WorldWideScience

Sample records for twelve male infantry

  1. On Light Infantry.

    Science.gov (United States)

    1987-05-01

    the Israeli’s use during ,J their Armor Corps rite of passage at Masada or the five day Ranger Indoctrination Program of the Ranger Regiment or even... rite of passage by creating a five day program for all soldiers. It emphasizes esprit and fundamental field craft of an infantry soldier The division

  2. Brain Volume Reductions within Multiple Cognitive Systems in Male Preterm Children at Age Twelve

    Science.gov (United States)

    Kesler, Shelli R.; Reiss, Allan L.; Vohr, Betty; Watson, Christa; Schneider, Karen C.; Katz, Karol H.; Maller-Kesselman, Jill; Silbereis, John; Constable, R. Todd; Makuch, Robert W.; Ment, Laura R.

    2012-01-01

    Objectives To more precisely examine regional and subregional microstructural brain changes associated with preterm birth. Study design We obtained brain volumes from 29 preterm children, age 12 years, with no ultrasound scanning evidence of intraventricular hemorrhage or cystic periventricular leukomalacia in the newborn period, and 22 age- and sex-matched term control subjects. Results Preterm male subjects demonstrated significantly lower white matter volumes in bilateral cingulum, corpus callosum, corticospinal tract, prefrontal cortex, superior and inferior longitudinal fasciculi compared with term male subjects. Gray matter volumes in prefrontal cortex, basal ganglia, and temporal lobe also were significantly reduced in preterm male subjects. Brain volumes of preterm female subjects were not significantly different from those of term female control subjects. Voxel-based morphometry results were not correlated with perinatal variables or cognitive outcome. Higher maternal education was associated with higher cognitive performance in preterm male subjects. Conclusions Preterm male children continue to demonstrate abnormal neurodevelopment at 12 years of age. However, brain morphology in preterm female children may no longer differ from that of term female children. The neurodevelopmental abnormalities we detected in preterm male subjects appear to be relatively diffuse, involving multiple neural systems. The relationship between aberrant neurodevelopment and perinatal variables may be mediated by genetic factors, environmental factors, or both reflected in maternal education level. PMID:18346506

  3. Validation of ASVAB against Infantry Job Performance

    Science.gov (United States)

    1990-12-01

    Job Performance Measurement (JPM) project. ASVAB was highly related to hands-on performance of critical infantry tasks, written infantry job knowledge tests, and grades in initial infantry training courses. The validity of ASVAB was also found to extend into the second term of service by being able to predict the performance of infantry unit leaders. Experience in the Marine Corps, as measured by time in service, rank, and recency of task performance, had a

  4. Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling.

    Science.gov (United States)

    Gaddini, Gino W; Grant, Kathleen A; Woodall, Andrew; Stull, Cara; Maddalozzo, Gianni F; Zhang, Bo; Turner, Russell T; Iwaniec, Urszula T

    2015-02-01

    Chronic heavy alcohol consumption is a risk factor for cortical bone fractures in males. The increase in fracture risk may be due, in part, to reduced bone quality. Intracortical (osteonal) bone remodeling is the principle mechanism for maintaining cortical bone quality. However, it is not clear how alcohol abuse impacts intracortical bone remodeling. This study investigated the effects of long-duration heavy alcohol consumption on intracortical bone remodeling in a non-human primate model. Following a 4-month induction period, male rhesus macaques (Macaca mulatta, n=21) were allowed to voluntarily self-administer water or alcohol (4% ethanol w/v) for 22h/d, 7 d/wk for 12months. Control monkeys (n=13) received water and an isocaloric maltose-dextrin solution. Tetracycline hydrochloride was administered orally 17 and 3days prior to sacrifice for determination of active mineralization sites. Animals in the alcohol group consumed 2.7±0.2g alcohol/kg/d (mean±SE) during the 12months of self-administration, resulting in a mean daily blood alcohol concentration of 77±9mg/dl from samples taken at 7h after the start of a daily session. However, blood alcohol concentration varied widely from day to day, with peak levels exceeding 250mg/dl, modeling a binge-drinking pattern of alcohol consumption. The skeletal response to alcohol was determined by densitometry, microcomputed tomography and histomorphometry. Significant differences in tibial bone mineral content, bone mineral density, and cortical bone architecture (cross-sectional volume, cortical volume, marrow volume, cortical thickness, and polar moment of inertia) in the tibial diaphysis were not detected with treatment. However, cortical porosity was lower (1.8±0.5 % versus 0.6±0.1 %, p=0.021) and labeled osteon density was lower (0.41±0.2/mm(2)versus 0.04±0.01/mm(2), premodeling. In concordance, plasma CTx was lower (2.5±0.3ng/ml versus 1.7±0.1ng/ml, p=0.028) in the alcohol group. These results suggest that

  5. Safety of over twelve hundred infant male circumcisions using the Mogen clamp in Kenya.

    Directory of Open Access Journals (Sweden)

    Marisa R Young

    Full Text Available BACKGROUND: Several sub-Saharan African countries plan to scale-up infant male circumcision (IMC for cost-efficient HIV prevention. Little data exist about the safety of IMC in East and southern Africa. We calculated adverse event (AE rate and risks for AEs associated with introduction of IMC services at five government health facilities in western Kenya. METHODS: AE data were analyzed for IMC procedures performed between September, 2009 and November, 2011. Healthy infants aged ≤ 2 months and weighing ≥ 2.5 kg were eligible for IMC. Following parental consent, trained clinicians provided IMC services free of charge under local anesthesia using the Mogen clamp. Odds ratios and 95% confidence intervals were used to explore AE risk factors. FINDINGS: A total of 1,239 IMC procedures were performed. Median age of infants was 4 days (IQR=1, 16. The overall AE rate among infants reviewed post-operatively was 2.7% (18/678; 95%CI: 1.4, 3.9. There was one severe AE involving excision of a small piece of the lateral aspect of the glans penis. Other AEs were mild or moderate and were treated conservatively. Babies one month of age or older were more likely to have an AE (OR 3.20; 95%CI: 1.23, 8.36. AE rate did not differ by nurse versus clinical officer or number of previous procedures performed. CONCLUSION: IMC services provided in Kenyan Government hospitals in the context of routine IMC programming have AE rates comparable to those in developed countries. The optimal time for IMC is within the first month of life.

  6. Evaluation of the Performance of Females as Light Infantry Soldiers

    Directory of Open Access Journals (Sweden)

    Aharon S. Finestone

    2014-01-01

    Full Text Available A few countries permit women to serve in combat roles, but their long term performance in these positions has not been reported. The incidences of overuse injuries and attrition of 85 male and 235 female recruits in a light infantry brigade was followed in a three-year prospective study. Females were shorter (162 cm, CI 161–163 cm than males (174 cm, CI 173–176, had more body fat (18.9 kg, CI 18.2–19.6 kg than males (12.6 kg, 11.3–13.8 kg, had lower V˙O2max (36.8 mL·min−1·kg−1, CI 35.8–37.78 mL·min−1·kg−1 than males (50.48 mL·min−1·kg−1, CI 48.4 to 52.48 mL·min−1·kg−1, had more stress fractures (21.0%, 95% CI 16.2–26.5% than males (2.3%, CI 0.3–8.2%, and had more anterior knee pain (41.2%, CI 34.9–47.7% than males (24.7%, CI 16.0–35.2%. Three-year attrition was 28% CI 22–34% for females and 37% CI 26–48% for males. The females in this study successfully served as light infantry soldiers. Their lower fitness and high incidence of overuse injuries might impede service as regular infantry soldiers.

  7. fireforce - one man's war in the rhodesian light infantry

    African Journals Online (AJOL)

    The history of the Rhodesian Light Infantry is an illustrious one. The. RLI produced many of the senior brass who led the Rhodesian Army including Gen ... contains three sections of colour photographs, mainly taken from Chris. Cocks' private ...

  8. A Light Infantry Division for Airland Battle-Future

    Science.gov (United States)

    1990-01-29

    infantry with modern high technology . SCHOOL OF ADVANCED MILITARY STUDIES MONOGRAPH APPROVAL Major Mark Van Drie Title of Monograph: A Light Infantry...tre reauirements of the f uturG’ batt lef ield. It conJcludes m -at 7h miisersed, Moble sml unit tactics of lgtifnr i dominate the future batt...tactical success: technical means are simply one factor in the combat power eqation. High technology weapons and equipment provide both advantages and - 7

  9. Integrating Intelligence and Building Teams Within the Infantry Immersion Trainer

    Science.gov (United States)

    2009-09-01

    incorporating intelligence briefs and debriefs with a Squad Planning Operations Center ( SPOC ) supported by suitable technologies improved infantry... SPOC ). The most statistically significant difference between the groups came from the participants’ self-assessment on training confidence and overall...success of training. Members of the experimental group, after utilizing the SPOC for planning, felt more confident in completing their training tasks

  10. Impact of the Phase 2 Infantry Advanced Leader Course (ALC)

    Science.gov (United States)

    2012-07-01

    MTT) version]. Existing course content focuses on Infantry war- fighting skills, combat leadership, and the planning and conducting of squad level...understanding of learning materials (Bransford, Brown, & Cocking , 2000) and subsequent far transfer. Overlearning. As noted by Bransford, Brown, and... Cocking (2000), without an adequate level of initial learning, transfer cannot be expected despite the relevance of the training to the individual

  11. Improving Junior Infantry Officer Leader Development and Performance

    Science.gov (United States)

    2017-06-09

    responsible for the critical role of professionally developing these young officers, and yet the junior officer was not a master of these developmental ...effectively balance his individual development or the long-term needs of the Army, with the immediate needs of their organizations . As a result...positive side, it allows infantry officers to experience more diverse, Army-wide, developmental experiences and assignments. This is good for developing

  12. 77 FR 6865 - Pricing for 2012 Infantry Soldier Silver Dollar and 2012 Star-Spangled Banner Commemorative Coin...

    Science.gov (United States)

    2012-02-09

    ... United States Mint Pricing for 2012 Infantry Soldier Silver Dollar and 2012 Star- Spangled Banner... United States Mint is announcing adjusted pricing for the 2012 Infantry Soldier Silver Dollar and 2012.../A 53.95 Dollar Set The introductory pricing period for the 2012 Infantry Soldier Silver...

  13. Operational Performance of the U.S. 28th Infantry Division September to December 1944

    Science.gov (United States)

    1994-06-03

    8217 Ernest Hemingway During World War H, Ernest Hemingway served as a war correspondent in the ETO and frequently operated with the U.S. 4th Infantry...soldiers into cohesive units.9’ 103 Endntes 1. Ernest Hemingway , Personal notes while serving as a war correspondent with the U.S. 4th Infantry

  14. Reorganizing for Global War: General Malin Craig and the Triangular Infantry Division, 1935-1939

    Science.gov (United States)

    2014-05-22

    38Harry C. Ingles , “The New Division,” Infantry Journal 46, no. 6 (Nov-Dec 1939), 522; Wilson, 132. 26...1923), 1; Wilson, 127. 42Wilson, 129. Ingles , 522. 28 The Provisional Infantry Division...objections, however, the 43“Texas Preview,” Army and Navy, Time, November 22, 1937, 24; Ingles , 523. 29

  15. INFANTRY WEAPONS IN SOUTH AFRICA, 1652-1881

    Directory of Open Access Journals (Sweden)

    A.L.S. Hudson

    2012-02-01

    Full Text Available Lt Genl C. L. Viljoen, present Chief of the South African Army, describes the South African soldier in his forword to the book 'Our South African Army Today' as follows: 'Throughout history, soldiering has always come naturallY to South Africans. In many wars and battles [he South African soldier has proved himself .to be brave, determined and willing to sacrifice all for the cause.'1 It is a well establ ished fact that the infantry was and still is the nucleus of any army and was aptly described by SirWilliam Napier as the 'Queen of the Battlefield.'

  16. Infantry Instructors’ Conference. 15-19 July 1963

    Science.gov (United States)

    1963-01-01

    primary functions are of a logistical nature. Ocl PLAY SOT N *UnG XO HG CO 4ON LOG NCr g(voCC) VR .1 am.4 INXO OPY PLAT LDR MAINT OFF MAINT SOT $UP OFF 4...operating-in the Mediter - ranean, at Normandy, and in the Southwest Pacific. The concept during the Korean conflict was that of Ranger Infantry...trailers, two 3/4-ton 7 trucks with trailers, a- 1/4-toin truck with one AN/ VR -46 radio, and a 5-ton wrecker. The maintenance platoon of the mechanized

  17. FIREFORCE - ONE MAN'S WAR IN THE RHODESIAN LIGHT INFANTRY

    OpenAIRE

    Noëlle Van der Waag-Cowling

    2012-01-01

    "They have the faces of boys but they fight like lions" The history of the Rhodesian Light Infantry is an illustrious one. The RLI produced many of the senior brass who led the Rhodesian Army including Gen Peter Walls. It was arguably Rhodesia's premier fighting unit (if one excludes Rhodesia's two special forces outfits, the Special Air Service and the Selous Scouts). The spirit of the RLI runs deep in Rhodesian military lore, it was to all intents and purposes a unique Regiment. The RLI was...

  18. Moselle River Crossing. Offensive, River Crossing, 5th Infantry Division, September 1944

    Science.gov (United States)

    1983-05-20

    Canadian Army and the 2d British Army. The Canadian Army was driving towards the Belgian city of Bruge while the 2d British Army was moving towards...use "in the Atlantic Wall. An American legend often repeated in postwar unit histories was that the Germans had worked feverishly on the forts...Section, 10th Infantry Regiment. History of the Tenth L%, Infantry Regiment, US Army. 1946. •’ ( \\ Seaton, Albert. The Fall of Fortress Europe 1943

  19. The Twelve Hotel, Barna : Video

    OpenAIRE

    Irish Food Channel

    2014-01-01

    Fergus O'Halloran, Managing Director of The Twelve Hotel in Barna in County Galway, talks about his philosophy in running this unique boutique hotel. Reproduced with kind permission from John & Sally McKenna. 3.35 mins

  20. Modern night vision goggles for advanced infantry applications

    Science.gov (United States)

    Estrera, Joseph P.; Ostromek, Timothy E.; Isbell, Wayne; Bacarella, Antonio V.

    2003-09-01

    Northrop Grumman Electro-Optical Systems (NGEOS) has concentrated in recent years on the development of advanced night vision goggle (NVG) systems. These NVGs developments concentrate on past operational deficiencies such as high light/bright source conditions during military operations in urban terrain (MOUT), poor individual movement technique (IMT) infantry operations, and obscured battlefield and reduced weather conditions. The first area of NVG advancement involves direct image intensifier (I2) replacement involving automatic gated power supply technology for wide dynamic NVG operation and advanced Generation III halo free I2 technology for reduction of NVG image halo and "blooming" artifacts. The second significant development area is NVG individual movement technique (IMT) deficiencies such as reduced field of view, reduced depth perception, center of gravity problems, and limited operation flexibility. These issues of NVG IMT have resulted in the development of an IMT enhanced night vision goggle for the U.S. Army's enhanced night vision goggle (ENVG). Finally, Northrop Grumman EOS is developing a NVG with the capability of producing optimized real-time image fusion from an image intensified sensor and uncooled long wavelength infrared (LWIR) sensor. This new technology allows for optimum imaging in battlefield obscured and laser polluted environment. These image fusion NVG development efforts have concentrated on both optical overlay image fusion and digital image fusion. This paper will compare and contrast these two types of image fusion technologies.

  1. Quantizing Analysis and Processing of Test Conditions for Infantry Grenade Ignition Characteristics

    Institute of Scientific and Technical Information of China (English)

    SHAN Yong-hai; ZHANG Bing; SUN Guo-ji

    2005-01-01

    A rule of how the ignition probability or invalidation probability of infantry grenade varies with the projectile quantity is presented based on the statistical analysis. The statistical induction, quantizing analysis and data processing in the infantry grenade type approval test are completed, and we obtain how various test factors in the research item affect the test results(invalidation probability), i.e., quantized data. The acquisition of these quantized data provides theory basis and data auspice for further reasonable filtration of all test factors and the optimization of test scheme.

  2. 78 FR 24734 - Final Environmental Impact Statement for the Construction and Operation of an Infantry Platoon...

    Science.gov (United States)

    2013-04-26

    ...-HI) propose to construct and operate a modern Infantry Platoon Battle Course (IPBC) and associated infrastructure that is compliant with current Army training requirements at P hakuloa Training Area (PTA), Hawai... Reserve, and Hawai`i Army National Guard, as well as other Service components that are stationed or...

  3. 2005 International Infantry and Joint Services Small Arms Systems Annual Symposium Exhibition and Firing Demonstration

    Science.gov (United States)

    2005-05-19

    Raptor • Wolf Pack Infantry Weapons • Modular Weapon System (MWS) NBCS • NBC Equipment Operation Center • Portable Display Device • Digital Automated...capabilities? • What are the military’s requirements? • What is the military doing with ISNLS/blunt trauma ? – Qualification of existing commercial...Human Target/USER Effects – Non-lethality of Blunt Trauma •Compliance to Military conditions – MIL-STD 810F (Salt fog, drop testing, Sand & dust etc

  4. The 300th Infantry Division in Mius-Front Fights in February-March of 1943

    Directory of Open Access Journals (Sweden)

    Medvedev Maksim Valeryevich

    2015-11-01

    Full Text Available After the encirclement of the German troops and their allies near Stalingrad at the end of November, 1942, the Red army was able to develop large-scale offensive to the west. In January and in the beginning of February of 1943 the forces of the Southern front struck blow on the Rostov direction. This article is devoted to military operations of the 300th infantry division of the 13th Guard infantry corps of the 2nd Guards army at the beginning of 1943. Mentions of them are practically absent in a historiography. Meanwhile, in fights of February – the first decade of March, when the division has suffered huge losses and has been taken away in a reserve, are of great historic importance. In the Soviet historiography in days of the Great Patriotic War not enough attention was paid to destiny of separate fighting connections, the principal value was attached to actions of large expeditions and strategic military associations. It concerns also the 300th infantry division operating to Mius-fronte in February-March, 1943. Meanwhile, the appeal to its fighting way allows to understand better the reasons of failures of the Soviet approach, to find out in what conditions it passed. The approach of this division failed and brought big losses to staff and military equipment. Being guided by the declassified documents of the Central archive of the Ministry of Defence, the author discovers one of the little-known pages of the Mius-front history.

  5. Transanal rectopexy - twelve case studies

    Directory of Open Access Journals (Sweden)

    Rubens Henrique Oleques Fernandes

    2012-06-01

    Full Text Available OBJECTIVES: This study analyzed the results of transanal rectopexy and showed the benefits of this surgical technique. METHOD: Twelve patients were submitted to rectopexy between 1997 and 2011. The surgical technique used was transanal rectopexy, where the mesorectum was fixed to the sacrum with nonabsorbable suture. Three patients had been submitted to previous surgery, two by the Delorme technique and one by the Thiersch technique. RESULTS: Postoperative hospital stay ranged from 1 to 4 days. One patient (8.3% had intraoperative hematoma, which was treated with local compression and antibiotics. One patient (8.3% had residual mucosal prolapse, which was resected. Prolapse recurrence was seen in one case (8.3%. Improved incontinence occurred in 75% of patients and one patient reported obstructed evacuation in the first month after surgery. No death occurred. CONCLUSION: Transanal rectopexy is a simple, low cost technique, which has shown good efficacy in rectal prolapse control.OBJETIVO: O presente estudo analisou os resultados da retopexia pela via transanal e expôs os benefícios desta técnica cirúrgica. MÉTODO: Doze pacientes com prolapso foram operados no período de 1997 a 2011. A técnica cirúrgica usada foi a retopexia transanal, onde o mesorreto foi fixado ao sacro com fio inabsorvível. Três pacientes tinham cirurgia prévia, dois pela técnica de Delorme e um pela técnica de Thiersch. RESULTADOS: A permanência hospitalar pós-operatória variou de 1- 4 dias. Uma paciente (8,3% apresentou hematoma transoperatório que foi tratado com compressão local e antibioticoterapia. Um paciente apresentou prolapso mucoso residual (8,3%, que foi ressecado. Houve recidiva da procidência em um caso (8,3%. A melhora da incontinência ocorreu em 75% dos pacientes e uma paciente apresentou bloqueio evacuatório no primeiro mês após a cirurgia. Não houve mortalidade entre os pacientes operados. CONCLUSÃO: A retopexia transanal é uma t

  6. Twelve new species of Triplocania Roesler (Psocodea: 'Psocoptera': Ptiloneuridae), from South America.

    Science.gov (United States)

    Silva Neto, Alberto Moreira Da; Aldrete, Alfonso N García; Rafael, José Albertino

    2016-05-09

    Twelve species of Triplocania, seven based on male and female specimens and five based on male specimens, are here described and illustrated; nine species are Brazilian, three are Ecuadorian, and one of the latter is shared with Peru. Comments on sexes known and distribution of the species are included.

  7. Critical Combat Performances, Knowledges, and Skills Required of the Infantry Rifle Squad Leader: Human Maintenance under Campaign Conditions.

    Science.gov (United States)

    Brown, Frank L.; Jacobs, T. O.

    The paper covers the performances, skills, and kinds of knowledge demanded of an infantry rifle squad leader to maintain an organized and effective fighting unit under campaign conditions and to set an example as a leader for his men. It covers personal hygiene and field sanitation, the maintenance of minimal fighting and existence loads, water…

  8. Mythematics Solving the Twelve Labors of Hercules

    CERN Document Server

    Huber, Michael

    2009-01-01

    How might Hercules, the most famous of the Greek heroes, have used mathematics to complete his astonishing Twelve Labors? From conquering the Nemean Lion and cleaning out the Augean Stables, to capturing the Erymanthean Boar and entering the Underworld to defeat the three-headed dog Cerberus, Hercules and his legend are the inspiration for this book of fun and original math puzzles. While Hercules relied on superhuman strength to accomplish the Twelve Labors, Mythematics shows how math could have helped during his quest. How does Hercules defeat the Lernean Hydra and stop its heads from multip

  9. Comparative analysis of twelve Dothideomycete plant pathogens

    Energy Technology Data Exchange (ETDEWEB)

    Ohm, Robin; Aerts, Andrea; Salamov, Asaf; Goodwin, Stephen B.; Grigoriev, Igor

    2011-03-11

    The Dothideomycetes are one of the largest and most diverse groups of fungi. Many are plant pathogens and pose a serious threat to agricultural crops grown for biofuel, food or feed. Most Dothideomycetes have only a single host and related Dothideomycete species can have very diverse host plants. Twelve Dothideomycete genomes have currently been sequenced by the Joint Genome Institute and other sequencing centers. They can be accessed via Mycocosm which has tools for comparative analysis

  10. Where are the Infantry Sergeants? An Examination of the Marine Corps’ Policies and Processes That Adversely Affected the Availability of Infantry Sergeants to Serve as Squad Leaders in the Operating Forces

    Science.gov (United States)

    2009-01-01

    platoon broke down into two half platoons led by Sergeants. Lacldng their own tables or organization, Marine * Appendix C graphically depicts the Table...availability of infantry Sergeants. t Appendix C graphically depicts ,the Table of Organization of the US Marine Corps Rifle Company of 1944 8 h...affect enlisted ’staffing in recent conflicts. . Operation Desert Shielcl/ Deseli StC?rm was too brief to have had significant impact on manpower

  11. Design Considerations of a Lower Limb Exoskeleton System to Assist walking and Load-Carrying of Infantry Soldiers

    Directory of Open Access Journals (Sweden)

    Seungnam Yu

    2014-01-01

    Full Text Available This paper describes the development of a wearable exoskeleton system for the lower extremities of infantry soldiers and proposes appropriate design criteria based on existing case studies. Because infantry soldiers carry a variety of equipment, the interference with existing equipment and additional burden of the exoskeleton support system should be minimized. Recent studies have shown that a user only needs to be supported in the gravitational direction when walking on flat terrain; however, active joints are necessary to support walking over rough and sloped terrain such as mountains. Thus, an underactuated exoskeleton system was considered: passive joints are applied to the hip and ankle joints, and active joints are applied to the knee joints to exploit the dynamic coupling effect of the link structure and muscular activation patterns when the user is going up and down stairs. A prototype of the exoskeleton system was developed and validated through a simple stair-climbing experiment.

  12. Twelve tips for peer observation of teaching.

    Science.gov (United States)

    Siddiqui, Zarrin Seema; Jonas-Dwyer, Diana; Carr, Sandra E

    2007-05-01

    This paper outlines twelve tips for undertaking peer observation of teaching in medical education, using the peer review model and the experiences of the authors. An accurate understanding of teaching effectiveness is required by individuals, medical schools, and universities to evaluate the learning environment and to substantiate academic and institutional performance. Peer Observation of Teaching is one tool that provides rich, qualitative evidence for teachers, quite different from closed-ended student evaluations. When Peer Observation of Teaching is incorporated into university practice and culture, and is conducted in a mutually respectful and supportive way, it has the potential to facilitate reflective change and growth for teachers.

  13. Combining ability of twelve maize populations

    Directory of Open Access Journals (Sweden)

    Vacaro Elton

    2002-01-01

    Full Text Available Genetic progress depends on germplasm quality and breeding methods. Twelve maize populations and their crosses were evaluated to estimate combining ability and potential to be included as source populations in breeding programs. Plant height, point of insertion of the first ear, number of ears per plant, number of grains per ear, root and stalk lodging and grain yield were studied in two locations in Brazil, during the 1997/98 season. Genotype sum of squares was divided into general (GCA and specific (SCA combining ability. Results indicated the existence of genetic divergence for all traits analyzed, where additive effects were predominant. The high heterosis levels observed, mainly in Xanxerê, suggested the environmental influence on the manifestation of this genetic phenomenon. Populations revealed potential to be used in breeding programs; however, those more intensively submitted to selection could provide larger genetic progress, showing the importance of population improvement for the increment of the heterosis in maize.

  14. Seroconversion to Japanese Encephalitis Virus among U.S. Infantry Forces in Korea

    Science.gov (United States)

    Eick-Cost, Angelia A.; Hu, Zheng; Klein, Terry A.; Putnak, Robert J.; Jarman, Richard G.

    2015-01-01

    Japanese encephalitis virus (JEV) is endemic in the Republic of Korea (ROK), posing a medical threat to more than 29,000 U.S. Forces military personnel currently deployed in the ROK. The objective of this study was to provide data on the risk of JEV exposure among U.S. Forces in the ROK. One thousand U.S. Army Soldiers were randomly selected for the study from the cohort of infantry Soldiers deployed in the ROK for a period of at least 330 days from 2008 to 2011. Pre- and post-deployment serum specimens were tested for the presence of JEV antibodies by plaque reduction neutralization test. A total of 2/1,000 (0.2%) U.S. Army Soldiers post-deployment specimens tested positive for JEV antibody. Results from the pre-deployment specimens indicated one true seroconversion and one with titers suggestive of a JEV infection. These results indicate a low, but nonzero risk of JEV exposure among U.S. Army Soldiers in the ROK. PMID:26240157

  15. Twelve tips for getting your manuscript published.

    Science.gov (United States)

    Cook, David A

    2016-01-01

    The author shares twelve practical tips on how to navigate the process of getting a manuscript published. These tips, which apply to all fields of academic writing, advise that during the initial preparation phase authors should: (1) plan early to get it out the door; (2) address authorship and writing group expectations up front; (3) maintain control of the writing; (4) ensure complete reporting; (5) use electronic reference management software; (6) polish carefully before they submit; (7) select the right journal; and (8) follow journal instructions precisely. Rejection after the first submission is likely, and when this occurs authors should (9) get it back out the door quickly, but first (10) take seriously all reviewer and editor suggestions. Finally, when the invitation comes to revise and resubmit, authors should (11) respond carefully to every reviewer suggestion, even if they disagree, and (12) get input from others as they revise. The author also shares detailed suggestions on the creation of effective tables and figures, and on how to respond to reviewer critiques.

  16. Antifouling activity of twelve demosponges from Brazil

    Directory of Open Access Journals (Sweden)

    SM. Ribeiro

    Full Text Available Benthic marine organisms are constantly exposed to fouling, which is harmful to most host species. Thus, the production of secondary metabolites containing antifouling properties is an important ecological advantage for sessile organisms and may also provide leading compounds for the development of antifouling paints. High antifouling potential of sponges has been demonstrated in the Indian and Pacific oceans and in the Caribbean and Mediterranean seas. Brazilian sponges remain understudied concerning antifouling activities. Only two scientific articles reported this activity in sponges of Brazil. The objective of this study was to test crude extracts of twelve species of sponges from Brazil against the attachment of the mussel Perna perna through laboratorial assays, and highlight promising species for future studies. The species Petromica citrina, Amphimedon viridis, Desmapsamma anchorata, Chondrosia sp., Polymastia janeirensis, Tedania ignis, Aplysina fulva, Mycale angulosa, Hymeniacidon heliophila, Dysidea etheria, Tethya rubra, and Tethya maza were frozen and freeze-dried before extraction with acetone or dichloromethane. The crude extract of four species significantly inhibited the attachment of byssus: Tethya rubra (p = 0.0009, Tethya maza (p = 0.0039, Petromica citrina (p = 0.0277, and Hymeniacidon heliophila (p = 0.00003. These species, specially, should be the target of future studies to detail the substances involved in the ability antifouling well as to define its amplitude of action.

  17. Twelve Elastic Constants of Betula platyphylla Suk.

    Institute of Scientific and Technical Information of China (English)

    Wang Liyu; Lu Zhenyou

    2004-01-01

    Wood elastic constants are needed to describe the elastic behaviors of wood and be taken as an important design parameter for wood-based composite materials and structural materials. This paper clarified the relationships between compliance coefficients and engineering elastic constants combined with orthotropic properties of wood, and twelve elastic constants of Betula platyphylla Suk. were measured by electrical strain gauges. Spreading the adhesive quantity cannot be excessive or too little when the strain flakes were glued. If excessive, the glue layer was too thick which would influence the strain flakes' performance, and if too little, glues plastered were not firm, which could not accurately transmit the strain. Wood as an orthotropic material, its modulus of elasticity and poisson's ratios are related by two formulas:μij /Ei =μji /Ej and μij 0.95) between the reciprocal of elastic modulus MOE-1 and the square of the ratio of depth to length (h/l)2, which indicate that shear modulus values measured were reliable by three point bending experiment.

  18. [Twelve years of working of Brazzaville cancer registry].

    Science.gov (United States)

    Nsondé Malanda, Judith; Nkoua Mbon, Jean Bernard; Bambara, Augustin Tozoula; Ibara, Gérard; Minga, Benoît; Nkoua Epala, Brice; Gombé Mbalawa, Charles

    2013-02-01

    The Brazzaville cancer registry was created in 1996 with the support of the International Agency Research against Cancer (IARC) which is located in Lyon, France. The Brazzaville cancer registry is a registry which is based on population which records new cancer cases occurring in Brazzaville by using Canreg 4.0 Software. Its aim is to supply useful information to fight against cancer to physicians and to decision makers. We conducted this study whose target was to determine the incidence of cancer in Brazzaville during twelve years, from January 1st, 1998 to December 31, 2009. During that period 6,048 new cancer cases were recorded: 3,377 women (55.8%), 2,384 men (39.4%), and 287 children (4.8%) from 0 to 14 years old with an annual average of 504 cases. Middle age to the patient's diagnosis was 49.5 years in female sex and 505.5 years old for male sex. The incidence rate of cancers in Brazzaville was 39.8 or 100.000 inhabitants per year and by sex we observed 49 to female sex and 35.2 for male sex. The first cancers localizations observed to women were in order of frequency: breast, cervix uterine, liver ovaries, hematopoietic system, to men : liver, prostate, hematopoietic system, colon and stomach; to children : retina, kidney, hematopoietic system, liver and bones. These rates are the basis to know the burden of cancer among all pathologies of Brazzaville and the achievement of a national cancer control program.

  19. Hepatic Angiosarcoma: a Review of Twelve Cases

    Institute of Scientific and Technical Information of China (English)

    Qiang Li; Xishan Hao

    2005-01-01

    OBJECTIVE Hepatic angiosarcoma (HAS), a lethal disease, is the most common sarcoma arising in the liver. Little information about the epidemiology, etiology, diagnosis and management of HAS has been reported. Increased familiarity with this disease will facilitate correct diagnosis and help to improve management of this condition in the future.The objective of this study was to describe cases of hepatic angiosarcoma and to discuss the etiologic, diagnostic, therapeutic features and prognosis of this tumor. This report not only serves to give more evidence of the relationship between hepatic angiosarcoma and carcinogenic exposure, but also demonstrates the key points in different methods of diagnosis and the optimal treatment of hepatic angiosarcoma.METHODS Twelve cases of hepatic angiosareoma were analyzed retrospectively, representing the different character in clinical presentations and laboratory computed tomographical scans; pathological data and treatment are described. Clinical and biologic follow-up was carried out for two years after surgical treatment.RESULTS There were nine men and three women varying in ages from 57 to 71 years with an average of 64.3 years. Ten patientshad a history of exposure to vinyl chloride or thorotrast. Mild or moderate abdominal pain and bloating, abdominal mass and fever were the common clinical presentations. Tumors were visualized by ultrasonography and CT scans in all patients. Biochemical profiles yielded variable results and proved to be of little value in detection or diagnosis. Surgical resection was feasible for each patient who was treated as follows: two wedge resections, six segementectomies and four bisegmentectomies. Five patients received Neoadjuvant chemotherapy postoperatively. The survival rate of those cases was poor. The maximum survival time was fourteen months. The mean survival time for this chemotherapeutic group was 11 months. The difference between the survival time of those treated with an operation

  20. One Tank, 31 Boxes of .50 Cal. and 11 Men: An Analysis of the Armor- Infantry Team in Korea, June 1950 - July 1952

    Science.gov (United States)

    1989-06-02

    company. The logic behind this decision was best summarized by Major General Kibler at a conference on the infantry division given at the Grand Hotel...Joe Offutt 4005 Esperanza Drive El Paso, Texas 79922 6. CSM Billy Gray 1428 Server Drive Colorado Springs, Colorado 30910 -142-

  1. Photographs of the 369th Infantry and African Americans during World War I. The Constitution Community: The Emergence of Modern America (1890-1930).

    Science.gov (United States)

    Schur, Joan Brodsky

    In April 1917, President Woodrow Wilson asked Congress to declare war on Germany. Under the powers granted to it by the U.S. Constitution, Congress passed the Selective Service Act of 1917. Among the first regiments to arrive in France, and among the most highly decorated when it returned, was the 369th Infantry, more gallantly known as the…

  2. Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.

    Science.gov (United States)

    De Lonlay, P; Benelli, C; Fouque, F; Ganguly, A; Aral, B; Dionisi-Vici, C; Touati, G; Heinrichs, C; Rabier, D; Kamoun, P; Robert, J J; Stanley, C; Saudubray, J M

    2001-09-01

    Hyperinsulinism and hyperammonemia syndrome has been reported as a cause of moderately severe hyperinsulinism with diffuse involvement of the pancreas. The disorder is caused by gain of function mutations in the GLUD1 gene, resulting in a decreased inhibitory effect of guanosine triphosphate on the glutamate dehydrogenase (GDH) enzyme. Twelve unrelated patients (six males, six females) with hyperinsulinism and hyperammonemia syndrome have been investigated. The phenotypes were clinically heterogeneous, with neonatal and infancy-onset hypoglycemia and variable responsiveness to medical (diazoxide) and dietary (leucine-restricted diet) treatment. Hyperammonemia (90-200 micromol/L, normal carbamylglutamate administration. The patients had mean basal GDH activity (18.3 +/- 0.9 nmol/min/mg protein) not different from controls (17.9 +/- 1.8 nmol/min/mg protein) in cultured lymphoblasts. The sensitivity of GDH activity to inhibition by guanosine triphosphate was reduced in all patient lymphoblast cultures (IC(50), or concentrations required for 50% inhibition of GDH activity, ranging from 140 to 580 nM, compared with control IC(50) value of 83 +/- 1.0 nmol/L). The allosteric effect of ADP was within the normal range. The activating effect of leucine on GDH activity varied among the patients, with a significant decrease of sensitivity that was correlated with the negative clinical response to a leucine-restricted diet in plasma glucose levels in four patients. Molecular studies were performed in 11 patients. Heterozygous mutations were localized in the antenna region (four patients in exon 11, two patients in exon 12) as well as in the guanosine triphosphate binding site (two patients in exon 6, two patients in exon 7) of the GLUD1 gene. No mutation has been found in one patient after sequencing the exons 5-13 of the gene.

  3. Premarital Sex in the Last Twelve Months and Its Predictors among Students of Wollega University, Ethiopia.

    Science.gov (United States)

    Regassa, Tesfaye; Chala, Dereje; Adeba, Emiru

    2016-07-01

    Premarital sex increases the risk of unintended pregnancy and sexually transmitted infections including HIV if unprotected and contraception is not used. Thus, the objective of this study was to assess premarital sex in the last twelve months and its predictors among regular undergraduate students of Wollega University. A cross-sectional survey using pretested, structured questionnaire was conducted on a total of 704 regular undergraduate students of Wollega University from February to March, 2014. We used multistage sampling technique to recruit study participants. Binary and multivariable logistic regressions were performed using SPSS version 20 to assess predictors of premarital sex. Statistical significance was determined through a 95% confidence level. Wollega University youths who had premarital sex in the last twelve months were 28.4%; 55.5% of them did not use condom during last sex while 31.3% engaged in multiple sex. Being male [Adjusted Odds Ratio (AOR)(95% Confidence Interval(CI))=2.7(1.58-4.75)], age 20-24 years [AOR(95%CI)=2.8(1.13-7.20)], training on how to use condom [AOR(95%CI)=1.7(1.17-2.46)], being tested for HIV [AOR(95%CI)=2.3(1.48-3.53)], using social media frequently [AOR(95%CI)=1.8(1.14-2.88)], having comprehensive knowledge of HIV [AOR(95% CI)=1.5(1.01-2.10)], alcohol use [AOR (95%CI)=2.2(1.31-3.56)] were associated with increased odds of premarital sex in the last twelve months. Nearly one-third of regular undergraduate students of the university were engaged in premarital sex in the last twelve months. Being male, using social media frequently and alcohol use were associated with increased odds of premarital sex in the stated period. Thus, higher institutions have to deliver abstinence messages alongside information about self-protection.

  4. A Learning Organization Born in the Crucible of Combat: The 3rd Infantry Brigade, 2nd Division, in World War I

    Science.gov (United States)

    2016-06-10

    division was expected to fight and were, figuratively speaking , students under Lejeune’s tutelage. This is important because the new commanders...Organization. The skillful practice of personal mastery, challenging mental models, creating a shared vision, fostering team learning and developing...organization. In the end, the 3rd Infantry Brigade demonstrated personal mastery of warfighting skills , challenged the status quo of their doctrine

  5. The twelve dimensional super (2+2)-brane

    CERN Document Server

    Hewson, S F

    1996-01-01

    We discuss supersymmetry in twelve dimensions and present a covariant supersymmetric action for a brane with worldsheet signature (2,2), called a super (2+2)-brane, propagating in the osp(64,12) superspace. This superspace is explicitly constructed, and is trivial in the sense that the spinorial part is a trivial bundle over spacetime, unlike the twisted superspace of usual Poincare supersymmetry. For consistency, it is necessary to take a projection of the superspace. This is the same as the projection required for worldvolume supersymmetry. Upon compactification of this superspace, a torsion is naturally introduced and we produce the membrane and type IIB string actions in 11 and 10 dimensional Minkowski spacetimes. In addition, the compactification of the twelve dimensional supersymmetry algebra produces the correct algebras for these theories, including central charges. These considerations thus give the type IIB string and M-theory a single twelve dimensional origin.

  6. Alcoholics anonymous and other twelve-step programs in recovery.

    Science.gov (United States)

    Detar, D Todd

    2011-03-01

    Recovery is a new way of life for many patients; a life without substances to alter their moods but with a major change improving the physical, psychological, and emotional stability with improved overall health outcomes. The Twelve Steps of the Alcoholics Anonymous (AA) are the foundation of the AA, describing both the necessary actions and the spiritual basis for the recovery program of the AA. The Twelve Steps of the AA provide a structure for which a patient with alcoholism may turn for an answer to their problem of alcohol use, abuse, or dependence. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Vitamin and mineral intake of twelve adolescent male Kalenjin runners in western Kenya

    DEFF Research Database (Denmark)

    Christensen, Dirk Lund; Jakobsen, Jette; Friis, H

    2005-01-01

    , and niacin all met RSDI by 208%, 107%, and 131%, respectively. Similarly, the intakes of magnesium, iron, and zinc were 272%, 404%, and 122% of RSDI, respectively, while calcium and selenium were below, 47% and 49%, respectively. The daily intakes of phosphorous, copper, and chromium were estimated to 4214...

  8. The strong coupling regime of twelve flavors QCD

    NARCIS (Netherlands)

    Silva, Tiago Nunes da; Pallante, Elisabetta

    2012-01-01

    We summarize the results recently reported in Ref.[1] [A. Deuzeman, M.P. Lombardo, T. Nunes da Silva and E. Pallante,"The bulk transition of QCD with twelve flavors and the role of improvement"] for the SU(3) gauge theory with Nf=12 fundamental flavors, and we add some numerical evidence and theoret

  9. EFFORTS Technical annex for the twelve month progress report

    DEFF Research Database (Denmark)

    Andreasen, Jan Lasson; Eriksen, Morten; Thomas christensen, Thomas Vennick;

    The present report is documentation for the work carried out at DTU during the second year of project activity. The report describes the work completed by DTU in general as well as on the active sub-tasks within materials properties, friction modelling and physical modelling, over the last twelve...

  10. Human Evolution in Science Textbooks from Twelve Different Countries

    Science.gov (United States)

    Quessada, Marie-Pierre; Clement, Pierre; Oerke, Britta; Valente, Adriana

    2008-01-01

    What kinds of images of human beings illustrate human evolution in school textbooks? A comparison between the textbooks of eighteen different countries (twelve European countries and six non-European countries) was attempted. In six countries (Algeria, Malta, Morocco, Mozambique, Portugal, and Tunisia), we did not find any chapter on the topic of…

  11. Bibliography of Spanish Materials for Students, Grades Seven through Twelve.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    This annotated bibliography of Spanish materials for students in grades seven through twelve is divided into the following categories: (1) Art, Drama, Music, and Poetry; (2) Books in Series; (3) Culture; (4) Dictionaries and Encyclopedias; (5) Literature; (6) Mathematics; (7) Physical Education, Health, and Recreation; (8) Reading and Language…

  12. Twelve Theses on Reactive Rules for the Web

    OpenAIRE

    Bry, François; Eckert, Michael

    2007-01-01

    Reactivity, the ability to detect and react to events, is an essential functionality in many information systems. In particular, Web systems such as online marketplaces, adaptive (e.g., recommender) sys- tems, and Web services, react to events such as Web page updates or data posted to a server. This article investigates issues of relevance in designing high-level programming languages dedicated to reactivity on the Web. It presents twelve theses on features desira...

  13. The twelve theses: a call to a new reformation

    Directory of Open Access Journals (Sweden)

    John Shelby Spong

    2015-03-01

    Full Text Available With every discovery emerging from the world of science over the last 500 years concerning the origins of the universe and of life itself, the traditional explanations offered by the Christian Church appeared to be more and more dated and irrelevant.  Christian leaders, unable to embrace the knowledge revolution seemed to believe  that the only way to save Christianity was not to disturb the old patterns either by listening to, much less by entertaining the new knowledge. I tried to articulate this challenge in a book entitled: Why Christianity Must Change or Die, published in 1998.  In that book I examined in detail the issues that I was convinced Christianity must address. Shortly after that book was published I reduced its content to twelve theses, which I attached in Luther-like fashion to the great doors on the Chapel of Mansfield College at Oxford University in the United Kingdom. I then mailed copies of those Twelve Theses to every acknowledged Christian leader of the world. It was an attempt to call them into a debate on the real issues that I was certain the Christian Church now faced.  I framed my twelve theses in the boldest, most provocative language possible, designed primarily to elicit response and debate. I welcome responses from Christians everywhere.  I claim no expertise or certainty in developing answers, but I am quite confident that I do understand the problems we are facing as Christians who are seeking to relate to the 21st century.

  14. Twelve tips for teaching medical students with dyslexia.

    Science.gov (United States)

    Shaw, Sebastian Charles Keith; Anderson, John Leeds

    2017-07-01

    Dyslexia is a common learning difficulty. As a result of SS' own experiences as a medical student with dyslexia, we have been researching and teaching on this topic for the past two years. Here, we present twelve tips for teaching medical students with dyslexia. These are gathered from our personal experiences and research, discussions with other educators, and wider literature on the topic. This article aims to shed some light on dyslexia, and also to make practical suggestions. Teaching students with dyslexia should not be a daunting experience. Small changes to existing methods, at minor effort, can make a difference - for example, adding pastel colors to slide backgrounds or avoiding Serif fonts. These tips can help educators gain more insight into dyslexia and incorporate small, beneficial adaptations into their teaching.

  15. Antibacterial activities of extracts from twelve Centaurea species from Turkey

    Directory of Open Access Journals (Sweden)

    Tekeli Yener

    2011-01-01

    Full Text Available Members of the genus Centaurea (Asteraceae have been used in traditional plant-based medicine. The methanol extracts of twelve Centaurea species, of which five are endemic to Turkey flora, were screened for antibacterial activity against four bacteria (Escherichia coli, Bacillus cereus, Salmonella enteritidis, Staphylococcus aureus. The antibacterial activity was evaluated by the microdilution method and the minimum inhibition concentrations (MIC of the extracts were determined. C. cariensis subsp. microlepis exhibited an antimicrobial effect on all tested microorganisms. The extracts from eight Centaurea species (C. balsamita, C. calolepis, C. cariensis subsp. maculiceps, C. cariensis subsp. microlepis, C. kotschyi var. kotschyi, C. solstitialis subsp. solstitialis, C. urvillei subsp. urvillei and C. virgata possessed antibacterial activity against several of the tested microorganisms.

  16. Twelve tips on how to compile a medical educator's portfolio.

    Science.gov (United States)

    Dalton, Claudia Lucy; Wilson, Anthony; Agius, Steven

    2017-09-17

    Medical education is an expanding area of specialist interest for medical professionals. Whilst most doctors will be familiar with the compilation of clinical portfolios for scrutiny of their clinical practice and provision of public accountability, teaching portfolios used specifically to gather and demonstrate medical education activity remain uncommon in many non-academic settings. For aspiring and early career medical educators in particular, their value should not be underestimated. Such a medical educator's portfolio (MEP) is a unique compendium of evidence that is invaluable for appraisal, revalidation, and promotion. It can stimulate and provide direction for professional development, and is a rich source for personal reflection and learning. We recommend that all new and aspiring medical educators prepare an MEP, and suggest twelve tips on how to skillfully compile one.

  17. Spectroscopy of twelve Type Ia supernovae at intermediate redshift

    CERN Document Server

    Balland, C; Pain, R; Walton, N A; Amanullah, R; Astier, Pierre; Ellis, Richard S; Fabbro, S; Goobar, A; Hardin, D; Hook, I M; Irwin, M J; McMahon, R M; Mendez, J M; Ruiz-Lapuente, P; Sainton, G; Schahmaneche, K; Stanishev, V

    2005-01-01

    We present spectra of twelve Type Ia supernovae obtained in 1999 at the William Herschel Telescope and the Nordic Optical Telescope during a search for Type Ia supernovae (SN Ia) at intermediate redshift. The spectra range from z=0.178 to z=0.493, including five high signal-to-noise ratio SN Ia spectra in the still largely unexplored range 0.15 < z < 0.3. Most of the spectra were obtained before or around restframe B-band maximum light. None of them shows the peculiar spectral features found in low-redshift over- or under-luminous SN Ia. Expansion velocities of characteristic spectral absorption features such as SiII at 6355 angs., SII at 5640 angs. and CaII at 3945 angs. are found consistent with their low-z SN Ia counterparts.

  18. Twelve novel Atm mutations identified in Chinese ataxia telangiectasia patients.

    Science.gov (United States)

    Huang, Yu; Yang, Lu; Wang, Jianchun; Yang, Fan; Xiao, Ying; Xia, Rongjun; Yuan, Xianhou; Yan, Mingshan

    2013-09-01

    Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized mainly by progressive cerebellar ataxia, oculocutaneous telangiectasia, and immunodeficiency. This disease is caused by mutations of the ataxia telangiectasia mutated (Atm) gene. More than 500 Atm mutations that are responsible for A-T have been identified so far. However, there have been very few A-T cases reported in China, and only two Chinese A-T patients have undergone Atm gene analysis. In order to systemically investigate A-T in China and map their Atm mutation spectrum, we recruited eight Chinese A-T patients from six unrelated families nationwide. Using direct sequencing of genomic DNA and the multiplex ligation-dependent probe amplification, we identified twelve pathogenic Atm mutations, including one missense, four nonsense, five frameshift, one splicing, and one large genomic deletion. All the Atm mutations we identified were novel, and no homozygous mutation and founder-effect mutation were found. These results suggest that Atm mutations in Chinese populations are diverse and distinct largely from those in other ethnic areas.

  19. Oral papillary squamous cell carcinoma in twelve dogs.

    Science.gov (United States)

    Nemec, A; Murphy, B G; Jordan, R C; Kass, P H; Verstraete, F J M

    2014-01-01

    Papillary squamous cell carcinoma (PSCC) is a distinct histological subtype of oral squamous cell carcinoma (SCC), described in both dogs and man. In dogs, PSCC has long been considered a malignant oral tumour of very young animals, but it has recently been reported to occur in adult dogs as well. The aim of this study was to describe the major clinicopathological characteristics of canine oral PSCC (COPSCC). Twelve dogs diagnosed with COPSCC were included in this retrospective study (1990-2012). The majority (75%) of the dogs were >6 years of age (median age 9 years). All tumours were derived from the gingiva of dentate jaws, with 66.7% affecting the rostral aspects of the jaws. The gross appearance of the lesions varied, with one having an intraosseous component only. The majority (91.7%) of the tumours were advanced lesions (T2 and T3), but no local or distant metastases were noted. Microscopically, two patterns were seen: (1) invasion of bone forming a cup-shaped indentation in the bone or a deeply cavitating cyst within the bone (cavitating pattern), (2) histologically malignant growth, but lack of apparent bone invasion (non-cavitating pattern). The microscopical appearance corresponded to imaging findings in a majority of cases, with cavitating forms presenting with a cyst-like pattern of bone loss or an expansile mass on imaging and non-cavitating forms showing an infiltrative pattern of bone destruction on imaging. These features suggest two distinct biological behaviours of COPSCC.

  20. Sensitivity and growth of twelve Elatior begonia cultivars to ozone

    Energy Technology Data Exchange (ETDEWEB)

    Reinert, R.A.; Nelson, P.V.

    1979-12-01

    Twelve cultivars of Elatior begonia (Begonia X hiemalis Fotsch.) were exposed to O/sub 3/ at 25 and 50 pphM. The 'Schwabenland' group, 'Whisper 'O' Pink', and 'Improved Krefeld Orange' were the most sensitive, whereas 'Ballerina', 'Mikkell Limelight', and 'Turo' were the least sensitive. 'Rennaisance', 'Heirloom' 'Nixe', and 'Fantasy' were intermediate in sensitivity. The dry weight of foliage (stems plus leaves) of 9 cultivars exposed to O/sub 3/ was significantly less than that of control plants. Ozone at 25 and 50 pphM inhibited flower growth (including peduncles) and development in 4 and 8 of the 12 cultivars, respectively. Differences in flower weight ranged from 43 to 105% of the control at 25 pphM and from 25 to 98% of the control at 50 pphM, depending on cultivar. 1 table.

  1. Twelve tips for designing and running longitudinal integrated clerkships.

    Science.gov (United States)

    Ellaway, Rachel; Graves, Lisa; Berry, Sue; Myhre, Doug; Cummings, Beth-Ann; Konkin, Jill

    2013-12-01

    Longitudinal integrated clerkships (LICs) involve learners spending an extended time in a clinical setting (or a variety of interlinked clinical settings) where their clinical learning opportunities are interwoven through continuities of patient contact and care, continuities of assessment and supervision, and continuities of clinical and cultural learning. Our twelve tips are grounded in the lived experiences of designing, implementing, maintaining, and evaluating LICs, and in the extant literature on LICs. We consider: general issues (anticipated benefits and challenges associated with starting and running an LIC); logistical issues (how long each longitudinal experience should last, where it will take place, the number of learners who can be accommodated); and integration issues (how the LIC interfaces with the rest of the program, and the need for evaluation that aligns with the dynamics of the LIC model). Although this paper is primarily aimed at those who are considering setting up an LIC in their own institutions or who are already running an LIC we also offer our recommendations as a reflection on the broader dynamics of medical education and on the priorities and issues we all face in designing and running educational programs.

  2. Commercializing Government-sponsored Innovations: Twelve Successful Buildings Case Studies

    Science.gov (United States)

    Brown, M. A.; Berry, L. G.; Goel, R. K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies.

  3. The strong coupling regime of twelve flavors QCD

    CERN Document Server

    da Silva, Tiago Nunes

    2012-01-01

    We summarize the results recently reported in Ref.[1] [A. Deuzeman, M.P. Lombardo, T. Nunes da Silva and E. Pallante,"The bulk transition of QCD with twelve flavors and the role of improvement"] for the SU(3) gauge theory with Nf=12 fundamental flavors, and we add some numerical evidence and theoretical discussion. In particular, we study the nature of the bulk transition that separates a chirally broken phase at strong coupling from a chirally restored phase at weak coupling. When a non-improved action is used, a rapid crossover is observed at small bare quark masses. Our results confirm a first order nature for this transition, in agreement with previous results we obtained using an improved action. As shown in Ref.[1], when improvement of the action is used, the transition is preceded by a second rapid crossover at weaker coupling and an exotic phase emerges, where chiral symmetry is not yet broken. This can be explained [1] by the non hermiticity of the improved lattice Transfer matrix, arising from the c...

  4. The Synthesis and Antitumor Activity of Twelve Galloyl Glucosides

    Directory of Open Access Journals (Sweden)

    Chang-Wei Li

    2015-01-01

    Full Text Available Twelve galloyl glucosides 1–12, showing diverse substitution patterns with two or three galloyl groups, were synthesized using commercially available, low-cost D-glucose and gallic acid as starting materials. Among them, three compounds, methyl 3,6-di-O-galloyl-α-D-glucopyranoside (9, ethyl 2,3-di-O-galloyl-α-D-glucopyranoside (11 and ethyl 2,3-di-O-galloyl-β-D-glucopyranoside (12, are new compounds and other six, 1,6-di-O-galloyl-β-D-glucopyranose (1, 1,4,6-tri-O-galloyl-β-D-glucopyranose (2, 1,2-di-O-galloyl-β-D-glucopyranose (3, 1,3-di-O-galloyl-β-D-glucopyranose (4, 1,2,3-tri-O-galloyl-α-D-glucopyranose (6 and methyl 3,4,6-tri-O-galloyl-α-D-glucopyranoside (10, were synthesized for the first time in the present study. In in vitro MTT assay, 1–12 inhibited human cancer K562, HL-60 and HeLa cells with inhibition rates ranging from 64.2% to 92.9% at 100 μg/mL, and their IC50 values were determined to be varied in 17.2–124.7 μM on the tested three human cancer cell lines. In addition, compounds 1–12 inhibited murine sarcoma S180 cells with inhibition rates ranging from 38.7% to 52.8% at 100 μg/mL in the in vitro MTT assay, and in vivo antitumor activity of 1 and 2 was also detected in murine sarcoma S180 tumor-bearing Kunming mice using taxol as positive control.

  5. Commercializing government-sponsored innovations: Twelve successful buildings case studies

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.; Berry, L.G.; Goel, R.K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies. 27 refs., 21 figs., 4 tabs.

  6. Soviet Naval Infantry

    Science.gov (United States)

    1977-06-10

    many ways was a self-made hero. He took the title of Generalissimo, a rank one step above IPrit urd, op. cit., p. 256. 2Msam ezw (Red Stir), 24 July...respective fleet headquarters. 3 Ibid. 4Kenneth R. hliting, Develog1 ent of the Soviet Armed Forces. 1917- SAir University Study No. AU-201-72- 1D , Mxwell

  7. Male Infertility

    Science.gov (United States)

    ... the urethra. Chromosome defects. Inherited disorders such as Klinefelter's syndrome — in which a male is born with ... or major abdominal or pelvic surgery Having a history of undescended testicles Being born with a fertility ...

  8. Male sexuality.

    Science.gov (United States)

    Ginsberg, Terrie B

    2010-05-01

    It should be recognized that sexuality in the aging male is of such import that a complete sexual history must be performed. By taking a complete sexual history, facts can be obtained that will allow for appropriate focus relating to a holistic evaluation and will enable us to dispel antiquated sexual myths pertaining to the aging male. If initiated by the history taker, questions concerning sexuality may be discussed more comfortably by the patient. Erectile dysfunction, male sexual response cycle, testosterone, sexually transmitted diseases, human immunodeficiency virus, long-term illness, along with religion and culture are explored in this article with the aim of improving one's knowledge base, self reflection, and awareness of the importance of male sexuality. A complete understanding and appreciation of the aging male's medical history, surgical history, social history, and emotional history as well as his sexual, cultural, and religious concepts will allow the health care provider to better analyze information, and to recommend and provide appropriate advice and treatment to the aging male patient.

  9. Splenic tuberculosis. Report of twelve cases; La tuberculose splenique

    Energy Technology Data Exchange (ETDEWEB)

    Adil, A.; Chikhaoui, N.; Ousehal, A.; Kadiri, R. [Centre Hospitalier Universitaire Ibn Rochd, Casablanca (Morocco)

    1995-12-31

    Tuberculosis of the spleen is not exceptional. The authors report ten cases which occurred with a predominance in young male adults. All patients had at least one other site of tuberculosis without any HIV infection. All patients had focal splenic lesions in the form of scattered hypo-echogenic and hypodense nodules. These nodules had a pseudo-tumor appearance in one case. CT-guided puncture was performed in one case. Splenic tuberculosis is not as rare as is sometimes thought. The CT-guided splenic puncture is now performed routinely and remains the ideal diagnostic approach. (authors). 9 refs., 5 figs.

  10. An Experiment in Humanistic Management within Community College District Twelve, Centralia/Olympia, Washington.

    Science.gov (United States)

    Miller, Dale A.; Hurley, John A.

    Community College District Twelve, a multi-college district serving a two-county area in southwestern Washington, has attempted to incorporate at administrative levels many of the humanistic, process-oriented principles of management discussed by Maslow and Maccoby. A concept of the ideal leadership style for District Twelve guides the selection…

  11. Nutrient Contents per Serving of Twelve Varieties of Cooked Rice Marketed in Jordan

    Directory of Open Access Journals (Sweden)

    Jafar M. El-Qudah

    2008-01-01

    Full Text Available Jordan imports rice from different countries without any quality preferences. Twelve varieties of cooked rice marketed in Jordan were analyzed. The content per serving of these varieties were computed for energy, protein, carbohydrates, fat, calcium, sodium, potassium, magnesium, manganese, copper, iron and phosphorous. The protein content per serving found to range from 0.49 g for La Cigala rice to 6.2 g for Harvest rice. The fat content for all rice brands was less than 0.37 g per serving. The energy content ranged from 172.12 g/serving for Basmati rice to 212.25 g/serving for Sun White rice. Generally, all rice varieties contain significant amounts of minerals per serving. Ruzzana found to contain the highest level of calcium (38.2 mg/serving and Amber the lowest calcium content (6.7 mg/serving. Magnesium content found to range from 5.7 mg/serving for Royal Umberella rice to 16.3 mg/serving for Ruzzana rice. Consumption of one serving of Harvest cooked rice will cover 13.5% of the daily requirement of protein for females and 11.1% for males. Manganese content of one serving of Harvest, Sun White, Abu bent and La Cigala will cover 22.2% of the daily requirements for females and 14.7% for males, while consumption of one of Basmati, Sos rice or Amber will cover only 11.1% and 8.75 of requirement for females and males respectively. Planning a healthful diet is not a simple task. Dietary Reference Intake planning and assessing the diets of individuals or groups of healthy individuals according to their stage of life and sex. Food choice is a function of many factors, including personal preferences, habits, ethnic heritage and tradition. Dietary guidelines for Americans, consider whole grain products like rice are among the food groups that form the basis of a healthy diet. Including rice as part of a healthy, balanced diet can be linked to overall healthier eating patterns. Rice eaters are more likely to eat a diet consistent with the 2005 Dietary

  12. Male Hypogonadism

    Science.gov (United States)

    ... types of male hypogonadism can be treated with testosterone replacement therapy. Symptoms Hypogonadism can begin during fetal development, before puberty or during adulthood. Signs and symptoms depend on when the condition ... enough testosterone during fetal development, the result may be impaired ...

  13. The impact of alcoholics anonymous on other substance abuse-related twelve-step programs.

    Science.gov (United States)

    Laudet, Alexandre B

    2008-01-01

    This chapter explores the influence of the AA model on self-help fellowships addressing problems of drug dependence. Fellowships that have adapted the twelve-step recovery model to other substances of abuse are reviewed; next similarities and differences between AA and drug-recovery twelve-step organizations are examined; finally, we present empirical findings on patterns of attendance and perceptions of AA and Narcotics Anonymous (NA) among polydrug-dependent populations, many of whom are cross-addicted to alcohol. Future directions in twelve-step research are noted in closing.

  14. The Military Route of 24 th Infantry Division within the Troops of North-Western, Western and Northern Fronts. 1914–1917

    Directory of Open Access Journals (Sweden)

    Mikhaylov Andrey

    2014-11-01

    Full Text Available The article presents the operational record of 24th infantry division during the First World War within the troops of three fronts (North-Western, Northern and Western. This division was formed in 1863, and in 1892-1895 three of its four regiments were located in Pskov, an old city in the North-West of Russia. The officer staff (their social origin and education by the eve of the First World War as well as the mobilization course at the beginning of the War have been reviewed in the article. On the example of one military unit, typical of the Russian Army, the author analyzes the peculiar features of military operations during the First World War and the role of the division’s participation in several major operations in 1914-1917. They include the Russian Army’s dramatic offensive in East Prussia (summer and autumn 1914, the defensive fighting on the Ravca river (in the beginning of 1915, the offensive of the Russian army in Galicia in 1916 (known as Brusilov Offensive. The article has been finished with the story about the division’s way during the Russian Army’s disintegration in the period of the revolution of 1917. The article is based on the unpublished documents from Russian Military and Historic Archive (Moscow as well as on the press materials.

  15. CLINICAL APPLICATION OF “TWELVE WELL-POINTS” IN EMERGENCY TREATMENT

    Institute of Scientific and Technical Information of China (English)

    段功保

    2000-01-01

    In many years' clinical practice, I used blood-letting method of “Twelve Well-points” to treat emergencies as coma, syncope, acute infantile convulsion, wind-stroke syndrome, hysteria, epilepsy, etc. and have achieved immediate results.

  16. Male Osteoporosis

    Directory of Open Access Journals (Sweden)

    Meltem Esenyel

    2004-03-01

    Full Text Available Osteoporosis in men is now recognized as an increasingly important public health issue. About 30 % of hip fractures and 20 % of vertebral fractures occur in men. In the present study, we examined 19 men who did not have major risk factors that might affect bone mass. Parathormone(PTH, osteocalcin (marker of bone formation, OC and deoxypyridinoline (marker of bone resorption, DPD were measured. The bone mineral density (BMD measurements in 16 men were performed by dual-energy X-ray absorbtiometry (DXA from lumbar spine (L2-4, and left hip. Bone density at each site was categorized as osteoporosis or osteopenia according to World Health Organization (WHO criteria. In 19 patients with a mean age of 69 years, PTH levels were in the normal range except one patient. OC levels were elevated in %42.1 and DPD levels were elevated in 74 % of patients. L2-4 T score was osteoporotic (25% in 4 patients and osteopenic (25% in 4 patients. Femur Ward’s T score was osteoporotic (37.5% in 7 patients and osteopenic (37.5% in 7 patients. Osteoporosis is a significant problem in older men. Increased awareness for the risk factors of male osteoporosis is an important issue. Early diagnosis and treatment would help to reduce morbidity and mortality resulting from osteoporotic fractures.

  17. Chapter Twelve

    African Journals Online (AJOL)

    User

    dissemination in Nigeria· Some local jingles from Radio Nigeria Purity F.M. .... Indigenous Language in Advertisement: Problems and Prospects – Thecla ... the rural newspapers from performing their role of rural development· The ..... Sharma Raman, M· and, S (2004), Technical Communication Principle and Practice· India:.

  18. Parenting Interventions for Male Young Offenders: A Review of the Evidence on What Works

    Science.gov (United States)

    Buston, K.; Parkes, A.; Thomson, H.; Wight, D.; Fenton, C.

    2012-01-01

    Approximately one in four incarcerated male young offenders in the UK is an actual or expectant father. This paper reviews evidence on the effectiveness of parenting interventions for male young offenders. We conducted systematic searches across 20 databases and consulted experts. Twelve relevant evaluations were identified: 10 from the UK, of…

  19. [Male contraception].

    Science.gov (United States)

    Demoulin, A

    1984-04-01

    Among the reasons why male hormonal contraception has lagged behind female methods are the necessity of preserving virility, the fact that spermatogenesis is a continuous process, the need to control secondary effects and toxicity, and the requirement that modes of administration be acceptable to both partners. Among currently available reversible mehtods, withdrawal is undoubtedly the most ancient. It is still widespread but cannot be recommended because of its limited effectiveness. The condom is used by about 10% of couples worldwide as a principal or temporary method, but its inter-ference with sensation has limited its acceptance. Condoms are nevertheless highly effective when used with a spermicide. Various androgens are currently under investigation. High doses of testosterone can induce azoospermia without affecting libido but their side effects may be serious. The use of combinations of steroids permits doses to be reduced and offers promise for the future. The combination of oral medroxyprogesterone acetate and percutaneous testosterone is one of the better approaches; the combination is effective and nontoxic but has the disadvantage of percutaneous administration. Gossypol, a pigment extracted from the cotton plant, has been used as a contraceptive in China with a reported efficacy of 99.89%, recovery of fertility within 3 months, and no effect on future fertility. However, its toxicity appears to be significant in the animal and its reversibility is uncertain. A search is on for analogs which would preserve the contraceptive effects while eliminating toxic effects. Several gonadotropin releasing hormone (GnRH) analogs under investigation for their interference with spermatogenesis have given promising results. Several chemicals tested for contraceptive effects have had unacceptably high toxicity. Chinese investigators have reported good results with various physical methods of interfering with sperm production, but their reversibility and innocuity

  20. Isolation and characterization of twelve microsatellite loci for the Japanese Devilray (Mobula japanica)

    NARCIS (Netherlands)

    Poortvliet, Marloes; Galvan-Magana, Felipe; Bernardi, Giacomo; Croll, Donald A.; Olsen, Jeanine L.

    2011-01-01

    Twelve polymorphic microsatellites loci were characterized for Mobula japanica (Japanese Devilray) using an enrichment protocol. All but two loci were in Hardy-Weinberg equilibrium with no evidence of linkage disequilibrium or null-alleles for a sample of 40 individuals from two populations. The num

  1. 17 CFR 210.3-06 - Financial statements covering a period of nine to twelve months.

    Science.gov (United States)

    2010-04-01

    ... ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935, INVESTMENT COMPANY ACT OF 1940, INVESTMENT ADVISERS ACT OF 1940, AND ENERGY POLICY AND CONSERVATION ACT OF 1975... to twelve months. Except with respect to registered investment companies, the filing of...

  2. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  3. Premarital sex in the last twelve months and its predictors among ...

    African Journals Online (AJOL)

    Premarital sex in the last twelve months and its predictors among students of ... Statistical significance was determined through a 95% confidence level. ... having comprehensive knowledge of HIV [AOR(95% CI)=1.5(1.01-2.10)], alcohol use ...

  4. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  5. A novel double quad-inverter configuration for multilevel twelve-phase open-winding converter

    DEFF Research Database (Denmark)

    Padmanaban, Sanjeevi Kumar; Blaabjerg, Frede; Wheeler, Patrick William

    2016-01-01

    This paper describes a novel proposal of double quad-inverter configuration for multilevel twelve-phase open-winding ac converter. Modular power units are developed from reconfigured eight classical three-phase voltage source inverters (VSIs). Each VSI has one additional bi-directional switching ...

  6. Effects of dietary crude protein on the growth performance, carcass characteristics and serum biochemical indexes of Lueyang black-boned chickens from seven to twelve weeks of age

    Directory of Open Access Journals (Sweden)

    SK Liu

    2015-03-01

    Full Text Available This study was undertaken to assess dietary crude protein (CP concentration for optimum growth performance and carcass characteristics of Lueyang black-boned chicken. In total, six hundred 42-day-old Lueyang black-boned chicks were randomly assigned to five treatments, each with six replicate pens with ten males and ten females. The birds fed experimental diets with different levels of protein concentration of 120, 140, 160, 180 and 200 g kg-1 from seven to twelve weeks of age respectively. On day of 84, weight gain, feed intake, and feed:gain ratio were measured, and two chickens (one male and one female close to the average weight of all birds in each treatment were selected from each pen and sacrificed to evaluate carcass traits and selected serum biochemical indexes. Dietary CP concentration did not have any significant influence on feed intake (p>0.05. The birds fed the diet with 180 or 160 g kg-1 CP concentration exhibited greater (p<0.05 growth rate, better feed conversion ratio, relative breast weight and albumin concentration in serum than that of those fed other dietary CP concentrations. According to the results of regression analysis, the CP requirements of Lueyang black-boned chicken from seven to twelve weeks of age for optimal weight gain and feed:gain ratio were 174 and 170 g kg-1, respectively.

  7. The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Toothpaste for controlling breath odor twelve hours after toothbrushing: a single-use clinical study.

    Science.gov (United States)

    Sharma, Naresh C; Galustians, H Jack; Qaqish, Jimmy; Galustians, Ana; Petrone, Margaret E; Rustogi, Kedar N; Zhang, Yun Po; DeVizio, William; Volpe, Anthony R

    2002-01-01

    The objective of this double-blind clinical study, conducted in harmony with American Dental Association guidelines, was to compare a new dentifrice formulation variant of Colgate Total Toothpaste containing a special grade of silica (Colgate Total Plus Whitening Toothpaste) to the commercially available, ADA-Accepted and clinically proven Colgate Total Toothpaste for controlling breath odor twelve hours after brushing the teeth. Breath odor was evaluated by a panel of three examiners using a nine-point hedonic scale. Following a baseline evaluation of breath odor, prospective study subjects who scored above the threshold value for unpleasant breath odor were stratified by score and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush, and brushed their teeth thoroughly in their regular and customary manner with their assigned dentifrice. Subjects refrained from dental hygiene, breath mints or mounthrinses for the next twelve hours, after which they were again evaluated for breath odor. Eighty-three (83) adult male and female subjects from the Mississauga, Ontario, Canada area participated in the study. At twelve hours after brushing their teeth, subjects in both dentifrice treatment groups presented mean breath odor scores which were statistically significantly lower than the mean scores observed at baseline. Importantly, there was no statistical difference between the two dentifrices of the mean twelve-hour breath odor scores. The mean twelve-hour breath scores for the Colgate Total Plus Whitening Toothpaste group and the Colgate Total Toothpaste group were 4.89 and 4.67, respectively, which are within the range of values corresponding to pleasant breath odor. Thus, the results of this double-blind clinical study, conducted according to a protocol which had been approved by the Council on Scientific Affairs of the American Dental Association, support the conclusion that Colgate Total Plus Whitening Toothpaste and Colgate

  8. Anatomical studies on twelve clones of Camellia species with reference to their taxonomic significance

    Directory of Open Access Journals (Sweden)

    Rajanna L

    2010-10-01

    Full Text Available Anatomical studies of leaf and stem of twelve clones of Camellia were investigated. Cross sections of the stem of all the clones exhibited a typical pattern of arrangement of tissues characteristics of woody plants. Two types of idioblastic sclereids were found in the medullary parenchyma of the taxa studied. While astrosclereids werepresent in 10 of the twelve clones, the vesciculose sclereids were found only in the four clones belonging to C. sinensis. Leaves of the clones show variations in the number of palisade layers. Astro sclereids, brachy sclereids, and dendritic forms were observed in the leaves, their distribution varying in the different clones. A few other micromorphological features are also recorded. Our study forms a basis for answering uncertainties in taxonomic revision in the genus Camellia.

  9. Descriptions of twelve new species of ochyroceratids (Araneae, Ochyroceratidae) from mainland Ecuador.

    Science.gov (United States)

    Dupérré, Nadine

    2015-05-12

    Twelve new species in three different genera from the spider family Ochyroceratidae are described from mainland Ecuador: Speocera bioforestae sp. n., Speocera violacea sp. n., Speocera musgo sp. n., Ochyrocera rinocerotos sp. n., Ochyrocera callaina sp. n., Ochyrocera italoi sp. n., Ochyrocera minotaure sp. n., Ochyrocera losrios sp. n., Ochyrocera zabaleta sp. n., Ochyrocera otonga sp. n., Ochyrocera cashcatotoras sp. n. and Psiloochyrocera tortilis sp. n. Speocera machadoi Gertsch 1977 is transferred to Ochyrocera.

  10. A Hidden Twelve-Dimensional SuperPoincare Symmetry In Eleven Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2003-12-13

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional superPoincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven dimensional superparticle, taken off-shell, we discover a hidden twelve dimensional superPoincare symmetry that governs the theory.

  11. Hidden twelve-dimensional super Poincaré symmetry in eleven dimensions

    CERN Document Server

    Bars, Itzhak; Pasqua, A; Zumino, B; Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2004-01-01

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional superPoincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven dimensional superparticle, taken off-shell, we discover a hidden twelve dimensional superPoincare symmetry that governs the theory.

  12. Male pattern baldness

    Science.gov (United States)

    Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

  13. Target Value Evaluation of the Mechanized Infantry Division Joint Fires Attack Based on Optimization Theory%基于最优化理论的机步师联合火力打击目标价值评估

    Institute of Scientific and Technical Information of China (English)

    邹进; 许劲松

    2012-01-01

    According to the characteristics of the mechanized infantry division joint fires attack in city offensive combat under informa tion condition, by the means of optimization theory decision-making, and an example is used for demonstrating the effectiveness and feasibili ty of the model, the paper analyzes and prioritizes battlefield target value for artillery commanders.%根据信息化条件下机步师城市进攻战斗联合火力打击特点,以最优化理论为基础,对战场联合火力打击目标价值进行了分析和排序,并通过实例对该模型的有效性和实用性进行了验证,为指挥员的决策行为提供了理论依据。

  14. Definition of a Twelve-Point Polygonal SAA Boundaryfor the GLAST Mission

    Energy Technology Data Exchange (ETDEWEB)

    Djomehri, Sabra I.; /UC, Santa Cruz /SLAC

    2007-08-29

    The Gamma-Ray Large Area Space Telescope (GLAST), set to launch in early 2008, detects gamma rays within a huge energy range of 100 MeV - 300 GeV. Background cosmic radiation interferes with such detection resulting in confusion over distinguishing cosmic from gamma rays encountered. This quandary is resolved by encasing GLAST's Large Area Telescope (LAT) with an Anti-Coincidence Detector (ACD), a device which identifies and vetoes charged particles. The ACD accomplishes this through plastic scintillator tiles; when cosmic rays strike, photons produced induce currents in Photomultiplier Tubes (PMTs) attached to these tiles. However, as GLAST orbits Earth at altitudes {approx}550km and latitudes between -26 degree and 26 degree, it will confront the South Atlantic Anomaly (SAA), a region of high particle flux caused by trapped radiation in the geomagnetic field. Since the SAA flux would degrade the sensitivity of the ACD's PMTs over time, a determined boundary enclosing this region need be attained, signaling when to lower the voltage on the PMTs as a protective measure. The operational constraints on such a boundary require a convex SAA polygon with twelve edges, whose area is minimal ensuring GLAST has maximum observation time. The AP8 and PSB97 models describing the behavior of trapped radiation were used in analyzing the SAA and defining a convex SAA boundary of twelve sides. The smallest possible boundary was found to cover 14.58% of GLAST's observation time. Further analysis of defining a boundary safety margin to account for inaccuracies in the models reveals if the total SAA hull area is increased by {approx}20%, the loss of total observational area is < 5%. These twelve coordinates defining the SAA flux region are ready for implementation by the GLAST satellite.

  15. Performance of Basic Infantry Tasks

    Science.gov (United States)

    1989-07-01

    tripwire until the locking safety pin was pulled into the wide portion of the safety pin hole. 14. Moved to the mine, and emplaced a third - stake slightly...Returned to the firing device and with- the attached string pulled out the locking safety pin . RECOVER SAY: Now recover the mine. Inspected the mine and...attached trip- NT SCORED wires to determine if they had been altered, damaged, or boobytrapped. 20. Inserted the locking safety pin in safety pin hole

  16. Load carriage by infantry soldiers

    Directory of Open Access Journals (Sweden)

    N. C. Majumdar

    1958-07-01

    Full Text Available At constant speed of marching, oxygen consumption has been found to increase linearly with the amount of load carried, indicating that there is no optimum load. However, an optimum speed of marching has been found, depending on the terrain condition. A different line of approach, involving a study of the relationship between stride-length, frequency of stepping and speed in normal walking and the effect of muscular fatigue on this relationship has also yielded similar results. Desirability of further studies on the effect of load on optimum speed of marching, effective reduction of weight of equipment and optimum distribution of load on the body has been stressed.

  17. The correlation between reading and mathematics ability at age twelve has a substantial genetic component.

    Science.gov (United States)

    Davis, Oliver S P; Band, Gavin; Pirinen, Matti; Haworth, Claire M A; Meaburn, Emma L; Kovas, Yulia; Harlaar, Nicole; Docherty, Sophia J; Hanscombe, Ken B; Trzaskowski, Maciej; Curtis, Charles J C; Strange, Amy; Freeman, Colin; Bellenguez, Céline; Su, Zhan; Pearson, Richard; Vukcevic, Damjan; Langford, Cordelia; Deloukas, Panos; Hunt, Sarah; Gray, Emma; Dronov, Serge; Potter, Simon C; Tashakkori-Ghanbaria, Avazeh; Edkins, Sarah; Bumpstead, Suzannah J; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz A Z; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Barroso, Ines; Peltonen, Leena; Dale, Philip S; Petrill, Stephen A; Schalkwyk, Leonard S; Craig, Ian W; Lewis, Cathryn M; Price, Thomas S; Donnelly, Peter; Plomin, Robert; Spencer, Chris C A

    2014-07-08

    Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.

  18. New Eyes on the Universe Twelve Cosmic Mysteries and the Tools We Need to Solve Them

    CERN Document Server

    Webb, Stephen

    2012-01-01

    "New Eyes on the Universe -- Twelve Cosmic Mysteries and the Tools We Need to Solve Them" gives an up-to-date broad overview of some of the key issues in modern astronomy and cosmology. It describes the vast amount of observational data that the new generation of observatories and telescopes are currently producing, and how that data might solve some of the outstanding puzzles inherent in our emerging world view. Included are questions such as: What is causing the Universe to blow itself apart? What could be powering the luminous gamma-ray bursters? Where is all the matter in the Uni

  19. DETECTION OF CHROMOSOME ABERRATIONS IN TWELVE PRIMARY GASTRIC CANCERS BY DIRECT CHROMOSOME ANALYSIS AND FISH

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Direct chromosome analysis and FISH were performed on twelve primary gastric carcinomas. Two of them had simple chromosome changes: 48,XX, +8, +20, and 49, XY, +2, +8, +9, and the others had complicated chromosome changes, which includes much more numerical and structural chromosome aberrations. Frequent structural changes in the complicated types involved chromosome 7, 3, 1, 5 and 12 etc. The del 7q was noted in eight cases. The del (3p) and del (1p) were noted in six and five cases, respectively. The results provide some important clues for isolation of the genes related to gastric cancer.

  20. Developing a learning culture: twelve tips for individuals, teams and organizations.

    Science.gov (United States)

    Stinson, Lynn; Pearson, David; Lucas, Beverley

    2006-06-01

    A culture of learning in providing health services and education for health professionals is a constant challenge for individuals, team and organizations. The importance of such a culture was highlighted by the findings of the Bristol Royal Infirmary Inquiry (2001). This was discussed in the context of the literature on the Learning Organization (Senge, 1990) at the 2004 Association of Medical Education in Europe (AMEE) conference, and reviewed a year later at the 2005 AMEE conference. This paper outlines twelve tips for educational and health service organizations in facilitating a culture of learning for their members and also offers specific advice to individual students and professionals.

  1. Work environment perceptions following relocation to open-plan offices: A twelve-month longitudinal study.

    Science.gov (United States)

    Bergström, Jessica; Miller, Michael; Horneij, Eva

    2015-01-01

    A workplace's design can have various positive or negative effects on the employees and since the 1970s the advantages and disadvantages of open-plan offices have been discussed. The aim of this study was to investigate perceived health, work environment and self-estimated productivity one month before and at three, six and twelve months after relocation from individual offices to an open-plan office environment. Employees from three departments within the same company group and who worked with relatively similar tasks and who were planned to be relocated from private offices to open-plan offices were invited to participate. Questionnaires comprising items from The Salutogenic Health Indicator Scale, The Work Experience Measurement Scale, the questionnaire by Brennan et al. about perceived performance and one question from the Work Ability Index were sent to participants one month before relocation (baseline) to open-plan offices and then at three, six and twelve months after relocation. At baseline, 82 questionnaires were sent out. The response rate was 85%. At the follow-ups 77-79 questionnaires were sent out and the response-rate was 70%-81%. At follow-ups, perceived health, job satisfaction and performance had generally deteriorated. The results of the study indicate that employees' perception of health, work environment and performance decreased during a 12 month period following relocation from individual offices to open-plan offices.

  2. Approximate analytic method for high-apogee twelve-hour orbits of artificial Earth's satellites

    Science.gov (United States)

    Vashkovyaka, M. A.; Zaslavskii, G. S.

    2016-09-01

    We propose an approach to the study of the evolution of high-apogee twelve-hour orbits of artificial Earth's satellites. We describe parameters of the motion model used for the artificial Earth's satellite such that the principal gravitational perturbations of the Moon and Sun, nonsphericity of the Earth, and perturbations from the light pressure force are approximately taken into account. To solve the system of averaged equations describing the evolution of the orbit parameters of an artificial satellite, we use both numeric and analytic methods. To select initial parameters of the twelve-hour orbit, we assume that the path of the satellite along the surface of the Earth is stable. Results obtained by the analytic method and by the numerical integration of the evolving system are compared. For intervals of several years, we obtain estimates of oscillation periods and amplitudes for orbital elements. To verify the results and estimate the precision of the method, we use the numerical integration of rigorous (not averaged) equations of motion of the artificial satellite: they take into account forces acting on the satellite substantially more completely and precisely. The described method can be applied not only to the investigation of orbit evolutions of artificial satellites of the Earth; it can be applied to the investigation of the orbit evolution for other planets of the Solar system provided that the corresponding research problem will arise in the future and the considered special class of resonance orbits of satellites will be used for that purpose.

  3. Global surface temperature change analysis based on MODIS data in recent twelve years

    Science.gov (United States)

    Mao, K. B.; Ma, Y.; Tan, X. L.; Shen, X. Y.; Liu, G.; Li, Z. L.; Chen, J. M.; Xia, L.

    2017-01-01

    Global surface temperature change is one of the most important aspects in global climate change research. In this study, in order to overcome shortcomings of traditional observation methods in meteorology, a new method is proposed to calculate global mean surface temperature based on remote sensing data. We found that (1) the global mean surface temperature was close to 14.35 °C from 2001 to 2012, and the warmest and coldest surface temperatures of the global in the recent twelve years occurred in 2005 and 2008, respectively; (2) the warmest and coldest surface temperatures on the global land surface occurred in 2005 and 2001, respectively, and on the global ocean surface in 2010 and 2008, respectively; and (3) in recent twelve years, although most regions (especially the Southern Hemisphere) are warming, global warming is yet controversial because it is cooling in the central and eastern regions of Pacific Ocean, northern regions of the Atlantic Ocean, northern regions of China, Mongolia, southern regions of Russia, western regions of Canada and America, the eastern and northern regions of Australia, and the southern tip of Africa. The analysis of daily and seasonal temperature change indicates that the temperature change is mainly caused by the variation of orbit of celestial body. A big data model based on orbit position and gravitational-magmatic change of celestial body with the solar or the galactic system should be built and taken into account for climate and ecosystems change at a large spatial-temporal scale.

  4. Investigation & analysis on the armored infantry with nonspecific low back pain induced by resonance%谐振致装甲步兵肌源性下腰痛的调查与分析

    Institute of Scientific and Technical Information of China (English)

    赵亮; 黄昌林

    2015-01-01

    Objective To analyze the incidence of myogenic low back pain in the armored infantry, investigate the impact of resonance,as well as the effectiveness of back muscle strength training. Methods With the self-designed questionnaire and the diagnosis standard of myogenic low back pain,the findings of 402 cases of armored infantry undergoing resonance was investigated. The degree of the pain and incidence were compared in armored infantry with different specialty and enlist time. By performing back muscle strength training,the symptomatic relief was observed. Results The prevalence of low back pain in this population was 12.93%;20.36% in occupant,7.66% in manning occurrence,so their the incidence had statistically difference (P<0.001);Also 8.21% with Ⅰ degree of pain,3.98% with Ⅱ degree,0.75% with Ⅲ degree,so the incidence of the three degrees had statistical difference (P<0.05);Performing back muscle strength training,1 case was of low back pain in group A (i.e health control non-intervention group);Group B (i.e health control + intervention group) had no low back pain patients,19 cases of group C (i.e case-group without intervention) had symptomatic relief,24 cases of Group D (i.e case-group with intervention) had symptomatic relief. Conclusion Armored infantry is a high-risk population of myogenic low back pain;Resonance vibration is an important risk factor for myogenic low back pain in the armored infantry;Most of them with Ⅰ or Ⅱ degree of pain; myogenic low back pain can be effectively lightened by back muscle strength training.%目的 对装甲步兵肌源性下腰痛的发生率进行分析,了解谐振对肌源性下腰痛的影响,以及腰背肌相对肌力训练对改善肌源性下腰痛的效果. 方法 采用自制调查表及拟定的肌源性下腰痛诊断标准, 对某部402名装甲步兵肌源性下腰痛发生情况进行调查, 比较不同专业和军龄战士肌源性下腰痛的发生率及疼痛程度;对肌源性下腰痛患者

  5. Comparative assay of fluorescent antibody test results among twelve European National Reference Laboratories using various anti-rabies conjugates

    DEFF Research Database (Denmark)

    Robardet, E.; Andrieu, S.; Rasmussen, Thomas Bruun

    2013-01-01

    Twelve National Reference Laboratories (NRLs) for rabies have undertaken a comparative assay to assess the comparison of fluorescent antibody test (FAT) results using five coded commercial anti-rabies conjugates (Biorad, Bioveta, Fujirebio, Millipore, and SIFIN conjugates). Homogenized positive...

  6. [Male urinary incontinence

    NARCIS (Netherlands)

    Boer, TA de; Heesakkers, J.P.F.A.

    2008-01-01

    *Urinary incontinence in males is gaining increasingly more attention. *Male urinary incontinence can be classified as storage incontinence due to overactive bladder syndrome or stress incontinence due to urethral sphincter dysfunction. *Most patients benefit from the currently available treatment o

  7. Male pattern baldness (image)

    Science.gov (United States)

    Male pattern baldness is a sex-linked characteristic that is passed from mother to child. A man can more accurately predict his chances of developing male pattern baldness by observing his mother's father than by looking ...

  8. Exploring Content Schemata Influence on L2 Reading: The Hunted Fox and Twelve and Not Stupid

    Directory of Open Access Journals (Sweden)

    Amizura Hanadi Mohd Radzi

    2014-10-01

    Full Text Available This paper will discuss the aspects of content schemata in second language reading among diploma level students who were taking a reading course in Universiti Teknologi MARA Perlis. In this qualitative case study, the researcher had selected two short stories that are categorized as content-familiar texts, i.e. The Hunted Fox and Twelve and Not Stupid. Six participants were asked to write a 150-word entry response on the short story and a grading criteria was used to assess the participants’ level of comprehension. An in-depth interview was also conducted on each participant. The entry responses and the interview patterns were analyzed to determine whether content schemata had contributed to the learners’ understanding of the text. This study discovered that content schemata had contributed to the learners’ understanding of the text because the learners’ comprehension was facilitated by their background knowledge on the content-familiar texts.

  9. Development and characterization of twelve microsatellite markers for Porphyra linearis Greville.

    Science.gov (United States)

    Varela-Álvarez, Elena; Paulino, Cristina; Serrão, Ester A

    2017-02-01

    The genus Porphyra (and its sister genus Pyropia) contains important red algal species that are cultivated and/or harvested for human consumption, sustaining a billion-dollar aquaculture industry. A vast amount of research has been focused on species of this genus, including studies on genetics and genomics among other areas. Twelve novel microsatellite markers were developed here for Porphyra linearis. Markers were characterized using 32 individuals collected from four natural populations of P. linearis with total heterozygosity varying from 0.098 to 0.916. The number of alleles per locus ranged from 2 to 18. All markers showed cross amplification with Porphyra umbilicalis and/or Porphyra dioica. These polymorphic microsatellite markers are useful for investigating population genetic diversity and differentiation in P. linearis and may become useful for other genetic research on the reproductive biology of this important species.

  10. Proteomic characterization of human milk whey proteins during a twelve-month lactation period.

    Science.gov (United States)

    Liao, Yalin; Alvarado, Rudy; Phinney, Brett; Lönnerdal, Bo

    2011-04-01

    Human milk is a rich source of bioactive proteins that support the early growth and development of the newborn. Although the major components of the protein fraction in human milk have been studied, the expression and relative abundance of minor components have received limited attention. We examined the expression of low-abundance proteins in the whey fraction of human milk and their dynamic changes over a twelve-month lactation period. The low-abundance proteins were enriched by ProteoMiner beads, and protein identification was performed by liquid chromatography tandem mass spectrometry. One hundred and fifteen proteins were identified, thirty-eight of which have not been previously reported in human colostrum or milk. We also for the first time described differences in protein patterns among the low-abundance proteins during lactation. These results enhance our knowledge about the complexity of the human milk proteome, which constitutes part of the advantages to the breast-fed infant.

  11. Fate of the conformal fixed point with twelve massless fermions and SU(3) gauge group

    CERN Document Server

    Fodor, Zoltan; Kuti, Julius; Mondal, Santanu; Nogradi, Daniel; Wong, Chik Him

    2016-01-01

    We report new results on the conformal properties of an important strongly coupled gauge theory, a building block of composite Higgs models beyond the Standard Model. With twelve massless fermions in the fundamental representation of the SU(3) color gauge group, an infrared fixed point of the $\\beta$-function was recently reported in the theory (Cheng:2014jba) with uncertainty in the location of the critical gauge coupling inside the narrow $[ 6.0

  12. Twelve Years of Education and Public Outreach with the Fermi Gamma-ray Space Telescope

    CERN Document Server

    Cominsky, Lynn; Simonnet, Aurore; Education, the Fermi

    2013-01-01

    During the past twelve years, NASA's Fermi Gamma-ray Space Telescope has supported a wide range of Education and Public Outreach (E/PO) activities, targeting K-14 students and the general public. The purpose of the Fermi E/PO program is to increase student and public understanding of the science of the high-energy Universe, through inspiring, engaging and educational activities linked to the mission's science objectives. The E/PO program has additional more general goals, including increasing the diversity of students in the Science, Technology, Engineering and Mathematics (STEM) pipeline, and increasing public awareness and understanding of Fermi science and technology. Fermi's multi-faceted E/PO program includes elements in each major outcome category: Higher Education; Elementary and Secondary Education; Informal Education and Public Outreach.

  13. Twelve tips for developing and delivering a massive open online course in medical education.

    Science.gov (United States)

    Pickering, James D; Henningsohn, Lars; DeRuiter, Marco C; de Jong, Peter G M; Reinders, Marlies E J

    2017-07-01

    Massive open online courses (MOOCs) are a novel mode of online learning. They are typically based on higher education courses and can attract a high number of learners, often in the thousands. They are distinct from on-campus education and deliver the learning objectives through a series of short videos, recommended readings and discussion fora, alongside automated assessments. Within medical education the role of MOOCs remains unclear, with recent proposals including continuing professional development, interprofessional education or integration into campus-based blended learning curricula. In this twelve tips article, we aim to provide a framework for readers to use when developing, delivering and evaluating a MOOC within medical education based on the literature and our own experience. Practical advice is provided on how to design the appropriate curriculum, engage with learners on the platform, select suitable assessments, and comprehensively evaluate the impact of your course.

  14. Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.

    Science.gov (United States)

    Yang, Ya-Nan; Huang, Xiao-Ying; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Pei-Cheng

    2014-09-17

    Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-O-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly known as Arctii Fructus. Their structures were elucidated using spectroscopy (1D and 2D NMR, MS, IR, ORD, and UV) and on the basis of chemical evidence. The absolute configurations of compounds 1-12 were confirmed using rotating frame nuclear overhauser effect spectroscopy (ROESY), the circular dichroic (CD) exciton chirality method, and Rh2(OCOCF3)4-induced CD spectrum analysis. All of the isolated compounds were tested for hepatoprotective effects against D-galactosamine-induced cytotoxicity in HL-7702 hepatic cells. Compounds 1, 2, 7-12, and 17 showed significantly stronger hepatoprotective activity than the positive control bicyclol at a concentration of 1 × 10(-5) M.

  15. Twelve Tips for teaching medical professionalism at all levels of medical education.

    Science.gov (United States)

    Al-Eraky, Mohamed Mostafa

    2015-01-01

    Review of studies published in medical education journals over the last decade reveals that teaching medical professionalism is essential, yet challenging. According to a recent Best Evidence in Medical Education (BEME) guide, there is no consensus on a theoretical or practical model to integrate the teaching of professionalism into medical education. The aim of this article is to outline a practical manual for teaching professionalism at all levels of medical education. Drawing from research literature and author's experience, Twelve Tips are listed and organised in four clusters with relevance to (1) the context, (2) the teachers, (3) the curriculum, and (4) the networking. With a better understanding of the guiding educational principles for teaching medical professionalism, medical educators will be able to teach one of the most challenging constructs in medical education.

  16. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

    Directory of Open Access Journals (Sweden)

    Hermans Peter WM

    2011-01-01

    Full Text Available Abstract Background M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM and exacerbations of chronic obstructive pulmonary disease (COPD. With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. Results The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH, which posits that the species genome possesses a far greater number of genes than any single isolate. Multiple and pair-wise whole genome alignments highlight limited chromosomal re-arrangement. Conclusions M. catarrhalis gene content and chromosomal organization data, although supportive of the DGH, show modest overall genic diversity. These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens.

  17. Imaging male breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, S., E-mail: sdoyle2@nhs.net [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom); Steel, J.; Porter, G. [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom)

    2011-11-15

    Male breast cancer is rare, with some pathological and radiological differences from female breast cancer. There is less familiarity with the imaging appearances of male breast cancer, due to its rarity and the more variable use of preoperative imaging. This review will illustrate the commonest imaging appearances of male breast cancer, with emphasis on differences from female breast cancer and potential pitfalls in diagnosis, based on a 10 year experience in our institution.

  18. 46,XX Male Syndrome

    Directory of Open Access Journals (Sweden)

    Bekir Uçan

    2013-06-01

    Full Text Available 46, XX male syndrome – testicular disorder of sexual differentiation (DSD is a rare condition characterized by a spectrum of clinical presentations, ranging from ambiguous to normal male genitalia. These cases are diagnosed more easily in childhood. In adults, the diagnosis can be difficult due to the current normal gender development. Here, we report hormonal, molecular and cytogenetic results in an adult male patient with primary hypogonadism who was diagnosed with 46, XX male syndrome in our clinic. Turk Jem 2013; 17: 46-8

  19. Twelve-year cyclic surging episode at Donjek Glacier in Yukon, Canada

    Science.gov (United States)

    Furuya, M.; Abe, T.; Sakakibara, D.

    2015-12-01

    Surge-type glaciers exhibit several-fold to orders-of-magnitude speed-up during the short active phase, resulting in km-scale terminus advance. Although there are many surge-type glaciers near the border of Alaska and the Yukon, the generation mechanisms remain uncertain because of limited and few continuous observations. To better understand the surge dynamics and predict the next event, it is essential to examine the entire surge cycles. Here we use Landsat optical imageries to reveal the long-term evolutions, and report three surging episodes at Donjek Glacier in Yukon, Canada. Using the Landsat images, we found three surging events in 1989, 2001, and 2013. In the 2001 event, the surface speed significantly increased by up to 4.5 m/d; during the quiescent phases it was ~0.5 m/d at the terminus. While the duration of active phase is about 4~5 and 2~3 year in the 2001 and 2013 events, the period in the 1989 event is unclear because of the lack of high temporal resolution data. Remarkably, the surging area is limited to the ~20-km section from the terminus instead of the entire glacier. Moreover, we examined the terminus area changes from 1975 to 2014. Although the area has been secularly decreasing probably due to the tread of global warming, it has also revealed four significant fluctuations during the nearly forty years. Comparing the speed and the area changes, the three speed-up events correspond to the terminus area fluctuations with a few time lags. It turns out that the surge event has been quite regularly repeating every twelve years. Although the behavior is rather similar to that in Svalbard glaciers in terms of maximum speed and unclear initiation season, the recurrence interval is much shorter than other nearby surges. Considering that the surge events seem to have initiated around significantly narrower area than upstream, the strong valley constriction may control the regularity as well as the twelve-year recurrence time.

  20. The epidemiological investigation and analysis of bone-derived low back pain in armored infantry%装甲步兵骨关节源性下腰痛调查与分析

    Institute of Scientific and Technical Information of China (English)

    王宪卫; 黄昌林

    2015-01-01

    目的 抽样调查某部装甲步兵职业性骨关节源性下腰痛的发生原因及分布情况,探讨其流行特征及预防措施.方法 以问卷结合体格检查的方式,依照《军事训练伤诊断标准及防治原则》(WSB38-2001)中所规定军事训练所致下腰痛的诊断标准,对某部参训装甲步兵进行骨关节源性下腰痛流行病学调查,采集数据资料,并进行相关分析. 结果 被筛选调查的402名参训装甲步兵罹患下腰痛113例,发生率28.11%. 其中骨关节源性下腰痛24例,发生率为5.97%,占下腰痛人员比例21.24%.≥2年军龄骨关节源型下腰痛发病率为10.93%,明显高于≤1年军龄组的5.19%和1~2年军龄组的4.76%(P<0.05).在骨关节源性下腰痛24名战士中,乘员17名,所占比例高达70.83%,载员7名,占29.17%.装甲乘员比例明显高于装甲载员(P<0.05).24例装甲步兵组骨关节源性下腰痛伤员中,Ⅰ度疼痛患者发生率较高(3.98%),明显高于Ⅱ度疼痛伤员(1.49%)(P<0.05),Ⅲ度以上的患者发生率极低,仅为0.50%,三组发病率比较有统计学意义(P<0.05).此外,腰背肌相对肌力素质锻炼的方法进行干预治疗,结果没有新增骨关节源性下腰痛伤员,且有7名骨关节源性下腰痛伤员症状减轻. 结论 通过调查发现,装甲步兵下腰痛发病率较高,骨关节源性下腰痛所占比例不可忽视,主要集中在≥2年军龄,其中装甲乘员明显高于装甲载员,腰背肌相对肌力素质锻炼对于骨关节源性下腰痛的预防和治疗均具有明显的效果. 因此,在平常的军事训练及作业中,应该加强腰背肌锻炼及健康宣教工作,减少骨关节源性下腰痛的发生.%Objective To investigate the cause and the distribution of bone-derived low back pain of armored infantry and to discuss the epidemiological features and preventions. Methods Combined with the questionnaire and physical examination,authors conducted the epidemiological investigation and the

  1. Male Adolescent Contraceptive Utilization.

    Science.gov (United States)

    Finkel, Madelon Lubin; Finkel, David J.

    1978-01-01

    The contraceptive utilization of a sample of sexually active, urban, high school males (Black, Hispanic, and White) was examined by anonymous questionnaire. Contraceptive use was haphazard, but White males tended to be more effective contraceptors than the other two groups. Reasons for nonuse were also studied. (Author/SJL)

  2. Margalef revisited: A new phytoplankton mandala incorporating twelve dimensions, including nutritional physiology.

    Science.gov (United States)

    Glibert, Patricia M

    2016-05-01

    Building on the classic depiction of the progression from a diatom to a dinoflagellate bloom as a function of nutrients and turbulence, known as the "Margalef mandala", a new conceptual model or mandala is presented here. The new mandala maps twelve response or effects traits, or environmental characteristics, related to different phytoplankton functional types: (1) relative preference for chemically reduced vs chemically oxidized forms of nitrogen; (2) relative availability of inorganic nitrogen and phosphorus; (3) adaptation to high vs low light and the tendency to be autotrophic vs mixotrophic; (4) cell motility; (5) environmental turbulence; (6) pigmentation quality; (7) temperature; (8) cell size; (9) relative growth rate; (10) relative production of bioactive compounds such as toxins or reactive oxygen species (ROS); (11) r vs K strategy; and (12) fate of the production in terms of grazing. The new mandala serves to highlight the differences and trade-offs between traits and/or environmental conditions, and illustrates some traits tend to track each other, a concept that may be helpful in trait-based modeling approaches and in understanding environmental factors associated with harmful algal blooms. It is hoped that this new mandala captures some of our recent insight into phytoplankton physiology and functional traits, and has contemporary relevance in light of anthropogenic changes in nutrient form and ratio. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Margalef revisited: A new phytoplankton mandala incorporating twelve dimensions, including nutrient ratios and forms

    Science.gov (United States)

    Glibert, P. M.

    2016-02-01

    Building on the classic depiction of the progression from a diatom to a dinoflagellate bloom as a function of nutrients and turbulence, known as the "Margalef mandala", a new conceptual model or mandala is presented here. The new mandala maps twelve traits or environmental characteristics related to different phytoplankton functional types: (1) relative preference for chemically reduced vs chemically oxidized forms of nitrogen; (2) relative availability of inorganic nitrogen and phosphorus; (3) adaptation to high vs low light and the tendency to be autotrophic vs mixotrophic; (4) cell motility; (5) environmental turbulence; (6) pigmentation quality; (7) temperature; (8) cell size; (9) relative growth rate; (10) relative production of bioactive compounds such as toxins or reactive oxygen species (ROS); (11) r vs K strategy; and (12) fate of the production in terms of grazing. The new mandala serves to highlight the differences and trade-offs between traits and/or environmental conditions, and illustrates some traits tend to track each other, a concept that may be helpful in trait-based modeling approaches. It is hoped that this new mandala captures some of our recent insight into phytoplankton physiology and functional traits, and has contemporary relevance in light of anthropogenic changes in nutrient form and ratio.

  4. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species

    Directory of Open Access Journals (Sweden)

    Middha Sumit

    2008-05-01

    Full Text Available Abstract Background The fibrinogen-like (FBG domain consists of approximately 200 amino acid residues, which has high sequence similarity to the C-terminal halves of fibrinogen β and γ chains. Fibrinogen-related proteins (FREPs containing one or more FBG domains are found universally in vertebrates and invertebrates. In invertebrates, FREPs are involved in immune responses and other aspects of physiology. To understand the complexity of this gene family in Drosophila, we analyzed FREPs in twelve Drosophila species. Results Using the genome data from 12 Drosophila species, we identified FBG domains in each species. The results show that the gene numbers in each species vary from 14 genes up to 43 genes. Using sequence profile analysis, we found that FBG domains have high sequence similarity and are highly conserved throughout. By comparison of structure and sequence conservation, some of the FBG domains in Drosophila melanogaster are predicted to function in recognition of carbohydrates and their derivatives on the surface of microorganisms in innate immunity. Conclusion Sequence and structural analyses show that FREP family across 12 Drosophila species contains conserved FBG domains. Expansion of the FREP families in Drosophila is mainly accounted by a major expansion of FBG domains.

  5. Twelve-Year Trends of PM10 and Visibility in the Hefei Metropolitan Area of China

    Directory of Open Access Journals (Sweden)

    Lin Huang

    2016-01-01

    Full Text Available China has been experiencing severe air pollution and previous studies have mostly focused on megacities and a few hot spot regions. Hefei, the provincial capital city of Anhui province, has a population of near 5 million in its metropolitan area, but its air quality has not been reported in literature. In this study, daily PM10 and visibility data in 2001–2012 were analyzed to investigate the air quality status as well as the twelve-year pollution trends in Hefei. The results reveal that Hefei has been suffering high PM10 pollution and low visibility during the study period. The annual average PM10 concentrations are 2~3 times of the Chinese Ambient Air Quality Standard. PM10 shows fluctuating variation in 2001–2007 and has a slightly decreasing trend after 2008. The annual average visibility range is generally lower than 7 km and shows a worsening trend from 2001 to 2006 followed by an improving trend from 2007 to 2012. Wind speed, precipitation, and relative humidity have negative effects on PM10 concentrations in Hefei, while temperature could positively or negatively affect PM10. The results provide a general understanding of the status and long-term trends of PM10 pollution and visibility in a typical second-tier city in China.

  6. Validation of Twelve Small Kepler Transiting Planets in the Habitable Zone

    CERN Document Server

    Torres, Guillermo; Fressin, Francois; Caldwell, Douglas A; Twicken, Joseph D; Ballard, Sarah; Batalha, Natalie M; Bryson, Stephen T; Ciardi, David R; Henze, Christopher E; Howell, Steve B; Isaacson, Howard T; Jenkins, Jon M; Muirhead, Philip S; Newton, Elisabeth R; Petigura, Erik A; Barclay, Thomas; Borucki, William J; Crepp, Justin R; Everett, Mark E; Horch, Elliott P; Howard, Andrew W; Kolbl, Rea; Marcy, Geoffrey W; McCauliff, Sean; Quintana, Elisa V

    2015-01-01

    We present an investigation of twelve candidate transiting planets from Kepler with orbital periods ranging from 34 to 207 days, selected from initial indications that they are small and potentially in the habitable zone (HZ) of their parent stars. The expected Doppler signals are too small to confirm them by demonstrating that their masses are in the planetary regime. Here we verify their planetary nature by validating them statistically using the BLENDER technique, which simulates large numbers of false positives and compares the resulting light curves with the Kepler photometry. This analysis was supplemented with new follow-up observations (high-resolution optical and near-infrared spectroscopy, adaptive optics imaging, and speckle interferometry), as well as an analysis of the flux centroids. For eleven of them (KOI-0571.05, 1422.04, 1422.05, 2529.02, 3255.01, 3284.01, 4005.01, 4087.01, 4622.01, 4742.01, and 4745.01) we show that the likelihood they are true planets is far greater than that of a false po...

  7. Measurement and analysis of angular velocity variations of twelve-cylinder diesel engine crankshaft

    Science.gov (United States)

    Bulatović, Ž. M.; Štavljanin, M. S.; Tomić, M. V.; Knežević, D. M.; Biočanin, S. Lj.

    2011-11-01

    This paper presents the procedures for measuring and analyzing the angular velocity variation of twelve-cylinder diesel engine crankshaft on its free end and on the power-output end. In addition, the paper deals with important aspects of the measurement of crankshaft torsional oscillations. The method is based on digital encoders placed at two distances, and one of them is a sensor not inserted directly on the shaft, i.e. a non-contact method with a toothed disc is used. The principle based on toothed disc is also used to measure the actual camshaft angular velocity of in-line compact high-pressure pump the engine is equipped with, and this paper aims to demonstrate the possibility of measuring the actual angular velocity of any rotating shaft in the engine, on which it is physically possible to mount a toothed disc. The method was created completely independently during long-range development and research tests of V46 family engines. This method is specific for its particular adaptability for use on larger engines with extensive vibrations and torsional oscillations. The main purpose of this paper is a practical contribution to all the more interesting research of the use of engine crankshaft angular velocity as a diagnostic tool for identifying the engine irregular running.

  8. Access to oral health services in children under twelve years of age in Peru, 2014

    Directory of Open Access Journals (Sweden)

    Akram Hernández-Vásquez

    2016-10-01

    Full Text Available The aim of the study was to explore the patterns of dental health services access in children under twelve years of age in Peru. Data from 25,285 children under 12 years who participated in the Demographic and Family Health Survey of 2014 were reviewed. An exploratory spatial analysis was performed to project the proportions of children with access to dental health services, according to national regions, type of health service and urban or rural place of residence. The results show that of the total sample, 26.7% had access to dental health services in the last six months, 39.6% belonged to the age group 0-4 years, 40.6% lived in the Andean region and 58.3% lived in urban areas. The regions of Huancavelica, Apurimac, Ayacucho, Lima and Pasco had the highest percentages of access nationwide. In conclusion, there is low access to dental health services in the population under 12 years of age in Peru. The spatial distribution of access to dental health services allows regions to be identified and grouped according to similar access patterns, in order to better focus public health actions.

  9. Synergy between Seeking Safety and Twelve-Step Affiliation on Substance Use Outcomes for Women

    Science.gov (United States)

    Morgan-Lopez, Antonio A.; Saavedra, Lissette M.; Hien, Denise A.; Campbell, Aimee N.; Wu, Elwin; Ruglass, Lesia

    2014-01-01

    Objective The Recovery Management paradigm provides a conceptual framework for the examination of joint impact of a focal treatment and post-treatment service utilization on substance abuse treatment outcomes. We test this framework by examining the interactive effects of a treatment for comorbid PTSD and substance use, Seeking Safety, and post-treatment Twelve-Step Affiliation (TSA) on alcohol and cocaine use. Method Data from 353 women in a six-site, randomized controlled effectiveness trial within the NIDA Clinical Trials Network were analyzed under latent class pattern mixture modeling. LCPMM was used to model variation in Seeking Safety by TSA interaction effects on alcohol and cocaine use. Results Significant reductions in alcohol use among women in Seeking Safety (compared to Health Education) were observed; women in the Seeking Safety condition who followed up with TSA had the greatest reductions over time in alcohol use. Reductions in cocaine use over time were also observed but did not differ between treatment conditions nor were there interactions with post-treatment TSA. Conclusions Findings advance understanding of the complexities for treatment and continuing recovery processes for women with PTSD and SUDs, and further support the chronic disease model of addiction. PMID:23558158

  10. Coréia aguda na gravidez Acute chorea in pregnancy: comments on twelve consecutive cases

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1967-12-01

    Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.Twelve consecutive cases of acute chorea occurring among 150.000 pregnant women (1/12.500 are reported. Most of the cases occurred from the fourth do the sixth month of the first pregnancy. The average duration of the symptoms was of three months and no one case of maternal death was verified in the group. The deliveries were spontaneous and normal in all the patients. Only one case of fetal death occurred in consequence of a hemorragic shock. Comments are made on the clinical, laboratorial and prognostic features of chorea gravidarum, being particulary focused the physiopathogenic problem of this condtion.

  11. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VIII. CATALOG OF TRANSIT TIMING MEASUREMENTS OF THE FIRST TWELVE QUARTERS

    Energy Technology Data Exchange (ETDEWEB)

    Mazeh, Tsevi; Nachmani, Gil; Holczer, Tomer; Sokol, Gil [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of Chicago, 5640 Ellis Ave., Chicago, IL 60637 (United States); Ford, Eric B.; Ragozzine, Darin [Astronomy Department, University of Florida, Gainesville, FL 32111 (United States); Sanchis-Ojeda, Roberto [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Rowe, Jason F.; Lissauer, Jack J. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Zucker, Shay [Department of Geophysical, Atmospheric and Planetary Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences Tel Aviv University, 69978 Tel Aviv (Israel); Agol, Eric [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Carter, Joshua A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Quintana, Elisa V. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Welsh, William [Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 (United States)

    2013-10-01

    Following the works of Ford et al. and Steffen et al. we derived the transit timing of 1960 Kepler objects of interest (KOIs) using the pre-search data conditioning light curves of the first twelve quarters of the Kepler data. For 721 KOIs with large enough signal-to-noise ratios, we obtained also the duration and depth of each transit. The results are presented as a catalog for the community to use. We derived a few statistics of our results that could be used to indicate significant variations. Including systems found by previous works, we have found 130 KOIs that showed highly significant times of transit variations (TTVs) and 13 that had short-period TTV modulations with small amplitudes. We consider two effects that could cause apparent periodic TTV—the finite sampling of the observations and the interference with the stellar activity, stellar spots in particular. We briefly discuss some statistical aspects of our detected TTVs. We show that the TTV period is correlated with the orbital period of the planet and with the TTV amplitude.

  12. Peer teaching in medical education: twelve reasons to move from theory to practice.

    Science.gov (United States)

    Ten Cate, Olle; Durning, Steven

    2007-09-01

    To provide an estimation of how often peer teaching is applied in medical education, based on reports in the literature and to summarize reasons that support the use of this form of teaching. We surveyed the 2006 medical education literature and categorised reports of peer teaching according to educational distance between students teaching and students taught, group size, and level of formality of the teaching. Subsequently, we analysed the rationales for applying peer teaching. Most reports were published abstracts in either Medical Education's annual feature 'Really Good Stuff' or the AMEE's annual conference proceedings. We identified twelve distinct reasons to apply peer teaching, including 'alleviating faculty teaching burden', 'providing role models for junior students', 'enhancing intrinsic motivation' and 'preparing physicians for their future role as educators'. Peer teaching appears to be practiced often, but many peer teaching reports do not become full length journal articles. We conclude that specifically 'near-peer teaching' appears beneficial for student teachers and learners as well as for the organisation. The analogy of the 'journeyman', as intermediate between 'apprentice' and 'master', with both learning and teaching tasks, is a valuable but yet under-recognized source of education in the medical education continuum.

  13. Heterochromatic banding patterns on chromosomes of twelve weevil species (Insecta, Coleoptera, Curculionoidea: Apionidae, Curculionidae).

    Science.gov (United States)

    Holecová, Milada; Rozek, Maria; Lachowska, Dorota

    2002-01-01

    The C-banding patterns of twelve weevil species are presented. The obtained results confirm the existence of two groups of species: with a small or large amount of heterochromatin in the karyotype. The first group comprises seven species (Apionidae: Holotrichapion pisi; Curculionidae: Phyllobius urticae, Ph. pyri, Ph. maculicornis, Tanymecus palliatus, Larinodontes turbinatus, Cionus tuberculosus). In weevils with a small amount of heterochromatin, tiny grains on the nucleus in interphase are visible, afterwards in mitotic and meiotic prophase appearing as dark dots. The absence of C-bands does not indicate a lack of heterochromatin but heterochromatic regions are sometimes so small that the condensation is not visible during the cell cycle. The second group comprises five species (Otiorhynchus niger, O. morio, Polydrusus corruscus, Barypeithes chevrolati, Nedyus quadrimaculatus) which possess much larger heteropicnotic parts of chromosomes visible during all nuclear divisions. The species examined have paracentromeric C-bands on autosomes and the sex chromosome X, except for Otiorhynchus niger, which also has an intercalary bands on one pair of autososomes. All the species examined differ in the size of segments of constitutive heterochromatin. The y heterochromosome is dot-like and wholly euchromatic in all the studied species.

  14. In vitro antibacterial and antifungal activities of twelve sponges collected from the Anambas Islands, Indonesia

    Directory of Open Access Journals (Sweden)

    Masteria Yunovilsa Putra

    2016-09-01

    Full Text Available Objective: To evaluate antimicrobial activities in methanolic extracts of twelve sponges collected from the Anambas Islands, Indonesia. Methods: The antibacterial activity of methanolic extracts was tested against two Grampositive bacteria, viz. Bacillus subtilis (ATCC 6633 and Staphylococcus aureus (ATCC 25923, and two Gram-negative bacteria, viz. Eschericia coli (ATCC 25922 and Vibrio anguillarum (ATCC 19264 using the disk diffusion assay. The antifungal activity was similarly tested against Candida albicans (ATCC 10231 and Aspergillus niger (ATCC 16404. The minimum inhibitory concentrations of promising sponges extracts were determined by the microdilution technique. Results: All the sponge species in this study showed antimicrobial activities against at least one of the test strains. Antibacterial activities were observed in 66.7% of the sponges extracts, while 30.0% of the extracts exhibited antifungal activities. Among them, the extracts of the sponges Stylissa massa and Axinyssa sp. were the most active against four tested bacteria and the yeast Candida albicans. The sponge Theonella swinhoei and two species of Xestospongia also displayed significant activities against two fungal pathogens Candida albicans and Aspergillus niger. Conclusions: Antimicrobial activities were demonstrated in extracts from various marine sponges collected from the Anambas Islands, Indonesia. The most promising sponges among them were Stylissa massa and Axinyssa sp. This is the first report of antimicrobial activity in extracts of marine sponges from the Indonesian Anambas Islands.

  15. The SLUGGS Survey: Kinematics for over 2500 Globular Clusters in Twelve Early-type Galaxies

    CERN Document Server

    Pota, Vincenzo; Romanowsky, Aaron J; Brodie, Jean P; Spitler, Lee R; Strader, Jay; Foster, Caroline; Arnold, Jacob A; Benson, Andrew; Blom, Christina; Hargis, Jonathan R; Rhode, Katherine L; Usher, Christopher

    2012-01-01

    We present a spectro-photometric survey of 2522 extragalactic globular clusters (GCs) around twelve early-type galaxies, nine of which have not been published previously. Combining space-based and multi-colour wide field ground-based imaging, with spectra from the Keck DEIMOS instrument, we obtain an average of 160 GC radial velocities per galaxy, with a high velocity precision of 15 km/s per GC. After studying the photometric properties of the GC systems, such as their spatial and colour distributions, we focus on the kinematics of metal-poor (blue) and metal-rich (red) GC subpopulations to an average distance of ~8 effective radii from the galaxy centre. Our results show that for some systems the bimodality in GC colour is also present in GC kinematics. The kinematics of the red GC subpopulations are strongly coupled with the host galaxy stellar kinematics. The blue GC subpopulations are more dominated by random motions, especially in the outer regions, and decoupled from the red GCs. Peculiar GC kinematic ...

  16. Whole-Proteome Analysis of Twelve Species of Alphaproteobacteria Links Four Pathogens

    Directory of Open Access Journals (Sweden)

    Yunyun Zhou

    2013-11-01

    Full Text Available Thousands of whole-genome and whole-proteome sequences have been made available through advances in sequencing technology, and sequences of millions more organisms will become available in the coming years. This wealth of genetic information will provide numerous opportunities to enhance our understanding of these organisms including a greater understanding of relationships among species. Researchers have used 16S rRNA and other gene sequences to study the evolutionary origins of bacteria, but these strategies do not provide insight into the sharing of genes among bacteria via horizontal transfer. In this work we use an open source software program called pClust to cluster proteins from the complete proteomes of twelve species of Alphaproteobacteria and generate a dendrogram from the resulting orthologous protein clusters. We compare the results with dendrograms constructed using the 16S rRNA gene and multiple sequence alignment of seven housekeeping genes. Analysis of the whole proteomes of these pathogens grouped Rickettsia typhi with three other animal pathogens whereas conventional sequence analysis failed to group these pathogens together. We conclude that whole-proteome analysis can give insight into relationships among species beyond their phylogeny, perhaps reflecting the effects of horizontal gene transfer and potentially providing insight into the functions of shared genes by means of shared phenotypes.

  17. INCIDENCE AND SURVIVAL OF LIPOLYTIC ORGANISMS MONITORED FOR TWELVE MONTHS IN DOMESTIC WASTEWATER AND RECEIVING STREAM

    Directory of Open Access Journals (Sweden)

    Adebowale Odeyemi

    2013-10-01

    Full Text Available The incidence and survival of lipolytic organisms in domestic wastewater and receiving stream were monitored over 12 months. The average total bacterial count in the wastewater samples reduced in April and November by 24.2% and 41.6% respectively. There was also a reduction of 42.3% and 60.1% in the load in the receiving stream in August and July. Subsequently, at 5m downstream from the entry of the wastewater the microbial load reduced in March (19.2% and June (19.2%. However, the occurrence of coliforms was more affected in the months of May (53% to July (87.2%. At 5m and 10m downstream the coliform population reduced by 27.9% and 30.1% respectively. Of the twelve (12 bacterial isolates obtained at the exit of the wastewater into the receiving stream, only four (4 were found to possess lipolytic activity. These include the species of Enterococcus, Klebsiella, Pseudomonas and Staphylococcus. There was no significant difference in the amount of nutrients found in the domestic wastewater and receiving stream during the months. This paper also discusses the implication of disposing large amounts of wastewater effluents into the receiving water and the need to remedy and minimize the overall impact of such pollution on the environment.

  18. Interaction and cooperative effort among scientific societies. Twelve years of COSCE.

    Science.gov (United States)

    Martín, Nazario; Andradas, Carlos

    2015-12-01

    The evolution of knowledge and technology in recent decades has brought profound changes in science policy, not only in the countries but also in the supranational organizations. It has been necessary, therefore, to adapt the scientific institutions to new models in order to achieve a greater and better communication between them and the political counterparts responsible for defining the general framework of relations between science and society. The Federationon of Scientific Societies of Spain (COSCE, Confederación de Sociedades Científicas de España) was founded in October 2003 to respond to the urgent need to interact with the political institutions and foster a better orientation in the process of making decisions about the science policy. Currently COSCE consists of over 70 Spanish scientific societies and more than 40,000 scientists. During its twelve years of active life, COSCE has developed an intense work of awareness of the real situation of science in Spain by launching several initiatives (some of which have joined other organizations) or by joining initiatives proposed from other groups related to science both at the Spanish level and at the European and non-European scenarios. [Int Microbiol 18(4): 245-251 (2015)].

  19. Ecological conversion efficiency and its influencers in twelve species of fish in the Yellow Sea Ecosystem

    Science.gov (United States)

    Tang, Qisheng; Guo, Xuewu; Sun, Yao; Zhang, Bo

    2007-09-01

    The ecological conversion efficiencies in twelve species of fish in the Yellow Sea Ecosystem, i.e., anchovy ( Engraulis japonicus), rednose anchovy ( Thrissa kammalensis), chub mackerel ( Scomber japonicus), halfbeak ( Hyporhamphus sajori), gizzard shad ( Konosirus punctatus), sand lance ( Ammodytes personatus), red seabream ( Pagrus major), black porgy ( Acanthopagrus schlegeli), black rockfish ( Sebastes schlegeli), finespot goby ( Chaeturichthys stigmatias), tiger puffer ( Takifugu rubripes), and fat greenling ( Hexagrammos otakii), were estimated through experiments conducted either in situ or in a laboratory. The ecological conversion efficiencies were significantly different among these species. As indicated, the food conversion efficiencies and the energy conversion efficiencies varied from 12.9% to 42.1% and from 12.7% to 43.0%, respectively. Water temperature and ration level are the main factors influencing the ecological conversion efficiencies of marine fish. The higher conversion efficiency of a given species in a natural ecosystem is acquired only under the moderate environment conditions. A negative relationship between ecological conversion efficiency and trophic level among ten species was observed. Such a relationship indicates that the ecological efficiency in the upper trophic levels would increase after fishing down marine food web in the Yellow Sea ecosystem.

  20. Differences in antimicrobial activity of chlorine against twelve most prevalent poultry-associated Salmonella serotypes.

    Science.gov (United States)

    Paul, Narayan C; Sullivan, Tarah S; Shah, Devendra H

    2017-06-01

    Chlorine is the most widely used carcass sanitizer in poultry processing in the USA. The objective of this study was to determine the effects of varying concentrations of organic matter on the susceptibility of twelve most prevalent poultry-associated Salmonella serotypes (MPPSTs) to chlorine. To mimic the microenvironment of the water used for immersion chilling, we manipulated organic matter contamination levels in pre-chilled (pH∼6, T∼4 °C) chlorinated (50 ppm) water using varying concentrations (0, 1, 2, 3, 4, and 5%) of chicken-meat-extract (CME) produced from frozen chicken carcasses. This CME-based in vitro model was challenged with ∼1 × 10(5) CFUs of each MPPST isolate and the bacterial survival was tested at 5, 30, 60 and 90 min post-challenge. In this model, the decimal reduction time (D90-values) of each MPPST was linearly correlated with the concentration of CME. Significant inter-serotype differences in the D90-values were observed. The results show that the pH, concentration of total- and free-chlorine were also linearly correlated with the presence of CME in a concentration-dependent manner. The findings of this study indicate that the serotype and the levels of organic matter contamination significantly influence Salmonella survival and that both variables should be included in models that predict effectiveness of chlorine treatment in immersion chilling.

  1. Alcoholics Anonymous and twelve-step recovery: a model based on social and cognitive neuroscience.

    Science.gov (United States)

    Galanter, Marc

    2014-01-01

    In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change. Literature review and hypothesis development. Pertinent aspects of the neural impact of drugs of abuse are summarized. After this, research regarding specific brain sites, elucidated primarily by imaging techniques, is reviewed relative to the following: Mirroring and mentalizing are described in relation to experimentally modeled studies on empathy and mutuality, which may parallel the experiences of social interaction and influence on AA members. Integration and retrieval of memories acquired in a setting like AA are described, and are related to studies on storytelling, models of self-schema development, and value formation. A model for ascription to a Higher Power is presented. The phenomena associated with AA reflect greater complexity than the empirical studies on which this article is based, and certainly require further elucidation. Despite this substantial limitation in currently available findings, there is heuristic value in considering the relationship between the brain-based and clinical phenomena described here. There are opportunities for the study of neuroscientific correlates of Twelve-Step-based recovery, and these can potentially enhance our understanding of related clinical phenomena. © American Academy of Addiction Psychiatry.

  2. Deathly silence and apocalyptic noise: Observations on the soundscape of the Book of the Twelve

    Directory of Open Access Journals (Sweden)

    Aaron Schart

    2010-03-01

    Full Text Available This paper proposes a reading of the Book of the Twelve (used interchangeably with �Twelve� and �Book� for convenience that concentrates on the sound that is included in the description of the world of the text. Three onomatopoeic devices are singled out. First, the mourning cry h�y is considered. This interjection is used differently in several of the writings: in Amos (5:18; 6:1 the prophet cries out in compassion with the addressees. By contrast, in Nahum 3:1 and Habakkuk 2:6�19, h�y is uttered in a mood of mockery. In Zechariah 2:10 a third, joyful h�y is used. It appears that the different usages cohere nicely with the overall structure of the Book of the Twelve. Secondly, the interjection has likewise shows different usages. In Amos 6:10 and 8:3, it simulates the last breath of Israelites dying when the land is devastated. By contrast, in Habakkuk 2:20, Zephaniah 1:7 and Zechariah 2:17, the addressees are directed to be silent before YHWH. This command should be perceived as an act of reverence. Again, the sequence of the occurrences coheres with the overall structure of the Book of the Twelve. Of special relevance is that the last three instances build a frame around the Babylonian exile, which lies between Zephaniah and Haggai. The third example is the phrase ham�n�m, ham�n�m in Joel 4:14. The author employs an irregular double plural to construe this place as the loudest spot (�apocalyptic noise� within the Twelve.Setu sa go tiba le modumo wa aphokhaliptiki: Ditemogo ka medumo ya Puku ya ba LesomepediPampiri ye e �i�inya go balwa ga Puku ya ba Lesomepedi (yeo e ka nogo bit�wa �Lesomepedi� goba �Puku� go bebofat�a ditaba ka go gatelela modumo wo o lego ka gare ga tlhaloso ya lefase la go tswala dingwalo t�e. Ditsela t�e tharo t�a onomathopoiki di bewa pepeneng. La mathomo, go �et�wa sello sa mahloko sa h?y. Lelahlelwa le le �omi�wa ka go fapana mo dingwalong t�e mmalwa: go Amosi

  3. Fate of the conformal fixed point with twelve massless fermions and SU(3) gauge group

    Science.gov (United States)

    Fodor, Zoltan; Holland, Kieran; Kuti, Julius; Mondal, Santanu; Nogradi, Daniel; Wong, Chik Him

    2016-11-01

    We report new results on the conformal properties of an important strongly coupled gauge theory, a building block of composite Higgs models beyond the Standard Model. With twelve massless fermions in the fundamental representation of the SU(3) color gauge group, an infrared fixed point (IRFP) of the β -function was recently reported in the theory [A. Cheng, A. Hasenfratz, Y. Liu, G. Petropoulos, and D. Schaich, J. High Energy Phys. 05 (2014) 137] with uncertainty in the location of the critical gauge coupling inside the narrow [6.0 fixed point and scale invariance in the theory with model-building implications. Using the exact same renormalization scheme as the previous study, we show that no fixed point of the β -function exists in the reported interval. Our findings eliminate the only seemingly credible evidence for conformal fixed point and scale invariance in the Nf=12 model whose infrared properties remain unresolved. The implications of the recently completed 5-loop QCD β -function for arbitrary flavor number are discussed with respect to our work.

  4. Twelve tips for creating trigger images for problem-based learning cases.

    Science.gov (United States)

    Azer, Samy A

    2007-03-01

    A trigger is the starting point of problem-based learning (PBL) cases. It is usually in the form of 5-6 text lines that provide the key information about the main character (usually the patient), including 3-4 of patient's presenting problems. In addition to the trigger text, most programs using PBL include a visual trigger. This might be in the form of a single image, a series of images, a video clip, a cartoon, or even one of the patient's investigation results (e.g. chest X-ray, pathology report, or urine sample analysis). The main educational objectives of the trigger image are as follows: (1) to introduce the patient to the students; (2) to enhance students' observation skills; (3) to provide them with new information to add to the cues obtained from the trigger text; and (4) to stimulate students to ask questions as they develop their enquiry plan. When planned and delivered effectively, trigger images should be engaging and stimulate group discussion. Understanding the educational objectives of using trigger images and choosing appropriate images are the keys for constructing successful PBL cases. These twelve tips highlight the key steps in the successful creation of trigger images.

  5. Emetic and Electric Shock Alcohol Aversion Therapy: Six- and Twelve-Month Follow-Up.

    Science.gov (United States)

    Cannon, Dale S.; Baker, Timothy B.

    1981-01-01

    Follow-up data are presented for 6- and 12-months on male alcoholics (N=20) who received either a multifaceted inpatient alcoholism treatment program alone (controls) or emetic or shock aversion therapy in addition to that program. Both emetic and control subjects compiled more days of abstinence than shock subjects. (Author)

  6. Improving Comparability Of Survey Results Through Ex-Post Harmonisation A Case Study With Twelve European National Travel Surveys

    DEFF Research Database (Denmark)

    Christensen, Linda; Hubert, Jean-Paul; Järvi, Tuuli

    that reflect behavioural differences rather than methodological ones, in the context of the COST Action SHANTI (Survey Harmonisation with New Technologies Improvement, TUD0804) an ex-post harmonisation approach was developed using microdata from twelve European NTS’s. The paper presents both concept and basic...

  7. Twelve Years of Education and Public Outreach with the Fermi Gamma-ray Space Telescope

    Science.gov (United States)

    Cominsky, Lynn R.; McLin, K. M.; Simonnet, A.; Fermi E/PO Team

    2013-04-01

    During the past twelve years, NASA's Fermi Gamma-ray Space Telescope has supported a wide range of Education and Public Outreach (E/PO) activities, targeting K-14 students and the general public. The purpose of the Fermi E/PO program is to increase student and public understanding of the science of the high-energy Universe, through inspiring, engaging and educational activities linked to the mission’s science objectives. The E/PO program has additional more general goals, including increasing the diversity of students in the Science, Technology, Engineering and Mathematics (STEM) pipeline, and increasing public awareness and understanding of Fermi science and technology. Fermi's multi-faceted E/PO program includes elements in each major outcome category: ● Higher Education: Fermi E/PO promotes STEM careers through the use of NASA data including research experiences for students and teachers (Global Telescope Network), education through STEM curriculum development projects (Cosmology curriculum) and through enrichment activities (Large Area Telescope simulator). ● Elementary and Secondary education: Fermi E/PO links the science objectives of the Fermi mission to well-tested, customer-focused and NASA-approved standards-aligned classroom materials (Black Hole Resources, Active Galaxy Education Unit and Pop-up book, TOPS guides, Supernova Education Unit). These materials have been distributed through (Educator Ambassador and on-line) teacher training workshops and through programs involving under-represented students (after-school clubs and Astro 4 Girls). ● Informal education and public outreach: Fermi E/PO engages the public in sharing the experience of exploration and discovery through high-leverage multi-media experiences (Black Holes planetarium and PBS NOVA shows), through popular websites (Gamma-ray Burst Skymap, Epo's Chronicles), social media (Facebook, MySpace), interactive web-based activities (Space Mysteries, Einstein@Home) and activities by

  8. Relative peripheral refraction in children: twelve-month changes in eyes with different ametropias.

    Science.gov (United States)

    Lee, Tsui-Tsui; Cho, Pauline

    2013-05-01

    To determine the peripheral refraction of children with different types of ametropias and to evaluate the relationship between central refractive changes, baseline relative peripheral refraction (RPR) and changes in RPR over a 12-month monitoring period. Cycloplegic central and peripheral refraction were performed biannually on the right eyes of children aged 6-9 for 12 months, using an open-view autorefractor. Peripheral refraction were measured along 10°, 20° and 30° from central fixation in both nasal and temporal fields. Refractive data were transposed into M, J0 and J45 vectors for analyses. RPR was determined by subtracting the central measurement from each peripheral measurement. Hyperopic eyes showed relative peripheral myopia while myopic eyes had relative hyperopia across the central 60° horizontal field at baseline. Emmetropic eyes had relative myopia within but showed relative hyperopia beyond the central 30° field. However, there was no significant correlation between central refractive changes and baseline RPR or between changes in central refraction and RPR over twelve months in any refractive groups. Correlations between changes in PR and central myopic shift were found mainly in the nasal field in different groups. In the subgroup analysis on the initially emmetropic and the initially myopic groups, the subgroups with faster myopic progression did not have significantly different RPR from the subgroups with slower progression. The RPR pattern of the initially emmetropic and the initially myopic groups became more asymmetric at the end of the study period with a larger increase in relative hyperopia in the temporal field. RPR patterns were different among hyperopic, emmetropic and myopic eyes. However, baseline RPR and changes in RPR cannot predict changes in central refraction over time. Our results did not provide evidence to support the hypothesis of RPR as a causative factor for myopic central refractive changes in children. Ophthalmic

  9. Computational study of the structural and vibrational properties of ten and twelve vertex closo-carboranes

    Energy Technology Data Exchange (ETDEWEB)

    Salam, A.; Deleuze, M.S.; Francois, J.-P

    2003-01-01

    Calculations using ab initio Hartree-Fock and Density Functional theories, the latter employing the B3LYP functional, in combination with a number of large standard basis sets ranging from 6-31G** to cc-pVDZ, have been performed on a series of ten and twelve vertex closo-carborane isomer species. Results obtained for optimized structural parameters and molecular properties are presented for 1,2-, 1,6- and 1,10-C{sub 2}B{sub 8}H{sub 10} and 1,2-, 1,7- and 1,12-C{sub 2}B{sub 10}H{sub 12} and compared, where possible, with both earlier theoretical data and experiment. Irrespective of the model chemistry chosen, the para-isomer in each class of carborane cluster is found to be the most stable species, corresponding to a structure in which the cage carbon atoms are positioned at diametrically opposed ends of the respective polyhedron. Boron-hydrogen and carbon-hydrogen bond lengths are found to change little on going from isomers of one particular cage size to another, supporting analogous conclusions previously established for small closo-carborane cages possessing five, six and seven vertices. The calculated vibrational spectra of the isomers of both decacarborane and dodecacarborane are seen to be similar to each other and reflect a high degree of rigidity within each cluster. Key polyhedral skeletal breathing modes along with characteristic boron-hydrogen and carbon-hydrogen stretching frequencies are identified in the spectra and compared with experiment. Thermochemical data relating to each species are also analyzed.

  10. Indifference to pain syndrome in a twelve-year-old boy (case report

    Directory of Open Access Journals (Sweden)

    Baghdadi T

    2007-08-01

    Full Text Available Background: People vary greatly in their response to painful stimuli, from those with a low pain threshold to those with indifference to pain. However, insensitivity to pain is a rare disorder, characterized by the lack of usual subjective and objective responses to noxious stimuli. Patients who have congenital indifference to pain sustain painless injuries beginning in infancy, but have sensory responses that are otherwise normal on examination. Perception of passive movement, joint position, and vibration is normal in these patients, as are tactile thresholds and light touch perception. Case report: A twelve-year-old boy was admitted to the hospital for a painless deformity, degeneration in both knees and a neglected femoral neck fracture that was inappropriately painless. Further examination revealed normal sensory responses, perception of passive movement, joint position, vibration tactile thresholds and light touch perception. Spinal cord and brain MRI were normal as was the electromyography and nerve conduction velocity (EMG/NCV examination. There was no positive family history for this disorder. Conclusion: The deficits present in the different pain insensitivity syndromes provide insight into the complex anatomical and physiological nature of pain perception. Reports on pain asymbolia, in which pain is perceived but does not cause suffering, and related cortical conditions illustrate that there can be losses that independently involve either the sensory-discriminative component or the affective-motivational component of pain perception, thus highlighting their different anatomical localization. The paucity of experience with this entity and the resultant diagnostic problems, the severity of the associated disabling arthropathy and underscore the importance of this case report of indifference to pain.

  11. Removal of trace level amounts of twelve sulfonamides from drinking water by UV-activated peroxymonosulfate.

    Science.gov (United States)

    Cui, Changzheng; Jin, Lei; Jiang, Lei; Han, Qi; Lin, Kuangfei; Lu, Shuguang; Zhang, Dong; Cao, Guomin

    2016-12-01

    Trace levels of residual antibiotics in drinking water may threaten public health and become a serious problem in modern society. In this work, we investigated the degradation of twelve sulfonamides (SAs) at environmentally relevant trace level concentrations by three different methods: ultraviolet (UV) photolysis, peroxymonosulfate (PMS) oxidation, and UV-activated PMS (UV/PMS). Sulfaguanidine, sulfadiazine, sulfamerazine, sulfamethazine, sulfathiazole, sulfamethoxydiazine, and sulfadimethoxine were be effectively removed by direct UV photolysis and PMS oxidation. However, sulfanilamide, sulfamethizole, sulfamethoxazole, sulfisoxazole, and sulfachloropyridazine were not completely degraded, despite prolonging the UV irradiation time to 30min or increasing the PMS concentration to 5.0mg·L(-1). UV/PMS provided more thorough elimination of SAs, as demonstrated by the complete removal of 200ng·L(-1) of all SAs within 5min at an initial PMS concentration of 1.0mg·L(-1). UV/PMS promoted SA decomposition more efficiently than UV photolysis or PMS oxidation alone. Bicarbonate concentration and pH had a negligible effect on SA degradation by UV/PMS. However, humic acid retarded the process. Removal of 200ng·L(-1) of each SA from a sample of sand-filtered effluent from a drinking water treatment plant (DWTPs) was quickly and completely achieved by UV/PMS. Meanwhile, about 41% of the total organic carbon (TOC) was eliminated. Scavenging experiments showed that sulfate radical (SO4(-)) was the predominant species involved in the degradation. It is concluded that UV/PMS is a rapid and efficient method for removing trace-level SAs from drinking water. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. A survey of innovation through duplication in the reduced genomes of twelve parasites.

    Directory of Open Access Journals (Sweden)

    Jeremy D DeBarry

    Full Text Available We characterize the prevalence, distribution, divergence, and putative functions of detectable two-copy paralogs and segmental duplications in the Apicomplexa, a phylum of parasitic protists. Apicomplexans are mostly obligate intracellular parasites responsible for human and animal diseases (e.g. malaria and toxoplasmosis. Gene loss is a major force in the phylum. Genomes are small and protein-encoding gene repertoires are reduced. Despite this genomic streamlining, duplications and gene family amplifications are present. The potential for innovation introduced by duplications is of particular interest. We compared genomes of twelve apicomplexans across four lineages and used orthology and genome cartography to map distributions of duplications against genome architectures. Segmental duplications appear limited to five species. Where present, they correspond to regions enriched for multi-copy and species-specific genes, pointing toward roles in adaptation and innovation. We found a phylum-wide association of duplications with dynamic chromosome regions and syntenic breakpoints. Trends in the distribution of duplicated genes indicate that recent, species-specific duplicates are often tandem while most others have been dispersed by genome rearrangements. These trends show a relationship between genome architecture and gene duplication. Functional analysis reveals: proteases, which are vital to a parasitic lifecycle, to be prominent in putative recent duplications; a pair of paralogous genes in Toxoplasma gondii previously shown to produce the rate-limiting step in dopamine synthesis in mammalian cells, a possible link to the modification of host behavior; and phylum-wide differences in expression and subcellular localization, indicative of modes of divergence. We have uncovered trends in multiple modes of duplicate divergence including sequence, intron content, expression, subcellular localization, and functions of putative recent duplicates that

  13. Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.

    Science.gov (United States)

    De, Rishika; Hu, Ting; Moore, Jason H; Gilbert-Diamond, Diane

    2015-01-01

    Recent findings have reemphasized the importance of epistasis, or gene-gene interactions, as a contributing factor to the unexplained heritability of obesity. Network-based methods such as statistical epistasis networks (SEN), present an intuitive framework to address the computational challenge of studying pairwise interactions between thousands of genetic variants. In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18). We used information gain measures to identify all SNP-SNP interactions among and between these genes that were related to obesity (BMI > 30 kg/m(2)) within the Framingham Heart Study Cohort; interactions exceeding a certain threshold were used to build an SEN. We also quantified whether interactions tend to occur more between SNPs from the same gene (dyadicity) or between SNPs from different genes (heterophilicity). We identified a highly connected SEN of 709 SNPs and 1241 SNP-SNP interactions. Combining the SEN framework with dyadicity and heterophilicity analyses, we found 1 dyadic gene (TMEM18, P-value = 0.047) and 3 heterophilic genes (KCTD15, P-value = 0.045; SH2B1, P-value = 0.003; and TMEM18, P-value = 0.001). We also identified a lncRNA SNP (rs4358154) as a key node within the SEN using multiple network measures. This study presents an analytical framework to characterize the global landscape of genetic interactions from genome-wide arrays and also to discover nodes of potential biological significance within the identified network.

  14. Thermal environment in eight low-energy and twelve conventional Finnish houses.

    Science.gov (United States)

    Kähkönen, Erkki; Salmi, Kari; Holopainen, Rauno; Pasanen, Pertti; Reijula, Kari

    2015-11-01

    We assessed the thermal environment of eight recently built low-energy houses and twelve conventional Finnish houses. We monitored living room, bedroom and outdoor air temperatures and room air relative humidity from June 2012 to September 2013. Perceived thermal environment was evaluated using a questionnaire survey during the heating, cooling and interim seasons. We compared the measured and perceived thermal environments of the low-energy and conventional houses. The mean air temperature was 22.8 °C (21.9-23.8 °C) in the low-energy houses, and 23.3 °C (21.4-26.5 °C) in the conventional houses during the summer (1. June 2013-31. August 2013). In the winter (1. December 2012-28. February 2013), the mean air temperature was 21.3 °C (19.8-22.5 °C) in the low-energy houses, and 21.6 °C (18.1-26.4 °C) in the conventional houses. The variation of the air temperature was less in the low-energy houses than that in the conventional houses. In addition, the occupants were on average slightly more satisfied with the indoor environment in the low-energy houses. However, there was no statistically significant difference between the mean air temperature and relative humidity of the low-energy and conventional houses. Our measurements and surveys showed that a good thermal environment can be achieved in both types of houses.

  15. Phytochemical screening of twelve species of phytoplankton isolated from Arabian Sea coast

    Directory of Open Access Journals (Sweden)

    Sushanth Vishwanath Rai

    2015-11-01

    Full Text Available Objective: To analyze the phytochemicals in twelve species of marine phytoplankton. Methods: Total phenolic content of methanol extract was estimated by the Folin-Ciocalteu method. Total flavonoid content of the methanol extarct was determined by aluminium chloride method. Chlorophylls, β-carotene and astaxanthin were estimated by acetone extraction method. Vitamin C was determined by dinitrophenyl-hydrazine method. Phycobiliproteins such as allophycocyanin, phycocyanin and phycoerythrin in the aqueous extracts were determined. Results: Total phenolics varied from 5.41 mg gallic acid equivalents/g dry weight (DW in Phormidium corium (P. corium to 17.37 mg gallic acid equivalents/g DW in Oscillatoria fremyii (O. fremyii. Total flavonoids ranged between 0.74 mg quercetin equivalent/g DW in P. corium and 9.87 mg quercetin equivalent/g DW in Nannochloropsis oceanica. Chlorophyll-a pigment was high in Chaetoceros calcitrans (C. calcitrans (15.51 mg/g DW and low in P. corium (1.08 mg/g DW. Chlorophyll-c ranged between 0.07 mg/g DW in Nannochloropsis oceanica and 4.62 mg/g DW in C. calcitrans. High contents of β-carotene and astaxanthin were found in C. calcitrans and low in P. corium which ranged from 0.33 to 10.03 mg/g DW and 0.18 to 3.85 mg/g DW, respectively. Vitamin C content varied from 0.50 mg/g DW in C. calcitrans to 1.51 mg/g DW in Phormidium tenue. O. fremyii showed highest total phycobiliproteins of 317.05 mg/g DW. High contents of allophycocyanin and phycocyanin were found in O. fremyii, whereas high contents of phycoerythrin were found in Oscillatoria sancta. All the three phycobiliproteins were low in Chroococcus turgidus. Conclusions: Marine phytoplankton are one of the natural sources providing novel biologically active compounds with potential for pharmaceutical applications.

  16. Oxidative stress & male infertility.

    Science.gov (United States)

    Makker, Kartikeya; Agarwal, Ashok; Sharma, Rakesh

    2009-04-01

    The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a new and important cause has been identified: oxidative stress. Oxidative stress is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body. It is a powerful mechanism that can lead to sperm damage, deformity and eventually, male infertility. This review discusses the physiological need for ROS and their role in normal sperm function. It also highlights the mechanism of production and the pathophysiology of ROS in relation to the male reproductive system and enumerate the benefits of incorporating antioxidants in clinical and experimental settings.

  17. Cytogenetic of Male Infertility

    Directory of Open Access Journals (Sweden)

    Lutfiye Ozpak

    2011-08-01

    Full Text Available Infertility by definition, is not to get pregnant within one year of regular sexual relationship without protection, affects 15-20% of reproductive age couples. Approximately 30% of infertility cases are male originated. Male infertility is caused by endocrine-related genetic defects affecting urogenital system function. These defects adversely affect subsequent spermatogenesis, sexual function, fertility, early embryonic stage of sexual maturation. Autosomal and gonosomal, numerical and structural chromosome abnormalities and related syndromes rank at the top causes of male infertility. Similar chromosome abnormalities are detected in male infertility and as the rate of these abnormalities increase, it was found to reduce sperm count especially in azospermic and oligozoospermic men. [Archives Medical Review Journal 2011; 20(4.000: 230-245

  18. Males and Eating Disorders

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues Males and Eating Disorders Past Issues / Spring 2008 Table of Contents For ... this page please turn Javascript on. Photo: PhotoDisc Eating disorders primarily affect girls and women, but boys and ...

  19. Male Breast Cancer

    Science.gov (United States)

    ... breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or Klinefelter's syndrome. Treatment for male breast cancer is usually ...

  20. Thyroid and male reproduction

    Directory of Open Access Journals (Sweden)

    Anand Kumar

    2014-01-01

    Full Text Available Male reproduction is governed by the classical hypothalamo-hypophyseal testicular axis: Hypothalamic gonadotropin releasing hormone (GnRH, pituitary luteinizing hormone (LH and follicle stimulating hormone (FSH and the gonadal steroid, principally, testosterone. Thyroid hormones have been shown to exert a modulatory influence on this axis and consequently the sexual and spermatogenic function of man. This review will examine the modulatory influence of thyroid hormones on male reproduction.

  1. Dysgenetic male pseudohermaphroditism

    OpenAIRE

    Proença, E; Freitas, S.; Fonseca, M.; Figueiredo, S; Rodrigues, C.

    2001-01-01

    Acta Med Port. 2001 Sep-Dec;14(5-6):511-4. [Dysgenetic male pseudohermaphroditism] [Article in Portuguese] Proença E, Freitas S, Fonseca M, Figueiredo S, Rodrigues C. Serviço de Cirurgia Pediátrica, Hospital Maria Pia, Porto. Abstract Dysgenetic male pseudohermaphroditism is the result of a defect of testis development that encompasses a large clinical heterogeneity. It is characterized by bilateral dysgenetic testis, absence of mullerian regression, ambiguous genitalia and/...

  2. Risk Factors for Injury Associated with Low, Moderate, and High Mileage Road Marching in a U.S. Army Infantry Brigade

    Science.gov (United States)

    2017-03-24

    DISTRIBUTION/AVAILABILITY STATEMENT TBD 13. SUPPLEMENTARY NOTES 14. ABSTRACT Road marching is an important physical training activity that prepares...to represent approximately equal response categories. Reported durations of unit PT activities were grouped by half hour. Because there were... Gender Male 732 10% n/a >0.99 Female 4 0% 1.00 Height (feet and inches) ≤5’8” 232 11% 1.36(0.74-2.51) 0.33 5’9”-5’11” 264 10% 1.17(0.64-2.16) 0.61

  3. Phytochemical screening of twelve species of phytoplankton isolated from Arabian Sea coast

    Institute of Scientific and Technical Information of China (English)

    Sushanth Vishwanath Rai; Madaiah Rajashekhar

    2015-01-01

    Objective:To analyze the phytochemicals in twelve species of marine phytoplankton. Methods: Total phenolic content of methanol extract was estimated by the Folin-Ciocalteu method. Total flavonoid content of the methanol extarct was determined by aluminium chloride method. Chlorophylls,β-carotene and astaxanthin were estimated by acetone extraction method. Vitamin C was determined by dinitrophenyl-hydrazine method. Phycobiliproteins such as allophycocyanin, phycocyanin and phycoerythrin in the aqueous extracts were determined. Results: Total phenolics varied from 5.41 mg gallic acid equivalents/g dry weight (DW) in Phormidium corium (P. corium) to 17.37 mg gallic acid equivalents/g DW inOscillatoria fremyii(O. fremyii). Total flavonoids ranged between 0.74 mg quercetin equivalent/g DW inP. corium and 9.87 mg quercetin equivalent/g DW inNannochloropsis oceanica. Chlorophyll-a pigment was high inChaetoceros calcitrans(C. calcitrans)(15.51 mg/g DW) and low inP. corium (1.08 mg/g DW). Chlorophyll-c ranged between 0.07 mg/g DW inNannochloropsis oceanica and 4.62 mg/g DW inC. calcitrans. High contents ofβ-carotene and astaxanthin were found inC. calcitrans and low inP. corium which ranged from 0.33 to 10.03 mg/g DW and 0.18 to 3.85 mg/g DW, respectively. Vitamin C content varied from 0.50 mg/g DW inC. calcitrans to 1.51 mg/g DW inPhormidium tenue.O. fremyii showed highest total phycobiliproteins of 317.05 mg/g DW. High contents of allophycocyanin and phycocyanin were found inO. fremyii, whereas high contents of phycoerythrin were found inOscillatoria sancta. All the three phycobiliproteins were low inChroococcus turgidus. Conclusions: Marine phytoplankton are one of the natural sources providing novel biologically active compounds with potential for pharmaceutical applications.

  4. Risk factors for chronic noncontiguous diseases: Twelve-week prospective study

    Directory of Open Access Journals (Sweden)

    Lapčević Mirjana

    2004-01-01

    basis of RF number and combination for genesis and development of CND in our sample, 74.7% of variability (development or risk may be accounted for angina pectoris (AP, 74.2% for DM+HTA, 70.0% for DM, 79.9% for HTA, 80.8% for myocardial infarction (Ml, and 85.8% of variability (development or risk for cerebrovascular insult (CVI. Twelve-week intervention resulted in reduction of HTA, HLP, glucose, and PC (p<0.001 levels as well as lower BMI and PA (p<0.5. To accomplish the aforementioned goals, continuous mutual activity of an individual, his/her family, health service and community is required, along with occasional evaluation of the obtained results.

  5. Experiencing a constructivist museum exhibit: A case study of twelve children and their families

    Science.gov (United States)

    Hill, Martha Anne Leech

    2002-04-01

    The American Association for the Advancement of Science and the National Research Council have called for the creation of a scientifically literate populace and introduced science standards and guidelines to direct this process. Science education in traditional school settings plays a key role in reaching this goal, but individuals over their lifetimes will have more exposure to science ideas through informal science experiences such as visits to museums and through diverse media sources. The purpose of this study was to explore the role museums play in this journey to science literacy. This qualitative collective case study examined the experience of 12 children and their families in a children's museum as they interacted with an exhibit designed along the tenets of constructivist theory to introduce children to ideas of science. Twelve children and their families were videotaped interacting with a model of a watershed that included the stream, surrounding land, gravel, and dam building and erosion abatement manipulatives. Children were interviewed to ascertain their stream-related ideas and conceptual understanding prior to and after using the exhibit. Parents completed demographic and post-exhibit experience questionnaires. Two museum staff members who played key roles in the development of the exhibit and surrounding gallery were also interviewed. Individual and cross-case analyses were done to describe the experience of each child and family, and to elucidate the commonalities of these experiences to describe the phenomenon of using a constructivist-based science exhibit. Results of the study indicate (1) the type of experience children and families had at the exhibit depended on child and parent interactions and roles each assumed, and (2) experience with the exhibit encouraged children to think more deeply about water topics, past experiences, and ideas they had previously constructed. Implications of this research include (1) parents should engage children

  6. [Risk factors for chronic noncontiguous diseases: twelve-week prospective study].

    Science.gov (United States)

    Lapcević, Mirjana; Vuković, Mira

    2004-01-01

    RF number and combination for genesis and development of CND in our sample, 74.7% of variability (development or risk) may be accounted for angina pectoris (AP), 74.2% for DM+HTA, 70.0% for DM, 79.9% for HTA, 80.8% for myocardial infarction (MI), and 85.8% of variability (development or risk) for cerebrovascular insult (CVI). Twelve-week intervention resulted in reduction of HTA, HLP, glucose, and PC (p<0.001) levels as well as lower BMI and PA (p<0.5). To accomplish the aforementioned goals, continuous mutual activity of an individual, his/her family, health service and community is required, along with occasional evaluation of the obtained results.

  7. Exercise-based cardiac rehabilitation in twelve European countries results of the European cardiac rehabilitation registry

    DEFF Research Database (Denmark)

    Benzer, Werner; Rauch, Bernhard; Schmid, Jean-Paul

    2017-01-01

    AIM: Results from EuroCaReD study should serve as a benchmark to improve guideline adherence and treatment quality of cardiac rehabilitation (CR) in Europe. METHODS AND RESULTS: Data from 2.054 CR patients in 12 European countries were derived from 69 centres. 76% were male. Indication for CR...... were under medication according to current guidelines for the treatment of CV risk factors. A wide range of CR programme designs was found (duration 3 to 24weeks; total number of sessions 30 to 196). Patient programme adherence after admission was high (85%). With reservations that eCRF follow-up data...

  8. GENDER DIFFERENCES IN SPORT INJURY RISK AND TYPES OF INJU-RIES: A RETROSPECTIVE TWELVE-MONTH STUDY ON CROSS-COUNTRY SKIERS, SWIMMERS, LONG-DISTANCE RUNNERS AND SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Leena Ristolainen

    2009-09-01

    Full Text Available This twelve months survey compared injury risk and injury types by genders (312 females, 262 males in 15- to 35-year-old cross-country skiers, swimmers, long- distance runners and soccer players. More male than female athletes reported at least one acute injury (44% vs. 35%, p < 0.05, and more male than female runners reported at least one overuse injury (69% vs. 51%, p < 0.05. When the incidence of acute and overuse injuries both separately and combined was calculated per 1000 training hours, per 1000 competition hours and all exposure hours combined we found no gender differences in either of these comparisons. After adjustment for sport event males were at increased risk for posterior thigh overuse injuries compared to females (relative risk (RR 5.8, 95% confidence interval (CI 1.3 to 26.4, p < 0.05 while females were at increased risk for overuse injuries in the ankle compared to males (RR 3.1, 95% CI 1.0 to 9.3, p < 0.05. After adjustment for exposure time (injuries/1000 exposure hours significance of the difference between the sexes in overuse injury to the ankle persisted (female 0.11 vs. male 0.02 injuries/1000 exposure hours, p < 0.05. Six athletes had an anterior cruciate ligament (ACL injury, of whom four were female soccer players. After combining all reported acute and overuse ankle and knee injuries, the proportion of athletes with such injury was higher in the female compared to male soccer players (75% and 54% respectively; p < 0.05, but no difference was found in such injuries when calculated per 1000 exposure hours. In conclusion, we found some gender differences in sport-related injuries, but most of these differences seemed to be explained at least in part by differences in the amount of training

  9. Male infertility microsurgical training

    Institute of Scientific and Technical Information of China (English)

    Akanksha Mehta; Philip S Li

    2013-01-01

    Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility.Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills.Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence,and reduces stress and operating time,benefiting both the patient and the surgeon.This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models.The role of emerging techniques,such as robotic-assisted microsurgery,is also discussed.

  10. The Impact of the Financial Crisis on the Content of Twelve Bestselling US Principles of Economics Textbooks

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    2013-01-01

    How have authors of twelve bestselling introductory US textbooks in economics responded to the traumatizing financial crisis? In general the financial crisis is described with a couple of lines here and there or it is dealt with in boxes, separate sections, or specific isolated chapters. Some...... of the textbooks distinguish themselves by also having made some modest qualitative changes of content as a reaction to the financial crisis (especially Colander 2010 and Krugman and Wells 2013). Applying my general analysis of the changes being made already in the twelve textbooks seen as a whole, I discuss how...... any introductory textbook could integrate the financial crisis more adequately into the general presentation, thereby hopefully contributing to enhancing the interest of the students....

  11. RUGBY GAME-RELATED STATISTICS THAT DISCRIMINATE BETWEEN WINNING AND LOSING TEAMS IN IRB AND SUPER TWELVE CLOSE GAMES

    Directory of Open Access Journals (Sweden)

    Luis Vaz

    2010-03-01

    Full Text Available The aim of the current study was to identify the Rugby game- related statistics that discriminated between winning and losing teams in IRB and S12 close games. Archival data reported to game-related statistics from 120 IRB games and 204 Super Twelve games played between 2003 and 2006. Afterwards, a cluster analysis was conducted to establish, according to game final score differences, three different match groups. Only the close games group was selected for further analysis (IRB n = 64 under 15 points difference and Super Twelve n = 95 under 11 points difference. An analysis to the structure coefficients (SC obtained through a discriminant analysis allowed to identify the most powerful game-related statistics in discriminating between winning and losing teams. The discriminant functions were statistically significant for Super Twelve games (Chi-square = 33.8, p < 0.01, but not for IRB games (Chi- square = 9.4, p = n.s.. In the first case, winners and losers were discriminated by possessions kicked (SC = 0.48, tackles made (SC = 0.45, rucks and pass (SC = -0.40, passes completed (SC = 0. 39, mauls won (SC = -0.36, turnovers won (SC = -0.33, kicks to touch (SC = 0.32 and errors made (SC = -0.32. The minus sign denotes higher values in losing teams. Rugby game-related statistics were able to discriminate between winners and losers in Super Twelve close games and suggest that a kicking based game supported by an effective defensive structure is more likely to win matches than a possession based one

  12. Radicular anatomy of twelve representatives of the Catasetinae subtribe (Orchidaceae: Cymbidieae

    Directory of Open Access Journals (Sweden)

    Cristiano Pedroso-de-Moraes

    2012-06-01

    Full Text Available Considering that the root structure of the Brazilian genera belonging to the Catasetinae subtribe is poorly known, we describe the roots of twelve representatives from this subtribe. For anatomical analysis, the roots were fixed in FAA 50, preserved in ethanol 70% and sectioned at its medium region using razor blades. The sections were stained with 0.05% astra blue and safranin and mounted in glycerin. For the identification of starch we used Lugol's solution; for lignin, floroglucin chloridric; for lipids, Sudan III, and for flavanoids, potassium hydroxide. The relevant aspects were registered using a digital camera joined with an Olympus microspope (BX51 model. The structural similarities of all roots support the placement of the subtribe Catasetinae into the monophyletic tribe Cymbidieae. Some root features are restricted to one or two taxa and can be useful in the systematics of the subtribe. For example, the occurrence of flavonoidic crystals characterizes the genera Catasetum and Cychnodes, and the number of the velamen layers and the shape of the epivelamen cells are useful to confirm the taxonomic position of Clowesia amazonica. The presence of velamen and flavonoidic crystals was interpreted as an adaptation to the epiphytic habit.Considerando que a estrutura das raízes de gêneros brasileiros pertencentes à subtribo Catasetinae é pouco conhecida, descrevemos as raízes de doze representantes desta subtribo. Para análise anatômica, as raízes foram fixadas em FAA 50, preservadas em álcool 70% e seccionadas na sua região média usando lâminas de barbear. Os cortes foram corados com astra blue e Safrablau 0,05% e montados em glicerina. Para a identificação do amido, utilizou-se a solução de Lugol; da lignina, floroglucina clorídrica, dos lipídios, Sudan III e dos flavonóides, hidróxido de potássio. Os aspectos relevantes foram registrados usando câmera digital acoplada a um microscópio Olympus (modelo BX51. As semelhan

  13. Lycopene and male infertility

    Institute of Scientific and Technical Information of China (English)

    Damayanthi Durairajanayagam; Ashok Agarwal; Chloe Ong; Pallavi Prashast

    2014-01-01

    Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inlficted on spermatozoa. It is postulated that lycopene may have other beneifcial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility-lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

  14. Male Reproductive System

    Science.gov (United States)

    ... designed to produce, nourish, and transport either the egg or sperm. Unlike the female, whose sex organs are located ... zygote and contains 46 chromosomes — half from the egg and half from the sperm. The genetic material from the male and female ...

  15. Lycopene and male infertility

    Directory of Open Access Journals (Sweden)

    Damayanthi Durairajanayagam

    2014-06-01

    Full Text Available Excessive amounts of reactive oxygen species (ROS cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inflicted on spermatozoa. It is postulated that lycopene may have other beneficial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility-lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

  16. A tortoiseshell male cat

    DEFF Research Database (Denmark)

    Pedersen, A. S.; Berg, Lise Charlotte; Almstrup, Kristian

    2014-01-01

    . Immunostaining using anti-vimentin and anti-VASA (DDX4) showed that only Sertoli cells and no germ cells were observed in the testicular tubules. As no sign of spermatogenesis was detected, we conclude that this is a classic case of a sterile, male tortoiseshell cat with a 39,XXY chromosome complement. © 2013 S...

  17. Male rat sexual behavior.

    Science.gov (United States)

    Agmo, A

    1997-05-01

    The male rat's sexual behavior constitutes a highly ordered sequence of motor acts involving both striate and smooth muscles. It is spontaneously displayed by most adult made rats in the presence of a sexually receptive female. Although the behavior is important for the survival of the species it is not necessary for survival of the individual. In that way it is different from other spontaneous behaviors such as eating, drinking, avoidance of pain, respiration or thermoregulation. Among other things, this means that it is difficult to talk about sexual deprivation or need. Nevertheless, studies of male sex behavior distinguish sexual motivation (the ease by which behavior is activated, "libido") from the execution of copulatory acts (performance, "potency") (Meisel, R.L. and Sachs, B.D., The physiology of male sexual behavior. In: E. Knobil and J.D. Neill (Eds.), The Physiology of Reproduction, 2nd Edn., Vol. 2, Raven Press, New York, 1994, pp. 3-105 [13]). The hormonal control of male sexual behavior has been extensively studied. It is clear that steroid hormones, androgens and estrogens, act within the central nervous system, modifying neuronal excitability. The exact mechanism by which these hormones activate sex behavior remains largely unknown. However, there exists a considerable amount of knowledge concerning the brain structures important for sexual motivation and for the execution of sex behavior. The modulatory role of some non-steroid hormones is partly known, as well as the consequences of manipulations of several neurotransmitter systems.

  18. Predictors of male microchimerism

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Mortensen, Laust Hvas; Andersen, Anne-Marie Nybo

    2012-01-01

    logistic regression and thereafter random forest modeling to evaluate the ability of a range of reproductive, lifestyle, hospital or clinic visit history, and other variables to predict whether women tested positive for male microchimerism. We found some indication that current use of contraceptive pills...

  19. Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males

    Institute of Scientific and Technical Information of China (English)

    J Patrik F(a)gerstam; Per A Whiss

    2006-01-01

    AIM: To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-ami-nosalicylic acid (5-ASA) medication or gender.METHODS: tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls.RESULTS: Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P< 0.05).CONCLUSION: Increased tP-selectin levels may alter the inflammatory response and susceptibility to throm-boembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies.

  20. Male Gender Role Dysfunction

    OpenAIRE

    Daig, Isolde

    2010-01-01

    Background: Men have a higher alcohol and cigarette consumption than women, they use more drugs, they have twice as high a suicide rate and only a minority of men attend on preventive medical checkups. Hypotheses: The central questions of the present study pertained to the identification of dysfunctional aspects of a male self concept and the possible correlations with risk behaviour of men in different age stages. One possible explanation for this high risk behaviour may be higher mascul...

  1. Adolescent male health.

    Science.gov (United States)

    Westwood, Michael; Pinzon, Jorge

    2008-01-01

    Although adolescent males have as many health issues and concerns as adolescent females, they are much less likely to be seen in a clinical setting. This is related to both individual factors and the health care system itself, which is not always encouraging and set up to provide comprehensive male health care. Working with adolescent boys involves gaining the knowledge and skills to address concerns such as puberty and sexuality, substance use, violence, risk-taking behaviours and mental health issues. The ability to engage the young male patient is critical, and the professional must be comfortable in initiating conversation about a wide array of topics with the teen boy, who may be reluctant to discuss his concerns. It is important to take every opportunity with adolescent boys to talk about issues beyond the presenting complain, and let them know about confidential care. The physician can educate teens about the importance of regular checkups, and that they are welcome to contact the physician if they are experiencing any concerns about their health or well-being. Parents of preadolescent and adolescent boys should be educated on the value of regular health maintenance visits for their sons beginning in their early teen years.

  2. Twelve cases of multiple myeloma in Nagasaki (especially seven atomic bombing casualty cases). [In Japanese

    Energy Technology Data Exchange (ETDEWEB)

    Ichimaru, M.; Yasuhi, S.; Ouchuru, S.

    1963-12-01

    Since 1958, there have been 12 cases of multiple myeloma in Nagasaki, and among them were 7 cases representing atomic bombing casualties, with 3 cases being with 2 km distance from the hypocenter. The age of onset was between 51 and 69 years, and the sex ratio was 8:4, it occurring mostly in males. Symptoms were predominantly low back pain and chest pain caused by the bone changes in 8 cases. Two cases complained of general malaise and palpitation which resulted from anemia. One developed persistent epistaris, and another complained of diplopia caused by the paralysis of the oculomotor nerve. Peripheral blood in all cases showed anemia, 9 with hyperchromic and 3 with normochromic or hypochromic anemia. Low platelet counts were seen in 3 cases. All showed leukopenia. All cases showed typical ..gamma..-globulin change with a myeloma peak, and in 4 cases showed an increase of ..beta..-globulin. Bence-Jones proteinuria was present in 5 cases. Average course was 1 year 4 months. Among complications, myeloma nephrosis, aplastic anemia, and pneumonia were the most important ones.

  3. EXERCISE LIMITATIONS IN A COMPETITIVE CYCLIST TWELVE MONTHS POST HEART TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    Nicolas G. Walton

    2009-12-01

    Full Text Available It has been well documented that for heart transplant recipients (HTrecipient post transplantation exercise capacity does not exceed 60% of healthy age-matched controls. Few studies have been undertaken to determine the cause of exercise limitations following heart transplantation (HT for an elite athlete. Participant was a 39 year old elite male cyclist who suffered an acute myocardial infarction after a cycling race and received a heart transplant (HT four months later. Six weeks prior to his AMI fitness testing was completed and a predicted VO2max of 58 mL·kg-1·min-1 and HRmax of 171 bpm was achieved. The participant underwent maximal exercise testing 6 and 12 months post transplant to determine exercise limitations. His results 6 and 12 months post transplant were a VO2max of 33.8 and 44.2 mL·kg-1·min-1 respectively, and a HR max that was 97% and 96% of HRmax measured. The participant showed an increase in both HRmax and VO2max 12 months post HT compared to previous testing. Results suggest that the limiting factors to exercise following HT are likely due to peripheral function, which became diminished as a result accumulated from 4 months of congestive heart failure, the strain of HT, and immunosuppressive therapy leading up to the exercise testing. Lifestyle before HT and a more aggressive approach to HT recovery should be considered necessary in the improvement of peripheral functioning following HT

  4. Twelve months follow-up after retrograde recanalization of superficial femoral artery chronic total occlusion

    Directory of Open Access Journals (Sweden)

    Joanna Wojtasik-Bakalarz

    2017-03-01

    Full Text Available Introduction : Fifty percent of cases of peripheral artery disease are caused by chronic total occlusion (CTO of the superficial femoral artery (SFA. Ten–fifteen percent of percutaneous SFA recanalization procedures are unsuccessful. In those cases the retrograde technique can increase the success rate of the procedure, but the long-term follow-up of such procedures is still unknown. Aim : To assess the efficacy and clinical outcomes during long-term follow-up after retrograde recanalization of the SFA. Material and methods: We included patients after at least one unsuccessful percutaneous antegrade recanalization of the SFA. Patients were evaluated for the procedural and clinical follow-up of mean time 13.9 months. Results: The study included 17 patients (7 females, 10 males who underwent percutaneous retrograde recanalization of the SFA from June 2011 to June 2015. The mean age of patients was 63 ±7 years. Retrograde puncture of the distal SFA was successful in all cases. A retrograde procedure was performed immediately after antegrade failure in 4 (23.5% patients and after a previously failed attempt in 13 (76.5% patients. The procedure was successful in 15 (88.2% patients, and unsuccessful in 2 (11.8% patients. Periprocedural complications included 1 peripheral distal embolization (successfully treated with aspiration thrombectomy, 1 bleeding event from the puncture site and 7 puncture site hematomas. During follow-up the all-cause mortality rate was 5.8% (1 patient, non-cardiac death. The primary patency rate at 12 months was 88.2% and secondary patency 100%. Conclusions : The retrograde SFA puncture seems to be a safe and successful technique for CTO recanalization and is associated with a low rate of perioperative and long-term follow-up complications.

  5. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans.

    Science.gov (United States)

    Steck, Susan E; Chalecki, Allison M; Miller, Paul; Conway, Jason; Austin, Gregory L; Hardin, James W; Albright, Craig D; Thuillier, Philippe

    2007-05-01

    Conjugated linoleic acid (CLA) alters body composition in animal models, but few studies have examined the effects of CLA supplementation on body composition and clinical safety measures in obese humans. In the present study, we performed a randomized, double-blind, placebo-controlled trial to examine the changes in body composition and clinical laboratory values following CLA (50:50 ratio of cis-9, trans-11 and trans-10, cis-12 isomers) supplementation for 12 wk in otherwise healthy obese humans. Forty-eight participants (13 males and 35 females) were randomized to receive placebo (8 g safflower oil/d), 3.2 g/d CLA, or 6.4 g/d CLA for 12 wk. Changes in body fat mass and lean body mass were determined by dual-energy X-ray absorptiometry. Resting energy expenditure was assessed by indirect calorimetry. Clinical laboratory values and adverse-event reporting were used to monitor safety. Lean body mass increased by 0.64 kg in the 6.4 g/d CLA group (P < 0.05) after 12 wk of intervention. Significant decreases in serum HDL-cholesterol and sodium, hemoglobin, and hematocrit, and significant increases in serum alkaline phosphatase, C-reactive protein, and IL-6, and white blood cells occurred in the 6.4 g/d CLA group, although all values remained within normal limits. The intervention was well tolerated and no severe adverse events were reported, although mild gastrointestinal adverse events were reported in all treatment groups. In conclusion, whereas CLA may increase lean body mass in obese humans, it may also increase markers of inflammation in the short term.

  6. Exercise limitations in a competitive cyclist twelve months post heart transplantation.

    Science.gov (United States)

    Patterson, Jeremy A; Walton, Nicolas G

    2009-01-01

    It has been well documented that for heart transplant recipients (HTrecipient) post transplantation exercise capacity does not exceed 60% of healthy age-matched controls. Few studies have been undertaken to determine the cause of exercise limitations following heart transplantation (HT) for an elite athlete. Participant was a 39 year old elite male cyclist who suffered an acute myocardial infarction after a cycling race and received a heart transplant (HT) four months later. Six weeks prior to his AMI fitness testing was completed and a predicted VO2max of 58 mL·kg(-1)·min(-1) and HRmax of 171 bpm was achieved. The participant underwent maximal exercise testing 6 and 12 months post transplant to determine exercise limitations. His results 6 and 12 months post transplant were a VO2max of 33.8 and 44.2 mL·kg(-1)·min(-1) respectively, and a HR max that was 97% and 96% of HRmax measured. The participant showed an increase in both HRmax and VO2max 12 months post HT compared to previous testing. Results suggest that the limiting factors to exercise following HT are likely due to peripheral function, which became diminished as a result accumulated from 4 months of congestive heart failure, the strain of HT, and immunosuppressive therapy leading up to the exercise testing. Lifestyle before HT and a more aggressive approach to HT recovery should be considered necessary in the improvement of peripheral functioning following HT. Key pointsPhysical work capacity following heart transplantation is not limited by cardiac denervation.Heart transplant rehabilitation should focus efforts on endothelial and muscular limitations.

  7. Retention and Effectiveness of Dental Sealant After Twelve Months in Iranian Children

    Directory of Open Access Journals (Sweden)

    Rafatjou

    2013-12-01

    Full Text Available Background Pit-and-fissure sealants are safe and effective ways to prevent dental caries and are considered as a part of an overall caries-preventive strategy. Dental caries are a public health problem and the most common intraoral disease affecting mankind. It is an infectious transmissible disease, with the child patient being at the highest risk. Objectives The purpose of this study was to evaluate the retention rates and effectiveness of occlusal sealants in children in Hamadan, Iran. Materials and Methods A total of 118 sealed first permanent molar teeth in 52 students (mean age, 8 years;male, 48% were evaluated for fissure sealant retention and occlusal caries status. All teeth were examined 12 months after application of sealants. Data were collected and evaluated by survival analyses methods for age at placement, patient sex, decayed/missing/filled teeth (DMFT index, fluoride history, toothbrush, tooth position in arch, and refer to dentistry. Results The overall success rate with pit-and-fissure sealant was 68.6%; in addition, 38.9% of the seals were completely retained, 38.9% partially lost, and 10.2% completely lost. There were no signs of carious lesions in 69.6% of the teeth. The factors associated with an increased risk of failure included female sex (P = 0.001 and no history of fluoride use (P < 0.01. There were no significant association between the results and patient age, tooth position in the arch, DMFT index, toothbrush, and refer to dentistry. Conclusions Although pit-and-fissure sealants are effective methods for preventing tooth caries, the low success rate of fissure sealants in current study indicated that dental sealant need to be implemented more carefully and follow-up programs are advisable.

  8. Twelve-month follow-up of left atrial appendage occlusion with Amplatzer Amulet.

    Science.gov (United States)

    Kleinecke, Caroline; Park, Jai-Wun; Gödde, Martin; Zintl, Konstantin; Schnupp, Steffen; Brachmann, Johannes

    2017-01-01

    The Amplatzer Amulet (St. Jude Medical, Minneapolis, MN, USA) is a second gen-eration Amplatzer device for left atrial appendage (LAA) occlusion (LAAO) for stroke prophylaxis in patients with atrial fibrillation. This research sought to assess the clinical performance of the Amplatzer Amulet device and in follow up for 12 months. In this single-center registry patients with atrial fibrillation and contraindication to oral anticoagulation underwent LAAO with the Amplatzer Amulet device. Follow-up was performed before discharge, by transesophageal echocardiography (TEE) after 6 weeks and telephone interview after 3, 6 and 12 months. Between October 2014 and August 2015 50 patients (76.1 ± 8.3 years; 30 male) were en-rolled. Procedural success was achieved in 49 (98%) patients. Major periprocedural adverse events were observed in 4 (8%) of patients: 1 device embolization, 2 pericardial effusions requiring pericardiocente-sis and 1 prolonged hospital stay due to retropharyngeal hematoma from the TEE probe. Follow-up TEE was available in 38 of 50 patients showing complete LAA sealing in all. 2 device-related thrombi were also documented. At 12-month follow-up 7 patients had died unrelated to the device. Ischemic stroke occurred in 3 patients. According to neurological examination two were classified as microangiopathic and not cardio-embolic. The other one could not be classified. Bleeding complications (5 minor, 3 major) were documented in 8 patients. Although minimizing procedure-related complications remains challenging, LAAO with the Amplatzer Amulet device showed high procedural success and excellent LAA sealing. (Cardiol J 2017; 24, 2: 131-138).

  9. Ocular hypotensive effect, preservation of visual fields, and safety of adding dorzolamide to prostaglandin therapy for twelve months

    Directory of Open Access Journals (Sweden)

    Kenji Inoue

    2011-03-01

    Full Text Available Kenji Inoue1,3, Mieko Masumoto1,3, Masato Wakakura1, Goji Tomita2, On behalf of the Ochanomizu Ophthalmology Study Group31Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan; 3Ochanomizu Ophthalmology, Tokyo, JapanPurpose: To prospectively evaluate the safety, hypotensive effect, and preservation of visual fields of dorzolamide when added to latanoprost.Subjects and methods: This study included 46 patients (46 eyes with primary open-angle glaucoma who had been treated with latanoprost. Dorzolamide (1% was added to latanoprost, and the intraocular pressure (IOP was monitored before and after 3, 6, and 12 months. The mean deviation shown by Humphrey perimetry was compared before and after twelve months of treatment. Adverse reactions were monitored over the 12-month study period.Results: The mean baseline IOP was 17.2 ± 3.0 mmHg while those after 3, 6 and 12 months of treatment were 14.9 ± 3.0 mmHg, 14.5 ± 3.2 mmHg, and 14.6 ± 2.6 mmHg respectively (P < 0.0001, 1-ß(power = 0.9999571. The absolute reduction of IOP and the percent reduction were similar after 3, 6, and 12 months of treatment. The mean deviation on Humphrey perimetry was similar before and after twelve months of treatment. Three patients discontinued dorzolamide therapy due to elevation of IOP and one patient discontinued it because of adverse reactions.Conclusion: Dorzolamide is safe and effective when used for twelve months as add-on therapy to latanoprost for open-angle glaucoma.Keywords: dorzolamide, primary open-angle glaucoma, latanoprost 

  10. Do supervised weekly exercise programs maintain functional exercise capacity and quality of life, twelve months after pulmonary rehabilitation in COPD?

    Directory of Open Access Journals (Sweden)

    Alison Jennifer A

    2007-05-01

    Full Text Available Abstract Background Pulmonary rehabilitation programs have been shown to increase functional exercise capacity and quality of life in COPD patients. However, following the completion of pulmonary rehabilitation the benefits begin to decline unless the program is of longer duration or ongoing maintenance exercise is followed. Therefore, the aim of this study is to determine if supervised, weekly, hospital-based exercise compared to home exercise will maintain the benefits gained from an eight-week pulmonary rehabilitation program in COPD subjects to twelve months. Methods Following completion of an eight-week pulmonary rehabilitation program, COPD subjects will be recruited and randomised (using concealed allocation in numbered envelopes into either the maintenance exercise group (supervised, weekly, hospital-based exercise or the control group (unsupervised home exercise and followed for twelve months. Measurements will be taken at baseline (post an eight-week pulmonary rehabilitation program, three, six and twelve months. The exercise measurements will include two six-minute walk tests, two incremental shuttle walk tests, and two endurance shuttle walk tests. Oxygen saturation, heart rate and dyspnoea will be monitored during all these tests. Quality of life will be measured using the St George's Respiratory Questionnaire and the Hospital Anxiety and Depression Scale. Participants will be excluded if they require supplemental oxygen or have neurological or musculoskeletal co-morbidities that will prevent them from exercising independently. Discussion Pulmonary rehabilitation plays an important part in the management of COPD and the results from this study will help determine if supervised, weekly, hospital-based exercise can successfully maintain functional exercise capacity and quality of life following an eight-week pulmonary rehabilitation program in COPD subjects in Australia.

  11. The myrmicine ant genus Metapone Forel (Hymenoptera: Formicidae): a global taxonomic review with descriptions of twelve new species.

    Science.gov (United States)

    Taylor, Robert W; Alpert, Gary D

    2016-04-26

    The 28 known species of Metapone are monographed and illustrated. Twelve are described as new: M. africana, Gabon; M. balinensis, Bali, Indonesia; M. enigmatica, northeast New Guinea; M. hoelldobleri, northeast Queensland, Australia; M. javana, Java, Indonesia; M. manni, Viti Levu, Fiji; M. mathinnae, Flinders Island, Tasmania, Australia; M. philwardi, northeast New Guinea; M. salomonis, Guadalcanal, Solomon Islands; M. tecklini, northeast Queensland; M. titan, New Ireland, Papua New Guinea; M. wallaceana, Lombok, Indonesia; spp.n. New synonymies include M. greeni Forel = M. johni Karavaiev (Sri Lanka) syn.n, and M. jacobsoni Crawley (Sumatra) = M. nicobarensis Tiwari & Jonathan (Great Nicobar Island) syn.n.

  12. 谐振致装甲步兵椎间盘源性下腰痛的调查与分析%The epidemiological investigation and analysis of intervertebral disk-derived low back pain caused by syntony in armored infantry

    Institute of Scientific and Technical Information of China (English)

    刘维高; 黄昌林

    2015-01-01

    Objective To investigate the incidence of intervertebral disk-derived low back pain caused by long-last syntony situation among armored infantry and the improvement of low back muscle after relative strength exercise. Methods With the forms and the diagnostic standard of intervertebral disk-derived low back pain , authors conducted a investigation of 402 armored infantry in long-last syntony situation and compared the incidence of intervertebral disk-derived low back pain and the degree of pain. By teaching relative strength exercise of low back muscle,authors expected to improve the severity of their low back pain. Results There were 37 cases of intervertebral disk-derived low back pain patients among the 402 armored infantry accounted for 9.2%. Among them,27 were the staff working on vehicles with accounted for 73.0% and 10 were the carried passengers with accounted for 27.0%. And there was significant difference between both (P0.05).Ⅰ度疼痛共发生25例,Ⅱ度疼痛发生12例,Ⅰ度疼痛明显高于Ⅱ度疼痛(P<0.05).通过8周的腰背肌锻炼后,载员的有效率明显高于乘员(P<0.05);锻炼前与锻炼后比较,有显著性差异(P<0.05).结论 某部装甲步兵椎间盘源性下腰痛发生率较高,乘员发生率高于载员,≥2年军龄发生率最高,疼痛程度多为Ⅰ、Ⅱ度,通过适当的腰背肌相对肌力训练,对Ⅰ、Ⅱ度疼痛的缓解有效,可作为治疗并预防Ⅰ、Ⅱ度椎间盘源性下腰痛患者的常规措施.

  13. Advanced Procedures in Male Incontinence: The Male Sling

    Medline Plus

    Full Text Available Advanced Procedures in Male Incontinence: The Virtue® Male Sling Click Here to view the BroadcastMed, Inc. Privacy Policy and Legal Notice © 2017 BroadcastMed, Inc. All rights reserved.

  14. Advanced Procedures in Male Incontinence: The Male Sling

    Medline Plus

    Full Text Available Advanced Procedures in Male Incontinence: The Virtue® Male Sling Click Here to view the BroadcastMed, Inc. Privacy Policy and Legal Notice © 2017 BroadcastMed, Inc. All rights reserved.

  15. Projection of male fantasies

    DEFF Research Database (Denmark)

    Bonde, Hans

    2013-01-01

    -war period. Advocates of women's athletics interpreted competitive sports as perfect tools for women's conquest of male territory, whereas supporters of female gymnastics considered athletics to be an antidote to the health-promoting and graceful essence of femininity. Agnete Bertram was one of Lindhard......-1949) laid the foundation for the birth of exercise physiology in Scandinavia. In addition to his basic-level studies of physiology, Lindhard also became deeply involved in developing a theory of gymnastics that would bring a wide range of Danish gymnastics traditions onto a surer theoretical footing...

  16. [Urethrocele in males].

    Science.gov (United States)

    el Mrini, M; Bennani, S; Aboutaieb, R; Joual, A; Benjelloun, S

    1993-01-01

    Concerning one case of male urethral diverticulum, the characteristics of this rare affection are reviewed. Carriage for long time of urethral catheter and urethroplasty are the more frequent etiologies of this affection. The diagnosis is clinic, based on the discovery of tumefaction on the urethral track which pression makes spring up urine through urethral meatus. The urethrography confirms the diagnosis. Surgical approach consists on the resection of the diverticulum and urethrorrhaphy in one or two stages, based on diverticular neck size and sheet quality.

  17. Trenbolone acetate induced changes in the genital tract of male pigs.

    Science.gov (United States)

    López-Bote, C; Sancho, G; Martínez, M; Ventanas, J; Gázquez, A; Roncero, V

    1994-03-01

    Eleven entire and twelve castrated male pigs were implanted with trenbolone acetate and the effects of the treatment on genital tract macro- and microscopical modifications were evaluated and compared to non-implanted animals. In entire male pigs a reduction of testicular weight and size was observed as a consequence of the treatment (< 0.001), but no important modifications were found in bulbourethral gland and seminal vesicles macroscopically. Castrated non-implanted males had bulbourethral gland atrophy (P < 0.01), while castrated implanted ones showed similar development to entire males. As for vesicular glands there were no significant differences among the four groups under study. Histological study of prostate has demonstrated structural modifications. As a consequence of the treatment glandular lumen was increased (P < 0.05), and most parenchyma was occupied by polymorphous cysts.

  18. [Prolactin and male fertility].

    Science.gov (United States)

    Schreiber, G; Börner, A; Lauterbach, H; Thiel, W

    1983-03-01

    On 68 selected patients with disturbances of the potentia generandi et/sive coeundi (25 males with healthy metabolism and 43 males with diabetes) as well as 14 control persons PRL, LH, FSH, testosterone and oestradiol were determined radioimmunologically and the results were ascribed to sexological, clinical, spermatological and testo-histological findings. A statistically secure correlation was found between PRL values and disturbance of the libido as well as the presence of a gynaecomasty. PRL did not correlate with the spermatological variables volume of ejaculate, relative and absolute number of spermatozoa and motility. PRL did also not correlate with the testohistological findings. A relation between PRL and the peptide hormones LH and FSH as well as the steroid hormones testosterone and oestradiol could not be ascertained. Therefore the diagnostic values of a PRL determination is much limited; the pertinency of a hyperprolactinaemia may be increased by the proof of the symptoms reduction of libido and gynaecomasty with simultaneous disturbance of fertility. In our opinion the definition of hyperprolactinaemia needs revision, since at only determination of the basal value of more than 800 mU/l no more frequently pathologically andrological findings are to be observed than below 200 mU/l.

  19. Experiencing Male Infertility

    Directory of Open Access Journals (Sweden)

    Esmée Hanna

    2015-10-01

    Full Text Available This article examines the qualitative research literature that exists in relation to men’s experiences of male infertility. Since men have often been marginalized in the realm of reproduction, including academic research on infertility, it is important to focus on any qualitative research that gives voices to male perspectives and concerns. Given the distress documented by studies of infertile women, we focus in particular on the emotive responses and lived experiences of men in relation to infertility. In this article then, we present an analysis of the core themes across 19 qualitative articles, which include “infertility as crisis”; “emoting infertility- men as “being strong”’ “infertility as a source of stigma”; and the “desire for fatherhood.” In light of these insights, we identify key areas for future research and development including men’s emotional responses to infertility, how men seek support for infertility, the intersection between masculinity and infertility, the relationship between the desire to father and infertility, and the outcomes of infertility for men in terms of other aspects of their lives. We suggest that such research would facilitate making the experiences of men more central within our understandings of infertility within a field that has primarily been female focused.

  20. [Orchitis and male infertility].

    Science.gov (United States)

    Schuppe, H-C; Pilatz, A; Hossain, H; Meinhardt, A; Bergmann, M; Haidl, G; Weidner, W

    2010-05-01

    Infections and inflammations of the genital tract are considered the most frequent causes of reduced male fertility, but conclusive epidemiological data are not available. In view of the exposure of germ cells to pathogenic components as well as the cells and mediators involved in the inflammatory processes, irreversible damage to spermatogenesis and corresponding decline of ejaculate quality are to be expected, particularly in cases of chronic orchitis. While the consequences of orchitis and epididymo-orchitis that exhibit clinical symptoms due to systemic or local infections are well known, including testicular atrophy and complete loss of fertility, those cases of inflammatory reactions of the testicles that manifest an asymptomatic or subclinical course, or are not even due to an infection, have received little attention until now. However, systematic histopathological analyses have shown a high prevalence of asymptomatic inflammatory reactions in testicular biopsies from infertile men. The mostly focal lymphocytic infiltrates correlate with the degree of damage to spermatogenesis and corresponding clinical and endocrinological parameters of testicular function. Noninvasive diagnostic techniques are not yet available so that chronic asymptomatic inflammations of the testicles as the primary cause or cofactor of male fertility disorders are underestimated. Except for administration of pathogen-specific antibiotics, treatment recommendations are to a large extent still lacking.

  1. Lisping and male homosexuality.

    Science.gov (United States)

    Van Borsel, John; Van de Putte, Anneleen

    2014-08-01

    The present study examined the popular stereotype that gay men lisp by evaluating to what extent listeners associated dental or frontal articulation/lisping with gayness. Fifteen heterosexual males and 15 heterosexual females listened to 275 samples of read speech and judged the sexual orientation of the speakers. A total of 175 of the samples were of homosexual men, 74 (42.3 %) of which had been identified with lisping in a previous study; 100 were of heterosexual men, 18 (18 %) of which had been identified with lisping previously. Based on the ratings of the listeners of the present study, lisping speakers were significantly more often judged to be homosexual. This was true for the group as a whole as well as for the subgroup of homosexual and heterosexual men separately. Furthermore, there was no significant gender difference with respect to associating lisping with gayness. Male and female judges associated lisping with gayness to a similar degree. Additional analysis showed that overall 56.2 % of the time the judges were correct in their judgment of the speakers' sexual orientation. The results of this study confirmed previous preliminary findings that suggested that frontal or dental articulation/lisping is a feature that listeners associate with gayness. The reason for this association remains to be clarified.

  2. Blood Pressure, Sleep Quality and Fatigue in Shift Working Police Officers: Effects of a Twelve Hour Roster System on Cardiovascular and Sleep Health

    Directory of Open Access Journals (Sweden)

    Jaymen L. Elliott

    2016-01-01

    Full Text Available Background: Police officers have been reported to exhibit a high incidence of pathologies, which present prematurely in an otherwise healthy population. Shift work has also been associated with an increased risk of cardiovascular and sleep disorders, attributable to its propensity for circadian rhythm dysfunction. However, contention exists as to whether shift work has a direct effect upon blood pressure (BP regulation. Methods: This cross-sectional study sought to determine changes in BP and associations with the overall sleep quality and fatigue in 206 general duties police officers (n = 140 males of the New South Wales Police Force in Australia. The subjects’ BP was assessed before and after their twelve hour shift, during which time they also completed the Lifestyle Appraisal Questionnaire, Pittsburgh Sleep Quality Index (PSQI, Epworth Sleepiness Scale and Fatigue Severity Scale (FSS. Results: Poor sleep quality (PSQI and fatigue severity (FSS were found to predominate in the sample (69% and 51% respectively. Although there was no change in BP for male participants, female officers’ systolic blood pressure (SBP was found to increase significantly across the shift (p < 0.001, but with no change found in females’ diastolic blood pressure (DBP. Finally, higher pre and post-shift SBP (r = −0.26, p = 0.001; r = −0.25, p = 0.001, respectively and DBP (r = −0.26, p = 0.001; r = −0.26, p = 0.001, respectively were significantly correlated with lower FSS scores after accounting for age, waist-hip ratio and lifestyle risk factors. Conclusions: Based on these preliminary findings, there was a significant increase in SBP of female police officers after shift work, while BP and fatigue levels in all police officers were strongly related. Moreover, the predominating poor sleep quality and impact of fatigue in this sample remain a concern. Further research is required to ensure the physiological welfare of police officers, while strategies

  3. Knee kinematics and kinetics in former soccer players with a 16-year-old ACL injury – the effects of twelve weeks of knee-specific training

    Directory of Open Access Journals (Sweden)

    Holmström Eva

    2007-04-01

    Full Text Available Abstract Background Training of neuromuscular control has become increasingly important and plays a major role in rehabilitation of subjects with an injury to the anterior cruciate ligament (ACL. Little is known, however, of the influence of this training on knee stiffness during loading. Increased knee stiffness occurs as a loading strategy of ACL-injured subjects and is associated with increased joint contact forces. Increased or altered joint loads contribute to the development of osteoarthritis. The aim of the study was to determine if knee stiffness, defined by changes in knee kinetics and kinematics of gait, step activity and cross-over hop could be reduced through a knee-specific 12-week training programme. Methods A 3-dimensional motion analysis system (VICON and a force plate (AMTI were used to calculate knee kinetics and kinematics before and after 12 weeks of knee-specific training in 12 males recruited from a cohort with ACL injury 16 years earlier. Twelve uninjured males matched for age, sex, BMI and activity level served as a reference group. Self-reported patient-relevant data were obtained by the KOOS questionnaire. Results There were no significant changes in knee stiffness during gait and step activity after training. For the cross-over hop, increased peak knee flexion during landing (from 44 to 48 degrees, p = 0.031 and increased internal knee extensor moment (1.28 to 1.55 Nm/kg, p = 0.017 were seen after training, indicating reduced knee stiffness. The KOOS sport and recreation score improved from 70 to 77 (p = 0.005 and was significantly correlated with the changes in knee flexion during landing for the cross-over hop (r = 0.6, p = 0.039. Conclusion Knee-specific training improved lower extremity kinetics and kinematics, indicating reduced knee stiffness during demanding hop activity. Self-reported sport and recreational function correlated positively with the biomechanical changes supporting a clinical importance of the

  4. The Effect o f Twelve - Week Recreation Act i v ities on the Anxiety Level of Female Pri soners

    Directory of Open Access Journals (Sweden)

    Zekiye B AŞARAN

    2015-07-01

    Full Text Available T h e a i m o f t h e s t u d y w a s to examine the effect of twelve - weeks recreation activities on the trait anxiety level of female prisoners in the prisons. The sampling of this study consists of 45 female prisoners who are in the Open Prison in Kandira, 22 of whom are in the experimental group and 23 of whom are in the control group. Different activities, such as music, dance, meditatio n, sportive activities, movies and videos, fun and entertainment activities and competitions, were performed one and half hours a day and two days a week. This lasted for twelve weeks. The data were collected by pre - tests and post - tests that were given bo th at the beginning and at the end of this program. Personal information form and Spielberger anxiety inventory were used as the data collecting tool. The reliability coefficient (Cronbach Alpha was calculated as ,873. The data were analysed with SPSS Win dows 18 programme. Descriptive statistics and Wilcoxon test were conducted. A si gnificant statistical correlation was determined between the prisoners’ pre - tests and post - tests scores in the experimental group (p <0.05. A s c o n c l u s i o n , a positive impact on trait anxiety levels of prisoners w a s f o u n d a f t e r 12 weeks o f recreational activities.

  5. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-04-06

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve.

  6. Twelve new species and fifty-three new provincial distribution records of Aleocharinae rove beetles of Saskatchewan, Canada (Coleoptera, Staphylinidae).

    Science.gov (United States)

    Klimaszewski, Jan; Larson, David J; Labrecque, Myriam; Bourdon, Caroline

    2016-01-01

    One hundred twenty species of aleocharine beetles (Staphylinidae) are recognized in the province of Saskatchewan. Sixty-five new provincial records, including twelve new species and one new North American record, are presented. Oligota inflata (Mannerheim), a Palearctic species, is newly recorded for North America. The following twelve species are described as new to science: Acrotona pseudopygmaea Klimaszewski & Larson, sp. n., Agaricomorpha pulchra Klimaszewski & Larson, sp. n. (new genus record for Canadian fauna), Aleochara elisabethae Klimaszewski & Larson, sp. n., Atheta (Dimetrota) larsonae Klimaszewski & Larson, sp. n., Atheta (Microdota) pseudopittionii Klimaszewski & Larson, sp. n., Atheta (Microdota) spermathecorum Klimaszewski & Larson, sp. n., Atheta (sensu lato) richardsoni Klimaszewski & Larson, sp. n., Brachyusa saskatchewanae Klimaszewski & Larson, sp. n., Dochmonota langori Klimaszewski & Larson, sp. n., Dochmonota simulans Klimaszewski & Larson, sp. n., Dochmonota websteri Klimaszewski & Larson, sp. n., and Oxypoda domestica Klimaszewski & Larson, sp. n. Colour images of habitus and black and white images of the median lobe of the aedeagus, spermatheca, and tergite and sternite VIII are presented for all new species, Oligota inflata Mannerheim and Dochmonota rudiventris (Eppelsheim). A new synonymy is established: Tetralina filitarsus Casey, syn. n. = Tetralina helenae Casey, now placed in the genus Brachyusa Mulsant & Rey.

  7. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-04-06

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve.

  8. Occupational causes of male infertility

    DEFF Research Database (Denmark)

    Bonde, Jens P E

    2013-01-01

    To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function.......To highlight and discuss the new evidence on occupational and environmental risk to male reproductive function....

  9. Bilateral synchronous male breast cancer

    National Research Council Canada - National Science Library

    Nwashilli, Nnamdi J; Ugiagbe, Ezekiel E

    2015-01-01

    .... The importance of this case report is to create more awareness that breast cancer can occur in males just as in females, though the incidence is rare in males. Early presentation and compliance with treatment modality provide a better outcome.

  10. A class III archaeological survey of twelve region wide fencing upgrade locations in Eagle, Grand, Gunnison, Jackson, Moffat, Pitkin, and Routt counties, Colorado

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Colorado Department of Transportation proposes to upgrade existing right-of-way fencing along roadways at twelve separate locations in northwestern Colorado. To...

  11. Male-male pheromone signalling in a lekking Drosophila.

    Science.gov (United States)

    Widemo, Fredrik; Johansson, Björn G

    2006-03-22

    Interest in sex pheromones has mainly been focused on mate finding, while relatively little attention has been given to the role of sex pheromones in mate choice and almost none to competition over mates. Here, we study male response to male pheromones in the lekking Drosophila grimshawi, where males deposit long-lasting pheromone streaks that attract males and females to the leks and influence mate assessment. We used two stocks of flies and both stocks adjusted their pheromone depositing behaviour in response to experimental manipulation, strongly indicating male ability to distinguish between competitors from qualitative differences in pheromone streaks alone. This is the first example of an insect distinguishing between individual odour signatures. Pheromone signalling influenced competition over mates, as males adjusted their investment in pheromone deposition in response to foreign pheromone streaks. Both sexes adapt their behaviour according to information from olfactory cues in D. grimshawi, but the relative benefits from male-female, as compared to male-male signalling, remain unknown. It seems likely that the pheromone signalling system originally evolved for attracting females to leks. The transition to a signalling system for conveying information about individuals may well, however, at least in part have been driven by benefits from male-male signalling.

  12. The Extension of The Twelve-Point Sphere Theorem for a Tetrahedron%四面体的十二点二次曲面

    Institute of Scientific and Technical Information of China (English)

    王奇志; 王东生

    2012-01-01

    垂心四面体中四条高的垂足,四个面的重心及从各顶点与四面体的垂心连线的三等分点,共十二个点共球.试图把垂心改为四面体内的任意点,相应地把四条高线改换为过该点与每个顶点连线的共点直线组时,则将把垂心四面体的十二点球有趣地推广为四面体的十二点二次曲面.%The four feet of four altitudes for an orthocenter tetrahedron, the centers of gravity of the four faces, the trisection of the line segments from the orthocenter to four summits, total twelve points lie on same sphere, which is known as twelve-point sphere. If the orthocenter can be changed into any point within a tetrahedron in this paper, and corresponding the four perpendiculars also can be changed into the four lines segment passing through the given point to the summits of the tetrahedron, the twelve-point sphere can be changed into twelve-point quadric surface. Twelve point sphere of an orthocenter tetrahedron can be generalized to the twelve-point quadratic surface of a tetrahedron.

  13. Specific cerebral activation due to visual erotic stimuli in male-to-female transsexuals compared with male and female controls: an fMRI study.

    Science.gov (United States)

    Gizewski, Elke R; Krause, Eva; Schlamann, Marc; Happich, Friederike; Ladd, Mark E; Forsting, Michael; Senf, Wolfgang

    2009-02-01

    Transsexuals harbor the strong feeling of having been born to the wrong sex. There is a continuing controversial discussion of whether or not transsexualism has a biological representation. Differences between males and females in terms of functional imaging during erotic stimuli have been previously described, revealing gender-specific results. Therefore, we postulated that male-to-female (MTF) transsexuals may show specific cerebral activation differing from their biological gender. Cerebral activation patterns during viewing of erotic film excerpts in functional magnetic resonance imaging (fMRI). Twelve male and 12 female heterosexual volunteers and 12 MTF transsexuals before any treatment viewed erotic film excerpts during fMRI. Additionally, subjective rating of sexual arousal was assessed. Statistics were performed using the Statistical Parametric Mapping software. Significantly enhanced activation for men compared with women was revealed in brain areas involved in erotic processing, i.e., the thalamus, the amygdala, and the orbitofrontal and insular cortex, whereas no specific activation for women was found. When comparing MTF transsexuals with male volunteers, activation patterns similar to female volunteers being compared with male volunteers were revealed. Sexual arousal was assessed using standard rating scales and did not differ significantly for the three groups. We revealed a cerebral activation pattern in MTF transsexuals compared with male controls similar to female controls compared with male controls during viewing of erotic stimuli, indicating a tendency of female-like cerebral processing in transsexualism.

  14. Plasma boron and the effects of boron supplementation in males.

    Science.gov (United States)

    Green, N R; Ferrando, A A

    1994-11-01

    Recently, a proliferation of athletic supplements has been marketed touting boron as an ergogenic aid capable of increasing testosterone. The effect of boron supplementation was investigated in male bodybuilders. Ten male bodybuilders (aged 20 to 26) were given a 2.5-mg boron supplement, while nine male bodybuilders (aged 21 to 27) were given a placebo for 7 weeks. Plasma total and free testosterone, plasma boron, lean body mass, and strength measurements were determined on day 1 and day 49 of the study. A microwave digestion procedure followed by inductively coupled argon plasma spectroscopy was used for boron determination. Twelve subjects had boron values at or above the detection limit with median value of 25 ng/ml (16 ng/ml lower quartile and 33 ng/ml upper quartile). Of the ten subjects receiving boron supplements, six had an increase in their plasma boron. Analysis of variance indicated no significant effect of boron supplementation on any of the other dependent variables. Both groups demonstrated significant increases in total testosterone (p bodybuilding can increase total testosterone, lean body mass, and strength in lesser-trained bodybuilders, but boron supplementation affects these variables not at all.

  15. Twelve reasons to refuse the nuclear in the MDP; Douze raisons pour refuser le nucleaire dans le MDP

    Energy Technology Data Exchange (ETDEWEB)

    Bonduelle, A

    2000-07-01

    The author presents twelve reasons which show that the nuclear energy has not a place in the MDP Mechanism of Clean Development: a main loophole for the developed countries, the doubtful ''additionality'' of the nuclear, the treaty ratification is more difficult with the nuclear, the domestic energy conservation is more efficient in Europe than the nuclear development, the nuclear white elephants facing the South debts, the technology transfers are doubtful, the developing countries and the sustainable development policies are evicted from the MDP, some options are more powerful in the South, the reactors and transport networks size are unsuited, the absence of democratic control, the nuclear proliferation, the nuclear safety and the wastes. (A.L.B.)

  16. Twelve positions in a β-lactamase that can expand its substrate spectrum with a single amino acid substitution.

    Directory of Open Access Journals (Sweden)

    Hyojeong Yi

    Full Text Available The continuous evolution of β-lactamases resulting in bacterial resistance to β-lactam antibiotics is a major concern in public health, and yet the underlying molecular basis or the pattern of such evolution is largely unknown. We investigated the mechanics of the substrate fspectrum expansion of the class A β-lactamase using PenA of Burkholderia thailandensis as a model. By analyzing 516 mutated enzymes that acquired the ceftazidime-hydrolyzing activity, we found twelve positions with single amino acid substitutions (altogether twenty-nine different substitutions, co-localized at the active-site pocket area. The ceftazidime MIC (minimum inhibitory concentration levels and the relative frequency in the occurrence of substitutions did not correlate well with each other, and the latter appeared be largely influenced by the intrinsic mutational biases present in bacteria. Simulation studies suggested that all substitutions caused a congruent effect, expanding the space in a conserved structure called the omega loop, which in turn increased flexibility at the active site. A second phase of selection, in which the mutants were placed under increased antibiotic pressure, did not result in a second mutation in the coding region, but a mutation that increased gene expression arose in the promoter. This result suggests that the twelve amino acid positions and their specific substitutions in PenA may represent a comprehensive repertoire of the enzyme's adaptability to a new substrate. These mapped substitutions represent a comprehensive set of general mechanical paths to substrate spectrum expansion in class A β-lactamases that all share a functional evolutionary mechanism using common conserved residues.

  17. Dermatoglyphic pattern in male infertility.

    Science.gov (United States)

    Sontakke, B R; Talhar, S; Ingole, I V; Shende, M R; Pal, A K; Bhattacharaya, T

    2013-06-01

    Dermatoglyphics in infertile male patients were studied and compared with that of age matched controls to see whether any specific dermatoglyphic pattern exists in infertile male patients. Infertile male patients with abnormal semen profile were referred to Cytogenetic Laboratory for karyotyping. We selected twenty-four infertile male patients with abnormal semen profile. Out of twenty-four infertile male patients, nineteen were with normal Karyotype and five patients were with abnormal Karyotype. Loop was the commonest pattern observed in the infertile male patients. All these fingertip and palmar dermatoglyphic findings were compared with that of result on finger and palmar dermatoglyphics of equal number of age matched controls. Statistical evaluation was done with software "EPI- info, version-6.04 d". Infertile males had reduced number of loops as compared to that of controls which was statistically significant. Total whorls were increased in infertile male patients as compared to that of controls which was statistically insignificant. Percentage of true palmar pattern in I 3 and I 4 areas was reduced in infertile male patients as compared to that of controls which was statistically insignificant.

  18. Mountain Infantry - Is There a Need?

    Science.gov (United States)

    1988-06-03

    fail to realize this. LTC John Schmelzer , in his after action report on mountain warfare during World War II, states that "morale of the troops in...Evaluation, p.79. 62. U.S. Army, FM 100-5. Operatione, pp.12-13. 63. Schmelzer , p.2. 64. CPT Michael Robertson, "Briefing on the Force Design of the... Schmelzer . 1944. One of the best sources found. Provides keen insight into the struggles of the units in Italy as they fought the environment and the

  19. Bradley Infantry Fighting Vehicle Procedures Guides: Evaluation

    Science.gov (United States)

    1984-02-01

    can open and close fully and locks in both OPEN and CLOSED positions. 8. Check that safety pin is not missing. Internal fire suppression handles 9...that safety pin is not missing. Driver’s instrument panel 19. Check VOLTS gage. 20. Check ENGINE COOLANT TEMP gage. 21. Check ENGINE OIL gage. 22

  20. A Historical Perspective on Light Infantry

    Science.gov (United States)

    1987-01-01

    runners and signals. (Sometimes, battalion and company commanders enjoyed the use nf captured U.S. walkie-talkies.) Under these conditions, unyielding...concealed, The patrol element that discovered the CT@ kept the camp under surveillance and sent off a runner to inform the platoon leader or company...through a sparsely settled and thinly held maze of barren hills and ridges. German opposition consisted of scattered outposts leading back to a main line of

  1. Active Camouflage for Infantry Headwear Applications

    Science.gov (United States)

    2007-02-01

    3 The Barracuda Multispectral Ultra Lightweight Camouflage Screen (BMS-ULCAS) uses a garnishing material attached to a backing material (Jewish and...they work for more than one camouflage type. Barracuda Inc. has developed a multispectral camouflage product, the High Mobility on Board System

  2. Infantry Small-Unit Mountain Operations

    Science.gov (United States)

    2011-02-01

    webbing runners , 7-mm accessory cord, and a belay/rappel device. There are also static installation ropes, a rope cutter and a rope washer (Figure 5-4...with a harness, locking and non-locking carabineers, sewn webbing runners , mechanical ascenders, chock pick, assault climber bag, 7-mm accessory cord...for the build-up of ice from moisture in the breath and can mask the presence of frostbite. Shaving daily is necessary but using a blade and soap

  3. Canadian Light Infantry in Adaptive Dispersed Operations

    Science.gov (United States)

    2012-05-22

    Sources Bercuson, David . Significant Incident: Canada’s Army, the Airborne and the murder in Somalia. Toronto: McClelland and Stewart, 1996. Bernier...36 David Bercuson, Significant Incident: Canada’s Army, the Airborne and the Murder in Somalia...Toronto: McClelland and Stewart, 1996), 54-58. 37 Bernd Horn and M. Wyczynski, Hook-up! The Canadian Airborne Compendium (St.Catharines: Vanwell

  4. The aging male project

    Directory of Open Access Journals (Sweden)

    Farid Saad

    2001-06-01

    alpha estradiol have been synthesized some of which show selectivity for the central nervous system. CNS effects have been demonstrated in female and male animals. Cardiovascular protection by estrogens has been shown in animal and human studies. Atherosclerotic plaque size was reduced after estrogen injections in cholesterol-fed rabbits. Phytoestrogen-fed monkeys had lower total cholesterol and LDL cholesterol and higher HDL cholesterol. Apart from atherosclerotic lesions, coronary artery vascular reactivity was improved. Some of these experimental findings were confirmed in human studies in postmenopausal women with and without estrogen treatment. Whether all of the described estrogenic effects can be seen in men remains to be investigated. (Med J Indones 2001; 10: 127-33Keywords : aging, andropause, testosterone, estrogens

  5. Male tolerance and male-male bonds in a multilevel primate society.

    Science.gov (United States)

    Patzelt, Annika; Kopp, Gisela H; Ndao, Ibrahima; Kalbitzer, Urs; Zinner, Dietmar; Fischer, Julia

    2014-10-14

    Male relationships in most species of mammals generally are characterized by intense intrasexual competition, with little bonding among unrelated individuals. In contrast, human societies are characterized by high levels of cooperation and strong bonds among both related and unrelated males. The emergence of cooperative male-male relationships has been linked to the multilevel structure of traditional human societies. Based on an analysis of the patterns of spatial and social interaction in combination with genetic relatedness data of wild Guinea baboons (Papio papio), we show that this species exhibits a multilevel social organization in which males maintain strong bonds and are highly tolerant of each other. Several "units" of males with their associated females form "parties," which team up as "gangs." Several gangs of the same "community" use the same home range. Males formed strong bonds predominantly within parties; however, these bonds were not correlated with genetic relatedness. Agonistic interactions were relatively rare and were restricted to a few dyads. Although the social organization of Guinea baboons resembles that of hamadryas baboons, we found stronger male-male affiliation and more elaborate greeting rituals among male Guinea baboons and less aggression toward females. Thus, the social relationships of male Guinea baboons differ markedly from those of other members of the genus, adding valuable comparative data to test hypotheses regarding social evolution. We suggest that this species constitutes an intriguing model to study the predictors and fitness benefits of male bonds, thus contributing to a better understanding of the evolution of this important facet of human social behavior.

  6. Educating Black Males with Dyslexia

    Science.gov (United States)

    Robinson, Shawn Anthony

    2013-01-01

    Much of the scholarship on Black males in the educational literature focuses on the achievement gap; their underrepresentation in gifted and advanced placement programs; their overrepresentation in special education programs and their high rates of school suspensions and expulsions. Although overrepresented in special education, Black males with…

  7. Latino Males in Higher Education

    Science.gov (United States)

    Excelencia in Education, 2016

    2016-01-01

    This 2016 fact sheet profiles the status of Latino males in higher education, providing information on population, college enrollment, and educational attainment. While college enrollment among Latino males continues to increase, they still lag behind Latino females in college enrollment--a disparity that increases as the level of higher education…

  8. Cytoplasmic Male Sterility in Maize

    Institute of Scientific and Technical Information of China (English)

    RONG Ting-zhao; LI Wan-chen; CAO Mo-ju; HU Chang-yuan

    2002-01-01

    14 isoplasmic and allonuclear cytoplasmic male sterile lines were used as female parents, 8 tester lines as male parents, 101 F1 progenies were obtained. Fertility restoration response of 101 F1 progenies were investigated through field observation and pollen stainability examination under microscope. 14 isoplasmic and allonuclear cytoplasmic male sterile lines were developed by repeated backcross with recurrent male parent lines for more than 8 generations. The result shows: tester line Zifeng1 not only restored the isoplasmic and allonuclear sterile lines of group C backcrossed with Mo17, Yu30 and Heer, but also completely restored the isoplasmic and allonuclear cytoplasm male sterile lines of group T backcrossed with Mo17, HZS , 1792 ,292 and Yu30. Therefore, nuclear background limits the use of Zifeng1 as a tester for identification of cytoplasmic male sterility. Furthermore RFLPs of mitochondrial DNA of 6 isonuclear and alloplasmic cytoplasmic male sterile lines were analyzed with Bam H Ⅰ and Hind Ⅲ restriction endonuclease and mitochondrial DNA probes pBcmH3 and Cox Ⅱ. The same RFLPs were found within sterile cytoplasm of group C, including C,Chuan G, Lei 2 and Lei 3, but a different RFLP pattern was observed among sterile cytoplasm of group S, C,T and the normal cytoplasm. This result suggested that the RFLP markers tightly linked to sterile mitochondrial genes of different groups could be applied in the identifcation of cytoplasmic male sterility.

  9. Eating Disorders in Adolescent Males

    Science.gov (United States)

    Ray, Shannon L.

    2004-01-01

    Research indicates that the primary onset of eating disorders occurs in adolescence and that there is a growing prevalence of adolescent males with eating disorders. This article describes the eating disorders of anorexia nervosa and bulimia nervosa as they relate to adolescent males. Diagnostic criteria, at-risk groups, and implications for…

  10. Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Hogg Robert S

    2005-02-01

    Full Text Available Abstract Background Protease inhibitors are known to alter the lipid profiles in subjects treated for HIV/AIDS. However, the magnitude of this effect on plasma lipoproteins and lipids has not been adequately quantified. Objective To estimate the changes in plasma lipoproteins and triglycerides occurring within 12 months of initiating PI-based antiretroviral therapy among HIV/AIDS afflicted subjects. Methods We included all antiretroviral naïve HIV-infected persons treated at St-Paul's Hospital, British Columbia, Canada, who initiated therapy with protease inhibitor antiretroviral (ARV drugs between August 1996 and January 2002 and who had at least one plasma lipid measurement. Longitudinal associations between medication use and plasma lipids were estimated using mixed effects models that accounted for repeated measures on the same subjects and were adjusted for age, sex, time dependent CD4+ T-cell count, and time dependent cumulative use of non-nucleoside reverse transcriptase inhibitors and adherence. The cumulative number of prescriptions filled for PIs was considered time dependent. We estimated the changes in the 12 months following any initiation of a PI based regimen. Results A total of 679 eligible subjects were dispensed nucleoside analogues and PI at the initiation of therapy. Over a median 47 months of follow-up (interquartile range (IQR: 29–62, subjects had a median of 3 (IQR: 1–6 blood lipid measurements. Twelve months after treatment initiation of PI use, there was an estimated 20% (95% confidence interval: 17% – 24% increase in total cholesterol and 22% (12% – 33% increase in triglycerides. Conclusions Twelve months after treatment initiation with PIs, statistically significant increases in total cholesterol and triglycerides levels were observed in HIV-infected patients under conditions of standard treatment. Our results contribute to the growing body of evidence implicating PIs in the development of blood lipid

  11. [Clinical characteristics of male osteoporosis].

    Science.gov (United States)

    Yamauchi, Mika; Sugimoto, Toshitsugu

    2016-07-01

    As men are less likely than women to develop osteoporosis, male osteoporosis remains poorly understood. However, elderly men have a clearly reduced bone mineral density and increased risk for fractures. In Japan, one in four patients with osteoporosis is male. Male osteoporosis is associated with not only reduction in androgen, but also estrogen, and differs from postmenopausal osteoporosis in that decreased bone formation is involved and that age-related changes in cortical bone structure and perforation of the trabeculae of cancellous bone are unlikely to occur. The proportion of secondary osteoporosis is higher for men than women;therefore, differential diagnosis is important in the diagnosis of male osteoporosis. In addition, it is recommended that bone mineral density be measured at the femoral neck or total hip in men. Men have a worse prognosis following fractures than women, and management of male osteoporosis is highly important for extending healthy life expectancy.

  12. Is perceived parental monitoring associated with sexual risk behaviors of young Black males?

    Directory of Open Access Journals (Sweden)

    Richard Crosby

    2015-01-01

    Full Text Available This study determined whether perceived parental monitoring is associated with any of twelve selected outcomes related to sexual risk behaviors of young Black males. Recruitment occurred in clinics diagnosing and treating sexually transmitted infections. Young Black males living with a parent or guardian (N = 324 were administered a 9-item scale assessing level of perceived parental monitoring. The obtained range was 10–45, with higher scores representing more frequent monitoring. The mean was 29.3 (sd = 7.0. Eight of the twelve outcomes had significant associations with perceived parental monitoring (all in a direction indicating a protective effect. Of these eight, five retained significance in age-adjusted models were ever causing a pregnancy, discussing pregnancy prevention, safer sex, and condom use with sex partners, and using a condom during the last act of penile–vaginal sex. Monitoring by a parent figure may be partly protective against conceiving a pregnancy for Black males 15–23 years of age.

  13. 5S rDNA characterization in twelve Sciaenidae fish species (Teleostei, Perciformes: depicting gene diversity and molecular markers

    Directory of Open Access Journals (Sweden)

    Fernanda A. Alves-Costa

    2008-01-01

    Full Text Available In order to extend the genetic data on the Sciaenidae fish family, the present study had the purpose to characterize PCR-generated 5S rDNA repeats of twelve species of this group through PAGE (Polyacrylamide Gel Electrophoresis analysis. The results showed the occurrence of at least two different 5S rDNA size classes in all the species. Moreover, 5S rDNA repeats of one of the studied species - Isopisthus parvipinnis - were cloned and subjected to nucleotide sequencing and Southern blot membrane hybridization analyses, which permitted to confirm the existence of two major 5S rDNA classes. Phylogenetic analysis based on the nucleotide sequences of different 5S rDNA repeats of I. parvipinnis lead to their separation into two major clusters. These results may reflect the high dynamism that rules the evolution rate of 5S rDNA repeats. The obtained data suggest that 5S rDNA can be useful in genetic analyses to identify species-specific markers and determine relationships among species of the Sciaenidae group.

  14. Uptake of radionuclide thorium by twelve native plants grown in uranium mill tailings soils from south part of China

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Xun, E-mail: m13836295186@163.com

    2016-08-01

    Highlights: • Screen dominant plants grown in uranium mill tailings soils. • Quantify the content of {sup 232}Th of soil samples from uranium mill tailings. • Quantify the transfer factor, bioconcentration factor and phytoremediation factor. • Screen out the plant species capable of remediating radionuclide contaminated soils. • Guide the reuse of study area in future. - Abstract: The concentrations of thorium ({sup 232}Th) in soil from a uranium mill tailings repository in South China were analyzed. The results showed that all the soil samples were acidic and the concentrations of {sup 232}Th in all the soil samples were more than the natural radionuclide content in soil of China. Through the field investigation, twelve kinds of dominant plants were discovered. The total quantity of {sup 232}Th in the whole plant is highest in rice flat sedge. We also found that Miscanthus floridulus has the greatest transfer factor (TF) for {sup 232}Th, rice flat sedge has the greatest bioconcentration factor (BF) for {sup 232}Th. At the mean time, M. floridulus has the greatest phytoremediation factor (PF) for {sup 232}Th. On the basis of the above conclusions and the definition for hyperaccumulator, rice flat sedge and M. floridulus could be the candidates of phytoremediation for radionuclide {sup 232}Th in the soil.

  15. Videofluoroscopy of the oral phase of swallowing in eight to twelve years old children with dental malocclusion.

    Science.gov (United States)

    Junqueira, Patricia; Costa, Milton Melciades

    2013-11-01

    The objective of this study was to describe the oral phase of swallowing in individuals with dental malocclusion and to generate data that would contribute to the rehabilitation of those patients. The study was based on the evaluation of the swallowing system through videofluoroscopy on thirty-four children of both genders, aged eight to twelve years old who present with Angle Class II and III dental malocclusions. Thirteen children of similar age and gender presenting normal dental occlusion formed the control group. The results indicated that the oral phase of swallowing is different between individuals with normal occlusion and malocclusion. Dental occlusion types Angle Class II and III did not present a swallowing pattern, independently of the amount of liquid ingested. The swallowing appeared effective in the oral phase of individuals with dental malocclusion, even though adaptations were identified. The outcome, in the absence of a single pattern and the efficiency of the adapted swallowing demonstrates, first a need for additional research investigating orofacial myofunctional treatment for patients with malocclusion and second how such analyses should focus on contributing positively to the rehabilitation of these patients.

  16. Advanced LIGO Two-Stage Twelve-Axis Vibration Isolation and Positioning Platform. Part 2: Experimental Investigation and Tests Results

    CERN Document Server

    Matichard, Fabrice; Mason, Kenneth; Mittleman, Richard; Abbott, Benjamin; Abbott, Samuel; Allwine, Eric; Barnum, Samuel; Birch, Jeremy; Biscans, Sebastien; Clark, Daniel; Coyne, Dennis; DeBra, Dan; DeRosa, Ryan; Foley, Stephany; Fritschel, Peter; Giaime, Joseph A; Gray, Corey; Grabeel, Gregory; Hanson, Joe; Hillard, Michael; Kissel, Jeffrey; Kucharczyk, Christopher; Roux, Adrien Le; Lhuillier, Vincent; Macinnis, Myron; OReilly, Brian; Ottaway, David; Paris, Hugo; Puma, Michael; Radkins, Hugh; Ramet, Celine; Robinson, Mitchell; Ruet, Laurent; Sareen, Pradeep; Shoemaker, Daivid; Stein, Andy; Thomas, Jeremy; Vargas, Michael; Warner, Jimmy

    2014-01-01

    This paper presents the results of the past seven years of experimental investigation and testing done on the two-stage twelve-axis vibration isolation platform for Advanced LIGO gravity waves observatories. This five-ton two-and-half-meter wide system supports more than a 1000 kg of very sensitive equipment. It provides positioning capability and seismic isolation in all directions of translation and rotation. To meet the very stringent requirements of Advanced LIGO, the system must provide more than three orders of magnitude of isolation over a very large bandwidth. It must bring the motion below 10^(-11) m/(Hz)^0.5 at 1 Hz and 10^(-12) m/(Hz)^0.5 at 10 Hz. A prototype of this system has been built in 2006. It has been extensively tested and analyzed during the following two years. This paper shows how the experimental results obtained with the prototype were used to engineer the final design. It highlights how the engineering solutions implemented not only improved the isolation performance but also greatl...

  17. Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Allen, David; Milanowski, Janusz;

    2004-01-01

    : There was no significant difference in mean adjusted growth rates between the 2 groups: 84.0 mm/year in the FP group versus 86.4 mm/year in the SCG group (difference FP-SCG: -2.4 mm/year; 95% confidence interval: -6.6 to 1.8). Growth comparisons were independent of age, gender, previous use of steroid, or whether measured......, exacerbations, and requirements for oral steroid treatment and more symptom-free days and days without use of rescue treatment. CONCLUSIONS: Twelve months of treatment with inhaled FP (100 microg twice daily) in preschool children aged 1 to 3 years with recurrent wheeze has no effect on growth and no other......OBJECTIVE: Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze. METHODS: The study was a randomized, parallel-group, open-label multicenter study of 625 children...

  18. A First Assessment of Mycobacterium tuberculosis Genetic Diversity and Drug-Resistance Patterns in Twelve Caribbean Territories

    Directory of Open Access Journals (Sweden)

    Julie Millet

    2014-01-01

    Full Text Available With the exception of some French-speaking islands, data on tuberculosis (TB in the Caribbean are scarce. In this study, we report a first assessment of genetic diversity of a convenience sample of Mycobacterium tuberculosis strains received from twelve Caribbean territories by spoligotyping and describe their drug-resistance patterns. Of the 480 isolates, 40 (8.3% isolates showed resistance to at least one anti-TB drug. The proportion of drug-resistant strains was significantly higher in The Bahamas (21.4%; P=0.02, and Guyana (27.5%; P<0.0001, while it was significantly lower in Jamaica (2.4%; P=0.03 than in other countries of the present study. Regarding genetic diversity, 104 distinct spoligotype patterns were observed: 49 corresponded to clustered strains (2 to 93 strains per cluster, while 55 remained unclustered among which 16 patterns were not reported previously. Combining the study results with regional data retrieved from the international SITVIT2 database underlined a connection between frequency of certain M. tuberculosis phylogenetic lineages and the language spoken, suggesting historical (colonial and ongoing links (trade, tourism, and migratory flows with European countries with which they shared a common past.

  19. Measuring performance in off-patent drug markets: a methodological framework and empirical evidence from twelve EU Member States.

    Science.gov (United States)

    Kanavos, Panos

    2014-11-01

    This paper develops a methodological framework to help evaluate the performance of generic pharmaceutical policies post-patent expiry or after loss of exclusivity in non-tendering settings, comprising five indicators (generic availability, time delay to and speed of generic entry, number of generic competitors, price developments, and generic volume share evolution) and proposes a series of metrics to evaluate performance. The paper subsequently tests this framework across twelve EU Member States (MS) by using IMS data on 101 patent expired molecules over the 1998-2010 period. Results indicate that significant variation exists in generic market entry, price competition and generic penetration across the study countries. Size of a geographical market is not a predictor of generic market entry intensity or price decline. Regardless of geographic or product market size, many off patent molecules lack generic competitors two years after loss of exclusivity. The ranges in each of the five proposed indicators suggest, first, that there are numerous factors--including institutional ones--contributing to the success of generic entry, price decline and market penetration and, second, MS should seek a combination of supply and demand-side policies in order to maximise cost-savings from generics. Overall, there seems to be considerable potential for faster generic entry, uptake and greater generic competition, particularly for molecules at the lower end of the market.

  20. Chemical Abundances in Twelve Red Giants of the Large Magellanic Cloud from High-Resolution Infrared Spectroscopy

    CERN Document Server

    Smith, V V; Cunha, K; Plez, B; Lambert, D L; Pilachowski, C A; Barbuy, B; Melendez, J; Balachandran, S C; Bessell, M S; Geisler, D; Hesser, J E; Winge, C

    2002-01-01

    High-resolution infrared spectra (R=50,000) have been obtained for twelve red-giant members of the LMC with the Gemini South 8.3-meter telescope plus Phoenix spectrometer. Quantitative chemical abundances of carbon-12, carbon-13, nitrogen-14, and oxygen-16 were derived from molecular lines of CO, CN, and OH, while sodium, scandium, titanium, and iron abundances were derived from neutral atomic lines. The LMC giants have masses from about 1 to 4 solar masses and span a metallicity range from [Fe/H]= -1.1 to -0.3. The program red giants all show evidence of first dredge-up mixing, with low 12C/13C ratios, and low 12C correlated with high 14N abundances. Comparisons of the oxygen-to-iron ratios in the LMC and the Galaxy indicate that the trend of [O/Fe] versus [Fe/H] in the LMC falls about 0.2 dex below the Galactic trend. Such an offset can be modeled as due to an overall lower rate of supernovae per unit mass in the LMC relative to the Galaxy, as well as a slightly lower ratio of supernovae of type II to super...

  1. Protein and energy metabolism of young male Wistar rats fed conjugated linoleic acid as structured triacylglycerol

    DEFF Research Database (Denmark)

    Jørgensen, H.; Hansen, C. H.; Mu, Huiling

    2010-01-01

    Twelve 4-week-old male Wistar rats weighing 100 g were fed diets semi-ad libitum for 22 d containing either 1.5% conjugated linoleic acid (CLA-diet) or high oleic sunflower oil (Control-diet). The CLA was structured triacylglycerol with predominantly cis-9, trans-11 and trans-10, cis-12 fatty aci...... isomers in the inner position and oleic acid in the other positions of the glycerol molecule. The rats were kept individually in metabolic cages. From days 8-16 energy, nitrogen (N) and carbon...

  2. Smokeless tobacco use by middle school males: a preliminary test of the reasoned action theory.

    Science.gov (United States)

    Brubaker, R G; Loftin, T L

    1987-02-01

    This study identified psychosocial variables associated with smokeless tobacco use within the context of the reasoned action theory. One hundred twelve male students, ages ten-14, completed a questionnaire that operationalized components of the theoretical model. Multiple regression analyses revealed intention to use smokeless tobacco correlated significantly with attitude toward the behavior and perceived social pressure. As predicted by the theory, significant differences between those who intended to use smokeless tobacco and those who did not were found on several outcome and normative beliefs. The data support the utility of the theory as a means of explaining smokeless tobacco use. Future research recommendations are offered.

  3. The effect of high-intensity intermittent exercise on body composition of overweight young males.

    Science.gov (United States)

    Heydari, M; Freund, J; Boutcher, S H

    2012-01-01

    To determine the effect of a 12-week high intensity intermittent exercise (HIIE) intervention on total body, abdominal, trunk, visceral fat mass, and fat free mass of young overweight males. Participants were randomly assigned to either exercise or control group. The intervention group received HIIE three times per week, 20 min per session, for 12 weeks. Aerobic power improved significantly (P 0.05) occurred in levels of insulin, HOMA-IR, and blood lipids. Twelve weeks of HIIE resulted in significant reductions in total, abdominal, trunk, and visceral fat and significant increases in fat free mass and aerobic power.

  4. Cardiovascular and neuroendocrine responses to left lateral position in non-obese young males

    DEFF Research Database (Denmark)

    Schou, M; Pump, B; Gabrielsen, A

    2001-01-01

    through peripheral vasodilatation induced by cardiopulmonary low-pressure receptor stimulation. Twelve non-obese young males were investigated. The location of the mid-aorta between the aortic valves was used as the hydrostatic reference point for the arterial pressure measurements. It was determined...... rebreathing), heart rate, and plasma concentrations (n=6) of vasoactive hormones were unchanged by LAT. In conclusion, cardiac output, mean arterial pressures, and vasoactive hormone releases were unaffected by 30 min of LAT. Furthermore, the hydrostatic reference points for arterial pressure measurements...

  5. Higher dopamine level enhances male-male courtship in Drosophila

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ On May 21 2008, Journal of Neuroscience published an online paper from the Institute of Neuroscience, the CAS Shanghai Institutes for Biological Sciences, entitled "Increased dopamine level enhances male-male courtship in Drosophila." This work was done by Mr. LIU Tong, a doctoral candidate, and colleagues under the supervision of Dr. GUO Aike, and in collaboration with Dr. Jean-Francois Ferveur from France.

  6. How Effective Is Male Contraception?

    Science.gov (United States)

    ... Clinical Trials Resources and Publications How effective is male contraception? Skip sharing on social media links Share this: Page Content Not all contraceptive methods are appropriate for all situations, and individuals ...

  7. Screening of Genes Specifically Expressed in Males of Fenneropenaeus chinensis and Their Potential as Sex Markers

    Directory of Open Access Journals (Sweden)

    Shihao Li

    2013-01-01

    Full Text Available The androgenic gland (AG, playing an important role in sex differentiation of male crustacean, is a target candidate to understand the mechanism of male development and to mine male-specific sex markers. An SSH library (designated as male reproduction-related tissues—SSH library, MRT-SSH library for short was constructed using cDNA from tissues located at the basal part of the 5th pereiopods, including AG and part of spermatophore sac, as tester, and the cDNA from the basal part of the 4th pereiopods of these male shrimp as driver. 402 ESTs from the SSH library were sequenced and assembled into 48 contigs and 104 singlets. Twelve contigs and 14 singlets were identified as known genes. The proteins encoded by the identified genes were categorized, according to their proposed functions, into neuropeptide hormone and hormone transporter, RNA posttranscriptional regulation, translation, cell growth and death, metabolism, genetic information processing, signal transduction/transport, or immunity-related proteins. Eleven highly expressed contigs in the SSH library were selected for validation of the MRT-SSH library and screening sex markers of shrimp. One contig, specifically expressed in male shrimp, had a potential to be developed as a transcriptomic sex marker in shrimp.

  8. Symbiotic interactions between arbuscular mycorrhizal (AM) fungi and male papaya plants: its status, role and implications.

    Science.gov (United States)

    Khade, Sharda W; Rodrigues, Bernard F; Sharma, Prabhat K

    2010-01-01

    Experiments were conducted to study the arbuscular mycorrhizal (AM) status and its role in P-uptake through assay of root phosphatases activities in four varieties of male Carica papaya L. viz. CO-1, CO-2, Honey Dew and Washington during flowering stages. In the present study, mean total root colonization of AM fungi recorded peak increase in flowering stage-II while mean root phosphatase (acid and alkaline) activities recorded peak increase in flowering stage-I. Unlike root colonization and root phosphatase activities, spore density did not exhibit any definite patterns and recorded a narrow range of fluctuation during different flowering stages of male C. papaya. The study brought out the fact that root colonization and spore density of AM fungi along with root phosphatase activities varied significantly within the four varieties of male C. papaya plants during each flowering stage. The study also recorded consistently higher acid root phosphatase activity than alkaline root phosphatase activity under P-deficient, acidic soil conditions during all flowering stages of male C. papaya plants. Studies revealed that the root colonization of AM fungi influenced root phosphatase activities (acid and alkaline) positively and significantly during all flowering stages of male C. papaya plants. A total of twelve species of AM fungi belonging to five genera viz. Acaulospora, Dentiscutata, Gigaspora, Glomus, and Racocetra were recovered from the rhizosphere of male C. papaya plants.

  9. 12 Daghem: Beskrivning av uppfostringsklimat och sociala relationer (Twelve Day Care Centers: A Multisite Comparison of Day-Care Climate and Social Relations).

    Science.gov (United States)

    Ekholm, Bodil; Hedin, Anna

    Twelve day care centers in a Swedish commune were systematically observed. Centers were selected on the basis of responses to a questionnaire on attitudes about upbringing which was answered by all the personnel at the 104 day care centers in the commune. Four of the selected centers represented a so-called "present-focused" upbringing…

  10. Androgens and the ageing male

    DEFF Research Database (Denmark)

    Juul, Anders; Skakkebaek, Niels E

    2002-01-01

    Hypogonadal men share a variety of signs and symptoms such as decreased muscle mass, osteopoenia, increased fat mass, fatigue, decreased libido and cognitive dysfunctions. Controlled trials have demonstrated favourable effects of androgen substitution therapy on these signs and symptoms in men wi...... in some elderly males with low-normal testosterone levels. However, at this point in time, widespread use of testosterone in an elderly male population outside controlled clinical trials seems inappropriate....

  11. Male Genitoplasty for Intersex Disorders

    OpenAIRE

    2008-01-01

    Aim. To evaluate surgical procedures adopted for male genitoplasty in intersex disorders. Patients and Methods. Case records of intersex patients undergoing male genitoplasty from Pediatric Intersex clinic were studied. Results. Of 356 intersex cases undergoing urethroplasty from 1989–2007, the hypospadias was penoscrotal (68%), scrotal (17%) and perineal (15%). 351 patients underwent chordee correction for mild: moderate: severe chordee in 24 : 136 : 191 cases. Byars...

  12. Male Breast Adenoid Cystic Carcinoma

    Directory of Open Access Journals (Sweden)

    Seung Jin Yoo

    2013-10-01

    Full Text Available Introduction: Adenoid cystic carcinoma (ACC of the breast is a rare condition, and cases in male patients are even less common. Case: We describe a case of ACC of the breast with axillary lymph node metastasis, disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year-old man. Conclusion: Male breast ACC is an extremely rare malignancy; there can be difficulty in obtaining a final diagnosis. We report this case because of its rarity.

  13. Adolescent Male Human Papillomavirus Vaccination

    Directory of Open Access Journals (Sweden)

    Vivian C. Nanagas MD, MSc

    2016-04-01

    Full Text Available Objective. To determine male vaccination rates with quadrivalent human papillomavirus vaccine (HPV4 before and after the October 2011 national recommendation to routinely immunize adolescent males. Methods. We reviewed HPV4 dose 1 (HPV4-1 uptake in 292 adolescent males in our urban clinic prior to national recommendations and followed-up for HPV4 series completion rates. After national recommendation, 248 urban clinic and 247 suburban clinic males were reviewed for HPV4-1 uptake. Factors associated with HPV4-1 refusal were determined with multiple logistic regression. Results. Of the initial 292 males, 78% received HPV4-1 and 38% received the 3-dose series. After recommendation, HPV4-1 uptake was 59% and 7% in urban and suburban clinics, respectively. Variables associated with HPV4-1 uptake/refusal included time period, race, type of insurance, and receipt of concurrent vaccines. Conclusions. HPV4-1 vaccination rates in our urban clinic were high before and after routine HPV vaccine recommendations for adolescent males. Our vaccination rates were much higher than in a suburban practice.

  14. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Lourenço, Charles Marques; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Sang, Kim-Hanh Le Quan; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650-85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy.

  15. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease' in Italy

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Marques Lourenço, Charles; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Le Quan Sang, Kim-Hanh; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650–85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy. PMID:25804398

  16. Dual-resolution Raman spectroscopy for measurements of temperature and twelve species in hydrocarbon–air flames

    Energy Technology Data Exchange (ETDEWEB)

    Magnotti, Gaetano; Barlow, Robert S.

    2016-07-12

    This study introduces dual-resolution Raman spectroscopy as a novel diagnostics approach for measurements of temperature and species in flames where multiple hydrocarbons are present. Simultaneous measurement of multiple hydrocarbons is challenging because their vibrational Raman spectra in the C–H stretch region are closely overlapped and are not well known over the range of temperature encountered in flames. Overlap between the hydrocarbon spectra is mitigated by adding a second spectrometer, with a higher dispersion grating, to collect the Raman spectra in the C–H stretch region. A dual-resolution Raman spectroscopy instrument has been developed and optimized for measurements of major species (N2, O2, H2O, CO2, CO, H2, DME) and major combustion intermediates (CH4, CH2O, C2H2, C2H4 and C2H6) in DME–air flames. The temperature dependences of the hydrocarbon Raman spectra over fixed spectral regions have been determined through a series of measurements in laminar Bunsen-burner flames, and have been used to extend a library of previously acquired Raman spectra up to flame temperature. The paper presents the first Raman measurements of up to twelve species in hydrocarbon flames, and the first quantitative Raman measurements of formaldehyde in flames. Lastly, the accuracy and precision of the instrument are determined from measurements in laminar flames and the applicability of the instrument to turbulent DME–air flames is discussed.

  17. [Effect of broken black tea on the formation of dental enamel and the contents of twelve kinds of chemical elements].

    Science.gov (United States)

    Cao, Jin; Yao, Zhigang; Yi, Juan; Zhao, Yan; Zhong, Jie; Yuan, Huabing

    2009-11-01

    The aim of this study was to investigate the effect of broken black tea with slightly hyper-normal fluoride content which was near the level of people tea-drinking habits on enamel morphological structure and its content of chemical elements. Thirty six rats were divided randomly into 3 groups: one was control group and another two groups fed with broken black tea infusion with F- content of 8.2 mg/l and 16.4 mg/l, respectively. After 360 days, collected 144 teeth, observed their morphological structure by electron micrograph, Scanning electron micrographs (SEM) and also analyzed concentrations of several chemical elements in tooth by x-ray fluorescence spectrometry (XRF). Chronic dental fluorosis in rats was induced by treatment with broken black tea with slightly hyper-normal fluoride content. Hyper-calcification and hypo-calcification appeared in enamel of those teeth from both broken black tea treated groups in dose-dependent manner. Twelve kinds of chemical elements, such as Ca, Mg, P, Al, Cl were examined. The contents of Ca, P, Mg were reduced and that of Al and Cl were increased significantly. Compared with control group, the levels of Si, S, Fe were lower in those teeth from treated group (broken black tea with the F- content of 8.2 mg/l), while higher in those teeth from treated group (broken black tea with the F- content of 16.4 mg/l). Long-term drinking broken black tea with hyper-normal fluoride content could cause chronic dental fluorosis, and its injury in enamel was related with Hyper-calcification and hypo-calcification mainly. Those changes of several chemical elements level in enamel, such as Ca, P, Al, Cl, were suggested that these chemical elements have influences on the development and mineralization of enamel.

  18. Monitoring field susceptibility to imidacloprid in the cat flea: a world-first initiative twelve years on.

    Science.gov (United States)

    Kopp, Steven; Blagburn, Byron; Coleman, Glen; Davis, Wendell; Denholm, Ian; Field, Chris; Hostetler, Joe; Mencke, Norbert; Rees, Robert; Rust, Michael; Schroeder, Iris; Tetzner, Kathrin; Williamson, Martin

    2013-08-01

    In 2001, an international surveillance initiative was established, utilising a validated larval development inhibition assay to track the susceptibility of cat flea isolates to imidacloprid. In 2009, an Australian node was incorporated into the programme, joining laboratories in the United States and Europe. Field isolates of Ctenocephalides felis eggs were submitted to participating laboratories and, where egg quantity and quality was sufficient, were placed in the imidacloprid discriminating dose bioassay for evaluation. Between 2002 and 2012, a total of 2,307 cat flea isolates were received across all sites; 1,685 submissions (73 %) were suitable for placement into the bioassay. In the Northern Hemisphere, isolate submission rate was influenced by season, with highest numbers submitted between June and October. In Australia, pets with flea infestations could be sourced year-round, and submission rate was largely influenced by programme factors and not climate. A total of 1,367 valid assays were performed between 2002 and 2012 (assay validity data was not recorded in 2001); adult flea emergence 5 % or greater at 3 ppm imidacloprid was observed in 38 of these assays (2.8 %). For these isolates that reached the threshold for further investigation, re-conduct of the assay using either a repeat challenge dose of 3 ppm of imidacloprid or a dose response probit analysis confirmed their susceptibility to imidacloprid. From 2009 to 2012, the Australian node performed valid assays on 97 field isolates from a total of 136 submissions, with no adult emergence observed at the 3-ppm imidacloprid discriminating dose. In addition to reviewing the data generated by this twelve-year initiative, this paper discusses lessons learned from the coordination and evolution of a complex project across geographically dispersed laboratories on three continents.

  19. Functional roles and substrate specificities of twelve cytochromes P450 belonging to CYP52 family in n-alkane assimilating yeast Yarrowia lipolytica.

    Science.gov (United States)

    Iwama, Ryo; Kobayashi, Satoshi; Ishimaru, Chiaki; Ohta, Akinori; Horiuchi, Hiroyuki; Fukuda, Ryouichi

    2016-06-01

    Yarrowia lipolytica possesses twelve ALK genes, which encode cytochromes P450 in the CYP52 family. In this study, using a Y. lipolytica strain from which all twelve ALK genes had been deleted, strains individually expressing each of the ALK genes were constructed and their roles and substrate specificities were determined by observing their growth on n-alkanes and analyzing fatty acid metabolism. The results suggested that the twelve Alk proteins can be categorized into four groups based on their substrate specificity: Alk1p, Alk2p, Alk9p, and Alk10p, which have significant activities to hydroxylate n-alkanes; Alk4p, Alk5p, and Alk7p, which have significant activities to hydroxylate the ω-terminal end of dodecanoic acid; Alk3p and Alk6p, which have significant activities to hydroxylate both n-alkanes and dodecanoic acid; and Alk8p, Alk11p, and Alk12p, which showed faint or no activities to oxidize these substrates. The involvement of Alk proteins in the oxidation of fatty alcohols and fatty aldehydes was also analyzed by measuring viability of the mutant deleted for twelve ALK genes in medium containing dodecanol and by observing growth on dodecanal of a mutant strain, in which twelve ALK genes were deleted along with four fatty aldehyde dehydrogenase genes. It was suggested that ALK gene(s) is/are involved in the detoxification of dodecanol and the assimilation of dodecanal. These results imply that genes encoding CYP52-family P450s have undergone multiplication and diversification in Y. lipolytica for assimilation of various hydrophobic compounds.

  20. Bilateral male breast cancer with male potential hypogonadism

    Directory of Open Access Journals (Sweden)

    Kurokawa Yasushi

    2007-06-01

    Full Text Available Abstract Background Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases. Case presentation The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potential hypogonadism, and these hormonal abnormalities seemed to be present since childhood or the fetal period. The bilateral breast cancer developed in this man at a comparatively young age, and histopathological studies of multiple sections showed that there was almost no normal epithelial cell in the ducts, while the ducts were almost completely filled with breast cancer cells. Conclusion It is thought that male breast cancer is caused by an imbalance between estrogen and testosterone. We cannot rule out the possibility that the breast cancer developed due to the effect of the slight elevation of estrogen over a long period of time, but the actual causative factors in this patient were unable to be definitively identified. In the future, we hope to further elucidate the causes of male breast cancer.

  1. A retrospective evaluation of the quality of malaria case management at twelve health facilities in four districts in Zambia

    Institute of Scientific and Technical Information of China (English)

    Pascalina Chanda-Kapata; Emmanuel Chanda; Freddie Masaninga; Annette Habluetzel; Felix Masiye; Ibrahima Soce Fall

    2014-01-01

    Objective: To establish the appropriateness of malaria case management at health facility level in four districts in Zambia. Methods: This study was a retrospective evaluation of the quality of malaria case management at health facilities in four districts conveniently sampled to represent both urban and rural settings in different epidemiological zones and health facility coverage. The review period was from January to December 2008. The sample included twelve lower level health facilities from four districts. The Pearson Chi-square test was used to identify characteristics which affected the quality of case management.Results:Out of 4891 suspected malaria cases recorded at the 12 health facilities, more than 80% of the patients had a temperature taken to establish their fever status. About 67% (CI95 66.1-68.7) were tested for parasitemia by either rapid diagnostic test or microscopy, whereas the remaining 22.5% (CI95 21.3.1-23.7) were not subjected to any malaria test. Of the 2247 malaria cases reported (complicated and uncomplicated), 71% were parasitologically confirmed while 29% were clinically diagnosed (unconfirmed). About 56% (CI95 53.9-58.1) of the malaria cases reported were treated with artemether-lumefantrine (AL), 35% (CI95 33.1-37.0) with sulphadoxine-pyrimethamine, 8% (CI95 6.9-9.2) with quinine and 1% did not receive any anti-malarial. Approximately 30% of patients WHO were found negative for malaria parasites were still prescribed an anti-malarial, contrary to the guidelines. There were marked inter-district variations in the proportion of patients in WHOm a diagnostic tool was used, and in the choice of anti-malarials for the treatment of malaria confirmed cases. Association between health worker characteristics and quality of case malaria management showed that nurses performed better than environmental health technicians and clinical officers on the decision whether to use the rapid diagnostic test or not. Gender, in service training on malaria

  2. Focus Issue on Male Infertility

    Directory of Open Access Journals (Sweden)

    Hideyuki Kobayashi

    2012-01-01

    Full Text Available Male infertility problems can occur when sperms are limited in number or function. In this paper, we describe the clinical evaluation of male infertility. A detailed history, physical examination, and basic semen analysis are required. In addition, ultrasound, karyotyping, and hormonal studies are needed to determine specific causes of infertility. In addition, the World Health Organization (WHO, 2009 has developed a manual to provide guidance in performing a comprehensive semen analysis. Among the possible reasons for male infertility, nonobstructive azoospermia is the least treatable, because few or no mature sperm may be produced. In many cases, men with nonobstructive azoospermia typically have small-volume testes and elevated FSH. Although treatment may not completely restore the quality of semen from men with subnormal fertility, in some cases a successful pregnancy can still be achieved through assisted reproductive technology.

  3. XYY male and hematologic malignancy.

    Science.gov (United States)

    Oguma, N; Shigeta, C; Kamada, N

    1996-09-01

    Two cases of XYY male with refractory anemia with excess of blasts are reported, and previous reported XYY males with hematologic malignancy are reviewed. Altogether 26 cases were collected for analysis: acute myeloid leukemia (10), acute lymphocytic leukemia (seven), acute leukemia (two), chronic myelocytic leukemia (three), myelodysplastic syndrome (three), and essential thrombocythemia (one). The age at the time of diagnosis ranged in age from 7.5 to 81 years. In three of six XYY/XY mosaicism cases, XYY clone was associated with malignancy. However, in two cases XYY clone was not involved. The evidence presented here suggests that the event of an XYY male with hematologic malignancy is incidental rather than a genetic etiology.

  4. Management of male breast cancer

    Directory of Open Access Journals (Sweden)

    Nikolay V. Dimitro v

    2011-12-01

    Full Text Available The management of male breast cancer is still under discussion due to lack of information from prospective, randomized clinical trials and low incidence of this disease. Current management is based largely on extrapolation from data related to treatment of female breast cancer. Over the last two decades, several review articles have discussed mainly retrospective and anecdotal data related to hormonal and chemotherapy treatment modalities. In this review, we present the most recent information and future considerations related to the management of male breast cancer. In addition to the conventional treatment options we will discuss the possible role of targeted therapy. Establishing a national or global registry for male breast cancer will provide more precise information about the natural history of the disease and will facilitate the design and execution of prospective, randomized multicenter clinical trials.

  5. Familial aspects of male homosexuality.

    Science.gov (United States)

    Dawood, K; Pillard, R C; Horvath, C; Revelle, W; Bailey, J M

    2000-04-01

    Research has generally supported the existence of familial-genetic factors for male sexual orientation, but has not shed much light on the specific nature of those influences. Gay men with gay brothers provide the opportunity to examine several hypotheses. Sixty-six men, representing 37 gay male sibling pairs, completed questionnaires assessing behavior on various measures including childhood and adult gender nonconformity, timing of awareness of homosexual feelings, self-acceptance, and the quality of family relationships. Consistent with prior findings using twins, gay brothers were similar in their degree of childhood gender non-conformity, suggesting that this variable may distinguish etiologically (e.g., genetically) heterogeneous subtypes. The large majority of gay men with brothers knew about their own homosexual feelings before they learned about their brothers' homosexual feelings, suggesting that discovery of brothers' homosexuality is not an important cause of male homosexuality.

  6. Genetic causes of male infertility.

    Science.gov (United States)

    Stouffs, Katrien; Seneca, Sara; Lissens, Willy

    2014-05-01

    Male infertility, affecting around half of the couples with a problem to get pregnant, is a very heterogeneous condition. Part of patients are having a defect in spermatogenesis of which the underlying causes (including genetic ones) remain largely unknown. The only genetic tests routinely used in the diagnosis of male infertility are the analyses for the presence of Yq microdeletions and/or chromosomal abnormalities. Various other single gene or polygenic defects have been proposed to be involved in male fertility. Yet, their causative effect often remains to be proven. The recent evolution in the development of whole genome-based techniques may help in clarifying the role of genes and other genetic factors involved in spermatogenesis and spermatogenesis defects. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  7. Male genital trauma in sports.

    Science.gov (United States)

    Hunter, Stanley R; Lishnak, Timothy S; Powers, Andria M; Lisle, David K

    2013-04-01

    Male genital trauma is a rare but potentially serious sports injury. Although such an injury can occur by many different mechanisms, including falls, collisions, straddle injuries, kicks, and equipment malfunction, the clinical presentation is typically homogeneous, characterized by pain and swelling. Almost all sports-related male genital injury comes from blunt force trauma, with involvement of scrotal structures far more common than penile structures. Most injuries can be treated conservatively, but catastrophic testicular injury must first be ruled out. Despite being relatively uncommon compared with other sports injuries, more than half of all testicular injuries are sustained during sports.

  8. [Genetic evaluation of male homosexuality].

    Science.gov (United States)

    Gasztonyi, Z

    1998-02-01

    The family trees of 16 homosexual males are evaluated in the material of their Genetic Counselling Clinic. The familial cluster of three cases corresponded to the X-linked recessive inheritance. The results of family, twin and adoption studies are reviewed and the recent findings of molecular genetic and brain researches are summarised. Male homosexuality comprises of different subgroups, but one major entity is caused by X-linked recessive gene(s). This genetic background represent a predisposition which is triggered or suppressed by external factors.

  9. Novel concepts in male infertility

    Directory of Open Access Journals (Sweden)

    Sandro C. Esteves

    2011-02-01

    Full Text Available Extraordinary advances have been achieved in the field of male infertility in the last decades. There are new concepts in sperm physiology and several modern tools for the assessment of spermatogenesis kinetics in vivo. New tests using molecular biology and DNA damage assays allow the clinician to correctly diagnose men so far classified as having idiopathic male infertility. In the field of treatment, microsurgery has increased success rates either for reconstruction of the reproductive tract or the retrieval of spermatozoa for assisted conception. Emerging evidence suggests that life-style and environmental conditions are of utmost importance in male fertility and subfertility. This review discusses several concepts that have changed over the last years, such as the duration of the spermatogenic cycle in humans, Y-chromosome infertility, the reproductive potential of non-mosaic Klinefelter syndrome men, the impact of paternal age and sperm DNA in male infertility, the role of antioxidants in the treatment of infertile men, the predictive factors and techniques for sperm retrieval in non-obstructive azoospermia, and the microsurgical treatment of clinical varicoceles. Whenever possible, levels of evidence are provided as suggested by the Oxford Center of Evidence-based Medicine.

  10. Gay Male Fantasies and Realities.

    Science.gov (United States)

    Lehne, Gregory K.

    1978-01-01

    In this study of 47 gay men, it was found that early sexual fantasies preceded interpersonal sexual experience by an average of four years and functioned as a source of self-knowledge. Current affectional and fantasy themes were related to respondents' lifestyles or desire for a male affectional relationship. (Author/WI)

  11. Male Depression: Understanding the Issues

    Science.gov (United States)

    Diseases and Conditions Depression (major depressive disorder) Male depression is a serious medical condition, but many men try to ignore it or refuse treatment. Learn the signs and symptoms — and what to do. By Mayo Clinic Staff Do you feel irritable, isolated or withdrawn? Do you find yourself working all ...

  12. Male parentage in army ants

    DEFF Research Database (Denmark)

    Kronauer, Daniel J C; Schöning, Caspar; Boomsma, Jacobus J

    2006-01-01

    of active research in insect sociobiology. Here we present microsatellite data for 176 males from eight colonies of the African army ant Dorylus (Anomma) molestus. Comparison with worker genotypes and inferred queen genotypes from the same colonies show that workers do not or at best very rarely reproduce...

  13. Male Reproductive System (For Teens)

    Science.gov (United States)

    ... designed to produce, nourish, and transport either the egg or sperm. Unlike the female, whose sex organs are located ... goat) and contains 46 chromosomes — half from the egg and half from the sperm. The genetic material from the male and female ...

  14. Free radicals and male reproduction.

    Science.gov (United States)

    Agarwal, Ashok; Allamaneni, Shyam S R

    2011-03-01

    Male factor accounts for almost 50% cases of infertility. The exact mechanism of sperm dysfunction is not known in many cases. Extensive research in the last decade has led to the identification of free radicals (reactive oxygen species) as mediators of sperm dysfunction in both specific diagnoses and idiopathic cases of male infertility. Elevated levels of reactive oxygen species are seen in up to 30-80% of men with male infertility. The role of free radicals has been studied extensively in the process of human reproduction. We know now that a certain level of free radicals is necessary for normal sperm function, whereas an excessive level of free radicals can cause detrimental effect on sperm function and subsequent fertilisation and offspring health. Oxidative stress develops when there is an imbalance between generation of free radicals and scavenging capacity of anti-oxidants in reproductive tract. Oxidative stress has been shown to affect both standard semen parameters and fertilising capacity. In addition, high levels of free radicals have been associated with lack of or poor fertility outcome after natural conception or assisted reproduction. Diagnostic techniques to quantify free radicals in infertile patients can assist physicians treating patients with infertility to plan for proper treatment strategies. In vivo anti-oxidants can be used against oxidative stress in male reproductive tract. Supplementation of in vitro anti-oxidants can help prevent the oxidative stress during sperm preparation techniques in assisted reproduction.

  15. Cigarette smoking and male infertility

    Directory of Open Access Journals (Sweden)

    Taymour Mostafa

    2010-07-01

    Full Text Available Numerous studies have identified specific body systems affected by the hazardous effects of the cigarette smoking particularly the respiratory and cardiovascular systems. The effect of smoking on male reproduction has also been studied where semen quality was investigated in different cross-sectional studies including infertile patients with conflicting results. This article aimed to assess the relationship between smoking and male infertility. A review of published articles was carried out, using PubMed, medical subject heading (MSH databases and Scopus engine excluding the effects of smoking outside male infertility. Key words used to assess exposure, outcome, and estimates for the concerned associations were: smoking, semen, male infertility, sperm, humans, and fertility. Most of the reports showed that smoking reduces sperm production, sperm motility, sperm normal forms and sperm fertilising capacity through increased seminal oxidative stress and DNA damage. Few papers reported nonsignificant differences in semen parameters between smokers or non-smokers. It is concluded that although some smokers may not experience reduced fertility, men with marginal semen quality can benefit from quitting smoking.

  16. Male fertility in cystic fibrosis.

    LENUS (Irish Health Repository)

    Chotirmall, S H

    2011-04-05

    Infertility rates among males with cystic fibrosis (CF) approximate 97%. No information is currently available within Ireland determining an understanding of fertility issues and the best methods of information provision to this specialized group. This study aimed to determine understanding and preferred approaches to information provision on fertility issues to Irish CF males. A Descriptive Study utilizing prospective coded questionnaires was mailed to a male CF cohort (n=50). Sections included demographics, fertility knowledge & investigation. Response rate was 16\\/50 (32%). All were aware that CF affected their fertility. More than two-thirds (n=11) were able to provide explanations whilst only one-third (n=5) provided the correct explanation. Significant numbers stated thoughts of marriage and a future family. Half have discussed fertility with a healthcare professional (HCP). Mean age of discussion was 21.9 years. One third preferred an earlier discussion. The commonest first source for information was written material which was also the preferred source. Three-quarters requested further information preferring again, written material. Significant gaps in sex education of Irish CF males exist. Discussion should be initiated by HCPs and centre-directed written material devised to address deficiencies.

  17. Male Osteoporosis in the Elderly

    OpenAIRE

    Patrizia D’Amelio; Giovanni Carlo Isaia

    2015-01-01

    Osteoporosis is now recognized as an important public health problem in elderly men as fragility fractures are complicated by increased morbidity, mortality, and social costs. This review comprises an overview of recent findings in pathophysiology, diagnosis, and treatment of male osteoporosis, with particular regard to the old population.

  18. Discussion the Theory of "Shi's Twelve Word Life Cultivation Skill"%“施氏十二字养生功”的基础理论探讨

    Institute of Scientific and Technical Information of China (English)

    胡志俊; 王世伟; 施杞; 叶秀兰; 唐占英

    2011-01-01

    目的:探讨施氏十二字养生功理论渊源及作用原理.方法:通过发掘古代医学文献对导引的论述并结合现代医学理论来探讨施氏十二字养生功的作用机理.结果:施氏十二字养生功是在中医传统导引理论指导下通过长期的临床实践创建的养生功,对以颈椎病为主的骨退行性病变引起的疼痛不适等有良好疗效.结论:施氏十二字养生功是防治颈椎病有效方法之一.%Objective: Discussion the origin of "Shi's twelve word life cultivation skill " theory and principle. Methods: To explore the ancient medical literature through the discussion on the guidance and combined with modern medical theory of health work Discussion the theory of "Shi's twelve word life cultivation skill" and it's mechanism. Results: "Shi's twelve word life cultivation skill" is guided in the theory of traditional Chinese medicine under the guidance of clinical practice through long-term work to create the health of the cervical degenerative bone disease mainly caused such pain and discomfort have a good effect. Conclusion: "Shi's twelve-word life-cultivation skill" is an effective method for prevention and treatment of cervical spondylosis.

  19. Flies from L.A., The Sequel: A further twelve new species of Megaselia (Diptera: Phoridae) from the BioSCAN Project in Los Angeles (California, USA)

    OpenAIRE

    Hartop, Emily; Brown, Brian; Disney,R. Henry

    2016-01-01

    Presented are continued results from the BioSCAN Project, an urban biodiversity study sampling primarily from private backyards in Los Angeles, California (USA). Presented are continued results from the BioSCAN Project, an urban biodiversity study sampling primarily from private backyards in Los Angeles, California (USA). Twelve new species of Megaselia (Diptera: Phoridae) are described: M. baileyae, M. friedrichae, M. gonzalezorum, M. joanneae, M. losangelensis, M. phyllissunae, M. p...

  20. The Twelve Promises of Alcoholics Anonymous: psychometric measure validation and mediational testing as a 12-step specific mechanism of behavior change.

    Science.gov (United States)

    Kelly, John F; Greene, M Claire

    2013-12-01

    Empirical support for the recovery utility of 12-step mutual-help organizations (MHOs) has led to increased investigation of how such organizations confer benefit. The Twelve Promises of Alcoholics Anonymous (AA) feature prominently in 12-step philosophy and culture and are one of the few documented explications of the cognitive, affective, and behavioral benefits that members might accrue. This study investigated the psychometric properties of a measure of AA's Twelve Promises and examined whether it mediated the effect of 12-step participation on abstinence. Young adults (N=302, M age 20.4 [1.6], range 18-25; 27% female; 95% White) enrolled in an addiction treatment effectiveness study completed assessments at intake and 3-, 6-, and 12-months post treatment including a 26-item, Twelve Promises Scale (TPS). Factor analyses examined the TPS' psychometrics and lagged mediational analyses tested the TPS as a mechanism of behavior change. Robust principal axis factoring extraction with Varimax rotation revealed a 2-factor solution explaining 45-58% of the variance across three administrations ("Psychological Wellbeing"=26-39%; "Freedom from Craving=17-21%); internal consistency was high (alpha=.83-.93). Both factors were found to increase in relation to greater 12-step participation, but significant mediation was found only for the Freedom from Craving factor explaining 21-34% of the effect of 12-step participation in increasing abstinence. The TPS shows potential as a conceptually relevant, and psychometrically sound measure and may be useful in helping elucidate the extent to which the Twelve Promises emerge as an independent benefit of 12-step participation and/or explain SUD remission and recovery. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  1. Immunophenotyping of male breast cancer.

    Science.gov (United States)

    Kornegoor, Robert; Verschuur-Maes, Anoek H J; Buerger, Horst; Hogenes, Marieke C; de Bruin, Peter C; Oudejans, Joost J; Hinrichs, Bernd; van Diest, Paul J

    2012-12-01

    Male breast cancer is a rare disease, and knowledge of carcinogenesis is limited. Conflicting results, based on small series, have been reported for clinically relevant biomarkers. One hundred and thirty-four cases of male breast cancer were immunohistochemically stained on tissue microarrays for oestrogen receptor (ER), progesterone receptor (PR), androgen receptor, human epidermal growth factor receptor 2 (HER2), BRST2, cyclin D1, bcl-2, p53, p16, p21, Ki67, cytokeratin (CK) 5/6, CK14, and epidermal growth factor receptor. Data were correlated with clinicopathological features and patient outcome. High mitotic count and high grade were correlated with high Ki67, HER2 amplification/overexpression, p53 accumulation, high p21 expression, low PR expression, and low bcl-2 expression. PR negativity (P=0.009) and p53 accumulation (P=0.042) were correlated with decreased 5-year survival and were independent markers for patient outcome in Cox regression. In unsupervised hierarchical clustering, four groups were identified that were correlated with distinctive clinicopathological features. The hormone negative/ER-positive/high-grade cluster was significantly associated with decreased survival (P=0.011) and was an independent prognostic factor in Cox regression. Several tissue biomarkers are associated with an aggressive phenotype in male breast cancer. PR and p53 are the most promising individual prognostic markers. On the basis of immunophenotype, four distinctive and prognostically relevant male breast cancer groups were identified, indicating that protein expression profiling may be clinically useful in male breast cancer. © 2012 Blackwell Publishing Limited.

  2. Ultra pressure liquid chromatography-negative electrospray ionization mass spectrometry determination of twelve halobenzoquinones at ng/L levels in drinking water.

    Science.gov (United States)

    Huang, Rongfu; Wang, Wei; Qian, Yichao; Boyd, Jessica M; Zhao, Yuli; Li, Xing-Fang

    2013-05-01

    We report here the characterization of twelve halobenzoquinones (HBQs) using electrospray ionization (ESI) high resolution quadrupole time-of-flight mass spectrometry. The high resolution negative ESI spectra of the twelve HBQs formed two parent ions, [M + H(+) + 2e(-)], and the radical M(-•). The intensities of these two parent ions are dependent on their chemical structures and on instrumental parameters such as the source temperature and flow rate. The characteristic ions of the HBQs were used to develop an ultra pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. At the UPLC flow rate (400 μL/min) and under the optimized ESI conditions, eleven HBQs showed the stable and abundant transitions [M + H(+) + 2e(-)] → X(-) (X(-) representing Cl(-), Br(-), or I(-)), while dibromo-dimethyl-benzoquinone (DBDMBQ) showed only the transition of M(-•) → Br(-). The UPLC efficiently separates all HBQs including some HBQ isomers, while the MS/MS offers exquisite limits of detection (LODs) at subng/mL levels for all HBQs except DBDMBQ. Combined with solid phase extraction (SPE), the method LOD is down to ng/L. The results from analysis of authentic samples demonstrated that the SPE-UPLC-MS/MS method is reliable, fast, and sensitive for the identification and quantification of the twelve HBQs in drinking water.

  3. Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol

    Institute of Scientific and Technical Information of China (English)

    Xuan Lu; Zelin Chen; Yi Guo; Liang Gao; Liyuan Jiang; Zhongzheng Li; Jianqiao Fang

    2013-01-01

    A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.

  4. Effect of Blood-letting Puncture at Twelve Well-Points of Hand on Consciousness and Heart Rate in Patients with Apoplexy

    Institute of Scientific and Technical Information of China (English)

    Guo Yi; Wang Xiuyun; Xu Tangping; Dai Zhihua; Li Yunchen

    2005-01-01

    Objective: To observe the effect of blood-letting puncture at Twelve Well-Points of Hand on consciousness and heart rate in patients with early apoplexy. Method: Under observation were patients with disturbance of consciousness within 3 days after the apoplectic seizure. The patients were divided into a large injury team, a moderate injury team and a mild injury team. Each team was again randomly divided into a puncture group and a control group, with routine treatment in both groups but bloodletting puncture only in the puncture group. Quantitative changes in consciousness, blood pressure and heart rate of the patients were observed. Result: Blood-letting puncture at Twelve Well-Points of Hand can improve the consciousness and raise the systolic pressure in patients of the mild injury team, and accelerate the heart rate in all the patients in the puncture group. Conclusion: Blood-letting puncture at Twelve Well-Points of Hand can improve the consciousness of patients with brain injury in small area.

  5. A Comparison of the Twelve Core Values of Thai People Defined by the Head of the National Council for Peace and Order (NCPO) Found in Thai Private and Public University Students

    Science.gov (United States)

    Ngammuk, Patariya

    2016-01-01

    This study aims to examine the twelve core values of Thai people found in Thai university students. The twelve values consist of the following attributes: 1.Upholding the nation, the religions and the Monarchy 2. Being honest, sacrificial and patient with positive attitude for the common good of the public 3. Being grateful to the parents,…

  6. Review of the Spirobolida on Madagascar, with descriptions of twelve new genera, including three genera of 'fire millipedes' (Diplopoda

    Directory of Open Access Journals (Sweden)

    Thomas Wesener

    2009-09-01

    Full Text Available Twelve new genera and 37 new species of Spirobolida are described: Corallobolus cruentus gen. n., sp. n., Sanguinobolus maculosus gen. n., sp. n., Colossobolus semicyclus gen. n., sp. n., C. oblongopedus sp. n., C. giganteus sp. n., C. minor sp. n., C. litoralis sp. n., C. aculeatus sp. n., C. pseudoaculeatus sp. n., Zehntnerobolus gen. n., Flagellobolus pauliani gen. n., sp. n., Riotintobolus mandenensis gen. n., sp. n., R. minutus sp. n., R. aridus sp. n., R. anomalus sp. n., Pseudocentrobolus aureus gen. n., sp. n., P. vohibasiensis sp. n., Granitobolus endemicus gen. n., sp. n., G. andohahelensis sp. n., Caprobolus andringitra gen. n., sp. n., Alluviobolus laticlavius gen. n., sp. n., A. tsimelahy sp. n., A. antanosy sp. n., Ostinobolus rufus gen. n., sp. n., O. stellaris sp. n., O. montanus sp. n., O. subterraneus sp. n., and Hylekobolus brachiosauroides gen. n., sp. n., H. rufus sp. n., H. griseus sp. n., H. albicollaris sp. n., H. goodmani sp. n., H. montanus sp. n., H. analavelona sp. n., H. latifrons sp. n., H. andasibensis sp. n., H. marojejy sp. n., H. anjanaharibe sp. n. All genera and species are endemic to Madagascar. Hylekobolus belongs to the family Spirobolellidae, while all other Malagasy genera of Spirobolida belong to the Pachybolidae. Among them, only Zehntnerobolus gen. n. is based on a previously described species: Spirobolus rubripes de Saussure & Zehntner, 1897, whereas the remaining 11 new genera altogether contain (a total of 37 new species. Three of the new genera are large-bodied “fire millipedes” (>100 mm long with striking red/black colour patterns. The new discoveries increase the number of endemic Malagasy genera of Spirobolida more than fivefold (from 3 to 15. The number of endemic species recorded from Madagascar has more than doubled (to 61. Body length of the new species varies greatly (between 23 and 170 mm. Keys to all Malagasy Spirobolida families, genera, as well as the newly described species

  7. Angiogenesis in male breast cancer

    Directory of Open Access Journals (Sweden)

    Kanthan Rani

    2005-03-01

    Full Text Available Abstract Background Male breast cancer is a rare but aggressive and devastating disease. This disease presents at a later stage and in a more advanced fashion than its female counterpart. The immunophenotype also appears to be distinct when compared to female breast cancer. Angiogenesis plays a permissive role in the development of a solid tumor and provides an avenue for nutrient exchange and waste removal. Recent scrutiny of angiogenesis in female breast cancer has shown it to be of significant prognostic value. It was hypothesized that this holds true in invasive ductal carcinoma of the male breast. In the context of male breast cancer, we investigated the relationship of survival and other clinico-pathological variables to the microvascular density of the tumor tissue. Methods Seventy-five cases of primary male breast cancer were identified using the records of the Saskatchewan Cancer Agency over a period of 26 years. Forty-seven cases of invasive ductal carcinoma of the male breast had formalin-fixed paraffin-embedded tissue blocks that were suitable for this study. All cases were reviewed. Immunohistochemical staining was performed for the angiogenic markers (cluster designations 31 (CD31, 34 (CD34 and 105 (CD105, von Willebrand factor (VWF, and vascular endothelial growth factor (VEGF. Microvascular density (MVD was determined using average, centre, and highest microvessel counts (AMC, CMC, and HMC, respectively. Statistical analyses compared differences in the distribution of survival times and times to relapse between levels of MVD, tumor size, node status and age at diagnosis. In addition, MVD values were compared within each marker, between each marker, and were also compared to clinico-pathological data. Results Advanced age and tumor size were related to shorter survival times. There were no statistically significant differences in distributions of survival times and times to relapse between levels of MVD variables. There was no

  8. Graduating Black Males: A Generic Qualitative Study

    Science.gov (United States)

    Bell, Edward E.

    2014-01-01

    Black males face a difficult educational battle. Across America, graduation statistics for Black males are sobering. The purpose of this study was to explore why Black males drop out of school and to examine the current employment status of the study participants. The research took place in rural North Carolina. Fifteen Black American male high…

  9. The physiology and timing of male puberty

    DEFF Research Database (Denmark)

    Tinggaard, Jeanette; Mieritz, Mikkel Grunnet; Sørensen, Kaspar

    2012-01-01

    To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing.......To describe available markers of male puberty, discuss associations between adiposity and pubertal timing and to review recent evidence of a possible secular trend in male pubertal timing....

  10. Development of Japonica Male Sterile Lines Integrating Cytoplasmic Male Sterility and Photosensitive Genic Male Sterility

    Institute of Scientific and Technical Information of China (English)

    WANG Shou-hai; DU Shi-yun; WANG De-zheng; LI Cheng-quan

    2005-01-01

    It has been previously established that the BT type of cytoplasmic male sterility (CMS) is induced by high temperatures,while photosensitive genic male sterility (PGMS) seed sets by low temperatures induce. In the current study, we have bred photosensitive cytoplasmic male sterility (PCMS) lines (2308SA and 2310SA) by crossing the CMS line with the PGMS japonica line with maintainer genes. The sterility of PCMS japonica was consequently controlled by two groups of male sterile genes resulting from the integration of PGMS and CMS genes. The results on plant fertility, at different sowing times, were as follows: (a) Under conditions of natural long-day photoperiod and at temperatures above 35℃, the PGMS gene regulated PCMS japonica sterility - the higher the temperature, the lower the pollen fertility. However, bagged seed sets of PCMS japonica, not exposed to high temperatures, induced the CMS seed set. (b) Exposure to long-day photoperiod and temperature conditions between 35℃ and the critical sterility inducing temperature of PGMS resulted in both PGMS and CMS gene controlled sterility of PCMS japonica, which exhibited stable characteristics. (c) When exposed to critical sterility inducing temperatures or short-day photoperiod and daily high temperatures below 32℃, the BT type of the CMS gene regulated PCMS sterility. Under these conditions, the PGMS gene rendered male sterility insusceptible to occasional cool summer days when this PCMS line, adopted for hybrid seed production, develops into panicle differentiation stage.The present study also investigated the fertility restoration, seed production and combining ability of PCMS japonica so as to optimize its use.

  11. Conspicuous Coloration in Males of the Damselfly Nehalennia irene (Zygoptera: Coenagrionidae: Do Males Signal Their Unprofitability to Other Males?

    Directory of Open Access Journals (Sweden)

    Christopher D Beatty

    Full Text Available In damselflies, sexual colour dimorphism is commonly explained as a consequence of selection on traits that increase male attractiveness to females. However, while many species in the damselfly family Coenagrionidae (Insecta: Odonata are sexually dimorphic, the males do not engage in displays, and male competition for mates resembles a "scramble". An alternative explanation for the sexual differences in coloration within these species is that sexual dimorphism has evolved as a sex-related warning signal, with males signalling their uprofitability as mates to other males, thereby avoiding harassment from conspecifics. We evaluated an underlying assumption of the theory that male-male harassment rate is influenced by colour by comparing harassment of males of the species Nehalennia irene that had been painted to make them appear: (i similar to an unaltered male (blue, (ii different from a male (orange and (iii more similar to a female (black. When caged together we found that blue-painted males experienced significantly lower harassment than black-painted males. When unpainted males were caged with each type of painted male we found that blue-painted males and the unpainted males housed in the same cages experienced lower rates of harassment than males housed in cages where some males were painted black, suggesting that a single, reliable signal of unprofitability may benefit the individuals that carry it. While our results do not in themselves demonstrate that sexual colour dimorphism originally evolved as an intra-specific warning signal, they do show that harassment is influenced by coloration, and that such selection could conceivably maintain male coloration as a warning signal.

  12. Epigenetics, spermatogenesis and male infertility.

    Science.gov (United States)

    Rajender, Singh; Avery, Kelsey; Agarwal, Ashok

    2011-01-01

    Epigenetic modifications characterized by DNA methylation, histone modifications, and chromatin remodeling are important regulators in a number of biological processes, including spermatogenesis. Several genes in the testes are regulated through epigenetic mechanisms, indicating a direct influence of epigenetic mechanisms on the process of spermatogenesis. In the present article, we have provided a comprehensive review of the epigenetic processes in the testes, correlation of epigenetic aberrations with male infertility, impact of environmental factors on the epigenome and male fertility, and significance of epigenetic changes/aberrations in assisted reproduction. The literature review suggested a significant impact of epigenetic aberrations (epimutations) on spermatogenesis, and this could lead to male infertility. Epimutations (often hypermethylation) in several genes, namely MTHFR, PAX8, NTF3, SFN, HRAS, JHM2DA, IGF2, H19, RASGRF1, GTL2, PLAG1, D1RAS3, MEST, KCNQ1, LIT1, and SNRPN, have been reported in association with poor semen parameters or male infertility. Environmental toxins/drugs may affect fertility via epigenetic modifications. For example, 5-aza-2'-deoxycytidine, an anticancer agent, causes a decrease in global DNA methylation that leads to altered sperm morphology, decreased sperm motility, decreased fertilization capacity, and decreased embryo survival. Similarly, Endocrine disruptors, such as methoxychlor (an estrogenic pesticide) and vinclozolin (an anti-androgenic fungicide) have been found by experiments on animals to affect epigenetic modifications that may cause spermatogenic defects in subsequent generations. Assisted reproduction procedures that have been considered rather safe, are now being implicated in inducing epigenetic changes that could affect fertility in subsequent generations. Techniques such as intracytoplasmic sperm injection (ICSI) and round spermatid injection (ROSI) may increase the incidence of imprinting disorders and

  13. Measuring male infertility: epidemiological aspects

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    Pasqualotto Fábio Firmbach

    2003-01-01

    Full Text Available Evidence suggests that human semen quality may have been deteriorating in recent years. Most of the evidence is retrospective, based on analysis of data sets collected for other purposes. Measures of male infertility are needed if we want to monitor the biological capacity for males to reproduce over time or between different populations. We also need these measures in analytical epidemiology if we want to identify risk indicators, risk factors, or even causes of an impaired male fecundity-that is, the male component in the biological ability to reproduce. The most direct evaluation of fecundity is to measure the time it takes to conceive. Since the time of conception may be missed in the case of an early abortion, time to get pregnant is often measured as the time it takes to obtain a conception that survives until a clinically recognized pregnancy or even a pregnancy that ends with a live born child occurs. A prolonged time required to produce pregnancy may therefore be due to a failure to conceive or a failure to maintain a pregnancy until clinical recognition. Studies that focus on quantitative changes in fecundity (that does not cause sterility should in principle be possible in a pregnancy sample. The most important limitation in fertility studies is that the design requires equal persistency in trying to become pregnant and rather similar fertility desires and family planning methods in the groups to be compared. This design is probably achievable in exposure studies that make comparisons with reasonable comparable groups concerning social conditions and use of contraceptive methods.

  14. PHYSIOLOGICAL ASSESSMENT OF MALE ALCOHOLISM

    OpenAIRE

    Chaudhury, S.; Das, S. K.; Mishra, B.S.; Ukil, B.; Bhardwaj, P.; Bhardwaj, R; Dinker, N.L.

    2002-01-01

    In 100 consecutive male inpatients with alcohol dependence and an equal number of age, sex, occupation and regional background matched controls, the value ofgamma-glutamyl transpeptidase (GGT), serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), mean corpuscular volume (MCV) and serum triglycerides were statistically significantly raised among alcoholics on admission as compared to controls. After five weeks of enforced abstinence in hospital the values...

  15. [Assisted procreation for male indication].

    Science.gov (United States)

    Royère, D

    1993-04-15

    Strategy for male infertility looks like a compromise between diagnosis methods with their efficacy and complexity and treatment with their own risks, cost, efficacy. Infertility duration as well as woman's fertility play a key role for such a strategy. Definitive infertility without any correction (secretory azoospermia) will be proposed for alternate projects. Some situations may benefit from specific therapy (hypogonadotropic hypogonadism, anejaculations or retrograde ejaculation). More frequently male hypofertility is suspected with non specific sperm alterations, then assisted reproductive technologies will be discussed. Intra-cervical way artificial insemination with husband semen may be proposed in case of hypospadias, anejaculation, retrograde ejaculation, small volume ejaculate or self-cryostored semen, however negative post-coital test, positive crossed penetration test and positive post-insemination test need to be confirmed. Intrauterine way enhance fertilizing probability by discarding cervical step. It will be justified in case of negative post-coital test as well as crossed penetration test except that sperm preparation allowed to inseminate 500,000 to 1 million motile spermatozoa. Both rigorous monitoring and synchronism between insemination and ovulation enhance the efficacy of IU AIH which allowed a two to four fold increase in the pregnancy rate on a total of six cycles. In vitro fertilization for male factor represent around 15% of all IVF attempts. Both decrease in the fertilization rate and the increase in the pregnancy rate by transfer as compared with tubal factor are well accepted. The fertilization failure remain difficult to explain and need to be cautiously confirmed. Thus IVF represent an actual fertilization test but remain limited by the heterogeneity of parameters under "male factor".(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Male reproductive health and yoga

    OpenAIRE

    Pallav Sengupta; Prasenjit Chaudhuri; Koushik Bhattacharya

    2013-01-01

    Now-a-days reproductive health problems along with infertility in male is very often observed. Various Assisted Reproductive Technologies have been introduced to solve the problem, but common people cannot afford the cost of such procedures. Various ayurvedic and other alternative medicines, along with regular yoga practice are proven to be not only effective to enhance the reproductive health in men to produce a successful pregnancy, but also to regulate sexual desire in men who practice cel...

  17. Male Spine Motion During Coitus

    Science.gov (United States)

    Sidorkewicz, Natalie

    2014-01-01

    Study Design. Repeated measures design. Objective. To describe male spine movement and posture characteristics during coitus and compare these characteristics across 5 common coital positions. Summary of Background Data. Exacerbation of pain during coitus due to coital movements and positions is a prevalent issue reported by low back pain patients. A biomechanical analysis of spine movements and postures during coitus has never been conducted. Methods. Ten healthy males and females engaged in coitus in the following preselected positions and variations: QUADRUPED, MISSIONARY, and SIDELYING. An optoelectronic motion capture system was used to measure 3-dimensional lumbar spine angles that were normalized to upright standing. To determine whether each coital position had distinct spine kinematic profiles, separate univariate general linear models, followed by Tukey's honestly significant difference post hoc analysis were used. The presentation of coital positions was randomized. Results. Both variations of QUADRUPED, mQUAD1 and mQUAD2, were found to have a significantly higher cycle speed than mSIDE (P = 0.043 and P = 0.034, respectively), mMISS1 (P = 0.003 and P = 0.002, respectively), and mMISS2 (P = 0.001 and P spine movement varied depending on the coital position; however, across all positions, the majority of the range of motion used was in flexion. Based on range of motion, the least-to-most recommended positions for a male flexion-intolerant patient are mSIDE, mMISS2, mQUAD2, mMISS1, and mQUAD1. Conclusion. Initial recommendations—which include specific coital positions to avoid, movement strategies, and role of the partner—were developed for male patients whose low back pain is exacerbated by specific motions and postures. Level of Evidence: N/A PMID:25208042

  18. Genetic aspects of male infertility

    Directory of Open Access Journals (Sweden)

    Bartosz Witczak

    2015-01-01

    Full Text Available Currently, infertility affects up to 140 million people worldwide. It is considered that the male factor is responsible for nearly a half of problems in obtaining pregnancy. Increasingly, infertility treatment clinics, as well as standard examinations, also offer genetic tests in the diagnostics of the male infertility factor, such as: karyotype analysis, detection of Y chromosome microdeletions, and examination of the chromosome composition of sperm by the fluorescent in situ hybridisation method (FISH. Genetic factors, defined to date, which cover both chromosomal aberrations and monogenic disorders, are responsible for approximately 10–15% of cases of male infertility. Usually, their phenotypic manifestations are disorders in spermatogenesis, structural changes in the genital organs (e.g. reduced size of the testicles, or sperm dysfunction. Molecular studies intensively carried out in the area of diagnostics and treatment of infertility indicate an increasingly large number of relationships between genetic factors and fertility; however, many genes related with human fertility still remain unidentified.

  19. Chromosomal disorders and male infertility

    Institute of Scientific and Technical Information of China (English)

    Gary L Harton; Helen G Tempest

    2012-01-01

    infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family.Despite this,the molecular and genetic factors underlying the cause of infertility remain largely undiscovered.Nevertheless,more and more genetic factors associated with infertility are being identified.This review will focus on our current understanding of the chromosomal basis of male infertility specifically:chromosomal aneuploidy,structural and numerical karyotype abnormalities and Y chromosomal microdeletions.Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans.Aneuploidy is predominantly maternal in origin,but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts.Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm.Our current understanding of how sperm aneuploidy translates to embryo aneuploidy will be reviewed,as well as the application of preimplantation genetic diagnosis (PGD) in such cases.Clinical recommendations where possible will be made,as well as discussion of the use of emerging array technology in PGD and its potential applications in male infertility.

  20. Male factor infertility and ART

    Institute of Scientific and Technical Information of China (English)

    Herman Tournaye

    2012-01-01

    For years,the management and treatment of male factor infertility has been ‘experience’ and not ‘evidence’ based.Although not evidence-based,current clinical practice involves extensive use of assisted reproductive techniques (ART).Where specific treatments are not indicated or have failed,ART have become popular adjunctive treatments for alleviating male factor infertility.According to the limited evidence available,intrauterine insemination (IUI) may be considered as a first-line treatment in a couple in which the female partner has a normal fertility status and at least 1x 106 progressively motile spermatozoa are recovered after sperm preparation.If no pregnancy is achieved after 3-6 cycles of IUI,optimized in vitro fertilization (IVF) can be proposed.When less than 0.5x 106 progressively motile spermatozoa are obtained after seminal fluid processing or sperm are recovered surgically from the testis or epididymis,intracytoplasmic sperm injection (ICSI) should be performed.Although the outcome of no other ART has ever been scrutinized as much before,no large-scale ‘macroproblems’ have as yet been observed after ICSI.Yet,ICSI candidates should be rigorously screened before embarking on IVF or ICSI,and thoroughly informed of the limitations of our knowledge on the hereditary aspects of male infertility and the safety aspects of ART.

  1. Chromosomal disorders and male infertility.

    Science.gov (United States)

    Harton, Gary L; Tempest, Helen G

    2012-01-01

    Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain largely undiscovered. Nevertheless, more and more genetic factors associated with infertility are being identified. This review will focus on our current understanding of the chromosomal basis of male infertility specifically: chromosomal aneuploidy, structural and numerical karyotype abnormalities and Y chromosomal microdeletions. Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans. Aneuploidy is predominantly maternal in origin, but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts. Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm. Our current understanding of how sperm aneuploidy translates to embryo aneuploidy will be reviewed, as well as the application of preimplantation genetic diagnosis (PGD) in such cases. Clinical recommendations where possible will be made, as well as discussion of the use of emerging array technology in PGD and its potential applications in male infertility.

  2. Surgical treatment for male prolactinoma

    Science.gov (United States)

    Song, Yi-Jun; Chen, Mei-Ting; Lian, Wei; Xing, Bing; Yao, Yong; Feng, Ming; Wang, Ren-Zhi

    2017-01-01

    Abstract A total of 184 cases of surgically treated male prolactinoma were analyzed retrospectively to summarize the outcome of this surgical intervention. We analyzed the general characteristics, clinical manifestations, hormone levels, imaging features, preoperative treatments, surgical outcomes, pathology results, and follow-up records for all included patients. The most common clinical manifestations included sexual dysfunction (47.4%), headache (55.9%), and visual disturbance (46.7%). Serum prolactin levels ranged from 150 to 204,952 ng/mL. Tumor size varied from 6 to 70 mm. Pituitary adenomas grew in a parasellar pattern with visual deficits occurring 40.7% of the time. After surgical therapy, 88.6% of patients achieved symptom relief, and 98.4% experienced an immediate postoperative decline in prolactin level. Fifty-seven patients (31.0%) achieved initial remission, and 26 patients (45.6%) experienced recurrence. Hence, our results suggest that in male prolactinoma characterized by a large pituitary diameter and high serum prolactin level, tumor size predicts the degree of gross resection. The prognostic predictors included preoperative tumor growth pattern and Ki-67 index. Citation: Yi-jun S, Mei-ting C, Wei L, Bing X, Yong Y, Ming F, Ren-zhi W. (2016) Surgical treatment for male prolactinoma: a retrospective study of 184 cases PMID:28079813

  3. Meiotic abnormalities in infertile males.

    Science.gov (United States)

    Egozcue, J; Sarrate, Z; Codina-Pascual, M; Egozcue, S; Oliver-Bonet, M; Blanco, J; Navarro, J; Benet, J; Vidal, F

    2005-01-01

    Meiotic anomalies, as reviewed here, are synaptic chromosome abnormalities, limited to germ cells that cannot be detected through the study of the karyotype. Although the importance of synaptic errors has been underestimated for many years, their presence is related to many cases of human male infertility. Synaptic anomalies can be studied by immunostaining of synaptonemal complexes (SCs), but in this case their frequency is probably underestimated due to the phenomenon of synaptic adjustment. They can also be studied in classic meiotic preparations, which, from a clinical point of view, is still the best approach, especially if multiplex fluorescence in situ hybridization is at hand to solve difficult cases. Sperm chromosome FISH studies also provide indirect evidence of their presence. Synaptic anomalies can affect the rate of recombination of all bivalents, produce achiasmate small univalents, partially achiasmate medium-sized or large bivalents, or affect all bivalents in the cell. The frequency is variable, interindividually and intraindividually. The baseline incidence of synaptic anomalies is 6-8%, which may be increased to 17.6% in males with a severe oligozoospermia, and to 27% in normozoospermic males with one or more previous IVF failures. The clinical consequences are the production of abnormal spermatozoa that will produce a higher number of chromosomally abnormal embryos. The indications for a meiotic study in testicular biopsy are provided.

  4. Effect of Soybean on Male Reproductive Physiology in Male Mice

    Directory of Open Access Journals (Sweden)

    M Modaresi

    2011-01-01

    Full Text Available Introduction & Objective: Soybean (Soja hispida Moench is a member of Fabaceae family. It is a species of legume native to East Asia. Soy contains significant amount of all the essential amino acids for humans therefore, is a good source of protein .Soy has an important role in the improvement and treatment of some cancers such as colon, prostate, and breast. The aim of this study was to investigate the effect of soybeans on reproductive system in male mice. Materials & Methods: This experimental study was conducted at Isfahan Payam e Noor University in 2009. In this research, 32 male mice were randomly grouped into four experimental groups. The control group was fed with soy-free basic diet. The experimental groups 1, 2, and 3 were fed with a diet containing 20%, 30% and 50% soy diet respectively.At the end of 9 weeks of treatment, blood samples were collected and serum levels of testosterone, LH and FSH were measured. The collected data was analyzed with SPSS software using one way ANOVA with Dunnett's post test and Duncan test. Results : In the experimental group which received 20% soy diet, the level of testosterone had a meaningful decrease in comparison with the control group (P<0.05, but in the experimental group which received a 50% soy diet, the level of testosterone had a meaningful increase (P<0.05 .The LH level in 30% and 50% groups had a meaningful increase but no significant differences were observed in FSH level & weight of testicles (P<0.05.The number of sperms in all of the treatment regimes had a meaningful decrease (P0.05 Conclusion: Results of this research indicated that the 20, 30, and 50 percent soy diet had a negative effect on the male reproductive system in mice.

  5. Prevalence, causes, and correlates of traumatic dental injuries among seven-to-twelve-year-old school children in Dera Bassi

    Science.gov (United States)

    Dua, Rohini; Sharma, Sunila

    2012-01-01

    Aim: The paper aims to present a study conducted in Dera Bassi, Mohali, India. The purpose of the study was to ascertain the prevalence of traumatic dental injuries (TDI) in children of age group 7-12 years in private schools in Gulabgarh village. Material & Method: Age & sex distribution, etiological factors, risk factors and cause of injury were the parameters taken into consideration. The data collected was processed and analyzed using the SPSS statistical software program. Results: The overall prevalence of dental trauma was 14.5%, amongst the 880 subjects examined, out of which, 63.2% males and 36.4% females were found to be affected. The maxillary central incisor was found to be most commonly affected tooth (43.8%). The most common cause of injury reported was fall during playing (37.5%). Conclusion: Enamel fracture was most prevalent (50%). No risk factor was significantly higher than others; however children with Angle's class II div 1 malocclusion exhibited greater risk factor for traumatic injuries. PMID:22557895

  6. The dynamics of male-male competition in Cardiocondyla obscurior ants.

    Science.gov (United States)

    Cremer, Sylvia; Suefuji, Masaki; Schrempf, Alexandra; Heinze, Jürgen

    2012-06-15

    The outcome of male-male competition can be predicted from the relative fighting qualities of the opponents, which often depend on their age. In insects, freshly emerged and still sexually inactive males are morphologically indistinct from older, sexually active males. These young inactive males may thus be easy targets for older males if they cannot conceal themselves from their attacks. The ant Cardiocondyla obscurior is characterised by lethal fighting between wingless ("ergatoid") males. Here, we analyse for how long young males are defenceless after eclosion, and how early adult males can detect the presence of rival males. We found that old ergatoid males consistently won fights against ergatoid males younger than two days. Old males did not differentiate between different types of unpigmented pupae several days before emergence, but had more frequent contact to ready-to-eclose pupae of female sexuals and winged males than of workers and ergatoid males. In rare cases, old ergatoid males displayed alleviated biting of pigmented ergatoid male pupae shortly before adult eclosion, as well as copulation attempts to dark pupae of female sexuals and winged males. Ergatoid male behaviour may be promoted by a closer similarity of the chemical profile of ready-to-eclose pupae to the profile of adults than that of young pupae several days prior to emergence. Young ergatoid males of C. obscurior would benefit greatly by hiding their identity from older, resident males, as they are highly vulnerable during the first two days of their adult lives. In contrast to the winged males of the same species, which are able to prevent ergatoid male attacks by chemical female mimicry, young ergatoids do not seem to be able to produce a protective chemical profile. Conflicts in male-male competition between ergatoid males of different age thus seem to be resolved in favour of the older males. This might represent selection at the colony level rather than the individual level.

  7. The dynamics of male-male competition in Cardiocondyla obscurior ants

    Directory of Open Access Journals (Sweden)

    Cremer Sylvia

    2012-06-01

    Full Text Available Abstract Background The outcome of male-male competition can be predicted from the relative fighting qualities of the opponents, which often depend on their age. In insects, freshly emerged and still sexually inactive males are morphologically indistinct from older, sexually active males. These young inactive males may thus be easy targets for older males if they cannot conceal themselves from their attacks. The ant Cardiocondyla obscurior is characterised by lethal fighting between wingless (“ergatoid” males. Here, we analyse for how long young males are defenceless after eclosion, and how early adult males can detect the presence of rival males. Results We found that old ergatoid males consistently won fights against ergatoid males younger than two days. Old males did not differentiate between different types of unpigmented pupae several days before emergence, but had more frequent contact to ready-to-eclose pupae of female sexuals and winged males than of workers and ergatoid males. In rare cases, old ergatoid males displayed alleviated biting of pigmented ergatoid male pupae shortly before adult eclosion, as well as copulation attempts to dark pupae of female sexuals and winged males. Ergatoid male behaviour may be promoted by a closer similarity of the chemical profile of ready-to-eclose pupae to the profile of adults than that of young pupae several days prior to emergence. Conclusion Young ergatoid males of C. obscurior would benefit greatly by hiding their identity from older, resident males, as they are highly vulnerable during the first two days of their adult lives. In contrast to the winged males of the same species, which are able to prevent ergatoid male attacks by chemical female mimicry, young ergatoids do not seem to be able to produce a protective chemical profile. Conflicts in male-male competition between ergatoid males of different age thus seem to be resolved in favour of the older males. This might represent selection

  8. Effect of Restricted Feeding Times on the Longevity and Serum Biochemistry of Male Sprague-Dawley Rats

    OpenAIRE

    Hiragane, Rumi; Ono, Akifumi

    2003-01-01

    The effect of limiting the daily feeding times on longevity and serum biochemistry was studied in adult male Sprague--Dawley rats. Groups 1H, 6H and 12H received a commercial stock diet for one, six and twelve hours daily, respectively. The control group was fed the same diet ad libitum. The final body weight of group 1H was significantly lower, and longevity was significantly greater than in the other three groups. Group 1H consumed only 67% of the intake of the ad libitum group. After 36 we...

  9. Male-male and male-female aggression may influence mating associations in wild octopuses (Abdopus aculeatus).

    Science.gov (United States)

    Huffard, Christine L; Caldwell, Roy L; Boneka, Farnis

    2010-02-01

    Abdopus aculeatus engages in frequent aggression and copulation, exhibits male mate-choice, and employs multiple mating tactics. Here we draw upon established hypotheses to compare male-male aggression (MMA) and male-female aggression (MFA), as they relate to their mating behavior in the wild. When contesting for females, males appear to balance mate preference (resource value) with perceived chances of winning contests (resource holding potential). Although males spent more time mating with and contesting for large "Adjacent Guarded" females (those occupying a den within arm's reach of a large "Adjacent Guarding" male), they exhibited higher rates of aggression over nonadjacent "Temporarily Guarded" females that may be more accessible. The major determinant of male-male aggressive success was size, and this factor may dictate the expression of conditional mating tactics in males. "Adjacent Guarding" males were the largest and most aggressively successful males, earning the most time copulating with females. They are considered to have the highest resource holding potential (RHP) in MMA. By contrast, in MFA, some larger individuals fled from smaller individuals, indicating that RHP appears to be a function of both size and sex in intersexual aggression. This result suggests variation in aggressiveness, or potential for severe injury-even sexual cannibalism during MFA. Male-female aggression may also be influenced by the sexual nonreceptivity of some individuals, or attempts by both sexes to increase foraging behavior by delaying mate-guarding activity.

  10. Twelve-year experience of radioembolization for colorectal hepatic metastases in 214 patients: survival by era and chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lewandowski, Robert J.; Memon, Khairuddin; Hickey, Ryan; Gates, Vanessa L.; Atassi, Bassel; Vouche, Michael; Atassi, Rohi; Desai, Kush; Hohlastos, Elias; Sato, Kent; Habib, Ali [Robert H. Lurie Comprehensive Cancer Center, Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, IL (United States); Mulcahy, Mary F.; Kircher, Sheetal; Newman, Steven B.; Nimeiri, Halla; Benson, Al B. [Northwestern University, Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL (United States); Marshall, Karen; Williams, Melissa; Salzig, Krystina; Salem, Riad [Robert H. Lurie Comprehensive Cancer Center, Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, IL (United States); Northwestern University, Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL (United States)

    2014-10-15

    The aim of this study was to analyze the safety, treatment characteristics and survival outcomes of Yttrium-90 (Y90) radioembolization for unresectable colorectal carcinoma (CRC) liver metastases refractory to standard of care therapy. A total of 214 patients with CRC metastases were treated with Y90 radioembolization over 12 years. Toxicity was assessed using National Cancer Institute common terminology criteria. Overall survival was analyzed from date of diagnosis of primary cancer, hepatic metastases and from the first Y90. Uni/multivariate analyses were performed. Substratification by era of chemotherapeutics was performed. Most patients were male (60 %) and <65 years old (61 %). Of them, 98 % had been exposed to chemotherapy. Grade 3 lymphocyte, bilirubin, albumin, ALP and AST toxicities were observed in 39 %, 11 %, 10 %, 8 % and 4 % of patients, respectively. Grade 4 lymphocyte and ALP toxicities were observed in 5 % and 3 % of patients, respectively. Median overall survival was 43.0, 34.6, and 10.6 months from date of diagnosis of primary cancer, hepatic metastases and first Y90, respectively. Survival was significantly longer in patients: (1) who received ≤2 cytotoxic drugs (n = 104) than those who received 3 (n = 110) (15.2 vs. 7.5 months, p = 0.0001); and (2) who received no biologic agents (n = 52) compared with those that did (n = 162) (18.6 vs. 9.4 months, p = 0.0001). Multivariate analyses identified ≤2 cytotoxic agents, no exposure to biologics, ECOG 0, tumor burden <25 %, lack of extrahepatic disease and albumin >3 g/dL as independent predictors of survival. In this largest metastatic CRC series published to date, Y90 radioembolization was found to be safe; survival varied by prior therapy. Further studies are required to further refine the role of Y90 in metastatic CRC. (orig.)

  11. Performing/Representing Male Bonds

    OpenAIRE

    Costambeys-Kempczynski, Raphael; Hélie, Claire; Pellerin, Pierre-Antoine

    2013-01-01

    Masculinity, Men, Male In 1993, Michael S. Kimmel published a ground-breaking article entitled “Invisible Masculinity,” which began with a particularly striking opening statement: “American men have no history.” Kimmel argues that even if history books are largely written by men and are about men, they do not deal with the experience of men as men. Thus, for Kimmel, men have no history as “gendered selves” and the effect is to render the multiplicity of masculine identities invisible. Thanks ...

  12. Finasteride-associated male infertility

    OpenAIRE

    Sidney Glina; Paulo Augusto Neves; Ricardo Saade; Nelson Rodrigues Netto Jr; Jonathas Borges Soares; Andrea Giannotti Galuppo

    2004-01-01

    Finasteride is a potent and specific inhibitor of the 5alpha-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of finasteride, especially in young fertile patients, because of its action on testosterone metabolism. This paper describes 3 cases of young patients who had very poor seminal quality during finasteride treatment (1 mg/day), and their semin...

  13. Imaging of male pelvic trauma.

    Science.gov (United States)

    Avery, Laura L; Scheinfeld, Meir H

    2012-11-01

    Prompt imaging plays an important role in the evaluation of male pelvic soft tissue trauma. Using appropriate imaging modalities, with optimization of contrast administration when appropriate, is essential for accurate diagnosis. Traumatic bladder rupture, either extraperitoneal or intraperitoneal, is diagnosed with high accuracy using computed tomography cystography. Suspicion of urethral injury warrants evaluation with retrograde urethrography to evaluate for the presence of injury and injury location. Early identification of laceration of the testicular tunica albuginea is essential. Understanding both normal penile anatomy and the imaging appearance of corpus rupture (as opposed to a hematoma) is imperative for proper diagnosis and management.

  14. Turbinski regulator za male hidroelektrarne

    OpenAIRE

    Bergoč, Primož

    2015-01-01

    V pričujočem delu je predstavljen razvoj turbinskega regulatorja za male hidroelektrarne s sinhronskim generatorjem. Turbinski regulator je pomemben člen vsakega hidro agregata, saj je njegova naloga vzdrževati turbino v želeni delovni točki glede na izbran režim obratovanja z reguliranjem odprtja izvršnih členov. Izvršni členi so lahko vodilnik, gonilnik ali iglasti ventil in odrezač, odvisno od vrste turbine. Algoritem turbinskega regulatorja smo izvedli na programirljivem logičnem krmi...

  15. Male Genitoplasty for Intersex Disorders

    Directory of Open Access Journals (Sweden)

    Shilpa Sharma

    2008-01-01

    Full Text Available Aim. To evaluate surgical procedures adopted for male genitoplasty in intersex disorders. Patients and Methods. Case records of intersex patients undergoing male genitoplasty from Pediatric Intersex clinic were studied. Results. Of 356 intersex cases undergoing urethroplasty from 1989–2007, the hypospadias was penoscrotal (68%, scrotal (17% and perineal (15%. 351 patients underwent chordee correction for mild: moderate: severe chordee in 24 : 136 : 191 cases. Byars flaps were fixed upto the corona in 267 cases. Urethroplasty performed was Theirsch duplay in 335 cases, Snodgrass in 16 cases and Ducketts onlay graft in 5 cases that did not require chordee correction. Age at urethroplasty was 2.5 years—22 years (mean 11.5 years, median—5.6 years. Penoscrotal transposition correction and testicular prosthesis insertion were performed independently. Complications included fistula (45, recurrent fistula (11, stricture (12, baggy urethra (8 and recurrent infection due to persistent vaginal pouch (5. Additional distal urethroplasty was required in 15 patients for previous urethroplasty done upto the corona 5–15 years earlier. Conclusion. Hypospadias in intersex disorders is associated with severe chordee in most cases and requires an early chordee correction to allow phallic growth, staged urethroplasty and multiple surgeries to achieve good cosmetic and functional results.

  16. Male genitoplasty for intersex disorders.

    Science.gov (United States)

    Sharma, Shilpa; K Gupta, Devendra

    2008-01-01

    Aim. To evaluate surgical procedures adopted for male genitoplasty in intersex disorders. Patients and Methods. Case records of intersex patients undergoing male genitoplasty from Pediatric Intersex clinic were studied. Results. Of 356 intersex cases undergoing urethroplasty from 1989-2007, the hypospadias was penoscrotal (68%), scrotal (17%) and perineal (15%). 351 patients underwent chordee correction for mild: moderate: severe chordee in 24 : 136 : 191 cases. Byars flaps were fixed upto the corona in 267 cases. Urethroplasty performed was Theirsch duplay in 335 cases, Snodgrass in 16 cases and Ducketts onlay graft in 5 cases that did not require chordee correction. Age at urethroplasty was 2.5 years-22 years (mean 11.5 years, median-5.6 years). Penoscrotal transposition correction and testicular prosthesis insertion were performed independently. Complications included fistula (45), recurrent fistula (11), stricture (12), baggy urethra (8) and recurrent infection due to persistent vaginal pouch (5). Additional distal urethroplasty was required in 15 patients for previous urethroplasty done upto the corona 5-15 years earlier. Conclusion. Hypospadias in intersex disorders is associated with severe chordee in most cases and requires an early chordee correction to allow phallic growth, staged urethroplasty and multiple surgeries to achieve good cosmetic and functional results.

  17. Genetics of human male infertility.

    Science.gov (United States)

    Poongothai, J; Gopenath, T S; Manonayaki, S

    2009-04-01

    Infertility is defined as a failure to conceive in a couple trying to reproduce for a period of two years without conception. Approximately 15 percent of couples are infertile, and among these couples, male factor infertility accounts for approximately 50 percent of causes. Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is unknown (idiopathic) and could be congenital or acquired. Infertility in men can be diagnosed initially by semen analysis. Seminograms of infertile men may reveal many abnormal conditions, which include azoospermia, oligozoospermia, teratozoospermia, asthenozoospermia, necrospermia and pyospermia. The current estimate is that about 30 percent of men seeking help at the infertility clinic are found to have oligozoospermia or azoospermia of unknown aetiology. Therefore, there is a need to find the cause of infertility. The causes are known in less than half of these cases, out of which genetic or inherited disease and specific abnormalities in the Y chromosome are major factors. About 10-20 percent of males presenting without sperm in the ejaculate carry a deletion of the Y chromosome. This deleted region includes the Azoospermia Factor (AZF) locus, located in the Yq11, which is divided into four recurrently deleted non-overlapping subregions designated as AZFa, AZFb, AZFc and AZFd. Each of these regions may be associated with a particular testicular histology, and several candidate genes have been found within these regions. The Deleted in Azoospermia (DAZ) gene family is reported to be the most frequently deleted AZF candidate gene and is located in the AZFc region. Recently, a partial, novel Y chromosome 1.6-Mb deletion, designated "gr/gr" deletion, has been described specifically in infertile men with varying degrees of spermatogenic failure. The DAZ gene has an autosomal homologue, DAZL (DAZ-Like), on the short arm of the chromosome 3 (3

  18. Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals.

    Science.gov (United States)

    Urbina, Stacie L; Roberts, Michael D; Kephart, Wesley C; Villa, Katelyn B; Santos, Emily N; Olivencia, Alyssa M; Bennett, Haley M; Lara, Marissa D; Foster, Cliffa A; Purpura, Martin; Jäger, Ralf; Taylor, Lem W; Wilborn, Colin D

    2017-02-21

    We examined if 12 weeks of capsaicinoid (CAP) supplementation affected appetite, body composition and metabolic health markers. Seventy seven healthy male and female volunteers (30 ± 1 y, 171.2 ± 9.8 cm, 81.0 ± 2.2 kg, 27.5 ± 0.6 kg/m(2)) were randomly assigned to ingest either low-dose CAP (2 mg/d; L-CAP, n = 27), high-dose CAP (4 mg/d; H-CAP, n = 22) from Capsimax or placebo (corn starch; PLA, n = 28) for 12 weeks. At baseline (0 WK), 6 weeks (6 WK) and 12 weeks (12 WK) waist: hip ratio, body composition via dual energy x-ray absorptiometry (DEXA, 0 WK and 12 WK only), self-reported Calorie intakes, appetite levels via Council on Nutrition Appetite Questionnaire (CNAQ) and serum metabolic health markers (0 WK and 12 WK only) were analyzed. Moreover, an oral glucose tolerance test (OGTT) was administered at 0 WK and 12 WK, and serum glucose and insulin responses were examined 30-120 min post test-drink consumption. Waist: hip ratio significantly decreased in L-CAP from 0 WK to 6 WK (p decreases in serum HDL cholesterol levels from WK0 to WK12. However, supplementation did not affect the insulin response to the administered OGTT and/or other indices of insulin sensitivity. These data suggest that H-CAP supplementation reduces self-reported energy intake after 12 weeks of supplementation, and L-CAP supplementation also reduces waist: hip ratio. Longer-term effects of capsaicinoid supplementation on basal insulin and cholesterol levels warrant further investigation.

  19. FMR-1 CGG transitions in male and female carriers of fragile X

    Energy Technology Data Exchange (ETDEWEB)

    Nolin, S.L.; Lewis, F.A. III; Ye, L.L. [New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY (United States)] [and others

    1994-09-01

    We have conducted a preliminary analysis of the CGG transitions observed among the offspring of fragile X male and female carriers using the PCR method of Brown et al. A strong familial clustering was observed in maternal inheritance of the fragile X chromosome. Fifty-eight premutation females passed their fragile X alleles to mutiple offspring (total 134). Forty-nine of these women had 106 children with the full mutation. Nine mothers (2 in the 60-69 repeat range, 6 in the 80-89 range, 1 in the 90-99 range) had a total of 19 premutation and 3 full mutation children. These data suggest that a premutation carrier with 1 premutation child has a reduced risk for full mutation offspring independent of her CGG repeat size. Familial clustering was also observed in transmitting males. The daughters of transmitting males showed surprisingly little variation in CGG repeat size among each set of daughters. In twelve sibling sets, the daughters were within 10 CGGs of each other, 6 sets were within 11-18 repeats, and one set was within 40 repeats. Taken together, the male and female carrier data support the concept of a sequence or structure within or close to the CGG repeat which influences the expansion of the repeat during its transmission from parent to child. We also found that in transmitting males with > 90 repeats, the repeat was often meiotically unstable. In 5 of these males, 44% (7/16) meioses showed a reduction 2-20 CGGs inherited and all 5 fathers had at least 1 daughter with a size reduction. This finding suggests that repeats > 90 may not be stably transmitted in spermatocytes.

  20. Hypersexual desire in males: are males with paraphilias different from males with paraphilia-related disorders?

    Science.gov (United States)

    Kafka, Martin P; Hennen, John

    2003-10-01

    The assessment of current sexual behavior (fantasies, urges, and activities) and sexual preoccupation (measured in min/day) associated with both conventional (i.e., adult relationship-associated) or unconventional (paraphilia and paraphilia-related) sexual behavior were ascertained from a sample of 120 consecutively evaluated males with paraphilias (PA; n = 88, including sex offender paraphiliacs; n = 60) and paraphilia-related disorders (PRD; n = 32). In addition, an assessment of hypersexual desire, defined as the highest sustained period (at least 6 months minimum duration) of persistently enacted sexual behavior (total sexual outlet/week [TSO] after age 15) was assessed. In almost all measures, the PA and PRD groups were not statistically significantly different. The average PA or PRD reported a mean hypersexual TSO of 11.7 +/- 7.3, a mean age of 21.6 +/- 7.1 years at onset of peak hypersexual behavior, and a mean duration of 6.2 +/- 7.6 years of hypersexual TSO. When the sample was stratified into three subgroups on the basis of the lifetime number of PAs + PRDs as a proxy measure of the severity of sexual impulsivity, the "high" group, with at least 5 lifetime PAs and PRDs, consisted of all paraphilic males, predominantly sex offenders, who self-reported the highest hypersexual desire (14.3 +/- 7.9), the highest current TSO/week (9.9 +/- 8.1), the most current sexual preoccupation (2-4 hr/day), and the highest likelihood of incarceration secondary to paraphilic sex-offending behavior. Although hypersexual desire, a quantitative measure of enacted sexual behaviours, may be a meaningful construct for clinically derived samples, the incidence and prevalence of hypersexual desire in community samples of males with paraphilias and paraphilia-related disorders is unknown.

  1. Aging changes in the male reproductive system

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/004017.htm Aging changes in the male reproductive system To use ... sharing features on this page, please enable JavaScript. Aging changes in the male reproductive system may include ...

  2. Suffering in Silence: The Male Incest Victim.

    Science.gov (United States)

    Nasjleti, Maria

    1980-01-01

    The reasons why boys who are victims of incest remain silent are explored in terms of the special meaning of victimization to males. Males' inability to express helplessness and vulnerability is identified as a major contributing factor. (CM)

  3. Psychobiology of Male Homosexuality: Recent Findings

    OpenAIRE

    Annicchiarico Iseda, Ivan Darío; Universidad Nacional de Colombia

    2009-01-01

    In this paper, empirical and theoretical reports which question the causes of male homosexuality are examined. According to these reports, male homosexuality differs from female homosexuality in some respects. Additionally, evidence favouring the consideration of male homosexuality as a biological condition is shown: there are brain differences between gay men and heterosexual men, there are genetic and perinatal factors associated to male homosexuality, there are cognitive and behavioral dif...

  4. Sperm investment in male meadow voles is affected by the condition of the nearby male conspecifics.

    Science.gov (United States)

    Vaughn, Ashlee A; Delbarco-Trillo, Javier; Ferkin, Michael H

    2008-11-01

    Sperm competition occurs when 2 or more males copulate with a particular female during the same reproductive cycle, and their sperm compete to fertilize the female's available eggs. One strategy that male voles use to assess the risk and intensity of sperm competition involves responding to the presence of scent marks of conspecific males found near a sexually receptive female. Previously, we have shown that if a male vole copulated with a female while he was in the presence of the odors of another male he increased his sperm investment relative to his investment if another male's odors were not present. The aim of the present study was to test the hypothesis that males assess differences in the relative quality of competing males and adjust their sperm investment accordingly. We did so by allowing males to copulate when they were exposed to the scent mark of a 24-h food-deprived male (low-quality male) or the scent mark of a male that was not food deprived (high-quality male). The data indicate that male meadow voles did not increase their sperm investment during copulation when exposed to the scent mark of a food-deprived male but did so when they were exposed to the scent mark of a male that was not food deprived. The results support the hypothesis that male voles are able to adjust sperm investment when they encounter the scent marks of males that differ in quality.

  5. Male Osteoporosis in Our Population

    Directory of Open Access Journals (Sweden)

    Seher Kocaoğlu

    2002-12-01

    Full Text Available Male osteoporosis is encountered as an important problem in clinical medicine in the recent years. Our purpose was to evaluate bone mineral density (BMD of vertebrae (L2-L4 and femur (neck and Wards distributed according to age groups in males who applied to physical therapy and rehabilitation and osteoporosis units. Age, height, weight of the patients were measured. Patients with diseases causing secondary osteoporosis were excluded. Lomber vertebral and femoral scores of 110 patients between ages of 22-87 were measured with Lunar DPX 6956 (DEXA. They were classified as normal, osteopenic and osteoporotic based on WHO criteria. Rate of osteopenia and osteoporosis on the basis of lomber t scores were 55.6% and 11.1% in patients between 20-29 years, 40% and 10% in patients between 30-39 years, 18.2% and 27.3% in patients between 40-49 years, 26.3% and 36.8% in patients between 50-59 years, 40.9% and 27.3% in patients 60-69 years, 33.3% and 23.3% in patients 70-79 years, 14.3% and 14.3% in patients between 80-89 years respectively. Rate of osteopenia and osteoporosis on the basis of femur t scores were 11.1% and 11.1% in patients between 20-29 years, 30% and 10% in patients between 30-39 years, 36.4% and 18.2% in patients between 40-49 years, 63.2% and 15.8% in patients between 50-59 years, 54.5% and 31.8% in patients between 60-69 years, 46.9% and 25% in patients between 70-79 years, 28.6% and 28.6% in patients between 80-89 years. As a conclusion of our study we want to draw attention to age at which a decrease in the bone mineral density of male patients starts, and we suggest that neccessary precautions must be taken.

  6. Value Profiles of Male and Female Entrepreneurs.

    Science.gov (United States)

    Fernald, Lloyd W., Jr.; Solomon, George T.

    1987-01-01

    Comparison of the values of 86 male and 74 female entrepreneurs found males' highest terminal values being pleasure and true friendship while females' highest terminal values were health and self-respect. High instrumental values for males were ambition and broadmindedness; while for females high instrumental values were honesty and…

  7. Synchronous bilateral breast cancer in a male

    Science.gov (United States)

    Rubio Hernández, María Caridad; Díaz Prado, Yenia Ivet; Pérez, Suanly Rodríguez; Díaz, Ronald Rodríguez; Aleaga, Zaili Gutiérrez

    2013-01-01

    Male breast cancer, which represents only 1% of all breast cancers, is occasionally associated with a family history of breast cancer. Sporadic male breast cancers presenting with another primary breast cancer are extremely rare. In this article, we report on a 70-year-old male patient with bilateral multifocal and synchronous breast cancer and without a family history of breast cancer. PMID:24319497

  8. Increased strength of the scapular stabilizer and lumbar muscles after twelve weeks of Pilates training using the Reformer machine: A pilot study.

    Science.gov (United States)

    Dos Santos, Núbia Tomain Otoni; Raimundo, Karoline Cipriano; da Silva, Sheila Aparecida; Souza, Lara Andrade; Ferreira, Karoline Carregal; Borges Santo Urbano, Zuleika Ferreira; Gasparini, Andréa Licre Pessina; Bertoncello, Dernival

    2017-01-01

    The aim of this work was to analyze muscle strength in Pilates novices who used the Reformer equipment during twelve training sessions. Twenty-four healthy young female volunteers, who were non-smokers and did not exercise regularly, were split into a control group (mean age 28 ± 4 years and BMI 24.55 ± 3.21 kg/m(2)) and a training group (mean age 29 ± 4 years and BMI 22.69 ± 2.87 kgm(2)). The data were checked for normality using the Kolmogorov-Smirnov test, and were then analyzed using the t-test (p Pilates group). The corresponding values for the lumbar muscles were 53.83 ± 11.66/53.28 ± 11.14 (control group) and 54.75 ± 10.27/64.80 ± 10.20 (Pilates group). After twelve sessions of Pilates with the Reformer equipment, there were improvements in lumbar extensor and scapular stabilizer strength. Several benefits are reported by practitioners of Pilates, but until now, there has been limited scientific evidence of the improvement of strength in the trunk and limbs after application of the technique. Published by Elsevier Ltd.

  9. Mechanisms of action in integrated cognitive-behavioral treatment versus twelve-step facilitation for substance-dependent adults with comorbid major depression.

    Science.gov (United States)

    Glasner-Edwards, Suzette; Tate, Susan R; McQuaid, John R; Cummins, Kevin; Granholm, Eric; Brown, Sandra A

    2007-09-01

    In a population of veterans with co-occurring substance use disorders and concomitant major depressive disorder, the current study compared mechanisms of change and therapeutic effects relevant to both disorders between integrated, dual disorder-specific cognitive behavioral therapy (ICBT) and twelve-step facilitation (TSF). Veterans (N = 148) were given standard pharmacotherapy for depression and were randomly assigned to receive 24 weeks of either TSF or ICBT. Process measures were selected to quantify (1) changes in self-efficacy in ICBT, (2) changes in ability to terminate negative affect in ICBT, (3) twelve-step affiliation (TSA) in TSF, and (4) changes in social support in both conditions. Measures of depression and substance use were administered to all participants before treatment, during treatment, and at the end of treatment. Self-efficacy increased among both TSF and ICBT participants during treatment, whereas self-reported ability to regulate negative affect did not change. Consistent with predictions, TSF participants increased community TSA during treatment, whereas those receiving ICBT reduced TSA. Changes in self-efficacy and TSA were associated with improvement in substance use outcomes at the end of treatment. Hypothesized changes in social support were not supported. Both ICBT and TSF produce improvements in self-efficacy, and these changes are related to substance use outcomes for depressed substance abusers. In TSF, intervention-specific changes in TSA occur during the course of treatment and are related to substance use outcomes.

  10. Foreskin Morbidity in Uncircumcised Males

    DEFF Research Database (Denmark)

    Sneppen, Ida; Thorup, Jørgen

    2016-01-01

    OBJECTIVE: As a consequence of the discussion on whether the health benefits of newborn male circumcision outweigh the risks and the discrepancies in reported figures of complications, we evaluated the incidence and morbidity of foreskin surgery due to medical indications in boys from the Capital...... Region of Denmark in 2014. METHODS: Medical records from all boys operated on the foreskin due to medical reasons in the Capital Region in 2014 were reviewed. Patients with hypospadias, ritual circumcision, and redo-surgery because of complications to nontherapeutic circumcision were excluded. RESULTS......: A total of 181 patients were included. The cumulative risk of undergoing foreskin operation before 18 years of age was 1.7%. Forty patients had histologic verified balanitis xerotica obliterans (BXO) corresponding to a total risk of 0.37% of developing BXO. Mean age at surgery was 10.1 years (range 1...

  11. Muscle dysfunction in male hypogonadism.

    Science.gov (United States)

    Chauhan, A K; Katiyar, B C; Misra, S; Thacker, A K; Singh, N K

    1986-05-01

    Twenty-eight consecutive male patients with primary and secondary hypogonadism (14 each) were evaluated clinically and electrophysiologically for muscle dysfunction. Although generalised muscle weakness was initially reported by only 9 patients, on direct questioning, it was recorded in 19. Objective weakness was found in 13 patients and it involved both the proximal and distal limb muscles. Quantitative electromyography showed evidence of myopathy in the proximal muscle in 25 patients, i.e., reduced MUP duration and amplitude with increased polyphasia in the deltoid and the gluteus maximus. There were no denervation potentials. None of the patients showed clinical neuropathy or NCV abnormalities. Thus, the profile of muscle involvement in hypogonadism closely simulates limb-girdle muscular dystrophy and other endocrine myopathies. The incidence of muscle involvement was higher in secondary hypogonadism. Diminished androgens in primary hypogonadism and diminished growth hormone in the secondary hypogonadism are probably responsible for the myopathy.

  12. Male sexuality with advancing age.

    Science.gov (United States)

    Jung, Andreas; Schill, Wolf-Bernhard

    2004-04-15

    People aged 60 years or older are commonly given the image of grandparents who are sexually rather inactive. However, a high percentage of men over 60 years have sexual desires and are sexually active. Aging men need more time and more direct stimulation of the penis to achieve full erection. The risk of developing erectile dysfunction increases with age. Almost one man in 22 aged 60-69 years without previous erection problems develops erectile dysfunction within 1 year. Hormone replacement therapy is only indicated if testosterone deficiency is combined with the syndrome of the "aging male" and lack of other disorders that are possibly causative and could be treated. For hormone replacement therapy testosterone gel preparations are preferable because they have a short half-time and can be immediately discontinued in the event that a pre-existing occult prostate carcinoma is stimulated.

  13. Male reproductive health and yoga.

    Science.gov (United States)

    Sengupta, Pallav; Chaudhuri, Prasenjit; Bhattacharya, Koushik

    2013-07-01

    Now-a-days reproductive health problems along with infertility in male is very often observed. Various Assisted Reproductive Technologies have been introduced to solve the problem, but common people cannot afford the cost of such procedures. Various ayurvedic and other alternative medicines, along with regular yoga practice are proven to be not only effective to enhance the reproductive health in men to produce a successful pregnancy, but also to regulate sexual desire in men who practice celibacy. Yoga is reported to reduce stress and anxiety, improve autonomic functions by triggering neurohormonal mechanisms by the suppression of sympathetic activity, and even, today, several reports suggested regular yoga practice from childhood is beneficial for reproductive health. In this regard the present review is aimed to provide all the necessary information regarding the effectiveness of yoga practice to have a better reproductive health and to prevent infertility.

  14. Male reproductive health and yoga

    Directory of Open Access Journals (Sweden)

    Pallav Sengupta

    2013-01-01

    Full Text Available Now-a-days reproductive health problems along with infertility in male is very often observed. Various Assisted Reproductive Technologies have been introduced to solve the problem, but common people cannot afford the cost of such procedures. Various ayurvedic and other alternative medicines, along with regular yoga practice are proven to be not only effective to enhance the reproductive health in men to produce a successful pregnancy, but also to regulate sexual desire in men who practice celibacy. Yoga is reported to reduce stress and anxiety, improve autonomic functions by triggering neurohormonal mechanisms by the suppression of sympathetic activity, and even, today, several reports suggested regular yoga practice from childhood is beneficial for reproductive health. In this regard the present review is aimed to provide all the necessary information regarding the effectiveness of yoga practice to have a better reproductive health and to prevent infertility.

  15. Functional rare males in diploid parthenogenetic Artemia.

    Science.gov (United States)

    Maccari, M; Gómez, A; Hontoria, F; Amat, F

    2013-09-01

    Functional males that are produced occasionally in some asexual taxa - called 'rare males' - raise considerable evolutionary interest, as they might be involved in the origin of new parthenogenetic lineages. Diploid parthenogenetic Artemia produce rare males, which may retain the ability to mate with females of related sexual lineages. Here, we (i) describe the frequency of male progeny in populations of diploid parthenogenetic Artemia, (ii) characterize rare males morphologically, (iii) assess their reproductive role, using cross-mating experiments with sexual females of related species from Central Asia and characterize the F1 hybrid offspring viability and (iv) confirm genetically both the identity and functionality of rare males using DNA barcoding and microsatellite loci. Our result suggests that these males may have an evolutionary role through genetic exchange with related sexual species and that diploid parthenogenetic Artemia is a good model system to investigate the evolutionary transitions between sexual species and parthenogenetic strains.

  16. [Brain mechanisms of male sexual function].

    Science.gov (United States)

    Wang, Ying; Dou, Xin; Li, Jun-Fa; Luo, Yan-Lin

    2011-08-01

    In this paper, we reviewed the brain imaging studies of male sexual function in recent years from three aspects: the brain mechanism of normal sexual function, the brain mechanism of sexual dysfunction, and the mechanism of drug therapy for sexual dysfunction. Studies show that the development stages of male sexual activities, such as the excitement phase, plateau phase and orgasm phase, are controlled by different neural networks. The mesodiencephalic transition zone may play an important role in the start up of male ejaculation. There are significant differences between sexual dysfunction males and normal males in activation patterns of the brain in sexual arousal. The medial orbitofrontal cortex and inferior frontal gyrus in the abnormal activation pattern are correlated with sexual dysfunction males in sexual arousal. Serum testosterone and morphine are commonly used drugs for male sexual dysfunction, whose mechanisms are to alter the activating levels of the medial orbitofrontal cortex, insula, claustrum and inferior temporal gyrus.

  17. Transcriptomic Analysis of Differentially Expressed Genes during Flower Organ Development in Genetic Male Sterile and Male Fertile Tagetes erecta by Digital Gene-Expression Profiling.

    Directory of Open Access Journals (Sweden)

    Ye Ai

    Full Text Available Tagetes erecta is an important commercial plant of Asteraceae family. The male sterile (MS and male fertile (MF two-type lines of T. erecta have been utilized in F1 hybrid production for many years, but no report has been made to identify the genes that specify its male sterility that is caused by homeotic conversion of floral organs. In this study, transcriptome assembly and digital gene expression profiling were performed to generate expression profiles of MS and MF plants. A cDNA library was generated from an equal mixture of RNA isolated from MS and MF flower buds (1 mm and 4 mm in diameter. Totally, 87,473,431 clean tags were obtained and assembled into 128,937 transcripts among which 65,857 unigenes were identified with an average length of 1,188 bp. About 52% of unigenes (34,176 were annotated in Nr, Nt, Pfam, KOG/COG, Swiss-Prot, KO (KEGG Ortholog database and/or GO. Taking the above transcriptome as reference, 125 differentially expressed genes were detected in both developmental stages of MS and MF flower buds. MADS-box genes were presumed to be highly related to male sterility in T. erecta based on histological and cytological observations. Twelve MADS-box genes showed significantly different expression levels in flower buds 4 mm in diameter, whereas only one gene expressed significantly different in flower buds 1 mm in diameter between MS and MF plants. This is the first transcriptome analysis in T. erecta and will provide a valuable resource for future genomic studies, especially in flower organ development and/or differentiation.

  18. Transcriptomic Analysis of Differentially Expressed Genes during Flower Organ Development in Genetic Male Sterile and Male Fertile Tagetes erecta by Digital Gene-Expression Profiling.

    Science.gov (United States)

    Ai, Ye; Zhang, Qinghua; Wang, Weining; Zhang, Chunling; Cao, Zhe; Bao, Manzhu; He, Yanhong

    2016-01-01

    Tagetes erecta is an important commercial plant of Asteraceae family. The male sterile (MS) and male fertile (MF) two-type lines of T. erecta have been utilized in F1 hybrid production for many years, but no report has been made to identify the genes that specify its male sterility that is caused by homeotic conversion of floral organs. In this study, transcriptome assembly and digital gene expression profiling were performed to generate expression profiles of MS and MF plants. A cDNA library was generated from an equal mixture of RNA isolated from MS and MF flower buds (1 mm and 4 mm in diameter). Totally, 87,473,431 clean tags were obtained and assembled into 128,937 transcripts among which 65,857 unigenes were identified with an average length of 1,188 bp. About 52% of unigenes (34,176) were annotated in Nr, Nt, Pfam, KOG/COG, Swiss-Prot, KO (KEGG Ortholog database) and/or GO. Taking the above transcriptome as reference, 125 differentially expressed genes were detected in both developmental stages of MS and MF flower buds. MADS-box genes were presumed to be highly related to male sterility in T. erecta based on histological and cytological observations. Twelve MADS-box genes showed significantly different expression levels in flower buds 4 mm in diameter, whereas only one gene expressed significantly different in flower buds 1 mm in diameter between MS and MF plants. This is the first transcriptome analysis in T. erecta and will provide a valuable resource for future genomic studies, especially in flower organ development and/or differentiation.

  19. Male breast cancer: a report of 127 cases at a Moroccan institution

    Directory of Open Access Journals (Sweden)

    Tijami Fouad

    2011-06-01

    Full Text Available Abstract Background Male breast cancer (MBC is a rare disease representing less than 1% of all malignancies in men and only 1% of all incident breast cancers. Our study details clinico-pathological features, treatments and prognostic factors in a large Moroccan cohort. Findings One hundred and twenty-seven patients were collected from 1985 to 2007 at the National Institute of Oncology in Rabat, Morocco. Median age was 62 years and median time for consultation 28 months. The main clinical complaint was a mass beneath the areola in 93, 5% of the cases. Most patients have an advanced disease. Ninety-one percent of tumors were ductal carcinomas. Management consisted especially of radical mastectomy; followed by adjuvant radiotherapy and hormonal therapy with or without chemotherapy. The median of follow-up was 30 months. The evolution has been characterized by local recurrence; in twenty two cases (17% of all patients. Metastasis occurred in 41 cases (32% of all patients. The site of metastasis was the bone in twenty cases; lung in twelve cases; liver in seven case; liver and skin in one case and pleura and skin in one case. Conclusion Male breast cancer has many similarities to breast cancer in women, but there are distinct features that should be appreciated. Future research for better understanding of this disease at national or international level are needed to improve the management and prognosis of male patients.

  20. Risk assessment of K Basin twelve-inch and four-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-06-23

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rate which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. Five four-inch drain valves are located in the north and south loadout pits (NLOP and SLOP), the weasel pit, the technical viewing pit, and the discharge chute pit. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations indicate that only the valve's bonnet and stem are exposed above the basin concrete floor for the twelve-inch drain valve and that much less of the valve's bonnet and stem are exposed above the basin concrete floor for the five four-inch drain valves. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this analysis are to: (1) evaluate the likelihood of damaging the three twelve-inch drain valves located along the north wall of the main basin and the five four-inch drain valves located in the pits from a seismic initiating event, and (2) determine the likelihood of exceeding a specific consequence (initial leak rate) from a damaged valve. The analysis process is a risk-based uncertainty analysis where each variable is modeled using available information and engineering judgement. The uncertainty associated with each variable is represented by a probability distribution (probability density function). Uncertainty exists because of the inherent

  1. Twelve-year proximity relationships in a captive group of western lowland gorillas (Gorilla gorilla gorilla) at the San Diego Wild Animal Park, California, USA.

    Science.gov (United States)

    Nakamichi, Masayuki; Onishi, Kenji; Silldorf, April; Sexton, Peggy

    2014-01-01

    Proximity data were collected in a captive breeding group of gorillas (Gorilla gorilla gorilla) at the San Diego Wild Animal Park (currently called the San Diego Zoo Safari Park) twice a year (spring and fall periods) for over 12 years, by using a convenient method in which individuals less than 5 m from each animal in the group were recorded by scan sampling, approximately once per hour. Immature females from infancy to young adulthood maintained relatively frequent proximity to both their mothers and the silverback male and spent little time alone (no animals within 10 m), with relatively large individual differences. On the other hand, immature males decreased the time spent near their mothers and the silverback male and increased the time spent alone with increasing age. Therefore, sex differences in proximity to mothers and the silverback male became apparent after late juvenility. Some adult females maintained increased frequency of proximity to the silverback male than that by other females over the 12-year period, indicating the presence of long-term, stable proximity relationships between the silverback male and the adult females. Such long-term, stable proximity relationships were also observed among adult females. Some association patterns reported in wild gorillas, such as frequent proximity between adult females with dependent offspring and the silverback male and close relationships between related females, were not observed in the present study. The idiosyncratic or individual factors influencing some association patterns were easily reflected in captive situations.

  2. Cytokinesis in plant male meiosis.

    Science.gov (United States)

    De Storme, Nico; Geelen, Danny

    2013-03-01

    In somatic cell division, cytokinesis is the final step of the cell cycle and physically divides the mother cytoplasm into two daughter cells. In the meiotic cell division, however, pollen mother cells (PMCs) undergo two successive nuclear divisions without an intervening S-phase and consequently generate four haploid daughter nuclei out of one parental cell. In line with this, the physical separation of meiotic nuclei does not follow the conventional cytokinesis pathway, but instead is mediated by alternative processes, including polar-based phragmoplast outgrowth and RMA-mediated cell wall positioning. In this review, we outline the different cytological mechanisms of cell plate formation operating in different types of PMCs and additionally focus on some important features associated with male meiotic cytokinesis, including cytoskeletal dynamics and callose deposition. We also provide an up-to-date overview of the main molecular actors involved in PMC wall formation and additionally highlight some recent advances on the effect of cold stress on meiotic cytokinesis in plants.

  3. Male hypogonadism: Symptoms and treatment

    Directory of Open Access Journals (Sweden)

    Peeyush Kumar

    2010-01-01

    Full Text Available Male hypogonadism is a condition in which the body does not produce enough of the testosterone hormone; the hormone that plays a key role in masculine growth and development during puberty. There is a clear need to increase the awareness of hypogonadism throughout the medical profession, especially in primary care physicians who are usually the first port of call for the patient. Hypogonadism can significantly reduce the quality of life and has resulted in the loss of livelihood and separation of couples, leading to divorce. It is also important for doctors to recognize that testosterone is not just a sex hormone. There is an important research being published to demonstrate that testosterone may have key actions on metabolism, on the vasculature, and on brain function, in addition to its well-known effects on bone and body composition. This article has been used as an introduction for the need to develop sensitive and reliable assays for sex hormones and for symptoms and treatment of hypogonadism.

  4. Apparel Buying Behaviors Of black Males and White Males When Purchasing Men's Business Suits

    OpenAIRE

    Gravely, Terry Maurice

    1999-01-01

    More information is needed to understand the Black male consumer. Although expanding in the past five years, research about the buying behaviors of consumers has tended to avoid males, particularly Black males. Retailers and marketers should understand the immense diversity among consumers if they are to market apparel accurately and successfully. The purpose of this research was to investigate Black males and Whites males to examine if differences in their buying behavior for appar...

  5. Apparel Buying Behaviors of Black Males and White Males When Purchasing Men's Business Suits

    OpenAIRE

    Gravely, Terry Maurice

    1999-01-01

    More information is needed to understand the Black male consumer. Although expanding in the past five years, research about the buying behaviors of consumers has tended to avoid males, particularly Black males. Retailers and marketers should understand the immense diversity among consumers if they are to market apparel accurately and successfully. The purpose of this research was to investigate Black males and Whites males to examine if differences in their buying behavior for appar...

  6. Grooming reciprocity in male Tibetan macaques.

    Science.gov (United States)

    Xia, Dong-Po; Li, Jin-Hua; Garber, Paul A; Matheson, Megan D; Sun, Bing-Hua; Zhu, Yong

    2013-10-01

    In several primate species, adult males are reported to compete for access to reproductive partners as well as forming affiliative and cohesive social bonds based on the exchange of goods or services. We hypothesized that among a broad set of fitness-maximizing strategies, grooming can be used by individual adult males to enhance social relationships through reciprocity and/or through the interchange of grooming for a different but equivalent good or service. We used focal animal sampling and continuously recorded dyadic grooming and agonistic interactions to test a series of predictions regarding male social interactions in a free-ranging group of Tibetan macaques (Macaca thibetana) at Huangshan, China. During the non-mating season or between males of similar rank throughout the year, grooming effort given was matched by grooming effort received. However, lower ranking males groomed higher ranking males at a greater rate and/or for a longer duration during both the mating and non-mating periods. We found that higher ranking males directed less aggression towards males with whom they formed a frequent grooming partnership, indicating that grooming received was interchanged for increased social tolerance. These data suggest that individual male Tibetan macaques employ alternative social strategies associated with grooming reciprocity or interchange depending on dominance rank and rates of aggression, and highlight the importance of both biological markets and grooming reciprocity as behavioral mechanisms used by resident adult males to form and maintain affiliative social bonds.

  7. Inconel 718十二角头螺栓制造工艺技术研究%Study on Manufacturing Technology for Inconel 718 Twelve-Point Bolt

    Institute of Scientific and Technical Information of China (English)

    王玉凤; 刘风雷; 庄宝潼

    2015-01-01

    The material and structure features of Inconel 718 twelve-point bolt are introduced, and key manufacturing technologies, such as hot heading, heat treatment, warm rolling, etc. are analyzed, and optimal technological parameters are obtained. Dimensional in-spection and qualiifcation tests are carried out. The results show that technology designing is rational..%介绍了Inconel 718十二角头螺栓的材料和结构特点,分析了关键制造加工技术,如热镦锻、热处理、滚压螺纹等,确定了合理的工艺参数,并对研制件的尺寸和性能进行了评估,结果表明工艺技术设计合理。

  8. Molecular phylogenetic systematics of twelve species of Acipenseriformes based on mtDNA ND4L -ND4 gene sequence analysis

    Institute of Scientific and Technical Information of China (English)

    张四明; 张亚平; 郑向忠; 陈永久; 邓怀; 汪登强; 危起伟; 张云武; 聂龙; 吴清江

    2000-01-01

    Acipenseriformes is an endangered primitive fish group, which occupies a special place in the history of ideas concerning fish evolution, even in vertebrate evolution. However, the classification and evolution of the fishes have been debated. The mitochondrial DMA (mtDNA) ND4L and partial A7D4 genes were first sequenced in twelve species of the order Acipenseriformes, including endemic Chinese species. The following points were drawn from DNA sequences analysis: (i) the two species of Huso can be ascribed to Acipenser; (ii) A. dabryanus is the mostly closely related to A. sinensis, and most likely the landlocked form of A. sinensis; (iii) genus Acipenser in trans-Pacific region might have a common origin; (iv) mtDNA ND4L and ND4 genes are the ideal genetic markers for phylogenetic analysis of the order Acipenseriformes.

  9. Molecular phylogenetic systematics of twelve species of Acipenseriformes based on mtDNA ND4L -ND4 gene sequence analysis

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Acipenseriformes is an endangered primitive fish group, which occupies a special place in the history of ideas concerning fish evolution, even in vertebrate evolution. However, the classification and evolution of the fishes have been debated. The mitochondrial DNA (mtDNA) ND4L and partial ND4 genes were first sequenced in twelve species of the order Acipenseriformes, including endemic Chinese species. The following points were drawn from DNA sequences analysis: (i) the two species of Huso can be ascribed to Acipenser; (ii) A. dabryanus is the mostly closely related to A. sinensis, and most likely the landlocked form of A. sinensis; (iii) genus Acipenser in trans-Pacific region might have a common origin; (iv) mtDNA ND4L and ND4 genes are the ideal genetic markers for phylogenetic analysis of the order Acipenseriformes.

  10. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation.

    Directory of Open Access Journals (Sweden)

    Joseph Ndunguru

    Full Text Available Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV and Ugandan cassava brown streak virus (UCBSV which are frequently found infecting cassava, one of sub-Saharan Africa's most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production.

  11. Age Distribution of Influenza Like Illness Cases during Post-Pandemic A(H3N2): Comparison with the Twelve Previous Seasons, in France

    Science.gov (United States)

    Turbelin, Clément; Souty, Cécile; Pelat, Camille; Hanslik, Thomas; Sarazin, Marianne; Blanchon, Thierry; Falchi, Alessandra

    2013-01-01

    In France, the 2011–2012 influenza epidemic was characterized by the circulation of antigenically drifted influenza A(H3N2) viruses and by an increased disease severity and mortality among the elderly, with respect to the A(H1N1)pdm09 pandemic and post-pandemic outbreaks. Whether the epidemiology of influenza in France differed between the 2011–2012 epidemic and the previous outbreaks is unclear. Here, we analyse the age distribution of influenza like illness (ILI) cases attended in general practice during the 2011–2012 epidemic, and compare it with that of the twelve previous epidemic seasons. Influenza like illness data were obtained through a nationwide surveillance system based on sentinel general practitioners. Vaccine effectiveness was also estimated. The estimated number of ILI cases attended in general practice during the 2011–2012 was lower than that of the past twelve epidemics. The age distribution was characteristic of previous A(H3N2)-dominated outbreaks: school-age children were relatively spared compared to epidemics (co-)dominated by A(H1N1) and/or B viruses (including the 2009 pandemic and post-pandemic outbreaks), while the proportion of adults over 30 year-old was higher. The estimated vaccine effectiveness (54%, 95% CI (48, 60)) was in the lower range for A(H3N2) epidemics. In conclusion, the age distribution of ILI cases attended in general practice seems to be not different between the A(H3N2) pre-pandemic and post-pandemic epidemics. Future researches including a more important number of ILI epidemics and confirmed virological data of influenza and other respiratory pathogens are necessary to confirm these results. PMID:23755294

  12. In vivo models for male reproductive toxicology.

    Science.gov (United States)

    Tyl, Rochelle W

    2002-05-01

    In Vivo Models for Male Reproductive Toxicology (Rochelle W. Tyl, Research Triangle Institute, Research Triangle Park, North Carolina). Assessment of male reproductive function requires a specific set of evaluations of the various steps in successful mating from sperm production to copulation to fertilization to production of a viable litter. This unit outlines the measurements that are standard for determining the effects of treatment with toxicant on the reproductive capacity of male mice and rats.

  13. Paget disease of the male nipple

    Directory of Open Access Journals (Sweden)

    El Harroudi T

    2010-01-01

    Full Text Available Breast cancer occurring in the mammary gland of men is infrequent. It accounts for 0.8% of all breast cancers, which is less than one per cent of all newly diagnosed male cancers and 0.2% of male cancer deaths. However, Paget disease of the male nipple is extremely rare. We report a single case of Paget disease with infiltrative ductal carcinoma of the breast in a 61-year-old man.

  14. The Epidemiology of Male Breast Cancer.

    Science.gov (United States)

    Ferzoco, Raina M; Ruddy, Kathryn J

    2016-01-01

    Male breast cancer is a rare disease, accounting for only 1% of breast cancer diagnoses in the USA. The current literature suggests that genetic factors including BRCA2 mutations, family history, age, androgen/estrogen imbalance, and environmental exposures may predispose to male breast cancer. In this manuscript, we will review known and possible risk factors for male breast cancer, as well as describe the clinical patterns of the disease.

  15. Sexually Antagonistic Selection in Human Male Homosexuality

    OpenAIRE

    Andrea Camperio Ciani; Paolo Cermelli; Giovanni Zanzotto

    2008-01-01

    Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of h...

  16. Codependency in male and female helping professionals.

    Science.gov (United States)

    Martsolf, D S; Hughes-Hammer, C; Estok, P; Zeller, R A

    1999-04-01

    The purpose of this study is to determine and compare the prevalence of codependency in a group of 77 female and a group of 72 male helping professionals. Relatively low rates of codependency were observed in this sample, and the five-factor structure of the Codependency Assessment Tool (CODAT) was replicated. Males showed slightly higher codependency than females on the total CODAT and on the Hiding Self and Family of Origin Issues subscales. The CODAT was shown to be relevant to both males and females. Further research is needed to determine if a general population of male and female subjects would yield similar results.

  17. A consumer study of entire male pigs

    DEFF Research Database (Denmark)

    Godt, Jannik; Kristensen, Kai; Poulsen, Carsten Stig;

    1996-01-01

    Former studies of the unpleasant odour of meat from certain uncastrated male pigs have been based mainly on evaluations made by trained sensory panellists. This study analyses the effect of the two dominating male pig odour components, skatole and androstenone, on the evaluation of eating quality...... made in-home by consumers, thus bringing the analysis out of the laboratory and into the market place. The vast majority of the population of uncastrated male pigs have low concentrations of skatole and androstenone. The cutlets that were evaluated in this study were selected from uncastrated male pigs...

  18. [Male breast cancer: a challenge for urologists].

    Science.gov (United States)

    Hofer, C; Schmalfeldt, B; Gschwend, J E; Herkommer, K

    2010-09-01

    Male breast cancer (male BC) accounts for Klinefelter syndrome) and a positive family history for breast cancer. About 90% of male BC are invasive ductal carcinomas. Standard treatment for localized cancer is surgical removal. Adjuvant radiation and systemic therapy are the same as in women with breast cancer. Male BC expresses hormone receptors in about 90% of cases; therefore, tamoxifen is a therapeutic option. A future challenge for the urologist or andrologist is to diagnose the disease at an early stage to improve prognosis.

  19. Strategic male mating effort and cryptic male choice in a scorpionfly.

    Science.gov (United States)

    Engqvist, L; Sauer, K P

    2001-04-07

    In animal species with high male mating effort, males often find themselves in a dilemma: by increasing their mating effort, the gain from each copulation increases but simultaneously reduces available resources and, thus, the opportunity for future copulations. Therefore, we expect males to spend less reproductive resources on matings that provide low reproductive potential, thereby saving resources for future copulations, possibly with high-quality females, a sort of cryptic male choice. However, the strength of the trade-off between investment in a current mating and resources available for future matings must not be the same for all males. Males with relatively high mating costs should allocate their limited resources more cautiously than males with more plentiful resources. Here, we examine this prediction in the scorpionfly Panorpa cognata. Prior to copulation, males produce a large salivary mass on which females feed during copulation. We show that the production of larger salivary masses leads to longer copulations. Moreover, the size of the salivary gland and salivary mass increases with increasing male condition. However, males in poor condition make a relatively higher mating investment than males in good condition. We therefore expect male condition to influence cryptic male choice. In accordance with our hypothesis, only males in poor condition choose cryptically, producing larger salivary masses in copulations with females of high fecundity.

  20. The transvestite serpent: why do male garter snakes court (some) other males?

    Science.gov (United States)

    Shine; Harlow; LeMaster; Moore; Mason

    2000-02-01

    In large mating aggregations of red-sided garter snakes, Thamnophis sirtalis parietalis, in Manitoba, male courtship is directed not only to females, but also to other males with female-like skin lipids ('she-males'). We show that 'she-maleness' is an intrinsic property of a male rather than an artefact of lipid transfer from females, and that male-male courtship is very common in the field. She-males were distinctive in terms of appearance (they were heavier than other males and more often covered with mud), behaviour (they were inactive and rarely courted females) and performance (they were slow crawlers, ineffective courters and easily outcompeted by other males in mating trials). 'She-maleness' was not a characteristic of a particular subset of males, as envisaged in previous work; instead, it was a transitory phase that most (perhaps all) male snakes passed through soon after they first emerged from the winter den. Recently emerged males spent their first day or two relatively inactive, while restoring physiological functions (including locomotor performance and courtship ability). Experimental application of female skin lipids on to males dramatically decreased courtship levels of the recipient snakes. Thus, recently emerged males may derive two kinds of benefit from mimicking female skin lipids. First, female mimicry 'switches off' the male's own (energetically expensive) courtship at a time when that courtship would be unproductive. Second, it may disadvantage his rivals by distracting them from females, and increasing their energy expenditure. Copyright 2000 The Association for the Study of Animal Behaviour.

  1. Male-male competition leads to less abundant but more attractive sperm.

    Science.gov (United States)

    Zizzari, Z Valentina; van Straalen, Nico M; Ellers, Jacintha

    2013-01-01

    Males employ complex strategies to optimize their reproductive success when faced with male-male competition; for instance, they can adjust the ejaculate characteristics. In copulating species, a male may also strategically adjust his ejaculate expenditure according to female quality. Quantifying the relative contribution of ejaculate plasticity in male reproductive success is often difficult, especially when females exert postcopulatory cryptic choice. One way to quantify the functional significance of ejaculate plasticity is offered by mating systems in which the reproductive partners do not meet each other during insemination. In the collembolan Orchesella cincta, males deposit their ejaculates (spermatophores) irrespective of the presence of females. We tested whether Orchesella males adjust spermatophore number when exposed to the presence of another male and whether changes in spermatophore production influence female choice. We found that Orchesella males display plasticity in spermatophore allocation. Males decreased the spermatophore number when exposed to a rival male. Moreover, females preferentially took up spermatophores of males that were exposed to a competitor. The reduction in spermatophore number suggests, besides an adaptive response to the risk of ejaculate removal by rival males, an optimization strategy owing to the costs of more attractive spermatophores.

  2. Both male and female identity influence variation in male signalling effort

    Directory of Open Access Journals (Sweden)

    Svensson P Andreas

    2011-08-01

    Full Text Available Abstract Background Male sexual displays play an important role in sexual selection by affecting reproductive success. However, for such displays to be useful for female mate choice, courtship should vary more among than within individual males. In this regard, a potentially important source of within male variation is adjustment of male courtship effort in response to female traits. Accordingly, we set out to dissect sources of variation in male courtship effort in a fish, the desert goby (Chlamydogobius eremius. We did so by designing an experiment that allowed simultaneous estimation of within and between male variation in courtship, while also assessing the importance of the males and females as sources of courtship variation. Results Although males adjusted their courtship depending on the identity of the female (a potentially important source of within-male variation, among-male differences were considerably greater. In addition, male courtship effort towards a pair of females was highly repeatable over a short time frame. Conclusion Despite the plasticity in male courtship effort, courtship displays had the potential to reliably convey information about the male to mate-searching females. Our experiment therefore underscores the importance of addressing the different sources contributing to variation in the expression of sexually-selected traits.

  3. Approaches to male hypogonadism in primary care

    Science.gov (United States)

    Lawrence, Kristi L.; Stewart, Felicia; Larson, Brandi M.

    2017-01-01

    Abstract: Evidence suggests that providers are not adhering to current testosterone replacement therapy guidelines when treating male hypogonadism. Understanding the diagnosis and management of this condition is further complicated by conflicting recommendations among available guidelines. NPs must select and follow the best guideline recommendations available to optimally treat male hypogonadism. PMID:28085783

  4. Male Anorexia Nervosa: A New Focus.

    Science.gov (United States)

    Crosscope-Happel, Cindy; Hutchins, David E.; Getz, Hildy G.; Hayes, Gerald L.

    2000-01-01

    Although anorexia nervosa affects over one million males yearly, it is often misdiagnosed or overlooked by mental health and medical practitioners. This article brings the problem to the forefront and outlines features that are unique to these males. Greater recognition of the disorder can lead to more accurate diagnoses and, subsequently, better…

  5. A high aggression strategy for smaller males.

    Directory of Open Access Journals (Sweden)

    P Andreas Svensson

    Full Text Available Male-male conflict is common among animals, but questions remain as to when, how and by whom aggression should be initiated. Factors that affect agonistic strategies include residency, the value of the contested resource and the fighting ability of the two contestants. We quantified initiation of aggression in a fish, the desert goby, Chlamydogobius eremius, by exposing nest-holding males to a male intruder. The perceived value of the resource (the nest was manipulated by exposing half of the residents to sexually receptive females for two days before the trial. Resident male aggression, however, was unaffected by perceived mating opportunities. It was also unaffected by the absolute and relative size of the intruder. Instead resident aggression was negatively related to resident male size. In particular, smaller residents attacked sooner and with greater intensity compared to larger residents. These results suggest that resident desert goby males used set, rather than conditional, strategies for initiating aggression. If intruders are more likely to flee than retaliate, small males may benefit from attacking intruders before these have had an opportunity to assess the resident and/or the resource.

  6. A review of eating disorders in males

    NARCIS (Netherlands)

    Raevuori, Anu; Keski-Rahkonen, Anna; Hoek, Hans W.

    2014-01-01

    Purpose of review Research in eating disorders in males has been active lately compared to the past. This review aims to provide an overview of the recently published studies of eating disorders in males. Recent findings Publication of the Diagnostic and Statistical Manual of Mental Disorders, 5th e

  7. Looking at the Male Librarian Stereotype.

    Science.gov (United States)

    Dickinson, Thad E.

    2002-01-01

    Discussion of library profession stereotypes focuses on academic male librarians. Topics include the position of the early academic librarians and the environment in which they worked; the beginnings of reference service; women in academic libraries; men in a feminized profession; and current images of male librarians in motion pictures and…

  8. Looking at the Male Librarian Stereotype.

    Science.gov (United States)

    Dickinson, Thad E.

    2002-01-01

    Discussion of library profession stereotypes focuses on academic male librarians. Topics include the position of the early academic librarians and the environment in which they worked; the beginnings of reference service; women in academic libraries; men in a feminized profession; and current images of male librarians in motion pictures and…

  9. A review of eating disorders in males

    NARCIS (Netherlands)

    Raevuori, Anu; Keski-Rahkonen, Anna; Hoek, Hans W.

    2014-01-01

    Purpose of review Research in eating disorders in males has been active lately compared to the past. This review aims to provide an overview of the recently published studies of eating disorders in males. Recent findings Publication of the Diagnostic and Statistical Manual of Mental Disorders, 5th

  10. Male versus Female Attitudes toward Stuttering

    Science.gov (United States)

    St. Louis, Kenneth O.

    2012-01-01

    Purpose: The study investigated the extent to which differences existed between public attitudes of males versus females. Method: One hundred adults, 50 males and 50 females, were chosen at random from each of 50 study samples comprising a total of 3371 respondents in a database archive who had completed the "Public Opinion Survey of Human…

  11. Genotyping and Phenotyping of Male Breast Cancer

    NARCIS (Netherlands)

    Kornegoor, R.

    2012-01-01

    Male breast cancer is a rare disease and most of the knowledge has been extrapolated from females, although these entities are likely different. A better understanding of male breast carcinogenesis is crucial for developing novel targets suitable for personalized treatment. A major problem in studyi

  12. Genotyping and Phenotyping of Male Breast Cancer

    NARCIS (Netherlands)

    Kornegoor, R.

    2012-01-01

    Male breast cancer is a rare disease and most of the knowledge has been extrapolated from females, although these entities are likely different. A better understanding of male breast carcinogenesis is crucial for developing novel targets suitable for personalized treatment. A major problem in

  13. Male versus Female Attitudes toward Stuttering

    Science.gov (United States)

    St. Louis, Kenneth O.

    2012-01-01

    Purpose: The study investigated the extent to which differences existed between public attitudes of males versus females. Method: One hundred adults, 50 males and 50 females, were chosen at random from each of 50 study samples comprising a total of 3371 respondents in a database archive who had completed the "Public Opinion Survey of Human…

  14. Conditional monogyny: female quality predicts male faithfulness

    Directory of Open Access Journals (Sweden)

    Welke Klaas W

    2012-04-01

    Full Text Available Abstract Introduction Male monogyny in the absence of paternal investment is arguably one of the most puzzling mating systems. Recent evidence suggests that males of monogynous species adjust their life-history and their mating decision to shifting spatial and temporal selection regimes. In the cannibalistic wasp spider Argiope bruennichi males can be either monogynous or mate with a maximum of two females. We studied factors underlying male mating decisions in a natural population over a whole mating season. We documented all matings and categorized the males into single-mated and double-mated monogynous as well as bigynous males. Results We found that all categories were continuously present with relatively stable frequencies despite changes in the operational sex ratio. Males were more likely monogynous when copulating with relatively heavy and old females and otherwise bigynous. Conclusion Our results imply that males make conditional mating decisions based on the quality of the first female they encounter but do not adjust their mating tactic to the local selection regime.

  15. Characteristics Related to Female & Male Leaders

    Science.gov (United States)

    Richardson, Agnes M.

    2004-01-01

    The following research investigated gender and the leadership role and determined if there are differences in leadership styles, behaviors, traits, and characteristics between female leaders and male leaders. Literature suggests there are specific gender leadership differences between males and females in leadership styles, behaviors, traits, and…

  16. Characteristics of Male Homosexual College Students

    Science.gov (United States)

    Fromhart, Michael V.

    1971-01-01

    A limited comparative study of undergraduate homosexual males and control males were compared on referral source, therapy referral, academic interest and achievement, ordinal position, perceived relationship with parents, and personality adjustment as measured by the MMPI. Several differences were found and implications for treatment were…

  17. Career Development of Black Males: Case Studies.

    Science.gov (United States)

    Chung, Y. Barry; Baskin, Monica L.; Case, Andrew B.

    1999-01-01

    Case studies of six black males explored background, school and work experiences, and career issues. These themes emerged: fathers' financial support and role modeling influenced career development; other male role models affected aspirations; social, especially parental support for education and careers influenced decision making; and racism…

  18. Male reproductive health after childhood cancer

    DEFF Research Database (Denmark)

    Lähteenmäki, P M; Arola, M; Suominen, J

    2008-01-01

    Twenty-five male patients were investigated to elucidate the correlation of semen parameters and other related parameters in the assessment of spermatogenesis after childhood cancer treatment.......Twenty-five male patients were investigated to elucidate the correlation of semen parameters and other related parameters in the assessment of spermatogenesis after childhood cancer treatment....

  19. Rogue Males: Sex Differences in Psychology Students

    Science.gov (United States)

    Sander, Paul; Sanders, Lalage

    2006-01-01

    Introduction: This paper reports a preliminary study into the commitment and academic confidence of male students in undergraduate psychology, prompted by our own observations of the performance of male students and the literature on sex differences in education. Method: Using an analytical survey, level 1 psychology students at a new university…

  20. Male skin care: shaving and moisturization needs.

    Science.gov (United States)

    Oblong, John E

    2012-01-01

    Historically, most cosmetic and medical cosmetic research has been focused on the female consumer. Advancements in the development of grooming instruments as well as changing consumer habits and attitudes toward male cosmetic skin care needs support the need to develop a deeper understanding of male skin biology and how that can be used to improve the quality of life relative to societal interactions. Male skin biology has been found to have unique properties that are distinct from females and have a significant impact on the way males groom and maintain their overall appearance. Research to date has found that male skin has a different response profile to such environmental insults as UV, heat, and stress that is based not on just differences in cosmetic or dermatological product usage but also on underlying biological differences. These differences are discussed with the implications to a broader understanding of male facial skin care needs that spans from daily grooming practices to overall health status that impacts higher incidence rate of skin cancer among males. This highlights that male skin care has a holistic need to ensure proper grooming and sunscreen moisturizer usage.

  1. Young Adult Literature for Young Adult Males.

    Science.gov (United States)

    Gill, Sam D.

    1999-01-01

    Argues that young adult literature can play a significant role in the emotional and mental health of an adolescent as well as help young males become more literate. Offers a 19-item annotated list of young adult novels with male protagonists, sorted by themes: nature and adventure stories, sports stories, genre stories, historical stories, and…

  2. Male Teacher Shortage: Black Teachers' Perspectives

    Science.gov (United States)

    Martino, Wayne; Rezai-Rashti, Goli M.

    2010-01-01

    In this paper the authors draw on the perspectives of black teachers to provide a more nuanced analysis of male teacher shortage. Interviews with two Caribbean teachers in Toronto, Canada, are employed to illuminate the limits of an explanatory framework that foregrounds the singularity of gender as a basis for advocating male teachers as role…

  3. Communities for and with Black Male Students

    Science.gov (United States)

    Jett, Christopher C.; Stinson, David W.; Williams, Brian A.

    2015-01-01

    The social and educational status of black male youth in the United States has been receiving increasing attention. In February 2014, President Barack Obama announced a new national initiative--My Brother's Keeper--for helping black boys and male youth or, to speak more generally, boys and young men of color, to "stay on track; providing the…

  4. Why do Adolescent Girls Idolize Male Celebrities?

    Science.gov (United States)

    Engle, Yuna; Kasser, Tim

    2005-01-01

    Girls often idolize male celebrities, but this phenomenon has been studied little. The authors therefore assessed celebrity idolization among 142 junior high school girls and found that girls who strongly idolized a male celebrity had more experience dating, reported secure and preoccupied attachments to same-age boys, and were rated higher in…

  5. [Mechanisms of electromagnetic radiation damaging male reproduction].

    Science.gov (United States)

    Xue, Lei; Chen, Hao-Yu; Wang, Shui-Ming

    2012-08-01

    More and more evidence from over 50 years of researches on the effects of electromagnetic radiation on male reproduction show that a certain dose of electromagnetic radiation obviously damages male reproduction, particularly the structure and function of spermatogenic cells. The mechanisms of the injury may be associated with energy dysmetabolism, lipid peroxidation, abnormal expressions of apoptosis-related genes and proteins, and DNA damage.

  6. Influence of pesticides on male fertility.

    NARCIS (Netherlands)

    Bretveld, R.W.; Brouwers, M.; Ebisch, I.M.W.; Roeleveld, N.

    2007-01-01

    Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these

  7. Twelve lectures on structural dynamics

    CERN Document Server

    Preumont, André

    2013-01-01

    This text addresses the modeling of vibrating systems with the perspective of finding the model of minimum complexity which accounts for the physics of the phenomena at play. The first half of the book (Ch.1-6) deals with the dynamics of discrete and continuous mechanical systems; the classical approach emphasizes the use of Lagrange's equations. The second half of the book (Ch.7-12) deals with more advanced topics, rarely encountered in the existing literature: seismic excitation, random vibration (including fatigue), rotor dynamics, vibration isolation and dynamic vibration absorbers; the final chapter is an introduction to active control of vibrations. The first part of this text may be used as a one semester course for 3rd year students in Mechanical, Aerospace or Civil Engineering. The second part of the text is intended for graduate classes. A set of problems is provided at the end of every chapter. The author has a 35 years experience in various aspects of Structural dynamics, both in industry (nuclea...

  8. Family Textbooks Twelve Years Later

    Science.gov (United States)

    Glenn, Norval D.

    2009-01-01

    In 1996 the author conducted an intensive study of twenty current family textbooks published in the United States, the results of which appeared in an academic journal article and a nonacademic report in 1997. The study included practical "functionalist" marriage and family textbooks and more academic sociology of the family books; these…

  9. The Twelve Days of Shengdan

    Institute of Scientific and Technical Information of China (English)

    JENNIFER; JETT

    2008-01-01

    On the first day of Christmas,China gaveto me A bird that can say ni hao A partridge in a pear tree has nothing on a caged bird that will greet me in Chinese as I pass by—although I worry that one day I’ll try to engage the bird in conversation and find out it speaks better Chinese than I do.

  10. Ocean acidification changes the male fitness landscape

    Science.gov (United States)

    Campbell, Anna L.; Levitan, Don R.; Hosken, David J.; Lewis, Ceri

    2016-01-01

    Sperm competition is extremely common in many ecologically important marine taxa. Ocean acidification (OA) is driving rapid changes to the marine environments in which freely spawned sperm operate, yet the consequences of OA on sperm performance are poorly understood in the context of sperm competition. Here, we investigated the impacts of OA (+1000 μatm pCO2) on sperm competitiveness for the sea urchin Paracentrotus lividus. Males with faster sperm had greater competitive fertilisation success in both seawater conditions. Similarly, males with more motile sperm had greater sperm competitiveness, but only under current pCO2 levels. Under OA the strength of this association was significantly reduced and there were male sperm performance rank changes under OA, such that the best males in current conditions are not necessarily best under OA. Therefore OA will likely change the male fitness landscape, providing a mechanism by which environmental change alters the genetic landscape of marine species. PMID:27531458

  11. Male Infertility and Its Causes in Human

    Directory of Open Access Journals (Sweden)

    Toshinobu Miyamoto

    2012-01-01

    Full Text Available Infertility is one of the most serious social problems facing advanced nations. In general, approximate half of all cases of infertility are caused by factors related to the male partner. To date, various treatments have been developed for male infertility and are steadily producing results. However, there is no effective treatment for patients with nonobstructive azoospermia, in which there is an absence of mature sperm in the testes. Although evidence suggests that many patients with male infertility have a genetic predisposition to the condition, the cause has not been elucidated in the vast majority of cases. This paper discusses the environmental factors considered likely to be involved in male infertility and the genes that have been clearly shown to be involved in male infertility in humans, including our recent findings.

  12. Relevance of genetic investigation in male infertility.

    Science.gov (United States)

    Asero, P; Calogero, A E; Condorelli, R A; Mongioi', L; Vicari, E; Lanzafame, F; Crisci, R; La Vignera, S

    2014-05-01

    Genetic causes can be directly responsible for various clinical conditions of male infertility and spermatogenic impairment. With the increased use of assisted reproduction technologies our understanding of genetic basis of male infertility has large implications not only for understanding the causes of infertility but also in determining the prognosis and management of such couples. For these reasons, the genetic investigations represent today an essential and useful tool in the treatment of male infertility. Several evidences are available for the clinical practice regarding the diagnosis; however, there are less information relative to the treatment of the genetic causes of male infertility. Focus of this review is to discuss the main and more common genetic causes of male infertility to better direct the genetics investigation in the treatment of spermatogenic impairment.

  13. Ocean acidification changes the male fitness landscape

    Science.gov (United States)

    Campbell, Anna L.; Levitan, Don R.; Hosken, David J.; Lewis, Ceri

    2016-08-01

    Sperm competition is extremely common in many ecologically important marine taxa. Ocean acidification (OA) is driving rapid changes to the marine environments in which freely spawned sperm operate, yet the consequences of OA on sperm performance are poorly understood in the context of sperm competition. Here, we investigated the impacts of OA (+1000 μatm pCO2) on sperm competitiveness for the sea urchin Paracentrotus lividus. Males with faster sperm had greater competitive fertilisation success in both seawater conditions. Similarly, males with more motile sperm had greater sperm competitiveness, but only under current pCO2 levels. Under OA the strength of this association was significantly reduced and there were male sperm performance rank changes under OA, such that the best males in current conditions are not necessarily best under OA. Therefore OA will likely change the male fitness landscape, providing a mechanism by which environmental change alters the genetic landscape of marine species.

  14. Mucinous carcinoma in a male breast

    Directory of Open Access Journals (Sweden)

    Roopak Aggarwal

    2011-01-01

    Full Text Available Male breast cancer is rare as compared to female counterpart. Pure mucinous carcinoma is an extremely rare histological subtype representing less than 1% of male breast cancers. So far very few cases of pure mucinous carcinoma of male breast have been reported in the literature, most of which were diagnosed after surgical resection. Fine-needle aspiration cytology is a well-established procedure for the evaluation of female breast masses but the diagnosis of malignancy in aspirates from male breast masses is rare. We herein present one case of mucinous carcinoma of breast in a 75-year-old male diagnosed by fine-needle aspiration and confirmed by histopathology. After a follow-up of 12 months the patient is free of any recurrence or metastasis.

  15. Male-male competition, female mate choice and their interaction: determining total sexual selection

    National Research Council Canada - National Science Library

    Hunt, John; Breuker, Casper J; Sadowski, Jennifer A; Moore, Allen J

    2009-01-01

    .... We first show how a quantitative partitioning and examination of sexual selection mechanisms can inform by identifying illustrative studies that describe both male-male competition and female mate...

  16. Sneaker Males Affect Fighter Male Body Size and Sexual Size Dimorphism in Salmon.

    Science.gov (United States)

    Weir, Laura K; Kindsvater, Holly K; Young, Kyle A; Reynolds, John D

    2016-08-01

    Large male body size is typically favored by directional sexual selection through competition for mates. However, alternative male life-history phenotypes, such as "sneakers," should decrease the strength of sexual selection acting on body size of large "fighter" males. We tested this prediction with salmon species; in southern populations, where sneakers are common, fighter males should be smaller than in northern populations, where sneakers are rare, leading to geographical clines in sexual size dimorphism (SSD). Consistent with our prediction, fighter male body size and SSD (fighter male∶female size) increase with latitude in species with sneaker males (Atlantic salmon Salmo salar and masu salmon Oncorhynchus masou) but not in species without sneakers (chum salmon Oncorhynchus keta and pink salmon Oncorhynchus gorbuscha). This is the first evidence that sneaker males affect SSD across populations and species, and it suggests that alternative male mating strategies may shape the evolution of body size.

  17. Male size composition affects male reproductive variance in Atlantic cod Gadus morhua L. spawning aggregations

    DEFF Research Database (Denmark)

    Bekkevold, Dorte

    2006-01-01

    Estimates of Atlantic cod Gadus morhua reproductive success, determined using experimental spawning groups and genetic paternity assignment of offspring, showed that within-group variance in male size correlated positively with the degree of male mating skew, predicting a decrease in male...... reproductive skew with decreasing size variation among males under natural conditions. (c) 2006 The Author Journal compilation (c) 2006 The Fisheries Society of the British Isles...

  18. Evaluation of twelve maize (Zea mays L. cultivars for silage Avaliação de doze cultivares de milho (Zea mays L. para silagem

    Directory of Open Access Journals (Sweden)

    Maria Celina Jorge Leme

    2010-12-01

    Full Text Available The experiment was conducted to evaluate the agronomic characteristics and chemical composition of different maize cultivars for ensiling of the plant. Twelve maize cultivar were analyzed in a completely randomized block design, with three block, twelve treatments and three replication. The plot with three lines of six meters long and spacing of 0.8 m were used in all trials. The cycle of the plants of the planting to harvest varied from 105 to 114 days. The height average differed among (P 0.05 for ear by plant number (0.9 to 1.1, dry matter (33.2 to 38.2 %, ether extract (1.9 to 2.5 % and neutral detergent fiber (49.1 to 56.2 %. The dry matter production differed (P O experimento foi realizado com o objetivo de avaliar as características agronômicas e químico-bromatológica de diferentes cultivares de milho para ensilagem. Foram avaliados doze cultivares de milho em delineamento experimental em blocos casualizados, com três blocos, 12 tratamentos e três repetições. As parcelas foram constituídas por três linhas de seis metros de comprimento e espaçamento de 0,8 m entre linhas. O ciclo das plantas, do plantio à colheita, variou de 105 a 114 dias. A altura média diferiu entre os cultivares (P 0,05 entre os cultivares para número de espigas por planta (0,9 a 1,1, teores de matéria seca (33,2 a 38,2 %, de extrato etéreo (1,9 a 2,5 % e de fibra em detergente neutro (49,1 a 56,2 %. A produção de matéria seca diferiu (P < 0,05 entre o cultivar TORK (20,6 t/ha e os cultivares CD-302 (16,4 t/ha e TRAKTOR (15,7 t/ha. O AGN-3150 apresentou o menor teor de fibra em detergente ácido (24,2 % e maior digestibilidade (80,7 %. Todas as cultivares apresentaram características agronômicas e qualitativas adequadas para produção de silagem, destacando-se os cultivares TORK e AGN-3150.

  19. 试述十二律结合四气理论防治五脏疾病%Prevention and Treatment of Five Zang-organs Diseases with Twelve Temperaments Combining with Siqi Theory

    Institute of Scientific and Technical Information of China (English)

    贺海辉; 雷磊; 吴子明

    2013-01-01

    The study and treatment of the music therapy is very popular in Europe and America. While the Chi-nese traditional music therapy is still in the stage of excavation, both the theory and clinical practice are waiting for exploration and development. Through the formation of twelve temperaments and twelve temperaments system, this article discussed the twelve temperaments which reflect the yin and yang of twelve months, and the five in-ternal organs reflect the yin and yang of the four season . The author thinks that the twelve temperaments can pre-vent and treat diseases of five zang-organs, and puts forward the train of thought of prevention and treatment of five zang-organs diseases with twelve temperaments combining with Siqi theory.%目前音乐疗法在欧美的研究和治疗应用非常普遍,而我国中医音乐疗法还处于挖掘整理阶段,无论是基础理论还是临床实践都有待进一步的探索和发展。本文通过论述十二律的形成和十二律吕制度表明十二律反映十二月阴阳,以及五脏通应自然界四时阴阳,认为十二律能够防治五脏疾病,并提出十二律结合四气防治疾病的思路。

  20. Primate Socioecology: New Insights from Males

    Science.gov (United States)

    Kappeler, Peter M.

    Primate males have only recently returned to the center stage of socioecological research. This review surveys new studies that examine variation in the behavior of adult males and their role in social evolution. It is shown that group size, composition, and social behavior are determined not only by resource distribution, predation risk, and other ecological factors, but that life history traits and social factors, especially those related to sexual coercion, can have equally profound consequences for social systems. This general point is illustrated by examining male behavior at three levels: the evolution of permanent associations between males and females, the causes and consequences of variation in the number of males between group-living species, and the determinants of social relationships within and between the sexes. Direct and indirect evidence reviewed in connection with all three questions indicates that the risk of infanticide has been a pervasive force in primate social evolution. Several areas are identified for future research on male life histories that should contribute to a better understanding of male reproductive strategies and corresponding female counterstrategies.

  1. Recognition of competitors by male golden hamsters.

    Science.gov (United States)

    Petrulis, Aras; Weidner, Molly; Johnston, Robert E

    2004-06-01

    Golden hamsters, like many animals, form dominant/subordinate relationships after aggressive encounters. We examined whether behavioral responses by males that won or lost fights would differ toward familiar and unfamiliar male stimulus animals. In Experiment 1, male winners or losers of fights explored an arena containing a confined stimulus animal that was either familiar or novel and had either won or lost a fight. Compared to dominant males, losers spent less time in proximity to stimulus males and investigated them less. Losers also displayed higher levels of stretch-attend postures (indicative of risk assessment) than winners, and they showed more escape and locomotion in response to familiar winners than to unfamiliar winners, indicating recognition of the male that they had lost to. In Experiment 2, losers scent marked less to the odors of a familiar winner than to those of an unfamiliar winner. Thus, male hamsters appear to use familiarity with a former opponent's odors to adaptively regulate their responses to variations in social threat.

  2. Sexually antagonistic selection in human male homosexuality.

    Directory of Open Access Journals (Sweden)

    Andrea Camperio Ciani

    Full Text Available Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness, accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait.

  3. Sexually antagonistic selection in human male homosexuality.

    Science.gov (United States)

    Camperio Ciani, Andrea; Cermelli, Paolo; Zanzotto, Giovanni

    2008-06-18

    Several lines of evidence indicate the existence of genetic factors influencing male homosexuality and bisexuality. In spite of its relatively low frequency, the stable permanence in all human populations of this apparently detrimental trait constitutes a puzzling 'Darwinian paradox'. Furthermore, several studies have pointed out relevant asymmetries in the distribution of both male homosexuality and of female fecundity in the parental lines of homosexual vs. heterosexual males. A number of hypotheses have attempted to give an evolutionary explanation for the long-standing persistence of this trait, and for its asymmetric distribution in family lines; however a satisfactory understanding of the population genetics of male homosexuality is lacking at present. We perform a systematic mathematical analysis of the propagation and equilibrium of the putative genetic factors for male homosexuality in the population, based on the selection equation for one or two diallelic loci and Bayesian statistics for pedigree investigation. We show that only the two-locus genetic model with at least one locus on the X chromosome, and in which gene expression is sexually antagonistic (increasing female fitness but decreasing male fitness), accounts for all known empirical data. Our results help clarify the basic evolutionary dynamics of male homosexuality, establishing this as a clearly ascertained sexually antagonistic human trait.

  4. Male microchimerism in the human female brain.

    Directory of Open Access Journals (Sweden)

    William F N Chan

    Full Text Available In humans, naturally acquired microchimerism has been observed in many tissues and organs. Fetal microchimerism, however, has not been investigated in the human brain. Microchimerism of fetal as well as maternal origin has recently been reported in the mouse brain. In this study, we quantified male DNA in the human female brain as a marker for microchimerism of fetal origin (i.e. acquisition of male DNA by a woman while bearing a male fetus. Targeting the Y-chromosome-specific DYS14 gene, we performed real-time quantitative PCR in autopsied brain from women without clinical or pathologic evidence of neurologic disease (n=26, or women who had Alzheimer's disease (n=33. We report that 63% of the females (37 of 59 tested harbored male microchimerism in the brain. Male microchimerism was present in multiple brain regions. Results also suggested lower prevalence (p=0.03 and concentration (p=0.06 of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain.

  5. Offspring loss after male change in wild siamangs: the importance of abrupt weaning and male care.

    Science.gov (United States)

    Morino, Luca; Borries, Carola

    2017-01-01

    Infanticide by males is assumed to promote permanent male-female associations, although its importance for social monogamy is still debated. We examined the consequences of male membership change in the largest socially monogamous primate, the siamang (Symphalangus syndactylus), a species that also forms polyandrous groups and where males may provide offspring care. We examine (a) the potential risk of infanticide by documenting changes in female-offspring relationships following male change, expecting abrupt weaning; and (b) the potential importance of male care and polyandry for offspring survival. We witnessed four male changes at Way Canguk Field Station (Indonesia) in groups where the youngest offspring was estimated to be about 2 years of age. We quantified aspects of mother-offspring relationships (interindividual distance, body contact, and nipple contact) and estimated the proportion of time being carried during travel (August 2007-April 2009). In the two groups into which new males immigrated, offspring were weaned abruptly, suggesting infanticide by males as a potential risk. Even though no attacks on infants by males were witnessed, both infants disappeared shortly after the male change. Another infant disappeared after its main carrier (a male) emigrated. Conversely, in a group where the resident subordinate male replaced the dominant male, the offspring experienced no change in care and survived the transition. These findings suggest that male immigration in hylobatids increases mortality risk for infants, emphasize the importance of offspring care, and cast doubts on prior classifications of 2-year-old siamangs as independently traveling individuals. © 2016 Wiley Periodicals, Inc.

  6. Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates.

    Science.gov (United States)

    McManus, I C; Keeling, A; Paice, E

    2004-08-18

    The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style.

  7. Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L. Endemic Ecotypes of Southern Italy before and after Cooking

    Directory of Open Access Journals (Sweden)

    Maria Neve Ombra

    2016-01-01

    Full Text Available Beans are important dietary components with versatile health benefits. We analysed the extracts of twelve ecotypes of Phaseolus vulgaris in order to determine their phenolic profiles, antioxidant activity, and the in vitro antiproliferative activity. Ultra-performance liquid chromatography with diode array detector (UPLC-DAD admitted us to detect and quantify some known polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol. The antioxidant activity (AA ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg necessary to inhibit the activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH radical by 50% (EC50. The extracts, except those obtained from the nonpigmented samples, were capable of inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2 cells, human breast cancer cells MCF-7, and A549 NSCLC cell line. Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally. Qualitative and quantitative differences in phenolic composition between the groups of beans influenced the biological activities; on the other hand, we did not find significant differences on the biological activities within the same variety, before and after cooking.

  8. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial

    Science.gov (United States)

    Carroll, Kathleen M.; Nich, Charla; Shi, Julia M.; Eagan, Dorothy; Ball, Samuel A.

    2012-01-01

    Background Cocaine use remains a major problem within methadone maintenance programs. Disulfiram’s efficacy in reducing cocaine use has been demonstrated in several trials, but its relative efficacy among individuals who use versus abstain from alcohol remains unclear Treatment approaches which seek to enhance substance users’ involvement in self-help activities (Twelve Step Facilitation, TSF) have been associated with better outcomes among alcohol and cocaine users, but have rarely been evaluated among methadone-maintained cocaine-opioid users. Methods We conducted a randomized, placebo controlled, double blind (for medication condition), factorial (2×2) trial with 4 treatment conditions: Disulfiram plus TSF, disulfiram plus standard counseling only, placebo plus TSF, and placebo plus standard counseling in the context of a community-based methadone maintenance program. Participants (N=112) received either disulfiram (250 mg/d) or placebo in conjunction with daily methadone maintenance. Results Assignment to TSF was associated with less cocaine use throughout treatment and a higher number of cocaine-negative urines. While there were no significant main effects of disulfiram versus placebo, individuals without an alcohol use disorder demonstrated greater reductions in cocaine use over time when assigned to disulfiram. Conclusions TSF appears feasible in this methadone maintenance program and was associated with modest reductions in cocaine use, an often intractable problem in this setting. Support for the efficacy of disulfiram was weaker, as it appeared effective only for those without a current alcohol use disorder for this sample. PMID:22695473

  9. Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds.

    Science.gov (United States)

    Sevane, N; Armstrong, E; Wiener, P; Pong Wong, R; Dunner, S

    2014-07-01

    Current customers' demands focus on the nutritional and sensory quality of cattle meat. Candidate gene approach allows identification of genetic polymorphisms that have a measurable effect on traits of interest. The aim of this work is to identify new molecular markers for beef production through an association study using 27 candidate genes and 314 purebred bulls from 11 European cattle breeds. Twelve genes were found associated with different lipid and meat quality traits, and among these stand out the considerable effect of CAST on fatness score, CGGBP1 on growth traits, HSPB1 on the percentage of lauric acid (12:0) and phospholipid docosahexaenoic acid (DHA 22:6 n - 3), RORA on the ratio of light absorption (K) to light scattering (S) (K/S), and TNFA on lightness (L*). Most of these traits are related to post-mortem muscle biochemical changes, which are key factors controlling meat quality and consumers' acceptance. Also, the variations produced on muscle fatty acid profiles, such as those of AANAT, CRH, CSN3, HSPB1, and TNFA, give insights into the genetic networks controlling these complex traits and the possibility of future improvement of meat nutritional quality.

  10. Twelve weeks of BodyBalance® training improved balance and functional task performance in middle-aged and older adults

    Directory of Open Access Journals (Sweden)

    Nicholson VP

    2014-11-01

    Full Text Available Vaughan P Nicholson, Mark R McKean, Brendan J Burkett School of Health and Sport Sciences, University of the Sunshine Coast, Sunshine Coast, QLD, Australia Purpose: The purpose of the study was to evaluate the effect of BodyBalance® training on balance, functional task performance, fear of falling, and health-related quality of life in adults aged over 55 years.Participants and methods: A total of 28 healthy, active adults aged 66±5 years completed the randomized controlled trial. Balance, functional task performance, fear of falling, and self-reported quality of life were assessed at baseline and after 12 weeks. Participants either undertook two sessions of BodyBalance per week for 12 weeks (n=15 or continued with their normal activities (n=13.Results: Significant group-by-time interactions were found for the timed up and go (P=0.038, 30-second chair stand (P=0.037, and mediolateral center-of-pressure range in narrow stance with eyes closed (P=0.017. There were no significant effects on fear of falling or self-reported quality of life.Conclusion: Twelve weeks of BodyBalance training is effective at improving certain balance and functional based tasks in healthy older adults. Keywords: postural control, yoga, tai chi, center of pressure, exercise

  11. Theory of the “New Music” Expressionism Based on Schoenberg’ s Twelve-Tone Music%论“新音乐”的表现主义

    Institute of Scientific and Technical Information of China (English)

    林健丹

    2014-01-01

    The Western music of the 20th century, due to the social change, the influence of the economic recovery and cultural ideological trend, produced extremely complex and changeful music form and cultural form.This article, through the innovation of the 20th century Western new music composing techniques, taking Schoenberg and expressionist music representative of twelve-tone music as an example, discusses the“new music” under the influence of the ideological trend of expressionist music, as well as the“tradition” in the leading position of expressionist music.%20世纪的西方音乐,由于受到社会变动、经济复苏和文化思潮的影响,产生了极其复杂多变的音乐形式和文化形态。本文将借20世纪西方新音乐作曲技法的创新,并以表现主义音乐代表人物勋伯格的十二音音乐为例进行分析,论述了“新音乐”思潮影响下的表现主义音乐,以及“反传统”思想在表现主义音乐中的主导地位。

  12. Barley husk carbon as the fiber coating for the solid-phase microextraction of twelve pesticides in vegetables prior to gas chromatography-mass spectrometric detection.

    Science.gov (United States)

    Liang, Weiqian; Wang, Juntao; Zang, Xiaohuan; Dong, Wenhuan; Wang, Chun; Wang, Zhi

    2017-03-31

    In this work, a barley husk biomaterial was successfully carbonized by hydrothermal method. The carbon had a high specific surface area and good stability. It was coated onto a stainless steel wire through sol-gel technique to prepare a solid-phase microextraction fiber for the extraction of trace levels of twelve pesticides (tsumacide, fenobucarb, indoxacarb, diethofencarb, thimet, terbufos, malathion, thiamethoxam, imidacloprid, buprofezin, acetamiprid, thiamethoxam) from vegetable samples prior to gas chromatography-mass spectrometric (GC-MS) detection. The main experimental parameters that could influence the extraction efficiency such as extraction time, extraction temperature, sample pH, sample salinity, stirring rate, desorption temperature and desorption time, were investigated. Under the optimized conditions, the linearity was observed in the range of 0.2-75.0μgkg(-1) for tomato samples, and 0.3-60.0μgkg(-1) for cucumber samples, with the correlation coefficients (r) ranging from 0.9959 to 0.9983. The limits of detection of the method were 0.01-0.05μgkg(-1) for tomato samples, and 0.03-0.10μgkg(-1) for cucumber samples. The recoveries of the analytes for the method from spiked samples were in the range of 76%-104%, and the precision, expressed as the relative standard deviations, was less than 12%. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Discussion on the Rhetoric of Libretto in Twelve Muqam%浅谈《十二木卡姆》唱词的修辞性

    Institute of Scientific and Technical Information of China (English)

    李芸

    2015-01-01

    木卡姆语言的佳妙,除了配合歌腔旋律的演唱外,还表现出了其驾驭文字的艺术手法。论文从不同木卡姆剧本中搜寻出最常用的修辞格,并例举若干例子分别说明这些修辞格在作品中的作用及其相关的问题,试图从修辞立场来研读木卡姆语言的艺术成果。%Twelve Muqam’s libretto showed the writing art, excepting with the song melody singing cavity. We searched most commonly used figures of speech from the script of a different Maqam, and cited a number of examples to illustrate the role of rhetorical devices in his works and their associated problems. We will try to study Muqam language art achievements from from the perspective of rhetoric.

  14. Transfer of eleven species of the genus Burkholderia to the genus Paraburkholderia and proposal of Caballeronia gen. nov. to accommodate twelve species of the genera Burkholderia and Paraburkholderia.

    Science.gov (United States)

    Dobritsa, Anatoly P; Samadpour, Mansour

    2016-08-01

    It has been proposed to split the genus Burkholderia into two genera according to phylogenetic clustering: (1) a genus retaining this name and consisting mainly of animal and plant pathogens and (2) the genus Paraburkholderia including so-called environmental bacteria. The latter genus name has been validly published recently. During the period between the effective and valid publications of the genus name Paraburkholderia, 16 novel species of the genus Burkholderiawere described, but only two of them can be classified as members of this genus based on the emended genus description. Analysis of traits and phylogenetic positions of the other 11 species shows that they belong to the genus Paraburkholderia, and we propose to transfer them to this genus. The reclassified species names are proposed as Paraburkholderia dipogonis comb. nov., Paraburkholderia ginsengiterrae comb. nov., Paraburkholderia humisilvae comb. nov., Paraburkholderia insulsa comb. nov., Paraburkholderia kirstenboschensis comb. nov., Paraburkholderia metalliresistens comb. nov., Paraburkholderia monticola comb. nov., Paraburkholderia panaciterrae comb. nov., Paraburkholderia rhizosphaerae comb. nov., Paraburkholderia solisilvae comb. nov. and Paraburkholderia susongensis comb. nov. The remaining three species are transferred to the new genus Caballeronia gen. nov. proposed to accommodate twelve species of the genera Burkholderia and Paraburkholderia forming a distinctive clade in phylogenetic trees. The new genus members are Caballeronia choica comb. nov., Caballeronia cordobensis comb. nov., Caballeronia glathei comb. nov., Caballeronia grimmiae comb. nov., Caballeronia humi comb. nov., Caballeronia megalochromosomata comb. nov., Caballeronia jiangsuensis comb. nov., Caballeronia sordidicola comb. nov., Caballeronia telluris comb. nov., Caballeronia terrestris comb. nov., Caballeronia udeis comb. nov., and Caballeronia zhejiangensis comb. nov.

  15. Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking.

    Science.gov (United States)

    Ombra, Maria Neve; d'Acierno, Antonio; Nazzaro, Filomena; Riccardi, Riccardo; Spigno, Patrizia; Zaccardelli, Massimo; Pane, Catello; Maione, Mena; Fratianni, Florinda

    2016-01-01

    Beans are important dietary components with versatile health benefits. We analysed the extracts of twelve ecotypes of Phaseolus vulgaris in order to determine their phenolic profiles, antioxidant activity, and the in vitro antiproliferative activity. Ultra-performance liquid chromatography with diode array detector (UPLC-DAD) admitted us to detect and quantify some known polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol. The antioxidant activity (AA) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg necessary to inhibit the activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 50% (EC50). The extracts, except those obtained from the nonpigmented samples, were capable of inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line. Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally. Qualitative and quantitative differences in phenolic composition between the groups of beans influenced the biological activities; on the other hand, we did not find significant differences on the biological activities within the same variety, before and after cooking.

  16. Challenge of goodness: twelve humanitarian proposals based on the experience of 1991-1995 wars in Croatia and Bosnia and Herzegovina.

    Science.gov (United States)

    Lang, S

    1998-03-01

    Based on the 1991-1995 war experience of peoples of Croatia and Bosnia and Herzegovina, I made twelve proposals regarding the following aspects of health, humanitarian work, and human rights: 1. Broadening of the WHO definition of health by including spiritual well-being (absence of hatred) in it, 2. Inclusion of the term genocide into the Index Medicus (MeSH), 3. Establishment of concepts of prevention of hate, 4. Right to a home, 5. Right of civilians to participate in defense and renewal, 6. Right to deliberation from enslavement and right to find out the fate of missing persons, 7. Global hospital, 8. Monitoring of prisoner-of-war camps, 9. Refugee camps, 10. Providing of care for the abandoned - a new category of people suffering in war, 11. Introduction of the Helping Hand concept, 12. Organization of the Red Cross Forum after the cessation of hostilities. The fundamental objective was to establish the legitimacy of honesty in practice, regulative social mechanisms, and science.

  17. A Randomized Controlled Trial of Puncturing and Bloodletting at Twelve Hand Jing Points to Treat Acute Carbon Monoxide Poisoning as Adjunct to First Aid Treatment: A Study Protocol

    Directory of Open Access Journals (Sweden)

    Ying Yue

    2015-01-01

    Full Text Available Background. Acute carbon monoxide poisoning (ACOP is a significant cause of morbidity and mortality in many countries. Twelve Hand Jing Points (THJP have been believed to be effective to treat all kinds of emergency calls in traditional Chinese medicine (TCM for more than 3000 years. This randomized controlled trial (RCT is designed to evaluate the effectiveness of THJP in curing acute carbon monoxide poisoning in first aid treatment. This paper reports the protocol of the trial. Methods/Design. This RCT is a multicenter, randomized, controlled study undergoing in China. The compliant patients are divided into the bloodletting group and standard of care group. With first aid treatments given to both of the groups, the bloodletting group is bleeding at THJP upon being hospitalized. Primary outcomes and secondary outcomes will be measured and compared between these two groups. Before treatment, immediately after treatment, and 30 minutes, 1 hour, and 4 hours after treatment, patients’ basic vital signs and state of consciousness were observed. Before treatment and 1 and 4 hours after treatment, carboxyhemoglobin concentration in venous blood samples was detected. Discussion. The objective of this study is to provide convincing evidence to clarify the efficacy and safety of THJP for early treatment of acute carbon monoxide poisoning.

  18. Eating Attitudes, Perfectionism and Body-esteem of Elite Male Judoists and Cyclists.

    Science.gov (United States)

    Filaire, Edith; Rouveix, Matthieu; Pannafieux, Christelle; Ferrand, Claude

    2007-01-01

    This study tested the hypothesis that male athletes who feel pressured to maintain a specific body weight present an elevated risk of subclinical eating disorders. Twelve judoists (19.5 ± 0.5 yr), fifteen cyclists (21.2 ± 2.8 yr) and seventeen non- competitive students matched for BMI and used as controls (21.8 ± 1.8 yr) were studied using the Eating Attitudes Test (EAT-26). The Multidimensional Perfectionism Scale, the Body Esteem Scale and the Profile of Mood States were also used to evaluate the relationships between eating disorders and psychological characteristics. Athletes completed the tests during their competitive period and controls completed the same scales at the same time. Scores obtained on EAT-26 differed significantly from the control group on EAT (p EAT scores in athletes. Body-esteem Appearance and depression accounted for a significant proportion of the variance in Dieting scores. There was no difference in perfectionism and mood between athletes and controls. This study highlights that these athletes may tread a fine line between optimal competitive attitudes and detrimental health behaviors. Key pointsPrevalence of eating disorders has become a growing concern among athletic populations, but very little information is available concerning male athletes.This study highlights that these athletes may tread a fine line between optimal competitive attitudes and detrimental health behaviors.

  19. The relationship between age and brain response to visual erotic stimuli in healthy heterosexual males.

    Science.gov (United States)

    Seo, Y; Jeong, B; Kim, J-W; Choi, J

    2010-01-01

    The various changes of sexuality, including decreased sexual desire and erectile dysfunction, are also accompanied with aging. To understand the effect of aging on sexuality, we explored the relationship between age and the visual erotic stimulation-related brain response in sexually active male subjects. Twelve healthy, heterosexual male subjects (age 22-47 years) were recorded the functional magnetic resonance imaging (fMRI) signals of their brain activation elicited by passive viewing erotic (ERO), happy-faced (HA) couple, food and nature pictures. Mixed effect analysis and correlation analysis were performed to investigate the relationship between the age and the change of brain activity elicited by erotic stimuli. Our results showed age was positively correlated with the activation of right occipital fusiform gyrus and amygdala, and negatively correlated with the activation of right insula and inferior frontal gyrus. These findings suggest age might be related with functional decline in brain regions being involved in both interoceptive sensation and prefrontal modulation while it is related with the incremental activity of the brain region for early processing of visual emotional stimuli in sexually healthy men.

  20. Solitary neurofibroma in the male breast

    Directory of Open Access Journals (Sweden)

    Smith Mark EF

    2007-02-01

    Full Text Available Abstract Background Neurofibroma of the male breast outside of neurofibromatosis is extremely rare with only one previous case having been reported. Case presentation A 48 year old male patient with a neurofibroma in the breast presenting with gynaecomastia is reported. Clinical and mammogram findings with fine needle aspiration cytology and full histology are presented. Conclusion To our knowledge this is only the second case of a neurofibroma in a male breast in the English literature and the first report to include the mammographic findings.

  1. Psychobiology of Male Homosexuality: Recent Findings

    Directory of Open Access Journals (Sweden)

    Iván Annicchia rico

    2009-06-01

    Full Text Available In this paper, empirical and theoretical reports which question the causes ofmale homosexuality are examined. According to these reports, male homosexualitydiffers from female homosexuality in some respects. Additionally,evidence favouring the consideration of male homosexuality as a biologicalcondition is shown: there are brain differences between gay men and heterosexualmen, there are genetic and perinatal factors associated to malehomosexuality, there are cognitive and behavioral differences between gayand heterosexual men, there are animal models for studying homosexuality;finally, there are negative findings concerning the psychosocial factorsassociated to male homosexuality.

  2. Male contraception: prospects for the new millennium

    Institute of Scientific and Technical Information of China (English)

    W.M.Hair; F.C.W.Wu

    2000-01-01

    Effective regulation of human fertility has global consequences in terms of resource depletion, pollution and poverty. Current family planning services predominantly target a female clientele with few significant developments in male fertility regulation for over a century. The last two decades have witnessed a gathering interest, initially from the scientific community, and laterally from industry, in the development of safe, reliable, reversible methods of contraception for men. This review summarises the methods of male fertility regulation which are currently available and critically examines the published data on novel developments in male hormonal contraception which offer the potential of improved contraceptive choice for all in new millennium. ( Asian J Androl 2000 ; 2 : 3 - 12 )

  3. Total Male Breast Reconstruction with Fat Grafting

    Directory of Open Access Journals (Sweden)

    Tarik Al-Kalla, MD

    2014-11-01

    Full Text Available Summary: Cancer of a male breast represents less than 1% of all breast cancer. As with to female patients, mastectomy in men creates a substantial emotional burden. Breast reconstruction may improve the patient’s psychological well-being, compliance with adjuvant treatments, and overall outcome. However, due to the unique anatomy of the male breast, standard reconstructive strategies using anatomic or prosthetic modalities are not entirely applicable. We describe a case of a 68-year-old male patient who underwent successful unilateral breast reconstruction solely with fat grafting technique.

  4. N-nitrosamines induced infertility and hepatotoxicity in male rabbits.

    Science.gov (United States)

    Sheweita, S A; El Banna, Y Y; Balbaa, M; Abdullah, I A; Hassan, H E

    2017-09-01

    N-nitrosamines are widely spread environmental pollutants of well-known toxicity and carcinogenicity in various animal species. These compounds are metabolically activated by cytochrome P450 system predominantly in the liver and in other tissues into more active metabolites leading to generation of both alkylating agents that alkylate DNA and reactive oxygen species. In the current study, we investigated the influence of four types of N-nitrosamines that are commonly present in the environment [methyethylnitrosamine, (MEN), diethylnitrosamine (DEN), diphenylnitroasamine (DPN) and dimethylnitrosamine (DMN)] on both livers and testes of male rabbits through assessment of 17 β-hydroxysteroid dehydrogenase (17 β-HSD) activity. The protein expression of the three cytochrome P450s (CYP11A1, CYP19A1, and CYP21A2) is involved in the steroidogenesis. The levels of testosterone (T) and estradiol (E2) were also determined in the plasma of N-nitrosamines-treated rabbits after one, four-, eight- and twelve weeks of treatment of male New Zealand rabbits with an oral dose of 0.5 mg/kg B.W/day of each compound. In addition, activities of glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT) and levels of free radicals measured as thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) level were quantified in both livers and testes. The present study showed that levels of free radicals (TBARS) were markedly increased, whereas GSH levels were depleted in the tissues of both livers and testes after treatment of rabbits with any of N-nitrosamines. In addition, all tested N-nitrosamines inhibited the activities of antioxidant enzyme activities (GR, GST, SOD, and CAT) in hepatic and testicular tissues of rabbits after 12 weeks of treatment. Histopathological examination showed that N-nitrosamines caused lymphocytic infiltration with vascular degeneration and necrosis, congestion of central vein with RBCs hemolysis, dilated sinusoids, as well as

  5. Hybrid male sterility and genome-wide misexpression of male reproductive proteases.

    Science.gov (United States)

    Gomes, Suzanne; Civetta, Alberto

    2015-07-06

    Hybrid male sterility is a common barrier to gene flow between species. Previous studies have posited a link between misregulation of spermatogenesis genes in interspecies hybrids and sterility. However, in the absence of fully fertile control hybrids, it is impossible to differentiate between misregulation associated with sterility vs. fast male gene regulatory evolution. Here, we differentiate between these two possibilities using a D. pseudoobscura species pair that experiences unidirectional hybrid sterility. We identify genes uniquely misexpressed in sterile hybrid male reproductive tracts via RNA-seq. The sterile male hybrids had more misregulated and more over or under expressed genes relative to parental species than the fertile male hybrids. Proteases were the only gene ontology class overrepresented among uniquely misexpressed genes, with four located within a previously identified hybrid male sterility locus. This result highlights the potential role of a previously unexplored class of genes in interspecific hybrid male sterility and speciation.

  6. Remote copulation: male adaptation to female cannibalism.

    Science.gov (United States)

    Li, Daiqin; Oh, Joelyn; Kralj-Fiser, Simona; Kuntner, Matjaz

    2012-08-23

    Sexual cannibalism by females and associated male behaviours may be driven by sexual conflict. One such male behaviour is the eunuch phenomenon in spiders, caused by total genital emasculation, which is a seemingly maladaptive behaviour. Here, we provide the first empirical testing of an adaptive hypothesis to explain this behaviour, the remote copulation, in a highly sexually cannibalistic orb-web spider Nephilengys malabarensis. We demonstrate that sperm transfer continues from the severed male organ into female genitals after the male has been detached from copula. Remote copulation increases the total amount of sperm transferred, and thus probably enhances paternity. We conclude that the mechanism may have evolved in response to sexual cannibalism and female-controlled short copulation duration.

  7. Unexplained male infertility: diagnosis and management.

    Science.gov (United States)

    Hamada, Alaa; Esteves, Sandro C; Nizza, Mark; Agarwal, Ashok

    2012-01-01

    Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertility include low level leukocytospermia and mitochondrial DNA polymerase gene polymorphism. Contemporary andrology may reveal cellular and sub-cellular sperm dysfunctions which may explain subfertility in such cases, thus aiding the clinician to direct the further work-up, diagnosis and counseling of the infertile male. The objective of this article is to highlight the concept of unexplained male infertility and focuses on the diagnosis and treatment of this condition in the era of modern andrology and assisted reproductive techniques. Extensive literature review was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus.

  8. Unexplained Male infertility: diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Alaa Hamada

    2012-10-01

    Full Text Available Unexplained male infertility is a diagnosis reserved for men in whom routine semen analyses results are within normal values and physical as well as endocrine abnormalities were ruled out. In addition to erectile problems and coital factors, immunologic causes and sperm dysfunction may contribute to such condition. New etiologies of unexplained male infertility include low level leukocytospermia and mitochondrial DNA polymerase gene polymorphism. Contemporary andrology may reveal cellular and sub-cellular sperm dysfunctions which may explain subfertility in such cases, thus aiding the clinician to direct the further work-up, diagnosis and counseling of the infertile male. The objective of this article is to highlight the concept of unexplained male infertility and focuses on the diagnosis and treatment of this condition in the era of modern andrology and assisted reproductive techniques. Extensive literature review was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus.

  9. Male breast cancer: is the scenario changing

    Directory of Open Access Journals (Sweden)

    Kulkarni Dhananjay M

    2008-06-01

    Full Text Available Abstract Background The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects of male breast cancer with particular emphasis on incidence, risk factors, patho-physiology, treatment, prognostic factors, and outcome. Methods Information on all aspects of male breast cancer was gathered from available relevant literature on male breast cancer from the MEDLINE database over the past 32 years from 1975 to 2007. Various reported studies were scrutinized for emerging evidence. Incidence data were also obtained from the IARC, Cancer Mondial database. Conclusion There is a scenario of rising incidence, particularly in urban US, Canada and UK. Even though more data on risk factors is emerging about this disease, more multi-institutional efforts to pool data with large randomized trials to show treatment and survival benefits are needed to support the existing vast emerging knowledge about the disease.

  10. Male teachers' experiences of own aggression

    African Journals Online (AJOL)

    understanding of aggressive behaviour, Transformative Learning Theory ... Male teachers who are aggressive typically use verbal, sexual, or physical assault. ... regard of other individuals' human values and reduces criticism of one's own ...

  11. FEASIBILITY OF MEDICAL MALE CIRCUMCISION IN NYANZA ...

    African Journals Online (AJOL)

    hi-tech

    2004-05-05

    May 5, 2004 ... necessary resources and training to perform the procedure safely. ... of the district health management team. ..... and human immunodeficiency virus transmission in Kenya ... Weiss, H.A., Quigley, M.A., and Hayes, R. J., Male.

  12. Reproductive physiology of the male camelid.

    Science.gov (United States)

    Bravo, P W; Johnson, L W

    1994-07-01

    The physiology of reproduction with emphasis on endocrinology of llamas and alpacas is addressed. Information regarding male anatomy, puberty, testicular function, semen description, and sexual behavior is also included.

  13. God as Father: The maleness of God

    Directory of Open Access Journals (Sweden)

    D. T. Williams

    1990-03-01

    Full Text Available It is fashionable today to try to avoid sexist language in theology, despite the Bible’s consistent use of the masculine pronoun when referring to God. Although such an attempt has largely been engendered by modem culture, the maleness of God is not simply a hangover from a patriarchal society, but reflects a fundamental maleness in God’s dealing with man. It emphasises the idea of redemption by grace alone over against creation, and such aspects as the adoption of Christians as sons. The maleness of Christ likewise has not simply been cultural, but is significant theologically. This is not to deny any femininity in God, but to assert that male features predominate. Such an idea does not reduce the status of women, but rather an emphasis on redemption raises it. Raising the status of women in society would in fact reduce the pressure to demasculinize God.

  14. Male microchimerism and survival among women

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Hjalgrim, Henrik; Andersen, Anne-Marie Nybo

    2014-01-01

    During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status.......During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status....

  15. Water-flea males from the netherworld.

    Science.gov (United States)

    Minelli, Alessandro; Fusco, Giuseppe

    2006-09-01

    Simple treatments with hormones could unlock the expression of complex phenotypes not known to occur in nature. Using this method, Kim et al. recently obtained males from all-female populations of water fleas. The novel characters revealed by this work can be used in taxonomic identification and phylogenetic inference. Additionally, these "resurrected" males offer insights into the conservation of traits that are not exposed to natural selection.

  16. Role of Ultrasound in Male Infertility

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Min Hoan; Sung, Chang Kyu [Dept. of Radiology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2012-06-15

    US evaluation is the mainstay of diagnostic imaging of infertile men. In this editorial, we review the spectrum of diseases responsible for male infertility, discuss the way in which US imaging studies can be used for evaluation of male infertility, and illustrate characteristic US imaging features that allow for specific diagnosis. The discussion will be divided into three main categories: obstruction in sperm passage, impairment of sperm function, and defect in sperm genesis.

  17. Psychobiology of Male Homosexuality: Recent Findings

    OpenAIRE

    Iván Annicchia rico

    2009-01-01

    In this paper, empirical and theoretical reports which question the causes ofmale homosexuality are examined. According to these reports, male homosexualitydiffers from female homosexuality in some respects. Additionally,evidence favouring the consideration of male homosexuality as a biologicalcondition is shown: there are brain differences between gay men and heterosexualmen, there are genetic and perinatal factors associated to malehomosexuality, there are cognitive and behavioral differenc...

  18. Male Anorexia Nervosa: an Exploratory Study

    OpenAIRE

    Crosscope-Happel, Cindy

    1999-01-01

    Anorexia nervosa is a serious problem that affects over one million males yearly. It is often misdiagnosed and overlooked completely in clinical, medical and school settings because of the misperception that it is a disorder exclusively present in females. The DSM-IV largely contributes to this misnomer due to the gender-biased criteria. The purpose of this exploratory study was to identify the etiology and clinical characteristics of male anorexia and devise a more comprehensive defi...

  19. Pharmacologic development of male hormonal contraceptive agents.

    Science.gov (United States)

    Roth, M Y; Amory, J K

    2011-01-01

    The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help in preventing un intended pregnancies and managing future population growth. Male hormonal contraception relies on the administration of exogenous hormones to suppress spermatogenesis. Clinical trials have tested several regimens using testosterone, alone or in combination with a progestin. These regimens were shown to be >90% effective in preventing conception and were not associated with serious adverse events.

  20. LUNG CARCINOMA IN YOUNG ADULT MALES

    Directory of Open Access Journals (Sweden)

    Dhanasekar

    2015-05-01

    Full Text Available Here we report three case of Lung Carcinoma in young adult males, non - smokers, no family history of malignancy and no other risk factors like occupational or environmental exposure, past history of tuberculosis or chronic obstructive bronchitis, who presented with variable chest radiographic and computerized tomog raphic findings, these cases warrants further analysis regarding the changing trend of higher incidents of lung carcinoma in young adult males.

  1. LUNG CARCINOMA IN YOUNG ADULT MALES

    OpenAIRE

    Dhanasekar; Anbumaran; Rajagopalan; Shanmugapriya

    2015-01-01

    Here we report three case of Lung Carcinoma in young adult males, non - smokers, no family history of malignancy and no other risk factors like occupational or environmental exposure, past history of tuberculosis or chronic obstructive bronchitis, who presented with variable chest radiographic and computerized tomog raphic findings, these cases warrants further analysis regarding the changing trend of higher incidents of lung carcinoma in young adult males.

  2. Vitamin D, men's health and male reproduction

    Directory of Open Access Journals (Sweden)

    I. A. Tyuzikov

    2014-11-01

    Full Text Available In the literary review the modern data proving an important physiological role of vitamin D and its deficiency for man's health in whole and the male reproduction, in particular is presented. For today these proofs are based basically on experimental works with animals and on clinical observant researches which demonstrative base while is insufficient for a formulation of the general concept of vitamin D deficiency for modern medicine. However, there are some encouraging results deserving a complex estimation and the further basic researches. Considering high prevalence of male infertility, not diagnosed androgen deficiency and vitamin D at men, which have intime authentic pathophysiological communications, it is possible to assume that the further researches in area endocrinology of vitamin D can come to new methods of an estimation of men's reproductive function and working out of new pathogenetic therapeutic approaches in male infertility treatment. These prospects are especially important if to consider that infertility suffers not less than 10–20 % of married couples, and this figure constantly increases. In spite of the fact that vitamin D is not included yet into the list of preparations for treatment of male infertility, but its influence at male androgen status which is endocrinological basis of sexual and reproductive functions, and positive effects at spermatogenesis in experimental researches is necessary to consider proved. Besides, large-scale clinical randomized researches are necessary for definition of an optimal 25(OH-vitamin D level for prevention and treatment of male fertility's disorders.

  3. Vitamin D, men's health and male reproduction

    Directory of Open Access Journals (Sweden)

    I. A. Tyuzikov

    2013-01-01

    Full Text Available In the literary review the modern data proving an important physiological role of vitamin D and its deficiency for man's health in whole and the male reproduction, in particular is presented. For today these proofs are based basically on experimental works with animals and on clinical observant researches which demonstrative base while is insufficient for a formulation of the general concept of vitamin D deficiency for modern medicine. However, there are some encouraging results deserving a complex estimation and the further basic researches. Considering high prevalence of male infertility, not diagnosed androgen deficiency and vitamin D at men, which have intime authentic pathophysiological communications, it is possible to assume that the further researches in area endocrinology of vitamin D can come to new methods of an estimation of men's reproductive function and working out of new pathogenetic therapeutic approaches in male infertility treatment. These prospects are especially important if to consider that infertility suffers not less than 10–20 % of married couples, and this figure constantly increases. In spite of the fact that vitamin D is not included yet into the list of preparations for treatment of male infertility, but its influence at male androgen status which is endocrinological basis of sexual and reproductive functions, and positive effects at spermatogenesis in experimental researches is necessary to consider proved. Besides, large-scale clinical randomized researches are necessary for definition of an optimal 25(OH-vitamin D level for prevention and treatment of male fertility's disorders.

  4. Non-therapeutic infant male circumcision

    Science.gov (United States)

    Alkhenizan, Abdullah; Elabd, Kossay

    2016-01-01

    Objectives: To review the evidence of the benefits and harms of infant male circumcision, and the legal and ethical perspectives of infant male circumcision. Methods: We conducted a systematic search of the literature using PubMed, EMBASE, and the Cochrane library up to June 2015. We searched the medical law literature using the Westlaw and Lexis Library law literature resources up to June 2015. Results: Male circumcision significantly reduced the risk of urinary tract infections by 87%. It also significantly reduced transmission of human immunodeficiency virus among circumcised men by 70%. Childhood and adolescent circumcision is associated with a 66% reduction in the risk of penile cancer. Circumcision was associated with 43% reduction of human papilloma virus infection, and 58% reduction in the risk of cervical cancer among women with circumcised partners compared with women with uncircumcised partners. Male infant circumcision reduced the risk of foreskin inflammation by 68%. Conclusion: Infant male circumcision should continue to be allowed all over the world, as long as it is approved by both parents, and performed in facilities that can provide appropriate sterilization, wound care, and anesthesia. Under these conditions, the benefits of infant male circumcision outweigh the rare and generally minor potential harms of the procedure. PMID:27570848

  5. Perceptions and opinions about male breast cancer and male breast self-examination: a qualitative study.

    Science.gov (United States)

    Al-Naggar, Redhwan Ahmed; Al-Naggar, Dhekra Hamoud

    2012-01-01

    While the relatively common nature of female breast cancer has resulted in a high level of general awareness, male breast cancer is still comparatively unknown to the general public and to healthcare professionals. The objective of this study is to explore the perceptions and opinions about male breast cancer and male breast self-examination among male university students. In-depth interviews were conducted among 36 male university students from the Management and Science University, Malaysia, selected by simple random sampling. The themes of the interview were: knowledge of male breast cancer and male breast self-examination, sources of knowledge and attitudes towards male BSE. The data obtained were classified into various categories and analyzed manually. The majority of participants mentioned that there is a low possibility for males to get breast cancer. They also believed that the cause of breast cancer among men is due to the carcinogens from cigarettes. The majority of participants mentioned that they know about breast self-examination from the mass media and that the presence of a lump in the breast is the main symptom of breast cancer in men. The majority of participants mentioned that they encourage their family members to practice breast self-examination but considered that BSE is not important for men because they have a low probability of getting breast cancer. Misconceptions regarding male breast cancer and breast self-examination among men still exist among male university students. Therefore special attention should be given to educate men about male breast cancer and male BSE.

  6. Cubitene: an irregular twelve-membered-ring diterpene from a termite soldier. [1,5-dimethyl-8,10-bis(isopropenyl)cyclododeca-1,5-diene

    Energy Technology Data Exchange (ETDEWEB)

    Prestwich, G.D. (International Centre of Insect Physiology and Ecology, Nairobi, Kenya); Wiemer, D.F.; Meinwald, J.; Clardy, J.

    1978-04-12

    Cubitene was isolated from the hexane extract of C. umbratus soldier heads by chromatography over Florisil followed by preparative GLC. High resolution mass spectroscopy indicated the formula of cubitene to be C/sub 20/H/sub 32/. Mass spectra of catalytically hydrogenated cubitene products showed peaks at m/rho 279, consistent with their formulation as substituted cycloalkanes of the composition C/sub 20/H/sub 40/. Cubitene is therefore a monocyclic hydrocarbon with four centers of unsaturation. the /sup 1/H NMR spectral data revealed the presence of two 1,1-disubstituted double bonds, and two additional olefinic protons. Four methyl groups attached to double bonds are also observed. The /sup 13/C NMR spectrum indicated the presence of two tribsubstituted double bonds. Fortunately, cubitene could be obtained in crystalline form (mp 34.5-35/sup 0/C) from cold methanol, allowing a single-crystal x-ray diffraction analysis. It crystallized in the monoclinic crystal class. Lattice parameters were: a = 15.963 (5), b = 6.799 (2), c = 17.038 (5) A; theta = 96.99 (2)/sup 0/. Evidence shows cubitene to be 1,5-dimethyl-8,10-bis(isopropenyl)cyclododeca-1,5-diene, a structure in which one isoprene unit is irregularly joined to three others. It appears to be the first example of a diterpene hydrocarbon based on a twelve-membered carbocyclic ring. Its biosynthesis poses interesting problems. Two possible biosynthetic routes are suggested. An even more basic question remains....whether termite soldiers synthesize cubitene at all, or whether they simply sequester it (or a closely related precursor) from their food.

  7. How does lead induce male infertility?

    Directory of Open Access Journals (Sweden)

    Ping-Chi Hsu

    2011-01-01

    Full Text Available An important part of male infertility of unknown etiology may be attributed to various environmental and occupational exposures to toxic substances, such as lead. The reproductive effects of lead are complex and appear to involve multiple pathways, not all of which are fully understood. It is still unclear, for example, if male reproductive issues in lead-exposed persons are mostly related to the disruption of reproductive hormones, whether the problems are due to the lead’s direct effects on the gonads, or both? This question has been difficult to answer, because lead, especially at high levels, may adversely affect many human organs. Although lead can potentially reduce male fertility by decreasing sperm count and motility, inducing abnormal morphology and affecting functional parameters; not all studies have been able to clearly demonstrate such findings. In addition, research has shown that the blood-testis barrier can protect testicular cells from direct exposure to high levels of blood lead. For these reasons and considering the wide spectrum of lead toxicity on reproductive hormones, the present review suggests that lead’s main influence on male reproduction probably occurs by altering the reproductive hormonal axis and the hormonal control on spermatogenesis, rather than by a direct toxic effect on the seminiferous tubules of the testes. As blood lead concentrations below the currently accepted worker protection standard may still adversely affect male fertility, future studies should aim to establish more concrete links between lead exposure (especially at low levels and subsequent male infertility. Research should also pay more attention to lead’s effects on reducing male fertility rates based on not only hormonal axis alteration, but also on the changes in sperm characteristic among exposed subjects.

  8. Male breast cancer: clinical presentation, diagnosis, treatment.

    Science.gov (United States)

    Hotko, Y S

    2013-12-01

    Despite male breast cancer is rare in occurrence, it is a serious problem. In 2012, 130 men in Ukraine got breast cancer that constituted 0.74% from all patients with mentioned pathology detected in the course of year. Every year in Ukraine approximately 100 men die from breast cancer. Still many aspects of male breast cancer remain unstudied. It occurs since information about mentioned disease is mainly based on retrospective analysis of small groups. Treatment of men, who got breast cancer, is based on knowledge, which has been obtained in treatment of women with this pathology. This article is based on the results of analysis of 168 cases of breast cancer in men, who have been examined and treated in the period from 1956 to 2012. In paper the peculiarities of clinical manifestations of male breast cancer have been determined, the optimal volume of diagnostic procedures in men with suspicion of breast cancer has been established, the mammographic signs have been detected and the possible histological variants of disease have been determined, clinical course peculiarities of male breast cancer have been defined, the most essential factors of prognosis of the disease have been fixed. Furthermore, in article optimal volume of surgical treatment of male breast cancer has been substantiated, the role and place of radiotherapy in treatment of this pathology has been determined. It has been proved that adjuvant polychemotherapy should be applied to the patients with male breast cancer independently from stage of process. Also optimal schemes of this kind of treatment have been determined. The efficacy of hormonal therapy with antiestrogen in patients with positive receptors of steroid hormones and at presence of unfavorable prognostic factors of disease has been demonstrated. The inefficiency of orchiectomy as one of the widespread kinds of hormonal therapy of male breast cancer has been defined.

  9. Twelve-year analysis of cattle and buffalo slaughtering in Lazio Region (2000-2012: animal husbandry and veterinary public health implications

    Directory of Open Access Journals (Sweden)

    Selene Marozzi

    2014-02-01

    Full Text Available In recent years, beef meat chain has undergone major transformations due to Community legislation and market changes. The purpose of this work is to analyse the information recorded in Banca Dati Nazionale (BDN; Italian computerised database for the identification and registration of bovine animals on cattle and buffaloes slaughtered between 2000 and 2012 and related to Lazio Region as a result of breeding and/or slaughtering place. The analysis of the data showed a negative trend (-20.7% for cattle slaughtered from 2000 to 2012. Most of this animals had been raised in Lazio Region (86% and in particular in the province of Frosinone. The average age at slaughter for female is about 4 years (1417 days and for males of 547 days. The buffaloes, however, are intended for slaughter at an average age of about 8 years, if female, and about one year if male.

  10. Twelve-Year Analysis of Cattle and Buffalo Slaughtering in Lazio Region (2000-2012): Animal Husbandry and Veterinary Public Health Implications

    Science.gov (United States)

    Marozzi, Selene; Scaramozzino, Paola

    2014-01-01

    In recent years, beef meat chain has undergone major transformations due to Community legislation and market changes. The purpose of this work is to analyse the information recorded in Banca Dati Nazionale (BDN; Italian computerised database for the identification and registration of bovine animals) on cattle and buffaloes slaughtered between 2000 and 2012 and related to Lazio Region as a result of breeding and/or slaughtering place. The analysis of the data showed a negative trend (-20.7%) for cattle slaughtered from 2000 to 2012. Most of this animals had been raised in Lazio Region (86%) and in particular in the province of Frosinone. The average age at slaughter for female is about 4 years (1417 days) and for males of 547 days. The buffaloes, however, are intended for slaughter at an average age of about 8 years, if female, and about one year if male. PMID:27800314

  11. Female sticklebacks use male coloration in mate choice and hence avoid parasitized males

    Science.gov (United States)

    Milinski, Manfred; Bakker, Theo C. M.

    1990-03-01

    AN important problem in evolutionary biology since the time of Darwin has been to understand why females preferentially mate with males handicapped by secondary sexual ornaments1-3. One hypothesis of sexual selection theory is that these ornaments reliably reveal the male's condition4-6, which can be affected for example by parasites4,7-13. Here we show that in the three-spined stickleback (Gasterosteus aculeatus) the intensity of male red breeding coloration positively correlates with physical condition. Gravid females base their active mate choice on the intensity of the male's red coloration. Choice experiments under green light prevent the use of red colour cues by females, and males that were previously preferred are now chosen no more than randomly, although the courtship behaviour of the males remains unchanged. Parasitieation causes a deterioration in the males' condition and a decrease in the intensity of their red coloration. Tests under both lighting conditions reveal that the females recognize the formerly parasitized males by the lower intensity of their breeding coloration. Female sticklebacks possibly select a male with a good capacity for paternal care14 but if there is additive genetic variation for parasite resistance, then they might also select for resistance genes, as proposed by Hamilton and Zuk4.

  12. Differences in Nuclear DNA Between Male-Sterile and Male-Fertile Lines of Sorghum bicolor

    Institute of Scientific and Technical Information of China (English)

    FAN Chang-fa; SUN Chun-yun; GUO Xiao-cai; NIU Tian-tang; ZHANG Fu-yao

    2003-01-01

    Cytoplasmic male sterility (cms) is determined by nuclear-cytoplasmic interactions. Up tonow, most studies are focused on the comparison of cytoplasmic DNAs of male-sterile lines and male-fertilelines, and analysis of nuclear DNA has not been documented yet. In order to find out the possible difference innuclear genome of male-sterile line A1 Tx623 and corresponding male-fertile line Tx623 of sorghum, randomamplified polymorphic DNA (RAPD) approach was used to analyze their cytoplasmic and nuclear genomes.Total DNAs of them were amplified at first to screen primers, which were able to generate reproducible bandsspecific to male-sterile line or male-fertile line. Then the selected primers were used to amplify their mitochon-drial DNA (mtDNA) and chloroplast DNA (cpDNA). The origins of all the polymorphic fragments were ana-lyzed. After ruling out those amplified from cytoplasmic DNA, seventeen polymorphic fragments were deter-mined to be amplified from nuclear DNA. These fragments originated from nuclear DNA indicate that diffe-rences in sequence exist between the nuclear DNA of male-sterile line and male-fertile line of sorghum, whichdo not agree with the traditional standpoint that they have identical nucleus.

  13. Repeated Bout Effect Was More Expressed in Young Adult Males Than in Elderly Males and Boys

    Directory of Open Access Journals (Sweden)

    Giedrius Gorianovas

    2013-01-01

    Full Text Available This study investigated possible differences using the same stretch-shortening exercise (SSE protocol on generally accepted monitoring markers (dependent variables: changes in creatine kinase, muscle soreness, and voluntary and electrically evoked torque in males across three lifespan stages (childhood versus adulthood versus old age. The protocol consisted of 100 intermittent (30 s interval between jumps drop jumps to determine the repeated bout effect (RBE (first and second bouts performed at a 2-week interval. The results showed that indirect symptoms of exercise-induced muscle damage after SSE were more expressed in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are more resistant to exercise-induced damage than those of adult males. RBE was more pronounced in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are less adaptive to exercise-induced muscle damage than those of adult males.

  14. Mitochondria, maternal inheritance, and male aging.

    Science.gov (United States)

    Camus, M Florencia; Clancy, David J; Dowling, Damian K

    2012-09-25

    The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species.

  15. Mouse models in male fertility research

    Institute of Scientific and Technical Information of China (English)

    Duangporn Jamsai; Moira K O'Bryan

    2011-01-01

    Limited knowledge of the genetic causes of male infertility has resulted in few treatment and targeted therapeutic options.Although the ideal approach to identify infertility causing mutations is to conduct studies in the human population,this approach has progressed slowly due to the limitations described herein.Given the complexity of male fertility,the entire process cannot be modeled in vitro.As such,animal models,in particular mouse models,provide a valuable alternative for gene identification and experimentation.Since the introduction of molecular biology and recent advances in animal model production,there has been a substantial acceleration in the identification and characterization of genes associated with many diseases,including infertility.Three major types of mouse models are commonly used in biomedical research,including knockout/knockin/gene-trapped,transgenic and chemical-induced point mutant mice.Using these mouse models,over 400 genes essential for male fertility have been revealed.It has,however,been estimated that thousands of genes are involved in the regulation of the complex process of male fertility,as many such genes remain to be characterized.The current review is by no means a comprehensive list of these mouse models,rather it contains examples of how mouse models have advanced our knowledge of post-natal germ cell development and male fertility regulation.

  16. Does Halitosis Effect Sexual Life in Males?

    Directory of Open Access Journals (Sweden)

    Gul Soylu Ozler

    2014-03-01

    Full Text Available Aim: Halitosis is an unpleasant alteration of the halitus. The aim of the study is to assess the quality of sexual life of males with and without halitosis. Material and Method: Males between 20-50 years old; with a complaint of halitosis; married and able to complete the study were included in the study. The control group were healthy, adult, married males who have normal otorhinolaryngologic examination. The International Index of Erectile Function questionnaire(IIEF were used to assess the quality of sexual life  of males with halitosis and the results were compared with a similar group of healthy men. Results: A total of 80 adult subjects completed the study. When the groups were compared in terms of age, body mass index(BMI and duration of marriage, they were similar (p=0.65, p= 0.20, p= 0.08 respectively.The halitosis group had significantly lower scores for all function domains (p=0.0001.There was no correlation between degree of halitosis and the scores of IIEF (p< 0.05. Discussion: This is the first study investigating the sexual health of males with halitosis. Halitosis not only effects oral health status but also strongly declines quality of life. The otorhinolaryngologist must not only treat halitosis but also help the patient to stand up to social and sexual problems concomitting halitosis.

  17. Dispersal of Engineered Male Aedes aegypti Mosquitoes.

    Science.gov (United States)

    Winskill, Peter; Carvalho, Danilo O; Capurro, Margareth L; Alphey, Luke; Donnelly, Christl A; McKemey, Andrew R

    2015-11-01

    Aedes aegypti, the principal vector of dengue fever, have been genetically engineered for use in a sterile insect control programme. To improve our understanding of the dispersal ecology of mosquitoes and to inform appropriate release strategies of 'genetically sterile' male Aedes aegypti detailed knowledge of the dispersal ability of the released insects is needed. The dispersal ability of released 'genetically sterile' male Aedes aegypti at a field site in Brazil has been estimated. Dispersal kernels embedded within a generalized linear model framework were used to analyse data collected from three large scale mark release recapture studies. The methodology has been applied to previously published dispersal data to compare the dispersal ability of 'genetically sterile' male Aedes aegypti in contrasting environments. We parameterised dispersal kernels and estimated the mean distance travelled for insects in Brazil: 52.8 m (95% CI: 49.9 m, 56.8 m) and Malaysia: 58.0 m (95% CI: 51.1 m, 71.0 m). Our results provide specific, detailed estimates of the dispersal characteristics of released 'genetically sterile' male Aedes aegypti in the field. The comparative analysis indicates that despite differing environments and recapture rates, key features of the insects' dispersal kernels are conserved across the two studies. The results can be used to inform both risk assessments and release programmes using 'genetically sterile' male Aedes aegypti.

  18. Metabolic syndrome and male infertility (review

    Directory of Open Access Journals (Sweden)

    I. A. Tyuzikov

    2013-01-01

    Full Text Available The literary review is devoted to one of the most actual problems of modern andrology – pathogenetic communication of metabolic syndrome components and male infertility. Now a steady growth of metabolic syndrome frequency in world men population is observed, and that is accompanied by progressing deterioration of fertility parameters at them. Negative influence of key metabolic syndrome components – obesity and insulin resistance – at male reproductive function is shown on the basis of modern clinical, epidemiological and experimental data, and known pathophysiological mechanisms of this influence are described also. Induced by a metabolic syndrome oxidative stress of spermatozoas, neuropathy and androgen deficiency are the most significant mechanisms of neuro-endocrinological and reproductive consequences realization. The imperative necessity of early revealing and pharmacological correction of obesity and insulin resistance in all infertility men is shown, as well as they are curable reasons of male infertility . However, they seldom come to light and even less often corrected in routine clinical practice owing to insufficient knowledge of urologists and andrologists about these system hormonal-metabolic factors of male infertility, which role in male infertility pathogenesis will increase only in the conditions of world epidemic of a metabolic syndrome.

  19. Metabolic syndrome and male infertility (review

    Directory of Open Access Journals (Sweden)

    I. A. Tyuzikov

    2014-11-01

    Full Text Available The literary review is devoted to one of the most actual problems of modern andrology – pathogenetic communication of metabolic syndrome components and male infertility. Now a steady growth of metabolic syndrome frequency in world men population is observed, and that is accompanied by progressing deterioration of fertility parameters at them. Negative influence of key metabolic syndrome components – obesity and insulin resistance – at male reproductive function is shown on the basis of modern clinical, epidemiological and experimental data, and known pathophysiological mechanisms of this influence are described also. Induced by a metabolic syndrome oxidative stress of spermatozoas, neuropathy and androgen deficiency are the most significant mechanisms of neuro-endocrinological and reproductive consequences realization. The imperative necessity of early revealing and pharmacological correction of obesity and insulin resistance in all infertility men is shown, as well as they are curable reasons of male infertility . However, they seldom come to light and even less often corrected in routine clinical practice owing to insufficient knowledge of urologists and andrologists about these system hormonal-metabolic factors of male infertility, which role in male infertility pathogenesis will increase only in the conditions of world epidemic of a metabolic syndrome.

  20. Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects

    DEFF Research Database (Denmark)

    Gliemann, Lasse; Rytter, Nicolai; Lindskrog, Mads

    2017-01-01

    Endothelial mechanotransduction is important for vascular function but alterations and activation of vascular mechanosensory proteins have not been investigated in humans. In endothelial cell culture, simple sugars effectively impair mechanosensor proteins. To study mechanosensor- and vascular...... function in humans, twelve young healthy male subjects supplemented their diet with 3 × 75 g sucrose day(-1) for 14 days in a randomized cross-over design. Before and after the intervention period, the hyperemic response to passive lower leg movement and active knee extensor exercise was determined...... %) and to 12 watts of active exercise (by 9 ± 1 %), indicating impaired vascular function. Reduced flow response to passive and active exercise was paralleled by a significant upregulation of Platelet endothelial cell adhesion molecule (PECAM-1), endothelial nitric oxide synthase, NADPH oxidase and the Rho...

  1. Sexually Transmitted Disease and Male Infertility

    DEFF Research Database (Denmark)

    Fode, Mikkel; Fusco, Ferdinando; Lipshultz, Larry

    2016-01-01

    CONTEXT: Theoretically, sexually transmitted diseases (STDs) have the potential to disrupt male fertility; however, the topic remains controversial. OBJECTIVE: To describe the possible association between STDs and male infertility and to explore possible pathophysiologic mechanisms. EVIDENCE...... ACQUISITION: We performed a systematic literature review in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library were searched for articles published before January 1, 2016, using the MeSH terms for a variety of STDs and infertility. The search was restricted to human studies...... performed in men and published in English. Studies were included if they contained original data on a possible association or a cause-and-effect relationship between STD and male infertility. Studies were considered only if they included an appropriate control group and/or comprehensive laboratory data. Due...

  2. Interventional Radiology of Male Varicocele: Current Status

    Energy Technology Data Exchange (ETDEWEB)

    Iaccarino, Vittorio, E-mail: vittorio.iaccarino@unina.it; Venetucci, Pietro [University of Naples ' Federico II' , Diagnostic Imaging Department-Cardiovascular and Interventional Radiology, School of Medicine (Italy)

    2012-12-15

    Varicocele is a fairly common condition in male individuals. Although a minor disease, it may cause infertility and testicular pain. Consequently, it has high health and social impact. Here we review the current status of interventional radiology of male varicocele. We describe the radiological anatomy of gonadal veins and the clinical aspects of male varicocele, particularly the physical examination, which includes a new clinical and ultrasound Doppler maneuver. The surgical and radiological treatment options are also described with the focus on retrograde and antegrade sclerotherapy, together with our long experience with these procedures. Last, we compare the outcomes, recurrence and persistence rates, complications, procedure time and cost-effectiveness of each method. It clearly emerges from this analysis that there is a need for randomized multicentre trials designed to compare the various surgical and percutaneous techniques, all of which are aimed at occlusion of the anterior pampiniform plexus.

  3. Unilateral galactocele in a male infant

    Directory of Open Access Journals (Sweden)

    Vlahović Aleksandar

    2015-01-01

    Full Text Available Introduction. Galactocele, generally occuring in young women during or after lactation, is an extremely rare cause of breast enlargement in infants and children of exclusively male gender. Only 26 cases have been published so far, including two our cases. Case report. We described unilateral, cystic, breast enlargement, without any endocrinologic and other abnormalities in a 29-month-old boy. A typical clinical and histopathologic presentation of galactocele was followed with a complete excision. Conclusion. This was a 27th well documented case of galactocele in a male infant with typical clinical and histopathologic presentation. There are several hypotheses regarding etiology of the lesion, but it is likely to be multifactorial. Because of its extreme rarity, there are some difficulties in differential diagnosis and treatment options of galactocele in male infants.

  4. Three new methods for male contraception

    Institute of Scientific and Technical Information of China (English)

    AhmedShafik

    1999-01-01

    The methods devised for male contraception are meagre. In the current communication, we review 3 recently de-veloped methods applied for male contraception: testicular suspension, polyester-induced azoospermia and prolactin in-jection. The testicle was suspended in the superficial inguinal pouch close to the scrotal neck using 2 methods: stitchand ball. The azoospermic effect of the polyester sling seems to be due to 1) creation of electn~static field across theinWascrotal slructures, and 2) disordered thermoregulation. Pmlactin administration, as a contraceptive method is effi-cient and safe and has the potential to be developed as a male contraceptive. The effect of the above mentioned 3 methods is reversible. These methods, especially testicular suspension and polyester suspensors, are simple and easilyapplicable and were well acceptable by the subjects.( Asian J Androl 1999 Dec; 1:161-167)

  5. Alcohol references on undergraduate males' Facebook profiles.

    Science.gov (United States)

    Egan, Katie G; Moreno, Megan A

    2011-09-01

    Perceived peer alcohol use is a predictor of consumption in college males; frequent references to alcohol on Facebook may encourage alcohol consumption. Content analysis of college males' Facebook profiles identified references to alcohol. The average age of 225 identified profiles was 19.9 years. Alcohol references were present on 85.3% of the profiles; the prevalence of alcohol was similar across each undergraduate grade. The average number of alcohol references per profile was 8.5 but increased with undergraduate year (p = .003; confidence interval = 1.5, 7.5). Students who were of legal drinking age referenced alcohol 4.5 times more than underage students, and an increase in number of Facebook friends was associated with an increase in displayed alcohol references (p < .001; confidence interval = 0.009, 0.02). Facebook is widely used in the college population; widespread alcohol displays on Facebook may influence social norms and cause increases in male college students' alcohol use.

  6. High male fertility in males of a subdioecious shrub in hand-pollinated crosses

    Science.gov (United States)

    Wang, Hui; Matsushita, Michinari; Tomaru, Nobuhiro; Nakagawa, Michiko

    2016-01-01

    Female reproductive success in females versus hermaphrodites has been well documented. However, documenting a potential advantage in male fertility of male versus hermaphrodite individuals in subdioecious species is also essential for understanding the evolutionary pathway toward dioecy from hermaphroditism via gynodioecy. Siring success in terms of fruit set, fruit mass, number of seeds and mean seed mass was compared by hand-pollinated crosses in the subdioecious shrub Eurya japonica. The pollen was from male and hermaphrodite individuals, and the pollen recipients were females and hermaphrodites. Seed quality was also evaluated in terms of seed germination rate, seed germination day and seedling survival. Overall, pollen from males sired more fruits of larger size and more seeds than did pollen from hermaphrodites. The male advantage was observed when pollen recipients were females, whereas no effect was found in hermaphrodite recipients. Pollen from males also produced better quality seeds with higher germination rate and sooner germination day. Although these results could also be explained by a higher pollen load for crosses with male pollen donors, we took care to saturate the stigma regardless of the pollen donor. Therefore, these results suggest that male individuals of E. japonica have advantages in male fertility in terms of both quantity and quality. Our previous studies indicated that females exhibit higher female reproductive success compared with hermaphrodites. Thus, both the female and male functions of hermaphrodites are outperformed by females and males, respectively, raising the possibility that the subdioecious E. japonica at this study site is entering the transitional phase to dioecy along the gynodioecy–dioecy pathway. PMID:27658818

  7. Self-Disclosure Patterns of Maladjusted Male Adolescents.

    Science.gov (United States)

    Paulson, J. M.

    1980-01-01

    Results indicate that maladjusted adolescent males lack significant relationships with a father figure. This extends to males in general. They disclose less about school-related topics and more about peer relationships than do adjusted male adolescents. (Author/BEF)

  8. Genetics Home Reference: CATSPER1-related nonsyndromic male infertility

    Science.gov (United States)

    ... related nonsyndromic male infertility CATSPER1-related nonsyndromic male infertility Enable Javascript to view the expand/collapse boxes. ... All Close All Description CATSPER1 -related nonsyndromic male infertility is a condition that affects the function of ...

  9. An association between the internalization of body image, depressive symptoms and restrictive eating habits among young males.

    Science.gov (United States)

    Fortes, Leonardo de Sousa; Meireles, Juliana Fernandes Filgueiras; Paes, Santiago Tavares; Dias, Fernanda Coelho; Cipriani, Flávia Marcele; Ferreira, Maria Elisa Caputo

    2015-11-01

    The scope of this study was to analyze the relationship between the internalization of body image and depressive symptoms with restrictive eating habits among young males. Three hundred and eighty-three male adolescents, aged between twelve and seventeen, took part in this survey. The "Overall Internalization" and "Athletic Internalization" sub-scales taken from the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3) were used to evaluate the internalization of body images. The Major Depression Inventory (MDI) was used to evaluate depressive symptoms. The "Diet" sub-scale from the Eating Attitudes Test (EAT-26) was used to evaluate restrictive eating habits. The logistic regression findings indicated 2.01 times greater chances of youngsters with a high level of overall internalization adopting restrictive eating habits (Wald = 6.16; p = 0.01) when compared with those with low levels. On the other hand, the regression model found no significant association between "Athletic Internalization" (Wald = 1.16; p = 0.23) and depressive symptoms (Wald = 0.81; p = 0.35) with eating restrictions. The findings made it possible to conclude that only overall internalization was related to eating restrictions among young males.

  10. Critical Skills of Marine Corps Infantry Small Unit Leaders

    Science.gov (United States)

    2008-11-17

    skills, leadership skills, assertiveness, adaptability, and time management skills, were rated by all 6 raters with the maximum possible rating. All...adaptability 5.00 0.00 - - 1.00 p<.05 0.00 p<.05 and Prac. Sig. 47 time management skills 5.00 0.00 - - 1.00 p<.05 0.00 p<.05 and Prac. Sig. 9...tasks efficiently; to keep one’s work space neat and tidy. 14.2 Time Management Skills - To manage one’s own time and the time of others to accomplish

  11. The United States Army Infantry Squad: Year 2015.

    Science.gov (United States)

    1999-06-04

    time is a testament to the selfless service they provide the Army daily. To Kellie, Ashley, and Haley, thank you for the notes, pictures, love , and... astrology . "s Before World War I, the world’s major military powers studied major battles to determine how best to prepare their forces to fight in the

  12. Measurement of Unit Effectiveness in Marine Corps Infantry Battalions. Appendices

    Science.gov (United States)

    1978-10-31

    whose military experience also contributed greatly to the project. Historical work was also undertaken by Dr. Paul Davis, COL, USA(Ret), and Messrs...straight across the island. 3/2 was to secure GREEN BEACH (via land) while 2/8 cleaned out a pocket at the .. Burns- Philp Pier on the left flank of...strong-points near the Burns- Philps Pier. (For 1800 positions, see Map 3.) 2/ 1 (plus 2/2) enlarged the south shore beachhead and made a limited

  13. The Light Infantry Division Regionally Focused for Low Intensity Conflict

    Science.gov (United States)

    1990-06-01

    I.V. Hogg , London: Jane’s Publishing Company Limited, 1986, pp. 92-110. Johnson, W.P., and Russell, E.N. Strategic Studies Project: U.S. Army...Triumph. New York: Penguin Books, 1962. Laquer, Walter. Guerrilla: A Historical and Critical Study. Boston: Little, Brown, 1976. 273 Lincoln, Jennie K

  14. Implications of Integrating Women into the Marine Corps Infantry

    Science.gov (United States)

    2015-12-01

    negative consequences for unit cohesion. This may help explain why some studies of gender integration in the military have found no negative effects of...Backlash Effects for Disconfirming Gender Stereotypes in Organiza- tions,” Research in Organizational Behavior, Vol. 28, 2008, pp. 61–79; Laurie A...Moderates Stereotype Threat Effects on Women’s Math Performance,” Journal of Experimental Social Psychology, Vol. 38, No. 2, 2002, pp. 194–201. Gender

  15. Simulation of Dismounted Infantry Combat in Urban Terrain

    Science.gov (United States)

    1981-09-01

    New Mexico 88002 20. Headquarters, Department of the Army Office of the Deputy Chief of Staff for Operations and Plans ATTN: DA-MO-2D Washington, D. C...20310 21. Commander US Army Concepts and Analysis Agency ATTN: MOCA -WG (LTC Earl Darden) 8120 Woodmont Avenue Bethesda, Maryland 20014 22. Director...Missile Range, New Mexico 88002 25. Commander MICOM ATTN: DRSMI-YC (MAJ Hagewood) Redstone Arsenal, Alabama 35809 26. Director Combat Developments

  16. Bradley Infantry Fighting Vehicle Procedures Guides: Commander and Gunner

    Science.gov (United States)

    1984-02-01

    HATCH SAFETY PIN X _X X X D ENGINE TRANSMISSION OIL X X X D ALL X X S FRONT RING EXTERIOR SIGHT X X S ANTENNA MOUNT X S SHIELD DOOR X X S TURRET LAUNCHER...D-DRIVER G-GUNNER 2 EnrA14S-OTHER , W- E -4 LOCATION SYSTEM EQUIPMENT = P I DRIVER’S COVER X X D EXTERIOR HATCH SAFETY PIN X XX D RAMP X X X D RAMP

  17. Light Infantry in the Defense of Urban Europe.

    Science.gov (United States)

    1986-12-14

    plateau and containing a maze of narrow streets, cul-de-sacs, vaults, caves, and tunnels; as well as an outer, nodern urbin drea. Stone construction was...localizc±d forces and sortie use ..ade of runners and teboj1p~r;t ."’Ive iu en l W𔃾 SciLQ L the tactical situation. 8 Turning to the ongoing Iran

  18. The Operational Employment of the Light Infantry Division.

    Science.gov (United States)

    1986-06-02

    conducted in the latter part of May 1941. The operation, code named MERKUR , represented an initial step by the Germans to gain total control of the...options of seizing Malta or Crete and somewhat unenthusiasticly, issued Operational Directive 28 authorizing Operation Merkur on 25 April 1941.E51 The

  19. The South African Defence Force and Horse Mounted Infantry ...

    African Journals Online (AJOL)

    Jacques

    2003-03-26

    Mar 26, 2003 ... period, its first mounted troops were deployed to the Border region by ... Sergeant Major, in the eyes of the Defence Force, officially the horse was a ... psychology of training, serving to reinforce identification with the horse. As .... and given to horses in trial and control groups to measure the feed's benefit.

  20. Measurement of Unit Effectiveness in Marine Corps Infantry Battalions

    Science.gov (United States)

    1978-10-31

    before taken a drink in his life) or a theoretical framework (money is less important than a happy family life) that orders the data for us...between individuals at mealtime . e Average distance between individuals on the march. . Average distance to flank guards on the march. e Number of

  1. Human Powered Vehicles in Support of Light Infantry Operations

    Science.gov (United States)

    1989-06-02

    E 3. Noise level, 65 decibel maximum desirable, 70 decibel essential, at 50 meters at full engine RPM. M 4. Travel speed: 0 to 12 mph minimun . M 5...to pass, were able to support the bicycle convoys.(1:128) In 1951 Giap started waging long term battles with the French using division size units. In...cannot bomb what you cannot see. The bicyc2e convoys that were destroyed were usually those caught in the general interdiction campaign waged against

  2. Commentary Article THE INFLUENCE OF THE RATEL INFANTRY ...

    African Journals Online (AJOL)

    plt

    the imaginable political, diplomatic, military and social ramifications and ... perspectives, but as Dr Michael Evans of the Australian Defence College, Canberra, observes, “Only a quarter ago, the Southern African region was one of the world's ... total economic, political and military embargoes in the seventies and eighties.

  3. Parametric Simulation of Infantry Tactics and Equipment (Dismounted Star).

    Science.gov (United States)

    1980-06-01

    prepared by General Research Corporation in t November 1974. CARMONETTE is a Ponte Carlo, event sequenced simulation of ground comnat . The original...model was developed by the Research Analysis Corporation in the late 1950’s. The principal activities represented In the model are movement, target...III, 1972. 12. General Research Corporation , OAD-CR-73, CARMONETTE, Volumes I, II. and III, November 1974. 13. Parry, S.H., and Kelleher, E.P

  4. Vulnerable discipline: experiences of male competitive bodybuilders.

    Science.gov (United States)

    Bjørnestad, Jone; Kandal, Øyvind; Anderssen, Norman

    2014-09-01

    The aim was to understand experiences of male competitive bodybuilders from a non-pathologizing perspective. Six male Norwegian competitive bodybuilders were interviewed. The interviews were analysed using a meaning condensation procedure resulting in five themes: being proud of capacity for discipline, seeing a perfectionist attitude as a necessary evil, experiencing recognition within the bodybuilding community, being stigmatized outside the bodybuilding community and going on stage to display a capacity for willpower and discipline. We suggest that bodybuilders may be stigmatized for breaking social norms: by their distinctive appearance, by the way they handle suspected drug use and by challenging gender norms.

  5. Predictors of dominance in male Betta splendens.

    Science.gov (United States)

    Bronstein, P M

    1985-03-01

    The formation of dominance/subordinancy relations in pairs of male Siamese fighting fish was examined in six experiments. Dominant animals typically were those fish that built the largest nests and that attacked an image of a live, displaying male most intensely prior to combat. However, pretest performance on an operant task and reaction to an animal's own mirror image were not useful predictors of subsequent dominance. These findings are consistent with the suggestion that domesticated Bettas have a territorial social strategy that includes both nest-building and fighting behaviors.

  6. Male and Female Differences in Nonconscious Mimicry

    DEFF Research Database (Denmark)

    Lehane, Christine Marie

    2015-01-01

    Previous research on nonconscious mimicry suggests that females mimic their communication partners more often than males. Many studies have investigated the association between mimicry, emotion recognition, and empathy. However, there is a trend in this research area to recruit same-sex samples......, thus neglecting a discussion regarding the role of sex or gender as a moderator of nonconscious mimicry. This article reviews the research on nonconscious mimicry – facial, behavioural, and verbal, in order to identify whether or not there are male and female differences. The results indicate...

  7. Decline in male circumcision in South Korea

    Directory of Open Access Journals (Sweden)

    Kim DaiSik

    2012-12-01

    Full Text Available Abstract Background To investigate the changing circumcision rate in South Korea in the last decade and to propose underlying causes for this change, in the context of the present fluctuating world-wide trends in circumcision. Methods From 2009 to 2011, 3,296 South Korean males (or their parents aged 0–64 years were asked about their circumcision status, their age at circumcision, and their information level regarding circumcision. We employed non-probability sampling considering the sensitive questions on the study theme. Results Currently the age-standardized circumcision rate for South Korean males aged 14–29 is found to be 75.8%. In an earlier study performed in 2002, the rate for the same age group was 86.3%. Of particular interest, males aged 14–16 show a circumcision rate of 56.4%, while the same age group 10 years ago displayed a much higher percentage, at 88.4%. In addition, the extraordinarily high circumcision rate of 95.2% found 10 years ago for the 17–19 age group is now reduced to 74.4%. Interestingly, of the circumcised males, the percentage circumcised in the last decade was only 25.2%; i.e., the majority of the currently circumcised males had undergone the operation prior to 2002, indicating that the actual change in the last decade is far greater. Consistent with this conjecture, the 2002 survey showed that the majority of circumcised males (75.7% had undergone the operation in the decade prior to that point. Focusing on the flagship age group of 14–16, this drop suggests that, considering the population structure of Korean males, approximately one million fewer circumcision operations have been performed in the last decade relative to the case of non-decline. This decline is strongly correlated with the information available through internet, newspapers, lectures, books, and television: within the circumcised population, both the patients and their parents had less prior knowledge regarding circumcision, other than

  8. Involvement of males in promoting reproductive health

    Directory of Open Access Journals (Sweden)

    T.M.M. Maja

    2007-09-01

    Full Text Available At the international conference on Population and Development held in Cairo 1994, specific aspects of reproductive health addressed endorsed among others, were that unwanted pregnancies must always be given the highest priority and that every attempt should be made to eliminate the need for abortion. This paper focused on the involvement of males in promoting reproductive health through prevention of unplanned and unwanted pregnancies. A total of 71 males (48 adults and 23 adolescents were selected conveniently from two health care centres, North of Tshwane, Gauteng province. Structured questionnaires having open and closed questions were used for data collection.

  9. Clinical Trials in Male Hormonal Contraception

    Directory of Open Access Journals (Sweden)

    Nieschlag E

    2011-01-01

    Full Text Available Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical trials concentrate on testosterone combined with norethisterone, desogestrel, etonogestrel or depot-medroxyprogesterone acetate. The first randomized, placebo-controlled clinical trial performed by the pharmaceutical industry demonstrated the effectiveness of a combination of testosterone undecanoate and etonogestrel in suppressing spermatogenesis in volunteers.

  10. Integrative data analysis of male reproductive disorders

    DEFF Research Database (Denmark)

    Edsgard, Stefan Daniel

    During the last decades a decline in male reproductive health has been observed in Nordic countries, and particularly in Denmark. Testicular cancer is the most fatal form of male reproductive disorders, and despite high remission rates it is typically accompanied with infertility. The main topic...... superimposed with established phenomic information. We thereby identified a recurrent CNV at a locus with genes encoding for the relaxin peptide hormones, indicating their potential role in testis function. Paper III presents a genome-wide assocation study on testicular dysgenesis syndrome. We confirmed...

  11. Levels of nutrients in the leaves of twelve genotypes of grape Teores foliares de nutrientes em doze genótipos de videira

    Directory of Open Access Journals (Sweden)

    Almy Junior Cordeiro de Carvalho

    2010-12-01

    Full Text Available The objective of this study was to characterize the levels of mineral nutrients: N, P, K, Ca, Mg, S, Mn, Fe, Zn, Cu, Mo and B of twelve genotypes of grapevine: 'Italy', 'Ruby' , 'Patricia', 'Isabel', 'Redglobe', 'Roberta', 'Kyoho', 'Roman', 'Rosalinda', 'Moscatel de Hamburgo’,' 'Niagara Rosada' and 'UVF 01' in the North of Rio de Janeiro State. The plants were pruinned and fertilized (organic and mineral. The leaf blades were analyzed in two periods of the reproductive cycle of the vine: in full bloom and the beginning of berry ripening (veraison. In this characterization, it was concluded that the leaves reflected the nutritional status of the vine genotypes. The genotypes did not show levels of N below normal, with most genotypes showing normal levels. Neither genotype showed below normal levels of K and P. All genotypes showed levels of Ca below the normal range for all seasons and Mg in the normal range. All genotypes showed normal levels of B.O objetivo deste trabalho foi o de caracterizar o teor de nutrientes minerais: N, P, K, Ca, Mg, S, Mn, Fe, Zn, Cu, Mo e B de doze genótipos de videira: ‘Itália’, ‘Rubi’, ‘Patrícia’, ‘Isabel’, ‘Redglobe’, ‘Roberta’, ‘Kyoho’, ‘Romana’, ‘Rosalinda’, ‘Moscatel de Hamburgo’, ‘Niágara Rosada’ e ‘UVF 01’ na região Norte Fluminense. Realizou-se a poda, seguida de adubação convencional e orgânica e análise do limbo foliar em duas épocas do ciclo reprodutivo da videira: no pleno florescimento e início da maturação das bagas (“veraison”. Nessa caracterização, concluiu-se que o limbo foliar coletado refletiu bem o estado nutricional dos genótipos de videira. Os genótipos não apresentaram níveis de N abaixo do normal, sendo a maioria dos genótipos apresentaram níveis normais. Nenhum genótipo apresentou níveis abaixo do normal de K e P. Todos os genótipos apresentaram níveis de Ca abaixo da faixa normal para as duas épocas amostradas e n

  12. Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment.

    Directory of Open Access Journals (Sweden)

    Jenna B Gillen

    Full Text Available We investigated whether sprint interval training (SIT was a time-efficient exercise strategy to improve insulin sensitivity and other indices of cardiometabolic health to the same extent as traditional moderate-intensity continuous training (MICT. SIT involved 1 minute of intense exercise within a 10-minute time commitment, whereas MICT involved 50 minutes of continuous exercise per session.Sedentary men (27±8y; BMI = 26±6kg/m2 performed three weekly sessions of SIT (n = 9 or MICT (n = 10 for 12 weeks or served as non-training controls (n = 6. SIT involved 3x20-second 'all-out' cycle sprints (~500W interspersed with 2 minutes of cycling at 50W, whereas MICT involved 45 minutes of continuous cycling at ~70% maximal heart rate (~110W. Both protocols involved a 2-minute warm-up and 3-minute cool-down at 50W.Peak oxygen uptake increased after training by 19% in both groups (SIT: 32±7 to 38±8; MICT: 34±6 to 40±8ml/kg/min; p<0.001 for both. Insulin sensitivity index (CSI, determined by intravenous glucose tolerance tests performed before and 72 hours after training, increased similarly after SIT (4.9±2.5 to 7.5±4.7, p = 0.002 and MICT (5.0±3.3 to 6.7±5.0 x 10-4 min-1 [μU/mL]-1, p = 0.013 (p<0.05. Skeletal muscle mitochondrial content also increased similarly after SIT and MICT, as primarily reflected by the maximal activity of citrate synthase (CS; P<0.001. The corresponding changes in the control group were small for VO2peak (p = 0.99, CSI (p = 0.63 and CS (p = 0.97.Twelve weeks of brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men, despite a five-fold lower exercise volume and time commitment.

  13. Electric-dipole-coupled H2O@C60 dimer: Translation-rotation eigenstates from twelve-dimensional quantum calculations

    Science.gov (United States)

    Felker, Peter M.; Bačić, Zlatko

    2017-02-01

    We report on variational solutions to the twelve-dimensional (12D) Schrödinger equation appertaining to the translation-rotation (TR) eigenstates of H2O@C60 dimer, associated with the quantized "rattling" motions of the two encapsulated H2O molecules. Both H2O and C60 moieties are treated as rigid and the cage-cage geometry is taken to be fixed. We consider the TR eigenstates of H2O@C60 monomers in the dimer to be coupled by the electric dipole-dipole interaction between water moieties and develop expressions for computing the matrix elements of that interaction in a dimer basis composed of products of monomer 6D TR eigenstates reported by us recently [P. M. Felker and Z. Bačić, J. Chem. Phys. 144, 201101 (2016)]. We use these expressions to compute TR Hamiltonian matrices of H2O@C60 dimer for two values of the water dipole moment and for various dimer geometries. 12D TR eigenstates of the dimer are then obtained by filter diagonalization. The results reveal two classes of eigenstates, distinguished by the leading order (first or second) at which dipole-dipole coupling contributes to them. The two types of eigenstates differ in the general magnitude of their dipole-induced energy shifts and in the dependence of those shifts on the value of the water dipole moment and on the distance between the H2O@C60 monomers. The dimer results are also found to be markedly insensitive to any change in the orientations of the C60 cages. Finally, the results lend some support for the interpretation that electric dipole-dipole coupling is at least partially responsible for the apparent reduced-symmetry environment experienced by H2O in the powder samples of H2O@C60 [K. S. K. Goh et al., Phys. Chem. Chem. Phys. 16, 21330 (2014)], but only if the water dipole is taken to have a magnitude close to that of free water. The methodology developed in the paper is transferable directly to the calculation of TR eigenstates of larger H2O@C60 assemblies, that will be required for more

  14. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: report of twelve cases and discussion of mechanism of action.

    Science.gov (United States)

    Lee, Bok Y; Al-Waili, Noori; Stubbs, Dean; Wendell, Keith; Butler, Glenn; Al-Waili, Thia; Al-Waili, Ali

    2009-12-06

    Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT) device (EPRT Technologies-USA, Simi Valley, CA) in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30-100%). The patients

  15. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

    Directory of Open Access Journals (Sweden)

    Bok Y. Lee, Noori AL-Waili, Dean Stubbs, Keith Wendell, Glenn Butler, Thia AL-Waili, Ali AL-Waili

    2010-01-01

    Full Text Available Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT device (EPRT Technologies-USA, Simi Valley, CA in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30

  16. What makes a nest-building male successful? Male behavior and female care in penduline tits

    NARCIS (Netherlands)

    Szentirmai, [No Value; Komdeur, J; Szekely, T; Szentirmai, István

    2005-01-01

    Why do females increase parental effort when caring for the offspring of attractive males? First, attractive males may be poor fathers so that their females are compelled to increase their own contribution in order to fledge some young (the partner-compensation hypothesis). Second, females mated to

  17. Bodice Rippers without the Bodice: Ten Male-on-Male Romances for a Core Collection

    Science.gov (United States)

    Thomas, Devon

    2011-01-01

    One of the hottest growing segments of the romance genre is male-on-male (M/M) romance--gay romantic fiction mostly written and read by straight women. Featuring traditional romance conventions, including mistaken identities, star-crossed lovers, and happy endings, these stories show both physical and emotional intimacy between men. M/M builds on…

  18. Self-Concept and Psychological Adjustment Differences Between Self-Identified Male Transexuals and Male Homosexuals

    Science.gov (United States)

    Roback, Howard B.; And Others

    1977-01-01

    Self-concept and adjustment data from anatomical males seeking sexual reassignment surgery were compared with that from a male homosexual group. Findings indicated that the homosexual group had a better self-image and was better adjusted than the sex change group. (Author)

  19. Female qualities in males: vitellogenin synthesis induced by ovary transplants into the male silkworm, Bombyx mori.

    Science.gov (United States)

    Yang, Congwen; Lin, Ying; Shen, Guanwang; Chen, Enxiang; Wang, Yanxia; Luo, Juan; Zhang, Haiyan; Xing, Runmiao; Xia, Qingyou

    2014-10-10

    Female qualities in males are common in vertebrates but have not been extensively reported in insects. Vitellogenin (Vg) is highly expressed in the female fat body and is generally required for the formation of yolk proteins in the insect egg. Vg upregulation is generally regarded as a female quality in female oviparous animals. In this study, we found that Bombyx mori Vg (BmVg) is especially highly expressed in the female pupa. Downregulation of the BmVg gene in the female pupa by RNA interference (RNAi) interfered with egg formation and embryonic development, showing the importance of BmVg in these processes. So, we used BmVg as a biomarker for female qualities in the silkworm. Hematoxylin-eosin staining and immunofluorescence histochemistry showed that ovary transplants induced BmVg synthesis in the male pupa fat body. Ovaries transplanted into male silkworms produced only a few eggs with deformed yolk granules. These results suggested that the amount of BmVg in the male silkworm was insufficient for eggs to undergo complete embryonic development. After 17-beta-estradiol was used to treat male pupae and male pupal fat bodies, BmVg was upregulated in vivo and in vitro. These findings indicated that the male silkworm has innate female qualities that were induced by a transplanted ovary and 17β-estradiol. However, in silkworms, female qualities in males are not as complete as in females.

  20. Sexy males and choosy females on exploded leks: correlates of male attractiveness in the Little Bustard.

    Science.gov (United States)

    Jiguet, Frédéric; Bretagnolle, Vincent

    2014-03-01

    In their choice of mates, females may use alternative tactics, including a comparative assessment of males in a population, using one or several relative preference criteria. Traits involved in female choice should presumably be variable between, but not within males, thus potentially providing reliable cues of male identity and quality for prospecting females. In lekking species, sexual selection is usually intense, and females can freely choose mates. Studying the Little Bustard Tetrax tetrax, a bird with an exploded lek mating system, we first identified male phenotypic traits that showed higher among, than within variation (plumage pattern, display rates and call structure). Among those and other traits (ornaments and their symmetry, body condition, lek spatial organization and territory quality), we identified phenotypic traits that correlated with male attractiveness toward females. At least four phenotypic male traits were correlated with female attraction, i.e. body condition, lek attendance, ornamental symmetry and display rates. Traits related to the initial female attraction on male territory seem to differ from traits related to the decision of females to stay in the territory of attractive males.