient ground water.

  6. Recovery orientation of treatment, consumer empowerment, and satisfaction with services: a mediational model.

    Science.gov (United States)

    Barrett, Blake; Young, M Scott; Teague, Gregory B; Winarski, James T; Moore, Kathleen A; Ochshorn, Ezra

    2010-01-01

    This study explores the relationship between the recovery orientation of treatment and subjective experiences of consumer empowerment and satisfaction with services for individuals with severe and persistent mental illness. Instruments measuring perceptions of empowerment, recovery orientation of treatment, and satisfaction with services were administered to 45 participants enrolled in two demographically similar mental health treatment programs in Tampa, Florida - a community mental health center and an Assertive Community Treatment team. Analyses were conducted according to traditional mediation models. Empowerment was expected to mediate the relationship between the recovery orientation of treatment and consumer satisfaction with services. A recovery-based treatment orientation significantly predicted both consumer empowerment and satisfaction with services. Empowerment mediated the relationship between treatment orientation and consumer satisfaction. These preliminary findings highlight the impact of the recovery orientation of treatment on empowerment and satisfaction with services among individuals with severe and persistent mental illness.

  7. Cluster as a Service for Disaster Recovery in Intercloud Systems: Design and Modeling

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Khoshkholghi

    2014-06-01

    Full Text Available Nowadays, all modern IT technologies aim to create dynamic and flexible environments. For this reason, InterCloud has been designed to provide a vast and flexible virtualized environment in which many clouds can interact with one another in a dynamic way. Disaster recovery is one of the main applications of InterCloud which can be supported by Cluster as a Service. However, the previous studies addressed disaster recovery and Cluster as a Service separately. In addition, system backup and disaster recovery methods are not sufficiently effective in InterCloud. In this paper, we propose an InterCloud system which integrates both Cluster as a Service and disaster recovery in a harmonious manner. Also, we present a heuristic approach to select the best locations for system backup and disaster recovery in InterCloud systems. Finally, the proposed system is modeled and analyzed using Continuous-time Markov chains.

  8. Recovery Kinetics in Commercial Purity Aluminum Deformed to Ultrahigh Strain: Model and Experiment

    Science.gov (United States)

    Yu, Tianbo; Hansen, Niels

    2016-08-01

    A new approach to analyze recovery kinetics is developed from a recent model, and microstructural observations are introduced to supplement hardness measurements. The approach involves two steps of data fitting, and the second step of fitting enables an estimation of the apparent activation energy for recovery. This approach is applied to commercial purity aluminum (AA1050) cold rolled to ultrahigh strain (99.6 pct reduction in thickness) and annealed at temperatures from 413 K to 493 K (140 °C to 220 °C). The annealing data fit the recovery model well, and the analysis shows that the apparent activation energy increases during recovery and approaches 190 kJ/mol at the end of recovery, suggesting that solute drag is an important rate-controlling mechanism. The recovery rate for the highly strained Al is found to be higher than that for Al deformed to a lower strain, an effect which is related to an increase in the stored energy (driving force). These findings form the basis for a discussion of recovery mechanisms and the increase in the apparent activation energy during annealing, suggesting an application of the model when optimizing the structure and strength through annealing of nanostructured materials produced by high strain deformation.

  9. Unified model and reverse recovery nonlinearities of the driven diode resonator.

    Science.gov (United States)

    de Moraes, Renato Mariz; Anlage, Steven M

    2003-08-01

    We study the origins of period doubling and chaos in the driven series resistor-inductor-varactor diode (RLD) nonlinear resonant circuit. We find that resonators driven at frequencies much higher than the diode reverse recovery rate do not show period doubling. Models of chaos based on the nonlinear capacitance of the varactor diode display a reverse-recovery-like effect, and this effect strongly resembles reverse recovery of real diodes. We find for the first time that in addition to the known dependence of the reverse recovery time on past current maxima, there are also important nonlinear dependencies on pulse frequency, duty cycle, and dc voltage bias. Similar nonlinearities are present in the nonlinear capacitance models of these diodes. We conclude that a history-dependent and nonlinear reverse-recovery time is an essential ingredient for chaotic behavior of this circuit, and demonstrate for the first time that all major competing models have this effect, either explicitly or implicitly. Besides unifying the two major models of RLD chaos, our work reveals that the nonlinearities of the reverse-recovery time must be included for a complete understanding of period doubling and chaos in this circuit.

  10. Mixed Higher Order Variational Model for Image Recovery

    Directory of Open Access Journals (Sweden)

    Pengfei Liu

    2014-01-01

    Full Text Available A novel mixed higher order regularizer involving the first and second degree image derivatives is proposed in this paper. Using spectral decomposition, we reformulate the new regularizer as a weighted L1-L2 mixed norm of image derivatives. Due to the equivalent formulation of the proposed regularizer, an efficient fast projected gradient algorithm combined with monotone fast iterative shrinkage thresholding, called, FPG-MFISTA, is designed to solve the resulting variational image recovery problems under majorization-minimization framework. Finally, we demonstrate the effectiveness of the proposed regularization scheme by the experimental comparisons with total variation (TV scheme, nonlocal TV scheme, and current second degree methods. Specifically, the proposed approach achieves better results than related state-of-the-art methods in terms of peak signal to ratio (PSNR and restoration quality.

  11. Predicting recovery of cognitive function soon after stroke: differential modeling of logarithmic and linear regression.

    Science.gov (United States)

    Suzuki, Makoto; Sugimura, Yuko; Yamada, Sumio; Omori, Yoshitsugu; Miyamoto, Masaaki; Yamamoto, Jun-ichi

    2013-01-01

    Cognitive disorders in the acute stage of stroke are common and are important independent predictors of adverse outcome in the long term. Despite the impact of cognitive disorders on both patients and their families, it is still difficult to predict the extent or duration of cognitive impairments. The objective of the present study was, therefore, to provide data on predicting the recovery of cognitive function soon after stroke by differential modeling with logarithmic and linear regression. This study included two rounds of data collection comprising 57 stroke patients enrolled in the first round for the purpose of identifying the time course of cognitive recovery in the early-phase group data, and 43 stroke patients in the second round for the purpose of ensuring that the correlation of the early-phase group data applied to the prediction of each individual's degree of cognitive recovery. In the first round, Mini-Mental State Examination (MMSE) scores were assessed 3 times during hospitalization, and the scores were regressed on the logarithm and linear of time. In the second round, calculations of MMSE scores were made for the first two scoring times after admission to tailor the structures of logarithmic and linear regression formulae to fit an individual's degree of functional recovery. The time course of early-phase recovery for cognitive functions resembled both logarithmic and linear functions. However, MMSE scores sampled at two baseline points based on logarithmic regression modeling could estimate prediction of cognitive recovery more accurately than could linear regression modeling (logarithmic modeling, R(2) = 0.676, Plinear regression modeling, R(2) = 0.598, P<0.0001). Logarithmic modeling based on MMSE scores could accurately predict the recovery of cognitive function soon after the occurrence of stroke. This logarithmic modeling with mathematical procedures is simple enough to be adopted in daily clinical practice.

  12. Predicting recovery of cognitive function soon after stroke: differential modeling of logarithmic and linear regression.

    Directory of Open Access Journals (Sweden)

    Makoto Suzuki

    Full Text Available Cognitive disorders in the acute stage of stroke are common and are important independent predictors of adverse outcome in the long term. Despite the impact of cognitive disorders on both patients and their families, it is still difficult to predict the extent or duration of cognitive impairments. The objective of the present study was, therefore, to provide data on predicting the recovery of cognitive function soon after stroke by differential modeling with logarithmic and linear regression. This study included two rounds of data collection comprising 57 stroke patients enrolled in the first round for the purpose of identifying the time course of cognitive recovery in the early-phase group data, and 43 stroke patients in the second round for the purpose of ensuring that the correlation of the early-phase group data applied to the prediction of each individual's degree of cognitive recovery. In the first round, Mini-Mental State Examination (MMSE scores were assessed 3 times during hospitalization, and the scores were regressed on the logarithm and linear of time. In the second round, calculations of MMSE scores were made for the first two scoring times after admission to tailor the structures of logarithmic and linear regression formulae to fit an individual's degree of functional recovery. The time course of early-phase recovery for cognitive functions resembled both logarithmic and linear functions. However, MMSE scores sampled at two baseline points based on logarithmic regression modeling could estimate prediction of cognitive recovery more accurately than could linear regression modeling (logarithmic modeling, R(2 = 0.676, P<0.0001; linear regression modeling, R(2 = 0.598, P<0.0001. Logarithmic modeling based on MMSE scores could accurately predict the recovery of cognitive function soon after the occurrence of stroke. This logarithmic modeling with mathematical procedures is simple enough to be adopted in daily clinical practice.

  13. Dynamic Modeling of Hydrogen Sulfide within Enclosed Environments in Biosolids Recovery Facilities.

    Science.gov (United States)

    Matos, Rita Ventura; Matias, Natércia; Ferreira, Filipa; Matos, José Saldanha

    2016-12-01

      Hydrogen sulfide emissions from wastewater affect human health and equipment durability, thus presenting a complex issue for utilities. Several VOC emission models have been used before to predict H2S in collection systems and water resources recovery operations, even if with restrictions. By contrast, fewer studies focus on biosolids emissions and modelling. This paper presents a dynamic modelling approach to predict H2S concentration in a tank headspace of a wastewater biosolids recovery facility. Data from one of the largest Portuguese water resources recovery facilities was collected under different facility operating modes. The developed model adequately predicted H2S concentration, with R2 values of 0.89 and 0.78, for different periods of the year, thus showing how modelling may reliably contribute to utility operation decisions.

  14. An analytical model for predicting LNAPL distribution and recovery from multi-layered soils.

    Science.gov (United States)

    Jeong, Jaehak; Charbeneau, Randall J

    2014-01-01

    An analytical model was developed for estimating the distribution and recovery of light nonaqueous phase liquids (LNAPL) in heterogeneous aquifers. Various scenarios of LNAPL recovery may be simulated using LDRM for LNAPL recovery systems such as skimmer wells, water-enhanced wells, air-enhanced wells, and trenches from heterogeneous aquifers. LDRM uses multiple horizontal soil layers to model a heterogeneous aquifer. Up to three soil layers may be configured with unique soil properties for each layer. Simulation results suggest that LNAPL distribution and its recovery volume are highly affected by soil properties. In sandy soils LNAPL can be highly mobile and the recovery efficiency can be high. In contrast, even at high LNAPL saturations, LNAPL mobility is typically low in fine-grained soils. This characteristic of LNAPL with respect to soil texture has to be carefully accounted for in the model to better predict the recovery of LNAPL from heterogeneous soils. The impact of vertical hydraulic gradient in fine grain zone was assessed. A sensitivity analysis suggests that the formation LNAPL volume can be significantly affected by a downward vertical hydraulic gradient if the magnitude is near a critical amount (=ρr-1). Sensitivity of input parameters with respect to LNAPL formation in soils and LNAPL recovery volume were identified through a sensitivity analysis. The performance of LDRM on predicting the distribution and recovery of LNAP was reasonably accurate for a short-term analysis as demonstrated in a case study. However, further validation is needed to ascertain the model's performance in long-term simulations.

  15. The models of optimization for increasing of copper and gold recoveries in Bucim Mine

    OpenAIRE

    Gocev, Zivko; Krstev, Aleksandar; Krstev, Boris; Golomeova, Mirjana; Zendelska, Afrodita

    2015-01-01

    The increasing in the chalcopyrite copper Bucim mine are gone forward to renewed reagent regime, including and involving new reagents for increased recovery of copper and gold. The optimization and mathematical linear are good example for improvement of industrial recoveries in flotation circuit. Nevertheless, the choice between flotation and new leaching or bioleaching method are challenge for future. The optimization techniques, for matting the mathematical model and adequate...

  16. FEMUR SHAPE RECOVERY FROM VOLUMETRIC IMAGES USING 3-D DEFORMABLE MODELS

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A new scheme for femur shape recovery from volumetric images using deformable models was proposed. First, prior 3-D deformable femur models are created as templates using point distribution models technology. Second, active contour models are employed to segment the magnetic resonance imaging (MRI) volumetric images of the tibial and femoral joints and the deformable models are initialized based on the segmentation results. Finally, the objective function is minimized to give the optimal results constraining the surface of shapes.

  17. Modeling Reef Fish Biomass, Recovery Potential, and Management Priorities in the Western Indian Ocean

    Science.gov (United States)

    McClanahan, Timothy R.; Maina, Joseph M.; Graham, Nicholas A. J.; Jones, Kendall R.

    2016-01-01

    Fish biomass is a primary driver of coral reef ecosystem services and has high sensitivity to human disturbances, particularly fishing. Estimates of fish biomass, their spatial distribution, and recovery potential are important for evaluating reef status and crucial for setting management targets. Here we modeled fish biomass estimates across all reefs of the western Indian Ocean using key variables that predicted the empirical data collected from 337 sites. These variables were used to create biomass and recovery time maps to prioritize spatially explicit conservation actions. The resultant fish biomass map showed high variability ranging from ~15 to 2900 kg/ha, primarily driven by human populations, distance to markets, and fisheries management restrictions. Lastly, we assembled data based on the age of fisheries closures and showed that biomass takes ~ 25 years to recover to typical equilibrium values of ~1200 kg/ha. The recovery times to biomass levels for sustainable fishing yields, maximum diversity, and ecosystem stability or conservation targets once fishing is suspended was modeled to estimate temporal costs of restrictions. The mean time to recovery for the whole region to the conservation target was 8.1(± 3SD) years, while recovery to sustainable fishing thresholds was between 0.5 and 4 years, but with high spatial variation. Recovery prioritization scenario models included one where local governance prioritized recovery of degraded reefs and two that prioritized minimizing recovery time, where countries either operated independently or collaborated. The regional collaboration scenario selected remote areas for conservation with uneven national responsibilities and spatial coverage, which could undermine collaboration. There is the potential to achieve sustainable fisheries within a decade by promoting these pathways according to their social-ecological suitability. PMID:27149673

  18. Recovery of time-dependent volatility in option pricing model

    Science.gov (United States)

    Deng, Zui-Cha; Hon, Y. C.; Isakov, V.

    2016-11-01

    In this paper we investigate an inverse problem of determining the time-dependent volatility from observed market prices of options with different strikes. Due to the non linearity and sparsity of observations, an analytical solution to the problem is generally not available. Numerical approximation is also difficult to obtain using most of the existing numerical algorithms. Based on our recent theoretical results, we apply the linearisation technique to convert the problem into an inverse source problem from which recovery of the unknown volatility function can be achieved. Two kinds of strategies, namely, the integral equation method and the Landweber iterations, are adopted to obtain the stable numerical solution to the inverse problem. Both theoretical analysis and numerical examples confirm that the proposed approaches are effective. The work described in this paper was partially supported by a grant from the Research Grant Council of the Hong Kong Special Administrative Region (Project No. CityU 101112) and grants from the NNSF of China (Nos. 11261029, 11461039), and NSF grants DMS 10-08902 and 15-14886 and by Emylou Keith and Betty Dutcher Distinguished Professorship at the Wichita State University (USA).

  19. How do strength and coordination recovery interact after stroke? A computational model for informing robotic training.

    Science.gov (United States)

    Norman, Sumner L; Lobo-Prat, Joan; Reinkensmeyer, David J

    2017-07-01

    Robotic devices can train strength, coordination, or a combination of both. If a robotic device focuses on coordination, what happens to strength recovery, and vice versa? Understanding this interaction could help optimize robotic training. We developed a computational neurorehabilitation model to gain insight into the interaction between strength and coordination recovery after stroke. In the model, the motor system recovers by optimizing the activity of residual corticospinal cells (focally connected, excitatory and inhibitory) and reticulospinal cells (diffusely connected and excitatory) to achieve a motor task. To do this, the model employs a reinforcement learning algorithm that uses stochastic search based on a reward signal produced by task execution. We simulated two tasks that require strength and coordination: a finger movement task and a bilateral wheelchair propulsion task. We varied the reward signal to value strength versus coordination, determined by a weighting factor. The model predicted a nonlinear relationship between strength and coordination recovery consistent with clinical data obtained for each task. The model also predicted that stroke can cause a competition between strength and coordination recovery, due to a scarcity of focal and inhibitory cells. These results provide a rationale for implementing robotic movement therapy that can adaptively alter the combination of force and coordination training to target desired components of motor recovery.

  20. Comparing population recovery after insecticide exposure for four aquatic invertebrate species using models of different complexity.

    Science.gov (United States)

    Baveco, J M Hans; Norman, Steve; Roessink, Ivo; Galic, Nika; Van den Brink, Paul J

    2014-07-01

    Population models, in particular individual-based models (IBMs), are becoming increasingly important in chemical risk assessment. They can be used to assess recovery of spatially structured populations after chemical exposure that varies in time and space. The authors used an IBM coupled to a toxicokinetic-toxicodynamic model, the threshold damage model (TDM), to assess recovery times for 4 aquatic organisms, after insecticide application, in a nonseasonal environment and in 3 spatial settings (pond, stream, and ditch). The species had different life histories (e.g., voltinism, reproductive capacity, mobility). Exposure was derived from a pesticide fate model, following standard European Union scenarios. The results of the IBM-TDM were compared with results from simpler models: one in which exposure was linked to effects by means of concentration-effect relationships (IBM-CE) and one in which the IBM was replaced by a nonspatial, logistic growth model (logistic). For the first, exposure was based on peak concentrations only; for the second, exposure was spatially averaged as well. By using comparisons between models of different complexity and species with different life histories, the authors obtained an understanding of the role spatial processes play in recovery and the conditions under which the full time-varying exposure needs to be considered. The logistic model, which is amenable to an analytic approach, provided additional insights into the sensitivity of recovery times to density dependence and spatial dimensions. © 2014 SETAC.

  1. Modeling of membrane processes for air revitalization and water recovery

    Science.gov (United States)

    Lange, Kevin E.; Foerg, Sandra L.; Dall-Bauman, Liese A.

    1992-01-01

    Gas-separation and reverse-osmosis membrane models are being developed in conjunction with membrane testing at NASA JSC. The completed gas-separation membrane model extracts effective component permeabilities from multicomponent test data, and predicts the effects of flow configuration, operating conditions, and membrane dimensions on module performance. Variable feed- and permeate-side pressures are considered. The model has been applied to test data for hollow-fiber membrane modules with simulated cabin-air feeds. Results are presented for a membrane designed for air drying applications. Extracted permeabilities are used to predict the effect of operating conditions on water enrichment in the permeate. A first-order reverse-osmosis model has been applied to test data for spiral wound membrane modules with a simulated hygiene water feed. The model estimates an effective local component rejection coefficient under pseudosteady-state conditions. Results are used to define requirements for a detailed reverse-osmosis model.

  2. Heat exchanger modeling and identification for control of waste heat recovery systems in diesel engines

    NARCIS (Netherlands)

    Feru, E.; Willems, F.P.T.; Rojer, C.; Jager, B. de; Steinbuch, M.

    2013-01-01

    To meet future CO2 emission targets, Waste Heat Recovery systems have recently attracted much attention for automotive applications, especially for long haul trucks. This paper focuses on the development of a dynamic counter-flow heat exchanger model for control purposes. The model captures the dyna

  3. Cognitive modelling of pilot errors and error recovery in flight management tasks

    NARCIS (Netherlands)

    Lüdtke, A.; Osterloh, J.P.; Mioch, T.; Rister, F.; Looije, R.

    2009-01-01

    This paper presents a cognitive modelling approach to predict pilot errors and error recovery during the interaction with aircraft cockpit systems. The model allows execution of flight procedures in a virtual simulation environment and production of simulation traces. We present traces for the inter

  4. Comparing population recovery after insecticide exposure for four aquatic invertebrate species using models of different complexity

    NARCIS (Netherlands)

    Baveco, H.; Norman, S.; Roessink, I.; Galic, N.G.; Brink, van den P.J.

    2014-01-01

    Population models, in particular individual-based models (IBMs), are becoming increasingly important in chemical risk assessment. They can be used to assess recovery of spatially structured populations after chemical exposure that varies in time and space. The authors used an IBM coupled to a

  5. Heat exchanger modeling and identification for control of waste heat recovery systems in diesel engines

    NARCIS (Netherlands)

    Feru, E.; Willems, F.P.T.; Rojer, C.; Jager, B. de; Steinbuch, M.

    2013-01-01

    To meet future CO2 emission targets, Waste Heat Recovery systems have recently attracted much attention for automotive applications, especially for long haul trucks. This paper focuses on the development of a dynamic counter-flow heat exchanger model for control purposes. The model captures the dyna

  6. Model Predictive Control of Offshore Power Stations With Waste Heat Recovery

    DEFF Research Database (Denmark)

    Pierobon, Leonardo; Chan, Richard; Li, Xiangan;

    2016-01-01

    The implementation of waste heat recovery units on oil and gas offshore platforms demands advances in both design methods and control systems. Model-based control algorithms can play an important role in the operation of offshore power stations. A novel regulator based on a linear model predictive...

  7. Modelling recovery from soil acidification in European forests under climate change

    NARCIS (Netherlands)

    Reinds, G.J.; Posch, M.; Leemans, R.

    2009-01-01

    A simple soil acidification model was applied to evaluate the effects of sulphur and nitrogen emission reductions on the recovery of acidified European forest soils. In addition we included the effects of climate change on soil solution chemistry, by modelling temperature effects on soil chemical

  8. Thermoelectric Generators for Automotive Waste Heat Recovery Systems Part I: Numerical Modeling and Baseline Model Analysis

    Science.gov (United States)

    Kumar, Sumeet; Heister, Stephen D.; Xu, Xianfan; Salvador, James R.; Meisner, Gregory P.

    2013-04-01

    A numerical model has been developed to simulate coupled thermal and electrical energy transfer processes in a thermoelectric generator (TEG) designed for automotive waste heat recovery systems. This model is capable of computing the overall heat transferred, the electrical power output, and the associated pressure drop for given inlet conditions of the exhaust gas and the available TEG volume. Multiple-filled skutterudites and conventional bismuth telluride are considered for thermoelectric modules (TEMs) for conversion of waste heat from exhaust into usable electrical power. Heat transfer between the hot exhaust gas and the hot side of the TEMs is enhanced with the use of a plate-fin heat exchanger integrated within the TEG and using liquid coolant on the cold side. The TEG is discretized along the exhaust flow direction using a finite-volume method. Each control volume is modeled as a thermal resistance network which consists of integrated submodels including a heat exchanger and a thermoelectric device. The pressure drop along the TEG is calculated using standard pressure loss correlations and viscous drag models. The model is validated to preserve global energy balances and is applied to analyze a prototype TEG with data provided by General Motors. Detailed results are provided for local and global heat transfer and electric power generation. In the companion paper, the model is then applied to consider various TEG topologies using skutterudite and bismuth telluride TEMs.

  9. A Predictive Model of Enhanced Oil Recovery by Infill Drilling and Its Application

    Institute of Scientific and Technical Information of China (English)

    Xu Jianhong; Cheng Linsong; Ma Lili

    2007-01-01

    Infill drilling is now recognized as a viable improved recovery process. However, the reliable prediction of incremental recovery by infill drilling cannot be readily and accurately determined by present techniques. This paper proposes a hybrid predictive model of stream tube simulation and numerical simulation by using the contemporary theory of fluid flow in porous media. The model calculates the geometries of stream tubes, remaining oil distribution and water cut at different development stages in the near future, and uses a three-dimensional simulation to track fluid movement in each stream tube slice. This will help reservoir engineers to determine the feasibility of infill drilling. This predictive model is used to forecast the degree of control of well pattern, the ultimate incremental recovery of infill wells within an inverted 5-spot case in an oilfield and the economic benefit is also analyzed.

  10. Modeling Donnan Dialysis Separation for Carboxylic Anion Recovery

    DEFF Research Database (Denmark)

    Prado Rubio, Oscar Andres; Møllerhøj, Martin; Jørgensen, Sten Bay

    2010-01-01

    dynamic model for transport of multiple ions through an anion exchange membrane is derived based on an irreversible thermodynamics approach. This model accounts for the convective transport of the dissociated and undissociated species in the channels with diffusion and migration across the boundary...... layers and membranes. Donnan equilibrium, flux continuity of the transported ions, the electroneutrality condition and Faraday's law are employed to describe the electrical potential and concentration discontinuities at the interfaces. The Nernst-Planck equation is used to model the ion transport though...

  11. Deformation-induced damage and recovery in model hydrogels - A molecular dynamics simulation

    Science.gov (United States)

    Zidek, Jan; Milchev, Andrey; Jancar, Josef; Vilgis, Thomas A.

    2016-09-01

    Using molecular dynamics simulation of a model hybrid cross-link hydrogel, we investigate the network damage evolution and the related structure transformations. We model the hydrogel structure as a network-connected assembly of crosslinked clusters whereby deformation-induced damage is considered along with network recovery. The two principal mechanisms involved in hydrogel recovery from deformation include segment hops of the building structure units (segments) between clusters and cluster shape modification. These mechanisms act either instantaneously, or with a certain time delay after the onset of deformation. By elucidating the conditions under which one of the mechanisms prevails, one may design hydrogel materials with a desired response to deformation.

  12. The recovery model: discourse ethics and the retrieval of the self.

    Science.gov (United States)

    Fardella, Joseph A

    2008-06-01

    The recovery model, as applied in mental health, is significant because it intends to foster a critical retrieval by the subject of herself as a self-determining agent of change. This paper will show that the recovery model represents an approach to caring for the self that is congruent with critical themes inherent in some forms of contemporary philosophy, particularly that of Michel Foucault and Jurgen Habermas. The paper will also consider the contribution that Habermas' discourse ethics could make towards the non-coercive, dialogical resolution of differences between clients and professionals.

  13. A survey on model based approaches for 2D and 3D visual human pose recovery.

    Science.gov (United States)

    Perez-Sala, Xavier; Escalera, Sergio; Angulo, Cecilio; Gonzàlez, Jordi

    2014-03-03

    Human Pose Recovery has been studied in the field of Computer Vision for the last 40 years. Several approaches have been reported, and significant improvements have been obtained in both data representation and model design. However, the problem of Human Pose Recovery in uncontrolled environments is far from being solved. In this paper, we define a general taxonomy to group model based approaches for Human Pose Recovery, which is composed of five main modules: appearance, viewpoint, spatial relations, temporal consistence, and behavior. Subsequently, a methodological comparison is performed following the proposed taxonomy, evaluating current SoA approaches in the aforementioned five group categories. As a result of this comparison, we discuss the main advantages and drawbacks of the reviewed literature.

  14. Independent air dehumidification with membrane-based total heat recovery: Modeling and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Liang, C.H.; Zhang, L.Z.; Pei, L.X. [Key Laboratory of Enhanced Heat Transfer and Energy Conservation of Education Ministry, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640 (China)

    2010-03-15

    Fresh air ventilation is helpful for the control of epidemic respiratory disease like Swine flu (H1N1). Fresh air dehumidification systems with energy recovery measures are the key equipments to realize this goal. As a solution, an independent air dehumidification system with membrane-based total heat recovery is proposed. A prototype is built in laboratory. A detailed model is proposed and a cell-by-cell simulation technique is used in simulation to evaluate performances. The results indicate that the model can predict the system accurately. The effects of varying operating conditions like air-flow rates, temperature, and air relative humidity on the air dehumidification rates, cooling powers, electric power consumption, and thermal coefficient of performance are evaluated. The prototype has a COP of 6.8 under nominal operating conditions with total heat recovery. The performance is rather robust to outside weather conditions with a membrane-based total heat exchanger. (author)

  15. A Unified Process Model of Syntactic and Semantic Error Recovery in Sentence Understanding

    CERN Document Server

    Holbrook, J K; Mahesh, K; Holbrook, Jennifer K.; Eiselt, Kurt P.; Mahesh, Kavi

    1994-01-01

    The development of models of human sentence processing has traditionally followed one of two paths. Either the model posited a sequence of processing modules, each with its own task-specific knowledge (e.g., syntax and semantics), or it posited a single processor utilizing different types of knowledge inextricably integrated into a monolithic knowledge base. Our previous work in modeling the sentence processor resulted in a model in which different processing modules used separate knowledge sources but operated in parallel to arrive at the interpretation of a sentence. One highlight of this model is that it offered an explanation of how the sentence processor might recover from an error in choosing the meaning of an ambiguous word. Recent experimental work by Laurie Stowe strongly suggests that the human sentence processor deals with syntactic error recovery using a mechanism very much like that proposed by our model of semantic error recovery. Another way to interpret Stowe's finding is this: the human sente...

  16. Functional recovery after facial nerve cable grafting in a rodent model.

    NARCIS (Netherlands)

    Hohman, M.H.; Kleiss, I.J.; Knox, C.J.; Weinberg, J.S.; Heaton, J.T.; Hadlock, T.A.

    2014-01-01

    IMPORTANCE: Cable grafting is widely considered to be the preferred alternative to primary repair of the injured facial nerve; however, quantitative comparison of the 2 techniques has not been previously undertaken in a rodent model. OBJECTIVE: To establish functional recovery parameters after inter

  17. Calculating the consequences of recovery, a European model for inhabited areas

    DEFF Research Database (Denmark)

    Charnock, T.W.; Jones, J.A.; Singer, L.N.

    2009-01-01

    The European Model for Inhabited Areas (ERMIN) was developed to allow a user to explore different recovery options following the contamination of an urban environment with radioactive material and to refine an appropriate strategy for the whole region affected. The input data include a description...

  18. Lactic Acid Recovery in Electro-Enhanced Dialysis: Modelling and Validation

    DEFF Research Database (Denmark)

    Prado Rubio, Oscar Andres; Jørgensen, Sten Bay; Jonsson, Gunnar Eigil

    2009-01-01

    and migration across the boundary layers and membranes. The model is validated for Donnan dialysis recovery of different monoprotic carboxylic acids. Simulations are used to evaluate the potential enhancement of lactate fluxes under current load conditions, referred as Electro-Enhanced Dialysis operation...

  19. Experimental validation of a dynamic waste heat recovery system model for control purposes

    NARCIS (Netherlands)

    Feru, E.; Kupper, F.; Rojer, C.; Seykens, X.L.J.; Scappin, F.; Willems, F.P.T.; Smits, J.; Jager, B. de; Steinbuch, M.

    2013-01-01

    This paper presents the identification and validation of a dynamic Waste Heat Recovery (WHR) system model. Driven by upcoming CO2 emission targets and increasing fuel costs, engine exhaust gas heat utilization has recently attracted much attention to improve fuel efficiency, especially for heavy-dut

  20. Application of Mathematical Modeling on Copper Recovery Optimization of Oxide Ores

    Science.gov (United States)

    Hoseinian, Fatemeh Sadat; Bahadori, Moein; Hashemzadeh, Mohsen; Rezai, Bahram; Soltani-Mohammadi, Saeed

    2017-10-01

    In this study, a mathematical modeling method was used to predict the optimum conditions of column leaching of copper oxide ore. Important parameters such as column height (m), particle sizes (m), acid rate (kg/ton) and leaching time (day) were studied and their impacts on copper recovery were investigated. Experiments were performed on samples with particle size distributions of -25.4 mm and -50.8 mm in six columns with the heights of 2 m, 4 m and 6 m. The results showed that the copper recovery has an inverse relation with column height and particle sizes, and direct relation with leaching time and acid rate. According to the results, the mathematical models based on the macro model predict the copper recovery based on operation conditions. The obtained values of determination coefficient (0.97), root mean square error (2.86) and relative error (0.089) testing datasets, showed the capability of the model in predicting the copper recovery.

  1. Experimental validation of a dynamic waste heat recovery system model for control purposes

    NARCIS (Netherlands)

    Feru, E.; Kupper, F.; Rojer, C.; Seykens, X.L.J.; Scappin, F.; Willems, F.P.T.; Smits, J.; Jager, B. de; Steinbuch, M.

    2013-01-01

    This paper presents the identification and validation of a dynamic Waste Heat Recovery (WHR) system model. Driven by upcoming CO2 emission targets and increasing fuel costs, engine exhaust gas heat utilization has recently attracted much attention to improve fuel efficiency, especially for

  2. Recovery Act. Development of a Model Energy Conservation Training Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-07-05

    The overall objective of this project was to develop an updated model Energy Conservation training program for stationary engineers. This revision to the IUOE National Training Fund’s existing Energy Conservation training curriculum is designed to enable stationary engineers to incorporate essential energy management into routine building operation and maintenance tasks. The curriculum uses a blended learning approach that includes classroom, hands-on, computer simulation and web-based training in addition to a portfolio requirement for a workplace-based learning application. The Energy Conservation training program goal is development of a workforce that can maintain new and existing commercial buildings at optimum energy performance levels. The grant start date was July 6, 2010 and the project continued through September 30, 2012, including a three month non-funded extension.

  3. A review of Bayesian state-space modelling of capture-recapture-recovery data.

    Science.gov (United States)

    King, Ruth

    2012-04-06

    Traditionally, state-space models are fitted to data where there is uncertainty in the observation or measurement of the system. State-space models are partitioned into an underlying system process describing the transitions of the true states of the system over time and the observation process linking the observations of the system to the true states. Open population capture-recapture-recovery data can be modelled in this framework by regarding the system process as the state of each individual observed within the study in terms of being alive or dead, and the observation process the recapture and/or recovery process. The traditional observation error of a state-space model is incorporated via the recapture/recovery probabilities being less than unity. The models can be fitted using a Bayesian data augmentation approach and in standard BUGS packages. Applying this state-space framework to such data permits additional complexities including individual heterogeneity to be fitted to the data at very little additional programming effort. We consider the efficiency of the state-space model fitting approach by considering a random effects model for capture-recapture data relating to dippers and compare different Bayesian model-fitting algorithms within WinBUGS.

  4. A review of Bayesian state-space modelling of capture–recapture–recovery data

    Science.gov (United States)

    King, Ruth

    2012-01-01

    Traditionally, state-space models are fitted to data where there is uncertainty in the observation or measurement of the system. State-space models are partitioned into an underlying system process describing the transitions of the true states of the system over time and the observation process linking the observations of the system to the true states. Open population capture–recapture–recovery data can be modelled in this framework by regarding the system process as the state of each individual observed within the study in terms of being alive or dead, and the observation process the recapture and/or recovery process. The traditional observation error of a state-space model is incorporated via the recapture/recovery probabilities being less than unity. The models can be fitted using a Bayesian data augmentation approach and in standard BUGS packages. Applying this state-space framework to such data permits additional complexities including individual heterogeneity to be fitted to the data at very little additional programming effort. We consider the efficiency of the state-space model fitting approach by considering a random effects model for capture–recapture data relating to dippers and compare different Bayesian model-fitting algorithms within WinBUGS. PMID:23565333

  5. Modeling the economic costs of disasters and recovery: analysis using a dynamic computable general equilibrium model

    Science.gov (United States)

    Xie, W.; Li, N.; Wu, J.-D.; Hao, X.-L.

    2014-04-01

    Disaster damages have negative effects on the economy, whereas reconstruction investment has positive effects. The aim of this study is to model economic causes of disasters and recovery involving the positive effects of reconstruction activities. Computable general equilibrium (CGE) model is a promising approach because it can incorporate these two kinds of shocks into a unified framework and furthermore avoid the double-counting problem. In order to factor both shocks into the CGE model, direct loss is set as the amount of capital stock reduced on the supply side of the economy; a portion of investments restores the capital stock in an existing period; an investment-driven dynamic model is formulated according to available reconstruction data, and the rest of a given country's saving is set as an endogenous variable to balance the fixed investment. The 2008 Wenchuan Earthquake is selected as a case study to illustrate the model, and three scenarios are constructed: S0 (no disaster occurs), S1 (disaster occurs with reconstruction investment) and S2 (disaster occurs without reconstruction investment). S0 is taken as business as usual, and the differences between S1 and S0 and that between S2 and S0 can be interpreted as economic losses including reconstruction and excluding reconstruction, respectively. The study showed that output from S1 is found to be closer to real data than that from S2. Economic loss under S2 is roughly 1.5 times that under S1. The gap in the economic aggregate between S1 and S0 is reduced to 3% at the end of government-led reconstruction activity, a level that should take another four years to achieve under S2.

  6. A mathematical modelling of imbibition phenomenon in inclined homogenous porous media during oil recovery process

    Directory of Open Access Journals (Sweden)

    Shreekant Pathak

    2016-09-01

    Full Text Available The approximate solution of imbibition phenomenon governed by non-linear partial differential equation is discussed in the present paper. Primary oil recovery process due to natural soil pressure, but in the secondary oil recovery process water flooding plays an important role. When water is injected in the injection well for recovering the reaming oil after primary oil recovery process, it comes to contact with the native oil and at that time the imbibition phenomenon occurs due to different viscosity. For the mathematical modelling, we consider the homogeneous porous medium and optimal homotopy analysis method has been used to solve the partial differential equation governed by it. The graphical representation of the solution is given by MATHEMATICA and physically interpreted.

  7. Computational rehabilitation of neglect: Using state-space models to understand the recovery mechanisms.

    Science.gov (United States)

    Sedda, Giulia; Ottonello, Marcella; Fiabane, Elena; Pistarini, Caterina; Sedda, Anna; Sanguineti, Vittorio

    2017-07-01

    Unilateral spatial neglect is a neuropsychological syndrome often observed in right hemisphere stroke patients. The symptoms differ from subject to subject. A few rehabilitation approaches, e.g. prism adaptation, have demonstrated some effect in reducing the symptoms, but the underlying mechanisms are still largely unclear. Recently, neural models have been proposed to qualitatively describe cortical lesions, the resulting neglect symptoms and the effects of treatment. However, these predictions are qualitative and cannot be used to compare different hypotheses or to interpret symptoms at individual subjects level. Here we propose a computational model of the trial-by-trial dynamics of training-induced recovery from neglect. Neglect is modelled in terms of an impaired internal representation of visual stimuli in the left hemispace. The model assumes that recovery is driven by the mismatch between defective representations of visual stimuli and the corresponding hand positions. The model reproduces the main observations of prism adaptation experiments. Using standard system identification techniques, we fitted the model to data from a rehabilitation trial based on a novel rehabilitation approach based on virtual reality, involving reaching movements within an adaptive environment. Our results suggest that the model can be used to interpret data from individual subjects and to formulate testable hypotheses on the mechanisms of recovery and directions for treatment.

  8. Dynamics and recovery of a sediment-exposed Chironomus riparius population: A modelling approach.

    Science.gov (United States)

    Diepens, Noël J; Beltman, Wim H J; Koelmans, Albert A; Van den Brink, Paul J; Baveco, Johannes M

    2016-06-01

    Models can be used to assess long-term risks of sediment-bound contaminants at the population level. However, these models usually lack the coupling between chemical fate in the sediment, toxicokinetic-toxicodynamic processes in individuals and propagation of individual-level effects to the population. We developed a population model that includes all these processes, and used it to assess the importance of chemical uptake routes on a Chironomus riparius population after pulsed exposure to the pesticide chlorpyrifos. We show that particle ingestion is an important additional exposure pathway affecting C. riparius population dynamics and recovery. Models ignoring particle ingestion underestimate the impact and the required recovery times, which implies that they underestimate risks of sediment-bound chemicals. Additional scenario studies showed the importance of selecting the biologically relevant sediment layer and showed population effects in the long term.

  9. Free-product plume distribution and recovery modeling prediction in a diesel-contaminated volcanic aquifer

    Science.gov (United States)

    Hernández-Espriú, Antonio; Martínez-Santos, Pedro; Sánchez-León, Emilio; Marín, Luis E.

    Light non-aqueous phase liquids (LNAPL) represent one of the most serious problems in aquifers contaminated with petroleum hydrocarbons liquids. To design an appropriate remediation strategy it is essential to understand the behavior of the plume. The aim of this paper is threefold: (1) to characterize the fluid distribution of an LNAPL plume detected in a volcanic low-conductivity aquifer (∼0.4 m/day from slug tests interpretation), (2) to simulate the recovery processes of the free-product contamination and (3) to evaluate the primary recovery efficiency of the following alternatives: skimming, dual-phase extraction, Bioslurping and multi-phase extraction wells. The API/Charbeneau analytical model was used to investigate the recovery feasibility based on the geological properties and hydrogeological conditions with a multi-phase (water, air, LNAPL) transport approach in the vadose zone. The modeling performed in this research, in terms of LNAPL distribution in the subsurface, show that oil saturation is 7% in the air-oil interface, with a maximum value of 70% in the capillary fringe. Equilibrium between water and LNAPL phases is reached at a depth of 1.80 m from the air-oil interface. On the other hand, the LNAPL recovery model results suggest a remarkable enhancement of the free-product recovery when simultaneous extra-phase extraction was simulated from wells, in addition to the LNAPL lens. Recovery efficiencies were 27%, 65%, 66% and 67% for skimming, dual-phase extraction, Bioslurping and multi-phase extraction, respectively. During a 3-year simulation, skimmer wells and multi-phase extraction showed the lowest and highest LNAPL recovery rates, with expected values from 207 to 163 and 2305 to 707 l-LNAPL/day, respectively. At a field level we are proposing a well distribution arrangement that alternates pairs of dual-phase well-Bioslurping well. This not only improves the recovery of the free-product plume, but also pumps the dissolve plume and enhances in

  10. Black liquor combustion validated recovery boiler modeling, five-year report

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1996-08-01

    The objective of this project was to develop a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The project originated in October 1990 and was scheduled to run for four years. At that time, there was considerable emphasis on developing accurate predictions of the physical carryover of macroscopic particles of partially burnt black liquor and smelt droplets out of the furnace, since this was seen as the main cause of boiler plugging. This placed a major emphasis on gas flow patterns within the furnace and on the mass loss rates and swelling and shrinking rates of burning black liquor drops. As work proceeded on developing the recovery boiler furnace model, it became apparent that some recovery boilers encounter serious plugging problems even when physical carryover was minimal. After the original four-year period was completed, the project was extended to address this issue. The objective of the extended project was to improve the utility of the models by including the black liquor chemistry relevant to air emissions predictions and aerosol formation, and by developing the knowledge base and computational tools to relate furnace model outputs to fouling and plugging of the convective sections of the boilers. The work done to date includes CFD model development and validation, acquisition of information on black liquor combustion fundamentals and development of improved burning models, char bed model development, and model application and simplification.

  11. Modelling of an industrial NGL-Recovery unit considering environmental and economic impacts

    Energy Technology Data Exchange (ETDEWEB)

    Sharratt, P. N.; Hernandez-Enriquez, A.; Flores-Tlacuahuac, A.

    2009-07-01

    In this work, an integrated model is presented that identifies key areas in the operation of a cryogenic NGL-recovery unit. This methodology sets out to provide deep understanding of various interrelationship across multiple plant operating factors including reliability, which could be essential for substantial improvement of process performance. The integrated model has been developed to predict the economic and environmental impacts of a real cryogenic unit (600 MMCUF/D) during normal operation, and has been built in Aspen TM. (Author)

  12. Process Model of A Fusion Fuel Recovery System for a Direct Drive IFE Power Reactor

    Science.gov (United States)

    Natta, Saswathi; Aristova, Maria; Gentile, Charles

    2008-11-01

    A task has been initiated to develop a detailed representative model for the fuel recovery system (FRS) in the prospective direct drive inertial fusion energy (IFE) reactor. As part of the conceptual design phase of the project, a chemical process model is developed in order to observe the interaction of system components. This process model is developed using FEMLAB Multiphysics software with the corresponding chemical engineering module (CEM). Initially, the reactants, system structure, and processes are defined using known chemical species of the target chamber exhaust. Each step within the Fuel recovery system is modeled compartmentally and then merged to form the closed loop fuel recovery system. The output, which includes physical properties and chemical content of the products, is analyzed after each step of the system to determine the most efficient and productive system parameters. This will serve to attenuate possible bottlenecks in the system. This modeling evaluation is instrumental in optimizing and closing the fusion fuel cycle in a direct drive IFE power reactor. The results of the modeling are presented in this paper.

  13. Acidification and recovery at mountain lakes in Central Alps assessed by the MAGIC model

    Directory of Open Access Journals (Sweden)

    Michela ROGORA

    2004-02-01

    Full Text Available The dynamic model MAGIC was calibrated and applied to 84 lakes in Central Alps to predict the response of water chemistry to different scenarios of atmospheric deposition of S and N compounds. Selected lakes were representative of a wide range of chemical characteristics and of sensitivity to acidification. The most sensitive lakes have already shown in the latest years signs of recovery in terms of pH and ANC. The model well captured the main trends in lake chemical data. According to the model forecast, recovery at sensitive lakes will continue in the next decades under the hypothesis of a further decrease of acidic input from the atmosphere. Results clearly demonstrated the benefits of achieving the emission reductions in both S and N compounds agreed under the Gothenburg Protocol. Nevertheless, besides the achieved reduction of SO4 2- deposition from the peak levels of the 80s, also N deposition should be reduced in the near future to protect alpine lakes from further acidification. The condition of lake catchments with regard to N saturation will probably be the dominant factor driving recovery extent. Beside atmospheric deposition, other factors proved to be important in determining long-term changes in surface water chemistry. Climate warming in particular affects weathering processes in lake catchments and dynamics of the N cycle. Including other factors specific to the alpine area, such as dust deposition and climate change, may improve the fit of experimental data by the model and the reliability of model forecast.

  14. Modeling early recovery of physical function following hip and knee arthroplasty

    Directory of Open Access Journals (Sweden)

    Stratford Paul W

    2006-12-01

    Full Text Available Abstract Background Information on early recovery after arthroplasty is needed to help benchmark progress and make appropriate decisions concerning patient rehabilitation needs. The purpose of this study was to model early recovery of physical function in patients undergoing total hip (THA and knee (TKA arthroplasty, using physical performance and self-report measures. Methods A sample of convenience of 152 subjects completed testing, of which 69 (mean age: 66.77 ± 8.23 years underwent THA and 83 (mean age: 60.25 ± 11.19 years TKA. Postoperatively, patients were treated using standardized care pathways and rehabilitation protocols. Using a repeated measures design, patients were assessed at multiple time points over the first four postoperative months. Outcome measures included the Lower Extremity Function Scale (LEFS, the physical function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC PF, the 6 minute walk test (6 MWT, timed up and go test (TUG and a timed stair test (ST. Average recovery curves for each of the measures were characterized using hierarchical linear modeling. Predictors of recovery were sequentially modeled after validation of the basic developmental models. Results Slopes of recovery were greater in the first 6 to 9 weeks with a second-degree polynomial growth term (weeks squared providing a reasonable fit for the data over the study interval. Different patterns of recovery were observed between the self-report measures of physical function and the performance measures. In contrast to the models for the WOMAC PF and the LEFS, site of arthroplasty was a significant predictor (p = 0.001 in all of the physical performance measure models with the patients post TKA initially demonstrating higher function. Site of arthroplasty (p = 0.025 also predicted the rate of change for patients post THA and between 9 to 11 weeks after surgery, the THA group surpassed the function of the patients post TKA

  15. Black liquor combustion validated recovery boiler modeling: Final year report. Volume 4 (Appendix IV)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1998-08-01

    This project was initiated in October 1990, with the objective of developing and validating a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The key tasks to be accomplished were as follows: (1) Complete the development of enhanced furnace models that have the capability to accurately predict carryover, emissions behavior, dust concentrations, gas temperatures, and wall heat fluxes. (2) Validate the enhanced furnace models, so that users can have confidence in the predicted results. (3) Obtain fundamental information on aerosol formation, deposition, and hardening so as to develop the knowledge base needed to relate furnace model outputs to plugging and fouling in the convective sections of the boiler. (4) Facilitate the transfer of codes, black liquid submodels, and fundamental knowledge to the US kraft pulp industry. Volume 4 contains the following appendix sections: Radiative heat transfer properties for black liquor combustion -- Facilities and techniques and Spectral absorbance and emittance data; and Radiate heat transfer determination of the optical constants of ash samples from kraft recovery boilers -- Calculation procedure; Computation program; Density determination; Particle diameter determination; Optical constant data; and Uncertainty analysis.

  16. Optical coherence tomography and hyperspectral imaging of vascular recovery in a model of peripheral arterial disease

    Science.gov (United States)

    Poole, Kristin M.; Sit, Wesley W.; Tucker-Schwartz, Jason M.; Duvall, Craig L.; Skala, Melissa C.

    2013-03-01

    Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb ischemia (HLI) model is the most commonly used system for studying the mechanisms of collateral vessel formation and for testing new PAD therapies, but there is a lack of techniques for acquiring physiologically-relevant, quantitative data intravitally in this model. In this work, non-invasive, quantitative optical imaging techniques were applied to the mouse HLI model over a time course. Optical coherence tomography (OCT) imaged changes in blood flow (Doppler OCT) and microvessel morphology (speckle variance OCT) through the skin of haired mice with high resolution. Hyperspectral imaging was also used to quantify blood oxygenation. In ischemic limbs, blood oxygenation in the footpad was substantially reduced after induction of ischemia followed by complete recovery by three weeks, consistent with standard measures. Three dimensional images of the vasculature distal to vessel occlusion acquired with speckle variance OCT revealed changes in OCT flow signal and vessel morphology. Taken together, OCT and hyperspectral imaging enable intravital acquisition of both functional and morphological data which fill critical gaps in understanding structure-function relationships that contribute to recovery in the mouse HLI model. Therefore, these optical imaging methods hold promise as tools for studying the mechanisms of vascular recovery and evaluating novel therapeutic treatments in preclinical studies.

  17. An extended model for ultrasonic-based enhanced oil recovery with experimental validation.

    Science.gov (United States)

    Mohsin, Mohammed; Meribout, Mahmoud

    2015-03-01

    This paper suggests a new ultrasonic-based enhanced oil recovery (EOR) model for application in oil field reservoirs. The model is modular and consists of an acoustic module and a heat transfer module, where the heat distribution is updated when the temperature rise exceeds 1 °C. The model also considers the main EOR parameters which includes both the geophysical (i.e., porosity, permeability, temperature rise, and fluid viscosity) and acoustical (e.g., acoustic penetration and pressure distribution in various fluids and mediums) properties of the wells. Extended experiments were performed using powerful ultrasonic waves which were applied for different kind of oils & oil saturated core samples. The corresponding results showed a good matching with those obtained from simulations, validating the suggested model to some extent. Hence, a good recovery rate of around 88.2% of original oil in place (OOIP) was obtained after 30 min of continuous generation of ultrasonic waves. This leads to consider the ultrasonic-based EOR as another tangible solution for EOR. This claim is supported further by considering several injection wells where the simulation results indicate that with four (4) injection wells; the recovery rate may increase up-to 96.7% of OOIP. This leads to claim the high potential of ultrasonic-based EOR as compared to the conventional methods. Following this study, the paper also proposes a large scale ultrasonic-based EOR hardware system for installation in oil fields.

  18. Vagus nerve stimulation delivered during motor rehabilitation improves recovery in a rat model of stroke.

    Science.gov (United States)

    Khodaparast, Navid; Hays, Seth A; Sloan, Andrew M; Fayyaz, Tabbassum; Hulsey, Daniel R; Rennaker, Robert L; Kilgard, Michael P

    2014-09-01

    Neural plasticity is widely believed to support functional recovery following brain damage. Vagus nerve stimulation paired with different forelimb movements causes long-lasting map plasticity in rat primary motor cortex that is specific to the paired movement. We tested the hypothesis that repeatedly pairing vagus nerve stimulation with upper forelimb movements would improve recovery of motor function in a rat model of stroke. Rats were separated into 3 groups: vagus nerve stimulation during rehabilitation (rehab), vagus nerve stimulation after rehab, and rehab alone. Animals underwent 4 training stages: shaping (motor skill learning), prelesion training, postlesion training, and therapeutic training. Rats were given a unilateral ischemic lesion within motor cortex and implanted with a left vagus nerve cuff. Animals were allowed 1 week of recovery before postlesion baseline training. During the therapeutic training stage, rats received vagus nerve stimulation paired with each successful trial. All 17 trained rats demonstrated significant contralateral forelimb impairment when performing a bradykinesia assessment task. Forelimb function was recovered completely to prelesion levels when vagus nerve stimulation was delivered during rehab training. Alternatively, intensive rehab training alone (without stimulation) failed to restore function to prelesion levels. Delivering the same amount of stimulation after rehab training did not yield improvements compared with rehab alone. These results demonstrate that vagus nerve stimulation repeatedly paired with successful forelimb movements can improve recovery after motor cortex ischemia and may be a viable option for stroke rehabilitation.

  19. Chitooligosaccharide Inhibits Scar Formation and Enhances Functional Recovery in a Mouse Model of Sciatic Nerve Injury.

    Science.gov (United States)

    Hou, Hongping; Zhang, Lihai; Ye, Zuguang; Li, Jianrong; Lian, Zijian; Chen, Chao; He, Rong; Peng, Bo; Xu, Qihua; Zhang, Guangping; Gan, Wenbiao; Tang, Peifu

    2016-05-01

    Chitooligosaccharide (COS) has been shown to induce fibroblast apoptosis, indicating that it could be used as a material to inhibit scar formation. In the present study, we used a mouse model of sciatic nerve injury (SNI) to determine the role of COS in scar inhibition and functional recovery. The animals were divided into three groups: SNI, SNI + vehicle, and SNI + COS group. We performed a series of functional and histological examinations at ctrl, 0 min, 14 days, and 42 days, including behavioral recovery, percentage of regenerating axons, degree of scar formation, vascular changes, type I and type III collagen ratio, and percentage of demyelinated axons. The SNI + COS group exhibited better recovery of sensory and motor function and less scar formation. Two-photon microscopy showed that the percentage of regenerating axons was highest in the SNI + COS group at 14 and 42 days. Our results suggested that COS can inhibit scar formation and enhance functional recovery by inducing fibroblast death, altering the proportion of different vascular diameters, changing the ratio of type I/type III collagen, and reducing the percentage of demyelinated axons. COS might be a useful drug in the treatment of SNI to reduce scar formation, but additional research is required to clarify the relevant molecular pathways.

  20. Fast implementation for compressive recovery of highly accelerated cardiac cine MRI using the balanced sparse model.

    Science.gov (United States)

    Ting, Samuel T; Ahmad, Rizwan; Jin, Ning; Craft, Jason; Serafim da Silveira, Juliana; Xue, Hui; Simonetti, Orlando P

    2017-04-01

    Sparsity-promoting regularizers can enable stable recovery of highly undersampled magnetic resonance imaging (MRI), promising to improve the clinical utility of challenging applications. However, lengthy computation time limits the clinical use of these methods, especially for dynamic MRI with its large corpus of spatiotemporal data. Here, we present a holistic framework that utilizes the balanced sparse model for compressive sensing and parallel computing to reduce the computation time of cardiac MRI recovery methods. We propose a fast, iterative soft-thresholding method to solve the resulting ℓ1-regularized least squares problem. In addition, our approach utilizes a parallel computing environment that is fully integrated with the MRI acquisition software. The methodology is applied to two formulations of the multichannel MRI problem: image-based recovery and k-space-based recovery. Using measured MRI data, we show that, for a 224 × 144 image series with 48 frames, the proposed k-space-based approach achieves a mean reconstruction time of 2.35 min, a 24-fold improvement compared a reconstruction time of 55.5 min for the nonlinear conjugate gradient method, and the proposed image-based approach achieves a mean reconstruction time of 13.8 s. Our approach can be utilized to achieve fast reconstruction of large MRI datasets, thereby increasing the clinical utility of reconstruction techniques based on compressed sensing. Magn Reson Med 77:1505-1515, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  1. A STREAMLINE-BASED PREDICTIVE MODEL FOR ENHANCED-OIL-RECOVERY POTENTIALITY

    Institute of Scientific and Technical Information of China (English)

    HOU Jian; ZHANG Shun-kang; DU Qing-jun; LI Yu-bin

    2008-01-01

    A pseudo-three-dimensional model of potentiality prediction is proposed for enhanced oil recovery, based on the streamline method described in this article. The potential distribution of the flow through a porous medium under a complicated boundary condition is solved with the boundary element method. Furthermore, the method for tracing streamlines between injection wells and producing wells is presented. Based on the results, a numerical solution can be obtained by solving the seepage problem of the stream-tube with consideration of different methods of Enhanced Oil Recovery(EOR). The advantage of the method given in this article is that it can obtain dynamic calculation with different well patterns of any shape by easily considering different physicochemical phenomena having less calculation time and good stability. Based on the uniform theory basis-streamline method, different models, including CO2 miscible flooding, polymer flooding, alkaline/surfactant/polymer flooding and microbial flooding, are established in this article.

  2. Physical modeling of a sidetrack horizontal wellproduction to improve oil recovery

    Institute of Scientific and Technical Information of China (English)

    王家禄; 江如意

    2002-01-01

    The scaling criteria of physical modeling of a horizontal well production are discussed. A scaled experimental model was designed and realized. The experiments of a sidetrack horizontal well production have been carried out in the system, and the production curve variation is analyzed. The oil recovery of a sidetrack horizontal well production is compared with that of a vertical well, and the effect of factors such as sidetrack drilling time, water driving rate and the length of horizontal section on oil recovery are discussed. The production of a horizontal well changed both the fluid flow direction and pressure distribution in the reservoir; as a result the remaining oil in the dead oil region is recovered, and the ultimate oil output is raised.

  3. Elucidating the role of recovery experiences in the job demands-resources model.

    Science.gov (United States)

    Moreno-Jiménez, Bernardo; Rodríguez-Muñoz, Alfredo; Sanz-Vergel, Ana Isabel; Garrosa, Eva

    2012-07-01

    Based on the Job Demands-Resources (JD-R) model, the current study examined the moderating role of recovery experiences (i.e., psychological detachment from work, relaxation, mastery experiences, and control over leisure time) on the relationship between one job demand (i.e., role conflict) and work- and health-related outcomes. Results from our sample of 990 employees from Spain showed that psychological detachment from work and relaxation buffered the negative impact of role conflict on some of the proposed outcomes. Contrary to our expectations, we did not find significant results for mastery and control regarding moderating effects. Overall, findings suggest a differential pattern of the recovery experiences in the health impairment process proposed by the JD-R model.

  4. Modeling of waste heat recovery by looped water-in-steel heat pipes

    Energy Technology Data Exchange (ETDEWEB)

    Akyurt, M.; Lamfon, N.J.; Najjar, Y.S.H.; Habeebullah, M.H.; Alp, T.Y. [King Abdulaziz Univ., Jeddah (Saudi Arabia). College of Engineering

    1995-08-01

    Modeling and simulation of a water-in-steel heat pipe heat recovery system is undertaken in this paper. The heat recovery system consists of a looped two-phase thermosyphon that receives heat from the stack of a gas turbine engine and delivers it to the generator of an NH{sub 3}-H{sub 2}O absorption chiller. Variations in the operating temperature as well as evaporator geometry are investigated, and the consequences on system effectiveness are studied. It is concluded that the model for the water-in-steel looped thermosyphon overcomes drawbacks of the water-in-copper thermosyphon, and that the steel system is simpler in design, lower in cost, and more competent in performance. (author)

  5. Can a first-order exponential decay model fit heart rate recovery after resistance exercise?

    Science.gov (United States)

    Bartels-Ferreira, Rhenan; de Sousa, Élder D; Trevizani, Gabriela A; Silva, Lilian P; Nakamura, Fábio Y; Forjaz, Cláudia L M; Lima, Jorge Roberto P; Peçanha, Tiago

    2015-03-01

    The time-constant of postexercise heart rate recovery (HRRτ ) obtained by fitting heart rate decay curve by a first-order exponential fitting has being used to assess cardiac autonomic recovery after endurance exercise. The feasibility of this model was not tested after resistance exercise (RE). The aim of this study was to test the goodness of fit of the first-order exponential decay model to fit heart rate recovery (HRR) after RE. Ten healthy subjects participated in the study. The experimental sessions occurred in two separated days and consisted of performance of 1 set of 10 repetitions at 50% or 80% of the load achieved on the one-repetition maximum test [low-intensity (LI) and high-intensity (HI) sessions, respectively]. Heart rate (HR) was continuously registered before and during exercise and also for 10 min of recovery. A monoexponential equation was used to fit the HRR curve during the postexercise period using different time windows (i.e. 30, 60, 90, … 600 s). For each time window, (i) HRRτ was calculated and (ii) variation of HR explained by the model (R(2) goodness of fit index) was assessed. The HRRτ showed stabilization from 360 and 420 s on LI and HI, respectively. Acceptable R(2) values were observed from the 360 s on LI (R(2) > 0.65) and at all tested time windows on HI (R(2) > 0.75). In conclusion, this study showed that using a minimum length of monitoring (~420 s) HRR after RE can be adequately modelled by a first-order exponential fitting. © 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  6. A comparison of two coaching approaches to enhance implementation of a recovery-oriented service model.

    Science.gov (United States)

    Deane, Frank P; Andresen, Retta; Crowe, Trevor P; Oades, Lindsay G; Ciarrochi, Joseph; Williams, Virginia

    2014-09-01

    Moving to recovery-oriented service provision in mental health may entail retraining existing staff, as well as training new staff. This represents a substantial burden on organisations, particularly since transfer of training into practice is often poor. Follow-up supervision and/or coaching have been found to improve the implementation and sustainment of new approaches. We compared the effect of two coaching conditions, skills-based and transformational coaching, on the implementation of a recovery-oriented model following training. Training followed by coaching led to significant sustained improvements in the quality of care planning in accordance with the new model over the 12-month study period. No interaction effect was observed between the two conditions. However, post hoc analyses suggest that transformational coaching warrants further exploration. The results support the provision of supervision in the form of coaching in the implementation of a recovery-oriented service model, and suggest the need to better elucidate the mechanisms within different coaching approaches that might contribute to improved care.

  7. Multi-view 3D human pose estimation combining single-frame recovery, temporal integration and model adaptation

    NARCIS (Netherlands)

    Hofmann, K.M.; Gavrilla, D.M.

    2009-01-01

    We present a system for the estimation of unconstrained 3D human upper body movement from multiple cameras. Its main novelty lies in the integration of three components: single frame pose recovery, temporal integration and model adaptation. Single frame pose recovery consists of a hypothesis generat

  8. Modeling and Control of a Parallel Waste Heat Recovery System for Euro-VI Heavy-Duty Diesel Engines

    NARCIS (Netherlands)

    Feru, E.; Willems, F.P.T.; Jager, B. de; Steinbuch, M.

    2014-01-01

    This paper presents the modeling and control of a waste heat recovery system for a Euro-VI heavy-duty truck engine. The considered waste heat recovery system consists of two parallel evaporators with expander and pumps mechanically coupled to the engine crankshaft. Compared to previous work, the

  9. Multi-view 3D human pose estimation combining single-frame recovery, temporal integration and model adaptation

    NARCIS (Netherlands)

    Hofmann, K.M.; Gavrila, D.M.

    2009-01-01

    We present a system for the estimation of unconstrained 3D human upper body movement from multiple cameras. Its main novelty lies in the integration of three components: single-frame pose recovery, temporal integration and model adaptation. Single-frame pose recovery consists of a hypothesis generat

  10. Modeling and Control of a Parallel Waste Heat Recovery System for Euro-VI Heavy-Duty Diesel Engines

    NARCIS (Netherlands)

    Feru, E.; Willems, F.P.T.; Jager, B. de; Steinbuch, M.

    2014-01-01

    This paper presents the modeling and control of a waste heat recovery system for a Euro-VI heavy-duty truck engine. The considered waste heat recovery system consists of two parallel evaporators with expander and pumps mechanically coupled to the engine crankshaft. Compared to previous work, the was

  11. Recovery of acidified mountain lakes in Norway as predicted by the MAGIC model

    Directory of Open Access Journals (Sweden)

    Bernard J. COSBY

    2004-02-01

    Full Text Available As part of the EU project EMERGE the biogeochemical model MAGIC was used to reconstruct acidification history and predict future recovery for mountain lakes in two regions of Norway. Central Norway (19 lakes receives low levels of acid deposition, most of the lakes have undergone only minor amounts of acidification, and all are predicted to recover in the future. Central Norway thus represents a reference area for more polluted regions in southern Norway and elsewhere in Europe. Southern Norway (23 lakes, on the other hand, receives higher levels of acid deposition, nearly all the studied lakes were acidified and had lost fish populations, and although some recovery has occurred during the period 1980-2000 and additional recovery is predicted for the next decades, the model simulations indicated that the majority of the lakes will not achieve water quality sufficient to support trout populations. Uncertainties in these predictions include possible future N saturation and the exacerbating effects of climate change. The mountain lakes of southern Norway are among the most sensitive in Europe. For southern Norway additional measures such as stricter controls of emissions of air pollutants will be required to obtain satisfactory water quality in the future.

  12. Modeling of Recovery Profiles in Mentally Disabled and Intact Patients after Sevoflurane Anesthesia; A Pharmacodynamic Analysis

    Science.gov (United States)

    Shin, Teo Jeon; Noh, Gyu-Jeong; Koo, Yong-Seo

    2014-01-01

    Purpose Mentally disabled patients show different recovery profiles compared to normal patients after general anesthesia. However, the relationship of dose-recovery profiles of mentally disabled patients has never been compared to that of normal patients. Materials and Methods Twenty patients (10 mentally disabled patients and 10 mentally intact patients) scheduled to dental surgery under general anesthesia was recruited. Sevoflurane was administered to maintain anesthesia during dental treatment. At the end of the surgery, sevoflurane was discontinued. End-tidal sevoflurane and recovery of consciousness (ROC) were recorded after sevoflurane discontinuation. The pharmacodynamic relation between the probability of ROC and end-tidal sevoflurane concentration was analyzed using NONMEM software (version VII). Results End-tidal sevoflurane concentration associated with 50% probability of ROC (C50) and γ value were lower in the mentally disabled patients (C50=0.37 vol %, γ=16.5 in mentally intact patients, C50=0.19 vol %, γ=4.58 in mentally disabled patients). Mentality was a significant covariate of C50 for ROC and γ value to pharmacodynamic model. Conclusion A sigmoid Emanx model explains the pharmacodynamic relationship between end-tidal sevoflurane concentration and ROC. Mentally disabled patients may recover slower from anesthesia at lower sevoflurane concentration at ROC an compared to normal patients. PMID:25323901

  13. Reactive Transport Modeling of Microbe-mediated Fe (II) Oxidation for Enhanced Oil Recovery

    Science.gov (United States)

    Surasani, V.; Li, L.

    2011-12-01

    Microbially Enhanced Oil Recovery (MEOR) aims to improve the recovery of entrapped heavy oil in depleted reservoirs using microbe-based technology. Reservoir ecosystems often contain diverse microbial communities those can interact with subsurface fluids and minerals through a network of nutrients and energy fluxes. Microbe-mediated reactions products include gases, biosurfactants, biopolymers those can alter the properties of oil and interfacial interactions between oil, brine, and rocks. In addition, the produced biomass and mineral precipitates can change the reservoir permeability profile and increase sweeping efficiency. Under subsurface conditions, the injection of nitrate and Fe (II) as the electron acceptor and donor allows bacteria to grow. The reaction products include minerals such as Fe(OH)3 and nitrogen containing gases. These reaction products can have large impact on oil and reservoir properties and can enhance the recovery of trapped oil. This work aims to understand the Fe(II) oxidation by nitrate under conditions relevant to MEOR. Reactive transport modeling is used to simulate the fluid flow, transport, and reactions involved in this process. Here we developed a complex reactive network for microbial mediated nitrate-dependent Fe (II) oxidation that involves both thermodynamic controlled aqueous reactions and kinetic controlled Fe (II) mineral reaction. Reactive transport modeling is used to understand and quantify the coupling between flow, transport, and reaction processes. Our results identify key parameter controls those are important for the alteration of permeability profile under field conditions.

  14. [Skin and tissue bank: Operational model for the recovery and preservation of tissues and skin allografts].

    Science.gov (United States)

    Martínez-Flores, Francisco; Sandoval-Zamora, Hugo; Machuca-Rodriguez, Catalina; Barrera-López, Araceli; García-Cavazos, Ricardo; Madinaveitia-Villanueva, Juan Antonio

    2016-01-01

    Tissue storage is a medical process that is in the regulation and homogenisation phase in the scientific world. The international standards require the need to ensure safety and efficacy of human allografts such as skin and other tissues. The activities of skin and tissues banks currently involve their recovery, processing, storage and distribution, which are positively correlated with technological and scientific advances present in current biomedical sciences. A description is presented of the operational model of Skin and Tissue Bank at INR as successful case for procurement, recovery and preservation of skin and tissues for therapeutic uses, with high safety and biological quality. The essential and standard guidelines are presented as keystones for a tissue recovery program based on scientific evidence, and within an ethical and legal framework, as well as to propose a model for complete overview of the donation of tissues and organ programs in Mexico. Finally, it concludes with essential proposals for improving the efficacy of transplantation of organs and tissue programs. Copyright © 2015 Academia Mexicana de Cirugía A.C. Published by Masson Doyma México S.A. All rights reserved.

  15. Cellular recovery from electroporation using synchronisation modulation as a rescue model for electrically injured cells.

    Science.gov (United States)

    Dando, Robin; Chen, Wei

    2008-12-01

    Electroporation of the plasma membrane resulting in a decrement in transmembrane potential is offered as a model in the study of the rescuing effects of the synchronisation modulation technique by electrically activating sodium potassium adenosine triphosphatase. Living cells were first electrically damaged by a pulsed intensive electric field, resulting in cell membrane electroporation, ion leakages and membrane potential depolarisation. Their recovery rate in natural conditions was compared with that of cells in a synchronisation modulation electric field. Fluorescence readings were taken using confocal microscopy and a potentiometric dye. Significantly more rapid recovery was observed after synchronisation modulation, with cell membranes actually polarised to levels higher than the original resting potential, a feature never seen in naturally recovering cells.

  16. Modeling community integration in workers with delayed recovery from mild traumatic brain injury

    DEFF Research Database (Denmark)

    Mollayeva, T.; Shapiro, C. M.; Mollayeva, S.

    2015-01-01

    Background: Delayed recovery in persons after mild traumatic brain injury (mTBI) is poorly understood. Community integration (CI) is endorsed by persons with neurological disorders as an important outcome. We aimed to describe CI and its associated factors in insured Ontario workers with delayed...... recovery following mTBI. Methods: A cross-sectional study of insured workers in the chronic phase following mTBI was performed at a rehabilitation hospital in Ontario, Canada. Sociodemographic, occupational, injury-related, clinical, and claim-related data were collected from self-reports, medical...... assessments, and insurers' referral files. Community Integration Questionnaire (CIQ) scores were compared using analysis of variance or Spearman's correlation tests. Stepwise multivariable linear regression models were used to evaluate the associations with CI. Results: Ninety-four workers with mTBI (45...

  17. Trust recovery model of Ad Hoc network based on identity authentication scheme

    Science.gov (United States)

    Liu, Jie; Huan, Shuiyuan

    2017-05-01

    Mobile Ad Hoc network trust model is widely used to solve mobile Ad Hoc network security issues. Aiming at the problem of reducing the network availability caused by the processing of malicious nodes and selfish nodes in mobile Ad Hoc network routing based on trust model, an authentication mechanism based on identity authentication mobile Ad Hoc network is proposed, which uses identity authentication to identify malicious nodes, And trust the recovery of selfish nodes in order to achieve the purpose of reducing network congestion and improving network quality. The simulation results show that the implementation of the mechanism can effectively improve the network availability and security.

  18. Modelling acidification, recovery and target loads for headwater catchments in Nova Scotia, Canada

    Directory of Open Access Journals (Sweden)

    C. J. Whitfield

    2007-01-01

    Full Text Available The response of twenty acid-sensitive headwater catchments in Nova Scotia to acidic deposition was investigated for the period 1850–2100 using a dynamic hydrochemical model (MAGIC: Model of Acidification of Groundwater in Catchments. To ensure robust model simulation, MAGIC was calibrated to the long-term chemical trend in annual lake observations (13–20 years. Model simulations indicated that the surface waters of all twenty catchments acidified to the 1970s but showed subsequent recovery (increases in acid neutralising capacity (ANC and pH as sulphate deposition decreased. However, under proposed future emissions reductions (approximately 50% of current deposition simulated ANC and pH will not return to estimated pre-industrial levels by 2100. An ANC of 20 μmolc L−1 and pH of 5.4 were defined as acceptable chemical thresholds (or critical chemical limits for aquatic organisms in the current study. Under the proposed emissions reductions only one catchment is predicted to remain below the critical limit for ANC by 2100; three additional catchments are predicted to remain below the critical limit for pH. Dynamic models may be used to estimate target loads, i.e., the required deposition reductions to achieve recovery within a given time. Setting target loads at approximately 30% of current depositions would allow three of the four lakes to reach the chemical criteria by 2030. In contrast to the generally good prognosis for surface waters, soils lost an average of 32% of estimated initial base saturation and recovery is estimated to be very slow, averaging 23% lower than pre-acidification levels in 2100.

  19. Study on the Mathematical Model of Dielectric Recovery Characteristics in High Voltage SF6 Circuit Breaker

    Science.gov (United States)

    Lin, Xin; Wang, Feiming; Xu, Jianyuan; Xia, Yalong; Liu, Weidong

    2016-03-01

    According to the stream theory, this paper proposes a mathematical model of the dielectric recovery characteristic based on the two-temperature ionization equilibrium equation. Taking the dynamic variation of charged particle's ionization and attachment into account, this model can be used in collaboration with the Coulomb collision model, which gives the relationship of the heavy particle temperature and electron temperature to calculate the electron density and temperature under different pressure and electric field conditions, so as to deliver the breakdown electric field strength under different pressure conditions. Meanwhile an experiment loop of the circuit breaker has been built to measure the breakdown voltage. It is shown that calculated results are in conformity with experiment results on the whole while results based on the stream criterion are larger than experiment results. This indicates that the mathematical model proposed here is more accurate for calculating the dielectric recovery characteristic, it is derived from the stream model with some improvement and refinement and has great significance for increasing the simulation accuracy of circuit breaker's interruption characteristic. supported by Science and Technology Project of State Grid Corporation of China (No. GY17201200063), National Natural Science Foundation of China (No. 51277123), Basic Research Project of Liaoning Key Laboratory of Education Department (LZ2015055)

  20. Uncertainty Modeling for Robustness Analysis of Control Upset Prevention and Recovery Systems

    Science.gov (United States)

    Belcastro, Christine M.; Khong, Thuan H.; Shin, Jong-Yeob; Kwatny, Harry; Chang, Bor-Chin; Balas, Gary J.

    2005-01-01

    Formal robustness analysis of aircraft control upset prevention and recovery systems could play an important role in their validation and ultimate certification. Such systems (developed for failure detection, identification, and reconfiguration, as well as upset recovery) need to be evaluated over broad regions of the flight envelope and under extreme flight conditions, and should include various sources of uncertainty. However, formulation of linear fractional transformation (LFT) models for representing system uncertainty can be very difficult for complex parameter-dependent systems. This paper describes a preliminary LFT modeling software tool which uses a matrix-based computational approach that can be directly applied to parametric uncertainty problems involving multivariate matrix polynomial dependencies. Several examples are presented (including an F-16 at an extreme flight condition, a missile model, and a generic example with numerous crossproduct terms), and comparisons are given with other LFT modeling tools that are currently available. The LFT modeling method and preliminary software tool presented in this paper are shown to compare favorably with these methods.

  1. Improved Dynamic Modeling of the Cascade Distillation Subsystem and Integration with Models of Other Water Recovery Subsystems

    Science.gov (United States)

    Perry, Bruce; Anderson, Molly

    2015-01-01

    The Cascade Distillation Subsystem (CDS) is a rotary multistage distiller being developed to serve as the primary processor for wastewater recovery during long-duration space missions. The CDS could be integrated with a system similar to the International Space Station (ISS) Water Processor Assembly (WPA) to form a complete Water Recovery System (WRS) for future missions. Independent chemical process simulations with varying levels of detail have previously been developed using Aspen Custom Modeler (ACM) to aid in the analysis of the CDS and several WPA components. The existing CDS simulation could not model behavior during thermal startup and lacked detailed analysis of several key internal processes, including heat transfer between stages. The first part of this paper describes modifications to the ACM model of the CDS that improve its capabilities and the accuracy of its predictions. Notably, the modified version of the model can accurately predict behavior during thermal startup for both NaCl solution and pretreated urine feeds. The model is used to predict how changing operating parameters and design features of the CDS affects its performance, and conclusions from these predictions are discussed. The second part of this paper describes the integration of the modified CDS model and the existing WPA component models into a single WRS model. The integrated model is used to demonstrate the effects that changes to one component can have on the dynamic behavior of the system as a whole.

  2. A model-based approach to long-term recovery of limb apraxia after stroke.

    Science.gov (United States)

    Stamenova, Vessela; Black, Sandra E; Roy, Eric A

    2011-11-01

    Limb apraxia is a disorder affecting performance of gestures on verbal command (pantomime), on imitation, and/or in tool and action recognition. We aimed to examine recovery on tasks assessing both conceptual and production aspects of limb praxis in left (n = 22) and right (n = 15) stroke patients. Patients were assessed longitudinally on four conceptual tasks (action identification, tool naming by action, tool identification, and tool naming) and five production tasks (pantomime, pantomime by picture, concurrent imitation, delayed imitation, and tool use). They were grouped as impaired or not relative to the performance of a control sample (n = 27) and as acute-subacute (first assessment within 3 months post stroke) or chronic (over 3 months post stroke). Hierarchical linear modeling was used to analyze the data. Acute-subacute and chronic patients had similar average performance. All tasks, except action identification, showed evidence of recovery in both acute and chronic impaired patients. A faster rate of recovery among acute-subacute patients was observed only in the two pantomime tasks (action identification and tool identification were not compared on this factor).

  3. Isothermal recovery response and constitutive model of thermoset shape memory polymers

    Science.gov (United States)

    Tan, Huifeng; Zhou, Tao; Liu, Yuyan; Lan, Lan

    2012-04-01

    Deformation recovery capability is one of the important indexes to examination shape memory effect of the shape memory polymers (SMPs). And the shape memory characteristic of SMPs is closely related to different phase states and mechanical properties above and below the glass transition temperature (Tg). In this paper, we investigated the strain recovery response of a thermoset shape memory epoxy resin modified by polyurethane (PU) through uniaxial compression experiments under various isothermal conditions and strain rates and developed a "three-phase" constitutive model based on phase transition concept, which including stationary phase, active phase and frozen phase. This model established the mutual transformation relationships between frozen phase and active phase of SMPs by introducing temperature switch function, which presents the stain storage and release process of SMPs under loading and changing temperature environment. Besides, the proposed model represents the SMPs deformation process of viscous hysteresis response by employing the rheological elements description of the three phases. The numerical results agree very well with experiment results of stress-strain response curve of isothermal compression/unloading test, which validated this model can predict the finite deformation behavior of SMPs.

  4. Mesenchymal stem cell therapy promotes the improvement and recovery of renal function in a preclinical model

    Directory of Open Access Journals (Sweden)

    Antônio Urt Filho

    2016-01-01

    Full Text Available Abstract Acute renal failure (ARF is an extremely important public health issue in need of novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem cell (MSC therapy to promote the improvement and recovery of renal function in a preclinical model. Wistar rats were used as the experimental model, and our results show that cisplatin (5mg/kg can efficiently induce ARF, as measured by changes in biochemical (urea and creatinine and histological parameters. MSC therapy performed 24h after the administration of chemotherapy resulted in normalized plasma urea and creatinine levels 30 and 45d after the onset of kidney disease. Furthermore, MSC therapy significantly reduced histological changes (intratubular cast formation in protein overload nephropathy and tubular hydropic degeneration in this ARF model. Thus, considering that current therapies for ARF are merely palliative and that MSC therapy can promote the improvement and recovery of renal function in this model system, we suggest that innovative/alternative therapies involving MSCs should be considered for clinical studies in humans to treat ARF.

  5. Process Model of the Gas Recovery System in an IFE reactor

    Science.gov (United States)

    Gentile, Charles; Aristova, Maria

    2007-11-01

    It is necessary to develop a detailed representative model for the fuel recovery system (FRS) in the prospective direct drive inertial fusion energy (IFE) reactor. In order to observe the interaction of all components, a chemical process model is developed as part of the conceptual design phase of the project. Initially, the reactants, system structure, and processes are defined using the known contents of the vacuum vessel exhaust. The output, which will include physical properties and chemical content of the products, is analyzed to determine the most efficient and productive system parameters. The results of the modeling will be presented in this paper. This modeling exercise will be instrumental in optimizing and closing the fusion fuel cycle in the IFE power reactor.

  6. Modeling and Simulation of Membrane-Based Dehumidification and Energy Recovery Process

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Zhiming [ORNL; Abdelaziz, Omar [ORNL; Qu, Ming [ORNL

    2017-01-01

    This paper introduces a first-order physics-based model that accounts for the fundamental heat and mass transfer between a humid-air vapor stream on feed side to another flow stream on permeate side. The model comprises a few optional submodels for membrane mass transport; and it adopts a segment-by-segment method for discretizing heat and mass transfer governing equations for flow streams on feed and permeate sides. The model is able to simulate both dehumidifiers and energy recovery ventilators in parallel-flow, cross-flow, and counter-flow configurations. The predicted tresults are compared reasonably well with the measurements. The open-source codes are written in C++. The model and open-source codes are expected to become a fundament tool for the analysis of membrane-based dehumidification in the future.

  7. CONSTRUCTIVE MODELLING FOR ZONE OF RECOVERY ENERGY DISTRIBUTION OF DC TRACTION

    Directory of Open Access Journals (Sweden)

    V. I. Shynkarenko

    2016-10-01

    Full Text Available Purpose.The article is aimed to develop the means and methods of forming a plurality of real and potential structural diagrams for zones of energy recovery and different locations of trains for further training neuro-fuzzy networks on the basis of expert solutions and also for the formation of good control. Methodology. Methodology of mathematical and algorithmic constructivism for modeling the structural diagrams of the electric supply system and modes of traction power consumption and the train’s locations in zones of energy recovery was applied. This approach involves the development of constructive-synthesizing structures (CSS with transformation by specialization, interpretation, specification and implementation. Development CSS provides an extensible definition media, relations and the signature of operations and constructive axiomatic. The most complex and essential part of the axioms is the set formed by the substitution rules defining the process of withdrawal of the corresponding structures. Findings. A specialized and specified CSS, which allows considering all the possibilities and features, that supply power traction systems with modern equipment, stations and trains location was designed. Its feature: the semantic content of the terminal alphabet images of electrical traction network and power consumers with relevant attributes. A special case of the formation of the structural diagram shows the possibilities CSS in relation to this problem. Originality. A new approach to solving the problem of rational use of energy recovery, which consists in application of the methods and means of artificial neural networks, expert systems, fuzzy logic and mathematical and algorithmic constructivism. This paper presents the methods of constructive simulation of a production-distribution of energy recovery zone structure in the system of the DC traction. Practical value. The tasks decision of the rational use of energy recovery can

  8. The recovery paradigm - a model of hope and change for alcohol and drug addiction.

    Science.gov (United States)

    Best, David W; Lubman, Dan I

    2012-08-01

    Alcohol and drug disorders remain major health and social problems in Australia, contributing enormously to the global burden of disease and the everyday practice of primary care. A recent growth in recovery research and recovery focused policies are starting to have an impact in Australia, with implications for how we attempt to resolve these problems. In this article we discuss recent international findings in recovery research, and explore their implications for primary care. Research indicates that over half of dependent substance users will eventually achieve stable recovery. Key predictors of recovery are active engagement in the community and immersion in peer support groups and activities. Recovery requires a twin track approach: enabling and supporting individual recovery journeys, while creating environmental conditions that enable and support a 'social contagion' of recovery, in which recovery is transmitted through supportive social networks and dedicated recovery groups, such as mutual aid.

  9. A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model.

    Science.gov (United States)

    Malik, Amir S; Narayan, Raj K; Wendling, Woodrow W; Cole, Russell W; Pashko, Laura L; Schwartz, Arthur G; Strauss, Kenneth I

    2003-05-01

    The purpose of this study was to investigate the efficacy of a novel steroid, fluasterone (DHEF, a dehydroepiandrosterone (DHEA) analog), at improving functional recovery in a rat model of traumatic brain injury (TBI). The lateral cortical impact model was utilized in two studies of efficacy and therapeutic window. DHEF was given (25 mg/kg, intraperitoneally) at the initial time point and once a day for 2 more days. Study A included four groups: sham injury, vehicle treated (n = 22); injured, vehicle treated (n = 30); injured, pretreated (5-10 min prior to injury, n = 24); and injured, posttreated (initial dose 30 min postinjury, n = 15). Study B (therapeutic window) included five groups: sham injury, vehicle treated (n = 17); injured, vehicle treated (n = 26); and three posttreatment groups: initial dose at 30 min (n = 18), 2 h (n = 23), or 12 h (n = 16) postinjury. Three criteria were used to grade functional recovery. In study A, DHEF improved beam walk performance both with pretreatment (79%) and 30-min posttreatment group (54%; p memory (Morris water maze) and neurological reflexes both revealed significant improvements in all DHEF treatment groups. In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. In contrast, DHEF treatment did not alter injury-induced COX2 mRNA levels in the cortex or hippocampus. However, DHEF (and DHEA) relaxed ex vivo bovine middle cerebral artery preparations by about 30%, with an IC(50) approximately 40 microM. This was a direct effect on the vascular smooth muscle, independent of the endothelial cell layer. Fluasterone (DHEF) treatments improved functional recovery in a rat TBI model. Possible mechanisms of action for this novel DHEA analog are discussed. These findings suggest an exciting potential use for this agent in the clinical treatment of traumatic brain injury.

  10. Mass Balance Model for Sustainable Phosphorus Recovery in a US Wastewater Treatment Plant.

    Science.gov (United States)

    Venkatesan, Arjun K; Hamdan, Abdul-Hakeem M; Chavez, Vanessa M; Brown, Jasmine D; Halden, Rolf U

    2016-01-01

    In response to limited phosphorus (P) reserves worldwide, several countries have demonstrated the prospect of recovering significant amounts of P from wastewater treatment plants (WWTPs). This technique uses enhanced biological P removal (EBPR) to concentrate P in sludge followed by chemical precipitation of P as struvite, a usable phosphate mineral. The present study models the feasibility of this enhanced removal and recovery technique in a WWTP in Arizona with design parameters typical of infrastructure in the United States. A mass balance was performed for existing treatment processes and modifications proposed to estimate the quantity of P that could be recovered under current and future flow conditions. Modeling results show that about 71 to 96% of the P being lost potentially could be recovered as struvite. About 491 ± 64 t yr of struvite may be recovered after process modification, which corresponds to $150,000 ± $20,000 yr in P sales to fertilizer industries. The process was projected to be economically feasible, with a payback period of 45 ± 30 yr in the studied WWTP and a much shorter duration of 3 ± 1 yr for WWTPs already using an EBPR process. Furthermore, modeling results suggest that P recovery can improve the quality of biosolids by favorably reducing the P:N ratio. Implementation of this strategy at US WWTPs may increase national security by reducing dependence of limited P resources. Considering all aspects of the recovery process with respect to environmental, economic, and social implications, the examined technique is concluded to represent a cost-attractive and sustainable method for P management in US WWTPs.

  11. Development of an end-of-life vehicle recovery model using system dynamics and future research needs

    Science.gov (United States)

    Mohamad-Ali, N.; Ghazilla, R. A. R.; Abdul-Rashid, S. H.; Sakundarini, N.; Ahmad-Yazid, A.; Stephenie, L.

    2017-06-01

    The implementation of end-of-life vehicle (ELV) recovery policy in Malaysia has led vehicle manufacturers to look at different ways to improve design and development of vehicles. Nowadays, it is crucial to incorporate end-of-life (EOL) design strategies into the vehicle design in order to enhance the effectiveness of the ELV recovery network. Although recent studies have shown that product design has a significant effect on the product recovery rate, there is a lack of studies on how EOL design strategies affects the effectiveness of ELV recovery, particularly when there are dynamic changes in the behaviour of the product recovery network. Thus, in this study, we developed a preliminary model based on the system dynamics approach in order to predict the effectiveness of ELV recovery in response to dynamic changes of various factors (including EOL design strategies) in the business environment. We developed this model based on preliminary data that we had gathered from unstructured interviews with the key stakeholders of ELV management in Malaysia. We believe that our model will greatly benefit product designers in incorporating the appropriate EOL design strategies in order to boost ELV recovery effectiveness in Malaysia.

  12. Reactive transport modeling at uranium in situ recovery sites: uncertainties in uranium sorption on iron hydroxides

    Science.gov (United States)

    Johnson, Raymond H.; Tutu, Hlanganani; Brown, Adrian; Figueroa, Linda; Wolkersdorfer, Christian

    2013-01-01

    Geochemical changes that can occur down gradient from uranium in situ recovery (ISR) sites are important for various stakeholders to understand when evaluating potential effects on surrounding groundwater quality. If down gradient solid-phase material consists of sandstone with iron hydroxide coatings (no pyrite or organic carbon), sorption of uranium on iron hydroxides can control uranium mobility. Using one-dimensional reactive transport models with PHREEQC, two different geochemical databases, and various geochemical parameters, the uncertainties in uranium sorption on iron hydroxides are evaluated, because these oxidized zones create a greater risk for future uranium transport than fully reduced zones where uranium generally precipitates.

  13. A leech model for homeostatic plasticity and motor network recovery after loss of descending inputs.

    Science.gov (United States)

    Lane, Brian J

    2016-04-01

    Motor networks below the site of spinal cord injury (SCI) and their reconfiguration after loss of central inputs are poorly understood but remain of great interest in SCI research. Harley et al. (J Neurophysiol 113: 3610-3622, 2015) report a striking locomotor recovery paradigm in the leech Hirudo verbena with features that are functionally analogous to SCI. They propose that this well-established neurophysiological system could potentially be repurposed to provide a complementary model to investigate basic principles of homeostatic compensation relevant to SCI research.

  14. Statistical Modeling Studies of Iron Recovery from Red Mud Using Thermal Plasma

    Science.gov (United States)

    Swagat, S. Rath; Archana, Pany; Jayasankar, K.; Ajit, K. Mitra; C. Satish, Kumar; Partha, S. Mukherjee; Barada, K. Mishra

    2013-05-01

    Optimization studies of plasma smelting of red mud were carried out. Reduction of the dried red mud fines was done in an extended arc plasma reactor to recover the pig iron. Lime grit and low ash metallurgical (LAM) coke were used as the flux and reductant, respectively. 2-level factorial design was used to study the influence of all parameters on the responses. Response surface modeling was done with the data obtained from statistically designed experiments. Metal recovery at optimum parameters was found to be 79.52%.

  15. Numerical modelling and prediction of abandoned mine methane recovery: field application at the Saar coalfield, Germany

    Energy Technology Data Exchange (ETDEWEB)

    Sevket Durucan; Ji Quan Shi; Anna Korre [Imperial College of Science Technology and Medicine, London (United Kingdom). T H Huxley School of Environment, Earth Sciences and Engineering

    2004-07-01

    In a recently completed EC- Thermie research project, jointly carried out by Imperial College and Deutsche Steinkohle Aktiengesellschaft (DSK), an in house gas-water two-phase CBM simulator developed at Imperial College London was modified to simulate abandoned mine methane recovery in the Saar Coalfield. Historical data on mining and methane emissions, as well as the long-term methane production data monitored from the Hangard shaft was used to validate the model developed. A satisfactory match to the historical and current field data was achieved, and predictions for future production opportunities were made. 4 refs., 10 figs.

  16. Modelling of Evaporator in Waste Heat Recovery System using Finite Volume Method and Fuzzy Technique

    Directory of Open Access Journals (Sweden)

    Jahedul Islam Chowdhury

    2015-12-01

    Full Text Available The evaporator is an important component in the Organic Rankine Cycle (ORC-based Waste Heat Recovery (WHR system since the effective heat transfer of this device reflects on the efficiency of the system. When the WHR system operates under supercritical conditions, the heat transfer mechanism in the evaporator is unpredictable due to the change of thermo-physical properties of the fluid with temperature. Although the conventional finite volume model can successfully capture those changes in the evaporator of the WHR process, the computation time for this method is high. To reduce the computation time, this paper develops a new fuzzy based evaporator model and compares its performance with the finite volume method. The results show that the fuzzy technique can be applied to predict the output of the supercritical evaporator in the waste heat recovery system and can significantly reduce the required computation time. The proposed model, therefore, has the potential to be used in real time control applications.

  17. Modeling assessment for ammonium nitrogen recovery from wastewater by chemical precipitation

    Institute of Scientific and Technical Information of China (English)

    Tao Zhang; Qiucheng Li; Lili Ding; Hongqiang Ren; Ke Xu; Yonggang Wu; Dong Sheng

    2011-01-01

    Chemical precipitation to form magnesium ammonium phosphate (MAP) is an effective technology for recovering ammonium nitrogen (NH4+-N). In the present research, we investigated the thermodynamic modeling of the PHREEQC program for NH4+-N recovery to evaluate the effect of reaction factors on MAP precipitation. The case study of NH4+-N recovery from coking wastewater was conducted to provide a comparison. Response surface methodology (RSM) was applied to assist in understanding the relative significance of reaction factors and the interactive effects of solution conditons. Thermodynamic modeling indicated that the saturation index (SI) of MAP followed a polynomial function of pH. The SI of MAP increased logarithmically with the Mg2+/NH4+ molar ratio (Mg/N) and the initial NH4+-N concentration (CN), respectively, while it decreased with an increase in Ca2+/NH4+ and CO32-/NH4+molar ratios (Ca/N and CO32-/N), respectively. The trends for NH4+-N removal at different pH and Mg/N levels were similar to the thermodynamic modeling predictions. The RSM analysis indicated that the factors including pH, Mg/N, CN, Ca/N, (Mg/N)× (CO32-/N),(pH)2, (Mg/N)2, and (CN)2 were significant. Response surface plots were useful for understanding the interaction effects on NH4+-Nrecovery.

  18. Assessing potential health impacts of waste recovery and reuse business models in Hanoi, Vietnam.

    Science.gov (United States)

    Winkler, Mirko S; Fuhrimann, Samuel; Pham-Duc, Phuc; Cissé, Guéladio; Utzinger, Jürg; Nguyen-Viet, Hung

    2017-02-01

    In resource-constrained settings, the recovery of nutrients and the production of energy from liquid and solid waste are important. We determined the range and magnitude of potential community health impacts of six solid and liquid waste recovery and reuse business models in Hanoi, Vietnam. We employed a health impact assessment (HIA) approach using secondary data obtained from various sources supplemented with primary data collection. For determining the direction (positive or negative) and magnitude of potential health impacts in the population, a semiquantitative impact assessment was pursued. From a public health perspective, wastewater reuse for inland fish farming, coupled with on-site water treatment has considerable potential for individual and community-level health benefits. One of the business models investigated (i.e. dry fuel manufacturing with agro-waste) resulted in net negative health impacts. In Hanoi, the reuse of liquid and solid waste-as a mean to recover water and nutrients and to produce energy-has considerable potential for health benefits if appropriately managed and tailored to local contexts. Our HIA methodology provides an evidence-based decision-support tool for identification and promotion of business models for implementation in Hanoi.

  19. Dynamic Modeling of Process Technologies for Closed-Loop Water Recovery Systems

    Science.gov (United States)

    Allada, Rama Kumar; Lange, Kevin E.; Anderson, Molly S.

    2012-01-01

    Detailed chemical process simulations are a useful tool in designing and optimizing complex systems and architectures for human life support. Dynamic and steady-state models of these systems help contrast the interactions of various operating parameters and hardware designs, which become extremely useful in trade-study analyses. NASA s Exploration Life Support technology development project recently made use of such models to compliment a series of tests on different waste water distillation systems. This paper presents dynamic simulations of chemical process for primary processor technologies including: the Cascade Distillation System (CDS), the Vapor Compression Distillation (VCD) system, the Wiped-Film Rotating Disk (WFRD), and post-distillation water polishing processes such as the Volatiles Removal Assembly (VRA). These dynamic models were developed using the Aspen Custom Modeler (Registered TradeMark) and Aspen Plus(Registered TradeMark) process simulation tools. The results expand upon previous work for water recovery technology models and emphasize dynamic process modeling and results. The paper discusses system design, modeling details, and model results for each technology and presents some comparisons between the model results and available test data. Following these initial comparisons, some general conclusions and forward work are discussed.

  20. Numerical Modeling of Fin and Tube Heat Exchanger for Waste Heat Recovery

    DEFF Research Database (Denmark)

    Singh, Shobhana; Sørensen, Kim; Condra, Thomas Joseph

    associates conjugate heat transfer phenomenon with the turbulent flow to describe the variable temperature and velocity profile. The performance of heat exchanger design is investigated in terms of overall heat transfer coefficient, Nusselt number, Colburn j-factor, flow resistance factor, and efficiency......In the present work, multiphysics numerical modeling is carried out to predict the performance of a liquid-gas fin and tube heat exchanger design. Three-dimensional (3D) steady-state numerical model using commercial software COMSOL based on finite element method (FEM) is developed. The study...... between fin and tube. The present numerical model predicts the performance of the heat exchanger design, therefore, can be applied to existing waste heat recovery systems to improve the overall performance with optimized design and process-dependent parameters....

  1. Model based investigation of the potential lactate recovery using Electro-Enhanced Dialysis - Static analysis

    DEFF Research Database (Denmark)

    Prado Rubio, Oscar Andres; Jørgensen, Sten Bay; Jonsson, Gunnar Eigil

    2011-01-01

    The competitive ion transport through anion exchange membranes under current load conditions, referred to as the electro-enhanced dialysis process, is modeled and investigated through simulations. A dynamic model has been developed for simultaneous transport of multiple ions based on the Nernst......–Plank equation. This model accounts for the convective transport of the dissociated and undissociated species in the module channels, and the diffusion and migration across the boundary layers and membranes. The potential static flux enhancement is evaluated and compared to Donnan dialysis operation for lactate...... recovery, where lactate fluxes were increased up to 230%. The effect of the imposed current on the concentration profiles is analyzed. Furthermore, the current saturation condition is investigated for the proposed electro-enhanced dialysis system. Thus, the operating window for current density and inlet...

  2. Specification and Design of a Fault Recovery Model for the Reliable Multicast Protocol

    Science.gov (United States)

    Montgomery, Todd; Callahan, John R.; Whetten, Brian

    1996-01-01

    The Reliable Multicast Protocol (RMP) provides a unique, group-based model for distributed programs that need to handle reconfiguration events at the application layer. This model, called membership views, provides an abstraction in which events such as site failures, network partitions, and normal join-leave events are viewed as group reformations. RMP provides access to this model through an application programming interface (API) that notifies an application when a group is reformed as the result of a some event. RMP provides applications with reliable delivery of messages using an underlying IP Multicast media to other group members in a distributed environment even in the case of reformations. A distributed application can use various Quality of Service (QoS) levels provided by RMP to tolerate group reformations. This paper explores the implementation details of the mechanisms in RMP that provide distributed applications with membership view information and fault recovery capabilities.

  3. microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model.

    Directory of Open Access Journals (Sweden)

    Fu Jia Liu

    Full Text Available To date, miRNA expression studies on cerebral ischemia in both human and animal models have focused mainly on acute phase of ischemic stroke. In this study, we present the roles played by microRNAs in the spontaneous recovery phases in cerebral ischemia using rodent stroke models. Brain tissues were harvested at different reperfusion time points ranging from 0-168 hrs after middle cerebral artery occlusion using homologous emboli. MiRNA and mRNA expression profiles were investigated by microarray followed by multiple statistical analysis. Candidate transcripts were also validated by quantitative RT-PCR. Three specific groups of miRNAs were observed among a total of 346 differentially expressed miRNAs. miRNAs, miR-21, -142-3p, -142-5p, and -146a displayed significant upregulation during stroke recovery (48 hrs to 168 hrs compared with those during acute phases (0 hrs to 24 hrs. On the other hand, an opposite trend was observed in the expression of miR-196a/b/c, -224 and -324-3p. Interestingly, miR-206, -290, -291a-5p and -30c-1*, positively correlated with the infarct sizes, with an initial increase up to 24hrs followed by a gradual decrease from 48 hrs to 168 hrs (R = 0.95. Taken together with the expression levels of corresponding mRNA targets, we have also found that Hedgehog, Notch, Wnt and TGF-β signaling pathways could play significant roles in stroke recovery and especially in neuronal repair.

  4. The recovery boiler advisor. Combination of practical experience and advanced thermodynamic modelling

    Energy Technology Data Exchange (ETDEWEB)

    Backman, R. [Aabo Akademi, Turku (Finland); Eriksson, G. [LTH/RWTH (Germany); Sundstroem, K. [Tampella Power Oy, Tampere (Finland)

    1996-12-31

    The Aabo Advisor is a computer based program intended to provide information about the high temperature ash and fluegas chemistry in pulping spent black liquor recovery boilers of kraft pulp mills. The program can be used for predictions of a variety of furnace and flue gas phenomena, such as fireside fouling of the heat exchanger surfaces caused by the flue gas particulate matter, emissions of SO{sub 2}(g), HCl(g) and NO{sub x}(g) with the flue gas etc. The program determines the composition of the fluegas as well as the amount and composition of the two typical fly ash fractions found in recovery boiler fluegases, the condensed fly ash particles and the carry over particles. These data are used for calculating the melting behavior of the fly ash present at different locations in the boiler and this characteristic behavior is used for the fireside fouling predictions. The program may also be used for studying how different mill processes affecting the black liquor composition affects on the fireside chemistry of the recovery boiler. As input data for the calculations only a few boiler operation parameters and the composition of the black liquor is required. The calculations are based on a one-dimensional, multi-stage chemistry model where both thermodynamic equilibrium calculations and stoichiometric material balances are used. The model calculates at first the chemistry in the lower furnace and smelt after which it moves to the upper furnace and the radiative parts of the fluegas channel. As the last block the program calculates the chemistry in the convective part, the electrostatic precipitator cath and stack. The results from each block are presented in tables, key numbers and melt curves representing the fluegas or fly ash fraction present at each location

  5. The Virtual Brain: Modeling Biological Correlates of Recovery after Chronic Stroke.

    Science.gov (United States)

    Falcon, Maria Inez; Riley, Jeffrey D; Jirsa, Viktor; McIntosh, Anthony R; Shereen, Ahmed D; Chen, E Elinor; Solodkin, Ana

    2015-01-01

    There currently remains considerable variability in stroke survivor recovery. To address this, developing individualized treatment has become an important goal in stroke treatment. As a first step, it is necessary to determine brain dynamics associated with stroke and recovery. While recent methods have made strides in this direction, we still lack physiological biomarkers. The Virtual Brain (TVB) is a novel application for modeling brain dynamics that simulates an individual's brain activity by integrating their own neuroimaging data with local biophysical models. Here, we give a detailed description of the TVB modeling process and explore model parameters associated with stroke. In order to establish a parallel between this new type of modeling and those currently in use, in this work we establish an association between a specific TVB parameter (long-range coupling) that increases after stroke with metrics derived from graph analysis. We used TVB to simulate the individual BOLD signals for 20 patients with stroke and 10 healthy controls. We performed graph analysis on their structural connectivity matrices calculating degree centrality, betweenness centrality, and global efficiency. Linear regression analysis demonstrated that long-range coupling is negatively correlated with global efficiency (P = 0.038), but is not correlated with degree centrality or betweenness centrality. Our results suggest that the larger influence of local dynamics seen through the long-range coupling parameter is closely associated with a decreased efficiency of the system. We thus propose that the increase in the long-range parameter in TVB (indicating a bias toward local over global dynamics) is deleterious because it reduces communication as suggested by the decrease in efficiency. The new model platform TVB hence provides a novel perspective to understanding biophysical parameters responsible for global brain dynamics after stroke, allowing the design of focused therapeutic

  6. Dynamic Modeling of Process Technologies for Closed-Loop Water Recovery Systems

    Science.gov (United States)

    Allada, Rama Kumar; Lange, Kevin; Anderson, Molly

    2011-01-01

    Detailed chemical process simulations are a useful tool in designing and optimizing complex systems and architectures for human life support. Dynamic and steady-state models of these systems help contrast the interactions of various operating parameters and hardware designs, which become extremely useful in trade-study analyses. NASA s Exploration Life Support technology development project recently made use of such models to compliment a series of tests on different waste water distillation systems. This paper presents dynamic simulations of chemical process for primary processor technologies including: the Cascade Distillation System (CDS), the Vapor Compression Distillation (VCD) system, the Wiped-Film Rotating Disk (WFRD), and post-distillation water polishing processes such as the Volatiles Removal Assembly (VRA) that were developed using the Aspen Custom Modeler and Aspen Plus process simulation tools. The results expand upon previous work for water recovery technology models and emphasize dynamic process modeling and results. The paper discusses system design, modeling details, and model results for each technology and presents some comparisons between the model results and available test data. Following these initial comparisons, some general conclusions and forward work are discussed.

  7. Analysis of Infectious-Recovery Epidemic Models for Membership Dynamics of Online Social Networks

    CERN Document Server

    Cooney, Daniel; Bar-Yam, Yaneer

    2016-01-01

    The recent rapid growth of social media and online social networks (OSNs) has raised interesting questions about the spread of ideas and fads within our society. In the past year, several papers have drawn analogies between the rise and fall in popularity of OSNs and mathematical models used to study infectious disease. One such model, the irSIR model, made use of the idea of "infectious recovery" to outperform the traditional SIR model in replicating the rise and fall of MySpace and to predict a rapid drop in the popularity of Facebook. Here we explore the irSIR model and two of its logical extensions and we mathematically characterize the initial and long-run behavior of these dynamical systems. In particular, while the original irSIR model always predicts extinction of a social epidemic, we construct an extension of the model that matches the exponential growth phase of the irSIR model while allowing for the possibility of an arbitrary proportion of infections in the long run.

  8. Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Lu Chen

    2014-06-01

    Full Text Available Using a viral model of the demyelinating disease multiple sclerosis (MS, we show that intraspinal transplantation of human embryonic stem cell-derived neural precursor cells (hNPCs results in sustained clinical recovery, although hNPCs were not detectable beyond day 8 posttransplantation. Improved motor skills were associated with a reduction in neuroinflammation, decreased demyelination, and enhanced remyelination. Evidence indicates that the reduced neuroinflammation is correlated with an increased number of CD4+CD25+FOXP3+ regulatory T cells (Tregs within the spinal cords. Coculture of hNPCs with activated T cells resulted in reduced T cell proliferation and increased Treg numbers. The hNPCs acted, in part, through secretion of TGF-β1 and TGF-β2. These findings indicate that the transient presence of hNPCs transplanted in an animal model of MS has powerful immunomodulatory effects and mediates recovery. Further investigation of the restorative effects of hNPC transplantation may aid in the development of clinically relevant MS treatments.

  9. Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model.

    Science.gov (United States)

    Parish, Clare L; Beljajeva, Anna; Arenas, Ernest; Simon, András

    2007-08-01

    Death and lack of functional regeneration of midbrain dopaminergic (DA) neurons, decreased DA input in the target striatum and movement anomalies characterise Parkinson's disease (PD). There is currently no cure for PD. One way to promote recovery would be to induce or enhance DA neurogenesis. Whether DA neurogenesis occurs in the adult midbrain is a matter of debate. Here, we describe the creation of a salamander 6-hydroxydopamine model of PD to examine midbrain DA regeneration. We demonstrate a robust and complete regeneration of the mesencephalic and diencephalic DA system after elimination of DA neurons. Regeneration is contributed by DA neurogenesis, leads to histological restoration, and to full recovery of motor behaviour. Molecular analyses of the temporal expression pattern of DA determinants indicate that the regenerating DA neurons mature along a similar developmental program as their mammalian counterparts during embryogenesis. We also find that the adult salamander midbrain can reactivate radial glia-like ependymoglia cells that proliferate. The salamander model provides insights into the mechanisms of DA regeneration/neurogenesis and may contribute to the development of novel regenerative strategies for the mammalian brain.

  10. Observation Likelihood Model Design and Failure Recovery Scheme toward Reliable Localization of Mobile Robots

    Directory of Open Access Journals (Sweden)

    Chang-bae Moon

    2011-01-01

    Full Text Available Although there have been many researches on mobile robot localization, it is still difficult to obtain reliable localization performance in a human co-existing real environment. Reliability of localization is highly dependent upon developer's experiences because uncertainty is caused by a variety of reasons. We have developed a range sensor based integrated localization scheme for various indoor service robots. Through the experience, we found out that there are several significant experimental issues. In this paper, we provide useful solutions for following questions which are frequently faced with in practical applications: 1 How to design an observation likelihood model? 2 How to detect the localization failure? 3 How to recover from the localization failure? We present design guidelines of observation likelihood model. Localization failure detection and recovery schemes are presented by focusing on abrupt wheel slippage. Experiments were carried out in a typical office building environment. The proposed scheme to identify the localizer status is useful in practical environments. Moreover, the semi-global localization is a computationally efficient recovery scheme from localization failure. The results of experiments and analysis clearly present the usefulness of proposed solutions.

  11. Recovery among Adolescents: Models for Post-Treatment Gains in Drug Abuse Treatments

    Science.gov (United States)

    Joe, George W.; Knight, Danica Kalling; Becan, Jennifer E.; Flynn, Patrick M.

    2013-01-01

    Recovery among adolescents undergoing substance abuse treatment was modeled in terms of pre-treatment motivation, therapeutic relationships, psychological functioning, treatment retention, legal pressures, DSM diagnoses, and client demographics. To address between program differences, a within-covariance matrix, based on 547 youth, was used. Applicability of the results across treatment modalities was also examined. The data were from the NIDA-sponsored DATOS Adolescent study. Results from structural equation models (estimated using Mplus) indicated that higher pre-treatment motivation predicted stronger counselor and in-treatment peer relationships, better counselor relationships and retention predicted less illegal drug use at follow-up, and DSM diagnosis was important in the treatment process. Overall, illegal drug use at follow-up was associated with post-treatment alcohol consumption, cigarette use, condom nonuse, psychological distress, criminality, and school non-attendance. The results document the importance of motivation and therapeutic relationships on recovery, even when taking into account the relative effects of legal pressures, DSM diagnoses, and demographics. PMID:24238715

  12. Two-phase plate-fin heat exchanger modeling for waste heat recovery systems in diesel engines

    NARCIS (Netherlands)

    Feru, E.; de Jager, B.; Willems, F.; Steinbuch, M.

    2014-01-01

    This paper presents the modeling and model validation for a modular two-phase heat exchanger that recovers energy in heavy-duty diesel engines. The model is developed for temperature and vapor quality prediction and for control design of the waste heat recovery system. In the studied waste heat reco

  13. Experimental campaign and modeling of a low capacity waste heat recovery system based on a single screw expander

    OpenAIRE

    2014-01-01

    In recent years, due to the increasing concern over energy shortage and global warming, the interest in low grade heat recovery from industrial processes has grown dramatically. Several studies have underlined the potential of small-capacity Organic Rankine Cycle (ORC) power plants for Waste Heat Recovery (WHR) applications. For such systems, accurate models based on actual experimental data represent an important tool, in particular when control issues are considered. This paper presents an ...

  14. A new muscle fatigue and recovery model and its ergonomics application in human simulation

    CERN Document Server

    Ma, Liang; Bennis, Fouad; Zhang, Wei; Guillaume, François; 10.1080/17452759.2010.504056

    2010-01-01

    Although automatic techniques have been employed in manufacturing industries to increase productivity and efficiency, there are still lots of manual handling jobs, especially for assembly and maintenance jobs. In these jobs, musculoskeletal disorders (MSDs) are one of the major health problems due to overload and cumulative physical fatigue. With combination of conventional posture analysis techniques, digital human modelling and simulation (DHM) techniques have been developed and commercialized to evaluate the potential physical exposures. However, those ergonomics analysis tools are mainly based on posture analysis techniques, and until now there is still no fatigue index available in the commercial software to evaluate the physical fatigue easily and quickly. In this paper, a new muscle fatigue and recovery model is proposed and extended to evaluate joint fatigue level in manual handling jobs. A special application case is described and analyzed by digital human simulation technique.

  15. Positive life events, attributional style, and hopefulness: testing a model of recovery from depression.

    Science.gov (United States)

    Needles, D J; Abramson, L Y

    1990-05-01

    A model of a recovery process from depression that is compatible with the hopelessness theory of depressive onset is proposed. This model predicts that depressives who have an enhancing attributional style for positive events (i.e., make global, stable attributions for such events) will be more likely to regain hopefulness and, thereby, recover from depression, when positive events occur. This prediction was tested by following a group of depressed college students longitudinally for 6 weeks. Although neither positive events alone nor attributional style alone predicted reduction in hopelessness, depressives who both showed the enhancing attributional style for positive events and experienced more positive events showed dramatic reductions in hopelessness which were accompanied by remission of depressive symptoms. Thus, attributional style for positive events may be a factor that enables some depressives to recover when positive events occur in their lives.

  16. A Recovery Model for Production Scheduling: Combination of Disruption Management and Internet of Things

    Directory of Open Access Journals (Sweden)

    Yang Jiang

    2016-01-01

    Full Text Available It is difficult to generate the new schedule effectively for minimizing the negative impact when an unanticipated disruption occurs after a subset of tasks has been finished in production scheduling. In such cases, continuing with the original schedule may not be optimal or feasible. Based on disruption management and Internet of things (IoT, this study designs a real-time status analyzer to identify the disruption and propose a recovery model to deal with the disruption. The computational result proves that our algorithm is competitive with the existing heuristics. Furthermore, due to the tradeoff between all participators (mainly including customers, managers of production enterprise, and workers involved in production scheduling, our model is more effective than the total rescheduling and right-shift rescheduling.

  17. Model study of enhanced oil recovery by flooding with aqueous surfactant solution and comparison with theory.

    Science.gov (United States)

    Fletcher, Paul D I; Savory, Luke D; Woods, Freya; Clarke, Andrew; Howe, Andrew M

    2015-03-17

    With the aim of elucidating the details of enhanced oil recovery by surfactant solution flooding, we have determined the detailed behavior of model systems consisting of a packed column of calcium carbonate particles as the porous rock, n-decane as the trapped oil, and aqueous solutions of the anionic surfactant sodium bis(2-ethylhexyl) sulfosuccinate (AOT). The AOT concentration was varied from zero to above the critical aggregation concentration (cac). The salt content of the aqueous solutions was varied to give systems of widely different, post-cac oil-water interfacial tensions. The systems were characterized in detail by measuring the permeability behavior of the packed columns, the adsorption isotherms of AOT from the water to the oil-water interface and to the water-calcium carbonate interface, and oil-water-calcium carbonate contact angles. Measurements of the percent oil recovery by pumping surfactant solutions into calcium carbonate-packed columns initially filled with oil were analyzed in terms of the characterization results. We show that the measured contact angles as a function of AOT concentration are in reasonable agreement with those calculated from values of the surface energy of the calcium carbonate-air surface plus the measured adsorption isotherms. Surfactant adsorption onto the calcium carbonate-water interface causes depletion of its aqueous-phase concentration, and we derive equations which enable the concentration of nonadsorbed surfactant within the packed column to be estimated from measured parameters. The percent oil recovery as a function of the surfactant concentration is determined solely by the oil-water-calcium carbonate contact angle for nonadsorbed surfactant concentrations less than the cac. For surfactant concentrations greater than the cac, additional oil removal occurs by a combination of solubilization and emulsification plus oil mobilization due to the low oil-water interfacial tension and a pumping pressure increase.

  18. Modeling Neurocognitive Decline and Recovery During Repeated Cycles of Extended Sleep and Chronic Sleep Deficiency.

    Science.gov (United States)

    St Hilaire, Melissa A; Rüger, Melanie; Fratelli, Federico; Hull, Joseph T; Phillips, Andrew J K; Lockley, Steven W

    2017-01-01

    Intraindividual night-to-night sleep duration is often insufficient and variable. Here we report the effects of such chronic variable sleep deficiency on neurobehavioral performance and the ability of state-of-the-art models to predict these changes. Eight healthy males (mean age ± SD: 23.9 ± 2.4 years) studied at our inpatient intensive physiologic monitoring unit completed an 11-day protocol with a baseline 10-hour sleep opportunity and three cycles of two 3-hour time-in-bed (TIB) and one 10-hour TIB sleep opportunities. Participants received one of three polychromatic white light interventions (200 lux 4100K, 200 or 400 lux 17000K) for 3.5 hours on the morning following the second 3-hour TIB opportunity each cycle. Neurocognitive performance was assessed using the psychomotor vigilance test (PVT) administered every 1-2 hours. PVT data were compared to predictions of five group-average mathematical models that incorporate chronic sleep loss functions. While PVT performance deteriorated cumulatively following each cycle of two 3-hour sleep opportunities, and improved following each 10-hour sleep opportunity, performance declined cumulatively throughout the protocol at a more accelerated rate than predicted by state-of-the-art group-average mathematical models. Subjective sleepiness did not reflect performance. The light interventions had minimal effect. Despite apparent recovery following each extended sleep opportunity, residual performance impairment remained and deteriorated rapidly when rechallenged with subsequent sleep loss. None of the group-average models were capable of predicting both the build-up in impairment and recovery profile of performance observed at the group or individual level, raising concerns regarding their use in real-world settings to predict performance and improve safety.

  19. Modeling forest disturbance and recovery in secondary subtropical dry forests of Puerto Rico

    Science.gov (United States)

    Holm, J. A.; Shugart, H. H., Jr.; Van Bloem, S. J.

    2015-12-01

    Because of human pressures, the need to understand and predict the long-term dynamics of subtropical dry forests is urgent. Through modifications to the ZELIG vegetation demographic model, including the development of species- and site-specific parameters and internal modifications, the capability to predict forest change within the Guanica State Forest in Puerto Rico can now be accomplished. One objective was to test the capability of this new model (i.e. ZELIG-TROP) to predict successional patterns of secondary forests across a gradient of abandoned fields currently being reclaimed as forests. Model simulations found that abandoned fields that are on degraded lands have a delayed response to fully recover and reach a mature forest status during the simulated time period; 200 years. The forest recovery trends matched predictions published in other studies, such that attributes involving early resource acquisition (i.e. canopy height, canopy coverage, density) were the fastest to recover, but attributes used for structural development (i.e. biomass, basal area) were relatively slow in recovery. Biomass and basal area, two attributes that tend to increase during later successional stages, are significantly lower during the first 80-100 years of recovery compared to a mature forest, suggesting that the time scale of resilience in subtropical dry forests needs to be partially redefined. A second objective was to investigate the long and short-term effects of increasing hurricane disturbances on vegetation structure and dynamics, due to hurricanes playing an important role in maintaining dry forest structure in Puerto Rico. Hurricane disturbance simulations within ZELIG-TROP predicted that increasing hurricane intensity (i.e. up to 100% increase) did not lead to a large shift in long-term AGB or NPP. However, increased hurricane frequency did lead to a 5-40% decrease in AGB, and 32-50% increase in NPP, depending on the treatment. In addition, the modeling approach used

  20. A dynamic programming model for optimal planning of aquifer storage and recovery facility operations

    Science.gov (United States)

    Uddameri, V.

    2007-01-01

    Aquifer storage recovery (ASR) is an innovative technology with the potential to augment dwindling water resources in regions experiencing rapid growth and development. Planning and design of ASR systems requires quantifying how much water should be stored and appropriate times for storage and withdrawals within a planning period. A monthly scale planning model has been developed in this study to derive optimal (least cost) long-term policies for operating ASR systems and is solved using a recursive deterministic dynamic programming approach. The outputs of the model include annual costs of operation, the amount of water to be imported each month as well as the schedule for storage and extraction. A case study modeled after a proposed ASR system for Mustang Island and Padre Island service areas of the city of Corpus Christi is used to illustrate the utility of the developed model. The results indicate that for the assumed baseline demands, the ASR system is to be kept operational for a period of 4 months starting from May through August. Model sensitivity analysis indicated that increased seasonal shortages can be met using ASR with little additional costs. For the assumed cost structure, a 16% shortage increased the costs by 1.6%. However, the operation time of ASR increased from 4 to 8 months. The developed dynamic programming model is a useful tool to assess the feasibility of evaluating the use of ASR systems during regional-scale water resources planning endeavors.

  1. A multi-scale model for CO2 sequestration enhanced coalbed methane recovery

    Institute of Scientific and Technical Information of China (English)

    G.X.WANG; X.R.WEI; V.RUDOLPH; C.T.WEI; Y.QIN

    2009-01-01

    This paper presents a multi-scale model to simulate the multicomponent gas diffusion and flow in bulk coals for CO2 sequestration enhanced coalbed methane recovery. The model is developed based on a bi-dispersed structure model by assuming that coal con-sists of microporous micro-particles, meso/macro-pores and open microfractures. The bi-disperse diffusion theory and the Maxwell-Stefan approach were incorporated in the model, providing an improved simulation of the CH4-CO2/CH4-N2 counter diffusion dynamics. In the model,the counter diffusion process is numerically coupled with the flow of the mixture gases occurring within macro-pores or fractures in coal so as to account for the interaction between diffusion and flow in gas transport through coals.The model was validated by both experimental data from literature and our CO2 flush tests, and shows an excellent agreement with the experiments. The results reveal that the gas diffusivities, in particular the micro-pore diffusivities are strongly concentration-dependent.

  2. Application of the GEM Inventory Data Capture Tools for Dynamic Vulnerability Assessment and Recovery Modelling

    Science.gov (United States)

    Verrucci, Enrica; Bevington, John; Vicini, Alessandro

    2014-05-01

    A set of open-source tools to create building exposure datasets for seismic risk assessment was developed from 2010-13 by the Inventory Data Capture Tools (IDCT) Risk Global Component of the Global Earthquake Model (GEM). The tools were designed to integrate data derived from remotely-sensed imagery, statistically-sampled in-situ field data of buildings to generate per-building and regional exposure data. A number of software tools were created to aid the development of these data, including mobile data capture tools for in-field structural assessment, and the Spatial Inventory Data Developer (SIDD) for creating "mapping schemes" - statistically-inferred distributions of building stock applied to areas of homogeneous urban land use. These tools were made publically available in January 2014. Exemplar implementations in Europe and Central Asia during the IDCT project highlighted several potential application areas beyond the original scope of the project. These are investigated here. We describe and demonstrate how the GEM-IDCT suite can be used extensively within the framework proposed by the EC-FP7 project SENSUM (Framework to integrate Space-based and in-situ sENSing for dynamic vUlnerability and recovery Monitoring). Specifically, applications in the areas of 1) dynamic vulnerability assessment (pre-event), and 2) recovery monitoring and evaluation (post-event) are discussed. Strategies for using the IDC Tools for these purposes are discussed. The results demonstrate the benefits of using advanced technology tools for data capture, especially in a systematic fashion using the taxonomic standards set by GEM. Originally designed for seismic risk assessment, it is clear the IDCT tools have relevance for multi-hazard risk assessment. When combined with a suitable sampling framework and applied to multi-temporal recovery monitoring, data generated from the tools can reveal spatio-temporal patterns in the quality of recovery activities and resilience trends can be

  3. Coalescent Theory Analysis of Population Collapse and Recovery in a Neutral Evolution Model

    Science.gov (United States)

    King, Dawn; Bahar, Sonya

    As we move through the Anthropocene Epoch, human-driven climate change is predicted to accelerate extinction risk in the near future. Therefore, understanding basic underlying mechanisms of population loss and recovery could be paramount to saving key species in changing ecosystems. Here, we present an evolutionary model that investigates the dynamics of population collapse and recovery following a simulated mass extinction. Previously, we have shown that nonequilibrium, continuous phase transitions of the directed percolation universality class occur as a function of two different control parameters: the mutability, μ, which dictates how phenotypically different an offspring can be from its parent, and the death probability, δ, which probabilistically removes organisms within each generation. Here, we characterize the phylogenetic tree structures at two levels of biological organization--the organism and species level. Using methods from coalescent theory, we examine the phylogenetic tree structures at, and above, criticality, by considering common descent. The times to most recent common ancestor show phase transition behavior, as well as scale-free branching behavior at both levels of organization. We further examine these genealogical structures pre- and post-extinction. This research was supported by funding from the James S. McDonnell Foundation.

  4. Topographic Phase Recovery from Stacked ERS Interferometry and a Low-Resolution Digital Elevation Model

    Science.gov (United States)

    Sandwell, David T.; Sichoix, Lydie; Frey, Herbert V. (Technical Monitor)

    2000-01-01

    A hybrid approach to topographic recovery from ERS interferometry is developed and assessed. Tropospheric/ionospheric artifacts, imprecise orbital information, and layover are key issues in recovering topography and surface deformation from repeat-pass interferometry. Previously, we developed a phase gradient approach to stacking interferograms to reduce these errors and also to reduce the short-wavelength phase noise (see Sandwell arid Price [1998] and Appendix A). Here the method is extended to use a low-resolution digital elevation model to constrain long-wavelength phase errors and an iteration scheme to minimize errors in the computation of phase gradient. We demonstrate the topographic phase recovery on 16-m postings using 25 ERS synthetic aperture radar images from an area of southern California containing 2700 m of relief. On the basis of a comparison with 81 GPS monuments, the ERS derived topography has a typical absolute accuracy of better than 10 m except in areas of layover. The resulting topographic phase enables accurate two-pass, real-time interferometry even in mountainous areas where traditional phase unwrapping schemes fail. As an example, we form a topography-free (127-m perpendicular baseline) interferogram spanning 7.5 years; fringes from two major earthquakes and a seismic slip on the San Andreas Fault are clearly isolated.

  5. Consumer-operated service program members' explanatory models of mental illness and recovery.

    Science.gov (United States)

    Hoy, Janet M

    2014-10-01

    Incorporating individuals' understandings and explanations of mental illness into service delivery offers benefits relating to increased service relevance and meaning. Existing research delineates explanatory models of mental illness held by individuals in home, outpatient, and hospital-based contexts; research on models held by those in peer-support contexts is notably absent. In this article, I describe themes identified within and across explanatory models of mental illness and recovery held by mental health consumers (N = 24) at one peer center, referred to as a consumer-operated service center (COSP). Participants held explanatory models inclusive of both developmental stressors and biomedical causes, consistent with a stress-diathesis model (although no participant explicitly referenced such). Explicit incorporation of stress-diathesis constructs into programming at this COSP offers the potential of increasing service meaning and relevance. Identifying and incorporating shared meanings across individuals' understandings of mental illness likewise can increase relevance and meaning for particular subgroups of service users. © The Author(s) 2014.

  6. Discrete Fracture Modeling of 3D Heterogeneous Enhanced Coalbed Methane Recovery with Prismatic Meshing

    Directory of Open Access Journals (Sweden)

    Yongbin Zhang

    2015-06-01

    Full Text Available In this study, a 3D multicomponent multiphase simulator with a new fracture characterization technique is developed to simulate the enhanced recovery of coalbed methane. In this new model, the diffusion source from the matrix is calculated using the traditional dual-continuum approach, while in the Darcy flow scale, the Discrete Fracture Model (DFM is introduced to explicitly represent the flow interaction between cleats and large-scale fractures. For this purpose, a general formulation is proposed to model the multicomponent multiphase flow through the fractured coal media. The S&D model and a revised P&M model are incorporated to represent the geomechanical effects. Then a finite volume based discretization and solution strategies are constructed to solve the general ECBM equations. The prismatic meshing algorism is used to construct the grids for 3D reservoirs with complex fracture geometry. The simulator is validated with a benchmark case in which the results show close agreement with GEM. Finally, simulation of a synthetic heterogeneous 3D coal reservoir modified from a published literature is performed to evaluate the production performance and the effects of injected gas composition, well pattern and gas buoyancy.

  7. Eos modeling and reservoir simulation study of bakken gas injection improved oil recovery in the elm coulee field, Montana

    Science.gov (United States)

    Pu, Wanli

    The Bakken Formation in the Williston Basin is one of the most productive liquid-rich unconventional plays. The Bakken Formation is divided into three members, and the Middle Bakken Member is the primary target for horizontal wellbore landing and hydraulic fracturing because of its better rock properties. Even with this new technology, the primary recovery factor is believed to be only around 10%. This study is to evaluate various gas injection EOR methods to try to improve on that low recovery factor of 10%. In this study, the Elm Coulee Oil Field in the Williston Basin was selected as the area of interest. Static reservoir models featuring the rock property heterogeneity of the Middle Bakken Member were built, and fluid property models were built based on Bakken reservoir fluid sample PVT data. By employing both compositional model simulation and Todd-Longstaff solvent model simulation methods, miscible gas injections were simulated and the simulations speculated that oil recovery increased by 10% to 20% of OOIP in 30 years. The compositional simulations yielded lower oil recovery compared to the solvent model simulations. Compared to the homogeneous model, the reservoir model featuring rock property heterogeneity in the vertical direction resulted in slightly better oil recovery, but with earlier CO2 break-through and larger CO2 production, suggesting that rock property heterogeneity is an important property for modeling because it has a big effect on the simulation results. Long hydraulic fractures shortened CO2 break-through time greatly and increased CO 2 production. Water-alternating-gas injection schemes and injection-alternating-shut-in schemes can provide more options for gas injection EOR projects, especially for gas production management. Compared to CO2 injection, separator gas injection yielded slightly better oil recovery, meaning separator gas could be a good candidate for gas injection EOR; lean gas generated the worst results. Reservoir

  8. Recovery of Graded Response Model Parameters: A Comparison of Marginal Maximum Likelihood and Markov Chain Monte Carlo Estimation

    Science.gov (United States)

    Kieftenbeld, Vincent; Natesan, Prathiba

    2012-01-01

    Markov chain Monte Carlo (MCMC) methods enable a fully Bayesian approach to parameter estimation of item response models. In this simulation study, the authors compared the recovery of graded response model parameters using marginal maximum likelihood (MML) and Gibbs sampling (MCMC) under various latent trait distributions, test lengths, and…

  9. Overcoming the slow recovery of MOX gas sensors through a system modeling approach.

    Science.gov (United States)

    Monroy, Javier G; González-Jiménez, Javier; Blanco, Jose Luis

    2012-10-11

    Metal Oxide Semiconductor (MOX) gas transducers are one of the preferable technologies to build electronic noses because of their high sensitivity and low price. In this paper we present an approach to overcome to a certain extent one of their major disadvantages: their slow recovery time (tens of seconds), which limits their suitability to applications where the sensor is exposed to rapid changes of the gas concentration. Our proposal consists of exploiting a double first-order model of the MOX-based sensor from which a steady-state output is anticipated in real time given measurements of the transient state signal. This approach assumes that the nature of the volatile is known and requires a precalibration of the system time constants for each substance, an issue that is also described in the paper. The applicability of the proposed approach is validated with several experiments in real, uncontrolled scenarios with a mobile robot bearing an e-nose.

  10. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL) for Clock Data Recovery (CDR)

    CERN Document Server

    Ashari, Zainab

    2012-01-01

    Modern communication and computer systems require rapid (Gbps), efficient and large bandwidth data transfers. Agressive scaling of digital integrated systems allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The Peripheral Component Interconnect Express (PCIe) protocol handles all communcation between the central processing unit (CPU) and hardware devices. PCIe buses require efficient clock data recovery circuits (CDR) to recover clock signals embedded in data during transmission. This paper describes the theoretical modeling and simulation of a phase-locked loop (PLL) used in a CDR circuit. A simple PLL architecture for a 5 GHz CDR circuit is proposed and elaborated in this work. Simulations were carried out using a Hardware Description Language, Verilog- AMS. The effect of jitter on the proposed design is also simulated and evaluated in this work. It was found that the proposed design is robust against both input and VCO jitter.

  11. Modeling and simulation of combined gas turbine engine and heat pipe system for waste heat recovery and utilization

    Energy Technology Data Exchange (ETDEWEB)

    Lamfon, N.J. [Saudi Aramco Jeddah Refinery, Jeddah (Saudi Arabia); Najjar, Y.S.H.; Akyurt, M. [King Abdulaziz Univ., Mechanical Engineering Dept., Jeddah (Saudi Arabia)

    1998-12-01

    The results of a modeling and simulation study are presented for a combined system consisting of a gas turbine engine, a heat pipe recovery system and an inlet-air cooling system. The presentation covers performance data related to the gas turbine engine with precooled air intake as coupled to the water-in-copper heat pipe recovery system. This is done by matching the two mathematical models. The net power output is improved by 11% when the gas turbine engine is supplied with cold air produced by the heat-pipe recovery and utilization system. It is further concluded from the results produced by the combined mathematical model that the thermal efficiency of the gas turbine engine rises to 6% at 75% part load. It is to be anticipated that this rising trend in increases of thermal efficiency of the gas turbine engine would continue for operations at other (lower) part load conditions. (author)

  12. Recovery in ERG gene expression with biventricular pacing in a rabbit model of myocardial infarction

    Directory of Open Access Journals (Sweden)

    Saba S

    2013-05-01

    Full Text Available Samir Saba,* Haider Mehdi,* William Barrington, Fardeen Mehdi, Zahid Islam, Barry LondonCardiovascular Institute of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA*These authors contributed equally to this workBackground: Improved clinical and echocardiographic parameters have been documented with biventricular (BIV pacing in patients after myocardial infarction (MI. We investigated the changes in gene expression in cardiac tissue with BIV pacing, using a rabbit model of MI.Method: New Zealand White rabbits were divided into four groups: sham-operated controls, MI with no pacing, MI with right ventricle (RV pacing (MI + RV, and MI with BIV pacing (MI + BIV. Pacing was initiated 1–2 weeks after the coronary ligation. At 5 weeks, the hearts were excised. The tissue extracted from the left ventricle (LV and RV underwent analysis for protein and messenger ribonucleic acid (mRNA levels.Results: The ether-a-go-go-related gene (ERG protein levels recovered from the base of the LV away from the MI area were two- to threefold lower in the MI and the MI + RV compared with the MI + BIV groups (P = 0.07. The ERG protein levels were similar between the MI + BIV and the control groups. However, the RNA levels were comparable between the four study groups, suggesting that a posttranscriptional mechanism accounted for the difference in protein levels.Conclusion: In this rabbit model of MI, we demonstrated a recovery in ERG protein levels with BIV pacing, after MI. This recovery may underlie some of the benefits seen with BIV pacing in ischemic cardiomyopathy.Keywords: heart failure, biventricular pacing, cardiac reverse remodeling, ether-a-go-go-related gene

  13. Artificial Neural Network Model to Estimate the Viscosity of Polymer Solutions for Enhanced Oil Recovery

    Directory of Open Access Journals (Sweden)

    Pan-Sang Kang

    2016-06-01

    Full Text Available Polymer flooding is now considered a technically- and commercially-proven method for enhanced oil recovery (EOR. The viscosity of the injected polymer solution is the key property for successful polymer flooding. Given that the viscosity of a polymer solution has a non-linear relationship with various influential parameters (molecular weight, degree of hydrolysis, polymer concentration, cation concentration of polymer solution, shear rate, temperature and that measurement of viscosity based on these parameters is a time-consuming process, the range of solution samples and the measurement conditions need to be limited and precise. Viscosity estimation of the polymer solution is effective for these purposes. An artificial neural network (ANN was applied to the viscosity estimation of FlopaamTM 3330S, FlopaamTM 3630S and AN-125 solutions, three commonly-used EOR polymers. The viscosities measured and estimated by ANN and the Carreau model using Lee’s correlation, the only method for estimating the viscosity of an EOR polymer solution in unmeasured conditions, were compared. Estimation accuracy was evaluated by the average absolute relative deviation, which has been widely used for accuracy evaluation of the results of ANN models. In all conditions, the accuracy of the ANN model is higher than that of the Carreau model using Lee’s correlation.

  14. Stable direction recovery in single-index models with a diverging number of predictors

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Large dimensional predictors are often introduced in regressions to attenuate the possible modeling bias. We consider the stable direction recovery in single-index models in which we solely assume the response Y is independent of the diverging dimensional predictors X when βτ 0 X is given, where β 0 is a p n × 1 vector, and p n →∞ as the sample size n →∞. We first explore sufficient conditions under which the least squares estimation β n0 recovers the direction β 0 consistently even when p n = o(√ n). To enhance the model interpretability by excluding irrelevant predictors in regressions, we suggest an e1-regularization algorithm with a quadratic constraint on magnitude of least squares residuals to search for a sparse estimation of β 0 . Not only can the solution β n of e1-regularization recover β 0 consistently, it also produces sufficiently sparse estimators which enable us to select "important" predictors to facilitate the model interpretation while maintaining the prediction accuracy. Further analysis by simulations and an application to the car price data suggest that our proposed estimation procedures have good finite-sample performance and are computationally efficient.

  15. Mathematical modelling of flux recovery during chemical cleaning of tubular membrane fouled with whey proteins

    Directory of Open Access Journals (Sweden)

    Marković Jelena Đ.

    2009-01-01

    Full Text Available Membrane process efficiency in the dairy industry is impaired by the formation of deposits during filtration processes. This work describes cleaning procedures for ceramic tubular membrane (50 nm fouled with whey proteins. Also, mathematical modelling was performed to obtain models which allow deeper insight into the mechanisms involved during cleaning procedures. The caustic solutions (0.2%w/w, 0.4%w/w and 1.0%w/w NaOH and the mixture of two commercial detergents (0.8%w/w P3-ultrasil 69+0.5% w/w P3-ultrasil 67 and 1.2% P3-ultrasil 69+0.75 P3-ultrasil 67 were used as chemical cleaning agents. The results showed that the best flux recovery was achieved with 0.4%w/w NaOH solution. After analyzing the experimental data, five parameter and six parameter kinetic models were suggested for alkali and detergent cleaning, respectively. The changes of total and specific resistances, as well as the change of the effective pore diameter and deposit thickness during cleaning are estimated by applying these models.

  16. Temperature model for process impact non-uniformity in genipin recovery by high pressure processing.

    Science.gov (United States)

    Ramos-de-la-Peña, Ana Mayela; Montañez, Julio C; Reyes-Vega, María de la Luz; Contreras-Esquivel, Juan Carlos

    2015-11-15

    A model for the process impact temperature non-uniformity during high pressure processing (HPP) of genipap fruit purees was found during genipin recovery. Purees were subjected to HPP (130-530 MPa) under quasi-isobaric non-isothermal conditions (15 min; 0, 4.6 and 9.3mg pectinases/g fruit). Genipin and protein concentration was determined, and pH was measured. Polygalacturonase activity was quantified indirectly by protein content (mg/g fruit). First order kinetics described temperature changes (0-4 min). Polygalacturonase was activated at 130 MPa, inactivated reversibly at 330 MPa and activated again at 530 MPa. Enzyme reaction rate constant (k) was placed in the 0-4 min model and temperature from 2 to 15 min was described. Protein content and pH characterization in terms of decimal reduction time improved highly the 2-15 min model. Since temperature changes were modeled, more insight of its behavior in an HPP reactor was obtained, avoiding uniformity assumptions, making easier the industrial scale HPP implementation.

  17. Modelling the effect of wettability distributions on oil recovery from microporous carbonate reservoirs

    Science.gov (United States)

    Kallel, W.; van Dijke, M. I. J.; Sorbie, K. S.; Wood, R.; Jiang, Z.; Harland, S.

    2016-09-01

    Carbonate-hosted hydrocarbon reservoirs are known to be weakly- to moderately oil-wet, but the pore-scale wettability distribution is poorly understood. Moreover, micropores, which often dominate in carbonate reservoirs, are usually assumed to be water-wet and their role in multi-phase flow is neglected. Modelling the wettability of carbonates using pore network models is challenging, because of our inability to attribute appropriate chemical characteristics to the pore surfaces and over-simplification of the pore shapes. Here, we implement a qualitatively plausible wettability alteration scenario in a two-phase flow network model that captures a diversity of pore shapes. The model qualitatively reproduces patterns of wettability alteration recently observed in microporous carbonates via high-resolution imaging. To assess the combined importance of pore-space structure and wettability on petrophysical properties, we consider a homogeneous Berea sandstone network and a heterogeneous microporous carbonate network, whose disconnected coarse-scale pores are connected through a sub-network of fine-scale pores. Results demonstrate that wettability effects are significantly more profound in the carbonate network, as the wettability state of the micropores controls the oil recovery.

  18. A model for recovery of scrap monolithic uranium molybdenum fuel by electrorefining

    Science.gov (United States)

    Van Kleeck, Melissa A.

    The goal of the Reduced Enrichment for Research and Test Reactors program (RERTR) is toreduce enrichment at research and test reactors, thereby decreasing proliferation risk at these facilities. A new fuel to accomplish this goal is being manufactured experimentally at the Y12 National Security Complex. This new fuel will require its own waste management procedure,namely for the recovery of scrap from its manufacture. The new fuel is a monolithic uraniummolybdenum alloy clad in zirconium. Feasibility tests were conducted in the Planar Electrode Electrorefiner using scrap U-8Mo fuel alloy. These tests proved that a uranium product could be recovered free of molybdenum from this scrap fuel by electrorefining. Tests were also conducted using U-10Mo Zr clad fuel, which confirmed that product could be recovered from a clad version of this scrap fuel at an engineering scale, though analytical results are pending for the behavior of Zr in the electrorefiner. A model was constructed for the simulation of electrorefining the scrap material produced in the manufacture of this fuel. The model was implemented on two platforms, Microsoft Excel and MatLab. Correlations, used in the model, were developed experimentally, describing area specific resistance behavior at each electrode. Experiments validating the model were conducted using scrap of U-10Mo Zr clad fuel in the Planar Electrode Electrorefiner. The results of model simulations on both platforms were compared to experimental results for the same fuel, salt and electrorefiner compositions and dimensions for two trials. In general, the model demonstrated behavior similar to experimental data but additional refinements are needed to improve its accuracy. These refinements consist of a function for surface area at anode and cathode based on charge passed. Several approximations were made in the model concerning areas of electrodes which should be replaced by a more accurate function describing these areas.

  19. Recovery Swaps

    OpenAIRE

    Berd, Arthur M.

    2010-01-01

    We derive an arbitrage free relationship between recovery swap rates, digital default swap spreads and conventional CDS spreads, and argue that the fair forward recovery rate used in recovery swaps must contain a convexity premium over the expected recovery value.

  20. Modeling and Control of a Parallel Waste Heat Recovery System for Euro-VI Heavy-Duty Diesel Engines

    Directory of Open Access Journals (Sweden)

    Emanuel Feru

    2014-10-01

    Full Text Available This paper presents the modeling and control of a waste heat recovery systemfor a Euro-VI heavy-duty truck engine. The considered waste heat recovery system consists of two parallel evaporators with expander and pumps mechanically coupled to the engine crankshaft. Compared to previous work, the waste heat recovery system modeling is improved by including evaporator models that combine the finite difference modeling approach with a moving boundary one. Over a specific cycle, the steady-state and dynamic temperature prediction accuracy improved on average by 2% and 7%. From a control design perspective, the objective is to maximize the waste heat recovery system output power.However, for safe system operation, the vapor state needs to be maintained before the expander under highly dynamic engine disturbances. To achieve this, a switching model predictive control strategy is developed. The proposed control strategy performance is demonstrated using the high-fidelity waste heat recovery system model subject to measured disturbances from an Euro-VI heavy-duty diesel engine. Simulations are performed usinga cold-start World Harmonized Transient cycle that covers typical urban, rural and highway driving conditions. The model predictive control strategy provides 15% more time in vaporand recovered thermal energy than a classical proportional-integral (PI control strategy. In the case that the model is accurately known, the proposed control strategy performance can be improved by 10% in terms of time in vapor and recovered thermal energy. This is demonstrated with an offline nonlinear model predictive control strategy.

  1. An LCA model for waste incineration enhanced with new technologies for metal recovery and application to the case of Switzerland.

    Science.gov (United States)

    Boesch, Michael E; Vadenbo, Carl; Saner, Dominik; Huter, Christoph; Hellweg, Stefanie

    2014-02-01

    A process model of municipal solid waste incinerators (MSWIs) and new technologies for metal recovery from combustion residues was developed. The environmental impact is modeled as a function of waste composition as well as waste treatment and material recovery technologies. The model includes combustion with a grate incinerator, several flue gas treatment technologies, electricity and steam production from waste heat recovery, metal recovery from slag and fly ash, and landfilling of residues and can be tailored to specific plants and sites (software tools can be downloaded free of charge). Application of the model to Switzerland shows that the treatment of one tonne of municipal solid waste results on average in 425 kg CO2-eq. generated in the incineration process, and 54 kg CO2-eq. accrue in upstream processes such as waste transport and the production of operating materials. Downstream processes, i.e. residue disposal, generates 5 kg CO2-eq. Savings from energy recovery are in the range of 67 to 752 kg CO2-eq. depending on the assumptions regarding the substituted energy production, while the recovery of metals from slag and fly ash currently results in a net saving of approximately 35 kg CO2-eq. A similar impact pattern is observed when assessing the MSWI model for aggregated environmental impacts (ReCiPe) and for non-renewable resource consumption (cumulative exergy demand), except that direct emissions have less and no relevance, respectively, on the total score. The study illustrates that MSWI plants can be an important element of industrial ecology as they provide waste disposal services and can help to close material and energetic cycles.

  2. Potential Spermatogenesis Recovery with Bone Marrow Mesenchymal Stem Cells in an Azoospermic Rat Model

    Directory of Open Access Journals (Sweden)

    Deying Zhang

    2014-07-01

    Full Text Available Non-obstructive azoospermia is the most challenging type of male infertility. Stem cell based therapy provides the potential to enhance the recovery of spermatogenesis following cancer therapy. Bone marrow-derived mesenchymal stem cells (BMSCs possess the potential to differentiate or trans-differentiate into multi-lineage cells, secrete paracrine factors to recruit the resident stem cells to participate in tissue regeneration, or fuse with the local cells in the affected region. In this study, we tested whether spermatogenically-induced BMSCs can restore spermatogenesis after administration of an anticancer drug. Allogeneic BMSCs were co-cultured in conditioned media derived from cultured testicular Sertoli cells in vitro, and then induced stem cells were transplanted into the seminiferous tubules of a busulfan-induced azoospermatic rat model for 8 weeks. The in vitro induced BMSCs exhibited specific spermatogonic gene and protein markers, and after implantation the donor cells survived and located at the basement membranes of the recipient seminiferous tubules, in accordance with what are considered the unique biological characteristics of spermatogenic stem cells. Molecular markers of spermatogonial stem cells and spermatogonia (Vasa, Stella, SMAD1, Dazl, GCNF, HSP90α, integrinβ1, and c-kit were expressed in the recipient testis tissue. No tumor mass, immune response, or inflammatory reaction developed. In conclusion, BMSCs might provide the potential to trans-differentiate into spermatogenic-like-cells, enhancing endogenous fertility recovery. The present study indicates that BMSCs might offer alternative treatment for the patients with azoospermatic infertility after cancer chemotherapy.

  3. Black liquor combustion validated recovery boiler modeling: Final year report. Volume 3 (Appendices II, sections 2--3 and III)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1998-08-01

    This project was initiated in October 1990, with the objective of developing and validating a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The key tasks to be accomplished were as follows: (1) Complete the development of enhanced furnace models that have the capability to accurately predict carryover, emissions behavior, dust concentrations, gas temperatures, and wall heat fluxes. (2) Validate the enhanced furnace models, so that users can have confidence in the predicted results. (3) Obtain fundamental information on aerosol formation, deposition, and hardening so as to develop the knowledge base needed to relate furnace model outputs to plugging and fouling in the convective sections of the boiler. (4) Facilitate the transfer of codes, black liquid submodels, and fundamental knowledge to the US kraft pulp industry. Volume 3 contains the following appendix sections: Formation and destruction of nitrogen oxides in recovery boilers; Sintering and densification of recovery boiler deposits laboratory data and a rate model; and Experimental data on rates of particulate formation during char bed burning.

  4. A semi-analytical model for predicting water quality from an aquifer storage and recovery system

    Science.gov (United States)

    Sedighi, Ali; Klammler, Harald; Brown, Chris; Hatfield, Kirk

    2006-10-01

    SummaryAquifer storage and recovery (ASR) involves the injection of freshwater in an aquifer through wells for the purpose of creating a subsurface water supply that is recovered at a later time, often using the same wells, to meet seasonal, long-term, emergency, or other demands. In this paper a numerically efficient semi-analytical model is developed for predicting the quality of water recovered by an ASR system given data on the qualities of ambient and injected waters, hydraulic properties of the aquifer, ambient hydraulic gradient, and system operations. It is assumed the ASR well is installed in a stratified aquifer such that the semi-analytical ASR model (SASRM) simulates the fate of water injected under steady-state conditions into each stratum. It is also assumed that a sharp and mobile interface separates injected water from ambient groundwater such that in situ mixing of water within and between strata does not occur. SASRM assigns particles to define the location the interface in all strata and then follows the migration of these particles under ambient and induced flow conditions. During water recovery, the transient location of the interface is simulated in each stratum and this information is used to quantify the fractions of ambient and injected water extracted at the well-head and the quality of water recovered. To mimic the effects of dispersion, a Latin Hypercube sampling strategy is used to assign hydraulic conductivities according to a predefined probability distribution to the layers of a conceptually stratified aquifer. The volumetric fraction of water received or delivered from any given lithologic unit is assumed proportional to the transmissivity of the stratum normalized to the total aquifer transmissivity interrogated by the ASR well. SARSM is numerically verified against MT3DMS and then calibrated and validated using field data from an ASR system located in Boynton Beach, FL. The field demonstration shows SASRM is capable of predicting

  5. A novel, recovery, and reproducible minimally invasive cardiopulmonary bypass model with lung injury in rats

    Institute of Scientific and Technical Information of China (English)

    LI Ling-ke; CHENG Wei; LIU Dong-hai; ZHANG Jing; ZHU Yao-bin; QIAO Chen-hui; ZHANG Yan-bo

    2013-01-01

    Background Cardiopulmonary bypass (CPB) has been shown to be associated with a systemic inflammatory response leading to postoperative organ dysfunction.Elucidating the underlying mechanisms and developing protective strategies for the pathophysiological consequences of CPB have been hampered due to the absence of a satisfactory recovery animal model.The purpose of this study was to establish a good rat model of CPB to study the pathophysiology of potential complications.Methods Twenty adult male Sprague-Dawley rats weighing 450-560 g were randomly divided into a CPB group (n=10)and a control group (n=10).All rats were anaesthetized and mechanically ventilated.The carotid artery and jugular vein were cannulated.The blood was drained from the dght atrium via the right jugular and transferred by a miniaturized roller pump to a hollow fiber oxygenator and back to the rat via the left carotid artery.Priming consisted of 8 ml of homologous blood and 8 ml of colloid.The surface of the hollow fiber oxygenator was 0.075 m2.CPB was conducted for 60 minutes at a flow rate of 100-120 ml.kg-1.min-1 in the CPB group.Oxygen flow/perfusion flow was 0.8 to 1.0,and the mean arterial pressure remained 60-80 mmHg.Blood gas analysis,hemodynamic investigations,and lung histology were subsequently examined.Results All CPB rats recovered from the operative process without incident.Normal cardiac function after successful weaning was confirmed by electrocardiography and blood pressure measurements.Mean arterial pressure remained stable.The results of blood gas analysis at different times were within the normal range.Levels of IL-1β and TNF-α were higher in the lung tissue in the CPB group (P <0.005).Histological examination revealed marked increases in interstitial congestion,edema,and inflammation in the CPB group.Conclusion This novel,recovery,and reproducible minimally invasive CPB model may open the field for various studies on the pathophysiological process of CPB and systemic

  6. Synthetic aperture radar imaging based on attributed scatter model using sparse recovery techniques

    Institute of Scientific and Technical Information of China (English)

    苏伍各; 王宏强; 阳召成

    2014-01-01

    The sparse recovery algorithms formulate synthetic aperture radar (SAR) imaging problem in terms of sparse representation (SR) of a small number of strong scatters’ positions among a much large number of potential scatters’ positions, and provide an effective approach to improve the SAR image resolution. Based on the attributed scatter center model, several experiments were performed with different practical considerations to evaluate the performance of five representative SR techniques, namely, sparse Bayesian learning (SBL), fast Bayesian matching pursuit (FBMP), smoothed l0 norm method (SL0), sparse reconstruction by separable approximation (SpaRSA), fast iterative shrinkage-thresholding algorithm (FISTA), and the parameter settings in five SR algorithms were discussed. In different situations, the performances of these algorithms were also discussed. Through the comparison of MSE and failure rate in each algorithm simulation, FBMP and SpaRSA are found suitable for dealing with problems in the SAR imaging based on attributed scattering center model. Although the SBL is time-consuming, it always get better performance when related to failure rate and high SNR.

  7. Assessment of recovery from ocular irritancy using a human tissue equivalent model.

    Science.gov (United States)

    Espersen, R J; Olsen, P; Nicolaisen, G M; Jensen, B L; Rasmussen, E S

    1997-01-01

    The SKIN(2) ZK1200 tissue equivalent model has been used in an exploratory study of recovery from ocular irritation. Nine substances from the ECETOC eye irritation reference chemicals data bank were tested. The cellular viability of the tissue model was measured using the MTT assay immediately after chemical exposure and after incubation periods corresponding to observation times used in the Draize tests. The cellular viability of the tissue specimens exposed to moderate irritants, with modified maximum average score (MMAS) values between 15 and 40 (= 5), returned to control levels within 1-7 days. Tissue specimens exposed to 1 and 10% benzalkonium chloride showed significantly reduced MTT activities at day 14 and day 21. Mild ocular irritants, with MMAS values below 3 (n = 2), did not induce significant depressions of the MTT activities of the tissue specimens after 60 min exposure. A relatively good correlation (r = 0.73) was obtained between the exposure times used in vitro and Draize MMAS values. Moreover, the incubation periods needed for the exposed SKIN(2) ZK1200 to regain control MTT activities showed a good agreement (r > 0.90) with days-to-clear ocular irritancy in the Draize test.

  8. Modelling plastic deformation in BCC metals: Dynamic recovery and cell formation effects

    Energy Technology Data Exchange (ETDEWEB)

    Galindo-Nava, E.I. [Department of Materials Science and Metallurgy, Pembroke Street, CB2 3QZ, University of Cambridge, Cambridge (United Kingdom); Department of Materials Science and Engineering, Mekelweg 2 2628 CD, Delft University of Technology, Delft (Netherlands); Rivera-Diaz-del-Castillo, P.E.J., E-mail: pejr2@cam.ac.uk [Department of Materials Science and Metallurgy, Pembroke Street, CB2 3QZ, University of Cambridge, Cambridge (United Kingdom)

    2012-12-15

    A recently developed model for describing plasticity in FCC metals (E.I., Galindo-Nava, P.E.J., Rivera-Diaz-del-Castillo, Mater. Sci. Eng. A 543 (2012) 110-116; E.I. Galindo-Nava, P.E.J. Rivera-Diaz-del-Castillo, Acta Mater. 60 (2012) 4370-4378) has now been applied to BCC. The core of the theory is the thermostatistical description of dislocation annihilation paths, which determines the dynamic recovery rate of the material. Input to this is the energy for the formation, migration and ordering of dislocation paths; the latter term corresponds to the statistical entropy which features strongly on the solution. The distinctions between FCC and BCC stem primarily from the possible directions and planes for dislocation slip and cross-slip, as well as from the presence of the kink-pair mechanism for dislocation migration in BCC, which are incorporated to the mathematical formulation of the model. The theory is unique in describing the stress-strain response for pure iron, molybdenum, tantalum, vanadium and tungsten employing physical parameters as input; the description is made for wide ranges of temperature and strain rate. Additionally, succinct equations to predict dislocation cell size variation with strain, strain rate and temperature are provided and validated for pure iron.

  9. Failure-recovery model with competition between failures in complex networks: a dynamical approach

    CERN Document Server

    Valdez, L D; Braunstein, L A

    2016-01-01

    Real systems are usually composed by units or nodes whose activity can be interrupted and restored intermittently due to complex interactions not only with the environment, but also with the same system. Majdand\\v{z}i\\'c $et\\;al.$ [Nature Physics 10, 34 (2014)] proposed a model to study systems in which active nodes fail and recover spontaneously in a complex network and found that in the steady state the density of active nodes can exhibit an abrupt transition and hysteresis depending on the values of the parameters. Here we investigate a model of recovery-failure from a dynamical point of view. Using an effective degree approach we find that the systems can exhibit a temporal sharp decrease in the fraction of active nodes. Moreover we show that, depending on the values of the parameters, the fraction of active nodes has an oscillatory regime which we explain as a competition between different failure processes. We also find that in the non-oscillatory regime, the critical fraction of active nodes presents a...

  10. Integrating Predictive Modeling with Control System Design for Managed Aquifer Recharge and Recovery Applications

    Science.gov (United States)

    Drumheller, Z. W.; Regnery, J.; Lee, J. H.; Illangasekare, T. H.; Kitanidis, P. K.; Smits, K. M.

    2014-12-01

    Aquifers around the world show troubling signs of irreversible depletion and seawater intrusion as climate change, population growth, and urbanization led to reduced natural recharge rates and overuse. Scientists and engineers have begun to re-investigate the technology of managed aquifer recharge and recovery (MAR) as a means to increase the reliability of the diminishing and increasingly variable groundwater supply. MAR systems offer the possibility of naturally increasing groundwater storage while improving the quality of impaired water used for recharge. Unfortunately, MAR systems remain wrought with operational challenges related to the quality and quantity of recharged and recovered water stemming from a lack of data-driven, real-time control. Our project seeks to ease the operational challenges of MAR facilities through the implementation of active sensor networks, adaptively calibrated flow and transport models, and simulation-based meta-heuristic control optimization methods. The developed system works by continually collecting hydraulic and water quality data from a sensor network embedded within the aquifer. The data is fed into an inversion algorithm, which calibrates the parameters and initial conditions of a predictive flow and transport model. The calibrated model is passed to a meta-heuristic control optimization algorithm (e.g. genetic algorithm) to execute the simulations and determine the best course of action, i.e., the optimal pumping policy for current aquifer conditions. The optimal pumping policy is manually or autonomously applied. During operation, sensor data are used to assess the accuracy of the optimal prediction and augment the pumping strategy as needed. At laboratory-scale, a small (18"H x 46"L) and an intermediate (6'H x 16'L) two-dimensional synthetic aquifer were constructed and outfitted with sensor networks. Data collection and model inversion components were developed and sensor data were validated by analytical measurements.

  11. Modeling the contribution of toxicokinetic and toxicodynamic processes to the recovery of Gammarus pulex populations after exposure to pesticides.

    Science.gov (United States)

    Galic, Nika; Ashauer, Roman; Baveco, Hans; Nyman, Anna-Maija; Barsi, Alpar; Thorbek, Pernille; Bruns, Eric; Van den Brink, Paul J

    2014-07-01

    Because aquatic macroinvertebrates may be exposed regularly to pesticides in edge-of-the-field water bodies, an accurate assessment of potential adverse effects and subsequent population recovery is essential. Standard effect risk assessment tools are not able to fully address the complexities arising from multiple exposure patterns, nor can they properly address the population recovery process. In the present study, we developed an individual-based model of the freshwater amphipod Gammarus pulex to evaluate the consequences of exposure to 4 compounds with different modes of action on individual survival and population recovery. Effects on survival were calculated using concentration-effect relationships and the threshold damage model (TDM), which accounts for detailed processes of toxicokinetics and toxicodynamics. Delayed effects as calculated by the TDM had a significant impact on individual survival and population recovery. We also evaluated the standard assessment of effects after short-term exposures using the 96-h concentration-effect model and the TDM, which was conservative for very short-term exposure. An integration of a TKTD submodel with a population model can be used to explore the ecological relevance of ecotoxicity endpoints in different exposure environments. © 2014 SETAC.

  12. Predicting long-term recovery of a strongly acidified stream using MAGIC and climate models (Litavka, Czech Republic

    Directory of Open Access Journals (Sweden)

    D. W. Hardekopf

    2007-09-01

    Full Text Available Two branches forming the headwaters of a stream in the Czech Republic were studied. Both streams have similar catchment characteristics and historical deposition; however one is rain-fed and strongly affected by acid atmospheric deposition, the other spring-fed and only moderately acidified. The MAGIC model was used to reconstruct past stream water and soil chemistry of the rain-fed branch, and predict future recovery up to 2050 under current proposed emissions levels. A future increase in air temperature calculated by a regional climate model was then used to derive climate-related scenarios to test possible factors affecting chemical recovery up to 2100. Macroinvertebrates were sampled from both branches, and differences in stream chemistry were reflected in the community structures. According to modelled forecasts, recovery of the rain-fed branch will be gradual and limited, and continued high levels of sulphate release from the soils will continue to dominate stream water chemistry, while scenarios related to a predicted increase temperature will have little impact. The likelihood of colonization of species from the spring-fed branch was evaluated considering the predicted extent of chemical recovery. The results suggest that the possibility of colonization of species from the spring-fed branch to the rain-fed will be limited to only the acid-tolerant stonefly, caddisfly and dipteran taxa in the modelled period.

  13. Predicting long-term recovery of a strongly acidified stream using MAGIC and climate models (Litavka, Czech Republic

    Directory of Open Access Journals (Sweden)

    D. W. Hardekopf

    2008-03-01

    Full Text Available Two branches forming the headwaters of a stream in the Czech Republic were studied. Both streams have similar catchment characteristics and historical deposition; however one is rain-fed and strongly affected by acid atmospheric deposition, the other spring-fed and only moderately acidified. The MAGIC model was used to reconstruct past stream water and soil chemistry of the rain-fed branch, and predict future recovery up to 2050 under current proposed emissions levels. A future increase in air temperature calculated by a regional climate model was then used to derive climate-related scenarios to test possible factors affecting chemical recovery up to 2100. Macroinvertebrates were sampled from both branches, and differences in stream chemistry were reflected in the community structures. According to modelled forecasts, recovery of the rain-fed branch will be gradual and limited, and continued high levels of sulphate release from the soils will continue to dominate stream water chemistry, while scenarios related to a predicted increase in temperature will have little impact. The likelihood of colonization of species from the spring-fed branch was evaluated considering the predicted extent of chemical recovery. The results suggest that the possibility of colonization of species from the spring-fed branch to the rain-fed will be limited to only the acid-tolerant stonefly, caddisfly and dipteran taxa in the modelled period.

  14. A Systematic Review of Exercise Training To Promote Locomotor Recovery in Animal Models of Spinal Cord Injury

    Science.gov (United States)

    Callister, Robert J.; Callister, Robin; Galea, Mary P.

    2012-01-01

    Abstract In the early 1980s experiments on spinalized cats showed that exercise training on the treadmill could enhance locomotor recovery after spinal cord injury (SCI). In this review, we summarize the evidence for the effectiveness of exercise training aimed at promoting locomotor recovery in animal models of SCI. We performed a systematic search of the literature using Medline, Web of Science, and Embase. Of the 362 studies screened, 41 were included. The adult female rat was the most widely used animal model. The majority of studies (73%) reported that exercise training had a positive effect on some aspect of locomotor recovery. Studies employing a complete SCI were less likely to have positive outcomes. For incomplete SCI models, contusion was the most frequently employed method of lesion induction, and the degree of recovery depended on injury severity. Positive outcomes were associated with training regimens that involved partial weight-bearing activity, commenced within a critical period of 1–2 weeks after SCI, and maintained training for at least 8 weeks. Considerable heterogeneity in training paradigms and methods used to assess or quantify recovery was observed. A 13-item checklist was developed and employed to assess the quality of reporting and study design; only 15% of the studies had high methodological quality. We recommend that future studies include control groups, randomize animals to groups, conduct blinded assessments, report the extent of the SCI lesion, and report sample size calculations. A small battery of objective assessment methods including assessment of over-ground stepping should also be developed and routinely employed. This would allow future meta-analyses of the effectiveness of exercise interventions on locomotor recovery. PMID:22401139

  15. An LCA model for waste incineration enhanced with new technologies for metal recovery and application to the case of Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Boesch, Michael E. [Aveny GmbH, Schwandenholzstr. 212, CH-8046 Zürich (Switzerland); Vadenbo, Carl, E-mail: vadenbo@ifu.baug.ethz.ch [ETH Zurich, Institute of Environmental Engineering, Schafmattstrasse 6, CH-8093 Zurich (Switzerland); Saner, Dominik [Swiss Post, Communications, Politics and Social Responsibility, Viktoriastrasse 21, P.O. Box, CH-3030 Berne (Switzerland); Huter, Christoph [City of Zürich, ERZ Entsorgung - Recycling Zürich, Hagenholzstrasse 110, P.O. Box, CH-8050 Zürich (Switzerland); Hellweg, Stefanie [ETH Zurich, Institute of Environmental Engineering, Schafmattstrasse 6, CH-8093 Zurich (Switzerland)

    2014-02-15

    Highlights: • An enhanced process-based LCA model for MSWI is featured and applied in case study. • LCA modeling of recent technological developments for metal recovery from fly ash. • Net release from Swiss MSWI 133 kg CO{sub 2}-eq/tonne waste from attributional LCA perspective. • Net savings from a consequential LCA perspective reach up to 303 kg CO{sub 2}-eq/tonne waste. • Impacts according to ReCiPe and CExD show similar pattern to climate change. - Abstract: A process model of municipal solid waste incinerators (MSWIs) and new technologies for metal recovery from combustion residues was developed. The environmental impact is modeled as a function of waste composition as well as waste treatment and material recovery technologies. The model includes combustion with a grate incinerator, several flue gas treatment technologies, electricity and steam production from waste heat recovery, metal recovery from slag and fly ash, and landfilling of residues and can be tailored to specific plants and sites (software tools can be downloaded free of charge). Application of the model to Switzerland shows that the treatment of one tonne of municipal solid waste results on average in 425 kg CO{sub 2}-eq. generated in the incineration process, and 54 kg CO{sub 2}-eq. accrue in upstream processes such as waste transport and the production of operating materials. Downstream processes, i.e. residue disposal, generates 5 kg CO{sub 2}-eq. Savings from energy recovery are in the range of 67 to 752 kg CO{sub 2}-eq. depending on the assumptions regarding the substituted energy production, while the recovery of metals from slag and fly ash currently results in a net saving of approximately 35 kg CO{sub 2}-eq. A similar impact pattern is observed when assessing the MSWI model for aggregated environmental impacts (ReCiPe) and for non-renewable resource consumption (cumulative exergy demand), except that direct emissions have less and no relevance, respectively, on the total

  16. Guidelines for Professional Referral to Alcoholics Anonymous and Other Twelve Step Groups.

    Science.gov (United States)

    Riordan, Richard J.; Walsh, Lani

    1994-01-01

    Reviews 12-step programs, focusing on Alcoholics Anonymous (AA), the oldest and largest 12-step group. Explores criticisms of AA, describes its components and mechanics, and provides guidelines for client referral. Includes 28 citations. (Author/CRR)

  17. Prognosis of patients with whiplash-associated disorders consulting physiotherapy: development of a predictive model for recovery

    Directory of Open Access Journals (Sweden)

    Bohman Tony

    2012-12-01

    Full Text Available Abstract Background Patients with whiplash-associated disorders (WAD have a generally favourable prognosis, yet some develop longstanding pain and disability. Predicting who will recover from WAD shortly after a traffic collision is very challenging for health care providers such as physical therapists. Therefore, we aimed to develop a prediction model for the recovery of WAD in a cohort of patients who consulted physical therapists within six weeks after the injury. Methods Our cohort included 680 adult patients with WAD who were injured in Saskatchewan, Canada, between 1997 and 1999. All patients had consulted a physical therapist as a result of the injury. Baseline prognostic factors were collected from an injury questionnaire administered by Saskatchewan Government Insurance. The outcome, global self-perceived recovery, was assessed by telephone interviews six weeks, three and six months later. Twenty-five possible baseline prognostic factors were considered in the analyses. A prediction model was built using Cox regression. The predictive ability of the model was estimated with concordance statistics (c-index. Internal validity was checked using bootstrapping. Results Our final prediction model included: age, number of days to reporting the collision, neck pain intensity, low back pain intensity, pain other than neck and back pain, headache before collision and recovery expectations. The model had an acceptable level of predictive ability with a c-index of 0.68 (95% CI: 0.65, 0.71. Internal validation showed that our model was robust and had a good fit. Conclusions We developed a model predicting recovery from WAD, in a cohort of patients who consulted physical therapists. Our model has adequate predictive ability. However, to be fully incorporated in clinical practice the model needs to be validated in other populations and tested in clinical settings.

  18. DNAPL accumulation in wells and DNAPL recovery from wells: Model development and application to a laboratory study

    Science.gov (United States)

    Sleep, Brent E.; Beranger, Sandra; Reinecke, Stefan; Filion, Yves

    2015-11-01

    Dense nonaqueous phase liquid (DNAPL) accumulation and recovery from wells cannot be accurately modeled through typical pressure or flux boundary conditions due to gravity segregation of water and DNAPL in the wellbore, the effects of wellbore storage, and variations of wellbore inflow and outflow rates with depth, particularly in heterogeneous formations. A discrete wellbore formulation is presented for numerical modeling of DNAPL accumulation in observation wells and DNAPL removal from recovery wells. The formulation includes fluid segregation, changing water and DNAPL levels in the well and the corresponding changes in fluid storage in the wellbore. The method was added to a three-dimensional finite difference model (CompSim) for three phase (water, gas, DNAPL) flow. The model predictions are compared to three-dimensional pilot scale experiments of DNAPL (benzyl alcohol) infiltration, redistribution, recovery, and water flushing. Model predictions match experimental results well, indicating the appropriateness of the model formulation. Characterization of mixing in the extraction well is important for predicting removal of highly soluble organic compounds like benzyl alcohol. A sensitivity analysis shows that the incorporation of hysteresis is critical for accurate prediction. Among the multiphase flow and transport parameters required for modeling, results are most sensitive to soil intrinsic permeability.

  19. Compression-recovery model of absorptive glass mat (AGM) separator guided by X-ray micro-computed tomography analysis

    Science.gov (United States)

    Kameswara Rao, P. V.; Rawal, Amit; Kumar, Vijay; Rajput, Krishn Gopal

    2017-10-01

    Absorptive glass mat (AGM) separators play a key role in enhancing the cycle life of the valve regulated lead acid (VRLA) batteries by maintaining the elastic characteristics under a defined level of compression force with the plates of the electrodes. Inevitably, there are inherent challenges to maintain the required level of compression characteristics of AGM separators during the charge and discharge of the battery. Herein, we report a three-dimensional (3D) analytical model for predicting the compression-recovery behavior of AGM separators by formulating a direct relationship with the constituent fiber and structural parameters. The analytical model of compression-recovery behavior of AGM separators has successfully included the fiber slippage criterion and internal friction losses. The presented work uses, for the first time, 3D data of fiber orientation from X-ray micro-computed tomography, for predicting the compression-recovery behavior of AGM separators. A comparison has been made between the theoretical and experimental results of compression-recovery behavior of AGM samples with defined fiber orientation characteristics. In general, the theory agreed reasonably well with the experimental results of AGM samples in both dry and wet states. Through theoretical modeling, fiber volume fraction was established as one of the key structural parameters that modulates the compression hysteresis of an AGM separator.

  20. Integrated Energy and Emission Management for Diesel Engines with Waste Heat Recovery Using Dynamic Models

    Directory of Open Access Journals (Sweden)

    Willems Frank

    2015-01-01

    Full Text Available Rankine-cycle Waste Heat Recovery (WHR systems are promising solutions to reduce fuel consumption for trucks. Due to coupling between engine and WHR system, control of these complex systems is challenging. This study presents an integrated energy and emission management strategy for an Euro-VI Diesel engine with WHR system. This Integrated Powertrain Control (IPC strategy optimizes the CO2-NOx trade-off by minimizing online the operational costs associated with fuel and AdBlue consumption. Contrary to other control studies, the proposed control strategy optimizes overall engine-aftertreatment-WHR system performance and deals with emission constraints. From simulations, the potential of this IPC strategy is demonstrated over a World Harmonized Transient Cycle (WHTC using a high-fidelity simulation model. These results are compared with a state-of-the-art baseline engine control strategy. By applying the IPC strategy, an additional 2.6% CO2 reduction is achieved compare to the baseline strategy, while meeting the tailpipe NOx emission limit. In addition, the proposed low-level WHR controller is shown to deal with the cold start challenges.

  1. Social Recovery Model: An 8-Year Investigation of Adolescent 12-step Group Involvement following Inpatient Treatment

    Science.gov (United States)

    Kelly, John F.; Brown, Sandra A.; Abrantes, Ana; Kahler, Christopher; Myers, Mark

    2013-01-01

    Background Despite widespread use of 12-step treatment approaches and referrals to Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) by youth providers, little is known about the significance of these organizations in youth addiction recovery. Furthermore, existing evidence is based mostly on short-term follow-up and is limited methodologically. Methods Adolescent inpatients (N = 160; M age = 16, 40% female) were followed at 6-months, and at 1, 2, 4, 6, and 8 years post-treatment. Time-lagged, generalized estimating equations (GEE) modeled treatment outcome in relation to AA/NA attendance controlling for static and time-varying covariates. Robust regression (LOWESS) explored dose-response thresholds of AA/NA attendance on outcome. Results AA/NA attendance was common and intensive early post-treatment, but declined sharply and steadily over the 8-year period. Patients with greater addiction severity and those who believed they could not use substances in moderation were more likely to attend. Despite declining attendance, the effects related to AA/NA remained significant and consistent. Greater early participation was associated with better long-term outcomes. Conclusions Even though many youth discontinue AA/NA over time, attendees appear to benefit, and more severely substance-involved youth attend most. Successful early post-treatment engagement of youth in abstinence-supportive social contexts, such as AA/NA, may have long-term implications for alcohol and drug involvement into young adulthood. PMID:18557829

  2. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model

    Directory of Open Access Journals (Sweden)

    Xiaowen Jiang

    2016-01-01

    Full Text Available This study investigated the effect of frankincense extract on peripheral nerve regeneration in a crush injury rat model. Forty-eight Sprague-Dawley rats were randomly divided into four groups: control and frankincense extract low-, medium-, and high-dose groups. At days 7, 14, 21, and 28 following the surgery, nerve regeneration and functional recovery were evaluated using the sciatic functional index (SFI, expression of GAP-43, and the proliferation of Schwann cells (SCs in vivo and in vitro. At day 7, the SFI in the frankincense extract high-dose group was significantly improved compared with the control group. After day 14, SFI was significantly improved in the medium- and high-dose groups. There was no significant difference in GAP-43 expression among the groups at day 7. However, after day 14, expression of GAP-43 in the high-dose group was higher than that in the control group. Histological evaluation showed that the injured nerve of frankincense extract high-dose group recovered better than the other groups 28 days after surgery. Further, S100 immunohistochemical staining, MTT colorimetry, and flow cytometry assays all showed that frankincense extract could promote the proliferation of SCs. In conclusion, frankincense extract is able to promote sciatic nerve regeneration and improve the function of a crushed sciatic nerve. This study provides a new direction for the repair of peripheral nerve injury.

  3. Spectrum recovery method based on sparse representation for segmented multi-Gaussian model

    Science.gov (United States)

    Teng, Yidan; Zhang, Ye; Ti, Chunli; Su, Nan

    2016-09-01

    Hyperspectral images can realize crackajack features discriminability for supplying diagnostic characteristics with high spectral resolution. However, various degradations may generate negative influence on the spectral information, including water absorption, bands-continuous noise. On the other hand, the huge data volume and strong redundancy among spectrums produced intense demand on compressing HSIs in spectral dimension, which also leads to the loss of spectral information. The reconstruction of spectral diagnostic characteristics has irreplaceable significance for the subsequent application of HSIs. This paper introduces a spectrum restoration method for HSIs making use of segmented multi-Gaussian model (SMGM) and sparse representation. A SMGM is established to indicating the unsymmetrical spectral absorption and reflection characteristics, meanwhile, its rationality and sparse property are discussed. With the application of compressed sensing (CS) theory, we implement sparse representation to the SMGM. Then, the degraded and compressed HSIs can be reconstructed utilizing the uninjured or key bands. Finally, we take low rank matrix recovery (LRMR) algorithm for post processing to restore the spatial details. The proposed method was tested on the spectral data captured on the ground with artificial water absorption condition and an AVIRIS-HSI data set. The experimental results in terms of qualitative and quantitative assessments demonstrate that the effectiveness on recovering the spectral information from both degradations and loss compression. The spectral diagnostic characteristics and the spatial geometry feature are well preserved.

  4. Concentration-driven models revisited: towards a unified framework to model settling tanks in water resource recovery facilities.

    Science.gov (United States)

    Torfs, Elena; Martí, M Carmen; Locatelli, Florent; Balemans, Sophie; Bürger, Raimund; Diehl, Stefan; Laurent, Julien; Vanrolleghem, Peter A; François, Pierre; Nopens, Ingmar

    2017-02-01

    A new perspective on the modelling of settling behaviour in water resource recovery facilities is introduced. The ultimate goal is to describe in a unified way the processes taking place both in primary settling tanks (PSTs) and secondary settling tanks (SSTs) for a more detailed operation and control. First, experimental evidence is provided, pointing out distributed particle properties (such as size, shape, density, porosity, and flocculation state) as an important common source of distributed settling behaviour in different settling unit processes and throughout different settling regimes (discrete, hindered and compression settling). Subsequently, a unified model framework that considers several particle classes is proposed in order to describe distributions in settling behaviour as well as the effect of variations in particle properties on the settling process. The result is a set of partial differential equations (PDEs) that are valid from dilute concentrations, where they correspond to discrete settling, to concentrated suspensions, where they correspond to compression settling. Consequently, these PDEs model both PSTs and SSTs.

  5. Effects of ray profile modeling on resolution recovery in clinical CT

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Christian [Institute of Medical Physics, Friedrich–Alexander University (FAU), Erlangen, Bavaria 91052 (Germany); Knaup, Michael [Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg 69120 (Germany); Kachelrieß, Marc, E-mail: marc.kachelriess@dkfz-heidelberg.de [Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany and Institute of Medical Physics, Friedrich–Alexander University (FAU), Erlangen, Bavaria 91052 (Germany)

    2014-02-15

    Purpose: Iterative image reconstruction gains more and more interest in clinical routine, as it promises to reduce image noise (and thereby patient dose), to reduce artifacts, or to improve spatial resolution. However, among vendors and researchers, there is no consensus of how to best achieve these goals. The authors are focusing on the aspect of geometric ray profile modeling, which is realized by some algorithms, while others model the ray as a straight line. The authors incorporate ray-modeling (RM) in nonregularized iterative reconstruction. That means, instead of using one simple single needle beam to represent the x-ray, the authors evaluate the double integral of attenuation path length over the finite source distribution and the finite detector element size in the numerical forward projection. Our investigations aim at analyzing the resolution recovery (RR) effects of RM. Resolution recovery means that frequencies can be recovered beyond the resolution limit of the imaging system. In order to evaluate, whether clinical CT images can benefit from modeling the geometrical properties of each x-ray, the authors performed a 2D simulation study of a clinical CT fan-beam geometry that includes the precise modeling of these geometrical properties. Methods: All simulations and reconstructions are performed in native fan-beam geometry. A water phantom with resolution bar patterns and a Forbild thorax phantom with circular resolution patterns representing calcifications in the heart region are simulated. An FBP reconstruction with a Ram–Lak kernel is used as a reference reconstruction. The FBP is compared to iterative reconstruction techniques with and without RM: An ordered subsets convex (OSC) algorithm without any RM (OSC), an OSC where the forward projection is modeled concerning the finite focal spot and detector size (OSC-RM) and an OSC with RM and with a matched forward and backprojection pair (OSC-T-RM, T for transpose). In all cases, noise was matched to

  6. Modeling economic costs of disasters and recovery involving positive effects of reconstruction: analysis using a dynamic CGE model

    Directory of Open Access Journals (Sweden)

    W. Xie

    2013-11-01

    Full Text Available Disaster damages have negative effects on economy, whereas reconstruction investments have positive effects. The aim of this study is to model economic causes of disasters and recovery involving positive effects of reconstruction activities. Computable general equilibrium (CGE model is a promising approach because it can incorporate these two kinds of shocks into a unified framework and further avoid double-counting problem. In order to factor both shocks in CGE model, direct loss is set as the amount of capital stock reduced on supply side of economy; A portion of investments restore the capital stock in existing period; An investment-driven dynamic model is formulated due to available reconstruction data, and the rest of a given country's saving is set as an endogenous variable. The 2008 Wenchuan Earthquake is selected as a case study to illustrate the model, and three scenarios are constructed: S0 (no disaster occurs, S1 (disaster occurs with reconstruction investment and S2 (disaster occurs without reconstruction investment. S0 is taken as business as usual, and the differences between S1 and S0 and that between S2 and S0 can be interpreted as economic losses including reconstruction and excluding reconstruction respectively. The study showed that output from S1 is found to be closer to real data than that from S2. S2 overestimates economic loss by roughly two times that under S1. The gap in economic aggregate between S1 and S0 is reduced to 3% in 2011, a level that should take another four years to achieve under S2.

  7. Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat.

    Science.gov (United States)

    Ishida, Akimasa; Misumi, Sachiyo; Ueda, Yoshitomo; Shimizu, Yuko; Cha-Gyun, Jung; Tamakoshi, Keigo; Ishida, Kazuto; Hida, Hideki

    2015-05-01

    Constraint-induced movement therapy (CIMT) promotes functional recovery of impaired forelimbs after hemiplegic strokes, including intracerebral hemorrhage (ICH). We used a rat model of subcortical hemorrhage to compare the effects of delivering early or late CIMT after ICH. The rat model was made by injecting collagenase into the globus pallidus near the internal capsule, and then forcing rats to use the affected forelimb for 7 days starting either 1 day (early CIMT) or 17 days (late CIMT) after the lesion. Recovery of forelimb function in the skilled reaching test and the ladder stepping test was found after early-CIMT, while no significant recovery was shown after late CIMT or in the non-CIMT controls. Early CIMT was associated with greater numbers of ΔFosB-positive cells in the ipsi-lesional sensorimotor cortex layers II-III and V. Additionally, we found expression of the growth-related genes brain-derived neurotrophic factor (BDNF) and growth-related protein 43 (GAP-43), and abundant dendritic arborization of pyramidal neurons in the sensorimotor area. Similar results were not detected in the contra-lesional cortex. In contrast to early CIMT, late CIMT failed to induce any changes in plasticity. We conclude that CIMT induces molecular and morphological plasticity in the ipsi-lesional sensorimotor cortex and facilitates better functional recovery when initiated immediately after hemorrhage. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Perceived control predicting the recovery of individual-specific walking behaviours following stroke: testing psychological models and constructs.

    Science.gov (United States)

    Bonetti, D; Johnston, M

    2008-09-01

    Perceived control predicts activity limitations, but there are many control belief concepts and how these are defined and measured has implications for intervention design. This study examined whether individual-specific activity limitations and recovery were predicted by theoretically derived control conceptualizations, the Theory of Planned Behaviour and an integrated model (Theory of Planned Behaviour with the World Health Organization ICF (International Classification of Functioning, Disability and Health) model). This predictive cohort study used measures of impairment, intention and perceived control (perceived behavioural control, Theory of Planned Behaviour; self-efficacy, Social Cognitive Theory; locus of control, Social Learning Theory), assessed 2 weeks after hospital discharge, to predict walking limitation (UK SIP: FLP) and recovery after 6 months. Theoretically derived items were individually tailored for patients' baseline walking limitation. Two hundred and three stroke patients (124 men and 79 women; mean age = 68.88, SD = 12.31 years) Walking limitation and walking recovery (respectively) were predicted by perceived behavioural control (r = -.36(**), .26(**)) and self-efficacy (r = -.30(**), .22(**)), but not locus of control (r = -.07, .02). Both theoretical models accounted for significant variance in walking limitation and recovery--but not beyond that explained by perceived behavioural control. Predictive power was not improved by modifying the control component or by including impairment in regression equations. Results suggest that perceived control predicts individual-specific disability and recovery and that reductions in activity limitations may be achieved by manipulating control cognitions. In addition, reducing impairments may not have maximal effect on reducing disability unless beliefs about control over performing the behaviour are also influenced.

  9. Modelling, sizing and testing a scroll expander for a waste heat recovery application on a gasoline engine

    Science.gov (United States)

    Legros, Arnaud; Guillaume, Ludovic; Diny, Mouad; Lemort, Vincent

    2015-08-01

    Waste heat recovery technologies in a mobile application emerge every time energy becomes a valuable resource. It has been the case in the 70s with oil crisis and it is starting to regain some interests now due to the continuously rising price of oil and due to the restrictive standards imposed by the different governments. This paper deals with the recovery on the exhaust gases of an internal combustion engine by using a Rankine system. The study focuses on the expander, which is one of the most important components of the system. The use of a scroll expander operating with steam is currently investigated through simulation and experimentation. This paper presents the modelling of a scroll expander. The model is a detailed model including various losses such as leakage, friction or under or over expansion. This model has been used to design and size a tailor-made scroll expander. This was necessary due to the small amount of expanders on the market and also to have a machine that fits our application. After designing the machine, a prototype has been built. It has also been tested on our prototype bench of waste heat recovery on a gasoline engine, by means of a Rankine cycle. Measured performance will be presented, analysed and compared to predictions by the model. The first results will be presented here and discussed in order to give recommendations for the design of next prototypes.

  10. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL for Clock Data Recovery (CDR

    Directory of Open Access Journals (Sweden)

    Zainab Mohamad Ashari

    2012-01-01

    Full Text Available Modern communication and computer systems require rapid (Gbps, efficient  and large bandwidth data transfers. Agressive scaling of digital integrated systems  allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The  Peripheral Component Interconnect Express (PCIe protocol handles all communcation between the central processing unit (CPU and hardware devices. PCIe buses require efficient clock data recovery circuits (CDR to recover clock signals embedded in data during transmission. This paper describes the theoretical modeling and simulation of a phase-locked loop (PLL used in a CDR circuit. A simple PLL architecture for a 5 GHz CDR circuit is proposed  and elaborated in this work. Simulations were carried out using a Hardware Description Language, Verilog-AMS. The effect of jitter on the proposed design is also simulated and evaluated in this work. It was found that the proposed design is robust against both input and VCO jitter.ABSTRAK: Sistem komunikasi dan komputer moden memerlukan pemindahan data yang cekap (Gbps, dan bandwidth yang besar. Pengecilan agresif menggunakan teknik sistem digital bersepadu membenarkan bas dan litar pengawal komunikasi disatukan dengan  mikroprocessor dalam cip yang sama. Protokol persisian komponen sambung tara ekspres (PCIe mengendalikan semua komunikasi antara unit pemprosesan pusat (CPU dan peranti perkakasan. Bas PCIe memerlukan litar jam pemulihan data (CDR yang cekap untuk mendapatkan kembali isyarat jam yang tertanam dalam data semasa transmisi. Karya ini menerangkan teori pemodelan dan simulasi gelung fasa terkunci (PLL untuk CDR. Rekabentuk 5 GHz PLL yang mudah telah dicadangkan dalm kertas kerja ini. Simulasi telah dijalankan menggunakan perisian verilog-AMS. Simulasi mengunnakan kesan ketar dalam reka bentuk yang dicadangkan telah dinilai. Reka bentuk yang dicadangkan terbukti teguh mengatasi ganguan ketar di input dan VCO.KEY WORDS

  11. Advances in computational modeling of catalytic systems used in Claus sulfur recovery

    Energy Technology Data Exchange (ETDEWEB)

    Clark, P.D.; Lo, J. [Alberta Sulphur Research Ltd., Calgary, AB (Canada). Center for Applied Catalysis and Industrial Sulfur Chemistry

    2010-01-15

    This poster session discussed advances in computation modeling of catalytic systems used in Claus sulfur recovery, focusing on the hydrogen sulphide (H{sub 2}S) and sulphur dioxide (S{sub O}2) absorption of non-alumina Claus active metal oxides, such as titanium oxide and vanadium oxide. These metal oxides were chosen because they promote carbon disulphide (CS{sub 2}) conversion and have a potential use in olefin chemistry. The redox process of H{sub 2}S dissociation on vanadium pentoxide (V{sub 2}O{sub 2}) can take place in single-site reaction or multiple site reactions. Both mechanisms lead to the production of V{sub 2}O{sub 4}S, water (H{sub 2}O) and other species. The overall process of forming VO{sub 4}S is neutral, but kinetics is a controlling factor. The surface sulfidation to form V{sub 2}O{sub 3}S{sub 2} requires a small energy cost but possesses a huge reaction barrier. The formation of H{sub 2}S{sub 2} is energetically favorable. The silica (SiO{sub 2})-supported V{sub 2}O{sub 2} catalyst was described. A proposed mechanism of H{sub 2}S conversion to H{sub 2}O and V=S group was presented along with another reaction route in which the dissociative absorption of H{sub 2}S takes place on O-bridges instead of V=O. Two vanadia catalysts were compared: V{sub 2}O{sub 5} and V{sub 2}O{sub 5}/SiO{sub 2}. 7 figs.

  12. Black liquor combustion validated recovery boiler modeling: Final year report. Volume 2 (Appendices I, section 5 and II, section 1)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1998-08-01

    This project was initiated in October 1990, with the objective of developing and validating a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The key tasks to be accomplished were as follows: (1) Complete the development of enhanced furnace models that have the capability to accurately predict carryover, emissions behavior, dust concentrations, gas temperatures, and wall heat fluxes. (2) Validate the enhanced furnace models, so that users can have confidence in the predicted results. (3) Obtain fundamental information on aerosol formation, deposition, and hardening so as to develop the knowledge base needed to relate furnace model outputs to plugging and fouling in the convective sections of the boiler. (4) Facilitate the transfer of codes, black liquid submodels, and fundamental knowledge to the US kraft pulp industry. Volume 2 contains the last section of Appendix I, Radiative heat transfer in kraft recovery boilers, and the first section of Appendix II, The effect of temperature and residence time on the distribution of carbon, sulfur, and nitrogen between gaseous and condensed phase products from low temperature pyrolysis of kraft black liquor.

  13. Recovery model of temporary threshold shifts from exposures with the same L_Aeq,T and different frequency components

    DEFF Research Database (Denmark)

    Ordonez, Rodrigo; Hammershøi, Dorte

    2005-01-01

    Temporary Threshold Shifts (TTS) were determined for 9 subjects exposed to three different band-passed signals taken from one channel of a binaural recording of an industrial mill. The three 2-octave bands were: Low (125 to 500 Hz), mid (500 Hz to 2 kHz), and high (2 kHz to 8 kHz). The band-passe...... signals may not be well characterised by the A-weighting curve. The present paper presents the recovery model and discusses the application of the model to the present TTS data.......-passed signals were adjusted to give the same equivalent A-weighted sound exposure according to ISO-1999 (1990) and were presented to one ear of the subjects in three separate experimental sessions. The results were used in a recovery model based on a least-squares fit of the data to a superposition...... of exponential functions. The recovery model showed good agreement with the average TTS across subjects and confirms that the high band caused the greatest TTS. The difference between the TTS caused by exposures with the same A-weighted equivalent level, suggests that the frequency characteristics of exposure...

  14. Experimental and analytical modeling of gravity drainage dominated heavy-oil recovery under non-isothermal conditions: a microscale approach

    Energy Technology Data Exchange (ETDEWEB)

    Arguelles-Vivas, F.J.; Babadagli, T. [University of Alberta (Canada)

    2011-07-01

    One of the good examples of a non-isothermal, gravity dominated recovery application is the steam assisted gravity drainage (SAGD) process. It is usually observed that this process yields lower recovery than expected in field applications. To avoid this problem, a detailed understanding of the problem at the pore scale is necessary to account for the residual oil saturation in the swept zone. Uncertainty still exists as to the extent of the impact of pore scale mechanisms on the process of non-isothermal gravity drainage dominated heavy oil recovery. This paper presents experimental and analytical modeling of gravity drainage dominated heavy oil recovery. A single capillary tube is used to mimic an elementary volume in the swept area. Two and three-phase flow displacements were carried out in a capillary tube under isothermal and non-isothermal conditions. The analytical calculations suggest that, at low capillary numbers, temperature does not have a significant impact on the residual saturation of processed or crude oil.

  15. Accelerating recovery from jet lag: prediction from a multi-oscillator model and its experimental confirmation in model animals

    Science.gov (United States)

    Kori, Hiroshi; Yamaguchi, Yoshiaki; Okamura, Hitoshi

    2017-04-01

    The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one’s internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such misalignments are accompanied by sleep disturbances and gastrointestinal distress. Repeated exposure to jet lag and rotating shift work increases the risk of lifestyle-related diseases, such as cardiovascular complaints and metabolic insufficiencies. However, the mechanism behind the disruption of one’s internal clock is not well understood. In this paper, we therefore present a new theoretical concept called “jet lag separatrix” to understand circadian clock disruption and slow recovery from jet lag based on the mathematical model describing the hierarchical structure of the circadian clock. To demonstrate the utility of our theoretical study, we applied it to predict that re-entrainment via a two-step jet lag in which a four-hour shift of the light-dark cycle is given in the span of two successive days requires fewer days than when given as a single eight-hour shift. We experimentally verified the feasibility of our theory in C57BL/6 strain mice, with results indicating that this pre-exposure of jet lag is indeed beneficial.

  16. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    Energy Technology Data Exchange (ETDEWEB)

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  17. Modeling Reservoir Formation Damage due to Water Injection for Oil Recovery

    DEFF Research Database (Denmark)

    Yuan, Hao

    2010-01-01

    The elliptic equation for non-Fickian transport of suspension in porous media is applied to simulate the reservoir formation damage due to water injection for oil recovery. The deposition release (erosion of reservoir formation) and the suspension deposition (pore plugging) are both taken...

  18. Sizing models and performance analysis of waste heat recovery organic Rankine cycles for heavy duty trucks

    OpenAIRE

    Guillaume, Ludovic; Legros, Arnaud; Quoilin, Sylvain; Declaye, Sébastien; Lemort, Vincent

    2013-01-01

    This paper attempts to address this problematic of selecting the architecture, the expander and the working fluid for a waste heat recovery organic (or non-organic) Rankine cycle on a truck engine. It focuses especially on three expander technologies: the scroll, the piston and the screw expanders, and three working fluids: R245fa, ethanol and water. Peer reviewed

  19. Modeling of in-situ combustion as thermal recovery method for heavy (medium) oil (poster)

    NARCIS (Netherlands)

    Khoshnevis Gargar, N.; Achterbergh, N.; Rudolph, E.S.J.; Bruining, J.

    2010-01-01

    In-situ combustion (ISC), as a well known process for secondary and tertiary oil recovery, is an important alternative approach to achieve higher production efficiency for light and heavy oil reservoirs. The in-situ combustion process is a complex combination of a number of processes which occur in

  20. Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis.

    Science.gov (United States)

    Tang, Yueming; Preuss, Fabian; Turek, Fred W; Jakate, Shriram; Keshavarzian, Ali

    2009-06-01

    We recently showed that patients with inflammatory bowel disease (IBD) report significantly more sleep disturbances. To determine whether disrupted sleep can affect the severity of inflammation and the course of IBD, we used an animal model of colonic inflammation to determine the effects of acute and chronic intermittent sleep deprivation on the severity of colonic inflammation and tissue damage in colitis and recovery from this damage. Acute sleep deprivation (ASD) consisted of 24h of forced locomotor activity in a mechanical wheel rotating at a constant speed. Chronic intermittent sleep deprivation (CISD) consisted of an acute sleep deprivation episode, followed by additional sleep deprivation periods in the wheel for 6h every other day throughout the 10day study period. To induce colitis, mice were given 2% dextran sodium sulfate (DSS) in their daily drinking water for 7days. The development and severity of colitis were monitored by measuring weight loss and tissue myeloperoxidase (MPO) activity daily and colon histology scores 10days after initiation of colitis. ASD or CISD did not cause colonic inflammation in vehicle-treated mice. Changes in daily body weight, tissue MPO levels and colon histopathology score were similar between mice that were sleep deprived and controls. Daily DSS ingestion caused colitis in mice. ASD worsened colonic inflammation: tissue MPO levels in ASD/DSS-treated mice were significantly higher than in DSS-treated mice that were not sleep deprived. However, the worsening of colonic inflammation by ASD was not enough to exacerbate clinical manifestations of colitis such as weight loss. In contrast, the deleterious effects of CISD were severe enough to cause worsening of histological and clinical manifestations of colitis. The deleterious effects of sleep deprivation on severity of colitis appeared to be due to both increased colonic inflammation and a decrease in the ability of mice to recover from DSS-induced colonic injury. Both acute

  1. Process-based reactive transport model to quantify arsenic mobility during aquifer storage and recovery of potable water.

    Science.gov (United States)

    Wallis, Ilka; Prommer, Henning; Pichler, Thomas; Post, Vincent; Norton, Stuart B; Annable, Michael D; Simmons, Craig T

    2011-08-15

    Aquifer storage and recovery (ASR) is an aquifer recharge technique in which water is injected in an aquifer during periods of surplus and withdrawn from the same well during periods of deficit. It is a critical component of the long-term water supply plan in various regions, including Florida, USA. Here, the viability of ASR as a safe and cost-effective water resource is currently being tested at a number of sites due to elevated arsenic concentrations detected during groundwater recovery. In this study, we developed a process-based reactive transport model of the coupled physical and geochemical mechanisms controlling the fate of arsenic during ASR. We analyzed multicycle hydrochemical data from a well-documented affected southwest Floridan site and evaluated a conceptual/numerical model in which (i) arsenic is initially released during pyrite oxidation triggered by the injection of oxygenated water (ii) then largely complexes to neo-formed hydrous ferric oxides before (iii) being remobilized during recovery as a result of both dissolution of hydrous ferric oxides and displacement from sorption sites by competing anions.

  2. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury.

    Science.gov (United States)

    Wang, Zefeng; Song, Fahuan; Li, Jinhui; Zhang, Yuyan; He, Yu; Yang, Jiehong; Zhou, Huifen; Zhao, Tao; Fu, Wei; Xing, Panke; Wan, Haitong; Tian, Mei; Zhang, Hong

    2014-01-01

    This study aimed to investigate neuroprotection of Danhong injection (DHI) in a rat model of cerebral ischemia using (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET). Method. Rats were divided into 5 groups: sham group, ischemia-reperfusion untreated (IRU) group, DHI-1 group (DHI 1 mL/kg/d), DHI-2 group (DHI 2 mL/kg/d), and DHI-4 group (DHI 4 mL/kg/d). AII the treated groups were intraperitoneally injected with DHI daily for 14 days. The therapeutic effects in terms of cerebral infarct volume, neurological function, and cerebral glucose metabolism were evaluated. Expression of TNF-α and IL-1β was detected with enzyme-linked immunosorbent assay (ELISA). Levels of mature neuronal marker (NeuN), glial marker (GFAP), vascular density factor (vWF), and glucose transporter 1 (GLUT1) were assessed by immunohistochemistry. Results. Compared with the IRU group, rats treated with DHI showed dose dependent reductions in cerebral infarct volume and levels of proinflammatory cytokines, improvement of neurological function, and recovery of cerebral glucose metabolism. Meanwhile, the significantly increased numbers of neurons, gliocytes, and vessels and the recovery of glucose utilization were found in the peri-infarct region after DHI treatment using immunohistochemical analysis. Conclusion. This study demonstrated the metabolic recovery after DHI treatment by micro-PET imaging with (18)F-FDG and the neuroprotective effects of DHI in a rat model of cerebral ischemic-reperfusion injury.

  3. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury

    Directory of Open Access Journals (Sweden)

    Zefeng Wang

    2014-01-01

    Full Text Available This study aimed to investigate neuroprotection of Danhong injection (DHI in a rat model of cerebral ischemia using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET. Method. Rats were divided into 5 groups: sham group, ischemia-reperfusion untreated (IRU group, DHI-1 group (DHI 1 mL/kg/d, DHI-2 group (DHI 2 mL/kg/d, and DHI-4 group (DHI 4 mL/kg/d. AII the treated groups were intraperitoneally injected with DHI daily for 14 days. The therapeutic effects in terms of cerebral infarct volume, neurological function, and cerebral glucose metabolism were evaluated. Expression of TNF-α and IL-1β was detected with enzyme-linked immunosorbent assay (ELISA. Levels of mature neuronal marker (NeuN, glial marker (GFAP, vascular density factor (vWF, and glucose transporter 1 (GLUT1 were assessed by immunohistochemistry. Results. Compared with the IRU group, rats treated with DHI showed dose dependent reductions in cerebral infarct volume and levels of proinflammatory cytokines, improvement of neurological function, and recovery of cerebral glucose metabolism. Meanwhile, the significantly increased numbers of neurons, gliocytes, and vessels and the recovery of glucose utilization were found in the peri-infarct region after DHI treatment using immunohistochemical analysis. Conclusion. This study demonstrated the metabolic recovery after DHI treatment by micro-PET imaging with 18F-FDG and the neuroprotective effects of DHI in a rat model of cerebral ischemic-reperfusion injury.

  4. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model.

    Directory of Open Access Journals (Sweden)

    Hong J Lee

    Full Text Available BACKGROUND: Intracerebral hemorrhage (ICH is a lethal stroke type. As mortality approaches 50%, and current medical therapy against ICH shows only limited effectiveness, an alternative approach is required, such as stem cell-based cell therapy. Previously we have shown that intravenously transplanted human neural stem cells (NSCs selectively migrate to the brain and induce behavioral recovery in rat ICH model, and that combined administration of NSCs and vascular endothelial growth factor (VEGF results in improved structural and functional outcome from cerebral ischemia. METHODS AND FINDINGS: We postulated that human NSCs overexpressing VEGF transplanted into cerebral cortex overlying ICH lesion could provide improved survival of grafted NSCs, increased angiogenesis and behavioral recovery in mouse ICH model. ICH was induced in adult mice by unilateral injection of bacterial collagenase into striatum. HB1.F3.VEGF human NSC line produced an amount of VEGF four times higher than parental F3 cell line in vitro, and induced behavioral improvement and 2-3 fold increase in cell survival at two weeks and eight weeks post-transplantation. CONCLUSIONS: Brain transplantation of F3 human NSCs over-expressing VEGF near ICH lesion sites provided differentiation and survival of grafted human NSCs and renewed angiogenesis of host brain and functional recovery of ICH animals. These results suggest a possible application of the human neural stem cell line, which is genetically modified to over-express VEGF, as a therapeutic agent for ICH-stroke.

  5. The recovery of the otter in the Cevennes (France: a GIS-based model

    Directory of Open Access Journals (Sweden)

    Xaver Janssens

    2006-09-01

    Full Text Available Abstract
    The Eurasian otter (Lutra lutra is an elusive semi-aquatic mammal. Its absence is difficult to prove and censuses can be biased by false-negative observations. A model is proposed to correct this bias by predicting occurrence probabilities where observations are negative. In case of otter signs observation in one place, the probability to find the species in another place is assumed to decrease if the distance between both places increases. This approach is tested on a 15-years otter survey dataset (4592 data from the National Cevennes Park (3200 km2, France. Four methods are compared, using Euclidian distances, decisional distances, cost-weighted distances and basin analyses. The validation is performed on 61 stretches that were prospected each year in the Cevennes. For these stretches, if observations were negative during a year A but positive during the previous and the following year, observations were assumed to be false-negative during this year A and compared to predictions given each modelling method. The modelling proves the interest of describing the landscape and defining spatially weighted distances from places where otter is present to predict the species occurrence where its search is unsuccessful. The results highlight that, despite the high mobility of the otter, its distribution is limited by some watershed limits. Hydrographical basins represent a relevant spatial unit to predict the otter occurrence and to analyse its recovery.
    Riassunto
    L’espansione della Lontra nelle Cevennes (Francia: un modello predittivo basato sul GIS. La Lontra ( Lutra lutra è un mammifero semi-acquatico dal comportamento elusivo e il mancato ritrovamento di segni di presenza non implica necessariamente l’assenza del mustelide dall’area in esame. Viene proposto un modello per stimare la probabilità di presenza della specie quando le osservazioni diano esito negativo, assumendo che, dati dei

  6. Effects of balance and gait training on the recovery of the motor function in an animal model of Parkinson's disease.

    Science.gov (United States)

    Yoon, Young-Jeoi; Lee, Byung-Hoon

    2014-06-01

    [Purpose] This study was conducted to investigate the effect of balance and gait training on the recovery of the motor function in a Parkinson's disease animal models. [Subjects and Methods] A total of 40 mice were randomly classified into four groups with 10 in each group: Group I-Normal; Group II-Parkinson's disease and no training; Group III-Parkinson's disease and balance training was performed; and Group IV-Parkinson's disease and gait training. Parkinson's disease was induced by administration of MPTP to animals in Groups II-IV. Groups III and IV did training once a day, five days a week, for four weeks. Neurobehavioral evaluation was performed through the pole and open-field tests. Immunological evaluation was performed via TH (tyrosine hydroxylase) protein expression, using western blot analysis. [Results] In the result of the pole test, Groups III and IV showed significantly greater motor function recovery than to Group II. The results of the open-field test also showed that Groups III and IV had significantly greater motor function recovery than to Group II, and Group IV showed significantly greater motor function recovery than to Group III. Using western blot analysis, we determined that the expression of TH protein in the corpus striatum was greatest in group I, followed by Groups III and IV, and that Group II had the lowest TH protein expression in the corpus striatum. [Conclusion] The results of this study showed that balance and gait training were effective at recovering the motor functions of a Parkinson's disease animal models induced by MPTP, and that gait training was more effective than balance training.

  7. Fluoxetine treatment promotes functional recovery in a rat model of cervical spinal cord injury

    Science.gov (United States)

    Scali, Manuela; Begenisic, Tatjana; Mainardi, Marco; Milanese, Marco; Bonifacino, Tiziana; Bonanno, Giambattista; Sale, Alessandro; Maffei, Lamberto

    2013-01-01

    Spinal cord injury (SCI) is a severe condition leading to enduring motor deficits. When lesions are incomplete, promoting spinal cord plasticity might be a useful strategy to elicit functional recovery. Here we investigated whether long-term fluoxetine administration in the drinking water, a treatment recently demonstrated to optimize brain plasticity in several pathological conditions, promotes motor recovery in rats that received a C4 dorsal funiculus crush. We show that fluoxetine administration markedly improved motor functions compared to controls in several behavioral paradigms. The improved functional effects correlated positively with significant sprouting of intact corticospinal fibers and a modulation of the excitation/inhibition balance. Our results suggest a potential application of fluoxetine treatment as a non invasive therapeutic strategy for SCI-associated neuropathologies. PMID:23860568

  8. Theoretical Modeling and Simulation of Phase-Locked Loop (PLL) for Clock Data Recovery (CDR)

    OpenAIRE

    Zainab Mohamad Ashari; Anis Nurashikin Nordin

    2012-01-01

    Modern communication and computer systems require rapid (Gbps), efficient  and large bandwidth data transfers. Agressive scaling of digital integrated systems  allow buses and communication controller circuits to be integrated with the microprocessor on the same chip. The  Peripheral Component Interconnect Express (PCIe) protocol handles all communcation between the central processing unit (CPU) and hardware devices. PCIe buses require efficient clock data recovery circuits (CD...

  9. Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity

    Directory of Open Access Journals (Sweden)

    Yang Runkuan

    2011-11-01

    Full Text Available Abstract Background Acetaminophen (APAP overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0, the regeneration process requires the priming of hepatocytes by cytokines such as TNF-α and IL-6. Ringer's lactate solution (RLS has been shown to increase serum TNF-α and IL-6 in patients and experimental animals; in addition, RLS also provides lactate, which can be used as an alternative metabolic fuel to meet the higher energy demand by liver regeneration. Therefore, we tested whether RLS therapy improves liver recovery after APAP overdose. Methods C57BL/6 male mice were intraperitoneally injected with a single dose of APAP (300 mg/kg dissolved in 1 mL sterile saline. Following 2 hrs of APAP challenge, the mice were given 1 mL RLS or Saline treatment every 12 hours for a total of 72 hours. Results 72 hrs after APAP challenge, compared to saline-treated group, RLS treatment significantly lowered serum transaminases (ALT/AST and improved liver recovery seen in histopathology. This beneficial effect was associated with increased hepatic tissue TNF-α concentration, enhanced hepatic NF-κB DNA binding and increased expression of cell cycle protein cyclin D1, three important factors in liver regeneration. Conclusion RLS improves liver recovery from APAP hepatotoxicity.

  10. A simple model of growth form-dependent recovery from disease in coral reef sponges, and implications for monitoring

    Science.gov (United States)

    Wulff, Janie L.

    2006-08-01

    For clonal organisms that can suffer high levels of partial mortality and still recover, the conditions that influence infection and development of disease (e.g., abiotic stressors, population density) may be very different from the conditions that influence recovery. Recovery from infectious disease may increase if an individual can mount a defense before infection spreads throughout its body. If pathogens spread within an organism from an initial infection point, growth form—in conjunction with size—can influence the amount of time before all the tissue is diseased, and recovery precluded. A simple model of pathogen progression within individual sponges predicts that species with massive growth forms will be most susceptible to being overwhelmed by pathogen infection, and branching species will be most likely to recover. These predictions may help to explain the seemingly contradictory observations that branching species had the greatest prevalence of disease, and massive species the greatest rate of loss, in a monitored coral reef community. Disease may be observed disproportionately frequently in the organisms that are most likely to recover, resulting in underestimation, by standard monitoring procedures, of the effect of disease on losses from the community.

  11. Hierarchical linear modeling of visual acuity change over time: rate of functional recovery after macular hole surgery.

    Science.gov (United States)

    Wittich, Walter; Overbury, Olga; Kapusta, Michael A; Watanabe, Donald H

    2007-09-01

    To examine acuity recovery rate after Macular Hole (MH) surgery, using Hierarchical Linear Modeling (HLM) with linear and curvilinear regression analysis. Preoperative MH diameter (OCT) and acuity (ETDRS) were recorded in 20 eyes. Acuities were tested during follow-up (6 to 23 months), with three to eight measurements per eye. The resulting 95 acuities were analyzed using HLM. Variability at the level of the person was explained by change over time, using a natural logarithm conversion. Across patients, MH diameter was used to predict slopes and intercepts at the level of the individual. MH diameter was able to account for significant amounts of variability in preoperative acuity (intercept) and significantly influenced rate of functional recovery (slope). A nonlinear approach to the data accounted for the largest amount of variance. Participants with larger MHs recovered relatively more acuity sooner while eyes with smaller MHs had better absolute acuity outcome. HLM provides important insight into the recovery process after MH surgery and is more flexible with follow-up data. In the context of MH treatment, most recuperation occurred during the initial 6 months.

  12. A comprehensive model of gain recovery due to unipolar electron transport after a short optical pulse in quantum cascade lasers

    Science.gov (United States)

    Jamali Mahabadi, S. E.; Hu, Yue; Talukder, Muhammad Anisuzzaman; Carruthers, Thomas F.; Menyuk, Curtis R.

    2016-10-01

    We have developed a comprehensive model of gain recovery due to unipolar electron transport after a short optical pulse in quantum cascade lasers (QCLs) that takes into account all the participating energy levels, including the continuum, in a device. This work takes into account the incoherent scattering of electrons from one energy level to another and quantum coherent tunneling from an injector level to an active region level or vice versa. In contrast to the prior work that only considered transitions to and from a limited number of bound levels, this work include transitions between all bound levels and between the bound energy levels and the continuum. We simulated an experiment of S. Liu et al., in which 438-pJ femtosecond optical pulses at the device's lasing wavelength were injected into an I n0.653 Ga0.348 As/In0.310 Al0.690 As QCL structure; we found that approximately 1% of the electrons in the bound energy levels will be excited into the continuum by a pulse and that the probability that these electrons will be scattered back into bound energy levels is negligible, ˜10-4 . The gain recovery that is predicted is not consistent with the experiments, indicating that one or more phenomena besides unipolar electron transport in response to a short optical pulse play an important role in the observed gain recovery.

  13. Environmental enrichment induces behavioral recovery and enhanced hippocampal cell proliferation in an antidepressant-resistant animal model for PTSD.

    Directory of Open Access Journals (Sweden)

    Hendrikus Hendriksen

    Full Text Available BACKGROUND: Post traumatic stress disorder (PTSD can be considered the result of a failure to recover after a traumatic experience. Here we studied possible protective and therapeutic aspects of environmental enrichment (with and without a running wheel in Sprague Dawley rats exposed to an inescapable foot shock procedure (IFS. METHODOLOGY/PRINCIPAL FINDINGS: IFS induced long-lasting contextual and non-contextual anxiety, modeling some aspects of PTSD. Even 10 weeks after IFS the rats showed reduced locomotion in an open field. The antidepressants imipramine and escitalopram did not improve anxiogenic behavior following IFS. Also the histone deacetylase (HDAC inhibitor sodium butyrate did not alleviate the IFS induced immobility. While environmental enrichment (EE starting two weeks before IFS did not protect the animals from the behavioral effects of the shocks, exposure to EE either immediately after the shock or one week later induced complete recovery three weeks after IFS. In the next set of experiments a running wheel was added to the EE to enable voluntary exercise (EE/VE. This also led to reduced anxiety. Importantly, this behavioral recovery was not due to a loss of memory for the traumatic experience. The behavioral recovery correlated with an increase in cell proliferation in hippocampus, a decrease in the tissue levels of noradrenalin and increased turnover of 5-HT in prefrontal cortex and hippocampus. CONCLUSIONS/SIGNIFICANCE: This animal study shows the importance of (physical exercise in the treatment of psychiatric diseases, including post-traumatic stress disorder and points out the possible role of EE in studying the mechanism of recovery from anxiety disorders.

  14. The Train Driver Recovery Problem - a Set Partitioning Based Model and Solution Method

    DEFF Research Database (Denmark)

    Rezanova, Natalia Jurjevna; Ryan, David

    The need to recover a train driver schedule occurs during major disruptions in the daily railway operations. Using data from the train driver schedule of the Danish passenger railway operator DSB S-tog A/S, a solution method to the Train Driver Recovery Problem (TDRP) is developed. The TDRP is fo...... the depth-first search of the Branch & Bound tree. Preliminarily results are encouraging, showing that nearly all tested real-life instances produce integer solutions to the LP relaxation and solutions are found within a few seconds....

  15. Modelling stressors on the eelgrass recovery process in two Danish estuaries

    DEFF Research Database (Denmark)

    Kuusemäe, Kadri; Rasmussen, Erik Kock; Canal-Vergés, Paula

    2016-01-01

    succeeded. The mechanisms hindering/delaying eelgrass recovery were recently identified: 1) lack of sediment anchoring capacity, 2) resuspension created by drifting ephemeral macroalgae, 3) seedling uprooting created by current and wave forces, 4) ballistic stress from attached macroalgae and 5) burial...... the second strongest negative impact on eelgrass growth, area reduction of 78.31% and 73.14% in Odense and Roskilde Fjord was seen. Ballistic stress from attached macroalgae also reduced growth drastically. Light conditions, sediment organic content along with shear stress at the sediment surface impact...

  16. Development and verification of simplified prediction models for enhanced oil recovery applications. CO/sub 2/ (miscible flood) predictive model. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Paul, G.W.

    1984-10-01

    A screening model for CO/sub 2/ miscible flooding has been developed consisting of a reservoir model for oil rate and recovery and an economic model. The reservoir model includes the effects of viscous fingering, reservoir heterogeneity, gravity segregation and areal sweep. The economic model includes methods to calculate various profitability indices, the windfall profits tax, and provides for CO/sub 2/ recycle. The model is applicable to secondary or tertiary floods, and to solvent slug or WAG processes. The model does not require detailed oil-CO/sub 2/ PVT data for execution, and is limited to five-spot patterns. A pattern schedule may be specified to allow economic calculations for an entire project to be made. Models of similar architecture have been developed for steam drive, in-situ combustion, surfactant-polymer flooding, polymer flooding and waterflooding. 36 references, 41 figures, 4 tables.

  17. Exploring the impact of plasticity-related recovery after brain damage in a connectionist model of single-word reading.

    Science.gov (United States)

    Welbourne, Stephen R; Ralph, Matthew A Lambon

    2005-03-01

    The effect of retraining a damaged connectionist model of single-word reading was investigated with the aim of establishing whether plasticity-related changes occurring during the recovery process can contribute to our understanding of the pattern of dissociations found in brain-damaged patients. In particular, we sought to reproduce the strong frequency x consistency interactions found in surface dyslexia. A replication of Plaut, McClelland, Seidenberg, and Patterson's (1996) model of word reading was damaged and then retrained, using a standard backpropagation algorithm. Immediately after damage, there was only a small frequency x consistency interaction. Retraining the damaged model crystallized out these small differences into a strong dissociation, very similar to the pattern found in surface dyslexic patients. What is more, the percentage of regularization errors, always high in surface dyslexics, increased greatly over the retraining period, moving from under 10% to over 80% in some simulations. These results suggest that the performance patterns of brain-damaged patients can owe as much to the substantial changes in the pattern of connectivity occurring during recovery as to the original premorbid structure. This finding is discussed in relation to the traditional cognitive neuropsychological assumptions of subtractivity and transparency.

  18. EFFECT OF MULTIPATH CHANNEL MODELS TO THE RECOVERY ALGORITHMS ON COMPRESSED SENSING IN UWB CHANNEL ESTIMATION

    Institute of Scientific and Technical Information of China (English)

    Nguyen ThanhSon; Guo Shuxu; Chen Haipeng

    2013-01-01

    Multipath arrivals in an Ultra-WideBand (UWB) channel have a long time intervals between clusters and rays where the signal takes on zero or negligible values.It is precisely the signal sparsity of the impulse response of the UWB channel that is exploited in this work aiming at UWB channel estimation based on Compressed Sensing (CS).However,these multipath arrivals mainly depend on the channel environments that generate different sparse levels (low-sparse or high-sparse) of the UWB channels.According to this basis,we have analyzed the two most basic recovery algorithms,one based on linear programming Basis Pursuit (BP),another using greedy method Orthogonal Matching Pursuit (OMP),and chosen the best recovery algorithm which are suitable to the sparse level for each type of channel environment.Besides,the results of this work is an open topic for further research aimed at creating a optimal algorithm specially for application of CS based UWB systems.

  19. Modelling of degradation/recovery phenomena in CdS/CdTe ultrathin film solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Gorji, Nima E. [University of Bologna, Department of Electrical, Electronic, and Information Engineering, Bologna (Italy)

    2015-04-01

    The degradation/recovery phenomena in ultrathin film solar cells based on CdS/CdTe are theoretically analysed using Sah-Noyce-Shockley theory for generation and recombination in the depletion region. This theory can explain the overlap of the depletion regions at both front and back contacts where the carrier generation and collection are as important as recombination mechanism. The value of physical parameters such as uncompensated defect density, carrier recombination lifetime and band bending at interface are critically important when reducing the thickness of CdTe layer down to sub-micron. The rollover, materials inter-/out-diffusion, complex defect formation and the role of mobile ions are taken into consideration to obtain an insight into the physics of degradation/recovery phenomena in ultrathin CdTe film solar cells. Both mechanisms are precisely analysed drawing the schematics of the energy band diagrams and mobile ions transport paths which in this case is the grain interior. This means that we neglect the metal diffusion through the grain boundaries which are assumed to be completely passivated. This assumption enabled us to study the role of the defects on the carrier transport in the interiors rather than through the boundaries. (orig.)

  20. Eclectic/mixed model method for upper extremity functional recovery in stroke rehabilitation: A pilot study.

    Science.gov (United States)

    Kumar, K Vijaya; Joshua, Abraham M; Kedambadi, Rakshith; Mithra, P Prasanna

    2017-01-01

    Eclectic treatment method is a flexible approach that uses techniques drawn from various schools of thought involving several treatment methods and allows the therapist to adapt to each client's individual needs. Wider application for eclectic approach is however limited in stroke rehabilitation. The objective is to find out whether eclectic approach improves upper extremity (UE) functional recovery in acute stroke rehabilitation. Twenty-five postacute unilateral supratentorial stroke subjects recruited from tertiary care hospitals recovered with Stage 2-5 in Brunnstorm stage of UE motor recovery (BRS-UE) underwent 45 min of eclectic approach for UE every day involving seven different treatment methods (5 min for each method) for 6 days consecutively. The outcome was UE subscale of the Fugl-Meyer Motor test (UE-FM), UE subscale of the Stroke Rehabilitation Assessment of Movement (UE-STREAM), Wolf Motor Function test (WMFT-FAS), and Stroke Impact Scale-16 (SIS-16) was collected at the end of the sixth session. All the participants showed significant improvement in all the outcome measures. The Stage 2 and 3 subjects showed UE-STREAM (P = 0.007) WMFT-FAS (P rehabilitation when the stroke occurs.

  1. Transient recovery voltage analysis for various current breaking mathematical models: shunt reactor and capacitor bank de-energization study

    Directory of Open Access Journals (Sweden)

    Oramus Piotr

    2015-09-01

    Full Text Available Electric arc is a complex phenomenon occurring during the current interruption process in the power system. Therefore performing digital simulations is often necessary to analyse transient conditions in power system during switching operations. This paper deals with the electric arc modelling and its implementation in simulation software for transient analyses during switching conditions in power system. Cassie, Cassie-Mayr as well as Schwarz-Avdonin equations describing the behaviour of the electric arc during the current interruption process have been implemented in EMTP-ATP simulation software and presented in this paper. The models developed have been used for transient simulations to analyse impact of the particular model and its parameters on Transient Recovery Voltage in different switching scenarios: during shunt reactor switching-off as well as during capacitor bank current switching-off. The selected simulation cases represent typical practical scenarios for inductive and capacitive currents breaking, respectively.

  2. Application of multiple sorption model to estimation of CO2 sequestration capacity or CH4 recovery in polish hard coals

    Directory of Open Access Journals (Sweden)

    Jodłowski Grzegorz

    2017-01-01

    Full Text Available The aim of the study is to estimate the theoretical capacity of coal deposits in terms of carbon dioxide storage and methane recovery estimate during the injection of carbon dioxide. The Multiple Sorption Model was used for this purpose. The range of sorption measurement data on which the simulations were based does not exceed the critical point for both methane and carbon dioxide. The model allows to calculate absorption, adsorption, expansion and total theoretical sorption. For further consideration absorption was used as the process of the percolation of the gas in the bulk of the coal matter as well as the total theoretical sorption, the occurrence of which is possible due to the presence of fractures in the coal seam. Calculated levels of absorption and the total theoretical adsorption were applied to estimate the possible storage capacity of carbon dioxide based on the data associated with the content of coal in the mining fields of individual Polish coal mines. Moreover, MSM development for the gas mixture sorption can be used to roughly assess the recovery of methane naturally occurring in coal deposits during such a process.

  3. Effects of processing on the recovery of food allergens from a model dark chocolate matrix.

    Science.gov (United States)

    Khuda, Sefat E; Jackson, Lauren S; Fu, Tong-Jen; Williams, Kristina M

    2015-02-01

    To alleviate the risk to allergic consumers, it is crucial to improve factors affecting the detection of food allergens in processed chocolate products. This study evaluated processing effects on (1) recovery of peanut, egg, and milk allergens using five different extraction buffers, and (2) identification of specific allergenic proteins from extracts of incurred chocolate using allergen-specific antibodies and human allergic sera. Immunochemical staining with polyclonal antibodies showed that the addition of detergent or reducing agent improved extraction efficiency of peanut proteins, but not of egg and milk proteins. Tempering decreased antibody binding regardless of extractant. Detection of IgE-reactive peanut, egg, and milk allergens was differentially affected by tempering and extractant. Detection problems associated with matrix and processing effects may be overcome by the choice of extraction buffer and detecting antibody.

  4. Energy-efficient recovery of butanol from model solutions and fermentation broth by adsorption.

    Science.gov (United States)

    Qureshi, N; Hughes, S; Maddox, I S; Cotta, M A

    2005-07-01

    This article discusses the separation of butanol from aqueous solutions and/or fermentation broth by adsorption. Butanol fermentation is also known as acetone butanol ethanol (ABE) or solvent fermentation. Adsorbents such as silicalite, resins (XAD-2, XAD-4, XAD-7, XAD-8, XAD-16), bone charcoal, activated charcoal, bonopore, and polyvinylpyridine have been studied. Use of silicalite appears to be the more attractive as it can be used to concentrate butanol from dilute solutions (5 to 790-810 g L(-1)) and results in complete desorption of butanol (or ABE). In addition, silicalite can be regenerated by heat treatment. The energy requirement for butanol recovery by adsorption-desorption processes has been calculated to be 1,948 kcal kg(-1) butanol as compared to 5,789 kcal kg(-1) butanol by steam stripping distillation. Other techniques such as gas stripping and pervaporation require 5,220 and 3,295 kcal kg(-1) butanol, respectively.

  5. Black liquor combustion validated recovery boiler modeling: Final year report. Volume 1 (Main text and Appendix I, sections 1--4)

    Energy Technology Data Exchange (ETDEWEB)

    Grace, T.M.; Frederick, W.J.; Salcudean, M.; Wessel, R.A.

    1998-08-01

    This project was initiated in October 1990, with the objective of developing and validating a new computer model of a recovery boiler furnace using a computational fluid dynamics (CFD) code specifically tailored to the requirements for solving recovery boiler flows, and using improved submodels for black liquor combustion based on continued laboratory fundamental studies. The key tasks to be accomplished were as follows: (1) Complete the development of enhanced furnace models that have the capability to accurately predict carryover, emissions behavior, dust concentrations, gas temperatures, and wall heat fluxes. (2) Validate the enhanced furnace models, so that users can have confidence in the predicted results. (3) Obtain fundamental information on aerosol formation, deposition, and hardening so as to develop the knowledge base needed to relate furnace model outputs to plugging and fouling in the convective sections of the boiler. (4) Facilitate the transfer of codes, black liquid submodels, and fundamental knowledge to the US kraft pulp industry. Volume 1 contains the main body of the report and the first 4 sections of Appendix 1: Modeling of black liquor recovery boilers -- summary report; Flow and heat transfer modeling in the upper furnace of a kraft recovery boiler; Numerical simulation of black liquor combustion; and Investigation of turbulence models and prediction of swirling flows for kraft recovery furnaces.

  6. Testing the validity of conflict drift-diffusion models for use in estimating cognitive processes: A parameter-recovery study.

    Science.gov (United States)

    White, Corey N; Servant, Mathieu; Logan, Gordon D

    2017-03-29

    Researchers and clinicians are interested in estimating individual differences in the ability to process conflicting information. Conflict processing is typically assessed by comparing behavioral measures like RTs or error rates from conflict tasks. However, these measures are hard to interpret because they can be influenced by additional processes like response caution or bias. This limitation can be circumvented by employing cognitive models to decompose behavioral data into components of underlying decision processes, providing better specificity for investigating individual differences. A new class of drift-diffusion models has been developed for conflict tasks, presenting a potential tool to improve analysis of individual differences in conflict processing. However, measures from these models have not been validated for use in experiments with limited data collection. The present study assessed the validity of these models with a parameter-recovery study to determine whether and under what circumstances the models provide valid measures of cognitive processing. Three models were tested: the dual-stage two-phase model (Hübner, Steinhauser, & Lehle, Psychological Review, 117(3), 759-784, 2010), the shrinking spotlight model (White, Ratcliff, & Starns, Cognitive Psychology, 63(4), 210-238, 2011), and the diffusion model for conflict tasks (Ulrich, Schröter, Leuthold, & Birngruber, Cogntive Psychology, 78, 148-174, 2015). The validity of the model parameters was assessed using different methods of fitting the data and different numbers of trials. The results show that each model has limitations in recovering valid parameters, but they can be mitigated by adding constraints to the model. Practical recommendations are provided for when and how each model can be used to analyze data and provide measures of processing in conflict tasks.

  7. Nitrate-Mediated Microbially Enhanced Oil Recovery (N-MEOR) from model upflow bioreactors.

    Science.gov (United States)

    Gassara, Fatma; Suri, Navreet; Voordouw, Gerrit

    2017-02-15

    Microbially Enhanced Oil Recovery (MEOR) can enhance oil production with less energy input and less costs than other technologies. The present study used different aqueous electron donors (acetate, glucose, molasses) and an aqueous electron acceptor (nitrate) to stimulate growth of heterotrophic nitrate reducing bacteria (hNRB) to improve production of oil. Initial flooding of columns containing heavy oil (viscosity of 3400cP at 20°C) with CSBK (Coleville synthetic brine medium) produced 0.5 pore volume (PV) of oil. Bioreactors were then inoculated with hNRB with 5.8g/L of molasses and 0, 10, 20, 40, 60 or 80mM nitrate, as well as with 17mM glucose or 57mM acetate and 80mM nitrate. During incubations no oil was produced in the bioreactors that received 5.8g/L of molasses and 0, 10, 20, 40 or 60mM nitrate. However, the bioreactors injected with 5.8g/L of molasses, 17mM glucose or 57mM acetate and 80mM nitrate produced 13.9, 11.3±3.1 and 17.8±6.6% of residual oil, respectively. The significant production of oil from these bioreactors may be caused by N2-CO2 gas production. Following continued injection with CSBK without nitrate, subsequent elution of significant residual oil (5-30%) was observed. These results also indicate possible involvement of fermentation products (organic acids, alcohols) to enhance heavy oil recovery. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Modeling and simulation of liquid-solid circulating fluidized bed ion exchange system for continuous protein recovery.

    Science.gov (United States)

    Mazumder, Jahirul; Zhu, Jingxu; Bassi, Amarjeet S; Ray, Ajay K

    2009-09-01

    Liquid-solid circulating fluidized bed (LSCFB) is an integrated two-column (downcomer and riser) system which can accommodate two separate processes (adsorption and desorption) in the same unit with continuous circulation of the solid particles between the two columns. In this study, a mathematical model based on the assumption of homogeneous fluidization was developed considering hydrodynamics, adsorption-desorption kinetics and liquid-solid mass transfer. The simulation results showed good agreement with the available experimental results for continuous protein recovery. A parametric sensitivity study was performed to better understand the influence of different operating parameters on the BSA adsorption and desorption capacity of the system. The model developed can easily be extended to other applications of LSCFB.

  9. Donor age dependent graft development and recovery in a rat model of Huntington's disease: histological and behavioral analysis.

    Science.gov (United States)

    Schackel, Stefanie; Pauly, Marie-Christin; Piroth, Tobias; Nikkhah, Guido; Döbrössy, Máté D

    2013-11-01

    Neural cell replacement therapy using fetal striatal cells has provided evidence of disease modification in clinical trials in Huntington's disease (HD) patients, although the results have been inconsistent. One of the contributing factors to the variable outcome could be the different capacity of transplanted cells derived from the primordial striatum to proliferate and maturate into striatal projection neurons. Based on the rodent lesion model of HD, the current study investigated how intrastriatal-striatal grafts from variable aged donors develop in vivo and how they influence functional recovery. Young adult female Sprague-Dawley rats were lesioned unilaterally in the dorso-striatum with quinolinic acid (0.12 M) and transplanted 14 days later with single cell suspension grafts equivalent of one whole ganglionic eminence (WGE) from donors of embryonic developmental age E13, E14, or E15; animals with or without striatal lesion served as controls. All animals were tested on the Cylinder and the Corridor tests, as well as on apomorphine-induced rotation at baseline, post-lesion/pre-grafting, and at 6 and 10 weeks post-grafting. A week prior to perfusion, a sub-group in each grafted group received fluorogold injections into the ipsilateral globus pallidus to study graft efferent projections. In summary, the data demonstrates that the age of the embryonic donor tissue has an impact on both the graft mediated functional recovery, and on the in vivo cellular composition of the striatal transplant. E13 tissue grafts gave the best overall outcome indicating that WGE from different donor ages have different potential to promote functional recovery. Understanding the stages and process in rodent striatal development could improve tissue selection in clinical trials of cell therapy in HD. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Comparison of the effects of erythropoietin and anakinra on functional recovery and gene expression in a traumatic brain injury model

    Directory of Open Access Journals (Sweden)

    Gail D Anderson

    2013-10-01

    Full Text Available The goal of this study was to compare the effects of two inflammatory modulators, erythropoietin (EPO and anakinra, on functional recovery and brain gene expression following a cortical contusion impact (CCI injury. Dosage regimens were designed to provide serum concentrations in the range obtained with clinically approved doses. Functional recovery was assessed using both motor and spatial learning tasks and neuropathological measurements conducted in the cortex and hippocampus. Microarray-based transcriptional profiling was used to determine the effect on gene expression at 24 h, 72 h and 7 days post-CCI. Ingenuity Pathway Analysis was used to evaluate the effect on relevant functional categories. EPO and anakinra treatment resulted in significant changes in brain gene expression in the CCI model demonstrating acceptable brain penetration. At all three time points, EPO treatment resulted in significantly more differentially expressed genes than anakinra. For anakinra at 24 h and EPO at 24 h, 72 h and 7 days, the genes in the top 3 functional categories were involved in cellular movement, inflammatory response and cell-to-cell signaling. For EPO, the majority of the genes in the top 10 canonical pathways identified were associated with inflammatory and immune signaling processes. This was true for anakinra only at 24 h post-traumatic brain injury (TBI. The immunomodulation effects of EPO and anakinra did not translate into positive effects on functional behavioral and lesion studies. Treatment with either EPO or anakinra failed to induce significant beneficial effects on recovery of function or produce any significant effects on the prevention of injury induced tissue loss at 30 days post-injury. In conclusion, treatment with EPO or anakinra resulted in significant effects on gene expression in the brain without affecting functional outcome. This suggests that targeting these inflammatory processes alone may not be sufficient for preventing

  11. Validation of a Waste Heat Recovery Model for a 1kW PEM Fuel Cell using Thermoelectric Generator

    Science.gov (United States)

    Saufi Sulaiman, M.; Mohamed, W. A. N. W.; Singh, B.; Fitrie Ghazali, M.

    2017-08-01

    Fuel cell is a device that generates electricity through electrochemical reaction between hydrogen and oxygen. A major by-product of the exothermic reaction is waste heat. The recovery of this waste heat has been subject to research on order to improve the overall energy utilization. However, nearly all of the studies concentrate on high temperature fuel cells using advanced thermodynamic cycles due to the high quality of waste heat. The method, characteristics and challenges in harvesting waste heat from a low temperature fuel cell using a direct energy conversion device is explored in this publication. A heat recovery system for an open cathode 1kW Proton Exchange Membrane fuel cell (PEM FC) was developed using a single unit of thermoelectric generator (TEG) attached to a heat pipe. Power output of the fuel cell was varied to obtain the performance of TEG at different stack temperatures. Natural and forced convections modes of cooling were applied to the TEG cold side. This is to simulate the conditions of a mini fuel cell vehicle at rest and in motion. The experimental results were analysed and a mathematical model based on the thermal circuit analogy was developed and compared. Forced convection mode resulted in higher temperature difference, output voltage and maximum power which are 3.3°C, 33.5 mV, and 113.96mW respectively. The heat recovery system for 1 kW Proton Exchange Membrane fuel cell (PEM FC) using single TEG was successfully established and improved the electrical production of fuel cell. Moreover, the experimental results obtained was in a good agreement with theoretical results.

  12. The difference between energy consumption and energy cost: Modelling energy tariff structures for water resource recovery facilities.

    Science.gov (United States)

    Aymerich, I; Rieger, L; Sobhani, R; Rosso, D; Corominas, Ll

    2015-09-15

    The objective of this paper is to demonstrate the importance of incorporating more realistic energy cost models (based on current energy tariff structures) into existing water resource recovery facilities (WRRFs) process models when evaluating technologies and cost-saving control strategies. In this paper, we first introduce a systematic framework to model energy usage at WRRFs and a generalized structure to describe energy tariffs including the most common billing terms. Secondly, this paper introduces a detailed energy cost model based on a Spanish energy tariff structure coupled with a WRRF process model to evaluate several control strategies and provide insights into the selection of the contracted power structure. The results for a 1-year evaluation on a 115,000 population-equivalent WRRF showed monthly cost differences ranging from 7 to 30% when comparing the detailed energy cost model to an average energy price. The evaluation of different aeration control strategies also showed that using average energy prices and neglecting energy tariff structures may lead to biased conclusions when selecting operating strategies or comparing technologies or equipment. The proposed framework demonstrated that for cost minimization, control strategies should be paired with a specific optimal contracted power. Hence, the design of operational and control strategies must take into account the local energy tariff.

  13. Vacuum Circuit Breaker Modelling for the Assessment of Transient Recovery Voltages Under Various Network Configurations

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Borghetti, Alberto; Glasdam, Jakob Bærholm

    2017-01-01

    for both VCB sizing and insulation coordination studies of the components nearby the switching device. In this respect, their accurate modelling, which is the object of the paper, becomes crucial. In particular, the paper presents (the concept of) a VCB model and two relevant applications showing the model......-known electromagnetic transient simulation environments, namely, EMTP-RV and PSCAD/EMTDC. The procedure adopted for the identification of the VCB model parameters is described....

  14. Report for the ASC CSSE L2 Milestone (4873) - Demonstration of Local Failure Local Recovery Resilient Programming Model.

    Energy Technology Data Exchange (ETDEWEB)

    Heroux, Michael Allen; Teranishi, Keita

    2014-06-01

    Recovery from process loss during the execution of a distributed memory parallel application is presently achieved by restarting the program, typically from a checkpoint file. Future computer system trends indicate that the size of data to checkpoint, the lack of improvement in parallel file system performance and the increase in process failure rates will lead to situations where checkpoint restart becomes infeasible. In this report we describe and prototype the use of a new application level resilient computing model that manages persistent storage of local state for each process such that, if a process fails, recovery can be performed locally without requiring access to a global checkpoint file. LFLR provides application developers with an ability to recover locally and continue application execution when a process is lost. This report discusses what features are required from the hardware, OS and runtime layers, and what approaches application developers might use in the design of future codes, including a demonstration of LFLR-enabled MiniFE code from the Matenvo mini-application suite.

  15. NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic model through trkA- and VEGFR2-dependent pathways.

    Science.gov (United States)

    Karatzas, Andreas; Katsanos, Konstantinos; Lilis, Ioannis; Papadaki, Helen; Kitrou, Panagiotis; Lecht, Shimon; Marcinkiewicz, Cezary; Siablis, Dimitris; Lelkes, Peter I; Lazarovici, Philip; Tsopanoglou, Nikos E

    2013-09-01

    Nerve growth factor (NGF) has been reported to play an important role in physiological and pathological angiogenesis. Based on these observations, we hypothesized that NGF may induce the formation of functional blood vessels in a hindlimb ischemic rabbit model. Hindlimb ischemia was induced in 34 rabbits bilaterally by endovascular embolization of femoral arteries. On the 7th, 14th, and 20th postembolization days, NGF was injected intramuscularly, in 1 ischemic limb, and vehicle was injected in the contralateral control limb. On the 40th day, newly developed collateral vessels (diameter >500 μm) were quantified by transauricular intraarterial subtraction angiography. Perfusion analysis of an in vivo dynamic computed tomography study was performed to the limbs to investigate the hemodynamic recovery of the distal ischemic tissues. Functional estimation of limb perfusion showed a statistically significant increase of blood flow and blood volume for NGF. However, the increase of the collateral vessels was not detectable angiographically, providing evidence for the existence of a NGF-stimulated capillary angiogenic network but not increase of arteriogenesis. The combination of NGF with either tropomyosin-related kinase type A or vascular endothelial growth factor receptor 2 antagonists abolished the NGF-induced hemodynamic recovery. These findings provide new insights into understanding the involvement of NGF in vascular formation and its applications in therapeutic angiogenesis.

  16. Economic analysis of electronic waste recycling: modeling the cost and revenue of a materials recovery facility in California.

    Science.gov (United States)

    Kang, Hai-Yong; Schoenung, Julie M

    2006-03-01

    The objectives of this study are to identify the various techniques used for treating electronic waste (e-waste) at material recovery facilities (MRFs) in the state of California and to investigate the costs and revenue drivers for these techniques. The economics of a representative e-waste MRF are evaluated by using technical cost modeling (TCM). MRFs are a critical element in the infrastructure being developed within the e-waste recycling industry. At an MRF, collected e-waste can become marketable output products including resalable systems/components and recyclable materials such as plastics, metals, and glass. TCM has two main constituents, inputs and outputs. Inputs are process-related and economic variables, which are directly specified in each model. Inputs can be divided into two parts: inputs for cost estimation and for revenue estimation. Outputs are the results of modeling and consist of costs and revenues, distributed by unit operation, cost element, and revenue source. The results of the present analysis indicate that the largest cost driver for the operation of the defined California e-waste MRF is the materials cost (37% of total cost), which includes the cost to outsource the recycling of the cathode ray tubes (CRTs) (dollar 0.33/kg); the second largest cost driver is labor cost (28% of total cost without accounting for overhead). The other cost drivers are transportation, building, and equipment costs. The most costly unit operation is cathode ray tube glass recycling, and the next are sorting, collecting, and dismantling. The largest revenue source is the fee charged to the customer; metal recovery is the second largest revenue source.

  17. Respiratory recovery following organophosphate poisoning in a rat model is suppressed by isolated hypoxia at the point of apnea.

    Science.gov (United States)

    Gaspari, Romolo J; Paydarfar, David

    2012-12-16

    Normal respiratory activity (eupnea) and gasping represent different types of respiratory activity, one of which is supported by oxygen (eupnea) and the other suppressed by oxygen (gasping). There is a loss of respiratory activity post-organophosphate (OP) poisoning that returns following treatment. It is not clear if post-OP respiratory activity represents eupnea or gasping. Depending on the type of respiratory activity, oxygenation during recovery from OP poisoning may have the potential to either support or suppress respiratory activity. We hypothesize that respiratory recovery following OP-induced central apnea represents a resumption of eupnea and is supported by oxygenation. We used an animal model of acute OP poisoning with detailed physiologic recordings. Animals were poisoned with dichlorvos and allowed to recover during a period of mechanical ventilation. Two experimental models were analyzed: (1) animals supported with 100% oxygen and (2) animals supported with a normoxic gas mixture titrated to a PaO(2) of 115 mmHg. Rats in this study demonstrated breathing that resumes spontaneously following OP-induced apnea with characteristics of both eupnea and gasping. The post-OP respiratory activity was suppressed by hypoxia, a characteristic of eupneic respiration and not gasping respiration. However, the respiratory rate during post-apneic breathing corresponded more closely to gasping. Analysis of phrenic nerve discharge activity was distinct from both eupnea and gasping, with peak inspiratory and post-inspiratory discharge activities significantly reduced compared to both eupnea and gasping. In summary, in this animal model post-apneic breathing distinct from eupnea and gasping that emerges following prolonged OP-induced central apnea is suppressed by hypoxia.

  18. Backup & Recovery

    CERN Document Server

    Preston, W

    2009-01-01

    Packed with practical, freely available backup and recovery solutions for Unix, Linux, Windows, and Mac OS X systems -- as well as various databases -- this new guide is a complete overhaul of Unix Backup & Recovery by the same author, now revised and expanded with over 75% new material.

  19. Recovery Online

    Science.gov (United States)

    Clark, John R.

    2007-01-01

    Since the founding of Alcoholics Anonymous (AA) in 1935, programs offering opportunity for recovery from alcoholism and other addictions have undergone vast changes. The Internet has created nearly limitless opportunities for recovering people and those seeking recovery to find both meetings and places where they can gather virtually and discuss…

  20. HEADING RECOVERY FROM OPTIC FLOW: COMPARING PERFORMANCE OF HUMANS AND COMPUTATIONAL MODELS

    Directory of Open Access Journals (Sweden)

    Andrew John Foulkes

    2013-06-01

    Full Text Available Human observers can perceive their direction of heading with a precision of about a degree. Several computational models of the processes underpinning the perception of heading have been proposed. In the present study we set out to assess which of four candidate models best captured human performance; the four models we selected reflected key differences in terms of approach and methods to modelling optic flow processing to recover movement parameters. We first generated a performance profile for human observers by measuring how performance changed as we systematically manipulated both the quantity (number of dots in the stimulus per frame and quality (amount of 2D directional noise of the flow field information. We then generated comparable performance profiles for the four candidate models. Models varied markedly in terms of both their performance and similarity to human data. To formally assess the match between the models and human performance we regressed the output of each of the four models against human performance data. We were able to rule out two models that produced very different performance profiles to human observers. The remaining two shared some similarities with human performance profiles in terms of the magnitude and pattern of thresholds. However none of the models tested could capture all aspect of the human data.

  1. A System Dynamics Model to Conserve Arid Region Water Resources through Aquifer Storage and Recovery in Conjunction with a Dam

    Directory of Open Access Journals (Sweden)

    Amir Niazi

    2014-08-01

    Full Text Available Groundwater depletion poses a significant threat in arid and semi-arid areas where rivers are usually ephemeral and groundwater is the major source of water. The present study investigated whether an effective water resources management strategy, capable of minimizing evaporative water losses and groundwater depletion while providing water for expanded agricultural activities, can be achieved through aquifer storage and recovery (ASR implemented in conjunction with water storage in an ephemeral river. A regional development modeling framework, including both ASR and a dam design developed through system dynamics modeling, was validated using a case study for the Sirik region of Iran. The system dynamics model of groundwater flow and the comprehensive system dynamics model developed in this study showed that ASR was a beneficial strategy for the region’s farmers and the groundwater system, since the rate of groundwater depletion declined significantly (from 14.5 meters per 40 years to three meters over the same period. Furthermore, evaporation from the reservoir decreased by 50 million cubic meters over the simulation period. It was concluded that the proposed system dynamics model is an effective tool in helping to conserve water resources and reduce depletion in arid regions and semi-arid areas.

  2. An Analytical Model for Simulating Heavy-Oil Recovery by Cyclic Steam Injection Using Horizontal Wells, SUPRI TR-118

    Energy Technology Data Exchange (ETDEWEB)

    Diwan, Utpal; Kovscek, Anthony R.

    1999-08-09

    In this investigation, existing analytical models for cyclic steam injection and oil recovery are reviewed and a new model is proposed that is applicable to horizontal wells. A new flow equation is developed for oil production during cyclic steaming of horizontal wells. The model accounts for the gravity-drainage of oil along the steam-oil interface and through the steam zone. Oil viscosity, effective permeability, geometry of the heated zone, porosity, mobile oil saturation, and thermal diffusivity of the reservoir influence the flow rate of oil in the model. The change in reservoir temperature with time is also modeled, and it results in the expected decline in oil production rate during the production cycle as the reservoir cools. Wherever appropriate, correlations and incorporated to minimize data requirements. A limited comparison to numerical simulation results agrees well, indicating that essential physics are successfully captured. Cyclic steaming appears to be a systematic met hod for heating a cold reservoir provided that a relatively uniform distribution of steam is obtained along the horizontal well during injection. A sensitivity analysis shows that the process is robust over the range of expected physical parameters.

  3. Simulation modeling for analysis of effectiveness and prime movers electrical energy demand of liquid coupled energy recovery systems

    Energy Technology Data Exchange (ETDEWEB)

    Ardehali, M.M. [Power and Energy Management Division, Department of Electrical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Ave, Tehran (Iran); Torfi, S. [Energy Systems Engineering Division, Department of Mechanical Engineering, KN Toosi University of Technology (Iran)

    2006-09-15

    Realization of anticipated energy efficiency from recuperative liquid coupled run-around energy recovery (LER) systems requires identification of the system components influential parameters and accounting for the prime movers energy requirements. Because simulation modeling is considered as an integral part of the design and economic evaluation of LER systems, it is essential to calibrate the developed models and validate the performance predictions by means of comparison with data from experimental measurements. The objective of this study is to develop a simulation model for a typical LER system that accounts for (a) energy loss from the interconnecting piping, (b) temperature dependency of thermophysical properties, (c) hydraulic pressure drop as a function of liquid Reynolds number and other related physical parameters, such as bends and bypass flow, (d) heat exchangers air side convective transfer coefficients based on recent correlations reported for wavy fins and (e) varying efficiency for prime movers. To achieve the objective, several simplifying assumptions used in previous studies have been relaxed; the interactions between all system components are mathematically modeled; and the latest correlations are utilized. The results from the simulation modeling of this study are found to be within 4% of the experimental data reported in the literature. Because of the dynamics introduced by the operation of the three way valve, controlling the pump and fan motors based on the bypass ratio is recommended, as it would result in better management of the electrical energy demand. (author)

  4. Detailed Modeling of Distillation Technologies for Closed-Loop Water Recovery Systems

    Science.gov (United States)

    Allada, Rama Kumar; Lange, Kevin E.; Anderson, Molly S.

    2011-01-01

    Detailed chemical process simulations are a useful tool in designing and optimizing complex systems and architectures for human life support. Dynamic and steady-state models of these systems help contrast the interactions of various operating parameters and hardware designs, which become extremely useful in trade-study analyses. NASA?s Exploration Life Support technology development project recently made use of such models to compliment a series of tests on different waste water distillation systems. This paper presents efforts to develop chemical process simulations for three technologies: the Cascade Distillation System (CDS), the Vapor Compression Distillation (VCD) system and the Wiped-Film Rotating Disk (WFRD) using the Aspen Custom Modeler and Aspen Plus process simulation tools. The paper discusses system design, modeling details, and modeling results for each technology and presents some comparisons between the model results and recent test data. Following these initial comparisons, some general conclusions and forward work are discussed.

  5. Predicting the resilience and recovery of aquatic systems: A framework for model evolution within environmental observatories

    Science.gov (United States)

    Hipsey, Matthew R.; Hamilton, David P.; Hanson, Paul C.; Carey, Cayelan C.; Coletti, Janaine Z.; Read, Jordan S.; Ibelings, Bas W.; Valesini, Fiona J.; Brookes, Justin D.

    2015-09-01

    Maintaining the health of aquatic systems is an essential component of sustainable catchment management, however, degradation of water quality and aquatic habitat continues to challenge scientists and policy-makers. To support management and restoration efforts aquatic system models are required that are able to capture the often complex trajectories that these systems display in response to multiple stressors. This paper explores the abilities and limitations of current model approaches in meeting this challenge, and outlines a strategy based on integration of flexible model libraries and data from observation networks, within a learning framework, as a means to improve the accuracy and scope of model predictions. The framework is comprised of a data assimilation component that utilizes diverse data streams from sensor networks, and a second component whereby model structural evolution can occur once the model is assessed against theoretically relevant metrics of system function. Given the scale and transdisciplinary nature of the prediction challenge, network science initiatives are identified as a means to develop and integrate diverse model libraries and workflows, and to obtain consensus on diagnostic approaches to model assessment that can guide model adaptation. We outline how such a framework can help us explore the theory of how aquatic systems respond to change by bridging bottom-up and top-down lines of enquiry, and, in doing so, also advance the role of prediction in aquatic ecosystem management.

  6. Predicting the resilience and recovery of aquatic systems: a framework for model evolution within environmental observatories

    Science.gov (United States)

    Hipsey, Matthew R.; Hamilton, David P.; Hanson, Paul C.; Carey, Cayelan C.; Coletti, Janaine Z; Read, Jordan S.; Ibelings, Bas W; Valensini, Fiona J; Brookes, Justin D

    2015-01-01

    Maintaining the health of aquatic systems is an essential component of sustainable catchmentmanagement, however, degradation of water quality and aquatic habitat continues to challenge scientistsand policy-makers. To support management and restoration efforts aquatic system models are requiredthat are able to capture the often complex trajectories that these systems display in response to multiplestressors. This paper explores the abilities and limitations of current model approaches in meeting this chal-lenge, and outlines a strategy based on integration of flexible model libraries and data from observationnetworks, within a learning framework, as a means to improve the accuracy and scope of model predictions.The framework is comprised of a data assimilation component that utilizes diverse data streams from sensornetworks, and a second component whereby model structural evolution can occur once the model isassessed against theoretically relevant metrics of system function. Given the scale and transdisciplinarynature of the prediction challenge, network science initiatives are identified as a means to develop and inte-grate diverse model libraries and workflows, and to obtain consensus on diagnostic approaches to modelassessment that can guide model adaptation. We outline how such a framework can help us explore thetheory of how aquatic systems respond to change by bridging bottom-up and top-down lines of enquiry,and, in doing so, also advance the role of prediction in aquatic ecosystem management.

  7. On a three-layer Hele-Shaw model of enhanced oil recovery with a linear viscous profile

    CERN Document Server

    Daripa, Prabir; Meneses, Rodrigo

    2015-01-01

    We present a non-standard eigenvalue problem that arises in the linear stability of a three-layer Hele-Shaw model of enhanced oil recovery. A nonlinear transformation is introduced which allows reformulation of the non-standard eigenvalue problem as a boundary value problem for Kummer's equation when the viscous profile of the middle layer is linear. Using the existing body of works on Kummer's equation, we construct an exact solution of the eigenvalue problem and provide the dispersion relation implicitly through the existence criterion for the non-trivial solution. We also discuss the convergence of the series solution. It is shown that this solution reduces to the physically relevant solutions in two asymptotic limits: (i) when the linear viscous profile approaches a constant viscous profile; or (ii) when the length of the middle layer approaches zero.

  8. Piloted Simulation Evaluation of a Model-Predictive Automatic Recovery System to Prevent Vehicle Loss of Control on Approach

    Science.gov (United States)

    Litt, Jonathan S.; Liu, Yuan; Sowers, Thomas S.; Owen, A. Karl; Guo, Ten-Huei

    2014-01-01

    This paper describes a model-predictive automatic recovery system for aircraft on the verge of a loss-of-control situation. The system determines when it must intervene to prevent an imminent accident, resulting from a poor approach. It estimates the altitude loss that would result from a go-around maneuver at the current flight condition. If the loss is projected to violate a minimum altitude threshold, the maneuver is automatically triggered. The system deactivates to allow landing once several criteria are met. Piloted flight simulator evaluation showed the system to provide effective envelope protection during extremely unsafe landing attempts. The results demonstrate how flight and propulsion control can be integrated to recover control of the vehicle automatically and prevent a potential catastrophe.

  9. Radial Basis Function Neural Networks-Based Modeling of the Membrane Separation Process: Hydrogen Recovery from Refinery Gases

    Institute of Scientific and Technical Information of China (English)

    Lei Wang; Cheng Shao; Hai Wang; Hong Wu

    2006-01-01

    Membrane technology has found wide applications in the petrochemical industry, mainly in the purification and recovery of the hydrogen resources. Accurate prediction of the membrane separation performance plays an important role in carrying out advanced process control (APC). For the first time, a soft-sensor model for the membrane separation process has been established based on the radial basis function (RBF) neural networks. The main performance parameters, i.e, permeate hydrogen concentration, permeate gas flux, and residue hydrogen concentration, are estimated quantitatively by measuring the operating temperature, feed-side pressure, permeate-side pressure, residue-side pressure, feed-gas flux, and feed-hydrogen concentration excluding flow structure, membrane parameters, and other compositions. The predicted results can gain the desired effects. The effectiveness of this novel approach lays a foundation for integrating control technology and optimizing the operation of the gas membrane separation process.

  10. Recovery model of temporary threshold shifts from exposures with the same L_Aeq,T and different frequency components

    DEFF Research Database (Denmark)

    Ordonez, Rodrigo; Hammershøi, Dorte

    2005-01-01

    Temporary Threshold Shifts (TTS) were determined for 9 subjects exposed to three different band-passed signals taken from one channel of a binaural recording of an industrial mill. The three 2-octave bands were: Low (125 to 500 Hz), mid (500 Hz to 2 kHz), and high (2 kHz to 8 kHz). The band......-passed signals were adjusted to give the same equivalent A-weighted sound exposure according to ISO-1999 (1990) and were presented to one ear of the subjects in three separate experimental sessions. The results were used in a recovery model based on a least-squares fit of the data to a superposition...

  11. Non-negative least squares for high-dimensional linear models: consistency and sparse recovery without regularization

    CERN Document Server

    Slawski, Martin

    2012-01-01

    Least squares fitting is in general not useful for high-dimensional linear models, in which the number of predictors is of the same or even larger order of magnitude than the number of samples. Theory developed in recent years has coined a paradigm according to which sparsity-promoting regularization is regarded as a necessity in such setting. Deviating from this paradigm, we show that non-negativity constraints on the regression coefficients may be similarly effective as explicit regularization. For a broad range of designs with Gram matrix having non-negative entries, we establish bounds on the $\\ell_2$-prediction error of non-negative least squares (NNLS) whose form qualitatively matches corresponding results for $\\ell_1$-regularization. Under slightly stronger conditions, it is established that NNLS followed by hard thresholding performs excellently in terms of support recovery of an (approximately) sparse target, in some cases improving over $\\ell_1$-regularization. A substantial advantage of NNLS over r...

  12. Clinical experiences utilizing wireless remote control and an ASP model backup archive for a disaster recovery event

    Science.gov (United States)

    Liu, Brent J.; Documet, Luis; Documet, Jorge; Huang, H. K.; Muldoon, Jean

    2004-04-01

    An Application Service Provider (ASP) archive model for disaster recovery for Saint John"s Health Center (SJHC) clinical PACS data has been implemented using a Fault-Tolerant Archive Server at the Image Processing and Informatics Laboratory, Marina del Rey, CA (IPIL) since mid-2002. The purpose of this paper is to provide clinical experiences with the implementation of an ASP model backup archive in conjunction with handheld wireless technologies for a particular disaster recovery scenario, an earthquake, in which the local PACS archive and the hospital are destroyed and the patients are moved from one hospital to another. The three sites involved are: (1) SJHC, the simulated disaster site; (2) IPIL, the ASP backup archive site; and (3) University of California, Los Angeles Medical Center (UCLA), the relocated patient site. An ASP backup archive has been established at IPIL to receive clinical PACS images daily using a T1 line from SJHC for backup and disaster recovery storage. Procedures were established to test the network connectivity and data integrity on a regular basis. In a given disaster scenario where the local PACS archive has been destroyed and the patients need to be moved to a second hospital, a wireless handheld device such as a Personal Digital Assistant (PDA) can be utilized to route images to the second hospital site with a PACS and reviewed by radiologists. To simulate this disaster scenario, a wireless network was implemented within the clinical environment in all three sites: SJHC, IPIL, and UCLA. Upon executing the disaster scenario, the SJHC PACS archive server simulates a downtime disaster event. Using the PDA, the radiologist at UCLA can query the ASP backup archive server at IPIL for PACS images and route them directly to UCLA. Implementation experiences integrating this solution within the three clinical environments as well as the wireless performance are discussed. A clinical downtime disaster scenario was implemented and successfully

  13. Developing a Robust Surrogate Model of Chemical Flooding Based on the Artificial Neural Network for Enhanced Oil Recovery Implications

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Ahmadi

    2015-01-01

    Full Text Available Application of chemical flooding in petroleum reservoirs turns into hot topic of the recent researches. Development strategies of the aforementioned technique are more robust and precise when we consider both economical points of view (net present value, NPV and technical points of view (recovery factor, RF. In current study many attempts have been made to propose predictive model for estimation of efficiency of chemical flooding in oil reservoirs. To gain this end, a couple of swarm intelligence and artificial neural network (ANN is employed. Also, lucrative and high precise chemical flooding data banks reported in previous attentions are utilized to test and validate proposed intelligent model. According to the mean square error (MSE, correlation coefficient, and average absolute relative deviation, the suggested swarm approach has acceptable reliability, integrity and robustness. Thus, the proposed intelligent model can be considered as an alternative model to predict the efficiency of chemical flooding in oil reservoir when the required experimental data are not available or accessible.

  14. Model suggests potential for Porites coral population recovery after removal of anthropogenic disturbance (Luhuitou, Hainan, South China Sea)

    Science.gov (United States)

    Zhao, Meixia; Riegl, Bernhard; Yu, Kefu; Shi, Qi; Zhang, Qiaomin; Liu, Guohui; Yang, Hongqiang; Yan, Hongqiang

    2016-09-01

    Population models are important for resource management and can inform about potential trajectories useful for planning purposes, even with incomplete monitoring data. From size frequency data on Luhuitou fringing reef, Hainan, South China Sea, a matrix population model of massive corals (Porites lutea) was developed and trajectories over 100 years under no disturbance and random disturbances were projected. The model reflects a largely open population of Porites lutea, with low local recruitment and preponderance of imported recruitment. Under no further disturbance, the population of Porites lutea will grow and its size structure will change from predominance of small size classes to large size classes. Therewith, total Porites cover will increase. Even under random disturbances every 10 to 20 years, the Porites population could remain viable, albeit at lower space cover. The models suggest recovery at Luhuitou following the removal of chronic anthropogenic disturbance. Extending the area of coral reef reserves to protect the open coral community and the path of connectivity is advisable and imperative for the conservation of Hainan’s coral reefs.

  15. Viscous properties of polyacrylamide solutions used for enhanced oil recovery and comparison with different rheological models

    Energy Technology Data Exchange (ETDEWEB)

    Lakatos, I.; Lakatos-Szabo, J.; Schurz, J.

    1987-09-01

    Six different rheological models were applied for description of viscous properties of polyacrylamide solutions in the low shear rate range. Non of the formulas evaluated has universal applicability despite theoretical interpretation and the 'constants' in the models proved hardly physically founded, but they can rather be used as 'fitting constants' in a formal way. The best coincidence was obtained between the measured and the calculated data with the Carreau's model which is also proposed for incorporation of the rheological properties of polyacrylamide solutions into mathematical simulators of polymer and polymer-micellar flooding.

  16. A geospatial modelling approach to predict seagrass habitat recovery under multiple stressor regimes

    Science.gov (United States)

    Restoration of estuarine seagrass habitats requires a clear understanding of the modes of action of multiple interacting stressors including nutrients, climate change, coastal land-use change, and habitat modification. We have developed and demonstrated a geospatial modeling a...

  17. Modeling post-fire hydro-geomorphic recovery in the Waldo Canyon Fire

    Science.gov (United States)

    Kinoshita, Alicia; Nourbakhshbeidokhti, Samira; Chin, Anne

    2016-04-01

    Wildfire can have significant impacts on watershed hydrology and geomorphology by changing soil properties and removing vegetation, often increasing runoff and soil erosion and deposition, debris flows, and flooding. Watershed systems may take several years or longer to recover. During this time, post-fire channel changes have the potential to alter hydraulics that influence characteristics such as time of concentration and increase time to peak flow, flow capacity, and velocity. Using the case of the 2012 Waldo Canyon Fire in Colorado (USA), this research will leverage field-based surveys and terrestrial Light Detection and Ranging (LiDAR) data to parameterize KINEROS2 (KINematic runoff and EROSion), an event oriented, physically-based watershed runoff and erosion model. We will use the Automated Geospatial Watershed Assessment (AGWA) tool, which is a GIS-based hydrologic modeling tool that uses commonly available GIS data layers to parameterize, execute, and spatially visualize runoff and sediment yield for watersheds impacted by the Waldo Canyon Fire. Specifically, two models are developed, an unburned (Bear Creek) and burned (Williams) watershed. The models will simulate burn severity and treatment conditions. Field data will be used to validate the burned watersheds for pre- and post-fire changes in infiltration, runoff, peak flow, sediment yield, and sediment discharge. Spatial modeling will provide insight into post-fire patterns for varying treatment, burn severity, and climate scenarios. Results will also provide post-fire managers with improved hydro-geomorphic modeling and prediction tools for water resources management and mitigation efforts.

  18. Quasi-Monte Carlo based global uncertainty and sensitivity analysis in modeling free product migration and recovery from petroleum-contaminated aquifers.

    Science.gov (United States)

    He, Li; Huang, Gordon; Lu, Hongwei; Wang, Shuo; Xu, Yi

    2012-06-15

    This paper presents a global uncertainty and sensitivity analysis (GUSA) framework based on global sensitivity analysis (GSA) and generalized likelihood uncertainty estimation (GLUE) methods. Quasi-Monte Carlo (QMC) is employed by GUSA to obtain realizations of uncertain parameters, which are then input to the simulation model for analysis. Compared to GLUE, GUSA can not only evaluate global sensitivity and uncertainty of modeling parameter sets, but also quantify the uncertainty in modeling prediction sets. Moreover, GUSA's another advantage lies in alleviation of computational effort, since those globally-insensitive parameters can be identified and removed from the uncertain-parameter set. GUSA is applied to a practical petroleum-contaminated site in Canada to investigate free product migration and recovery processes under aquifer remediation operations. Results from global sensitivity analysis show that (1) initial free product thickness has the most significant impact on total recovery volume but least impact on residual free product thickness and recovery rate; (2) total recovery volume and recovery rate are sensitive to residual LNAPL phase saturations and soil porosity. Results from uncertainty predictions reveal that the residual thickness would remain high and almost unchanged after about half-year of skimmer-well scheme; the rather high residual thickness (0.73-1.56 m 20 years later) indicates that natural attenuation would not be suitable for the remediation. The largest total recovery volume would be from water pumping, followed by vacuum pumping, and then skimmer. The recovery rates of the three schemes would rapidly decrease after 2 years (less than 0.05 m(3)/day), thus short-term remediation is not suggested. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. A unified model for prediction of CSOR in steam-based bitumen recovery

    Energy Technology Data Exchange (ETDEWEB)

    Edmunds, N.; Peterson, J. [Laricina Energy Ltd., Calgary, AB (Canada)

    2007-07-01

    A model was used to estimate the cumulative steam-oil ratio (CSOR) of steam assisted gravity drainage (SAGD) processes in high-permeability reservoirs. The aim of the model was to correlate the CSOR performance of current SAGD projects against single reservoir variables, and was designed for use in evaluations and economic analyses. The model assumed that depletion was gravity driven, and that produced oil from the steam zone was uniformly reduced to residual oil saturation. An empirical constant was used to account for heat stored below the chamber as a factor of the overburden transient losses. CSOR was predicted as a function of time. Model parameters were tested at EnCana's Foster Creek McMurray project and at Canadian Natural Resources' Primrose Grand Rapids site, while CSS data were obtained from the Cold Lake Clearwater project. The model was then used to compare SAGD and CSS projects. Results showed that vertical-radial geometry was thermally inefficient when compared to the horizontal trough used in SAGD operations. Vertical CSS methods also made inefficient use of the gravity potential of oil, due to the radial inflow constriction in the near-wellbore region. It was concluded that horizontal drainage geometry was able to sustain higher production rates at higher bottom hole viscosities.10 refs., 2 tabs., 9 figs.

  20. The GEOS Chemistry Climate Model: Implications of Climate Feedbacks on Ozone Depletion and Recovery

    Science.gov (United States)

    Stolarski, Richard S.; Pawson, Steven; Douglass, Anne R.; Newman, Paul A.; Kawa, S. Randy; Nielsen, J. Eric; Rodriquez, Jose; Strahan, Susan; Oman, Luke; Waugh, Darryn

    2008-01-01

    The Goddard Earth Observing System Chemistry Climate Model (GEOS CCM) has been developed by combining the atmospheric chemistry and transport modules developed over the years at Goddard and the GEOS general circulation model, also developed at Goddard. The first version of the model was used in the CCMVal intercomparison exercises that contributed to the 2006 WMO/UNEP Ozone Assessment. The second version incorporates the updated version of the GCM (GEOS 5) and will be used for the next round of CCMVal evaluations and the 2010 Ozone Assessment. The third version, now under development, incorporates the combined stratosphere and troposphere chemistry package developed under the Global Modeling Initiative (GMI). We will show comparison to past observations that indicate that we represent the ozone trends over the past 30 years. We will also show the basic temperature, composition, and dynamical structure of the simulations. We will further show projections into the future. We will show results from an ensemble of transient and time-slice simulations, including simulations with fixed 1960 chlorine, simulations with a best guess scenario (Al), and simulations with extremely high chlorine loadings. We will discuss planned extensions of the model to include emission-based boundary conditions for both anthropogenic and biogenic compounds.

  1. Economic and Environmental Analysis of Thermoelectric Waste Heat Recovery in Conventional Vehicles Operated in Korea: A Model Study

    Science.gov (United States)

    Bang, S.; Kim, B.; Youn, N.; Kim, Y. K.; Wee, D.

    2016-03-01

    Thermoelectric (TE) waste heat recovery from automotive exhaust streams is a potential technology that can significantly increase the overall efficiency of vehicles and subsequently reduce the consumption of fossil fuels. By reducing the consumption of fossil fuels, vehicular application of TE generators may also potentially reduce the emission of greenhouse gases (GHGs) and other air pollutants from the transportation sector. In this study, we analyse the economic benefit and feasibility of TE waste heat recovery systems in conventional vehicles operated in Korea by analytically modeling related vehicle systems and by analyzing driving patterns in urban environments. The economic effects of the associated efficiency improvement and the reduction of GHGs and air pollutants are simultaneously considered. Vehicular application of a TE generator may reduce 0.15 kL/year for a mid-size sedan and 1.04 kL/year for a medium-duty truck through fuel savings at a typical driving speed of 80 km/h. Based on the benefit-cost ratio analysis, it is shown that the economically acceptable costs of TE waste heat recovery systems are 744 /kW for the mid-size sedan and 2905 /kW for the medium-duty truck, respectively, when an operation period of 10 years is assumed. In terms of GHGs and air pollutants, the reduction annually amounts to 0.334 tCO2e of GHGs, 0.142 kg of CO, 0.00290 kg of VOC, 0.0150 kg of NO X , 0.198 kg of NH3, and 0.00006 kg of SO X for the mid-size sedan, while 2.65 tCO2e of GHGs, 1.974 kg of CO, 0.401 kg of VOC, 6.98 kg of NO X , 0.00034 kg of NH3, and 0.00229 kg of SO X can be annually reduced by applying a TE generator in the medium-duty truck.

  2. Integrated, multidisciplinary reservoir characterization, modeling and engineering leading to enhanced oil recovery from the Midway-Sunset field, California

    Energy Technology Data Exchange (ETDEWEB)

    Schamel, S.; Forster, C.; Deo, M. (Univ. of Utah, Salt Lake City, UT (United States)) (and others)

    1996-01-01

    The Pru Fee property is developed in a heavy oil, Class III (slope and basin clastic sand), reservoir of the Midway-Sunset field, San Joaquin Basin, California. Wells on the property were shut-in with an estimated 85% of the original oil remaining in place because the reservoir failed to respond to conventional cyclic steaming. Producibility problems are attributed to the close proximity of the property to the margin of the field. Specific problems include complex reservoir geometry, thinning pay, bottom water, and dipping beds. These problems are likely common at the margins of the Midway-Sunset and other Class III reservoirs. This project forms the first step in returning the property to production and explores strategies that might be applied elsewhere. Reservoir characterization, modeling, and engineering methods are integrated to design, simulate, and implement a pilot steam flood. A new drillhole provides good quality, core through the pay zone and a full suite of geophysical logs. Correlations between geological and petrophysical data are used to extrapolate reservoir conditions from older logs and yield a 3-dimensional petrophysical model. Numerical results illustrate how each producibility problem might influence production and provide a framework for designing the pilot steam flood. This first phase illustrates how a multidisciplinary team can use established technologies in developing the detailed petrophysical, geological, and numerical models needed to enhance oil recovery from marginal areas of Class III reservoirs.

  3. Integrated, multidisciplinary reservoir characterization, modeling and engineering leading to enhanced oil recovery from the Midway-Sunset field, California

    Energy Technology Data Exchange (ETDEWEB)

    Schamel, S.; Forster, C.; Deo, M. [Univ. of Utah, Salt Lake City, UT (United States)] [and others

    1996-12-31

    The Pru Fee property is developed in a heavy oil, Class III (slope and basin clastic sand), reservoir of the Midway-Sunset field, San Joaquin Basin, California. Wells on the property were shut-in with an estimated 85% of the original oil remaining in place because the reservoir failed to respond to conventional cyclic steaming. Producibility problems are attributed to the close proximity of the property to the margin of the field. Specific problems include complex reservoir geometry, thinning pay, bottom water, and dipping beds. These problems are likely common at the margins of the Midway-Sunset and other Class III reservoirs. This project forms the first step in returning the property to production and explores strategies that might be applied elsewhere. Reservoir characterization, modeling, and engineering methods are integrated to design, simulate, and implement a pilot steam flood. A new drillhole provides good quality, core through the pay zone and a full suite of geophysical logs. Correlations between geological and petrophysical data are used to extrapolate reservoir conditions from older logs and yield a 3-dimensional petrophysical model. Numerical results illustrate how each producibility problem might influence production and provide a framework for designing the pilot steam flood. This first phase illustrates how a multidisciplinary team can use established technologies in developing the detailed petrophysical, geological, and numerical models needed to enhance oil recovery from marginal areas of Class III reservoirs.

  4. Analysis of petroleum contaminated soils by spectral modeling and pure response profile recovery of n-hexane.

    Science.gov (United States)

    Chakraborty, Somsubhra; Weindorf, David C; Li, Bin; Ali, Md Nasim; Majumdar, K; Ray, D P

    2014-07-01

    This pilot study compared penalized spline regression (PSR) and random forest (RF) regression using visible and near-infrared diffuse reflectance spectroscopy (VisNIR DRS) derived spectra of 164 petroleum contaminated soils after two different spectral pretreatments [first derivative (FD) and standard normal variate (SNV) followed by detrending] for rapid quantification of soil petroleum contamination. Additionally, a new analytical approach was proposed for the recovery of the pure spectral and concentration profiles of n-hexane present in the unresolved mixture of petroleum contaminated soils using multivariate curve resolution alternating least squares (MCR-ALS). The PSR model using FD spectra (r(2) = 0.87, RMSE = 0.580 log10 mg kg(-1), and residual prediction deviation = 2.78) outperformed all other models tested. Quantitative results obtained by MCR-ALS for n-hexane in presence of interferences (r(2) = 0.65 and RMSE 0.261 log10 mg kg(-1)) were comparable to those obtained using FD (PSR) model. Furthermore, MCR ALS was able to recover pure spectra of n-hexane.

  5. Market potential of solar thermal enhanced oil recovery-a techno-economic model for Issaran oil field in Egypt

    Science.gov (United States)

    Gupta, Sunay; Guédez, Rafael; Laumert, Björn

    2017-06-01

    Solar thermal enhanced oil recovery (S-EOR) is an advanced technique of using concentrated solar power (CSP) technology to generate steam and recover oil from maturing oil reservoirs. The generated steam is injected at high pressure and temperature into the reservoir wells to facilitate oil production. There are three common methods of steam injection in enhanced oil recovery - continuous steam injection, cyclic steam stimulation (CSS) and steam assisted gravity drainage (SAGD). Conventionally, this steam is generated through natural gas (NG) fired boilers with associated greenhouse gas emissions. However, pilot projects in the USA (Coalinga, California) and Oman (Miraah, Amal) demonstrated the use of S-EOR to meet their steam requirements despite the intermittent nature of solar irradiation. Hence, conventional steam based EOR projects under the Sunbelt region can benefit from S-EOR with reduced operational expenditure (OPEX) and increased profitability in the long term, even with the initial investment required for solar equipment. S-EOR can be realized as an opportunity for countries not owning any natural gas resources to make them less energy dependent and less sensible to gas price fluctuations, and for countries owning natural gas resources to reduce their gas consumption and export it for a higher margin. In this study, firstly, the market potential of S-EOR was investigated worldwide by covering some of the major ongoing steam based EOR projects as well as future projects in pipeline. A multi-criteria analysis was performed to compare local conditions and requirements of all the oil fields based on a defined set of parameters. Secondly, a modelling approach for S-EOR was designed to identify cost reduction opportunities and optimum solar integration techniques, and the Issaran oil field in Egypt was selected for a case study to substantiate the approach. This modelling approach can be consulted to develop S-EOR projects for any steam flooding based oil

  6. Stall Recovery in a Centrifuge-Based Flight Simulator With an Extended Aerodynamic Model

    NARCIS (Netherlands)

    Ledegang, W.D.; Groen, E.L.

    2015-01-01

    We investigated the performance of 12 airline pilots in recovering from an asymmetrical stall in a flight simulator featuring an extended aerodynamic model of a transport-category aircraft, and a centrifuge-based motion platform capable of generating enhanced buffet motion and g-cueing. All pilots h

  7. A Model for Determining Modular Heat Recovery Incinerator Feasibility on Air Force Installations.

    Science.gov (United States)

    1992-09-01

    electrostatic precipitators downstream of spray 34 dryers or dry sorbent injectors to enhance particulate control (22:13-14). Low RQ0 Combustion. Fuels...of the model. Since this questionnaire was developed through a literature review, a research technique such as the Delphi technique could help to

  8. Modeling log-compressed ultrasound images for radio frequency signal recovery.

    Science.gov (United States)

    Seabra, José; Sanches, João

    2008-01-01

    This paper presents an algorithm for recovering the radio frequency (RF) signal provided by the ultrasound probe from the log-compressed ultrasound images displayed in ultrasound equipment. Commercial ecographs perform nonlinear image compression to reduce the dynamic range of the Ultrasound (US) signal in order to improve image visualization. Moreover, the clinician may adjust other parameters, such as brightness, gain and contrast, to improve image quality of a given anatomical detail. These operations significantly change the statistical distribution of the original RF raw signal, which is assumed, based on physical considerations on the signal formation process, to be Rayleigh distributed. Therefore, the image pixels are no longer Rayleigh distributed and the RF signal is not usually available in the common ultrasound equipment. For statistical data processing purposes, more important than having "good looking" images, it is important to have realistic models to describe the data. In this paper, a nonlinear compression parametric function is used to model the pre-processed image in order to recover the original RF image as well the contrast and brightness parameters. Tests using synthetic and real data and statistical measures such as the Kolmogorov-Smirnov and Kullback-Leibler divergences are used to assess the results. It is shown that the proposed estimation model clearly represents better the observed data than by taking the general assumption of the data being modeled by a Rayleigh distribution.

  9. Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor

    Science.gov (United States)

    The paper reports on the effects of a model aromatase inhibitor, fadrozole, on molecular and biochemical endpoints within the fathead minnow reproductive axis. Unlike previous studies, this work incorporated extensive time-course characterization over the course of an 8 d exposu...

  10. Testing Predictions of the Interactive Activation Model in Recovery from Aphasia after Treatment

    Science.gov (United States)

    Jokel, Regina; Rochon, Elizabeth; Leonard, Carol

    2004-01-01

    This paper presents preliminary results of pre- and post-treatment error analysis from an aphasic patient with anomia. The Interactive Activation (IA) model of word production (Dell, Schwartz, Martin, Saffran, & Gagnon, 1997) is utilized to make predictions about the anticipated changes on a picture naming task and to explain emerging patterns.…

  11. Automated recovery of three-dimensional models of plant shoots from multiple color images.

    Science.gov (United States)

    Pound, Michael P; French, Andrew P; Murchie, Erik H; Pridmore, Tony P

    2014-12-01

    Increased adoption of the systems approach to biological research has focused attention on the use of quantitative models of biological objects. This includes a need for realistic three-dimensional (3D) representations of plant shoots for quantification and modeling. Previous limitations in single-view or multiple-view stereo algorithms have led to a reliance on volumetric methods or expensive hardware to record plant structure. We present a fully automatic approach to image-based 3D plant reconstruction that can be achieved using a single low-cost camera. The reconstructed plants are represented as a series of small planar sections that together model the more complex architecture of the leaf surfaces. The boundary of each leaf patch is refined using the level-set method, optimizing the model based on image information, curvature constraints, and the position of neighboring surfaces. The reconstruction process makes few assumptions about the nature of the plant material being reconstructed and, as such, is applicable to a wide variety of plant species and topologies and can be extended to canopy-scale imaging. We demonstrate the effectiveness of our approach on data sets of wheat (Triticum aestivum) and rice (Oryza sativa) plants as well as a unique virtual data set that allows us to compute quantitative measures of reconstruction accuracy. The output is a 3D mesh structure that is suitable for modeling applications in a format that can be imported in the majority of 3D graphics and software packages. © 2014 American Society of Plant Biologists. All Rights Reserved.

  12. The effect of timing of decompression on neurologic recovery and histopathologic findings after spinal cord compression in a rat model.

    Directory of Open Access Journals (Sweden)

    Seyed Behzad Jazayeri

    2013-07-01

    Full Text Available Prior animal models have shown that rats sustaining 3-second immediate spinal cord compression had significantly better functional recovery and smaller lesion volumes than rats subjected to compression times of 1 hour, 6 hours, 3 weeks, and 10 weeks after spinal cord injury. We compare locomotor rating scales and spinal cord histopathology after 3 seconds and 10 minute compression times. . Ten rats were assigned into two early (3-second and late (10-minute compressive surgery groups. Compressive injury was produced using an aneurysmal clip method. Rats were followed-up for 11 weeks, and behavioral assessment was done by inclined plane test and tail-flick reflex. At the end of the study, the rats were sacrificed, and spinal cord specimens were studied in light and EM. Basso, Beattie and Bresnahan (BBB locomotor rating scales were significantly better in the early compression group after the 4th week of evaluation (P<0.05 and persisted throughout the remainder of the study. Histopathology demonstrated decreased normal tissue, more severe gliosis and cystic formation in the late group compared to the early group (P<0.05. In EM study, injuries in the late group including injury to the myelin and axon were more severe than the early compression group, and there was more cytoplasmic edema in the late compression group. Spinal cord injury secondary to 3-second compression improves functional motor recovery, spares more functional tissue, and is associated with less intracellular edema, less myelin and axon damage and more myelin regeneration in rats compared to those with 10 minutes of compression. Inclined plane test and tail-flick reflex had no significant difference.

  13. Nonlinear Inverse Problem for an Ion-Exchange Filter Model: Numerical Recovery of Parameters

    Directory of Open Access Journals (Sweden)

    Balgaisha Mukanova

    2015-01-01

    Full Text Available This paper considers the problem of identifying unknown parameters for a mathematical model of an ion-exchange filter via measurement at the outlet of the filter. The proposed mathematical model consists of a material balance equation, an equation describing the kinetics of ion-exchange for the nonequilibrium case, and an equation for the ion-exchange isotherm. The material balance equation includes a nonlinear term that depends on the kinetics of ion-exchange and several parameters. First, a numerical solution of the direct problem, the calculation of the impurities concentration at the outlet of the filter, is provided. Then, the inverse problem, finding the parameters of the ion-exchange process in nonequilibrium conditions, is formulated. A method for determining the approximate values of these parameters from the impurities concentration measured at the outlet of the filter is proposed.

  14. The Effects of Exercise on Cognitive Recovery after Acquired Brain Injury in Animal Models

    DEFF Research Database (Denmark)

    Wogensen, Elise; Rytter, Hana Malá; Mogensen, Jesper

    2015-01-01

    The objective of the present paper is to review the current status of exercise as a tool to promote cognitive rehabilitation after acquired brain injury (ABI) in animal model-based research. Searches were conducted on the PubMed, Scopus, and psycINFO databases in February 2014. Search strings used...... were: exercise (and) animal model (or) rodent (or) rat (and) traumatic brain injury (or) cerebral ischemia (or) brain irradiation. Studies were selected if they were (1) in English, (2) used adult animals subjected to acquired brain injury, (3) used exercise as an intervention tool after inflicted...... injury, (4) used exercise paradigms demanding movement of all extremities, (5) had exercise intervention effects that could be distinguished from other potential intervention effects, and (6) contained at least one measure of cognitive and/or emotional function. Out of 2308 hits, 22 publications...

  15. Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model

    OpenAIRE

    Ma, Junning; Gao, Junwei; Hou, Boru; Liu, Jixing; Chen, Sihua; Yan, Guizhong; Ren, Haijun

    2015-01-01

    Stem cell-based therapy provides a promising approach for treat stroke. Neural stem cells isolated from mice hippocampus possessing the capacity of differentiate into neurons and astrocytes both in vitro and vivo. Here, we investigated the capability of neural stem cell transplantation in photothrombosis stroke model. Nissl staining revealed that the cortical infarct significantly decreased by 16.32% (Vehicle: 27.93le: an mm3, n=6, NSC: 23.37le: ai mm3, n=6, P

  16. Linear Quadratic Gaussian Controller Design Using Loop Transfer Recovery for a Flexible Missile Model

    Science.gov (United States)

    1993-12-01

    Feedback Control System with Feedback Perturbation and Loop Broken at the Uncertainty ..................................... 42 Figure 19. General A-P...the observability matrix is given by 23 ’g = [C T ATC T A 2CT. .ATWICT] (38) The optimal output feedback control system is represented below. This...State Space Model of the Optimal Output Feedback Control System . The acceleration time response of the closed-loop system to a unit step acceleration

  17. Limitations on the recovery of the true AGN variability parameters using Damped Random Walk modeling

    CERN Document Server

    Kozłowski, Szymon

    2016-01-01

    Context: The damped random walk (DRW) stochastic process is nowadays frequently used to model aperiodic light curves of AGNs. A number of correlations between the DRW model parameters, the signal decorrelation timescale and amplitude, and the physical AGN parameters such as the black hole mass or luminosity have been reported. Aims: We are interested in whether it is plausible to correctly measure the DRW parameters from a typical ground-based survey, in particular how accurate the recovered DRW parameters are compared to the input ones. Methods: By means of Monte Carlo simulations of AGN light curves, we study the impact of the light curve length, the source magnitude, cadence, and additional light on the DRW model parameters. Results: The most significant finding is that currently existing surveys are going to return unconstrained DRW decorrelation timescales, because typical rest-frame data do not probe long enough timescales or the white noise part of PSD for DRW. The experiment length must be at least te...

  18. Forward and inverse problems of electrocardiography: modeling and recovery of epicardial potentials in humans.

    Science.gov (United States)

    Shahidi, A V; Savard, P; Nadeau, R

    1994-03-01

    To assess the accuracy of solutions to the inverse problem of electrocardiography in man, epicardial potentials computed from thoracic potential distributions were compared to potentials measured directly over the surface of the heart during arrhythmia surgery. Three-dimensional finite element models of the thorax with different mesh resolutions and conductivity inhomogeneities were constructed from serial computerized tomography scans of a patient. These torso models were used to compute transfer matrices relating the epicardial potentials to the thoracic potentials. Potential distributions over the torso and the ventricles were measured with 63 leads in the same patient whose anatomical data was used to construct the torso models. To solve the inverse problem, different methods based on Tykhonov regularization or regularization- truncation were applied. The recovered epicardial potential distributions closely resembled the epicardial potential distributions measured early during ventricular preexcitation, but not the more complex distributions measured later during the QRS complex. Several problems encountered as the validation process is applied in man are also discussed.

  19. Market disruption, cascading effects, and economic recovery:a life-cycle hypothesis model.

    Energy Technology Data Exchange (ETDEWEB)

    Sprigg, James A.

    2004-11-01

    This paper builds upon previous work [Sprigg and Ehlen, 2004] by introducing a bond market into a model of production and employment. The previous paper described an economy in which households choose whether to enter the labor and product markets based on wages and prices. Firms experiment with prices and employment levels to maximize their profits. We developed agent-based simulations using Aspen, a powerful economic modeling tool developed at Sandia, to demonstrate that multiple-firm economies converge toward the competitive equilibria typified by lower prices and higher output and employment, but also suffer from market noise stemming from consumer churn. In this paper we introduce a bond market as a mechanism for household savings. We simulate an economy of continuous overlapping generations in which each household grows older in the course of the simulation and continually revises its target level of savings according to a life-cycle hypothesis. Households can seek employment, earn income, purchase goods, and contribute to savings until they reach the mandatory retirement age; upon retirement households must draw from savings in order to purchase goods. This paper demonstrates the simultaneous convergence of product, labor, and savings markets to their calculated equilibria, and simulates how a disruption to a productive sector will create cascading effects in all markets. Subsequent work will use similar models to simulate how disruptions, such as terrorist attacks, would interplay with consumer confidence to affect financial markets and the broader economy.

  20. Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model.

    Science.gov (United States)

    Ma, Junning; Gao, Junwei; Hou, Boru; Liu, Jixing; Chen, Sihua; Yan, Guizhong; Ren, Haijun

    2015-01-01

    Stem cell-based therapy provides a promising approach for treat stroke. Neural stem cells isolated from mice hippocampus possessing the capacity of differentiate into neurons and astrocytes both in vitro and vivo. Here, we investigated the capability of neural stem cell transplantation in photothrombosis stroke model. Nissl staining revealed that the cortical infarct significantly decreased by 16.32% (Vehicle: 27.93le: an mm(3), n=6, NSC: 23.37le: ai mm(3), n=6, Pstem cells significantly (Pstem cell is an effective therapy in ischemic stroke.

  1. Supercritical CO2 recovery of caffeine from green coffee oil: new experimental solubility data and modeling

    OpenAIRE

    Azevedo, Álvaro Bandeira Antunes de; Kieckbusch,Theo Guenter; Tashima,Alexandre Keiji; Mohamed,Rahoma Sadeg; Mazzafera,Paulo; Melo, Silvio Alexandre Beisl Vieira de

    2008-01-01

    p. 1319-1323. The caffeine solubility in supercritical CO2 was studied by assessing the effects of pressure and temperature on the extraction of green coffee oil (GCO). The Peng-Robinson1 equation of state was used to correlate the solubility of caffeine with a thermodynamic model and two mixing rules were evaluated: the classical mixing rule of van der Waals with two adjustable parameters (PR-VDW) and a density dependent one, proposed by Mohamed and Holder2 with two (PR-MH, two parameters...

  2. Limitations on the recovery of the true AGN variability parameters using damped random walk modeling

    Science.gov (United States)

    Kozłowski, Szymon

    2017-01-01

    Context. The damped random walk (DRW) stochastic process is nowadays frequently used to model aperiodic light curves of active galactic nuclei (AGNs). A number of correlations between the DRW model parameters, the signal decorrelation timescale and amplitude, and the physical AGN parameters, such as the black hole mass or luminosity, have been reported. Aims: We are interested in whether or not it is plausible to correctly measure the DRW parameters from a typical ground-based survey, and, in particular, in how accurate the recovered DRW parameters are compared to the input ones. Methods: By means of Monte Carlo simulations of AGN light curves, we studied the impact of the light curve length, the source magnitude (the photometric properties of a survey), cadence, and additional light (e.g., from a host galaxy) on the DRW model parameters. Results: The most significant finding is that currently existing surveys are going to return unconstrained DRW decorrelation timescales, because typical rest-frame data do not probe long enough timescales or the white noise part of the power spectral density for DRW. The experiment length must be at least ten times longer than the true DRW decorrelation timescale, being presumably in the vicinity of one year, thus meaning the necessity for AGN light curves measuring a minimum of 10 years (rest-frame). The DRW timescales for sufficiently long light curves are typically weakly biased, and the exact bias depends on the fitting method and used priors. The DRW amplitude is mostly affected by the photometric noise (the source magnitude or the signal-to-noise ratio), cadence, and the AGN host light. Conclusions: Because the DRW parameters appear to be incorrectly determined from typically existing data, the reported correlations of the DRW variability and physical AGN parameters from other works seem unlikely to be correct. In particular, the anti-correlation of the DRW decorrelation timescale with redshift is a manifestation of the

  3. RECOVERY, A Mathematical Model to Predict the Temporal Response of Surface Water to Contaminated Sediments.

    Science.gov (United States)

    1994-11-01

    NewEngl d U.S. Art RAYo WAERAYaEPRIENCSATO Incudebilio grapicr•efe "M ( p prgam) 3dCOeTt L -E nv i Eroa BORpR of E. Nw Y ri.ARm E er Wter...constant = 8.206 x 10.5 atm m3/(gmole-kelvins) T = absolute temperature, kelvins. A temperature of 298K (25 °C) is assumed in the model. The parameter...bottom sediment material are shown in Table 3. Table 2 Concentrations of DDE and Lindane In Water Column Sampling Day DDE, ppt, X ± SD Undane, ppt, X

  4. Recovery Act: Web-based CO{sub 2} Subsurface Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Paolini, Christopher; Castillo, Jose

    2012-11-30

    The Web-based CO{sub 2} Subsurface Modeling project focused primarily on extending an existing text-only, command-line driven, isothermal and isobaric, geochemical reaction-transport simulation code, developed and donated by Sienna Geodynamics, into an easier-to-use Web-based application for simulating long-term storage of CO{sub 2} in geologic reservoirs. The Web-based interface developed through this project, publically accessible via URL http://symc.sdsu.edu/, enables rapid prototyping of CO{sub 2} injection scenarios and allows students without advanced knowledge of geochemistry to setup a typical sequestration scenario, invoke a simulation, analyze results, and then vary one or more problem parameters and quickly re-run a simulation to answer what-if questions. symc.sdsu.edu has 2x12 core AMD Opteron™ 6174 2.20GHz processors and 16GB RAM. The Web-based application was used to develop a new computational science course at San Diego State University, COMP 670: Numerical Simulation of CO{sub 2} Sequestration, which was taught during the fall semester of 2012. The purpose of the class was to introduce graduate students to Carbon Capture, Use and Storage (CCUS) through numerical modeling and simulation, and to teach students how to interpret simulation results to make predictions about long-term CO{sub 2} storage capacity in deep brine reservoirs. In addition to the training and education component of the project, significant software development efforts took place. Two computational science doctoral and one geological science masters student, under the direction of the PIs, extended the original code developed by Sienna Geodynamics, named Sym.8. New capabilities were added to Sym.8 to simulate non-isothermal and non-isobaric flows of charged aqueous solutes in porous media, in addition to incorporating HPC support into the code for execution on many-core XSEDE clusters. A successful outcome of this project was the funding and training of three new computational

  5. Disaster Debris Recovery Database - Recovery

    Data.gov (United States)

    U.S. Environmental Protection Agency — The US EPA Region 5 Disaster Debris Recovery Database includes public datasets of over 6,000 composting facilities, demolition contractors, transfer stations,...

  6. Pro-anorexia, weight-loss drugs and the internet: an "anti-recovery" explanatory model of anorexia.

    Science.gov (United States)

    Fox, Nick; Ward, Katie; O'Rourke, Alan

    2005-11-01

    This paper explores the online "pro-anorexia" underground, a movement that supports those with anorexia and adopts an "anti-recovery" perspective on the disease. While encouraging a "healthy" diet to sustain an anorexic way-of-life, the movement also recommends the radical use of weight-loss pharmaceuticals to pursue and maintain low body weight, in contrast to their conventional use to treat obesity. Using ethnographic and interview data collected from participants in the "Anagrrl" website and online forum, we analyse the pro-anorexia (or "pro-ana") movement in terms of its underlying "explanatory model" of the disease, and contrast it with medical, psychosocial, sociocultural and feminist models that encourage a "normalisation" of body shape and weight. We suggest that for participants in pro-ana, anorexia represents stability and control, and Anagrrl offers support and guidance for those who wish to remain in this "sanctuary". We discuss the pro-anorexia movement's use of the internet to facilitate resistance to medical and social theories of disease, and its subversion of pharmaceutical technologies.

  7. Bee Venom Acupuncture Reduces Interleukin-6, Increases Interleukin-10, and Induces Locomotor Recovery in a Model of Spinal Cord Compression.

    Science.gov (United States)

    Nascimento de Souza, Raquel; Silva, Fernanda Kohn; Alves de Medeiros, Magda

    2017-06-01

    Spinal cord injuries (SCIs) initiate a series of molecular and cellular events in which inflammatory responses can lead to major neurological dysfunctions. The present study aims to investigate whether bee venom (BV) acupuncture applied at acupoints ST36 (Zusanli) and GV3 (Yaoyangquan) could minimize locomotor deficits and the magnitude of neural tissue losses, and change the balance between pro- and anti-inflammatory cytokines after an SCI by compression. Wistar rats were subjected to an SCI model by compression in which a 2-French Fogarty embolectomy catheter was inflated in the extradural space. The effects of BV acupuncture, in which 20 μL of BV diluted in saline (0.08 mg/kg) was injected at acupoints GV3 and ST36 [BV(ST36+GV3)-SCI] was compared with BV injected at nonacupoints [BV(NP)-SCI] and with no treatment [group subjected only to SCI (CTL-SCI)]. The BV(ST36+GV3)-SCI group showed a significant improvement in the locomotor performance and a decrease of lesion size compared with the controls. BV acupuncture at the ST36 + GV3 increased the expression of interleukin-10 (anti-inflammatory) at 6 hours and reduced the expression of interleukin-6 (proinflammatory) at 24 hours after SCI compared with the controls. Our results suggest that BV acupuncture can reduce neuroinflammation and induce recovery in the SCI compression model. Copyright © 2017. Published by Elsevier B.V.

  8. CRYPTOGRAPHIC SECURE CLOUD STORAGE MODEL WITH ANONYMOUS AUTHENTICATION AND AUTOMATIC FILE RECOVERY

    Directory of Open Access Journals (Sweden)

    Sowmiya Murthy

    2014-10-01

    Full Text Available We propose a secure cloud storage model that addresses security and storage issues for cloud computing environments. Security is achieved by anonymous authentication which ensures that cloud users remain anonymous while getting duly authenticated. For achieving this goal, we propose a digital signature based authentication scheme with a decentralized architecture for distributed key management with multiple Key Distribution Centers. Homomorphic encryption scheme using Paillier public key cryptosystem is used for encrypting the data that is stored in the cloud. We incorporate a query driven approach for validating the access policies defined by an individual user for his/her data i.e. the access is granted to a requester only if his credentials matches with the hidden access policy. Further, since data is vulnerable to losses or damages due to the vagaries of the network, we propose an automatic retrieval mechanism where lost data is recovered by data replication and file replacement with string matching algorithm. We describe a prototype implementation of our proposed model.

  9. Combining BMI stimulation and mathematical modeling for acute stroke recovery and neural repair

    Directory of Open Access Journals (Sweden)

    Sara L Gonzalez Andino

    2011-07-01

    Full Text Available Rehabilitation is a neural plasticity-exploiting approach that forces undamaged neural circuits to undertake the functionality of other circuits damaged by stroke. It aims to partial restoration of the neural functions by circuit remodeling rather than by the regeneration of damaged circuits. The core hypothesis of the present paper is that - in stroke - Brain Machine Interfaces can be designed to target neural repair instead of rehabilitation. To support this hypothesis we first review existing evidence on the role of endogenous or externally applied electric fields on all processes involved in CNS repair. We then describe our own results to illustrate the neuroprotective and neuroregenerative effects of BMI- electrical stimulation on sensory deprivation-related degenerative processes of the CNS. Finally, we discuss three of the crucial issues involved in the design of neural repair-oriented BMIs: when to stimulate, where to stimulate and - the particularly important but unsolved issue of - how to stimulate. We argue that optimal parameters for the electrical stimulation can be determined from studying and modeling the dynamics of the electric fields that naturally emerge at the central and peripheral nervous system during spontaneous healing in both, experimental animals and human patients. We conclude that a closed-loop BMI that defines the optimal stimulation parameters from a priori developed experimental models of the dynamics of spontaneous repair and the on-line monitoring of neural activity might place BMIs as an alternative or complement to stem-cell transplantation or pharmacological approaches, intensively pursued nowadays.

  10. Energy performance modelling and heat recovery unit efficiency assessment of an office building

    Directory of Open Access Journals (Sweden)

    Harmati Norbert L.

    2015-01-01

    Full Text Available This paper investigates and analyzes a typical multi-zone office building’s annual energy performance for the location and climate data of central Belgrade. The aim is to evaluate the HVAC system’s and HR unit’s performance in order to conduct the most preferable heating and cooling solution for the typical climate of Belgrade city. The energy performance of four HVAC system types (heat pump - air to air, gas-electricity, electrical and fan coil system was analyzed, compared and evaluated on a virtual office building model in order to assess the total annual energy performance and to determine the efficiency of the HR unit’s application. Further, the parameters of an energy efficient building envelope, HVAC system, internal loads, building operation schedules and occupancy intervals were implemented into the multi-zone analysis model. The investigation was conducted in EnergyPlus simulation engine using system thermodynamic algorithms and surface/air heat balance modules. The comparison and evaluation of the obtained results was achieved through the conversion of the calculated total energy demand into primary energy. The goal is conduct the most preferable heating and cooling solution (Best Case Scenario for the climate of Belgrade city and outline major criteria in qualitative enhancement.

  11. Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model.

    Directory of Open Access Journals (Sweden)

    Johnatan Ceccom

    Full Text Available Alzheimer's disease (AD is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of copper circulation and homeostasis within the brain. Copper-containing amyloids activated by endogenous reductants are able to generate an oxidative stress that is involved in the toxicity of abnormal amyloids and contribute to the progressive loss of neurons in AD. Since only few drugs are currently available for the treatment of AD, we decided to design small molecules able to interact with copper and we evaluated these drug-candidates with non-transgenic mice, since AD is mainly an aging disease, not related to genetic disorders. We created a memory deficit mouse model by a single icv injection of Aβ(1-42 peptide, in order to mimic the early stage of the disease and the key role of amyloid oligomers in AD. No memory deficit was observed in the control mice with the antisense Aβ(42-1 peptide. Here we report the capacity of a new copper-specific chelating agent, a bis-8-aminoquinoline PA1637, to fully reverse the deficit of episodic memory after three weeks of treatment by oral route on non-transgenic amyloid-impaired mice. Clioquinol and memantine have been used as comparators to validate this fast and efficient mouse model.

  12. Recovery concept in a Norwegian setting to be examined by the assertive community treatment model and mixed methods.

    Science.gov (United States)

    Lofthus, Ann-Mari; Westerlund, Heidi; Bjørgen, Dagfinn; Lindstrøm, Jonas Christoffer; Lauveng, Arnhild; Rose, Diana; Ruud, Torleif; Heiervang, Kristin

    2016-12-27

    Recovery is a crucial concept in the mental health field. The research of recovery is split into the categories of personal, social and clinical recovery. The purpose of this study was to explore the fragmented concept of recovery in light of assertive community treatment (ACT) in Norway. The study has a mixed methods design with a pragmatic approach. The Questionnaire about the Process of Recovery and open-ended questions posed to 70 participants from 12 ACT teams in Norway, gathered by the "Users interview users" method, are combined with interviews or focus groups with eight of these participants. Surprisingly those under a community treatment order (CTO) report the highest degree of personal recovery. The qualitative material shows that the service users interpreted the concept of recovery differently than researchers and professionals. The ACT service users highlighted three important elements: flexible treatment, medication and access to a car. They emphasized the necessity for basic needs to be met in order to experience a meaningful recovery process, and these basic needs may be of even greater importance to those under CTOs. Their experiences should imply a greater emphasis on securing basic needs such as secure housing, sounder finances and access to the normal benefits offered by society. © 2016 Australian College of Mental Health Nurses Inc.

  13. Ecological recovery in ERA

    DEFF Research Database (Denmark)

    EFSA Scientific Committee (Scientific Committee); Topping, Christopher John

    2016-01-01

    recognises the importance of more integrated ERAs considering both the local and landscape scales, as well as the possible co-occurrence of multiple potential stressors that fall under the remit of EFSA, which are important when addressing ecological recovery. In this scientific opinion, the Scientific...... ecological recovery for any assessed products, and invasive alien species that are harmful for plant health. This framework proposes an integrative approach based on well-defined specific protection goals, scientific knowledge derived by means of experimentation, modelling and monitoring, and the selection...... Committee gathered scientific knowledge on the potential for the recovery of non-target organisms for the further development of ERA. Current EFSA guidance documents and opinions were reviewed on how ecological recovery is addressed in ERA schemes. In addition, this scientific opinion is based on expert...

  14. Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.

    Science.gov (United States)

    Spiller, Krista J; Cheung, Claudia J; Restrepo, Clark R; Kwong, Linda K; Stieber, Anna M; Trojanowski, John Q; Lee, Virginia M-Y

    2016-07-20

    Motor neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (ALS), but it is widely known that individual motor pools do not succumb to degeneration simultaneously. Because >90% of ALS patients have an accumulation of cytoplasmic TDP-43 aggregates in postmortem brain and spinal cord (SC), it has been suggested that these inclusions in a given population may trigger its death. We investigated seven MN pools in our new inducible rNLS8 transgenic (Tg) mouse model of TDP-43 proteinopathy and found striking differences in MN responses to TDP-43 pathology. Despite widespread neuronal expression of cytoplasmic human TDP-43, only MNs in the hypoglossal nucleus and the SC are lost after 8 weeks of transgene expression, whereas those in the oculomotor, trigeminal, and facial nuclei are spared. Within the SC, slow MNs survive to end stage, whereas fast fatigable MNs are lost. Correspondingly, axonal dieback occurs first from fast-twitch muscle fibers, whereas slow-twitch fibers remain innervated. Individual pools show differences in the downregulation of endogenous nuclear TDP-43, but this does not fully account for vulnerability to degenerate. After transgene suppression, resistant MNs sprout collaterals to reinnervate previously denervated neuromuscular junctions concurrently with expression of matrix metalloproteinase 9 (MMP-9), a marker of fast MNs. Therefore, although pathological TDP-43 is linked to MN degeneration, the process is not stochastic and mirrors the highly selective patterns of MN degeneration observed in ALS patients. Because TDP-43 is the major pathological hallmark of amyotrophic lateral sclerosis (ALS), we generated mice in which mutant human TDP-43 expression causes progressive neuron loss. We show that these rNLS8 mice have a pattern of axonal dieback and cell death that mirrors that often observed in human patients. This finding demonstrates the diversity of motor neuron (MN) populations in their response

  15. Non-linear model predictive supervisory controller for building, air handling unit with recuperator and refrigeration system with heat waste recovery

    DEFF Research Database (Denmark)

    Minko, Tomasz; Wisniewski, Rafal; Bendtsen, Jan Dimon

    2016-01-01

    In this paper we examine a supermarket system. In order to grasp the most important dynamics we present a model that includes the single zone building thermal envelope with its heating, cooling and ventilation. Moreover we include heat waste recovery from the refrigeration high pressure side. The...

  16. Recovery of Item Parameters in the Nominal Response Model: A Comparison of Marginal Maximum Likelihood Estimation and Markov Chain Monte Carlo Estimation.

    Science.gov (United States)

    Wollack, James A.; Bolt, Daniel M.; Cohen, Allan S.; Lee, Young-Sun

    2002-01-01

    Compared the quality of item parameter estimates for marginal maximum likelihood (MML) and Markov Chain Monte Carlo (MCMC) with the nominal response model using simulation. The quality of item parameter recovery was nearly identical for MML and MCMC, and both methods tended to produce good estimates. (SLD)

  17. 3-D Reservoir and Stochastic Fracture Network Modeling for Enhanced Oil Recovery, Circle Ridge Phosphoria/Tensleep Reservoir, and River Reservation, Arapaho and Shoshone Tribes, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    La Pointe, Paul R.; Hermanson, Jan

    2002-09-09

    The goal of this project is to improve the recovery of oil from the Circle Ridge Oilfield, located on the Wind River Reservation in Wyoming, through an innovative integration of matrix characterization, structural reconstruction, and the characterization of the fracturing in the reservoir through the use of discrete fracture network models.

  18. Supercritical CO2 recovery of caffeine from green coffee oil: new experimental solubility data and modeling

    Directory of Open Access Journals (Sweden)

    Álvaro Bandeira Antunes de Azevedo

    2008-01-01

    Full Text Available The caffeine solubility in supercritical CO2 was studied by assessing the effects of pressure and temperature on the extraction of green coffee oil (GCO. The Peng-Robinson¹ equation of state was used to correlate the solubility of caffeine with a thermodynamic model and two mixing rules were evaluated: the classical mixing rule of van der Waals with two adjustable parameters (PR-VDW and a density dependent one, proposed by Mohamed and Holder² with two (PR-MH, two parameters adjusted to the attractive term and three (PR-MH3 two parameters adjusted to the attractive and one to the repulsive term adjustable parameters. The best results were obtained with the mixing rule of Mohamed and Holder² with three parameters.

  19. Microemulsions as model fluids for enhanced oil recovery: dynamics adjacent to planar hydrophilic walls

    Directory of Open Access Journals (Sweden)

    Mattauch S.

    2012-10-01

    Full Text Available After the dynamics of microemulsions adjacent to a planar hydrophilic wall have been characterized using grazing incidence neutron spin echo spectroscopy, the model of Seifert was employed to explain the discovered acceleration for the surface near lamellar ordered membranes. Reflections of hydrodynamic waves by the wall – or the volume conservation between the membrane and the wall – explain faster relaxations and, therefore, a lubrication effect that is important for flow fields in narrow pores. The whole scenery is now spectated by using different scenarios of a bicontinuous microemulsion exposed to clay particles and of a lamellar microemulsion adjacent to a planar wall. The Seifert concept could successfully be transferred to the new problems.

  20. MODELING AND SIMULATION OF A BENZENE RECOVERY PROCESS BY EXTRACTIVE DISTILLATION

    Directory of Open Access Journals (Sweden)

    L. B. Brondani

    2015-03-01

    Full Text Available Abstract Extractive distillation processes with N-formylmorpholine (NFM are used industrially to separate benzene from six carbon non-aromatics. In the process studied in this work, the stream of interest consists of nearly 20 different hydrocarbons. A new set of NRTL parameters was correlated based on literature experimental data. Both vapor-liquid equilibrium as well as infinite dilution activity coefficient data were taken into account; missing parameters were estimated with the UNIFAC group contribution model. The extractive distillation process was simulated using ASPEN Plus®. Very good agreement with plant data was obtained. The influences of the main operational parameters, solvent to feed ratio and solvent temperature, were studied. Theoretical optimum operating values were obtained and can be implemented to improve the industrial process. Extreme static sensitivity with respect to reboiler heat was observed, indicating that this can be the source of instabilities.

  1. Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences.

    Directory of Open Access Journals (Sweden)

    Sara Zgheib

    Full Text Available BACKGROUND: Anorexia nervosa is a primary psychiatric disorder, with non-negligible rates of mortality and morbidity. Some of the related alterations could participate in a vicious cycle limiting the recovery. Animal models mimicking various physiological alterations related to anorexia nervosa are necessary to provide better strategies of treatment. AIM: To explore physiological alterations and recovery in a long-term mouse model mimicking numerous consequences of severe anorexia nervosa. METHODS: C57Bl/6 female mice were submitted to a separation-based anorexia protocol combining separation and time-restricted feeding for 10 weeks. Thereafter, mice were housed in standard conditions for 10 weeks. Body weight, food intake, body composition, plasma levels of leptin, adiponectin, IGF-1, blood levels of GH, reproductive function and glucose tolerance were followed. Gene expression of several markers of lipid and energy metabolism was assayed in adipose tissues. RESULTS: Mimicking what is observed in anorexia nervosa patients, and despite a food intake close to that of control mice, separation-based anorexia mice displayed marked alterations in body weight, fat mass, lean mass, bone mass acquisition, reproductive function, GH/IGF-1 axis, and leptinemia. mRNA levels of markers of lipogenesis, lipolysis, and the brown-like adipocyte lineage in subcutaneous adipose tissue were also changed. All these alterations were corrected during the recovery phase, except for the hypoleptinemia that persisted despite the full recovery of fat mass. CONCLUSION: This study strongly supports the separation-based anorexia protocol as a valuable model of long-term negative energy balance state that closely mimics various symptoms observed in anorexia nervosa, including metabolic adaptations. Interestingly, during a recovery phase, mice showed a high capacity to normalize these parameters with the exception of plasma leptin levels. It will be interesting therefore to

  2. Kinetic Modelling for Flavonoid Recovery from Red Grape (Vitis vinifera Pomace with Aqueous Lactic Acid

    Directory of Open Access Journals (Sweden)

    Katerina Tzima

    2014-12-01

    Full Text Available This study was undertaken with the aim of establishing a correlation between the extraction yield in total flavonoids from red grape pomace and the extraction temperature, using 0.5% (w/v aqueous lactic acid as the solvent system. Extraction of flavonoids was found to obey second-order kinetics, and on such a basis, the yield in total flavonoids at saturation could be very effectively determined and correlated with temperature using non-linear regression. The results indicated that the extraction yield at saturation is highly correlated with temperature, following a quadratic function. The extract obtained at 40 °C had an optimal predicted total flavonoid yield of 13.27 mg rutin equivalents per gram of dry weight, and it was further analyzed by liquid chromatography-mass spectrometry to characterize its major constituents. The polyphenols detected were flavanols, flavonols and an anthocyanin. The outcome of this study outlined that temperatures above 40 °C are rather unfavorable for flavonoid extraction from red grape pomace, as suggested by the model established through kinetics.

  3. Functional recovery after experimental RPE debridement, mfERG studies in a porcine model.

    Science.gov (United States)

    Sørensen, Nina Buus; Lassota, Nathan; Kyhn, Maria Voss; Prause, Jan Ulrik; Qvortrup, Klaus; la Cour, Morten; Kiilgaard, Jens

    2013-10-01

    The correlation between histologically identified regeneration of retinal pigment epithelium (RPE) and functional outcome measured by multifocal electroretinography (mfERG) following surgical debridement is examined in a porcine model. In humans, visual acuity is reduced in diseases with RPE loss such as RPE tears and geographic atrophy. Hypopigmented RPE is known to cover the lesion after RPE debridement in the pig, but it is unclear whether this leads to a return of photoreceptor function. RPE debridement was performed in ten pigs by vitrectomy and retinotomy, and by brushing the Bruch's membrane with a silicone catheter. Immediately following surgery (baseline) and after 2 and 6 weeks respectively, the animals were examined by mfERG, fundus photographs (FPs), fluorescein angiograms (FAs), and histopathology. The mfERG P1 amplitude was decreased 2 weeks (T₂) after surgery; it returned to baseline 6 weeks (T₆) after surgery. FPs, FAs, and histology showed partial repopulation of Bruch's membrane by hypopigmented RPE cells and atrophied outer segments at T₂. At T₆, normally pigmented RPE cells were identified, and the photoreceptor layer was restored. This is the first study to show that the histological regeneration of hypopigmented RPE correlates to a return of the retinal function, measured by mfERG.

  4. Modelling how incorporation of divalent cations affects calcite wettability–implications for biomineralisation and oil recovery

    Science.gov (United States)

    Andersson, M. P.; Dideriksen, K.; Sakuma, H.; Stipp, S. L. S.

    2016-06-01

    Using density functional theory and geochemical speciation modelling, we predicted how solid-fluid interfacial energy is changed, when divalent cations substitute into a calcite surface. The effect on wettability can be dramatic. Trace metal uptake can impact organic compound adsorption, with effects for example, on the ability of organisms to control crystal growth and our ability to predict the wettability of pore surfaces. Wettability influences how easily an organic phase can be removed from a surface, either organic compounds from contaminated soil or crude oil from a reservoir. In our simulations, transition metals substituted exothermically into calcite and more favourably into sites at the surface than in the bulk, meaning that surface properties are more strongly affected than results from bulk experiments imply. As a result of divalent cation substitution, calcite-fluid interfacial energy is significantly altered, enough to change macroscopic contact angle by tens of degrees. Substitution of Sr, Ba and Pb makes surfaces more hydrophobic. With substitution of Mg and the transition metals, calcite becomes more hydrophilic, weakening organic compound adsorption. For biomineralisation, this provides a switch for turning on and off the activity of organic crystal growth inhibitors, thereby controlling the shape of the associated mineral phase.

  5. Costs and Benefits in the Recovery of Historic Buildings: The Application of an Economic Model

    Directory of Open Access Journals (Sweden)

    Antonio Nesticò

    2015-11-01

    Full Text Available Until now, the policies on sustainability relating to regeneration interventions on historic buildings have dealt with the casing of the buildings in order to regulate and control the flow of air, light and energy from outside to inside and vice versa. However, recent technological developments in home comfort and energy savings highlight the efficiency of the plants and the proper management of the building-plant system, while respecting the criteria of integrated conservation and the multiple constraints that characterize historic buildings. This study proposes a methodological process that identifies the optimal steps from a technical and economical point of view, by providing a combination of traditional architectural conservation interventions with innovative technology systems. The calculation algorithms are developed with a specific software based on UNI TS 11300 regulations, which allows for the thermodynamic modelling of the structure. The preparation of the feasibility plan allows testing the cost-effectiveness of the work proposed, considering the environmental benefits resulting from the reduced CO2 emissions. The impact of the financial results of the evaluation is also analyzed. This protocol provides industry operators a useful instrument for selecting the least expensive initiatives among those compatible with the multiple constraints that affect the design choices.

  6. Recovery Spirituality

    Directory of Open Access Journals (Sweden)

    Ernest Kurtz

    2015-01-01

    Full Text Available There is growing interest in Alcoholics Anonymous (A.A. and other secular, spiritual, and religious frameworks of long-term addiction recovery. The present paper explores the varieties of spiritual experience within A.A., with particular reference to the growth of a wing of recovery spirituality promoted within A.A. It is suggested that the essence of secular spirituality is reflected in the experience of beyond (horizontal and vertical transcendence and between (connection and mutuality and in six facets of spirituality (Release, Gratitude, Humility, Tolerance, Forgiveness, and a Sense of Being-at-home shared across religious, spiritual, and secular pathways of addiction recovery. The growing varieties of A.A. spirituality (spanning the “Christianizers” and “Seculizers” reflect A.A.’s adaptation to the larger diversification of religious experience and the growing secularization of spirituality across the cultural contexts within which A.A. is nested.

  7. Modelling the effect of exposing algae to pulses of S-metolachlor: How to include a delay to the onset of the effect and in the recovery.

    Science.gov (United States)

    Copin, Pierre-Jean; Perronet, Léa; Chèvre, Nathalie

    2016-01-15

    In agriculture, herbicides are applied to improve crop productivity. During and after rain event, herbicides can be transported by surface runoff in streams and rivers. As a result, the exposure pattern in creeks is time-varying, i.e., a repeated pollution of aquatic system. In previous studies, we developed a model to assess the effects of pulse exposure patterns on algae. This model was validated for triazines and phenylureas, which are substances that induce effects directly after exposure with no delay in recovery. However, other herbicides display a mode of action characterized by a time-dependency effect and a delay in recovery. In this study, we therefore investigate whether this previous model could be used to assess the effects of pulse exposure by herbicides with time delay in effect and recovery. The current study focuses on the herbicide S-metolachlor. We showed that the effect of the herbicide begins only after 20 h of exposure for the alga Scenedesmus vacuolatus based on both the optical density and algal cells size measurements. Furthermore, the duration of delay of the recovery for algae previously exposed to S-metolachlor was 20 h and did not depend on the pulse exposure duration or the height of the peak concentration. By accounting for these specific effects, the measured and predicted effects were similar when pulse exposure of S-metolachlor is tested on the alga S. vacuolatus. However, the sensitivity of the alga is greatly modified after being previously exposed to a pulse of S-metolachlor. In the case of scenarios composed of several pulses, this sensitivity should be considered in the modelling. Therefore, modelling the effects of any pulse scenario of S-metolachlor on an alga is feasible but requires the determination of the effect trigger, the delay in recovery and the possible change in the sensitivity of the alga to the substance.

  8. Integrated Resource Management and Recovery

    DEFF Research Database (Denmark)

    Astrup, Thomas Fruergaard

    2014-01-01

    resources, i.e. security of supply, but also the need for efficient recovery of the same resources after the use-phase of the products. While this recovery may appear simple, considerable challenges exist. Management and recovery of resources in waste materials, or in general residual streams in society......, depends on the quality of these resources and technological abilities to extract resources from mixed materials, e.g. mobile phones, solar cells, or mixed domestic waste. The "effort" invested in recovery of secondary resources should not be more than the "benefit" associated with the secondary resources....... Over the recent decades, DTU Environment has worked extensively both with resource recovery technologies and life cycle assessment (LCA) models (www.EASETECH.dk) dedicated to evaluating resource management and recovery systems. Advanced sustainability assessments of resource recovery and utilization...

  9. Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.

    Directory of Open Access Journals (Sweden)

    Roni Scherzer-Attali

    Full Text Available The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies have demonstrated that quinones, specifically anthraquinones, can serve as aggregation inhibitors probably due to the dipole interaction of the quinonic ring with aromatic recognition sites within the amyloidogenic proteins. Here, using in vitro, in vivo and in silico tools we describe the synthesis and functional characterization of a rationally designed inhibitor of the Alzheimer's disease-associated beta-amyloid. This compound, 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp, combines the recognition capacities of both quinone and tryptophan moieties and completely inhibited Abeta oligomerization and fibrillization, as well as the cytotoxic effect of Abeta oligomers towards cultured neuronal cell line. Furthermore, when fed to transgenic Alzheimer's disease Drosophila model it prolonged their life span and completely abolished their defective locomotion. Analysis of the brains of these flies showed a significant reduction in oligomeric species of Abeta while immuno-staining of the 3(rd instar larval brains showed a significant reduction in Abeta accumulation. Computational studies, as well as NMR and CD spectroscopy provide mechanistic insight into the activity of the compound which is most likely mediated by clamping of the aromatic recognition interface in the central segment of Abeta. Our results demonstrate that interfering with the aromatic core of amyloidogenic peptides is a promising approach for inhibiting various pathogenic species associated with amyloidogenic diseases. The compound NQTrp can serve as a lead for developing a new class of disease modifying drugs for Alzheimer's disease.

  10. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model.

    Directory of Open Access Journals (Sweden)

    Zheng Ke

    Full Text Available BACKGROUND: Stroke rehabilitation with different exercise paradigms has been investigated, but which one is more effective in facilitating motor recovery and up-regulating brain neurotrophic factor (BDNF after brain ischemia would be interesting to clinicians and patients. Voluntary exercise, forced exercise, and involuntary muscle movement caused by functional electrical stimulation (FES have been individually demonstrated effective as stroke rehabilitation intervention. The aim of this study was to investigate the effects of these three common interventions on brain BDNF changes and motor recovery levels using a rat ischemic stroke model. METHODOLOGY/PRINCIPAL FINDINGS: One hundred and seventeen Sprague-Dawley rats were randomly distributed into four groups: Control (Con, Voluntary exercise of wheel running (V-Ex, Forced exercise of treadmill running (F-Ex, and Involuntary exercise of FES (I-Ex with implanted electrodes placed in two hind limb muscles on the affected side to mimic gait-like walking pattern during stimulation. Ischemic stroke was induced in all rats with the middle cerebral artery occlusion/reperfusion model and fifty-seven rats had motor deficits after stroke. Twenty-four hours after reperfusion, rats were arranged to their intervention programs. De Ryck's behavioral test was conducted daily during the 7-day intervention as an evaluation tool of motor recovery. Serum corticosterone concentration and BDNF levels in the hippocampus, striatum, and cortex were measured after the rats were sacrificed. V-Ex had significantly better motor recovery in the behavioral test. V-Ex also had significantly higher hippocampal BDNF concentration than F-Ex and Con. F-Ex had significantly higher serum corticosterone level than other groups. CONCLUSION/SIGNIFICANCE: Voluntary exercise is the most effective intervention in upregulating the hippocampal BDNF level, and facilitating motor recovery. Rats that exercised voluntarily also showed less

  11. Efficiency of Artemia cysts removal as a model invasive spore using a continuous microwave system with heat recovery.

    Science.gov (United States)

    Balasubramanian, Sundar; Ortego, Jeffrey; Rusch, Kelly A; Boldor, Dorin

    2008-12-15

    A continuous microwave system to treat ballast water inoculated with Artemia salina cysts as a model invasive spore was tested for its efficacy in inactivating the cysts present. The system was tested at two different flow rates (1 and 2 L x min(-1)) and two different power levels (2.5 and 4.5 kW). Temperature profiles indicate that the system could deliver heating loads in excess of 100 degrees C in a uniform and near-instantaneous manner when using a heat recovery system. Except for a power and flow rate combination of 2.5 kW and 2 L x min(-1), complete inactivation of the cysts was observed at all combinations at holding times below 100 s. The microwave treatment was better or equal to the control treatment in inactivating the cysts. Use of heat exchangers increased the power conversion efficiency and the overall efficiency of the treatment system. Cost economics analysis indicates that in the present form of development microwave treatment costs are higher than the existing ballast water treatment methods. Overall, tests results indicated that microwave treatment of ballast water is a promising method that can be used in conjunction with other methods to form an efficient treatment system that can prevent introduction of potentially invasive spore forming species in non-native waters.

  12. Uses and abuses of recovery: implementing recovery-oriented practices in mental health systems

    OpenAIRE

    Slade, Mike; Amering, M.; FARKAS, MARIANNE; Hamilton, Bridget; O'Hagan, Mary; Panther, Gavin; Perkins, Rachel; Shepherd, Geoff; Tse, Samson; Whitley, R.

    2014-01-01

    An understanding of recovery as a personal and subjective experience has emerged within mental health systems. This meaning of recovery now underpins mental health policy in many countries. Developing a focus on this type of recovery will involve transformation within mental health systems. Human systems do not easily transform. In this paper, we identify seven mis-uses (“abuses”) of the concept of recovery: recovery is the latest model; recovery does not apply to “my” patients; services can ...

  13. Spontaneous Recovery

    Science.gov (United States)

    Rescorla, Robert A.

    2004-01-01

    Spontaneous recovery from extinction is one of the most basic phenomena of Pavlovian conditioning. Although it can be studied by using a variety of designs, some procedures are better than others for identifying the involvement of underlying learning processes. A wide range of different learning mechanisms has been suggested as being engaged by…

  14. Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models.

    Science.gov (United States)

    Worni-Schudel, Inge M; Clark, Amy G; Chien, Tiffany; Hwang, Kwan-Ki; Chen, Benny J; Foster, Mary H

    2015-06-06

    Anti-glomerular basement membrane nephritis and Goodpasture syndrome result from autoantibody (Ab)-mediated destruction of kidney and lung. Ab target the noncollagenous 1 (NC1) domain of alpha3(IV) collagen, but little is known about Ab origins or structure. This ignorance is due in part to the inability to recover monoclonal Ab by transformation of patients' blood cells. The aim of this study was to assess the suitability of two humanized models for this purpose. NOD-scid-gamma immunodeficient mice were engrafted either with human CD34+ hematopoietic stem cells (HSC) (Hu-HSC mice) and immunized with alpha3(IV)NC1 collagen containing the Goodpasture epitopes or with nephritis patients' peripheral blood leukocytes (PBL) (Hu-PBL mice). After in vivo immune cell development and/or expansion, recovered human B cells were Epstein Barr virus (EBV)-transformed, screened for antigen (Ag) binding, electrofused with a mouse-human heterohybridoma, subcloned, and human Ab RNA sequenced by PCR after reverse transcription to cDNA. Flow cytometry was used to assess human B cell markers and differentiation in Hu-PBL mice. Sequence analysis of a human Ab derived from an immunized Hu-HSC mouse and reactive with alpha3(IV)NC1 collagen reveals that it is encoded by unmutated heavy and light chain genes. The heavy chain complementarity determining region 3, a major determinant of Ag binding, contains uncommon motifs, including an N-region somatically-introduced highly hydrophobic tetrapeptide and dual cysteines encoded by a uniquely human IGHD2-2 Ab gene segment that lacks a murine counterpart. Comparison of human and mouse autoantibodies suggests that structurally similar murine Ab may arise by convergent selection. In contrast to the Hu-HSC model, transformed human B cells are rarely recovered from Hu-PBL mice, in which human B cells terminally differentiate and lose expression of EBV receptor CD21, thus precluding their transformation and recovery. Hu-HSC mice reveal that

  15. Genetic parameters of different measures of cheese yield and milk nutrient recovery from an individual model cheese-manufacturing process.

    Science.gov (United States)

    Bittante, G; Cipolat-Gotet, C; Cecchinato, A

    2013-01-01

    Cheese yield (CY) is an important technological trait in the dairy industry, and the objective of this study was to estimate the genetic parameters of cheese yield in a dairy cattle population using an individual model-cheese production procedure. A total of 1,167 Brown Swiss cows belonging to 85 herds were sampled once (a maximum of 15 cows were sampled per herd on a single test day, 1 or 2 herds per week). From each cow, 1,500 mL of milk was processed according to the following steps: milk sampling and heating, culture addition, rennet addition, gelation-time recording, curd cutting, whey draining and sampling, wheel formation, pressing, salting in brine, weighing, and cheese sampling. The compositions of individual milk, whey, and curd samples were determined. Three measures of percentage cheese yield (%CY) were calculated: %CY(CURD), %CY(SOLIDS), and %CY(WATER), which represented the ratios between the weight of fresh curd, the total solids of the curd, and the water content of the curd, respectively, and the weight of the milk processed. In addition, 3 measures of daily cheese yield (dCY, kg/d) were defined, considering the daily milk yield. Three measures of nutrient recovery (REC) were computed: REC(FAT), REC(PROTEIN), and REC(SOLIDS), which represented the ratio between the weights of the fat, protein, and total solids in the curd, respectively, and the corresponding nutrient in the milk. Energy recovery, REC(ENERGY), represented the energy content of the cheese versus that in the milk. For statistical analysis, a Bayesian animal model was implemented via Gibbs sampling. The effects of parity (1 to ≥4), days in milk (6 classes), and laboratory vat (15 vats) were assigned flat priors; those of herd-test-date, animal, and residual were given Gaussian prior distributions. Intra-herd heritability estimates of %CY(CURD), %CY(SOLIDS), and %CY(WATER) ranged from 0.224 to 0.267; these were larger than the estimates obtained for milk yield (0.182) and milk fat

  16. Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis

    Institute of Scientific and Technical Information of China (English)

    Lianhua Bai; Jordan Hecker; Amber Kerstetter; Robert H.Miller

    2013-01-01

    Cellular therapies are becoming a major focus for the treatment of demyelinating diseases such as multiple sclerosis (MS),therefore it is important to identify the most effective cell types that promote myelin repair.Several components contribute to the relative benefits of specific cell types including the overall efficacy of the cell therapy,the reproducibility of treatment,the mechanisms of action of distinct cell types and the ease of isolation and generation of therapeutic populations.A range of distinct cell populations promote functional recovery in animal models of MS including neural stem cells and mesenchymal stem cells derived from different tissues.Each of these cell populations has advantages and disadvantages and likely works through distinct mechanisms.The relevance of such mechanisms to myelin repair in the adult central nervous system is unclear since the therapeutic cells are generally derived from developing animals.Here we describe the isolation and characterization of a population of neural cells from the adult spinal cord that are characterized by the expression of the cell surface glycoprotein NG2.In functional studies,injection of adult NG2+ cells into mice with ongoing MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) enhanced remyelination in the CNS while the number of CD3+ T cells in areas of spinal cord demyelination was reduced approximately three-fold.In vivo studies indicated that in EAE,NG2+ cells stimulated endogenous repair while in vitro they responded to signals in areas of induced inflammation by differentiating into oligodendrocytes.These results suggested that adult NG2+ cells represent a useful cell population for promoting neural repair in a variety of different conditions including demyelinating diseases such as MS.

  17. Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models.

    Science.gov (United States)

    Marinelli, S; Luvisetto, S; Cobianchi, S; Makuch, W; Obara, I; Mezzaroma, E; Caruso, M; Straface, E; Przewlocka, B; Pavone, F

    2010-11-24

    A growing interest was recently focused on the use of Botulinum neurotoxin serotype A (BoNT/A) for fighting pain. The aim of this study was to investigate the effects of BoNT/A on neuropathic pain. It was observed that BoNT/A is able to counteract neuropathic pain induced by chronic constriction injury (CCI) to the sciatic nerve both in mice and in rats. This effect is already present after a single intraplantar (i.pl.) or intrathecal (i.t.) neurotoxin administration that significantly reduces the sciatic nerve ligation-induced mechanical allodynia in mice and rats and thermal hyperalgesia in rats. This effect was evident starting 24 h after the administration of BoNT/A and it was long-lasting, being present 81 or 25 days after i.pl. injection of the higher dose in mice (15 pg/paw) and rats (75 pg/paw), respectively, and 35 days after i.t. injection in rats (75 pg/rat). Moreover, BoNT/A-injected mice showed a quicker recovery of the walking pattern and weight bearing compared to control groups. The behavioral improvement was accompanied by structural modifications, as revealed by the expression of cell division cycle 2 (Cdc2) and growth associated protein 43 (GAP-43) regeneration associated proteins, investigated by immunofluorescence and Western blotting in the sciatic nerve, and by the immunofluorescence expression of S100β and glial fibrillary acidic protein (GFAP) Schwann cells proteins. In conclusion, the present research demonstrate long-lasting anti-allodynic and anti-hyperalgesic effects of BoNT/A in animal models of neuropathic pain together with an acceleration of regenerative processes in the injured nerve, as evidenced by both behavioral and immunohistochemistry/blotting analysis. These results may have important implications in the therapy of neuropathic pain.

  18. Using expert knowledge and modeling to define mangrove composition, functioning, and threats and estimate time frame for recovery.

    Science.gov (United States)

    Mukherjee, Nibedita; Sutherland, William J; Khan, Md Nabiul I; Berger, Uta; Schmitz, Nele; Dahdouh-Guebas, Farid; Koedam, Nico

    2014-06-01

    Mangroves are threatened worldwide, and their loss or degradation could impact functioning of the ecosystem. Our aim was to investigate three aspects of mangroves at a global scale: (1) their constituents (2) their indispensable ecological functions, and (3) the maintenance of their constituents and functions in degraded mangroves. We focused on answering two questions: "What is a mangrove ecosystem" and "How vulnerable are mangrove ecosystems to different impacts"? We invited 106 mangrove experts globally to participate in a survey based on the Delphi technique and provide inputs on the three aspects. The outputs from the Delphi technique for the third aspect, i.e. maintenance of constituents and functions were incorporated in a modeling approach to simulate the time frame for recovery. Presented here for the first time are the consensus definition of the mangrove ecosystem and the list of mangrove plant species. In this study, experts considered even monospecific (tree) stands to be a mangrove ecosystem as long as there was adequate tidal exchange, propagule dispersal, and faunal interactions. We provide a ranking of the important ecological functions, faunal groups, and impacts on mangroves. Degradation due to development was identified as having the largest impact on mangroves globally in terms of spatial scale, intensity, and time needed for restoration. The results indicate that mangroves are ecologically unique even though they may be species poor (from the vegetation perspective). The consensus list of mangrove species and the ranking of the mangrove ecological functions could be a useful tool for restoration and management of mangroves. While there is ample literature on the destruction of mangroves due to aquaculture in the past decade, this study clearly shows that more attention must go to avoiding and mitigating mangrove loss due to coastal development (such as building of roads, ports, or harbors).

  19. Orimulsion containment and recovery

    Energy Technology Data Exchange (ETDEWEB)

    Sommerville, M. [Briggs Marine Environmental Services, Aberdeen (United Kingdom)

    1999-01-01

    This paper focuses on the need for examination of Orimulsion fuel and its spill behaviour in the light of the anticipated increase in consumption of this fuel which comprises bitumen dispersed in water with addition of a small amount of surfactant. The behaviour and fate of Orimulsion at sea, and observations from experimental and sea trials are examined. The identification of spill control techniques, spill detection, the predictive modeling of the spill and response, sub-surface plume measurement, and containment and deflection are considered. Recovery of the bitumen produced from an Orimulsion spill, combined containment and recovery, dispersed Orimulsion, and beach cleaning are addressed. The properties of Orimulsion are tabulated. (UK)

  20. Mechanism of functional recovery after repetitive transcranial magnetic stimulation (rTMS) in the subacute cerebral ischemic rat model: neural plasticity or anti-apoptosis?

    Science.gov (United States)

    Yoon, Kyung Jae; Lee, Yong-Taek; Han, Tai Ryoon

    2011-10-01

    Repetitive transcranial magnetic stimulation (rTMS) has been studied increasingly in recent years to determine whether it has a therapeutic benefit on recovery after stroke. However, the underlying mechanisms of rTMS in stroke recovery remain unclear. Here, we evaluated the effect of rTMS on functional recovery and its underlying mechanism by assessing proteins associated with neural plasticity and anti-apoptosis in the peri-lesional area using a subacute cerebral ischemic rat model. Twenty cerebral ischemic rats were randomly assigned to the rTMS or the sham group at post-op day 4. A total of 3,500 impulses with 10 Hz frequency were applied to ipsilesional cortex over a 2-week period. Functional outcome was measured before (post-op day 4) and after rTMS (post-op day 18). The rTMS group showed more functional improvement on the beam balance test and had stronger Bcl-2 and weaker Bax expression on immunohistochemistry compared with the sham group. The expression of NMDA and MAP-2 showed no significant difference between the two groups. These results suggest that rTMS in subacute cerebral ischemia has a therapeutic effect on functional recovery and is associated with an anti-apoptotic mechanism in the peri-ischemic area rather than with neural plasticity.

  1. Recovery from Binge Eating Disorder

    Science.gov (United States)

    Krentz, Adrienne; Chew, Judy; Arthur, Nancy

    2005-01-01

    The purpose of this study was to characterize the psychological processes of recovery from binge eating disorder (BED). A model was developed by asking the research question, "What is the experience of recovery for women with BED?" Unstructured interviews were conducted with six women who met the DSM-IV criteria for BED, and who were recovered…

  2. Superdiffusive gas recovery from nanopores

    Science.gov (United States)

    Wu, Haiyi; He, Yadong; Qiao, Rui

    2016-11-01

    Understanding the recovery of gas from reservoirs featuring pervasive nanopores is essential for effective shale gas extraction. Classical theories cannot accurately predict such gas recovery and many experimental observations are not well understood. Here we report molecular simulations of the recovery of gas from single nanopores, explicitly taking into account molecular gas-wall interactions. We show that, in very narrow pores, the strong gas-wall interactions are essential in determining the gas recovery behavior both quantitatively and qualitatively. These interactions cause the total diffusion coefficients of the gas molecules in nanopores to be smaller than those predicted by kinetic theories, hence slowing down the rate of gas recovery. These interactions also lead to significant adsorption of gas molecules on the pore walls. Because of the desorption of these gas molecules during gas recovery, the gas recovery from the nanopore does not exhibit the usual diffusive scaling law (i.e., the accumulative recovery scales as R ˜t1 /2 ) but follows a superdiffusive scaling law R ˜tn (n >0.5 ), which is similar to that observed in some field experiments. For the system studied here, the superdiffusive gas recovery scaling law can be captured well by continuum models in which the gas adsorption and desorption from pore walls are taken into account using the Langmuir model.

  3. Hydraulic fracturing to enhance geothermal energy recovery in deep and tight formations. Modell approach in petrothermy research project OPTIRISS

    Energy Technology Data Exchange (ETDEWEB)

    Rafiee, M.M.; Schmitz, S.; Barsch, M. [DBI - Gastechnologisches Institut gGmbH, Freiberg (Germany)

    2013-08-01

    energy recovery. Moreover the calibrated model can be used to optimize the heat exchanger in underground power plant. This work is done within the scope of the joint research project ''OPTIRISS - Development of a method for risk minimization petrothermal exploration and completion for middle German crystalline rocks'' which is funded by the development agency of Saxony (SAB)and development agency of Thueringen (TAB) (project number 30337/2796). (orig.)

  4. Modeling and optimization of integrated exhaust gas recirculation and multi-stage waste heat recovery in marine engines

    DEFF Research Database (Denmark)

    Kyriakidis, Fotis; Sørensen, Kim; Singh, Shobhana

    2017-01-01

    is optimized to utilize the maximum waste heat recovery. The Genetic algorithm and fmincon active-set algorithm are used to optimize the design and operation parameters for the two steam cycles. The optimization aims to find the theoretically optimal combination of the pressure levels and pinch......Waste heat recovery combined with exhaust gas recirculation is a promising technology that can address both the issue of NOx (nitrogen oxides) reduction and fuel savings by including a pressurized boiler. In the present study, a theoretical optimization of the performance of two different...

  5. Anatomically Correct Surface Recovery

    DEFF Research Database (Denmark)

    Jensen, Rasmus Ramsbøl; Nielsen, Jannik Boll; Larsen, Rasmus

    2015-01-01

    using the learned statistics. A quantitative evaluation is performed on a data set of 10 laser scans of ear canal impressions with minimal noise and artificial holes. We also present a qualitative evaluation on authentic partial scans from an actual direct in ear scanner prototype. Compared to a state......We present a method for 3D surface recovery in partial surface scans. The method is based on an Active Shape Model, which is used to predict missing data. The model is constructed using a bootstrap framework, where an initially small collection of hand-annotated samples is used to fit...... to and register unknown samples, resulting in an extensive statistical model. The statistical recovery uses a multivariate point prediction, where the distribution of the points is given by the Active Shape Model. We show how missing data in a partial scan, once point correspondence is achieved, can be predicted...

  6. Quantitative and temporal differential recovery of articular and muscular limitations of knee joint contractures; results in a rat model.

    Science.gov (United States)

    Trudel, Guy; Laneuville, Odette; Coletta, Elizabeth; Goudreau, Louis; Uhthoff, Hans K

    2014-10-01

    Joint contractures alter the mechanical properties of articular and muscular structures. Reversibility of a contracture depends on the restoration of the elasticity of both structures. We determined the differential contribution of articular and muscular structures to knee flexion contractures during spontaneous recovery. Rats (250, divided into 24 groups) had one knee joint surgically fixed in flexion for six different durations, from 1 to 32 wk, creating joint contractures of various severities. After the fixation was removed, the animals were left to spontaneously recover for 1 to 48 wk. After the recovery periods, animals were killed and the knee extension was measured before and after division of the transarticular posterior muscles using a motorized arthrometer. No articular limitation had developed in contracture of recent onset (≤2 wk of fixation, P > 0.05); muscular limitations were responsible for the majority of the contracture (34 ± 8° and 38 ± 6°, respectively; both P contractures of recent onset (1 and 2 wk of fixation, respectively). Long-lasting contractures (≥4 wk of fixation) presented articular limitations, irreversible in all 12 durations of recovery compared with controls (all 12 P contractures of recent onset were primarily due to muscular structures, and they were reversible during spontaneous recovery. Long-lasting contractures were primarily due to articular structures and were irreversible. Comprehensive temporal and quantitative data on the differential reversibility of mechanically significant alterations in articular and muscular structures represent novel evidence on which to base clinical practice. Copyright © 2014 the American Physiological Society.

  7. An Empirical Model for Carbon Recovery in a Rotating Belt Filter and Its Application in the Frame of Plantwide Evaluation

    DEFF Research Database (Denmark)

    Behera, Chitta Ranjan; Daynouri-Pancino, Farnaz; Santoro, Domenico

    2017-01-01

    and nutrient recovery in comparison to a conventional PC. Moreover, it is also believed that the RBF can fractionate carbon (enrichment of cellulose, namely toilet paper) based on particulate size, more efficiently than a PC. It is, therefore, necessary to understand and quantify the uniqueness of the RBF...

  8. Modeling the contribution of toxicokinetic and toxicodynamic processes to the recovery of gammarus pulex populations after exposure to pesticides

    NARCIS (Netherlands)

    Galic, N.G.; Ashauer, R.; Baveco, J.M.; Nyman, M.; Barsi, A.; Brink, van den P.J.

    2014-01-01

    Because aquatic macroinvertebrates may be exposed regularly to pesticides in edge-of-the-field water bodies, an accurate assessment of potential adverse effects and subsequent population recovery is essential. Standard effect risk assessment tools are not able to fully address the complexities arisi

  9. Linking mechanistic toxicology to population models in forecasting recovery from chemical stress: A case study from Jackfish Bay, Ontario, Canada

    Science.gov (United States)

    A Beneficial Use Impairment (BUI) common at Great Lakes Areas of Concern (AOCs) is loss of fish and wildlife populations. Consequently, recovery of populations after stressor mitigation serves as a basis for evaluating remediation success. We describe a framework that can be a...

  10. Does Poststroke Lower-Limb Spasticity Influence the Recovery of Standing Balance Control? A 2-Year Multilevel Growth Model.

    Science.gov (United States)

    Singer, Jonathan C; Nishihara, Kanako; Mochizuki, George

    2016-08-01

    Background Poststroke lower-limb spasticity (LLS) has been shown to degrade standing balance control by disrupting the temporal synchronization between individual limb centers of pressure (COPs). Time-varying changes in standing balance control associated with alterations in the extent of LLS have yet to be documented and are important to informing treatment strategies to improve such functional outcomes. Objective The present work aimed to understand the natural recovery of standing balance control among stroke survivors with LLS using limb-specific indices of standing balance control. Furthermore, we sought to understand if time-varying changes in LLS were associated with alterations in standing balance control. Methods A retrospective analysis of 92 participants was performed; 47 participants never exhibited LLS during the study (No_LLS), and 45 participants exhibited LLS during at least 1 testing session (LLS). Quiet standing for a duration of 30 s on 2 force platforms was recorded. Temporal synchrony and spatial symmetry of COP displacements were assessed, along with interlimb weight-bearing symmetry. Results All variables, except spatial symmetry, indicated initial improvement followed by deceleration in the rate of balance control recovery. Limb-specific measures indicated that individuals with LLS exhibited deficits in balance control. The recovery trajectories were not different between groups, suggesting a similar rate, but reduced extent, of balance control recovery among the LLS relative to the No_LLS group. Only temporal synchrony was altered by time-varying changes in spasticity. Conclusions The present results suggest that the reduction in spasticity may be beneficial to balance control recovery.

  11. Quantitative performance of advanced resolution recovery strategies on SPECT images: evaluation with use of digital phantom models.

    Science.gov (United States)

    Onishi, Hideo; Motomura, Nobutoku; Fujino, Koichi; Natsume, Takahiro; Haramoto, Yasuhiro

    2013-01-01

    Several resolution recovery (RR) methods have been developed. This study was aimed to validate the following performance of the advanced RR methods: Evolution, Astonish, Flash3D, and 3D-OSEM. We compared the advanced RR method with filtered back projection (FBP) and standard order-subset expectation maximization (OSEM) using resolution (RES), cylinder/sphere (CYS), and myocardial (MYD) digital phantoms. The RES phantom was placed in three spheres. Sixteen spheres (hot and cold) were then placed in a concentric configuration (diameter: 96-9.6 mm) inside the CYS phantom. The MYD phantom was created by computer simulation with the use of an electron γ-shower 4 (EGS4) and it included two left ventricular defects in the myocardium. The performance was evaluated at source-to-detector distances (R-distance) of 166, 200, and 250 mm with reconstruction parameters (product of subset and iteration: SI) with use of the resolution recovery factor, count recovery, normalized mean square error (NMSE), and %CV. According to increased SI updates, the value of the FWHM decreased, and the effect was more obvious as the R-distance increased. The spatial resolution of the advanced RR method was 20 % better than that of FBP and OSEM. The resolution recovery ratio was 80 %, and the count recovery was maintained only in objects with a diameter of >30 mm in the advanced RR method. The NMSE and %CV was 50 and 30 % improved over FBP and OSEM, respectively. The advanced RR method caused overestimation due to Gibbs's phenomenon in the marginal region when the diameter of the sphere was 16-28.8 mm.

  12. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model.

    Science.gov (United States)

    Lee, Hong J; Lim, In J; Lee, Min C; Kim, Seung U

    2010-11-15

    Intracerebral hemorrhage (ICH) is a lethal stroke type; mortality approaches 50%, and current medical therapy against ICH shows only limited effectiveness, so an alternative approach is required, such as stem cell-based cell therapy. Previously we have shown that intravenously transplanted human neural stem cells (NSCs) selectively migrate to the brain and promote functional recovery in rat ICH model, and others have shown that intracerebral infusion of brain-derived neurotrophic factor (BDNF) results in improved structural and functional outcome from cerebral ischemia. We postulated that human NSCs overexpressing BDNF transplanted into cerebral cortex overlying ICH lesion could provide improved survival of grafted NSCs and increased angiogenesis and behavioral recovery in mouse ICH model. ICH was induced in adult mice by injection of bacterial collagenase into striatum. The HB1.F3.BDNF (F3.BDNF) human NSC line produces sixfold higher amounts of BDNFF over the parental F3 cell line in vitro, induces behavioral improvement, and produces a threefold increase in cell survival at 2 weeks and 8 weeks posttransplantation. Brain transplantation of human NSCs overexpressing BDNF provided differentiation and survival of grafted human NSCs and renewed angiogenesis of host brain and functional recovery of ICH animals. These results indicate that the F3.BDNF human NSCs should be of great value as a cellular source for experimental studies involving cellular therapy for human neurological disorders, including ICH.

  13. Modeling and Experimental Validation of a Volumetric Expander Suitable for Waste Heat Recovery from an Automotive Internal Combustion Engine Using an Organic Rankine Cycle with Ethanol

    Directory of Open Access Journals (Sweden)

    José Galindo

    2016-04-01

    Full Text Available Waste heat recovery (WHR in exhaust gas flow of automotive engines has proved to be a useful path to increase the overall efficiency of internal combustion engines (ICE. Recovery potentials of up to 7% are shown in several works in the literature. However, most of them are theoretical estimations. Some present results from prototypes fed by steady flows generated in an auxiliary gas tank and not with actual engine exhaust gases. This paper deals with the modeling and experimental validation of an organic Rankine cycle (ORC with a swash-plate expander integrated in a 2 L turbocharged petrol engine using ethanol as working fluid. A global simulation model of the ORC was developed with a maximum difference of 5%, validated with experimental results. Considering the swash-plate as the main limiting factor, an additional specific submodel was implemented to model the physical phenomena in this element. This model allows simulating the fluid dynamic behavior of the swash-plate expander using a 0D model (Amesim. Differences up to 10.5% between tests and model results were found.

  14. Walking in Balance: Native American Recovery Programmes

    Directory of Open Access Journals (Sweden)

    Suzanne Owen

    2014-10-01

    Full Text Available This article reviews Native American ritual practices, frameworks and key concepts employed by several substance abuse treatments centres in the U.S. and Canada. It also examines the way Alcoholics Anonymous’ Twelve Step programme has been modified to attract and serve the needs of Native Americans and First Nations and its potential impact on the ritual practices. Native concepts of wellbeing are highlighted and linked to the idea of living in “balance”.

  15. Uses and abuses of recovery: implementing recovery-oriented practices in mental health systems

    Science.gov (United States)

    Slade, Mike; Amering, Michaela; Farkas, Marianne; Hamilton, Bridget; O'Hagan, Mary; Panther, Graham; Perkins, Rachel; Shepherd, Geoff; Tse, Samson; Whitley, Rob

    2014-01-01

    An understanding of recovery as a personal and subjective experience has emerged within mental health systems. This meaning of recovery now underpins mental health policy in many countries. Developing a focus on this type of recovery will involve transformation within mental health systems. Human systems do not easily transform. In this paper, we identify seven mis-uses (“abuses”) of the concept of recovery: recovery is the latest model; recovery does not apply to “my” patients; services can make people recover through effective treatment; compulsory detention and treatment aid recovery; a recovery orientation means closing services; recovery is about making people independent and normal; and contributing to society happens only after the person is recovered. We then identify ten empirically-validated interventions which support recovery, by targeting key recovery processes of connectedness, hope, identity, meaning and empowerment (the CHIME framework). The ten interventions are peer support workers, advance directives, wellness recovery action planning, illness management and recovery, REFOCUS, strengths model, recovery colleges or recovery education programs, individual placement and support, supported housing, and mental health trialogues. Finally, three scientific challenges are identified: broadening cultural understandings of recovery, implementing organizational transformation, and promoting citizenship. PMID:24497237

  16. Uses and abuses of recovery: implementing recovery-oriented practices in mental health systems.

    Science.gov (United States)

    Slade, Mike; Amering, Michaela; Farkas, Marianne; Hamilton, Bridget; O'Hagan, Mary; Panther, Graham; Perkins, Rachel; Shepherd, Geoff; Tse, Samson; Whitley, Rob

    2014-02-01

    An understanding of recovery as a personal and subjective experience has emerged within mental health systems. This meaning of recovery now underpins mental health policy in many countries. Developing a focus on this type of recovery will involve transformation within mental health systems. Human systems do not easily transform. In this paper, we identify seven mis-uses ("abuses") of the concept of recovery: recovery is the latest model; recovery does not apply to "my" patients; services can make people recover through effective treatment; compulsory detention and treatment aid recovery; a recovery orientation means closing services; recovery is about making people independent and normal; and contributing to society happens only after the person is recovered. We then identify ten empirically-validated interventions which support recovery, by targeting key recovery processes of connectedness, hope, identity, meaning and empowerment (the CHIME framework). The ten interventions are peer support workers, advance directives, wellness recovery action planning, illness management and recovery, REFOCUS, strengths model, recovery colleges or recovery education programs, individual placement and support, supported housing, and mental health trialogues. Finally, three scientific challenges are identified: broadening cultural understandings of recovery, implementing organizational transformation, and promoting citizenship.

  17. Numerical model of a thermoelectric generator with compact plate-fin heat exchanger for high temperature PEM fuel cell exhaust heat recovery

    DEFF Research Database (Denmark)

    Xin, Gao; Andreasen, Søren Juhl; Chen, Min

    2012-01-01

    This paper presents a numerical model of an exhaust heat recovery system for a high temperature polymer electrolyte membrane fuel cell (HTPEMFC) stack. The system is designed as thermoelectric generators (TEGs) sandwiched in the walls of a compact plate-fin heat exchanger. Its model is based...... plate-fin heat exchangers is adopted. Then the model is validated against experimental data and the main variables are identified by means of a sensitivity analysis. Finally, the system configuration is optimized for recovering heat from the exhaust gas. The results exhibit the crucial importance...... on a finite-element approach. On each discretized segment, fluid properties, heat transfer process and TEG performance are locally calculated for higher model precision. To benefit both the system design and fabrication, the way to model TEG modules is herein reconsidered; a database of commercialized compact...

  18. Design and modeling of an advanced marine machinery system including waste heat recovery and removal of sulphur oxides

    DEFF Research Database (Denmark)

    Frimann Nielsen, Rasmus; Haglind, Fredrik; Larsen, Ulrik

    2013-01-01

    In order to reduce the formation of acid rain and its harmful effects, stricter legislations on emissions of sulphur oxides from ships applies as of 2015 in emission control areas and globally in 2020 by the international maritime organization (IMO). Consequently, prices on low sulphur fuels...... of the machinery system. The wet sulphuric acid process has shown to be an effective way of removing sulphur oxides from flue gas of land-based coal fired power plants. Moreover, organic Rankine cycles are suitable for heat to power conversion for low temperature heat sources. This paper is aimed at designing......-stroke diesel engine and a conventional waste heat recovery system. The results suggest that an organic Rankine cycle placed after the conventional waste heat recovery system is able to extract the sulphuric acid from the exhaust gas, while at the same time increase power generation from waste heat by 32...

  19. Modelling and simulation of the energy recovery from hot steel pieces after an induction treatment by thermoelectricity

    OpenAIRE

    2010-01-01

    Thermoelectricity has a huge potential as an energy recovery technology in a large number of fields in which heat energy is lost and it is exactly what a thermogenerator needs to produce electricity, due to the Seebeck effect. In the steel production by induction furnace, at the end of the production process, the pieces retain a certain heat energy which nowadays is dissipated into the ambient cooling them. Using thermoelectricity to recover this energy is an opportunity to obt...

  20. Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.

    Science.gov (United States)

    Kanzaki, Akinori; Okauchi, Takashi; Hu, Di; Shingaki, Tomotaka; Katayama, Yumiko; Koyama, Hidenori; Watanabe, Yasuyoshi; Cui, Yilong

    2016-05-01

    Homeostasis is known to be involved in maintaining the optimal internal environment, helping to achieve the best performance of biological functions. At the same time, a deviation from optimal conditions often attenuates the performance of biological functions, and such restricted performance could be considered as individual fatigue, including physical and mental fatigue. The present study seeks to develop an animal model of chronic or subacute fatigue in which the recovery time is extended through the gradual disruption of homeostasis. We show that repeated short-term rest periods with certain lengths of sleep during continuous fatigue loading extend recovery from spontaneous nighttime activity but not physical performance in comparison with a continuous fatigue-loading procedure. Furthermore, the immobility time in a forced swimming test was extended by repeated short-term rests. These results suggest that repeated short-term rest with certain lengths of sleep during continuous fatigue loading is able to extend the recovery from mental fatigue but not from physical fatigue and that this effect might occur via the disruption of a homeostatic mechanism that is involved in restoring the optimal internal environment.

  1. Novel Anti-Adhesive CMC-PE Hydrogel Significantly Enhanced Morphological and Physiological Recovery after Surgical Decompression in an Animal Model of Entrapment Neuropathy

    Science.gov (United States)

    Urano, Hideki; Iwatsuki, Katsuyuki; Yamamoto, Michiro; Ohnisi, Tetsuro; Kurimoto, Shigeru; Endo, Nobuyuki; Hirata, Hitoshi

    2016-01-01

    We developed a novel hydrogel derived from sodium carboxymethylcellulose (CMC) in which phosphatidylethanolamine (PE) was introduced into the carboxyl groups of CMC to prevent perineural adhesions. This hydrogel has previously shown excellent anti-adhesive effects even after aggressive internal neurolysis in a rat model. Here, we confirmed the effects of the hydrogel on morphological and physiological recovery after nerve decompression. We prepared a rat model of chronic sciatic nerve compression using silicone tubing. Morphological and physiological recovery was confirmed at one, two, and three months after nerve decompression by assessing motor conduction velocity (MCV), the wet weight of the tibialis anterior muscle and morphometric evaluations of nerves. Electrophysiology showed significantly quicker recovery in the CMC-PE group than in the control group (24.0 ± 3.1 vs. 21.0± 2.1 m/s (p < 0.05) at one months and MCV continued to be significantly faster thereafter. Wet muscle weight at one month significantly differed between the CMC-PE (BW) and control groups (0.148 ± 0.020 vs. 0.108 ± 0.019%BW). The mean wet muscle weight was constantly higher in the CMC-PE group than in the control group throughout the experimental period. The axon area at one month was twice as large in the CMC-PE group compared with the control group (24.1 ± 17.3 vs. 12.3 ± 9 μm2) due to the higher ratio of axons with a larger diameter. Although the trend continued throughout the experimental period, the difference decreased after two months and was not statistically significant at three months. Although anti-adhesives can reduce adhesion after nerve injury, their effects on morphological and physiological recovery after surgical decompression of chronic entrapment neuropathy have not been investigated in detail. The present study showed that the new anti-adhesive CMC-PE gel can accelerate morphological and physiological recovery of nerves after decompression surgery. PMID:27741280

  2. Double Beta Distribution Model of Recovery Rate in Credit Risk%信用风险中回收率分布的双Beta模型

    Institute of Scientific and Technical Information of China (English)

    王国栋; 詹原瑞

    2011-01-01

    In this paper, the distribution of random recovery rate is studied, and double Beta distribution density model is established. This model has a characteristic of two peaks, which meets the new findings of Moody company, and improves the result that the present models all have only one peak. By using the sequential optimization algorithm based the NT-net to estimate parameters and the tools of kernel density estimation, the demonstration study is made. The result shows that the fitting error of double Beta model is quite little and far less than that of Beta model, so double Beta model is an ideal model to denote the distribution of recovery rate. The method is given to draw the random numbers from double Beta model at the end of the paper.%本文研究了随机回收率的分布,建立了回收率的双Beta分布密度模型,它具有双峰分布的特点,这与Moody公司的最新研究相吻合,弥补了现有回收率分布模型均为单峰的不足。利用基于数论网格的序贯优化算法对所建模型的参数做出了估计,借助于核密度估计的工具,进行了实证分析,结果表明双Beta模型的拟合误差很小,远小于Beta模型的误差,它是表示回收率理想的模型。最后给出了抽取双Beta分布随机数的方法。

  3. Deep Sequencing of Suppression Subtractive Hybridisation Drought and Recovery Libraries of the Non-model Crop Trifolium repens L.

    Science.gov (United States)

    Bisaga, Maciej; Lowe, Matthew; Hegarty, Matthew; Abberton, Michael; Ravagnani, Adriana

    2017-01-01

    White clover is a short-lived perennial whose persistence is greatly affected by abiotic stresses, particularly drought. The aim of this work was to characterize its molecular response to water deficit and recovery following re-hydration to identify targets for the breeding of tolerant varieties. We created a white clover reference transcriptome of 16,193 contigs by deep sequencing (mean base coverage 387x) four Suppression Subtractive Hybridization (SSH) libraries (a forward and a reverse library for each treatment) constructed from young leaf tissue of white clover at the onset of the response to drought and recovery. Reads from individual libraries were then mapped to the reference transcriptome and processed comparing expression level data. The pipeline generated four robust sets of transcripts induced and repressed in the leaves of plants subjected to water deficit stress (6,937 and 3,142, respectively) and following re-hydration (6,695 and 4,897, respectively). Semi-quantitative polymerase chain reaction was used to verify the expression pattern of 16 genes. The differentially expressed transcripts were functionally annotated and mapped to biological processes and pathways. In agreement with similar studies in other crops, the majority of transcripts up-regulated in response to drought belonged to metabolic processes, such as amino acid, carbohydrate, and lipid metabolism, while transcripts involved in photosynthesis, such as components of the photosystem and the biosynthesis of photosynthetic pigments, were up-regulated during recovery. The data also highlighted the role of raffinose family oligosaccharides (RFOs) and the possible delayed response of the flavonoid pathways in the initial response of white clover to water withdrawal. The work presented in this paper is to our knowledge the first large scale molecular analysis of the white clover response to drought stress and re-hydration. The data generated provide a valuable genomic resource for marker

  4. Design and modeling of an advanced marine machinery system including waste heat recovery and removal of sulphur oxides

    DEFF Research Database (Denmark)

    Frimann Nielsen, Rasmus; Haglind, Fredrik; Larsen, Ulrik

    2014-01-01

    that an ORC placed after the conventional waste heat recovery system is able to extract the sulphuric acid from the exhaust gas, while at the same time increase the combined cycle thermal efficiency by 2.6%. The findings indicate that the technology has potential in marine applications regarding both energy...... the efficiency of machinery systems. The wet sulphuric acid process is an effective way of removing flue gas sulphur oxides from land-based coal-fired power plants. Moreover, organic Rankine cycles (ORC) are suitable for heat to power conversion for low temperature heat sources. This paper describes the design...

  5. Comprehensive Energy Assessment: EE and RE Project Optimization Modeling for United States Pacific Command (USPACOM) American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance

    Energy Technology Data Exchange (ETDEWEB)

    Brigantic, Robert T.; Papatyi, Anthony F.; Perkins, Casey J.

    2010-09-30

    This report summarizes a study and corresponding model development conducted in support of the United States Pacific Command (USPACOM) as part of the Federal Energy Management Program (FEMP) American Reinvestment and Recovery Act (ARRA). This research was aimed at developing a mathematical programming framework and accompanying optimization methodology in order to simultaneously evaluate energy efficiency (EE) and renewable energy (RE) opportunities. Once developed, this research then demonstrated this methodology at a USPACOM installation - Camp H.M. Smith, Hawaii. We believe this is the first time such an integrated, joint EE and RE optimization methodology has been constructed and demonstrated.

  6. Energy recovery potential and life cycle impact assessment of municipal solid waste management technologies in Asian countries using ELP model

    Energy Technology Data Exchange (ETDEWEB)

    Pandyaswargo, Andante Hadi; Onoda, Hiroshi; Nagata, Katsuya [Waseda Univ., Saitama (Japan). Graduate School of Environment and Energy Engineering

    2012-11-01

    Natural resource scarcity and the effects of environmental destruction have pushed societies to use and reuse resources more efficiently. Waste should no longer be seen as a burden but rather as another source of material such as energy fuel. This study analyzes the potential of three waste management technologies - incineration with energy recovery, composting, and sanitary landfill gas collection - as ways to recover energy and material from municipal solid waste. The study applies the environmental load point (ELP) method and utilizes municipal waste characteristics and composition from India, Indonesia, and China as case studies. The ELP methodology employs integrated weighting in the quantification process to get a one-unit result. This study particularly uses analytic hierarchical process questionnaires to get the weighting value of the nine impact categories: energy depletion, global warming, ozone depletion, resource consumption, ecosystem influence, water pollution, waste disposal, air pollution, and acid rain. The results show that the scenario which includes composting organic waste and sanitary landfill with gas collection for energy recovery has medium environmental impact and the highest practicability. The optimum material and energy potential is from the Chinese case study in which 254 tonnes of compost fertilizer and 60 MWh of electricity is the estimated output for every 1,000 tonnes of waste treated. (orig.)

  7. Modeling of recovery mechanism of ozone zero phenomenaby adding small amount of nitrogen in atmospheric pressure oxygen dielectric barrier discharges

    Science.gov (United States)

    Akashi, Haruaki; Yoshinaga, Tomokazu

    2013-09-01

    Ozone zero phenomena in an atmospheric pressure oxygen dielectric barrier discharges have been one of the major problems during a long time operation of ozone generators. But it is also known that the adding a small amount of nitrogen makes the recover from the ozone zero phenomena. To make clear the mechanism of recovery, authors have been simulated the discharges with using the results of Ref. 3. As a result, the recovery process can be seen and ozone density increased. It is found that the most important species would be nitrogen atoms. The reaction of nitrogen atoms and oxygen molecules makes oxygen atoms which is main precursor species of ozone. This generation of oxygen atoms is effective to increase ozone. The dependence of oxygen atom density (nO) and nitrogen atom density (nN) ratio was examined in this paper. In the condition of low nN/nO ratio case, generation of nitrogen oxide is low, and the quenching of ozone by the nitrogen oxide would be low. But in the high ratio condition, the quenching of ozone by nitrogen oxide would significant. This work was supported by KAKENHI(23560352).

  8. Phenotypic analysis of cheese yields and nutrient recoveries in the curd of buffalo milk, as measured with an individual model cheese-manufacturing process.

    Science.gov (United States)

    Cipolat-Gotet, C; Bittante, G; Cecchinato, A

    2015-01-01

    Traits associated with cheese yield and milk nutrient recovery in curd are used to describe the efficiency of the cheese-making process. This is fundamental for all dairy species, including the Italian Mediterranean buffalo, which is largely used for milk production aimed at the dairy industry. To assess cheese-making traits among buffalo, a model cheese-manufacturing process was tested; it was capable of processing 24 samples per run, using 0.5-L samples of milk from individual buffalo. In total, 180 buffalo reared in 7 herds located in Northeast Italy were sampled once. Briefly, each sample was weighed and heated (35°C for 30min), inoculated with starter culture (90min), and mixed with rennet (51.2 international milk-clotting units/L of milk). After 10min of gelation, the curd was cut; 5min after the cut, the curd was separated from the whey, and the curd was subjected to draining (for 30min) and pressing (18h). The curd and whey were weighed, analyzed for pH and the total solid, fat, lactose, and protein contents, and subjected to estimation of the energy content. Three measures of cheese yield (%CY), %CYCURD, %CYSOLIDS, and %CYWATER, were computed as the ratios between the weight of the curd, the curd dry matter, and the water retained in the curd, respectively, and the weight of the milk processed. These traits were multiplied by the daily milk yield to define the 3 corresponding measures of daily cheese yield (dCY, kg/d). The milk component recoveries (REC) in the curd, RECFAT, RECPROTEIN, and RECSOLIDS, represented the ratios between the weights of the fat, protein, and total solids in the curd, respectively, and the corresponding components in the milk. Finally, energy recovery (RECENERGY) was estimated. The values for %CYCURD, %CYSOLIDS, %CYWATER, RECPROTEIN, RECFAT, RECSOLIDS, and RECENERGY averaged 25.6, 12.7, 12.9, 80.4, 95.1, 66.7, and 79.3%, respectively, indicating that buffalo milk has a higher aptitude to cheese-making than bovine milk. The effect

  9. 3-D RESERVOIR AND STOCHASTIC FRACTURE NETWORK MODELING FOR ENHANCED OIL RECOVERY, CIRCLE RIDGE PHOSPHORIA/TENSLEEP RESERVOIR, WIND RIVER RESERVATION, ARAPAHO AND SHOSHONE TRIBES, WYOMING

    Energy Technology Data Exchange (ETDEWEB)

    Paul La Pointe; Jan Hermanson; Robert Parney; Thorsten Eiben; Mike Dunleavy; Ken Steele; John Whitney; Darrell Eubanks; Roger Straub

    2002-11-18

    This report describes the results made in fulfillment of contract DE-FG26-00BC15190, ''3-D Reservoir and Stochastic Fracture Network Modeling for Enhanced Oil Recovery, Circle Ridge Phosphoria/Tensleep Reservoir, Wind River Reservation, Arapaho and Shoshone Tribes, Wyoming''. The goal of this project is to improve the recovery of oil from the Tensleep and Phosphoria Formations in Circle Ridge Oilfield, located on the Wind River Reservation in Wyoming, through an innovative integration of matrix characterization, structural reconstruction, and the characterization of the fracturing in the reservoir through the use of discrete fracture network models. Fields in which natural fractures dominate reservoir permeability, such as the Circle Ridge Field, often experience sub-optimal recovery when recovery processes are designed and implemented that do not take advantage of the fracture systems. For example, a conventional waterflood in a main structural block of the Field was implemented and later suspended due to unattractive results. It is estimated that somewhere less than 20% of the OOIP in the Circle Ridge Field have been recovered after more than 50 years' production. Marathon Oil Company identified the Circle Ridge Field as an attractive candidate for several advanced IOR processes that explicitly take advantage of the natural fracture system. These processes require knowledge of the distribution of matrix porosity, permeability and oil saturations; and understanding of where fracturing is likely to be well-developed or poorly developed; how the fracturing may compartmentalize the reservoir; and how smaller, relatively untested subthrust fault blocks may be connected to the main overthrust block. For this reason, the project focused on improving knowledge of the matrix properties, the fault block architecture and to develop a model that could be used to predict fracture intensity, orientation and fluid flow/connectivity properties. Knowledge

  10. Marrow-isolated adult multilineage inducible cells embedded within a biologically-inspired construct promote recovery in a mouse model of peripheral vascular disease.

    Science.gov (United States)

    Grau-Monge, Cristina; Delcroix, Gaëtan J-R; Bonnin-Marquez, Andrea; Valdes, Mike; Awadallah, Ead Lewis Mazen; Quevedo, Daniel F; Armour, Maxime R; Montero, Ramon B; Schiller, Paul C; Andreopoulos, Fotios M; D'Ippolito, Gianluca

    2017-02-17

    Peripheral vascular disease is one of the major vascular complications in individuals suffering from diabetes and in the elderly that is associated with significant burden in terms of morbidity and mortality. Stem cell therapy is being tested as an attractive alternative to traditional surgery to prevent and treat this disorder. The goal of this study was to enhance the protective and reparative potential of marrow-isolated adult multilineage inducible (MIAMI) cells by incorporating them within a bio-inspired construct (BIC) made of two layers of gelatin B electrospun nanofibers. We hypothesized that the BIC would enhance MIAMI cell survival and engraftment, ultimately leading to a better functional recovery of the injured limb in our mouse model of critical limb ischemia compared to MIAMI cells used alone. Our study demonstrated that MIAMI cell-seeded BIC resulted in a wide range of positive outcomes with an almost full recovery of blood flow in the injured limb, thereby limiting the extent of ischemia and necrosis. Functional recovery was also the greatest when MIAMI cells were combined with BICs, compared to MIAMI cells alone or BICs in the absence of cells. Histology was performed 28 days after grafting the animals to explore the mechanisms at the source of these positive outcomes. We observed that our critical limb ischemia model induces an extensive loss of muscular fibers that are replaced by intermuscular adipose tissue (IMAT), together with a highly disorganized vascular structure. The use of MIAMI cells-seeded BIC prevented IMAT infiltration with some clear evidence of muscular fibers regeneration.

  11. Gasoline Vapor Recovery

    Science.gov (United States)

    1979-01-01

    Gasoline is volatile and some of it evaporates during storage, giving off hydrocarbon vapor. Formerly, the vapor was vented into the atmosphere but anti-pollution regulations have precluded that practice in many localities, so oil companies and storage terminals are installing systems to recover hydrocarbon vapor. Recovery provides an energy conservation bonus in that most of the vapor can be reconverted to gasoline. Two such recovery systems are shown in the accompanying photographs (mid-photo at right and in the foreground below). They are actually two models of the same system, although.configured differently because they are customized to users' needs. They were developed and are being manufactured by Edwards Engineering Corporation, Pompton Plains, New Jersey. NASA technological information proved useful in development of the equipment.

  12. Acute hypothalamic suppression significantly affects trabecular bone but not cortical bone following recovery and ovariectomy surgery in a rat model

    Directory of Open Access Journals (Sweden)

    Vanessa R. Yingling

    2016-01-01

    Full Text Available Background. Osteoporosis is “a pediatric disease with geriatric consequences.” Bone morphology and tissue quality co-adapt during ontogeny for sufficient bone stiffness. Altered bone morphology from hypothalamic amenorrhea, a risk factor for low bone mass in women, may affect bone strength later in life. Our purpose was to determine if altered morphology following hypothalamic suppression during development affects cortical bone strength and trabecular bone volume (BV/TV at maturity.Methods. Female rats (25 days old were assigned to a control (C group (n = 45 that received saline injections (.2 cc or an experimental group (GnRH-a (n = 45 that received gonadotropin releasing hormone antagonist injections (.24 mg per dose for 25 days. Fifteen animals from each group were sacrificed immediately after the injection protocol at Day 50 (C, GnRH-a. The remaining animals recovered for 135 days and a subset of each group was sacrificed at Day 185 ((C-R (n = 15 and (G-R (n = 15. The remaining animals had an ovariectomy surgery (OVX at 185 days of age and were sacrificed 40 days later (C-OVX (n = 15 and (G-OVX (n = 15. After sacrifice femurs were mechanically tested and scanned using micro CT. Serum C-terminal telopeptides (CTX and insulin-like growth factor 1 (IGF-1 were measured. Two-way ANOVA (2 groups (GnRH-a and Control X 3 time points (Injection Protocol, Recovery, post-OVX was computed.Results. GnRH-a injections suppressed uterine weights (72% and increased CTX levels by 59%. Bone stiffness was greater in the GnRH-a groups compared to C. Ash content and cortical bone area were similar between groups at all time points. Polar moment of inertia, a measure of bone architecture, was 15% larger in the GnRH-a group and remained larger than C (19% following recovery. Both the polar moment of inertia and cortical area increased linearly with the increases in body weight. Following the injection protocol, trabecular BV/TV was 31% lower in the Gn

  13. Development of a pyrolysis waste recovery model with designs, test plans, and applications for space-based habitats

    Science.gov (United States)

    Roberson, Bobby J.

    1992-01-01

    Extensive literature searches revealed the numerous advantages of using pyrolysis as a means of recovering usable resources from inedible plant biomass, paper, plastics, other polymers, and human waste. A possible design of a pyrolysis reactor with test plans and applications for use on a space-based habitat are proposed. The proposed system will accommodate the wastes generated by a four-person crew while requiring solar energy as the only power source. Waste materials will be collected and stored during the 15-day lunar darkness periods. Resource recovery will occur during the daylight periods. Usable gases such as methane and hydrogen and a solid char will be produced while reducing the mass and volume of the waste to almost infinitely small levels. The system will be operated economically, safely, and in a non-polluting manner.

  14. Integrated use of ultra scale-down and financial modeling to identify optimal conditions for the precipitation and centrifugal recovery of milk proteins.

    Science.gov (United States)

    Chhatre, Sunil; Pampel, Lars; Titchener-Hooker, Nigel J

    2011-07-01

    This article investigates the integrated application of ultra scale-down (USD) techniques and economic modeling as a means for identifying optimal bioprocess operating conditions. The benefits of the approach are illustrated for the recovery of lactoperoxidase (LPO) from bovine milk. In the process, milk is skimmed to deplete its lipid content, before being subjected to low pH incubation with acetic acid in order to precipitate the primary impurity (casein). Following removal of the solids by disk stack centrifugation, pH adjustment and filtration, cation exchange chromatography is used as a positive mode column step to bind the LPO before it is polished and freeze dried. An economic model of this process was used to identify where greatest product loss occurs and hence where the largest opportunity cost was being incurred. Scale-down analysis was used to characterize the influence of the critical steps, identified as precipitation and centrifugation, upon LPO recovery. A mathematical model was used to relate the centrifuge feed flowrate and discharge interval to the supernatant yield, and it was shown that increasing the centrifugal solids residence time achieved superior solids de-watering and so higher product yield, although this also increased the overall processing time. To resolve this conflict, scale-down data were used again in conjunction with an economic model to determine the most suitable conditions that maximized annual profit and minimized operating costs. The results demonstrate the power of combining USD data with models of economic and process performance in order to establish the best overall operating strategies for biopharmaceutical manufacture.

  15. Recovery and Resilience After a Nuclear Power Plant Disaster: A Medical Decision model for Managing an Effective, Timely, and Balanced Response

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, C. Norman [National Cancer Institute, NIH; Blumenthal, Daniel J. [National Nuclear Security Administration (NNSA), Department of Energy

    2013-05-01

    Based on experiences in Tokyo responding to the Fukushima Daiichi nuclear power plant crisis, a real-time, medical decision model is presented by which to make key health-related decisions given the central role of health and medical issues in such disasters. Focus is on response and recovery activities that are safe, timely, effective, and well-organized. This approach empowers on-site decision makers to make interim decisions without undue delay using readily available and high-level scientific, medical, communication, and policy expertise. Key features of this approach include ongoing assessment, consultation, information, and adaption to the changing conditions. This medical decision model presented is compatible with the existing US National Response Framework structure.

  16. A stochastically forced time delay solar dynamo model: Self-consistent recovery from a maunder-like grand minimum necessitates a mean-field alpha effect

    Energy Technology Data Exchange (ETDEWEB)

    Hazra, Soumitra; Nandy, Dibyendu [Department of Physical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal (India); Passos, Dário, E-mail: s.hazra@iiserkol.ac.in, E-mail: dariopassos@ist.utl.pt, E-mail: dnandi@iiserkol.ac.in [CENTRA-IST, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal)

    2014-07-01

    Fluctuations in the Sun's magnetic activity, including episodes of grand minima such as the Maunder minimum have important consequences for space and planetary environments. However, the underlying dynamics of such extreme fluctuations remain ill-understood. Here, we use a novel mathematical model based on stochastically forced, non-linear delay differential equations to study solar cycle fluctuations in which time delays capture the physics of magnetic flux transport between spatially segregated dynamo source regions in the solar interior. Using this model, we explicitly demonstrate that the Babcock-Leighton poloidal field source based on dispersal of tilted bipolar sunspot flux, alone, cannot recover the sunspot cycle from a grand minimum. We find that an additional poloidal field source effective on weak fields—e.g., the mean-field α effect driven by helical turbulence—is necessary for self-consistent recovery of the sunspot cycle from grand minima episodes.

  17. Electrophysiological functional recovery in a rat model of spinal cord hemisection injury following bone marrow-derived mesenchymal stem cell transplantation under hypothermia

    Institute of Scientific and Technical Information of China (English)

    Dong Wang; Jianjun Zhang

    2012-01-01

    Following successful establishment of a rat model of spinal cord hemisection injury by resecting right spinal cord tissues, bone marrow stem cells were transplanted into the spinal cord lesions via the caudal vein while maintaining rectal temperature at 34 ± 0.5°C for 6 hours (mild hypothermia). Hematoxylin-eosin staining showed that astrocytes gathered around the injury site and formed scars at 4 weeks post-transplantation. Compared with rats transplanted with bone marrow stem cells under normal temperature, rats transplanted with bone marrow stem cells under hypothermia showed increased numbers of proliferating cells (bromodeoxyuridine-positive cells), better recovery of somatosensory-evoked and motor-evoked potentials, greater Basso, Beattie, and Bresnahan locomotor rating scores, and an increased degree of angle in the incline plate test. These findings suggested that hypothermia combined with bone marrow mesenchymal stem cells transplantation effectively promoted electrical conduction and nerve functional repair in a rat model of spinal cord hemisection injury.

  18. Recovery of lactic acid from the pretreated fermentation broth based on a novel hyper-cross-linked meso-micropore resin: Modeling.

    Science.gov (United States)

    Song, Mingkai; Jiao, Pengfei; Qin, Taotao; Jiang, Kangkang; Zhou, Jingwei; Zhuang, Wei; Chen, Yong; Liu, Dong; Zhu, Chenjie; Chen, Xiaochun; Ying, Hanjie; Wu, Jinglan

    2017-10-01

    An innovative benign process for recovery lactic acid from its fermentation broth is proposed using a novel hyper-cross-linked meso-micropore resin and water as eluent. This work focuses on modeling the competitive adsorption behaviors of glucose, lactic acid and acetic acid ternary mixture and explosion of the adsorption mechanism. The characterization results showed the resin had a large BET surface area and specific pore structure with hydrophobic properties. By analysis of the physicochemical properties of the solutes and the resin, the mechanism of the separation is proposed as hydrophobic effect and size-exclusion. Subsequently three chromatographic models were applied to predict the competitive breakthrough curves of the ternary mixture under different operating conditions. The pore diffusion was the major limiting factor for the adsorption process, which was consistent with the BET results. The novel HD-06 resin can be a good potential adsorbent for the future SMB continuous separation process. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI.

    Science.gov (United States)

    Khan, Mushfiquddin; Dhammu, Tajinder S; Matsuda, Fumiyo; Annamalai, Balasubramaniam; Dhindsa, Tejbir Singh; Singh, Inderjit; Singh, Avtar K

    2016-01-01

    Traumatic brain injury (TBI) derails nitric oxide (NO)-based anti-inflammatory and anti-excitotoxicity mechanisms. NO is consumed by superoxide to form peroxynitrite, leading to decreased NO bioavailability for S-nitrosoglutathione (GSNO) synthesis and regulation of neuroprotective pathways. Neuronal peroxynitrite is implicated in neuronal loss and functional deficits following TBI. Using a contusion mouse model of TBI, we investigated mechanisms for the opposed roles of GSNO versus peroxynitrite for neuroprotection and functional recovery. TBI was induced by controlled cortical impact (CCI) in adult male mice. GSNO treatment at 2h after CCI decreased the expression levels of phospho neuronal nitric oxide synthase (pnNOS), alpha II spectrin degraded products, and 3-NT, while also decreasing the activities of nNOS and calpains. Treatment of TBI with FeTPPS, a peroxynitrite scavenger, had effects similar to GSNO treatment. GSNO treatment of TBI also reduced neuronal degeneration and improved neurobehavioral function in a two-week TBI study. In a cell free system, SIN-1 (a peroxynitrite donor and 3-nitrotyrosinating agent) increased whereas GSNO (an S-nitrosylating agent) decreased calpain activity, and these activities were reversed by, respectively, FeTPPS and mercuric chloride, a cysteine-NO bond cleaving agent. These data indicate that peroxynitrite-mediated activation and GSNO-mediated inhibition of the deleterious nNOS/calpain system play critical roles in the pathobiology of neuronal protection and functional recovery in TBI disease. Given GSNO׳s safety record in other diseases, its neuroprotective efficacy and promotion of functional recovery in this TBI study make low-dose GSNO a potential candidate for preclinical evaluation.

  20. Modeling the effects of potential salinity shifts on the recovery of striped bass in the Savannah River estuary, Georgia-South Carolina, United States

    Science.gov (United States)

    Reinert, T.R.; Peterson, J.T.

    2008-01-01

    Increased salinity in spawning and nursery grounds in the Savannah River estuary was cited as the primary cause of a 97% decrease in adult striped bass (Morone saxatilis) and a concomitant 96% decrease in striped bass egg production. Restoration efforts focused on environmental remediation and stock enhancement have resulted in restored salinity patterns and increased egg and adult abundances. However, future water needs or harbor development may preclude further recovery by reducing freshwater inflow or increasing salinity intrusion. To assess the effect of potential changes in the salinity regime, we developed models relating discharge, tidal phase, and salinity to striped bass egg and early larval survival and re-cast these in a quantitative Bayesian belief network. The model indicated that a small upstream shift (???1.67 km) in the salinity regime would have the least impact on striped bass early life history survival, whereas shifts >1.67 km would have progressively larger impacts, with a 8.33-km shift potentially reducing our estimated survival probability by >28%. Such an impact could have cumulative and long-term detrimental effects on the recovery of the Savannah River striped bass population. The available salinity data were collected during average and low flows, so our model represents some typical and some extreme conditions during a striped bass spawning season. Our model is a relatively simplistic, "first-order" attempt at evaluating potential effects of changes in the Savannah River estuarine salinity regime and points to areas of concern and potential future research. ?? 2008 Springer Science+Business Media, LLC.

  1. Radiation damage, repopulation and cell recovery analysis of in vitro tumour cell megacolony culture data using a non-Poissonian cell repopulation TCP model

    Science.gov (United States)

    Stavrev, P.; Weldon, M.; Warkentin, B.; Stavreva, N.; Fallone, B. G.

    2005-07-01

    The effects of radiation damage, tumour repopulation and cell sublethal damage repair and the possibility of extracting information about the model parameters describing them are investigated in this work. Previously published data on two different cultured cell lines were analysed with the help of a tumour control probability (TCP) model that describes tumour cell dynamics properly. Different versions of a TCP model representing the cases of full or partial cell recovery between fractions of radiation, accompanied by repopulation or no repopulation were used to fit the data and were ranked according to statistical criteria. The data analysis shows the importance of the linear-quadratic mechanism of cell damage for the description of the in vitro cell dynamics. In a previous work where in vivo data were analysed, the employment of the single hit model of cell kill and cell repopulation produced the best fit, while ignoring the quadratic term of cell damage in the current analysis leads to poor fits. It is also concluded that more experiments using different fractionation regimes producing diverse data are needed to help model analysis and better ranking of the models.

  2. S-R Associations, Their Extinction, and Recovery in an Animal Model of Anxiety: A New Associative Account of Phobias Without Recall of Original Trauma

    Science.gov (United States)

    Laborda, Mario A.; Miller, Ralph R.

    2012-01-01

    Associative accounts of the etiology of phobias have been criticized because of numerous cases of phobias in which the client does not remember a relevant traumatic event (i.e., Pavlovian conditioning trial), instructions, or vicarious experience with the phobic object. In three lick suppression experiments with rats as subjects, we modeled an associative account of such fears. Experiment 1 assessed stimulus-response (S-R) associations in first-order fear conditioning. After behaviorally complete devaluation of the unconditioned stimulus, the target stimulus still produced strong conditioned responses, suggesting that an S-R association had been formed and that this association was not significantly affected when the outcome was devalued through unsignaled presentations of the unconditioned stimulus. Experiments 2 and 3 examined extinction and recovery of S-R associations. Experiment 2 showed that extinguished S-R associations returned when testing occurred outside of the extinction context (i.e., renewal) and Experiment 3 found that a long delay between extinction and testing also produced a return of the extinguished S-R associations (i.e., spontaneous recovery). These experiments suggest that fears for which people cannot recall a cause are explicable in an associative framework, and indicate that those fears are susceptible to relapse after extinction treatment just like stimulus-outcome (S-O) associations. PMID:21496503

  3. Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury.

    Science.gov (United States)

    Kaplan, Tolga; Kafa, Ilker Mustafa; Cansev, Mehmet; Bekar, Ahmet; Karli, Necdet; Taskapilioglu, Mevlut Ozgur; Kanar, Fulya

    2014-01-01

    The aim of this study was to investigate the dose dependence of citicoline's previously-reported effects on recovery of peripheral nerve injury. Right sciatic nerves of sixty adult female Wistar Albino rats were incised and primary anastomosis was performed. Rats were then divided into four groups: Control group received 2 ml of saline intraperitoneally, while rats in C-300, C-600 and C-900 groups received 300 μmol/kg, 600 μmol/kg and 900 μmol/kg citicoline dissolved in 2 ml saline, respectively. Rats were tested for sciatic functional index (SFI) on the 4th, 8th and 12th weeks and electrophysiological recordings were obtained on the 12th week. Rats were then sacrificed to investigate nerve adhesions and perform histomorphological examinations. Our results showed that rats in C-600 and C-900 groups had significantly lesser neural adhesion and greater SFI and electrophysiological score than those in the Control and C-300 groups (p < 0.05). Mean density and total number of functionally myelinated axons were significantly increased in C-900 group, while perineural scar tissue formation was reduced in all citicoline-treated groups. We conclude that citicoline exhibits dose-dependent effects on axonal regeneration and recovery without scar formation in a rat model of peripheral nerve incision and primary anastomosis.

  4. Nerve growth factor injected systemically improves the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis.

    Science.gov (United States)

    Du, Zhao-jie; Wang, Lei; Lei, De-lin; Liu, Bao-lin; Cao, Jian; Zhang, Pu; Ma, Qin

    2011-10-01

    Our aim was to find out if nerve growth factor (NGF) injected systemically could improve the recovery of the inferior alveolar nerve in a rabbit model of mandibular distraction osteogenesis. We used 48 New Zealand white rabbits that were treated with bilateral distraction osteogenesis at a rate of 0.5mm/12h for 10 days. Immediately postoperatively, NGF or sodium chloride 0.6 μg/day was injected intramuscularly for 20 days. At the end of distraction and after consolidation times of 1, 2, and 4 weeks, the inferior alveolar nerves were evaluated histologically and histomorphometrically. Histologically, at 2 and 4 weeks there was less myelin debris, and more regenerating axons were present, in the NGF than the control groups. The density of myelinated axons was significantly greater in groups with NGF than controls at 2 and 4 weeks (pNGF given systemically can accelerate the recovery of the inferior alveolar nerve in rabbits after mandibular distraction osteogenesis, and is a promising treatment option for neurological complications of mandibular distraction osteogenesis.

  5. Influence of pH on dynamics of microbial enhanced oil recovery processes using biosurfactant producing Pseudomonas putida: Mathematical modelling and numerical simulation.

    Science.gov (United States)

    Sivasankar, P; Suresh Kumar, G

    2017-01-01

    In present work, the influence of reservoir pH conditions on dynamics of microbial enhanced oil recovery (MEOR) processes using Pseudomonas putida was analysed numerically from the developed mathematical model for MEOR processes. Further, a new strategy to improve the MEOR performance has also been proposed. It is concluded from present study that by reversing the reservoir pH from highly acidic to low alkaline condition (pH 5-8), flow and mobility of displaced oil, displacement efficiency, and original oil in place (OOIP) recovered gets significantly enhanced, resulting from improved interfacial tension (IFT) reduction by biosurfactants. At pH 8, maximum of 26.1% of OOIP was recovered with higher displacement efficiency. The present study introduces a new strategy to increase the recovery efficiency of MEOR technique by characterizing the biosurfactants for IFTmin/IFTmax values for different pH conditions and subsequently, reversing the reservoir pH conditions at which the IFTmin/IFTmax value is minimum. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Targeting RPTPσ with lentiviral shRNA promotes neurites outgrowth of cortical neurons and improves functional recovery in a rat spinal cord contusion model.

    Science.gov (United States)

    Zhou, Heng-Xing; Li, Xue-Ying; Li, Fu-Yuan; Liu, Chang; Liang, Zhi-Pin; Liu, Shen; Zhang, Bin; Wang, Tian-Yi; Chu, Tian-Ci; Lu, Lu; Ning, Guang-Zhi; Kong, Xiao-Hong; Feng, Shi-Qing

    2014-10-24

    After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition have been tested, no successful method with clinical feasibility has been devised to date. It was recently discovered that receptor protein tyrosine phosphatase sigma (RPTPσ) is a functional receptor for CSPGs-mediated inhibition. In view of the potential clinical application of RNA interference (RNAi), here we investigated whether silencing RPTPσ via lentivirus-mediated RNA interference can promote axon regeneration and functional recovery after SCI. Neurites of primary rat cerebral cortical neurons with depleted RPTPσ exhibited a significant enhancement in elongation and crossing ability when they encountered CSPGs in vitro. A contusion model of spinal cord injury in Wistar rats (the New York University (NYU) impactor) was used for in vivo experiments. Local injection of lentivirus encoding RPTPσ shRNA at the lesion site promoted axon regeneration and synapse formation, but did not affect the scar formation. Meanwhile, in vivo functional recovery (motor and sensory) was also enhanced after RPTPσ depletion. Therefore, strategies directed at silencing RPTPσ by RNAi may prove to be a beneficial, efficient and valuable approach for the treatment of SCI. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Benefits and costs associated with mutual-help community-based recovery homes: The Oxford House model.

    Science.gov (United States)

    Lo Sasso, Anthony T; Byro, Erik; Jason, Leonard A; Ferrari, Joseph R; Olson, Bradley

    2012-02-01

    We used data from a randomized controlled study of Oxford House (OH), a self-run, self-supporting recovery home, to conduct a cost-benefit analysis of the program. Following substance abuse treatment, individuals that were assigned to an OH condition (n=68) were compared to individuals assigned to a usual care condition (n=61). Economic cost measures were derived from length of stay at an Oxford House residence, and derived from self-reported measures of inpatient and outpatient treatment utilization. Economic benefit measures were derived from self-reported information on monthly income, days participating in illegal activities, binary responses of alcohol and drug use, and incarceration. Results suggest that OH compared quite favorably to usual care: the net benefit of an OH stay was estimated to be roughly $29,000 per person on average. Bootstrapped standard errors suggested that the net benefit was statistically significant. Costs were incrementally higher under OH, but the benefits in terms of reduced illegal activity, incarceration and substance use substantially outweighed the costs. The positive net benefit for Oxford House is primarily driven by a large difference in illegal activity between OH and usual care participants. Using sensitivity analyses, under more conservative assumptions we still arrived at a net benefit favorable to OH of $17,830 per person. Copyright © 2011 Elsevier Ltd. All rights reserved.

  8. Uncovering Recovery: The Resistible Rise of Recovery and Resilience

    Directory of Open Access Journals (Sweden)

    David Harper

    2012-10-01

    Full Text Available Discourses of recovery and resilience have risen to positions of dominance in the mental health field. Models of recovery and resilience enjoy purchase, in both policy and practice, across a range of settings from self-described psychiatric survivors through to mental health charities through to statutory mental health service providers. Despite this ubiquity, there is confusion about what recovery means. In this article we problematize notions of recovery and resilience, and consider what, if anything, should be recovered from these concepts. We focus on three key issues, i individualization, ii the persistence of a deficit model, and iii collective approaches to recovery. Through documentary analysis we consider these issues across third sector organizations, and public and mental health policy. Firstly, definitional debates about recovery reflect wider ideological debates about the nature of mental health. The vagueness of these concepts and implicit assumptions inherent in dominant recovery and resilience discourses render them problematic because they individualize what are social problems. Secondly, these discourses, despite being seen as inherently liberatory are conceptually dependent on a notion of deficit in that talk of “positives” and “strengths” requires the existence of “negatives” and “weaknesses” for these concepts to make sense.  We argue that this does little to substantially transform dominant understandings of psychological distress. Thirdly, these issues combine to impact upon the progressive potential of recovery. It comes to be seen as an individualistic experiential narrative accompaniment to medical understandings where the structural causes of distress are obscured. This in turn impacts upon the potential for recovery to be used to explore more collective, political aspects of emotional distress. Drawing on the work of Fraser, we use this critique to characterize “recovery” as a “struggle for

  9. The Atlas3D project - XII. Recovery of the mass-to-light ratio of simulated early-type barred galaxies with axisymmetric dynamical models

    CERN Document Server

    Lablanche, Pierre-Yves; Emsellem, Eric; Bournaud, Frederic; Michel-Dansac, Leo; Alatalo, Katherine; Blitz, Leo; Bois, Maxime; Bureau, Martin; Davies, Roger L; Davis, Timothy A; de Zeeuw, P T; Duc, Pierre-Alain; Khochfar, Sadegh; Krajnovic, Davor; Kuntschner, Harald; Morganti, Raffaella; McDermid, Richard M; Naab, Thorsten; Oosterloo, Tom; Sarzi, Marc; Scott, Nicholas; Serra, Paolo; Weijmans, Anne-Marie; Young, Lisa M

    2012-01-01

    We investigate the accuracy in the recovery of the stellar dynamics of barred galaxies when using axisymmetric dynamical models. We do this by trying to recover the mass-to-light ratio (M/L) and the anisotropy of realistic galaxy simulations using the Jeans Anisotropic Multi-Gaussian Expansion (JAM) method. However, given that the biases we find are mostly due to an application of an axisymmetric modeling algorithm to a non-axisymmetric system and in particular to inaccuracies in the de-projected mass model, our results are relevant for general axisymmetric modelling methods. We run N-body collisionless simulations to build a library with various luminosity distribution, constructed to mimic real individual galaxies, with realistic anisotropy. The final result of our evolved library of simulations contains both barred and unbarred galaxies. The JAM method assumes an axisymmetric mass distribution, and we adopt a spatially constant M/L and anisotropy beta_z=1-sigma_z^2/sigma_R^2 distributions. The models are f...

  10. Energy Recovery

    Science.gov (United States)

    1987-01-01

    The United States and other countries face the problem of waste disposal in an economical, environmentally safe manner. A widely applied solution adopted by Americans is "waste to energy," incinerating the refuse and using the steam produced by trash burning to drive an electricity producing generator. NASA's computer program PRESTO II, (Performance of Regenerative Superheated Steam Turbine Cycles), provides power engineering companies, including Blount Energy Resources Corporation of Alabama, with the ability to model such features as process steam extraction, induction and feedwater heating by external sources, peaking and high back pressure. Expansion line efficiency, exhaust loss, leakage, mechanical losses and generator losses are used to calculate the cycle heat rate. The generator output program is sufficiently precise that it can be used to verify performance quoted in turbine generator supplier's proposals.

  11. Passive immunization with LINGO-1 polyclonal antiserum afforded neuroprotection and promoted functional recovery in a rat model of spinal cord injury.

    Science.gov (United States)

    Lv, Jun; Xu, Ru-xiang; Jiang, Xiao-dan; Lu, Xin; Ke, Yi-quan; Cai, Ying-qian; Du, Mou-xuan; Hu, Changchen; Zou, Yu-xi; Qin, Ling-sha; Zeng, Yan-jun

    2010-01-01

    LINGO-1 (leucine-rich repeat and Ig domain-containing, Nogo receptor-interacting protein) is an important component of the NgR receptor complex involved in RhoA activation and axon regeneration. The authors report on passive immunization with LINGO-1 polyclonal antiserum, a therapeutic approach to overcome NgR-mediated growth inhibition after spinal cord injury (SCI). The intrathecally administered high-titer rabbit-derived antiserum can be detected around the injury site within a wide time window; it blocks LINGO-1 in vivo with high molecular specificity. In this animal model, passive immunization with LINGO-1 antiserum significantly decreased RhoA activation and increased neuronal survival. Adult rats immunized in this manner show recovery of certain hindlimb motor functions after dorsal hemisection of the spinal cord. Thus, passive immunotherapy with LINGO-1 polyclonal antiserum may represent a promising repair strategy following acute SCI.

  12. Modeling of cell culture damage and recovery leads to increased antibody and biomass productivity in CHO cell cultures.

    Science.gov (United States)

    Naderi, Saeideh; Nikdel, Ali; Meshram, Mukesh; McConkey, Brendan; Ingalls, Brian; Budman, Hector; Scharer, Jeno

    2014-09-01

    The development of an efficient and productive cell-culture process requires a deep understanding of intracellular mechanisms and extracellular conditions for optimal product synthesis. Mathematical modeling provides an effective strategy to predict, control, and optimize cell performance under a range of culture conditions. In this study, a mathematical model is proposed for the investigation of cell damage of a Chinese hamster ovary cell culture secreting recombinant anti-RhD monoclonal antibody (mAb). Irreversible cell damage was found to be correlated with a reduction in pH. This irreversible damage to cellular function is described mathematically by a Tessier-based model, in which the actively growing fraction of cells is dependent on an intracellular metabolic product acting as a growth inhibitor. To further verify the model, an offline model-based optimization of mAb production in the cell culture was carried out, with the goal of minimizing cell damage and thereby enhancing productivity through intermittent refreshment of the culture medium. An experimental implementation of this model-based strategy resulted in a doubling of the yield as compared to the batch operation and the resulting biomass and productivity profiles agreed with the model predictions.

  13. Granulocyte-colony stimulating factor (G-CSF improves motor recovery in the rat impactor model for spinal cord injury.

    Directory of Open Access Journals (Sweden)

    Tanjew Dittgen

    Full Text Available Granulocyte-colony stimulating factor (G-CSF improves outcome after experimental SCI by counteracting apoptosis, and enhancing connectivity in the injured spinal cord. Previously we have employed the mouse hemisection SCI model and studied motor function after subcutaneous or transgenic delivery of the protein. To further broaden confidence in animal efficacy data we sought to determine efficacy in a different model and a different species. Here we investigated the effects of G-CSF in Wistar rats using the New York University Impactor. In this model, corroborating our previous data, rats treated subcutaneously with G-CSF over 2 weeks show significant improvement of motor function.

  14. Fish population modeling approaches for assessing direct effects and recovery following mitigation of a pulp mill effluent in Jackfish Bay

    Science.gov (United States)

    We present an approach to link chemically-induced alterations in molecular and biochemical endpoints to adverse outcomes in whole organisms and populations. A predictive population model was developed to translate changes in fecundity measures of white sucker (Catostomus commers...

  15. AIUB-CHAMP02S: The influence of GNSS model changes on gravity field recovery using spaceborne GPS

    Science.gov (United States)

    Prange, L.; Jäggi, A.; Dach, R.; Bock, H.; Beutler, G.; Mervart, L.

    2010-01-01

    The gravity field model AIUB-CHAMP02S, which is based on six years of CHAMP GPS data, is presented here. The gravity field parameters were derived using a two step procedure: In a first step a kinematic trajectory of a low Earth orbiting (LEO) satellite is computed using the GPS data from the on-board receiver. In this step the orbits and clock corrections of the GPS satellites as well as the Earth rotation parameters (ERPs) are introduced as known. In the second step this kinematic orbit is represented by a gravitational force model and orbit parameters. In order to ensure full model consistency the GPS satellite orbits and clock corrections, which have been used for the generation of the kinematic LEO trajectories, were taken from the Center for Orbit Determination in Europe (CODE), located at AIUB (Dach et al., 2009). In recent years many changes have taken place in the processing chain of global navigation satellite system (GNSS) data, e.g., the implementation of absolute antenna phase center modeling. Therefore a reprocessing of the GPS data to obtain state-of-the-art GPS satellite orbits and clock corrections was performed. From these updated GPS products new kinematic orbits of the CHAMP satellite were derived for the years 2002-2007. From the updated CHAMP trajectories spherical harmonic (SH) coefficients of the Earth’s gravity field were determined in exactly the same way as from the original LEO orbit. This allowed us to study the impact of the improved LEO orbits on the derived gravity field parameters and the generation of the multi-year gravity field model AIUB-CHAMP02S. The change of the IGS standards creates an inconsistency to existing global gravity field models, which mainly affects the zonal coefficients of low even degrees. The inconsistency is caused by the change to the absolute antenna phase center model and can be reduced by estimating the phase center variation of the CHAMP GPS antenna.

  16. Modelo para la Simulación en Estado Estable de Redes de Recuperación de Calor Model for Steady State Simulation of Heat Recovery Networks

    Directory of Open Access Journals (Sweden)

    M Picón-Núñez

    2004-01-01

    Full Text Available En este trabajo se desarrolla un modelo para la simulación en estado estable de redes de recuperación de calor considerando una sola fase. Se utilizan el modelo básico de la efectividad térmica y de las relaciones con el Número de Unidades de Transferencia de Calor para la simulación de la operación de intercambiadores de calor. La aplicación del modelo se demuestra en un caso de estudio tomado de la literatura donde se determinan las nuevas temperaturas de una red una vez que las perturbaciones de tipo flujo másico y temperatura entran al sistema. Se concluye que la simulación en estado estable desarrollada entrega resultados confiables.In this work, a model for the steady state simulation of heat recovery networks in single phase is developed. The basic model of the thermal effectiveness and its relation to the Number of Heat Transfer Units are used for the simulation of the operation of heat exchangers. The application of the model is demonstrated for a study case from the literature where network temperatures are calculated after perturbation to the flow rate and to the temperature are introduced into the system. It is concluded that the steady state simulation developed in this work gives reliable results.

  17. Numerical modelling of biophysicochemical effects on multispecies reactive transport in porous media involving Pseudomonas putida for potential microbial enhanced oil recovery application.

    Science.gov (United States)

    Sivasankar, P; Rajesh Kanna, A; Suresh Kumar, G; Gummadi, Sathyanarayana N

    2016-07-01

    pH and resident time of injected slug plays a critical role in characterizing the reservoir for potential microbial enhanced oil recovery (MEOR) application. To investigate MEOR processes, a multispecies (microbes-nutrients) reactive transport model in porous media was developed by coupling kinetic and transport model. The present work differs from earlier works by explicitly determining parametric values required for kinetic model by experimental investigations using Pseudomonas putida at different pH conditions and subsequently performing sensitivity analysis of pH, resident time and water saturation on concentrations of microbes, nutrients and biosurfactant within reservoir. The results suggest that nutrient utilization and biosurfactant production are found to be maximum at pH 8 and 7.5 respectively. It is also found that the sucrose and biosurfactant concentrations are highly sensitive to pH rather than reservoir microbial concentration, while at larger resident time and water saturation, the microbial and nutrient concentrations were lesser due to enhanced dispersion. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury.

    Science.gov (United States)

    Peng, Weijun; Sun, Jing; Sheng, Chenxia; Wang, Zhe; Wang, Yang; Zhang, Chunhu; Fan, Rong

    2015-03-26

    The therapeutic potential of mesenchymal stem cells (MSCs) for traumatic brain injury (TBI) is attractive. Conducting systematic review and meta-analyses based on data from animal studies can be used to inform clinical trial design. To conduct a systematic review and meta-analysis to (i) systematically review the literatures describing the effect of MSCs therapy in animal models of TBI, (ii) determine the estimated effect size of functional locomotor recovery after experimental TBI, and (iii) to provide empirical evidence of biological factors associated with greater efficacy. We conducted a systematic search of PubMed, EMBASE, and Web of Science and hand searched related references. Studies were selected if they reported the efficacy of MSCs in animal models of TBI. Two investigators independently assessed the identified studies. We extracted the details of individual study characteristics from each publication, assessed study quality, evaluated the effect sizes of MSCs treatment, and performed stratified meta-analysis and meta-regression, to assess the influence of study design on the estimated effect size. The presence of small effect sizes was investigated using funnel plots and Egger's tests. Twenty-eight eligible controlled studies were identified. The study quality was modest. Between-study heterogeneity was large. Meta-analysis showed that MSCs exert statistically significant positive effects on sensorimotor and neurological motor function. For sensorimotor function, maximum effect size in studies with a quality score of 5 was found in the weight-drop impact injury TBI model established in male SD rats, to which syngeneic umbilical cord-derived MSCs intracerebrally at cell dose of (1-5)×10(6) was administered r 6 hours following TBI, using ketamine as anesthetic agent. For neurological motor function, effect size was maximum for studies with a quality score of 5, in which the weight-drop impact injury TBI models of the female Wistar rats were adopted, with

  19. Toe out angle : a functional index for the evaluation of sciatic nerve recovery in the rat model

    NARCIS (Netherlands)

    Varejao, ASP; Cabrita, AM; Geuna, S; Melo-Pinto, P; Filipe, VM; Gramsbergen, A; Meek, MF

    2003-01-01

    In experimental peripheral nerve studies, the rat sciatic nerve model is widely used to examine functional outcome following nerve injury and repair. A variety of evaluation methods exist in the literature, but an adequate selection continues to be a critical point for the researcher. Rats with scia

  20. The Impact of Three Factors on the Recovery of Item Parameters for the Three-Parameter Logistic Model

    Science.gov (United States)

    Kim, Kyung Yong; Lee, Won-Chan

    2017-01-01

    This article provides a detailed description of three factors (specification of the ability distribution, numerical integration, and frame of reference for the item parameter estimates) that might affect the item parameter estimation of the three-parameter logistic model, and compares five item calibration methods, which are combinations of the…

  1. Tests Results of the Electrostatic Accelerometer Flight Models for Gravity Recovery and Climate Experiment Follow-On Mission (GRACE FO)

    Science.gov (United States)

    Perrot, E.; Boulanger, D.; Christophe, B.; Foulon, B.; Lebat, V.; Huynh, P. A.; Liorzou, F.

    2015-12-01

    The GRACE FO mission, led by the JPL (Jet Propulsion Laboratory), is an Earth-orbiting gravity mission, continuation of the GRACE mission, which will produce an accurate model of the Earth's gravity field variation providing global climatic data during five years at least. The mission involves two satellites in a loosely controlled tandem formation, with a micro-wave link measuring the inter-satellites distance variation. Earth's mass distribution non-uniformities cause variations of the inter-satellite distance. This variation is measured to recover gravity, after subtracting the non-gravitational contributors, as the residual drag. ONERA (the French Aerospace Lab) is developing, manufacturing and testing electrostatic accelerometers measuring this residual drag applied on the satellites. The accelerometer is composed of two main parts: the Sensor Unit (including the Sensor Unit Mechanics - SUM - and the Front-End Electronic Unit - FEEU) and the Interface Control Unit - ICU. In the Accelerometer Core, located in the Sensor Unit Mechanics, the proof mass is levitated and maintained at the center of an electrode cage by electrostatic forces. Thus, any drag acceleration applied on the satellite involves a variation on the servo-controlled electrostatic suspension of the mass. The voltage on the electrodes providing this electrostatic force is the output measurement of the accelerometer. The impact of the accelerometer defaults (geometry, electronic and parasitic forces) leads to bias, misalignment and scale factor error, non-linearity and noise. Some of these accelerometer defaults are characterized by tests with micro-gravity pendulum bench on ground and with drops in ZARM catapult. The Critical Design Review was achieved successfully on September 2014. The Engineering Model (EM) was integrated and tested successfully, with ground levitation, drops, Electromagnetic Compatibility and thermal vacuum. The integration of the two Flight Models was done on July 2015. The

  2. Assessment and validation of prognostic models for poor functional recovery 12 months after whiplash injury: a multicentre inception cohort study.

    Science.gov (United States)

    Sterling, Michele; Hendrikz, Joan; Kenardy, Justin; Kristjansson, Eythor; Dumas, Jean-Pierre; Niere, Ken; Cote, Julie; Deserres, Sophie; Rivest, Karine; Jull, Gwendolen

    2012-08-01

    Uncertainty surrounds prognostic factors after whiplash injury. Previously we identified a prognostic model for 6-month pain-related disability in a cohort of 80 participants with acute whiplash. Predictors included initial disability, older age, decreased cold pain thresholds, decreased neck rotation movement, posttraumatic stress symptoms and decreased sympathetic vasoconstriction. The objective of this study was to externally validate this model. In a multicentre inception cohort study, 286 participants with acute whiplash (I, II or III) were assessed at <3 weeks and 12 months after injury. The Neck Disability Index (NDI) was the outcome. Observed and predicted NDI scores were generated using the published equation of the original model. Model discrimination between participants with no or mild disability from those with moderate to severe disability was examined by receiver operating characteristic curves. Initial NDI and cold pain threshold predicted current observed 12-month NDI scores (r(2) = 0.50, 95% confidence interval 0.42 to 0.58). There was a significant site effect, and the estimated marginal mean ± SE of 12-month NDI for Iceland (27.6 ± 1.79%) was higher than the other 3 sites (Melbourne 11.2 ± 5.03%, Canada 16.4 ± 2.36%, Brisbane 16.8 ± 1.17%). After adjusting for site, age and Impact of Events Scale scores regained significance (r(2) = 0.56, 95% confidence interval 0.48 to 0.64). The tested model was not precise in predicting NDI as a continuous variable. However, it found good accuracy to discriminate participants with moderate to severe disability at 12 months (area under the receiver operating characteristic curve 0.89 [95% confidence interval 0.84-0.94], P<.001) which is clinically useful.

  3. A Recovery Rate Model under Stochastic Cash Flow%随机现金流下的违约回收率模型

    Institute of Scientific and Technical Information of China (English)

    巴曙松; 覃川桃; 朱元倩

    2009-01-01

    违约回收率是信用风险管理的基础变量,债务人的财务状况是影响违约回收率的重要因素之一.当公司遇到财务困难时现金流的不确定性非常高,本文利用连续时间资产定价理论,研究了债务人随机现金流情况下的违约回收率,违约回收率是公司现金流状况的内生变量.违约回收率与公司现金流压力,现金流漂移率,公司违约区间相对长度正相关,与现金流波动率负相关.用四川大额不良贷款数据验证了模型结果.%Recovery Rate (RR) is the basic variable of credit risk management, which is influenced by the financial situation of the obligor. The cash flow is uncertainty when a corporate is faced with financial distress. Based on continuous-time asset pricing theory, this paper develops a RR model under the assumption of stochastic cash flows, where RR is determined endogenously by the corporate finance structure. Under our assumptions, recovery rate is positively correlated with the company's cash flow pressure, cash flow drift rate and corporate default interval relative length, negatively correlated with cash flow volatility. The results are empirically tested with data on Sichuan large sum non-performing loans.

  4. EPA Recovery Mapper

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Recovery Mapper is an Internet interactive mapping application that allows users to discover information about every American Recovery and Reinvestment Act...

  5. Fasciotomy Reduces Compartment Pressures and Improves Recovery in a Porcine Model of Extremity Vascular Injury and Ischemia/Reperfusion

    Science.gov (United States)

    2012-10-01

    oxygen mixture of 40 to 60% by facemask until endotracheal intubation was performed. The animal was then placed in the supine position on the...operative day 14 the animals were endotracheally intubated prior to the studies being performed. Compartment Pressure Measurement Anterior...animal model revealed that a shunt placed in less than three hours from injury had a lower circulating ischemia index , with good shunt patency over

  6. Measurement and Modeling of Ecosystem Risk and Recovery for In Situ Treatment of Contaminated Sediments. Phase 3

    Science.gov (United States)

    2015-08-01

    Choi was supported in part by a Samsung Scholarship. Collaboration with Newcastle University was facilitated by the Leverhulme Trust, grant FOO 125/AA...consuming and expensive . No fast, inexpensive field methods currently exist to predict the bio-uptake of contaminants and explain post-treatment...generate additional cost for the users. Therefore, we develop an executable program of the HOC mass transfer model using MATLAB Compiler™ (http

  7. Indirect effects of recovery strategies

    DEFF Research Database (Denmark)

    Andersen, Ken Haste; Rice, Jake

    in isolation,but the expected consequences for the rest of the ecosystem must be analyzed. We use ageneral size- and trait-based model to calculate the ecosystem effects of fishing andrecovery. We present a general analysis of a recovery strategies targeting either large fishes(consumer fishery), small fishes...

  8. Youth in Recovery

    Science.gov (United States)

    de Miranda, John; Williams, Greg

    2011-01-01

    Young people are entering long-term recovery probably in greater numbers than ever before. A key word here is "probably" because we know precious little about the phenomenon of young people who recover from alcohol and drug addition. This article is a preliminary exploration of youth in recovery. It reviews several types of recovery support…

  9. Recovery from mental illness

    DEFF Research Database (Denmark)

    Petersen, Kirsten Schultz; Friis, Vivi Soegaard; Haxholm, Birthe Lodahl;

    2015-01-01

    Mental health services strive to implement a recovery-oriented approach to rehabilitation. Little is known about service users' perception of the recovery approach. The aim is to explore the service user's perspectives on facilitators and barriers associated with recovery. Twelve residents living...

  10. Technical Subtopic 2.1: Modeling Variable Refrigerant Flow Heat Pump and Heat Recovery Equipment in EnergyPlus

    Energy Technology Data Exchange (ETDEWEB)

    Raustad, Richard; Nigusse, Bereket; Domitrovic, Ron

    2013-09-30

    The University of Central Florida/Florida Solar Energy Center, in cooperation with the Electric Power Research Institute and several variable-refrigerant-flow heat pump (VRF HP) manufacturers, provided a detailed computer model for a VRF HP system in the United States Department of Energy's (U.S. DOE) EnergyPlus? building energy simulation tool. Detailed laboratory testing and field demonstrations were performed to measure equipment performance and compare this performance to both the manufacturer's data and that predicted by the use of this new model through computer simulation. The project goal was to investigate the complex interactions of VRF HP systems from an HVAC system perspective, and explore the operational characteristics of this HVAC system type within a laboratory and real world building environment. Detailed laboratory testing of this advanced HVAC system provided invaluable performance information which does not currently exist in the form required for proper analysis and modeling. This information will also be useful for developing and/or supporting test standards for VRF HP systems. Field testing VRF HP systems also provided performance and operational information pertaining to installation, system configuration, and operational controls. Information collected from both laboratory and field tests were then used to create and validate the VRF HP system computer model which, in turn, provides architects, engineers, and building owners the confidence necessary to accurately and reliably perform building energy simulations. This new VRF HP model is available in the current public release version of DOE?s EnergyPlus software and can be used to investigate building energy use in both new and existing building stock. The general laboratory testing did not use the AHRI Standard 1230 test procedure and instead used an approach designed to measure the field installed full-load operating performance. This projects test methodology used the air

  11. Technical Subtopic 2.1: Modeling Variable Refrigerant Flow Heat Pump and Heat Recovery Equipment in EnergyPlus

    Energy Technology Data Exchange (ETDEWEB)

    Raustad, Richard; Nigusse, Bereket; Domitrovic, Ron

    2013-09-30

    The University of Central Florida/Florida Solar Energy Center, in cooperation with the Electric Power Research Institute and several variable-refrigerant-flow heat pump (VRF HP) manufacturers, provided a detailed computer model for a VRF HP system in the United States Department of Energy's (U.S. DOE) EnergyPlus? building energy simulation tool. Detailed laboratory testing and field demonstrations were performed to measure equipment performance and compare this performance to both the manufacturer's data and that predicted by the use of this new model through computer simulation. The project goal was to investigate the complex interactions of VRF HP systems from an HVAC system perspective, and explore the operational characteristics of this HVAC system type within a laboratory and real world building environment. Detailed laboratory testing of this advanced HVAC system provided invaluable performance information which does not currently exist in the form required for proper analysis and modeling. This information will also be useful for developing and/or supporting test standards for VRF HP systems. Field testing VRF HP systems also provided performance and operational information pertaining to installation, system configuration, and operational controls. Information collected from both laboratory and field tests were then used to create and validate the VRF HP system computer model which, in turn, provides architects, engineers, and building owners the confidence necessary to accurately and reliably perform building energy simulations. This new VRF HP model is available in the current public release version of DOE?s EnergyPlus software and can be used to investigate building energy use in both new and existing building stock. The general laboratory testing did not use the AHRI Standard 1230 test procedure and instead used an approach designed to measure the field installed full-load operating performance. This projects test methodology used the air

  12. The Vessel Schedule Recovery Problem

    DEFF Research Database (Denmark)

    Brouer, Berit Dangaard; Plum, Christian Edinger Munk; Vaaben, Bo;

    Maritime transportation is the backbone of world trade and is accountable for around 3% of the worlds CO2 emissions. We present the Vessel Schedule Recovery Problem (VSRP) to evaluate a given disruption scenario and to select a recovery action balancing the trade off between increased bunker cons...... consumption and the impact on the remaining network and the customer service level. The model is applied to 4 real cases from Maersk Line. Solutions are comparable or superior to those chosen by operations managers. Cost savings of up to 58% may be achieved....

  13. X-ray diffraction analysis and metal physics modeling of static strain aging and thermal dislocation recovery in the mechanically affected zone of surface finished hardened steel

    Energy Technology Data Exchange (ETDEWEB)

    Gegner, Juergen [SKF GmbH, Dept. of Material Physics, Schweinfurt (Germany)

    2009-07-01

    After heat treatment, finish machining of the hardened steel represents the last manufacturing step of machine elements. The practically most important operation of grinding is applied to achieve edge zone compressive residual stresses, best surface quality and dimensional accuracy. Metal removal involves high plastic deformation work. Glide and intersection processes raise the density and produce lower energy substructures of dislocations. The temperature and time behavior of post-machining thermal treatment is analyzed on ground and honed martensitic SAE 52100 rolling bearing steel. Microstructure stabilization is reflected in a large XRD line width decrease on the surface. The kinetics is modeled by rate-controlling carbide dissolution as the carbon source for Cottrell-type segregation at dislocations. This static strain aging is verified by the formation of a slight white etching surface layer. The metal physics model is extended to also consider superimposed thermal dislocation recovery. Both effects are separable. In rolling contact fatigue tests under mixed friction running conditions, air reheating of the samples below the tempering temperature, which avoids hardness loss, leads to a significant lifetime increase. Thermal post-treatment after cold working results in similar changes of the XRD line width in the larger mechanically affected edge zone.

  14. Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model.

    Science.gov (United States)

    Chatterjee, Aparajita; Ratner, Daniel M; Ryan, Christopher M; Johnson, Patricia J; O'Keefe, Barry R; Secor, W Evan; Anderson, Deborah J; Robbins, Phillips W; Samuelson, John

    2015-01-01

    Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus causes premature abortion in cattle. Our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of HIV, on adherence of Trichomonas to ectocervical cells and on Tritrichomonas infections in a mouse model. We show that Trichomonas Asn-linked glycans (N-glycans), like those of HIV, bind the mannose-binding lectin (MBL) that is part of the innate immune system. N-glycans of Trichomonas and Tritrichomonas bind anti-retroviral lectins (cyanovirin-N and griffithsin) and the 2G12 monoclonal antibody, each of which binds HIV N-glycans. Binding of cyanovirin-N appears to be independent of susceptibility to metronidazole, the major drug used to treat Trichomonas. Anti-retroviral lectins, MBL, and galectin-1 cause Trichomonas to self-aggregate and precipitate. The anti-retroviral lectins also increase adherence of ricin-resistant mutants, which are less adherent than parent cells, to ectocervical cell monolayers and to organotypic EpiVaginal tissue cells. Topical application of either anti-retroviral lectins or yeast N-glycans decreases by 40 to 70% the recovery of Tritrichomonas from the mouse vagina. These results, which are explained by a few simple models, suggest that the anti-retroviral lectins have a modest potential for preventing or treating human infections with Trichomonas.

  15. Recovery and resilience after a nuclear power plant disaster: a medical decision model for managing an effective, timely, and balanced response.

    Science.gov (United States)

    Coleman, C Norman; Blumenthal, Daniel J; Casto, Charles A; Alfant, Michael; Simon, Steven L; Remick, Alan L; Gepford, Heather J; Bowman, Thomas; Telfer, Jana L; Blumenthal, Pamela M; Noska, Michael A

    2013-04-01

    Resilience after a nuclear power plant or other radiation emergency requires response and recovery activities that are appropriately safe, timely, effective, and well organized. Timely informed decisions must be made, and the logic behind them communicated during the evolution of the incident before the final outcome is known. Based on our experiences in Tokyo responding to the Fukushima Daiichi nuclear power plant crisis, we propose a real-time, medical decision model by which to make key health-related decisions that are central drivers to the overall incident management. Using this approach, on-site decision makers empowered to make interim decisions can act without undue delay using readily available and high-level scientific, medical, communication, and policy expertise. Ongoing assessment, consultation, and adaption to the changing conditions and additional information are additional key features. Given the central role of health and medical issues in all disasters, we propose that this medical decision model, which is compatible with the existing US National Response Framework structure, be considered for effective management of complex, large-scale, and large-consequence incidents.

  16. Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model.

    Directory of Open Access Journals (Sweden)

    Aparajita Chatterjee

    Full Text Available Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus causes premature abortion in cattle. Our goals were to determine the effects, if any, of anti-retroviral lectins, which are designed to prevent heterosexual transmission of HIV, on adherence of Trichomonas to ectocervical cells and on Tritrichomonas infections in a mouse model. We show that Trichomonas Asn-linked glycans (N-glycans, like those of HIV, bind the mannose-binding lectin (MBL that is part of the innate immune system. N-glycans of Trichomonas and Tritrichomonas bind anti-retroviral lectins (cyanovirin-N and griffithsin and the 2G12 monoclonal antibody, each of which binds HIV N-glycans. Binding of cyanovirin-N appears to be independent of susceptibility to metronidazole, the major drug used to treat Trichomonas. Anti-retroviral lectins, MBL, and galectin-1 cause Trichomonas to self-aggregate and precipitate. The anti-retroviral lectins also increase adherence of ricin-resistant mutants, which are less adherent than parent cells, to ectocervical cell monolayers and to organotypic EpiVaginal tissue cells. Topical application of either anti-retroviral lectins or yeast N-glycans decreases by 40 to 70% the recovery of Tritrichomonas from the mouse vagina. These results, which are explained by a few simple models, suggest that the anti-retroviral lectins have a modest potential for preventing or treating human infections with Trichomonas.

  17. Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer’s Mouse Model

    Science.gov (United States)

    Ceccom, Johnatan; Coslédan, Frédéric; Halley, Hélène; Francès, Bernard

    2012-01-01

    Alzheimer’s disease (AD) is a neurodegenerative syndrom involving many different biological parameters, including the accumulation of copper metal ions in Aβ amyloid peptides due to a perturbation of copper circulation and homeostasis within the brain. Copper-containing amyloids activated by endogenous reductants are able to generate an oxidative stress that is involved in the toxicity of abnormal amyloids and contribute to the progressive loss of neurons in AD. Since only few drugs are currently available for the treatment of AD, we decided to design small molecules able to interact with copper and we evaluated these drug-candidates with non-transgenic mice, since AD is mainly an aging disease, not related to genetic disorders. We created a memory deficit mouse model by a single icv injection of Aβ1–42 peptide, in order to mimic the early stage of the disease and the key role of amyloid oligomers in AD. No memory deficit was observed in the control mice with the antisense Aβ42-1 peptide. Here we report the capacity of a new copper-specific chelating agent, a bis-8-aminoquinoline PA1637, to fully reverse the deficit of episodic memory after three weeks of treatment by oral route on non-transgenic amyloid-impaired mice. Clioquinol and memantine have been used as comparators to validate this fast and efficient mouse model. PMID:22927947

  18. ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation

    Directory of Open Access Journals (Sweden)

    Tina Zimmermann

    2016-10-01

    Full Text Available Huntington's disease (HD is characterized by fatal motoric failures induced by loss of striatal medium spiny neurons. Neuronal cell death has been linked to impaired expression and axonal transport of the neurotrophin BDNF (brain-derived neurotrophic factor. By transplanting embryonic stem cell-derived neural progenitors overexpressing BDNF, we combined cell replacement and BDNF supply as a potential HD therapy approach. Transplantation of purified neural progenitors was analyzed in a quinolinic acid (QA chemical and two genetic HD mouse models (R6/2 and N171-82Q on the basis of distinct behavioral parameters, including CatWalk gait analysis. Explicit rescue of motor function by BDNF neural progenitors was found in QA-lesioned mice, whereas genetic mouse models displayed only minor improvements. Tumor formation was absent, and regeneration was attributed to enhanced neuronal and striatal differentiation. In addition, adult neurogenesis was preserved in a BDNF-dependent manner. Our findings provide significant insight for establishing therapeutic strategies for HD to ameliorate neurodegenerative symptoms.

  19. Clean recovery of antioxidant compounds from plant foods, by-products and algae assisted by ultrasounds processing. Modeling approaches to optimize processing conditions

    DEFF Research Database (Denmark)

    Roselló-Soto, Elena; Galanakis, Charis M.; Brnčić, Mladen;

    2015-01-01

    Ultrasound treatment is an alternative affordable, effective and reproducible method for the improved recovery of bioactive compounds from various processing streams. The objective of this review is to discuss the impact of ultrasound-assisted extraction on the recovery of polyphenols, carotenoids...

  20. The nonlinear effect of somatic cell count on milk composition, coagulation properties, curd firmness modeling, cheese yield, and curd nutrient recovery.

    Science.gov (United States)

    Bobbo, T; Cipolat-Gotet, C; Bittante, G; Cecchinato, A

    2016-07-01

    The aim of this study was to investigate the relationships between somatic cell count (SCC) in milk and several milk technological traits at the individual cow level. In particular, we determined the effects of very low to very high SCC on traits related to (1) milk yield and composition; (2) coagulation properties, including the traditional milk coagulation properties (MCP) and the new curd firming model parameters; and (3) cheese yield and recovery of milk nutrients in the curd (or loss in the whey). Milk samples from 1,271 Brown Swiss cows from 85 herds were used. Nine coagulation traits were measured: 3 traditional MCP [rennet coagulation time (RCT, min), curd firming rate (k20, min), and curd firmness after 30 min (a30, mm)] and 6 new curd firming and syneresis traits [potential asymptotic curd firmness at infinite time (CFP, mm), curd firming instant rate constant (kCF, % × min(-1)), syneresis instant rate constant (kSR, % × min(-1)), rennet coagulation time estimated using the equation (RCTeq, min), maximum curd firmness achieved within 45 min (CFmax, mm), and time at achievement of CFmax (tmax, min)]. The observed cheese-making traits included 3 cheese yield traits (%CYCURD, %CYSOLIDS, and %CYWATER, which represented the weights of curd, total solids, and water, respectively, as a percentage of the weight of the processed milk) and 4 nutrient recoveries in the curd (RECFAT, RECPROTEIN, RECSOLIDS, and RECENERGY, which each represented the percentage ratio between the nutrient in the curd and milk). Data were analyzed using a linear mixed model with the fixed effects of days in milk, parity, and somatic cell score (SCS), and the random effect of herd-date. Somatic cell score had strong influences on casein number and lactose, and also affected pH; these were traits characterized by a quadratic pattern of the data. The results also showed a negative linear relationship between SCS and milk yield. Somatic cell score influenced almost all of the tested

  1. Axial Vibration Analysis of the Mud Recovery Line on Deepwater Riserless Mud Recovery Drilling System

    Institute of Scientific and Technical Information of China (English)

    王国栋; 陈国明; 许亮斌; 殷志明

    2014-01-01

    The series connection of multistage pumping module is the common concept of deepwater riserless mud recovery drilling system. In this system, the influence of the mass of pumping module on the vibration of mud recovery line cannot be ignored, and the lumped mass method has been utilized to discretize the mud recovery line. Based on the analysis of different boundary conditions, the paper establishes the axial forced vibration model of the mud recovery line considering the seawater damping, and the vibration model analysis provides the universal solution to the vibration model. An example of the two-stage pumping system has been used to analyze the dynamic response of mud recovery line under different excited frequencies. This paper has the important directive significance for the application of riserless mud recovery drilling technology in deepwater surface drilling.

  2. The existential way to recovery.

    Science.gov (United States)

    Moore, Laurie Jo; Goldner-Vukov, Mila

    2009-12-01

    This paper explores the essential features of recovery and the need for an existential approach in psychiatry. The biopsychosocial model often fails to sufficiently validate the existential suffering of patients. We review the major principles of recovery and the philosophical and psychiatric principles of existentialism. The ontological or intrinsic existential issues of death, isolation, freedom and meaninglessness are described and their manifestations are explored in clinical syndromes. When ultimate existential concerns are recognised, patients have an opportunity to understand their life on a deeper level that is not defined as a medical disorder but as a part of human existence. Understanding that existential concerns underlie a great deal of human behaviour helps to free patients from the stigma of psychiatric labels. An existential approach is a humanistic way toward recovery.

  3. Identifying optimal sites for natural recovery and restoration of impacted biogenic habitats in a special area of conservation using hydrodynamic and habitat suitability modelling

    Science.gov (United States)

    Elsäßer, Björn; Fariñas-Franco, Jose M.; Wilson, Conor David; Kregting, Louise; Roberts, Dai

    2013-03-01

    Selection of sites for successful restoration of impacted shellfish populations depends on understanding the dispersion capability and habitat requirements of the species involved. In Strangford Lough, Northern Ireland, the horse mussel (Modiolus modiolus) biogenic reefs cover only a fraction of their historical range with the remaining reefs badly damaged and requiring restoration. Previous experimental trials suggest that translocation of horse mussels accelerates reef recovery and has therefore been proposed as a suitable restoration technique. We used a series of coupled hydrodynamic and particle dispersal models to assess larval dispersion from remnant and translocated populations to identify suitable areas for adult live M. modiolus translocation in Strangford Lough, Northern Ireland. A maximum entropy model (MAXENT) was used to identify if dispersing larvae could reach habitat suitable for adult M. modiolus. From these we predicted if translocated mussels will reseed themselves or be able to act as larval sources for nearby reefs. The dispersal models showed that the remnant M. modiolus populations are largely self-recruiting with little connectivity between them. The majority of larvae settled near the sources and movement was largely dependent on the tides and not influenced by wind or waves. Higher reef elevation resulted in larvae being able to disperse further away from the release point. However, larval numbers away from the source population are likely to be too low for successful recruitment. There was also little connectivity between the Irish Sea and Strangford Lough as any larvae entering the Lough remained predominantly in the Strangford Narrows. The areas covered by these self-seeding populations are suitable for M. modiolus translocation according to the MAXENT model. As a result of this work and in conjunction with other field work we propose a combination of total protection of all remaining larval sources and small scale translocations onto

  4. Using an Informative Missing Data Model to Predict the Ability to Assess Recovery of Balance Control after Spaceflight

    Science.gov (United States)

    Feiveson, Alan H.; Wood, Scott J.; Jain, Varsha

    2008-01-01

    Astronauts show degraded balance control immediately after spaceflight. To assess this change, astronauts' ability to maintain a fixed stance under several challenging stimuli on a movable platform is quantified by "equilibrium" scores (EQs) on a scale of 0 to 100, where 100 represents perfect control (sway angle of 0) and 0 represents data loss where no sway angle is observed because the subject has to be restrained from falling. By comparing post- to pre-flight EQs for actual astronauts vs. controls, we built a classifier for deciding when an astronaut has recovered. Future diagnostic performance depends both on the sampling distribution of the classifier as well as the distribution of its input data. Taking this into consideration, we constructed a predictive ROC by simulation after modeling P(EQ = 0) in terms of a latent EQ-like beta-distributed random variable with random effects.

  5. Battleground Energy Recovery Project

    Energy Technology Data Exchange (ETDEWEB)

    Bullock, Daniel [USDOE Gulf Coast Clean Energy Application Center, Woodlands, TX (United States)

    2011-12-31

    In October 2009, the project partners began a 36-month effort to develop an innovative, commercial-scale demonstration project incorporating state-of-the-art waste heat recovery technology at Clean Harbors, Inc., a large hazardous waste incinerator site located in Deer Park, Texas. With financial support provided by the U.S. Department of Energy, the Battleground Energy Recovery Project was launched to advance waste heat recovery solutions into the hazardous waste incineration market, an area that has seen little adoption of heat recovery in the United States. The goal of the project was to accelerate the use of energy-efficient, waste heat recovery technology as an alternative means to produce steam for industrial processes. The project had three main engineering and business objectives: Prove Feasibility of Waste Heat Recovery Technology at a Hazardous Waste Incinerator Complex; Provide Low-cost Steam to a Major Polypropylene Plant Using Waste Heat; and Create a Showcase Waste Heat Recovery Demonstration Project.

  6. Amidated and ibuprofen-conjugated kyotorphins promote neuronal rescue and memory recovery in cerebral hypoperfusion dementia model

    Directory of Open Access Journals (Sweden)

    Sónia eSá Santos

    2016-01-01

    Full Text Available Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer’s disease (AD. In rats, permanent bilateral common carotid artery occlusion (2VO causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP is an endogenous antinociceptive dipeptide whose role as neuromodulator/neuroprotector has been suggested. Recently, we designed two analgesic KTP-derivatives, KTP-amide (KTP-NH2 and KTP-NH2 linked to ibuprofen (IbKTP-NH2 to improve KTP brain targeting. This study investigated the effects of KTP-derivatives on cognitive/behavioral functions (motor/spatial memory/nociception and hippocampal pathology of female rats in chronic cerebral hypoperfusion (2VO-rat model. 2VO-animals were treated with KTP-NH2 or IbKTP-NH2 for 7 days at weeks 2 and 5 post-surgery. After behavioral testing (week 6, coronal sections of hippocampus were H&E-stained or immunolabeled for the cellular markers GFAP (astrocytes and NFL (neurons. Our findings show that KTP-derivatives, mainly IbKTP-NH2, enhanced cognitive impairment of 2VO-animals and prevented neuronal damage in hippocampal CA1 subfield, suggesting their potential usefulness for the treatment of dementia.

  7. Modelling the Influence of Climate on the Performance of the Organic Rankine Cycle for Industrial Waste Heat Recovery

    Directory of Open Access Journals (Sweden)

    Ivan Korolija

    2016-05-01

    Full Text Available This paper describes a study of the relative influences of different system design decisions upon the performance of an organic Rankine cycle (ORC used to generate electricity from foundry waste heat. The design choices included concern the working fluid, whether to use a regenerator and the type of condenser. The novelty of the research lies in its inclusion of the influence of both the ORC location and the auxiliary electricity used by the pumps and fans in the ORC power system. Working fluids suitable for high temperature applications are compared, including three cyclic siloxanes, four linear siloxanes and three aromatic fluids. The ORC is modelled from first principles and simulation runs carried out using weather data for 106 European locations and a heat input profile that was derived from empirical data. The impact of design decisions upon ORC nominal efficiency is reported followed by the impact upon annual system efficiency in which variations in heat input and the condition of outdoor air over a year are considered. The main conclusion is that the location can have a significant impact upon the efficiency of ORC systems due to the influence of climate upon the condenser and auxiliary electricity requirements.

  8. Anomalous surface heave induced by enhanced oil recovery in northern Alberta: InSAR observations and numerical modeling

    Science.gov (United States)

    Pearse, Jill; Singhroy, Vern; Samsonov, Sergey; Li, Junhua

    2014-08-01

    Recent interferometric synthetic aperture radar observations over northern Alberta, Canada, show persistent surface heave occurring at rates of 1-4 cm/yr, localized at sites where the steam-assisted gravity drainage technique is currently used to extract bitumen from the Athabasca oil sands. We find that uplift rates above the horizontal injector wells are strongly correlated with rates of steam injection, even though there is a net fluid loss from the reservoir pore space as oil and water are withdrawn through the production wells. In combination with available steam injection and bitumen production data at four sites, we use reservoir flow models to explain how the thermal and geomechanical effects of steam injection on an oil sand reservoir can generate uplift at the surface. Results of our numerical experiments show that persistent surface heave consistent with observed rates can be driven by stress changes in the reservoir due to porous flow and thermal expansion. We also observe an unexpected localized uplift, of magnitude equal to or greater than the heave above the sites of steaming but located at clusters of wellheads which are outside the region of influence of the steam chambers. We show that this "wellhead" deformation can be explained by thermal expansion of rock near the injector wells.

  9. Factors affecting variation of different measures of cheese yield and milk nutrient recovery from an individual model cheese-manufacturing process.

    Science.gov (United States)

    Cipolat-Gotet, C; Cecchinato, A; De Marchi, M; Bittante, G

    2013-01-01

    Cheese yield (CY) is the most important technological trait of milk, because cheese-making uses a very high proportion of the milk produced worldwide. Few studies have been carried out at the level of individual milk-producing animals due to a scarcity of appropriate procedures for model-cheese production, the complexity of cheese-making, and the frequent use of the fat and protein (or casein) contents of milk as a proxy for cheese yield. Here, we report a high-throughput cheese manufacturing process that mimics all phases of cheese-making, uses 1.5-L samples of milk from individual animals, and allows the simultaneous processing of 15 samples per run. Milk samples were heated (35°C for 40 min), inoculated with starter culture (90 min), mixed with rennet (51.2 international milk-clotting units/L of milk), and recorded for gelation time. Curds were cut twice (10 and 15 min after gelation), separated from the whey, drained (for 30 min), pressed (3 times, 20 min each, with the wheel turned each time), salted in brine (for 60 min), weighed, and sampled. Whey was collected, weighed, and sampled. Milk, curd, and whey samples were analyzed for pH, total solids, fat content, and protein content, and energy content was estimated. Three measures of percentage cheese yield (%CY) were calculated: %CY(CURD), %CY(SOLIDS), and %CY(WATER), representing the ratios between the weight of fresh curd, the total solids of the curd, and the water content of the curd, respectively, and the weight of the milk processed. In addition, 3 measures of daily cheese yield (dCY, kg/d) were defined, considering the daily milk yield. Three measures of nutrient recovery (REC) were computed: REC(FAT), REC(PROTEIN), and REC(SOLIDS), which represented the ratio between the weights of the fat, protein, and total solids in the curd, respectively, and the corresponding components in the milk. Energy recovery, REC(ENERGY), represented the energy content of the cheese compared with that in the milk. This

  10. Visualization of TCE recovery mechanisms using surfactant-polymer solutions in a two-dimensional heterogeneous sand model.

    Science.gov (United States)

    Robert, Thomas; Martel, Richard; Conrad, Stephen H; Lefebvre, René; Gabriel, Uta

    2006-06-30

    This research focused on the optimization of TCE dissolution in a physical two-dimensional model providing a realistic representation of a heterogeneous granular aquifer. TCE was infiltrated in the sand pack where it resided both in pools and in zones of residual saturation. Surfactant was initially injected at low concentration to minimize TCE remobilization at first contact but was incrementally increased later during the experiment. Xanthan gum was added to the injected surfactant solution to optimize the sweep efficiency through the heterogeneous medium. Photographs and digital image analysis illustrated the interactions between TCE and the injected fluids. During the polymer flood, the effects of heterogeneities inside the sand pack were greatly reduced by the increased fluid viscosity and the shear-thinning effects of the polymer. The polymer also improved the contact between the TCE ganglia and the surfactant-polymer solution, thereby promoting dissolution. Surfactants interacted with the polymer reducing the overall viscosity of the solution. At first contact with a 0.5%(mass) surfactant solution, the TCE pools drained and some remobilization occurred. However, no TCE bank was formed and TCE did not penetrate into any previously uncontaminated areas. As a result, TCE surface area was increased. Subsequent surfactant floods at higher surfactant concentrations did not trigger more remobilization. TCE was mainly dissolved by the solution with the highest surfactant concentration. Plugging from bacterial growth or microgel formation associated to the polymer at the inflow screen prevented the full completion of the experiment. However, more than 90% of TCE was recovered with the circulation of less than 6 pore volumes of surfactant-polymer solution.

  11. Low-Level Laser Irradiation Improves Functional Recovery and Nerve Regeneration in Sciatic Nerve Crush Rat Injury Model

    Science.gov (United States)

    Wang, Chau-Zen; Chen, Yi-Jen; Wang, Yan-Hsiung; Yeh, Ming-Long; Huang, Mao-Hsiung; Ho, Mei-Ling; Liang, Jen-I; Chen, Chia-Hsin

    2014-01-01

    The development of noninvasive approaches to facilitate the regeneration of post-traumatic nerve injury is important for clinical rehabilitation. In this study, we investigated the effective dose of noninvasive 808-nm low-level laser therapy (LLLT) on sciatic nerve crush rat injury model. Thirty-six male Sprague Dawley rats were divided into 6 experimental groups: a normal group with or without 808-nm LLLT at 8 J/cm2 and a sciatic nerve crush injury group with or without 808-nm LLLT at 3, 8 or 15 J/cm2. Rats were given consecutive transcutaneous LLLT at the crush site and sacrificed 20 days after the crush injury. Functional assessments of nerve regeneration were analyzed using the sciatic functional index (SFI) and hindlimb range of motion (ROM). Nerve regeneration was investigated by measuring the myelin sheath thickness of the sciatic nerve using transmission electron microscopy (TEM) and by analyzing the expression of growth-associated protein 43 (GAP43) in sciatic nerve using western blot and immunofluorescence staining. We found that sciatic-injured rats that were irradiated with LLLT at both 3 and 8 J/cm2 had significantly improved SFI but that a significant improvement of ROM was only found in rats with LLLT at 8 J/cm2. Furthermore, the myelin sheath thickness and GAP43 expression levels were significantly enhanced in sciatic nerve-crushed rats receiving 808-nm LLLT at 3 and 8 J/cm2. Taken together, these results suggest that 808-nm LLLT at a low energy density (3 J/cm2 and 8 J/cm2) is capable of enhancing sciatic nerve regeneration following a crush injury. PMID:25119457

  12. 4D reservoir characterization using well log data for feasible CO2-enhanced oil recovery at Ankleshwar, Cambay Basin - A rock physics diagnostic and modeling approach

    Science.gov (United States)

    Ganguli, Shib Sankar; Vedanti, Nimisha; Dimri, V. P.

    2016-12-01

    In recent years, rock physics modeling has become an integral part of reservoir characterization as it provides the fundamental relationship between geophysical measurements and reservoir rock properties. These models are also used to quantify the effect of fluid saturation and stress on reservoir rocks by tracking the changes in elastic properties during production. Additionally, various rock physics models can be applied to obtain the information of rock properties away from existing drilled wells, which can play a crucial role in the feasibility assessment of CO2-enhanced oil recovery (EOR) operation at field. Thus, the objective of this study is to develop a rock-physics model of the Ankleshwar reservoir to predict the reservoir response under CO2-EOR. The Ankleshwar oil field is a mature field situated in Cambay Basin (Western India) that witnessed massive peripheral water flooding for around 40 years. Since the field was under water flooding for a long term, reasonable changes in reservoir elastic properties might have occurred. To identify potential reservoir zone with significant bypassed (or residual) oil saturation, we applied the diagnostic rock physics models to two available wells from the Ankleshwar oil field. The results clearly indicate transitions from clean sands to shaly sands at the base, and from sandy shale to pure shale at the top of the reservoir pay zone, suggesting a different seismic response at the top when compared to the base of the reservoir in both the wells. We also found that clay content and sorting affects the elastic properties of these sands, indicating different depositional scenario for the oil sands encountered in the Ankleshwar formation. Nevertheless, the rock physics template (RPT) analysis of the well data provides valuable information about the residual oil zone, a potential target for CO2-EOR. Further, a 4D reservoir characterization study has been conducted to assess the seismic detectability of CO2-EOR, and we

  13. Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats

    Science.gov (United States)

    Wang, Ping-Hui; Yang, Cheng-Chang; Su, Wei-Ren; Wu, Po-Ting; Cheng, Shun-Chien; Jou, I-Ming

    2017-01-01

    Purpose To determine susceptibility to decompression surgery in diabetic and nondiabetic peripheral neuropathy using a chronic compression neuropathy model. Materials and methods Twenty-four streptozotocin-induced diabetic rats were randomly divided into three groups: group I, chronic compression of the left sciatic nerve for 4 weeks with decompression; group II, similar without decompression; and group III, sham exposing the sciatic nerve only. The other 24 nondiabetic rats were assigned to groups IV–VI, which received compression–decompression, compression, and the sham operation, respectively. Mixed-nerve-elicited somatosensory evoked potentials (M-SSEPs) and compound muscle action potentials (CMAPs) were measured to verify the compression neuropathy in the posttreatment follow-up. Behavioral observations in thermal hyperalgesia tests were quantified before electrophysiologic examinations. Treated and contralateral nerves were harvested for histomorphologic analysis. Results Chronic compression of sciatic nerve induced significant reduction of amplitude and increment of latency of M-SSEP and CMAP in both diabetic and nondiabetic rats. Diabetic group changes were more susceptible. Decompression surgery significantly improved both sensory and motor conduction, thermal hyperalgesia, and the mean myelin diameter of the rat sciatic nerve in both diabetic and nondiabetic groups. Near full recovery of motor and sensory function occurred in the nondiabetic rats, but not in the diabetic rats 8 weeks postdecompression. Conclusion Behavioral, electrophysiologic, and histomorphologic findings indicate that decompression surgery is effective in both diabetic and nondiabetic peripheral neuropathy.

  14. Consumer providers' experiences of recovery and concerns as members of a psychiatric multidisciplinary outreach team: A qualitative descriptive study from the Japan Outreach Model Project 2011-2014

    Science.gov (United States)

    2017-01-01

    Objective The objective of this study was to clarify consumer providers (CPs) subjective experiences as members of a psychiatric multidisciplinary outreach team that provided services to individuals with a mental illness living in the community. Methods A qualitative descriptive study was conducted through semi-structured interviews. Participants were clients hired as CPs in the Japanese Outreach Model Project from September 2011 until March 2014. Of the seventeen CPs, nine participated in this study. We looked at the CPs' subjective experiences of fulfillment and difficulty. Results In the process of providing services, CPs experienced both achievements and concerns. They had a sense of achievement by caring for their clients and they experienced that they themselves were recovering. They were also concerned about having inadequate knowledge and skills to provide psychiatric services to their clients. Further, there were concerns about their dual role on the multidisciplinary team and being support staff while they were still using mental health services themselves. Conclusion The results show that the activities of CPs included fulfillment, recovery, and dilemmas. Clarifications will likely contribute to an increase in understanding and cooperation between CPs and other professionals with whom they work. Further studies are needed to investigate policies related to mental health consumers who are also providers of mental health services. PMID:28257462

  15. Recovery and money management.

    Science.gov (United States)

    Rowe, Michael; Serowik, Kristin L; Ablondi, Karen; Wilber, Charles; Rosen, Marc I

    2013-06-01

    Social recovery and external money management are important approaches in contemporary mental health care, but little research has been done on the relationship between the two or on application of recovery principles to money management for people at risk of being assigned a representative payee or conservator. Out of 49 total qualitative interviews, 25 transcripts with persons receiving Social Security insurance or Social Security disability insurance who were at risk of being assigned a money manager were analyzed to assess the presence of recognized recovery themes. The recovery principles of self-direction and responsibility were strong themes in participant comments related to money management. Money management interventions should incorporate peoples' recovery-related motivations to acquire financial management skills as a means to direct and assume responsibility for one's finances. Staff involved in money management should receive training to support client's recovery-related goals. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  16. Terrestrial ecosystem recovery - Modelling the effects of reduced acidic inputs and increased inputs of sea-salts induced by global change

    DEFF Research Database (Denmark)

    Beier, C.; Moldan, F.; Wright, R.F.

    2003-01-01

    to 3 large-scale "clean rain" experiments, the so-called roof experiments at Risdalsheia, Norway; Gardsjon, Sweden, and Klosterhede, Denmark. Implementation of the Gothenburg protocol will initiate recovery of the soils at all 3 sites by rebuilding base saturation. The rate of recovery is small...... and base saturation increases less than 5% over the next 30 years. A climate-induced increase in storm severity will increase the sea-salt input to the ecosystems. This will provide additional base cations to the soils and more than double the rate of the recovery, but also lead to strong acid pulses...... following high sea-salt inputs as the deposited base cations exchange with the acidity stored in the soil. Future recovery of soils and runoff at acidified catchments will thus depend on the amount and rate of reduction of acid deposition, and in the case of systems near the coast, the frequency...

  17. Beyond enhanced recovery?

    DEFF Research Database (Denmark)

    Jørgensen, Christoffer C; Kehlet, Henrik

    2014-01-01

    We read with great interest the special article by Smart and Daniels discussing several important topics of perioperative care, especially regarding lack of consensus on the definition of "postoperative recovery", and need for further understanding of the pathogenic mechanisms. However, we disagr...... that a "new, clearly defined standard of what "recovery" actually is", demands "a look beyond enhanced recovery"(1) for several reasons. This article is protected by copyright. All rights reserved....

  18. Using particle dispersal models to assist in the conservation and recovery of the overexploited native oyster (Ostrea edulis) in an enclosed sea lough

    Science.gov (United States)

    Smyth, David; Kregting, Louise; Elsäßer, Björn; Kennedy, Richard; Roberts, Dai

    2016-02-01

    Oyster populations around the world have seen catastrophic decline which has been largely attributed to overexploitation, disease and pollution. While considerable effort and resources have been implemented into restoring these important environmental engineers, the success of oyster populations is often limited by poor understanding of site-specific dispersal patterns of propagules. Water-borne transport is a key factor controlling or regulating the dispersal of the larval stage of benthic marine invertebrates which have limited mobility. The distribution of the native oyster Ostrea edulis in Strangford Lough, Northern Ireland, together with their densities and population structure at subtidal and intertidal sites has been documented at irregular intervals between 1997 and 2013. This paper revisits this historical data and considers whether different prevailing environmental conditions can be used to explain the distribution, densities and population structure of O. edulis in Strangford Lough. The approach adopted involved comparing predictive 2D hydrodynamic models coupled with particle tracking to simulate the dispersal of oyster larvae with historical and recent field records of the distribution of both subtidal and intertidal, populations since 1995. Results from the models support the hypothesis that commercial stocks of O. edulis introduced into Strangford Lough in the 1990s resulted in the re-establishment of wild populations of oysters in the Northern Basin which in turn provided a potential source of propagules for subtidal populations. These results highlight that strategic site selection (while inadvertent in the case of the introduced population in 1995) for the re-introduction of important shellfish species can significantly accelerate their recovery and restoration.

  19. Microvesicles but Not Exosomes from Pathfinder Cells Stimulate Functional Recovery of the Pancreas in a Mouse Streptozotocin-Induced Diabetes Model.

    Science.gov (United States)

    McGuinness, Dagmara; Anthony, Diana F; Moulisova, Vladimira; MacDonald, Alasdair I; MacIntyre, Alan; Thomson, Jacqueline; Nag, Abhijeet; Davies, R Wayne; Shiels, Paul G

    2016-06-01

    Pathfinder cells (PCs), a novel cell type derived from the pancreas of adult rats, have been demonstrated to stimulate recovery of tissue structure and function in two animal models of acute tissue damage to date-streptozotocin (STZ)-induced diabetes and ischemia-reperfusion damage to the kidney. In repaired tissue, PCs and their progeny typically represent only 0.02% of the repaired tissue, suggesting that they act via a paracrine mechanism on native cells in the damaged area. Extracellular vesicles are strong candidates for mediating such a paracrine effect. Therefore, we studied the effects of two PC-derived extracellular vesicle fractions on tissue repair in the STZ diabetes model, one containing primarily microvesicles and the second containing predominantly exosomes. Treatment of STZ-induced diabetic mice with the microvesicles preparation led to blood glucose, insulin, glucagon, and C-peptide levels similar to those found with PC treatment. Furthermore, analysis of the histopathology of the pancreas indicated islet regeneration. In contrast, the exosome fraction demonstrated no repair activity, and STZ diabetic mice treated with exosome preparations had blood glucose values that were indistinguishable from those of vehicle-only treated controls. Therefore, we conclude that exosomes play no part in PC action as detected by this assay, whereas microvesicles provide all or a large component of the paracrine activity of PCs. Because they act to stimulate repair of multiple tissues, PC-derived microvesicles may similarly have the potential to stimulate repair of many damaged tissues, identifying a very significant cell-free therapeutic opportunity in regenerative medicine.

  20. Further development of recovery boiler; Soodakattilan kehitystyoe

    Energy Technology Data Exchange (ETDEWEB)

    Janka, K.; Siiskonen, P.; Sundstroem, K. [Tampella Power Oy, Tampere (Finland)] [and others

    1996-12-01

    The global model of a recovery boiler was further developed. The aim is to be able to model the velocity, temperature and concentration fields in a boiler. At this moment the model includes submodels for: droplet drying, pyrolysis, char burning, gas burning and for droplet trajectory. The preliminary study of NO{sub x} and fly ash behaviour in a boiler was carried out. The study concerning flow field in the superheater area was carried out a 2-dimensional case in which the inflow parameters were taken from global model of a recovery boiler. Further the prediction methods of fouling in a recovery boiler were developed based on theoretical calculations of smelting behaviour of multicomponent mixtures and measurements at operating recovery boilers. (author)

  1. High-Speed Wind-Tunnel Tests of a Model of the Lockheed YP-80A Airplane Including Correlation with Flight Tests and Tests of Dive-Recovery Flaps

    Science.gov (United States)

    Cleary, Joseph W.; Gray, Lyle J.

    1947-01-01

    This report contains the results of tests of a 1/3-scale model of the Lockheed YP-90A "Shooting Star" airplane and a comparison of drag, maximum lift coefficient, and elevator angle required for level flight as measured in the wind tunnel and in flight. Included in the report are the general aerodynamic characteristics of the model and of two types of dive-recovery flaps, one at several positions along the chord on the lower surface of the wing and the other on the lower surface of the fuselage. The results show good agreement between the flight and wind-tunnel measurements at all Mach numbers. The results indicate that the YP-80A is controllable in pitch by the elevators to a Mach number of at least 0.85. The fuselage dive-recovery flaps are effective for producing a climbing moment and increasing the drag at Mach numbers up to at least 0.8. The wing dive-recovery flaps are most effective for producing a climbing moment at 0.75 Mach number. At 0.85 Mach number, their effectiveness is approximately 50 percent of the maximum. The optimum position for the wing dive-recovery flaps to produce a climbing moment is at approximately 35 percent of the chord.

  2. Selective recovery of dissolved Fe, Al, Cu, and Zn in acid mine drainage based on modeling to predict precipitation pH.

    Science.gov (United States)

    Park, Sang-Min; Yoo, Jong-Chan; Ji, Sang-Woo; Yang, Jung-Seok; Baek, Kitae

    2015-02-01

    Mining activities have caused serious environmental problems including acid mine drainage (AMD), the dispersion of mine tailings and dust, and extensive mine waste. In particular, AMD contaminates soil and water downstream of mines and generally contains mainly valuable metals such as Cu, Zn, and Ni as well as Fe and Al. In this study, we investigated the selective recovery of Fe, Al, Cu, Zn, and Ni from AMD. First, the speciation of Fe, Al, Cu, Zn, and Ni as a function of the equilibrium solution pH was simulated by Visual MINTEQ. Based on the simulation results, the predicted pHs for the selective precipitation of Fe, Al, Cu, and Zn/Ni were determined. And recovery yield of metals using simulation is over 99 %. Experiments using artificial AMD based on the simulation results confirmed the selective recovery of Fe, Al, Cu, and Zn/Ni, and the recovery yields of Fe/Al/Cu/Zn and Fe/Al/Cu/Ni mixtures using Na2CO3 were 99.6/86.8/71.9/77.0 % and 99.2/85.7/73.3/86.1 %, respectively. After then, the simulation results were applied to an actual AMD for the selective recovery of metals, and the recovery yields of Fe, Al, Cu, and Zn using NaOH were 97.2, 74.9, 66.9, and 89.7 %, respectively. Based on the results, it was concluded that selective recovery of dissolved metals from AMD is possible by adjusting the solution pH using NaOH or Na2CO3 as neutralizing agents.

  3. Computational non-chemically equilibrium model on the current zero simulation in a model N2 circuit breaker under the free recovery condition

    Science.gov (United States)

    Sun, Hao; Tanaka, Yasunori; Tomita, Kentaro; Wu, Yi; Rong, Mingzhe; Uesugi, Yoshihiko; Ishijima, Tatsuo

    2016-02-01

    A non-chemically equilibrium (non-CE) model was established to investigate the N2 arc plasma in the decaying phase during the arc interruption, and was validated by comparison with the experimental results based on laser Thomson scattering. Unlike the conventional model assuming the local thermodynamic equilibrium (LTE), in this non-CE model, the magneto-hydro-dynamics (MHD) method was coupled with the reaction kinetics to obtain the time-dependent species compositions and properties. The current calculation took into account five species in hot gas and 22 chemical reactions in total. The time-dependent species compositions of hot N2 were derived from the mass conservation equation for each species, considering the effect of the convection, diffusion and the chemical reaction. The influence of the non-CE compositions on the arc decaying behavior was realized by updating the thermodynamic and transport properties at each iterative step. The results indicate that the non-CE model can result in the departure of the arc decaying behavior from the LTE model, because it alters the time evolution of the species composition and consequently changes the thermodynamic and transport properties. At the edge of the arc, the time evolutions of the species are dominant by both the diffusion and the chemical reactions while at the center of the arc they are mainly influenced by the chemical reactions. Generally, the non-CE effect can lead to the delay of all the particles’ variations, particularly the electron decay, so that the arc interruption performance will be reduced compared with that in the LTE model.

  4. Spousal recovery support, recovery experiences, and life satisfaction crossover among dual-earner couples.

    Science.gov (United States)

    Park, YoungAh; Fritz, Charlotte

    2015-03-01

    Research has indicated the importance of recovery from work stress for employee well-being and work engagement. However, very little is known about the specific factors that may support or hinder recovery in the context of dual-earner couples. This study proposes spousal recovery support as a potential resource that dual-earner couples can draw on to enhance their recovery experiences and well-being. It was hypothesized that spousal recovery support would be related to the recipient spouse's life satisfaction via his or her own recovery experiences (i.e., psychological detachment, relaxation, and mastery experiences). The study further investigated the crossover of life satisfaction between working spouses as a potential outcome of recovery processes. Data from 318 full-time employed married couples in South Korea were analyzed using structural equation modeling. Results showed that spousal recovery support was positively related to all 3 recovery experiences of the recipient spouse. Moreover, this recovery support was related to the recipient spouse's life satisfaction via relaxation and mastery experiences. Unexpectedly, psychological detachment was negatively related to life satisfaction, possibly indicating a suppression effect. Life satisfaction crossed over between working spouses. No gender differences were found in the hypothesized paths. Based on these findings, theoretical and practical implications are discussed, and future research directions are presented.

  5. "Sizing Up" Codependency Recovery.

    Science.gov (United States)

    Messner, Beth A.

    1996-01-01

    Analyzes codependency related, self-help literature with a dramatistic lens to explore M. Beattie's bibliotherapeutic portrayal of codependency and codependency recovery. Depicts Beattie's "stylistic medicine" for codependency recovery as a three-step, rebirth experience: (1) recognize the codependent pollution within; (2) engage in…

  6. "Sizing Up" Codependency Recovery.

    Science.gov (United States)

    Messner, Beth A.

    1996-01-01

    Analyzes codependency related, self-help literature with a dramatistic lens to explore M. Beattie's bibliotherapeutic portrayal of codependency and codependency recovery. Depicts Beattie's "stylistic medicine" for codependency recovery as a three-step, rebirth experience: (1) recognize the codependent pollution within; (2) engage in…

  7. Using a full annual cycle model to evaluate long-term population viability of the conservation-reliant Kirtland's warbler after successful recovery

    Science.gov (United States)

    Brown, Donald J.; Ribic, Christine; Donner, Deahn M.; Nelson, Mark D.; Bocetti, Carol I.; Deloria-Sheffield, Christie M.

    2017-01-01

    Long-term management planning for conservation-reliant migratory songbirds is particularly challenging because habitat quality in different stages and geographic locations of the annual cycle can have direct and carry-over effects that influence the population dynamics. The Neotropical migratory songbird Kirtland's warbler Setophaga kirtlandii (Baird 1852) is listed as endangered under the U.S. Endangered Species Act and Near Threatened under the IUCN Red List. This conservation-reliant species is being considered for U.S. federal delisting because the species has surpassed the designated 1000 breeding pairs recovery threshold since 2001.To help inform the delisting decision and long-term management efforts, we developed a population simulation model for the Kirtland's warbler that incorporated both breeding and wintering grounds habitat dynamics, and projected population viability based on current environmental conditions and potential future management scenarios. Future management scenarios included the continuation of current management conditions, reduced productivity and carrying capacity due to the changes in habitat suitability from the creation of experimental jack pine Pinus banksiana (Lamb.) plantations, and reduced productivity from alteration of the brown-headed cowbird Molothrus ater (Boddaert 1783) removal programme.Linking wintering grounds precipitation to productivity improved the accuracy of the model for replicating past observed population dynamics. Our future simulations indicate that the Kirtland's warbler population is stable under two potential future management scenarios: (i) continuation of current management practices and (ii) spatially restricting cowbird removal to the core breeding area, assuming that cowbirds reduce productivity in the remaining patches by ≤41%. The additional future management scenarios we assessed resulted in population declines.Synthesis and applications. Our study indicates that the Kirtland's warbler population

  8. Reproducing the observed energy-dependent structure of Earth's electron radiation belts during storm recovery with an event-specific diffusion model

    Science.gov (United States)

    Ripoll, J.-F.; Reeves, G. D.; Cunningham, G. S.; Loridan, V.; Denton, M.; Santolík, O.; Kurth, W. S.; Kletzing, C. A.; Turner, D. L.; Henderson, M. G.; Ukhorskiy, A. Y.

    2016-06-01

    We present dynamic simulations of energy-dependent losses in the radiation belt "slot region" and the formation of the two-belt structure for the quiet days after the 1 March storm. The simulations combine radial diffusion with a realistic scattering model, based data-driven spatially and temporally resolved whistler-mode hiss wave observations from the Van Allen Probes satellites. The simulations reproduce Van Allen Probes observations for all energies and L shells (2-6) including (a) the strong energy dependence to the radiation belt dynamics (b) an energy-dependent outer boundary to the inner zone that extends to higher L shells at lower energies and (c) an "S-shaped" energy-dependent inner boundary to the outer zone that results from the competition between diffusive radial transport and losses. We find that the characteristic energy-dependent structure of the radiation belts and slot region is dynamic and can be formed gradually in ~15 days, although the "S shape" can also be reproduced by assuming equilibrium conditions. The highest-energy electrons (E > 300 keV) of the inner region of the outer belt (L ~ 4-5) also constantly decay, demonstrating that hiss wave scattering affects the outer belt during times of extended plasmasphere. Through these simulations, we explain the full structure in energy and L shell of the belts and the slot formation by hiss scattering during storm recovery. We show the power and complexity of looking dynamically at the effects over all energies and L shells and the need for using data-driven and event-specific conditions.

  9. Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.

    Science.gov (United States)

    Gonzalez, Rodolfo; Garitaonandia, Ibon; Poustovoitov, Maxim; Abramihina, Tatiana; McEntire, Caleb; Culp, Ben; Attwood, Jordan; Noskov, Alexander; Christiansen-Weber, Trudy; Khater, Marwa; Mora-Castilla, Sergio; To, Cuong; Crain, Andrew; Sherman, Glenn; Semechkin, Andrey; Laurent, Louise C; Elsworth, John D; Sladek, John; Snyder, Evan Y; Redmond, D Eugene; Kern, Russell A

    2016-11-01

    Cell therapy has attracted considerable interest as a promising therapeutic alternative for patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural tissue can achieve considerable biochemical and clinical improvements in PD. However, the source of fetal tissue grafts is limited and ethically controversial. Human parthenogenetic stem cells offer a good alternative because they are derived from unfertilized oocytes without destroying potentially viable human embryos and can be used to generate an unlimited supply of neural cells for transplantation. We have previously reported that human parthenogenetic stem cell-derived neural stem cells (hpNSCs) successfully engraft, survive long term, and increase brain dopamine (DA) levels in rodent and nonhuman primate models of PD. Here we report the results of a 12-month transplantation study of hpNSCs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned African green monkeys with moderate to severe clinical parkinsonian symptoms. The hpNSCs manufactured under current good manufacturing practice (cGMP) conditions were injected bilaterally into the striatum and substantia nigra of immunosuppressed monkeys. Transplantation of hpNSCs was safe and well tolerated by the animals with no dyskinesia, tumors, ectopic tissue formation, or other test article-related serious adverse events. We observed that hpNSCs promoted behavioral recovery; increased striatal DA concentration, fiber innervation, and number of dopaminergic neurons; and induced the expression of genes and pathways downregulated in PD compared to vehicle control animals. These results provide further evidence for the clinical translation of hpNSCs and support the approval of the world's first pluripotent stem cell-based phase I/IIa study for the treatment of PD (Clinical Trial Identifier NCT02452723).

  10. Recovery Amid Pro-Anorexia: Analysis of Recovery in Social Media

    Science.gov (United States)

    Chancellor, Stevie; Mitra, Tanushree; De Choudhury, Munmun

    2017-01-01

    Online communities can promote illness recovery and improve well-being in the cases of many kinds of illnesses. However, for challenging mental health condition like anorexia, social media harbor both recovery communities as well as those that encourage dangerous behaviors. The effectiveness of such platforms in promoting recovery despite housing both communities is underexplored. Our work begins to fill this gap by developing a statistical framework using survival analysis and situating our results within the cognitive behavioral theory of anorexia. This model identifies content and participation measures that predict the likelihood of recovery. From our dataset of over 68M posts and 10K users that self-identify with anorexia, we find that recovery on Tumblr is protracted - only half of the population is estimated to exhibit signs of recovery after four years. We discuss the effectiveness of social media in improving well-being around anorexia, a unique health challenge, and emergent questions from this line of work. PMID:28840201

  11. Sesame oil improves functional recovery by attenuating nerve oxidative stress in a mouse model of acute peripheral nerve injury: role of Nrf-2.

    Science.gov (United States)

    Hsu, Che-Chia; Huang, Hui-Cheng; Wu, Po-Ting; Tai, Ta-Wei; Jou, I-Ming

    2016-12-01

    Peripheral nervous injury (PNI) is a common form of trauma in modern society, especially in sport players. Despite the advance of therapy for PNI, the recovery of function can never reach the preinjury level after treatments. Recently, inhibiting neural oxidative stress shows a beneficial effect in improving functional recovery after PNI. In addition, sesame oil has been reported to possess the excellent antioxidative properties. However, whether sesame oil can improve the functional recovery after PNI by its antioxidative effect has never been investigated. Thirty mice were randomly divided into five groups of six: group I mice received sham operation; group II mice received sciatic nerve crush; and groups III-V mice daily ingested 0.5, 1 and 2 ml/kg of sesame oil for 6 days, respectively, after sciatic nerve crush. Oxidative stress, GAP43 and nuclear Nrf2 levels as well as spinal somatosensory evoked potentials were assessed on day 6, while paw withdrawal latency and sciatic function index were assessed on days 0, 3, and 6. Sesame oil significantly decreased lipid peroxidation and increased nuclear factor erythroid 2-related factor 2 and GAP43 expression in sciatic nerve. Furthermore, sesame oil improved electrophysiological and functional assessments in mice with sciatic nerve crush. In conclusion, sesame oil may improve nerve functional recovery by attenuating nerve oxidative stress in mouse acute peripheral nerve injury. Further, application of natural product sesame oil may be an alternative approach for improving nerve functional recovery in the clinical setting. Copyright © 2016. Published by Elsevier Inc.

  12. The work of recovery on two assertive community treatment teams.

    Science.gov (United States)

    Salyers, Michelle P; Stull, Laura G; Rollins, Angela L; Hopper, Kim

    2011-05-01

    The compatibility of recovery work with the Assertive Community Treatment (ACT) model has been debated; and little is known about how to best measure the work of recovery. Two ACT teams with high and low recovery orientation were identified by expert consensus and compared on a number of dimensions. Using an interpretive, qualitative approach to analyze interview and observation data, teams differed in the extent to which the environment, team structure, staff attitudes, and processes of working with consumers supported principles of recovery orientation. We present a model of recovery work and discuss implications for research and practice.

  13. 工程车辆联合制动与能量回收的建模与仿真%Modeling and Simulation of Combined Braking and Energy Recovery for Construction Vehicle

    Institute of Scientific and Technical Information of China (English)

    李竹芳; 李鹏; 蔡普; 王大江; 杨龙

    2015-01-01

    This paper describes the mechanism of energy recovery and combined braking system, and establishes its mathematical model. Matlab/Simulink simulation software is use to analyze and calculate the braking efficiency and energy recovery conditions during braking. The results show that energy recovery can improve braking efficiency and saving energy. The energy recovery and dynamic braking test is carried out on comprehensive test bench, the results verifies the correctness and reliability of simulation results.%阐述了联合制动与能量回收机理。建立了能量回收与联合制动的数学模型,利用Matlab/Simulink仿真软件分析和计算了一次制动过程中制动效率和能量回收的情况。结果表明,制动过程中进行能量回收可以很好地提高制动效率且节约能源。利用综合试验台进行了能量回收与动力制动试验,试验结果很好地验证了仿真结果的正确性和可靠性。

  14. Domestic wastewater heat recovery

    OpenAIRE

    Veijola, T.

    2017-01-01

    The aim of this thesis is to study and explain the purpose and the function of drain water heat exchangers. The thesis goes over theory behind heat transfer and heat exchangers and presents the general solutions of domestic drain water heat recovery systems. Systems gone over in detail are the different general shower drain water heat recovery systems. Another part of the thesis is a case study of an actual shower drain water heat recovery system of a Finnish household. The purpose of th...

  15. Structure-independent disaster recovery: Concept, architecture and implementations

    Institute of Scientific and Technical Information of China (English)

    ZHENG WeiMin; FANG BinXing

    2009-01-01

    Disaster recovery (DR) techniques ensure the data safety and service continuity under different nat-ural and human-made disasters by constructing a high reliable storage system. Traditional disaster recovery methods are structure-dependent. It is hard to share the DR resources between different DR systems, which made it expensive. We present a structure-independent disaster recovery theory and its implementation methods in this paper. By backup the whole system but not just the data, the goal of device and application-independent disaster recovery has been achieved. We further present a parallel recovery model and an on demand data retrieval method based on the theory. Some implementation details of prototype recovery system are also discussed. With the methods independent from specific devices or applications, the cost of disaster recovery infrastructure can be essentially reduced by re-source sharing. Experiments show that the recovery time has also been greatly shortened with little service degradation.

  16. Unequal Recovery? Federal Resource Distribution after a Midwest Flood Disaster.

    Science.gov (United States)

    Muñoz, Cristina E; Tate, Eric

    2016-05-17

    Following severe flooding in 2008, three Iowa communities acquired over 1000 damaged properties to support disaster recovery and mitigation. This research applies a distributive justice framework to analyze the distribution of disaster recovery funds for property acquisition. Two research questions drive the analysis: (1) how does recovery vary by acquisition funding source; and (2) what is the relationship between recovery and vulnerable populations? Through spatial econometric modeling, relative recovery is compared between two federal programs that funded the acquisitions, and across socially vulnerable populations. The results indicate both distributive and temporal inequalities in the allocation of federal recovery funds. In particular, Latino and elderly populations were associated with lower recovery rates. Recommendations for future research in flood recovery and acquisitions are provided.

  17. Alcoholics anonymous and twelve steps%AA与戒酒的十二个步骤--访美国嗜酒者互诫协会札记

    Institute of Scientific and Technical Information of China (English)

    郭崧; 李冰

    2003-01-01

    @@ AA(Alcoholics Anonymous)的戒酒方案见诸于几乎所有有关药物依赖的教科书.在世界范围内,采纳AA十二个步骤的治疗原则来实现戒除成瘾性障碍的组织(如NA:Narcotics Anonymous,CA:CocaineAnonymous等)已超过250个.

  18. Metal recovery from high-grade WEEE

    DEFF Research Database (Denmark)

    Bigum, Marianne; Brogaard, Line Kai-Sørensen; Christensen, Thomas Højlund

    2012-01-01

    and refining of ore. The resource recovery per tonne of high-grade WEEE ranged from 2 g of palladium to 386 kg of iron. Quantified in terms of person-equivalents the recovery of palladium, gold, silver, nickel and copper constituted the major environmental benefit of the recovery of metals from WEEE......Based on available data in the literature the recovery of aluminium, copper, gold, iron, nickel, palladium and silver from high-grade WEEE was modeled by LCA. The pre-treatment of WEEE included manual sorting, shredding, magnetic sorting, Eddy-current sorting, air classification and optical sorting....... These benefits are most likely underestimated in the model, since we did not find adequate data to include all the burdens from mining and refining of ore; burdens that are avoided when metals are recovered from WEEE. The processes connected to the pre-treatment of WEEE were found to have little environmental...

  19. Model-based assessment of the potential of seasonal aquifer thermal energy storage and recovery as a groundwater ecosystem service for the Brussels-Capital Region

    Science.gov (United States)

    Anibas, Christian; Huysmans, Marijke

    2015-04-01

    Urban areas are characterized by their concentrated demand of energy, applying a high pressure on urban ecosystems including atmosphere, soils and groundwater. In the light of global warming, urbanization and an evolving energy system, it is important to know how urbanized areas can contribute to their own energy demands. One option is to use the possibilities aquifers offer as an ecosystem service (BONTE et al., 2011). If used effectively an improvement in air and groundwater quality is achieved. Additionally, the more efficient distribution of the used energy may also lead to a decrease in primary energy consumption (ZUURBIER, 2013). Therefore, investigations of the potential of seasonal aquifer thermal energy storage and recovery (ATES) for the Brussels-Capital Region, Belgium is being conducted. The potential of ATES systems are of special interest for energy demands in high density urban areas because of such infrastructure as office buildings, schools, hospitals and shopping malls. In an open water circuit ATES systems consist of two or more groundwater wells, where in seasonal cycles one subtracts and the other recharges water to the aquifer. Heat pumps use the heat capacity of water for heating or cooling a building. An important limitation of the methodology is the quality of the groundwater used (i.e. precipitation of Fe- or Mn-oxides can decrease the yield). However, ATES systems on the other hand can also improve groundwater quality and groundwater ecosystems. The current knowledge of the potential for ATES systems in the Brussels-Capital Region is based on geological assessments from VITO (2007). The Brussels-Capital Region is divided into a western and eastern section with respect to geology. While the western part has less favorable conditions for ATES, the eastern is composed of the Brussels Sand formation, which is a 20-40 m thick aquifer layer that has the highest potential for ATES systems in the region. By applying groundwater flow and heat

  20. Recovery of immune competence following sublethal X irradiation of young and old mice: a model for studying age-related loss of immunologic homeostasis

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, W.J. (VA Wadsworth Medical Center, Los Angeles, CA); Perkins, E.H.; Makinodan, T.

    1982-01-01

    Age-related alteration in lymphohematopoietic homeostasis was assessed kinetically by determining immunologic and stem-cell regenerating capacities of young (5-7 months), middle-aged (13 months), and old (23-24 months) C3H and C57BL/6 mice following their exposure to 500 R. Immunologic activities were based on the ability of spleen cells to respond to sheep erythrocytes, phytohemagglutinin, and bacterial lipopolysaccharide. Stem-cell activity was based on the ability of splenic and bone marrow cells to form colonies in vivo. Reflective of age-related homeostatic imbalance was alteration in the (a) time of recovery, (b) rate of regeneration, and (c) capacity of the regenerating system to overshoot the preirradition steady-state level. Most of the immunologic parameters showed a delay in the time of recovery in old mice. In contrast, the time of recovery of stem cells in old mice was equal to or faster than that in young mice. Furthermore, the magnitude of regeneration of stem cells was greater in old than young mice. These results suggest that recovery of immunologic activities in old mice is delayed partly because of the inability of their stem cells to rapidly generate immunocompetent progenies.

  1. Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model.

    Science.gov (United States)

    Hirata, Kenji; Kuge, Yuji; Yokota, Chiaki; Harada, Akina; Kokame, Koichi; Inoue, Hiroyasu; Kawashima, Hidekazu; Hanzawa, Hiroko; Shono, Yuji; Saji, Hideo; Minematsu, Kazuo; Tamaki, Nagara

    2011-05-20

    Although an enriched environment enhances functional recovery after ischemic stroke, the mechanism underlying this effect remains unclear. We previously reported that brain derived neurotrophic factor (BDNF) gene expression decreased in rats housed in an enriched environment for 4 weeks compared to those housed in a standard cage for the same period. To further clarify the relationship between the decrease in BDNF and functional recovery, we investigated the effects of differential 2-week housing conditions on the mRNA of BDNF and protein levels of proBDNF and mature BDNF (matBDNF). After transient occlusion of the right middle cerebral artery of male Sprague-Dawley rats, we divided the rats into two groups: (1) an enriched group housed multiply in large cages equipped with toys, and (2) a standard group housed alone in small cages without toys. Behavioral tests before and after 2-week differential housing showed better neurological recovery in the enriched group than in the standard group. Synaptophysin immunostaining demonstrated that the density of synapses in the peri-infarct area was increased in the enriched group compared to the standard group, while infarct volumes were not significantly different. Real-time reverse transcription polymerase chain reaction, Western blotting and immunostaining all revealed no significant difference between the groups. The present results suggest that functional recovery cannot be ascribed to an increase in matBDNF or a decrease in proBDNF but rather to other underlying mechanisms.

  2. Spatially Dispersed Employee Recovery

    DEFF Research Database (Denmark)

    Hvass, Kristian Anders; Torfadóttir, Embla

    2014-01-01

    Employee recovery addresses either employee well-being or management's practices in aiding employees in recovering themselves following a service failure. This paper surveys the cabin crew at a small, European, low-cost carrier and investigates employees' perceptions of management practices to aid...... personnel achieve service recovery. Employee recovery within service research often focuses on front-line employees that work in a fixed location, however a contribution to the field is made by investigating the recovery of spatially dispersed personnel, such as operational personnel in the transport sector......, who have a work place away from a fixed or central location and have minimal management contact. Results suggest that the support employees receive from management, such as recognition, information sharing, training, and strategic awareness are all important for spatially dispersed front...

  3. Recovery Action Mapping Tool

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Recovery Action Mapping Tool is a web map that allows users to visually interact with and query actions that were developed to recover species listed under the...

  4. Enhanced oil recovery

    Energy Technology Data Exchange (ETDEWEB)

    Chakma, A.; Rafiq Islam, M.; Berruti, F.

    1991-01-01

    Some forty to sixty percent of the original oil in place typically remains trapped in the reservoir after primary and secondary recoveries. Enhanced oil recovery refers to the recovery of the residual oil by different techniques. Many of the existing and proposed enhanced oil recovery techniques require sound understanding of basic chemical engineering principles such as fluid flow, heat and mass transfer, interfacial phenomena etc. Chemical EOR techniques require a good understanding of interfacial phenomena, chemical reaction, multicomponent absorption. Understanding of the fundamentals of the various EOR processes is not adequate. EOR is increasingly attracting a growing number of chemical engineers and, as a result, some of the fundamental aspect of EOR are now being investigated. However, much more remains to be done and chemical engineers can play an important role in providing a better understanding of EOR fundamentals. This volume presents selected papers on EOR presented at AICHE meetings.

  5. A Bumpy Recovery

    Institute of Scientific and Technical Information of China (English)

    CHEN FENGYING

    2010-01-01

    @@ The world economic situation has been extremely complicated in 2010. This year saw fluctuating market confidence,changing commodity prices, imbalanced economic recovery, diverse economic policies, lingering trade protectionism, and fierce currency battles.

  6. Recovery Audit Program

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Recovery Audit Programs mission is to identify and correct Medicare improper payments through the efficient detection and collection of overpayments made on...

  7. Disaster Debris Recovery Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — The US EPA Region 5 Disaster Debris Recovery Database includes public datasets of over 3,500 composting facilities, demolition contractors, haulers, transfer...

  8. Silver recovery system data

    Energy Technology Data Exchange (ETDEWEB)

    Boulineau, B.

    1991-08-26

    In August of 1990 the Savannah River Site Photography Group began testing on a different type of silver recovery system. This paper describes the baseline study and the different phases of installation and testing of the system.

  9. FEMA Disaster Recovery Centers

    Data.gov (United States)

    Department of Homeland Security — This is a search site for FEMA's Disaster Recovery Centers (DRC). A DRC is a readily accessible facility or mobile office set up by FEMA where applicants may go for...

  10. Localized recovery of complex networks against failure

    Science.gov (United States)

    Shang, Yilun

    2016-07-01

    Resilience of complex networks to failure has been an important issue in network research for decades, and recent studies have begun to focus on the inverse recovery of network functionality through strategically healing missing nodes or edges. However, the effect of network recovery is far from fully understood, and a general theory is still missing. Here we propose and study a general model of localized recovery, where a group of neighboring nodes are restored in an invasive way from a seed node. We develop a theoretical framework to compare the effect of random recovery (RR) and localized recovery (LR) in complex networks including Erdős-Rényi networks, random regular networks, and scale-free networks. We find detailed phase diagrams for the subnetwork of occupied nodes and the “complement network” of failed nodes under RR and LR. By identifying the two competitive forces behind LR, we present an analytical and numerical approach to guide us in choosing the appropriate recovery strategy and provide estimation on its effect by using the degree distribution of the original network as the only input. Our work therefore provides insight for quantitatively understanding recovery process and its implications in infrastructure protection in various complex systems.

  11. New Results in Discrete-Time Loop Transfer Recovery

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Søgaard-Andersen, Per

    1988-01-01

    in terms of the system zeros and the corresponding zero-directions. Full-order as well as minimal-order observers are treated. Further it is shown how exact recovery is also applicable to non-minimum phase plants. In this case the achievable performance is parameterized explicitly.......For discrete-time compensators incorporating prediction observers asymptotic loop transfer recovery is not feasible. Instead loop transfer recovery objectives must be satisfied via exact recovery techniques. In this note the model-based compensators which achieves exact recovery are parametrized...

  12. Rational use of energy via heat recovery

    Energy Technology Data Exchange (ETDEWEB)

    Groscurth, H.M. (Inst. fuer Energiewirtschaft und Rationelle Energieanwendung (IER), Stuttgart Univ. (Germany))

    1992-01-01

    The linear, stochastic optimization model ECCO has been developed as a computerized planning tool for case studies on integrated energy management involving heat recovery by heat exchanger networks, heat pumps and cogeneration. The procedure of stochastic optimization is described in detail. For a model city, which consists of three districts with together nearly 20,000 inhabitants and 4 industrial companies, we obtain the following results: Via heat recovery and cogeneration, the primary energy input into the energy system of the model city may be reduced by 25% compared to a status quo scenario. At the same time, the CO[sub 2]-emissions are reduced by 31% with some fuel switching from coal to natural gas being involved. Introducing waste heat recovery and cogeneration into the model city at the current low energy price level would increase the cost of the energy system by at least 41% with respect to the status quo. (orig./BWI)

  13. Prognostic value of late heart rate recovery after treadmill exercise.

    Science.gov (United States)

    Johnson, Nils P; Goldberger, Jeffrey J

    2012-07-01

    Recovery from exercise can be divided into an early, rapid period and a late, slower period. Although early heart rate (HR) recovery 1 minute after treadmill exercise independently predicts survival, the prognostic value of late HR recovery has not been well studied. The aim of this study was to evaluate the independent prognostic value of late HR recovery for all-cause mortality. A total of 2,082 patients referred to the nuclear cardiology laboratory of an urban academic medical center for treadmill exercise with imaging from August 1998 to December 2003 were followed for all-cause mortality. During 9.9 ± 1.5 years of follow-up, 196 deaths (9%) occurred. To avoid overlap with early HR recovery or the baseline HR, late HR recovery was defined as the percentage of the cycle length change between rest and peak exercise that had been recovered after 5 minutes. Lower values represent impaired recovery, by analogy with 1-minute HR recovery. Impaired late HR recovery was a significant univariate predictor of all-cause mortality (hazard ratio 0.28 per percentage, 95% confidence interval 0.17 to 0.46, p recovery, with independent prognostic value (adjusted hazard ratio 0.58, 95% confidence interval 0.41 to 0.84, p = 0.004). In conclusion, late HR recovery after treadmill exercise stress adds prognostic value for all-cause mortality to a multivariate model including early, 1-minute HR recovery.

  14. Electrospun Nanofibers Loaded with Quercetin Promote the Recovery of Focal Entrapment Neuropathy in a Rat Model of Streptozotocin-Induced Diabetes

    Science.gov (United States)

    Thipkaew, Chonlathip

    2017-01-01

    In this study, quercetin-loaded zein-based nanofibers were developed using electrospinning technique. The therapeutic effect of these quercetin-loaded nanofibers on neuropathy in streptozotocin- (STZ-) induced diabetes in rats was assessed. Diabetic condition was induced in male Wistar rats by STZ, after which a crush injury of the right sciatic nerve was performed to induce mononeuropathy. Functional recovery was assessed using walking track analysis, measurements of foot withdrawal reflex, nerve conduction velocity, and morphological analysis. The oxidative stress status and the ratio of phosphorylated extracellular recognition kinase (pERK)/extracellular recognition kinase (ERK) expression in the nerve lesion were also assessed in order to elucidate the potential mechanisms involved. Results showed that quercetin-loaded zein-based nanofibers slightly enhanced functional recovery from neuropathy in STZ-diabetic rats. The potential mechanism might partially involve improvements in oxidative stress status and the ratio of pERK/ERK expression in the nerve lesion. PMID:28251151

  15. 液压蓄能器制动能量回收系统建模与仿真%Hydraulic Accumulator Brake Energy Recovery System Modeling and Simulation

    Institute of Scientific and Technical Information of China (English)

    殷允朝

    2016-01-01

    本文分析了液压蓄能器混合动力制动回收系统基本组成和工作原理并建立力学模型,重点研究了基于Matlab/simulink仿真和传动比的匹配。结果表明:在最高转速变化允许范围内合理选择传动比的参数匹配,能缩短制动时间和获取较高的制动回收率。%Hydraulic accumulator hybrid brake recovery system basic composition and working principle are analyzed,Based on Matlab/simulink and the ratio of matching is key research, The results show that:In the range of allowable maximum speed change the rational selection of parameters matching ratio, Braking time is shortened and Brake recovery rate was improved.

  16. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model.

    Directory of Open Access Journals (Sweden)

    Desirée L Salazar

    Full Text Available BACKGROUND: Traumatic spinal cord injury (SCI results in partial or complete paralysis and is characterized by a loss of neurons and oligodendrocytes, axonal injury, and demyelination/dysmyelination of spared axons. Approximately 1,250,000 individuals have chronic SCI in the U.S.; therefore treatment in the chronic stages is highly clinically relevant. Human neural stem cells (hCNS-SCns were prospectively isolated based on fluorescence-activated cell sorting for a CD133(+ and CD24(-/lo population from fetal brain, grown as neurospheres, and lineage restricted to generate neurons, oligodendrocytes and astrocytes. hCNS-SCns have recently been transplanted sub-acutely following spinal cord injury and found to promote improved locomotor recovery. We tested the ability of hCNS-SCns transplanted 30 days post SCI to survive, differentiate, migrate, and promote improved locomotor recovery. METHODS AND FINDINGS: hCNS-SCns were transplanted into immunodeficient NOD-scid mice 30 days post spinal cord contusion injury. hCNS-SCns transplanted mice demonstrated significantly improved locomotor recovery compared to vehicle controls using open field locomotor testing and CatWalk gait analysis. Transplanted hCNS-SCns exhibited long-term engraftment, migration, limited proliferation, and differentiation predominantly to oligodendrocytes and neurons. Astrocytic differentiation was rare and mice did not exhibit mechanical allodynia. Furthermore, differentiated hCNS-SCns integrated with the host as demonstrated by co-localization of human cytoplasm with discrete staining for the paranodal marker contactin-associated protein. CONCLUSIONS: The results suggest that hCNS-SCns are capable of surviving, differentiating, and promoting improved locomotor recovery when transplanted into an early chronic injury microenvironment. These data suggest that hCNS-SCns transplantation has efficacy in an early chronic SCI setting and thus expands the "window of opportunity" for

  17. Automated cold temperature cycling improves in vitro platelet properties and in vivo recovery in a mouse model compared to continuous cold storage.

    Science.gov (United States)

    Skripchenko, Andrey; Gelderman, Monique P; Awatefe, Helen; Turgeon, Annette; Thompson-Montgomery, Dedeene; Cheng, Chunrong; Vostal, Jaroslav G; Wagner, Stephen J

    2016-01-01

    Platelets (PLTs) stored at cold temperatures (CTs) for prolonged time have dramatically reduced bacterial growth but poor survival when infused. A previous study demonstrated that human PLTs stored with manual cycling between 4 °C (12 hr) and 37 °C (30 min) and infused into severe combined immunodeficient (SCID) mice had survivals similar to or greater than those stored at room temperature (RT). In this study, the in vitro and in vivo properties of PLTs stored in an automated incubator programmed to cycle between 5 °C (11 hr) and 37 °C (1 hr) were evaluated. A Trima apheresis unit (n = 12) was aliquoted (60 mL) in CLX bags. One sample was stored with continuous agitation (RT), a second sample was stored at 4-6 °C without agitation (CT), and a third sample was placed in an automated temperature cycler with 5 minutes of agitation during the warm-up period (thermocycling [TC]). PLTs were assayed for several relevant quality variables. On Day 7, PLTs were infused into SCID mice and in vivo recovery was assessed at predetermined time points after transfusion. The glucose consumption rate, morphology score, hypotonic shock recovery level, and aggregation levels were increased and mitochondrial reactive oxygen species accumulations were decreased in TC-PLTs compared to those of CT-PLTs. The pH and Annexin V binding were comparable to those of RT-PLTs. All TC-PLTs had greater recovery than CT-PLTs and were comparable to RT-PLTs. PLTs stored under automated TC conditions have improved in vivo recovery and improved results for a number of in vitro measures compared to CT-PLTs. © 2015 AABB.

  18. A novel energy recovery system for parallel hybrid hydraulic excavator.

    Science.gov (United States)

    Li, Wei; Cao, Baoyu; Zhu, Zhencai; Chen, Guoan

    2014-01-01

    Hydraulic excavator energy saving is important to relieve source shortage and protect environment. This paper mainly discusses the energy saving for the hybrid hydraulic excavator. By analyzing the excess energy of three hydraulic cylinders in the conventional hydraulic excavator, a new boom potential energy recovery system is proposed. The mathematical models of the main components including boom cylinder, hydraulic motor, and hydraulic accumulator are built. The natural frequency of the proposed energy recovery system is calculated based on the mathematical models. Meanwhile, the simulation models of the proposed system and a conventional energy recovery system are built by AMESim software. The results show that the proposed system is more effective than the conventional energy saving system. At last, the main components of the proposed energy recovery system including accumulator and hydraulic motor are analyzed for improving the energy recovery efficiency. The measures to improve the energy recovery efficiency of the proposed system are presented.

  19. Recovery from vestibular ototoxicity

    Science.gov (United States)

    Black, F. O.; Gianna-Poulin, C.; Pesznecker, S. C.

    2001-01-01

    OBJECTIVE: Determine whether subjects with documented vestibular ototoxicity recover vestibular function and, if so, investigate the recovery dynamics. STUDY DESIGN: Prospective and retrospective reviews and repeated measures. SETTING: Clinical research and technology center. SUBJECTS: Twenty-eight subjects who received vestibulotoxic medications were followed for at least 12 months after initial treatment. CONTROLS: Our subject sample was compared with a published database of normal individuals. INTERVENTIONS: All 28 subjects received systemically administered medications known to be ototoxic. The subjects' treating physicians controlled medication, dosage, and administration schedules. MAIN OUTCOME MEASURES: Tests of horizontal canal vestibulo-ocular function were performed. Subjects' auditory and vestibular symptoms were recorded. RESULTS: Eleven subjects (39%) showed changes in horizontal canal vestibulo-ocular gain constant (GC) and/or time constant (TC) consistent with vestibular ototoxicity. When tested 1 year after ototoxic drug administration, eight of the nine subjects who experienced