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Sample records for twelve eighteen twenty-nine

  1. The Stability of DSM Personality Disorders over Twelve to Eighteen Years

    Science.gov (United States)

    Nestadt, Gerald; Di, Chongzhi; Samuels, J F; Bienvenu, O J; Reti, I M; Costa, P; Eaton, William W; Bandeen-Roche, Karen

    2009-01-01

    Background Stability of personality disorders is assumed in most nomenclatures; however, the evidence for this is limited and inconsistent. The aim of this study is to investigate the stability of DSM-III personality disorders in a community sample of eastern Baltimore residents unselected for treatment. Methods Two hundred ninety four participants were examined on two occasions by psychiatrists using the same standardized examination twelve to eighteen years apart. All the DSM-III criteria for personality disorders were assessed. Item-response analysis was adapted into two approaches to assess the agreement between the personality measures on the two occasions. The first approach estimated stability in the underlying disorder, correcting for error in trait measurement, and the second approach estimated stability in the measured disorder, without correcting for item unreliability. Results Five of the ten personality disorders exhibited moderate stability in individuals: antisocial, avoidant, borderline, histrionic, and schizotypal. Associated estimated ICCs for stability of underlying disorder over time ranged between approximately 0.4 and 0.7–0.8. A sixth disorder, OCPD, exhibited appreciable stability with estimated ICC of approximately 0.2–0.3. Dependent, narcissistic, paranoid, and schizoid disorders were not demonstrably stable. Conclusions The findings suggest that six of the DSM personality disorder constructs themselves are stable, but that specific traits within the DSM categories are both of lesser importance than the constructs themselves and require additional specification. PMID:19656527

  2. Chapter Twenty Nine

    African Journals Online (AJOL)

    User

    (Feminist) women who say women should live together and all that. I say No. ... However, the freedom which mainstream feminism seeks for women deprives ... That is why she criticises Adaku who opts for single motherhood and prostitution,.

  3. Antioxidant potential of brans of twenty-nine red and white rice (Oryza sativa L. varieties of Sri Lanka

    Directory of Open Access Journals (Sweden)

    Walimuni Kanchana Subhashini Mendis Abeysekera

    2017-11-01

    Full Text Available Objective: To evaluate antioxidant properties of brans of twenty-nine red and white rice varieties of Sri Lanka. Methods: Brans of 21 new improved (NI, 2 old improved (OI and 6 traditional red and white rice varieties of Sri Lanka were studied for range of antioxidant properties. The studied antioxidant properties included total polyphenolic content (TPC, ferric reducing antioxidant power (FRAP, oxygen radical absorbance capacity (ORAC, 2,2’-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid (ABTS radical scavenging activity and 1,1-diphenyl- 2-picrylhydrazine (DPPH radical scavenging activity in vitro. Bran of black rice variety from Korea was also studied for the same antioxidant properties for comparison. Results: Results exhibited significantly high ABTS and DPPH radical scavenging activities and 10, 7 and 2.5 fold greater TPC, FRAP and ORAC activities in brans of red rices (BRRs compared to brans of white rices irrespective of NI, OI and traditional rice types. Among BRRs traditional varieties had greater ABTS and DPPH radical scavenging activities and 1.7, 1.3 and 1.2 fold respectively greater TPC, FRAP and ORAC in contrast to NI red rices. Traditional red rice varieties, Kalu Heeneti (TPC and ORAC, Pachchaperumal (TPC and DPPH and Kurulu Thuda (DPPH and OI red rice variety H4 (FRAP exhibited the highest activities for the antioxidant properties studied. Further, these varieties had significantly high activities compared to black rice. Conclusions: In conclusion, BRRs especially traditional red rices had greater antioxidant properties and consumption may be useful in managing various chronic diseases.

  4. Normal Health-Related Quality of Life and Ability to Work Twenty-nine Years After in Situ Arthrodesis for High-Grade Isthmic Spondylolisthesis.

    Science.gov (United States)

    Joelson, Anders; Hedlund, Rune; Frennered, Karin

    2014-06-18

    The purpose of this mixed prospective and retrospective case series was to evaluate the long-term health-related quality of life and physical disability after in situ arthrodesis for high-grade isthmic spondylolisthesis. Thirty-five of forty consecutive patients who had in situ spinal arthrodesis for high-grade isthmic spondylolisthesis at a mean age of fifteen years (range, nine to twenty-five years) completed validated questionnaires (Short Form-36 [SF-36], EuroQol-5 Dimensions [EQ-5D], Zung depression scale, Oswestry disability index [ODI], Million score, and back and leg pain visual analog scale [VAS]) and underwent physical examination twenty-nine years (range, twenty-three to thirty-five years) after surgery. The mean age at the time of follow-up was forty-three years (range, thirty-seven to fifty-one years). In the absence of a formal control group, the scores on the SF-36 and EQ-5D were compared with Swedish normative data. The proportion of patients at work was compared with an age-matched control group derived from official statistics of Sweden. The Million score at the long-term follow-up was compared with the corresponding results at the mid-term follow-up of the same patients at a mean age of twenty-two years. The scores on the SF-36 and EQ-5D were similar to the scores of the general Swedish population. The mean Zung depression scale score was 30 (range, 20 to 52), the mean ODI score was 10 (range, 0 to 34), the mean back pain VAS score was 13 (range, 0 to 72), and the mean leg pain VAS score was 9 (range, 0 to 60). The Million score averaged 28 (range, 0 to 109) and was slightly worsened compared with the score of 19 (range, 0 to 94) at the mid-term follow-up (p = 0.034). The proportion of patients at work was the same as that for the age-matched general Swedish population. Our study shows good outcomes in health-related quality of life, disability, pain, and ability to work at up to twenty-nine years after in situ lumbar spine arthrodesis for high

  5. An assessment of twelve- versus eighteen-month cycles for PWRs

    International Nuclear Information System (INIS)

    Momsen, B.F.; Dale, R.

    1983-01-01

    This paper discusses the technical and economic factors involved in 18-month cycles for Zion pressurized water reactors (PWRs). The technical factors are divided into the factors that define input to the economic analysis and factors that are combined with the economic results in the final decisionmaking process. The economic analysis was performed by using a Present Value of the Revenue Requirements (PVRR) method and a complementary cash flow examination. The PVRR analysis examined total costs associated with both the 12- and 18-month cycles. The only significant technical problem that was identified was the relatively low new fuel enrichment limit of 3.2 w/o U 235 . The economic analysis demonstrated that 18-month cycles yielded significant PVRR savings over the 15-year study period. The economic benefits of 18-month cycles decreased as the fuel cost increased, the operating capacity factor decreased, the refueling outage length decreased, the differential 18-month cycle outage length increased, the replacement power cost decreased, and the escalation rate decreased

  6. The twelve colourful stones

    International Nuclear Information System (INIS)

    Doria, R.M.

    1983-01-01

    A dynamics with twelve colourful stones is created based on the concepts of gauge and colour. It is associated different gauge fields to the same group. A group of gauge invariant Lagrangians is established. A gauge invariant mass term is introduced. The colourful stones physical insight is to be building blocks for quarks and leptons. (Author) [pt

  7. The twelve colourful stones

    International Nuclear Information System (INIS)

    Doria, R.M.

    1984-01-01

    The gauge symmetry is extended. It is associated differents matter and gauge fields to the same group. A group of gauge invariant Lagrangians is established. A gauge invariant mass term is introduced. A massive Yang Mills is obtained. A dynamics with twelve colourful stones is created based on the concepts of gauge and colour. Structures identified as quarks and leptons are generated. A discussion about colour meaning is presented. (Author) [pt

  8. Twelve years at DESY

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    As reported in our previous issue (page 27), on 28 February Volker Soergel stepped down after serving as Chairman of the Board of the DESY Laboratory in Hamburg since January 1981, when the previous chairman, Herwig Schopper, moved to become Director General of CERN. DESY is now headed by Bjorn Wiik. During the twelve years of Soergel's mandate, DESY substantially evolved and progressed. Dominating the landscape was the big HERA electron-proton collider - the world's first - proposed, approved, constructed and commissioned under Soergel's leadership. As well as pioneering electron-proton collisions, HERA also broke new ground in international collaboration. At the approval of the project by the German government, it had already been made clear that both the machine and its experiments had to be built with full international cooperation, using material contributions from foreign institutes. With the difficult task of transforming these requirements into hard reality, Volker Soergel succeeded brilliantly. The 'HERA model', with interested countries pledging contributions in equipment and/or manpower, established a new route to major project involvement. For HERA, the substantial Italian contribution, organized by Antonino Zichichi, was vital to the success of the project

  9. Development of twenty-nine polymorphic microsatellite loci from ...

    Indian Academy of Sciences (India)

    genetic management decisions for artificial propagation populations. ... Genomic DNA for genomic library construction was ..... the research of population dynamics and genetic structure of Cor- ... genotyping errors in microsatellite data. Mol.

  10. Development and characterization of twenty-nine novel polymorphic ...

    Indian Academy of Sciences (India)

    These research areas have long suffered from one of the challenges of system- ..... library of red sea bream (Chrysophrys major) and cross-species amplification. Mol. ... high throughput web application for PCR and sequencing primer design.

  11. Assessment of the protein quality of twenty nine grain amaranth ...

    African Journals Online (AJOL)

    The sum of essential amino acids ranged from 31.22 to 44.88 g/100 g and 60.87 g/100 g total protein in amaranth and soybean, respectively; limited only in tryptophan and leucine for amaranth, and methionine for soybean. Amaranth is a good source of high quality protein and may serve as a nutritive substitute for some ...

  12. 29 CFR 779.508 - Eighteen-year minimum.

    Science.gov (United States)

    2010-07-01

    ... RETAILERS OF GOODS OR SERVICES Other Provisions Which May Affect Retail Enterprises Child Labor Provisions... 29 Labor 3 2010-07-01 2010-07-01 false Eighteen-year minimum. 779.508 Section 779.508 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR STATEMENTS OF GENERAL...

  13. Transanal rectopexy - twelve case studies

    Directory of Open Access Journals (Sweden)

    Rubens Henrique Oleques Fernandes

    2012-06-01

    Full Text Available OBJECTIVES: This study analyzed the results of transanal rectopexy and showed the benefits of this surgical technique. METHOD: Twelve patients were submitted to rectopexy between 1997 and 2011. The surgical technique used was transanal rectopexy, where the mesorectum was fixed to the sacrum with nonabsorbable suture. Three patients had been submitted to previous surgery, two by the Delorme technique and one by the Thiersch technique. RESULTS: Postoperative hospital stay ranged from 1 to 4 days. One patient (8.3% had intraoperative hematoma, which was treated with local compression and antibiotics. One patient (8.3% had residual mucosal prolapse, which was resected. Prolapse recurrence was seen in one case (8.3%. Improved incontinence occurred in 75% of patients and one patient reported obstructed evacuation in the first month after surgery. No death occurred. CONCLUSION: Transanal rectopexy is a simple, low cost technique, which has shown good efficacy in rectal prolapse control.OBJETIVO: O presente estudo analisou os resultados da retopexia pela via transanal e expôs os benefícios desta técnica cirúrgica. MÉTODO: Doze pacientes com prolapso foram operados no período de 1997 a 2011. A técnica cirúrgica usada foi a retopexia transanal, onde o mesorreto foi fixado ao sacro com fio inabsorvível. Três pacientes tinham cirurgia prévia, dois pela técnica de Delorme e um pela técnica de Thiersch. RESULTADOS: A permanência hospitalar pós-operatória variou de 1- 4 dias. Uma paciente (8,3% apresentou hematoma transoperatório que foi tratado com compressão local e antibioticoterapia. Um paciente apresentou prolapso mucoso residual (8,3%, que foi ressecado. Houve recidiva da procidência em um caso (8,3%. A melhora da incontinência ocorreu em 75% dos pacientes e uma paciente apresentou bloqueio evacuatório no primeiro mês após a cirurgia. Não houve mortalidade entre os pacientes operados. CONCLUSÃO: A retopexia transanal é uma t

  14. Peri-prosthetic fractures around tumor endoprostheses: a retrospective analysis of eighteen cases.

    Science.gov (United States)

    Barut, Nicolas; Anract, Philippe; Babinet, Antoine; Biau, David

    2015-09-01

    Tumour hip and knee endoprostheses have become the mainstay for reconstruction of patients with bone tumours. Fixation into host bone has improved over time. However, some patients present with a peri-prosthetic fracture over follow-up. The objective of this study was to analyse the mode of presentation and survival of implant after a peri-prosthetic fracture around a tumour endoprosthesis. Eighteen peri-prosthetic fractures (17 patients) were included. All patients were treated at a tertiary care center. There were 11 (65%) women; the median age at the time of fracture was 38 years old. All implants were cemented and all knee endoprostheses were fixed-hinge. Twelve (67%) fractures occurred after femoral resection and six (33%) fractures after proximal tibial resection. There were three femoral neck fractures (UCS C), three femoral shaft type C fractures, two femoral shaft type B1, one tibial shaft type B2, three tibial shaft type C, three ankle fractures (UCS C) and three patella fractures (UCS F). Two fractures were treated conservatively and 16 were operated on. Only one patient had the implant revised. There were eight (44%) failures over follow-up; none of the conservative treatment failed. The cumulative probability of failure for any reason was 27% (8-52) and 55% (22-79) at five and ten years, respectively. Peri-prosthetic fractures around massive endoprostheses are different from that of standard implants. There are more type C fractures; internal fixation is an attractive option at the time of presentation but the risk of revision over follow-up is high and patients should be informed accordingly.

  15. Mythematics Solving the Twelve Labors of Hercules

    CERN Document Server

    Huber, Michael

    2009-01-01

    How might Hercules, the most famous of the Greek heroes, have used mathematics to complete his astonishing Twelve Labors? From conquering the Nemean Lion and cleaning out the Augean Stables, to capturing the Erymanthean Boar and entering the Underworld to defeat the three-headed dog Cerberus, Hercules and his legend are the inspiration for this book of fun and original math puzzles. While Hercules relied on superhuman strength to accomplish the Twelve Labors, Mythematics shows how math could have helped during his quest. How does Hercules defeat the Lernean Hydra and stop its heads from multip

  16. 78 FR 23827 - Designation of Eighteen Individuals Pursuant to the Sergei Magnitsky Rule of Law Accountability...

    Science.gov (United States)

    2013-04-22

    ... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Eighteen Individuals Pursuant to the Sergei Magnitsky Rule of Law Accountability Act of 2012 AGENCY: Office of Foreign Assets... blocked pursuant to the Sergei Magnitsky Rule of Law Accountability Act of 2012 (Pub. L. 112-208, December...

  17. [Twelve years of liver transplantation in Lausanne].

    Science.gov (United States)

    Mosimann, F; Bettschart, V; Gardaz, J P; Fontolliet, C; Tissot, J D; Meuwly, J Y; Chioléro, R; Gillet, M

    2001-02-01

    From 1988 to June 2000 138 transplantations were performed in 129 adult patients. Actuarial patient and graft survivals have been 80.7% and 75.4% at one year and 67.8% and 63.5% at 10 years. This compares favourably with the statistics of the European Liver Transplant Registry that collected data from more than 30,000 grafts. Over the twelve years of activity, the indications have become more liberal and the techniques have been simplified. The waiting list has therefore grown and some patients are now unfortunately dying before a graft can be found because the number of brain dead donors remains stable. In order to palliate this shortage, older donors are now being accepted even with co-morbidities and/or moderate alterations of the liver function tests. The use of live donors and the split of the best cadaveric grafts for two recipients will also reduce the gap between the demand and the offer.

  18. Twelve Girls' Band' A Modern Miracle of Traditional Music

    Institute of Scientific and Technical Information of China (English)

    YaoZhanxiong

    2004-01-01

    Twelve antique traditional instruments. Twelve spirited, pretty girls. "Twelve Girls' Band" is a traditional instrument orchestra playing well-known folk music in the form of pop. Besides age-old traditional instruments peculiar to China, such as zheng (ancient 21 to 25-stringed plucked instrument), qin (seven-stringed plucked instrument) and erhu (two-stringed Chinese fiddle),

  19. Evaluation of Predicted and Observed Data on Biotransformation of Twenty-Nine Trace Organic Chemicals

    KAUST Repository

    Bertolini, Maria

    2011-01-01

    activated sludge treatment systems. Predominant attenuation processes such as biotransformation and sorption for the target compounds were identified. Biotransformation rate constants determined in this study were used to assess removal of compounds from

  20. Characterisation of twenty-nine (29) accessions of okra (Abelmoschus spp (L.) Moench) in Ghana

    International Nuclear Information System (INIS)

    Ahiakpa, J. K.

    2012-01-01

    A series of investigations were carried out to determine the genetic variability within 29 accessions of okra (Abelmoschus spp (L.) Moench) through characterisation using morphological, biochemical, nutritional and molecular markers. The goal was to obtain information on key traits of okra germplasm relevant to breeders and other researchers towards improvement of the crop. Twenty six (26) indigenous (landraces) and three (3) exotic accessions of okra were collected from eight regions of Ghana and their morpho-agronomic traits were evaluated under field conditions at the Biotechnology and Nuclear Agriculture Research Institute (BNARI) research fields using the International Plant Genetic Research Institute (IPGRI) descriptor list for okra. The 29 exhibited significant variation in all but two quantitative traits studied. Block coefficients of variation were extremely low, implying that results obtained are reliable and repeatable over replications. The 29 accessions were grouped into two major clusters and subsequently into five sub-clusters based on both quantitative and qualitative characters studied. The association between pairs of quantitative yield traits in the okra landraces revealed that flowering and fruiting parameters had significant (P < 0.01) positive associations. Factor scores of 12 characters contributed substantially to total genetic variation among the 29 okra accessions studied. The pattern of clustering did not show distinct association between morpho-agronomic characters and geographic origin of the collections. The output of the Principal Components Analysis (PCA) revealed that different characters contributed differently to total genetic variation. The means of maximum viscosity values for mucilage extracted from the fruits ranged from 53.0 - 366.8bu, with three accessions; DKA (366.8bu), Yeji-Local (329bu) and Amanfrom (316.8bu) recording very high values whilst Cape (53.0bu) had the least maximum viscosity value. There was low level of polymorphism detected among all accessions using inter-simple sequence repeat (ISSR) markers. The accessions, Atomic and Akrave were detected to have originated from a common ancestry. While there was high variability among Okra accessions for the amounts of flavonoids, phenolics and total antioxidant activity in the fresh fruits and the quantities were generally high making okra a good source of natural antioxidants. Ethanol extraction yielded better antioxidant activity than aqueous (water) solvent. The accession, Agric short fruit recorded the highest total flavonoid content (TFC) of 5159.21±12.90μg/g/QE while Cs-Legon had the lowest TFC of 2003.69±2.55μg/g/QE in the ethanol extract. On the other hand, Kortebortor-ASR registered the highest total phenolic content of 63.22 ±3.95μ/g/GAE) while Volta had the lowest TPC of 6.82±0.09μ/g/GAE in the aquous extract. Debo and Kortebortor-ASR recorded the highest (25.83±5.30μ/g/GAE) and lowest (8.0±0.37μ/g/GAE) Total Phenolics Content in the ethanol extract respectively. Nine essential mineral elements (sodium, magnesium, potassium, calcium, bromine, chlorine, copper, aluminium and manganese) were detected among all accessions using Instrumental Neutron Activation Analysis (INAA). There was significant variation in concentrations of these elements found in fresh fruits of the accessions. There were strong positive associations between five pairs of elements contained in the fruits of the accessions of okra.(au)

  1. Isolation and characterization of twenty-nine novel EST-SSR ...

    Indian Academy of Sciences (India)

    All results were adjusted for multiple simul- taneous ... ated from HWE after Bonferroni correction (adjusted P = 0.0017) ... ity test of the designed SSR markers. In the 30 examined. S. undulata samples, the PIC value of the 29 newly devel-.

  2. Evaluation of Predicted and Observed Data on Biotransformation of Twenty-Nine Trace Organic Chemicals

    KAUST Repository

    Bertolini, Maria

    2011-07-01

    Trace organic chemicals present in household products, pesticides, pharmaceuticals and personal care products may have adverse ecotoxicological effects once they are released to the environment. These chemicals are usually transported with the sewage to wastewater treatment facilities, where they might be attenuated depending on the degree of treatment applied prior to discharge to receiving streams. This study evaluates the removal performance of 29 trace organic compounds during two different activated sludge treatment systems. Predominant attenuation processes such as biotransformation and sorption for the target compounds were identified. Biotransformation rate constants determined in this study were used to assess removal of compounds from other treatment plants with similar operational conditions, using data gathered from the literature. The commercial software Catalogic was applied to predict environmental fate of chemicals. The software program consisted of four models able to simulate molecular transformations and to generate degradation trees. In order to assess the accuracy of this program in predicting biotransformation, one biodegradation model is used to contrast predicted degradation pathway with metabolic pathways reported in the literature. The predicted outcome was correct for more than 40 percent of the 29 targeted substances, while 38 percent of the chemicals exhibited some degree of lower agreement between predicted and observed pathways. Percent removal data determined for the two treatment facilities was compared with transformation probability output from Catalogic. About 80 percent of the 29 compounds exhibited a good correlation between probability of transformation of the parent compound and percent removal data from the two treatment plants (R2 = 0.82 and 0.9). Based upon findings for 29 trace organic chemicals regarding removal during activated sludge treatment, attacked fragments present in their structures, predicted data from Catalogic, and peer-reviewed pathways, possible indicator compounds capable of representing the removal of other compounds based on similar structures were identified. In conclusion, nine among the 29 select compounds were grouped into two categories showing similarities between removal, probability of transformation and attacked fragments. If more chemicals are evaluated, this approach could be useful to establish other indicator compounds based on identification of groups of chemicals with similar fate, properties, and structures.

  3. Twenty-nine-month follow-up of a paediatric zirconia dental crown.

    Science.gov (United States)

    Lopez Cazaux, Serena; Hyon, Isabelle; Prud'homme, Tony; Dajean Trutaud, Sylvie

    2017-06-14

    The aim of this paper is to present the long-term follow-up of one paediatric zirconia crown on a deciduous molar. Preformed crowns are part of the armamentarium in paediatric dentistry. In recent years, aesthetic alternatives to preformed metal crowns have been developed, first preveneered crowns and then zirconia crowns. This paper describes the restoration of a primary molar with a zirconia crown (EZ-Pedo, Loomis, California, USA) in an 8-year-old boy. In this clinical case, the protocol for the implementation and maintenance of zirconia crowns is detailed. The patient was followed up for 29 months until the natural exfoliation of his primary molar. The adaptation of the zirconia crown, the gingival health and the wear on the opposing tooth were considered. In this case, the paediatric zirconia crown allowed sustainable functional restoration while restoring a natural appearance of the tooth. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes

    Energy Technology Data Exchange (ETDEWEB)

    Ohm, Robin A.; Feau, Nicolas; Henrissat, Bernard; Schoch, Conrad L.; Horwitz, Benjamin A.; Barry, Kerrie W.; Condon, Bradford J.; Copeland, Alex C.; Dhillon, Braham; Glaser, Fabian; Hesse, Cedar N.; Kosti, Idit; LaButti, Kurt; Lindquist, Erika A.; Lucas, Susan; Salamov, Asaf A.; Bradshaw, Rosie E.; Ciuffetti, Lynda; Hamelin, Richard C.; Kema, Gert H. J.; Lawrence, Christopher; Scott, James A.; Spatafora, Joseph W.; Turgeon, B. Gillian; de Wit, Pierre J. G. M.; Zhong, Shaobin; Goodwin, Stephen B.; Grigoriev, Igor V.

    2013-03-05

    The class of Dothideomycetes is one of the largest and most diverse groups of fungi. Many are plant pathogens and pose a serious threat to agricultural crops that are grown for biofuel, food or feed. Most Dothideomycetes have only a single host plant, and related species can have very diverse hosts. Eighteen genomes of Dothideomycetes have currently been sequenced by the Joint Genome Institute and other sequencing centers. Here we describe the results of comparative analyses of the fungi in this group.

  5. Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Doethideomycetes Fungi

    Energy Technology Data Exchange (ETDEWEB)

    Ohm, Robin A.; Feau, Nicolas; Henrissat, Bernard; Schoch, Conrad L.; Horwitz, Benjamin A.; Barry, Kerrie W.; Condon, Bradford J.; Copeland, Alex C.; Dhillon, Braham; Glaser, Fabien; Hesse, Cedar N.; Kosti, Idit; LaButti, Kurt; Lindquist, Erika A.; Lucas, Susan; Salamov, Asaf A.; Bradshaw, Rosie E.; Ciuffetti, Lynda; Hamelin, Richard C.; Kema, Gert H. J.; Lawrence, Christopher; Scott, James A.; Spatafora, Joseph W.; Turgeon, B. Gillian; de Wit, Pierre J. G. M.; Zhong, Shaobin; Goodwin, Stephen B.; Grigoriev, Igor V.

    2012-03-13

    The class of Dothideomycetes is one of the largest and most diverse groups of fungi. Many are plant pathogens and pose a serious threat to agricultural crops grown for biofuel, food or feed. Most Dothideomycetes have only a single host and related species can have very diverse host plants. Eighteen genomes of Dothideomycetes have currently been sequenced by the Joint Genome Institute and other sequencing centers. Here we describe the results of comparative analyses of the fungi in this group.

  6. Antifouling activity of twelve demosponges from Brazil

    Directory of Open Access Journals (Sweden)

    SM. Ribeiro

    Full Text Available Benthic marine organisms are constantly exposed to fouling, which is harmful to most host species. Thus, the production of secondary metabolites containing antifouling properties is an important ecological advantage for sessile organisms and may also provide leading compounds for the development of antifouling paints. High antifouling potential of sponges has been demonstrated in the Indian and Pacific oceans and in the Caribbean and Mediterranean seas. Brazilian sponges remain understudied concerning antifouling activities. Only two scientific articles reported this activity in sponges of Brazil. The objective of this study was to test crude extracts of twelve species of sponges from Brazil against the attachment of the mussel Perna perna through laboratorial assays, and highlight promising species for future studies. The species Petromica citrina, Amphimedon viridis, Desmapsamma anchorata, Chondrosia sp., Polymastia janeirensis, Tedania ignis, Aplysina fulva, Mycale angulosa, Hymeniacidon heliophila, Dysidea etheria, Tethya rubra, and Tethya maza were frozen and freeze-dried before extraction with acetone or dichloromethane. The crude extract of four species significantly inhibited the attachment of byssus: Tethya rubra (p = 0.0009, Tethya maza (p = 0.0039, Petromica citrina (p = 0.0277, and Hymeniacidon heliophila (p = 0.00003. These species, specially, should be the target of future studies to detail the substances involved in the ability antifouling well as to define its amplitude of action.

  7. Energy and greenhouse effect. Twelve short notes

    International Nuclear Information System (INIS)

    Prevot, Henri

    2013-12-01

    The author proposes twelve brief notes aimed at discussing the reduction of fossil energy consumption in order to reduce CO 2 emissions and to improve the French energy supply security, without any useless expense. These notes address the reason for energy savings, the cost and price of a CO 2 ton, the issue of thermal regulation for buildings (it's not in compliance with the law, and results in higher expenses and increased CO 2 emissions), the introduction of a carbon tax to incite investments for energy saving, the status and health of the CO 2 European market, the support of actions aimed at reducing fossil energy consumption, the fact that bio-heat is ten times more efficient than bio-fuel and that therefore car holders should finance bio-heat, the development of hybrid uses of energy to avoid the difficulty of energy storage, the reduction of CO 2 emissions at low cost (by consuming as much renewable energy as nuclear energy but without wind or photovoltaic energy), the cost of less CO 2 , less fossil energy and less nuclear, and the interest of France to act on its own to reduce CO 2 emissions. The author proposes a brief synthesis of these notes and some proposals regarding thermal regulation for buildings, taxes, the European CO 2 market, the forest biomass, electricity production, and the European and word dimensions of these issues

  8. Seismic fragility of nuclear power plant components (Phase 2): A fragility handbook on eighteen components

    International Nuclear Information System (INIS)

    Bandyopadhyay, K.K.; Hofmayer, C.H.; Kassir, M.K.; Shteyngart, S.

    1991-06-01

    Fragility estimates of seven equipment classes were published in earlier reports. This report presents fragility analysis results from eleven additional equipment categories. The fragility levels are expressed in probabilistic terms. For users' convenience, this concluding report includes a summary of fragility results of all eighteen equipment classes. A set of conversion factors based on judgment is recommended for use of the information for early vintage equipment. The knowledge gained in conducting the Component Fragility Program and similar other programs is expected to provide a new direction for seismic verification and qualification of equipment. 15 refs., 12 tabs

  9. Bacteriological And Clinical Evaluation Of Twelve Cases Of Post ...

    African Journals Online (AJOL)

    Bacteriological And Clinical Evaluation Of Twelve Cases Of Post-Surgical Sepsis Of Odontogenic Tumours At A ... East African Medical Journal ... Intervention: Adequate review of patient\\'s medical history, bacteriological investigations and

  10. Vegetative propagation of twelve fodder tree species indigenous to ...

    African Journals Online (AJOL)

    Vegetative propagation of twelve fodder tree species indigenous to the Sahel, West Africa. Catherine Ky-Dembele, Jules Bayala, Antoine Kalinganire, Fatoumata Tata Traoré, Bréhima Koné, Alain Olivier ...

  11. Eighteen-point abobotulinum toxin a upper face rejuvenation: an eye plastic perspective on 845 subjects.

    Science.gov (United States)

    Kashkouli, Mohsen Bahmani; Amani, Afsaneh; Jamshidian-Tehrani, Mansooreh; Yousefi, Sahar; Jazayeri, Anis Alsadat

    2014-01-01

    To report the method and results of 18-point Abobotulinum toxin A (ABO-BTA, Dysport) upper face rejuvenation on 845 subjects. In a retrospective chart review, all subjects (the first cycle of injection) with ABO-BTA upper face rejuvenation from 2003 to 2009 were included. Excluded were subjects with facial spastic disorders, injection after upper face lifting, and aberrant regeneration of facial nerves. Upper face rejuvenation included 18 points of injection at forehead creases (4), frown lines (5), bunny line (1), crow's feet (4 on both sides), and lower eyelid crease (4 on both sides). They were revisited in 10 to 14 days for assessment of the effects and possible touch-up injection. Demographics, year of injection, topical anesthetic usage, touch-up injection, and adverse effects (AE) were recorded. There were 845 subjects (85.8% women) whose age was below 40 in 49.3%. All but 68 (8%) were happy with the touch-up visit, 10 to 14 days after injection. Touch-up injection was performed in 8% of subjects mainly for the eyebrow asymmetry. AE (22/845, 2.6%) were bruise (15/845, 1.8%), blepharoptosis (3/845, 0.3%), remained eyebrow asymmetry after touch-up injection (2/845, 0.2%), and headache (2/845, 0.2%). They were significantly more in subjects with touch-up injection, younger than 40 years, and in the first and second year of experience (especially for the bruise). Eighteen-point ABO-BTA upper face rejuvenation had a low rate of AE in this series in which majority was bruise at the lateral canthal area. They were significantly more in the first years of experience, subjects younger than 40, and who had touch-up injections.

  12. Nitrogen emissions from broilers measured by mass balance over eighteen consecutive flocks.

    Science.gov (United States)

    Coufal, C D; Chavez, C; Niemeyer, P R; Carey, J B

    2006-03-01

    Emission of nitrogen in the form of ammonia from poultry rearing facilities has been an important topic for the poultry industry because of concerns regarding the effects of ammonia on the environment. Sound scientific data is needed to accurately estimate air emissions from poultry operations. Many factors, such as season of the year, ambient temperature and humidity, bird health, and management practices can influence ammonia volatilization from broiler rearing facilities. Precise results are often difficult to attain from commercial facilities, particularly over long periods of time. Therefore, an experiment was conducted to determine nitrogen loss from broilers in a research facility under conditions simulating commercial production for 18 consecutive flocks. Broilers were reared to 40 to 42 d of age and fed diets obtained from a commercial broiler integrator. New rice hulls were used for litter for the first flock, and the same litter was recycled for all subsequent flocks with caked litter removed between flocks. All birds, feeds, and litter materials entering and leaving the facility were quantified, sampled, and analyzed for total nitrogen content. Nitrogen loss was calculated by the mass balance method in which loss was equal to the difference between the nitrogen inputs and the nitrogen outputs. Nitrogen partitioning as a percentage of inputs averaged 15.29, 6.84, 55.52, 1.27, and 21.08% for litter, caked litter, broiler carcasses, mortalities, and nitrogen loss, respectively, over all eighteen flocks. During the production of 18 flocks of broilers on the same recycled litter, the average nitrogen emission rate was calculated to range from 4.13 to 19.74 g of N/ kg of marketed broiler (grams of nitrogen per kilogram) and averaged 11.07 g of N/kg. Nitrogen loss was significantly (P broiler grow-out facilities varies significantly on a flock-to-flock basis.

  13. 75 FR 68401 - Duncan Smith and Gerald Altizer-Continuance in Control Exemption-Eighteen Thirty Group, LLC and...

    Science.gov (United States)

    2010-11-05

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35436] Duncan Smith and..., LLC Duncan Smith and Gerald Altizer (collectively applicants), noncarrier individuals, have filed a... carriers. Mr. Smith owns 80% of Eighteen Thirty and 75% of Georges Creek. Mr. Altizer owns a 20% interest...

  14. Arius and the Three Hundred and Eighteen Orthodox Fathers in the Ethiopian Tradition

    Directory of Open Access Journals (Sweden)

    Jacques-Noël Pérès

    2015-04-01

    Full Text Available What do today’s Ethiopian Christians think about Arius and what do they think about his theology? Naturally, recent studies concerning this topic are terra incognita to them. Arius continues to represent for them the typical arch-heretic. This author bases his study on his research of the Senkessar (the Ethiopian Synaxarion, the Ethiopian liturgical tradition, a number of other texts, as well as the Ethiopian tradition of sacred art. All this permits him to define the image of Arius in today’s Ethiopian Church. The Ethiopian national epos known as the Kebra Nagast or Glory of the Kings places Arius in the company of Nestorius and Ibo of Edessa. For the Ethiopian church which does not accept the Council of Chalcedon, both of these represent hated dia-physite heretics. By associating Arius with them, he becomes the founder of the dia-physite heresy — a movement which historically occurred only after his time and with which he actually had little or nothing to do. In the Ethiopian Synaxarion, Arius is juxtaposed with such heroes of the Ethiopian faith as Peter, Alexander, and Timothy of Alexandria, Athanasius the Great, and the fathers of the Council of Nicaea. Naturally, here just as in the Kebra, Arius is once again portrayed as the arch-heretic, whose teaching represents a pernicious catastrophe for the Orthodox faith. He is compared with Sabellius, Macedonius, Nestorius, and even Mani. He is demonized to the extent that he is actually called a devil. In the Anaphora of the Three Hundred and Eighteen, Arius is not mentioned by name, but the anaphora in question does contain an attack on his heresy. It would seem that the Ethiopian authors make no attempt to even understand the logic which Arius used to define his position. They simply reject it without discussion. The Ethiopian tradition likewise portrays Arius as a new Judas, pointing out similar details in the way both of these figures met their fi nal end. A particular

  15. Ten colour photometry of twelve Ap-stars

    International Nuclear Information System (INIS)

    Musielok, B.; Lange, D.; Schoeneich, W.; Hildebrandt, G.; Zelwanowa, E.; Hempelmann, A.; Salmanov, G.

    1980-01-01

    Ten-colour photoelectric observations are presented for twelve Ap-stars. Improved ephemeris for seven of them is given. Phase relations between the light curves and line intensity variations are discussed. The problem of the electromagnetic flux conctancy of IOTA Cas is approached from a qualitative point of view. (author)

  16. Education and Development: Twelve Considerations for Transformative Practice

    Science.gov (United States)

    VanBalkom, W. Duffie; Eastham, Sarada

    2011-01-01

    Twelve factors that are essential to consider when embarking on the process of transformative development are examined in the context of international development programming in education and training. Each factor raises a number of questions for the deliberations of policy makers, development practitioners, scholars, international educators,…

  17. Secondary Textbook Review: English, Grades Nine through Twelve.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    This book is intended as a resource for teachers and curriculum developers who select textbooks for secondary English courses. It includes a compilation of 32 factual textbook reviews obtained from the application of a review instrument, which was based on the California "Model Curriculum Standards: Grades Nine through Twelve, English…

  18. Safety of superconducting fusion magnets: twelve problem areas

    International Nuclear Information System (INIS)

    Turner, L.R.

    1979-01-01

    Twelve problem areas of superconducting magnets for fusion reaction are described. These are: quench detection and energy dump, stationary normal region of conductor, current leads, electrical arcing, electrical shorts, conductor joints, forces from unequal currents, eddy current effects, cryostat rupture, vacuum failure, fringing field and instrumentation for safety. Priorities among these areas are suggested

  19. Safety of superconducting fusion magnets: twelve problem areas

    International Nuclear Information System (INIS)

    Turner, L.R.

    1979-01-01

    Twelve problem areas of superconducting magnets for fusion reaction are described. These are: Quench Detection and Energy Dump, Stationary Normal Region of Conductor, Current Leads, Electrical Arcing, Electrical Shorts, Conductor Joints, Forces from Unequal Currents, Eddy Current Effects, Cryostat Rupture, Vacuum Failure, Fringing Field and Instrumentation for Safety. Priorities among these areas are suggested

  20. Eighteen microsatellite loci in Salix arbutifolia (Salicaceae) and cross-species amplification in Salix and Populus species.

    Science.gov (United States)

    Hoshikawa, Takeshi; Kikuchi, Satoshi; Nagamitsu, Teruyoshi; Tomaru, Nobuhiro

    2009-07-01

    Salix arbutifolia is a riparian dioecious tree species that is of conservation concern in Japan because of its highly restricted distribution. Eighteen polymorphic loci of dinucleotide microsatellites were isolated and characterized. Among these, estimates of the expected heterozygosity ranged from 0.350 to 0.879. Cross-species amplification was successful at 9-13 loci among six Salix species and at three loci in one Populus species. © 2009 Blackwell Publishing Ltd.

  1. Twelve years of fireworks market surveillance in France

    OpenAIRE

    Branka , Ruddy

    2012-01-01

    International audience; In the view of market surveillance, more than 4400 fireworks have been taken on the spot by sworn people or bought on the market in France since 1999 for inspection purposes. This paper presents the market surveillance sampling evolution during twelve years, carried out by the PYRO unit of the Accidental Risks Division of INERIS as testing body ; the related measures implemented : additional audits in importer plants, interlaboratory tests for guarantying the reliabili...

  2. Twelve Theses on Reactive Rules for the Web

    OpenAIRE

    Bry, François; Eckert, Michael

    2006-01-01

    Reactivity, the ability to detect and react to events, is an essential functionality in many information systems. In particular, Web systems such as online marketplaces, adaptive (e.g., recommender) sys- tems, and Web services, react to events such as Web page updates or data posted to a server. This article investigates issues of relevance in designing high-level programming languages dedicated to reactivity on the Web. It presents twelve theses on features desira...

  3. Hidden twelve-dimensional super Poincare symmetry in eleven dimensions

    International Nuclear Information System (INIS)

    Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2004-01-01

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional super Poincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven-dimensional superparticle, taken off-shell, we discover a hidden twelve-dimensional super Poincare symmetry that governs the theory

  4. 77 FR 43658 - Designation of Twenty-Nine (29) Individuals Pursuant to Executive Order 13573 of May 18, 2011...

    Science.gov (United States)

    2012-07-25

    ..., Syria; Minister of Tourism (individual) [SYRIA]. 17. AL-SAYYED, Mohammad Abdul-Sattar; DOB 1958; POB Tartus, Syria; Minister of Religious Endowments (individual) [SYRIA]. 18. HABIB, Radwan; DOB 1962; POB...

  5. An Analysis of the Twenty-Nine Capabilities of the Marine Corps Expeditionary Unit (Special Operations Capable)

    National Research Council Canada - National Science Library

    Love, John

    1998-01-01

    ... (Special Operations Capable) (MEU (SOC) to determine their relative validity. The methodology utilizes a multiple criteria decision-making model to determine the relative validity of each MEU (SOC) capability...

  6. Comparison of the spatial patterns of schistosomiasis in Zimbabwe at two points in time, spaced twenty-nine years apart

    DEFF Research Database (Denmark)

    Pedersen, Ulrik Bo; Karagiannis-Voules, Dimitrios-Alexios; Midzi, Nicholas

    2017-01-01

    Temperature, precipitation and humidity are known to be important factors for the development of schistosome parasites as well as their intermediate snail hosts. Climate therefore plays an important role in determining the geographical distribution of schistosomiasis and it is expected that climate......, a Bayesian geostatistical model was fitted to a range of climatic, environmental and other potential risk factors to identify significant predictors that could help us to obtain spatially explicit schistosomiasis risk estimates for Zimbabwe. The observed general downward trend in schistosomiasis prevalence...

  7. Millipedes (Diplopoda of twelve caves in Western Mecsek, Southwest Hungary

    Directory of Open Access Journals (Sweden)

    Angyal, D.

    2013-11-01

    Full Text Available Twelve caves of Western Mecsek, Southwest Hungary were examined between September 2010 and April 2013from the millipede (Diplopoda faunistical point of view. Ten species were found in eight caves, which consistedeutroglophile and troglobiont elements as well. The cave with the most diverse fauna was the Törökpince Sinkhole, while thetwo previously also investigated caves, the Abaligeti Cave and the Mánfai-kőlyuk Cave provided less species, which couldbe related to their advanced touristic and industrial utilization.

  8. Twelve tips for creating an academic teaching portfolio.

    Science.gov (United States)

    Little-Wienert, Kim; Mazziotti, Mark

    2018-01-01

    An academic teaching portfolio is not only a requirement at many academic teaching institutions, but it is also important in a medical educator's growth and development through documentation, reflection, evaluation, and change. Creating an academic portfolio may appear daunting at first but with careful advanced preparation, organized evidence collection of your educational work, proof of scholarship, and thorough documentation of self-reflection and change, you can produce a successful product that accurately represents your educational beliefs, accomplishments, and growth throughout your career. This article provides medical educators with twelve steps for creating a successful academic teaching portfolio.

  9. Safety of superconducting fusion magnets: twelve problem areas

    International Nuclear Information System (INIS)

    Turner, L.R.

    1979-05-01

    Twelve problem areas of superconducting magnets for fusion reaction are described. These are: Quench Detection and Energy Dump, Stationary Normal Region of Conductor, Current Leads, Electrical Arcing, Electrical Shorts, Conductor Joints, Forces from Unequal Currents, Eddy Current Effects, Cryostat Rupture, Vacuum Failure, Fringing Field and Instrumentation for Safety. Each is described under the five categories: Identification and Definition, Possible Safety Effects, Current Practice, Adequacy of Current Practice for Fusion Magnets and Areas Requiring Further Analytical and Experimental Study. Priorities among these areas are suggested; application is made to the Large Coil Project at Oak Ridge National Laboratory

  10. Extended investigation of the twelve-flavor β-function

    Science.gov (United States)

    Fodor, Zoltán; Holland, Kieran; Kuti, Julius; Nógrádi, Dániel; Wong, Chik Him

    2018-04-01

    We report new results from high precision analysis of an important BSM gauge theory with twelve massless fermion flavors in the fundamental representation of the SU(3) color gauge group. The range of the renormalized gauge coupling is extended from our earlier work [1] to probe the existence of an infrared fixed point (IRFP) in the β-function reported at two different locations, originally in [2] and at a new location in [3]. We find no evidence for the IRFP of the β-function in the extended range of the renormalized gauge coupling, in disagreement with [2,3]. New arguments to guard the existence of the IRFP remain unconvincing [4], including recent claims of an IRFP with ten massless fermion flavors [5,6] which we also rule out. Predictions of the recently completed 5-loop QCD β-function for general flavor number are discussed in this context.

  11. Twelve reasons to refuse the nuclear in the MDP

    International Nuclear Information System (INIS)

    Bonduelle, A.

    2000-01-01

    The author presents twelve reasons which show that the nuclear energy has not a place in the MDP Mechanism of Clean Development: a main loophole for the developed countries, the doubtful ''additionality'' of the nuclear, the treaty ratification is more difficult with the nuclear, the domestic energy conservation is more efficient in Europe than the nuclear development, the nuclear white elephants facing the South debts, the technology transfers are doubtful, the developing countries and the sustainable development policies are evicted from the MDP, some options are more powerful in the South, the reactors and transport networks size are unsuited, the absence of democratic control, the nuclear proliferation, the nuclear safety and the wastes. (A.L.B.)

  12. Family functioning and its predictors among disaster bereaved individuals in China: eighteen months after the Wenchuan Earthquake.

    Directory of Open Access Journals (Sweden)

    Xiaoyi Cao

    Full Text Available BACKGROUND: The 2008 Wenchuan earthquake in China resulted in great loss of life and property, and previous studies have focused on psychopathological symptoms in survivors after disasters. This study examined perceived family functioning and its predictors in disaster bereaved individuals eighteen months after the 2008 Wenchuan earthquake. METHODOLOGY/FINDINGS: This was a cross-sectional study of a convenience sample of 264 bereaved individuals. The instruments used in the study included Family APGAR Index, Family Adaptability and Cohesion Evaluation ScaleãÀ, Emotional and Social Loneliness Scale, and a range of items eliciting demographic characteristics and disaster-related variables. The results indicated that the rates of moderate family dysfunction and severe family dysfunction in bereaved individuals were 37.1% and 12.9%, respectively. Less financial loss during the earthquake was a significant predictor for positive family function. Better self-rated health status after the earthquake was significantly related to positive family function, cohesion, and adaptability. Scores on family cohesion and adaptability in bereaved individuals from extended or nuclear families were significantly higher than those from single-parent families. The ability to give birth to another baby of bereaved parents was a significant predictor for positive family function and cohesion. Poorer family function, cohesion and adaptability were significantly related to greater loneliness. CONCLUSIONS/SIGNIFICANCE: This study found a high prevalence of family dysfunction in bereaved individuals eighteen months after the 2008 Wenchuan earthquake. Strategies can be designed to facilitate post-disaster recovery, particularly for the bereaved at high risk for family dysfunction. The study provides useful information for post-disaster rebuilding and relief work.

  13. Commercializing Government-sponsored Innovations: Twelve Successful Buildings Case Studies

    Science.gov (United States)

    Brown, M. A.; Berry, L. G.; Goel, R. K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies.

  14. THE ELM SURVEY. II. TWELVE BINARY WHITE DWARF MERGER SYSTEMS

    International Nuclear Information System (INIS)

    Kilic, Mukremin; Brown, Warren R.; Kenyon, S. J.; Prieto, Carlos Allende; Agueeros, M. A.; Heinke, Craig

    2011-01-01

    We describe new radial velocity and X-ray observations of extremely low-mass white dwarfs (ELM WDs, ∼0.2 M sun ) in the Sloan Digital Sky Survey Data Release 4 and the MMT Hypervelocity Star survey. We identify four new short period binaries, including two merger systems. These observations bring the total number of short period binary systems identified in our survey to 20. No main-sequence or neutron star companions are visible in the available optical photometry, radio, and X-ray data. Thus, the companions are most likely WDs. Twelve of these systems will merge within a Hubble time due to gravitational wave radiation. We have now tripled the number of known merging WD systems. We discuss the characteristics of this merger sample and potential links to underluminous supernovae, extreme helium stars, AM CVn systems, and other merger products. We provide new observational tests of the WD mass-period distribution and cooling models for ELM WDs. We also find evidence for a new formation channel for single low-mass WDs through binary mergers of two lower mass objects.

  15. Comparative analysis of family poultry production in twelve African countries

    International Nuclear Information System (INIS)

    Goodger, W.J.; Bennett, T.B.; Dwinger, R.H.

    2002-01-01

    The purpose of the research was to conduct a survey on family poultry to obtain information on disease prevalence, feeding practices, and the management of poultry housing in twelve African countries. The survey data were collected during both the wet and dry seasons and summarised (average and standard deviation) by country, village/region, season, and survey question. The disease data results show that three (greenish/bloody diarrhoea, swollen head, and coughing) of top four reported symptoms are part of Newcastle disease's presenting signs. Chick mortality was also higher in the wet season, when there is a higher incidence of Newcastle disease. This was also supported by the individual country data in that those countries with high chick mortality data also had low hatchability in the wet season with Egypt being the only exception. The types of housing used for shelter for family poultry was quite variable and presented a challenge to determine the level of cleaning/sanitation to assist in controlling Newcastle disease. On the one hand, a large percentage of households reported never cleaning the poultry house (e.g., Cameroon, Morocco, Mauritius, and Sudan). On the other hand, 34% of the responses to housing type were either trees or other forms of housing that would be difficult to clean i.e., old car, fence, surrounding wall, etc. Obviously, these results should be closely examined when instituting control programs for Newcastle disease. The large variety of available scavenged feed without any data on intake raises the question of how to balance the ration for the flock. Family poultry scientists need to determine a method to estimate intake which could assist in determining what supplementary feed is necessary if any. This challenge may be one of the most important aspects to family poultry management because of the importance of nutrition to poultry production with the added difficulty of providing balanced nutrition in an extensive system. (author)

  16. Commercializing government-sponsored innovations: Twelve successful buildings case studies

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.; Berry, L.G.; Goel, R.K.

    1989-01-01

    This report examines the commercialization and use of R and D results funded by DOE's Office of Buildings and Community Systems (OBCS), an office that is dedicated to improving the energy efficiency of the nation's buildings. Three goals guided the research described in this report: to improve understanding of the factors that hinder or facilitate the transfer of OBCS R and D results, to determine which technology transfer strategies are most effective and under what circumstances each is appropriate, and to document the market penetration and energy savings achieved by successfully-commercialized innovations that have received OBCS support. Twelve successfully-commercialized innovations are discussed here. The methodology employed involved a review of the literature, interviews with innovation program managers and industry personnel, and data collection from secondary sources. Six generic technology transfer strategies are also described. Of these, contracting R and D to industrial partners is found to be the most commonly used strategy in our case studies. The market penetration achieved to date by the innovations studied ranges from less than 1% to 100%. For the three innovations with the highest predicted levels of energy savings (i.e., the flame retention head oil burner, low-E windows, and solid-state ballasts), combined cumulative savings by the year 2000 are likely to approach 2 quads. To date the energy savings for these three innovations have been about 0.2 quads. Our case studies illustrate the important role federal agencies can play in commercializing new technologies. 27 refs., 21 figs., 4 tabs.

  17. Twelve massless flavors and three colors below the conformal window

    International Nuclear Information System (INIS)

    Fodor, Zoltan; Holland, Kieran; Kuti, Julius; Nogradi, Daniel; Schroeder, Chris

    2011-01-01

    We report new results for a frequently discussed gauge theory with twelve fermion flavors in the fundamental representation of the SU(3) color gauge group. The model, controversial with respect to its conformality, is important in non-perturbative studies searching for a viable composite Higgs mechanism beyond the Standard Model (BSM). In comparison with earlier work, our new simulations apply larger volumes and probe deeper in fermion and pion masses toward the chiral limit. Investigating the controversy, we subject the model to opposite hypotheses with respect to the conformal window. In the first hypothesis, below the conformal window, we test chiral symmetry breaking (χSB) with its Goldstone spectrum, F π , the χSB condensate, and several composite hadron states as analytic functions of the fermion mass when varied in a limited range with our best effort to control finite volume effects. In the second test, for the alternate hypothesis inside the conformal window, we probe conformal behavior driven by a single anomalous mass dimension under the assumption of unbroken chiral symmetry at vanishing fermion mass. Our results at fixed gauge coupling, based on the assumptions of the two hypotheses we define, show low level of confidence in the conformal scenario with leading order scaling analysis. Relaxing the important assumption of leading mass-deformed conformality with its conformal finite size scaling would require added theoretical understanding of the scaling violation terms in the conformal analysis and a comprehensive test of its effects on the confidence level of the fits. Results for the running coupling, based on the force between static sources, and preliminary indications for the finite temperature transition are also presented. Staggered lattice fermions with stout-suppressed taste breaking are used throughout the simulations.

  18. Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families

    Directory of Open Access Journals (Sweden)

    LILIAN JARA

    2004-01-01

    Full Text Available BRCA1 gene mutations account for nearly all families with multiple cases of both early onset breast and/or ovarian cancer and about 30% of hereditary breast cancer. Although to date more than 1,237 distinct mutations, polymorphisms, and variants have been described, several mutations have been found to be recurrent in this gene. We have analyzed 63 Chilean breast/ovarian cancer families for eighteen frequent BRCA1 mutations. The analysis of the five exons and two introns in which these mutations are located was made using mismatch PCR assay, ASO hybridization assay, restriction fragment analysis, allele specific PCR assay and direct sequentiation techniques. Two BRCA1 mutations (185delAG and C61G and one variant of unknown significance (E1250K were found in four of these families. Also, a new mutation (4185delCAAG and one previously described polymorphism (E1038G were found in two other families. The 185delAG was found in a 3.17 % of the families and the others were present only in one of the families of this cohort. Therefore these mutations are not prominent in the Chilean population. The variant of unknown significance and the polymorphism detected could represent a founder effect of Spanish origin

  19. “To Sing with the Spirit:” Psalms, Hymns and the Spirituality of Late Eighteen Century American Presbyterians

    Directory of Open Access Journals (Sweden)

    William Harrison Taylor

    2013-12-01

    Full Text Available This paper contends that the contemporary discussion among theologians regarding the relationship between theology and spirituality can offer new insight into the eighteenth century religious world. This theological discussion has wrestled with, among other things, the questions of whether theology and spirituality are mutually exclusive and what exactly their relationship looks like. Resoundingly, theologians such as Alister McGrath, J. I. Packer, and Sandra Schneiders have concluded that any separation of the two represents a false dichotomy within Christianity. Accordingly, Christians are called to “the quest for a fulfilled and authentic Christian existence, involving the bringing together of the fundamental ideas of Christianity and the whole experience of living on the basis of, and within, the scope of the Christian faith.” Sound theology, then, necessitates living by the Spirit and vice versa. The benefit of this theological position for religious history lies in its reevaluation of the common categorization of Christians as either theologically or spiritually focused. By heeding the call of contemporary theologians and blurring these lines of distinction, historians can afford eighteen century American Christians the chance to better define themselves. Considered in this light, the actions of the Presbyterians, for instance, are freed from the manipulative “social control” framework as one of the “establishmentarian” churches. Instead, the Presbyterians reveal characteristics generally reserved for the democratically charged “sectarians,” such as a robust spiritual life compelled by music.

  20. Radiographic and 2-D echocardiographic findings in eighteen cats experimentally exposed to D. immitis via mosquito bites

    International Nuclear Information System (INIS)

    Selcer, B.A.; Newell, S.M.; Mansour, A.E.; McCall, J.W.

    1996-01-01

    Eighteen cats were exposed to Dirofilaria immitis infected mosquitoes. Thoracic radiography was performed prior to exposure and at 5, 7, and 9 month intervals following exposure. Immunologic testing for adult heartworm antigen was performed on days 168, 195, 210, 224, 237, 254 and 271 post infection. Necropsies were performed on all cats. Adult heartworms were found in 61% of the exposed cats. Radiographic findings in heartworm positive cats included bronchointerstitial lung disease, lobar pulmonary arterial enlargement and pulmonary hyperinflation. In most heartworm positive cats, lobar arterial enlargement resolved as the disease progressed while pulmonary hyperinflation progressively became more common. Pulmonary patterns in heartworm positive cats remained abnormal throughout the study while abnormal pulmonary patterns resolved in over 50% of the heartworm negative cats. Cardiomegaly was seen in less than 50% of the cats with adult heartworms at necropsy. This study suggests that the radiographic appearance of heartworm disease is variable and radiographic changes are dependent on the time post infection at which cats are evaluated. Echocardiographic examinations were randomly performed on 16 of 18 cats. Heartworms were identified in 7 cats. No false positive identifications were made. Persistent pulmonary disease accompanied by resolving vascular disease in heartworm cats with pulmonary hyperinflation may be difficult to distinguish from cats with feline allergic lung. Echocardiograms may be helpful in identifying adult heartworms in cats in which the radiographic signs or immunodiagnostic data are insufficient to provide a diagnosis

  1. An appraisal of eighteen commonly consumed edible plants as functional food based on their antioxidant and starch hydrolase inhibitory activities.

    Science.gov (United States)

    Lee, Yian Hoon; Choo, Candy; Watawana, Mindani I; Jayawardena, Nilakshi; Waisundara, Viduranga Y

    2015-11-01

    Eighteen edible plants were assessed for their antioxidant potential based on oxygen radical absorbance capacity (ORAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, total phenolics, vitamin C content and various lipophilic antioxidants. The inhibitory activities of the plant extracts against the enzymatic activities of α-amylase and α-glucosidase were also evaluated. The antioxidant and starch hydrolase activities of the plants varied widely across a single batch of analysis. The ORAC and DPPH radical scavenging EC50 values varied between 298 and 1984 Trolox equivalents g(-1) fresh weight and between 91 and 533 mg kg(-1) fresh weight, respectively. The total phenolics and vitamin C contents varied between 32 and 125 mg gallic acid equivalents g(-1) fresh weight and between 96 and 285 µg g(-1) fresh weight, respectively. All the plants contained neoxanthin, violaxanthin, and α- and β-carotene in varying amounts. Coccinia grandis, Asparagus racemosus, Costus speciosus, Amaranthus viridis and Annona muricata displayed the highest inhibitory activities against starch hydrolases. They were the most efficient against the breakdown of seven starches exposed to the two enzymes as well. Overall, the edible plants were observed to display a high antioxidant potential with starch hydrolase inhibitory properties, which were beneficial in their being recognized as functional food. © 2014 Society of Chemical Industry.

  2. Eighteen-Year Cryopreservation Does Not Negatively Affect the Pluripotency of Human Embryos: Evidence from Embryonic Stem Cell Derivation

    Science.gov (United States)

    Rungsiwiwut, Ruttachuk; Numchaisrika, Pranee; Ahnonkitpanit, Vichuda; Isarasena, Nipan; Virutamasen, Pramuan

    2012-01-01

    Abstract Human embryonic stem (hES) cells are considered to be a potential source for the therapy of human diseases, drug screening, and the study of developmental biology. In the present study, we successfully derived hES cell lines from blastocysts developed from frozen and fresh embryos. Seventeen- to eighteen-year-old frozen embryos were thawed, cultured to the blastocyst stage, and induced to form hES cells using human foreskin fibroblasts. The Chula2.hES cell line and the Chula4.hES and Chula5.hES cell lines were derived from blastocysts developed from frozen and fresh embryos, respectively. The cell lines expressed pluripotent markers, including alkaline phosphatase (AP), Oct3/4, stage-specific embryonic antigen (SSEA)-4, and tumor recognition antigen (TRA)-1-60 and TRA-1-81 as detected with immunocytochemistry. The real-time polymerase chain reaction (RT-PCR) results showed that the cell lines expressed pluripotent genes, including OCT3/4, SOX2, NANOG, UTF, LIN28, REX1, NODAL, and E-Cadherin. In addition, the telomerase activities of the cell lines were higher than in the fibroblast cells. Moreover, the cell lines differentiated into all three germ layers both in vitro and in vivo. The cell lines had distinct identities, as revealed with DNA fingerprinting, and maintained their normal karyotype after a long-term culture. This study is the first to report the successful derivation of hES cell lines in Thailand and that frozen embryos maintained their pluripotency similar to fresh embryos, as shown by the success of hES cell derivation, even after years of cryopreservation. Therefore, embryos from prolonged cryopreservation could be an alternative source for embryonic stem cell research. PMID:23514952

  3. An eighteen year experience of differentiated thyroid carcinoma treatment with 131 radioiodine at the Military Hospital Nuclear Medicine Department

    Energy Technology Data Exchange (ETDEWEB)

    Jofre, M J; Sierralta, M P [Military Hospital Nuclear Medicine Department, Santiago (Chile); Del Campo, G; Ide, A; Wiener, R [Department of Endocrinology of the Military Hospital, Santiago (Chile)

    2002-09-01

    An eighteen year experience of differentiated thyroid carcinoma treatment with 131 radioiodine at the Military Hospital Nuclear Medicine Department. Since the beginning of Nuclear Medicine, the thyroid gland has been an important subject for study. In the fifties, the complimentary use of 131 radioiodine after differentiated thyroid carcinoma (DTC) surgery was postulated. The aim of the study was to analyze our experience of the management of patients with DTC. Material and methods: An 18-year retrospective analysis was made including 109 patients with previous diagnosis of DTC, 90 % females, mean age 47 +/- 17 y.o. (range: 19-85 y.o). Tumoral histology was 67 % papillary, 28 % follicular and 5% non-determined in the medical record. First doses of 131 radioiodine were between 50 and 200 mCi. In all, 156 radioiodine doses were given and 6 patients received 4 doses or more, with total doses between 300 and 570 mCi. Results: The distribution of first and total radioiodine doses is presented in the table below. Of the group of patients who received a first radioiodine dose of less than 100 mCi post surgery, 79% were treated before 1990. Those who received 150mCi or more had cervical ganglionar compromise, trachea invasion or subtotal thyroidectomy. In 50% of the patients who received 4 or more doses, the first two doses were 50 mCi. It is important to mention that there was one patient who received 8 radioiodine doses in 4 years , seven of them were 50 mCi ( total dose 438 mCi). This patient presented trachea and larynx invasion in the early stages, with a persistent focus in the left supraclavicular region. She later developed pulmonary fibrosis, for which she was treated with complimentary radiotherapy (30 Gy), before dying. Distribution of radioiodine doses is presented. Conclusion: It is important to emphasize the validity of a first 131 radioiodine dose after surgery of DTC patients of 100 mCi or more, to obtain the ablation of the remaining thyroid tissue. This

  4. An eighteen year experience of differentiated thyroid carcinoma treatment with 131 radioiodine at the Military Hospital Nuclear Medicine Department

    International Nuclear Information System (INIS)

    Jofre, M.J.; Sierralta, M.P.; Del Campo, G.; Ide, A.; Wiener, R.

    2002-01-01

    An eighteen year experience of differentiated thyroid carcinoma treatment with 131 radioiodine at the Military Hospital Nuclear Medicine Department. Since the beginning of Nuclear Medicine, the thyroid gland has been an important subject for study. In the fifties, the complimentary use of 131 radioiodine after differentiated thyroid carcinoma (DTC) surgery was postulated. The aim of the study was to analyze our experience of the management of patients with DTC. Material and methods: An 18-year retrospective analysis was made including 109 patients with previous diagnosis of DTC, 90 % females, mean age 47 +/- 17 y.o. (range: 19-85 y.o). Tumoral histology was 67 % papillary, 28 % follicular and 5% non-determined in the medical record. First doses of 131 radioiodine were between 50 and 200 mCi. In all, 156 radioiodine doses were given and 6 patients received 4 doses or more, with total doses between 300 and 570 mCi. Results: The distribution of first and total radioiodine doses is presented in the table below. Of the group of patients who received a first radioiodine dose of less than 100 mCi post surgery, 79% were treated before 1990. Those who received 150mCi or more had cervical ganglionar compromise, trachea invasion or subtotal thyroidectomy. In 50% of the patients who received 4 or more doses, the first two doses were 50 mCi. It is important to mention that there was one patient who received 8 radioiodine doses in 4 years , seven of them were 50 mCi ( total dose 438 mCi). This patient presented trachea and larynx invasion in the early stages, with a persistent focus in the left supraclavicular region. She later developed pulmonary fibrosis, for which she was treated with complimentary radiotherapy (30 Gy), before dying. Distribution of radioiodine doses is presented. Conclusion: It is important to emphasize the validity of a first 131 radioiodine dose after surgery of DTC patients of 100 mCi or more, to obtain the ablation of the remaining thyroid tissue. This

  5. Análise do pólen em dezoito cultivares de macieira Pollen analysis of eighteen apple cultivars

    Directory of Open Access Journals (Sweden)

    Fernando Antonio Campo Dall'Orto

    1985-01-01

    Full Text Available Como subsídio essencial ao projeto de melhoramento genético da macieira (Malus spp. por hibridação e ao conhecimento da polinização natural nas condições do Estado de São Paulo, efetuaram-se estudos sobre a quantidade e a viabilidade do pólen existente em dezoito cultivares de maior interesse no momento. Constatou-se que, entre os cultivares mais utilizados nos cruzamentos, Anna, Brasil, Dulcina, Ein Shemer, Gala, Rainha e Valinhense, juntamente com as novas seleções - IAC 170-1 e IAC 570-38 - foram os que se apresentaram mais ricos de pólen, com número superior a 50.000 grãos por flor. Quanto à viabilidade polínica desse material estudado, a germinação situou-se em níveis bastante satisfatórios - quase sempre maior que 50% - mesmo quando se armazenou o pólen por um período de 70 dias, em ambiente frio (-1ºC em dessecadores.Aiming to find out variations in pollen quantity and viability in eighteen apple cultivars, analysis of "in vitro" germination was performed to contribute - as a parameter for genetic breeding by hybridization and as a pollination basis. The apple cultivars or selections recommended for commercial planting, at the mild climate conditions prevailing in the State of São Paulo, Brasil, and most utilized in crosses, are nowadays the following: Anna, Brasil, Dulcina, Ein Shemer, Gala, Rainha, Valinhense, IAC 170-1 and IAC 570-38. These cultivars presented more than 50 thousand pollen grains per one flower. The germination index observed (also an indicator of pollen viability was higher than 50 percent in great number of materials, indicating that the pollen of the apple plant, well prepared, can be stored in a cold and dry environment (a desiccator at -1ºC during a period of about 70 days.

  6. Oil fatty acid composition of eighteen Mediterranean olive varieties cultivated under the arid conditions of Boughrara (southern Tunisia

    Directory of Open Access Journals (Sweden)

    Zarrouk, Mokhtar

    2009-12-01

    Full Text Available In this study, eighteen olive varieties, originating from Spain, France, Italy, Greece and Algeria, and maintained at the olive experimental station of Boughrara (arid region of Tunisia were evaluated for their oil yield and fatty acid composition. The analysis of variance revealed significant differences among varieties for all traits (p En este estudio, dieciocho variedades de aceituna procedentes de España, de Francia, de Italia, de Grecia y de Argelia, cultivadas en la estación experimental del olivo de Boughrara (región árida de Túnez, fueron evaluadas para el rendimiento en aceite y la composición de ácidos grasos. El análisis de la varianza mostró diferencias significativas entre todas las variedades (p < 0.01. El análisis de “clusters” jerárquico clasificó las variedades en tres grandes grupos. El primer grupo incluía un subgrupo compuesto por siete variedades de aceituna Changlot Real, Koroneiki, Verdial de Vélez- Málaga, Coratina, Lechín de Granada, Cornezuelo y Leccino, que se caracterizan por su alto rendimiento en aceite, alto contenido en oleico y bajo contenido en ácidos palmítico y linoleico. Las composiciones de ácidos grasos de aceites provenientes de estas variedades se conforman con estándares internacionales y son mejores si las comparamos con la de Chemlali (el cultivo más abundante en Túnez. Finalmente, los ácidos grasos mayoritarios (palmítico (C16:0, oleico (C18:1 y linoleico (C18:2 de nueve de los aceites de oliva virgen estudiados fueron comparados con los de las mismas variedades cultivadas en sus áreas originarias. A excepción de los aceites Koroneiki y Olivière que mostraron una composición de ácidos grasos inalterable y del aceite Cornezuelo en el que se observó un aumento del nivel de ácido oleico y un descenso del nivel de ácido linoleico, la mayoría de los aceites mostró disminución de ácido oleico y aumento de los porcentajes de ácido palmítico y linoleico, compar

  7. Chapter Twelve

    African Journals Online (AJOL)

    User

    okada na obere jenareto ai passi mai nebo·. 17 ... Oluchukwu Micro-Finance Bank gbasara aka inyere ndi 10. Mmadu aka n'uzo di .... Nigeria· This in no small measure has been helping unemployed people, graduates ... Even in the transport sector people have been empowered to be self reliant· This could be seen in the ...

  8. Twenty-nine years of development in planted cherrybark oak-sweetgum mixtures: implications for future mixed-species hardwood plantations

    Science.gov (United States)

    Brian Roy Lockhart; Andrew W. Ezell; John D. Hodges; Wayne K. Clatterbuck

    2012-01-01

    Results from a long-term planted mixture of cherrybark oak (Quercus pagoda Raf.) and sweetgum (Liquidambar styraciflua L.) showed sweetgum taller in height and larger in diameter than cherrybark oak early in plantation development. By age 17, cherrybark oak was similar in height and diameter with sweetgum and by age 21 was taller...

  9. “History, Theory and Ethics of Medicine”: The Last Ten Years. A Survey of Course Content, Methods and Structural Preconditions at Twenty-nine German Medical Faculties

    Science.gov (United States)

    Schildmann, Jan; Bruns, Florian; Hess, Volker; Vollmann, Jochen

    2017-01-01

    Objective: “History, Theory, Ethics of Medicine” (German: “Geschichte, Theorie, Ethik der Medizin”, abbreviation: GTE) forms part of the obligatory curriculum for medical students in Germany since the winter semester 2003/2004. This paper presents the results of a national survey on the contents, methods and framework of GTE teaching. Methods: Semi-structured questionnaire dispatched in July 2014 to 38 institutions responsible for GTE teaching. Descriptive analysis of quantitative data and content analysis of free-text answers. Results: It was possible to collect data from 29 institutes responsible for GTE teaching (response: 76%). There is at least one professorial chair for GTE in 19 faculties; two professorial chairs or professorships remained vacant at the time of the survey. The number of students taught per academic year ranges from 350. Teaching in GTE comprises an average of 2.18 hours per week per semester (min: 1, max: 6). Teaching in GTE is proportionally distributed according to an arithmetic average as follows: history: 35.4%, theory 14.7% and ethics 49.9%. Written learning objectives were formulated for GTE in 24 faculties. The preferred themes of teaching in history, theory or ethics which according to respondents should be taught comprise a broad spectrum and vary. Teaching in ethics (79 from a max. of 81 possible points) is, when compared to history (61/81) and theory (53/81), attributed the most significance for the training of medical doctors. Conclusion: 10 years after the introduction of GTE the number of students and the personnel resources available at the institutions vary considerably. In light of the differences regarding the content elicited in this study the pros and cons of heterogeneity in GTE should be discussed. PMID:28584871

  10. "History, Theory and Ethics of Medicine": The Last Ten Years. A Survey of Course Content, Methods and Structural Preconditions at Twenty-nine German Medical Faculties.

    Science.gov (United States)

    Schildmann, Jan; Bruns, Florian; Hess, Volker; Vollmann, Jochen

    2017-01-01

    Objective: "History, Theory, Ethics of Medicine" (German: "Geschichte, Theorie, Ethik der Medizin", abbreviation: GTE) forms part of the obligatory curriculum for medical students in Germany since the winter semester 2003/2004. This paper presents the results of a national survey on the contents, methods and framework of GTE teaching. Methods: Semi-structured questionnaire dispatched in July 2014 to 38 institutions responsible for GTE teaching. Descriptive analysis of quantitative data and content analysis of free-text answers. Results: It was possible to collect data from 29 institutes responsible for GTE teaching (response: 76%). There is at least one professorial chair for GTE in 19 faculties; two professorial chairs or professorships remained vacant at the time of the survey. The number of students taught per academic year ranges from 350. Teaching in GTE comprises an average of 2.18 hours per week per semester (min: 1, max: 6). Teaching in GTE is proportionally distributed according to an arithmetic average as follows: history: 35.4%, theory 14.7% and ethics 49.9%. Written learning objectives were formulated for GTE in 24 faculties. The preferred themes of teaching in history, theory or ethics which according to respondents should be taught comprise a broad spectrum and vary. Teaching in ethics (79 from a max. of 81 possible points) is, when compared to history (61/81) and theory (53/81), attributed the most significance for the training of medical doctors. Conclusion: 10 years after the introduction of GTE the number of students and the personnel resources available at the institutions vary considerably. In light of the differences regarding the content elicited in this study the pros and cons of heterogeneity in GTE should be discussed.

  11. Who should do what in environmental management? Twelve principles for allocating responsibilities

    NARCIS (Netherlands)

    Mostert, E.

    2015-01-01

    In environmental management there is often discussion on the allocation of responsibilities. Such discussions can continue for a long time and can form an obstacle for effective action. In this article twelve normative principles for the allocation of responsibilities are identified, coming from

  12. Key lessons: Twelve factors critical to the success of WDM at the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    English · Français ... Key lessons: Twelve factors critical to the success of WDM at the policy and at the operational levels ... from slums in central New Delhi to the city's desolate periphery face daily indignities and danger as they collect water o.

  13. Peucedanum ostruthium (L. Koch: Morphological and phytochemical variability of twelve accessions from the Swiss alpine region

    Directory of Open Access Journals (Sweden)

    McCardell, Jessica Heather

    2016-07-01

    Full Text Available Ostruthin, a natural bioactive compound mainly occurring in the roots of Peucedanum ostruthium, is the focus of this study. P. ostruthium was collected from twelve locations in the Swiss alpine region and reared in an experimental field, subdivided into twelve lots over two years. In the spring and fall, a portion of each of the twelve accessions was harvested and separated into above and below ground plant parts. The dried plants were then extracted with 60 % ethanol using accelerated solvent extraction (ASE and analyzed using high pressure liquid chromatography (HPLC.The above and below ground plant parts were then analyzed concerning their dry matter yield (DMY, their ostruthin concentration and their ostruthin yield. Focusing on ostruthin, it was found that the below ground plant parts harvested in the fall rendered the highest ostruthin yield. Furthermore, a variability concerning ostruthin among the twelve accessions was found. This variability among the accessions is of interest with regards to a breeding program used to develop a cultivar with a high ostruthin yield.

  14. Portrayal of Life Form in Selected Biographies for Children Eight to Twelve Years of Age.

    Science.gov (United States)

    Koch, Shirley Lois

    This study describes and analyzes, in a critical literary manner, selected biographies for children eight to twelve years of age. Biographies of Jane Addams, Cesar Chavez, Mohandas Gandhi, Toyohiko Kagawa, Martin Luther King, Jr., and Albert Schweitzer are viewed from the perspective of a literary criterion based on the principles of design to…

  15. Isolation and characterization of twelve microsatellite loci for the Japanese Devilray (Mobula japanica)

    NARCIS (Netherlands)

    Poortvliet, Marloes; Galvan-Magana, Felipe; Bernardi, Giacomo; Croll, Donald A.; Olsen, Jeanine L.

    2011-01-01

    Twelve polymorphic microsatellites loci were characterized for Mobula japanica (Japanese Devilray) using an enrichment protocol. All but two loci were in Hardy-Weinberg equilibrium with no evidence of linkage disequilibrium or null-alleles for a sample of 40 individuals from two populations. The

  16. Premarital sex in the last twelve months and its predictors among ...

    African Journals Online (AJOL)

    Background: Premarital sex increases the risk of unintended pregnancy and sexually transmitted infections including HIV if unprotected and contraception is not used. Thus, the objective of this study was to assess premarital sex in the last twelve months and its predictors among regular undergraduate students of Wollega ...

  17. The effects of planting density and cultural intensity on loblolly pine crown characteristics at age twelve

    Science.gov (United States)

    Madison Akers; Michael Kane; Robert Teskey; Richard Daniels; Dehai Zhao; Santosh Subedi

    2012-01-01

    Twelve-year old loblolly pine (Pinus taeda L.) stands were analyzed for the effects of planting density and cultural intensity on tree and crown attributes. Four study installations were located in the Piedmont and Upper Coastal Plain regions of the U.S. South. The treatments included six planting densities (740, 1480, 2220, 2960, 3700, 4440 trees...

  18. Vitamin and mineral intake of twelve adolescent male Kalenjin runners in western Kenya

    DEFF Research Database (Denmark)

    Christensen, Dirk Lund; Jakobsen, Jette; Friis, H

    2005-01-01

    runners was carried out to determine their micronutrient intake. MAIN OUTCOME MEASURES: Over a two-week period, samples of the main eaten food were collected for analysis of micronutrient distribution and a daily 24 recall interview performed to determine additional food intake. RESULTS: The estimated...... mg, 1309 microg, and 79 microg, respectively. CONCLUSION: Total daily micronutrient intake of the twelve Kalenjin runners was far from adequate compared to FAO/WHO daily recommended and suggested adequate intake....

  19. A Hidden Twelve-Dimensional SuperPoincare Symmetry In Eleven Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Bars, Itzhak; Deliduman, Cemsinan; Pasqua, Andrea; Zumino, Bruno

    2003-12-13

    First, we review a result in our previous paper, of how a ten-dimensional superparticle, taken off-shell, has a hidden eleven-dimensional superPoincare symmetry. Then, we show that the physical sector is defined by three first-class constraints which preserve the full eleven-dimensional symmetry. Applying the same concepts to the eleven dimensional superparticle, taken off-shell, we discover a hidden twelve dimensional superPoincare symmetry that governs the theory.

  20. Morphology of the spermathecae of twelve species of Triatominae (Hemiptera, Reduviidae) vectors of Chagas disease.

    Science.gov (United States)

    Nascimento, Juliana Damieli; Ribeiro, Aline Rimoldi; Almeida, Larissa Aguiar; de Oliveira, Jader; Mendonça, Vagner José; Cilense, Mário; da Rosa, João Aristeu

    2017-12-01

    Trypanosoma cruzi, the etiological agent of Chagas disease, is transmitted by triatomines that have been described in a large number of studies. Most of those studies are related to external morphology and taxonomy, but some biochemical, genetic and physiological studies have also been published. There are a few publications in the literature about the internal organs of Triatominae, for instance the spermathecae, which are responsible for storing and maintaining the viability of the spermatozoids until the fertilization of the oocytes. This work aims to study the spermathecae of twelve species of triatomines obtained from the Triatominae Insectarium of the Faculty of Pharmaceutical Sciences, UNESP, Araraquara, using optical microscopy and scanning electron microscopy. The spermathecae of the twelve species studied showed three morphological patterns: a) P. herreri sn, P. lignarius, P. megistus, Triatoma brasiliensis, T. juazeirensis, T. sherlocki and T. tibiamaculata have spermathecae with a thin initial portion and an oval-shaped final portion; b) R. montenegrensis, R. nasutus, R. neglectus, R. pictipes and R. prolixus have tubular and winding spermathecae; c) T. infestans has oval spermathecae. In addition to the three morphological patterns, it was noted that each of the twelve species has particular features that differentiate them. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Definition of a Twelve-Point Polygonal SAA Boundary for the GLAST Mission

    International Nuclear Information System (INIS)

    Djomehri, Sabra I.; UC, Santa Cruz; SLAC

    2007-01-01

    The Gamma-Ray Large Area Space Telescope (GLAST), set to launch in early 2008, detects gamma rays within a huge energy range of 100 MeV - 300 GeV. Background cosmic radiation interferes with such detection resulting in confusion over distinguishing cosmic from gamma rays encountered. This quandary is resolved by encasing GLAST's Large Area Telescope (LAT) with an Anti-Coincidence Detector (ACD), a device which identifies and vetoes charged particles. The ACD accomplishes this through plastic scintillator tiles; when cosmic rays strike, photons produced induce currents in Photomultiplier Tubes (PMTs) attached to these tiles. However, as GLAST orbits Earth at altitudes ∼550km and latitudes between -26 degree and 26 degree, it will confront the South Atlantic Anomaly (SAA), a region of high particle flux caused by trapped radiation in the geomagnetic field. Since the SAA flux would degrade the sensitivity of the ACD's PMTs over time, a determined boundary enclosing this region need be attained, signaling when to lower the voltage on the PMTs as a protective measure. The operational constraints on such a boundary require a convex SAA polygon with twelve edges, whose area is minimal ensuring GLAST has maximum observation time. The AP8 and PSB97 models describing the behavior of trapped radiation were used in analyzing the SAA and defining a convex SAA boundary of twelve sides. The smallest possible boundary was found to cover 14.58% of GLAST's observation time. Further analysis of defining a boundary safety margin to account for inaccuracies in the models reveals if the total SAA hull area is increased by ∼20%, the loss of total observational area is < 5%. These twelve coordinates defining the SAA flux region are ready for implementation by the GLAST satellite

  2. New Eyes on the Universe Twelve Cosmic Mysteries and the Tools We Need to Solve Them

    CERN Document Server

    Webb, Stephen

    2012-01-01

    "New Eyes on the Universe -- Twelve Cosmic Mysteries and the Tools We Need to Solve Them" gives an up-to-date broad overview of some of the key issues in modern astronomy and cosmology. It describes the vast amount of observational data that the new generation of observatories and telescopes are currently producing, and how that data might solve some of the outstanding puzzles inherent in our emerging world view. Included are questions such as: What is causing the Universe to blow itself apart? What could be powering the luminous gamma-ray bursters? Where is all the matter in the Uni

  3. A novel double quad-inverter configuration for multilevel twelve-phase open-winding converter

    DEFF Research Database (Denmark)

    Padmanaban, Sanjeevi Kumar; Blaabjerg, Frede; Wheeler, Patrick William

    2016-01-01

    This paper describes a novel proposal of double quad-inverter configuration for multilevel twelve-phase open-winding ac converter. Modular power units are developed from reconfigured eight classical three-phase voltage source inverters (VSIs). Each VSI has one additional bi-directional switching...... numerical simulation software's (Matlab/PLECS) developments. Further, the results confirm the good agreement to the developed theoretical background. Proposed converter suits the need of low-voltage/high-current applications such as ac tractions and `More-Electric Aircraft' propulsion systems....

  4. Work environment perceptions following relocation to open-plan offices: A twelve-month longitudinal study.

    Science.gov (United States)

    Bergström, Jessica; Miller, Michael; Horneij, Eva

    2015-01-01

    A workplace's design can have various positive or negative effects on the employees and since the 1970s the advantages and disadvantages of open-plan offices have been discussed. The aim of this study was to investigate perceived health, work environment and self-estimated productivity one month before and at three, six and twelve months after relocation from individual offices to an open-plan office environment. Employees from three departments within the same company group and who worked with relatively similar tasks and who were planned to be relocated from private offices to open-plan offices were invited to participate. Questionnaires comprising items from The Salutogenic Health Indicator Scale, The Work Experience Measurement Scale, the questionnaire by Brennan et al. about perceived performance and one question from the Work Ability Index were sent to participants one month before relocation (baseline) to open-plan offices and then at three, six and twelve months after relocation. At baseline, 82 questionnaires were sent out. The response rate was 85%. At the follow-ups 77-79 questionnaires were sent out and the response-rate was 70%-81%. At follow-ups, perceived health, job satisfaction and performance had generally deteriorated. The results of the study indicate that employees' perception of health, work environment and performance decreased during a 12 month period following relocation from individual offices to open-plan offices.

  5. Twelve fundamental life histories evolving through allocation-dependent fecundity and survival.

    Science.gov (United States)

    Johansson, Jacob; Brännström, Åke; Metz, Johan A J; Dieckmann, Ulf

    2018-03-01

    An organism's life history is closely interlinked with its allocation of energy between growth and reproduction at different life stages. Theoretical models have established that diminishing returns from reproductive investment promote strategies with simultaneous investment into growth and reproduction (indeterminate growth) over strategies with distinct phases of growth and reproduction (determinate growth). We extend this traditional, binary classification by showing that allocation-dependent fecundity and mortality rates allow for a large diversity of optimal allocation schedules. By analyzing a model of organisms that allocate energy between growth and reproduction, we find twelve types of optimal allocation schedules, differing qualitatively in how reproductive allocation increases with body mass. These twelve optimal allocation schedules include types with different combinations of continuous and discontinuous increase in reproduction allocation, in which phases of continuous increase can be decelerating or accelerating. We furthermore investigate how this variation influences growth curves and the expected maximum life span and body size. Our study thus reveals new links between eco-physiological constraints and life-history evolution and underscores how allocation-dependent fitness components may underlie biological diversity.

  6. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates.

    Science.gov (United States)

    Davie, Jeremiah J; Earl, Josh; de Vries, Stefan P W; Ahmed, Azad; Hu, Fen Z; Bootsma, Hester J; Stol, Kim; Hermans, Peter W M; Wadowsky, Robert M; Ehrlich, Garth D; Hays, John P; Campagnari, Anthony A

    2011-01-26

    M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH), which posits that the species genome possesses a far greater number of genes than any single isolate. Multiple and pair-wise whole genome alignments highlight limited chromosomal re-arrangement. M. catarrhalis gene content and chromosomal organization data, although supportive of the DGH, show modest overall genic diversity. These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens.

  7. Comparative assay of fluorescent antibody test results among twelve European National Reference Laboratories using various anti-rabies conjugates

    DEFF Research Database (Denmark)

    Robardet, E.; Andrieu, S.; Rasmussen, Thomas Bruun

    2013-01-01

    Twelve National Reference Laboratories (NRLs) for rabies have undertaken a comparative assay to assess the comparison of fluorescent antibody test (FAT) results using five coded commercial anti-rabies conjugates (Biorad, Bioveta, Fujirebio, Millipore, and SIFIN conjugates). Homogenized positive...

  8. Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soap.

    Science.gov (United States)

    Kobayashi, Tomoko; Ito, Tomonobu; Kawakami, Hiroshi; Fuzishiro, Kanzan; Hirano, Hirofumi; Okubo, Yukari; Tsuboi, Ryoji

    2015-08-01

    Glupearl 19S, an acid-hydrolyzed wheat protein (HWP), is used widely in Japan as a moisturizing ingredient in facial soaps. Since 2010, there has been an increasing number of reports of contact urticaria and wheat allergy resulting from the use of products containing this substance. Sixty-one patients who had used HWP-containing facial soap visited our hospital. Thirty-five of these experienced urticaria or anaphylaxis after consuming wheat-containing food. Eighteen of the 35 patients tested positive to 0.01% Glupearl 19S solution. Wheat-specific IgE and serum gluten-specific IgE were higher in the patients with HWP allergy than in non-HWP allergy patients. Among the patients who tested positive to Glupearl 19S on the skin prick test, nine experienced HWP-wheat-dependent exercise-induced anaphylaxis, and four experienced food-dependent anaphylaxis. Moreover, four of these patients not only experienced food-dependent anaphylaxis but also a worsening of the symptoms during exercise. The clinical symptomology was so variable that the patients were classified into six groups. We found that patients with HWP allergy tended to manifest symptoms of both HWP-wheat-dependent exercise-induced anaphylaxis and contact urticaria. The etiology of hydrolyzed wheat protein allergy is unknown. Patients with a history of these symptoms need to be informed about the risk of consuming wheat-containing foods and the importance of excluding such items from their diet. © 2015 The International Society of Dermatology.

  9. The twelve-flavor β-function and dilaton tests of the sextet scalar

    Directory of Open Access Journals (Sweden)

    Fodor Zoltan

    2018-01-01

    Full Text Available We discuss near-conformal gauge theories beyond the standard model (BSM where interesting results on the twelve-flavor β-function of massless fermions in the fundamental representation of the SU(3 color gauge group and dilaton tests of the light scalar with two massless fermions in the two-index symmetric tensor (sextet representation can be viewed as parts of the same BSM paradigm under investigation. The clear trend in the decreasing size of β-functions at fixed renormalized gauge coupling is interpreted as a first indicator how the conformal window (CW is approached in correlation with emergent near-conformal light scalars. BSM model building close to the CW will be influenced by differing expectations on the properties of the emergent light 0++ scalar either as a σ-particle of chiral symmetry breaking (ΧS B, or as a dilaton of scale symmetry breaking. The twelve-flavor β-function emerges as closest to the CW, perhaps near-conformal, or perhaps with an infrared fixed point (IRFP at some unexplored strong coupling inside the CW. It is premature to speculate on dilaton properties of the twelveflavor model since the near-conformal realization remains an open question. However, it is interesting and important to investigate dilaton tests of the light sextet scalar whose β-function is closest to the CW in the symmetry breaking phase and emerges as the leading candidate for dilaton tests of the light scalar. We report results from high precision analysis of the twelve-flavor β-function [1] refuting its published IRFP [2, 3]. We present our objections to recent claims [4, 5] for non-universal behavior of staggered fermions used in our analysis. We also report our first analysis of dilaton tests of the light 0++ scalar in the sextet model and comment on related post-conference developments. The dilaton test is the main thrust of this conference contribution including presentation #405 on the nf = 12 β-function and presentation #260 on dilaton

  10. Twelve recommendations for integrating existing systematic reviews into new reviews: EPC guidance.

    Science.gov (United States)

    Robinson, Karen A; Chou, Roger; Berkman, Nancy D; Newberry, Sydne J; Fu, Rongwei; Hartling, Lisa; Dryden, Donna; Butler, Mary; Foisy, Michelle; Anderson, Johanna; Motu'apuaka, Makalapua; Relevo, Rose; Guise, Jeanne-Marie; Chang, Stephanie

    2016-02-01

    As time and cost constraints in the conduct of systematic reviews increase, the need to consider the use of existing systematic reviews also increases. We developed guidance on the integration of systematic reviews into new reviews. A workgroup of methodologists from Evidence-based Practice Centers developed consensus-based recommendations. Discussions were informed by a literature scan and by interviews with organizations that conduct systematic reviews. Twelve recommendations were developed addressing selecting reviews, assessing risk of bias, qualitative and quantitative synthesis, and summarizing and assessing body of evidence. We provide preliminary guidance for an efficient and unbiased approach to integrating existing systematic reviews with primary studies in a new review. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Twelve Tips for teaching medical professionalism at all levels of medical education.

    Science.gov (United States)

    Al-Eraky, Mohamed Mostafa

    2015-01-01

    Review of studies published in medical education journals over the last decade reveals that teaching medical professionalism is essential, yet challenging. According to a recent Best Evidence in Medical Education (BEME) guide, there is no consensus on a theoretical or practical model to integrate the teaching of professionalism into medical education. The aim of this article is to outline a practical manual for teaching professionalism at all levels of medical education. Drawing from research literature and author's experience, Twelve Tips are listed and organised in four clusters with relevance to (1) the context, (2) the teachers, (3) the curriculum, and (4) the networking. With a better understanding of the guiding educational principles for teaching medical professionalism, medical educators will be able to teach one of the most challenging constructs in medical education.

  12. Twelve tips for developing and delivering a massive open online course in medical education.

    Science.gov (United States)

    Pickering, James D; Henningsohn, Lars; DeRuiter, Marco C; de Jong, Peter G M; Reinders, Marlies E J

    2017-07-01

    Massive open online courses (MOOCs) are a novel mode of online learning. They are typically based on higher education courses and can attract a high number of learners, often in the thousands. They are distinct from on-campus education and deliver the learning objectives through a series of short videos, recommended readings and discussion fora, alongside automated assessments. Within medical education the role of MOOCs remains unclear, with recent proposals including continuing professional development, interprofessional education or integration into campus-based blended learning curricula. In this twelve tips article, we aim to provide a framework for readers to use when developing, delivering and evaluating a MOOC within medical education based on the literature and our own experience. Practical advice is provided on how to design the appropriate curriculum, engage with learners on the platform, select suitable assessments, and comprehensively evaluate the impact of your course.

  13. Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.

    Science.gov (United States)

    Yang, Ya-Nan; Huang, Xiao-Ying; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Pei-Cheng

    2014-09-17

    Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-O-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly known as Arctii Fructus. Their structures were elucidated using spectroscopy (1D and 2D NMR, MS, IR, ORD, and UV) and on the basis of chemical evidence. The absolute configurations of compounds 1-12 were confirmed using rotating frame nuclear overhauser effect spectroscopy (ROESY), the circular dichroic (CD) exciton chirality method, and Rh2(OCOCF3)4-induced CD spectrum analysis. All of the isolated compounds were tested for hepatoprotective effects against D-galactosamine-induced cytotoxicity in HL-7702 hepatic cells. Compounds 1, 2, 7-12, and 17 showed significantly stronger hepatoprotective activity than the positive control bicyclol at a concentration of 1 × 10(-5) M.

  14. [Longitudinal genetic effects on mandibular position of female twins from six to twelve years old].

    Science.gov (United States)

    Zhu, Chang-feng; Peng, Jing

    2013-06-01

    To find the longitudinal genetic effects on mandibular position in mixed dentition. The sample used in this study consisted of lateral cephalograms of eighty-nine pairs of female twins in Beijing. With a mixed longitudinal method, the effective twins were 183 pairs(monozygous 110 pairs and dizygous 73 ones). The genetic and environmental effects on mandibular position were analyzed by statistical methods in female twins from six to twelve years old. Statistical comparisons revealed significant (Pchin is the most subjective to environment change, then the mandibular angle, and the condyle is the least. Using N and S as references, the environmental influence on heights showed different order from the most to least changeable: The mandibular angle, the condyle and the chin. In later stage of our observation, the mandibular morphology and growth type might be family inherited. For environmental influences plays important roles on mandibular position, these findings can be used in orthodontic treatment planning.

  15. Exploring Content Schemata Influence on L2 Reading: The Hunted Fox and Twelve and Not Stupid

    Directory of Open Access Journals (Sweden)

    Amizura Hanadi Mohd Radzi

    2014-10-01

    Full Text Available This paper will discuss the aspects of content schemata in second language reading among diploma level students who were taking a reading course in Universiti Teknologi MARA Perlis. In this qualitative case study, the researcher had selected two short stories that are categorized as content-familiar texts, i.e. The Hunted Fox and Twelve and Not Stupid. Six participants were asked to write a 150-word entry response on the short story and a grading criteria was used to assess the participants’ level of comprehension. An in-depth interview was also conducted on each participant. The entry responses and the interview patterns were analyzed to determine whether content schemata had contributed to the learners’ understanding of the text. This study discovered that content schemata had contributed to the learners’ understanding of the text because the learners’ comprehension was facilitated by their background knowledge on the content-familiar texts.

  16. Development of twelve microsatellite loci in the red tree corals Primnoa resedaeformis and Primnoa pacifica

    Science.gov (United States)

    Morrison, Cheryl L.; Springmann, Marcus J.; Shroades, Kelsey; Stone, Robert P.

    2015-01-01

    A suite of tetra-, penta-, and hexa-nucleotide microsatellite loci were developed from Roche 454 pyrosequencing data for the cold-water octocorals Primnoa resedaeformis and P. pacifica. Twelve of 98 primer sets tested consistently amplified in 30 P. resedaeformis samples from Baltimore Canyon (western North Atlantic Ocean) and in 24 P. pacifica samples (Shutter Ridge, eastern Gulf of Alaska). The loci displayed moderate levels of allelic diversity (average 7.5 alleles/locus) and heterozygosity (average 47 %). Levels of genetic diversity were sufficient to produce unique multi-locus genotypes and to distinguish species. These common species are long-lived (hundreds of years) and provide essential fish habitat (P. pacifica), yet populations are provided little protection from human activities. These loci will be used to determine regional patterns of population connectivity to inform effective marine spatial planning and ecosystem-based fisheries management.

  17. Twelve tips for teaching child development and disability to medical students.

    Science.gov (United States)

    McDonald, Jenny

    2018-02-01

    Child development is a marker of well-being in childhood and recognition of developmental delay allows timely investigation and intervention for children with developmental disabilities. Despite this, child development and disabilities are not given emphasis in the medical curriculum. This under representation of teaching combined with the stigma associated with disabilities contributes to the sub-optimal health care of people with disabilities. As well as, addressing the stigma of disability a medical undergraduate curriculum should include: the key concepts of child development; the clinical presentation of the most common developmental disabilities; developmental history taking and the infant neurodevelopmental examination. The following twelve tips provide practical advice about how to teach this knowledge and these skills during medical training.

  18. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

    Directory of Open Access Journals (Sweden)

    Hermans Peter WM

    2011-01-01

    Full Text Available Abstract Background M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM and exacerbations of chronic obstructive pulmonary disease (COPD. With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed. Results The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive analyses aimed at characterizing the supragenome and understanding the metabolic and pathogenic potential of this species. A total of 2383 gene clusters were identified, of which 1755 are core with the remaining 628 clusters unevenly distributed among the twelve isolates. These findings are consistent with the distributed genome hypothesis (DGH, which posits that the species genome possesses a far greater number of genes than any single isolate. Multiple and pair-wise whole genome alignments highlight limited chromosomal re-arrangement. Conclusions M. catarrhalis gene content and chromosomal organization data, although supportive of the DGH, show modest overall genic diversity. These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens.

  19. In vitro antibacterial and antifungal activities of twelve sponges collected from the Anambas Islands, Indonesia

    Directory of Open Access Journals (Sweden)

    Masteria Yunovilsa Putra

    2016-09-01

    Full Text Available Objective: To evaluate antimicrobial activities in methanolic extracts of twelve sponges collected from the Anambas Islands, Indonesia. Methods: The antibacterial activity of methanolic extracts was tested against two Grampositive bacteria, viz. Bacillus subtilis (ATCC 6633 and Staphylococcus aureus (ATCC 25923, and two Gram-negative bacteria, viz. Eschericia coli (ATCC 25922 and Vibrio anguillarum (ATCC 19264 using the disk diffusion assay. The antifungal activity was similarly tested against Candida albicans (ATCC 10231 and Aspergillus niger (ATCC 16404. The minimum inhibitory concentrations of promising sponges extracts were determined by the microdilution technique. Results: All the sponge species in this study showed antimicrobial activities against at least one of the test strains. Antibacterial activities were observed in 66.7% of the sponges extracts, while 30.0% of the extracts exhibited antifungal activities. Among them, the extracts of the sponges Stylissa massa and Axinyssa sp. were the most active against four tested bacteria and the yeast Candida albicans. The sponge Theonella swinhoei and two species of Xestospongia also displayed significant activities against two fungal pathogens Candida albicans and Aspergillus niger. Conclusions: Antimicrobial activities were demonstrated in extracts from various marine sponges collected from the Anambas Islands, Indonesia. The most promising sponges among them were Stylissa massa and Axinyssa sp. This is the first report of antimicrobial activity in extracts of marine sponges from the Indonesian Anambas Islands.

  20. Twelve Monkeys, the Kassandra dilemma and innovation diffusion: transdisciplinary lessons for animal and environmental activism

    Directory of Open Access Journals (Sweden)

    Sarah Rutherford Smith

    2014-07-01

    Full Text Available Animal activists and environmental activists believe that the world and its inhabitants face devastating consequences in the future if behaviour towards and the treatment of animals and the environment do not change. However, despite their predictions many people are not swayed to change their behaviour. This article suggests that these activists experience what is known as Kassandra’s dilemma; the conundrum of knowing what the future holds but being unable to prevent events from happening. Drawing on the film, Twelve Monkeys and Greek mythology this article explores this mythological dilemma and explains how this dilemma is a lived experience for activists. The article suggests that activists can resolve Kassandra’s dilemma by taking a transdisciplinary approach towards animal and environmental activism. Thus, in order to escape Kassandra’s dilemma the article suggests that animal and environmental activists require transdisciplinary knowledge; knowledge of the actual and potential harm done to animals and the environment and how this can be prevented as well as knowledge on how to successfully convey this knowledge to others. The article highlights innovation diffusion theory as an example of the type of transdisciplinary knowledge that could assist in escaping from Kassandra’s dilemma and in order to better advocate on behalf of animals and the environment.

  1. Risk of stress urinary incontinence twelve years after the first pregnancy and delivery.

    Science.gov (United States)

    Viktrup, Lars; Rortveit, Guri; Lose, Gunnar

    2006-08-01

    To estimate the impact of onset of stress urinary incontinence in first pregnancy or postpartum period, for the risk of symptoms 12 years after the first delivery. In a longitudinal cohort study, 241 women answered validated questions about stress urinary incontinence after first delivery and 12 years later. Twelve years after first delivery the prevalence of stress urinary incontinence was 42% (102 of 241). The 12-year incidence was 30% (44 of 146). The prevalence of stress urinary incontinence 12 years after first pregnancy and delivery was significantly higher (Ppregnancy (56%, 37 of 66) and in women with onset shortly after delivery (78%, 14 of 18) compared with those without initial symptoms (30%, 44 of 146). In 70 women who had onset of symptoms during first pregnancy or shortly after the delivery but remission 3 months postpartum, a total of 40 (57%) had stress urinary incontinence 12 years later. In 11 women with onset of symptoms during the first pregnancy or shortly after delivery but no remission 3 months postpartum, a total of 10 (91%) had stress urinary incontinence 12 years later. Cesarean during first delivery was significantly associated with a lower risk of incontinence. Other obstetric factors were not significantly associated with the risk of incontinence 12 years later. Patients who were overweight before their first pregnancy were at increased risk. Onset of stress urinary incontinence during first pregnancy or puerperal period carries an increased risk of long-lasting symptoms.

  2. High-energy, twelve-channel laser facility (DEFIN) for spherical irradiation of thermonuclear targets

    International Nuclear Information System (INIS)

    Basov, N.G.; Danilov, A.E.; Krokhin, O.N.; Kruglov, B.V.; Mikhailov, Yu.A.; Sklizkov, G.V.; Fedotov, S.I.; Fedorov, A.N.

    This paper describes a high-energy, twelve-channel laser facility (DELFIN) intended for high-temperature heating of thermonuclear targets with spherical symmetry. The facility includes a neodymium-glass laser with the ultimate radiation energy of 10 kJ, a pulse length of approximately 10 -10 to 10 -9 s, beam divergence of 5 x 10 -4 radians, a vacuum chamber in which laser radiation interacts with the plasma, and a system of diagnostic instrumentation for the observation of laser beam and plasma parameters. Described are the optical scheme and construction details of the laser facility. Presented is an analysis of focusing schemes for target irradiation and described is the focusing scheme of the DELFIN facility, which is capable of attaining a high degree of spherical symmetry in irradiating targets with maximum beam intensity at the target surface of approximately 10 15 W/cm 2 . This paper examines the most important problems connected with the physical investigations of thermonuclear laser plasma and the basic diagnostic problems involved in their solution

  3. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VIII. CATALOG OF TRANSIT TIMING MEASUREMENTS OF THE FIRST TWELVE QUARTERS

    Energy Technology Data Exchange (ETDEWEB)

    Mazeh, Tsevi; Nachmani, Gil; Holczer, Tomer; Sokol, Gil [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Fabrycky, Daniel C. [Department of Astronomy and Astrophysics, University of Chicago, 5640 Ellis Ave., Chicago, IL 60637 (United States); Ford, Eric B.; Ragozzine, Darin [Astronomy Department, University of Florida, Gainesville, FL 32111 (United States); Sanchis-Ojeda, Roberto [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Rowe, Jason F.; Lissauer, Jack J. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Zucker, Shay [Department of Geophysical, Atmospheric and Planetary Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences Tel Aviv University, 69978 Tel Aviv (Israel); Agol, Eric [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Carter, Joshua A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Quintana, Elisa V. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Steffen, Jason H. [Fermilab Center for Particle Astrophysics, P.O. Box 500, MS 127, Batavia, IL 60510 (United States); Welsh, William [Astronomy Department, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 (United States)

    2013-10-01

    Following the works of Ford et al. and Steffen et al. we derived the transit timing of 1960 Kepler objects of interest (KOIs) using the pre-search data conditioning light curves of the first twelve quarters of the Kepler data. For 721 KOIs with large enough signal-to-noise ratios, we obtained also the duration and depth of each transit. The results are presented as a catalog for the community to use. We derived a few statistics of our results that could be used to indicate significant variations. Including systems found by previous works, we have found 130 KOIs that showed highly significant times of transit variations (TTVs) and 13 that had short-period TTV modulations with small amplitudes. We consider two effects that could cause apparent periodic TTV—the finite sampling of the observations and the interference with the stellar activity, stellar spots in particular. We briefly discuss some statistical aspects of our detected TTVs. We show that the TTV period is correlated with the orbital period of the planet and with the TTV amplitude.

  4. [Courses in basic research methodology a valuable asset for clinicians. Twelve years' experiences in southern Sweden].

    Science.gov (United States)

    Håkansson, Anders; Lindberg, Eva Pettersson; Henriksson, Karin

    2002-03-07

    At the Department of Community Medicine at Lund University we have given courses in basic research methodology since 1989. The course has yielded 20 points of university credit, the equivalent of one full-time semester of studies, and it has been run part-time, covering one and a half years. Our aim has been to provide a large number of physicians with basic training in research methods, and to stimulate the engagement of new scientific students from the whole Southern Health Care Region. During the first ten years, 138 general practitioners (20% of the GPs of the region) and 202 specialists completed our courses. Up till now, 19 GPs (14%) and 19 specialists (9%) have begun PhD studies. During the last two years, another 100 physicians from southern Sweden have attended our courses, as well as GPs from Zealand in Denmark. We have been developing our course in basic research methods during a twelve-year period, and it is now well established in our health care region. We feel that we have succeeded in reaching the two goals we had set up: to give a large number of physicians a fundamental knowledge of research methods and to recruit and increase the number of PhD students. We believe that medical research and development must flourish also outside the traditional university settings.

  5. Twelve Years of the HST Advanced Camera for Surveys : Calibration Update

    Science.gov (United States)

    Grogin, Norman A.

    2014-06-01

    The Advanced Camera for Surveys (ACS) has been a workhorse HST imager for over twelve years, subsequent to its Servicing Mission 3B installation. The once defunct ACS Wide Field Channel (WFC) has now been operating longer since its Servicing Mission 4 repair than it had originally operated prior to its 2007 failure. Despite the accumulating radiation damage to the WFC CCDs during their long stay in low Earth orbit, ACS continues to be heavily exploited by the HST community as both a prime and a parallel detector. Conspicuous examples include the recently completed HST Multi-cycle Treasury programs, and the ongoing HST Frontier Fields (HFF) program.We review recent developments in ACS calibration that enable the continued high performance of this instrument, with particular attention the to the Wide Field Channel. Highlights include: 1) the refinement of the WFC geometric distortion solution and its time dependency; 2) the efficacy of both pixel-based and catalog-based corrections for the worsening WFC charge-transfer efficiency (CTE); 3) the extension of pixel-based CTE correction to the WFC 2K subarray mode; and 4) a novel "self-calibration" technique appropriate for large-number stacks of deep WFC exposures (such as the HFF targets) that provides superior reductions compared to the standard CALACS reduction pipeline.

  6. Transitioning HIV-Positive Adolescents to Adult Care: Lessons Learned From Twelve Adolescent Medicine Clinics.

    Science.gov (United States)

    Tanner, Amanda E; Philbin, Morgan M; DuVal, Anna; Ellen, Jonathan; Kapogiannis, Bill; Fortenberry, J Dennis

    2016-01-01

    To maximize positive health outcomes for youth with HIV as they transition from youth to adult care, clinical staff need strategies and protocols to help youth maintain clinic engagement and medication adherence. Accordingly, this paper describe transition processes across twelve clinics within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) to provide lessons learned and inform the development of transition protocols to improve health outcomes as youth shift from adolescent to adult HIV care. During a large multi-method Care Initiative program evaluation, three annual visits were completed at each site from 2010-2012 and conducted 174 semi-structured interviews with clinical and program staff (baseline n=64, year 1 n=56, year 2=54). The results underscore the value of adhering to recent American Academy of Pediatrics (AAP) transition recommendations, including: developing formal transition protocols, preparing youth for transition, facilitating youth's connection to the adult clinic, and identifying necessary strategies for transition evaluation. Transitioning youth with HIV involves targeting individual-, provider-, and system-level factors. Acknowledging and addressing key barriers is essential for developing streamlined, comprehensive, and context-specific transition protocols. Adolescent and adult clinic involvement in transition is essential to reduce service fragmentation, provide coordinated and continuous care, and support individual and community level health. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Correlation between clinical severity and type and degree of pectus excavatum in twelve brachycephalic dogs.

    Science.gov (United States)

    Hassan, Elham A; Hassan, Marwa H; Torad, Faisal A

    2018-05-18

    The aim of the study was to correlate the clinical severity of pectus excavatum with its type and degree based on objective radiographic evaluation. Twelve brachycephalic dogs were included. Grading of the clinical severity was done based on a 6-point grading score. Thoracic radiographs were used to calculate the frontosagittal and vertebral indices at the tenth thoracic vertebra and the vertebra overlying the excavatum. Correlation between the clinical severity score and frontosagittal and vertebral indices was evaluated using Pearson's correlation coefficient. Typical pectus excavatum was recorded in the caudal sternum in seven dogs, with a mean clinical severity score of 1.7 ± 1.4, whereas in five dogs, atypical mid-sternal deviation was recorded with a mean clinical severity score of 3.8 ± 0.7. A strong correlation (r=0.7) was recorded between the clinical severity score and vertebral index in the atypical form, whereas a weak correlation (r=0.02) was recorded in the typical form (Pcorrelated (r=0.3) in the typical form of pectus excavatum, whereas it was strongly correlated (r=0.9) in the atypical form. Pectus excavatum in dogs is associated with compressive cardiopulmonary dysfunction, which depends mainly on the site/type of deviation rather than the degree of deviation.

  8. Aliphatic hydrocarbon and polycyclic aromatic hydrocarbon geochemistry of twelve major rivers in the Northwest Territories

    International Nuclear Information System (INIS)

    Backus, S.; Swyripa, M.; Peddle, J.; Jeffries, D.S.

    1995-01-01

    Suspended sediment and water samples collected from twelve major rivers in the Northwest Territories were analyzed for aliphatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs) to assess the sources and transport of hydrocarbons entering the Arctic Ocean. Three stations on the Mackenzie River and one station near the mouth of eleven other northern rivers were selected for sampling. Samples were collected on the Mackenzie River on four occasions to characterize spring, summer and fall flow conditions and once on the remaining eleven rivers during high flow conditions. The Mackenzie River is distinctively different then the other eleven rivers. Naturally occurring hydrocarbons predominate in the river. These hydrocarbons include biogenic alkanes, diagenic PAHs, petrogenic alkanes, and PAHs from oil seeps and/or bitumens. Anthropogenic inputs of PAHs are low as indicated by low concentrations of combustion PAHs. Alkyl PAH distributions indicate that a significant component of the lower molecular weight PAH fraction is petrogenic. The majority of the high molecular weight PAHs, together with the petrogenic PAHs have a principal source in the Mackenzie River

  9. Whole-Proteome Analysis of Twelve Species of Alphaproteobacteria Links Four Pathogens

    Directory of Open Access Journals (Sweden)

    Yunyun Zhou

    2013-11-01

    Full Text Available Thousands of whole-genome and whole-proteome sequences have been made available through advances in sequencing technology, and sequences of millions more organisms will become available in the coming years. This wealth of genetic information will provide numerous opportunities to enhance our understanding of these organisms including a greater understanding of relationships among species. Researchers have used 16S rRNA and other gene sequences to study the evolutionary origins of bacteria, but these strategies do not provide insight into the sharing of genes among bacteria via horizontal transfer. In this work we use an open source software program called pClust to cluster proteins from the complete proteomes of twelve species of Alphaproteobacteria and generate a dendrogram from the resulting orthologous protein clusters. We compare the results with dendrograms constructed using the 16S rRNA gene and multiple sequence alignment of seven housekeeping genes. Analysis of the whole proteomes of these pathogens grouped Rickettsia typhi with three other animal pathogens whereas conventional sequence analysis failed to group these pathogens together. We conclude that whole-proteome analysis can give insight into relationships among species beyond their phylogeny, perhaps reflecting the effects of horizontal gene transfer and potentially providing insight into the functions of shared genes by means of shared phenotypes.

  10. Twelve-Year Trends of PM10 and Visibility in the Hefei Metropolitan Area of China

    Directory of Open Access Journals (Sweden)

    Lin Huang

    2016-01-01

    Full Text Available China has been experiencing severe air pollution and previous studies have mostly focused on megacities and a few hot spot regions. Hefei, the provincial capital city of Anhui province, has a population of near 5 million in its metropolitan area, but its air quality has not been reported in literature. In this study, daily PM10 and visibility data in 2001–2012 were analyzed to investigate the air quality status as well as the twelve-year pollution trends in Hefei. The results reveal that Hefei has been suffering high PM10 pollution and low visibility during the study period. The annual average PM10 concentrations are 2~3 times of the Chinese Ambient Air Quality Standard. PM10 shows fluctuating variation in 2001–2007 and has a slightly decreasing trend after 2008. The annual average visibility range is generally lower than 7 km and shows a worsening trend from 2001 to 2006 followed by an improving trend from 2007 to 2012. Wind speed, precipitation, and relative humidity have negative effects on PM10 concentrations in Hefei, while temperature could positively or negatively affect PM10. The results provide a general understanding of the status and long-term trends of PM10 pollution and visibility in a typical second-tier city in China.

  11. Estimation of admixture of twelve quark bag state in sup 4 He nucleus

    CERN Document Server

    Mosallem, A M

    2002-01-01

    The p sup 4 He elastic scattering at the energy range from 0.695 to 393 GeV is analyzed in the framework of the Glauber theory. The Glauber amplitudes were evaluated using isospin-averaged nucleon-nucleon amplitudes and the sup 4 He wave function as a superposition of the Gaussian functions. The values of the calculated differential cross sections usually exceed the experimental ones. In order to overcome the discrepancy, it is assumed following to the paper by L. G. Dakno and N. N. Nikolaev that the ground state wave function of sup 4 He has an admixture of a twelve quark bag. Neglecting all transition amplitudes, the p - 12q bag scattering amplitude was chosen in a simple Gaussian form.The inclusion of the 12q bag leads to decreasing the p sup 4 He differential cross section and to a shift of the dip position to a large values of t what is needed for a successful description of the experimental data. While fitting the data it is found that the weight of the 12q bag state in the ground state of the sup 4 He ...

  12. What about Gender in Climate Change? Twelve Feminist Lessons from Development

    Directory of Open Access Journals (Sweden)

    Anne Jerneck

    2018-02-01

    Full Text Available Adaptation and mitigation are two key responses to climate change. In the global South they prompt many questions: what is the direction and degree of change needed? How can new climate change policies be aligned with existing development initiatives? How are core social relations such as gender understood and prioritized in relation to technical and other solutions? In search of synergies between adaptation, development and mitigation, this article asks a pertinent question for sub-Saharan small-scale agriculture in particular: what can adaptation and mitigation learn from development debates on social goal setting, institutional change and gender equality? From the perspective of sustainability science and feminist literature, three main findings emerge. First, as regards social goal setting, adaptation and mitigation should, like development, support the escape out of poverty, ill-health and food-insecurity. Second, as regards institutions, adaptation and mitigation should address how gender regulates access to, use of and control over resources in terms of labor, land and strategic decision-making power. Third, as regards gender equality, adaptation and mitigation should learn from how development in theory and practice has addressed gender, women, nature and the environment. At its core, the analysis contributes twelve salient themes that can significantly inform adaptation and mitigation in research, policy and practice, thus serving as inspiration for a critical debate on much needed synergetic trajectories.

  13. Ecological conversion efficiency and its influencers in twelve species of fish in the Yellow Sea Ecosystem

    Science.gov (United States)

    Tang, Qisheng; Guo, Xuewu; Sun, Yao; Zhang, Bo

    2007-09-01

    The ecological conversion efficiencies in twelve species of fish in the Yellow Sea Ecosystem, i.e., anchovy ( Engraulis japonicus), rednose anchovy ( Thrissa kammalensis), chub mackerel ( Scomber japonicus), halfbeak ( Hyporhamphus sajori), gizzard shad ( Konosirus punctatus), sand lance ( Ammodytes personatus), red seabream ( Pagrus major), black porgy ( Acanthopagrus schlegeli), black rockfish ( Sebastes schlegeli), finespot goby ( Chaeturichthys stigmatias), tiger puffer ( Takifugu rubripes), and fat greenling ( Hexagrammos otakii), were estimated through experiments conducted either in situ or in a laboratory. The ecological conversion efficiencies were significantly different among these species. As indicated, the food conversion efficiencies and the energy conversion efficiencies varied from 12.9% to 42.1% and from 12.7% to 43.0%, respectively. Water temperature and ration level are the main factors influencing the ecological conversion efficiencies of marine fish. The higher conversion efficiency of a given species in a natural ecosystem is acquired only under the moderate environment conditions. A negative relationship between ecological conversion efficiency and trophic level among ten species was observed. Such a relationship indicates that the ecological efficiency in the upper trophic levels would increase after fishing down marine food web in the Yellow Sea ecosystem.

  14. Peer teaching in medical education: twelve reasons to move from theory to practice.

    Science.gov (United States)

    Ten Cate, Olle; Durning, Steven

    2007-09-01

    To provide an estimation of how often peer teaching is applied in medical education, based on reports in the literature and to summarize reasons that support the use of this form of teaching. We surveyed the 2006 medical education literature and categorised reports of peer teaching according to educational distance between students teaching and students taught, group size, and level of formality of the teaching. Subsequently, we analysed the rationales for applying peer teaching. Most reports were published abstracts in either Medical Education's annual feature 'Really Good Stuff' or the AMEE's annual conference proceedings. We identified twelve distinct reasons to apply peer teaching, including 'alleviating faculty teaching burden', 'providing role models for junior students', 'enhancing intrinsic motivation' and 'preparing physicians for their future role as educators'. Peer teaching appears to be practiced often, but many peer teaching reports do not become full length journal articles. We conclude that specifically 'near-peer teaching' appears beneficial for student teachers and learners as well as for the organisation. The analogy of the 'journeyman', as intermediate between 'apprentice' and 'master', with both learning and teaching tasks, is a valuable but yet under-recognized source of education in the medical education continuum.

  15. Alcoholics Anonymous and twelve-step recovery: a model based on social and cognitive neuroscience.

    Science.gov (United States)

    Galanter, Marc

    2014-01-01

    In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change. Literature review and hypothesis development. Pertinent aspects of the neural impact of drugs of abuse are summarized. After this, research regarding specific brain sites, elucidated primarily by imaging techniques, is reviewed relative to the following: Mirroring and mentalizing are described in relation to experimentally modeled studies on empathy and mutuality, which may parallel the experiences of social interaction and influence on AA members. Integration and retrieval of memories acquired in a setting like AA are described, and are related to studies on storytelling, models of self-schema development, and value formation. A model for ascription to a Higher Power is presented. The phenomena associated with AA reflect greater complexity than the empirical studies on which this article is based, and certainly require further elucidation. Despite this substantial limitation in currently available findings, there is heuristic value in considering the relationship between the brain-based and clinical phenomena described here. There are opportunities for the study of neuroscientific correlates of Twelve-Step-based recovery, and these can potentially enhance our understanding of related clinical phenomena. © American Academy of Addiction Psychiatry.

  16. Weight of preterm newborns during the first twelve weeks of life

    Directory of Open Access Journals (Sweden)

    L.M. Anchieta

    2003-06-01

    Full Text Available A longitudinal and prospective study was carried out at two state-operated maternity hospitals in Belo Horizonte during 1996 in order to assess the weight of preterm appropriate-for-gestational-age newborns during the first twelve weeks of life. Two hundred and sixty appropriate-for-gestational-age preterm infants with birth weight <2500 g were evaluated weekly. The infants were divided into groups based on birth weight at 250-g intervals. Using weight means, somatic growth curves were constructed and adjusted to Count's model. Absolute (g/day and relative (g kg-1 day-1 velocity curves were obtained from a derivative of this model. The growth curve was characterized by weight loss during the 1st week (4-6 days ranging from 5.9 to 13.3% (the greater the percentage, the lower the birth weight, recovery of birth weight within 17 and 21 days, and increasingly higher rates of weight gain after the 3rd week. These rates were proportional to birth weight when expressed as g/day (the lowest and the highest birth weight neonates gained 15.9 and 30.1 g/day, respectively. However, if expressed as g kg-1 day-1, the rates were inversely proportional to birth weight (during the 3rd week, the lowest and the highest weight newborns gained 18.0 and 11.5 g kg-1 day-1, respectively. During the 12th week the rates were similar for all groups (7.5 to 10.2 g kg-1 day-1. The relative velocity accurately reflects weight gain of preterm infants who are appropriate for gestational age and, in the present study, it was inversely proportional to birth weight, with a peak during the 3rd week of life, and a homogeneous behavior during the 12th week for all weight groups.

  17. Twelve Years of Education and Public Outreach with the Fermi Gamma-ray Space Telescope

    Science.gov (United States)

    Cominsky, Lynn R.; McLin, K. M.; Simonnet, A.; Fermi E/PO Team

    2013-04-01

    During the past twelve years, NASA's Fermi Gamma-ray Space Telescope has supported a wide range of Education and Public Outreach (E/PO) activities, targeting K-14 students and the general public. The purpose of the Fermi E/PO program is to increase student and public understanding of the science of the high-energy Universe, through inspiring, engaging and educational activities linked to the mission’s science objectives. The E/PO program has additional more general goals, including increasing the diversity of students in the Science, Technology, Engineering and Mathematics (STEM) pipeline, and increasing public awareness and understanding of Fermi science and technology. Fermi's multi-faceted E/PO program includes elements in each major outcome category: ● Higher Education: Fermi E/PO promotes STEM careers through the use of NASA data including research experiences for students and teachers (Global Telescope Network), education through STEM curriculum development projects (Cosmology curriculum) and through enrichment activities (Large Area Telescope simulator). ● Elementary and Secondary education: Fermi E/PO links the science objectives of the Fermi mission to well-tested, customer-focused and NASA-approved standards-aligned classroom materials (Black Hole Resources, Active Galaxy Education Unit and Pop-up book, TOPS guides, Supernova Education Unit). These materials have been distributed through (Educator Ambassador and on-line) teacher training workshops and through programs involving under-represented students (after-school clubs and Astro 4 Girls). ● Informal education and public outreach: Fermi E/PO engages the public in sharing the experience of exploration and discovery through high-leverage multi-media experiences (Black Holes planetarium and PBS NOVA shows), through popular websites (Gamma-ray Burst Skymap, Epo's Chronicles), social media (Facebook, MySpace), interactive web-based activities (Space Mysteries, Einstein@Home) and activities by

  18. Twelve-year history of late-life depression and subsequent feelings to God.

    Science.gov (United States)

    Braam, Arjan W; Schaap-Jonker, Hanneke; van der Horst, Marleen H L; Steunenberg, Bas; Beekman, Aartjan T F; van Tilburg, Willem; Deeg, Dorly J H

    2014-11-01

    Growing evidence shows several possible relations between religiousness and late-life depression. Emotional aspects of religiousness such as facets of the perceived relationship with God can be crucial in this connection. The aim of the current study was to examine the association between the course of late-life depression and feelings about God and religious coping. Longitudinal survey study; naturalistic; 12-year follow-up. Longitudinal Aging Study Amsterdam; population-based, in three regions in The Netherlands. A subsample of 343 respondents (mean age: 77.2 years), including all respondents with high levels of depressive symptoms at any measurement cycle between 1992 and 2003 (assessed by using the Center for Epidemiologic Studies Depression Scale and the Diagnostic Interview Schedule) and a random sample of nondepressed respondents who completed a postal questionnaire in 2005. Scales on God Image and Religious Coping. Twelve-year depression course trajectories serve as predicting variables and are specified according to recency and seriousness. Persistent and emergent depression are significantly associated with fear of God, feeling wronged by God, and negative religious coping. In terms of negative religious coping, significant associations were observed after adjustment for concurrent depression with a history of repeated minor depression and previous major depression. Late-life depression seems to maintain a pervasive relationship over time with affective aspects of religiousness. Religious feelings may parallel the symptoms of anhedonia or a dysphoric mood and could represent the experience of an existential void. Copyright © 2014 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  19. Interventional effect of multiple LDR on splenocyte apoptosis and immunity on twelve-week diabetic rats

    International Nuclear Information System (INIS)

    Li Yanbo; Wang Zhicheng; Li Pengwu; Guo Wei; Zhao Hongguang; Liu Yang; Gong Shouliang; Guo Caixia

    2009-01-01

    In order to explore the effect of multiple low dose irradiation (LDR) on the apoptosis of splenocytes, immune factors and lymphocyte subgroups in twelve-week diabetes mellitus (DM), the experiment was carried out with control, DM and DM+LDR groups. The irradiation dose every time was 25, 50 and 75 mGy respectively, and the irradiated times were 15. At the eighth weekend after the DM rats were irradiated, the percentages of CD4 + , CD8 + T lymphocytes and TCR α β were detected by flowcytometry (FCM). The content of IL-2 in both serum and supernatant of cultured splenocytes were detected by ELISA. And the apoptotic rate of splenocytes was detected by FCM and TUNEL respectively. The result shows that as compared with that in the control, the body weight (BW) decreases both in the DM and the DM + LDR groups, particularly in the DM group. The blood glucose (BG) level in the DM+LDR groups is higher than that in the control, but lower than that in the DM group. As compared with those in the control, the percentages of TCR α β and CD4 + T cells, the content of IL-2 in serum and supernatant of cultured splenocytes, and the apoptotic rate of splenocytes in DM + LDR groups increase significantly. However, as compared with those in the DM group, the percentages of TCR α β, CD4 + and CD8 + T cells and the splenocyte apoptotic rates in the DM+LDR groups decrease while the content of IL-2 and the ratio of CD4 + /CD8 + T cells increase. It is obvious that the multiple LDR could regulate and weaken the loss of BW and increase of BG caused by DM, correct the imbalance of lymphocyte subgroups and immune factors, decrease the increment of splenocyte apoptosis resulted from DM. Multiple LDR could result in body protection. (authors)

  20. Indifference to pain syndrome in a twelve-year-old boy (case report

    Directory of Open Access Journals (Sweden)

    Baghdadi T

    2007-08-01

    Full Text Available Background: People vary greatly in their response to painful stimuli, from those with a low pain threshold to those with indifference to pain. However, insensitivity to pain is a rare disorder, characterized by the lack of usual subjective and objective responses to noxious stimuli. Patients who have congenital indifference to pain sustain painless injuries beginning in infancy, but have sensory responses that are otherwise normal on examination. Perception of passive movement, joint position, and vibration is normal in these patients, as are tactile thresholds and light touch perception. Case report: A twelve-year-old boy was admitted to the hospital for a painless deformity, degeneration in both knees and a neglected femoral neck fracture that was inappropriately painless. Further examination revealed normal sensory responses, perception of passive movement, joint position, vibration tactile thresholds and light touch perception. Spinal cord and brain MRI were normal as was the electromyography and nerve conduction velocity (EMG/NCV examination. There was no positive family history for this disorder. Conclusion: The deficits present in the different pain insensitivity syndromes provide insight into the complex anatomical and physiological nature of pain perception. Reports on pain asymbolia, in which pain is perceived but does not cause suffering, and related cortical conditions illustrate that there can be losses that independently involve either the sensory-discriminative component or the affective-motivational component of pain perception, thus highlighting their different anatomical localization. The paucity of experience with this entity and the resultant diagnostic problems, the severity of the associated disabling arthropathy and underscore the importance of this case report of indifference to pain.

  1. A survey of innovation through duplication in the reduced genomes of twelve parasites.

    Directory of Open Access Journals (Sweden)

    Jeremy D DeBarry

    Full Text Available We characterize the prevalence, distribution, divergence, and putative functions of detectable two-copy paralogs and segmental duplications in the Apicomplexa, a phylum of parasitic protists. Apicomplexans are mostly obligate intracellular parasites responsible for human and animal diseases (e.g. malaria and toxoplasmosis. Gene loss is a major force in the phylum. Genomes are small and protein-encoding gene repertoires are reduced. Despite this genomic streamlining, duplications and gene family amplifications are present. The potential for innovation introduced by duplications is of particular interest. We compared genomes of twelve apicomplexans across four lineages and used orthology and genome cartography to map distributions of duplications against genome architectures. Segmental duplications appear limited to five species. Where present, they correspond to regions enriched for multi-copy and species-specific genes, pointing toward roles in adaptation and innovation. We found a phylum-wide association of duplications with dynamic chromosome regions and syntenic breakpoints. Trends in the distribution of duplicated genes indicate that recent, species-specific duplicates are often tandem while most others have been dispersed by genome rearrangements. These trends show a relationship between genome architecture and gene duplication. Functional analysis reveals: proteases, which are vital to a parasitic lifecycle, to be prominent in putative recent duplications; a pair of paralogous genes in Toxoplasma gondii previously shown to produce the rate-limiting step in dopamine synthesis in mammalian cells, a possible link to the modification of host behavior; and phylum-wide differences in expression and subcellular localization, indicative of modes of divergence. We have uncovered trends in multiple modes of duplicate divergence including sequence, intron content, expression, subcellular localization, and functions of putative recent duplicates that

  2. The Impact of the Financial Crisis on the Content of Twelve Bestselling US Principles of Economics Textbooks

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    2013-01-01

    How have authors of twelve bestselling introductory US textbooks in economics responded to the traumatizing financial crisis? In general the financial crisis is described with a couple of lines here and there or it is dealt with in boxes, separate sections, or specific isolated chapters. Some...

  3. Comparisons of High School Graduation Rates of Students with Disabilities and Their Peers in Twelve Southern States

    Science.gov (United States)

    Smith, Theodore Scott; Manuel, Nancy; Stokes, Billy R.

    2012-01-01

    This study compared differences in diploma and graduation dropout rates among students with and without disabilities, analyzed differences in various graduation-types by disabilities, and offered recommendations to improve graduation rates through evidence-based practices. The geographic catchment area of this study was limited to twelve Southern…

  4. A revision of Metaleptobasis Calvert (Odonata: Coenagrionidae) with seven synonymies and the description of eighteen new species from South America.

    Science.gov (United States)

    Von Ellenrieder, Natalia

    2013-11-25

    Examination of over 1,400 specimens of the neotropical genus Metaleptobasis Calvert, 1907, including primary types or paratypes of 18 of the 20 currently available species names and large series of specimens including pairs in tandem and copula, allowed me to unequivocally associate older names with species, distinguish between specific and intraspecific variability, associate both sexes for each species, and recognize the existence of female polymorphism. As a result, seven names are found to be junior synonyms: Metaleptobasis mauritia Williamson, 1915 junior synonym of M. bicornis (Selys, 1877), M. manicaria Williamson, 1915 and M. fernandezi Rácenis, 1955 junior synonyms of M. diceras (Selys, 1877), M. westfalli Cumming, 1954 junior synonym of M. foreli Ris, 1915, and M. tetragena Calvert, 1947, M. weibezahni Rácenis, 1955, and M. incisula De Marmels, 1989 junior synonyms of M. brysonima Williamson, 1915. Lectotypes are designated for M. amazonica and Leptobasis diceras. Eighteen new species of Metaleptobasis are described: M. brevicauda (Holotype ♂, Peru, Huánuco Dep., Shapajilla, jungle, 11 v 1939, F. Woytkowski leg., in UMMZ); M. falcifera (Holotype ♂, Peru, Madre De Dios Dep., Pakitza, Reserved Zone, Manu National Park, T2 to R2 to T1 to base camp, 11°55'48''S, 71°15'18''W, 250 m, 17 ix 1989, J.A. Louton leg., in USNM); M. furcifera (Holotype ♂, Peru, Loreto Dep., Iquitos, iii 1936, G.G. Klug leg., in BMNH); M. gabrielae (Holotype ♂, Peru, Loreto Dep., Tamshiyacu-Tahuayo Reserve, forest interior (4°23'40''S, 73°14'56''W), 27 vii 2009, T. Faasen leg., in RMNH); M. guillermoi (Holotype ♂, Peru, Loreto Dep., Yarinacocha, temporary forest stream (8°17'S, 74°37'W, 145 m), 2 vi 1972, D.L. Pearson leg., in FSCA); M. inermis (Holotype ♂, Brazil, Pará State, Jacareacanga, vii 1969, F.R. Barbosa leg., in UMMZ); M. leniloba (Holotype ♂, Peru, Loreto Dep., Pacaya-Samiria National Reserve, Santa Luisa trail (5°15'S, 74°40'W), 10 vi 2008, C

  5. Risk factors for chronic noncontiguous diseases: Twelve-week prospective study

    Directory of Open Access Journals (Sweden)

    Lapčević Mirjana

    2004-01-01

    basis of RF number and combination for genesis and development of CND in our sample, 74.7% of variability (development or risk may be accounted for angina pectoris (AP, 74.2% for DM+HTA, 70.0% for DM, 79.9% for HTA, 80.8% for myocardial infarction (Ml, and 85.8% of variability (development or risk for cerebrovascular insult (CVI. Twelve-week intervention resulted in reduction of HTA, HLP, glucose, and PC (p<0.001 levels as well as lower BMI and PA (p<0.5. To accomplish the aforementioned goals, continuous mutual activity of an individual, his/her family, health service and community is required, along with occasional evaluation of the obtained results.

  6. Tanzania national survey on iodine deficiency: impact after twelve years of salt iodation

    Directory of Open Access Journals (Sweden)

    Kimboka Sabas

    2009-09-01

    Full Text Available Abstract Background In many low-income countries, children are at high risk of iodine deficiency disorders, including brain damage. In the early 1990s, Tanzania, a country that previously suffered from moderate to severe iodine deficiency, adopted universal salt iodation (USI as an intervention strategy, but its impact remained unknown. Methods We report on the first national survey in mainland Tanzania, conducted in 2004 to assess the extent to which iodated salt was used and its apparent impact on the total goitre prevalence (TGP and urinary iodine concentrations (UIC among the schoolchildren after USI was initiated. In 2004, a cross-sectional goitre survey was conducted; covering 140,758 schoolchildren aged 6 - 18 years were graded for goitre according to new WHO goitre classification system. Comparisons were made with district surveys conducted throughout most of the country during the 1980s and 90s. 131,941 salt samples from households were tested for iodine using rapid field test kits. UIC was determined spectrophotometrically using the ammonium persulfate digestion method in 4523 sub-sampled children. Results 83.6% (95% CI: 83.4 - 83.8 of salt samples tested positive for iodine. Whereas the TGP was about 25% on average in the earlier surveys, it was 6.9% (95%CI: 6.8-7.0 in 2004. The TGP for the younger children, 6-9 years old, was 4.2% (95%CI: 4.0-4.4, n = 41,965. In the 27 goitre-endemic districts, TGP decreased from 61% (1980s to 12.3% (2004. The median UIC was 204 (95% CF: 192-215 μg/L. Only 25% of children had UIC Conclusion Our study demonstrates a marked improvement in iodine nutrition in Tanzania, twelve years after the initiation of salt iodation programme. The challenge in sustaining IDD elimination in Tanzania is now two-fold: to better reach the areas with low coverage of iodated salt, and to reduce iodine intake in areas where it is excessive. Particular attention is needed in improving quality control at production level and

  7. Two-dimensional liquid chromatography consisting of twelve second-dimension columns for comprehensive analysis of intact proteins.

    Science.gov (United States)

    Ren, Jiangtao; Beckner, Matthew A; Lynch, Kyle B; Chen, Huang; Zhu, Zaifang; Yang, Yu; Chen, Apeng; Qiao, Zhenzhen; Liu, Shaorong; Lu, Joann J

    2018-05-15

    A comprehensive two-dimensional liquid chromatography (LCxLC) system consisting of twelve columns in the second dimension was developed for comprehensive analysis of intact proteins in complex biological samples. The system consisted of an ion-exchange column in the first dimension and the twelve reverse-phase columns in the second dimension; all thirteen columns were monolithic and prepared inside 250 µm i.d. capillaries. These columns were assembled together through the use of three valves and an innovative configuration. The effluent from the first dimension was continuously fractionated and sequentially transferred into the twelve second-dimension columns, while the second-dimension separations were carried out in a series of batches (six columns per batch). This LCxLC system was tested first using standard proteins followed by real-world samples from E. coli. Baseline separation was observed for eleven standard proteins and hundreds of peaks were observed for the real-world sample analysis. Two-dimensional liquid chromatography, often considered as an effective tool for mapping proteins, is seen as laborious and time-consuming when configured offline. Our online LCxLC system with increased second-dimension columns promises to provide a solution to overcome these hindrances. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Energy, a networked Europe - Twelve proposals for a common energy infrastructure policy

    International Nuclear Information System (INIS)

    Derdevet, Michel

    2015-01-01

    energies (wind, photovoltaic), but also the emergence of new uses, such as electric vehicles. - Ensuring solidarity between the States and regions, in a context where the technological uncertainties of the new sectors are added to the older ones of a geopolitical nature. - Continuing to ensure equal access to energy services, without the transition becoming a discriminating factor against those citizens who are economically the weakest. Pooling knowledge and thinking to adapt the networks is a necessity if the Europeans want the energy transition to be a success. Article 194 of the Treaty of Lisbon has already laid down the way to greater intervention by the Union in this regard. But the Europeans must go further and explore, as quickly as possible, areas of joint cooperation, innovation and investment. The challenge is great since hundreds of billions of euros of investment will have to be made between now and 2030, and no argument is needed to convince oneself that, in a convalescent Europe, every euro will have to be invested with the greatest concern for effectiveness for our communities. Finally, this 'networked European energy', that we all wish for, will not only be a physical, technical and economic challenge. It must also embody these 'shared idiosyncrasies' that today characterise the European energy space: the verticality of the national hierarchies will be followed by the horizontality of communication between the territories; the authority of the powers in place, by the legitimacy of the citizen, initiative and success; industrial uniformity, by the diversity of models of organisation; a situation of separate States, by exchanges within the European area. The twelve proposals presented at the end of this report thus aim to promote the emergence of a coherent and pragmatic European approach in the field of networks, to solve today's problems and to meet tomorrow's challenges. From this standpoint, these proposals are structured

  9. Do supervised weekly exercise programs maintain functional exercise capacity and quality of life, twelve months after pulmonary rehabilitation in COPD?

    Directory of Open Access Journals (Sweden)

    Alison Jennifer A

    2007-05-01

    Full Text Available Abstract Background Pulmonary rehabilitation programs have been shown to increase functional exercise capacity and quality of life in COPD patients. However, following the completion of pulmonary rehabilitation the benefits begin to decline unless the program is of longer duration or ongoing maintenance exercise is followed. Therefore, the aim of this study is to determine if supervised, weekly, hospital-based exercise compared to home exercise will maintain the benefits gained from an eight-week pulmonary rehabilitation program in COPD subjects to twelve months. Methods Following completion of an eight-week pulmonary rehabilitation program, COPD subjects will be recruited and randomised (using concealed allocation in numbered envelopes into either the maintenance exercise group (supervised, weekly, hospital-based exercise or the control group (unsupervised home exercise and followed for twelve months. Measurements will be taken at baseline (post an eight-week pulmonary rehabilitation program, three, six and twelve months. The exercise measurements will include two six-minute walk tests, two incremental shuttle walk tests, and two endurance shuttle walk tests. Oxygen saturation, heart rate and dyspnoea will be monitored during all these tests. Quality of life will be measured using the St George's Respiratory Questionnaire and the Hospital Anxiety and Depression Scale. Participants will be excluded if they require supplemental oxygen or have neurological or musculoskeletal co-morbidities that will prevent them from exercising independently. Discussion Pulmonary rehabilitation plays an important part in the management of COPD and the results from this study will help determine if supervised, weekly, hospital-based exercise can successfully maintain functional exercise capacity and quality of life following an eight-week pulmonary rehabilitation program in COPD subjects in Australia.

  10. Accumulation of aluminum and barium in twelve Punjab wheat varieties and their contents in the agricultural soil

    International Nuclear Information System (INIS)

    Shar, G.Q.; Lashari, A.K.H.; Haider, S.I.

    2003-01-01

    Wheat samples of twelve varieties, grown by breeders at NIAB, Faisalabad Pakistan and its soil, were collected and analyzed for aluminum and barium content by atomic absorption spectroscopy using acetylene-nitroxide flame. For dissolution for heavy metals, aluminum and barium, wet acid digestion method was used. The experimental study was conducted using six samples for each twelve varieties of FSC and RD (Federal Seed Certification and Registration Department) as standard reference materials and representative samples, and the soil which was also collected from agricultural plot of Nuclear Inst. of Agricultural and Biology (NIAB), Faisalabad, Punjab. The characteristics mean of both elements in each variety of representative samples was found to be 28.32, 71.02, 37.41, 36.95, 28.32, 47.40, 30.14, 14.69, 25.41, 32.86, 30.14 and 41.95 for the aluminum and 12.67, 6.92, 5.67, 19.82, 3.28, 17.34, 10.25, 10.49, 8.01, 14.23, 15.16 and 6.92 mg/kg for the barium of Chakwal-86, Bakhatawar-92, Shahkar-95, Parwaz-94, Punjab-96, Bahawal pur-97, Shahkar-91, Inquilab-91, Pasban-90, Punjab-85, Faisalabad-85 and Pak-81 varieties respectively. The soil of that specific plot contains 35964.3 and 111.08 mg/kg of aluminum and barium respectively. The representative samples, which are compared with certified samples at 95% confidence limit. The purpose of this study was to study the variation in uptake of aluminum and barium in twelve different wheat varieties grown in same agricultural plot. (author)

  11. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    International Nuclear Information System (INIS)

    MORGAN, R.G.

    1999-01-01

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve

  12. Risk assessment of K basin twelve-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-04-06

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rates which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations suggest that only the valve's bonnet and stem are exposed above the basin concrete floor. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this activity are to: (1) evaluate the risk of damaging the three twelve-inch drain valves located along the north wall of the main basin from a seismic initiating event, and (2) determine the associated potential leak rate from a damaged valve.

  13. Model of twelve properties of a set of organic solvents with graph-theoretical and/or experimental parameters.

    Science.gov (United States)

    Pogliani, Lionello

    2010-01-30

    Twelve properties of a highly heterogeneous class of organic solvents have been modeled with a graph-theoretical molecular connectivity modified (MC) method, which allows to encode the core electrons and the hydrogen atoms. The graph-theoretical method uses the concepts of simple, general, and complete graphs, where these last types of graphs are used to encode the core electrons. The hydrogen atoms have been encoded by the aid of a graph-theoretical perturbation parameter, which contributes to the definition of the valence delta, delta(v), a key parameter in molecular connectivity studies. The model of the twelve properties done with a stepwise search algorithm is always satisfactory, and it allows to check the influence of the hydrogen content of the solvent molecules on the choice of the type of descriptor. A similar argument holds for the influence of the halogen atoms on the type of core electron representation. In some cases the molar mass, and in a minor way, special "ad hoc" parameters have been used to improve the model. A very good model of the surface tension could be obtained by the aid of five experimental parameters. A mixed model method based on experimental parameters plus molecular connectivity indices achieved, instead, to consistently improve the model quality of five properties. To underline is the importance of the boiling point temperatures as descriptors in these last two model methodologies. Copyright 2009 Wiley Periodicals, Inc.

  14. Eighteen Years of Safe Storage and Counting

    Energy Technology Data Exchange (ETDEWEB)

    Moren, Richard J. [Mission Support Alliance; Morton, M. [Polestar Technical Services, INC

    2016-03-28

    The purpose of this paper is to share the status and condition of the six reactor buildings at the Hanford Site in Washington State that are in this SAFSTOR condition (for between 4 and 18 years as of summer of 2016).

  15. The world in eighteen lessons: Christopher Williams

    NARCIS (Netherlands)

    Berrebi, S.

    2011-01-01

    Conceptual photographer Christopher Williams is a real artist's artist. Ever since he moved to Germany, his measured work, which both reveres and examines the art of photography, has more and more easily found its way into European art institutes, such as this spring at Museum Dhondt-Dhaenens in

  16. Agronomic characterization of eighteen cucurbitaceae cultivars used ...

    African Journals Online (AJOL)

    SARAH

    2014-09-30

    Sep 30, 2014 ... Faculty of Sciences and Technology at Abdou Moumouni. University of ..... information on seeds form highlighted lying seeds (ratio less than 1) for all .... ERP- value. -. 0.0926. 0.7146. FLO -. 0.3711. 0.1295. 0.1499. 0.5528.

  17. Identification and characterization of eighteen polymorphic ...

    Indian Academy of Sciences (India)

    Author Affiliations. Fei Xiong1 Hong-Yan Liu1 Xin-Bin Duan2 Da-Qing Chen2. College of Life Sciences, Jianghan University, Wuhan 430056, People's Republic of China; Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, People's Republic of China ...

  18. Training course for eighteen teachers at CERN

    CERN Multimedia

    Laurianne Noemie Trimoulla

    2015-01-01

    From 8 to 10 December, 18 teachers from all over France attended a three-day training course on matter, organised by the LAMAP Foundation (Fondation La main à la pâte, see here) and hosted by CERN and S'Cool Lab. The LAMAP Foundation, set up by Georges Charpak in 1995, aims to help primary school teachers use the investigative process to instil the scientific spirit in their pupils.      Fired by curiosity and eager to learn, the teachers were introduced to the many and varied activities on offer at CERN, including the cloud chamber experiment, the Masterclass programme and the "Be a physicist" learning scheme. They particularly enjoyed their tours of Microcosm, the Synchrocyclotron and the ATLAS visitor centre, which stimulated many questions. They are eagerly looking forward to passing on their newly found knowledge to their pupils and perhaps even inspiring some to take up a career in physics! Last but not least, they were treat...

  19. Eighteen polymorphic microsatellites for domestic pigeon Columba ...

    Indian Academy of Sciences (India)

    certain parasites which cause health problems in humans and domestic animals ... The genomic DNA was isolated using standard protocol as described by ..... panel of polymorphic microsatellite markers in Himalayan monal. Lophophorus ...

  20. The social, cultural and medicinal use of kava for twelve Tongan born men living in Auckland, New Zealand.

    Science.gov (United States)

    Nosa, Vili; Ofanoa, Malakai

    2009-02-01

    Kava consumption is a very popular practise amongst Pacific people especially amongst the Tongan communities. The purpose of this paper is to identify some of the key cultural, social and medicinal elements of kava use amongst Tongan men. Twelve face to face interviews in this study were undertaken. The paper argues that kava drinking is strongly linked to many of the ceremonial, social and cultural obligations that are deeply embedded within the Tongan culture. The positive uses of kava include medicinal purposes, male bonding, alternative to alcohol consumption, reaffirming and establishing relationships amongst other Tongan men, The men also stated negative uses of kava such as it made them lazy, tired so they were not able to go to work, a lack of sexual activities by being too tired have sex with their partners, and very expensive to buy in New Zealand. The aim of this paper is to discuss and examine the social, cultural and medicinal kava use amongst twelve Tongan born men living in Auckland, New Zealand. The study used qualitative methods, specifically individual interviews were conducted in Tongan or English. Participants were recruited through community networks in Auckland. A number of Tongan churches, Tongan medical clinics such as Langimailie, and kava clubs were approached to recruit participants. The open ended interview schedule covered themes such as access, quantity, frequency, and problems associated with kava use. The interviews were conducted by a Tongan researcher either in English or Tongan. All interviews were translated and transcribed into English. A thematic analysis based on multiple readings of the transcripts was used The analysis identified commonalities and differences. The study was granted ethical approval by the University of Auckland Human Subjects Ethics Committee in December 2004. Interviews were conducted at the beginning of 2005. Interviews were undertaken in a place where the participants felt comfortable. Interview times

  1. Surgical Approach, Findings, and Eight-Year Follow-Up in a Twenty-Nine Year Old Female With Freeman-Sheldon Syndrome Presenting With Blepharophimosis Causing Near-Complete Visual Obstruction.

    Science.gov (United States)

    Portillo, Augusto L; Poling, Mikaela I; McCormick, Rodger J

    2016-07-01

    The authors describe the surgical approach, findings, and 8-year follow-up in a 29-year-old woman, with severe Freeman-Sheldon syndrome, presenting with congenital blepharophimosis of both upper eyelids resulting in near-complete functional visual obstruction. To avoid possible Freeman-Sheldon syndrome-associated complications of malignant hyperthermia, difficult vascular access, and challenging endotracheal intubation, the surgery was completed under local anesthesia without sedation, and anatomical and functional correction was immediate and remained stable at 8-year follow-up. Unlike many congenital craniofacial syndromes, which frequently involve life-long impairments, important implications exist for plastic surgeons to facilitate opportunities for patients to overcome functional limitations.

  2. Vibrational modes of isolated substitution impurities in twelve compounds AN B8-N with the blende structure

    International Nuclear Information System (INIS)

    Plumelle, Pierre

    1979-01-01

    We have studied a particular point defect, the isolated substitution in twelve compounds CuCl, CuBr, CuI, ZnTe, CdTe, ZnS, ZnSe, GaAs, GaP, InSb, InP and GaSb. The model of the perfect lattice is a rigid ion model with eleven parameters. Infrared localized vibrational modes of impurities are observed in a series of samples. By comparison of these experimental results with the calculated values it is possible to determine the perturbation for each particular case. A relation obtained between a force constant of the perfect crystal and the force constant of the impurity suggests that no change is introduced by the isoelectronic impurities. (author) [fr

  3. Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Allen, David; Milanowski, Janusz

    2004-01-01

    , exacerbations, and requirements for oral steroid treatment and more symptom-free days and days without use of rescue treatment. CONCLUSIONS: Twelve months of treatment with inhaled FP (100 microg twice daily) in preschool children aged 1 to 3 years with recurrent wheeze has no effect on growth and no other......OBJECTIVE: Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze. METHODS: The study was a randomized, parallel-group, open-label multicenter study of 625 children......, aged 1 to 3 years, with recurrent wheeze randomized in a 3:1 ratio to treatment for 52 weeks with FP (100 microg twice daily) via metered-dose inhaler and Babyhaler spacer device or SCG (5 mg 4 times daily) via metered-dose inhaler and Nebuhaler spacer device, respectively. RESULTS...

  4. Twelve month follow-up on a randomised controlled trial of relaxation training for post-stroke anxiety.

    Science.gov (United States)

    Golding, Katherine; Fife-Schaw, Chris; Kneebone, Ian

    2017-09-01

    To follow up participants in a randomised controlled trial of relaxation training for anxiety after stroke at 12 months. Twelve month follow-up to a randomised controlled trial, in which the control group also received treatment. Community. Fifteen of twenty one original participants with post-stroke anxiety participated in a one year follow-up study. A self-help autogenic relaxation CD listened to five times a week for one month, immediately in the intervention group and after three months in the control group. Hospital Anxiety and Depression Scale-Anxiety subscale and the Telephone Interview of Cognitive Status for inclusion. Hospital Anxiety and Depression Scale-Anxiety subscale for outcome. All measures were administered by phone. Anxiety ratings reduced significantly between pre and post-intervention, and between pre-intervention and one year follow-up ( χ 2 (2) = 22.29, p autogenic relaxation CD appear to be maintained after one year.

  5. Metagenomic binning reveals the functional roles of core abundant microorganisms in twelve full-scale biogas plants

    DEFF Research Database (Denmark)

    Campanaro, Stefano; Treu, Laura; Kougias, Panagiotis

    2018-01-01

    and environmental factors on MAGs abundance and to investigate the methanogenic performance of the biogas plants. Prediction of the functional properties of MAGs was obtained analyzing their KEGG pathways and their carbohydrate active domains. Network analysis allowed investigation of species-species associations......The aim of this work was to elucidate the microbial ecology in twelve mesophilic and thermophilic full-scale biogas plants using a genome-centric metagenomic approach. In this study both biogas plants treating manure and those treating sludge from waste water treatment plants were considered...... and shed light on syntrophic interactions between members belonging to the anaerobic digestion dark matter (phylum Fermentibacteria). By stratifying and comparing different levels of information, it was predicted that some MAGs have a crucial role in the manure-supplemented thermophilic biogas plants...

  6. Nucleic acids in mummified plant seeds: screening of twelve specimens by gel-electrophoresis, molecular hybridization and DNA cloning.

    Science.gov (United States)

    Rollo, F; La Marca, A; Amici, A

    1987-02-01

    Twelve seed specimens of varying ages and from different archaeological sites were analyzed for the presence of polymerized DNA and RNA. Amongst the samples tested, one of Vitis vinifera from an archaeological site in Iran (2,000-3,000 B.C.) was found to be completely devoid of nucleic acids. Zea mais seeds of Precolumbial age from Peru (about 800 A.D.) contained depolymerized DNA and RNA. Samples of Vitis vinifera and Rubus sp. from a Lombard archaeological site (800 A.D.) as well as radiocarbon dated seeds from the site of the "Spring Sanctuary" near Metaponto (I-IV century B.C.) were found to contain polymerized DNA and rRNA bands. However the electrophoretic properties of the rRNAs in one case and hybridization experiments performed with cloned seed DNA in the other, clearly demonstrated that the polymerized nucleic acids were not of plant origin.

  7. Developing and Testing Twelve-Step Facilitation for Adolescents with Substance Use Disorder: Manual Development and Preliminary Outcomes

    Directory of Open Access Journals (Sweden)

    John F. Kelly

    2016-01-01

    Full Text Available Adolescent substance use disorder treatment programs are often based on the 12-step philosophy of Alcoholics Anonymous and/or link adolescents to these free resources. Despite this, no studies have developed and rigorously tested a twelve-step facilitation (TSF intervention for young people, leaving a significant evidence gap. This study describes the first systematic development of an outpatient adolescent TSF treatment. An integrated twelve-step facilitation (iTSF treatment incorporated TSF, motivational enhancement therapy, and cognitive behavioral therapy elements and was developed in an iterative manner with weekly feedback provided by 36 adolescents ( M age 17 years [SD = 1.4]; 52.8% white with DSM-IV substance use disorder recruited from the community. Assessments were conducted at baseline and at three and six months. Participants completed 6 of 10 sessions on average (8 participants completed all 10. Notable treatment developments were the inclusion of “in-services” led by Marijuana Anonymous members, including parents in a portion of individual sessions to provide a rationale for TSF, and use of a Socratic therapeutic interaction style. Acceptability and feasibility of the treatment were excellent (treatment satisfaction was 4.29 [SD = 0.59] out of 5. In keeping with TSF theory, the intervention substantially increased 12-step participation, and greater participation related to greater abstinence. iTSF is a replicable manualized treatment that can be implemented and tested in outpatient settings. Given the widespread compatibility of iTSF with the current adolescent treatment, if found efficacious, iTSF could be relatively easily adopted, implemented, and sustained and could provide an evidence-based option that could undergird current practice.

  8. Twelve tips for blueprinting.

    Science.gov (United States)

    Coderre, Sylvain; Woloschuk, Wayne; McLaughlin, Kevin

    2009-04-01

    Content validity is a requirement of every evaluation and is achieved when the evaluation content is congruent with the learning objectives and the learning experiences. Congruence between these three pillars of education can be facilitated by blueprinting. Here we describe an efficient process for creating a blueprint and explain how to use this tool to guide all aspects of course creation and evaluation. A well constructed blueprint is a valuable tool for medical educators. In addition to validating evaluation content, a blueprint can also be used to guide selection of curricular content and learning experiences.

  9. Study of the efficiency of AgCl, In2O3, Ga2O3, NaF, LiF and SrF2 as spectrographic carriers in the quantitative analysis of eighteen microcompound elements in uranium

    International Nuclear Information System (INIS)

    Gomes, R.P.; Lordello, A.R.; Abrao, A.

    1977-01-01

    A comparative study of the efficiency of some spectrochemical carriers (AgCl, In 2 O 3 , Ga 2 O 3 , NaF, LiF and SrF 2 ) is presented for the quantitative spectrographic analysis of Ag, Al, B, Bi, Cd, Cr, Cu, Fe, Mg, Mn, Mo, Ni, P, Pb, Si, Sn, V and Zn in uranium and its compounds. The volatility behaviour of the eighteen elements was verified by means of the moving plate technique for each of the mentioned carriers. The final aim was the selection of the carriers for the determination of trace amounts of the impurities. The best results were obtained with 4% In 2 O 3 , 6% AgCl and 6% NaF in a U 3 O 8 matrix. The sensitivities for some elements were extended to fractions of p.p.m. The precision, accuracy and acceptability of the method were calculated for all elements. The total error values are approximately in the range of 16-45% [pt

  10. In vitro and genetic diversity studies of twelve accessions of aerial yams (D. bulbifera and D. alata) in Ghana

    International Nuclear Information System (INIS)

    Katsekpor, C.

    2014-07-01

    Aerial yams (D. bulbifera and D. alata) are usually among the dioscoreaceae, in that they are cultivated not only for their tubers but also for the bulbils that develop at the leaf axils of the vine. Twelve accessions collected from five geographic regions were evaluated for morphological characteristics. The results indicate that the 12 accessions exhibited similarity with respect to 11 traits but were variable with respect to 5. Bulbils from the twelve accessions of aerial yams collected from the experimental field, were analysed for proximate composition including moisture, crude protein, crude ash, crude fat, crude fibre and carbohydrate content using the Association of Official Analytical Chemist (AOAC) method. Elemental composition of the bulbils was also determined through instrumental neutron activation analysis (INAA). Accession S recorded the highest crude protein (6.77 %), crude fibre (3.38 %) and carbohydrate (25.39 %) contents. Bulbils from D, G and T recorded the highest crude fat (0.56 %), moisture (72.97 %) and crude ash (7.96 %) content respectively. Accession V recorded the highest amount of magnesium (143.43 mg/100g), potassium (2644.4 mg/100g), chlorine (3272.2 mg/100g) and copper (1.116 mg/100g). Bulbils from accession F also recorded the highest amount of aluminum (5.26 mg/100g) and manganese (0.43 mg/100g), while accession B, C, E and R also recorded highest percentages of vanadium (0.037 mg/100g), sodium (26.63 mg/100g), calcium (333.5 mg/100g) and zinc (4.53 mg/100g) respectively. Nodal explants of 12 accessions of the aerial yam were cultured in vitro on Murashige and Skoog (MS) medium supplemented with varying concentrations of kinetin with or without activated charcoal, as assessed for ability to regenerate plantlets with distinct shoots, leaves and roots. The highest regeneration of plantlets was achieved at kinetin concentration of 2.0 mg/l with activated charcoal. Kinetin concentration beyond 2.0 mg/l proved to be phytotoxic and

  11. Uptake of radionuclide thorium by twelve native plants grown in uranium mill tailings soils from south part of China

    International Nuclear Information System (INIS)

    Yan, Xun

    2016-01-01

    Highlights: • Screen dominant plants grown in uranium mill tailings soils. • Quantify the content of "2"3"2Th of soil samples from uranium mill tailings. • Quantify the transfer factor, bioconcentration factor and phytoremediation factor. • Screen out the plant species capable of remediating radionuclide contaminated soils. • Guide the reuse of study area in future. - Abstract: The concentrations of thorium ("2"3"2Th) in soil from a uranium mill tailings repository in South China were analyzed. The results showed that all the soil samples were acidic and the concentrations of "2"3"2Th in all the soil samples were more than the natural radionuclide content in soil of China. Through the field investigation, twelve kinds of dominant plants were discovered. The total quantity of "2"3"2Th in the whole plant is highest in rice flat sedge. We also found that Miscanthus floridulus has the greatest transfer factor (TF) for "2"3"2Th, rice flat sedge has the greatest bioconcentration factor (BF) for "2"3"2Th. At the mean time, M. floridulus has the greatest phytoremediation factor (PF) for "2"3"2Th. On the basis of the above conclusions and the definition for hyperaccumulator, rice flat sedge and M. floridulus could be the candidates of phytoremediation for radionuclide "2"3"2Th in the soil.

  12. Measuring performance in off-patent drug markets: a methodological framework and empirical evidence from twelve EU Member States.

    Science.gov (United States)

    Kanavos, Panos

    2014-11-01

    This paper develops a methodological framework to help evaluate the performance of generic pharmaceutical policies post-patent expiry or after loss of exclusivity in non-tendering settings, comprising five indicators (generic availability, time delay to and speed of generic entry, number of generic competitors, price developments, and generic volume share evolution) and proposes a series of metrics to evaluate performance. The paper subsequently tests this framework across twelve EU Member States (MS) by using IMS data on 101 patent expired molecules over the 1998-2010 period. Results indicate that significant variation exists in generic market entry, price competition and generic penetration across the study countries. Size of a geographical market is not a predictor of generic market entry intensity or price decline. Regardless of geographic or product market size, many off patent molecules lack generic competitors two years after loss of exclusivity. The ranges in each of the five proposed indicators suggest, first, that there are numerous factors--including institutional ones--contributing to the success of generic entry, price decline and market penetration and, second, MS should seek a combination of supply and demand-side policies in order to maximise cost-savings from generics. Overall, there seems to be considerable potential for faster generic entry, uptake and greater generic competition, particularly for molecules at the lower end of the market. Copyright © 2014. Published by Elsevier Ireland Ltd.

  13. Twelve-year follow-up of a randomized controlled trial of comprehensive physiotherapy following disc herniation operation.

    Science.gov (United States)

    Ebenbichler, Gerold R; Inschlag, Silke; Pflüger, Verena; Stemberger, Regina; Wiesinger, Günther; Novak, Klaus; Christoph, Krall; Resch, Karl L

    2015-06-01

    To evaluate the long-term effects of postoperative comprehensive physiotherapy starting one week after lumbar disc surgery. Twelve-year follow-up of a three-armed, randomized, controlled, single-blinded clinical trial. Department of Physical Medicine & Rehabilitation. Of 111 patients following first-time, uncomplicated lumbar disc surgery who participated in the original study and completed the treatment originally allocated, 74 ((67%; 29 (73%) physiotherapy, 22 (58%) sham therapy, 23 (68%) no therapy) completed a 12-year follow-up examination. In the original study, patients had been randomly assigned to comprehensive physiotherapy, sham intervention (neck massage), or no therapy. Low Back Pain Rating Scale; best score 0, worst score 130 points). At 12 years after surgery, the group participating in comprehensive physiotherapy had significantly better functional outcomes, as rated on the Low Back Pain Rating Score, than the untreated group (mean difference: -13.2 (95% CI: (-25.4; -1.0)). Equally, there was a clinically relevant, non-significant difference between the sham therapy and no therapy (mean difference: -12.5 (95%CI: -26.1; 1.1)). Consequently, the Low Back Pain Rating Score outcome did not differ between physiotherapy and sham therapy (mean difference: -0.7 (95%CI: -14.2; 12.8)). Participating in a comprehensive physiotherapy program following lumbar disc surgery may be associated with better long-term health benefits over no intervention, but may not be superior to sham therapy. © The Author(s) 2014.

  14. Pilot Testing a Photo-Based Food Diary in Nine- to Twelve- Year Old- Children from Dunedin, New Zealand

    Directory of Open Access Journals (Sweden)

    Brittany K. Davison

    2018-02-01

    Full Text Available The purpose of the study was to investigate if an Evernote app-based electronic food diary is an acceptable method to measure nutrient intake in children aged 9–12 years. A convenience sample of 16 nine- to twelve-year-olds from Dunedin, New Zealand, completed a paper-based food dairy on four days, followed by four more days using a photo-based diary on an iPod. This photo-based diary used a combination of photographs and short written descriptions of foods consumed. The photo-based diaries produced similar results to written diaries for all macronutrients and major micronutrients (e.g., calcium, fibre, vitamin C. Spearman correlation coefficients between the two methods for all nutrients, except sugars, were above 0.3. However, burden on researchers and participants was reduced for the photo-based diary, primarily due to the additional information obtained from photographs. Participating children needed less help from parents with completing the electronic diaries and preferred them to the paper version. This electronic diary is likely to be suitable, after additional formal validity testing, for use in measuring nutrient intake in children.

  15. Effect of the composition of extra virgin olive oils on the differentiation and antioxidant capacities of twelve monovarietals.

    Science.gov (United States)

    Fuentes, Edwar; Paucar, Fiorela; Tapia, Francisco; Ortiz, Jaime; Jimenez, Paula; Romero, Nalda

    2018-03-15

    The effect of the composition of twelve varieties of extra virgin olive oils (EVOOs) on their differentiation based in agronomic criteria and on the antioxidant capacity was studied. Principal component analysis permitted an overview of the samples and their compositions, showing evidence of grouping and correlation between antioxidant capacity, oleuropein and ligstroside derivatives (OLD) and specific extinction at 270. Oleic and linoleic acids, 3,4-DHPEA-EA and p-HPEA-EDA (OLD), unsaturated/saturated ratio and induction time (IT) allowed the correct classification of samples according to year of harvest, ripening stage and variety. The antioxidant capacity of EVOOs was satisfactory predicted through a partial least square model based on ΔK, hydroxytyrosol, pinoresinol, oleuropein derivate and IT. Validation of the model gave a correlation R>0.83 and an error of 7% for independent samples. This model could be a useful tool for the olive industry to highlight the nutritional quality of EVOOs and improve their marketing. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Bright ideas: Twelve steps to break our energy addiction - with technologies and policy options that are available today

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-12-31

    The deleterious effects of excessive energy use, the effects of climate change and Canadian commitments under the Kyoto Protocol are discussed. The discussion takes the form of a series of recommendations to show that contrary to skeptics, it is possible to achieve our Kyoto commitments and even exceed them, with technology already at our disposal. A series of twelve recommendations are made, each recommendation accompanied by a brief discussion of its major virtues and contributions to a more sustainable energy future. The recommendations are: (1) reward efficiency and responsibility; (2) set mandatory efficiency targets for industry; (3) build more efficient and livable cities; (4) impose fuel efficiency standards; (5) increase funding for public transportation; (6) improve freight transportation; (7) adopt energy-efficient building code standards for new buildings; (8) introduce a national retrofit program for existing buildings; (9) set higher efficiency standards for appliances; (10) support the renewable energy industry; (11) reduce demand for electric power; and (12) implement a renewable portfolio standard.

  17. Uptake of radionuclide thorium by twelve native plants grown in uranium mill tailings soils from south part of China

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Xun, E-mail: m13836295186@163.com

    2016-08-01

    Highlights: • Screen dominant plants grown in uranium mill tailings soils. • Quantify the content of {sup 232}Th of soil samples from uranium mill tailings. • Quantify the transfer factor, bioconcentration factor and phytoremediation factor. • Screen out the plant species capable of remediating radionuclide contaminated soils. • Guide the reuse of study area in future. - Abstract: The concentrations of thorium ({sup 232}Th) in soil from a uranium mill tailings repository in South China were analyzed. The results showed that all the soil samples were acidic and the concentrations of {sup 232}Th in all the soil samples were more than the natural radionuclide content in soil of China. Through the field investigation, twelve kinds of dominant plants were discovered. The total quantity of {sup 232}Th in the whole plant is highest in rice flat sedge. We also found that Miscanthus floridulus has the greatest transfer factor (TF) for {sup 232}Th, rice flat sedge has the greatest bioconcentration factor (BF) for {sup 232}Th. At the mean time, M. floridulus has the greatest phytoremediation factor (PF) for {sup 232}Th. On the basis of the above conclusions and the definition for hyperaccumulator, rice flat sedge and M. floridulus could be the candidates of phytoremediation for radionuclide {sup 232}Th in the soil.

  18. Dual-resolution Raman spectroscopy for measurements of temperature and twelve species in hydrocarbon–air flames

    Energy Technology Data Exchange (ETDEWEB)

    Magnotti, Gaetano; Barlow, Robert S.

    2016-07-12

    This study introduces dual-resolution Raman spectroscopy as a novel diagnostics approach for measurements of temperature and species in flames where multiple hydrocarbons are present. Simultaneous measurement of multiple hydrocarbons is challenging because their vibrational Raman spectra in the C–H stretch region are closely overlapped and are not well known over the range of temperature encountered in flames. Overlap between the hydrocarbon spectra is mitigated by adding a second spectrometer, with a higher dispersion grating, to collect the Raman spectra in the C–H stretch region. A dual-resolution Raman spectroscopy instrument has been developed and optimized for measurements of major species (N2, O2, H2O, CO2, CO, H2, DME) and major combustion intermediates (CH4, CH2O, C2H2, C2H4 and C2H6) in DME–air flames. The temperature dependences of the hydrocarbon Raman spectra over fixed spectral regions have been determined through a series of measurements in laminar Bunsen-burner flames, and have been used to extend a library of previously acquired Raman spectra up to flame temperature. The paper presents the first Raman measurements of up to twelve species in hydrocarbon flames, and the first quantitative Raman measurements of formaldehyde in flames. Lastly, the accuracy and precision of the instrument are determined from measurements in laminar flames and the applicability of the instrument to turbulent DME–air flames is discussed.

  19. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease' in Italy

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Marques Lourenço, Charles; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Le Quan Sang, Kim-Hanh; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650–85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy. PMID:25804398

  20. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.

    Science.gov (United States)

    Nemethova, Martina; Radvanszky, Jan; Kadasi, Ludevit; Ascher, David B; Pires, Douglas E V; Blundell, Tom L; Porfirio, Berardino; Mannoni, Alessandro; Santucci, Annalisa; Milucci, Lia; Sestini, Silvia; Biolcati, Gianfranco; Sorge, Fiammetta; Aurizi, Caterina; Aquaron, Robert; Alsbou, Mohammed; Lourenço, Charles Marques; Ramadevi, Kanakasabapathi; Ranganath, Lakshminarayan R; Gallagher, James A; van Kan, Christa; Hall, Anthony K; Olsson, Birgitta; Sireau, Nicolas; Ayoob, Hana; Timmis, Oliver G; Sang, Kim-Hanh Le Quan; Genovese, Federica; Imrich, Richard; Rovensky, Jozef; Srinivasaraghavan, Rangan; Bharadwaj, Shruthi K; Spiegel, Ronen; Zatkova, Andrea

    2016-01-01

    Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-tyrosine catabolic pathway. We analysed DNA of 40 AKU patients enrolled for SONIA1, the first study in DevelopAKUre, and of 59 other AKU patients sent to our laboratory for molecular diagnostics. We identified 12 novel DNA variants: one was identified in patients from Brazil (c.557T>A), Slovakia (c.500C>T) and France (c.440T>C), three in patients from India (c.469+6T>C, c.650-85A>G, c.158G>A), and six in patients from Italy (c.742A>G, c.614G>A, c.1057A>C, c.752G>A, c.119A>C, c.926G>T). Thus, the total number of potential AKU-causing variants found in 380 patients reported in the HGD mutation database is now 129. Using mCSM and DUET, computational approaches based on the protein 3D structure, the novel missense variants are predicted to affect the activity of the enzyme by three mechanisms: decrease of stability of individual protomers, disruption of protomer-protomer interactions or modification of residues in the region of the active site. We also present an overview of AKU in Italy, where so far about 60 AKU cases are known and DNA analysis has been reported for 34 of them. In this rather small group, 26 different HGD variants affecting function were described, indicating rather high heterogeneity. Twelve of these variants seem to be specific for Italy.

  1. The poetics of comic in the «The Twelve Chairs» novel (to the problem of a funny word

    Directory of Open Access Journals (Sweden)

    Kildyaeva Yu.I.

    2017-05-01

    Full Text Available the article deals with the role of a funny word in the comic structure of «The Twelve Chairs» by I. Ilf and E. Petrov. The researcher reveals its different functions taking into account authors’ strategy, directed to the creation of a special type of comic.

  2. Two new genera and twelve new species of Graphidaceae from Puerto Rico: a case for higher endemism of lichenized fungi in islands of the Caribbean?

    Science.gov (United States)

    Joel A. Mercado-Diaz; Robert Lücking; Sittiporn Parnmen

    2014-01-01

    Two new genera and twelve new species of Graphidaceae are described from Puerto Rico. The two new genera, Borinquenotrema and Paratopeliopsis, are based on a combination of molecular sequence data and phenotype characters. Borinquenotrema, with the single new species B. soredicarpum, features rounded ascomata developing beneath and persistently covered with soralia and...

  3. The great controversy : the individual's struggle between good and evil in the Testaments of the Twelve Patriarchs and in their Jewish and Christian contexts

    NARCIS (Netherlands)

    Bruin, Tom de

    2013-01-01

    The Testaments of the Twelve Patriarchs are an early Christian work. The argumentation in this work finds its foundation in the struggle between good and evil. In the Testaments this struggle is applied individually, which is a theme found only in Christian works.

  4. SU-F-T-491: Photon Beam Matching Analysis at Multiple Sites Up to Twelve Years Post Installation

    Energy Technology Data Exchange (ETDEWEB)

    Able, C [Florida Cancer Specialists - New Port Richey, New Port Richey, FL (United States); Zakikhani, R [Florida Cancer Specialists - Largo, Largo, FL (United States); Yan, K [Florida Cancer Specialists- Tampa, Tampa, FL (United States); Sha, D [Florida Cancer Specialist - New Port Richey, New Port Richey, FL (United States); Chopra, A [Florida Cancer Specialist - Brooksville, Spring Hill, FL (United States)

    2016-06-15

    Purpose: To determine if the photon beams associated with several models of accelerators are matched with ‘Golden Beam’ data (VGBD) to assess treatment planning modeling and delivery. Methods: Six accelerators’ photon beams were evaluated to determine if they matched the manufacturer’s (Varian Medical Systems, Inc.) VGBD. Additional direct comparisons of the 6X and 18X beams using the manufacturer’s specification of Basic and Fine beam matching were also performed. The Cseries accelerator models were 21 EX (3), IX (2), and a IX Trilogy, ranging from three to twelve years post installation. Computerized beam scanning was performed (IBA Blue Phantom 2) with 2 CC13 ion chambers in water at 100 cm SSD. Dmax (10 cm2 field size), percentage depth dose (6 cm2, 10 cm2, 20 cm2, and 30 cm2 field sizes) and beam uniformity (10 cm2, 30 cm2 and 40 cm2 field sizes) were evaluated. Results: When comparing the beams with VGBD using the ‘Basic’ matching criteria, all beams were within the specifications ( 1.5mm at dmax, 1% PDD, and 2% Profiles). When considering the “Fine” matching criteria ( 1.5mm at dmax, 0.5% PDD, and 2% Profiles), only three of six 6MV beams and two of six high energy (five 18MV & one 15MV) beams passed. Direct comparisons between accelerators using the Clinac IX (installed 2012) as the reference beam datasets resulted in all 6 MV and 18MV beams meeting both the “Basic” and “Fine” criterion with the exception of two accelerators. Conclusion: Linear accelerators installed up to nine years apart are capable of meeting the manufacturers beam matching criteria for “Basic” matching. Without any adjustments most beams, when evaluated, may meet the “Fine” match criteria. The use of a single dataset (VGBD or designated accelerator reference data) for treatment planning commissioning is acceptable and can provide quality treatment delivery.

  5. Genetic Variability Studies on Twelve Genotypes of Rice (Oryza sativa L. for Growth and Yield Performance in South Eastern Nigeria

    Directory of Open Access Journals (Sweden)

    Vincent N. ONYIA

    2017-03-01

    Full Text Available Twelve genotypes of rice collected from the National Cereals Research Institute (NCRI, Badeggi, Bida, Niger State, Nigeria were evaluated to estimate the magnitude of genetic variability and relationship of some agronomic traits of rice and their contributions to yield. The results obtained showed a significant difference (p ≤ 0.05 among the genotypes in all the traits studied. Genotype ‘WAB 35-1-FX2’ produced a significantly higher grain yield of 3.40 t/ha compared with all the other genotypes in the two years combined. Genotypes ‘WAB 33-25’, ‘WAB 56-1-FX2’, ‘WAB 56-39’, ‘WAB 56-125’, ‘ITA 150’ and ‘FAROX 16 (LC’ were the most stable grain yielding genotypes across the two years of the experiment. High broad sense heritability (h2bs was associated with grain yield (h2bs = 98.63%, number of spikelets/panicle (98.78%, plant height (98.34% for the first year planting, whereas in the second year planting, days to 50% flowering (96.72%, days to maturity (94.14% and grain yield (83.33% were among the traits that showed high broad sense heritability. The two years combined correlation analysis showed that grain yield correlated significantly and positively with number of spikelets/panicle (r = 0.2358*, number of panicles/m2 (r = 0.1895*, number of fertile spikelets/panicle (r = 0.1672* and 1,000 grain weight (r = 0.1247*, indicating that these traits can be phenotypic basis for improving grain yield of rice. Conversely, grain yield exhibited negative correlation with days to 50% flowering (-0.3009 and days to maturity (-0.2650, though not significant. This suggests that rice grain yield can be improved by selecting early flowering and maturing genotypes especially under heat and drought prone conditions.

  6. Effectiveness of community-based treatment for problem gambling: a quasi-experimental evaluation of cognitive-behavioral vs. twelve-step therapy.

    Science.gov (United States)

    Toneatto, Tony; Dragonetti, Rosa

    2008-01-01

    With the increasing availability of gambling throughout North America, there is interest in developing more effective treatments. This study compares the effectiveness of two brief outpatient treatments for problem gambling: eight sessions of Cognitive-Behavioral Therapy (n = 65) and eight sessions of a twelve-step treatment-oriented approach based on the first five steps of Gamblers Anonymous (n = 61). There were no baseline group differences on gambling-relevant variables. Twelve months post-treatment showed no group differences on key gambling variables (eg, frequency, abstinence rates, money wagered) in an analysis of completers. Participants who attended more sessions and chose an initial abstinent treatment goal appeared to achieve better outcomes.

  7. Evaluation agriculture morphological and analysis of yield components in twelve cañahua agreements (Chenopodium pallidicaule Aellen

    Directory of Open Access Journals (Sweden)

    Mayta-Mamani Adelio

    2015-11-01

    Full Text Available In the present investigation, they were carried out the analysis descriptive statistic, variance analysis, comparison of stockings of Duncan, multiple correlation and analysis of path coefficient, this I finish to determine the direct and indirect effects, in cañahua (Chenopodium pallidicaule Aellen. The study behaved at random under the design of blocks with four repetitions and twelve treatments (cañahua agreements, during the campaign agricultural 2009 and 2010. The results show, the grain production on the average general of 7.67 grain/plant, with a coefficient of variability of 23.1%, and with better yields they were the agreements 455, 222, ILLPA-INIA and CUPI, achieved to produce 12.28 grain/plant on the average, 10.58 grain/plant, 10.29 grain/plant and 10.16 grain/plant, respectively. Through the path analysis, selection approaches the components of yields were identified. In the agreement 455, the coefficient of determination of the system plants dear it reached 36.5%, and main yield components were constituted, number of branches, vegetable covering and height of the plant, with an association degree and direct effect of r=0.505 P=0.327, r=0.446 P=0.168 and r=0.417 P=0.196, respectively. In the agreement 222, the characters morphological that influence in the yield this explained in 40.5%, and as better yield component the number of branches has been constituted (r=0.462 (P=0.261, vegetable covering (r=0.514 (P=0.271 and height of the plant (r=0.383 (P=0.047. In the agreement ILLPA-INIA, it has been determined as better yield component, the number of branches (r=0.514 (P=0.318 and diameter of the shaft (r=0.479 (P=0.524, these characters in its group justify that the system plants defined total it was 44.7% of the direct influence. Agreement CUPI, in this cultivation the characters that influenced in the grain yield are implied in 36.4% and with better characters morphological that have been able to influence in a direct way they are

  8. Ultra pressure liquid chromatography-negative electrospray ionization mass spectrometry determination of twelve halobenzoquinones at ng/L levels in drinking water.

    Science.gov (United States)

    Huang, Rongfu; Wang, Wei; Qian, Yichao; Boyd, Jessica M; Zhao, Yuli; Li, Xing-Fang

    2013-05-07

    We report here the characterization of twelve halobenzoquinones (HBQs) using electrospray ionization (ESI) high resolution quadrupole time-of-flight mass spectrometry. The high resolution negative ESI spectra of the twelve HBQs formed two parent ions, [M + H(+) + 2e(-)], and the radical M(-•). The intensities of these two parent ions are dependent on their chemical structures and on instrumental parameters such as the source temperature and flow rate. The characteristic ions of the HBQs were used to develop an ultra pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. At the UPLC flow rate (400 μL/min) and under the optimized ESI conditions, eleven HBQs showed the stable and abundant transitions [M + H(+) + 2e(-)] → X(-) (X(-) representing Cl(-), Br(-), or I(-)), while dibromo-dimethyl-benzoquinone (DBDMBQ) showed only the transition of M(-•) → Br(-). The UPLC efficiently separates all HBQs including some HBQ isomers, while the MS/MS offers exquisite limits of detection (LODs) at subng/mL levels for all HBQs except DBDMBQ. Combined with solid phase extraction (SPE), the method LOD is down to ng/L. The results from analysis of authentic samples demonstrated that the SPE-UPLC-MS/MS method is reliable, fast, and sensitive for the identification and quantification of the twelve HBQs in drinking water.

  9. Increased strength of the scapular stabilizer and lumbar muscles after twelve weeks of Pilates training using the Reformer machine: A pilot study.

    Science.gov (United States)

    Dos Santos, Núbia Tomain Otoni; Raimundo, Karoline Cipriano; da Silva, Sheila Aparecida; Souza, Lara Andrade; Ferreira, Karoline Carregal; Borges Santo Urbano, Zuleika Ferreira; Gasparini, Andréa Licre Pessina; Bertoncello, Dernival

    2017-01-01

    The aim of this work was to analyze muscle strength in Pilates novices who used the Reformer equipment during twelve training sessions. Twenty-four healthy young female volunteers, who were non-smokers and did not exercise regularly, were split into a control group (mean age 28 ± 4 years and BMI 24.55 ± 3.21 kg/m 2 ) and a training group (mean age 29 ± 4 years and BMI 22.69 ± 2.87 kgm 2 ). The data were checked for normality using the Kolmogorov-Smirnov test, and were then analyzed using the t-test (p Pilates group). The corresponding values for the lumbar muscles were 53.83 ± 11.66/53.28 ± 11.14 (control group) and 54.75 ± 10.27/64.80 ± 10.20 (Pilates group). After twelve sessions of Pilates with the Reformer equipment, there were improvements in lumbar extensor and scapular stabilizer strength. Several benefits are reported by practitioners of Pilates, but until now, there has been limited scientific evidence of the improvement of strength in the trunk and limbs after application of the technique. Published by Elsevier Ltd.

  10. A Comparative Study of the Self-Esteem of Adolescent Boys with and without Learning Disabilities in an Inclusive School

    Science.gov (United States)

    Ntshangase, Sibusiso; Mdikana, Andile; Cronk, Candice

    2008-01-01

    Participants in this study were twenty-nine adolescent boys (n = 29) between the ages of sixteen and eighteen years, who were attending an inclusive private school in the affluent suburb of Johannesburg. Fourteen participants had never been diagnosed with learning difficulties and had attended mainstream schools throughout their school careers.…

  11. Risk assessment of K Basin twelve-inch and four-inch drain valve failure from a postulated seismic initiating event

    Energy Technology Data Exchange (ETDEWEB)

    MORGAN, R.G.

    1999-06-23

    The Spent Nuclear Fuel (SNF) Project will transfer metallic SNF from the Hanford 105 K-East and 105 K-West Basins to safe interim storage in the Canister Storage Building in the 200 Area. The initial basis for design, fabrication, installation, and operation of the fuel removal systems was that the basin leak rate which could result from a postulated accident condition would not be excessive relative to reasonable recovery operations. However, an additional potential K Basin water leak path is through the K Basin drain valves. Three twelve-inch drain valves are located in the main basin bays along the north wall. Five four-inch drain valves are located in the north and south loadout pits (NLOP and SLOP), the weasel pit, the technical viewing pit, and the discharge chute pit. The sumps containing the valves are filled with concrete which covers the drain valve body. Visual observations indicate that only the valve's bonnet and stem are exposed above the basin concrete floor for the twelve-inch drain valve and that much less of the valve's bonnet and stem are exposed above the basin concrete floor for the five four-inch drain valves. It was recognized, however, that damage of the drain valve bonnet or stem during a seismic initiating event could provide a potential K Basin water leak path. The objectives of this analysis are to: (1) evaluate the likelihood of damaging the three twelve-inch drain valves located along the north wall of the main basin and the five four-inch drain valves located in the pits from a seismic initiating event, and (2) determine the likelihood of exceeding a specific consequence (initial leak rate) from a damaged valve. The analysis process is a risk-based uncertainty analysis where each variable is modeled using available information and engineering judgement. The uncertainty associated with each variable is represented by a probability distribution (probability density function). Uncertainty exists because of the inherent

  12. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation

    Science.gov (United States)

    Ndunguru, Joseph; Sseruwagi, Peter; Tairo, Fred; Stomeo, Francesca; Maina, Solomon; Djinkeng, Appolinaire; Kehoe, Monica; Boykin, Laura M.

    2015-01-01

    Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) which are frequently found infecting cassava, one of sub-Saharan Africa’s most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production. PMID:26439260

  13. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation.

    Directory of Open Access Journals (Sweden)

    Joseph Ndunguru

    Full Text Available Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV and Ugandan cassava brown streak virus (UCBSV which are frequently found infecting cassava, one of sub-Saharan Africa's most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production.

  14. How can general paediatric training be optimised in highly specialised tertiary settings? Twelve tips from an interview-based study of trainees.

    Science.gov (United States)

    Al-Yassin, Amina; Long, Andrew; Sharma, Sanjiv; May, Joanne

    2017-01-01

    Both general and subspecialty paediatric trainees undertake attachments in highly specialised tertiary hospitals. Trainee feedback suggests that mismatches in expectations between trainees and supervisors and a perceived lack of educational opportunities may lead to trainee dissatisfaction in such settings. With the 'Shape of Training' review (reshaping postgraduate training in the UK to focus on more general themes), this issue is likely to become more apparent. We wished to explore the factors that contribute to a positive educational environment and training experience and identify how this may be improved in highly specialised settings. General paediatric trainees working at all levels in subspecialty teams at a tertiary hospital were recruited (n=12). Semistructured interviews were undertaken to explore the strengths and weaknesses of training in such a setting and how this could be optimised. Appreciative inquiry methodology was used to identify areas of perceived best practice and consider how these could be promoted and disseminated. Twelve best practice themes were identified: (1) managing expectations by acknowledging the challenges; (2) educational contracting to identify learning needs and opportunities; (3) creative educational supervision; (4) centralised teaching events; (5) signposting learning opportunities; (6) curriculum-mapped pan-hospital teaching programmes; (7) local faculty groups with trainee representation; (8) interprofessional learning; (9) pastoral support systems; (10) crossover weeks to increase clinical exposure; (11) adequate clinical supervision; and (12) rota design to include teaching and clinic time. Tertiary settings have strengths, as well as challenges, for general paediatric training. Twelve trainee-generated tips have been identified to capitalise on the educational potential within these settings. Trainee feedback is essential to diagnose and improve educational environments and appreciative inquiry is a useful tool for

  15. Twelve tips for assessment psychometrics.

    Science.gov (United States)

    Coombes, Lee; Roberts, Martin; Zahra, Daniel; Burr, Steven

    2016-01-01

    It is incumbent on medical schools to show, both to regulatory bodies and to the public at large, that their graduating students are "fit for purpose" as tomorrow's doctors. Since students graduate by virtue of passing assessments, it is vital that schools quality assure their assessment procedures, standards, and outcomes. An important part of this quality assurance process is the appropriate use of psychometric analyses. This begins with development of an empowering, evidence-based culture in which assessment validity can be demonstrated. Preparation prior to an assessment requires the establishment of appropriate rules, test blueprinting and standard setting. When an assessment has been completed, the reporting of test results should consider reliability, assessor, demographic, and long-term analyses across multiple levels, in an integrated way to ensure the information conveyed to all stakeholders is meaningful.

  16. Twelve tips for the top

    Energy Technology Data Exchange (ETDEWEB)

    Cranfield, J; Buckman, D

    1994-09-01

    Exploration has shown the presence of oil and gas in a number of new offshore sites around the world, those in the Caspian Sea appearing to be the most promising the water generally being shallow enough for economic development by Western technology. The potential for oil and gas development is outlined for each of the following countries; Azerbaijan; Turkmenistan; Kazakstan; Iran; Italy; Croatia; Namibia; Equatorial Guinea; Sudan; Bangladesh; Myanmar; Cambodia. (UK)

  17. Stress, burnout and doctors' attitudes to work are determined by personality and learning style: a twelve year longitudinal study of UK medical graduates.

    Science.gov (United States)

    McManus, I C; Keeling, A; Paice, E

    2004-08-18

    The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style.

  18. Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates

    Directory of Open Access Journals (Sweden)

    Paice E

    2004-08-01

    Full Text Available Abstract Background The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Methods Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire, burnout (Maslach Burnout Inventory, and satisfaction with medicine as a career and personality (Big Five. Previous questionnaires had included measures of learning style (Study Process Questionnaire and personality. Results Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Conclusions Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style.

  19. Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation.

    Science.gov (United States)

    Thomsen, Cathrine; Haug, Line S; Stigum, Hein; Frøshaug, May; Broadwell, Sharon L; Becher, Georg

    2010-12-15

    At present, scientific knowledge on depuration rates of persistent organic pollutants (POPs) is limited and the previous assumptions of considerable reduction of body burdens through breast-feeding have recently been challenged. We therefore studied elimination rates of important POPs in nine Norwegian primiparous mothers and one mother breast-feeding her second child by collecting breast-milk samples (n = 70) monthly from about two weeks to up to twelve months after birth. Perfluorinated compounds (PFCs), polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD), and polychlorinated biphenyls (PCBs) were determined in the breast-milk samples. Linear mixed effect models were established for selected compounds, and significant decreases in the range of 1.2-4.7% in breast-milk concentrations per month were observed for a wide range of PCBs and PBDEs. For the first time, depuration rates for perfluorooctylsulfonate (PFOS) and perfluorooctanoic acid (PFOA) are presented, being 3.8 and 7.8% per month, respectively (p changes during the lactation period. After a year of nursing the breast-milk concentrations of PFCs, PBDEs, and PCBs were reduced by 15-94%.

  20. 希纳斯特拉《十二首美洲前奏曲》音乐概述%Ginastera's Twelve American Prelude Music Overview

    Institute of Scientific and Technical Information of China (English)

    郝梦

    2011-01-01

    Twelve American Preludes is composed during the "objective nationalism period" of Ginastera.Composer selected the Latin American folk music which reflected the Indian factors,Europe Iberian factors and African blacks factor.They represent the different types of music genre form.Through highly Abstract and summarizes the main music characteristics of music carrier,and put these ethnic music elements into modern music creation techniques,its own peculiar national writing style is formed.%《十二首美洲前奏曲》属于希纳斯特拉"客观民族主义时期"的音乐作品。作曲家选取了拉丁美洲民族民间音乐中体现拉丁美洲音乐构成的印第安元素、欧洲伊比利亚元素、非洲黑人元素中具有代表性的不同类型的音乐体裁形式,高度抽象地概括出这些音乐体裁的主要音乐特点,并将这些民族音乐元素融入现代音乐创作技法中,形成特有的民族创作风格。

  1. Challenge of goodness: twelve humanitarian proposals based on the experience of 1991-1995 wars in Croatia and Bosnia and Herzegovina.

    Science.gov (United States)

    Lang, S

    1998-03-01

    Based on the 1991-1995 war experience of peoples of Croatia and Bosnia and Herzegovina, I made twelve proposals regarding the following aspects of health, humanitarian work, and human rights: 1. Broadening of the WHO definition of health by including spiritual well-being (absence of hatred) in it, 2. Inclusion of the term genocide into the Index Medicus (MeSH), 3. Establishment of concepts of prevention of hate, 4. Right to a home, 5. Right of civilians to participate in defense and renewal, 6. Right to deliberation from enslavement and right to find out the fate of missing persons, 7. Global hospital, 8. Monitoring of prisoner-of-war camps, 9. Refugee camps, 10. Providing of care for the abandoned - a new category of people suffering in war, 11. Introduction of the Helping Hand concept, 12. Organization of the Red Cross Forum after the cessation of hostilities. The fundamental objective was to establish the legitimacy of honesty in practice, regulative social mechanisms, and science.

  2. Stress, burnout and doctors' attitudes to work are determined by personality and learning style: A twelve year longitudinal study of UK medical graduates

    Science.gov (United States)

    McManus, IC; Keeling, A; Paice, E

    2004-01-01

    Background The study investigated the extent to which approaches to work, workplace climate, stress, burnout and satisfaction with medicine as a career in doctors aged about thirty are predicted by measures of learning style and personality measured five to twelve years earlier when the doctors were applicants to medical school or were medical students. Methods Prospective study of a large cohort of doctors. The participants were first studied when they applied to any of five UK medical schools in 1990. Postal questionnaires were sent to all doctors with a traceable address on the current or a previous Medical Register. The current questionnaire included measures of Approaches to Work, Workplace Climate, stress (General Health Questionnaire), burnout (Maslach Burnout Inventory), and satisfaction with medicine as a career and personality (Big Five). Previous questionnaires had included measures of learning style (Study Process Questionnaire) and personality. Results Doctors' approaches to work were predicted by study habits and learning styles, both at application to medical school and in the final year. How doctors perceive their workplace climate and workload is predicted both by approaches to work and by measures of stress, burnout and satisfaction with medicine. These characteristics are partially predicted by trait measures of personality taken five years earlier. Stress, burnout and satisfaction also correlate with trait measures of personality taken five years earlier. Conclusions Differences in approach to work and perceived workplace climate seem mainly to reflect stable, long-term individual differences in doctors themselves, reflected in measures of personality and learning style. PMID:15317650

  3. Barley husk carbon as the fiber coating for the solid-phase microextraction of twelve pesticides in vegetables prior to gas chromatography-mass spectrometric detection.

    Science.gov (United States)

    Liang, Weiqian; Wang, Juntao; Zang, Xiaohuan; Dong, Wenhuan; Wang, Chun; Wang, Zhi

    2017-03-31

    In this work, a barley husk biomaterial was successfully carbonized by hydrothermal method. The carbon had a high specific surface area and good stability. It was coated onto a stainless steel wire through sol-gel technique to prepare a solid-phase microextraction fiber for the extraction of trace levels of twelve pesticides (tsumacide, fenobucarb, indoxacarb, diethofencarb, thimet, terbufos, malathion, thiamethoxam, imidacloprid, buprofezin, acetamiprid, thiamethoxam) from vegetable samples prior to gas chromatography-mass spectrometric (GC-MS) detection. The main experimental parameters that could influence the extraction efficiency such as extraction time, extraction temperature, sample pH, sample salinity, stirring rate, desorption temperature and desorption time, were investigated. Under the optimized conditions, the linearity was observed in the range of 0.2-75.0μgkg -1 for tomato samples, and 0.3-60.0μgkg -1 for cucumber samples, with the correlation coefficients (r) ranging from 0.9959 to 0.9983. The limits of detection of the method were 0.01-0.05μgkg -1 for tomato samples, and 0.03-0.10μgkg -1 for cucumber samples. The recoveries of the analytes for the method from spiked samples were in the range of 76%-104%, and the precision, expressed as the relative standard deviations, was less than 12%. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Transfer of eleven species of the genus Burkholderia to the genus Paraburkholderia and proposal of Caballeronia gen. nov. to accommodate twelve species of the genera Burkholderia and Paraburkholderia.

    Science.gov (United States)

    Dobritsa, Anatoly P; Samadpour, Mansour

    2016-08-01

    It has been proposed to split the genus Burkholderia into two genera according to phylogenetic clustering: (1) a genus retaining this name and consisting mainly of animal and plant pathogens and (2) the genus Paraburkholderia including so-called environmental bacteria. The latter genus name has been validly published recently. During the period between the effective and valid publications of the genus name Paraburkholderia, 16 novel species of the genus Burkholderiawere described, but only two of them can be classified as members of this genus based on the emended genus description. Analysis of traits and phylogenetic positions of the other 11 species shows that they belong to the genus Paraburkholderia, and we propose to transfer them to this genus. The reclassified species names are proposed as Paraburkholderia dipogonis comb. nov., Paraburkholderia ginsengiterrae comb. nov., Paraburkholderia humisilvae comb. nov., Paraburkholderia insulsa comb. nov., Paraburkholderia kirstenboschensis comb. nov., Paraburkholderia metalliresistens comb. nov., Paraburkholderia monticola comb. nov., Paraburkholderia panaciterrae comb. nov., Paraburkholderia rhizosphaerae comb. nov., Paraburkholderia solisilvae comb. nov. and Paraburkholderia susongensis comb. nov. The remaining three species are transferred to the new genus Caballeronia gen. nov. proposed to accommodate twelve species of the genera Burkholderia and Paraburkholderia forming a distinctive clade in phylogenetic trees. The new genus members are Caballeronia choica comb. nov., Caballeronia cordobensis comb. nov., Caballeronia glathei comb. nov., Caballeronia grimmiae comb. nov., Caballeronia humi comb. nov., Caballeronia megalochromosomata comb. nov., Caballeronia jiangsuensis comb. nov., Caballeronia sordidicola comb. nov., Caballeronia telluris comb. nov., Caballeronia terrestris comb. nov., Caballeronia udeis comb. nov., and Caballeronia zhejiangensis comb. nov.

  5. Twelve weeks of BodyBalance® training improved balance and functional task performance in middle-aged and older adults

    Directory of Open Access Journals (Sweden)

    Nicholson VP

    2014-11-01

    Full Text Available Vaughan P Nicholson, Mark R McKean, Brendan J Burkett School of Health and Sport Sciences, University of the Sunshine Coast, Sunshine Coast, QLD, Australia Purpose: The purpose of the study was to evaluate the effect of BodyBalance® training on balance, functional task performance, fear of falling, and health-related quality of life in adults aged over 55 years.Participants and methods: A total of 28 healthy, active adults aged 66±5 years completed the randomized controlled trial. Balance, functional task performance, fear of falling, and self-reported quality of life were assessed at baseline and after 12 weeks. Participants either undertook two sessions of BodyBalance per week for 12 weeks (n=15 or continued with their normal activities (n=13.Results: Significant group-by-time interactions were found for the timed up and go (P=0.038, 30-second chair stand (P=0.037, and mediolateral center-of-pressure range in narrow stance with eyes closed (P=0.017. There were no significant effects on fear of falling or self-reported quality of life.Conclusion: Twelve weeks of BodyBalance training is effective at improving certain balance and functional based tasks in healthy older adults. Keywords: postural control, yoga, tai chi, center of pressure, exercise

  6. A Randomized Controlled Trial of Puncturing and Bloodletting at Twelve Hand Jing Points to Treat Acute Carbon Monoxide Poisoning as Adjunct to First Aid Treatment: A Study Protocol

    Directory of Open Access Journals (Sweden)

    Ying Yue

    2015-01-01

    Full Text Available Background. Acute carbon monoxide poisoning (ACOP is a significant cause of morbidity and mortality in many countries. Twelve Hand Jing Points (THJP have been believed to be effective to treat all kinds of emergency calls in traditional Chinese medicine (TCM for more than 3000 years. This randomized controlled trial (RCT is designed to evaluate the effectiveness of THJP in curing acute carbon monoxide poisoning in first aid treatment. This paper reports the protocol of the trial. Methods/Design. This RCT is a multicenter, randomized, controlled study undergoing in China. The compliant patients are divided into the bloodletting group and standard of care group. With first aid treatments given to both of the groups, the bloodletting group is bleeding at THJP upon being hospitalized. Primary outcomes and secondary outcomes will be measured and compared between these two groups. Before treatment, immediately after treatment, and 30 minutes, 1 hour, and 4 hours after treatment, patients’ basic vital signs and state of consciousness were observed. Before treatment and 1 and 4 hours after treatment, carboxyhemoglobin concentration in venous blood samples was detected. Discussion. The objective of this study is to provide convincing evidence to clarify the efficacy and safety of THJP for early treatment of acute carbon monoxide poisoning.

  7. Technical Papers on the Eighteen Metallographic Group Meeting

    National Research Council Canada - National Science Library

    Roman, H

    1965-01-01

    The polishing and etching procedures for preparing metallic, ceramic and cermet specimens of nuclear materials using the Automet polisher are discussed with some typical examples of the excellent results obtained...

  8. [Tarantism in Spain in the eighteen century: latrodectism and suggestion].

    Science.gov (United States)

    Corral-Corral, I; Corral-Corral, C

    2016-10-16

    Tarantism is the disease caused by the bite of the tarantula, in which the music tarantella triggers an involuntary dance. It is known in Italy since the sixteenth century. To analyze the tarantism reported in Spain at the end of the eighteenth century, with special attention to its neurological aspects, and to propose its medical and psychopathological explanation. An epidemic of people affected by the tarantula bite occurred in Spain in 1782. Spanish doctors described appropriately the clinical effects, identical to those produced by the bite of the spider black widow (Latrodectus tredecimguttatus), which was at that time identified as a tarantula. The cases reported by Francisco Xavier Cid cured with the involuntary dance triggered by the tarantella, as was described in Italy since the sixteenth century. Our interpretation is that this curative effect of dance in Spain was induced by suggestion. In Spanish patients there were no behavioral disturbances, periodic recurrences or collective involvement as those reported by Italian authors, which suggest an hysterical phenomenon, probably a continuation of the dancing mania of the Middle Age. Tarantism reported in Spain in the eighteenth century includes two different phenomena: the systemic symptoms produced by the tarantula bite, which is actually latrodectism, and the curative effect of the tarantella, explained by suggestion. The psychiatric disturbances, with a hysterical nature, falsely associated to the tarantula bite, observed in Italy, were not present among the Spanish cases of tarantism in the eighteenth century.

  9. Eighteen years experience of granulocyte donations-acceptable donor safety?

    Science.gov (United States)

    Axdorph Nygell, Ulla; Sollén-Nilsson, Agneta; Lundahl, Joachim

    2015-10-01

    Granulocyte transfusions are given to patients with life-threatening infections, refractory to treatment. The donors are stimulated with corticosteroids ± granulocyte colony stimulating factor (G-CSF). However, data regarding the donors' safety is sparse. The objective was therefore to evaluate short- and long-term adverse events (AE) in G-CSF stimulated donors. All consecutive granulocyte donors from 1994 to 2012 were identified through our registry. From the donation records, the number of aphereses, stimulation therapy, AE, blood values post donation, and recent status were evaluated. One hundred fifty-four volunteer donors were mobilized for 359 collections. Age at first granulocyte donation was 43 years (median; range 19-64 years). Follow-up was 60 months (median; range 0-229 months). The dose of G-CSF per collection was 3.8 ug/kg body weight (median; range 1.6-6.0 ug/kg). Sedimentation agent was HES. Short-term AE were mild. Blood values 4 weeks post donation with minor reductions/elevations mostly resolved in later donations. Fourteen donors were excluded from the registry due to hypertension (4), diabetes (2), atrial flutter (1), breast carcinoma (1), urethral carcinoma in situ (1), MGUS (1), thrombosis (1), anaphylaxis (1), primary biliary cirrhosis (1), and unknown (1). Three donors are deceased due to diabetes, acute myocardial infarction, and unknown cause. All excluded/deceased donors except one were excluded/died at least 6 months after first granulocyte donation. No serious short-term AE were observed. Due to the variability of diagnoses among excluded/deceased donors, we propose that it is less likely that granulocyte donations have a causative impact on these donors' exclusion or death. © 2014 Wiley Periodicals, Inc.

  10. Results of TRT after eighteen months: our experience.

    Science.gov (United States)

    Baracca, Giovanna N; Forti, Stella; Crocetti, Andrea; Fagnani, Enrico; Scotti, Alberto; Del Bo, Luca; Ambrosetti, Umberto

    2007-05-01

    The aim of this study was to evaluate the efficacy of TRT in patients suffering from tinnitus. The tinnitus disorder affects about 10-15% of the population and, in one person out of a hundred, it is a disabling disorder. TRT treatment is based on Jastreboff's neurophysiological model. TRT consists of two parts: counselling, and sound therapy by means of dedicated hearing aids and sound generators. It proved to be useful to reduce the symptoms related to tinnitus. Jastreboff's structured interviews were proposed to a sample of 51 patients with tinnitus belonging to the I-II-III-IV classes according to Jastreboff. These patients were treated for 18 months. Sixty-eight percent of patients reported a reduction in the symptoms related to tinnitus, such as sleep disturbance, problems in concentration, and inability to relax. A percentage (64.7%) of patients thought that their quality of life was improved. Patients who had suffered from tinnitus for less than one year achieved significantly better results than patients who had suffered for a longer period of time. TRT is an effective tool in the treatment of tinnitus.

  11. 29 CFR 570.120 - Eighteen-year minimum.

    Science.gov (United States)

    2010-07-01

    ... general, they cover: No. 1. Occupations in or about plants manufacturing explosives or articles containing explosive components. No. 2. Occupations of motor-vehicle driver and helper. No. 3. Coal-mine occupations... power-driven metal forming, punching, and shearing machines. No. 9. Occupations in connection with...

  12. [Representatives of consumer associations and the "hôpital, patients, santé et territoires" law: an outline of the issues and twelve proposals].

    Science.gov (United States)

    Bréchat, Pierre-Henri; Gros, Jeannette; Haon, Michel; Jeunet, Odile; Magnin-Feysot, Christian

    2010-01-01

    Since 1996, consumers have been able to become involved in the development and implementation of national, regional and local healthcare policies, thereby demonstrating the possibility of establishing a model of democratic institution in healthcare at all levels of decision-making and policy implementation. Despite this 13-year political ambition, it is open to question whether the bill on the reform of the hospital will serve to extend the same dynamic for patients, healthcare institutions and local authorities. On 15 November 2008 and 18 April 2009, fifty-four consumer association representatives in the Franche-Comté region convened to conduct an audit of their commitments with a view to making proposals to adapt the bill aimed at reforming hospitals for the benefit of patients, healthcare and territories (HPST) before the bill is debated in Parliament (National Assembly and Senate). Despite significant investments since 1996 and some notable successes, for these representatives of consumer healthcare associations, the results are distinctly mixed. This is because they sometimes feel instrumentalized in healthcare facilities and believe that their opportunities for participation have declined since 2002. Their view is that this may diminish the power they wield at a time when the economy may be seen as becoming a substitute for public healthcare and participatory democracy. In a context of inequality in healthcare and at a time of economic crisis, this paradigm shift has tended to mobilize representatives of consumer associations. In their view, a strong counter-power is required to ensure fair and equal access to healthcare for all. They suggest twelve proposals concerning organization and professionalism at both territorial and national levels, articulated around the following principle : a representative of a consumers' association can become a regional reference in the management of the agency's regional healthcare system and may be given the means to

  13. Energy policies and the adaptations to the new economic framework: The case of twelve countries during the 1973-1983 period

    International Nuclear Information System (INIS)

    Bourgeois, B.; Criqui, P.; Percebois, J.

    1986-10-01

    Based upon case studies on twelve energy importing countries in 1973 (United States, Japan, Federal Republic of Germany, France, United Kingdom, Italy, Brazil, Argentina, Ivory Coast, India, South Korea and Thailand), this paper is an attempt to illustrate the diversity of national energy policies and industrial strategies which have been set up to adjust to the transformation of the world economy in the field of energy and international trade since 1973. Analysing some simple indicators such as the share of oil imports in total energy imports, the rate of national self-reliance for energy and the energy intensity of GDP, we show that the energy policies implemented in industrialised countries lead to quite homogeneous global results, whereas the responses of developing countries as regards oil shocks were more heterogeneous. Some countries have emphasized the decrease in the energy content of GDP whereas others have stressed the development of the national supply or the diversification of energy imports. The consequences of these choices will differ according to the future energy context (if there are sharp cuts in oil prices in particular). In all cases the influence of the socio-political and institutional context on energy options can be clearly observed. In a second part, we study the respective weight of energy and manufactured goods exchanges in the evolution of the balance of trade, using the following indicators: share of the energy and of the manufactured goods balance in total GDP and the ratio of the energy balance to the manufactured goods balance. Then very diverse situations can be observed. However four countries (Japan, FRG, Italy and South Korea) show rather similar features: a large manufactured goods surplus, which far exceeds the energy deficit. In other words some countries have chosen to compensate for their energy vulnerability by an aggressive commercial policy on external markets; on the contrary others have deliberately oriented

  14. Results of primary central nervous system lymphoma treated by radiation and chemotherapy. Retrospective analysis of twelve institutions in the Tokai district of Japan, 1995-1999

    International Nuclear Information System (INIS)

    Kawamura, Toshiki; Ishiguchi, Tsuneo; Shibamoto, Yuta

    2006-01-01

    We analyzed the therapeutic results and prognostic factors of 46 primary central nervous system lymphoma (PCNSL) patients who were treated at twelve institutions in the Tokai district of Japan between 1995 and 1999. We compared the results with those of a Japanese nationwide survey performed in the past. We sent each institution a questionnaire about the state of patients' disease, pathological type, method and doses of radiotherapy, regimen and intensity of chemotherapy, and patients' prognoses. The range of patients' ages was 33 to 93 years (median, 61 years). Thirty-one were men and 15 were women. The most prevalent histology was diffuse large B cell type (33 patients). We used the Kaplan-Meier method to calculate the survival rate and Cox's proportional hazards model to analyze the prognostic factors. The five-year cumulative survival rate was 25%, and the median survival time was 22.7 months. The five-year disease-free survival rate was 23%. In monovariate analysis, patients who were both younger than 60 years old and had a World Health Organization (WHO) performance status (PS) score equal to or less than 2 showed a better survival rate. Furthermore, the patients receiving systemic chemotherapy showed a significantly better local control rate. In addition, patients who received systemic chemotherapy achieved a higher complete remission rate than those not receiving it. However, no factors that significantly influenced survival rate were identified in multivariate analysis. We demonstrated that the therapeutic outcome of PCNSL patients has recently improved. In particular, patients with good PS showed better local control than those with poor PS. However, we could not identify any significant prognostic factors in PCNSL patients. (author)

  15. Blood Pressure, Sleep Quality and Fatigue in Shift Working Police Officers: Effects of a Twelve Hour Roster System on Cardiovascular and Sleep Health

    Directory of Open Access Journals (Sweden)

    Jaymen L. Elliott

    2016-01-01

    Full Text Available Background: Police officers have been reported to exhibit a high incidence of pathologies, which present prematurely in an otherwise healthy population. Shift work has also been associated with an increased risk of cardiovascular and sleep disorders, attributable to its propensity for circadian rhythm dysfunction. However, contention exists as to whether shift work has a direct effect upon blood pressure (BP regulation. Methods: This cross-sectional study sought to determine changes in BP and associations with the overall sleep quality and fatigue in 206 general duties police officers (n = 140 males of the New South Wales Police Force in Australia. The subjects’ BP was assessed before and after their twelve hour shift, during which time they also completed the Lifestyle Appraisal Questionnaire, Pittsburgh Sleep Quality Index (PSQI, Epworth Sleepiness Scale and Fatigue Severity Scale (FSS. Results: Poor sleep quality (PSQI and fatigue severity (FSS were found to predominate in the sample (69% and 51% respectively. Although there was no change in BP for male participants, female officers’ systolic blood pressure (SBP was found to increase significantly across the shift (p < 0.001, but with no change found in females’ diastolic blood pressure (DBP. Finally, higher pre and post-shift SBP (r = −0.26, p = 0.001; r = −0.25, p = 0.001, respectively and DBP (r = −0.26, p = 0.001; r = −0.26, p = 0.001, respectively were significantly correlated with lower FSS scores after accounting for age, waist-hip ratio and lifestyle risk factors. Conclusions: Based on these preliminary findings, there was a significant increase in SBP of female police officers after shift work, while BP and fatigue levels in all police officers were strongly related. Moreover, the predominating poor sleep quality and impact of fatigue in this sample remain a concern. Further research is required to ensure the physiological welfare of police officers, while strategies

  16. Twelve weeks of dance exergaming in overweight and obese adolescent girls: Transfer effects on physical activity, screen time, and self-efficacy.

    Science.gov (United States)

    Staiano, Amanda E; Beyl, Robbie A; Hsia, Daniel S; Katzmarzyk, Peter T; Newton, Robert L

    2017-03-01

    Given the low levels of physical activity (PA) among adolescent girls in the US, there is a need to identify tools to motivate increased PA. Although there is limited evidence that adolescents transfer PA from one context to another context, exergames (i.e., video games that require gross motor activity) may act as a gateway to promote overall PA outside of game play. The purpose of this study was to examine potential transfer effects (i.e., influences on external behaviors and psychological constructs) of a 12-week exergaming intervention on adolescent girls' PA, screen-time, and self-efficacy towards PA, as well as the intrinsic motivation of exergaming. Participants were 37 girls aged 14-18 years (65% African American, 35% White) who were overweight or obese (body mass index ≥ 85th percentile) and were recruited from the community via school, physicians, news media, and social media sites. Adolescents were randomly assigned to a 12-week group exergaming intervention (thirty-six 60 min sessions of group-based dance exergaming in a research laboratory using Kinect for Xbox 360) or to a no-treatment control group. Outcome variables included objectively measured PA (total) and self-reported leisure-time PA (discretionary time only) 1-week before vs . 1-week after the intervention; selected type and intensity of PA when placed in a gym setting for 30 min ("cardio free choice"); screen-time; self-efficacy towards PA; and intrinsic motivation towards exergaming. Attendance to the exergaming sessions was high (80%). Compared to the control group, the intervention group self-reported an increase in PA ( p = 0.035) and fewer hours watching TV/videos ( p = 0.01) after the intervention, but there were no significant differences in sedentary, light, moderate, or vigorous PA measured by accelerometry. The intervention group significantly improved self-efficacy towards PA ( p = 0.028). The intervention group highly rated intrinsic motivation towards exergaming. Twelve weeks

  17. Twelve Weeks of Plyometric Training Improves Motor Performance of 7- to 9-Year-Old Boys Who Were Overweight/Obese: A Randomized Controlled Intervention.

    Science.gov (United States)

    Nobre, Gabriela G; de Almeida, Marcelus B; Nobre, Isabele G; Dos Santos, Fernanda K; Brinco, Raphael A; Arruda-Lima, Thalison R; de-Vasconcelos, Kenya L; de-Lima, Jociellen G; Borba-Neto, Manoel E; Damasceno-Rodrigues, Emmanuel M; Santos-Silva, Steve M; Leandro, Carol G; Moura-Dos-Santos, Marcos A

    2017-08-01

    Nobre, GG, de Almeida, MB, Nobre, IG, dos Santos, FK, Brinco, RA, Arruda-Lima, TR, de-Vasconcelos, KL, de-Lima, JG, Borba-Neto, ME, Damasceno-Rodrigues, EM, Santos-Silva, SM, Leandro, CG, and Moura-dos-Santos, MA. Twelve weeks of plyometric training improves motor performance of 7- to 9-year-old boys who were overweight/obese: a randomized controlled intervention. J Strength Cond Res 31(8): 2091-2099, 2017-The prevalence of childhood overweight/obesity has increased, and physical training at school may to be effective to combat this scenario. We analyzed the effects of a protocol of plyometric training on body composition and motor performance of boys who were overweight/obese aged 7-9 years. The sample was randomly assigned into 2 groups: plyometric training group (T, n = 40) and control group (C, n = 19). Training consisted of 20 min·d (twice a week, during 12 weeks) of lower extremity plyometric exercise. Health-related physical fitness was measured by handgrip strength, standing long jump (SLJ), curl-ups, sit and reach, square test, running speed, and mile run test. Gross motor coordination was evaluated by means of the Körperkoordinations-test für Kinder (KTK) tests. Baseline and postintervention differences were investigated, and effect size was estimated through Cohen's d coefficient. Both groups showed increased body weight, height, and sitting height after intervention with a negligible effect size. Only T group showed increased fat-free mass (p = 0.011) compared with baseline values with small effect size. Plyometric training improved handgrip strength (d = 0.23), sit and reach (d = 0.18), curl-ups (d = 0.39), SLJ (d = 0.80), agility (d = 0.48), and time in the mile run test (d = 0.38). For gross motor coordination results, T group showed better performance in all tests after plyometric training with moderate/large effect size. Thus, 12 weeks of PT improved health-related physical fitness components and motor coordination acquisition of 7- to 9-year

  18. Knee kinematics and kinetics in former soccer players with a 16-year-old ACL injury – the effects of twelve weeks of knee-specific training

    Directory of Open Access Journals (Sweden)

    Holmström Eva

    2007-04-01

    Full Text Available Abstract Background Training of neuromuscular control has become increasingly important and plays a major role in rehabilitation of subjects with an injury to the anterior cruciate ligament (ACL. Little is known, however, of the influence of this training on knee stiffness during loading. Increased knee stiffness occurs as a loading strategy of ACL-injured subjects and is associated with increased joint contact forces. Increased or altered joint loads contribute to the development of osteoarthritis. The aim of the study was to determine if knee stiffness, defined by changes in knee kinetics and kinematics of gait, step activity and cross-over hop could be reduced through a knee-specific 12-week training programme. Methods A 3-dimensional motion analysis system (VICON and a force plate (AMTI were used to calculate knee kinetics and kinematics before and after 12 weeks of knee-specific training in 12 males recruited from a cohort with ACL injury 16 years earlier. Twelve uninjured males matched for age, sex, BMI and activity level served as a reference group. Self-reported patient-relevant data were obtained by the KOOS questionnaire. Results There were no significant changes in knee stiffness during gait and step activity after training. For the cross-over hop, increased peak knee flexion during landing (from 44 to 48 degrees, p = 0.031 and increased internal knee extensor moment (1.28 to 1.55 Nm/kg, p = 0.017 were seen after training, indicating reduced knee stiffness. The KOOS sport and recreation score improved from 70 to 77 (p = 0.005 and was significantly correlated with the changes in knee flexion during landing for the cross-over hop (r = 0.6, p = 0.039. Conclusion Knee-specific training improved lower extremity kinetics and kinematics, indicating reduced knee stiffness during demanding hop activity. Self-reported sport and recreational function correlated positively with the biomechanical changes supporting a clinical importance of the

  19. Twelve weeks of dance exergaming in overweight and obese adolescent girls: Transfer effects on physical activity, screen time, and self-efficacy

    Science.gov (United States)

    Staiano, Amanda E.; Beyl, Robbie A.; Hsia, Daniel S.; Katzmarzyk, Peter T.; Newton, Robert L.

    2016-01-01

    towards exergaming. Conclusion Twelve weeks of exergaming was associated with positive impacts on adolescent girls’ self-reported PA, television viewing, self-efficacy, and intrinsic motivation. Future research is warranted to leverage exergames as an enjoyable, motivating, and effective PA tool. PMID:28491483

  20. Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

    Science.gov (United States)

    Lee, Bok Y.; AL-Waili, Noori; Stubbs, Dean; Wendell, Keith; Butler, Glenn; AL-Waili, Thia; AL-Waili, Ali

    2010-01-01

    Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT) device (EPRT Technologies-USA, Simi Valley, CA) in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30-100%). The patients

  1. Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment.

    Directory of Open Access Journals (Sweden)

    Jenna B Gillen

    Full Text Available We investigated whether sprint interval training (SIT was a time-efficient exercise strategy to improve insulin sensitivity and other indices of cardiometabolic health to the same extent as traditional moderate-intensity continuous training (MICT. SIT involved 1 minute of intense exercise within a 10-minute time commitment, whereas MICT involved 50 minutes of continuous exercise per session.Sedentary men (27±8y; BMI = 26±6kg/m2 performed three weekly sessions of SIT (n = 9 or MICT (n = 10 for 12 weeks or served as non-training controls (n = 6. SIT involved 3x20-second 'all-out' cycle sprints (~500W interspersed with 2 minutes of cycling at 50W, whereas MICT involved 45 minutes of continuous cycling at ~70% maximal heart rate (~110W. Both protocols involved a 2-minute warm-up and 3-minute cool-down at 50W.Peak oxygen uptake increased after training by 19% in both groups (SIT: 32±7 to 38±8; MICT: 34±6 to 40±8ml/kg/min; p<0.001 for both. Insulin sensitivity index (CSI, determined by intravenous glucose tolerance tests performed before and 72 hours after training, increased similarly after SIT (4.9±2.5 to 7.5±4.7, p = 0.002 and MICT (5.0±3.3 to 6.7±5.0 x 10-4 min-1 [μU/mL]-1, p = 0.013 (p<0.05. Skeletal muscle mitochondrial content also increased similarly after SIT and MICT, as primarily reflected by the maximal activity of citrate synthase (CS; P<0.001. The corresponding changes in the control group were small for VO2peak (p = 0.99, CSI (p = 0.63 and CS (p = 0.97.Twelve weeks of brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men, despite a five-fold lower exercise volume and time commitment.

  2. Electric-dipole-coupled H2O@C60 dimer: Translation-rotation eigenstates from twelve-dimensional quantum calculations.

    Science.gov (United States)

    Felker, Peter M; Bačić, Zlatko

    2017-02-28

    We report on variational solutions to the twelve-dimensional (12D) Schrödinger equation appertaining to the translation-rotation (TR) eigenstates of H 2 O@C 60 dimer, associated with the quantized "rattling" motions of the two encapsulated H 2 O molecules. Both H 2 O and C 60 moieties are treated as rigid and the cage-cage geometry is taken to be fixed. We consider the TR eigenstates of H 2 O@C 60 monomers in the dimer to be coupled by the electric dipole-dipole interaction between water moieties and develop expressions for computing the matrix elements of that interaction in a dimer basis composed of products of monomer 6D TR eigenstates reported by us recently [P. M. Felker and Z. Bačić, J. Chem. Phys. 144, 201101 (2016)]. We use these expressions to compute TR Hamiltonian matrices of H 2 O@C 60 dimer for two values of the water dipole moment and for various dimer geometries. 12D TR eigenstates of the dimer are then obtained by filter diagonalization. The results reveal two classes of eigenstates, distinguished by the leading order (first or second) at which dipole-dipole coupling contributes to them. The two types of eigenstates differ in the general magnitude of their dipole-induced energy shifts and in the dependence of those shifts on the value of the water dipole moment and on the distance between the H 2 O@C 60 monomers. The dimer results are also found to be markedly insensitive to any change in the orientations of the C 60 cages. Finally, the results lend some support for the interpretation that electric dipole-dipole coupling is at least partially responsible for the apparent reduced-symmetry environment experienced by H 2 O in the powder samples of H 2 O@C 60 [K. S. K. Goh et al., Phys. Chem. Chem. Phys. 16, 21330 (2014)], but only if the water dipole is taken to have a magnitude close to that of free water. The methodology developed in the paper is transferable directly to the calculation of TR eigenstates of larger H 2 O@C 60 assemblies, that will

  3. Variedades de batatinha (Solanum tuberosum L.. I - Comportamento de 12 variedades procedentes da Holanda, Alemanha e Suécia Behavior of twelve potato varieties from European sources

    Directory of Open Access Journals (Sweden)

    O. J. Boock

    1956-01-01

    Full Text Available No presente trabalho são relatadas experiências com 12 variedades de batatinha (Solanum tuberosum L., recebidas da Holanda (Prinslander, Irene, Froma e Barima, Alemanha (Merkur, Sabina, Linda e Concordia e Suécia Konsuragis, Eigenheimer, Voran e Jätte-Bintje. Essas experiências, em número de seis, das quais três no chamado período "da sêca" (março-julho e três no "das águas" (setembro-janeiro, foram executadas nas localidades de Campinas, Louveira o Capão Bonito, no Estado de São Paulo. Ficou evidenciado o seguinte: a dado o bom estado de brotação dos tubérculos, as porcentagens de falhas no plantio "da sêca" foram baixas; já no plantio "das águas", as variedades de brotação lenta, como "Voran" e "Sabina", falharam muito; b "Prinslander" e "Konsuragis" resistiram bem à sêca prolongada, e "Barima" o "Linda" mostraram ser muito sensíveis; c "Linda", "Voran" e "Merkur", principalmente a primeira destas, apresentaram boa resistência a Phytophthora infestans, e "Jätte-Bintje" foi muito suscetível; "Voran", "Irene", "Prinslander" e "Barima" não ofereceram resistência a Alternaria solani; d "Merkur" e "Konsuragis" foram as mais produtivas para as duas épocas de plantio, sendo que "nas águas", "Eigenheimer", "Barima", "Concordia" e Jätte-Bintje", também produziram bem. Outros aspectos relacionados com variedades foram estudados.Twelve potato varieties imported from Holland (Prinslander, Irene, Froma, and Barima, Germany (Merkur, Sabina, Linda, and Concordia, and Sweden (Konsuragis, Eigenheimer, Voran, and Jätte-Bintje were compared in six experiments carried out at three different localities in the state of São Paulo (Campinas, Louveira, and Capão Bonito. The experiments were planted twice a year, once during the so-called dry season (March lo July, and another time during the rainy season (September to March. The following results were obtained: a plantings made in the dry season had a good stand, whereas this was

  4. Energy, a networked Europe. Twelve proposals for a common energy infrastructure policy. Report addressed to Francois Hollande, President of the French Republic

    International Nuclear Information System (INIS)

    Derdevet, Michel

    2015-01-01

    the networks is a necessity if the Europeans want the energy transition to be a success. Article 194 of the Treaty of Lisbon has already laid down the way to greater intervention by the Union in this regard. But the Europeans must go further and explore, as quickly as possible, areas of joint cooperation, innovation and investment. The challenge is great since hundreds of billions of euros of investment will have to be made between now and 2030, and no argument is needed to convince oneself that, in a convalescent Europe, every euro will have to be invested with the greatest concern for effectiveness for our communities. Finally, this 'networked European energy', that we all wish for, will not only be a physical, technical and economic challenge. It must also embody these 'shared idiosyncrasies' that today characterise the European energy space: the verticality of the national hierarchies will be followed by the horizontality of communication between the territories; the authority of the powers in place, by the legitimacy of the citizen, initiative and success; industrial uniformity, by the diversity of models of organisation; a situation of separate States, by exchanges within the European area. The twelve proposals presented at the end of this report thus aim to promote the emergence of a coherent and pragmatic European approach in the field of networks, to solve today's problems and to meet tomorrow's challenges. From this standpoint, these proposals are structured around three main focus areas: - Revising security of supply and cooperation between the network companies, but also the local authorities involved in the energy transition, - Strengthening coordination of the regulations and the funding levers to optimise the infrastructure costs, while investing in the territories crossed by this strategic infrastructure, - Promoting Europe as an energy innovation leader, giving a new impetus and a new dimension to its R and D, in

  5. Twelve tips for facilitating Millennials' learning.

    Science.gov (United States)

    Roberts, David H; Newman, Lori R; Schwartzstein, Richard M

    2012-01-01

    The current, so-called "Millennial" generation of learners is frequently characterized as having deep understanding of, and appreciation for, technology and social connectedness. This generation of learners has also been molded by a unique set of cultural influences that are essential for medical educators to consider in all aspects of their teaching, including curriculum design, student assessment, and interactions between faculty and learners.  The following tips outline an approach to facilitating learning of our current generation of medical trainees.  The method is based on the available literature and the authors' experiences with Millennial Learners in medical training.  The 12 tips provide detailed approaches and specific strategies for understanding and engaging Millennial Learners and enhancing their learning.  With an increased understanding of the characteristics of the current generation of medical trainees, faculty will be better able to facilitate learning and optimize interactions with Millennial Learners.

  6. Twelve Steps toward Revitalization for Teachers.

    Science.gov (United States)

    Newbrough, Art

    1983-01-01

    A dozen common sense ways to respond to and counter the teacher burnout syndrome are briefly discussed. Strategies include physical exercise, stress controls, recultivating special relationships, self-expressions, celebrations, enthusiasm maintenance, and professional support. The aticle is designed to help educators maintain a perspective on…

  7. Twelve Middle-School Teachers' Planning.

    Science.gov (United States)

    Brown, Deborah Sardo

    1988-01-01

    Case studies described 12 middle-school teachers' instructional yearly, unit, weekly, and daily planning on the basis of a background questionnaire, interview protocols, an analysis of written plans, think-aloud typescripts, and a questionnaire. A process model best characterized teachers long-term planning, while an agenda-formulation model fit…

  8. Twelve years of Neandertal genetic discoveries

    DEFF Research Database (Denmark)

    Orlando, Ludovic Antoine Alexandre; Hänni, Catherine

    2011-01-01

    The first mitochondrial DNA sequence from a Neandertal specimen was recovered in 1997. Now the completion of the whole Neandertal genome has been announced to be completed in the forthcoming months. About one ­million nucleotides of nuclear DNA have already been sequenced and so far 15 Neandertal...

  9. Splenic tuberculosis. Report of twelve cases

    International Nuclear Information System (INIS)

    Adil, A.; Chikhaoui, N.; Ousehal, A.; Kadiri, R.

    1995-01-01

    Tuberculosis of the spleen is not exceptional. The authors report ten cases which occurred with a predominance in young male adults. All patients had at least one other site of tuberculosis without any HIV infection. All patients had focal splenic lesions in the form of scattered hypo-echogenic and hypodense nodules. These nodules had a pseudo-tumor appearance in one case. CT-guided puncture was performed in one case. Splenic tuberculosis is not as rare as is sometimes thought. The CT-guided splenic puncture is now performed routinely and remains the ideal diagnostic approach. (authors). 9 refs., 5 figs

  10. Digitally controlled twelve-pulse firing generator

    International Nuclear Information System (INIS)

    Berde, D.; Ferrara, A.A.

    1981-01-01

    Control System Studies for the Tokamak Fusion Test Reactor (TFTR) indicate that accurate thyristor firing in the AC-to-DC conversion system is required in order to achieve good regulation of the various field currents. Rapid update and exact firing angle control are required to avoid instabilities, large eddy currents, or parasitic oscillations. The Prototype Firing Generator was designed to satisfy these requirements. To achieve the required /plus or minus/0.77/degree/firing accuracy, a three-phase-locked loop reference was designed; otherwise, the Firing Generator employs digital circuitry. The unit, housed in a standard CAMAC crate, operates under microcomputer control. Functions are performed under program control, which resides in nonvolatile read-only memory. Communication with CICADA control system is provided via an 11-bit parallel interface

  11. Twelve tips for "flipping" the classroom.

    Science.gov (United States)

    Moffett, Jennifer

    2015-04-01

    The flipped classroom is a pedagogical model in which the typical lecture and homework elements of a course are reversed. The following tips outline the steps involved in making a successful transition to a flipped classroom approach. The tips are based on the available literature alongside the author's experience of using the approach in a medical education setting. Flipping a classroom has a number of potential benefits, for example increased educator-student interaction, but must be planned and implemented carefully to support effective learning.

  12. Twelve steps to evaluating interprofessional education

    Directory of Open Access Journals (Sweden)

    Scott Reeves, PhD

    2016-12-01

    Full Text Available تضع هذه الورقة خطة؛ خطوة بخطوة لمساعدة القراء على تصميم وتطبيق وتوزيع تقاييم التعليم المتداخل بين التخصصات نقدم الإثنتي عشرة خطوة التالية التي تعتبر أساسية لهذه العملية: صياغة أسئلة التقييم, والاتفاق على نهج التقييم, واستخدام أطر للتقييم, والاعتماد على خبرات التقييم, ومراجعة الأدبيات, واختيار الأسلوب والتصميم, وتأمين الموافقة الأخلاقية, والوصول إلى البيانات, ومعالجة قضايا العمل الميداني, واستخدام أدوات التقييم, والنظر في الموارد, وخيارات التوزيع.

  13. Part Twelve. The Voyages of John Matthias

    OpenAIRE

    Printz-Påhlson, Göran

    2013-01-01

    In August 1974, when the Watergate scandal was moving into its last phase, the American poet John Matthias returned to his home, in South Bend, Indiana, after a year’s stay in England, traveling on the Polish ocean-liner Stefan Bathory. In June of 1976 he set out to sea again, this time on a Russian ship, the Mikhail Lermontov, in order to spend another year in England, as a Visiting Fellow in Poetry in Clare Hall, Cambridge. The voyages took approximately nine days each, and on both ships he...

  14. Effectiveness of the Twelve-Hour Shift.

    Science.gov (United States)

    Brinton, Robert D.

    1983-01-01

    Although labor unions traditionally have fought for shorter working hours, there have been recent reversals in this trend. The Pulp and Paperboard Division of Temple-Eastex Incorporated converted to a 12-hour shift and found that safety improved, productivity increased, and overtime decreased. (JOW)

  15. Twelve tips for implementing effective service learning.

    Science.gov (United States)

    Playford, Denese; Bailey, Susan; Fisher, Colleen; Stasinska, Ania; Marshall, Lewis; Gawlinski, Michele; Young, Susan

    2017-11-24

    Service learning is an educational methodology that facilitates transformation of students' knowledge, attitudes and attitudes around holistic care through work with community organizations. To implement academically, defensible service learning requires faculty endorsement, consideration of course credit, an enthusiastic champion able to negotiate agreements with organizations, organizations' identification of their own projects so they are willing to both fund and supervise them, curricular underpinning that imparts the project skills necessary for success, embedding at a time when students' clinical identity is being formed, small packets of curriculum elements delivered "just in time" as students engage with their project, flexible online platform/s, assessment that is organically related to the project, providing cross cultural up-skilling, and focused on the students' responsibility for their own product. The result is a learning experience that is engaging for medical students, links the university to the community, and encourages altruism which is otherwise reported to decline through medical school.

  16. Twelve Action Lines For a Better World

    Directory of Open Access Journals (Sweden)

    F. J. Radermacher

    2016-05-01

    Full Text Available This article describes a global governance system that—from the author’s point of view—would lead to sustainability and allow the implementation of the Sustainable Development Goals (SDGs, which have just been adopted at the UN level. Major elements are (1 the integration of existing international regimes in the area of the UN, WTO and the world financial system into an integrated “Global Governance Body”. (2 This institution would, among other functions, be responsible for the major global commons and put a fee on their usage with two aims: (i to protect them and (ii to generate money for financing global development and the SDGs. (3 To monitor the income and property distribution by politics with the political mandate, to keep it in the so-called “efficient inequality range”. This may need international co-financing. (4 It will, if done properly, prevent two-class societies, it will furthermore allow the building-up of social systems everywhere in the world with the aim to have a reasonable balance of wealth in all states, and also between states. (5 It will also be of help if artificial intelligence systems took over hundreds of millions of jobs for highly qualified people in the next decade. (6 This global institution would also be able to pay in defense of cultural diversity and for the protection of the environment, e.g. rainforests. (7 This would also allow us to do what is needed for avoiding uncontrolled climate change, e.g. improve the recent Paris accord concerning climate.

  17. Twelve Tips for Effective Electronic Presentation.

    Science.gov (United States)

    Crosby, Joy

    1994-01-01

    Offers 12 tips for effective electronic presentation. This article is intended for readers who may be considering using electronic presentation for the first time. Offers reasons for its popularity and occasions when it may be used. The tips offer assistance in the design and presentation of electronic material. (LZ)

  18. Isolation and characterization of twelve polymorphic microsatellite ...

    Indian Academy of Sciences (India)

    1Departamento de Agronomia, and 2Departamento de Biologia Geral, Centro de Ciências Biológicas, Universidade ... genetic structure, conservation biology and for understand- ... Rio Grande do Sul and south of Santa Catarina states, occur-.

  19. Twelve clinically significant points in medulloblastoma

    International Nuclear Information System (INIS)

    Sugiyama, Kazuhiko; Yamasaki, Fumiyuki; Kajiwara, Yoshinori; Watanabe, Yosuke; Takayasu, Takeshi; Kurisu, Kaoru

    2011-01-01

    Though medulloblastoma is the most common malignant brain tumor during childhood, only 80 newly-diagnosed tumors develos every year, as the annual incidence is extremely rare with an occurrence of 0.5 per 100,000 children younger than 15-year-old and of 0.7 per 100,000 for the entire population. Images obtained of medulloblastoma are characterized by a round heterogeously-enhanced mass in or adjacent to the VIth ventricle. Objectives of surgical treatment are the maximum resectioning of the main mass and the relief of the obstructive hydrocephalus. Cerebellar mutism occurs a few days after one fourth of medulloblastoma surgery, and lasts approximately for 50 days followed by subsequent dysarthria. Pathological subtypes include classic medulloblastoma, desmoplastic/nodular medulloblastoma, medulloblastoma with extensive nodularity, large cell/anaplastic medulloblastoma, all corresponding to World Health Organization (WHO) grade IV. According to age, residual tumor size, and disseminated staging, patients are divided into average-risk group, high-risk group, or baby-medulloblastoma after surgery. Standard treatment in average-risk group includes 23.4-Gy cranio-spinal irradiation (CSI) with posterior boost followed by chemotherapy consisting of cisplatin (CDDP), alkylating agents, and vincristine. Patients in high-risk group receive over 36-Gy CSI with boost radiotherapy to nodular lesions before, concomitantly with, or followed by dose-intensity chemotherapy. In cases with gross total removal, or desmoplastic/nodular pathology radiotherapy for patients younger than 3-year-old are often delayed until they turn 3-year-old, and are able to survive for long time by appropriate chemotherapy alone. Adolescent survivors with childhood medulloblastoma have a number of late adverse effects regarding another neoplasm, neuro-cognitive function, endocrine activity, cardiovascular organs, and skeletal system. Comprehensive follow-up and support system are mandatory. (author)

  20. A fabric phase sorptive extraction-High performance liquid chromatography-Photo diode array detection method for the determination of twelve azole antimicrobial drug residues in human plasma and urine.

    Science.gov (United States)

    Locatelli, Marcello; Kabir, Abuzar; Innosa, Denise; Lopatriello, Teresa; Furton, Kenneth G

    2017-01-01

    This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) method for the simultaneous extraction and analysis of twelve azole antimicrobial drug residues that include ketoconazole, terconazole, voriconazole, bifonazole, clotrimazole, tioconazole, econazole, butoconazole, miconazole, posaconazole, ravuconazole, and itraconazole in human plasma and urine samples. The selected azole antimicrobial drugs were well resolved by using a Luna C 18 column (250mm×4.6mm; 5μm particle size) in gradient elution mode within 36min. The analytical method was calibrated and validated in the range from 0.1 to 8μg/mL for all the drug compounds. Blank human plasma and urine were used as the sample matrix for the analysis; while benzyl-4-hydroxybenzoate was used as the internal standard (IS). The limit of quantification of the FPSE-HPLC-PDA method was found as 0.1μg/mL and the weighted-matrix matched standard calibration curves of the drugs showed a good linearity upto a concentration of 8μg/mL. The parallelism tests were also performed to evaluate whether overrange sample can be analyzed after dilution, without compromising the analytical performances of the validated method. The intra- and inter-day precision (RSD%) values were found ≤13.1% and ≤13.9%, respectively. The intra- and inter-day trueness (bias%) values were found in the range from -12.1% to 10.5%. The performances of the validated FPSE-HPLC-PDA were further tested on real samples collected from healthy volunteers after a single dose administration of itraconazole and miconazole. To the best of our knowledge, this is the first FPSE extraction procedure applied on plasma and urine samples for the simultaneous determination of twelve azole drugs possessing a wide range of logK ow values (extending from 0.4 for fluconazole to 6.70 of butoconazole) and could be adopted as a rapid and robust green analytical tool for clinical and

  1. Gender differences in sport injury risk and types of inju-ries: a retrospective twelve-month study on cross-country skiers, swimmers, long-distance runners and soccer players.

    Science.gov (United States)

    Ristolainen, Leena; Heinonen, Ari; Waller, Benjamin; Kujala, Urho M; Kettunen, Jyrki A

    2009-01-01

    This twelve months survey compared injury risk and injury types by genders (312 females, 262 males) in 15- to 35-year-old cross-country skiers, swimmers, long- distance runners and soccer players. More male than female athletes reported at least one acute injury (44% vs. 35%, p gender differences in either of these comparisons. After adjustment for sport event males were at increased risk for posterior thigh overuse injuries compared to females (relative risk (RR) 5.8, 95% confidence interval (CI) 1.3 to 26.4, p difference between the sexes in overuse injury to the ankle persisted (female 0.11 vs. male 0.02 injuries/1000 exposure hours, p difference was found in such injuries when calculated per 1000 exposure hours. In conclusion, we found some gender differences in sport-related injuries, but most of these differences seemed to be explained at least in part by differences in the amount of training. Key pointsOnly a few sport injury studies have compared in-jury rates between the sexesOverall gender-related risk for acute and overuse injuries in top-level athletes between the sexes was smallSome gender differences in the specific anatomical locations of injuries as well as in specific injuries in sports were foundSome of these differences seem to be explained by the differences in the amount of training.

  2. Survey on the use of psychotropic drugs by twelve military police units in the municipalities of Goiânia and Aparecida de Goiânia, state of Goiás, Brazil.

    Science.gov (United States)

    Costa, Sérgio Henrique Nascente; Cunha, Luiz Carlos da; Yonamine, Maurício; Pucci, Liuba Laxor; Oliveira, Fernando Gomes Ferreira; Souza, Camila Gabriela de; Mesquita, Guilherme Alves; Vieira, Ana Paula de Toledo; Vinhal, Ludmilla Barros; Dalastra, Janayna; Leles, Cláudio Rodrigues

    2010-12-01

    To determine the prevalence of psychotropic drug use among military police officers in the state of Goiás, Brazil. Study carried out at twelve military police units located in the municipalities of Goiânia and Aparecida de Goiânia between March to October 2008. Volunteers (n=221) were interviewed about drug use using a questionnaire especially designed by the Centro Brasileiro de Informações sobre Drogas Psicotrópicas (CEBRID). Descriptive statistics was used to determine the prevalence of licit and illicit drug use in the study sample. The frequency of use was divided into: 1) lifetime use: tobacco-39.9%, alcohol-87.8%, cannabis-8.1%, cocaine-1.8%, stimulants-7.2%, solvents-10.0%, sedatives, anxiolytics, antidepressants-6.8%, LSD-0.5%, Bentyl®-0.5%, anabolic steroids-5.4%; 2) use in the previous year: tobacco-15.4%, alcohol-72.9%, stimulants-6.3%, solvents-0.5%, sedatives, anxiolytics, antidepressants-3.7%; 3) use in the previous 30 days: tobacco-14.5%, alcohol-57.5%, stimulants-5.0%, solvents-0.5, sedatives, anxiolytics, antidepressants-3.7%. The high prevalence rate of psychotropic drug use found amoung military police officers in two cities of the state of Goiás in Brazil can be considered an important factor with potential influence on job activities.

  3. Proper Names and Their Functions in the Text Coherency Formation (at the Material of the Novels “The Twelve Chairs” and “The Little Golden Calf” by I. Ilf and E. Petrov

    Directory of Open Access Journals (Sweden)

    Tatyana Valentinovna Milevskaya

    2015-12-01

    Full Text Available The article deals with the onomastic space structure in the literary text and its constituents functions in realization of coherency as a text forming category. It is stated that providing global text coherence onyms could represent both denotative coreference and significative coherence of nomination units. The data of the studies have proved that the following units take part in providing text coherency of the novel "The Twelve Chairs" by I. Ilf and E. Petrov: anthroponyms, toponyms, and ergonyms. Having used a frame approach to the proper names analysis the authors could modify and clearly specify a detailed onym functional classification (which is known in linguistics of onyms, pointing to the necessary to distinguish six instead of three groups of onyms according to their functions in providing text coherency: 1 onyms that maintain coherency of the whole text; 2onyms that construct space-time coordinates of the literary picture of the world; 3 onyms that are both naming the characters who directly interact with the protagonists and designing external relations of the text passage; 4 onyms that organize internal relations of the text passage and represent the main characters of the text passage; 5 onyms that form space-time background of the text passage; 6 optional onyms, which do not play a significant role in the text coherency. With the particular examples the authors proved that some onyms could simultaneously perform different functions forming both external and internal links.

  4. MODELOS SOCIALES DE ALUMNOS DE DOCE AÑOS DE LA ESCUELA PRIMARIA DE LA EDUCACIÓN PÚBLICA EN GRECIA SOCIAL MODELS OF TWELVE YEARS OLD STUDENTS OF THE PUBLIC PRIMARY SCHOOL IN GREECE

    Directory of Open Access Journals (Sweden)

    Vassilis Karnavas

    2011-10-01

    Full Text Available La multifacética crisis social que está sufriendo Grecia durante los últimos años, se imprenta, según nuestra opinión, en la manera que los alumnos de doce años optan por sus modelos sociales. La siguiente investigación se enmarca en el ámbito de la temprana socialización política. De los datos que se han coleccionado, se hace evidente que los alumnos griegos en esta edad recogen sus modelos sociales, principalmente, del mundo del espectáculo, mientras áreas como la política y la ciencia se encuentran en nivel bajo entre sus preferencias.The, mainly political, multiplex crisis which Greece is going through during the last years, is also reflects, to our opinion, on the way the twelve year old students choose their social models. The following research is included in the area of Early Political Socialization. The research concludes that Greek students of that age choose their social models mainly from the entertainment industry, while politics and science are in a very low level among their preferences.

  5. Determination of twelve herbicides in tobacco by a combination of solid–liquid–solid dispersive extraction using multi-walled carbon nanotubes, dispersive liquid-liquid micro-extraction, and detection by GC with triple quadrupole mass spectrometry

    International Nuclear Information System (INIS)

    Liao, Qie Gen; Zhou, Yao Min; Luo, Lin Guang; Wang, Li Bing; Feng, Xiao Hu

    2014-01-01

    We report on a method for the determination of twelve herbicides using solid–liquid–solid dispersive extraction (SLSDE), followed by dispersive liquid-liquid micro-extraction (DLLME) and quantitation by gas chromatography with triple quadrupole mass spectrometric detection. SLSDE was applied to the extraction of herbicides from tobacco samples using multi-walled carbon nanotubes (MWCNTs) as clean-up adsorbents. The effect of the quantity of MWCNTs on SLSDE, and of type and volume of extraction and disperser solvents and of salt effect on DLLME were optimized. Good linearity is obtained in the 5.0 - 500 μg kg −1 concentration range, with regression coefficients of >0.99. Intra-day and inter-day repeatability, expressed as relative standard deviations, are between 3 and 9 %. The recoveries in case of herbicide-spiked tobacco at concentration levels of 20.0, 50.0 and 100.0 g kg −1 ranged from 79 to 105 %, and LODs are between 1.5 and 6.1 μg kg −1 . All the tobacco samples were found to contain butralin and pendimethalin at levels ranging from 15.8 to 500.0 μg kg −1 . (author)

  6. Ultrasonographic findings of uterine leiomyosarcoma: Differentiation from leiomyoma

    Energy Technology Data Exchange (ETDEWEB)

    Song, Mi Jin; Kim, Jeong Ah [Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2003-12-15

    To analyze the ultrasonographic findings of uterine leiomyosarcoma and to differentiate them from leiomyoma. From January 1998 to December 2001, a retrospective review of ultrasonographic findings of 7 patients with pathologically proven uterine leiomyosarcoma and 30 patients with leiomyoma was done. The mean size of leiomyosarcoma was 72 X 59 X 74 mm while the echogenicity, mixed. The shape of masses was round in five cases and ovoid in two. The margins of the mass were well-defined in five cases and partially indistinct in two. The locations of the mass were intramural in four cases, submucosal in two cases and indetermined in one case. The masses abutted the endometrium in four cases while invasion into the endometrium was seen in three. All masses were single. On the other hand, the mean size of leiomyoma was 52 X 45 X 49 mm. The echogenicities were homogenously hypoechoic in eighteen cases and mixed in twelve. The shape of masses was round in nineteen cases and ovoid in eleven cases. The margins of the mass were well-defined in twenty nine cases and partially indistinct in one case. The locations of the mass were intramural in twenty five cases, subserosal in four cases, and indetermined in one case. Separation between the masses and endometrium was definite in twenty two cases while the masses abutted the endometrium in seven cases. The invasion of the masses into the endometrium was noted in one case. Twenty five cases showed multiple masses while the remaining five cases were single mass. The possibility of leiomyosarcoma should be taken in to consideration when there is a single uterine mass larger than 7 cm that abutted the endometrium.

  7. Ultrasonographic findings of uterine leiomyosarcoma: Differentiation from leiomyoma

    International Nuclear Information System (INIS)

    Song, Mi Jin; Kim, Jeong Ah

    2003-01-01

    To analyze the ultrasonographic findings of uterine leiomyosarcoma and to differentiate them from leiomyoma. From January 1998 to December 2001, a retrospective review of ultrasonographic findings of 7 patients with pathologically proven uterine leiomyosarcoma and 30 patients with leiomyoma was done. The mean size of leiomyosarcoma was 72 X 59 X 74 mm while the echogenicity, mixed. The shape of masses was round in five cases and ovoid in two. The margins of the mass were well-defined in five cases and partially indistinct in two. The locations of the mass were intramural in four cases, submucosal in two cases and indetermined in one case. The masses abutted the endometrium in four cases while invasion into the endometrium was seen in three. All masses were single. On the other hand, the mean size of leiomyoma was 52 X 45 X 49 mm. The echogenicities were homogenously hypoechoic in eighteen cases and mixed in twelve. The shape of masses was round in nineteen cases and ovoid in eleven cases. The margins of the mass were well-defined in twenty nine cases and partially indistinct in one case. The locations of the mass were intramural in twenty five cases, subserosal in four cases, and indetermined in one case. Separation between the masses and endometrium was definite in twenty two cases while the masses abutted the endometrium in seven cases. The invasion of the masses into the endometrium was noted in one case. Twenty five cases showed multiple masses while the remaining five cases were single mass. The possibility of leiomyosarcoma should be taken in to consideration when there is a single uterine mass larger than 7 cm that abutted the endometrium.

  8. Glycaemic index and glycaemic load of selected popular foods consumed in Southeast Asia.

    Science.gov (United States)

    Sun, Lijuan; Lee, Davina Elizabeth Mei; Tan, Wei Jie Kevin; Ranawana, Dinesh Viren; Quek, Yu Chin Rina; Goh, Hui Jen; Henry, Christiani Jeyakumar

    2015-03-14

    The objective of the present study was to determine the glycaemic index (GI) and glycaemic load (GL) values of standard portion sizes of Southeast Asian traditional foods. A total of fifteen popular Southeast Asian foods were evaluated. Of these foods, three were soft drinks, while the other twelve were solid foods commonly consumed in this region. In total, forty-seven healthy participants (eighteen males and twenty-nine females) volunteered to consume either glucose at least twice or one of the fifteen test foods after a 10-12 h overnight fast. Blood glucose concentrations were analysed before consumption of the test food, and 15, 30, 45, 60, 90 and 120 min after food consumption, using capillary blood samples. The GI value of each test food was calculated by expressing the incremental area under the blood glucose response curve (IAUC) value of the test food as a percentage of each participant's average IAUC value, with glucose as the reference food. Among the fifteen foods tested, six belonged to low-GI foods (Ice Green Tea, Beehoon, Pandan Waffle, Curry Puff, Youtiao and Kaya Butter Toast), three belonged to medium-GI foods (Barley Drink, Char Siew Pau and Nasi Lemak), and the other six belonged to high-GI foods (Ice Lemon Tea, Chinese Carrot Cake, Chinese Yam Cake, Chee Cheong Fun, Lo Mai Gai and Pink Rice Cake). The GI and GL values of these traditional foods provide valuable information to consumers, researchers and dietitians on the optimal food choice for glycaemic control. Moreover, our dataset provides GI values of fifteen foods that were not previously tested extensively, and it presents values of foods commonly consumed in Southeast Asia.

  9. Avaliação isocinética de 18 pacientes do sexo masculino submetidos à correção cirúrgica da luxação acromioclavicular aguda com seguimento mínimo de dois anos Isokinetic evaluation of eighteen male patients submitted to surgical corretion of acute acromioclavicular luxation with a minimum two-year follow-up

    Directory of Open Access Journals (Sweden)

    Flavio Almeida Salles

    2002-06-01

    Full Text Available Foram estudados 18 pacientes submetidos ao tratamento cirúrgico de luxação acromioclavicular aguda do grau III da classificação de ALLMAN-TOSSY, todos do sexo masculino com idade média de 36 anos, foram avaliados sob o ponto de vista isocinético com tempo de evolução variando de 24 até 127 meses. A avaliação isocinética foi realizada através de um dinamômetro computadorizado marca CYBEX® modelo 6000 na velocidade angular de 60º/segundo e demonstrou resultados significantes no movimento de abdução no plano neutro, com déficit no pico de torque do lado operado, quando comparado com o lado contra-lateral. Quando comparados os ombros com e sem subluxação, os com subluxação demonstraram défcit no trabalho total tanto na adução quanto na abdução no plano neutro.Eighteen male patients, mean age 36 years, submitted to surgical treatment of ALLMAN-TOSSY grade III acute acromioclavicular luxation were studied. They were isokinetically evaluated during an evolution period ranging from 24 to 127 months. The isokinetic evaluation was carried out with a Cybex® 6000 computerized dynamometer, at a 60º/s angular speed, showing significant results in vertical abduction, with a deficit in peak torque in the operated on shoulder as compared to the contralateral side. When the groups with and without subluxation were compared a deficit in total work was observed in the group with subluxation both in adduction and abduction.

  10. Determination of polydimethylsiloxane–water partition coefficients for ten 1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene-related compounds and twelve polychlorinated biphenyls using gas chromatography/mass spectrometry

    Science.gov (United States)

    Eganhouse, Robert P.

    2016-01-01

    Polymer-water partition coefficients (Kpw) of ten DDT-related compounds were determined in pure water at 25 °C using commercial polydimethylsiloxane-coated optical fiber. Analyte concentrations were measured by thermal desorption-gas chromatography/full scan mass spectrometry (TD–GC/MSFS; fibers) and liquid injection-gas chromatography/selected ion monitoring mass spectrometry (LI–GC/MSSIM; water). Equilibrium was approached from two directions (fiber uptake and depletion) as a means of assessing data concordance. Measured compound-specific log Kpw values ranged from 4.8 to 6.1 with an average difference in log Kpw between the two approaches of 0.05 log units (∼12% of Kpw). Comparison of the experimentally-determined log Kpw values with previously published data confirmed the consistency of the results and the reliability of the method. A second experiment was conducted with the same ten DDT-related compounds and twelve selected PCB (polychlorinated biphenyl) congeners under conditions characteristic of a coastal marine field site (viz., seawater, 11 °C) that is currently under investigation for DDT and PCB contamination. Equilibration at lower temperature and higher ionic strength resulted in an increase in log Kpw for the DDT-related compounds of 0.28–0.49 log units (61–101% of Kpw), depending on the analyte. The increase in Kpw would have the effect of reducing by approximately half the calculated freely dissolved pore-water concentrations (Cfree). This demonstrates the importance of determining partition coefficients under conditions as they exist in the field.

  11. Preferencia de vacunos por el follaje de doce especies con potencial para sistemas agrosilvopastoriles en el Estado Trujillo, Venezuela Preference of cattle for the foliage of twelve species with potential for agrosilvopastoral systems in the Trujillo State, Venezuela

    Directory of Open Access Journals (Sweden)

    D.E García

    2008-09-01

    Full Text Available Con el objetivo de conocer la preferencia de bovinos jóvenes por doce especies forrajeras en el Estado Trujillo, Venezuela (Chlorophora tinctoria, Morus alba, Pithecellobium pedicellare, Gliricidia sepium, Guazuma ulmifolia, Cordia alba, Trichantera gigantea, Tithonia diversifolia, Leucaena leucocephala, Moringa oleifera, Azadirachta indica y Samanea saman se efectuó una prueba de cafetería a través de mediciones del consumo de follaje, mediante un diseño cuadrado latino con período de evaluación de 12 días. A los forrajes se les determinó la composición fitoquímica (PB, EB, FDN, fenoles, taninos condensados, taninos que precipitan proteínas y esteroles totales y la degradabilidad ruminal in situ (DMS y DMO. Las especies más preferidas fueron: P. pedicellare (327,98 g MS, L. leucocephala (325,63 g MS, M. alba (293,37 g MS, G. ulmifolia (292,48 g MS, C. tinctoria (277,18 g MS y C. alba (274,49 g MS. Los follajes de G. sepium (108,05 g MS, T. diversifolia (106,09 g MS, M. oleifera (76,28 g MS, A. indica (76,19 g MS y S. saman (58,72 g MS fueron medianamente consumidos. Sin embargo, la biomasa de T. gigantea (1,39 g MS fue prácticamente rechazada. Durante el período experimental se observaron diferentes tendencias en el consumo de cada espe­cie. No obstante, no se observó una relación significativa entre el consumo y la composición química, la concentración de metabolitos secundarios y la degradabilidad ruminal. Se concluye que es importante realizar ensayos de preferencia con animales para la selección de especies con potencial para sistemas silvopastoriles.With the objective of knowing the preference of young cattle for twelve forage species of the Trujillo State, Venezuela (Chlorophora tinctoria, Morus alba, Pithecellobium pedicellare, Gliricidia sepium, Guazuma ulmifolia, Cordia alba, Trichantera gigantea, Tithonia diversifolia, Leucaena leucocephala, Moringa oleifera, Azadirachta indica and Samanea saman a cafeteria test

  12. Physiological quality of vegetable soybean seeds produced with different fertilization and storage for twelve months = Potencial fisiológico de sementes de soja-hortaliça produzidas com diferentes adubações e armazenadas por doze meses

    Directory of Open Access Journals (Sweden)

    Juliana Maria Espíndola Lima

    2013-04-01

    Full Text Available Abstract - The vegetable soybean (Glycine max (L. Merrill has characteristics that permit utilization in food as a vegetablewhen the seeds are still immature (stage R6 and occupy 80-90% of the cavity filling the pod. The objective of this study was to evaluate the physiological potential of seeds of two vegetable soybean genotypes produced with different fertilization and stored for 12 months. In seed production field was used in the experimental design of randomized blocks with 5x2 factorial, five fertilization (conventional, intermediate, alternative, manipueira and rice hulls and two periods of evaluation (at 12 months of storage. Evaluations conducted under laboratory conditions included mass of a hundred seeds, vigor and physiological quality considering germination, germination first count, electrical conductivity, potassium leaching, sand emergence and emergence rate of seedlings. The seeds of both vegetable soybean genotype were stored in polyethylene terephthalate bottles for 12 months, as to assess physical and physiological quality under storage. Seeds of BR9452273 produced with carbonized ricehusk showed better quality at harvest and presented greater reduced of vigour after 12 months of storage. BRS 258 cultivar conventional fertilization showed seeds of less physiological quality and higher reduced the vigour after 12 months of storage. The two vegetable soybean cultivars have quality reduced during storage of seed of twelve months in bottles of polyethylene terephthalate. = Resumo – A soja-hortaliça (Glycine max (L. Merrill apresenta características que permitem utilização na alimentação humana como hortaliça, quando as sementes estão ainda imaturas (estádio R6 e ocupam 80 a 90% do preenchimento da cavidade da vagem. Objetivou-se com este trabalho avaliar o potencial fisiológico das sementes de dois genótipos de soja-hortaliça produzidas com diferentes adubações e armazenadas por 12 meses. O delineamento

  13. THE NATURE OF STARBURSTS. I. THE STAR FORMATION HISTORIES OF EIGHTEEN NEARBY STARBURST DWARF GALAXIES

    International Nuclear Information System (INIS)

    McQuinn, Kristen B. W.; Skillman, Evan D.; Stark, David; Weisz, Daniel; Cannon, John M.; Dalcanton, Julianne; Williams, Benjamin; Dolphin, Andrew; Hidalgo-RodrIguez, Sebastian; Holtzman, Jon

    2010-01-01

    We use archival Hubble Space Telescope observations of resolved stellar populations to derive the star formation histories (SFHs) of 18 nearby starburst dwarf galaxies. In this first paper, we present the observations, color-magnitude diagrams (CMDs), and the SFHs of the 18 starburst galaxies, based on a homogeneous approach to the data reduction, differential extinction, and treatment of photometric completeness. We adopt a star formation rate (SFR) threshold normalized to the average SFR of the individual system as a metric for classifying starbursts in SFHs derived from resolved stellar populations. This choice facilitates finding not only the currently bursting galaxies but also 'fossil' bursts increasing the sample size of starburst galaxies in the nearby (D 100 Myr temporal baseline is thus fundamental to any starburst definition or identification method. The longer lived bursts rule out rapid 'self-quenching' of starbursts on global scales. The bursting galaxies' gas consumption timescales are shorter than the Hubble time for all but one galaxy confirming the short-lived nature of starbursts based on fuel limitations. Additionally, we find that the strength of the Hα emission usually correlates with the CMD-based SFR during the last 4-10 Myr. However, in four cases, the Hα emission is significantly less than what is expected for models of starbursts; the discrepancy is due to the SFR changing on timescales of a few Myr. The inherently short timescale of the Hα emission limits identifying galaxies as starbursts based on the current characteristics which may or may not be representative of the recent SFH of a galaxy.

  14. Eighteen-month Clinical Study of Universal Adhesives in Noncarious Cervical Lesions.

    Science.gov (United States)

    Ruschel, V C; Shibata, S; Stolf, S C; Chung, Y; Baratieri, L N; Heymann, H O; Walter, R

    To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention. Restorations were finished immediately after placement and scored with regard to retention, marginal discoloration, marginal adaptation, and secondary caries. Similar assessment of the restorations was performed 18 months after placement. Logistic regression was performed for each outcome separately with a compound symmetric variance-covariance structure assumed to consider a correlation of restorations within subjects. All analyses were conducted using SAS version 9.4 (SAS Inc). One hundred and fifty-eight teeth (77.8% of the restorations placed) in 46 subjects (73% of subjects enrolled) were available for the 18-month follow-up. A statistically significant difference was reached only for the comparison Scotchbond Universal/self-etch (SU_SE) and Prime & Bond Elect/etch-and-rinse (PBE_E&R) groups ( p=0.01), where a restoration with SU_SE was 66% less likely to maintain a score of Alpha for marginal discoloration than a restoration performed with PBE_E&R. Scotchbond Universal and Prime & Bond Elect presented acceptable clinical performance after 18 months of clinical service. However, Scotchbond Universal, when applied with a self-etch approach, did demonstrate a relatively high level of marginal discoloration when compared to the other groups.

  15. Computer Vision Syndrome in Eleven to Eighteen-Year-Old Students in Qazvin

    Directory of Open Access Journals (Sweden)

    Khalaj

    2015-08-01

    Full Text Available Background Prolonged use of computers can lead to complications such as eye strain, eye and head aches, double and blurred vision, tired eyes, irritation, burning and itching eyes, eye redness, light sensitivity, dry eyes, muscle strains, and other problems. Objectives The aim of the present study was to evaluate visual problems and major symptoms, and their associations among computer users, aged between 11 and 18 years old, residing in the Qazvin city of Iran, during year 2010. Patients and Methods This cross-sectional study was done on 642 secondary to pre university students who had referred to the eye clinic of Buali hospital of Qazvin during year 2013. A questionnaire consisting of demographic information and 26 questions on visual effects of the computer was used to gather information. Participants answered all questions and then underwent complete eye examinations and in some cases cycloplegic refraction. Visual acuity (VA was measured with a logMAR in six meters. Refraction errors were determined using an auto refractometer (Potece and Heine retinoscope. The collected data was then analyzed using the SPSS statistical software. Results The results of this study indicated that 63.86% of the subjects had refractive errors. Refractive errors were significantly different in children of different genders (P < 0.05. The most common complaints associated with the continuous use of computers were eyestrain, eye pain, eye redness, headache, and blurred vision. The most prevalent (81.8% eye-related problem in computer users was eyestrain and the least prevalent was dry eyes (7.84%. In order to reduce computer related problems 54.2% of the participants suggested taking enough rest, 37.9% recommended use of computers only for necessary tasks, while 24.4% and 19.1% suggested the use of monitor shields and proper working distance, respectively. Conclusions Our findings revealed that using computers for prolonged periods of time can lead to eye-related problems such as eyestrain, headaches, weak and tired eyes, blurred and double vision, weak vision, burning itching and watery eyes, etc. To correct and reduce these problems the following precautions may be helpful, using computer shields (anti-reflex glasses, proper computer workplace illumination, enough rest after working with computers, appropriate viewing distances during computer work, placing computers far from bright objects and adjusting a line of vision with the top of the monitor.

  16. An eighteen-membered macrocyclic ligand for actinium-225 targeted alpha therapy

    International Nuclear Information System (INIS)

    Thiele, Nikki A.; MacMillan, Samantha N.; Wilson, Justin J.; Rodriguez-Rodriguez, Cristina

    2017-01-01

    The 18-membered macrocycle H 2 macropa was investigated for 225 Ac chelation in targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar concentration, complexed all 225 Ac (26 kBq) in 5 min at RT. [ 225 Ac(macropa)] + remained intact over 7 to 8 days when challenged with either excess La 3+ ions or human serum, and did not accumulate in any organ after 5 h in healthy mice. A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. Both constructs rapidly radiolabeled 225 Ac in just minutes at RT, and macropa-Tmab retained >99 % of its 225 Ac in human serum after 7 days. In LNCaP xenograft mice, 225 Ac-macropa-RPS-070 was selectively targeted to tumors and did not release free 225 Ac over 96 h. These findings establish macropa to be a highly promising ligand for 225 Ac chelation that will facilitate the clinical development of 225 Ac TAT for the treatment of soft-tissue metastases. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. Biological and clinical dosimetry. Comprehensive eighteen-year report, July 1, 1964-June 30, 1982

    International Nuclear Information System (INIS)

    Laughlin, J.S.; Zeitz, L.

    1982-01-01

    The objectives are to develop and apply primary and secondary dosimetric systems for measurements in the complex radiation fields currently in use for radiobiological research and advanced radiation oncology. The concept of local absorbed dose calorimetry continues to be applied and further developed using tissue equivalent and other materials. Aspects of a simplified approach to calorimetry with thermistors used as non-isolated-sensors in polystyrene are described. This approach also has the potential of giving accurate absolute absorbed dose measurements in situations where the irradiation time can be limited to about 20 minutes. A non-isolated-sensor calorimeter has also been constructed of A-150 tissue equivalent (TE) plastic. Comparison of the absorbed dose measurements with these two calorimeters, after correction for the known mass energy absorption coefficients, gives a direct determination of the thermal defect of A-150 plastic at different levels of free O 2 content in the material. This will permit a study of various approaches to excluding oxygen. This type of calorimeter is presently also being constructed with solid-water-equivalent plastic, i.e., the material designated WT/SRI by Constantinou. Our previously successful isolated sensor calorimeters are still in operation. With the availability of both isolated and non-isolated absorbed dose calorimeters, of our parallel plate ionization chambers in similar material and geometry, and of specific commercial ion chambers, we are in a unique position not only to compare all of these systems but to examine critically basic assumptions in absorbed dose concepts and the correction factors used in different methodologies

  18. Muscle pathology in myotonic dystrophy: light and electron microscopic investigation in eighteen patients.

    Science.gov (United States)

    Nadaj-Pakleza, A; Lusakowska, A; Sułek-Piątkowska, A; Krysa, W; Rajkiewicz, M; Kwieciński, H; Kamińska, A

    2011-05-01

    Myotonic dystrophy (DM) is the most common muscular dystrophy in adults. Two known genetic subtypes include DM1 (myotonic dystrophy type 1) and DM2 (myotonic dystrophy type 2). Genetic testing is considered as the only reliable diagnostic criterion in myotonic dystrophies. Relatively little is known about DM1 and DM2 myopathology. Thus, the aim of our study was to characterise light and electron microscopic features of DM1 and DM2 in patients with genetically proven types of the disease. We studied 3 DM1 cases and 15 DM2 cases from which muscle biopsies were taken for diagnostic purposes during the period from 1973 to 2006, before genetic testing became available at our hospital. The DM1 group included 3 males (age at biopsy 15-19). The DM2 group included 15 patients (5 men and 10 women, age at biopsy 26-60). The preferential type 1 fibre atrophy was seen in all three DM1 cases in light microscopy, and substantial central nucleation was present in two biopsies. Electron microscopy revealed central nuclei in all three examined muscle biopsies. No other structural or degenerative changes were detected, probably due to the young age of our patients. Central nucleation, prevalence of type 2 muscle fibres, and the presence of pyknotic nuclear clumps were observed in DM2 patients in light microscopy. Among the ultrastructural abnormalities observed in our DM2 group, the presence of internal nuclei, severely atrophied muscle fibres, and lipofuscin accumulation were consistent findings. In addition, a variety of ultrastructural abnormalities were identified by us in DM2. It appears that no single ultrastructural abnormality is characteristic for the DM2 muscle pathology. It seems, however, that certain constellations of morphological changes might be indicative of certain types of myotonic dystrophy.

  19. Eighteen-Month Final Evaluation of UPS Second Generation Diesel Hybrid-Electric Delivery Vans

    Energy Technology Data Exchange (ETDEWEB)

    Lammert, M.; Walkowicz, K.

    2012-09-01

    A parallel hybrid-electric diesel delivery van propulsion system was evaluated at a UPS facility in Minneapolis using on-vehicle data logging, fueling, and maintenance records. Route and drive cycle analysis showed different duty cycles for hybrid vs. conventional delivery vans; routes were switched between the study groups to provide a valid comparison. The hybrids demonstrated greater advantage on the more urban routes; the initial conventional vans' routes had less dense delivery zones. The fuel economy of the hybrids on the original conventional group?s routes was 10.4 mpg vs. 9.2 mpg for the conventional group on those routes a year earlier. The hybrid group's fuel economy on the original hybrid route assignments was 9.4 mpg vs. 7.9 mpg for the conventional group on those routes a year later. There was no statistically significant difference in total maintenance cost per mile or for the vehicle total cost of operation per mile. Propulsion-related maintenance cost per mile was 77% higher for the hybrids, but only 52% more on a cost-per-delivery-day basis. Laboratory dynamometer testing demonstrated 13%-36% hybrid fuel economy improvement, depending on duty cycle, and up to a 45% improvement in ton-mi/gal. NOx emissions increased 21%-49% for the hybrids in laboratory testing.

  20. Community Energy Systems and the Law of Public Utilities. Volume Eighteen. Kansas

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L

    1981-01-01

    A detailed description is given of the laws and programs of the State of Kansas governing the regulation of public energy utilities, the siting of energy generating and transmission facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities - Volume One: An Overview. This report also contains a summary of a strategy described in Volume One - An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

  1. Monteggia fracture dislocation equivalents - analysis of eighteen cases treated by open reduction and internal fixation

    Directory of Open Access Journals (Sweden)

    Singh Ajay Pal

    2012-02-01

    Full Text Available 【Abstract】 Objective: Monteggia fracture dislocation equivalent, though already described by Bado, is still an unclassified entity. We aimed to retrospectively analyze 18 cases of Monteggia variants and discuss the injury mechanisms, management, and outcome along with a review of the literature. Methods: A retrospective record of Monteggia fracture dislocation (2003-2008 was reviewed from medical record department of our institute. Classic Monteggia fracture dislocation, children below 12 years or adults over 50 years, as well as open grade II & III cases were excluded from this study. Monteggia variant inclusion criteria included fracture of the proximal ulna together with a fracture of the radial head or neck and skeletal maturity. Totally 26 patients were identified with Monteggia variants and 18 were available for follow-up, including 11 males and 7 females with the mean age of 35 years. The ulna fracture was treated by compression plating along with tension band wiring. Radial head/neck was reconstructed in 12 patients while excised in 6 patients. Results: Follow-up ranged from 1-4 years, mean 2.6 years. Patients were assessed clinicoradiologically. Mayo Elbow Performance Score was employed to assess the outcomes. At final follow-up, the results were excellent in 10 patients, good in 4, fair in 2 and poor in 2. Mean range of motion of the elbow was 20°, 116°, 50° and 55° for extension, flexion, pronation and supination, respectively. Two patients had complications in the form of heterotopic ossification and stiffness of the elbow. One nonunion ulna, primarily treated by tension band wiring, was managed by refixation with locking reconstruction plate and bone grafting. Bone grafting was only required in this patient for nonunion. Another patient had implants removed on his request. The results in our series closely correlated with extent of intraarticular damage, coronoid fracture and comminuted fractures. Conclusions: Monteggia fracture dislocation equivalents are rare injuries and pre-surgery recognition by radiographs and 3-D CT helps make optimal plan. The poor results usually relate to intraarticular damage, coronoid fractures and comminution of the ulna and radial head fractures. Key words: Monteggia’s fracture; Radius fracture; Ulna

  2. A Volunteer Program for Abnormal Psychology Students: Eighteen Years and Still Going Strong.

    Science.gov (United States)

    Scogin, Forrest; Rickard, Henry C.

    1987-01-01

    A volunteer experience in abnormal psychology is described. The program has been operating for 18 years, and student reactions have been quite positive. The program augments the traditional course offerings and provides reciprocal service for the University of Alabama and mental health facilities. Guidelines for implementing a volunteer program…

  3. Characterization of RNA isolated from eighteen different human tissues: results from a rapid human autopsy program.

    Science.gov (United States)

    Walker, Douglas G; Whetzel, Alexis M; Serrano, Geidy; Sue, Lucia I; Lue, Lih-Fen; Beach, Thomas G

    2016-09-01

    Many factors affect the integrity of messenger RNA from human autopsy tissues including postmortem interval (PMI) between death and tissue preservation and the pre-mortem agonal and disease states. In this communication, we describe RNA isolation and characterization of 389 samples from 18 different tissues from elderly donors who were participants in a rapid whole-body autopsy program located in Sun City, Arizona ( www.brainandbodydonationprogram.org ). Most tissues were collected within a PMI of 2-6 h (median 3.15 h; N = 455), but for this study, tissue from cases with longer PMIs (1.25-29.25 h) were included. RNA quality was assessed by RNA integrity number (RIN) and total yield (ng RNA/mg tissue). RIN correlated with PMI for heart (r = -0.531, p = 0.009) and liver (r = -558, p = 0.0017), while RNA yield correlated with PMI for colon (r = -485, p = 0.016) and skin (r = -0.460, p = 0.031). RNAs with the lowest integrity were from skin and cervix where 22.7 and 31.4 % of samples respectively failed to produce intact RNA; by contrast all samples from esophagus, lymph node, jejunum, lung, stomach, submandibular gland and kidney produced RNA with measurable RINs. Expression levels in heart RNA of 4 common housekeeping normalization genes showed significant correlations of Ct values with RIN, but only one gene, glyceraldehyde-3 phosphate dehydrogenase, showed a correlation of Ct with PMI. There were no correlations between RIN values obtained for liver, adrenal, cervix, esophagus and lymph node and those obtained from corresponding brain samples. We show that high quality RNA can be produced from most human autopsy tissues, though with significant differences between tissues and donors. The RNA stability and yield did not depend solely on PMI; other undetermined factors are involved, but these do not include the age of the donor.

  4. Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi.

    Directory of Open Access Journals (Sweden)

    Robin A Ohm

    Full Text Available The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemibiotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core genes. Gene order appears to have been rearranged mostly within chromosomal boundaries by multiple inversions, in extant genomes frequently demarcated by adjacent simple repeats. Several Dothideomycetes contain one or more gene-poor, transposable element (TE-rich putatively dispensable chromosomes of unknown function. The 18 Dothideomycetes offer an extensive catalogue of genes involved in cellulose degradation, proteolysis, secondary metabolism, and cysteine-rich small secreted proteins. Ancestors of the two major orders of plant pathogens in the Dothideomycetes, the Capnodiales and Pleosporales, may have had different modes of pathogenesis, with the former having fewer of these genes than the latter. Many of these genes are enriched in proximity to transposable elements, suggesting faster evolution because of the effects of repeat induced point (RIP mutations. A syntenic block of genes, including oxidoreductases, is conserved in most Dothideomycetes and upregulated during infection in L. maculans, suggesting a possible function in response to oxidative stress.

  5. An Asymptomatic Foreign Body in the Nose in an Eighteen-Year-Old Patient: Button Battery

    Directory of Open Access Journals (Sweden)

    Merih Onal

    2015-01-01

    Full Text Available Foreign bodies lodged in the upper airway are a common occurrence in children. Many unusual foreign bodies in the nose have been reported as foreign bodies like nuts, plastic toy parts, beads, and so forth. Most of these produce minimal morbidity but button batteries due to their early chemical disintegration require early surgical intervention. Here, we report a case of button battery lodged in the nose for several years with a symptom of nasal obstruction and chronic sinusitis.

  6. Knowlton's cactus (Pediocactus knowltonii): Eighteen years of monitoring and recovery actions

    Science.gov (United States)

    Robert C. Sivinski; Charlie McDonald

    2007-01-01

    Pediocactus knowltonii is a rare, endemic cactus that is presently known to occur on a single 10-hectare hill in northwestern New Mexico near the Colorado border. It was listed as federally endangered in 1979. Population monitoring and recovery actions were initiated when the Recovery Plan was adopted in 1985. The land at the type locality has been...

  7. Six to eighteen-month-old children's food intake in day-care centers

    OpenAIRE

    Spinelli, Mônica Glória Neumann; Goulart, Rita Maria Monteiro; Santos, Arali Luiza Primo; Gumiero, Ludimila Di Carla; Farhud, Cláudia Carvalheira; Freitas, Érica Barbosa de; Dantas, Ludmila Ferreira

    2003-01-01

    OBJETIVO: Verificar o consumo alimentar de crianças entre 6 e 18 meses e avaliar a adequação de nutrientes. MÉTODOS: O estudo foi realizado com 106 crianças em creches do Município de São Paulo. Para verificar o consumo alimentar utilizou-se o método de pesagem direta, durante cinco dias. Para análise dos macro e micronutrientes utilizaram-se as referências Organización Mundial de la Salud 1985 e Dietary Reference Intakes 1997, e para fibras adotou-se a recomendação da American Academy of Ped...

  8. An eighteen-membered macrocyclic ligand for actinium-225 targeted alpha therapy

    Energy Technology Data Exchange (ETDEWEB)

    Thiele, Nikki A.; MacMillan, Samantha N.; Wilson, Justin J. [Cornell Univ., Ithaca, NY (United States). Chemistry and Chemical Biology; Brown, Victoria; Jermilova, Una; Ramogida, Caterina F.; Robertson, Andrew K.H.; Schaffer, Paul; Radchenko, Valery [TRIUMF, Vancouver, BC (Canada). Life Science Div.; Kelly, James M.; Amor-Coarasa, Alejandro; Nikolopoulou, Anastasia; Ponnala, Shashikanth; Williams, Clarence Jr.; Babich, John W. [Radiology, Weill Cornell Medicine, New York, NY (United States); Rodriguez-Rodriguez, Cristina [British Columbia Univ., Vancouver, BC (Canada). Dept. of Physics and Astronomy and Centre for Comparative Medicine

    2017-11-13

    The 18-membered macrocycle H{sub 2}macropa was investigated for {sup 225}Ac chelation in targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar concentration, complexed all {sup 225}Ac (26 kBq) in 5 min at RT. [{sup 225}Ac(macropa)]{sup +} remained intact over 7 to 8 days when challenged with either excess La{sup 3+} ions or human serum, and did not accumulate in any organ after 5 h in healthy mice. A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. Both constructs rapidly radiolabeled {sup 225}Ac in just minutes at RT, and macropa-Tmab retained >99 % of its {sup 225}Ac in human serum after 7 days. In LNCaP xenograft mice, {sup 225}Ac-macropa-RPS-070 was selectively targeted to tumors and did not release free {sup 225}Ac over 96 h. These findings establish macropa to be a highly promising ligand for {sup 225}Ac chelation that will facilitate the clinical development of {sup 225}Ac TAT for the treatment of soft-tissue metastases. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  9. Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungi

    Energy Technology Data Exchange (ETDEWEB)

    Ohm, Robin A.; Feau, Nicolas; Henrissat, Bernard; Schoch, Conrad L.; Horwitz, Benjamin A.; Barry, Kerrie W.; Condon, Bradford J.; Copeland, Alex C.; Dhillon, Braham; Glaser, Fabian; Hesse, Cedar N.; Kosti, Idit; LaButti, Kurt; Lindquist, Erika A.; Lucas, Susan; Salamov, Asaf A.; Bradshaw, Rosie E.; Ciuffetti, Lynda; Hamelin, Richard C.; Kema, Gert H. J.; Lawrence, Christopher; Scott, James A.; Spatafora, Joseph W.; Turgeon, B. Gillian; Wit, Pierre J. G. M. de; Zhong, Shaobin; Goodwin, Stephen B.; Grigoriev, Igor V.

    2012-02-29

    The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core) genes. Gene order appears to have been rearranged mostly within chromosomal boundaries by multiple inversions, in extant genomes frequently demarcated by adjacent simple repeats. Several Dothideomycetes contain one or more gene-poor, transposable element (TE)-rich putatively dispensable chromosomes of unknown function. The 18 Dothideomycetes offer an extensive catalogue of genes involved in cellulose degradation, proteolysis, secondary metabolism, and cysteine-rich small secreted proteins. Ancestors of the two major orders of plant pathogens in the Dothideomycetes, the Capnodiales and Pleosporales, may have had different modes of pathogenesis, with the former having fewer of these genes than the latter. Many of these genes are enriched in proximity to transposable elements, suggesting faster evolution because of the effects of repeat induced point (RIP) mutations. A syntenic block of genes, including oxidoreductases, is conserved in most Dothideomycetes and upregulated during infection in L. maculans, suggesting a possible function in response to oxidative stress.

  10. Literacy and Workplace Change: Evaluation Findings from Eighteen Workplace Literacy Programs

    Science.gov (United States)

    Benseman, John

    2012-01-01

    Many Western governments are looking to workplace literacy, language, and numeracy programs to address general skill improvement with a longterm aim of improving labor productivity. Rigorous research on these programs' effectiveness for both of these agendas, however, remains sparse and limited in scope. This article reports the findings of an…

  11. Eighteen cases of small breast cancer: a comparative study of mammography, CT scan and pathology

    International Nuclear Information System (INIS)

    Wu Yaopan; Lin Haogao; Cai Peiqiang; Ouyang Yi; Zhang Weizhang; Lu Bingui

    2003-01-01

    Objective: To improve the early diagnosis of breast cancer through a study of the mammography and CT findings of small breast cancer. Methods: The mammography and CT findings of 18 cases of small breast cancer (φ≤2.0 cm in diameter) were studied and compared with pathological results. Results: The diagnostic accuracy of CT and mammography was 83% and 61%, respectively. There was a statistical difference between both modalities (P<0.05), CT scan was superior to mammography. However, there was no difference between them when assessing the lesion arising in F-type breast. In detecting breast fine cluster of calcification, the sensitivity of mammography was better than CT scan. Conclusion: The patient suspected of small breast cancer should take mammography as the first evaluation. CT scan is reserved for the further investigation. The mammography combined with CT scan can improve the early diagnostic rate of breast cancer

  12. Brief Intervention Impact on Truant Youths' Marijuana Use: Eighteen-Month Follow-Up

    Science.gov (United States)

    Dembo, Richard; Briones-Robinson, Rhissa; Schmeidler, James; Wareham, Jennifer; Ungaro, Rocío; Winters, Ken C.; Karas, Lora; Wothke, Werner; Belenko, Steven

    2016-01-01

    School truancy among teenagers remains a serious national problem, as evidenced by its significant association with school performance, psychological, and behavioral problems. Truancy is also positively associated with substance abuse. This study presents 18-month outcome data from a National Institute on Drug Abuse (NIDA)-funded controlled trial…

  13. Mixed methods analysis of eighteen worksite policies, programs, and environments for physical activity.

    Science.gov (United States)

    Hipp, J Aaron; Dodson, Elizabeth A; Lee, Jung Ae; Marx, Christine M; Yang, Lin; Tabak, Rachel G; Hoehner, Christine; Marquet, Oriol; Brownson, Ross C

    2017-06-14

    This study examined whether specific worksite supports for physical activity (PA) were associated with total and domain-specific PA. A cross-sectional, telephone-based study was conducted in four Missouri, USA, metropolitan areas in 2012 and 2013. Outcome variables included total PA and sub-domains (leisure, work, travel) measured using the International Physical Activity Questionnaire. Logistic regression determined odds of meeting PA recommendations, given access to and use of 18 unique PA worksite supports. A subsample of 119 participants also wore hip accelerometry for seven consecutive days and maintained a wear-time diary. Access to worksite supports were associated with odds of meeting objective moderate and vigorous (MV) PA above 150 min per week. Among 2013 survey participants, meeting PA recommendations while performing work-related tasks was significantly associated with several supports (e.g., walking maps, stair prompts), as was meeting recommendations during travel (e.g., flextime for PA, incentives for public transportation, walking/bicycling to work). Access to 11 worksite supports increased odds of meeting PA recommendations through leisure-time PA; five supports were associated with total PA. There were significant differences between access to and use of supports. Using objective MVPA, access to worksite challenges and bike storage were significantly associated with five and three times greater odds of meeting 150 min of MVPA per week, respectively. Worksite wellness plans are increasing across the US and employers are eager for evidence-based supports for increasing PA. This study provides insights into the utility of multiple worksite supports for PA to increase odds that employees meet PA recommendations.

  14. Non-Hodgkin's lymphomas in Turkey: eighteen years' experience at the Hacettepe University.

    Science.gov (United States)

    Barista, I; Tekuzman, G; Firat, D; Baltali, E; Kansu, E; Kars, A; Ozisik, Y; Ruacan, S; Uzunalimoğlu, B; Karaağaoğlu, E

    1994-12-01

    In this retrospective study, 470 patients with non-Hodgkin's lymphoma (NHL) who had been followed in the Hacettepe University Medical Oncology Department between 1973 and 1990, were evaluated to establish their epidemiologic, clinical and therapeutic characteristics. Out of 470 patients, 302 (62.2%) were male and 168 (37.8%) were female. The ages ranged from 16 to 85, with a median of 44 years. Constitutional symptoms were present in 46.4% of the patients. According to the Working Formulation, low, intermediate, and high-grade lymphomas comprised 33.4%, 54.9%, and 12.7%, respectively. The most common extranodal presentation was gastrointestinal. The chemotherapy regimens most commonly used were CVP (cyclophosphamide, vincristine, prednisone), BCNOP (bleomycin, cyclophosphamide, mitoxantrone, vincristine, prednisone), CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and CHOP-Bleo (cyclophosphamide, doxorubicin, vincristine, prednisone, bleomycin). The response rates and the survival figures attained with these regimens were not statistically significantly different (P > 0.05). In the Cox multivariate model, pathologic grade, leukopenia, responsiveness to chemotherapy, bone marrow involvement and age were the important factors influencing the disease-free survival, while responsiveness to chemotherapy, age, presence of constitutional symptoms, pathologic grade, extranodal presentation and stage were the important factors influencing the overall survival. The distribution of NHL according to grade and stage was similar to that in western societies, while constitutional symptoms and lymphomas of the small intestine including immunoproliferative small intestinal disease were more common in Turkey.

  15. Non‐Hodgkin's Lymphomas in Turkey: Eighteen Years’Experience at the Hacettepe University

    Science.gov (United States)

    Barista, Ibrahim; Tekuzman, Gülten; Firat, Dinçer; Baltali, Esmen; Kansu, Emin; Kars, Ayse; Özisik, Yavuz; Ruacan, Sevket; Uzunalimoglu, Bedri; Karaagaoglu, Ergun

    1994-01-01

    In this retrospective study, 470 patients with non‐Hodgkin's lymphoma (NHL) who had been followed in the Hacettepe University Medical Oncology Department between 1973 and 1990, were evaluated to establish their epidemiologic, clinical and therapeutic characteristics. Out of 470 patients, 302 (62.2%) were male and 168 (37.8%) were female. The ages ranged from 16 to 85, with a median of 44 years. Constitutional symptoms were present in 46.4% of the patients. According to the Working Formulation, low, intermediate, and high‐grade lymphomas comprised 33.4%, 54.9%, and 12.7%, respectively. The most common extranodal presentation was gastrointestinal. The chemotherapy regimens most commonly used were CVP (cyclophosphamide, vincristine, prednisone), BCNOP (bleomycin, cyclophosphamide, mitoxantrone, vincristine, prednisone), CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and CHOP‐Bleo (cyclophosphamide, doxorubicin, vincristine, prednisone, bleomycin). The response rates and the survival figures attained with these regimens were not statistically significantly different (P > 0.05). In the Cox multivariate model, pathologic grade, leukopenia, responsiveness to chemotherapy, bone marrow involvement and age were the important factors influencing the disease‐free survival, while responsiveness to chemotherapy, age, presence of constitutional symptoms, pathologic grade, extranodal presentation and stage were the important factors influencing the overall survival. The distribution of NHL according to grade and stage was similar to that in western societies, while constitutional symptoms and lymphomas of the small intestine including immunoproliferative small intestinal disease were more common in Turkey. PMID:7531679

  16. A survey for southern delta Scuti variable stars

    International Nuclear Information System (INIS)

    McInally, C.J.; Austin, R.R.D.

    1978-01-01

    Twenty-nine field stars have been tested photoelectrically for short-period variability. Eighteen of these stars have spectral types between A2 and F5 and are not Am stars; of these, six have been discovered to be variable and one is a suspected variable. HD 185969, with a period of 0.361 day, has the longest known period for a star of the delta Scuti type. The predominance of discovered variables with amplitudes close to the detection limit is suggestive of most stars in the instability strip being pulsators. (author)

  17. Reviews Book: Sustainable Energy—Without the Hot Air Equipment: Doppler Effect Unit Book: The Physics of Rugby Book: Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Equipment: Brunel Eyecam Equipment: 200x Digital Microscope Book: The Atom and the Apple: Twelve Tales from Contemporary Physics Book: Physics 2 for OCR Web Watch

    Science.gov (United States)

    2009-09-01

    WE RECOMMEND Sustainable Energy—Without the Hot Air This excellent book makes sense of energy facts and figures Doppler Effect Unit Another simple, effective piece of kit from SEP Plastic Fantastic: How the Biggest Fraud in Physics Shook the Scientific World Intriguing and unique write-up of an intellectual fraud case Brunel Eyecam An affordable digital eyepiece for your microscope 200x Digital Microscope An adjustable digital flexcam for classroom use The Atom and the Apple: Twelve Tales from Contemporary Physics A fascinating round-up of the recent history of physics WORTH A LOOK The Physics of Rugby Book uses sport analogy and context to teach physics concepts Physics 2 for OCR Essential textbook for the course but otherwise pointless WEB WATCH Some free teaching materials are better than those you'd pay for

  18. Twelve years of cooperation in the field of radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Grapengiesser, Sten; Bennerstedt, Torkel

    2005-06-01

    SSI has pursued an international cooperation program since 1992 within the field of radiation protection and emergency preparedness for radiation accidents with the three Baltic countries as main beneficiaries. As the Baltic countries are members of the EU since May 2004, this bilateral support will now be phased out and replaced with other forms of cooperation. During the years passed, a large number of activities have been launched with a total budget of some 14 million ECU. The Baltic radiation protection authorities have played a big role in the cooperation and Baltic ministries, universities, nuclear technology installations and other industries using radiation have also been engaged in the projects. SKI, SKB, Studsvik and the Swedish nuclear power plants should be mentioned as major cooperation partners on the Swedish side. During autumn 2004 when such a large coordinated work program was coming to an end, SSI decided to hold a seminar with the purpose to follow up experiences from the work and discuss coming forms of cooperation. The seminar took place on the 18 of November 2004 and gathered some 80 participants, 29 of which from the Baltic countries. It was opened by Lars-Erik Holm, the SSI Director General, and the three Baltic countries then presented their views and impressions from the passed years of cooperation. The seminar was concluded with a panel discussion on 'How to proceed from today's situation'. The result was that SSI invited to a new coordination meeting during autumn 2005 to follow up and discuss coordination of radiation protection around the Baltic Sea together with the other Nordic radiation protection authorities.

  19. Twelve tips for effective body language for medical educators.

    Science.gov (United States)

    Hale, Andrew J; Freed, Jason; Ricotta, Daniel; Farris, Grace; Smith, C Christopher

    2017-09-01

    A significant proportion of human communication is nonverbal. Although the fields of business and psychology have significant literature on effectively using body language in a variety of situations, there is limited literature on effective body language for medical educators. To provide 12 tips to highlight effective body language strategies and techniques for medical educators. The tips provided are based on our experiences and reflections as clinician-educators and the available literature. The 12 tips presented offer specific strategies to engage learners, balance learner participation, and bring energy and passion to teaching. Medical educators seeking to maximize their effectiveness would benefit from an understanding of how body language affects a learning environment and how body language techniques can be used to engage audiences, maintain attention, control challenging learners, and convey passion for a topic. Understanding and using body language effectively is an important instructional skill.

  20. The Epidemiology of Female Genital Mutilation in Nigeria - A Twelve ...

    African Journals Online (AJOL)

    the prevalence. The practice has several negative health and economic consequences. Culture and tradition are important factors fuelling its persistence. Conclusion: Female genital ... Female genital mutilation (FGM) otherwise known as female genital cutting or female ... without medical indication. This contrasts with male.

  1. Twelve testable hypotheses on the geobiology of weathering

    Science.gov (United States)

    S.L. Brantley; J.P. Megonigal; F.N. Scatena; Z. Balogh-Brunstad; R.T. Barnes; M.A. Bruns; P. van Cappelen; K. Dontsova; H.E. Hartnett; A.S. Hartshorn; A. Heimsath; E. Herndon; L. Jin; C.K. Keller; J.R. Leake; W.H. McDowell; F.C. Meinzer; T.J. Mozdzer; S. Petsch; J. Pett-Ridge; K.S. Pretziger; P.A. Raymond; C.S. Riebe; K. Shumaker; A. Sutton-Grier; R. Walter; K. Yoo

    2011-01-01

    Critical Zone (CZ) research investigates the chemical, physical, and biological processes that modulate the Earth's surface. Here, we advance 12 hypotheses that must be tested to improve our understanding of the CZ: (1) Solar-to-chemical conversion of energy by plants regulates flows of carbon, water, and nutrients through plant-microbe soil networks, thereby...

  2. Twelve tips for successful e-tutoring using electronic portfolios.

    Science.gov (United States)

    Deketelaere, Ann; Degryse, Jan; De Munter, Agnes; De Leyn, Paul

    2009-06-01

    E-tutoring by means of a digital portfolio offers personal guidance in a context in which regular face-to-face contact between supervisor and student is difficult. However, implementing e-tutoring in practice is not always straightforward. This article investigates the conditions for successful e-tutoring of electronic portfolios. A combination of three methods is used: our own experience with e-tutoring, interviews with 14 tutors using an e-portfolio and the answers on questionnaires by 107 students. We present 12 tips to increase the chances of successful e-tutoring when using electronic portfolios. E-tutoring by means of electronic portfolios can be a feasible alternative in contexts in which face-to-face tutoring is difficult.

  3. Twelve previously unknown phage genera are ubiquitous in global oceans.

    Science.gov (United States)

    Holmfeldt, Karin; Solonenko, Natalie; Shah, Manesh; Corrier, Kristen; Riemann, Lasse; Verberkmoes, Nathan C; Sullivan, Matthew B

    2013-07-30

    Viruses are fundamental to ecosystems ranging from oceans to humans, yet our ability to study them is bottlenecked by the lack of ecologically relevant isolates, resulting in "unknowns" dominating culture-independent surveys. Here we present genomes from 31 phages infecting multiple strains of the aquatic bacterium Cellulophaga baltica (Bacteroidetes) to provide data for an underrepresented and environmentally abundant bacterial lineage. Comparative genomics delineated 12 phage groups that (i) each represent a new genus, and (ii) represent one novel and four well-known viral families. This diversity contrasts the few well-studied marine phage systems, but parallels the diversity of phages infecting human-associated bacteria. Although all 12 Cellulophaga phages represent new genera, the podoviruses and icosahedral, nontailed ssDNA phages were exceptional, with genomes up to twice as large as those previously observed for each phage type. Structural novelty was also substantial, requiring experimental phage proteomics to identify 83% of the structural proteins. The presence of uncommon nucleotide metabolism genes in four genera likely underscores the importance of scavenging nutrient-rich molecules as previously seen for phages in marine environments. Metagenomic recruitment analyses suggest that these particular Cellulophaga phages are rare and may represent a first glimpse into the phage side of the rare biosphere. However, these analyses also revealed that these phage genera are widespread, occurring in 94% of 137 investigated metagenomes. Together, this diverse and novel collection of phages identifies a small but ubiquitous fraction of unknown marine viral diversity and provides numerous environmentally relevant phage-host systems for experimental hypothesis testing.

  4. California Women: Activities Guide, Kindergarten through Grade Twelve.

    Science.gov (United States)

    McLean, Marie

    Women have always been an integral part of California's history as shamans, settlers, wives, mothers, workers, inventors, and reformers. Yet the names of California women may not be familiar to many students. This activities guide, which was designed to accompany the poster, "California Women: Courage, Compassion, Conviction," provides…

  5. Stress and memory in humans: twelve years of progress?

    Science.gov (United States)

    Wolf, Oliver T

    2009-10-13

    Stress leads to an enhanced activity of the hypothalamus-pituitary adrenal (HPA) axis resulting in an increased release of glucocorticoids from the adrenal cortex. These hormones influence target systems in the periphery as well as in the brain. The present review paper describes the impact of the human stress hormone cortisol on episodic long-term memory. Starting out with our early observation that stress as well as cortisol treatment impaired declarative memory, experiments by the author are described, which result in an enhanced understanding of how cortisol influences memory. The main conclusions are that stress or cortisol treatment temporarily blocks memory retrieval. The effect is stronger for emotional arousing material independent of its valence. In addition cortisol only influences memory when a certain amount of testing induced arousal occurs. A functional magnetic resonance imaging (fMRI) study suggests that the neuronal correlate of the cortisol induced retrieval blockade is a reduced activity of the hippocampus. In contrast to the effects on retrieval cortisol enhances memory consolidation. Again this effect is often stronger for emotionally arousing material and sometimes occurs at the cost of memory for neutral material. A fMRI study revealed that higher cortisol levels were associated with a stronger amygdala response to emotional stimuli. Thus stimulatory effects of cortisol on this structure might underlie the cortisol induced enhancement of emotional memory consolidation. The findings presented are in line with models derived from experiments in rodents and are of relevance for our understanding of stress associated psychiatric disorders.

  6. Marine Biology and Oceanography, Grades Nine to Twelve. Part II.

    Science.gov (United States)

    Kolb, James A.

    This unit, one of a series designed to develop and foster an understanding of the marine environment, presents marine science activities for students in grades 9-12. The unit, focusing on sea plants/animals and their interactions with each other and the non-living environment, has sections dealing with: marine ecology; marine bacteriology;…

  7. Twelve myths about systematic reviews for health system policymaking rebutted.

    Science.gov (United States)

    Moat, Kaelan A; Lavis, John N; Wilson, Mike G; Røttingen, John-Arne; Bärnighausen, Till

    2013-01-01

    Systematic reviews are increasingly being viewed as important sources of information for policymakers who need to make decisions on different aspects of the health system, often under tight time constraints and with many factors competing for their attention. Unfortunately, a number of misconceptions, or 'myths', stand in the way of promoting their use. The belief that systematic review topics are not relevant to health systems policymaking, that they cannot be found quickly, and that they are not available in formats that are useful for policymakers are but three examples of such myths. This paper uses evidence drawn mainly from Health Systems Evidence, a continuously updated repository of syntheses of health systems research, to counter these and nine other common myths, with the aim of changing the constraining beliefs associated with them, while improving the prospects for the use of systematic reviews in health system policymaking.

  8. Student motivation: the study approaches of grade twelve learners in ...

    African Journals Online (AJOL)

    Research has found that in spite of student potential, as well as resources and facilities found in schools and in higher education institutions, students are not inspired to learn and study voluntarily and to the best of their abilities. Students should first be motivated to learn and study before they can take advantage of their ...

  9. The isolation and characterization of twelve novel microsatellite loci ...

    African Journals Online (AJOL)

    hp

    2013-12-18

    Dec 18, 2013 ... MboI adapter2 (5'-GTCAAGAATTCGGTACCGTCGAC-3') were ligated to the digested products using T4 DNA ligase. The ligated product was hybridized with biotin-labeled sequence repeats (SSR) probes. (GT)15, (CT)15, and the hybrid mixture was incubated with magnetic beads coated with streptavidin.

  10. The Epidemiology of Female Genital Mutilation in Nigeria - A Twelve ...

    African Journals Online (AJOL)

    has scientifically proven health benefits.1, 2 Although of uncertain origin ... Multiple Indicator Cluster Surveys (MICS)16,21,22 also show a gradual ... Research has shown that social factors such as peer pressure .... United Nations against FGM.47 This collaboration ... public, developmental partners, media and healthcare ...

  11. Twelve theses on non-proliferation of nuclear weapons

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    NP is not only a scientific-technical but in particular a political task. For the Federal Republic of Germany this means a special responsibility, and thus the theses were formulated and recommendations derived thereof. The theses deal with the following subjects: The responsibility of the FRG - historical, geostrategic, infrastructural; prolongation of the NPT; international safeguards for civil nuclear technology, the role of the IAEA; regional NP policy; nuclear exports; economic aspects of nuclear energy; plutonium and highly-enriched uranium; research policy; radiological risks; nuclear criminal law; disarmament. There are dissenting votes on some theses. Sweeping political developments let some of the theses adopted by the Working Group in March 1990 become obsolete already. (HSCH) [de

  12. Distribution and diversity of twelve Curcuma species in China.

    Science.gov (United States)

    Zhang, Lanyue; Wei, Jingwen; Yang, Zhiwen; Chen, Feng; Xian, Qiqiu; Su, Ping; Pan, Wanyi; Zhang, Kun; Zheng, Xi; Du, Zhiyun

    2018-02-01

    Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces. The simulated current distributions are close to the actual distribution regions. In the future climate, the suitable areas for four Curcuma species will be extended, while for other three species the regions will be significantly decreased, and thus these valuable resources need protecting.

  13. Twelve tips for using applied improvisation in medical education.

    Science.gov (United States)

    Hoffmann-Longtin, Krista; Rossing, Jonathan P; Weinstein, Elizabeth

    2018-04-01

    Future physicians will practice medicine in a more complex environment than ever, where skills of interpersonal communication, collaboration and adaptability to change are critical. Applied improvisation (or AI) is an instructional strategy which adapts the concepts of improvisational theater to teach these types of complex skills in other contexts. Unique to AI is its very active teaching approach, adapting theater games to help learners meet curricular objectives. In medical education, AI is particularly helpful when attempting to build students' comfort with and skills in complex, interpersonal behaviors such as effective listening, person-centeredness, teamwork and communication. This article draws on current evidence and the authors' experiences to present best practices for incorporating AI into teaching medicine. These practical tips help faculty new to AI get started by establishing goals, choosing appropriate games, understanding effective debriefing, considering evaluation strategies and managing resistance within the context of medical education.

  14. Twelve years of cooperation in the field of radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Grapengiesser, Sten; Bennerstedt, Torkel

    2005-06-01

    SSI has pursued an international cooperation program since 1992 within the field of radiation protection and emergency preparedness for radiation accidents with the three Baltic countries as main beneficiaries. As the Baltic countries are members of the EU since May 2004, this bilateral support will now be phased out and replaced with other forms of cooperation. During the years passed, a large number of activities have been launched with a total budget of some 14 million ECU. The Baltic radiation protection authorities have played a big role in the cooperation and Baltic ministries, universities, nuclear technology installations and other industries using radiation have also been engaged in the projects. SKI, SKB, Studsvik and the Swedish nuclear power plants should be mentioned as major cooperation partners on the Swedish side. During autumn 2004 when such a large coordinated work program was coming to an end, SSI decided to hold a seminar with the purpose to follow up experiences from the work and discuss coming forms of cooperation. The seminar took place on the 18 of November 2004 and gathered some 80 participants, 29 of which from the Baltic countries. It was opened by Lars-Erik Holm, the SSI Director General, and the three Baltic countries then presented their views and impressions from the passed years of cooperation. The seminar was concluded with a panel discussion on 'How to proceed from today's situation'. The result was that SSI invited to a new coordination meeting during autumn 2005 to follow up and discuss coordination of radiation protection around the Baltic Sea together with the other Nordic radiation protection authorities.

  15. Indian monsoon cycles through the last twelve million years

    Digital Repository Service at National Institute of Oceanography (India)

    Gupta, S.M.

    the planets depict forward drag (backward pull) effect of conjoined planets on Earth’s speed due to synod phenomenon that increases/decreases the length of summer/winter depending on the season of conjunction event. Also shown are the Kuiper meteoritic belt... cycles by amplitude modulation shown as incomplete envelops of larger cycles at ~600-, 5000-, and 8000 years. Synod effect on Earth: The gravitational pull/push of the planets like Venus, Mars, Jupiter, Saturn, Neptune, and the Trans Neptune...

  16. Twelve gordian knots when developing an organizational code of ethics

    NARCIS (Netherlands)

    Kaptein, Muel; Wempe, Johan

    1998-01-01

    Following the example of the many organizations in the United States which have a code of ethics, an increasing interest on the part of companies, trade organizations, (semi-)governmental organizations and professions in the Netherlands to develop codes of ethics can be witnessed. We have been able

  17. Twelve Kids' Albums You Can't Live Without

    Science.gov (United States)

    Truitt, Warren

    2007-01-01

    In the last 10 years, the once-comatose preschool children's music scene has been resuscitated. Many musicians who were rockers in a former lifetime are now parents, and they are writing some terrific tunes for children. In this article, the author presents a list of 12 albums that are terrific for preschool children.

  18. Predictors of Haitian-American Infant Development at Twelve Months.

    Science.gov (United States)

    Widmayer, Susan M.; And Others

    1990-01-01

    Families in urban and rural settings were studied in an investigation of environmental influences on the development of Haitian-American infants. Birthweight and scores on the Home Observation for Measurement of the Environment predicted mental development. Psychomotor development was related to birthweight and household crowding. (PCB)

  19. Trends in Meningococcal Meningitis Over the Past Twelve Years at ...

    African Journals Online (AJOL)

    Aim: To determine the trends in the occurrence of meningococcal meningitis at the University of Nigeria Teaching Hospital (UNTH) Enugu, Nigeria, as well as the antibiotic sensitivity pattern. Materials and Methods: The results of all cerebrospinal fluid samples received by the microbiology laboratory (UNTH), Enugu ...

  20. Runaway Children Twelve Years Later: A Follow-Up.

    Science.gov (United States)

    Olson, Lucy; And Others

    1980-01-01

    This study was based on intensive interviews with former runaways, nonrunaway siblings, parents, and other relatives. Differences in outcome were found between: (1) runaways and siblings; (2) runaway repeaters and nonrepeaters; and (3) runaways from working-class and middle-class backgrounds. (Author)

  1. Twelve Ways to Build CMS Crossings from ROOT Files

    CERN Document Server

    Chamont, D

    2003-01-01

    The simulation of CMS raw data requires the random selection of one hundred and fifty pileup events from a very large set of files, to be superimposed in memory to the signal event. The use of ROOT I/O for that purpose is quite unusual: the events are not read sequentially but pseudo-randomly, they are not processed one by one in memory but by bunches, and they do not contain orthodox ROOT objects but many foreign objects and templates. In this context, we have compared the performance of ROOT containers versus the STL vectors, and the use of trees versus a direct storage of containers. The strategy with best performances is by far the one using clones within trees, but it stays hard to tune and very dependant on the exact use-case. The use of STL vectors could bring more easily similar performances in a future ROOT release.

  2. Twelve tips for integrating leadership development into undergraduate medical education.

    Science.gov (United States)

    Till, Alex; McKimm, Judy; Swanwick, Tim

    2017-10-26

    Healthcare systems need effective leadership. All healthcare professionals can and should "learn to lead" and this requires a clear focus on leadership development from the earliest stages of a career. Within medicine, undergraduate students should be provided with opportunities to thrive and develop their skills in terms of leadership, management and followership. Drawing from the existing evidence base, the authors' expertise and the latest "thought leadership", these 12 tips provide practical guidance to universities and associated provider organizations, and to academic and clinical faculty, on how to integrate leadership development into their undergraduate medical programs. These 12 tips will help educators provide medical education that incorporates leadership as a core part of a professional's identity, and help students gain a deeper understanding of themselves and the teams, organizations and system they work within.

  3. Twelve-month-olds' understanding of intention transfer through communication.

    Science.gov (United States)

    Cheung, Him; Xiao, Wen; Lai, Ching Man

    2012-01-01

    Do infants understand that intention can be transferred through communication? We answered this question by examining 12-month-olds' looking times in a violation-of-expectation paradigm with two human agents. In familiarization, the non-acting agent spoke, clapped her hands, read aloud a book, or remained silent before the acting agent grasped one (the target) of two objects. During test only the non-actor remained, grasping either the target or distractor. The infants looked longer in the distractor than target condition, suggesting violation of expectation, only if the non-actor had spoken or clapped in familiarization. Because the non-actor never had grasped any of the objects in familiarization, the infants' expectation on her behavior could have developed from the understanding that her intention was transferred to the actor, who executed it by grasping the target in familiarization, via speaking and clapping as acts of communication (but not reading aloud and remaining silent).

  4. Sex Differences in Occupational Attainment: A Twelve-Nation Study.

    Science.gov (United States)

    Roos, Patricia A.

    Differences in the occupational attainment patterns of men and women were investigated by using data from 12 industrial societies. The sample consisted of employed persons 20 to 64 years of age working full- or part-time in the United States, Australia, Denmark, Finland, West Germany, Great Britain, Netherlands, Northern Ireland, Norway, Sweden,…

  5. Twelve-year course and outcome predictors of anorexia nervosa.

    Science.gov (United States)

    Fichter, Manfred M; Quadflieg, Norbert; Hedlund, Susanne

    2006-03-01

    The current study presents the long-term course of anorexia nervosa (AN) over 12 years in a large sample of 103 patients diagnosed according to criteria in the 4th ed. of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Assessments were made at the beginning of therapy, at the end of therapy, at the 2-year follow-up, at the 6-year follow-up, and at the 12-year follow-up. Self-rating and an expert-rating interview data were obtained. The participation rate at the 12-year follow-up was 88% of those alive. There was substantial improvement during therapy, a moderate (in many instances nonsignificant) decline during the first 2 years posttreatment, and further improvement from 3 to 12 years posttreatment. Based on a global 12-year outcome score, 27.5% had a good outcome, 25.3% an intermediate outcome, 39.6% had a poor outcome, and 7 (7.7%) were deceased. At the 12-year follow-up 19.0% had AN, 9.5% had bulimia nervosa-purging type (BN-P), 19.0% were classified as eating disorder not otherwise specified (EDNOS). A total of 52.4% showed no major DSM-IV eating disorder and 0% had binge eating disorder (BED). Systematic-strictly empirically based-model building resulted in a parsimonious model including four predictors of unfavorable 12-year outcome explaining 45% of the variance, that is, sexual problems, impulsivity, long duration of inpatient treatment, and long duration of an eating disorder. Mortality was high and symptomatic recovery protracted. Impulsivity, symptom severity, and chronicity were the important factors for predicting the 12-year outcome.

  6. Family Environment and Cognitive Development: Twelve Analytic Models

    Science.gov (United States)

    Walberg, Herbert J.; Marjoribanks, Kevin

    1976-01-01

    The review indicates that refined measures of the family environment and the use of complex statistical models increase the understanding of the relationships between socioeconomic status, sibling variables, family environment, and cognitive development. (RC)

  7. Access. Challenge for Change/Societe Nouvelle Number Twelve.

    Science.gov (United States)

    Prinn, Elizabeth, Ed.; Henaut, Dorothy Todd, Ed.

    This issue of Access, the journal issued periodically by Challenge for Change/Societe Nouvelle, contains two groups of articles. The first focuses upon the Skyriver Project, relating how a project was developed which used film and video tape as a means of helping Alaskan communities to assess their own needs and to advocate for themselves the…

  8. Twelve years before the quantum no-cloning theorem

    Science.gov (United States)

    Ortigoso, Juan

    2018-03-01

    The celebrated quantum no-cloning theorem establishes the impossibility of making a perfect copy of an unknown quantum state. The discovery of this important theorem for the field of quantum information is currently dated 1982. I show here that an article published in 1970 [J. L. Park, Found. Phys. 1, 23-33 (1970)] contained an explicit mathematical proof of the impossibility of cloning quantum states. I analyze Park's demonstration in the light of published explanations concerning the genesis of the better-known papers on no-cloning.

  9. Expand Your Child's Vocabulary: A Twelve-Week Plan.

    Science.gov (United States)

    Smith, Carl B.

    This booklet shows parents how to help their children develop a number of strategies for understanding words by working together on a methodical, 12-week program of word study. Sections of the booklet describe the program week by week. The techniques described are: Read and Use Context; Search for Synonyms, Antonyms, Homonyms; Learn Important…

  10. Embracing the Ambiguity: Twelve Considerations for Holistic Time Management

    Science.gov (United States)

    Bresciani, Marilee J.; Duncan, Allison J.; Cao, Liu Hui

    2010-01-01

    Many people feel overwhelmed by the seemingly never-ending demands of their professional and personal lives. Thinking of one's life as an ongoing journey promotes flexibility and allows one to focus on a current task, while knowing there will be time in the future to complete other tasks or meet other goals later. Research has also shown that…

  11. Twelve Theses on Reactive Rules for the Web

    OpenAIRE

    Bry, François; Eckert, Michael; Patranjan, Paula-Lavinia

    2006-01-01

    Reactivity, the ability to detect events and respond to them automatically through reactive programs, is a key requirement in many present-day information systems. Work on Web Services re ects the need for support of reactivity on a higher abstraction level than just message exchange by HTTP. This article presents the composite event query facilities of the reactive rule-based programming language XChange. Composite events are important in the dynamic world of the Web whe...

  12. Twelve years of cooperation in the field of radiation protection

    International Nuclear Information System (INIS)

    Grapengiesser, Sten; Bennerstedt, Torkel

    2005-06-01

    SSI has pursued an international cooperation program since 1992 within the field of radiation protection and emergency preparedness for radiation accidents with the three Baltic countries as main beneficiaries. As the Baltic countries are members of the EU since May 2004, this bilateral support will now be phased out and replaced with other forms of cooperation. During the years passed, a large number of activities have been launched with a total budget of some 14 million ECU. The Baltic radiation protection authorities have played a big role in the cooperation and Baltic ministries, universities, nuclear technology installations and other industries using radiation have also been engaged in the projects. SKI, SKB, Studsvik and the Swedish nuclear power plants should be mentioned as major cooperation partners on the Swedish side. During autumn 2004 when such a large coordinated work program was coming to an end, SSI decided to hold a seminar with the purpose to follow up experiences from the work and discuss coming forms of cooperation. The seminar took place on the 18 of November 2004 and gathered some 80 participants, 29 of which from the Baltic countries. It was opened by Lars-Erik Holm, the SSI Director General, and the three Baltic countries then presented their views and impressions from the passed years of cooperation. The seminar was concluded with a panel discussion on 'How to proceed from today's situation'. The result was that SSI invited to a new coordination meeting during autumn 2005 to follow up and discuss coordination of radiation protection around the Baltic Sea together with the other Nordic radiation protection authorities

  13. Design report of the disposal canister for twelve fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Raiko, H. [VTT Energy, Espoo (Finland); Salo, J.P. [Posiva Oy, Helsinki (Finland)

    1999-05-01

    The report provides a summary of the design of the canister for final disposal of spent nuclear fuel. The canister structure consists of a cylindrical massive nodular graphite cast iron insert covered by a 50 mm thick copper overlay. The capacity of the canister is 12 assemblies of BWR or VVER 440 fuel. The canister shall be tight with a high probability for about 100 000 years. The good and long lasting tightness requires: (1) The good initial tightness that is achieved by high quality requirements and extensive quality control, (2) The good corrosion resistance, which is obtained by the overpack of oxygen free copper, and (3) Mechanical strength of the canister, that is ensured by analyses (the following loads are considered: hydrostatic pressure, even and uneven swelling pressure of bentonite, thermal effects, and elevated hydrostatic pressure during glaciation. The allowed stresses and strains are set in such a way that reasonable engineering safety factors are obtained in all assessed design base loading cases). The canister shall limit the radiation dose rate outside the canister to minimise the radiolysis of the water in the vicinity of the canister. The canister insert shall keep the fuel assemblies in a subcritical configuration even if the void in the canister is filled with water due to postulated leakage. The design basis of the canister is set, the performed analyses are summarised and the results are assessed and discussed in the report. (orig.) 35 refs.

  14. Evaluation of a twelve-hour/day shift schedule

    International Nuclear Information System (INIS)

    Lewis, P.M.; Swaim, D.J.

    1986-01-01

    In April 1985, the operating crews at the Fast Flux Test Facility near Richland, Washington, changed their rotating shift schedule from an 8-hour to a 12-hour a day work schedule. The primary purpose of the change was to reduce the attrition of operators by increasing their job satisfaction. Eighty-four percent of the operators favored the change. A program was established to evaluate the effects on plant performance, operator alertness, attrition, sleep, health, job satisfaction, and off-the-job satisfaction. Preliminary results from that evaluation program indicate that the 12-hour shift schedule is a reasonable alternative to an 8-hour schedule at this facility

  15. Buphthalmos: a Twelve-year Review at Ibadan | Bekibele | Nigerian ...

    African Journals Online (AJOL)

    Due to lack of appropriate facilities, visual acuity was not assessed objectively in 17 eyes. Conclusion: Buphthalmos is a rare disease in Ibadan and occurs predominantly in males. Majority of cases are bilateral. In this study, trabeculectomy achieved adequate pressure control in the majority of cases and as such, ...

  16. Identification of twelve polymorphic microsatellite loci in the golden ...

    Indian Academy of Sciences (India)

    ONLINE RESOURCES ... Pomacea canaliculata was introduced in Taiwan as human food around 1980 and ... the diversity and functioning of invaded natural wetlands. (Carlsson et ... Management strategies to control an invasive species can.

  17. Adolescent Sexual Behaviour and Practices in Nigeria: A Twelve ...

    African Journals Online (AJOL)

    ... given in this review have the potential to increase sexual awareness in adolescents, encourage contraceptive use and improve adolescent reproductive and sexual health in the country. Keywords: Adolescent sexual behaviour, Adolescent health and development, secondary school students, adolescent pregnancy.

  18. Twelve metropolitan carbon footprints. A preliminary comparative global assessment

    International Nuclear Information System (INIS)

    Sovacool, Benjamin K.; Brown, Marilyn A.

    2010-01-01

    A dearth of available data on carbon emissions and comparative analysis between metropolitan areas make it difficult to confirm or refute best practices and policies. To help provide benchmarks and expand our understanding of urban centers and climate change, this article offers a preliminary comparison of the carbon footprints of 12 metropolitan areas. It does this by examining emissions related to vehicles, energy used in buildings, industry, agriculture, and waste. The carbon emissions from these sources - discussed here as the metro area's partial carbon footprint - provide a foundation for identifying the pricing, land use, help metropolitan areas throughout the world respond to climate change. The article begins by exploring a sample of the existing literature on urban morphology and climate change and explaining the methodology used to calculate each area's carbon footprint. The article then depicts the specific carbon footprints for Beijing, Jakarta, London, Los Angeles, Manila, Mexico City, New Delhi, New York, Sao Paulo, Seoul, Singapore, and Tokyo and compares these to respective national averages. It concludes by offering suggestions for how city planners and policymakers can reduce the carbon footprint of these and possibly other large urban areas. (author)

  19. Design report of the disposal canister for twelve fuel assemblies

    International Nuclear Information System (INIS)

    Raiko, H.; Salo, J.P.

    1999-05-01

    The report provides a summary of the design of the canister for final disposal of spent nuclear fuel. The canister structure consists of a cylindrical massive nodular graphite cast iron insert covered by a 50 mm thick copper overlay. The capacity of the canister is 12 assemblies of BWR or VVER 440 fuel. The canister shall be tight with a high probability for about 100 000 years. The good and long lasting tightness requires: (1) The good initial tightness that is achieved by high quality requirements and extensive quality control, (2) The good corrosion resistance, which is obtained by the overpack of oxygen free copper, and (3) Mechanical strength of the canister, that is ensured by analyses (the following loads are considered: hydrostatic pressure, even and uneven swelling pressure of bentonite, thermal effects, and elevated hydrostatic pressure during glaciation. The allowed stresses and strains are set in such a way that reasonable engineering safety factors are obtained in all assessed design base loading cases). The canister shall limit the radiation dose rate outside the canister to minimise the radiolysis of the water in the vicinity of the canister. The canister insert shall keep the fuel assemblies in a subcritical configuration even if the void in the canister is filled with water due to postulated leakage. The design basis of the canister is set, the performed analyses are summarised and the results are assessed and discussed in the report. (orig.)

  20. Design and Control of a Twelve-Bar Tensegrity Robot

    Data.gov (United States)

    National Aeronautics and Space Administration — A tensegrity (tensional integrity) robot is a lightweight, compliant system consisting of rods suspended in a network of cables. It can absorb large loads on impact,...

  1. Twelve Principles for Green Energy Storage in Grid Applications.

    Science.gov (United States)

    Arbabzadeh, Maryam; Johnson, Jeremiah X; Keoleian, Gregory A; Rasmussen, Paul G; Thompson, Levi T

    2016-01-19

    The introduction of energy storage technologies to the grid could enable greater integration of renewables, improve system resilience and reliability, and offer cost effective alternatives to transmission and distribution upgrades. The integration of energy storage systems into the electrical grid can lead to different environmental outcomes based on the grid application, the existing generation mix, and the demand. Given this complexity, a framework is needed to systematically inform design and technology selection about the environmental impacts that emerge when considering energy storage options to improve sustainability performance of the grid. To achieve this, 12 fundamental principles specific to the design and grid application of energy storage systems are developed to inform policy makers, designers, and operators. The principles are grouped into three categories: (1) system integration for grid applications, (2) the maintenance and operation of energy storage, and (3) the design of energy storage systems. We illustrate the application of each principle through examples published in the academic literature, illustrative calculations, and a case study with an off-grid application of vanadium redox flow batteries (VRFBs). In addition, trade-offs that can emerge between principles are highlighted.

  2. Participatory consumer evaluation of twelve sweetpotato varieties in ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-03-15

    Mar 15, 2010 ... evaluation of preferred sweetpotato varieties for consumption. However ... zones (AEZs) for two seasons in 2005, the Long Rains (LR) and .... 5. 0. 16.6. 0. 0. Educational Level. Below primary. 15. 0. 72.7. 4.5. 15. 0 ... the farmers using a cocoa beverage as this was accepted in the ... of the last tasted variety.

  3. Update from a twelve-year nationwide fungaemia surveillance

    DEFF Research Database (Denmark)

    Astvad, K M T; Johansen, H K; Røder, B L

    2018-01-01

    countries. This was particularly true for the fluconazole and itraconazole use in the primary healthcare sector which exceeded the combined national use of these compounds in each of the other Nordic countries. Fluconazole susceptibility decreased (68.5%, 65.2% and 60.6% in 2004-7, 2008-11 and 2012...

  4. "Twelve Apostles" and a Few Heretics. Historical Paper 1

    Science.gov (United States)

    Shera, Jesse H.

    2015-01-01

    There is much more to learn from reading the biographical and philosophical writings of leaders in higher education about what education for librarianship was and should be than from the literature of library education itself. This article contains an alphabetical list with annotations of 23 books on exploring the issues and problems of higher…

  5. Weed diversity identification on growth phases of twelve maize varieties

    Science.gov (United States)

    Rahayu, M.; Yudono, P.; Indradewa, D.; Hanudin, E.

    2018-03-01

    Weed is one of the factors that disturb maize cultivation. Each maize variety has specific characteristics which will lead to weeds diversity in particular farm. This study aimed to identify the effect of maize variety on weed diversity on maize’s growth phases. The research was conducted from March to July 2016 in Banguntapan, Bantul, Yogyakarta, Indonesia. The field research was arranged by using Randomised Complete Block Design with three replications. The treatments were maize varieties, consist of 12 levels: ‘Bisi 18’, ‘Bisi 2’, ‘Pertiwi 3’, ‘NK 22’, ‘NK 33’, ‘DK 959’, ‘P23’, ‘DK 771’, ‘DK 95’, ‘Bima 19 Uri’, ‘Bisma’, and ‘Sukmaraga’. The results showed that at four weeks after planting (WAP) the most of weeds were growing on varieties ‘Bisi 18’, ‘NK 33’, ‘P 23’, and ‘DK 95’, there were 14 species. Bulbostylispuberula and Cyperusrotundus were growing on all maize varieties with the highest SDR on ‘Sukmaraga’ and ‘DK 959’. At six WAP, weeds that grew, most consists of four species of sedges, six species of grasses and 24 species of broadleaf. While at the age of eight WAP, the weeds that grow at least on ‘NK 33’ that were 13 species and the most on ‘P23’ that were 21 species. Dactyloctenium aeghypthium having highest SDR in all maize varieties except Bisi 18. The highest SDR value on Bisi 18 was Boerhaavia erecta about 16.23%.

  6. Twelve Years in the Life of Airline Websites

    Directory of Open Access Journals (Sweden)

    C. Michael Powell

    2016-04-01

    Full Text Available Perhaps no innovation in history has affected marketing management as pervasively as has the advent of e-commerce. This revolutionary new channel has required businesses to acquire an entirely new set of skills and approaches to promotion, pricing, and distribution. The necessity for e-commerce website operators to more deeply understand consumer behavior when engaged in e-commerce has become a central and crucial factor in website success or failure. As predicted nearly 20 years ago, travel bookings have moved almost entirely to the World Wide Web (WWW. For the past 12 years, data have been collected concerning traveler’s preferences, concerns, and perceptions of airline websites in particular. This research reviews and comments on the evolution of those sites and consumer perceptions of efficiency, ease of use, and usefulness. The results of this study are intended to guide airlines in their pursuit of customer satisfaction and increased profits.

  7. Perfume sensitivity in adult females. A study of contact sensitivity to a perfume mix in two groups of student nurses.

    Science.gov (United States)

    Guin, J D; Berry, V K

    1980-09-01

    The incidence of contact sensitivity to a perfume mix was investigated in two groups of student nurses by questionnaire and patch testing. Twenty-nine of ninety gave a history of dermatitis on exposure to fragrances or perfumed cosmetics. Fifteen of eighty-five showed a positive patch test reaction to a perfume mix comprising 2% concentrations of eight different perfume ingredients, and twelve of the fifteen had a positive history. Chi-square analysis of the data indicates that the results of the two methods of measurements are significantly related (p < 0.0001).

  8. Embodied civic education: The corporeality of a civil body politic

    Directory of Open Access Journals (Sweden)

    Phillips Donna Paoletti

    2014-06-01

    Full Text Available This study explores the lived experience of democratic civic education for middle school students. Grounded in the tradition of hermeneutic phenomenology as guided by Heidegger (1962, Gadamer (1960/2003, Casey (1993, and Levinas (1961/2004, among others, the framework for conducting action-sensitive research, as described by van Manen (2003, guides this inquiry as I endeavor to uncover what it means for students to embody civic education. Twenty-nine students are taped engaging in discussions, debates, simulations, and other civic education. Twelve students self-select to engage in reflective writing and conversations about their experiences.

  9. Estudio exploratorio sobre la presencia del consumo de sustancias psicoactivas en niños entre 10 y 12 años y en sus padres o adultos responsables Preliminary study about the presence of the use of psychoactive substances among children between ten and twelve years old and in their parents or responsible adults

    Directory of Open Access Journals (Sweden)

    Sara Slapak

    2005-12-01

    Full Text Available Se presentan los resultados preliminares de un estudio cuyo propósito es indagar la presencia del consumo de sustancias psicoactivas en niños entre 10 y años y en sus padres o adultos responsables. Metodología: Muestras: niños de a años que reciben asistencia psicoterapéutica en una unidad de docencia en servicio de una cátedra universitaria; padres o adultos responsables de dichos niños. Instrumentos: CORIN. Fuente: CONICET. Cuestionario que indaga hábitos de consumo en los adultos. Anamnesis a los adultos. Protocolo de datos sociodemográficos. Conclusiones: Se registra consumo ocasional de alcohol durante el año de administración del instrumento entre los niños. De la misma manera, se observa un consumo habitual de diversas sustancias psicoactivas en su entorno familiar. Se concluye que el consumo ocasional de alcohol en los niños no se encuentra relacionado con su sintomatología, sino más bien con las características del contexto familiar.This paper presents the preliminaries results of a study which purpose is to inquire the presence of the use of psychoactive substances among children between ten and twelve years old and in their parents or responsible adults. Methodology: Samples: Children between ten and twelve years old that receive psychotherapeutical assistance in an academic unit in a service witch belongs to an university chair; parents or responsible adults of these children. Tools: CORIN. Source: CONICET. Questionnaire that inquires about consume habits in the adults. Adults anamnesis. Sociodemographic data protocol. Conclusions: During the year of the administration of the instrument, it is registred an occasional consume of alcohol among the children. In the same way, it is observed a habitual consume of diverse psychoactive substances in their family context. It is concluded that the occasionally use of alcohol in children it is not related with their sinthomatology, but with the characteristics of their family

  10. Civil War Logistics: Effects of Logistics on the Pea Ridge Campaign

    Science.gov (United States)

    2015-06-12

    twelve ounces of pork or bacon , or twenty ounces of fresh or salt beef; eighteen ounces bread or flour, or twelve ounces hard bread, or twenty ounces of......Vandever 9th Iowa Infantry Lieutenant Colonel Francis J. Herron 25th Missouri Infantry Colonel John S. Phelps 3rd Independent Battery, Iowa Light

  11. Operational experience with the first eighteen slightly enriched uranium fuel assemblies in the Atucha-1 nuclear power plant

    International Nuclear Information System (INIS)

    Higa, M.; Perez, R.; Pineyro, J.; Sidelnik, J.; Fink, J.; Casario, J.A.; Alvarez, L.

    1997-01-01

    Atucha I is a 357 Mwe nuclear station, moderated and cooled with heavy water, pressure vessel type of German design, located in Argentina. Fuel assemblies (FA) are 36 active natural UO2 rod clusters, 5.3 meters long and fuel is on power. Average FA exit burnup is 6 MWd/kg U. The reactor core contains 252 FA. To reduce the fuel costs about 6 MU$S/yr a program of utilization of SEU (0.85 %w U235) fuel was started at the beginning of 1995 with the introduction of 12 FA in the first step. The exit burnup of FA is approx. 10 MWd/kgU. It is planned to increase gradually the number of them up to having a full core with SEU fuel with an expected FA average exit burnup of 11 MWd/kgU. The SEU program has also the advantage of a strong reduction of spent fuel volume, and a moderate reduction of fuelling machine use. This paper presents the satisfactory operation experience with the introduction of the first 12 SEU fuel assemblies and the planned activities for the future. The fresh SEU fuel assemblies were introduced in six fuel channels located in an intermediate zone located 136 cm from the center of the reactor and selected because they have higher margins to the channel powers limits to accommodate the initial 15 to 20 % relative channel power increase. To verify the design and fuel management calculations, comparisons have been made of the calculated and measured values of the variation of channel ΔT, regulating rods insertion and flux reading in in-core detectors near to the refueled channel. The agreement was good and in most of the cases within the measurement errors. Cell calculations were made with WIMS-D4, and reactor calculations with PUMA. a fuel management 3D diffusion program developed in Argentina. With SEU fuel with a greater burnup in the central high power core region, new operating procedures were developed to prevent PCI failures in fuel power ramps that arise during operation. Some fuel rod and structural assembly design changes were introduced on the first 12 SEU FA. Other specific design changes are also being implemented in the next SEU FA series in order to improve the fuel behaviour at higher burnups and in power ramps. (author)

  12. Facing up to Body Art: "As Soon as I Turn Eighteen, I'm Getting a Tattoo"

    Science.gov (United States)

    Strauch-Nelson, Wendy

    2004-01-01

    In this article, the author discusses a lesson she did in one of her high school classes about body art and tattoos. She wanted to explore the reasons for high schoolers wanting tattoos and supply those teenagers with some background and facts about body art in terms of origins, meaning, and permanence. The author feels the time spent on the study…

  13. Ecotoxicological evaluation of the additive butylated hydroxyanisole using a battery with six model systems and eighteen endpoints.

    Science.gov (United States)

    Jos, Angeles; Repetto, Guillermo; Ríos, Juan Carlos; del Peso, Ana; Salguero, Manuel; Hazen, María José; Molero, María Luisa; Fernández-Freire, Paloma; Pérez-Martín, Jose Manuel; Labrador, Verónica; Cameán, Ana

    2005-01-26

    The occurrence and fate of additives in the aquatic environment is an emerging issue in environmental chemistry. This paper describes the ecotoxicological effects of the commonly used additive butylated hydroxyanisole (BHA) using a test battery, comprising of several different organisms and in vitro test systems, representing a proportion of the different trophic levels. The most sensitive system to BHA was the inhibition of bioluminescence in Vibrio fischeri bacteria, which resulted in an acute low observed adverse effect concentration (LOAEC) of 0.28 microM. The next most sensitive system was the immobilization of the cladoceran Daphnia magna followed by: the inhibition of the growth of the unicellular alga Chlorella vulgaris; the endpoints evaluated in Vero (mammalian) cells (total protein content, LDH activity, neutral red uptake and MTT metabolization), mitotic index and root growth inhibition in the terrestrial plant Allium cepa, and finally, the endpoints used on the RTG-2 salmonid fish cell line (neutral red uptake, total protein content, MTS metabolization, lactate dehydrogenase leakage and activity, and glucose-6-phosphate dehydrogenase activity). Morphological alterations in RTG-2 cells were also assessed and these included loss of cells, induction of cellular pleomorphism, hydropic degeneration and induction of apoptosis at high concentrations. The results from this study also indicated that micronuclei were not induced in A.cepa exposed to BHA. The differences in sensitivity for the diverse systems that were used (EC50 ranged from 1.2 to >500 microM) suggest the importance for a test battery approach in the evaluation of the ecological consequences of chemicals. According to the results, the levels of BHA reported in industrial wastewater would elicit adverse effects in the environment. This, coupled with its potential to bioaccumulate, makes BHA a pollutant of concern not only for acute exposures, but also for the long-term.

  14. Implementation experience during an eighteen month intervention to improve paediatric and newborn care in Kenyan district hospitals

    Directory of Open Access Journals (Sweden)

    Wamae Annah

    2009-07-01

    Full Text Available Abstract Background We have conducted an intervention study aiming to improve hospital care for children and newborns in Kenya. In judging whether an intervention achieves its aims, an understanding of how it is delivered is essential. Here, we describe how the implementation team delivered the intervention over 18 months and provide some insight into how health workers, the primary targets of the intervention, received it. Methods We used two approaches. First, a description of the intervention is based on an analysis of records of training, supervisory and feedback visits to hospitals, and brief logs of key topics discussed during telephone calls with local hospital facilitators. Record keeping was established at the start of the study for this purpose with analyses conducted at the end of the intervention period. Second, we planned a qualitative study nested within the intervention project and used in-depth interviews and small group discussions to explore health worker and facilitators' perceptions of implementation. After thematic analysis of all interview data, findings were presented, discussed, and revised with the help of hospital facilitators. Results Four hospitals received the full intervention including guidelines, training and two to three monthly support supervision and six monthly performance feedback visits. Supervisor visits, as well as providing an opportunity for interaction with administrators, health workers, and facilitators, were often used for impromptu, limited refresher training or orientation of new staff. The personal links that evolved with senior staff seemed to encourage local commitment to the aims of the intervention. Feedback seemed best provided as open meetings and discussions with administrators and staff. Supervision, although sometimes perceived as fault finding, helped local facilitators become the focal point of much activity including key roles in liaison, local monitoring and feedback, problem solving, and orientation of new staff to guidelines. In four control hospitals receiving a minimal intervention, local supervision and leadership to implement new guidelines, despite their official introduction, were largely absent. Conclusion The actual content of an intervention and how it is implemented and received may be critical determinants of whether it achieves its aims. We have carefully described our intervention approach to facilitate appraisal of the quantitative results of the intervention's effect on quality of care. Our findings suggest ongoing training, external supportive supervision, open feedback, and local facilitation may be valuable additions to more typical in-service training approaches, and may be feasible.

  15. Eighteen years of geochemical monitoring at the oceanic active volcanic island of El Hierro (Canary Islands, Spain)

    Science.gov (United States)

    Asensio-Ramos, María; Alonso, Mar; Sharp, Emerson; Woods, Hannah; Barrancos, José; Pérez, Nemesio M.

    2016-04-01

    We report herein the latest results of a diffuse CO2 efflux survey at El Hierro volcanic system carried out during the summer period of 2015 to constrain the total CO2 output from the studied area a during post-eruptive period. El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island. On October 10, 2011, the dominant character of seismicity changed dramatically from discrete earthquakes to continuous tremor, a clear indication that magma was rapidly approaching the surface immediately before the onset of the eruption, October 12. Eruption was declared over on 5 March, 2012. In order to monitor the volcanic activity of El Hierro Island, from 1998 to 2015 diffuse CO2 emission studies have been performed at El Hierro volcanic system in a yearly basis (˜600 observation sites) according to the accumulation chamber method. Spatial distribution maps were constructed following the sequential Gaussian simulation (sGs) procedure. To quantify the total CO2 emission from the studied area, 100 simulations for each survey have been performed. During the eruption period, soil CO2 efflux values range from non-detectable (˜0.5 g m-2 d-1) up to 457 g m-2 d-1, reaching in November 27, 2011, the maximum CO2 output estimated value of all time series, 2,398 t d-1, just before the episodes of maximum degassing observed as vigorous bubbling at the sea surface and an increment in the amplitude of the tremor signal. During the 2015 survey, soil CO2 efflux values ranged from non-detectable up to 41 g m-2 d-1. The spatial distribution of diffuse CO2 emission values seemed to be controlled by the main volcano structural features of the island. The total diffuse CO2 output released to atmosphere was estimated at 575 ± 24 t d-1, value slightly higher that the background CO2 emission estimated at 422 t d-1 (Melián et al., 2014). The above data demonstrate that discrete surveys of diffuse CO2 emission provide important information to optimize the early warning system in volcano monitoring programs and to monitor the evolution of an ongoing volcanic eruption, even though it is a submarine eruption. References: Melián et al., 2014. J. Geophys. Res. DOI: 10.1002/2014JB011013.

  16. [2001 national survey of nosocomial infection prevalence among newborns and under-eighteen children and adolescents in France].

    Science.gov (United States)

    Branger, B

    2005-07-01

    To know nosocomial infections (NI) rates among newborns and hospitalised children according to age and units of hospitalisation, In 2001, the Comité technique des infections nosocomiales (CTIN) initiated a one-day prevalence survey on an arranged date. It was conducted by the 5 centres de coordination de lutte contre les infections nosocomiales (C.CLIN). Paediatric data only were analysed dividing them into 2 groups: newborns (NB) up to 28 days old, whether in maternity, neonatology or intensive care units, and children (CH) from 29 days to 18 years old with separate analysis for surgery, cancer units and intermediate care and rehabilitation centres (ICRC). The survey included 21 596 children under 18 years old: 9136 NB and 12,460 CH, i.e. 7.1% of the total hospital population on that one given day. A total of 2.6% of the patients were infected, with 1.2% of NB and 3.3% of CH. There were 1.09 infections per patient. 456 different microorganisms were responsible for 562 infections, i.e. 81.1%: 18,6% Staphylococcus aureus of which 26.7% were methicillin resistant (MRSA), 21.9% Staphylococcus epidermis, 21.9% enterobacteries, 10.3% Pseudomonas aeruginosa, 4.4% Candida albicans, and 4.2% rotavirus. NB and CH infection factors were studied separately. Selective criteria for hospitalised NB were: gender: male(P infected patients in intensive care units was 7.8% for NB and 16.2% for CH, with 9.6% neonatal, 30.8% heart condition, 26.3% non-specialised units and 14.2% children units. ICRC infection rate was 4.5% while surgery units had a rate of 1.9% with 2.4% orthopaedic, 0.7% children units, 2.0% non-specialised units and 8.1% neurosurgery. The 2001 NI level showed a significant fall from 3.5% in the 1996 survey (all ages) to 2.4%. However, including newborns from private maternity units into the survey may have partly lowered this level. MRSA levels have also dropped from 46% in 1996 to 27% in 2001. It is difficult to compare international data as definitions vary. Furthermore, it should be possible to separate newborns from older children as well as specifying the type of units involved. Infected patients levels are generally lower in the French surveys, no matter the age group or units studied than in other surveys. This survey has enabled the monitoring of the children population in maternity units, on a given day, in France. It showed that the rate of NI in the paediatric population seems low compared to previous data or other countries'data. Efforts need to be made in order to lower it further. Incidence surveillance method is preferable to single out which risk factors can be acted upon. Standardized national protocols are offered to maternity units and should soon be available for newborns units as well as older children units.

  17. Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners

    DEFF Research Database (Denmark)

    Brugniaux, Julien V; Schmitt, Laurent; Robach, Paul

    2005-01-01

    The efficiency of "living high, training low" (LHTL) remains controversial, despite its wide utilization. This study aimed to verify whether maximal and/or submaximal aerobic performance were modified by LHTL and whether these effects persist for 15 days after returning to normoxia. Last, we trie...

  18. The Competitive Response Investigation of Eighteen Wheat (Triticum aestivum L. Cultivars with Wild Mustard (Sinapis arvensis L.

    Directory of Open Access Journals (Sweden)

    fatemeh abdolahi

    2018-02-01

    Full Text Available Introduction: The crop competitive ability is an important and profitable factor for increment impact on the weeds, and decreasing their yield loss. Characteristics such as height, leaf area, growth rate and tillering ability could be effective on competitive ability of cultivar ability. Primary growth rate is important on competitiveness, and any other factors that provides fast establishment of crops growth can be effective too. Thus, utilization of cultivars with height competitiveness ability is one of the considerable strategies for integrated weed managements. Many studies had shown that there are high correlation between crop height and its competitiveness ability. Asef et al (2 reported that tall cultivars reduced weed biomass more than dwarf cultivars due to light intercept and shading. Safahani- langrodi et al (32 in competition condition tall cultivars had high weed tolerance and cause to decrease weed biomass and set seed. There are an important relationship between LAI and weed competition. Hiffle et al. (13 showed cultivars with higher leaf area index had a greater yield stability. Dianat et al. (10 reported that in weed competitive conditions, there are significant difference in the number of tillers among wheat cultivars, while competitor and non-competitor cultivars have most and lowest tiller numbers respectively. Nadery and Ghadiri (25 showed that increasing wild mustard density decreased tiller number and more yield loss in weed competition have caused by decreased number of tillers. Materials and Methods: Experiment was conducted in order to study morphological characteristics and yield of wheat (T. aestivum cultivars in wild mustard (Sinapis arvensis L. competition in greenhouse, University of Mohaghegh Ardabili, during 2013-2014. Treatments were 18 wheat cultivars [Karkheh, Alborz, Azadi, Shahpasand, Sepahan, Flat, Ghods, Roshan, Sorkh¬tokhm, Moghan3, Alvand, MS-81-14, Yarvarus, Shahriyar, Golestn, Bam, Niknajad, Karaj3] with and without competition. Treatments were arranged in a factorial experiment based on randomized complete block design with three replications. Each pot was filled with almost 5 kg soil mixture of sand and manure. In each pot 15 wheat seeds along or with wild mustard seeds had sown. In the spring after establishment of wheat seedlings, pots were thinned and 6 wheat seedling in each pots and only one established wild mustard was remained. At tillering stage, tillering numbers in 3 wheat plants were counted. Leaf area was calculated by Ross (28 and Pearcy et al. (27 method at heading stage then leaf area index was estimated by following equation. Leaf area= K× (leaf length × maximum leaf width In which: K is constant coefficient (K = 0.75. Light penetration within canopy and soil surface was measured by Lux meter version (LX-101. Wheat and wild mustard coverage were assessed visually (34, 23. All trails that involving yield such as (spike number, seeds number per spike and thousand seeds weight, at ripening stage of all wheat in the pots measured and weighted. Data were subjected to ANOVA, and means were separated using Fisher’s Protected LSD test at 0.05 probability (P ≤ 0.05. Results: Analysis showed that wheat cultivars had a significant effect on tillers number, but wild mustard competition had no significant effect (P ≤ 0.05. Means comparison showed that Alvand, Alborz, and Bam cultivars have 8 tillers and Flat only 2 tillers. Also, wheat cultivars at the stem elongation had significant difference on the leaf area but, wild mustard competition effects and interaction effects were did not a significant effects on the mentioned factor (P ≤ 0.05. Between wheat cultivars Alvand had maximum (1.09 and Alborz, Sepahan, Roshan and Flat had minimum leaf area. Wheat coverage at both tillering and stem elongation was different between wheat cultivars. At tillering stage, wheat coverage ranged 7.16 – 53.3, so Alvand and Bam had maximum and Flat and Ghods had lowest amount. Results revealed that, there was significant difference between cultivars light penetration percentage within canopy and soil surface. Wheat yield was influenced under wheat cultivars and wild mustard competition and interaction effects (P ≤ 0.05. Conclusion: It has been hypothesized that increased crop density and spatial distribution and uniformity can increase weed suppression and thereby play an important role in weed management. This study results showed that, the means of light penetration percentage into soil surface on wild mustard competition were %9.82 in weed free and %13.69 in weedy treatments, also biological and economic yield reduced by %13.5 and %26, respectively. Although cultivars recommendation for each specific local area requires too long term studies (in time and site, but results of this study, well documented canopy architecture in view of more tillering potency for Alvand, Bam and Albors cultivars and %50 light penetration reached up to canopy middle for other cultivars such as Karkh, Alborz, Golestn and MS-81-14, which appear to be implemented in integrated weed managements design options.

  19. Wiskott-Aldrich Syndrome With Normal-Sized Platelets in an Eighteen-Month-Old Boy: A Rare Mutation

    Directory of Open Access Journals (Sweden)

    Jayitri Mazumdar

    2015-07-01

    Full Text Available Introduction: Wiskott-Aldrich syndrome (WAS is an X-linked recessive disorder characterized by thrombocytopenia, eczema, and recurrent infections. The disease is usually associated with small defective platelets. Case Presentation: We described an 18-month-old boy who presented with lower gastrointestinal bleeding, eczema, and recurrent infections. There was pancytopenia with normal-sized platelets. In addition, the CD4 count was significantly low and serum IgA and IgE levels were increased. The diagnosis of WAS was confirmed by detecting a mutation of WAS gene, which was due to a deletion mutation resulting in frameshift (c.177DelT. Conclusions: Usually microplatelets with mean platelet volume of 4-5 fL are seen in WAS, but in this case, the patient had normal-sized platelets with a rare mutation of WAS gene. Therefore, high index of clinical suspicion is needed to diagnose WAS.

  20. Group B streptococcal bacteremia in a major teaching hospital in Malaysia: a case series of eighteen patients.

    Science.gov (United States)

    Eskandarian, N; Neela, V; Ismail, Z; Puzi, S M; Hamat, R A; Desa, M N M; Nordin, S A

    2013-09-01

    Group B Streptococcus (GBS) is a leading cause of infections such as meningitis and septicemia in neonates and pregnant women; however the significance of invasive GBS disease has not been clearly defined in non-pregnant adults. We reviewed the hospital records of 18 cases with GBS bacteremia who attended the Universiti Kebangsaan Malaysia Medical Centre from June 2010 to October 2011. We analyzed the clinical findings of both bacteremic adults and neonates and compared them to previous studies of GBS bacteremia. Serotyping was done by latex agglutination test using 10 distinct antisera (Ia, Ib, and II-IX). During the period of 1 year and 4 months, there were 18 patients with GBS bacteremia. Five cases occurred in neonates, one in a parturient woman, and 12 in other adults. All neonates with bacteremia were males and two of them were premature. Septicemia was the most common clinical presentation in neonates. They were treated with intravenous (IV) penicillin G and gentamicin. The adults included nine men (69%) and four women (31%). Their mean age was 60 years and all patients had more than two underlying conditions. The most common clinical syndrome was pneumonia (n=6, 46.5%). The others were peritonitis (n=3, 23.1%), primary bacteremia (n=2, 15.5%), septic arthritis (n=2, 15.5%), skin and soft tissue infection (n=1, 7.7%), meningitis (n=1, 8%), urinary tract infection (n=1, 8%), and intravascular device infection (n=1, 7.7%). Cardiovascular diseases (n=7, 53.8%) were the most common underlying conditions, and diabetes mellitus (n=5, 38.5%) was second. The other co-morbid conditions were hyperlipidemia (n=3, 23.1%), renal disease (n=3, 23.1%), liver disease and/or alcohol abuse (n=3, 23.1%), autoimmune disease or immunosuppressive condition (n=2, 15.5%), malignancy (n=2, 15.5%), respiratory disease (n=1, 8%), and postpartum condition (n=1, 8%), as well as miscellaneous conditions including intravenous drug abuse, HIV infection, and trauma (n=2, 15.5%). Polymicrobial bacteremia was found in five (45.4%) cases and Staphylococcus aureus was the most common concurrent bacterial isolate. Of the 18 GBS isolates in both adults and neonates, serotype Ia was predominant (38.9%), followed by VI (27.8%), V (11.1%), and III (5.5%); the remaining 16.7% were non-typeable. GBS bacteremia is a significant problem and is associated with serious underlying disease, which may result in a high rate of mortality, not only in neonates and pregnant women, but also in non-pregnant adults. Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  1. Science Library of Test Items. Volume Eighteen. A Collection of Multiple Choice Test Items Relating Mainly to Chemistry.

    Science.gov (United States)

    New South Wales Dept. of Education, Sydney (Australia).

    As one in a series of test item collections developed by the Assessment and Evaluation Unit of the Directorate of Studies, items are made available to teachers for the construction of unit tests or term examinations or as a basis for class discussion. Each collection was reviewed for content validity and reliability. The test items meet syllabus…

  2. Characterization of the complete mitochondrial genome of Ortleppascaris sinensis (Nematoda: Heterocheilidae) and comparative mitogenomic analysis of eighteen Ascaridida nematodes.

    Science.gov (United States)

    Zhao, J H; Tu, G J; Wu, X B; Li, C P

    2018-05-01

    Ortleppascaris sinensis (Nematoda: Ascaridida) is a dominant intestinal nematode of the captive Chinese alligator. However, the epidemiology, molecular ecology and population genetics of this parasite remain largely unexplored. In this study, the complete mitochondrial (mt) genome sequence of O. sinensis was first determined using a polymerase chain reaction (PCR)-based primer-walking strategy, and this is also the first sequencing of the complete mitochondrial genome of a member of the genus Ortleppascaris. The circular mitochondrial genome (13,828 bp) of O. sinensis contained 12 protein-coding, 22 transfer RNA and 2 ribosomal RNA genes, but lacked the ATP synthetase subunit 8 gene. Finally, phylogenetic analysis of mtDNAs indicated that the genus Ortleppascaris should be attributed to the family Heterocheilidae. It is necessary to sequence more mtNDAs of Ortleppascaris nematodes in the future to test and confirm our conclusion. The complete mitochondrial genome sequence of O. sinensis reported here should contribute to molecular diagnosis, epidemiological investigations and ecological studies of O. sinensis and other related Ascaridida nematodes.

  3. Genotypic and environmental effects on cottonseed oil, nitrogen, and gossypol contents in eighteen years Regional High Quality tests

    Science.gov (United States)

    Determination of environmental influence on seed traits is critical for genetic improvement of seed quality in Upland cotton (Gossypium hirsutum L.). The objective of this study was to analyze the relative contribution of environment and genotype (G) for seed oil, nitrogen (N), and gossypol content...

  4. Intravitreal bevacizumab for macular edema due to proton beam radiotherapy: Favorable results shown after eighteen months follow-up

    Directory of Open Access Journals (Sweden)

    Eleni Loukianou

    2010-05-01

    Full Text Available Eleni Loukianou, Dimitrios Brouzas, Eleni Georgopoulou, Chrysanthi Koutsandrea, Michael ApostolopoulosEye Department, University of Athens, Athens, GreecePurpose: To evaluate the safety and efficacy of intravitreal injections of bevacizumab (Avastin® as a treatment option for radiation maculopathy secondary to proton beam radiotherapy for choroidal melanoma.Case: A 61-year-old woman presented with a gradual decrease in left eye visual acuity (VA 29 months after proton beam radiotherapy for choroidal melanoma. On presentation, her best-corrected VA (BCVA was 2/10 in the left eye and the intraocular pressure was 15 mmHg. Fundoscopy revealed cystoid macular edema, intraretinal hemorrhages, epiretinal membrane in the posterior pole, and residual tumor scar with exudative retinal detachment and hard exudates in the periphery of the superotemporal quadrant. A treatment with intravitreal injections of bevacizumab (Avastin® was recommended. The injections were performed on a six-weekly basis.Results: The central retinal thickness prior to the treatment was 458 μm. After the first intravitreal injection of bevacizumab, the retinal thickness at the centre of the fovea was reduced to 322 μm. After the third injection, the central retinal thickness was 359 μm and 18 months after presentation, it reduced to 334 μm. The BCVA increased to 3/10 after the intravitreal injections of bevacizumab and remained stable during the follow-up period. The intraocular pressure was within normal range during the follow-up period.Conclusion: Bevacizumab should be regarded as a treatment option for macular edema due to proton beam radiotherapy for choroidal melanoma. By reducing the central retinal thickness, intravitreal bevacizumab can improve VA or ameliorate further decline caused by radiation maculopathy.Keywords: bevacizumab (Avastin®, choroidal melanoma, macular edema, radiation retinopathy

  5. A Study to Determine the Current Level of Implementation of Eighteen Basic Middle School Principles in the State of Missouri.

    Science.gov (United States)

    Beckman, Vernal G.

    The current level of implementation of 18 basic middle school principles in the 147 Missouri schools that met the definition of middle schools is the focus of this study. Questionnaire responses were received from 101 of the schools' administrators. Mean scores, standard deviations, and mean percentages of the maximum possible scores yielded by…

  6. THE PENALIZED OPTIMAL EXPERIMENTAL DESIGN: THE PRECISE ESTIMATION OF AN INTERACTION THRESHOLD IN A MIXTURE OF EIGHTEEN POLYHALOGENATED AROMATIC HYDROCARBONS.

    Science.gov (United States)

    Crofton et al. (EHP, 2005) conducted a study of 18 polyhalogenated aromatic hydrocarbons (PHAHs) on serum total thyroxine (T4). Young female Long-Evans rats were dosed with the 18 single agents or a fixed-ratio mixture, and serum total T4 was measured via radioimmunoassay. The i...

  7. Macropolyhedral boron-containing cluster chemistry [S2B16H17](-). A new eighteen-vertex thiaborane anion

    Czech Academy of Sciences Publication Activity Database

    Carr, MJ.; Clegg, W.; Kennedy, J.D.; Londesborough, Michael Geoffrey Stephen; Kilner, C. A.

    2010-01-01

    Roč. 75, č. 8 (2010), s. 807-812 ISSN 0010-0765 Institutional research plan: CEZ:AV0Z40320502 Keywords : borane cluster * thiaborane * macropolyhedral Subject RIV: CA - Inorganic Chemistry Impact factor: 0.853, year: 2010

  8. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months

    NARCIS (Netherlands)

    van Goor, Saskia A.; Dijck-Brouwer, D. A. Janneke; Erwich, Jan Jaap H. M.; Schaafsma, Anne; Hadders-Algra, Mijna

    2011-01-01

    Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for neurodevelopment. The effects of DHA (220 mg/day, n=41), DHA+AA (220 mg/day, n=39) or placebo (n=34) during pregnancy and lactation on neurodevelopment at 18 months, and the relations between umbilical cord DHA, AA and Mead acid

  9. Household catastrophic health expenditures: a comparative analysis of twelve Latin American and Caribbean Countries Gastos catastróficos en salud de los hogares: un análisis comparativo de doce países en América Latina y el Caribe

    Directory of Open Access Journals (Sweden)

    Felicia Marie Knaul

    2011-01-01

    Full Text Available OBJECTIVE: Compare patterns of catastrophic health expenditures in 12 countries in Latin America and the Caribbean. MATERIAL AND METHODS: Prevalence of catastrophic expenses was estimated uniformly at the household level using household surveys. Two types of prevalence indicators were used based on out-of-pocket health expense: a relative to an international poverty line, and b relative to the household's ability to pay net of their food basket. Ratios of catastrophic expenditures were estimated across subgroups defined by economic and social variables. RESULTS: The percent of households with catastrophic health expenditures ranged from 1 to 25% in the twelve countries. In general, rural residence, lowest quintile of income, presence of older adults, and lack of health insurance in the household are associated with higher propensity of catastrophic health expenditures. However, there is vast heterogeneity by country. CONCLUSIONS: Cross national studies may serve to examine how health systems contribute to the social protection of Latin American households.OBJETIVO: Comparar los patrones de gastos catastróficos en salud en 12 países de América Latina y el Caribe. MATERIAL Y MÉTODOS: Se estimó la prevalencia de gastos catastróficos de manera uniforme para doce países usando encuestas de hogares. Se emplearon dos tipos de indicadores para medir la prevalencia basados en el gasto de bolsillo en salud: a en relación con una línea de pobreza internacional; y b en relación con la capacidad de pago del hogar en términos de su propia canasta alimentaria. Se estimaron razones para comparar el nivel de gastos catastróficos entre subgrupos poblacionales definidos por variables económicas y sociales. RESULTADOS: El porcentaje de hogares con gastos catastróficos variaron de 1 a 25% en los 12 países. En general, la residencia rural, el bajo nivel de ingresos, la presencia de adultos mayores, y la carencia de aseguramiento en salud de los hogares

  10. Antioxidant Capacity and Total Phenolic Compounds of Twelve Selected Potato Landrace Clones Grown in Southern Chile Capacidad Antioxidante y Compuestos Fenólicos totales de una Selección de Doce Variedades Tradicionales de Papa Cultivadas en la Región Sur de Chile

    Directory of Open Access Journals (Sweden)

    Kong Ah-Hen

    2012-03-01

    Full Text Available Colored potatoes (Solanum tuberosum L. provide a natural source of phytochemicals that help reduce the risk of diseases. However, there is a lack of information on the degree of variation of the antioxidant activity and polyphenolic contents of these native potatoes. Thus, the antioxidant activity (AA and total phenolic content (TPC of native Chilean potatoes were determined. Twelve potato landrace clones collected from established cultivations on Chiloe Island and Valdivia were selected. Total phenolic content and AA were compared with two commercial varieties, Shepody and Desirée. Total phenolic content was determined by the Folin-Ciocalteu method, and β-carotene bleaching was used to compare AA. The TPC varied in the peeled potato samples from 191 to 1864 mg 100 g-1 DM meanwhile these parameters varied from 345 to 2852 mg 100 g-1 DM in unpeeled samples. Antioxidant activity was higher in unpeeled potatoes, and was the highest in the unpeeled NG-6 or 'Bruja' native potato. The commercial var. Shepody showed pro-oxidant activity and had a relatively lower TPC. Results also indicated a higher concentration of total phenolics in the periderm of the colored native Chilean potatoes.Las papas (Solanum tuberosum L. coloreadas son una fuent natural de fitoquímicos que ayudan a reducir el riesgo de enfermedades. Sin embargo, existe una falta de información sobre el grado de variación de la actividad antioxidante y el contenido de polifenoles en estas papas nativas. Es así como la actividad antioxidante (AA y contenido de fenoles totales (TPC se determinaron en papas nativas chilenas. Doce genotipos de papa recogidos de cultivos establecidos en la Isla de Chiloé y en Valdivia fueron seleccionados, y se compararon TPC y AA con dos variedades comerciales, Shepody y Desirée. El TPC se determinó por el método de Folin-Ciocalteu, y el blanqueamiento de p-caroteno se utilizó para comparar la AA. El TPC varió en las muestras de papas sin piel desde

  11. O uso da toxina botulínica no tratamento da distonia laríngea (disfonia espasmódica: estudo preliminar com doze pacientes Use of botulinum toxin in the treatment of laryngeal dystonia (spasmodic dysphonia: preliminary study of twelve patients

    Directory of Open Access Journals (Sweden)

    Hélio A. G. Teive

    2001-03-01

    Full Text Available A distonia laríngea (disfonia espasmódica é distúrbio do movimento caracterizado por contrações involuntárias da musculatura laríngea envolvida no processo de vocalização. A utilização da toxina botulínica no tratamento da distonia laríngea trouxe consideráveis benefícios clínicos. Descrevemos os resultados preliminares do uso terapêutico da toxina botulínica no tratamento da distonia laríngea em 12 pacientes. Após investigação clínica, os pacientes foram submetidos a videolaringoestroboscopia para confirmação diagnóstica e as injeções de toxina botulínica foram realizadas através de punção da membrana cricotireóidea em direção ao músculo tireoaritenóideo, com uso de eletromiografia. A maioria dos pacientes submetidos ao tratamento com toxina botulínica apresentou melhora significativa da distonia laríngea (83% dos casos, com duração média do efeito de quatro meses, sem efeitos colaterais significativos.Laryngeal dystonia (spasmodic dysphonia is a movement disorder characterized by involuntary contractions of laryngeal muscles involved with vocalization. The introduction of botulinum toxin in the treatment of laryngeal dystonia had a major clinical impact due to the striking improvement of symptoms. We report the preliminary results of therapeutical use of botulinum toxin in the treatment of twelve patients with laryngeal dystonia. After an extensive clinical evaluation, the patients underwent a videostroboscopic exam for diagnostic confirmation. Botulinum toxin was injected in the cricothyreoid membrane, directed towards the thyreoaritenoid muscle, with the aid of eletromyography needles. Most of patients who underwent botulinum toxin injection had a significant improvement of their symptoms (83%, with effects lasting for four months in average and without important side effects.

  12. Radionuclide content of an exhumed canyon vessel and neighboring soil

    International Nuclear Information System (INIS)

    Holcomb, H.P.

    1976-11-01

    The long-term hazard potential associated with burial of process equipment from radiochemical separations plants is being evaluated. As part of this evaluation, a feed adjustment tank was exhumed eighteen years after burial. The tank had been in service in the fuel reprocessing plant for twenty-nine months before it was retired. Assay of the exhumed tank indicated that 7 mg (0.4 mCi) of 239 Pu and 1 mCi of 137 Cs remained on its surfaces; 1.1 mg (0.07 mCi) 239 Pu, 0.4 mCi 137 Cs, and 3.5 mCi 90 Sr were found in neighboring soil. The vessel and surrounding soil have met the present guidelines (less than or equal to 10 nCi/g) of the U. S. Energy Research and Development Administration (ERDA) for nonretrievable waste

  13. On the blood-brain barrier to peptides: [3H]gonadotropin-releasing hormone accumulation by eighteen regions of the rat brain and by anterior pituitary

    International Nuclear Information System (INIS)

    Ermisch, A.; Ruehle, H.J.; Klauschenz, E.; Kretzschmar, R.

    1984-01-01

    After intracarotid injection of [ 3 H]gonadotropin-releasing hormone ([ 3 H]GnRH) the mean accumulation of radioactivity per unit wet weight of 18 brain samples investigated and the anterior pituitary was 0.38 +- 0.11% g -1 of the injected tracer dose. This indicates a low but measurable brain uptake of the peptide. The brain uptake of [ 3 H]GnRH in blood-brain barrier (BBB)-protected regions is 5% of that of separately investigated [ 3 H]OH. In BBB-free regions the accumulation of radioactivity was more than 25-fold higher than in BBB-protected regions. The accumulation of [ 3 H]GnRH among regions with BBB varies less than among regions with leaky endothelia. The data presented for [ 3 H]GnRH are similar to those for other peptides so far investigated. (author)

  14. PREFACE: The First Eighteen Years of Reverse Monte Carlo Modelling, a workshop held in Budapest, Hungary (28 30th September 2006)

    Science.gov (United States)

    Keen, David A.; Pusztai, László

    2007-08-01

    This Special Issue contains a collection of papers reflecting the content of the third workshop on reverse Monte Carlo (RMC) methods, held in a hotel on hills overlooking Budapest at the end of September 2006. Over forty participants gathered to hear talks and discuss a broad range of science based on the RMC technique in very convivial surroundings. Reverse Monte Carlo modelling is a method for producing three-dimensional disordered structural models in quantitative agreement with experimental data. The method was developed in the late 1980s and has since achieved wide acceptance within the scientific community [1]. It is particularly suitable for studies of the structures of liquid and amorphous materials, although it may also be applied effectively to the structural analysis of disordered crystalline systems. Since the previous RMC workshop in 2003 [2] there have been several developments in the technique, particularly as applied to crystals, and in the range of its application, most noticeable being the routine modelling of multiple data sets for a given problem; the latter growing through the increasing quality and availability of x-ray total scattering data from synchrotron x-ray sources. The RMC workshop was particularly beneficial, providing a forum for those workers in the field to take stock of past achievements and to look forward to future developments. It is our hope that the collection of papers within this Special Issue will also communicate this to the wider scientific community, providing a balance between papers that have more of an introductory review flavour and those that concentrate on current state of the art research opportunities using the RMC method. Furthermore, by including a small number of papers from colleagues working on similar disordered problems with complementary analysis techniques, we hope that the RMC method may be placed in a broader scientific context. The papers within this special issue have been arranged into four groups: those concerning liquids (1-8), amorphous (9-13) and crystalline materials (14-17) and those of a more general nature (18-23). Within these groupings, there are descriptions of RMCProfile (18) and RMCt (23), programs which use RMC methods to analyse total scattering from crystalline materials and to model inelastic neutron scattering data, respectively. There is also work using the related EPSR (6) and PDFfit (19) techniques, developments of the RMC method for analysis of single crystal electron diffraction (16) or polarised neutron diffraction (7), and examples of simultaneous RMC modelling of neutron and x-ray total scattering and XAS data (13, 10) . We are very grateful to IoP Publishing for their willingness to publish the proceedings of this meeting in a Special Issue of Journal of Physics: Condensed Matter. References [1] McGreevy R L 2001 J. Phys.: Cond. Matter 13 R877 [2] RMC-2 Workshop Proceedings 2005 J. Phys.: Cond. Matter 17 S1-S174

  15. Increase in white cell and neutrophil counts during the first eighteen weeks of treatment with clozapine in patients admitted to a long-term psychiatric care inpatient unit.

    Science.gov (United States)

    Capllonch, Adrián; de Pablo, Silvia; de la Torre, Alberto; Morales, Ignacio

    Clozapine is an antipsychotic drug that has shown to be more effective than other antipsychotics in the treatment of schizophrenia, but its use is limited due to its side effects, particularly by the risk of causing agranulocytosis. A study was made on the variations in white cell and neutrophil counts in patients treated with clozapine in a Long-term Psychiatric Unit. A retrospective observational study was conducted with a sample of women of our long-term psychiatric care unit who had been treated with clozapine. A study was made on the variations in white cell and neutrophil counts during the first 18 weeks of treatment, as well as the onset of leukopenia, neutropenia, agranulocytosis, and the influence of concomitant drugs. The study included 55 patients on treatment with clozapine. The incidence rate of neutropenia was 1.82% (95% CI; 0.05-10.13). The incidence rate of leukopenia and agranulocytosis was 0%. An increase in white cell and neutrophil counts from baseline to week 3-4 was observed. Only small variations were observed after this time, but the counts remained higher than the initial values. These changes were statistically significant in the white cell count: One-way repeated ANOVA with Greenhouse-Geisser correction F (11.47, 37) = 2.114 (P= .011); and in neutrophils: One-way repeated ANOVA with Greenhouse-Geisser correction F (10.3, 37)=3.312 (P=.0002), and MANOVA F (18, 37)=2.693 (P=.005), ŋ 2 P =0.567. The influence of concomitant drugs (lithium, valproic and biperiden) was not significant on the overall increase found in white cells or neutrophils (MANOVA). Copyright © 2016 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Consumo alimentar de crianças de 6 a 18 meses em creches Six to eighteen-month-old children's food intake in day-care centers

    Directory of Open Access Journals (Sweden)

    Mônica Glória Neumann Spinelli

    2003-12-01

    Full Text Available OBJETIVO: Verificar o consumo alimentar de crianças entre 6 e 18 meses e avaliar a adequação de nutrientes. MÉTODOS: O estudo foi realizado com 106 crianças em creches do Município de São Paulo. Para verificar o consumo alimentar utilizou-se o método de pesagem direta, durante cinco dias. Para análise dos macro e micronutrientes utilizaram-se as referências Organización Mundial de la Salud 1985 e Dietary Reference Intakes 1997, e para fibras adotou-se a recomendação da American Academy of Pediatrics 1993. RESULTADOS: O estudo revelou oferta insuficiente de energia, ferro, cálcio, vitamina A e fibras. A proteína e a vitamina C excederam as recomendações. CONCLUSÃO: Nos moldes do programa atual, é necessário que a criança receba, no domicílio, uma refeição láctea e outra salgada para complementar principalmente cálcio, energia, ferro e fibras.OBJECTIVE: To verify the food intake of children from 6 to 18 months old and to evaluate nutrient adequacy. METHODS: This study was carried out with 106 children, in day-care centers from the city of São Paulo. Food intake was evaluated through food weighing during five days. The Organización Mundial de la Salud, 1985, Dietary Reference Intakes, 1997 and American Academy of Pediatrics, 1993 were used as references for the analysis of macronutrients, micronutrientes and fibers, respectively. RESULTS: The study revealed insufficient offering of energy, iron, calcium, vitamin A and fiber. Protein and vitamin C were over the recommended amounts. CONCLUSION: The children must receive one milky and one salty meal at home in order to complement food given at centers, mainly regarding, calcium, iron, energy and fiber.

  17. Eighteen-month follow-up of a play-based intervention to improve the social play skills of children with attention deficit hyperactivity disorder.

    Science.gov (United States)

    Wilkes-Gillan, Sarah; Bundy, Anita; Cordier, Reinie; Lincoln, Michelle

    2014-10-01

    There is a well-documented need for interventions to successfully address the social difficulties of children with attention deficit hyperactivity disorder. This study aimed to further the development of a previously conducted pilot of a play-based intervention. To achieve this, children's social play outcomes pre-post and 18-month following the intervention were examined by raters unaware of the study's purpose. Additionally, parents' experiences of the intervention were explored. Participants included five children with attention deficit hyperactivity disorder who had participated in a play-based intervention and their typically developing playmates; parents of children with attention deficit hyperactivity disorder also participated. Children and their playmates attended an 18-month follow-up play session and parents participated in semi-structured interviews. The Test of Playfulness was used to measure children's play outcomes in the context of social play with a peer, pre-post and 18-months following the intervention. Wilcoxon signed-ranks (Z) and Cohen's-d were used to measure effect. Thematic analysis was used to analyse reoccurring themes from parents' interviews. Children's social play outcomes improved pre-post intervention (Z = 2.02; P = 0.04; d = 1.6) and were maintained 18-month post intervention (Z = 0.14; P = 0.89; d = -0.4). Core themes included: the intervention as an enjoyable experience, a common language for talking about play/social interactions, an observable change in children's skills, transference of skills and the need for support to refresh learnt lessons over time. The intervention demonstrated preliminary and long-term efficacy in developing the social play skills of children with attention deficit hyperactivity disorder. Further research is required to optimise intervention feasibility and parent involvement prior to conducting a large-scale research. © 2014 Occupational Therapy Australia.

  18. Value of children and fertility: Results from a cross-cultural comparative survey in eighteen areas in Asia, Africa, Europe and America.

    Science.gov (United States)

    Nauck, Bernhard

    2014-09-01

    For explaining cross-cultural differences in fertility behavior, this paper conjoins three complementary approaches: the 'demand'-based economic theory of fertility (ETF), a revised version of the 'supply'-based 'value-of-children' (VOC)-approach as a special theory of the general social theory of social production functions and the framing theory of variable rationality. A comprehensive model is specified that encompasses the variable efficiency of having children for the optimization of physical well-being and of social esteem of (potential) parents; it also accounts for the variable rationality of fertility decisions. The model is tested with a data set that comprises information on VOC and fertility of women within the social settings of 18 areas (Peoples Republic of China, North and South India, Indonesia, Palestine, Israel, Turkey, Ghana, South Africa, East and West Germany, the Czech Republic, France, Russia, Poland, Estonia, the United States and Jamaica). Latent class analysis is used to establish a measurement model for the costs and benefits of children and to analyze area differences by a two-level multinomial-model. Two-level Cox-regressions are used to estimate the effects of perceived costs and benefits of children, individual resources and context opportunities, with births of different parity as dependents. This simultaneous test in a cross-cultural context goes beyond the current state of fertility research and provides evidence about the cross-cultural validity of the model, the systematic effects of VOC on fertility and the changing rationality of fertility decisions during demographic transition and socio-economic change. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting.

    Science.gov (United States)

    Lackovic, Kurt; Lessene, Guillaume; Falk, Hendrik; Leuchowius, Karl-Johan; Baell, Jonathan; Street, Ian

    2014-03-01

    The Walter and Eliza Hall Institute of Medical Research (WEHI) is Australia's longest serving medical research institute. WEHI's High Throughput Screening (HTS) Facility was established in 2003 with $5 million of infrastructure funds invested by WEHI, and the Victorian State Government's Strategic Technology Initiative through Bio21 Australia Ltd. The Facility was Australia's first truly academic HTS facility and was one of only a handful operating in publicly funded institutions worldwide at that time. The objectives were to provide access to enabling HTS technologies, such as assay design, liquid handling automation, compound libraries and expertise to promote translation of basic research in a national setting that has a relatively young biotech sector and does not have a big Pharma research presence. Ten years on and the WEHI HTS Facility has participated in over 92 collaborative projects, generated over 18 million data points, and most importantly, projects that began in the Facility have been commercialized successfully (due to strong ties with Business Development and emphasis on intellectual property management) and now have molecules progressing in clinical trials.

  20. An assessment of the quality of care for children in eighteen randomly selected district and sub-district hospitals in Bangladesh

    Directory of Open Access Journals (Sweden)

    Hoque Dewan ME

    2012-12-01

    Full Text Available Abstract Background Quality hospital care is important in ensuring that the needs of severely ill children are met to avert child mortality. However, the quality of hospital care for children in developing countries has often been found poor. As the first step of a country road map for improving hospital care for children, we assessed the baseline situation with respect to the quality of care provided to children under-five years age in district and sub-district level hospitals in Bangladesh. Methods Using adapted World Health Organization (WHO hospital assessment tools and standards, an assessment of 18 randomly selected district (n=6 and sub-district (n=12 hospitals was undertaken. Teams of trained assessors used direct case observation, record review, interviews, and Management Information System (MIS data to assess the quality of clinical case management and monitoring; infrastructure, processes and hospital administration; essential hospital and laboratory supports, drugs and equipment. Results Findings demonstrate that the overall quality of care provided in these hospitals was poor. No hospital had a functioning triage system to prioritise those children most in need of immediate care. Laboratory supports and essential equipment were deficient. Only one hospital had all of the essential drugs for paediatric care. Less than a third of hospitals had a back-up power supply, and just under half had functioning arrangements for safe-drinking water. Clinical case management was found to be sub-optimal for prevalent illnesses, as was the quality of neonatal care. Conclusion Action is needed to improve the quality of paediatric care in hospital settings in Bangladesh, with a particular need to invest in improving newborn care.

  1. In a world without faith and dominated by ambition: Representations of Brazil and the Portuguese in the First Half of the Eighteen Century European Travel Literature

    Directory of Open Access Journals (Sweden)

    Domingues, Ângela

    2012-12-01

    Full Text Available As part of a reflection on Atlantic history, I intend to reread the travel literature written by Europeans who stayed briefly at the Brazilian shore, so as to learn about the Portuguese empire -and particularly Brazil- from the inside and understand how the Portuguese and Luso-Brazilians of the colony were perceived. Travelers registered their impressions based on their own principles, and in some cases exaggerated the cultural differences they observed. This rereading makes it possible to evaluate the differences between a Europe constituted by nations, kingdoms and empires, and Mediterranean Europe. The travel literature, which did not have Brazil as final destination, could have disproportionate and unsuspected repercussions. The accounts showed Portugal and its colonies as similar to Spain and very different from the rest of Europe, at a period of affirmation of the national States and aggressive imperial external policies aimed at the South Atlantic.Desde una reflexión en torno a la historia atlántica, pretendo releer la literatura de viajes escrita por europeos que permanecieron brevemente en el litoral brasileño, para así conocer el Imperio Portugués -y muy particularmente Brasil- desde adentro y comprender cómo eran percibidos los portugueses y luso-brasileños de la colonia. Los viajeros registraban sus impresiones a partir de sus propios principios, exagerando en algunos casos las diferencias culturales observadas. Esta relectura permite evaluar las diferencias entre una Europa constituida por naciones, reinos e imperios; y la Europa Mediterránea. La literatura de viajes, cuyo destino final no era Brasil, podía tener repercusiones desproporcionadas e insospechadas. Los relatos mostraban a Portugal y sus colonias similar a España y muy diferente del resto de Europa, en un período de afirmación de los estados nacionales y agresivas políticas externas imperialista que apuntaban al Atlántico Sur.

  2. Survey on the use of psychotropic drugs by twelve military police units in the municipalities of Goiânia and Aparecida de Goiânia, state of Goiás, Brazil Pesquisa sobre uso de drogas psicotrópicas em 12 unidades da Polícia Militar nos municípios de Goiânia e Aparecida de Goiânia, Estado de Goiás, Brasil

    Directory of Open Access Journals (Sweden)

    Sérgio Henrique Nascente Costa

    2010-12-01

    Full Text Available OBJECTIVE: To determine the prevalence of psychotropic drug use among military police officers in the state of Goiás, Brazil. METHOD: Study carried out at twelve military police units located in the municipalities of Goiânia and Aparecida de Goiânia between March to October 2008. Volunteers (n = 221 were interviewed about drug use using a questionnaire especially designed by the Centro Brasileiro de Informações sobre Drogas Psicotrópicas (CEBRID. Descriptive statistics was used to determine the prevalence of licit and illicit drug use in the study sample. RESULTS: The frequency of use was divided into: 1 lifetime use: tobacco - 39.9%, alcohol - 87.8%, cannabis - 8.1%, cocaine - 1.8%, stimulants - 7.2%, solvents - 10.0%, sedatives, anxiolytics, antidepressants - 6.8%, LSD - 0.5%, Bentyl® - 0.5%, anabolic steroids - 5.4%; 2 use in the previous year: tobacco - 15.4%, alcohol - 72.9%, stimulants - 6.3%, solvents - 0.5%, sedatives, anxiolytics, antidepressants - 3.7%; 3 use in the previous 30 days: tobacco - 14.5%, alcohol - 57.5%, stimulants - 5.0%, solvents - 0.5, sedatives, anxiolytics, antidepressants - 3.7%. CONCLUSION: The high prevalence rate of psychotropic drug use found amoung military police officers in two cities of the state of Goiás in Brazil can be considered an important factor with potential influence on job activities.OBJETIVO: Verificar a prevalência do uso de drogas psicotrópicas por membros da Polícia Militar no Estado de Goiás, Brasil. MÉTODO: Estudo realizado de março a outubro de 2008 em 12 unidades da Polícia Militar dos municípios de Goiânia e Aparecida de Goiânia. Participantes voluntários (n = 221 foram entrevistados sobre uso de drogas utilizando-se questionário desenvolvido pelo Centro Brasileiro de Informações sobre Drogas Psicotrópicas (CEBRID. A estatística descritiva foi usada para determinar a prevalência de uso de drogas lícitas e ilícitas na amostra estudada. RESULTADOS: A frequência de

  3. Creating Space for God in the Lives of Millennials by Leveraging Technology to Practice a Spiritual Discipline Modeled by Christ

    Science.gov (United States)

    St. John, Kelvin Wesley

    2013-01-01

    Today's Millennials, the first generation to reach their majority in this millennium, often compartmentalize their faith lives from their social and work lives. MidAmerica Nazarene University (MNU) offers a course in Spiritual Formation once each spring. The enrollment for this elective course ranges from twelve to eighteen students per class.…

  4. A contrastive study of the phonology of Igbo and Yoruba | Eme ...

    African Journals Online (AJOL)

    Igbo is made up of twentyeight consonants and eight oral vowels, while Yoruba has eighteen consonants, and twelve vowels comprising seven oral vowels and five nasal vowels. The contrastive analysis carried out evinced that there are some sounds in Igbo which are not present in Yoruba; also some sounds in Yoruba ...

  5. Complications and renal functional deterioration in patients with co ...

    African Journals Online (AJOL)

    E. Sharma

    2016-07-26

    Jul 26, 2016 ... (CCS) [7] with scores varying from 2 to 7. Eleven patients had CCS of 2, twelve patients had CCS of 3, nineteen patients had CCS of. 4, eighteen patients had CCS of 5, seven patients had CCS of 6 and one patient had CCS of 7 (Chart 1). Partial nephrectomy was done laparoscopically, hilar clamping.

  6. 77 FR 50742 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving a Proposed Rule...

    Science.gov (United States)

    2012-08-22

    ... multiples of six (e.g., six, twelve, eighteen or twenty-four cross connects). The Exchange proposes to... monthly to furnish and install one cross connect between cabinets. For a bundle of six cross connects, the... differentiation among Users regarding the fees charged for a particular product, service or piece of equipment. In...

  7. 77 FR 50733 - Self-Regulatory Organizations; NYSE MKT LLC; Order Approving a Proposed Rule Change Amending the...

    Science.gov (United States)

    2012-08-22

    ... connects in multiples of six (e.g., six, twelve, eighteen or twenty-four cross connects). The Exchange... charge $500 monthly to furnish and install one cross connect between cabinets. For a bundle of six cross... Users regarding the fees charged for a particular product, service or piece of equipment. In light of...

  8. 77 FR 50743 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Approving a Proposed Rule Change Amending...

    Science.gov (United States)

    2012-08-22

    ... multiples of six (e.g., six, twelve, eighteen or twenty-four cross connects). The Exchange proposes to... monthly to furnish and install one cross connect between cabinets. For a bundle of six cross connects, the... fees charged for a particular product, service or piece of equipment. In light of the Exchange's...

  9. 77 FR 50734 - Self-Regulatory Organizations; NYSE MKT LLC; Order Approving a Proposed Rule Change Amending the...

    Science.gov (United States)

    2012-08-22

    ... cross connect or several cross connects in multiples of six (e.g., six, twelve, eighteen or twenty-four.... For a bundle of six cross connects, the monthly charge would be $1,500; 12 cross connects would be $2... differentiation among Users regarding the fees charged for a particular product, service or piece of equipment. In...

  10. Efficiency of three reproductive hormones in artificial propagation of ...

    African Journals Online (AJOL)

    Efficiency of three reproductive hormones: ovaprim, ovulin and carp pituitary extract (C.P.E) in artificial propagation of Heterobranchus longifilis was investigated. Total of twelve broodstock fish, comprising nine females and three males at eighteen months of age were used. Females were divided into three groups.

  11. Birth, growth and progresses through the last twelve years of a regional scale landslide warning system

    Science.gov (United States)

    Fanti, Riccardo; Segoni, Samuele; Rosi, Ascanio; Lagomarsino, Daniela; Catani, Filippo

    2017-04-01

    SIGMA is a regional landslide warning system that operates in the Emilia Romagna region (Italy). In this work, we depict its birth and the continuous development process, still ongoing, after over a decade of operational employ. Traditionally, landslide rainfall thresholds are defined by the empirical correspondence between a rainfall database and a landslide database. However, in the early stages of the research, a complete catalogue of dated landslides was not available. Therefore, the prototypal version of SIGMA was based on rainfall thresholds defined by means of a statistical analysis performed over the rainfall time series. SIGMA was purposely designed to take into account both shallow and deep seated landslides and it was based on the hypothesis that anomalous or extreme values of accumulated rainfall are responsible for landslide triggering. The statistical distribution of the rainfall series was analyzed, and multiples of the standard deviation (σ) were used as thresholds to discriminate between ordinary and extraordinary rainfall events. In the warning system, the measured and the forecasted rainfall are compared with these thresholds. Since the response of slope stability to rainfall may be complex, SIGMA is based on a decision algorithm aimed at identifying short but exceptionally intense rainfalls and mild but exceptionally prolonged rains: while the former are commonly associated with shallow landslides, the latter are mainly associated with deep-seated landslides. In the first case, the rainfall threshold is defined by high σ values and short durations (i.e. a few days); in the second case, σ values are lower but the decision algorithm checks long durations (i.e. some months). The exact definition of "high" and "low" σ values and of "short" and "long" duration varied through time according as it was adjusted during the evolution of the model. Indeed, since 2005, a constant work was carried out to gather and organize newly available data (rainfall recordings and landslides occurred) and to use them to define more robust relationships between rainfalls and landslide triggering, with the final aim to increase the forecasting effectiveness of the warning system. The updated rainfall and landslide database were used to periodically perform a quantitative validation and to analyze the errors affecting the system forecasts. The errors characterization was used to implement a continuous process of updating and modification of SIGMA, that included: - Main model upgrades (generalization from a pilot test site to the whole Emilia Romagna region; calibration against well documented landslide events to define specific σ levels for each territorial units; definition of different alert levels according to the number of expected - Ordinary updates (periodically, the new landslide and rainfall data were used to re-calibrate the thresholds, taking into account a more robust sample). - Model tuning (set up of the optimal version of the decisional algorithm, including different definitions of "long" and "short" periods; selection of the optimal reference rain gauge for each Territorial Unit; modification of the boundaries of some territorial - Additional features (definition of a module that takes into account the effect of snow melt and snow accumulation; coupling with a landslide susceptibility model to improve the spatial accuracy of the model). - Various performance tests (including the comparison with alternate versions of SIGMA or with thresholds based on rainfall intensity and duration). This process has led to an evolution of the warning system and to a documented improvement of its forecasting effectiveness. Landslide forecasting at regional scale is a very complex task, but as time passes by and with the systematic gathering of new substantial data and the continuous progresses of research, uncertainties can be progressively reduced and a warning system can be set that increases its performances and reliability with time.

  12. Twelve cases of multiple myeloma in Nagasaki (especially seven atomic bombing casualty cases). [In Japanese

    Energy Technology Data Exchange (ETDEWEB)

    Ichimaru, M; Yasuhi, S; Ouchuru, S

    1963-12-01

    Since 1958, there have been 12 cases of multiple myeloma in Nagasaki, and among them were 7 cases representing atomic bombing casualties, with 3 cases being with 2 km distance from the hypocenter. The age of onset was between 51 and 69 years, and the sex ratio was 8:4, it occurring mostly in males. Symptoms were predominantly low back pain and chest pain caused by the bone changes in 8 cases. Two cases complained of general malaise and palpitation which resulted from anemia. One developed persistent epistaris, and another complained of diplopia caused by the paralysis of the oculomotor nerve. Peripheral blood in all cases showed anemia, 9 with hyperchromic and 3 with normochromic or hypochromic anemia. Low platelet counts were seen in 3 cases. All showed leukopenia. All cases showed typical ..gamma..-globulin change with a myeloma peak, and in 4 cases showed an increase of ..beta..-globulin. Bence-Jones proteinuria was present in 5 cases. Average course was 1 year 4 months. Among complications, myeloma nephrosis, aplastic anemia, and pneumonia were the most important ones.

  13. A Classification Scheme for Adult Education. Education Libraries Bulletin, Supplement Twelve.

    Science.gov (United States)

    Greaves, Monica A., Comp.

    This classification scheme, based on the 'facet formula' theory of Ranganathan, is designed primarily for the library of the National Institute of Adult Education in London, England. Kinds of persons being educated (educands), methods and problems of education, specific countries, specific organizations, and forms in which the information is…

  14. Effect of Verbal Feedback in Twelve Weeks Handball Training on Self-Efficacy and Life Satisfaction

    Science.gov (United States)

    Toros, Turhan

    2018-01-01

    The aim of this study was investigate the effect of verbal feedback on self-efficacy and life satisfaction. A total of 30 students as experimental group (n=15, mean age= 20.13±1.79) and control group (n=15, mean age=20.57±1.62) with similar characteristics were included in the study. Self-efficacy scale that originally developed by Riggs "et…

  15. Beta decay of twelve light neutron-rich isotopes from 17C to 40S

    International Nuclear Information System (INIS)

    Dufour, J.P.; Del Moral, R.; Fleury, A.; Hubert, F.; Jean, D.; Pravikoff, M.S.; Geissel, H.; Schmidt, K.H.

    1986-07-01

    The results reported here have been obtained with an 40 Argon beam on a Be target. The separated nuclei were implanted in a catcher foil placed in between a thin scintillator detecting the betas and a high volume Ge detector; only gammas in coincidence with betas were recorded. Results for the gamma energies and the half-lives of the observed isotopes are given

  16. Twelve tips for teaching in a provincially distributed medical education program.

    Science.gov (United States)

    Wong, Roger Y; Chen, Luke; Dhadwal, Gurbir; Fok, Mark C; Harder, Ken; Huynh, Hanh; Lunge, Ryan; Mackenzie, Mark; Mckinney, James; Ovalle, William; Rauniyar, Pooja; Tse, Luke; Villanyi, Diane

    2012-01-01

    As distributed undergraduate and postgraduate medical education becomes more common, the challenges with the teaching and learning process also increase. To collaboratively engage front line teachers in improving teaching in a distributed medical program. We recently conducted a contest on teaching tips in a provincially distributed medical education program and received entries from faculty and resident teachers. Tips that are helpful for teaching around clinical cases at distributed teaching sites include: ask "what if" questions to maximize clinical teaching opportunities, try the 5-min short snapper, multitask to allow direct observation, create dedicated time for feedback, there are really no stupid questions, and work with heterogeneous group of learners. Tips that are helpful for multi-site classroom teaching include: promote teacher-learner connectivity, optimize the long distance working relationship, use the reality television show model to maximize retention and captivate learners, include less teaching content if possible, tell learners what you are teaching and make it relevant and turn on the technology tap to fill the knowledge gap. Overall, the above-mentioned tips offered by front line teachers can be helpful in distributed medical education.

  17. Student radiographers' attitudes towards the older patient: Six and twelve months post intervention

    International Nuclear Information System (INIS)

    Kada, S.; Booth, L.

    2016-01-01

    Purpose: To design and evaluate the effects of an educational intervention on Norwegian student radiographer attitudes towards older people. Design: A longitudinal study design, using pre-test and post-test data was used to determine student attitudes to older people across their educational tenure. Attitudes were measured using Kogan's attitudes towards older people scale. This paper, the second in the series, reports on the changes in student radiographer attitudes, post an educational intervention and post their first experience of clinical placement. Results: Although students initially demonstrated significantly improved attitudes towards older people (p = 0.01), this significance was not noted at 6 months and 12 months post intervention. In fact average scores reduced to an almost identical level to those found pre-intervention Conclusion: Whereas an educational intervention can have an initial positive effect on student attitudes towards older people, the experience of clinical placement reduces these initial effects. - Highlights: • Reports the effects of an intervention to improve attitudes to older people. • Pre-intervention students had generally positive attitudes to older people. • Post-intervention attitudes were significantly more positive. • At 6 months and 12 months post-intervention mean positive scores were reduced. • Some questions score significantly more negatively than others.

  18. Perceptual effects of linguistic category priming: the Stapel and Semin (2007) paradigm revisited in twelve experiments.

    Science.gov (United States)

    IJzerman, Hans; Regenberg, Nina F E; Saddlemyer, Justin; Koole, Sander L

    2015-05-01

    Linguistic category priming is a novel paradigm to examine automatic influences of language on cognition (Semin, 2008). An initial article reported that priming abstract linguistic categories (adjectives) led to more global perceptual processing, whereas priming concrete linguistic categories (verbs) led to more local perceptual processing (Stapel & Semin, 2007). However, this report was compromised by data fabrication by the first author, so that it remains unclear whether or not linguistic category priming influences perceptual processing. To fill this gap in the literature, the present article reports 12 studies among Dutch and US samples examining the perceptual effects of linguistic category priming. The results yielded no evidence of linguistic category priming effects. These findings are discussed in relation to other research showing cultural variations in linguistic category priming effects (IJzerman, Saddlemyer, & Koole, 2014). The authors conclude by highlighting the importance of conducting and publishing replication research for achieving scientific progress. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  19. False memories and lexical decision: even twelve primes do not cause long-term semantic priming.

    Science.gov (United States)

    Zeelenberg, René; Pecher, Diane

    2002-03-01

    Semantic priming effects are usually obtained only if the prime is presented shortly before the target stimulus. Recent evidence obtained with the so-called false memory paradigm suggests, however, that in both explicit and implicit memory tasks semantic relations between words can result in long-lasting effects when multiple 'primes' are presented. The aim of the present study was to investigate whether these effects would generalize to lexical decision. In four experiments we showed that even as many as 12 primes do not cause long-term semantic priming. In all experiments, however, a repetition priming effect was obtained. The present results are consistent with a number of other results showing that semantic information plays a minimal role in long-term priming in visual word recognition.

  20. Conformational analysis of six- and twelve-membered ring compounds by molecular dynamics

    DEFF Research Database (Denmark)

    Christensen, I T; Jørgensen, Flemming Steen

    1997-01-01

    . A series of methyl-substituted 1,3-dioxanes were investigated at 1000 K, and the number of chair-chair interconversions could be quantitatively correlated to the experimentally determined ring inversion barrier. Similarly, the distribution of sampled minimum-energy conformations correlated with the energy......-derived Boltzmann distribution. The macrocyclic ring system cyclododecane was subjected to an MD simulation at 1000 K and 71 different conformations could be sampled. These conformations were compared with the results of previously reported conformational analyses using stochastic search methods, and the MD method...

  1. Twelve tips to promote successful development of a learner performance dashboard within a medical education program.

    Science.gov (United States)

    Boscardin, Christy; Fergus, Kirkpatrick B; Hellevig, Bonnie; Hauer, Karen E

    2017-11-09

    Easily accessible and interpretable performance data constitute critical feedback for learners that facilitate informed self-assessment and learning planning. To provide this feedback, there has been a proliferation of educational dashboards in recent years. An educational (learner) dashboard systematically delivers timely and continuous feedback on performance and can provide easily visualized and interpreted performance data. In this paper, we provide practical tips for developing a functional, user-friendly individual learner performance dashboard and literature review of dashboard development, assessment theory, and users' perspectives. Considering key design principles and maximizing current technological advances in data visualization techniques can increase dashboard utility and enhance the user experience. By bridging current technology with assessment strategies that support learning, educators can continue to improve the field of learning analytics and design of information management tools such as dashboards in support of improved learning outcomes.

  2. Twelve-year history of late-life depression and subsequent feelings to God

    NARCIS (Netherlands)

    Braam, A.W.; Schaap - Jonker, H.; Horst, M.H.L.; Steunenberg, B.; Beekman, A.T.F.; Tilburg, W. van; Deeg, D.J.H.

    2014-01-01

    Objectives: Growing evidence shows several possible relations between religiousness and late-life depression. Emotional aspects of religiousness such as facets of the perceived relationship with God can be crucial in this connection. The aim of the current study was to examine the association

  3. Twelve-year history of late-life depression and subsequent feelings to God

    NARCIS (Netherlands)

    Braam, A.W.; Schaap-Jonker, H.; van der Horst, M.H.L.; Steunenberg, B.; Beekman, A.T.F.; van Tilburg, W.; Deeg, D.J.H.

    2014-01-01

    Objectives Growing evidence shows several possible relations between religiousness and late-life depression. Emotional aspects of religiousness such as facets of the perceived relationship with God can be crucial in this connection. The aim of the current study was to examine the association between

  4. The work environment in the twelve EU-countries: Differences and similarities

    NARCIS (Netherlands)

    Smulders, P.G.W.; Kompier, M.A.J.; Paoli, P.

    1996-01-01

    A survey on the work environment in Europe was carried out by the European Union in 1991. The sample of the study was 12,500 workers (about 1000 per country) and was representative for the workforce distribution in the EU according to occupation, gender, age, economic sectors, and company size. With

  5. Man and Nature: Cognitive and Emotional Elements in the Views of Twelve-Year-Old Schoolchildren.

    Science.gov (United States)

    Aho, Leena

    1984-01-01

    Studied viewpoints of 12-year-old Finnish students concerning the relation between man and nature and their own relation toward the natural world. Examined the cognitive level of thought processes, emotional considerations, and experiences shown in pupils' opinions. Found social, socio-economical, ecological, and ethical considerations had greater…

  6. Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China.

    Science.gov (United States)

    Sun, Ge; Xu, Zhe-Ming; Liang, Jian-Feng; Li, Lin; Tang, Da-Xing

    2011-11-01

    One of the challenges that pediatricians face when examining birth defects is to understand the trends in its occurrence and provide clues to etiology. This study was undertaken to retrospectively assess the prevalence of 10 common neonatal congenital malformations by reviewing a database of all deliveries from 28 weeks up until 7 days of birth from January 1998 to December 2009 in Zhejiang Province, China. Ten common neonatal congenital malformations were selected for analysis. The incidence and the Cochran-Armitage Trend were assessed via SAS9.2. A P value ≤0.05 was considered statistically significant. Of 83 888 perinatals, 374 (4.46‰) suffered from congenital heart diseases (CHD), 77 (0.92‰) from congenital hydrocephalus, 32 (0.38‰) from intestinal atresia/stenosis, 36 (0.43‰) from anorectal malformations, 149 (1.78‰) from kidney malformations, 139 (3.31‰) from hypospadias (male), 178 (2.12‰) from orofacial clefts (OFC), 188 (2.24‰) from polydactyly, 62 (0.74‰) from syndactyly, and 269 (3.21‰) from accessory auricle anomaly. Their trend of prevalence varied as follows: CHD, P=0.0026; hydrocephalus, P=0.0042; intestinal atresia/stenosis, P=0.0103; anorectal malformations, P=0.4332; kidney malformations, Pmalformations (Pmalformations (P=0.4332), polydactyly (P=0.0867) and syndactyly (P=0.1941). The incidences of CHD, intestinal atresia/stenosis, kidney malformations, hypospadias, OFC, and accessory auricle anomaly have increased in the last 12 years, but the incidences of anorectal malformations, polydactyly and syndactyly remain stable. The incidence of hydrocephalus shows a downward trend.

  7. Using YouTube to Teach Presidential Election Propaganda: Twelve Representative Videos

    Science.gov (United States)

    Journell, Wayne

    2009-01-01

    One of the primary goals of social studies education in the United States is to prepare students for civically active, politically informed, and socially engaged democratic citizenship. Too often, however, the curricula fall short of this goal. Textbooks and state curriculum standards tend to portray citizenship as a static concept rather than an…

  8. Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3

    DEFF Research Database (Denmark)

    Yin, Jiaoyang; Vogel, Ulla; Gerdes, Lars Ulrik

    2003-01-01

    The genetic susceptibility to basal cell carcinoma (BCC) among Danish psoriatic patients was investigated in association studies with 12 single nucleotide polymorphisms on chromosome 19q13.2-3. The results show a significant association between BCC and the A-allele of a polymorphism in ERCCI exon4...

  9. Twelve tips for maximizing the effectiveness of game-based learning.

    Science.gov (United States)

    Pitt, Michael B; Borman-Shoap, Emily C; Eppich, Walter J

    2015-01-01

    Game-based learning (GBL) in medical education is emerging as a valid alternative to traditional teaching methods. Well-designed GBL sessions use non-threatening competition to capitalize on heightened learner arousal, allowing for high-level engagement and dynamic group discussion. While many templates for specific educational games have been published, little has been written on strategies for educators to create their own or how to use them with maximal effectiveness. These 12 tips provide specific recommendations for the successful design and implementation of GBL sessions in medical education based on a review of the literature and insight from experienced designers.

  10. Development of the social brain from age three to twelve years.

    Science.gov (United States)

    Richardson, Hilary; Lisandrelli, Grace; Riobueno-Naylor, Alexa; Saxe, Rebecca

    2018-03-12

    Human adults recruit distinct networks of brain regions to think about the bodies and minds of others. This study characterizes the development of these networks, and tests for relationships between neural development and behavioral changes in reasoning about others' minds ('theory of mind', ToM). A large sample of children (n = 122, 3-12 years), and adults (n = 33), watched a short movie while undergoing fMRI. The movie highlights the characters' bodily sensations (often pain) and mental states (beliefs, desires, emotions), and is a feasible experiment for young children. Here we report three main findings: (1) ToM and pain networks are functionally distinct by age 3 years, (2) functional specialization increases throughout childhood, and (3) functional maturity of each network is related to increasingly anti-correlated responses between the networks. Furthermore, the most studied milestone in ToM development, passing explicit false-belief tasks, does not correspond to discontinuities in the development of the social brain.

  11. Detection panel for identification of twelve hemorrhagic viruses using real-time RT-PCR.

    Science.gov (United States)

    Fajfr, M; Neubauerová, V; Pajer, P; Kubíčková, P; Růžek, D

    2014-09-01

    Viral hemorrhagic fevers are caused by viruses from four viral families and develop diseases with high fatality rates. However, no commercial diagnostic assay for these pathogens is available. We developed real-time RT-PCR assays for viruses Ebola, Marburg, Lassa, Guanarito, Machupo, Junin, Sabiá, Seoul, Puumala, Hantaan, Crimean-Congo hemorrhagic fever virus and Rift Valley fever virus. The assays were optimized for identical reaction conditions and can be performed using several types of real-time PCR instruments, both capillary and plate, including a portable Ruggedized Advanced Pathogen Identification Device (R.A.P.I.D.) (Idaho Technology, Inc.). In combination with primers and probes from previously published studies, we present a simple system for rapid identification of hemorrhagic filoviruses, arenaviruses and bunyaviruses with sufficient sensitivity for first contact laboratory and diagnosis under field conditions.

  12. Teaching Design in Television Production Technology: The Twelve Steps of Preproduction

    Science.gov (United States)

    Harrison, Henry L. (Hal), III; Loveland, Thomas

    2009-01-01

    Extensive planning must be used to produce television programs. Students must develop sound design practices and understand these attributes of design in their production planning. Through the design and planning processes involved in television production, students learn that design is a creative process, and that there is no perfect design, but…

  13. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    DEFF Research Database (Denmark)

    Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur

    2010-01-01

    By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals...

  14. 17 CFR 210.3-06 - Financial statements covering a period of nine to twelve months.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Financial statements covering... SECURITIES AND EXCHANGE COMMISSION FORM AND CONTENT OF AND REQUIREMENTS FOR FINANCIAL STATEMENTS, SECURITIES... General Instructions As to Financial Statements § 210.3-06 Financial statements covering a period of nine...

  15. An Assessment of Twelve Cases of HELLP Syndrome Treated at the ...

    African Journals Online (AJOL)

    Prominent presenting clinical features included preeclampsia (proteinuria and hypertension), eclampsia, jaundice, epigastric pain, anorexia and malaise. Relevant laboratory profiles on all patients met the criteria for confirmation of the diagnosis of HELLP syndrome. Important complications were disseminated intravascular ...

  16. Twelve worlds: a geo-demographic comparison of global inequalities in mortality.

    Science.gov (United States)

    Day, P; Pearce, J; Dorling, D

    2008-11-01

    The aim of this study was to identify clusters of nations grouped by health outcomes in order to provide sensible groupings for international comparisons. The utility of this approach is demonstrated by comparing life expectancy and a range of health system indicators within and between each cluster. Age- and sex-specific mortality data for 190 member states were extracted from the Burden of Disease Estimates statistics produced by the World Health Organization. A hierarchical cluster method was used to identify groupings of countries that are homogeneous in terms of mortality rates. 12 clusters of countries were identified. The average life expectancy of each cluster ranged from 81.5 years (cluster 1) to 37.7 years (cluster 12). The two highest ranked clusters were dominated by Western European countries, Australia, Japan and Canada. Cluster 3 included the UK and USA. The four clusters with the lowest life expectancies were characterised by different configurations of African countries. Health system indicators for workforce, hospital beds, access to medicines and measles vaccination corresponded well with a clear association with cluster life expectancy. On a per capita basis, worldwide health spending was concentrated within the three highest life expectancy clusters, especially cluster 3 containing the USA. Considerable inequalities in life expectancy and healthcare are made clearer when viewed across clusters of countries grouped by health outcomes. This geo-demographic taxonomy of global mortality has advantages over traditional more ad hoc systems for comparing global health inequalities and for deciding which countries appear to have the most comparable health outcomes.

  17. Macrobenthic Community Structure in the Northwestern Arabian Gulf, Twelve Years after the 1991 Oil Spill

    KAUST Repository

    Joydas, Thadickal V.

    2017-08-03

    The biota in the Arabian Gulf faces stress both from natural (i.e., hyper salinity and high sea surface temperature), and human (i.e., from oil-related activities) sources. The western Arabian Gulf was also impacted by world\\'s largest oil spill (1991 Oil Spill). However, benthic research in this region is scarce and most of the studies have been conducted only in small areas. Here, we present data on macrobenthos collected during 2002–2003 from the open waters and inner bays in the northwestern Arabian Gulf aimed to assess the ecological status and also to evaluate the long-term impact, if any, of the 1991 Oil Spill. A total of 392 macrobenthic taxa with an average (±SE) species richness (S) of 71 ± 2, Shannon-Wiener species diversity (H′) of 4.9 ± 0.1, and density of 3,181 ± 359 ind. m−2 was recorded from the open water stations. The open waters have “slightly disturbed” (according to AZTI\\'s Marine Biotic Index, AMBI) conditions, with “good-high” (according to multivariate-AMBI, M-AMBI) ecological status indicating the absence of long-term impacts of the oil spill. Overall, 162 taxa were recorded from inner bays with average (±SE) values of S 41 ± 9, H′ 3.48 ± 0.39, and density 4,203 ± 1,042 ind. m−2. The lower TPH (Total Petroleum Hydrocarbons) stations (LTS, TPH concentrations <70 mg kg−2) show relatively higher S, H\\' and density compared to the higher TPH stations (HTS, TPH concentrations ≥100 mg kg−2). In the inner bays, AMBI values indicate slightly disturbed conditions at all stations except one, which is moderately disturbed. M-AMBI values indicate good status at LTS, while, high, good, moderate, and poor status at HTS. The “moderately disturbed” conditions with “moderate-poor” ecological status in some locations of the inner bays specify a severe long-term impact of the oil spill.

  18. Autoextraction of twelve permanent teeth in a child with autistic spectrum disorder.

    Science.gov (United States)

    Williams, Anne C

    2016-03-01

    This report discusses self-injurious behaviour; this is not unusual in people with autistic spectrum disorders but is not commonly experienced as autoextraction. This case concerns a 12 year old child who presented as a new patient with two teeth missing. He then went on to remove a further ten teeth over a relatively short space of time. The recognition of autoextraction by the dental team is important. its management involves a multidisciplinary team which includes professionals from education, health and social care who work together to prevent progressive self-injury. © 2015 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    NARCIS (Netherlands)

    B.F. Voight (Benjamin); L.J. Scott (Laura); V. Steinthorsdottir (Valgerdur); A.D. Morris (Andrew); C. Dina (Christian); R.P. Welch (Ryan); E. Zeggini (Eleftheria); C. Huth (Cornelia); Y.S. Aulchenko (Yurii); G. Thorleifsson (Gudmar); L.J. McCulloch (Laura); T. Ferreira (Teresa); H. Grallert (Harald); N. Amin (Najaf); G. Wu (Guanming); C.J. Willer (Cristen); S. Raychaudhuri (Soumya); S.A. McCarroll (Steven); C. Langenberg (Claudia); O.M. Hofmann (Oliver); J. Dupuis (Josée); L. Qi (Lu); A.V. Segrè (Ayellet); M. van Hoek (Mandy); P. Navarro (Pau); K.G. Ardlie (Kristin); B. Balkau (Beverley); R. Benediktsson (Rafn); A.J. Bennett (Amanda); R. Blagieva (Roza); E.A. Boerwinkle (Eric); L.L. Bonnycastle (Lori); K.B. Boström (Kristina Bengtsson); B. Bravenboer (Bert); S. Bumpstead (Suzannah); N.P. Burtt (Noël); G. Charpentier (Guillaume); P.S. Chines (Peter); M. Cornelis (Marilyn); D.J. Couper (David); G. Crawford (Gabe); A.S.F. Doney (Alex); K.S. Elliott (Katherine); M.R. Erdos (Michael); C.S. Fox (Caroline); C.S. Franklin (Christopher); M. Ganser (Martha); C. Gieger (Christian); N. Grarup (Niels); T. Green (Todd); S. Griffin (Simon); C.J. Groves (Christopher); C. Guiducci (Candace); S. Hadjadj (Samy); N. Hassanali (Neelam); C. Herder (Christian); B. Isomaa (Bo); A.U. Jackson (Anne); P.R.V. Johnson (Paul); T. Jørgensen (Torben); W.H.L. Kao (Wen); N. Klopp (Norman); A. Kong (Augustine); P. Kraft (Peter); J. Kuusisto (Johanna); T. Lauritzen (Torsten); M. Li (Man); A. Lieverse (Aloysius); C.M. Lindgren (Cecilia); V. Lyssenko (Valeriya); M. Marre (Michel); T. Meitinger (Thomas); K. Midthjell (Kristian); M.A. Morken (Mario); N. Narisu (Narisu); P. Nilsson (Peter); K.R. Owen (Katharine); F. Payne (Felicity); J.R.B. Perry (John); A.K. Petersen; C. Platou (Carl); C. Proença (Christine); I. Prokopenko (Inga); W. Rathmann (Wolfgang); N.W. Rayner (Nigel William); N.R. Robertson (Neil); G. Rocheleau (Ghislain); M. Roden (Michael); M.J. Sampson (Michael); R. Saxena (Richa); B.M. Shields (Beverley); P. Shrader (Peter); G. Sigurdsson (Gunnar); T. Sparsø (Thomas); K. Strassburger (Klaus); H.M. Stringham (Heather); Q. Sun (Qi); A.J. Swift (Amy); B. Thorand (Barbara); J. Tichet (Jean); T. Tuomi (Tiinamaija); R.M. van Dam (Rob); T.W. van Haeften (Timon); T.W. van Herpt (Thijs); J.V. van Vliet-Ostaptchouk (Jana); G.B. Walters (Bragi); M.N. Weedon (Michael); C. Wijmenga (Cisca); J.C.M. Witteman (Jacqueline); R.N. Bergman (Richard); S. Cauchi (Stephane); F.S. Collins (Francis); A.L. Gloyn (Anna); U. Gyllensten (Ulf); T. Hansen (Torben); W.A. Hide (Winston); G.A. Hitman (Graham); A. Hofman (Albert); D. Hunter (David); K. Hveem (Kristian); M. Laakso (Markku); K.L. Mohlke (Karen); C.N.A. Palmer (Colin); P.P. Pramstaller (Peter Paul); I. Rudan (Igor); E.J.G. Sijbrands (Eric); L.D. Stein (Lincoln); J. Tuomilehto (Jaakko); A.G. Uitterlinden (André); M. Walker (Mark); N.J. Wareham (Nick); G.R. Abecasis (Gonçalo); B.O. Boehm (Bernhard); H. Campbell (Harry); M.J. Daly (Mark); A.T. Hattersley (Andrew); F.B. Hu (Frank); J.B. Meigs (James); J.S. Pankow (James); O. Pedersen (Oluf); H.E. Wichmann (Erich); I.E. Barroso (Inês); J.C. Florez (Jose); T.M. Frayling (Timothy); L. Groop (Leif); R. Sladek (Rob); U. Thorsteinsdottir (Unnur); J.F. Wilson (James); T. Illig (Thomas); P. Froguel (Philippe); P. Tikka-Kleemola (Päivi); J-A. Zwart (John-Anker); D. Altshuler (David); M. Boehnke (Michael); M.I. McCarthy (Mark); R.M. Watanabe (Richard)

    2010-01-01

    textabstractBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals

  20. VARIATION IN BIOFUEL POTENTIAL OF TWELVE CALOPYLLUM INOPHYLLUM POPULATIONS IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Budi Leksono

    2016-05-01

    Full Text Available The global energy crisis has raises demand for biofuel prices. It has driven the world to enhance environmentally-friendly renewable-energy (biofuel production. Oil from the seeds of Calophyllum inophyllum (nyamplung which can be harvested up to 50 years, is one of  such potential biofuel source. Methods for biofuel production from nyamplung seeds have been developed at an industrial scale by cooperative in Cilacap (Java and Energy Self-Sufficient Villages (Desa Mandiri Energi in Banyuwangi, Purworejo, Kebumen, Ujung Kulon (Java and Selayar (South Sulawesi. However, there is only a limited-information available on biofuel potential, in term of  productivity and quality, from nyamplung populations. This paper reports the variations in biofuel potential among 12 populations in Indonesia (6 from Java, 6 outside Java. The oil was extracted using a combination of  vertical hot press (VHP and screw press expeller (SPE methods, followed by degumming to make refined oil, and esterification-transesterification to turn it into biodiesel. The result show great variation of  biofuel content among the population. Oil production percentage varies from 37-48.5% (VHP and 50-58% (SPE crude oil, 36-48% (VHP and 40-53% (SPE refined oil, and 1733% (SPE for biodiesel. Seed resin content is responsible for most of the variation after degumming. DNA analysis shows genetic variation among populations ranges from intermediate within Java to high ouside Java and is intermediate within populations. Information about biofuel content and potential of  populations and genetic variation between and within population are important factors for establishment of  geneticallyimproved seed-sources for biofuel production from nyamplung.

  1. Analysis of twelve-month degradation in three polycrystalline photovoltaic modules

    Science.gov (United States)

    Lai, T.; Potter, B. G.; Simmons-Potter, K.

    2016-09-01

    Polycrystalline silicon photovoltaic (PV) modules have the advantage of lower manufacturing cost as compared to their monocrystalline counterparts, but generally exhibit both lower initial module efficiencies and more significant early-stage efficiency degradation than do similar monocrystalline PV modules. For both technologies, noticeable deterioration in power conversion efficiency typically occurs over the first two years of usage. Estimating PV lifetime by examining the performance degradation behavior under given environmental conditions is, therefore, one of continual goals for experimental research and economic analysis. In the present work, accelerated lifecycle testing (ALT) on three polycrystalline PV technologies was performed in a full-scale, industrial-standard environmental chamber equipped with single-sun irradiance capability, providing an illumination uniformity of 98% over a 2 x 1.6m area. In order to investigate environmental aging effects, timedependent PV performance (I-V characteristic) was evaluated over a recurring, compressed day-night cycle, which simulated local daily solar insolation for the southwestern United States, followed by dark (night) periods. During a total test time of just under 4 months that corresponded to a year equivalent exposure on a fielded module, the temperature and humidity varied in ranges from 3°C to 40°C and 5% to 85% based on annual weather profiles for Tucson, AZ. Removing the temperature de-rating effect that was clearly seen in the data enabled the computation of normalized efficiency degradation with time and environmental exposure. Results confirm the impact of environmental conditions on the module long-term performance. Overall, more than 2% efficiency degradation in the first year of usage was observed for all thee polycrystalline Si solar modules. The average 5-year degradation of each PV technology was estimated based on their determined degradation rates.

  2. Identification of twelve new susceptibility loci for different histotypes of epithelial ovarian cancer

    Science.gov (United States)

    Phelan, Catherine M.; Kuchenbaecker, Karoline B.; Tyrer, Jonathan P.; Kar, Siddhartha P.; Lawrenson, Kate; Winham, Stacey J.; Dennis, Joe; Pirie, Ailith; Riggan, Marjorie; Chornokur, Ganna; Earp, Madalene A.; Lyra, Paulo C.; Lee, Janet M.; Coetzee, Simon; Beesley, Jonathan; McGuffog, Lesley; Soucy, Penny; Dicks, Ed; Lee, Andrew; Barrowdale, Daniel; Lecarpentier, Julie; Leslie, Goska; Aalfs, Cora M.; Aben, Katja K.H.; Adams, Marcia; Adlard, Julian; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia; Aravantinos, Gerasimos; Arnold, Norbert; Arun, Banu K.; Arver, Brita; Azzollini, Jacopo; Balmaña, Judith; Banerjee, Susana N.; Barjhoux, Laure; Barkardottir, Rosa B.; Bean, Yukie; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Benitez, Javier; Bermisheva, Marina; Bernardini, Marcus Q.; Birrer, Michael J.; Bjorge, Line; Black, Amanda; Blankstein, Kenneth; Blok, Marinus J.; Bodelon, Clara; Bogdanova, Natalia; Bojesen, Anders; Bonanni, Bernardo; Borg, Åke; Bradbury, Angela R.; Brenton, James D.; Brewer, Carole; Brinton, Louise; Broberg, Per; Brooks-Wilson, Angela; Bruinsma, Fiona; Brunet, Joan; Buecher, Bruno; Butzow, Ralf; Buys, Saundra S.; Caldes, Trinidad; Caligo, Maria A.; Campbell, Ian; Cannioto, Rikki; Carney, Michael E.; Cescon, Terence; Chan, Salina B.; Chang-Claude, Jenny; Chanock, Stephen; Chen, Xiao Qing; Chiew, Yoke-Eng; Chiquette, Jocelyne; Chung, Wendy K.; Claes, Kathleen B.M.; Conner, Thomas; Cook, Linda S.; Cook, Jackie; Cramer, Daniel W.; Cunningham, Julie M.; D’Aloisio, Aimee A.; Daly, Mary B.; Damiola, Francesca; Damirovna, Sakaeva Dina; Dansonka-Mieszkowska, Agnieszka; Dao, Fanny; Davidson, Rosemarie; DeFazio, Anna; Delnatte, Capucine; Doheny, Kimberly F.; Diez, Orland; Ding, Yuan Chun; Doherty, Jennifer Anne; Domchek, Susan M.; Dorfling, Cecilia M.; Dörk, Thilo; Dossus, Laure; Duran, Mercedes; Dürst, Matthias; Dworniczak, Bernd; Eccles, Diana; Edwards, Todd; Eeles, Ros; Eilber, Ursula; Ejlertsen, Bent; Ekici, Arif B.; Ellis, Steve; Elvira, Mingajeva; Eng, Kevin H.; Engel, Christoph; Evans, D. Gareth; Fasching, Peter A.; Ferguson, Sarah; Ferrer, Sandra Fert; Flanagan, James M.; Fogarty, Zachary C.; Fortner, Renée T.; Fostira, Florentia; Foulkes, William D.; Fountzilas, George; Fridley, Brooke L.; Friebel, Tara M.; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; García, María J.; Garcia-Barberan, Vanesa; Gehrig, Andrea; Gentry-Maharaj, Aleksandra; Gerdes, Anne-Marie; Giles, Graham G.; Glasspool, Rosalind; Glendon, Gord; Godwin, Andrew K.; Goldgar, David E.; Goranova, Teodora; Gore, Martin; Greene, Mark H.; Gronwald, Jacek; Gruber, Stephen; Hahnen, Eric; Haiman, Christopher A.; Håkansson, Niclas; Hamann, Ute; Hansen, Thomas V.O.; Harrington, Patricia A.; Harris, Holly R; Hauke, Jan; Hein, Alexander; Henderson, Alex; Hildebrandt, Michelle A.T.; Hillemanns, Peter; Hodgson, Shirley; Høgdall, Claus K.; Høgdall, Estrid; Hogervorst, Frans B.L.; Holland, Helene; Hooning, Maartje J.; Hosking, Karen; Huang, Ruea-Yea; Hulick, Peter J.; Hung, Jillian; Hunter, David J.; Huntsman, David G.; Huzarski, Tomasz; Imyanitov, Evgeny N.; Isaacs, Claudine; Iversen, Edwin S.; Izatt, Louise; Izquierdo, Angel; Jakubowska, Anna; James, Paul; Janavicius, Ramunas; Jernetz, Mats; Jensen, Allan; Jensen, Uffe Birk; John, Esther M.; Johnatty, Sharon; Jones, Michael E.; Kannisto, Päivi; Karlan, Beth Y.; Karnezis, Anthony; Kast, Karin; Kennedy, Catherine J.; Khusnutdinova, Elza; Kiemeney, Lambertus A.; Kiiski, Johanna I.; Kim, Sung-Won; Kjaer, Susanne K.; Köbel, Martin; Kopperud, Reidun K.; Kruse, Torben A.; Kupryjanczyk, Jolanta; Kwong, Ava; Laitman, Yael; Lambrechts, Diether; Larrañaga, Nerea; Larson, Melissa C.; Lazaro, Conxi; Le, Nhu D.; Le Marchand, Loic; Lee, Jong Won; Lele, Shashikant B.; Leminen, Arto; Leroux, Dominique; Lester, Jenny; Lesueur, Fabienne; Levine, Douglas A.; Liang, Dong; Liebrich, Clemens; Lilyquist, Jenna; Lipworth, Loren; Lissowska, Jolanta; Lu, Karen H.; Lubiński, Jan; Luccarini, Craig; Lundvall, Lene; Mai, Phuong L.; Mendoza-Fandiño, Gustavo; Manoukian, Siranoush; Massuger, Leon F.A.G.; May, Taymaa; Mazoyer, Sylvie; McAlpine, Jessica N.; McGuire, Valerie; McLaughlin, John R.; McNeish, Iain; Meijers-Heijboer, Hanne; Meindl, Alfons; Menon, Usha; Mensenkamp, Arjen R.; Merritt, Melissa A.; Milne, Roger L.; Mitchell, Gillian; Modugno, Francesmary; Moes-Sosnowska, Joanna; Moffitt, Melissa; Montagna, Marco; Moysich, Kirsten B.; Mulligan, Anna Marie; Musinsky, Jacob; Nathanson, Katherine L.; Nedergaard, Lotte; Ness, Roberta B.; Neuhausen, Susan L.; Nevanlinna, Heli; Niederacher, Dieter; Nussbaum, Robert L.; Odunsi, Kunle; Olah, Edith; Olopade, Olufunmilayo I.; Olsson, Håkan; Olswold, Curtis; O’Malley, David M.; Ong, Kai-ren; Onland-Moret, N. Charlotte; Orr, Nicholas; Orsulic, Sandra; Osorio, Ana; Palli, Domenico; Papi, Laura; Park-Simon, Tjoung-Won; Paul, James; Pearce, Celeste L.; Pedersen, Inge Søkilde; Peeters, Petra H.M.; Peissel, Bernard; Peixoto, Ana; Pejovic, Tanja; Pelttari, Liisa M.; Permuth, Jennifer B.; Peterlongo, Paolo; Pezzani, Lidia; Pfeiler, Georg; Phillips, Kelly-Anne; Piedmonte, Marion; Pike, Malcolm C.; Piskorz, Anna M.; Poblete, Samantha R.; Pocza, Timea; Poole, Elizabeth M.; Poppe, Bruce; Porteous, Mary E.; Prieur, Fabienne; Prokofyeva, Darya; Pugh, Elizabeth; Pujana, Miquel Angel; Pujol, Pascal; Radice, Paolo; Rantala, Johanna; Rappaport-Fuerhauser, Christine; Rennert, Gad; Rhiem, Kerstin; Rice, Patricia; Richardson, Andrea; Robson, Mark; Rodriguez, Gustavo C.; Rodríguez-Antona, Cristina; Romm, Jane; Rookus, Matti A.; Rossing, Mary Anne; Rothstein, Joseph H.; Rudolph, Anja; Runnebaum, Ingo B.; Salvesen, Helga B.; Sandler, Dale P.; Schoemaker, Minouk J.; Senter, Leigha; Setiawan, V. Wendy; Severi, Gianluca; Sharma, Priyanka; Shelford, Tameka; Siddiqui, Nadeem; Side, Lucy E.; Sieh, Weiva; Singer, Christian F.; Sobol, Hagay; Song, Honglin; Southey, Melissa C.; Spurdle, Amanda B.; Stadler, Zsofia; Steinemann, Doris; Stoppa-Lyonnet, Dominique; Sucheston-Campbell, Lara E.; Sukiennicki, Grzegorz; Sutphen, Rebecca; Sutter, Christian; Swerdlow, Anthony J.; Szabo, Csilla I.; Szafron, Lukasz; Tan, Yen Y.; Taylor, Jack A.; Tea, Muy-Kheng; Teixeira, Manuel R.; Teo, Soo-Hwang; Terry, Kathryn L.; Thompson, Pamela J.; Thomsen, Liv Cecilie Vestrheim; Thull, Darcy L.; Tihomirova, Laima; Tinker, Anna V.; Tischkowitz, Marc; Tognazzo, Silvia; Toland, Amanda Ewart; Tone, Alicia; Trabert, Britton; Travis, Ruth C.; Trichopoulou, Antonia; Tung, Nadine; Tworoger, Shelley S.; van Altena, Anne M.; Van Den Berg, David; van der Hout, Annemarie H.; van der Luijt, Rob B.; Van Heetvelde, Mattias; Van Nieuwenhuysen, Els; van Rensburg, Elizabeth J.; Vanderstichele, Adriaan; Varon-Mateeva, Raymonda; Ana, Vega; Edwards, Digna Velez; Vergote, Ignace; Vierkant, Robert A.; Vijai, Joseph; Vratimos, Athanassios; Walker, Lisa; Walsh, Christine; Wand, Dorothea; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Webb, Penelope M.; Weinberg, Clarice R.; Weitzel, Jeffrey N.; Wentzensen, Nicolas; Whittemore, Alice S.; Wijnen, Juul T.; Wilkens, Lynne R.; Wolk, Alicja; Woo, Michelle; Wu, Xifeng; Wu, Anna H.; Yang, Hannah; Yannoukakos, Drakoulis; Ziogas, Argyrios; Zorn, Kristin K.; Narod, Steven A.; Easton, Douglas F.; Amos, Christopher I.; Schildkraut, Joellen M.; Ramus, Susan J.; Ottini, Laura; Goodman, Marc T.; Park, Sue K.; Kelemen, Linda E.; Risch, Harvey A.; Thomassen, Mads; Offit, Kenneth; Simard, Jacques; Schmutzler, Rita Katharina; Hazelett, Dennis; Monteiro, Alvaro N.; Couch, Fergus J.; Berchuck, Andrew; Chenevix-Trench, Georgia; Goode, Ellen L.; Sellers, Thomas A.; Gayther, Simon A.; Antoniou, Antonis C.; Pharoah, Paul D.P.

    2017-01-01

    To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3, 9q31.1) and one for endometrioid EOC (5q12.3). We then meta-analysed the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified an additional three loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a novel susceptibility gene for low grade/borderline serous EOC. PMID:28346442

  3. Twelve tips on how to set up postgraduate training via remote clinical supervision

    DEFF Research Database (Denmark)

    Wearne, Susan; Dornan, Tim; Teunissen, Pim W.

    2013-01-01

    Doctors-in-training can now be supervised remotely by specialist clinicians using information and communication technology. This provides an intermediate stage of professional development between on-site supervision and independent medical practice. Remote supervision could increase training capa...

  4. Twelve-month follow-up of cognitive behavioral therapy for children with functional abdominal pain.

    Science.gov (United States)

    Levy, Rona L; Langer, Shelby L; Walker, Lynn S; Romano, Joan M; Christie, Dennis L; Youssef, Nader; DuPen, Melissa M; Ballard, Sheri A; Labus, Jennifer; Welsh, Ericka; Feld, Lauren D; Whitehead, William E

    2013-02-01

    To determine whether a brief intervention for children with functional abdominal pain and their parents' responses to their child's pain resulted in improved coping 12 months later. Prospective, randomized, longitudinal study. Families were recruited during a 4-year period in Seattle, Washington, and Morristown, New Jersey. Two hundred children with persistent functional abdominal pain and their parents. A 3-session social learning and cognitive behavioral therapy intervention or an education and support intervention. Child symptoms and pain-coping responses were monitored using standard instruments, as was parental response to child pain behavior. Data were collected at baseline and after treatment (1 week and 3, 6, and 12 months after treatment). This article reports the 12-month data. Relative to children in the education and support group, children in the social learning and cognitive behavioral therapy group reported greater baseline to 12-month follow-up decreases in gastrointestinal symptom severity (estimated mean difference, -0.36; 95% CI, -0.63 to -0.01) and greater improvements in pain-coping responses (estimated mean difference, 0.61; 95% CI, 0.26 to 1.02). Relative to parents in the education and support group, parents in the social learning and cognitive behavioral therapy group reported greater baseline to 12-month decreases in solicitous responses to their child's symptoms (estimated mean difference, -0.22; 95% CI, -0.42 to -0.03) and greater decreases in maladaptive beliefs regarding their child's pain (estimated mean difference, -0.36; 95% CI, -0.59 to -0.13). Results suggest long-term efficacy of a brief intervention to reduce parental solicitousness and increase coping skills. This strategy may be a viable alternative for children with functional abdominal pain. clinicaltrials.gov Identifier: NCT00494260.

  5. Comparison ofYield of TwelveBasilCultivarsinTwo Provinces:Isfahan and Mazandaran

    Directory of Open Access Journals (Sweden)

    Nahid Amoli

    2017-12-01

    Full Text Available Introduction: Basil(Ocimumbasilicum L.is a diploid plant with48chromosomes. Basil isthe aromatic annual herbofthe Lamiaceae familyofleafy vegetablesandhas mentionedand originated inIndiaandIran. Basilhasiron, calcium, magnesium, potassiumandvitamins Aand B. More than 60 varietiesof basilhave been identifiedthathavegreenleavesandredto purple.The performance of15varietiesof basilin Mazandaran province were studied, genotypescollected fromSari(darkgreen withthe23.63 tha-1(fresh weight had thehighestyield. In comparison, 38the massbasil, withtwocultivars(Opal andKashkanyLulu, localpopulationsofmanyof the traits(e.g.,length and width ofleavesandfresh and dry weight showed superiority than cultivars. Incomparing the performance of38varietiesof basilinItaly, drymatter yieldper hectarerangedfrom1812 to6165kg ha-1thatthis wasmore attributestobegenetic aspects. Landraces ofbasilhavevaluabletraitssuch asdrought resistance, saltresistance, resistancetodisease, resistancetocoldandheat. In order to achieveoptimalpopulationpurple basil with high-performance inIsfahan andMazandaran, the present studywas conducted usingsomeof the populationinthese two provinces. Materials and Methods: The number of populations of purple basil wasstudied toselect superior genotypes according to the yield and adaptation to climatic conditions in two provinces at Agricultural Research Station Gharahil of Mazandaran and Kabootarabad of Isfahan. The experiment was conducted as a randomized complete block design with three replications with seeds collected from two areas of the province (a total of 12 varieties of basil during one year. Land preparationwas consisted ofplowanddiscperpendicular to each other(for crushinghunk and thenlevelingandplotsofland. Inprovinces, nitrogen, phosphorusandpotassiumfertilizerwas used based on soiltest.In this experiment,harvest time was4st. for every two region. Duringthe growing seasonweed controlwascarried outmechanically. Result and Discussions: In both areas, the yield and plant height (at 5% statistical probability level and the number of leaves per plant (at 1% statistical probability level were statisticallysignificant. In Isfahan area, Ghaemshahr red basil mass yield was 17.1 t ha-1, but the yield of this mass were not significantly different with Farah Abad, Bahnamiri, Dastgerd, Mobarake, Ardestan and Dorche. The yield of Mazandaran 1,Mazandaran 2 and Najaf Abad masses were 11.61, 11.02, and 11.10, respectively, that had the lowest performance among the masses. In Mazandaran region, in most cases, the yields of all 12 purple basil mass were twotimes or more than doubles in the Isfahan region. The yield of Mazandaran 2 mass was the lowest in Isfahan region, but had high performance (29.6 t ha-1 in Mazandaran region. In both regions, Ghaemshahr, Neka, Behshahr, Mobarakeh and Ardestān purple basil masses had the highest yield. In Isfahan, plant height rangedfrom19.67(Ardestan to28.00cm, while thisrange in Mazandaran region was 29.7to41.7cm. In a studyin Turkey,a highest height for purple basil without water limitation was38.6cm. Basil plant height has a positive and significant correlation with performance and in addition to genetic factors, environmental characteristics, in particular the amount of moisture available to plants can also have a significant impact on plant height. Among all12 genotypes tested, the number of leaves were 53 (Dastgerd to 73.7 (Behshahr, and the number of leaves rangedfrom 48.3 (Behshahr to 78.3 (Mazandaran 1in Mazandaran. Usually the soil areas withhigh fluctuations in moisture and air (comparison Isfahan with Mazandaran, leaves hada smaller number and leaf area. The number of branches of genotypes was from 12.6 to 16.3in Isfahan region and in the Mazandaran region was from 6.3 to 9.3. Reduce the number of branches in Mazandaran (1.5 to 2 times less related to radiation exposure in the area and its difference with radiation in Isfahan.Usually the weather of Isfahanis sunnyanddirect sunlightwhereas the weather of Mazandaran region iscloudy. In both regions, the greatest contribution performance harvest was in second and third harvest, respectively (although yields were higherin Mazandaran region. The lower yield at first harvest can attributed with opportunity when it is necessary for plant establishment. The fourth harvest yield loss can be two reasons, one terminate of plant growth and aging, and other high temperature at this time. Although basil is a plant that originated from warm zones, but increased plant maintenance respiration can occur at high temperatures is an issue that should be considered.

  6. Twelve tips for using Twitter as a learning tool in medical education.

    Science.gov (United States)

    Forgie, Sarah Edith; Duff, Jon P; Ross, Shelley

    2013-01-01

    Twitter is an online social networking service, accessible from any Internet-capable device. While other social networking sites are online confessionals or portfolios of personal current events, Twitter is designed and used as a vehicle to converse and share ideas. For this reason, we believe that Twitter may be the most likely candidate for integrating social networking with medical education. Using current research in medical education, motivation and the use of social media in higher education, we aim to show the ways Twitter may be used as a learning tool in medical education. A literature search of several databases, online sources and blogs was carried out examining the use of Twitter in higher education. We created 12 tips for using Twitter as a learning tool and organized them into: the mechanics of using Twitter, suggestions and evidence for incorporating Twitter into many medical education contexts, and promoting research into the use of Twitter in medical education. Twitter is a relatively new social medium, and its use in higher education is in its infancy. With further research and thoughtful application of media literacy, Twitter is likely to become a useful adjunct for more personalized teaching and learning in medical education.

  7. Soil microbial metabolic quotient (qCO2) of twelve ecosystems of Mt. Kilimanjaro

    Science.gov (United States)

    Pabst, Holger; Gerschlauer, Friederike; Kiese, Ralf; Kuzyakov, Yakov

    2014-05-01

    Soil organic carbon, microbial biomass carbon (MBC) and the metabolic quotient qCO2 - as sensitive and important parameters for soil fertility and C turnover - are strongly affected by land-use changes all over the world. These effects are particularly distinct upon conversion of natural to agricultural ecosystems due to very fast carbon (C) and nutrient cycles and high vulnerability, especially in the tropics. In this study, we used an elevational gradient on Mt. Kilimanjaro to investigate the effects of land-use change and elevation on Corg, MBC and qCO2. Down to a soil depth of 18 cm we compared 4 natural (Helichrysum, Erica forest, Podocarpus forest, Ocotea forest), 5 seminatural (disturbed Podocarpus forest, disturbed Ocotea forest, lower montane forest, grassland, savannah), 1 sustainably used (homegarden) and 2 intensively used ecosystems (coffee plantation, maize field) on an elevation gradient from 950 to 3880 m a.s.l.. Using an incubation device, soil CO2-efflux of 18 cm deep soil cores was measured under field moist conditions and mean annual temperature. MBC to Corg ratios varied between 0.7 and 2.3%. qCO2 increased with magnitude of the disturbance, albeit this effect decreased with elevation. Following the annual precipitation of the ecosystems, both, Corg and MBC showed a hum-shaped distribution with elevation, whereas their maxima were between 2500 and 3000 m a.s.l.. Additionaly, Corg and MBC contents were significantly reduced in intensively used agricultural systems. We conclude that the soil microbial biomass and its activity in Mt. Kilimanjaro ecosystems are strongly altered by land-use. This effect is more distinct in lower than in higher elevated ecosystems and strongly dependent on the magnitude of disturbance.

  8. Twelve tips for the production of digital chalk-talk videos.

    Science.gov (United States)

    Rana, Jasmine; Besche, Henrike; Cockrill, Barbara

    2017-06-01

    Increasingly over the past decade, faculty in medical and graduate schools have received requests from digital millennial learners for concise faculty-made educational videos. At our institution, over the past couple of years alone, several hundred educational videos have been created by faculty who teach in a flipped-classroom setting of the pre-clinical medical school curriculum. Despite the appeal and potential learning benefits of digital chalk-talk videos first popularized by Khan Academy, we have observed that the conceptual and technological barriers for creating chalk-talk videos can be high for faculty. To this end, this tips article offers an easy-to-follow 12-step conceptual framework to guide at-home production of chalk-talk educational videos.

  9. Twelve tips for the construction of ethical dilemma case-based assessment.

    Science.gov (United States)

    Tsai, Tsuen-Chiuan

    2017-04-01

    Ethical dilemma case-based examination (ethics Script Concordance Test, eSCT) is a written examination that can be delivered to a large group of examinees for the purpose of measuring high-level thinking. As it accommodates for diverse responses from experts, ethics SCT allows partial credits. The framework of ethics SCT includes a vignette with an ethical dilemma and a leading question, which asks the examinee to "agree" or "disagree", plus the shifts of prior decision by adding new information. In this article, the following tips for constructing this type of examination are provided: use "true" dilemmas, select an appropriate ethical issue, target high-level cognitive tasks, list key components, keep a single central theme, device quality scoring system, be important and plausible, be clear, select quality experts, validate, know the limitation, and be familiar with test materials. The use of eSCT to measure ethical reasoning ability appears to be both viable and desirable.

  10. Full investment stop without tax relief. Twelve fields downgraded because of tax and prices

    International Nuclear Information System (INIS)

    Ramm, H.H.

    1994-01-01

    The article discusses the investment level in relation to taxation on the Norwegian continental shelf. Oil companies have put investment of NOK 230 Billions on hold until tax relief is introduced. At least 50% of fields under consideration last August have been downgraded and postponed indefinitely because low prices and high taxes have pushed them below the profitability threshold. 1 fig., 1 tab

  11. The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery.

    Science.gov (United States)

    Blum, Kenneth; Thompson, Benjamin; Demotrovics, Zsolt; Femino, John; Giordano, John; Oscar-Berman, Marlene; Teitelbaum, Scott; Smith, David E; Roy, A Kennison; Agan, Gozde; Fratantonio, James; Badgaiyan, Rajendra D; Gold, Mark S

    There are some who suggest that alcoholism and drug abuse are not diseases at all and that they are not consequences of a brain disorder as espoused recently by the American Society of Addiction Medicine (ASAM). Some would argue that addicts can quit on their own and moderate their alcohol and drug intake. When they present to a treatment program or enter the 12 Step Program & Fellowship, many addicts finally achieve complete abstinence. However, when controlled drinking fails, there may be successful alternatives that fit particular groups of individuals. In this expert opinion, we attempt to identify personal differences in recovery, by clarifying the molecular neurobiological basis of each step of the 12 Step Program. We explore the impact that the molecular neurobiological basis of the 12 steps can have on Reward Deficiency Syndrome (RDS) despite addiction risk gene polymorphisms. This exploration has already been accomplished in part by Blum and others in a 2013 Springer Neuroscience Brief. The purpose of this expert opinion is to briefly, outline the molecular neurobiological and genetic links, especially as they relate to the role of epigenetic changes that are possible in individuals who regularly attend AA meetings. It begs the question as to whether "12 steps programs and fellowship" does induce neuroplasticity and continued dopamine D2 receptor proliferation despite carrying hypodopaminergic type polymorphisms such as DRD2 A1 allele. "Like-minded" doctors of ASAM are cognizant that patients in treatment without the " psycho-social-spiritual trio ," may not be obtaining the important benefits afforded by adopting 12-step doctrines. Are we better off with coupling medical assisted treatment (MAT) that favors combining dopamine agonist modalities (DAM) as possible histone-deacetylase activators with the 12 steps followed by a program that embraces either one or the other? While there are many unanswered questions, at least we have reached a time when "science meets recovery," and in doing so, can further redeem joy in recovery.

  12. Differentiation and Articulation in Tertiary Education Systems : A Study of Twelve African Countries

    OpenAIRE

    Ng'ethe, Njuguna; Subotzky, George; Afeti, George

    2008-01-01

    This study strives to sketch an initial map of the extent and nature of institutional and program differentiation within African systems of tertiary education. In doing so, it also seeks to chart the patterns of articulation that have emerged or been consciously put in place between the different institutional types (such as public universities, private universities, polytechnics, training...

  13. Quantitation of twelve metals in tequila and mezcal spirits as authenticity parameters.

    Science.gov (United States)

    Ceballos-Magańa, Silvia Guillermina; Jurado, José Marcos; Martín, María Jesús; Pablos, Fernando

    2009-02-25

    In this paper the differentiation of silver, gold, aged and extra-aged tequila and mezcal has been carried out according to their metal content. Aluminum, barium, calcium, copper, iron, magnesium, manganese, potassium, sodium, strontium, zinc, and sulfur were determined by inductively coupled plasma optical emission spectrometry. The concentrations found for each element in the samples were used as chemical descriptors for characterization purposes. Principal component analysis, linear discriminant analysis and artificial neural networks were applied to differentiate types of tequila and mezcal. Using probabilistic neural networks 100% of success in the classification was obtained for silver, gold, extra-aged tequila and mezcal. In the case of aged tequila 90% of samples were successfully classified. Sodium, potassium, calcium, sulfur, magnesium, iron, strontium, copper and zinc were the most discriminant elements.

  14. Exploring Content Schemata Influence on L2 Reading: "The Hunted Fox" and "Twelve and Not Stupid"

    Science.gov (United States)

    Radzi, Amizura Hanadi Mohd; Aziz, Noor Hashima Abd

    2014-01-01

    This paper will discuss the aspects of content schemata in second language reading among diploma level students who were taking a reading course in Universiti Teknologi MARA Perlis. In this qualitative case study, the researcher had selected two short stories that are categorized as content-familiar texts, i.e. "The Hunted Fox" and…

  15. Twelve years nuclear medicine - results and outlook - illustrated by 7414 cerebral scintigrams

    International Nuclear Information System (INIS)

    Klaeger, R.

    1981-01-01

    It is a fact that until the invention of computerized tomography, scintiscanning was an excellent method for diagnosing tumours, metastases, vascular processes, inflammations and traumatic lesions. Now even the differential diagnosis is possible, and also follow-up examinations are often carried out. On the basis of the 7414 considered and studied scintigrams we came to the positive result that in most cases with deliberate questions directed to specific facts, this examination procedure was applied. Scintigraphy can be considered as the predecessor of computerized tomography. With respect to differential diagnostics the following can be said: Cerebral scintigraphy measures in cases of cerebral lesions only masses, whereas the computerized tomograph permits within certain limits even the differentiation between lesion and perifocal oedema. The tomographs of the last generation even differentiate between white and grey cerebral substance. Nevertheless, the residual domaine of scintigraphy remains untouched: the patients with non-focal symptoms, including headaches, general behaviour disorders and psychiatric processes. (orig./MG) [de

  16. Macrobenthic Community Structure in the Northwestern Arabian Gulf, Twelve Years after the 1991 Oil Spill

    KAUST Repository

    Joydas, Thadickal V.; Qurban, Mohammad A.; Borja, Angel; Krishnakumar, Periyadan K.; Al-Suwailem, Abdulaziz M.

    2017-01-01

    The biota in the Arabian Gulf faces stress both from natural (i.e., hyper salinity and high sea surface temperature), and human (i.e., from oil-related activities) sources. The western Arabian Gulf was also impacted by world's largest oil spill (1991 Oil Spill). However, benthic research in this region is scarce and most of the studies have been conducted only in small areas. Here, we present data on macrobenthos collected during 2002–2003 from the open waters and inner bays in the northwestern Arabian Gulf aimed to assess the ecological status and also to evaluate the long-term impact, if any, of the 1991 Oil Spill. A total of 392 macrobenthic taxa with an average (±SE) species richness (S) of 71 ± 2, Shannon-Wiener species diversity (H′) of 4.9 ± 0.1, and density of 3,181 ± 359 ind. m−2 was recorded from the open water stations. The open waters have “slightly disturbed” (according to AZTI's Marine Biotic Index, AMBI) conditions, with “good-high” (according to multivariate-AMBI, M-AMBI) ecological status indicating the absence of long-term impacts of the oil spill. Overall, 162 taxa were recorded from inner bays with average (±SE) values of S 41 ± 9, H′ 3.48 ± 0.39, and density 4,203 ± 1,042 ind. m−2. The lower TPH (Total Petroleum Hydrocarbons) stations (LTS, TPH concentrations <70 mg kg−2) show relatively higher S, H' and density compared to the higher TPH stations (HTS, TPH concentrations ≥100 mg kg−2). In the inner bays, AMBI values indicate slightly disturbed conditions at all stations except one, which is moderately disturbed. M-AMBI values indicate good status at LTS, while, high, good, moderate, and poor status at HTS. The “moderately disturbed” conditions with “moderate-poor” ecological status in some locations of the inner bays specify a severe long-term impact of the oil spill.

  17. Twelve Years of Rabies Surveillance in Sri Lanka, 1999–2010

    Science.gov (United States)

    Karunanayake, Dushantha; Matsumoto, Takashi; Wimalaratne, Omala; Nanayakkara, Susilakanthi; Perera, Devika; Nishizono, Akira; Ahmed, Kamruddin

    2014-01-01

    Background Rabies is endemic in Sri Lanka, but little is known about the temporal and spatial trends of rabies in this country. Knowing these trends may provide insight into past control efforts and serve as the basis for future control measures. In this study, we analyzed distribution of rabies in humans and animals over a period of 12 years in Sri Lanka. Methods Accumulated data from 1999 through 2010 compiled by the Department of Rabies Diagnosis and Research, Medical Research Institute (MRI), Colombo, were used in this study. Results The yearly mean percentage of rabies-positive sample was 62.4% (47.6–75.9%). Three-fourths of the rabies-positive samples were from the Colombo, Gampaha, and Kalutara districts in Western province, followed by Galle in Southern province. A high percentage of the rabies samples were from dogs (85.2%), followed by cats (7.9%), humans (3.8%), wild animals (2.0%), and livestock (1.1%). Among wild animals, mongooses were the main victims followed by civets. The number of suspect human rabies cases decreased gradually in Sri Lanka, although the number of human samples submitted for laboratory confirmation increased. Conclusions The number of rabid dogs has remained relatively unchanged, but the number of suspect human rabies is decreasing gradually in Sri Lanka. These findings indicate successful use of postexposure prophylaxis (PEP) by animal bite victims and increased rabies awareness. PEP is free of charge and is supplied through government hospitals by the Ministry of Health, Sri Lanka. Our survey shows that most positive samples were received from Western and Southern provinces, possibly because of the ease of transporting samples to the laboratory. Submissions of wild animal and livestock samples should be increased by creating more awareness among the public. Better rabies surveillance will require introduction of molecular methods for detection and the establishment of more regional rabies diagnostic laboratories. PMID:25299511

  18. Twelve-year mortality in adults initiating antiretroviral therapy in South Africa.

    Science.gov (United States)

    Cornell, Morna; Johnson, Leigh F; Wood, Robin; Tanser, Frank; Fox, Matthew P; Prozesky, Hans; Schomaker, Michael; Egger, Matthias; Davies, Mary-Ann; Boulle, Andrew

    2017-09-25

    South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million HIV-positive South Africans. To ensure that further expansion of services does not compromise quality of care, long-term outcomes must be monitored. Few studies have reported long-term mortality in resource-constrained settings, where mortality ascertainment is challenging. Combining site records with data linked to the national vital registration system, sites in the International Epidemiology Databases to Evaluate AIDS Southern Africa collaboration can identify >95% of deaths in patients with civil identification numbers (IDs). This study used linked data to explore long-term mortality and viral suppression among adults starting ART in South Africa. The study was a cohort analysis of routine data on adults with IDs starting ART 2004-2015 in five large ART cohorts. Mortality was estimated overall and by gender using the Kaplan-Meier estimator and Cox's proportional hazards regression. Standardized mortality ratios (SMRs) were calculated by dividing observed numbers of deaths by numbers expected if patients had been HIV-negative. Viral suppression in patients with viral loads (VLs) in their last year of follow-up was the secondary outcome. Among 72,812 adults followed for 350,376 person years (pyrs), the crude mortality rate was 3.08 (95% CI 3.02-3.14)/100 pyrs. Patients were predominantly female (67%) and the percentage of men initiating ART did not increase. Cumulative mortality 12 years after ART initiation was 23.9% (33.4% male and 19.4% female). Mortality peaked in patients enrolling in 2007-2009 and was higher in men than women at all durations. Observed mortality rates were higher than HIV-negative mortality, decreasing with duration. By 48 months, observed mortality was close to that in the HIV-negative population, and SMRs were similar for all baseline CD4 strata. Three-quarters of patients had VLs in their last year, and 86% of these were virally suppressed. The South African ART programme has shown a remarkable ability to initiate and manage patients successfully over 12 years, despite rapid expansion. With further scale-up, testing and initiating men on ART must be a national priority.

  19. Leaching of Glyphosate and Aminomethylphosphonic Acid from an Agricultural Field over a Twelve-Year Period

    DEFF Research Database (Denmark)

    Norgaard, Trine; Moldrup, Per; Ferré, Ty P A

    2014-01-01

    content at the time of application and the level of the groundwater table relative to the drain depth was essential for whether solutes were detected in the drainage runoff. We present a leaching risk chart to illustrate the dependence of glyphosate, AMPA, and soil particle leaching based on precipitation......, and particles. Glyphosate and AMPA leaching were highly event driven, controlled by the time and intensity of the first precipitation event after glyphosate application. A high similarity in time-accumulated curves for drainage and leached pesticide masses suggests near-constant drainage and leaching rates...

  20. The Pace of Peace on the Viability of Bosnia and Herzegovina Twelve Years after Dayton

    Science.gov (United States)

    2007-06-01

    Martin van Creveld, “Before the State: Prehistory to AD 1300,” in The Rise and Decline of the State (Cambridge University Press, 1999), 1. 12 Yale H...4, no. 1 (March 2005): 58. 55 Kirsti Samuels and Vanessa Hawkins Wyeth, “State-Building and Constitutional Design after Conflict,” IPA Report...who benefit from violent conflict. Spoilers are intrinsically destabilizing. Edward Newman contends that “at the core of this broad definition are

  1. An evaluation of twelve nested models of transperitoneal transport of urea

    DEFF Research Database (Denmark)

    Graff, J; Fugleberg, S; Joffe, P

    1995-01-01

    the mechanism(s) of transperitoneal urea transport and to test the one-compartment assumption for urea. A total of 12 nested models were formulated and validated on the basis of experimental results obtained from 23 non-diabetic patients undergoing peritoneal dialysis. The validation procedure demonstrated...

  2. Depression Risk in Young Adults With Juvenile- and Adult-Onset Lupus: Twelve Years of Followup.

    Science.gov (United States)

    Knight, Andrea M; Trupin, Laura; Katz, Patricia; Yelin, Edward; Lawson, Erica F

    2018-03-01

    To compare major depression risk among young adults with juvenile-onset and adult-onset systemic lupus erythematosus (SLE), and to determine demographic and health-related predictors of depression. Young adults with SLE ages 18-45 years (n = 546) in the Lupus Outcomes Study completed annual telephone surveys from 2002-2015, including assessment of depression using the Center for Epidemiologic Studies Depression Scale (CES-D), and self-report measures of sociodemographics and health characteristics. Juvenile-onset SLE was defined as age adult-onset SLE. Older age, lower educational attainment, and physical function, higher disease activity, and a history of smoking were associated with an increased depression risk. Juvenile-onset SLE patients had a higher risk of major depression across all educational groups. Young adults with SLE, particularly those with juvenile-onset disease, are at high risk for major depression, which is associated with increased disease activity, poorer physical functioning, and lower educational attainment. Early depression intervention in young adults with SLE has the potential to improve both medical and psychosocial outcomes. © 2017, American College of Rheumatology.

  3. Rwanda: a country still in post war syndrome--twelve years later.

    Science.gov (United States)

    Brown, Geraldine

    2006-01-01

    Rwanda, a small country in Central Africa is still trying to survive and rebuild itself some 12 years after the initial deadly war between two ethnic rival groups, the Hutus and the Tutsis. Since my visit in October, 1994, with a handpicked health team (two senior nursing students, an internal medicine physician, social worker, and a nurse volunteer from the District of Columbia community) on a six week mission that was a collaborative effort between Howard University and the Washington, DC based organization, Africare, Inc., very little has happened to better the lives of the citizens. The task at-hand was to assist in the promotion and repairing of a near-fatal health care delivery system, that occurred just six months after the major attack in April. Rwanda experienced a war, noted as the most brutal in the memory of the country, that killed so many people and destroyed so much of the country and its resources. Since our mission, so much has been written and new concerns have surfaced such as "Hotel Rwanda", a million dollar plus movie that truthfully tells the story of how a real-life person actually saved some 1,200 countrymen in what is carefully termed a "genocide", and the book "Left to Tell", written by a female Tutsi survivor, Immaculee Ilibagiza tells the story of how she survived the genocide and discovered that "with God all things are possible." This present article has attempted to discuss the genocide and how it relates, bringing a connection from within the inner world to the outer world through my experience of "having been there and done that" as seen by the naked human eyes.

  4. Twelve Years Since Importance of Cross-Cultural Competency Recognized: Where Are We Now?

    Science.gov (United States)

    Kessler, Remi A; Coates, Wendy C; Chanmugam, Arjun

    2017-02-01

    The objective of this study was to analyze the content and volume of literature that has been written on cultural competency in emergency medicine (EM) since its educational imperative was first described by the Institute of Medicine in 2002. We conducted a comprehensive literature search through the PubMed portal in January 2015 to identify all articles and reviews that addressed cultural competency in EM. Articles were included in the review if cultural competency was described or if its impact on healthcare disparities or curriculum development was described. Two reviewers independently investigated all relevant articles. These articles were then summarized. Of the 73 abstracts identified in the initial search, only 10 met criteria for inclusion. A common theme found among these 10 articles is that cultural competency in EM is essential to reducing healthcare disparities and improving patient care. These articles were consistent in their support for cross-cultural educational advancements in the EM curriculum. Despite the documented importance of cultural competency education in medicine, there appears to be only 10 articles over the past 12 years regarding its development and implementation in EM. This comprehensive literature review underscores the relative dearth of publications related to cultural competency in EM. The limited number of articles found is striking when compared to the growth of EM research over the same time period and can serve as a stimulus for further research in this significant area of EM education.

  5. Radio emission from supernovae. I. One to twelve year old supernovae

    International Nuclear Information System (INIS)

    Weiler, K.W.; Panagia, N.; Sramek, R.A.; Van Der Hulst, J.M.; Roberts, M.S.

    1989-01-01

    All recorded optical supernovae brighter than 14.0 mag from SN 1970A to SN 1981A were observed in May 1982 using VLA at 6 cm. Apart from the known radio supernovae (SN 1970G, SN 1979C, and SN 1980K), radio emissions were not detected from any of the objects to a limit of about 0.5 mJy. Limits on mass-loss rates from the presupernova systems are established. It is found that Type Ia Sns originate in systems which contain very little circumstellar material at the time of explosion. These systems are very different from those which originate Type Ib Sns. With some exceptions, Type II SNs originate with the high presupernova mass-loss rates expected from red supergiant progenitors with original main-sequence masses greater than about 8 solar masses. 16 references

  6. The relationship between twelve-month home stimulation and school achievement.

    Science.gov (United States)

    van Doorninck, W J; Caldwell, B M; Wright, C; Frankenburg, W K

    1981-09-01

    Home Observation for Measurement of the Environment (HOME) was designed to reflect parental support of early cognitive and socioemotional development. 12-month HOME scores were correlated with elementary school achievement, 5--9 years later. 50 low-income children were rank ordered by a weighted average of centile estimates of achievement test scores, letter grades, and curriculum levels in reading and math. 24 children were classified as having significant school achievement problems. The HOME total score correlated significantly, r = .37, with school centile scores among the low-income families. The statistically more appropriate contingency table analysis revealed a 68% correct classification rate and a significantly reduced error rate over random or blanket prediction. The results supported the predictive value of the 12-month HOME for school achievement among low-income families. In an additional sample of 21 middle-income families, there was insufficient variability among HOME scores to allow prediction. The HOME total scores were highly correlated, r = .86, among siblings tested at least 10 months apart.

  7. Eight- and twelve-hour shifts in Austrian rail traffic controllers: a psychophysiological comparison

    Directory of Open Access Journals (Sweden)

    K. WOLFGANG KALLUS

    2009-09-01

    Full Text Available The present study compared a 12-hour and an 8-hour shift system in 18 Austrian rail traffic controllers. To gain objective indicators for arousal and fatigue induced by the whole workrest sequence, we recorded heart rate during the last night shift, in addition to subjective measures that included physical symptoms. A higher increase of monotony, fatigue and saturation emerged during the 8-hour compared to the 12-hour regime, together with a heart rate decrease during the last 8-hour night shift. In line with other researchers, we conclude that flexible working conditions in specific occupational groups may compensate for disadvantages of prolonged working periods, giving way to advantages of longer shifts such as longer pauses and extra days off for social and other personal activities.

  8. Handbook for Instruction on Aging in California Public Schools. Kindergarten Through Grade Twelve.

    Science.gov (United States)

    California State Dept. of Education, Sacramento.

    This handbook is designed to assist teachers at the elementary and secondary level in the development of curricula on aging which can integrate the concepts of aging into ongoing lesson plans. The five content areas of instruction include chronological aging, physiological and biological aging, sociocultural aspects of aging, psychological aging,…

  9. Screening of crude extracts of twelve medicinal plants and “wonder ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-09-17

    Sep 17, 2008 ... 1/7 of all deaths in Europe and 1/3 of deaths among productive ... death worldwide killing 2 million people each year. (Frieden et al. ... powder), whole scorpion (powdered) and poisonous rat. (powdered). ... weeks before use.

  10. Twelve years of continuous measurements of atmospheric electrical activity in Mexico's Tropical highland

    Energy Technology Data Exchange (ETDEWEB)

    Troncoso Lozada, O. [Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico (UNAM), Mexico, D.F. (Mexico)

    2004-04-01

    Atmospheric electric activity measurements have been recorded continuously by a punctual lightning system at a tropical highland observatory from 1988 onwards, and were analyzed to obtain lightning statistical confident results for thunderstorms occurrence on the leeward side of the southern mountain ridge of Mexico's Valley. Shown, as examples, are individual profiles of the atmospheric electrical activity, associated with severe storms. The results make clear that the fastest possible sequence of electrical measurements is required to obtain significant and applications oriented data in connection with a whole series of thunderstorms taking into account the mean time variation of the atmospheric electricity measurements at an altitude of 2270 m a.s.l. The seasonal variation indicates that the lightning flash peak currents were found to be larger in summer with less than 10% occurring in the autumn and winter. With rainfall data from a network of 66 stations, we obtained a significant correlation with the lightning frequency. Special attention was undertaken concerning the question of the atmospheric electrical activity and climate at Valley of Mexico. [Spanish] Se midieron ininterrumpidamente las variaciones de la actividad electrica en la atmosfera, de enero de 1988 a diciembre de 1999, en un observatorio de altura (2,250 m s.n.m.), y se analizaron para obtener resultados estadisticos confiables con relacion a la ocurrencia de tormentas en la region sur del Valle de Mexico. Como ejemplos, se muestran los perfiles individuales de la actividad electrica atmosferica asociada con tormentas severas. Los resultados dejan claro que se requiere de la secuencia de medidas electricas lo mas rapida posible para obtener datos significativos y aplicables en relacion con una serie completa de tormentas, considerando la media del tiempo de variacion de las mediciones de la actividad electrica atmosferica a una altitud de 2,270 m s.n.m. La validacion estacional indica que la mayor actividad de tormentas electricas se produce en el verano, con menos de 10% en otono e invierno. Se obtuvo una correlacion significativa entre los datos de precipitacion de una red de 66 estaciones y la frecuencia de descargas. Se dio especial atencion a la cuestion de la actividad electrica atmosferica y el clima en el Valle de Mexico.

  11. Visual And Performing Arts Framework For California Public Schools: Kindergarten through Grade Twelve

    Science.gov (United States)

    California State Department of Education, 2004

    2004-01-01

    This framework is designed to help classroom teachers and other educators develop curriculum and instruction in the arts so that all students will meet or exceed the content standards in dance, music, theatre, and the visual arts. In chapter 1, the framework presents guiding principles for instruction in dance, music, theatre, and the visual arts.…

  12. VARIATION IN BIOFUEL POTENTIAL OF TWELVE CALOPYLLUM INOPHYLLUM POPULATIONS IN INDONESIA

    OpenAIRE

    Leksono Budi; Laksmi Hendrati Rina; Windyarini Eritrina; Hasnah Trimaria

    2014-01-01

    The global energy crisis has raises demand for biofuel prices. It has driven the world to enhance environmentally-friendly renewable-energy (biofuel) production. Oil from the seeds of Calophyllum inophyllum (nyamplung) which can be harvested up to 50 years, is one of  such potential biofuel source. Methods for biofuel production from nyamplung seeds have been developed at an industrial scale by cooperative in Cilacap (Java) and Energy Self-Sufficient Villages (Desa Mandiri Energi) in Banyuwan...

  13. Teenage Mothers' Anger over Twelve Years: Partner Conflict, Partner Transitions and Children's Anger

    Science.gov (United States)

    Jenkins, Jennifer M.; Shapka, Jennifer D.; Sorenson, Ann M.

    2006-01-01

    Background: This study examined the effects of maternal anger, partner transitions and partner conflict on later oppositional and angry behavior of the children of teenage mothers. Methods: One hundred and twenty-one teenage women were interviewed prior to the birth of the baby and at 3 points subsequently, when children were newborn, 7 years old…

  14. Macrobenthic Community Structure in the Northwestern Arabian Gulf, Twelve Years after the 1991 Oil Spill

    Directory of Open Access Journals (Sweden)

    Thadickal V. Joydas

    2017-08-01

    Full Text Available The biota in the Arabian Gulf faces stress both from natural (i.e., hyper salinity and high sea surface temperature, and human (i.e., from oil-related activities sources. The western Arabian Gulf was also impacted by world's largest oil spill (1991 Oil Spill. However, benthic research in this region is scarce and most of the studies have been conducted only in small areas. Here, we present data on macrobenthos collected during 2002–2003 from the open waters and inner bays in the northwestern Arabian Gulf aimed to assess the ecological status and also to evaluate the long-term impact, if any, of the 1991 Oil Spill. A total of 392 macrobenthic taxa with an average (±SE species richness (S of 71 ± 2, Shannon-Wiener species diversity (H′ of 4.9 ± 0.1, and density of 3,181 ± 359 ind. m−2 was recorded from the open water stations. The open waters have “slightly disturbed” (according to AZTI's Marine Biotic Index, AMBI conditions, with “good-high” (according to multivariate-AMBI, M-AMBI ecological status indicating the absence of long-term impacts of the oil spill. Overall, 162 taxa were recorded from inner bays with average (±SE values of S 41 ± 9, H′ 3.48 ± 0.39, and density 4,203 ± 1,042 ind. m−2. The lower TPH (Total Petroleum Hydrocarbons stations (LTS, TPH concentrations <70 mg kg−2 show relatively higher S, H' and density compared to the higher TPH stations (HTS, TPH concentrations ≥100 mg kg−2. In the inner bays, AMBI values indicate slightly disturbed conditions at all stations except one, which is moderately disturbed. M-AMBI values indicate good status at LTS, while, high, good, moderate, and poor status at HTS. The “moderately disturbed” conditions with “moderate-poor” ecological status in some locations of the inner bays specify a severe long-term impact of the oil spill.

  15. Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Wang Jue

    2011-11-01

    Full Text Available Abstract Background Metastatic renal cell carcinoma (RCC presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy. Patients and Methods We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patinet subsequently had multiple tumor recurrences. Results The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis. Conclusion Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.

  16. Key lessons — Twelve factors critical to the success of WDM at the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-12-22

    Dec 22, 2010 ... Water demand management (WDM) programs have been widely ... The criteria below are intended to help policymakers determine how best to ... implement and monitor WDM activities and to further the concept of WDM as ...

  17. Operating the plant, quality assurance, and the job of the operating staff, Volume Twelve

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Subject matter includes operating the plant (the role of the operator, the control room, plant technical specifications, plant operating procedures, initial startup program, BWR/PWR plant startup, BWR/PWR steady state power operation, BWR/PWR transient operation, emergency operation), quality assurance (what is quality, what is quality control, quality assurance includes quality control, government regulation and quality assurance, administrative controls for nuclear power plants, the necessity of reviews and audits, practical quality assurance), and the job of the operating staff (the plant operating staff, plant safety, first aid and resuscitation, general plant hazards, personnel protective equipment, handling chemicals, handling compressed gas, equipment repair and maintenance, communicating with others

  18. Comparison of outcomes twelve years after antireflux surgery or omeprazole maintenance therapy for reflux esophagitis

    DEFF Research Database (Denmark)

    Lundell, Lars; Miettinen, Pekka; Myrvold, Helge E

    2009-01-01

    with esophagitis enrolled from outpatient clinics in Nordic countries. Of the 155 patients randomly assigned to each arm of the study, 154 received omeprazole (1 withdrew before therapy began), and 144 received surgery (11 withdrew before surgery). In patients who remained in remission after treatment, post....... Heartburn and regurgitation were significantly more common in patients given omeprazole, whereas dysphagia, rectal flatulence, and the inability to belch or vomit were significantly more common in surgical patients. The therapies were otherwise well-tolerated. CONCLUSIONS: As long-term therapeutic...

  19. Persistent quantum-size effect in aluminum films up to twelve atoms thick

    International Nuclear Information System (INIS)

    Boettger, J.C.

    1996-01-01

    Total energies and work functions have been calculated for unrelaxed, free-standing Al(111) films, 1 endash 12 layers thick, using the all-electron, full-potential linear combination of Gaussian-type orbitals endash fitting-function technique. The work function exhibits a significant quantum-size effect (at least 0.1 eV) over the entire range of thickness considered. This result contradicts an old prediction that the work function of an Al(111) N-layer film will converge to within a few hundredths of an eV by N=6. The present result, which is consistent with earlier jellium calculations, demonstrates the risk of mistaking an accidental coincidence of work functions for two films, differing in thickness by one layer, for a true convergence with respect to thickness. The implications for thin-film calculations of surface properties are discussed. A linear fit to the film binding energy vs thickness is used to extract the Al(111) surface energy (0.45 eV) and the binding energy of bulk Al (4.06 eV). copyright 1996 The American Physical Society

  20. The Frequency of Occurrence of Air Masses Over Twelve European Cities.

    Science.gov (United States)

    1983-01-01

    cluster analysis technique to investigate the possibility of simplifying the European "",Oskar Essermanger, 1954, Neue Methode der Zerleang von...Masses, Streamlines, and the Boreal Forest," Geographical Bulletin, Vol 8 11 J. M. Davis, 1981, The Use of Cluster Analysis in the Identification and...Atmosphere and a Proposed Model for Frontal Analysis," Tellus, Vol 5 ’’N. S. McDonald, 1975, "Etgenvectur Analisis as an Aid to Air Mass Recognition

  1. Twelve-lead electrocardiography in the young: physiologic and pathologic abnormalities.

    Science.gov (United States)

    Kobza, Richard; Cuculi, Florim; Abächerli, Roger; Toggweiler, Stefan; Suter, Yves; Frey, Franz; Schmid, Johann Jakob; Erne, Paul

    2012-12-01

    BACKGROUND/ OBJECTIVE: The purpose of the present study was to analyze the prevalence of physiologic and pathologic ECG abnormalities in a cohort of young conscripts that represents the whole young generation of today. ECGs of all Swiss citizens who underwent conscription for the army during a 29-month period were analyzed manually. ECGs of 43,401 conscripts (mean age 19.2 ± 1.1 years) were analyzed; 158 conscripts were female. Incomplete right bundle branch block was found in 5870 (13.5%) and left anterior fascicular block in 360 (0.83%). First-degree AV block was present in 329 (0.8%) and Mobitz type I (Wenckebach) second-degree AV block in 3 (0.01%). Early repolarization was observed in 1035 (2.4%), T-wave inversion in 39 (0.09%), and minor T-wave changes in 182 (0.42%). Brugada-like abnormalities were observed in 6 (0.01%). None of the conscripts had atrial fibrillation or flutter. ECG abnormalities can be found in a relatively large proportion of young individuals. Incomplete right bundle branch block, left fascicular block, and first-degree AV block are the most frequent findings. No conscript presented with atrial fibrillation or flutter. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  2. EXERCISE LIMITATIONS IN A COMPETITIVE CYCLIST TWELVE MONTHS POST HEART TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    Nicolas G. Walton

    2009-12-01

    Full Text Available It has been well documented that for heart transplant recipients (HTrecipient post transplantation exercise capacity does not exceed 60% of healthy age-matched controls. Few studies have been undertaken to determine the cause of exercise limitations following heart transplantation (HT for an elite athlete. Participant was a 39 year old elite male cyclist who suffered an acute myocardial infarction after a cycling race and received a heart transplant (HT four months later. Six weeks prior to his AMI fitness testing was completed and a predicted VO2max of 58 mL·kg-1·min-1 and HRmax of 171 bpm was achieved. The participant underwent maximal exercise testing 6 and 12 months post transplant to determine exercise limitations. His results 6 and 12 months post transplant were a VO2max of 33.8 and 44.2 mL·kg-1·min-1 respectively, and a HR max that was 97% and 96% of HRmax measured. The participant showed an increase in both HRmax and VO2max 12 months post HT compared to previous testing. Results suggest that the limiting factors to exercise following HT are likely due to peripheral function, which became diminished as a result accumulated from 4 months of congestive heart failure, the strain of HT, and immunosuppressive therapy leading up to the exercise testing. Lifestyle before HT and a more aggressive approach to HT recovery should be considered necessary in the improvement of peripheral functioning following HT

  3. Twelve automated thresholding methods for segmentation of PET images: a phantom study

    International Nuclear Information System (INIS)

    Prieto, Elena; Peñuelas, Iván; Martí-Climent, Josep M; Lecumberri, Pablo; Gómez, Marisol; Pagola, Miguel; Bilbao, Izaskun; Ecay, Margarita

    2012-01-01

    Tumor volume delineation over positron emission tomography (PET) images is of great interest for proper diagnosis and therapy planning. However, standard segmentation techniques (manual or semi-automated) are operator dependent and time consuming while fully automated procedures are cumbersome or require complex mathematical development. The aim of this study was to segment PET images in a fully automated way by implementing a set of 12 automated thresholding algorithms, classical in the fields of optical character recognition, tissue engineering or non-destructive testing images in high-tech structures. Automated thresholding algorithms select a specific threshold for each image without any a priori spatial information of the segmented object or any special calibration of the tomograph, as opposed to usual thresholding methods for PET. Spherical 18 F-filled objects of different volumes were acquired on clinical PET/CT and on a small animal PET scanner, with three different signal-to-background ratios. Images were segmented with 12 automatic thresholding algorithms and results were compared with the standard segmentation reference, a threshold at 42% of the maximum uptake. Ridler and Ramesh thresholding algorithms based on clustering and histogram-shape information, respectively, provided better results that the classical 42%-based threshold (p < 0.05). We have herein demonstrated that fully automated thresholding algorithms can provide better results than classical PET segmentation tools. (paper)

  4. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    OpenAIRE

    Voight, Benjamin; Scott, Laura; Steinthorsdottir, Valgerdur; Morris, Andrew; Dina, Christian; Welch, Ryan; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii; Thorleifsson, Gudmar; McCulloch, Laura; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming

    2010-01-01

    textabstractBy combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of ov...

  5. Single Jejunum Metastasis from Breast Cancer Arising Twelve Years after the Initial Treatment

    Directory of Open Access Journals (Sweden)

    Cláudia Paiva

    2016-01-01

    Full Text Available Metastatic involvement of gastrointestinal tract from breast cancer is a rare event. We report the case of a 61-year-old woman presenting with bowel obstruction, related to metastasis of a primary breast cancer she had 12 years earlier (a triple-negative invasive ductal carcinoma treated with surgery and chemotherapy. Bowel obstruction was caused by a 20-centimeter tumor in the jejunum, involving also the transverse colon. The patient underwent en bloc resection of tumor with jejunum and transverse bowel segment and received adjuvant chemotherapy with carboplatin and paclitaxel. Twenty months later, she was alive without disease recurrence.

  6. Twelve tips for applying change models to curriculum design, development and delivery.

    Science.gov (United States)

    McKimm, Judy; Jones, Paul Kneath

    2017-10-25

    Drawing primarily from business and management literature and the authors' experience, these 12 tips provide guidance to organizations, teams, and individuals involved in curriculum or program development at undergraduate, postgraduate, and continuing education levels. The tips are based around change models and approaches and can help underpin successful curriculum review, development, and delivery, as well as fostering appropriate educational innovation. A range of tools exist to support systematic program development and review, but even relatively simple changes need to take account of many factors, including the complexity of the environment, stakeholder engagement, cultural and psychological aspects, and the importance of followers.

  7. Salvage whole abdominal radiation therapy for ovarian cancer: a twelve year experience

    International Nuclear Information System (INIS)

    Baker, Katherine; Reddy, Susheel; Lee, Myung-Sook; Geest, Koen de; Lincoln, Sarah; Sarin, Pramilla; Graham, James; Yordan, Edgardo; Reddy, Salitha

    1996-01-01

    Purpose: 1) To evaluate whole abdominal radiation therapy (WART) as a salvage modality in patients with epithelial ovarian carcinoma who have failed one or more chemotherapeutic regimens; 2) To assess the feasibility and long-term toxicity of such treatment. Materials and Methods: Between June 1983 and October 1994, 51 patients who had failed one or more chemotherapeutic regimens received WART. Forty-seven patients had epithelial ovarian carcinoma, the remaining had primary carcinoma of the peritoneal cavity. Forty patients (78%) had FIGO stage III and IV disease. Grade III and IV tumors were seen in 29 patients (57%). The residual disease was classified as being either microscopic or macroscopic disease depending on the status after the laparotomy prior to radiation treatment, irrespective of the extent of disease prior to debulking. In 22 patients (43%) macroscopic disease was present after laparotomy, while the remaining 29 patients (57%) had only microscopic disease present. Twenty patients (39%) had residual disease limited to the pelvis, and 31 patients (61%) had upper abdominal involvement. An open field technique was used to deliver planned doses of 25Gy to the whole abdomen with shielding of the kidneys posteriorly after 12Gy. Boost fields to the pelvis and/or areas of gross residual disease were treated when indicated. The Kaplan-Meier Method was used to calculate survival data from the initiation of radiation until death or recurrence. Median follow-up for surviving patients was 53 months, with a range of 17 to 122 months. Results: Five patients (10%) were unable to complete therapy secondary to acute toxicity. An additional fourteen patients (27%) required a one to five week break usually secondary to cytopenias. Four year actuarial survival and recurrence-free survival rates for the entire group of patients were 32% and 23% respectively. For patients with microscopic residual disease, survival and recurrence-free survival rates were 48% and 37% respectively. This is better than the actuarial survival of 11% and the recurrence-free survival of 5% in patients with macroscopic residual disease. Those patients with disease limited to the pelvis after laparotomy had a 4 year actuarial survival and recurrence-free survival of 60% and 54% respectively. Conversely, when upper abdominal involvement was present survival and recurrence-free survival were 16% and 4% respectively. Log rank tests were done to compare overall survival (OS) and recurrence-free survival (RFS) in specific groups of patients. Statistically significant differences were seen with respect to microscopic versus macroscopic disease remaining after laparotomy (OS p = .0001, RFS p .0001), and pelvic disease only versus abdominal disease (OS p = .0019, RFS p = .0002). Ten patients (20%) experienced bowel complications of whom six patients (12%) required surgical intervention. Two patients developed leukemia and one patient developed myelodysplastic syndrome. Conclusion: Whole abdominal radiation therapy is an effective salvage treatment in patients with ovarian carcinoma who have microscopic residual disease or disease limited to the pelvis. The treatment is well tolerated with acceptable long-term toxicity

  8. Heath Effects Sequence of Meet Halfa Radiological Accident After Twelve Years

    International Nuclear Information System (INIS)

    Shabon, M.H.

    2013-01-01

    The accident of Meet-Halfa developed consequent upon the loss of an industrial gamma radiography source. The source was found by a farmer resident of Meet-Halfa who took it to his house occupied by his family. The sequence of events developed over a period of seven weeks from the time the source was found on May 5, 2000, till the day of its retrieval from the house by the national authorities on June 26. The protracted exposure patterns of the family members during the period of source possession are not precisely known, however these exposures resulted in two fatalities, clinical forms of bone marrow depression, and several skin burns of different severities. The recent sequences of the accident is as follows:-The three survived siblings married and get good children. That mean there is no hereditary stochastic effects. The sister died at 2007 with 72 years old with senility and no specific disease. The youngest daughter amputate the left thumb and index fingers at 2001. The elder son amputate the terminal phalanx of the right thumb at 2009. The youngest daughter amputate the right index finger at 2009. The elder son graft the burn at the lower right quadrant of the abdomen for more than 20 times (3 of them were in the Mansheat Al-Bakry Millitary Hospital), but there is residual of burn untill now. Sever abdominal hernia in the elder son due to necroses in the right quadrant abdominal muscles. Grafting for these muscles occur but failed.

  9. Retrospective study comparing six - and twelve-core prostate biopsy in detection of prostate cancer

    Directory of Open Access Journals (Sweden)

    Motoi Tobiume

    2008-02-01

    Full Text Available OBJECTIVE: We compared the safety and efficacy of the 12-core biopsy with those of the conventional systematic 6-core biopsy with PSA levels between 4.1 and 20.0 ng/mL. MATERIALS AND METHODS: This study included 428 patients who underwent a 6-core biopsy and 128 patients who underwent a 12-core biopsy. Biopsies were performed transrectally under ultrasound guidance. The 12-core biopsy scheme involved obtaining 6 far lateral cores. RESULTS: For patients with PSA level between 4.1 and 10.1 ng/mL, 47 of the 265 patients who underwent 6-core biopsy and 32 of the 91 patients who underwent a12-core biopsy were diagnosed with prostate cancer (p = 0.0006. Among the patients with a PSA level between 10.1 and 20.0 ng/mL, 48 of 163 patients who underwent the 6-core biopsy and 16 of 37 patients who underwent the 12-core biopsy were diagnosed with prostate cancer (p = 0.0606. Three of the 95 patients who were diagnosed with prostate cancer through the 6-core biopsy and 12 of the 48 patients who were diagnosed through the 12-core biopsy had cancer located in the anterior apex. The 12-core biopsy increased the diagnostic rate in the apex (p = 0.001. No statistically significant differences were found in incidence of complications. CONCLUSION: We concluded that the 12-core biopsy is a safe and more effective procedure for increasing the diagnostic rate of prostate cancer than the 6-core biopsy in patients with PSA level between 4.1 and 10.0 ng/mL, and the most useful anatomical area to be added was found to be cores from the anterior apex.

  10. Relationship transitions and change in health behavior: A four-phase, twelve-year longitudinal study.

    Science.gov (United States)

    Josefsson, Kim; Elovainio, Marko; Stenholm, Sari; Kawachi, Ichiro; Kauppi, Maarit; Aalto, Ville; Kivimäki, Mika; Vahtera, Jussi

    2018-03-19

    Extensive scientific evidence shows an association between involvement in social relationships and healthy lifestyle. Prospective studies with many participants and long follow-ups are needed to study the dynamics and change in social factors within individuals over time. Our aim was to determine whether a change in relationship status (single, married, divorced, widow, cohabiting) is followed by a change in health behavior (smoking, alcohol consumption, physical activity, and body mass index). We used data from 81,925 healthy adults participating in the prospective longitudinal Finnish Public Sector Study in the period 2000-2013. We analyzed 327,700 person-observations from four data collection phases. Missing data were multiply imputed. A within-individual methodology was used to minimize the possibility of selection effects affecting the interpretation. All four health behaviors showed associations with relationship status. The effects were very similar and in the same direction in women and men, although there were gender differences in the magnitudes of the effects. The end of a relationship was followed by a decrease in body mass index, increased odds of being a smoker, increase in physical activity, and increase in alcohol consumption (widowed men). The effects were reverse when forming a new relationship. A change in relationship status is associated with a change in health behavior. The association is not explained by socioeconomic status, subjective health status, or anxiety level. People leaving or losing a relationship are at increased risk of unhealthy behavior (smoking and alcohol consumption), but at the same time they have a lower BMI and show higher physical activity compared to the time they were in a relationship. It is not clear if the cumulative health effect of these health behavior changes is positive or negative. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Dvylikos Olimpo dievų vaizdavimas Enijaus Analuose. Depiction of twelve Olympian gods in Ennius’ Annales

    Directory of Open Access Journals (Sweden)

    Tomas Veteikis

    2008-01-01

    Full Text Available Annales of Ennius, partly aimed at survey of Roman history year by year, partly at memorizing Roman heroes and equating them to gods, though had a few antecedant models in Hellenistic epic, remains unrivalled in respect of vastitude and bravery of the innovatory devise. The poem, praising deeds of Roman god-like ancestors, kings, consuls and tribunes, had certain political aspirations tending to melt the scepticism towards Greek culture and its reception among conservative members of aristocracy of Ennius’ time. On the other hand, being performed in traditional Roman convivial setting, Annales were in accord with Roman piety and reverent attitude towards gods, whence poet’s aim at his own otherness and impartiality might be discerned.Annales of Ennius not only reminds its readers of Roman strategy of gaining over Carthaginian or Greek deities during Roman expansion outside Appenines, but also claims their common identity with Roman gods, whence the idea of Greek and Roman cultural affinity and common genealogy comes. This idea most probably originates from the deep consideration of homeric and hellenistic epic and their exegetical traditions combined with other philosophical views (even contrasting ones attainable in III B. C. Italy. However, the state of extant text of Annales, consisting of over 600 fragmentary verses (plus around 100 more or less identified testimonia together with recently deciphered fragments from Herculanean papyrus, doesn’t provide us with certain argument what attitude in Ennius’ notion prevailed, unless we investigate one by one all the mentions of gods in this poem. The complex task is treated in this article in a selective manner: the main attention is paid only to the limited part of over 40 deities present in Annales, namely, to the Greco-Roman dodekatheon or di consentes, most clearly attested in Ann. 240–241 Sk. The method of investigation rests on the description of each deity separately, both trying to establish the most characteristical features of each in Ennian depiction and compare with the evidence of his / her contemporary cult and degree of syncretization.In the course of analysis, a somewhat parallel attempt is also made to verify Cicero’s message concerning Ennius’ belief in gods in general (Div. 1, 58. The analysis shows quite divergent result resting upon incomplete status of our sources: some gods are depicted as participants of human actions, some remain mere vague representatives of natural phenomena.The bulk of conclusions deals with national dependance, hierarchy and stylistic variation of Ennius’ dodekatheon. Material of this paper clearly indicates the national priority in Annales: the most honoured both statistically and virtually are the four ancestral Roman gods (di genitales – Juppiter, Juno, Venus and Mars. Each of them also appears in certain non-Roman context (Trojan, Greek, Carthaginian or Sabinian, where their Roman priority is not emphasized, unless their Latin name is taken into account. The latter fact combined with Ennian technics of Homer’s imitation and hellenistic erudition enables him to rewrite ancient history from the Roman point. This actually happens on the theological level when Roman state gods become continuators of variously reinterpreted homeric greco-trojan gods. Annals of Ennius thus attest the absorbtion of Greek Olympic pantheon into Roman state pantheon. Depiction of gods in the poem also has certain “expurgatory” mark, since very few traces of obscenity in gods’ portrayal are present (with exception of Mars, called homo pulcer with possibly euhemeric hint. On the other hand, the sublimity of Ennian gods is moderate: there are several indications of their humanly sensitive and not indifferent stance in their contacts with people (esp. Juno, Juppiter and Venus.A considerable group of Olympian gods in the current fragmentary shape of Annals remains not clearly presented: some produce no material for deeper analysis (e. g. Diana and Ceres, some appear only in the metonymic use (Neptune, Volcanus, others could be characterized on the ground of mere indirect reference to their ritual elements, mythological or allegorical identity (Vesta, Minerva, Mercurius. Permanent attention to universal aspects, esp. to the mysthic and prophetic ones (Minerva, Apollo, Muses, and avoidance of “undignified” features show perhaps definite poet’s attitude and support modern view of Ennius’ both honorable and impartial position towards Roman “political Olympus”.

  12. Twelve essential tools for living the life of whole person health care.

    Science.gov (United States)

    Schlitz, Marilyn; Valentina, Elizabeth

    2013-01-01

    The integration of body, mind, and spirit has become a key dimension of health education and disease prevention and treatment; however, our health care system remains primarily disease centered. Finding simple steps to help each of us find our own balance can improve our lives, our work, and our relationships. On the basis of interviews with health care experts at the leading edge of the new model of medicine, this article identifies simple tools to improve the health of patients and caregivers.

  13. Twelve tips for assessing surgical performance and use of technical assessment scales

    DEFF Research Database (Denmark)

    Strandbygaard, Jeanett; Scheele, Fedde; Sørensen, Jette Led

    2017-01-01

    Using validated assessment scales for technical competence can help structure and standardize assessment and feedback for both the trainee and the supervisor and thereby avoid bias and drive learning. Correct assessment of operative skills can establish learning curves and allow adequate monitoring....... However, the assessment of surgical performance is not an easy task, since it includes many proxy parameters, which are hard to measure. Although numerous technical assessment scales exist, both within laparoscopic and open surgery, the validity evidence is often sparse, and this can raise doubts about...... reliability and educational outcome. Furthermore, the implementation of technical assessment scales varies due to several obstacles and doubts about accurate use. In this 12-tips article, we aim to give the readers a critical and useful appraisal of some of the common questions and misunderstandings regarding...

  14. Characterization and evaluation of catechol oxygenases by twelve bacteria, isolated from oil contaminated soils in Malaysia

    Directory of Open Access Journals (Sweden)

    Arezoo Tavakoli

    2017-01-01

    Full Text Available Introduction: Catechol is a common intermediate compound in aromatic degradation process. Some microorganisms have this potentiality to degrade aromatic hydrocarbons by catechol dioxygenases to less toxic compounds with ability of entering the tricarboxylic acid cycle. In the present study, the catechol oxygenase activity was measured for 12 crude oil degrader bacteria. Materials and methods: Catechol oxygenase activity of two enzymes includes catechol 1, 2 dioxygenase and catechol 2, 3 dioxygenase were determined using spectrophotometer at 260 nm and 375 nm, respectively. Results: The highest enzyme activity for catechol 1, 2 dioxygenase by Bacillus cereus UKMP-6G was (0.07 U/mL and about catechol 2, 3 dioxygenase was 0.031 U/mL by Rhodococcus ruber UKMP-5M during the first minute of incubation. Catechol 1, 2 dioxygenase and catechol 2, 3 dioxygenase followed the ortho and meta pathway, respectively. Discussion and conclusion: The enzyme assay results showed that among 12 examined bacteria, only R. ruber UKMP-5M has the ability to use meta pathway for degradation and produce 2-hydroxymuconic acid. The other isolates use ortho pathway and create cis, cis-muconic acid.

  15. Twelve years of coccidioidomycosis in Ceará State, Northeast Brazil: epidemiologic and diagnostic aspects.

    Science.gov (United States)

    Cordeiro, Rossana de Aguiar; Brilhante, Raimunda Sâmia Nogueira; Rocha, Marcos Fábio Gadelha; Bandeira, Silviane Praciano; Fechine, Maria Auxiliadora Bezerra; de Camargo, Zoilo Pires; Sidrim, José Júlio Costa

    2010-01-01

    Coccidioidomycosis is an endemic infection in the Americas caused by the dimorphic fungi Coccidioides immitis and Coccidioides posadasii. Although the disease occurs in Brazil in sporadic form, little information about these cases is available. In this study, we summarize the most important clinical, epidemiologic, and diagnostic features of coccidioidomycosis in Ceará State (Northeast Brazil) during the past 12 years. In this period, 19 cases of coccidioidomycosis were diagnosed. All the patients were young males and came from semiarid areas of the state. The majority of cases were associated to armadillo hunting, and pulmonary disease was the most common clinical presentation. In our laboratory, coccidioidomycosis was confirmed by culture, serology, and polymerase chain reaction tests, which together were very suitable for the diagnosis of this disease. Based on our local experience, we believe many cases of this disease are misdiagnosed or not diagnosed in our region. Therefore, some strategies for improvement of diagnosis should be encouraged by local authorities.

  16. Comparing twelve-lead electrocardiography with close-to-heart patch based electrocardiography

    DEFF Research Database (Denmark)

    Hansen, Ingeborg Helbech; Hoppe, Karsten; Gjerde, Anna

    2015-01-01

    used in the clinic impeding clinical interpretation. In this study, recordings from an ePatch® lead system involving three torso sites are compared with concurrently recorded standard 12-lead ECG. Pearson's correlation coefficients (CC) of −0.90 and 0.91 is found between two of the PEM signals...

  17. Twelve months follow-up after retrograde recanalization of superficial femoral artery chronic total occlusion

    Directory of Open Access Journals (Sweden)

    Joanna Wojtasik-Bakalarz

    2017-03-01

    Full Text Available Introduction : Fifty percent of cases of peripheral artery disease are caused by chronic total occlusion (CTO of the superficial femoral artery (SFA. Ten–fifteen percent of percutaneous SFA recanalization procedures are unsuccessful. In those cases the retrograde technique can increase the success rate of the procedure, but the long-term follow-up of such procedures is still unknown. Aim : To assess the efficacy and clinical outcomes during long-term follow-up after retrograde recanalization of the SFA. Material and methods: We included patients after at least one unsuccessful percutaneous antegrade recanalization of the SFA. Patients were evaluated for the procedural and clinical follow-up of mean time 13.9 months. Results: The study included 17 patients (7 females, 10 males who underwent percutaneous retrograde recanalization of the SFA from June 2011 to June 2015. The mean age of patients was 63 ±7 years. Retrograde puncture of the distal SFA was successful in all cases. A retrograde procedure was performed immediately after antegrade failure in 4 (23.5% patients and after a previously failed attempt in 13 (76.5% patients. The procedure was successful in 15 (88.2% patients, and unsuccessful in 2 (11.8% patients. Periprocedural complications included 1 peripheral distal embolization (successfully treated with aspiration thrombectomy, 1 bleeding event from the puncture site and 7 puncture site hematomas. During follow-up the all-cause mortality rate was 5.8% (1 patient, non-cardiac death. The primary patency rate at 12 months was 88.2% and secondary patency 100%. Conclusions : The retrograde SFA puncture seems to be a safe and successful technique for CTO recanalization and is associated with a low rate of perioperative and long-term follow-up complications.

  18. Exercise-based cardiac rehabilitation in twelve European countries results of the European cardiac rehabilitation registry

    DEFF Research Database (Denmark)

    Benzer, Werner; Rauch, Bernhard; Schmid, Jean-Paul

    2017-01-01

    AIM: Results from EuroCaReD study should serve as a benchmark to improve guideline adherence and treatment quality of cardiac rehabilitation (CR) in Europe. METHODS AND RESULTS: Data from 2.054 CR patients in 12 European countries were derived from 69 centres. 76% were male. Indication for CR...

  19. An Algorithm Using Twelve Properties of Antibiotics to Find the Recommended Antibiotics, as in CPGs.

    Science.gov (United States)

    Tsopra, R; Venot, A; Duclos, C

    2014-01-01

    Clinical Decision Support Systems (CDSS) incorporating justifications, updating and adjustable recommendations can considerably improve the quality of healthcare. We propose a new approach to the design of CDSS for empiric antibiotic prescription, based on implementation of the deeper medical reasoning used by experts in the development of clinical practice guidelines (CPGs), to deduce the recommended antibiotics. We investigated two methods ("exclusion" versus "scoring") for reproducing this reasoning based on antibiotic properties. The "exclusion" method reproduced expert reasoning the more accurately, retrieving the full list of recommended antibiotics for almost all clinical situations. This approach has several advantages: (i) it provides convincing explanations for physicians; (ii) updating could easily be incorporated into the CDSS; (iii) it can provide recommendations for clinical situations missing from CPGs.

  20. Building a Strong Vocabulary: A Twelve-Week Plan for Students. 2nd Edition.

    Science.gov (United States)

    Smith, Carl B.

    This second edition presents 12 strategies (focusing on one strategy a week) for students to increase vocabulary and boost communication skills, suggesting that these techniques can easily double the average person's vocabulary. After an introduction, the book presents the following 12 techniques: (1) Expand on What You Know: Synonyms, Antonyms,…

  1. Building a Strong Vocabulary: A Twelve-Week Plan for Students.

    Science.gov (United States)

    Smith, Carl B.

    This book presents 12 strategies (focusing on one strategy a week) for students to increase vocabulary and boost communication skills, suggesting that these techniques can easily double the average person's vocabulary. After an introduction, the book presents the following 12 techniques: (1) "Expand on What You Know: Synonyms, Antonyms, and…

  2. "Her Story Was Complex": A Twine Workshop for Ten- to Twelve-Year-Old Girls

    Science.gov (United States)

    Tran, Kelly M.

    2016-01-01

    In this study, I discuss the need to increase girls' involvement with game design due to the numerous benefits that engaging in this practice might have. In particular, I discuss the tool Twine, an accessible and relatively easy-to-use platform for creating text-based games. I provide an overview of the tool and its potential benefits for…

  3. Twelve-year retrospective review of unintended pregnancies after Essure sterilization in the Netherlands

    NARCIS (Netherlands)

    Hitzerd, Emilie; Schreuder, Henk W R; Vleugels, Michel P H; Veersema, Sebastiaan

    2016-01-01

    Objective To identify factors contributing to the occurrence of unintended pregnancies after Essure sterilization in the Netherlands. Even though Essure is a permanent method of contraception, unintended pregnancies have been reported.  Design  Retrospective case series analysis. Setting Not

  4. Twelve-year retrospective review of unintended pregnancies after Essure sterilization in the Netherlands.

    Science.gov (United States)

    Hitzerd, Emilie; Schreuder, Henk W R; Vleugels, Michel P H; Veersema, Sebastiaan

    2016-04-01

    To identify factors contributing to the occurrence of unintended pregnancies after Essure sterilization in the Netherlands. Even though Essure is a permanent method of contraception, unintended pregnancies have been reported. Retrospective case series analysis. Not applicable. Thirty-five pregnancies were reported in the Netherlands after Essure sterilization from 2002 through 2014 out of 27,346 placements. Data regarding Essure placement procedure, confirmation tests, and pregnancy outcome of the reported cases were obtained and analyzed to identify a possible cause of failure. Four causes of failure were identified: perforation (n = 10), expulsion (n = 7), unilateral placement (n = 7), and luteal pregnancy (n = 2). The occurrence of most pregnancies was related to physician noncompliance (n = 14). The other cases were associated with patient noncompliance (n = 5) or misinterpretation of the confirmation test (n = 9). Most pregnancies occurred within the first 24 months after the 3-month confirmation test (n = 23). The results of this study show that the incidence of pregnancies after Essure sterilization is low. Most pregnancies were related to incorrect positioning of a device or unilateral placement, and seem therefore preventable. Unilateral placement without prior history of salpingectomy should always be considered as unsuccessful sterilization. Furthermore, interpretation of the confirmation tests should be done by trained physicians, and with caution. We want to emphasize the importance of strictly adhering to placement and follow-up protocols. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  5. 2008 USGS Lidar: Twelve County, Illinois (Grundy, Kane, McHenry only)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This LiDAR data is within Illinois Department of Transportation districts 1 and 3 covering Grundy, Kane and McHenry counties. The data is updated from its original...

  6. DOME-SHAPED MACULA IN MYOPIC EYES: Twelve-Month Follow-up.

    Science.gov (United States)

    Lorenzo, Daniel; Arias, Luis; Choudhry, Netan; Millan, Eduard; Flores, Ignacio; Rubio, Marcos J; Cobos, Estefanía; García-Bru, Pere; Filloy, Alejandro; Caminal, Josep M

    2017-04-01

    To study the long-term clinical course of dome-shaped macula in myopic eyes and to evaluate treatment efficacy for subretinal fluid (SRF) as a related complication. A retrospective, single-center consecutive case series study was conducted. The authors analyzed myopic eyes with dome-shaped macula in patients who presented for evaluation of decreased vision. Dome-shaped macula was defined as a convexity of the retina-choroidal macular complex seen on spectral domain optical coherence tomography images. All patients were followed for at least 12 months (mean, 25 months). Fluorescein angiography and/or indocyanine green angiography were performed in cases with SRF to rule out choroidal neovascularization. A total of 56 dome-shaped macula eyes from 36 patients were included in the study (bilateral in 55% of patients). Mean patient age was 56.9 ± 13.1 years. The mean spherical equivalent was -9.1 ± 6.0 diopters; 53% of eyes were considered highly myopic (>-6 diopters) and 47% of eyes were mildly myopic. In most cases (37 eyes; 66.1%), the dome-shaped macula was detected on vertical spectral domain optical coherence tomography scan patterns. No significant changes (P ≥ 0.1) were observed in mean best-corrected visual acuity or mean central foveal thickness from baseline to final follow-up. Subretinal fluid was present in 29 eyes (51.8%) at baseline, with no differences in best-corrected visual acuity in eyes with and without SRF (P ≥ 0.05). Nineteen of the 29 SRF eyes were treated: 8 underwent low-fluence photodynamic therapy, whereas 7 received bevacizumab, and 4 ranibizumab. No significant differences were found between treated and untreated SRF eyes in best-corrected visual acuity improvement (P ≥ 0.1), or complete resolution of SRF (P ≥ 0.1). Likewise, photodynamic therapy did not yield any significant benefit versus untreated eyes in best-corrected visual acuity or improvement of SRF. Dome-shaped macula is a condition associated with myopic eyes that seems to remain stable over time in terms of vision and macular profiles. It is often associated with chronic SRF, for which no effective treatment is current available. However, SRF does not seem to be a significant cause of visual impairment.

  7. Should title lengths really adhere to the American Psychological Association's twelve word limit?

    Science.gov (United States)

    Hallock, Robert M; Dillner, Kari M

    2016-04-01

    The publication manual for the American Psychological Association (APA) suggests that title lengths do not exceed 12 words, yet journals do not prevent longer titles. Here, we examined title lengths in APA journals to see how many exceeded the APA's suggested limit. First, we conducted a systematic analysis of 235 articles in the current issues of 23 APA journals. A total of 52% of titles were more than 12 words long. Second, we examined articles from APA journals that were at least 50 years old to examine whether title lengths have changed over time. Our results suggested that the average title lengths have indeed increased with time. One of 2 courses should be taken. Perhaps science is becoming more complex that longer titles are needed in order to convey the primary message to the reader. If this is the case, then the APA's word limit should be increased. On the other hand, however, maybe editor and reviewers should try to enforce the current word limit to force writers to be succinct. Either way, editors should make their preferences clear so that the trend for longer titles does not continue unchecked. (c) 2016 APA, all rights reserved).

  8. NASA/JPL Solar System Educators Program: Twelve Years of Success and Looking Forward

    Science.gov (United States)

    Ferrari, K.; NASA/JPL Solar System Educators Program

    2011-12-01

    Since 1999, the NASA/JPL Solar System Educators Program (SSEP) has been the model of a successful master teacher volunteer program. Integrating nationwide volunteers in this professional development program helped optimize agency funding set aside for education. Through the efforts of these volunteers, teachers across the country became familiarized with NASA's STEM (Science, Technology, Engineering and Mathematics) educational materials, schools added these products to their curriculum and students benefitted. The years since 1999 have brought about many changes. There have been advancements in technology that allow more opportunities for telecon and web based learning methods. Along with those advancements have also come significant challenges. With NASA budgets for education shrinking, this already frugal program has become more spartan. Teachers face their own hardships with school budget cuts, limited classroom time and little support for professional development. In order for SSEP to remain viable in the face of these challenges, the program management, mission funders and volunteers themselves are working together to find ways of maintaining the quality that made the program a success and at the same time incorporate new, cost-effective methods of delivery. The group will also seek new partnerships to provide enhancements that will aid educators in advancing their careers at the same time as they receive professional development. By working together and utilizing the talent and experience of these master teachers, the Solar System Educators Program can enjoy a revitalization that will meet the needs of today's educators at the same time as renewing the enthusiasm of the volunteers.

  9. Community Energy Systems and the Law of Public Utilities. Volume Twelve. Georgia

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L

    1981-01-01

    A detailed description of the laws and programs of the State of Georgia governing the regulation of public energy utilities, the siting of energy generating and transmission facilities, the municipal franchising of public energy utilities, and the prescription of rates to be charged by utilities including attendant problems of cost allocations, rate base and operating expense determinations, and rate of return allowances. These laws and programs are analyzed to identify impediments which they may present to the implementation of Integrated Community Energy Systems (ICES). This report is one of fifty-one separate volumes which describe such regulatory programs at the Federal level and in each state as background to the report entitled Community Energy Systems and the Law of Public Utilities - Volume One: An Overview. This report also contains a summary of a strategy described in Volume One - An Overview for overcoming these impediments by working within the existing regulatory framework and by making changes in the regulatory programs to enhance the likelihood of ICES implementation.

  10. Intoxication by mining revenues. San Marcos district politics after twelve years of Antamina’s presence

    Directory of Open Access Journals (Sweden)

    Guillermo Salas Carreño

    2010-12-01

    Full Text Available This paper describes and analyses the changes in local politicstaken place in the district of San Marcos (Huari, Ancash associatedwith the arrival of the Canon Minero – a fraction of taxes paid byAntamina mining company to the Peruvian State. Canon Minero hasincreased sudden and spectacularly the municipality’s funds so muchthat currently San Marcos in «ones of the Peruvian richest districts».The paper pays attention to the municipal elections of 2006 and theimplementation of the Plan Piloto de Mantenimiento de la InfraestructuraPública, a program of temporary work for all San Marcos’citizens. The latter was key for launching a novel alliance betweenthe municipality and the rural population, particularly with the ConoSur composed by hamlets which were traditionally unimportantactors in district politics. Hence, district politics had stopped to bedominated by the struggle between two factions of former landlordfamilies and had become articulated by the opposition between therural hamlets and the town of San Marcos with the emergence ofethnic political claims. Also, local politics ceased to revolve aroundAntamina and has become entangled with struggles over the administrationof Canon Minero. Rural communities which have directnegotiations with Antamina remain important political actors whichare independent from the municipality and are even oppose to it.

  11. Intoxication by mining revenues. San Marcos district politics after twelve years of Antamina’s presence

    OpenAIRE

    Salas Carreño, Guillermo

    2012-01-01

    This paper describes and analyses the changes in local politicstaken place in the district of San Marcos (Huari, Ancash) associatedwith the arrival of the Canon Minero – a fraction of taxes paid byAntamina mining company to the Peruvian State. Canon Minero hasincreased sudden and spectacularly the municipality’s funds so muchthat currently San Marcos in «ones of the Peruvian richest districts».The paper pays attention to the municipal elections of 2006 and theimplementation of the Plan Piloto...

  12. Twelve-year analysis of microbial keratitis trends at a UK tertiary hospital.

    Science.gov (United States)

    Tan, S Z; Walkden, A; Au, L; Fullwood, C; Hamilton, A; Qamruddin, A; Armstrong, M; Brahma, A K; Carley, F

    2017-08-01

    PurposeTo investigate the frequencies, trends, and in vitro drug susceptibilities of the causative pathogens in microbial keratitis in Manchester Royal Eye Hospital.Patients and methodsCorneal scrape results recorded by the microbiology service between 2004 and 2015 were extracted from an established database. A total of 4229 corneal scrape specimens were identified from an established database. First-line antibiotic treatment in our centre during the study period was ofloxacin and second line was cefuroxime and gentamicin.ResultsMean age was 45.9±21.0. A total of 1379 samples (32.6%) were culture positive. One hundred forty-eight (10.7%) specimens cultured multiple organisms. Of the 1539 organisms identified, 63.3% were Gram-positive bacteria, 27.3% Gram-negative bacteria, 7.1% fungi, and 2.3% Acanthamoebae. A decreasing trend in Gram-positive isolates was found together with a stable trend in Gram negatives and an increasing trend in Acanthamoeba and fungi. There appeared to be a significant increasing trend of Moraxella infection (P=0.001). In all, 83.1 and 90.8% of Gram-positive and -negative isolates tested were susceptible to ofloxacin, respectively. Cefuroxime covered 86.6% of Gram-positive and 61.4% of Gram-negative isolates, whereas gentamicin covered 88.8 and 96.5% of Gram-positive and -negative isolates, respectively.ConclusionWe found a change in the type of Gram-negative organisms isolated over time, with the Moraxella species on the rise. Reassuringly, no significant increase in resistance was observed in vitro for any of the commonly used antibiotics. Ofloxacin remains a good first-line antibiotic treatment but duo-therapy does have broader coverage and should be considered in non-responsive cases.

  13. Screening of crude extracts of twelve medicinal plants and “wonder ...

    African Journals Online (AJOL)

    The phytochemical analysis of the plant extract and the Epa-Ijebu showed the presence of bioactive compounds: tannin, flavonoid, alkaloids, phylobatanin, anthocyanin, reducing sugar, saponin and anthraquinone. Our results offer a scientific basis for the traditional use of aqueous and ethanolic extracts of A. ascalonicum, ...

  14. Twelve factors critical to the success of WDM at the policy and at the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    and monetary units. A WDM agency has to be able to show results (such as water savings measured in cubic meters for example) in order to compete for attention with older and better established supply-side agencies. Such data may be hard to find, or estimate, but it can be very persuasive in furthering the WDM agenda.

  15. A controlled trial of Partners in Dementia Care: veteran outcomes after six and twelve months.

    Science.gov (United States)

    Bass, David M; Judge, Katherine S; Snow, A Lynn; Wilson, Nancy L; Morgan, Robert O; Maslow, Katie; Randazzo, Ronda; Moye, Jennifer A; Odenheimer, Germaine L; Archambault, Elizabeth; Elbein, Richard; Pirraglia, Paul; Teasdale, Thomas A; McCarthy, Catherine A; Looman, Wendy J; Kunik, Mark E

    2014-01-01

    "Partners in Dementia Care" (PDC) tested the effectiveness of a care-coordination program integrating healthcare and community services and supporting veterans with dementia and their caregivers. Delivered via partnerships between Veterans Affairs medical centers and Alzheimer's Association chapters, PDC targeted both patients and caregivers, distinguishing it from many non-pharmacological interventions. Hypotheses posited PDC would improve five veteran self-reported outcomes: 1) unmet need, 2) embarrassment about memory problems, 3) isolation, 4) relationship strain and 5) depression. Greater impact was expected for more impaired veterans. A unique feature was self-reported research data collected from veterans with dementia. Five matched communities were study sites. Two randomly selected sites received PDC for 12 months; comparison sites received usual care. Three structured telephone interviews were completed every 6 months with veterans who could participate. Of 508 consenting veterans, 333 (65.6%) completed baseline interviews. Among those who completed baseline interviews, 263 (79.0%) completed 6-month follow-ups and 194 (58.3%) completed 12-month follow-ups. Regression analyses showed PDC veterans had significantly less adverse outcomes than those receiving usual care, particularly for more impaired veterans after 6 months, including reduced relationship strain (B = -0.09; p = 0.05), depression (B = -0.10; p = 0.03), and unmet need (B = -0.28; p = 0.02; and B = -0.52; p = 0.08). PDC veterans also had less embarrassment about memory problems (B = -0.24; p = 0.08). At 12 months, more impaired veterans had further reductions in unmet need (B = -0.96; p needs and improve the psychosocial functioning of persons with dementia. NCT00291161.

  16. Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature.

    Science.gov (United States)

    Dar-Odeh, Najla S; Hayajneh, Wail A; Abu-Hammad, Osama A; Hammad, Huda M; Al-Wahadneh, Adel M; Bulos, Najwa K; Mahafzah, Azmi M; Shomaf, Maha S; El-Maaytah, Mohammed A; Bakri, Faris G

    2010-02-17

    Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients. The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic non-specific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient. Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage.

  17. Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature

    Directory of Open Access Journals (Sweden)

    Shomaf Maha S

    2010-02-01

    Full Text Available Abstract Background Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients. Findings The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic non-specific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient. Conclusion Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage.

  18. Twelve years of follow up of cases with old 241Am internal contamination.

    Science.gov (United States)

    Malátová, Irena; Vrba, Tomás; Becková, Vera; Pospísilová, Helena

    2010-10-01

    A group of workers internally contaminated with Am have been followed for about 12 years. The source of contamination was AmO2 powder used for production of AmBe neutron sources and other applications. The production of some radionuclide sources included chemical treatment of the original material, which transformed the americium into the nitrate, but mostly powder metallurgy was used for production of sources for smoke detectors. In vivo measurement of the workers was performed with two LEGe detectors placed near the head of the measured person. Calibration was performed with four different physical skull phantoms of different origin and a voxel phantom with Monte Carlo simulation, which was developed to fit the head sizes of individual persons. Samples of urine and feces were analyzed by means of radiochemical separation followed by alpha-spectrometry. Separation of 241Am from mineralized excreta was performed by combined anion exchange and extraction chromatographic techniques. As a tracer, 243Am was used. When the measured data (83 data on skeletal activity, activity in 389 bioassay samples) were compared with International Commission on Radiological Protection's and Leggett's biokinetic models of americium, it was found that in most cases, after more than 15 y since the intake, the excretion rate was lower (or skeletal activity higher) than predicted. On the other hand, the ratio of excreted activity in urine and feces agrees well with model predictions.

  19. Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir

    LENUS (Irish Health Repository)

    Cotter, Aoife G

    2013-05-16

    AbstractObjectiveTo determine the factors associated with change in bilirubin concentration 12 weeks after the initiation of an atazanavir (ATV)-containing antiretroviral regimen.MethodsWe performed a retrospective case note review of all patients prescribed ATV between January 2004 and October 2007 in a cohort of HIV infected subjects. Data collected included baseline demographics, hepatitis B and C serology, current antiretroviral therapy, baseline and week 12 routine bloods. The primary endpoint was the change in bilirubin concentration at 12 weeks after start of ATV. Multvariable linear regression was performed to assess the relationships between the change in bilirubin and variables of interest. Results: Eighty-three ATV-treated patients were included in the analysis of whom 46 (60.5%) were hepatitis C antibody positive. The median (interquartile range) change in bilirubin by week 12 was 16 (4, 22) umol\\/L; only 1 patient developed grade 4 hyperbilirubinaemia at week 12. After controlling for baseline bilirubin levels, HCV seropositivity and baseline ALP were associated with a smaller change in bilirubin over the 12 weeks with a trend towards lower increases in those receiving tenofovir. Sensitivity analyses reported similar associations with methadone use and injection drug use, when these variables replaced HCV sero-positivity in the model. Conclusion: Patients with hepatitis C co-infection experience smaller changes in bilirubin upon exposure to ATV. Although the underlying mechanism for this association remains unclear, these data support the safe use of this drug in this patient setting. Further research into the clinical predictors of ATV-related hyperbilirubinaemia is warranted.

  20. Natural autoantibodies in Bos taurus calves during the first twelve weeks of life

    NARCIS (Netherlands)

    Mayasari, N.; Knegsel, van A.T.M.; Vries Reilingh, de G.; Kemp, B.; Parmentier, H.K.

    2016-01-01

    Natural autoantibodies (NAAb) have a role in maintaining physiological homeostasis and prevention of infections, and have been found in mammalian species tested so far. Albeit NAAb levels rise with age, little is known about the origin, function, regulation and initiation of NAAb in young

  1. Synthesis of most polyene natural product motifs using just twelve building blocks and one coupling reaction

    Science.gov (United States)

    Woerly, Eric M.; Roy, Jahnabi; Burke, Martin D.

    2014-01-01

    The inherent modularity of polypeptides, oligonucleotides, and oligosaccharides has been harnessed to achieve generalized building block-based synthesis platforms. Importantly, like these other targets, most small molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic building block-based construction. Supporting this hypothesis, here we report that the polyene motifs found in >75% of all known polyene natural products can be synthesized using just 12 building blocks and one coupling reaction. Using the same general retrosynthetic algorithm and reaction conditions, this platform enabled the synthesis of a wide range of polyene frameworks covering all of this natural product chemical space, and first total syntheses of the polyene natural products asnipyrone B, physarigin A, and neurosporaxanthin β-D-glucopyranoside. Collectively, these results suggest the potential for a more generalized approach for making small molecules in the laboratory. PMID:24848233

  2. Language Development of Three- to Twelve-Year-Old Twins Compared to Singletons.

    Science.gov (United States)

    Dʼhaeseleer, Evelien; Geenens, Eline; Parmentier, Sarah; Corthals, Paul; Van Lierde, Kristiane

    2016-01-01

    The language development of twins tends to lag behind in comparison to that of singletons. The purpose of this study was to compare expressive and receptive language skills of 3- to 12-year-old twins with singletons. Secondly, correlations between language differences between twins and singletons and age were investigated. Twenty-four twins with a mean age of 5.1 years participated in the study. The control group consisted of 24 singletons who were matched for gender and age. Language development was investigated using the Clinical Evaluation of Language Fundamentals. Twins scored significantly lower for expressive and receptive language skills compared to singletons. Even when excluding preterm-born children, twins still scored significantly lower for expressive language skills. There was no correlation between age and language differences between twins and their matched singletons. Twins score lower for expressive and receptive language skills compared to singletons, and preterm birth cannot be regarded as the main cause for the language delay. The language delay in twins is rather mild but does not seem to decrease with increasing age. © 2016 S. Karger AG, Basel.

  3. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

    NARCIS (Netherlands)

    Davie, J.J.; Earl, J.; Vries, S.P. de; Ahmed, A.; Hu, F.Z.; Bootsma, H.J.; Stol, K.; Hermans, P.W.M.; Wadowsky, R.M.; Ehrlich, G.D.; Hays, J.P.; Campagnari, A.A.

    2011-01-01

    BACKGROUND: M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding $33 billion in

  4. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates

    NARCIS (Netherlands)

    J.J. Davie (Jeremiah ); J. Earl (Josh); S.P.W. de Vries (Stefan); A. Ahmed (Azad); F.Z. Hu (Fen); H.J. Bootsma (Hester); K. Stol (Kim); P.W.M. Hermans (Peter); R.M. Wadowsky (Robert M.); G.D. Ehrlich (Garth); J.P. Hays (John); A.A. Campagnari (Anthony)

    2011-01-01

    textabstractBackground: M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding

  5. Twelve tips for getting started using mixed methods in medical education research.

    Science.gov (United States)

    Lavelle, Ellen; Vuk, Jasna; Barber, Carolyn

    2013-04-01

    Mixed methods research, which is gaining popularity in medical education, provides a new and comprehensive approach for addressing teaching, learning, and evaluation issues in the field. The aim of this article is to provide medical education researchers with 12 tips, based on consideration of current literature in the health professions and in educational research, for conducting and disseminating mixed methods research. Engaging in mixed methods research requires consideration of several major components: the mixed methods paradigm, types of problems, mixed method designs, collaboration, and developing or extending theory. Mixed methods is an ideal tool for addressing a full range of problems in medical education to include development of theory and improving practice.

  6. Vital Signs Predict Rapid-Response Team Activation within Twelve Hours of Emergency Department Admission

    Directory of Open Access Journals (Sweden)

    James M. Walston

    2016-05-01

    Full Text Available Introduction: Rapid-response teams (RRTs are interdisciplinary groups created to rapidly assess and treat patients with unexpected clinical deterioration marked by decline in vital signs. Traditionally emergency department (ED disposition is partially based on the patients’ vital signs (VS at the time of hospital admission. We aimed to identify which patients will have RRT activation within 12 hours of admission based on their ED VS, and if their outcomes differed. Methods: We conducted a case-control study of patients presenting from January 2009 to December 2012 to a tertiary ED who subsequently had RRT activations within 12 hours of admission (early RRT activations. The medical records of patients 18 years and older admitted to a non-intensive care unit (ICU setting were reviewed to obtain VS at the time of ED arrival and departure, age, gender and diagnoses. Controls were matched 1:1 on age, gender, and diagnosis. We evaluated VS using cut points (lowest 10%, middle 80% and highest 10% based on the distribution of VS for all patients. Our study adheres to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology guidelines for reporting observational studies. Results: A total of 948 patients were included (474 cases and 474 controls. Patients who had RRT activations were more likely to be tachycardic (odds ratio [OR] 2.02, 95% CI [1.25-3.27], tachypneic (OR 2.92, 95% CI [1.73-4.92], and had lower oxygen saturations (OR 2.25, 95% CI [1.42-3.56] upon arrival to the ED. Patients who had RRT activations were more likely to be tachycardic at the time of disposition from the ED (OR 2.76, 95% CI [1.65-4.60], more likely to have extremes of systolic blood pressure (BP (OR 1.72, 95% CI [1.08-2.72] for low BP and OR 1.82, 95% CI [1.19-2.80] for high BP, higher respiratory rate (OR 4.15, 95% CI [2.44-7.07] and lower oxygen saturation (OR 2.29, 95% CI [1.43-3.67]. Early RRT activation was associated with increased healthcare utilization and worse outcomes including increased rates of ICU admission within 72 hours (OR 38.49, 95%CI [19.03-77.87], invasive interventions (OR 5.49, 95%CI [3.82-7.89], mortality at 72 hours (OR 4.24, 95%CI [1.60-11.24], and mortality at one month (OR 4.02, 95%CI [2.44-6.62]. Conclusion: After matching for age, gender and ED diagnosis, we found that patients with an abnormal heart rate, respiratory rate or oxygen saturation at the time of ED arrival or departure are more likely to trigger RRT activation within 12 hours of admission. Early RRT activation was associated with higher mortality at 72 hours and one month, increased rates of invasive intervention and ICU admission. Determining risk factors of early RRT activation is of clinical, operational, and financial importance, as improved medical decision-making regarding disposition would maximize allocation of resources while potentially limiting morbidity and mortality.

  7. Vital Signs Predict Rapid-Response Team Activation Within Twelve Hours of Emergency Department Admission.

    Science.gov (United States)

    Walston, James M; Cabrera, Daniel; Bellew, Shawna D; Olive, Marc N; Lohse, Christine M; Bellolio, M Fernanda

    2016-05-01

    Rapid-response teams (RRTs) are interdisciplinary groups created to rapidly assess and treat patients with unexpected clinical deterioration marked by decline in vital signs. Traditionally emergency department (ED) disposition is partially based on the patients' vital signs (VS) at the time of hospital admission. We aimed to identify which patients will have RRT activation within 12 hours of admission based on their ED VS, and if their outcomes differed. We conducted a case-control study of patients presenting from January 2009 to December 2012 to a tertiary ED who subsequently had RRT activations within 12 hours of admission (early RRT activations). The medical records of patients 18 years and older admitted to a non-intensive care unit (ICU) setting were reviewed to obtain VS at the time of ED arrival and departure, age, gender and diagnoses. Controls were matched 1:1 on age, gender, and diagnosis. We evaluated VS using cut points (lowest 10%, middle 80% and highest 10%) based on the distribution of VS for all patients. Our study adheres to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for reporting observational studies. A total of 948 patients were included (474 cases and 474 controls). Patients who had RRT activations were more likely to be tachycardic (odds ratio [OR] 2.02, 95% CI [1.25-3.27]), tachypneic (OR 2.92, 95% CI [1.73-4.92]), and had lower oxygen saturations (OR 2.25, 95% CI [1.42-3.56]) upon arrival to the ED. Patients who had RRT activations were more likely to be tachycardic at the time of disposition from the ED (OR 2.76, 95% CI [1.65-4.60]), more likely to have extremes of systolic blood pressure (BP) (OR 1.72, 95% CI [1.08-2.72] for low BP and OR 1.82, 95% CI [1.19-2.80] for high BP), higher respiratory rate (OR 4.15, 95% CI [2.44-7.07]) and lower oxygen saturation (OR 2.29, 95% CI [1.43-3.67]). Early RRT activation was associated with increased healthcare utilization and worse outcomes including increased rates of ICU admission within 72 hours (OR 38.49, 95%CI [19.03-77.87]), invasive interventions (OR 5.49, 95%CI [3.82-7.89]), mortality at 72 hours (OR 4.24, 95%CI [1.60-11.24]), and mortality at one month (OR 4.02, 95%CI [2.44-6.62]). After matching for age, gender and ED diagnosis, we found that patients with an abnormal heart rate, respiratory rate or oxygen saturation at the time of ED arrival or departure are more likely to trigger RRT activation within 12 hours of admission. Early RRT activation was associated with higher mortality at 72 hours and one month, increased rates of invasive intervention and ICU admission. Determining risk factors of early RRT activation is of clinical, operational, and financial importance, as improved medical decision-making regarding disposition would maximize allocation of resources while potentially limiting morbidity and mortality.

  8. Growth, Flowering Time and Quality of Twelve Apple Varieties under Urmia Climate

    Directory of Open Access Journals (Sweden)

    Reza Rezaee

    2017-08-01

    Full Text Available Introduction: Apple is a major commercial fruit crop grown in Iran. The country produces approximately 1.6 - 2.7 million tonnes of apples and was one of the top 10 apple producing countries in the world during the last decade. West Azerbaijan province, with more than 50,000 hectare of apple orchards and by producing of approximately one million tonne of fresh apple, is one of the main regions of apple production in Iran. In this region, two common apple cultivars Red Delicious and Golden Delicious are dominant (>90%, which needs to be updated by new apple cultivars to satisfy different technical/management as well as worldwide marketing requirements. Apple cultivars evaluations was started in Iran since 1953 and a lot of apple collection were established, but and until new apple cultivar was not introduced to farmers, As a first step for introduction of alternative cultivars, in this study, vegetative growth, flowering time, fruit ripening time as well as fruit quality of 12 apple (Malus pumilla Mill cultivars were evaluated under Urmia climatic conditions. Therefore, the main objective of this study was to evaluate vegetative growth, quality and compatibility of some apple cultivars to allow selection of alternative cultivars for commercial apple production in the northwest province of Iran. Materials and methods: This experiment was conducted at the Kahriz Horticultural Research Station located in Urmia-Iran (latitude 44°07' E; 37º 53' N.; altitude, 1325 m above sea level. The experimental design was randomized complete blocks, with 12 treatments (cultivars and three replications. The apple cultivars including Golden Delicious, Red Delicious, Red Spur, Fuji, Delbar Stival, Golden Smothee, Jonagold, Gholab-Kohanz, Golab-Kermanshah, Mahali Shikhi and Shafie Abadi were grafted on MM 111 rootstock. Trees were 10-year-old with a planting distance of 3 x 4 m and were trained as modified leader system. Data collected for annual shoot growth, time of blooming as well as fruit quality traits for one growth season and all data obtained from the trial were analysed using combined ANOVA and means were compared using the Duncan's Multiple Range Test (DMRT. SPSS (version 20 was used to analyse the data. Results and Discussion: Analysis of variance showed that apple cultivars were significantly different for all traits. Based on the means comparison test, the most and least annual shoot growth was observed in Red Delicious and Red Spur with 51.80 and 26.23 cm, respectively. The studied apple cultivars were ranked in three and five groups in terms of flowering and fruit ripening time, respectively. Flowering time is important for breeding as well as pollination purposes and in this regard there were significant differences among cultivars. The highest and the lowest fruit weight 236.07 and 63.28 g was obtained from Red Delicious and Mahale Sheikhi, respectively. The highest fruit firmness was observed in Fuji (9.17, followed by Golab Kermanshah (9.13, Red Delicious (9.03 and Golden Delicious (8.76. The highest (18.6% TSS was observed in Fuji cultivar followed by Red Delicious (17.00%, and the lowest TSS was observed in all of early ripening cultivars. Titratable acidity (TA was also significantly different among cultivars with Fuji showing the highest (1.32 and Golab Kermanshah, Golab Kohanz and Golshahi were the lowest (0.31-0.44 values. Compared to the other cultivars, Red Spur and Jonagold with a more L/D ratio (0.91 showed an elongated fruit form. Fruit shape especially the ratio of L/D has an important role in marketing. In addition, due to low growth and dense canopy as well as good fruit quality, the two recent cultivars are recommended for high density planting. Conclusion: Final ranking of cultivars based on cumulative ranks from different traits showed that the higher ranks for Fuji, Red Spur and Goden Smothee, indicating their higher potential as an alternative to the Red and Golden delicious. Among the evaluated cultivars, three cultivars including Jonagold, Golshahi and Delbar Stivel were the best option to fulfill market demands for fresh fruit during mid-summer trough early autumn. It should be emphasized that these cultivars may be suitable for similar climates, but because of the effects of growing conditions (i.e. soil type, climate, cultural practices etc. on the results of cultivar evaluation projects, complementary trials should be done in other regions before commercial planting commences. Continuous evaluation of new apple cultivars is an important prerequisite for sustainable apple industry.

  9. After twelve years of exploration Cluff Lake uranium within Amok's grasp

    International Nuclear Information System (INIS)

    Watson, L.M.

    1979-01-01

    Amok Ltd. recently began construction of a uranium mine and processing plant at Cluff Lake, Saskatchewan. The deposits occur in the Carswell Dome, a formation of basement rock intruding through the Athabaska sandstone which appears to have been caused by a meteorite impact approximately 467 million years ago. The uranium deposits are around 1 billion years old and are linked to organic compounds. Proven reserves are in the order of 23 000 million tonnes, averaging 7 percent U 3 O 8 but ranging from 0.3 to 45 percent. The D ore body, the richest, will be mined first in an open pit operation that will start up at 317 tpd in Sept. 1980. Special radiation protection precautions are necessary. Great care will be taken with mine wastes, waste water, and ore stockpiles to avoid groundwater contamination. High-grade ore can proceed directly to chemical treatment after crushing, while low-grade ore will receive gravity concentration. Sulphuric acid will be used to dissolve the uranium, followed by filtration, lime treatment to remove iron and aluminum, and neutralization with magnesium oxide to precipitate yellowcake. Radioactive wastes will be stored underground in concrete vaults; non-radioactive tailings will go to an impervious pond. (LL)

  10. Simultaneous determination of twelve trace elements in estuarine and sea water using pre-irradiation chromatography

    International Nuclear Information System (INIS)

    Greenberg, R.R.; Kingston, H.M.

    1982-01-01

    A procedure is described for the preconcentration of 100 m of estuarine and seawater into a solid sample using Chelex-100 resin. This solid sample weighs less than half a gram and contains the transition metals and many other elements of interest, but is essentially free from the alkali metals, the alkaline earth metals, and the halogens. The concentrations of Co, Cr, Cu, Fe, Mn, Mo, Ni, Sc, Th, U, V and Zn have been determined in seawater when this procedure was coupled to neutron activation analysis. (author)

  11. A Cross-Sectional Survey of HIV Testing and Prevalence in Twelve Brazilian Correctional Facilities.

    Directory of Open Access Journals (Sweden)

    Renata Viebrantz Enne Sgarbi

    Full Text Available Prior studies have reported higher HIV prevalence among prisoners than the general population in Brazil, but data have been derived from single prisons. The aim of this study was to evaluate HIV testing practices, prevalence and linkage to care among inmates in a network of 12 prisons.We administered a questionnaire to a population-based sample of inmates from 12 prisons in Central-West Brazil and collected sera for HIV and syphilis testing from January to December 2013. We evaluated factors associated with HIV testing and infection using multivariable logistic regression models. Six months after HIV testing, we assessed whether each HIV-infected prisoner was engaged in clinical care and whether they had started antiretroviral therapy.We recruited 3,362 inmates, of whom 2,843 (85% were men from 8 prisons, and 519 (15% were women from 4 prisons. Forty-five percent of participants reported never having been tested for HIV previously. In multivariable analysis, the variables associated with previous HIV testing were lack of a stable partner (adjusted odds ratio [AOR]: 1.38; 95% CI: 1.18-1.60, completed more than four years of schooling (AOR 1.40; 95% CI: 1.20-1.64, history of previous incarceration (AOR: 1.68; 95% CI: 1.43-1.98, history of mental illness (AOR 1.52; 95% CI: 1.31-1.78 and previous surgery (AOR 1.31; 95% CI: 1.12-1.52. Fifty-four (1.6% of all participants tested positive for HIV; this included 44 (1.54% men and 10 (1.92% women. Among male inmates, HIV infection was associated with homosexuality (AOR 6.20, 95% CI: 1.73-22.22, self-report of mental illness (AOR 2.18, 95% CI: 1.13-4.18, history of sexually transmitted infections (AOR 3.28, 95% CI: 1.64-6.56, and syphilis sero-positivity (AOR 2.54, 95% CI: 1.20-5.39. Among HIV-infected individuals, 34 (63% were unaware of their HIV status; only 23 of these 34 (68% newly diagnosed participants could be reached at six month follow-up, and 21 of 23 (91% were engaged in HIV care.HIV testing rates among prison inmates are low, and the majority of HIV-infected inmates were unaware of their HIV diagnosis. Incarceration can be an opportunity for diagnosis and treatment of HIV among vulnerable populations who have poor access to health services, but further work is needed on transitional HIV care for released inmates.

  12. Twelve-month space changes after premature loss of a primary maxillary first molar.

    Science.gov (United States)

    Lin, Yai-Tin; Lin, Wen-Hsien; Lin, Yng-Tzer J

    2011-05-01

    Many early investigations concerning space changes following premature extraction of primary molars had a cross-sectional design, a small sample size, and a somewhat crude methodology, which may have led to misunderstandings. The aim of this study was to use established longitudinal data to investigate ongoing (12-month) dental-arch space problems arising as a result of premature loss of a primary maxillary first molar. Thirteen children (mean ± SD age at time of tooth extraction, 6.0 ± 0.74 years) with unilateral premature loss of a primary maxillary first molar were selected for this study. Maxillary dental study casts were obtained from participants 2 or 3 days after the tooth was removed, as well as at a follow-up appointment 12 months later. Six reference lines were measured on the study cast: D + E space, arch width, arch length, intercanine width, intercanine length, and arch perimeter. For each participant, the D + E space of the contralateral intact primary molar served as a control. A paired t-test was used to compare the cast measurements between initial examination and 12-month follow-up. A t-test was used to compare D + E space changes with those of the control group. The D + E space of the extraction side after 12 months was significantly smaller than that of the control side (P 0.05). The 12-month space changes in the maxillary dental arch after premature loss of a primary maxillary first molar consist mainly of distal drift of the primary canine toward the extraction site. Mesial movement of permanent molars or tilting of the primary molars did not occur. An increased arch dimension was found especially in the anterior segment (intercanine width and length). There is no need for the use of space maintainers from the results in this study in cases of premature loss of a primary first molar. © 2010 The Authors. International Journal of Paediatric Dentistry © 2010 BSPD, IAPD and Blackwell Publishing Ltd.

  13. Twelve Monkeys, the Kassandra dilemma and innovation diffusion: transdisciplinary lessons for animal and environmental activism

    OpenAIRE

    Sarah Rutherford Smith

    2014-01-01

    Animal activists and environmental activists believe that the world and its inhabitants face devastating consequences in the future if behaviour towards and the treatment of animals and the environment do not change. However, despite their predictions many people are not swayed to change their behaviour. This article suggests that these activists experience what is known as Kassandra’s dilemma; the conundrum of knowing what the future holds but being unable to prevent events fr...

  14. Knocked by the shuttlecock: twelve sight-threatening blunt-eye injuries in Australian badminton players.

    Science.gov (United States)

    Jao, Kathy K; Atik, Alp; Jamieson, Michael P; Sheales, Mariana P; Lee, Matthew H; Porter, Ashley; Roufas, Athena; Goldberg, Ivan; Zamir, Ehud; White, Andrew; Skalicky, Simon E

    2017-07-01

    Non-penetrating ocular injuries from badminton shuttlecocks can result in severe damage and life-long complications. This case series highlights the morbidity of such injuries, particularly in regard to post-traumatic glaucoma. This is a retrospective case series of 12 patients with shuttlecock-related blunt eye injuries sustained during badminton play without eye protection. By approaching colleagues through conference presentations and networking, the authors have attempted to gather all known cases of shuttlecock ocular injury managed in tertiary ocular emergency departments or private ophthalmological clinics in Victoria and New South Wales, Australia in 2015. This is the first multicentre case series to describe badminton-related ocular injuries in Australia. Our case series demonstrates, in particular, long-term glaucoma-related morbidity for patients over a large age range (16 to 77 years), with one patient requiring ongoing management 26 years following their initial injury. The cases reported further add to the literature promoting awareness of badminton-related ocular injury. We encourage player education and advocacy on badminton-related eye injuries and appropriate use of eye protection to reduce associated morbidity. © 2016 Optometry Australia.

  15. EO-1/Hyperion: Nearing Twelve Years of Successful Mission Science Operation and Future Plans

    Science.gov (United States)

    Middleton, Elizabeth M.; Campbell, Petya K.; Huemmrich, K. Fred; Zhang, Qingyuan; Landis, David R.; Ungar, Stephen G.; Ong, Lawrence; Pollack, Nathan H.; Cheng, Yen-Ben

    2012-01-01

    The Earth Observing One (EO-1) satellite is a technology demonstration mission that was launched in November 2000, and by July 2012 will have successfully completed almost 12 years of high spatial resolution (30 m) imaging operations from a low Earth orbit. EO-1 has two unique instruments, the Hyperion and the Advanced Land Imager (ALI). Both instruments have served as prototypes for NASA's newer satellite missions, including the forthcoming (in early 2013) Landsat-8 and the future Hyperspectral Infrared Imager (HyspIRI). As well, EO-1 is a heritage platform for the upcoming German satellite, EnMAP (2015). Here, we provide an overview of the mission, and highlight the capabilities of the Hyperion for support of science investigations, and present prototype products developed with Hyperion imagery for the HyspIRI and other space-borne spectrometers.

  16. Relation between macular morphology and treatment frequency during twelve months with ranibizumab for diabetic macular edema.

    Directory of Open Access Journals (Sweden)

    Yuki Mori

    Full Text Available To investigate whether baseline optical coherence tomography (OCT parameters can predict the treatment frequency of intravitreal ranibizumab (IVR injections during the first year in patients with diabetic macular edema (DME treated with pro re nata (PRN IVR injections.We retrospectively reviewed 68 eyes of 63 patients with center-involved DME who received IVR injections for 12 months or longer according to three monthly IVR injections followed by the PRN dosing. We measured the mean retinal thicknesses in the individual subfields of the Early Treatment Diabetic Retinopathy Study grid and evaluated the qualitative and quantitative parameters on OCT sectional images. We investigated the relationship between these OCT parameters at baseline and the number of IVR injections during the 12-month follow-up.Three loading doses were administered to 10 eyes; four to seven annualized IVR injections were administered to 34 eyes. The number of eyes that received IVR injections decreased gradually until month 6 and was almost constant from months 7 to 11. No relationships were seen between the treatment frequency and baseline systemic factors and the ophthalmic examination findings. Univariate analyses showed that the number of IVR injections during the first year was associated with the mean retinal thickness in the individual subfields and the transverse length of the disrupted external limiting membrane (ELM and ellipsoid zone of the photoreceptors. Multivariate analysis showed a significant association with the thickness in the inferior subfield alone. The treatment frequency during the 12-month follow-up was not correlated with improved visual acuity but was associated with the decrease in the central subfield thickness and disrupted ELM.The retinal thickness in the inferior subfield predicts the treatment frequency during the first year in eyes with DME treated with PRN IVR injections.

  17. Twelve evidence-based principles for implementing self-management support in primary care.

    Science.gov (United States)

    Battersby, Malcolm; Von Korff, Michael; Schaefer, Judith; Davis, Connie; Ludman, Evette; Greene, Sarah M; Parkerton, Melissa; Wagner, Edward H

    2010-12-01

    Recommendations to improve self-management support and health outcomes for people with chronic conditions in primary care settings are provided on the basis of expert opinion supported by evidence for practices and processes. Practices and processes that could improve self-management support in primary care were identified through a nominal group process. In a targeted search strategy, reviews and meta-analyses were then identifed using terms from a wide range of chronic conditions and behavioral risk factors in combination with Self-Care, Self-Management, and Primary Care. On the basis of these reviews, evidence-based principles for self-management support were developed. The evidence is organized within the framework of the Chronic Care Model. Evidence-based principles in 12 areas were associated with improved patient self-management and/or health outcomes: (1) brief targeted assessment, (2) evidence-based information to guide shared decision-making, (3) use of a nonjudgmental approach, (4) collaborative priority and goal setting, (5) collaborative problem solving, (6) self-management support by diverse providers, (7) self-management interventions delivered by diverse formats, (8) patient self-efficacy, (9) active followup, (10) guideline-based case management for selected patients, (11) linkages to evidence-based community programs, and (12) multifaceted interventions. A framework is provided for implementing these principles in three phases of the primary care visit: enhanced previsit assessment, a focused clinical encounter, and expanded postvisit options. There is a growing evidence base for how self-management support for chronic conditions can be integrated into routine health care.

  18. Time Course of Improvement of Metabolic Parameters after a 12 Week Physical Exercise Programme in Patients with Type 2 Diabetes: The Influence of Gender in a Nigerian Population

    Directory of Open Access Journals (Sweden)

    A. F. Adeniyi

    2013-01-01

    Full Text Available Gender is a major determinant of the outcomes of many health interventions. This study documents the order of significant improvements in metabolic parameters of patients with type 2 diabetes mellitus (T2DM having metabolic syndrome within 12 weeks of physical exercise programmes. Twenty-nine patients, mean age 49.6 ± 3.7 years, presenting with high fasting plasma glucose, high triglycerides, hypertension, and high waist circumference undertook a thrice weekly aerobic and endurance exercise programme in addition to their drugs and diet. Variables were assessed at baseline and end of every two weeks for twelve weeks. Compared with baseline, significant improvement (P<0.05 in the metabolic parameters occurred in this order for the male participants: fasting glucose (2nd week, triglycerides and waist circumference (4th week, and systolic blood pressure (12th week. For the female participants, it was fasting glucose (4th week, triglycerides (6th week, and waist circumference (10th week. Regardless of the gender, fasting glucose was the first to improve significantly, followed by triglycerides. Hypertension did not improve significantly at all in the female participants as they may require more than twelve weeks of therapeutic exercise for any significant improvement in hypertension.

  19. 76 FR 52969 - In the Matter of Certain Protective Cases and Components Thereof Notice of Commission...

    Science.gov (United States)

    2011-08-24

    .... International Trade Commission has determined not to review the presiding administrative law judge's (``ALJ... named twenty nine respondents, including Cellaris Franchise, Inc. of Alpharetta, Georgia (``Cellaris...

  20. Safety and surgical techniques of C1 lateral mass screws

    International Nuclear Information System (INIS)

    Kubo, Shinichiro; Kuroki, Hiroshi; Hanado, Shoji; Hamanaka, Hideaki; Inomata, Naoki; Kuroki, Shuji; Chosa, Etsuo

    2010-01-01

    The objectives of this study were to evaluate the proper insertion techniques of C1 lateral mass screws. Eighteen consecutive patients were examined after upper cervical fusion using twenty-nine C1 lateral mass screws. Screws were placed by three different techniques; Goel's technique (4), Tan's technique (20), Notching technique (5). Pre and post-operative CT scans with multiplanar reconstruction were used to detect cortical breaches and direction of screws. No transverse foramen and vertebral groove violation was found in CT scans. Three had breached superior articular facet of the atlas. However, the range of motion (R.O.M) of atlanto-occipital joints had not changed postoperatively. Theses screws were inserted with Tan's technique and two of three were directed medially. It is feasible to safely insert C1 lateral mass screws when correct insertion point and direction are considered preoperatively. However, care should be taken because screws can violate the atlanto-occipital joint especially with Tan's technique. (author)

  1. [Self esteem, affectivity perception, aims, and risk behaviors among teenagers of both sexes].

    Science.gov (United States)

    Millán, T; Valenzuela, S; Vargas, N A

    1995-05-01

    A self applied and anonymous enquiry was answered by 948 teenagers (600 female), participating in an integral health education plan and coming from a school located in a low income community of Metropolitan Santiago. Twenty nine percent came from single or foster parent families and 18.4% of parents were separated. Nineteen percent of women and 9.8% of men felt that they were not loved by their parents; 30.5% of women and classified as bad or regular their relationship with their fathers and 22.1% of men similarly classified their relationship with their mothers. Eighteen percent of men and 16.5% of women ignored their parent's educational level. Ten to 24% had a negative self image and 50% were unsure about their study goals. Forty eight percent of men and 25.5% of women had get drunk; 24.1 and 12.8% had smoked marihuana. Half of the sample manifested attraction to dangerous situations; 22% had participated in quarrels and 34% had attacked other people. Twenty three percent of men and 35% of women had considered committing suicide. It is concluded that the lack of affection, a deteriorated self image, difficult parental relationships and orientation toward violence appear as the main problems in this sample of teenagers.

  2. Contemporary use of social media by consultant colorectal surgeons.

    Science.gov (United States)

    McDonald, J J; Bisset, C; Coleman, M G; Speake, D; Brady, R R W

    2015-02-01

    There is evidence of significant growth in the engagement of UK health-care professionals with 'open' social media platforms, such as Twitter and LinkedIn. Social media communication provides many opportunities and benefits for medical education and interaction with patients and colleagues. This study was undertaken to evaluate the uptake of public social media membership and the characteristics of use of such media channels amongst contemporary UK consultant colorectal surgeons. Colorectal surgeons were identified from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) national registry of colorectal mortality outcomes and were cross-referenced with the General Medical Council (GMC) register. Individuals were identified by manual searching on a number of social media platforms. Matching accounts were then examined to confirm ownership and to evaluate key markers of use. Six-hundred and eighteen individual consultant colorectal surgeons from 142 health authorities were studied (79.5% were ACPGBI members and 90.8% were male). Two-hundred and twenty-nine (37.1%) had LinkedIn profiles (37.7% male surgeons, 29.8% female surgeons; P = 0.2530). LinkedIn membership was significantly higher in ACPGBI members (P social media than reported studies from other health-care professional groups. Further education and appropriate guidance on usage may encourage uptake and confidence, particularly in younger consultants. Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland.

  3. Characterization of Trypanosoma cruzi Strains Isolated from Chronic Chagasic Patients, Triatomines and Opossums Naturally Infected from the State of Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Cloé Duarte Fernandes

    1997-05-01

    Full Text Available Thirty-five Trypanosoma cruzi strains were isolated from chronic chagasic patients, triatomines and opossums from different municipalities of the State of Rio Grande do Sul. Parasites were characterized by means of mice infectivity, enzyme electrophoresis and randomly amplified polymorphic DNA (RAPD analysis. Twenty-nine strains were isolated from chagasic patients, 4 from triatomines (2 from Triatoma infestans and 2 from Panstrongylus megistus and 2 from opossums Didelphis albiventris. Thirty-three T. cruzi strains were of low and 2 strains of high virulence in mice. Both virulent strains were isolated from P. megistus. Isoenzyme analysis of the strains showed 3 different zymodemes. Eleven strains isolated from chagasic patients and 2 from D. albiventris were Z2. Eighteen strains from patients and 2 from T. infestans were ZB and 2 T. cruzi strains isolated from P. megistus were Z1. RAPD profiles obtained with 4 random primers showed a high genetic heterogeneity of the T. cruzi strains. Zymodeme 2 and ZB strains were the more polymorphic. A band sharing analysis of the RAPD profiles of Z2 and ZB strains using 3 primers, showed a very low percentage of shared bands, 20% among 13 ZB strains and 14% among 13 Z2 strains. According to the isoenzyme results, 3 T. cruzi populations were present in State of Rio Grande do Sul. Zymodeme 2 and ZB strains were found infecting man (domiciliar transmission cycle whereas Z1 strains were found infecting the sylvatic vector P. megistus

  4. Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication

    International Nuclear Information System (INIS)

    Sayle, B.A.; Helmer, R.E.; Birdsong, B.A.; Balachandran, S.; Gardner, F.H.

    1982-01-01

    Twenty-nine patients with aplastic anemia and 11 patients with myelofibrosis were evaluated with indium-111 chloride bone-marrow imaging, ferrokinetics, and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the In-111 bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy had been taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was good correlation between the plasma iron clearance t1/2 and the scan grade. Less agreement was found in the comparison between the Fe-59 sacral and organ counts and the red-cell iron utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell iron utilization. Plasma iron clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics, and the patient's response to therapy. Indium-111 bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases

  5. Mutations in ABCR (ABCA4) in patients with Stargardt macular degeneration or cone-rod degeneration.

    Science.gov (United States)

    Briggs, C E; Rucinski, D; Rosenfeld, P J; Hirose, T; Berson, E L; Dryja, T P

    2001-09-01

    To determine the spectrum of ABCR mutations associated with Stargardt macular degeneration and cone-rod degeneration (CRD). One hundred eighteen unrelated patients with recessive Stargardt macular degeneration and eight with recessive CRD were screened for mutations in ABCR (ABCA4) by single-strand conformation polymorphism analysis. Variants were characterized by direct genomic sequencing. Segregation analysis was performed on the families of 20 patients in whom at least two or more likely pathogenic sequence changes were identified. The authors found 77 sequence changes likely to be pathogenic: 21 null mutations (15 novel), 55 missense changes (26 novel), and one deletion of a consensus glycosylation site (also novel). Fifty-two patients with Stargardt macular degeneration (44% of those screened) and five with CRD each had two of these sequence changes or were homozygous for one of them. Segregation analyses in the families of 19 of these patients were informative and revealed that the index cases and all available affected siblings were compound heterozygotes or homozygotes. The authors found one instance of an apparently de novo mutation, Ile824Thr, in a patient. Thirty-seven (31%) of the 118 patients with Stargardt disease and one with CRD had only one likely pathogenic sequence change. Twenty-nine patients with Stargardt disease (25%) and two with CRD had no identified sequence changes. This report of 42 novel mutations brings the growing number of identified likely pathogenic sequence changes in ABCR to approximately 250.

  6. Obstructive jaundice and advanced gastric carcinoma

    International Nuclear Information System (INIS)

    Saida, Yukihisa; Tsunoda, Hiroko; Kurosaki, Yoshihisa

    1989-01-01

    One hundred twenty-nine patients with far advanced or recurrent gastric carcinoma underwent computed tomography (CT) of the abdomen. There were three histologic types: differentiated (n=41), undifferentiated (n=68), and unclassified (n=20). Eighteen patients who had developed obstructive jaundice were retrospectively studied to elucidate the nature of obstruction with histologic correlation. In differentiated carcinomas tumor tended to grow in an expansive fashion. A fairly large, well-defined lymph adenopathy was observed on CT. The extrahepatic bile duct surrounded by lymph nodes appeared as ''doughnot sign'' in six of eight patients. Undifferentiated gastric carcinoma had tendency to extend infiltratively. Bile duct obstruction was only a part of diffuse spreading. In spite of the presence of obstructive jaundice, no discrete mass was demonstrated around the extrahepatic bile duct on CT. In none of nine patients was present ''doughnot sign''. The significance of lymph node dissection along the extrahepatic bile duct in patients with differentiated gastric carcinoma was emphasized. The region of hepatoduodenal and pancreatico-duodenal lymph nodes should be carefully evaluated in interpretation of abdominal CT. (author)

  7. Executive function deficits in team sport athletes with a history of concussion revealed by a visual-auditory dual task paradigm.

    Science.gov (United States)

    Tapper, Anthony; Gonzalez, Dave; Roy, Eric; Niechwiej-Szwedo, Ewa

    2017-02-01

    The purpose of this study was to examine executive functions in team sport athletes with and without a history of concussion. Executive functions comprise many cognitive processes including, working memory, attention and multi-tasking. Past research has shown that concussions cause difficulties in vestibular-visual and vestibular-auditory dual-tasking, however, visual-auditory tasks have been examined rarely. Twenty-nine intercollegiate varsity ice hockey athletes (age = 19.13, SD = 1.56; 15 females) performed an experimental dual-task paradigm that required simultaneously processing visual and auditory information. A brief interview, event description and self-report questionnaires were used to assign participants to each group (concussion, no-concussion). Eighteen athletes had a history of concussion and 11 had no concussion history. The two tests involved visuospatial working memory (i.e., Corsi block test) and auditory tone discrimination. Participants completed both tasks individually, then simultaneously. Two outcome variables were measured, Corsi block memory span and auditory tone discrimination accuracy. No differences were shown when each task was performed alone; however, athletes with a history of concussion had a significantly worse performance on the tone discrimination task in the dual-task condition. In conclusion, long-term deficits in executive functions were associated with a prior history of concussion when cognitive resources were stressed. Evaluations of executive functions and divided attention appear to be helpful in discriminating participants with and without a history concussion.

  8. Quality of life domains important and relevant to family caregivers of advanced cancer patients in an Asian population: a qualitative study.

    Science.gov (United States)

    Lee, Geok Ling; Ow, Mandy Yen Ling; Akhileswaran, Ramaswamy; Pang, Grace Su Yin; Fan, Gilbert Kam Tong; Goh, Brandon Huat Heng; Wong, Cai Fong; Cheung, Yin Bun; Wee, Hwee Lin

    2015-04-01

    This study aims to identify domains of quality of life (QoL) that are culturally relevant to Chinese caregivers of advanced cancer patients in Singapore and to evaluate content adequacy of currently available instruments for use in the target population. English- and Chinese-speaking caregivers of advanced cancer patients receiving care under a tertiary cancer center and/or a community hospice home care/day care provider were recruited for in-depth interviews. The interviews were analyzed using thematic analysis. The identified domains, themes and sub-themes were compared to concepts addressed by items from five existing cancer-specific caregiver QoL instruments. Eighteen female and eight male caregivers aged 28-74 years participated in the study. Twenty-nine QoL themes and 59 sub-themes were identified in six domains, namely physical health, mental health, social health, spiritual health, financial health and daily life. Collectively, but not individually, the content of the five existing instruments adequately cover the physical health domain, social health domain and some themes on mental health domain for the study population. Content gaps were identified in the domains of mental health, spiritual health, daily life and financial health. The present study found culturally and contextually specific themes and sub-themes about positive emotional health, spiritual health and financial health.

  9. Report made on the behalf of the Foreign Affairs Commission on the bill project nr 2932 authorizing the ratification of the protocol modifying the protocol on transitory dispositions attached to the Treaty on the European Union, to the Treaty on the functioning of the European Union, and to the Treaty establishing the European Atomic Energy Community; Rapport fait au nom de la Commission des Affaires Etrangeres sur le Projet de Loi n. 2932, autorisant la ratification du protocole modifiant le protocole sur les dispositions transitoires annexe au traite sur l'Union europeenne, au traite sur le fonctionnement de l'Union europeenne et au traite instituant la Communaute europeenne de l'energie atomique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This report first describes and comments the consequences of the Lisbon Treaty in terms of composition for the European Parliament, and more particularly the debate about the design of an efficient and representative parliament, the election mode and the seat distribution. Then, it describes how the modification protocol has been elaborated, its content (general architecture, eighteen additional seats for twelve member States and their election modalities), and its implementation (agenda and method)

  10. Trace content of uranium in spices and condiments

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Y P; Lal, N; Mahesh, K; Nagpaul, K K [Regional Engineering Coll., Kurukshetra (India). Dept. of Physics; Chakarvarti, S K [Kurukshetra Univ. (India). Dept. of Physics

    1981-10-01

    The natural uranium trace contents of eighteen spice and condiment samples belonging to twelve different plant families in India were determined by the fission track etch technique. The uranium contents varied from 0.28 +- 0.002 to 78.6 +- 0.50 pg/g. This does not pose a serious health hazard since the permissible limit intake by humans is 40 mg/day.

  11. Report made on the behalf of the Foreign Affairs Commission on the bill project nr 2932 authorizing the ratification of the protocol modifying the protocol on transitory dispositions attached to the Treaty on the European Union, to the Treaty on the functioning of the European Union, and to the Treaty establishing the European Atomic Energy Community

    International Nuclear Information System (INIS)

    2011-01-01

    This report first describes and comments the consequences of the Lisbon Treaty in terms of composition for the European Parliament, and more particularly the debate about the design of an efficient and representative parliament, the election mode and the seat distribution. Then, it describes how the modification protocol has been elaborated, its content (general architecture, eighteen additional seats for twelve member States and their election modalities), and its implementation (agenda and method)

  12. Early Gender Gaps among University Graduates

    OpenAIRE

    Francesconi, Marco; Parey, Matthias

    2018-01-01

    We use data from six cohorts of university graduates in Germany to assess the extent of gender gaps in college and labor market performance twelve to eighteen months after graduation. Men and women enter college in roughly equal numbers, but more women than men complete their degrees. Women enter college with slightly better high school grades, but women leave university with slightly lower marks. Immediately following university completion, male and female full-timers work very similar numbe...

  13. Variation in density of cattle-visiting muscid flies between Danish inland pastures

    DEFF Research Database (Denmark)

    Jensen, Karl-Martin Vagn; Jespersen, Jørgen B.; Nielsen, B. Overgaard

    1993-01-01

    The density of cattle-visiting flies (Muscidae) and the load of black-flies (Simulium spp.) were estimated in twelve and eighteen inland pastures in Denmark in 1984 and 1985 respectively. No differences in the geographical distribution pattern of the predominant cattle-visiting Muscidae were reco......-exposed pastures. A comparable relationship was found for Haematobia irritans. With Haematobosca stimulans (Mg.) and Morellia spp. no relation between grassland environment and fly density was detected....

  14. Comparison of photoacclimation in twelve freshwater photoautotrophs (chlorophyte, bacillaryophyte, cryptophyte and cyanophyte isolated from a natural community.

    Directory of Open Access Journals (Sweden)

    Charles P Deblois

    Full Text Available Different representative of algae and cyanobacteria were isolated from a freshwater habitat and cultivated in laboratory to compare their photoacclimation capacity when exposed to a wide range of light intensity and to understand if this factor may modify natural community dominance. All species successfully acclimated to all light intensities and the response of phytoplankton to increased light intensity was similar and included a decrease of most photosynthetic pigments accompanied by an increase in photoprotective pigment content relative to Chl a. Most species also decreased their light absorption efficiency on a biovolume basis. This decrease not only resulted in a lower fraction of energy absorbed by the cell, but also to a lower transfer of energy to PSII and PSI. Furthermore, energy funnelled to PSII or PSI was also rearranged in favour of PSII. High light acclimated organisms also corresponded to high non-photochemical quenching and photosynthetic electron transport reduction state and to a low Φ'M. Thus photoacclimation processes work toward reducing the excitation pressure in high light environment through a reduction of light absorption efficiency, but also by lowering conversion efficiency. Interestingly, all species of our study followed that tendency despite being of different functional groups (colonial, flagellated, different sizes and of different phylogeny demonstrating the great plasticity and adaptation ability of freshwater phytoplankton to their light environment. These adjustments may explain the decoupling between growth rate and photosynthesis observed above photosynthesis light saturation point for all species. Even if some species did reach higher growth rate in our conditions and thus, should dominate in natural environment with respect to light intensity, we cannot exclude that other environmental factors also influence the population dynamic and make the outcome harder to predict.

  15. Twelve tips for a successful workplace-based masters programme in geriatric for specialist registrars and specialty trainees.

    Science.gov (United States)

    Bhat, Sarita; Baker, Paul; Eyres, Renata

    2008-01-01

    Postgraduate medical training is undergoing major change, shortening and disrupting traditional practices. Scholarship remains highly valued, but increasingly difficult to fit in. Workplace-based Masters study offers a solution. We want consultants who are driven by enquiry, good teachers and team workers. Academic qualifications demonstrate trainees' commitment and expertise in competitive employment markets. Most Deaneries allow two sessions weekly for research/personal development, so this resource demands effective use. The good will, talent and commitment of colleagues are vital. A credible structured curriculum combines real-life consultant-level generic practice, with technical medical skills. Academic writing and practical assignments are assessed. Linking with a far-sighted academic institution brings vast expertise in education administration and delivery of accredited learning. The course is more cost-effective than traditional study leave activities. Running part-time over 4 years fits with Higher Specialist Training. Structured programmes, over 9 month 'terms', fit with clinical rotations. Module leaders run yearly clinical modules alongside continuous generic modules. Clinical units are signed up to releasing trainees to attend. Evaluation is external to faculty, with highly favourable feedback. We believe training in academic disciplines underpins practice. With strong partnership working, planning and especially hard work, such a course is deliverable.

  16. Twelve-month quality of life improvement and all-cause mortality in elderly patients undergoing transcatheter aortic valve replacement.

    Science.gov (United States)

    Kleczyński, Paweł; Bagieński, Maciej; Dziewierz, Artur; Rzeszutko, Łukasz; Sorysz, Danuta; Trębacz, Jarosław; Sobczyński, Robert; Tomala, Marek; Stąpór, Maciej; Dudek, Dariusz

    2016-10-10

    Restoration of quality of life (QoL) and improvement of clinical outcomes is crucial in elderly patients undergoing transcatheter aortic valve implantation (TAVI). We sought to evaluate changes in QoL and all-cause mortality 12 months after TAVI. A total of 101 patients who underwent TAVI were included. Patients were followed for 12 months. QoL was assessed at baseline and at 1, 6 and 12 months after TAVI using EQ-5D-3L with a visual analog scale (VAS). Patients who reported some problems with mobility at baseline showed better mobility after 12 months (p = 0.001). On the other hand, those who reported issues with self-care, usual activity or pain did not show significant improvement (p = 0.41; p = 0.12; p = 0.27, respectively). Patients reporting anxiety at baseline improved 12 months later (p = 0.003). VAS score showed an incremental increase during follow-up (p<0.001). Transfemoral access was associated with higher VAS score values after 1 month (median (IQR): 65.0 (50.0-75.0) vs. 54.0 (50.0-60.0); p = 0.019) but not after 12 months (70.0 (62.5-80.0) vs. 67.5 (55.0-70.0); p = 0.07) as compared to non-transfemoral access. In multivariable regression analysis, only age and the presence of coronary chronic total occlusion were independently associated with VAS score at 12 months. In-hospital, 1-, 6- and 12-month mortality rates were 6.9%, 10.9%, 15.8 and 17.8%, respectively. TAVI provides improved QoL with relatively good clinical outcomes. However, not all components of QoL may be improved. Patients treated with transfemoral access might have better QoL than those who had non-transfemoral access, especially early after TAVI.

  17. Twelve years' experience with direct-to-consumer advertising of prescription drugs in Canada: a cautionary tale.

    Directory of Open Access Journals (Sweden)

    Barbara Mintzes

    2009-05-01

    Full Text Available Direct-to-consumer advertising (DTCA of prescription drugs is illegal in Canada as a health protection measure, but is permitted in the United States. However, in 2000, Canadian policy was changed to allow 'reminder' advertising of prescription drugs. This is a form of advertising that states the brand name without health claims. 'Reminder' advertising is prohibited in the US for drugs that have 'black box' warnings of serious risks. This study examines spending on DTCA in Canada from 1995 to 2006, 12 years spanning this policy shift. We ask how annual per capita spending compares to that in the US, and whether drugs with Canadian or US regulatory safety warnings are advertised to the Canadian public in reminder advertising.Prescription drug advertising spending data were extracted from a data set on health sector spending in Canada obtained from a market research company, TNS Media Inc. Spending was adjusted for inflation and compared with US spending. Inflation-adjusted spending on branded DTCA in Canada grew from under CAD$2 million per year before 1999 to over $22 million in 2006. The major growth was in broadcast advertising, accounting for 83% of spending in 2006. US annual per capita spending was on average 24 times Canadian levels. Celebrex (celecoxib, which has a US black box and was subject to three safety advisories in Canada, was the most heavily advertised drug on Canadian television in 2005 and 2006. Of 8 brands with >$500,000 spending, which together accounted for 59% of branded DTCA in all media, 6 were subject to Canadian safety advisories, and 4 had US black box warnings.Branded 'reminder' advertising has grown rapidly in Canada since 2000, mainly due to a growth in television advertising. Although DTCA spending per capita is much lower in Canada than in the US, there is no evidence of safer content or product choice; many heavily-advertised drugs in Canada have been subject to safety advisories. For governments searching for compromise solutions to industry pressure for expanded advertising, Canada's experience stands as a stark warning.

  18. Twelve years' experience with direct-to-consumer advertising of prescription drugs in Canada: a cautionary tale.

    Science.gov (United States)

    Mintzes, Barbara; Morgan, Steve; Wright, James M

    2009-05-27

    Direct-to-consumer advertising (DTCA) of prescription drugs is illegal in Canada as a health protection measure, but is permitted in the United States. However, in 2000, Canadian policy was changed to allow 'reminder' advertising of prescription drugs. This is a form of advertising that states the brand name without health claims. 'Reminder' advertising is prohibited in the US for drugs that have 'black box' warnings of serious risks. This study examines spending on DTCA in Canada from 1995 to 2006, 12 years spanning this policy shift. We ask how annual per capita spending compares to that in the US, and whether drugs with Canadian or US regulatory safety warnings are advertised to the Canadian public in reminder advertising. Prescription drug advertising spending data were extracted from a data set on health sector spending in Canada obtained from a market research company, TNS Media Inc. Spending was adjusted for inflation and compared with US spending. Inflation-adjusted spending on branded DTCA in Canada grew from under CAD$2 million per year before 1999 to over $22 million in 2006. The major growth was in broadcast advertising, accounting for 83% of spending in 2006. US annual per capita spending was on average 24 times Canadian levels. Celebrex (celecoxib), which has a US black box and was subject to three safety advisories in Canada, was the most heavily advertised drug on Canadian television in 2005 and 2006. Of 8 brands with >$500,000 spending, which together accounted for 59% of branded DTCA in all media, 6 were subject to Canadian safety advisories, and 4 had US black box warnings. Branded 'reminder' advertising has grown rapidly in Canada since 2000, mainly due to a growth in television advertising. Although DTCA spending per capita is much lower in Canada than in the US, there is no evidence of safer content or product choice; many heavily-advertised drugs in Canada have been subject to safety advisories. For governments searching for compromise solutions to industry pressure for expanded advertising, Canada's experience stands as a stark warning.

  19. An ultraluminous quasar with a twelve-billion-solar-mass black hole at redshift 6.30.

    Science.gov (United States)

    Wu, Xue-Bing; Wang, Feige; Fan, Xiaohui; Yi, Weimin; Zuo, Wenwen; Bian, Fuyan; Jiang, Linhua; McGreer, Ian D; Wang, Ran; Yang, Jinyi; Yang, Qian; Thompson, David; Beletsky, Yuri

    2015-02-26

    So far, roughly 40 quasars with redshifts greater than z = 6 have been discovered. Each quasar contains a black hole with a mass of about one billion solar masses (10(9) M Sun symbol). The existence of such black holes when the Universe was less than one billion years old presents substantial challenges to theories of the formation and growth of black holes and the coevolution of black holes and galaxies. Here we report the discovery of an ultraluminous quasar, SDSS J010013.02+280225.8, at redshift z = 6.30. It has an optical and near-infrared luminosity a few times greater than those of previously known z > 6 quasars. On the basis of the deep absorption trough on the blue side of the Lyman-α emission line in the spectrum, we estimate the proper size of the ionized proximity zone associated with the quasar to be about 26 million light years, larger than found with other z > 6.1 quasars with lower luminosities. We estimate (on the basis of a near-infrared spectrum) that the black hole has a mass of ∼1.2 × 10(10) M Sun symbol, which is consistent with the 1.3 × 10(10) M Sun symbol derived by assuming an Eddington-limited accretion rate.

  20. Equipping family physician trainees as teachers: a qualitative evaluation of a twelve-week module on teaching and learning.

    Science.gov (United States)

    de Villiers, Marietjie R; Cilliers, Francois J; Coetzee, Francois; Herman, Nicoline; van Heusden, Martie; von Pressentin, Klaus B

    2014-10-22

    There is a dire need to expand the capacity of institutions in Africa to educate health care professionals. Family physicians, as skilled all-rounders at district level, are potentially well placed to contribute to an extended training platform in this context. To play this role, they need to both have an understanding of their specialist role that incorporates teaching and be equipped for their role as trainers of current and future health workers and specialists. A teaching and learning capacity-building module was introduced into a new master's programme in family medicine at Stellenbosch University, South Africa. We report on the influence of this module on graduates after the first six years. A qualitative study was undertaken, interviewing thirteen graduates of the programme. Thematic analysis of data was done by a team comprising tutors and graduates of the programme and an independent researcher. Ethical clearance was obtained. The module influenced knowledge, skills and attitudes of respondents. Perceptions and evidence of changes in behaviour, changes in practice beyond the individual respondent and benefits to students and patients were apparent. Factors underlying these changes included the role of context and the role of personal factors. Contextual factors included clinical workload and opportunity pressure i.e., the pressure and responsibility to undertake teaching. Personal factors comprised self-confidence, modified attitudes and perceptions towards the roles of a family physician and towards learning and teaching, in addition to the acquisition of knowledge and skills in teaching and learning. The interaction between opportunity pressure and self-confidence influenced the application of what was learned about teaching. A module on teaching and learning influenced graduates' perceptions of, and self-reported behaviour relating to, teaching as practicing family physicians. This has important implications for educating family physicians in and for Africa and indirectly on expanding capacity to educate health care professionals in Africa.