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Sample records for turbomachinery design quality

  1. Turbomachinery Design Quality Checks to Avoid Friction Induced Structural Failure

    Science.gov (United States)

    Moore, Jerry H.

    1999-01-01

    A unique configuration of the P&W SSME Alternate Fuel Turbopump turbine disk/blade assembly, combined with a severe thermal environment, resulted in several structural anomalies that were driven by frictional contact forces. Understanding the mechanics of these problems provides new quality checks for future turbo machinery designs. During development testing in 1997 of the SSME alternate fuel turbopump at Stennis Space Center, several potentially serious problems surfaced with the turbine disk/blade assembly that had not been experienced in extensive earlier testing. Changes to the operational thermal environment were noted based on analytical prediction of modifications that affected performance and on stationary thermal measurements adjacent to the rotor assembly. A detailed structural investigation was required to reveal the mechanism of distress induced by the change. The turbine disk experienced cracking in several locations due to increased thermal gradient induced stress during start and shutdown transients. This was easily predictable using standard analysis procedures and expected once the thermal environment was characterized. What was not expected was the curling of a piston ring used for blade axial retention in the disk, indentation of the axial face of the blade attachment by a spacer separating the first and second stage blades, and most significantly, galling and cracking of the blade root attachment that could have resulted in blade release. Past experience, in gas turbine environments, set a precedent of never relying on friction for help and to evaluate it only in specific instances where it was obvious that it would degrade capability. In each of the three cases above, friction proved to be a determining factor that pushed the components into an unsatisfactory mode of operation. The higher than expected temperatures and rapid thermal transients combined with friction to move beyond past experience. The turbine disk/blade assembly configuration

  2. Active subspaces for the optimal meanline design of unconventional turbomachinery

    NARCIS (Netherlands)

    Bahamonde Noriega, Juan S.; Pini, M.; de Servi, C.M.; Colonna di Paliano, Piero

    2017-01-01

    The preliminary fluid dynamic design of turbomachinery operating with non-standard working fluids and unusual operating conditions and specifications can be very challenging because of the lack of know-how and guidelines. Examples are the design of turbomachinery for small-capacity organic

  3. Review of design optimization methods for turbomachinery aerodynamics

    Science.gov (United States)

    Li, Zhihui; Zheng, Xinqian

    2017-08-01

    In today's competitive environment, new turbomachinery designs need to be not only more efficient, quieter, and ;greener; but also need to be developed at on much shorter time scales and at lower costs. A number of advanced optimization strategies have been developed to achieve these requirements. This paper reviews recent progress in turbomachinery design optimization to solve real-world aerodynamic problems, especially for compressors and turbines. This review covers the following topics that are important for optimizing turbomachinery designs. (1) optimization methods, (2) stochastic optimization combined with blade parameterization methods and the design of experiment methods, (3) gradient-based optimization methods for compressors and turbines and (4) data mining techniques for Pareto Fronts. We also present our own insights regarding the current research trends and the future optimization of turbomachinery designs.

  4. Aerothermodynamics of turbomachinery: analysis and design

    National Research Council Canada - National Science Library

    Chen, Naixing

    2010-01-01

    ... Force 2.3.4 Rates of Work Done by the Viscous Stresses and Dissipation Function 2.3.5 Heat Transfer Term 2.4 Examples of Simplification of Viscous and Heat Transfer Terms 2.4.1 Three-Dimensional Flow in Turbomachinery Expressed by Using Arbitrary Non-Orthogonal Coordinates S1 Stream-Surface Flow S2 Stream-Surface Flow Annulus Wall Boundary L...

  5. Challenges and progress in turbomachinery design systems

    International Nuclear Information System (INIS)

    Van den Braembussche, R A

    2013-01-01

    This paper first describes the requirements that a modern design system should meet, followed by a comparison between design systems based on inverse design or optimization techniques. The second part of the paper presents the way these challenges are realized in an optimization method combining an Evolutionary theory and a Metamodel. Extensions to multi-disciplinary, multi-point and multi-objective optimization are illustrated by examples

  6. Turbomachinery. Vol. 1. Design and function. 6. rev. ed.

    International Nuclear Information System (INIS)

    Bohl, W.

    1994-01-01

    The basic technical manual contains the following main chapters: Main operating data of turbomachinery, energy conversion in the rotor, model laws and characteristics, cavitation, supersonic limit, water turbines, gas turbines, rotary pumps, fans, blowers, compressors, hydrodynamic couplings and transmissions, and operational behaviour of turbomachinery (performance characteristics). Basic knowledge in mathematics, fluid mechanics, thermodynamics, and technical mechanics is required to understand the subject matter. Little use is made of differential calculus and integral calculus. (orig.) [de

  7. SSME Investment in Turbomachinery Inducer Impeller Design Tools and Methodology

    Science.gov (United States)

    Zoladz, Thomas; Mitchell, William; Lunde, Kevin

    2010-01-01

    Within the rocket engine industry, SSME turbomachines are the de facto standards of success with regard to meeting aggressive performance requirements under challenging operational environments. Over the Shuttle era, SSME has invested heavily in our national inducer impeller design infrastructure. While both low and high pressure turbopump failures/anomaly resolution efforts spurred some of these investments, the SSME program was a major benefactor of key areas of turbomachinery inducer-impeller research outside of flight manifest pressures. Over the past several decades, key turbopump internal environments have been interrogated via highly instrumented hot-fire and cold-flow testing. Likewise, SSME has sponsored the advancement of time accurate and cavitating inducer impeller computation fluid dynamics (CFD) tools. These investments together have led to a better understanding of the complex internal flow fields within aggressive high performing inducers and impellers. New design tools and methodologies have evolved which intend to provide confident blade designs which strike an appropriate balance between performance and self induced load management.

  8. Supercritical Carbon Dioxide turbomachinery design for water-cooled Small Modular Reactor application

    International Nuclear Information System (INIS)

    Lee, Jekyoung; Lee, Jeong Ik; Yoon, Ho Joon; Cha, Jae Eun

    2014-01-01

    Highlights: • We described the concept of coupling the S-CO 2 Brayton cycle to the water-cooled SMRs. • We describe a turbomachinery design code called KAISD T MD that can use real gases too. • We suggest changes to the S-CO 2 cycle layout with multiple-independent shafts. • KAIST T MD was used to design the turbomachinery of suggested layout. - Abstract: The Supercritical Carbon Dioxide (S-CO 2 ) Brayton cycle has been gaining attention due to its compactness and high efficiency at moderate turbine inlet temperature. Previous S-CO 2 cycle research works in the field of nuclear engineering were focused on its application to the next generation reactor with higher turbine inlet temperature than the existing conventional water-cooled nuclear power plants. However, it was shown in authors’ previous paper that the advantages of the S-CO 2 Brayton cycle can be also further applied to the water-cooled Small Modular Reactor (SMR) with a success, since SMR requires minimal overall footprint while retaining high performance. One of the major issues in the S-CO 2 Brayton cycle is the selection and design of appropriate turbomachinery for the designed cycle. Because most of the nuclear industry uses incompressible working fluids or ideal gases in the turbomachinery, a more detailed examination of the design of the turbomachinery is required for a power system that uses S-CO 2 as working fluid. This is because the S-CO 2 Brayton cycle high efficiency is the result of the non-ideal variation of properties near the CO 2 critical point. Thus, the major focus of this paper is to suggest the design of the turbomachinery necessary for the S-CO 2 Brayton cycle coupled to water cooled SMRs. For this reason, a S-CO 2 Brayton cycle turbomachinery design methodology was suggested and the suggested design methodology was first tested with the existing experimental data to verify its capability. After then, it was applied to the proposed reference system to demonstrate its

  9. Supercritical Carbon Dioxide turbomachinery design for water-cooled Small Modular Reactor application

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jekyoung, E-mail: leejaeky85@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Lee, Jeong Ik, E-mail: jeongiklee@kaist.ac.kr [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Yoon, Ho Joon, E-mail: hojoon.yoon@kustar.ac.ae [Khalifa University of Science, Technology and Research (KUSTAR), P.O. Box 127788, Abu Dhabi (United Arab Emirates); Cha, Jae Eun, E-mail: jecha@kaeri.re.kr [Korea Atomic Energy Research Institute, 1045 Daedeok-daero, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)

    2014-04-01

    Highlights: • We described the concept of coupling the S-CO{sub 2} Brayton cycle to the water-cooled SMRs. • We describe a turbomachinery design code called KAISD{sub T}MD that can use real gases too. • We suggest changes to the S-CO{sub 2} cycle layout with multiple-independent shafts. • KAIST{sub T}MD was used to design the turbomachinery of suggested layout. - Abstract: The Supercritical Carbon Dioxide (S-CO{sub 2}) Brayton cycle has been gaining attention due to its compactness and high efficiency at moderate turbine inlet temperature. Previous S-CO{sub 2} cycle research works in the field of nuclear engineering were focused on its application to the next generation reactor with higher turbine inlet temperature than the existing conventional water-cooled nuclear power plants. However, it was shown in authors’ previous paper that the advantages of the S-CO{sub 2} Brayton cycle can be also further applied to the water-cooled Small Modular Reactor (SMR) with a success, since SMR requires minimal overall footprint while retaining high performance. One of the major issues in the S-CO{sub 2} Brayton cycle is the selection and design of appropriate turbomachinery for the designed cycle. Because most of the nuclear industry uses incompressible working fluids or ideal gases in the turbomachinery, a more detailed examination of the design of the turbomachinery is required for a power system that uses S-CO{sub 2} as working fluid. This is because the S-CO{sub 2} Brayton cycle high efficiency is the result of the non-ideal variation of properties near the CO{sub 2} critical point. Thus, the major focus of this paper is to suggest the design of the turbomachinery necessary for the S-CO{sub 2} Brayton cycle coupled to water cooled SMRs. For this reason, a S-CO{sub 2} Brayton cycle turbomachinery design methodology was suggested and the suggested design methodology was first tested with the existing experimental data to verify its capability. After then, it was

  10. GPU-accelerated CFD Simulations for Turbomachinery Design Optimization

    NARCIS (Netherlands)

    Aissa, M.H.

    2017-01-01

    Design optimization relies heavily on time-consuming simulations, especially when using gradient-free optimization methods. These methods require a large number of simulations in order to get a remarkable improvement over reference designs, which are nowadays based on the accumulated engineering

  11. Turbomachinery design for Rankine cycles in waste heat recovery applications

    OpenAIRE

    Agromayor Otero, Roberto

    2017-01-01

    Rankine Cycles are an effective and efficient manner to convert waste thermal energy into power. Numerous fluids can be used in Rankine cycles, including water, hydrocarbons, hydrofluorocarbons, siloxanes, alcohols or even mixtures of fluids. The performance of Rankine cycles is highly dependent on the optimization of the operating conditions and the design of its components. The expander is, perhaps, the most important component of the Rankine cycle, as it is the device where the energy of t...

  12. Design of an Object-Oriented Turbomachinery Analysis Code: Initial Results

    Science.gov (United States)

    Jones, Scott M.

    2015-01-01

    Performance prediction of turbomachines is a significant part of aircraft propulsion design. In the conceptual design stage, there is an important need to quantify compressor and turbine aerodynamic performance and develop initial geometry parameters at the 2-D level prior to more extensive Computational Fluid Dynamics (CFD) analyses. The Object-oriented Turbomachinery Analysis Code (OTAC) is being developed to perform 2-D meridional flowthrough analysis of turbomachines using an implicit formulation of the governing equations to solve for the conditions at the exit of each blade row. OTAC is designed to perform meanline or streamline calculations; for streamline analyses simple radial equilibrium is used as a governing equation to solve for spanwise property variations. While the goal for OTAC is to allow simulation of physical effects and architectural features unavailable in other existing codes, it must first prove capable of performing calculations for conventional turbomachines. OTAC is being developed using the interpreted language features available in the Numerical Propulsion System Simulation (NPSS) code described by Claus et al (1991). Using the NPSS framework came with several distinct advantages, including access to the pre-existing NPSS thermodynamic property packages and the NPSS Newton-Raphson solver. The remaining objects necessary for OTAC were written in the NPSS framework interpreted language. These new objects form the core of OTAC and are the BladeRow, BladeSegment, TransitionSection, Expander, Reducer, and OTACstart Elements. The BladeRow and BladeSegment consumed the initial bulk of the development effort and required determining the equations applicable to flow through turbomachinery blade rows given specific assumptions about the nature of that flow. Once these objects were completed, OTAC was tested and found to agree with existing solutions from other codes; these tests included various meanline and streamline comparisons of axial

  13. Design optimization and uncertainty quantification for aeromechanics forced response of a turbomachinery blade

    Science.gov (United States)

    Modgil, Girish A.

    Gas turbine engines for aerospace applications have evolved dramatically over the last 50 years through the constant pursuit for better specific fuel consumption, higher thrust-to-weight ratio, lower noise and emissions all while maintaining reliability and affordability. An important step in enabling these improvements is a forced response aeromechanics analysis involving structural dynamics and aerodynamics of the turbine. It is well documented that forced response vibration is a very critical problem in aircraft engine design, causing High Cycle Fatigue (HCF). Pushing the envelope on engine design has led to increased forced response problems and subsequently an increased risk of HCF failure. Forced response analysis is used to assess design feasibility of turbine blades for HCF using a material limit boundary set by the Goodman Diagram envelope that combines the effects of steady and vibratory stresses. Forced response analysis is computationally expensive, time consuming and requires multi-domain experts to finalize a result. As a consequence, high-fidelity aeromechanics analysis is performed deterministically and is usually done at the end of the blade design process when it is very costly to make significant changes to geometry or aerodynamic design. To address uncertainties in the system (engine operating point, temperature distribution, mistuning, etc.) and variability in material properties, designers apply conservative safety factors in the traditional deterministic approach, which leads to bulky designs. Moreover, using a deterministic approach does not provide a calculated risk of HCF failure. This thesis describes a process that begins with the optimal aerodynamic design of a turbomachinery blade developed using surrogate models of high-fidelity analyses. The resulting optimal blade undergoes probabilistic evaluation to generate aeromechanics results that provide a calculated likelihood of failure from HCF. An existing Rolls-Royce High Work Single

  14. Development of multidisciplinary design optimization procedures for smart composite wings and turbomachinery blades

    Science.gov (United States)

    Jha, Ratneshwar

    Multidisciplinary design optimization (MDO) procedures have been developed for smart composite wings and turbomachinery blades. The analysis and optimization methods used are computationally efficient and sufficiently rigorous. Therefore, the developed MDO procedures are well suited for actual design applications. The optimization procedure for the conceptual design of composite aircraft wings with surface bonded piezoelectric actuators involves the coupling of structural mechanics, aeroelasticity, aerodynamics and controls. The load carrying member of the wing is represented as a single-celled composite box beam. Each wall of the box beam is analyzed as a composite laminate using a refined higher-order displacement field to account for the variations in transverse shear stresses through the thickness. Therefore, the model is applicable for the analysis of composite wings of arbitrary thickness. Detailed structural modeling issues associated with piezoelectric actuation of composite structures are considered. The governing equations of motion are solved using the finite element method to analyze practical wing geometries. Three-dimensional aerodynamic computations are performed using a panel code based on the constant-pressure lifting surface method to obtain steady and unsteady forces. The Laplace domain method of aeroelastic analysis produces root-loci of the system which gives an insight into the physical phenomena leading to flutter/divergence and can be efficiently integrated within an optimization procedure. The significance of the refined higher-order displacement field on the aeroelastic stability of composite wings has been established. The effect of composite ply orientations on flutter and divergence speeds has been studied. The Kreisselmeier-Steinhauser (K-S) function approach is used to efficiently integrate the objective functions and constraints into a single envelope function. The resulting unconstrained optimization problem is solved using the

  15. A General Multidisciplinary Turbomachinery Design Optimization system Applied to a Transonic Fan

    Science.gov (United States)

    Nemnem, Ahmed Mohamed Farid

    The blade geometry design process is integral to the development and advancement of compressors and turbines in gas generators or aeroengines. A new airfoil section design capability has been added to an open source parametric 3D blade design tool. Curvature of the meanline is controlled using B-splines to create the airfoils. The curvature is analytically integrated to derive the angles and the meanline is obtained by integrating the angles. A smooth thickness distribution is then added to the airfoil to guarantee a smooth shape while maintaining a prescribed thickness distribution. A leading edge B-spline definition has also been implemented to achieve customized airfoil leading edges which guarantees smoothness with parametric eccentricity and droop. An automated turbomachinery design and optimization system has been created. An existing splittered transonic fan is used as a test and reference case. This design was more general than a conventional design to have access to the other design methodology. The whole mechanical and aerodynamic design loops are automated for the optimization process. The flow path and the geometrical properties of the rotor are initially created using the axi-symmetric design and analysis code (T-AXI). The main and splitter blades are parametrically designed with the created geometry builder (3DBGB) using the new added features (curvature technique). The solid model creation of the rotor sector with a periodic boundaries combining the main blade and splitter is done using MATLAB code directly connected to SolidWorks including the hub, fillets and tip clearance. A mechanical optimization is performed with DAKOTA (developed by DOE) to reduce the mass of the blades while keeping maximum stress as a constraint with a safety factor. A Genetic algorithm followed by Numerical Gradient optimization strategies are used in the mechanical optimization. The splittered transonic fan blades mass is reduced by 2.6% while constraining the maximum

  16. Conceptual Design of S-CO{sub 2} Brayton Cycle Radial Turbomachinery for KAIST Micro Modular Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Seongkuk; Kim, Seong Gu; Lee, Jekyoung; Lee, Jeong Ik [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    KAIST proposed a new SMR design, which utilizes S-CO{sub 2} as the working fluid. It was named as KAIST MMR. Compared with existing SMR concepts, KAIST MMR has advantages of achieving smaller volume of power conversion unit (PCU) and containing the core and PCU in one vessel for the complete modularization. Authors noticed that the compressor and turbine assumed performances of KAIST MMR were conservatively selected previously. Thus, this paper tries to address the best estimate values of each turbomachinery in 10MWe class KAIST MMR. The turbomachinery size of the S-CO{sub 2} cycle is smaller than helium Brayton cycle and steam Rankine cycle. The suggested SMR concept adopts passive cooling system by using air. This method can cool reactor without external electricity supply. Small size and more flexible installation in the inland area will be necessary characteristics for the future nuclear application in the water limited region. KAIST MMR meets all these requirements by utilizing S-CO{sub 2} as a working fluid. This paper presents the work for further increasing the system performance by estimating the component efficiency more realistically. The cycle layout adopted for the application is S-CO{sub 2} recuperated Brayton cycle. The best efficiency of compressor and turbine was evaluated to be 84.94% and 90.94%, respectively. By using KAIST in-house code, thermal efficiency and net output were increased to 35.81% and 12.45MWe, respectively, for the same core thermal power. More refined cycle layout and suitable turbomachinery design will be performed in the near future.

  17. Turbomachinery Flow Physics and Dynamic Performance

    CERN Document Server

    Schobeiri, Meinhard T

    2012-01-01

    With this second revised and extended edition, the readers have a solid source of information for designing state-of-the art turbomachinery components and systems at hand.   Based on fundamental principles of turbomachinery thermo-fluid mechanics, numerous CFD based calculation methods are being developed to simulate the complex 3-dimensional, highly unsteady turbulent flow within turbine or compressor stages. The objective of this book is to present the fundamental principles of turbomachinery fluid-thermodynamic design process of turbine and compressor components, power generation and aircraft gas turbines in a unified and compact manner. The book provides senior undergraduate students, graduate students and engineers in the turbomachinery industry with a solid background of turbomachinery flow physics and performance fundamentals that are essential for understanding turbomachinery performance and flow complexes.   While maintaining the unifying character of the book structure in this second revised and e...

  18. Turbomachinery; Turbomaquinaria

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, Elena [ed.] [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    The fossil fuel power stations have a large number of rotary equipment that faces diverse problems that do necessary to improve the present practices of operation and maintenance. In this article are presented the main systems that the Instituto de Investigaciones Electricas (IIE) offers nowadays for the predictive maintenance of rotary equipment in fossil fuel power plants developed by the Management of Turbomachinery. The systems that are described are: the Portable one, the SICAD (Computerized System for Dynamic Analysis), the SMC (Continuous Monitoring System) and finally the SIMPER (Computer Information System for the Predictive Maintenance of Rotary Equipment) [Spanish] Las centrales termoelectricas cuentan con una gran cantidad de equipo rotatorio que enfrenta diversos problemas que hacen necesario mejorar las practicas actuales de operacion y mantenimiento. En este articulo se presentan los principales sistemas que ofrece actualmente el Instituto de Investigaciones Electricas (IIE) para el mantenimiento predictivo de equipos rotatorios en centrales termoelectricas desarrollados en la Gerencia de Turbomaquinaria. Los sistemas que se describen son; el Portil, el Sicad ( Sistema Computarizado para Analisis Dinamico), el SMC ( Sistema de Monitoreo Continuo) y por ultimo el SIMPER (Sistema Informatico para el mantenimiento Predictivo de Equipo Rotatorio)

  19. Balance of Plant System Analysis and Component Design of Turbo-Machinery for High Temperature Gas Reactor Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ballinger, Ronald G. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Wang, Chun Yun [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Kadak, Andrew [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Todreas, Neil [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Mirick, Bradley [Concepts, Northern Engineering and Research, Woburn, MA (United States); Demetri, Eli [Concepts, Northern Engineering and Research, Woburn, MA (United States); Koronowski, Martin [Concepts, Northern Engineering and Research, Woburn, MA (United States)

    2004-08-30

    The Modular Pebble Bed Reactor system (MPBR) requires a gas turbine cycle (Brayton cycle) as the power conversion system for it to achieve economic competitiveness as a Generation IV nuclear system. The availability of controllable helium turbomachinery and compact heat exchangers are thus the critical enabling technology for the gas turbine cycle. The development of an initial reference design for an indirect helium cycle has been accomplished with the overriding constraint that this design could be built with existing technology and complies with all current codes and standards. Using the initial reference design, limiting features were identified. Finally, an optimized reference design was developed by identifying key advances in the technology that could reasonably be expected to be achieved with limited R&D. This final reference design is an indirect, intercooled and recuperated cycle consisting of a three-shaft arrangement for the turbomachinery system. A critical part of the design process involved the interaction between individual component design and overall plant performance. The helium cycle overall efficiency is significantly influenced by performance of individual components. Changes in the design of one component, a turbine for example, often required changes in other components. To allow for the optimization of the overall design with these interdependencies, a detailed steady state and transient control model was developed. The use of the steady state and transient models as a part of an iterative design process represents a key contribution of this work. A dynamic model, MPBRSim, has been developed. The model integrates the reactor core and the power conversion system simultaneously. Physical parameters such as the heat exchangers; weights and practical performance maps such as the turbine characteristics and compressor characteristics are incorporated into the model. The individual component models as well as the fully integrated model of the

  20. Balance of Plant System Analysis and Component Design of Turbo-Machinery for High Temperature Gas Reactor Systems

    International Nuclear Information System (INIS)

    Ballinger, Ronald G.; Chunyun Wang; Kadak, Andrew; Todreas, Neil

    2004-01-01

    The Modular Pebble Bed Reactor system (MPBR) requires a gas turbine cycle (Brayton cycle) as the power conversion system for it to achieve economic competitiveness as a Generation IV nuclear system. The availability of controllable helium turbomachinery and compact heat exchangers are thus the critical enabling technology for the gas turbine cycle. The development of an initial reference design for an indirect helium cycle has been accomplished with the overriding constraint that this design could be built with existing technology and complies with all current codes and standards. Using the initial reference design, limiting features were identified. Finally, an optimized reference design was developed by identifying key advances in the technology that could reasonably be expected to be achieved with limited R and D. This final reference design is an indirect, intercooled and recuperated cycle consisting of a three-shaft arrangement for the turbomachinery system. A critical part of the design process involved the interaction between individual component design and overall plant performance. The helium cycle overall efficiency is significantly influenced by performance of individual components. Changes in the design of one component, a turbine for example, often required changes in other components. To allow for the optimization of the overall design with these interdependencies, a detailed steady state and transient control model was developed. The use of the steady state and transient models as a part of an iterative design process represents a key contribution of this work. A dynamic model, MPBRSim, has been developed. The model integrates the reactor core and the power conversion system simultaneously. Physical parameters such as the heat exchangers; weights and practical performance maps such as the turbine characteristics and compressor characteristics are incorporated into the model. The individual component models as well as the fully integrated model of the

  1. Design of a high-performance centrifugal compressor with new surge margin improvement technique for high speed turbomachinery

    Directory of Open Access Journals (Sweden)

    Sagar Pakle

    2018-03-01

    Full Text Available This paper presents the design of a centrifugal compressor for high-speed turbomachinery. The main focus of the research is to develop a centrifugal compressor with improved aerodynamic performance. As a meridional frame has a significant effect on overall performance of the compressor, special attention has been paid to the end wall contours. The shroud profile is design with bezier curve and hub profile with circular arc contour. The blade angle distribution has been arranged in a manner that it merges with single value at impeller exit. The rake angle is positive at leading edge and negative at trailing edge with identical magnitude. Furthermore, three-dimensional straight line element approach has been used for this design for better manufacturability. The verification of the aerodynamic performance has been carried out using CFD software with consideration of a single blade passage and vaneless diffuser. The result has been compared with matching size aftermarket compressor stage gas stand data. The compressor stage with Trim 55 provides 34% increase in choke flow at 210000 RPM as compared to gas stand data with 87% peak stage efficiency at 110000 RPM. In addition, new surge margin improvement technique has been proposed by means of diffuser enhancement. This technique provides an average of 16% improvement in surge margin compared to standard diffuser stage with 55 trim compressor impeller. The mechanical integrity has been validated at maximum RPM with the aluminum alloy 2014-T6 as a fabrication material. Keywords: Centrifugal compressor, Aerodynamic performance, Surge margin, Blade angles, Stress analysis, Computational fluid dynamics

  2. Turbomachinery Design Using CFD (La Conception des Turbomachines par l’Aerodynamique Numerique).

    Science.gov (United States)

    1994-05-01

    of Heat and Mass Transfer, vol. 15, pp 301-314, 1972. KARADIMAS , G. : Application of Computational Systems to aircraft components development. 9th...ISOABE, Athens, 1989. KARADIMAS , G. : Design of High-Performance Fans Using Advanced Aerodynamic Codes, ASME Paper 88-GT- 141. Amsterdam, 1988. LERAT, A

  3. Improved modeling techniques for turbomachinery flow fields

    Energy Technology Data Exchange (ETDEWEB)

    Lakshminarayana, B. [Pennsylvania State Univ., University Park, PA (United States); Fagan, J.R. Jr. [Allison Engine Company, Indianapolis, IN (United States)

    1995-10-01

    This program has the objective of developing an improved methodology for modeling turbomachinery flow fields, including the prediction of losses and efficiency. Specifically, the program addresses the treatment of the mixing stress tensor terms attributed to deterministic flow field mechanisms required in steady-state Computational Fluid Dynamic (CFD) models for turbo-machinery flow fields. These mixing stress tensors arise due to spatial and temporal fluctuations (in an absolute frame of reference) caused by rotor-stator interaction due to various blade rows and by blade-to-blade variation of flow properties. These tasks include the acquisition of previously unavailable experimental data in a high-speed turbomachinery environment, the use of advanced techniques to analyze the data, and the development of a methodology to treat the deterministic component of the mixing stress tensor. Penn State will lead the effort to make direct measurements of the momentum and thermal mixing stress tensors in high-speed multistage compressor flow field in the turbomachinery laboratory at Penn State. They will also process the data by both conventional and conditional spectrum analysis to derive momentum and thermal mixing stress tensors due to blade-to-blade periodic and aperiodic components, revolution periodic and aperiodic components arising from various blade rows and non-deterministic (which includes random components) correlations. The modeling results from this program will be publicly available and generally applicable to steady-state Navier-Stokes solvers used for turbomachinery component (compressor or turbine) flow field predictions. These models will lead to improved methodology, including loss and efficiency prediction, for the design of high-efficiency turbomachinery and drastically reduce the time required for the design and development cycle of turbomachinery.

  4. Design and Calibration of a Full Scale Active Magnetic Bearing Based Test Facility for Investigating Rotordynamic Properties of Turbomachinery Seals in Multiphase Flow

    DEFF Research Database (Denmark)

    Voigt, Andreas Jauernik; Mandrup-Poulsen, Christian; Nielsen, Kenny Krogh

    2016-01-01

    of the subsea installed rotating machinery. It is well known that careful design of turbomachinery seals, such as interstage and balance piston seals, is pivotal for the performance of pumps and compressors. Consequently, the ability to predict the complex interaction between fluid dynamics and rotordynamics...... University of Denmark and Lloyd's Register Consulting are currently establishing a purpose built state of the art multiphase seal test facility, which is divided into three modules. Module I consists of a full scale Active Magnetic Bearing (AMB) based rotor dynamic test bench. The internally designed custom...... AMBs are equipped with an embedded Hall sensor system enabling high precision non-contact seal force quantification. Module II is a fully automatised calibration facility for the Hall sensor based force quantification system. Module III consists of the test seal housing assembly. This paper provides...

  5. Turbomachinery systems for floating production applications

    Energy Technology Data Exchange (ETDEWEB)

    Windt, Jonathan P.; Kurz, Rainer [Solar Turbines Incorporated, San Diego, CA (United States)

    2008-07-01

    Since 1995 there has been a dramatic increase in oil and gas exploration and production using floating platforms in deeper waters located further offshore. This exploration started with tension leg platforms, progressed through SPARs and Semi-Submersibles, and later evolved into Floating Production Storage and Offloading (FPSO) vessels. Turbomachinery equipment installed on a floating platform or vessel will be expected to operate in the same manner as a land based machine, but in a variety of climate and environmental conditions that now includes motion. To operate successfully, specific design considerations for the turbo-machinery packages are required. It is critical to take into account the type of vessel, the expected list, trim and dynamic motion angles, the dynamic forces applied, the expected deck deflection as a result of those forces, understand the applicable class requirement, and where the equipment will be located on the vessel. This information is then translated into the design conditions to determine the type of mounting method to be used to attach the turbo-machinery package to the deck, the expected accelerations for structural analysis, and oil tank and system designs for fluid management. Furthermore, compressor designs need to allow utmost flexibility to adapt to changing operating conditions. (author)

  6. Aerodynamical calculation of turbomachinery bladings

    International Nuclear Information System (INIS)

    Fruehauf, H.H.

    1978-01-01

    Various flow models are presented in comparison to one another, these flow models being obtained from the basic equations of turbomachinery aerodynamics by means of a series of simplifying assumptions on the spatial distribution of the flow quantities. The simplifying assumptions are analysed precisely. With their knowledge it is possible to construct more accurate simplified flow models, which are necessary for the efficient aerodynamical development of highperformance turbomachinery bladings by means of numerical methods. (orig.) 891 HP [de

  7. Turbomachinery: latest developments in a changing scene

    International Nuclear Information System (INIS)

    1991-01-01

    The contributions to the 1991 European Conference on the latest developments in turbomachinery are presented. The topics covered include: computational fluid dynamics methods applied to the aerodynamics of turbine blades; developments associated with steam turbines and gas turbines; flow patterns for turbine blades; compressor design and development; turbine test facilities; film cooling; heat transfer; theoretical treatment of transonic and unsteady flow; condensation phenomena and wet steam flow; water extraction from steam turbine blades; wetness losses in steam turbines in nuclear power plants and pressure loss reduction; aerodynamic instabilities arising from governing valves in Pressurized Water Reactor steam turbines. (UK)

  8. TIGER: A graphically interactive grid system for turbomachinery applications

    Science.gov (United States)

    Shih, Ming-Hsin; Soni, Bharat K.

    1992-01-01

    Numerical grid generation algorithm associated with the flow field about turbomachinery geometries is presented. Graphical user interface is developed with FORMS Library to create an interactive, user-friendly working environment. This customized algorithm reduces the man-hours required to generate a grid associated with turbomachinery geometry, as compared to the use of general-purpose grid generation softwares. Bezier curves are utilized both interactively and automatically to accomplish grid line smoothness and orthogonality. Graphical User Interactions are provided in the algorithm, allowing the user to design and manipulate the grid lines with a mouse.

  9. Planning for design quality

    International Nuclear Information System (INIS)

    Marguglio, B.W.

    1977-01-01

    In the nuclear industry and in other high technology industries in which the Government serves as either a customer or a regulator, it is almost always required that the contractor prepare a Quality Program Plan sometimes also referred to as a Quality Program Index. Often, the Quality Program Plan is included as part of the contractor's proposal in response to the Government's or a prime contractor's Request for Proposal. At this stage, the Quality Program Plan serves to demonstrate to the prospective customer the availability of the various quality systems. It provides the customer with a commitment as to the use of these quality systems, thus giving greater assurance that the customer's overall quality and design requirements can be met. The Quality Program Plan is contributing to the salability of the proposal. 1 ref

  10. IMPROVING CONCEPTUAL DESIGN QUALITY

    DEFF Research Database (Denmark)

    Bush, Stuart; Robotham, Antony John

    1999-01-01

    designer to identify clear targets for design improvement and to measure the effectiveness of any new solution, whilst attention to QFD ensures customer requirements are still being satisfied.Often, SME's are not aware of many of the best design practices and so are not able to meet the demand......This paper will consider how Quality Function Deployment (QFD) and Design for Manufacture and Assembly (DFMA) processes can be used to improve the design quality of products at the concept stage. We appreciate that both QFD and DFMA are techniques that have been used for some time by mature product...... quality is maintained in design project work. The projects described have been carried out with products manufactured by small to medium sized enterprises (SME's), where we have found significant opportunities for product improvement. The quantitative nature of DFMA analysis results allows the novice...

  11. Quality audit in design

    International Nuclear Information System (INIS)

    Horton, G.T.

    1976-01-01

    The subject is discussed under the headings: introduction (explanation of firm's responsibility to design and procure naval nuclear reactor plant for the Ministry of Defence, whose quality assurance requirements are laid down in Defence Standards); principles of quality audit; audit procedure. (U.K.)

  12. ALS turbomachinery technology

    Science.gov (United States)

    Csomor, A.; Faulkner, C.; Ferlita, F.

    1990-01-01

    Advanced Development Programs are being pursued by Rocketdyne, Aerojet, and Pratt and Whitney to define and validate design approaches toward producing low-cost, reliable liquid-hydrogen and liquid-oxygen turbopumps for a 2580 kN (580 klb) thrust Advanced Launch System. The generic approach, which is evolving after 18 months of trade studies and conceptual and preliminary design efforts, is explained. In addition, the preliminary liquid-hydrogen turbopump designs produced in parallel tasks by Rocketdyne and Aerojet and the liquid-oxygen turbopump design produced by Pratt and Whitney are described, and technology features and issues are discussed.

  13. Contributions to some cavitation problems in turbomachinery

    OpenAIRE

    Arakeri, VH

    1999-01-01

    In the present article, three problems associated with cavitation in turbomachinery are discussed. The first one deals with the potential application of recent understanding in cavitation inception to similar problems in turbomachinery. The second considers the thermodynamic effects in developed cavitation. This has relevance to turbopump operation using fluids other than water. Old correlations to predict the above effect are summarized and a new correlation is proposed. Lastly, the possible...

  14. PRACTITIONERS OF DESIGN FOR QUALITY

    DEFF Research Database (Denmark)

    Robotham, Antony John

    1999-01-01

    designers must have more physical contact with engineering products, learn about product quality and how it is achieved, and develop a quality mind-set. They should be challenged to create novel and innovative solutions. Industrial designers require a formal awareness and knowledge of performance qualities...... the design research community needs to face.The paper argues that Design for Quality provides a robust framework, which can be used by the industrial, research, and educational communities as a platform for improving the skills and capability of the practitioners of Design for Quality.If engineering...... and the DFQ framework.Design Research needs to provide deeper insight in to the soft aspects of quality and DFQ, e.g. understanding the quality mind-set and how it is developed, understanding the perception of quality and its relationships to the product characteristics, and what mix of skills and knowledge...

  15. Quality Attribute Design Primitives

    National Research Council Canada - National Science Library

    Bass, Len

    2000-01-01

    This report focuses on the quality attribute aspects of mechanisms. An architectural mechanism is a 'structure whereby objects collaborate to provide some behavior that satisfies a requirement of the problem...

  16. Fluid mechanics and thermodynamics of turbomachinery

    CERN Document Server

    Dixon, S Larry

    2005-01-01

    The new edition will continue to be of use to engineers in industry and technological establishments, especially as brief reviews are included on many important aspects of Turbomachinery, giving pointers towards more advanced sources of information. For readers looking towards the wider reaches of the subject area, very useful additional reading is referenced in the bibliography. The subject of Turbomachinery is in continual review, and while the basics do not change, research can lead to refinements in popular methods, and new data can emerge. This book has applications for professiona

  17. Meanline Analysis of Turbines with Choked Flow in the Object-Oriented Turbomachinery Analysis Code

    Science.gov (United States)

    Hendricks, Eric S.

    2016-01-01

    The prediction of turbomachinery performance characteristics is an important part of the conceptual aircraft engine design process. During this phase, the designer must examine the effects of a large number of turbomachinery design parameters to determine their impact on overall engine performance and weight. The lack of detailed design information available in this phase necessitates the use of simpler meanline and streamline methods to determine the turbomachinery geometry characteristics and provide performance estimates prior to more detailed CFD (Computational Fluid Dynamics) analyses. While a number of analysis codes have been developed for this purpose, most are written in outdated software languages and may be difficult or impossible to apply to new, unconventional designs. The Object-Oriented Turbomachinery Analysis Code (OTAC) is currently being developed at NASA Glenn Research Center to provide a flexible meanline and streamline analysis capability in a modern object-oriented language. During the development and validation of OTAC, a limitation was identified in the code's ability to analyze and converge turbines as the flow approached choking. This paper describes a series of changes which can be made to typical OTAC turbine meanline models to enable the assessment of choked flow up to limit load conditions. Results produced with this revised model setup are provided in the form of turbine performance maps and are compared to published maps.

  18. Four-Spot Time-Of-Flight Laser Anemometer For Turbomachinery

    Science.gov (United States)

    Wernet, Mark P.; Skoch, Gary J.

    1995-01-01

    Two-color, four-spot time-of-flight laser anemometer designed for measuring flow velocity within narrow confines of small centrifugal compressor. Apparatus well suited for measuring fast (typical speeds 160 to 700 m/s), highly turbulent gas flows in turbomachinery. Other potential applications include measurement of gas flows in pipelines and in flows from explosions.

  19. Design and Calibration of a Full-Scale Active Magnetic Bearing-Based Test Facility for Investigating Rotordynamic Properties of Turbomachinery Seals in Multiphase Flow

    DEFF Research Database (Denmark)

    Voigt, Andreas Jauernik; Mandrup-Poulsen, Christian; Nielsen, Kenny

    2017-01-01

    The recent move towards subsea oil and gas production brings about a requirement to locate process equipment in deepwater installations. Furthermore, there is a drive towards omitting well stream separation functionality, as this adds complexity and cost to the subsea installation. This in turn...... leads to technical challenges for the subsea installed pumps and compressors that are now required to handle multiphase flow of varying gas to liquid ratios. This highlights the necessity for a strong research focus on multiphase flow impact on rotordynamic properties and thereby operational stability...... University of Denmark and Lloyd's Register Consulting are currently establishing a purpose built state of the art multiphase seal test facility. This paper provides details on the design of the novel test facility and the calibration of the Hall sensor system employed to measure AMB forces. Calibration...

  20. Simple, stable and reliable modeling of gas properties of organic working fluids in aerodynamic designs of turbomachinery for ORC and VCC

    Science.gov (United States)

    Kawakubo, T.

    2016-05-01

    A simple, stable and reliable modeling of the real gas nature of the working fluid is required for the aerodesigns of the turbine in the Organic Rankine Cycle and of the compressor in the Vapor Compression Cycle. Although many modern Computational Fluid Dynamics tools are capable of incorporating real gas models, simulations with such a gas model tend to be more time-consuming than those with a perfect gas model and even can be unstable due to the simulation near the saturation boundary. Thus a perfect gas approximation is still an attractive option to stably and swiftly conduct a design simulation. In this paper, an effective method of the CFD simulation with a perfect gas approximation is discussed. A method of representing the performance of the centrifugal compressor or the radial-inflow turbine by means of each set of non-dimensional performance parameters and translating the fictitious perfect gas result to the actual real gas performance is presented.

  1. General approach to quality in design

    International Nuclear Information System (INIS)

    Osborne, W.J.

    1981-01-01

    Design engineers, either consciously or unconsciously, use quality work elements to achieve quality in design. these quality work elements are identified, classified as basic or optional, and explained. The rationale for applying them to the design of fusion devices is presented in terms of effects on performance and costs. Relevant quality terms are defined, and elements of the design quality system are described. Quality of design is the direct responsibility of the design engineer

  2. Identification of Turbomachinery Noise Sources Using Acoustical Holography, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Evaluation and enhancement of the acoustical performance of turbomachinery requires knowledge of the acoustic sources. However, the noise generation mechanisms...

  3. Reduced Order Modeling Methods for Turbomachinery Design

    Science.gov (United States)

    2009-03-01

    and Ma- terials Conference, May 2006. [45] A. Gelman , J. B. Carlin, H. S. Stern, and D. B. Rubin, Bayesian Data Analysis. New York, NY: Chapman I& Hall...Macian- Juan , and R. Chawla, “A statistical methodology for quantif ca- tion of uncertainty in best estimate code physical models,” Annals of Nuclear En

  4. Experience with small turbomachinery in a 400 watt refrigerator

    International Nuclear Information System (INIS)

    Fuerst, J.D.

    1996-09-01

    A refrigerator similar to one of the Fermilab Tevatron satellites was reconfigured to use turbomachinery instead of the reciprocating equipment typical of the installations. A Sulzer dry turboexpander, Creare wet turboexpander, and IHI centrifugal cold compressor have been installed and operated for about 8000 hours. Experience was gained both with the rotating machinery and with the refrigerator itself as it interfaced with the load. Equipment was set up to regulate in the same manner as the reciprocating devices had. Heat load and operating mode were adjusted and evaluations made regarding the behavior of the devices. Individual equipment performance is described as well as system behavior and overall integration of the machinery. In particular, attention is paid to the Creare wet turboexpander. This device is operated for the first time as part of a full scale refrigeration system, testing not only its performance at the design point but also its off design characteristics and behavior in transient situations

  5. Experience with small turbomachinery in a 400 watt refrigerator

    International Nuclear Information System (INIS)

    Fuerst, J.D.

    1996-01-01

    A refrigerator similar to one of the Fermilab Tevatron satellites was re-configured to use turbomachinery instead of the reciprocating equipment typical of the installations. A Sulzer dry turboexpander, Creare wet turboexpander, and IHI centrifugal cold compressor have been installed and operated for about 8000 hours. Experience was gained both with the rotating machinery and with the refrigerator itself as it interfaced with the load. Equipment was set up to regulate in the same manner as the reciprocating devices had. Heat loads and operating mode were adjusted and evaluations made regarding the behavior of the devices. Individual equipment performance is described, as well as system behavior and overall integration of the machinery. In particular, attention is paid to the Creare wet turboexpander. This device is operated for the first time as part of a full scale refrigeration system, testing not only its performance at the design point but also its off design characteristics and behavior in transient situations

  6. Particle trajectories in full 3D flow field of turbomachinery

    International Nuclear Information System (INIS)

    Ling, Z.G.; Huang, S.L.

    1986-01-01

    Particle trajectory prediction is important for particulate laden flow turbomachinery as it helps to understand the cause of erosion phenomena and to improve the design of blade passages. In this paper, on the basis of previous works, particle trajectories in turbine stages are predicted in connection with full 3D gas flow field solved by time marching method. The secondary flow effect is also partially considered by assuming a total pressure distribution at the inlet of the moving blade row. The results show that passage vortex due to secondary flow will cause upward and downward divergence of particle trajectories at the rear part of near blade pressure surface which is evidenced by the real appearance of eroded trace on turbine blade after long period of operation

  7. Wake Management Strategies for Reduction of Turbomachinery Fan Noise

    Science.gov (United States)

    Waitz, Ian A.

    1998-01-01

    The primary objective of our work was to evaluate and test several wake management schemes for the reduction of turbomachinery fan noise. Throughout the course of this work we relied on several tools. These include 1) Two-dimensional steady boundary-layer and wake analyses using MISES (a thin-shear layer Navier-Stokes code), 2) Two-dimensional unsteady wake-stator interaction simulations using UNSFLO, 3) Three-dimensional, steady Navier-Stokes rotor simulations using NEWT, 4) Internal blade passage design using quasi-one-dimensional passage flow models developed at MIT, 5) Acoustic modeling using LINSUB, 6) Acoustic modeling using VO72, 7) Experiments in a low-speed cascade wind-tunnel, and 8) ADP fan rig tests in the MIT Blowdown Compressor.

  8. Vibration Energy Harvesting Potential for Turbomachinery Applications

    Directory of Open Access Journals (Sweden)

    Adrian STOICESCU

    2018-03-01

    Full Text Available The vibration energy harvesting process represents one of the research directions for increasing power efficiency of electric systems, increasing instrumentation nodes autonomy in hard to reach locations and decreasing total system mass by eliminating cables and higher-power adapters. Research based on the possibility of converting vibration energy into useful electric energy is used to evaluate the potential of its use on turbomachinery applications. Aspects such as the structure and characteristics of piezoelectric generators, harvesting networks, their setup and optimization, are considered. Finally, performance test results are shown using piezoelectric systems on a turbine engine.

  9. Determination of averaged axisymmetric flow surfaces according to results obtained by numerical simulation of flow in turbomachinery

    Directory of Open Access Journals (Sweden)

    Bogdanović-Jovanović Jasmina B.

    2012-01-01

    Full Text Available In the increasing need for energy saving worldwide, the designing process of turbomachinery, as an essential part of thermal and hydroenergy systems, goes in the direction of enlarging efficiency. Therefore, the optimization of turbomachinery designing strongly affects the energy efficiency of the entire system. In the designing process of turbomachinery blade profiling, the model of axisymmetric fluid flows is commonly used in technical practice, even though this model suits only the profile cascades with infinite number of infinitely thin blades. The actual flow in turbomachinery profile cascades is not axisymmetric, and it can be fictively derived into the axisymmetric flow by averaging flow parameters in the blade passages according to the circular coordinate. Using numerical simulations of flow in turbomachinery runners, its operating parameters can be preliminarily determined. Furthermore, using the numerically obtained flow parameters in the blade passages, averaged axisymmetric flow surfaces in blade profile cascades can also be determined. The method of determination of averaged flow parameters and averaged meridian streamlines is presented in this paper, using the integral continuity equation for averaged flow parameters. With thus obtained results, every designer can be able to compare the obtained averaged flow surfaces with axisymmetric flow surfaces, as well as the specific work of elementary stages, which are used in the procedure of blade designing. Numerical simulations of flow in an exemplary axial flow pump, used as a part of the thermal power plant cooling system, were performed using Ansys CFX. [Projekat Ministarstva nauke Republike Srbije, br. TR33040: Revitalization of existing and designing new micro and mini hydropower plants (from 100 kW to 1000 kW in the territory of South and Southeast Serbia

  10. Dynamics of face seals for high speed turbomachinery

    Science.gov (United States)

    Leefe, Simon

    1993-10-01

    Face seals in rocket engine fuel and oxidizer turbopumps have been the subject of intense investigation for over 25 years. While advances have been made in the understanding of thin film lubrication between seal faces, valuable data has been produced on the friction and wear of material pairs in cryogenic environments; pioneering work has been done on the effect of lubricant phase change in seals, and many improvements have been made in mechanical seal design. Relatively superficial attention has been given to the vibrational dynamics of face seals in high-speed turbomachinery. BHR Group Ltd. (formerly BHRA) has recently completed the first stage of a study, commissioned by the European Space Agency, to investigate this area. This has involved the development of a two-dimensional adiabatic, turbulent lubrication model for thick gas film applications, the production of an integrated mathematical model of gas seal vibrational dynamics for thin film applications, implementation in software, the undertaking of an experimental program to validate software against variations in operating conditions and design variables, and suggestions for improved seal design.

  11. Design quality assurance for nuclear power plants

    International Nuclear Information System (INIS)

    1986-07-01

    This Standard contains the requirements for the quality assurance program applicable to the design phase of a nuclear plant, and is applicable to the design of safety-related equipment, systems, and structures, as identified by the owner. 1 fig

  12. Design quality assurance for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-07-01

    This Standard contains the requirements for the quality assurance program applicable to the design phase of a nuclear plant, and is applicable to the design of safety-related equipment, systems, and structures, as identified by the owner. 1 fig.

  13. Quality planning for major plant design modifications

    International Nuclear Information System (INIS)

    Dulee, R.J.

    1988-01-01

    This paper reviews the approach and activities undertaken by Public Service Electric and Gas Company's (PSE and G's) nuclear quality assurance (QA) department to support major plant design modifications conducted during refueling outages at Salem Generating Station. It includes the planning and implementation of quality plans developed to provide both QA and quality control (QC) coverage of modification performed by contracted service organizations

  14. Quality assurance in the design

    International Nuclear Information System (INIS)

    Edelmann, J.

    1980-01-01

    System- and product-related quality assurance measures are completing one another. Certainly it is possible to detect a lot of defects in the single technical document by well controlled product related quality inspections and to avoid the consequences of these defects; but also a not unimportant part of defects and deviations has its origin in system linked deficiencies. The latter can be detected more easily and more securely by means of system related reviews (System audit, Product audit). But also the sole implementation of system related quality assurance measures keeps the danger to get stuck only in formality and to loose all references to the specific characteristics of the product. (orig./RW)

  15. Design optimization for cost and quality: The robust design approach

    Science.gov (United States)

    Unal, Resit

    1990-01-01

    Designing reliable, low cost, and operable space systems has become the key to future space operations. Designing high quality space systems at low cost is an economic and technological challenge to the designer. A systematic and efficient way to meet this challenge is a new method of design optimization for performance, quality, and cost, called Robust Design. Robust Design is an approach for design optimization. It consists of: making system performance insensitive to material and subsystem variation, thus allowing the use of less costly materials and components; making designs less sensitive to the variations in the operating environment, thus improving reliability and reducing operating costs; and using a new structured development process so that engineering time is used most productively. The objective in Robust Design is to select the best combination of controllable design parameters so that the system is most robust to uncontrollable noise factors. The robust design methodology uses a mathematical tool called an orthogonal array, from design of experiments theory, to study a large number of decision variables with a significantly small number of experiments. Robust design also uses a statistical measure of performance, called a signal-to-noise ratio, from electrical control theory, to evaluate the level of performance and the effect of noise factors. The purpose is to investigate the Robust Design methodology for improving quality and cost, demonstrate its application by the use of an example, and suggest its use as an integral part of space system design process.

  16. DESIGN QUALITY IN MECHANICAL ENGINEERING APPLICATION

    Directory of Open Access Journals (Sweden)

    Ayşegül Akdogan Eker

    2010-09-01

    Full Text Available There is a close relationship between material chose and quality in mechanical engineering application like there is in all the other engineering applications. If this relation is balanced then engineering success increases. Material chose comes to fore in the design process most of the time. The two most important responsibilities of the design engineer in here is to chose suitable material and to know the production processes about design. The chose of material of a design that will fulfill the needs all through its life has great importance. It is needed to limit the material applicants by choosing the most suitable ones among variable material. Choosing materials that were examined before and whose behavior is well known provides the designer to feel confident. However since using highly successful materials would increase the competitive power of the designs; designers should follow the developments in materials and know the features of new materials. The description of these features can be interpreted within quality. Quality from the point of engineer is the total fulfillment of expectations.Engineer today are faced with very important problems such as fast technological innovations, a dynamic socio-economical environment, global rivalry. One of the life buoys they stick while trying to solve these problems is total method of quality control. Total Quality model which can provide higher competitive power compared to classical management model brings success only when applied with its whole components. "Approach toward prevention" and "measurement and statistics" have an important place among these elements. The first step of the approach toward prevention composes of design quality and Quality Function Deployment (QFD, or in other words The House of Quality method that will provide this. In this paper; considering the quality function deployment, how the chose of material are done in mechanical engineering applications will be explained.

  17. 10 conference and Latin American turbomachinery exhibition; 10 congreso y exposicion latinoamericana de turbomaquinaria

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-11-15

    This conference was done to promote the exchange of experiences among specialists, users, manufactures and research institutions in the field of the turbomachinery. To spread the last researches and developments focus to the design and maintenance of steam, gas and hydraulic turbines, axial compressors and centrifugal pumps, fans, electric motors, auxiliary equipment and cogeneration. [Spanish] Este congreso se realizo con el fin de promover el intercambio de experiencias entre especialistas, usuarios, fabricantes e institutos de investigacion en el campo de la turbomaquinaria. Divulgar las ultimas investigaciones y desarrollos enfocados al diseno y mantenimiento de turbinas de vapor, de gas e hidraulicas, compresores axiales y centrifugos, bombas, ventiladores, motores electricos, equipos auxiliares y cogeneracion.

  18. Bearing compartment seal systems for turbomachinery in direct-cycle HTGR power plants

    International Nuclear Information System (INIS)

    Adams, R.G.; Boenig, F.H.; Pfeifer, G.D.

    1977-10-01

    The direct-cycle High-Temperature Gas-Cooled Reactor (HTGR) employs a closed gas-turbine cycle with the primary reactor coolant (helium) as the working fluid. Design studies on this type of plant, carried out since 1971, have demonstrated, among other points, the advantages of the integrated arrangement, in which power from the cycle is transmitted to the electric generators by turbomachines completely enclosed in the reactor pressure vessel. A result of this arrangement is that the bearings are entirely enclosed within the primary coolant system of the reactor. An important aspect of the design of the turbomachinery is its prevention or minimization of the ingress of lubricants into the primary coolant system and its prevention of ingress of primary coolant into the bearing compartments. The design studies, which included thorough conceptual designs of the turbomachinery with emphasis on bearings and seals and their support systems showed that total exclusion of lubricant requires extremely complex seals and seal support systems. The variation of system low-end pressure with control actuation and the requirement that the bearing cavity pressure follow these variations were proved to further complicate the service system. The tolerance of even relatively minute amounts of entering lubricant during control transients will allow considerable simplification. This paper discusses the above-mentioned problems and their solutions in tracing the design evolution of a satisfactory bearing-compartment seals and service system. The resulting system appears to be feasible on the basis of experience with industrial gas turbines

  19. Oil-free bearing development for high-speed turbomachinery in distributed energy systems – dynamic and environmental evaluation

    Directory of Open Access Journals (Sweden)

    Tkacz Eliza

    2015-09-01

    Full Text Available Modern distributed energy systems, which are used to provide an alternative to or an enhancement of traditional electric power systems, require small size highspeed rotor turbomachinery to be developed. The existing conventional oil-lubricated bearings reveal performance limits at high revolutions as far as stability and power loss of the bearing are concerned. Non-conventional, oil-free bearings lubricated with the machine working medium could be a remedy to this issue. This approach includes a correct design of the machine flow structure and an accurate selection of the bearing type. Chosen aspects of the theoretical and experimental investigations of oil-free bearings and supports; including magnetic, tilting pad, pressurized aerostatic and hydrostatic bearings as well as some applications of oil-free bearing technology for highspeed turbomachinery; are described in the paper.

  20. Premium quality for a mechanical design department

    OpenAIRE

    Rofín Serrà, Guillem

    2009-01-01

    This Thesis has been carried out in a market which is expected to grow rapidly in the next decade. Because of this, actors in the market like Alpha want to strengthen their business position through refining the quality of their products and processes. One of the internal targets of MD, a mechanical design department within Alpha, referred to “premium product quality parameters” although these were not defined. Hence, this Thesis intends to contribute in the definition and understanding that ...

  1. Quality By Design: Concept To Applications.

    Science.gov (United States)

    Swain, Suryakanta; Padhy, Rabinarayan; Jena, Bikash Ranjan; Babu, Sitty Manohar

    2018-03-08

    Quality by Design is associated to the modern, systematic, scientific and novel approach which is concerned with pre-distinct objectives that not only focus on product, process understanding but also leads to process control. It predominantly signifies the design and product improvement and the manufacturing process in order to fulfill the predefined manufactured goods or final products quality characteristics. It is quite essential to identify desire and required product performance report such as Target Product Profile, typical Quality Target Product Profile (QTPP) and Critical Quality attributes (CQA). This review highlighted about the concepts of QbD design space, for critical material attributes (CMAs) as well as the critical process parameters that can totally affect the CQAs within which the process shall be unaffected and consistently manufacture the required product. Risk assessment tools and design of experiments are its prime components. This paper outlines the basic knowledge of QbD, the key elements; steps as well as various tools for QbD implementation in pharmaceutics field are presented briefly. In addition to this, quite a lot of applications of QbD in numerous pharmaceutical related unit operations are discussed and summarized. This article provides a complete data as well as the road map for universal implementation and application of QbD for pharmaceutical products. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. A variational multiscale method for particle-cloud tracking in turbomachinery flows

    Science.gov (United States)

    Corsini, A.; Rispoli, F.; Sheard, A. G.; Takizawa, K.; Tezduyar, T. E.; Venturini, P.

    2014-11-01

    We present a computational method for simulation of particle-laden flows in turbomachinery. The method is based on a stabilized finite element fluid mechanics formulation and a finite element particle-cloud tracking method. We focus on induced-draft fans used in process industries to extract exhaust gases in the form of a two-phase fluid with a dispersed solid phase. The particle-laden flow causes material wear on the fan blades, degrading their aerodynamic performance, and therefore accurate simulation of the flow would be essential in reliable computational turbomachinery analysis and design. The turbulent-flow nature of the problem is dealt with a Reynolds-Averaged Navier-Stokes model and Streamline-Upwind/Petrov-Galerkin/Pressure-Stabilizing/Petrov-Galerkin stabilization, the particle-cloud trajectories are calculated based on the flow field and closure models for the turbulence-particle interaction, and one-way dependence is assumed between the flow field and particle dynamics. We propose a closure model utilizing the scale separation feature of the variational multiscale method, and compare that to the closure utilizing the eddy viscosity model. We present computations for axial- and centrifugal-fan configurations, and compare the computed data to those obtained from experiments, analytical approaches, and other computational methods.

  3. Materials, Turbomachinery and Heat Exchangers for Supercritical CO2 Systems

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Mark; Nellis, Greg; Corradini, Michael

    2012-10-19

    The objective of this project is to produce the necessary data to evaluate the performance of the supercritical carbon dioxide cycle. The activities include a study of materials compatibility of various alloys at high temperatures, the heat transfer and pressure drop in compact heat exchanger units, and turbomachinery issues, primarily leakage rates through dynamic seals. This experimental work will serve as a test bed for model development and design calculations, and will help define further tests necessary to develop high-efficiency power conversion cycles for use on a variety of reactor designs, including the sodium fast reactor (SFR) and very high-temperature gas reactor (VHTR). The research will be broken into three separate tasks. The first task deals with the analysis of materials related to the high-temperature S-CO{sub 2} Brayton cycle. The most taxing materials issues with regard to the cycle are associated with the high temperatures in the reactor side heat exchanger and in the high-temperature turbine. The system could experience pressures as high as 20MPa and temperatures as high as 650°C. The second task deals with optimization of the heat exchangers required by the S-CO{sub 2} cycle; the S-CO{sub 2} flow passages in these heat exchangers are required whether the cycle is coupled with a VHTR or an SFR. At least three heat exchangers will be required: the pre-cooler before compression, the recuperator, and the heat exchanger that interfaces with the reactor coolant. Each of these heat exchangers is unique and must be optimized separately. The most challenging heat exchanger is likely the pre-cooler, as there is only about a 40°C temperature change but it operates close to the CO{sub 2} critical point, therefore inducing substantial changes in properties. The proposed research will focus on this most challenging component. The third task examines seal leakage through various dynamic seal designs under the conditions expected in the S-CO{sub 2} cycle

  4. Gas temperature measurements in short duration turbomachinery test facilities

    Science.gov (United States)

    Cattafesta, L. N.; Epstein, A. H.

    1988-07-01

    Thermocouple rakes for use in short-duration turbomachinery test facilities have been developed using very fine thermocouples. Geometry variations were parametrically tested and showed that bare quartz junction supports (76 microns in diameter) yielded superior performance, and were rugged enough to survive considerable impact damage. Using very low cost signal conditioning electronics, temperature accuracies of 0.3 percent were realized yielding turbine efficiency measurements at the 1-percent level. Ongoing work to improve this accuracy is described.

  5. Chip Design Process Optimization Based on Design Quality Assessment

    Science.gov (United States)

    Häusler, Stefan; Blaschke, Jana; Sebeke, Christian; Rosenstiel, Wolfgang; Hahn, Axel

    2010-06-01

    Nowadays, the managing of product development projects is increasingly challenging. Especially the IC design of ASICs with both analog and digital components (mixed-signal design) is becoming more and more complex, while the time-to-market window narrows at the same time. Still, high quality standards must be fulfilled. Projects and their status are becoming less transparent due to this complexity. This makes the planning and execution of projects rather difficult. Therefore, there is a need for efficient project control. A main challenge is the objective evaluation of the current development status. Are all requirements successfully verified? Are all intermediate goals achieved? Companies often develop special solutions that are not reusable in other projects. This makes the quality measurement process itself less efficient and produces too much overhead. The method proposed in this paper is a contribution to solve these issues. It is applied at a German design house for analog mixed-signal IC design. This paper presents the results of a case study and introduces an optimized project scheduling on the basis of quality assessment results.

  6. Prediction of Strutural Response and Fluid-Induced Vibration in Turbomachinery, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced turbomachinery components play a critical role in launch vehicle and spacecraft liquid rocket propulsion systems. To achieve desired efficiencies, extremely...

  7. Development of a Robust and Efficient Parallel Solver for Unsteady Turbomachinery Flows

    Science.gov (United States)

    West, Jeff; Wright, Jeffrey; Thakur, Siddharth; Luke, Ed; Grinstead, Nathan

    2012-01-01

    The traditional design and analysis practice for advanced propulsion systems relies heavily on expensive full-scale prototype development and testing. Over the past decade, use of high-fidelity analysis and design tools such as CFD early in the product development cycle has been identified as one way to alleviate testing costs and to develop these devices better, faster and cheaper. In the design of advanced propulsion systems, CFD plays a major role in defining the required performance over the entire flight regime, as well as in testing the sensitivity of the design to the different modes of operation. Increased emphasis is being placed on developing and applying CFD models to simulate the flow field environments and performance of advanced propulsion systems. This necessitates the development of next generation computational tools which can be used effectively and reliably in a design environment. The turbomachinery simulation capability presented here is being developed in a computational tool called Loci-STREAM [1]. It integrates proven numerical methods for generalized grids and state-of-the-art physical models in a novel rule-based programming framework called Loci [2] which allows: (a) seamless integration of multidisciplinary physics in a unified manner, and (b) automatic handling of massively parallel computing. The objective is to be able to routinely simulate problems involving complex geometries requiring large unstructured grids and complex multidisciplinary physics. An immediate application of interest is simulation of unsteady flows in rocket turbopumps, particularly in cryogenic liquid rocket engines. The key components of the overall methodology presented in this paper are the following: (a) high fidelity unsteady simulation capability based on Detached Eddy Simulation (DES) in conjunction with second-order temporal discretization, (b) compliance with Geometric Conservation Law (GCL) in order to maintain conservative property on moving meshes for

  8. Design of a power conversion system for an indirect cycle, helium cooled pebble bed reactor system

    International Nuclear Information System (INIS)

    Wang, C.; Ballinger, R.G.; Stahle, P.W.; Demetri, E.; Koronowski, M.

    2002-01-01

    A design is presented for the turbomachinery for an indirect cycle, closed, helium cooled modular pebble bed reactor system. The design makes use of current technology and will operate with an overall efficiency of 45%. The design uses an intermediate heat exchanger which isolated the reactor cycle from the turbomachinery. This design excludes radioactive fission products from the turbomachinery. This minimizes the probability of an air ingress accident and greatly simplifies maintenance. (author)

  9. Design and implementation air quality monitoring robot

    Science.gov (United States)

    Chen, Yuanhua; Li, Jie; Qi, Chunxue

    2017-01-01

    Robot applied in environmental protection can break through the limitations in working environment, scope and mode of the existing environmental monitoring and pollution abatement equipments, which undertake the innovation and improvement in the basin, atmosphere, emergency and pollution treatment facilities. Actually, the relevant technology is backward with limited research and investment. Though the device companies have achieved some results in the study on the water quality monitoring, pipeline monitoring and sewage disposal, this technological progress on the whole is still much slow, and the mature product has not been formed. As a result, the market urges a demand of a new type of device which is more suitable for environmental protection on the basis of robot successfully applied in other fields. This paper designs and realizes a tracked mobile robot of air quality monitoring, which can be used to monitor air quality for the pollution accident in industrial parks and regular management.

  10. Horizon Dam design, construction, and quality management

    Energy Technology Data Exchange (ETDEWEB)

    Patrick, B. [EBA Engineering Consultants Ltd., Nanaimo, BC (Canada); Sisson, R. [Canadian Natural Resources Ltd., Fort McMurray, AB (Canada)

    2010-07-01

    This paper discussed the design and construction of the Tar River Diversion Dam and the quality management system (QMS) used during construction. The project was unusual in that the company constructed the project using its own workforce, without contractors, under challenging schedule and site conditions. The topography, geology and geotechnical aspects of the site were discussed along with the embankment design, seepage control measures and construction execution. The QMS was designed to fit the needs of the unique construction execution strategy and meet safety, reliability, performance, and operation requirements, comply with all regulations and approval conditions, and identify and communicate risk to the appropriate entity. Specifications and construction procedures had to be modified to accommodate equipment operators trained with the skills and techniques of mine operations, not those associated with conventional civil construction projects. Foundation movement identified during construction required mid-build design changes, construction rescheduling, and additional deformation analyses to determine long-term stability. The QMS allowed changes in the understanding of site conditions to be quickly addressed and risks to be identified and cost-effectively mitigated. Design consultants were used to modify designs and appropriately identify and mitigate risks. The approach to embankment construction was successful because the QMS included processes for change management, issue resolution, and risk-benefit assessment, and because experienced personnel had a regular presence on the construction site and worked collaboratively. The effective QMS was deemed to be integral to the success of the construction project. 1 tab., 7 figs.

  11. Indoor air quality – buildings design

    Directory of Open Access Journals (Sweden)

    Juhásová Šenitková Ingrid

    2017-01-01

    Full Text Available Growing attention is being paid to indoor air quality as one of the main health and well-being factors. The indoor research is concerned mostly to indoor air chemicals within indoor engineering related to building design. The providing good indoor air quality can be achieved effectively by avoiding or reducing indoor air pollution sources and by selecting low-polluting building materials, both being low-cost and energyefficient solutions. On the base of the last large experimental monitoring results, it was possible to know the level of selected indoor chemicals occurrence, rank them as well as to predict the tendencies of occurrence and establish the priorities for the future. There has been very limited attention to rigorous analysis of buildings actual environmental impacts to date. Healthy/green/sustainable building practices are typically applied in unsystematic and inconsistent ways often without resolution of inherent conflicts between and among such practices. Designers, products manufacturers, constructors, and owners declare their buildings and the applied technologies to be beneficial to the environment without validating those claims.

  12. 77 FR 30087 - Air Quality Designations for the 2008 Ozone National Ambient Air Quality Standards

    Science.gov (United States)

    2012-05-21

    ... and 81 Air Quality Designations for the 2008 Ozone National Ambient Air Quality Standards; Implementation of the 2008 National Ambient Air Quality Standards for Ozone: Nonattainment Area Classifications...-9668-2] RIN 2060-AP37 Air Quality Designations for the 2008 Ozone National Ambient Air Quality...

  13. Product quality driven food process design

    NARCIS (Netherlands)

    Hadiyanto, M.

    2007-01-01

    Consumers evaluate food products on their quality, and thus the product quality is a main target in industrial food production. In the last decade there has been a remarkable increase of interest of the food industry to put food product quality central in innovation. However, quality itself is

  14. HVAC design guidelines for effective indoor air quality

    International Nuclear Information System (INIS)

    Bladykas, M.P.

    1993-01-01

    Building owners, designers and occupants need to consider all the design measures that contribute to high indoor air quality. Building occupants, furnishings, equipment, and ambient air pollution all contribute to surmounting indoor air quality concerns. However, these can be minimized by following HVAC design guidelines which promote high indoor air quality while maintaining reasonable energy-efficiency. The possible liabilities and loss of business productivity due to air quality problems are too great to ignore

  15. Quality design of belite–melilite clinker

    Energy Technology Data Exchange (ETDEWEB)

    Kurokawa, Daisuke, E-mail: daisuke_kurokawa@taiheiyo-cement.co.jp [R and D center, Taiheiyo Cement Corporation, Chiba 285-8655 (Japan); Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466-8555 (Japan); Honma, Kenichi; Hirao, Hiroshi [R and D center, Taiheiyo Cement Corporation, Chiba 285-8655 (Japan); Fukuda, Koichiro [Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya 466-8555 (Japan)

    2013-12-15

    We have developed a new cement clinker, consisting mainly of belite and melilite, which is capable of increasing the amount of recycled waste as a part of its raw materials. We analyzed clinkers with a wide range of compositions, and clarified the quantitative relationship between the chemical and mineral compositions. Clinkers consisting mostly of belite and melilite were successfully obtained at the CaO/SiO{sub 2} mass ratio of 1.7 to 1.9. Test cements were prepared using these clinkers and mixed with OPC for the evaluation of fluidity and strength. The belite–melilite cement was found to have good fluidity, and the belite–melilite cement mixed with OPC at up to 30% exhibited a satisfactory long term strength equivalent to the OPC, demonstrating the potential as an alternative to OPC. Electron probe microanalysis revealed the relatively high concentration of diphosphorus pentaoxide in belite, suggesting this component might contribute to the strength enhancement of the cement. -- Highlights: •A new cement clinker consisting mainly of belite and melilite was designed. •The clinker enables the use of various recycled wastes as part of its raw materials. •The relationship between the chemical and mineral compositions was clarified. •This cement mixed with OPC at up to 30% exhibited a good quality equivalent to OPC.

  16. 76 FR 72097 - Air Quality Designations for the 2008 Lead (Pb) National Ambient Air Quality Standards

    Science.gov (United States)

    2011-11-22

    ... Air Quality Designations for the 2008 Lead (Pb) National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This rule establishes air quality designations for most areas in the United States for the 2008 lead (Pb) National Ambient Air Quality Standards...

  17. Active magnetic bearing for use in compressors and other turbomachinery

    International Nuclear Information System (INIS)

    Hennau, J.N.

    1989-01-01

    Active magnetic bearings and dry gas seals are now in operation on quite a number of compressors, turbines and generators, proving than an oil-free system is actually working and that furthermore, it has merits in energy savings, rotor dynamic monitoring and improved reliability. The technology of active magnetic bearing has been developed mainly in France after the Second World War for space application, but soon there appeared the large possibilities in industrial applications starting with the vacuum industry (turbomolecular pump), followed by the machine tool industry (high power and high speed milling and grinding spindles) and the large turbomachinery field (centrifugal compressors, blowers, steam and gas turbines, turbogenerators). Merits of the active magnetic bearing vary from one application to another, but they all derive from the fact that we have no contact between the rotor and the stator and that the electronic control of the bearings can cope with the rotor dynamics and provide useful information on the operating conditions

  18. Meanline Analysis of Turbines with Choked Flow in the Object-Oriented Turbomachinery Analysis Code

    Science.gov (United States)

    Hendricks, Eric S.

    2016-01-01

    The Object-Oriented Turbomachinery Analysis Code (OTAC) is a new meanline/streamline turbomachinery modeling tool being developed at NASA GRC. During the development process, a limitation of the code was discovered in relation to the analysis of choked flow in axial turbines. This paper describes the relevant physics for choked flow as well as the changes made to OTAC to enable analysis in this flow regime.

  19. An overview of turbomachinery project in Malaysian oil and gas industry

    Science.gov (United States)

    Abd. Rahman Sabri, Harris; Rahim, Abd. Rahman Abdul; Yew, Wong Kuan; Ismail, Syuhaida

    2017-12-01

    Being the most demanding, challenging and exciting engineering and technological advances has provided escalated interests amongst the engineers at large to venture into the oil and gas (O&G) industry. Although claimed as the most expensive industry in the world via the utilisation of critical equipments, the O&G industry is still recording notorius failures in its project management especially due to turbomachinery issues, the heart equipment of any O&G project. Therefore, it is important for this paper to review turbomachinery project as one of the long lead items during project executions that is also proven to be the most costly and expensive equipment. This paper therefore discusses the gaps in turbomachinery studies via literature review in highlighting its application in O&G projects. It is found that the main components of turbomachinery are driver and driven equipment, which are applied for mechanical equipment, Electric Power Generation and heat generation for Combined Cycled Configuration. Important variables for turbomachinery selection include: (1) process requirement; (2) site location; (3) driver selection; (4) equipment sparing philosophy; (5) efficiency and reliability; (6) operability and maintainability; and (7) cost. It is hoped that this paper would lead to the successful project management of turbomachinery in the O&G industry.

  20. Helium turbomachinery operating experience from gas turbine power plants and test facilities

    International Nuclear Information System (INIS)

    McDonald, Colin F.

    2012-01-01

    The closed-cycle gas turbine, pioneered and deployed in Europe, is not well known in the USA. Since nuclear power plant studies currently being conducted in several countries involve the coupling of a high temperature gas-cooled nuclear reactor with a helium closed-cycle gas turbine power conversion system, the experience gained from operated helium turbomachinery is the focus of this paper. A study done as early as 1945 foresaw the use of a helium closed-cycle gas turbine coupled with a high temperature gas-cooled nuclear reactor, and some two decades later this was investigated but not implemented because of lack of technology readiness. However, the first practical use of helium as a gas turbine working fluid was recognized for cryogenic processes, and the first two small fossil-fired helium gas turbines to operate were in the USA for air liquefaction and nitrogen production facilities. In the 1970's a larger helium gas turbine plant and helium test facilities were built and operated in Germany to establish technology bases for a projected future high efficiency large nuclear gas turbine power plant concept. This review paper covers the experience gained, and the lessons learned from the operation of helium gas turbine plants and related test facilities, and puts these into perspective since over three decades have passed since they were deployed. An understanding of the many unexpected events encountered, and how the problems, some of them serious, were resolved is important to avoid them being replicated in future helium turbomachines. The valuable lessons learned in the past, in many cases the hard way, particularly from the operation in Germany of the Oberhausen II 50 MWe helium gas turbine plant, and the technical know-how gained from the formidable HHV helium turbine test facility, are viewed as being germane in the context of current helium turbomachine design work being done for future high efficiency nuclear gas turbine plant concepts. - Highlights:

  1. Product quality driven design of bakery operations using dynamic optimization

    NARCIS (Netherlands)

    Hadiyanto, M.; Esveld, D.C.; Boom, R.M.; Straten, van G.; Boxtel, van A.J.B.

    2008-01-01

    Abstract Quality driven design uses specified product qualities as a starting point for process design. By backward reasoning the required process conditions and processing system were found. In this work dynamic optimization was used as a tool to generate processing solutions for baking processes

  2. Spectrum analysis on quality requirements consideration in software design documents.

    Science.gov (United States)

    Kaiya, Haruhiko; Umemura, Masahiro; Ogata, Shinpei; Kaijiri, Kenji

    2013-12-01

    Software quality requirements defined in the requirements analysis stage should be implemented in the final products, such as source codes and system deployment. To guarantee this meta-requirement, quality requirements should be considered in the intermediate stages, such as the design stage or the architectural definition stage. We propose a novel method for checking whether quality requirements are considered in the design stage. In this method, a technique called "spectrum analysis for quality requirements" is applied not only to requirements specifications but also to design documents. The technique enables us to derive the spectrum of a document, and quality requirements considerations in the document are numerically represented in the spectrum. We can thus objectively identify whether the considerations of quality requirements in a requirements document are adapted to its design document. To validate the method, we applied it to commercial software systems with the help of a supporting tool, and we confirmed that the method worked well.

  3. Creating Practitioners of Design for Quality through Education

    DEFF Research Database (Denmark)

    Robotham, Antony John

    1998-01-01

    The above paper described my experiences of teaching engineering students to be able to create products of the highest design quality. The paper identifies the need to have a good understanding of the needs of the customer and to be able to create products, which have a range of quality attributes...... would be of higher quality and provide greater customer satisfaction if designers were continually aware of all life-phase needs....

  4. Experience with quality assurance in fuel design and manufacturing

    International Nuclear Information System (INIS)

    Holzer, R.; Nilson, F.

    1984-01-01

    The Quality Assurance/Quality Control activities for nuclear fuel design and manufacturing described here are coordinated under a common ''Quality Assurance System For Fuel Assemblies and Associated Core Components'' which regulates the QA-functions of the development, design and manufacturing of fuel assemblies independent of the organizational assignment of the contributing technical groups. Some essential characteristics of the system are shown, using examples from design control, procurement, manufacturing and qualification of special processes. The experience is very good, it allowed a flexible and well controlled implementation of design and manufacturing innovations and contributed to the overall good fuel behavior. (orig.)

  5. Indoor Air Quality Design Tools for Schools

    Science.gov (United States)

    The information available here is presented as a tool to help school districts and facility planners design the next generation of learning environments so that the school facility will help, rather than hinder, schools in achieving their core mission

  6. Design an Indoor Air Quality Controller Based on LPC2478

    Directory of Open Access Journals (Sweden)

    Shi Shuheng

    2014-07-01

    Full Text Available Indoor air quality is very important to our lives, because we spend most of our time indoor. In order to improve the air quality of indoor, this paper designs an indoor environment quality monitoring and controlling system based on ARM microcontroller LPC2478. It will do a real-time monitoring work for detecting the indoor environmental factors and comprehensively evaluate its air quality level. While the indoor air quality status is "poor", this intelligent system will automatically start the heat exchange ventilator for indoor environmental quality improvement. The results compared to traditional natural ventilation method show the better performance of proposed system.

  7. Incorporating Handling Qualities Analysis into Rotorcraft Conceptual Design

    Science.gov (United States)

    Lawrence, Ben

    2014-01-01

    This paper describes the initial development of a framework to incorporate handling qualities analyses into a rotorcraft conceptual design process. In particular, the paper describes how rotorcraft conceptual design level data can be used to generate flight dynamics models for handling qualities analyses. Also, methods are described that couple a basic stability augmentation system to the rotorcraft flight dynamics model to extend analysis to beyond that of the bare airframe. A methodology for calculating the handling qualities characteristics of the flight dynamics models and for comparing the results to ADS-33E criteria is described. Preliminary results from the application of the handling qualities analysis for variations in key rotorcraft design parameters of main rotor radius, blade chord, hub stiffness and flap moment of inertia are shown. Varying relationships, with counteracting trends for different handling qualities criteria and different flight speeds are exhibited, with the action of the control system playing a complex part in the outcomes. Overall, the paper demonstrates how a broad array of technical issues across flight dynamics stability and control, simulation and modeling, control law design and handling qualities testing and evaluation had to be confronted to implement even a moderately comprehensive handling qualities analysis of relatively low fidelity models. A key outstanding issue is to how to 'close the loop' with an overall design process, and options for the exploration of how to feedback handling qualities results to a conceptual design process are proposed for future work.

  8. Bike Infrastructures and Design Qualities: Enhancing Cycling

    DEFF Research Database (Denmark)

    Silva, Victor; Jensen, Ole B.; Harder, Henrik

    2011-01-01

    as well as to describe what specific design element primarily motivated them to travel by bike. The findings highlight the critical role of fast connectivity and fast bike lanes in motivating cyclists to ride their bikes more often. It also indicates that it is challenging to ensure the perception...... infrastructures. This article aims to present findings of the research project titled Bikeability – funded by the Danish Research Council. The overall purpose of the Bikeability project is to investigate and document relations between cycling motivation from different socio- demographic groups and distinct design...

  9. Application of project design peer review to improve quality assurance

    International Nuclear Information System (INIS)

    McClure, F.E.

    1989-01-01

    DOE ORDER 5481.1B Safety Analysis and Review Systems and DOE ORDER 6430.1A General Design Criteria require that the design of facilities shall incorporate the necessary Quality Assurance review requirements to assure that the established program quality assurance objectives are met in the design criteria and the construction documents. The use of Project Design Peer Review to satisfy these requirements is presented. The University of California manages the Lawrence Berkeley Laboratory, the Lawrence Livermore National Laboratory, and the Los Alamos National Scientific Laboratory. The 1988 University Seismic Safety Policy requires the use of independent Project Design Peer Review in its capital improvement and seismic reconstruction program

  10. Quality and rules for mechanical aspects of tangible interaction design

    NARCIS (Netherlands)

    Broekhuijsen, M.J.; Delbressine, F.L.M.; Feijs, L.M.G.

    2011-01-01

    This paper describes the application of Exact Kinematic Constraint Design to designs meant for tangible interaction with users. The paper gives rules for generating high quality mechanical designs for tangible interactions. Each rule is explained using examples made in LEGO and real world examples.

  11. CAD/CAM: improved design quality, increased productivity

    Energy Technology Data Exchange (ETDEWEB)

    Evans, D. E.; England, J.

    1980-01-01

    Maintaining productivity levels while assuring the quality of engineering products grows increasingly more difficult and costly for industries such as the energy industry which are heavily committed to product design. The man/machine interface made possible through the development of computer-aided design/computer-aided manufacturing (CAD/CAM) technology can be applied to the design process as a tool for increased control to assure the quality of the final engineering product. The quality-control aspects of CAD/CAM technology are addressed in this presentation.

  12. Evaluation of turbulence models for turbomachinery unsteady three-dimensional flows simulation; Evaluation de modeles de turbulence pour la simulation d'ecoulements tridimensionnels instationnaires en turbomachines

    Energy Technology Data Exchange (ETDEWEB)

    Dano, C.

    2003-01-15

    The objective of this thesis is to evaluate k-e, k-l and k-w low Reynolds two equation turbulence models for. A quadratic nonlinear k-l model is also implemented in this study. We analyze the two equation turbulence models capacity to predict the turbomachinery flows and the wakes. We are interested more particularly in the unsteady three dimensional configuration with rotor-stator interactions. A Gaussian distribution reproduces the upstream wake. This analysis is carried out in term of prediction quality but also in term of numerical behavior. Turbines and compressors configurations are tested. (author)

  13. Industrial aspects: materials, designing and quality

    International Nuclear Information System (INIS)

    Blanc, M.

    2008-01-01

    First, this article reviews the evolution of the PWR fuel assembly manufactured by Westinghouse over 30 years and secondly gives a glimpse of the industrial organization of Westinghouse. The progressive changes in the design of the fuel assembly can be illustrated by the materials used: first Inconel then zircaloy-4, zirlo and now the optimized zirlo. The Westinghouse nuclear fuel destined to French pressurized reactors is fabricated in either Sweden (Vasteras) or in Spain (Juzbado). Fuel tubes are produced in Usa (Blairsville) or in Sweden (Sandvik). In the last 5 years Westinghouse has launched important programs for improving industrial processes and final products to reach customer satisfaction. (A.C.)

  14. Dictionary quality and dictionary design: a methodology for ...

    African Journals Online (AJOL)

    Although recent dictionaries for the ESL market have been praised for their innovative design features, the prime concern of users, lexicographers and metalexicographers is the functional quality of the dictionary products provided for the market. The functional quality of dictionaries and the scientific assessment thereof ...

  15. Forced response of turbomachinery part span shrouds-linked blading; Reponse forcee des aubages de turbomachines liaisonnes par nageoires

    Energy Technology Data Exchange (ETDEWEB)

    Ravoux, J.

    2003-06-15

    This work treats of the design of blading systems fitted with part span shrouds (snubber) for turbo-machineries. The first chapter makes a status of the existing calculation techniques for blading systems. The second chapter presents the experimental system developed for the study, the different implementations of its exploitation and its potentialities. The third chapter presents the numerical and experimental results linked with a linear approach: this approach allows the validation of the experimental system and the adjustment of numerical models. The fourth chapter sets up and validates the numerical and experimental tools and techniques linked with the exhaustive exploitation of the system. Finally, a synthesis of the main results is presented with their perspectives for future works. (J.S.)

  16. Heat Treatment Used to Strengthen Enabling Coating Technology for Oil-Free Turbomachinery

    Science.gov (United States)

    Edmonds, Brian J.; DellaCorte, Christopher

    2002-01-01

    The PS304 high-temperature solid lubricant coating is a key enabling technology for Oil- Free turbomachinery propulsion and power systems. Breakthroughs in the performance of advanced foil air bearings and improvements in computer-based finite element modeling techniques are the key technologies enabling the development of Oil-Free aircraft engines being pursued by the Oil-Free Turbomachinery team at the NASA Glenn Research Center. PS304 is a plasma spray coating applied to the surface of shafts operating against foil air bearings or in any other component requiring solid lubrication at high temperatures, where conventional materials such as graphite cannot function.

  17. Research Capabilities for Oil-Free Turbomachinery Expanded by New Rotordynamic Simulator Facility

    Science.gov (United States)

    Howard, Samuel A.

    2004-01-01

    A new test rig has been developed for simulating high-speed turbomachinery shafting using Oil-Free foil air bearing technology. Foil air journal bearings are self-acting hydrodynamic bearings with a flexible inner sleeve surface using air as the lubricant. These bearings have been used in turbomachinery, primarily air cycle machines, for the past four decades to eliminate the need for oil lubrication. More recently, interest has been growing in applying foil bearings to aircraft gas turbine engines. They offer potential improvements in efficiency and power density, decreased maintenance costs, and other secondary benefits. The goal of applying foil air bearings to aircraft gas turbine engines prompted the fabrication of this test rig. The facility enables bearing designers to test potential bearing designs with shafts that simulate the rotating components of a target engine without the high cost of building actual flight hardware. The data collected from this rig can be used to make changes to the shaft and bearings in subsequent design iterations. The rest of this article describes the new test rig and demonstrates some of its capabilities with an initial simulated shaft system. The test rig has two support structures, each housing a foil air journal bearing. The structures are designed to accept any size foil journal bearing smaller than 63 mm (2.5 in.) in diameter. The bearing support structures are mounted to a 91- by 152-cm (3- by 5-ft) table and can be separated by as much as 122 cm (4 ft) and as little as 20 cm (8 in.) to accommodate a wide range of shaft sizes. In the initial configuration, a 9.5-cm (3.75-in.) impulse air turbine drives the test shaft. The impulse turbine, as well as virtually any number of "dummy" compressor and turbine disks, can be mounted on the shaft inboard or outboard of the bearings. This flexibility allows researchers to simulate various engine shaft configurations. The bearing support structures include a unique bearing mounting

  18. On Design Experiment Teaching in Engineering Quality Cultivation

    Science.gov (United States)

    Chen, Xiao

    2008-01-01

    Design experiment refers to that designed and conducted by students independently and is surely an important method to cultivate students' comprehensive quality. According to the development and requirements of experimental teaching, this article carries out a study and analysis on the purpose, significance, denotation, connotation and…

  19. Design decisions in workflow management and quality of work.

    NARCIS (Netherlands)

    Waal, B.M.E. de; Batenburg, R.

    2009-01-01

    In this paper, the design and implementation of a workflow management (WFM) system in a large Dutch social insurance organisation is described. The effect of workflow design decisions on the quality of work is explored theoretically and empirically, using the model of Zur Mühlen as a frame of

  20. Design and Development of Mobile Phone Using Quality Function Deployment

    Directory of Open Access Journals (Sweden)

    Hamid Ullah

    2017-03-01

    Full Text Available The paper presents design and development of mobile phone using Quality Function Deployment. Quality Function Deployment is one of the total quality management tools used to convert customers’ needs into design specifications. A market survey is conducted to find out the voice of customer. The Voice of the Customer is converted into customers’ needs. Relative importance is assigned to customers’ needs. A list of technical requirements that could fulfill the customers’ needs is produced. A relationship matrix is developed between the customers’ needs and the technical requirements. The relationship matrix is converted into the House of Quality. Output from the House of Quality is used in concept generation of mobile phone. Concept generation is followed by concept selection. Final improved model of the mobile phone is presented.

  1. Bone biopsy needles. Mechanical properties, needle design and specimen quality

    International Nuclear Information System (INIS)

    Keulers, Annika; Penzkofer, T.; Cunha-Cruz, V.C.; Bruners, P.; Helmholtz Inst. fuer biomedizinische Technik, Aachen; Braunschweig, T.; Schmitz-Rode, T.; Mahnken, A.; Helmholtz Inst. fuer biomedizinische Technik, Aachen

    2011-01-01

    To quantitatively analyze differences in mechanical properties, needle design including signs of wear, subjective handling and specimen quality of bone biopsy needles. Materials and Methods: In this study 19 different bone biopsy systems (total 38; 2 /type) were examined. With each biopsy needle five consecutive samples were obtained from vertebral bodies of swine. During puncture a force-torques sensor measured the mechanical properties and subjective handling was assessed. Before and after each biopsy the needles were investigated using a profile projector and signs of wear were recorded. Afterwards, a pathologist semi-quantitatively examined the specimen regarding sample quality. The overall evaluation considered mechanical properties, needle wear, subjective handling and sample quality. Differences were assessed for statistical significance using ANOVA and t-test. Results: Needle diameter (p = 0.003) as well as needle design (p = 0.008) affect the mechanical properties significantly. Franseen design is significantly superior to other needle designs. Besides, length reduction recorded by the profile projector, as a quality criterion showed notable distinctions in between the needle designs. Conclusion: Bone biopsy needles vary significantly in performance. Needle design has an important influence on mechanical properties, handling and specimen quality. Detailed knowledge of those parameters would improve selecting the appropriate bone biopsy needle. (orig.)

  2. Designing power transformers for Sizewell 'B' as quality products

    International Nuclear Information System (INIS)

    White, A.; Poole, C.W.

    1992-01-01

    At the beginning of 1990, Nuclear Electric plc., then a Division of the CEGB, placed a contract with GEC ALSTHOM Transformers Limited of Stafford for the design, supply and installation of the main transformers for the Sizewell B electrical system. The following transformers are being provided under this contract; two Generator Transformers, two Station Transformers, two Unit Transformers and two Fault Limiting Reactors. The main objective of this paper is to describe the quality assurance philosophies applied to the design of these transformers to ensure that the performance requirements were met in full and to describe how these philosophies were converted into a practical working system. The paper does not set out to present a detailed technical appreciation of the transformers themselves but rather, to demonstrate that by addressing quality in the design and design processes, reliable and efficient items of high value, capital equipment result from the partnership in quality between supplier and customer. (Author)

  3. Six Sigma Quality Management System and Design of Risk-based Statistical Quality Control.

    Science.gov (United States)

    Westgard, James O; Westgard, Sten A

    2017-03-01

    Six sigma concepts provide a quality management system (QMS) with many useful tools for managing quality in medical laboratories. This Six Sigma QMS is driven by the quality required for the intended use of a test. The most useful form for this quality requirement is the allowable total error. Calculation of a sigma-metric provides the best predictor of risk for an analytical examination process, as well as a design parameter for selecting the statistical quality control (SQC) procedure necessary to detect medically important errors. Simple point estimates of sigma at medical decision concentrations are sufficient for laboratory applications. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Quality-control design for surface-water sampling in the National Water-Quality Network

    Science.gov (United States)

    Riskin, Melissa L.; Reutter, David C.; Martin, Jeffrey D.; Mueller, David K.

    2018-04-10

    The data-quality objectives for samples collected at surface-water sites in the National Water-Quality Network include estimating the extent to which contamination, matrix effects, and measurement variability affect interpretation of environmental conditions. Quality-control samples provide insight into how well the samples collected at surface-water sites represent the true environmental conditions. Quality-control samples used in this program include field blanks, replicates, and field matrix spikes. This report describes the design for collection of these quality-control samples and the data management needed to properly identify these samples in the U.S. Geological Survey’s national database.

  5. Quality assurance in the design of nuclear power plants

    International Nuclear Information System (INIS)

    1981-01-01

    This Safety Guide provides the requirements and recommendations related to the establishment and implementation of quality assurance for design of items for a nuclear power plant. The requirements of this Guide shall be applied to the extent necessary during all constituent activities of the nuclear power plant project, such as design, manufacture, construction, commissioning and operations. Its requirements and recommendations shall be implemented, as appropriate, by the responsible organization or by its designated representatives: by plant designers, architect-engineers or manufacturers, when involved in performing design activities related to items to be manufactured; by site constructors, when involved in field engineering activities; by plant operators and other organizations, when involved in design activities related to plant modifications or to selection of spare or replacement parts; and by design consultants and other technical organizations, when performing any engineering activity that affects the work of other design organizations during various stages of nuclear power plant projects

  6. Recent developments in turbomachinery component materials and manufacturing challenges for aero engine applications

    Science.gov (United States)

    Srinivas, G.; Raghunandana, K.; Satish Shenoy, B.

    2018-02-01

    In the recent years the development of turbomachinery materials performance enhancement plays a vital role especially in aircraft air breathing engines like turbojet engine, turboprop engine, turboshaft engine and turbofan engines. Especially the transonic flow engines required highly sophisticated materials where it can sustain the entire thrust which can create by the engine. The main objective of this paper is to give an overview of the present cost-effective and technological capabilities process for turbomachinery component materials. Especially the main focus is given to study the Electro physical, Photonic additive removal process and Electro chemical process for turbomachinery parts manufacture. The aeronautical propulsion based technologies are reviewed thoroughly where in surface reliability, geometrical precession, and material removal and highly strengthened composite material deposition rates usually difficult to cut dedicated steels, Titanium and Nickel based alloys. In this paper the past aeronautical and propulsion mechanical based manufacturing technologies, current sophisticated technologies and also future challenging material processing techniques are covered. The paper also focuses on the brief description of turbomachinery components of shaping process and coating in aeromechanical applications.

  7. Helping to reduce turbomachinery losses through advanced technology and on-line expertise

    Energy Technology Data Exchange (ETDEWEB)

    Feigel, R.E. [Hartford Steam Boiler Inspection & Insurance Co., Hartford, CT (United States)

    1994-12-31

    It`s clear that turbomachinery poses a set of unique problems for risk managers. The size of the equipment, the role it often takes in production and the severity of a loss all combine to make a risk manager`s job that much more difficult. But while the job may be difficult, it`s not impossible. Through a combination of advanced technology, regular predictive maintenance and some expert advice, today`s risk managers, working with plant operational personnel, are reducing major turbomachinery losses. There are several telltale signs that warn plant personnel of an impending turbomachinery failure. One is vibration. All turbomachinery will vibrate at some level, even when in good working condition. But a change in the vibration level usually indicates a change in the machine`s performance. If plant personnel can detect a change early enough, they may be able to avoid an unscheduled shutdown. Hartford Steam Boiler recently introduced a periodic vibration data collection program called DATALERT{trademark} to help its customers separate problem from non-problem machines. As a result, companies can focus resources on equipment that needs immediate attention. And equipment in good working condition doesn`t tie up resources unnecessarily at the next maintenance turnaround. DATALERT is an integrated machinery vibration data collecting and expert analysis system developed by Hartford Steam Boiler to assist customers in preventing rotating machine downtime or losses. The data collection program is described.

  8. Extending cluster Lot Quality Assurance Sampling designs for surveillance programs

    OpenAIRE

    Hund, Lauren; Pagano, Marcello

    2014-01-01

    Lot quality assurance sampling (LQAS) has a long history of applications in industrial quality control. LQAS is frequently used for rapid surveillance in global health settings, with areas classified as poor or acceptable performance based on the binary classification of an indicator. Historically, LQAS surveys have relied on simple random samples from the population; however, implementing two-stage cluster designs for surveillance sampling is often more cost-effective than ...

  9. 76 FR 76048 - Air Quality Designations for the 2008 Lead (Pb) National Ambient Air Quality Standards

    Science.gov (United States)

    2011-12-06

    ... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 81 [EPA-HQ-OAR-2009-0443; FRL-9492-3] RIN 2060-AR17 Air Quality Designations for the 2008 Lead (Pb) National Ambient Air Quality Standards Correction In rule document 2011-29460 appearing on pages 72097-72120 in the issues of Tuesday, November 22, 2011...

  10. The Process of Optimizing Mechanical Sound Quality in Product Design

    DEFF Research Database (Denmark)

    Eriksen, Kaare; Holst, Thomas

    2011-01-01

    The research field concerning optimizing product sound quality is a relatively unexplored area, and may become difficult for designers to operate in. To some degree, sound is a highly subjective parameter, which is normally targeted sound specialists. This paper describes the theoretical...... and practical background for managing a process of optimizing the mechanical sound quality in a product design by using simple tools and workshops systematically. The procedure is illustrated by a case study of a computer navigation tool (computer mouse or mouse). The process is divided into 4 phases, which...... clarify the importance of product sound, defining perceptive demands identified by users, and, finally, how to suggest mechanical principles for modification of an existing sound design. The optimized mechanical sound design is followed by tests on users of the product in its use context. The result...

  11. A durability test rig and methodology for erosion-resistant blade coatings in turbomachinery

    Science.gov (United States)

    Leithead, Sean Gregory

    A durability test rig for erosion-resistant gas turbine engine compressor blade coatings was designed, completed and commissioned. Bare and coated 17-4PH steel V103-profile blades were rotated at up to 11500 rpm and impacted with Garnet sand for 5 hours at an average concentration of 2.51 gm3of air , at a blade leading edge Mach number of 0.50. The rig was determined to be an acceptable first stage axial compressor representation. Two types of 16 microm-thick coatings were tested: Titanium Nitride (TiN) and Chromium-Aluminum-Titanium Nitride (CrAlTiN), both applied using an Arc Physical Vapour Deposition technique at the National Research Council in Ottawa, Canada. A Leithead-Allan-Zhao (LAZ) score was created to compare the durability performance of uncoated and coated blades based on mass-loss and blade dimension changes. The bare blades' LAZ score was set as a benchmark of 1.00. The TiN-coated and CrAlTiN-coated blades obtained LAZ scores of 0.69 and 0.41, respectively. A lower score meant a more erosion-resistant coating. Major modes of blade wear included: trailing edge, leading edge and the rear suction surface. Trailing edge thickness was reduced, the leading edge became blunt, and the rear suction surface was scrubbed by overtip and recirculation zone vortices. It was found that the erosion effects of vortex flow were significant. Erosion damage due to reflected particles was not present due to the low blade solidity of 0.7. The rig is best suited for studying the performance of erosion-resistant coatings after they are proven effective in ASTM standardized testing. Keywords: erosion, compressor, coatings, turbomachinery, erosion rate, blade, experimental, gas turbine engine

  12. The design & delivery of quality services: A paradigm shift

    Directory of Open Access Journals (Sweden)

    D. B.H. Smith

    2002-12-01

    Full Text Available As result of the increasingly important role information technology (IT is playing in service provision, less person-to-person contact will in future be made during service provision. Highly skilled specialists will make the remaining contact. Emphasis will shift to speed of delivery, with logistics playing an important role. The designers of services must take these factors into account if they wish to design quality services.

  13. Quality Control through Design and Process: Gambrel Roof Truss Challenge

    Science.gov (United States)

    Ward, Dell; Jones, James

    2011-01-01

    Customers determine whether a product fulfills their needs or satisfies them. "Quality control", then, is the process of finding out what the customer wants, along with designing, producing, delivering, and servicing the product--and ultimately satisfying the customer's expectations. For many years, people considered a product to be of good…

  14. Design and control of a DSTATCOM for power quality improvement ...

    African Journals Online (AJOL)

    This paper presents the design of a three phase DSTATCOM (Distribution Static Compensator) and its control algorithm based on correlation and cross correlation function approach for power quality improvement under linear/ nonlinear loads in a distribution system. In this approach, an extraction of fundamental active and ...

  15. Designing the model for evaluating business quality in Croatia

    Directory of Open Access Journals (Sweden)

    Ana Ježovita

    2015-01-01

    Full Text Available The main objective of the paper includes designing a model for evaluating the financial quality of business operations. In that context, for the paper purposes, the financial quality of business operations is defined as an ability to achieve adequate value of individual financial ratios for financial position and performance evaluation. The objective of the model is to obtain comprehensive conclusion about the financial quality of business operation using only value of the function. Data used for designing the model is limited to financial data available from the annual balance sheet and income statement. Those limitations offer the opportunity for all sizes of companies from the non-financial business economy sector to use the designed model for evaluation purposes. Statistical methods used for designing the model are multivariate discriminant analysis and logistic regression. Discriminant analysis resulted in the function which includes five individual financial ratios with the best discriminant power. Respecting the results obtained in the classification matrix with classification accuracy of 95.92% by the original sample, or accuracy of 96.06% for the independent sample, it can be concluded that it is possible to evaluate the financial quality of business operations of companies in Croatia by using the model composed of individual financial ratios. Conducted logistic regression confirms the results obtained using discriminant analysis.

  16. Ensuring suitable quality of clinical measurements through design.

    Science.gov (United States)

    Orzechowski, Anthony; Petrides, Victoria; Scopp, Richard

    2018-04-17

    To design and deliver high quality, safe and effective products, manufacturers of in vitro diagnostic (IVD) products follow a structured, traceable process for controlling the uncertainty of results reported from their measurement systems. This process and its results however, are not often shared in detail with those outside of the manufacturing company. The objective of this paper is to facilitate discussion by describing some of the best practices used during the IVD design and development process, highlighting some design challenges manufacturers face, and to offer ideas for how IVD manufacturers and laboratories could work together to drive further improvement to public health. Copyright © 2018. Published by Elsevier Inc.

  17. Applying Quality by Design Concepts to Pharmacy Compounding.

    Science.gov (United States)

    Timko, Robert J

    2015-01-01

    Compounding of medications is an important part of the practice of the pharmacy profession. Because compounded medications do not have U.S. Food and Drug Administration approval, a pharmacist has the responsibility to ensure that compounded medications are of suitable quality, safety, and efficacy. The Federal Government and numerous states have updated their laws and regulations regarding pharmacy compounding as a result of recent quality issues. Compounding pharmacists are expected to follow good preparation prodecures in their compounding practices in much the same way pharmaceutical manufacturers are required to follow Current Good Manufacturing Procedures as detailed in the United States Code of Federal Regulations. Application of Quality by Design concepts to the preparation process for a compounded medication can help in understanding the potential pitfalls and the means to mitigate their impact. The goal is to build quality into the compounding process to ensure that the resultant compounded prescription meets the human or animal patients' requirements.

  18. Quality Affordable Housing: A Theoretical Framework for Planning and Design of Quality Housing

    Directory of Open Access Journals (Sweden)

    Noor Sharipah Sultan Sidi

    2011-10-01

    Full Text Available The provision of adequate, good or quality housing for the population has always been a major challenge and task for most nations in the world particularly the developing countries. As such various measures have been undertaken towards this end. However, the major constraint or problem in this respect has always been in defining the criteria for quality housing and establishing the standards of quality housing particularly with respect to the parameters in the determination of quality as some of the parameters are subjective and contextual such as psychological, cultural and environmental aspects. This paper is aimed at discussing the concept of quality housing and establishing the parameters and theoretical framework which can be used by researchers, town planners, architects, policy makers and others in the formulation of criteria / guidelines for the planning and design of quality housing.

  19. Air quality considerations for stormwater green street design

    International Nuclear Information System (INIS)

    Shaneyfelt, Kathryn M.; Anderson, Andrew R.; Kumar, Prashant; Hunt, William F.

    2017-01-01

    Green streets are increasingly being used as a stormwater management strategy to mitigate stormwater runoff at its source while providing other environmental and societal benefits, including connecting pedestrians to the street. Simultaneously, human exposure to particulate matter from urban transportation is of major concern worldwide due to the proximity of pedestrians, drivers, and cyclists to the emission sources. Vegetation used for stormwater treatment can help designers limit the exposure of people to air pollutants. This goal can be achieved through the deliberate placement of green streets, along with strategic planting schemes that maximize pollutant dispersion. This communication presents general design considerations for green streets that combine stormwater management and air quality goals. There is currently limited guidance on designing green streets for air quality considerations; this is the first communication to offer suggestions and advice for the design of green stormwater streets in regards to their effects on air quality. Street characteristics including (1) the width to height ratio of the street to the buildings, (2) the type of trees and their location, and (3) any prevailing winds can have an impact on pollutant concentrations within the street and along sidewalks. Vegetation within stormwater control measures has the ability to reduce particulate matter concentrations; however, it must be carefully selected and placed within the green street to promote the dispersion of air flow. - Highlights: • Green streets can be used for both stormwater and air quality management. • Design considerations must be made to minimize human exposure to air pollutants. • Urban vegetation can improve air quality with careful selection and placement.

  20. QFD emphasis of IME design

    Science.gov (United States)

    Erickson, C. M.; Martinez, A.

    1993-06-01

    The 1992 Integrated Modular Engine (IME) design concept, proposed to the Air Force Space Systems Division as a candidate for a National Launch System (NLS) upper stage, emphasized a detailed Quality Functional Deployment (QFD) procedure which set the basis for its final selection. With a list of engine requirements defined and prioritized by the customer, a QFD procedure was implemented where the characteristics of a number of engine and component configurations were assessed for degree of requirement satisfaction. The QFD process emphasized operability, cost, reliability and performance, with relative importance specified by the customer. Existing technology and near-term advanced technology were surveyed to achieve the required design strategies. In the process, advanced nozzles, advanced turbomachinery, valves, controls, and operational procedures were evaluated. The integrated arrangement of three conventional bell nozzle thrust chambers with two advanced turbopump sets selected as the configuration meeting all requirements was rated significantly ahead of the other candidates, including the Aerospike and horizontal flow nozzle configurations.

  1. Rethinking Space Design Standards Toward Quality Affordable Housing In Malaysia

    Directory of Open Access Journals (Sweden)

    Ishak Nor Haniza

    2016-01-01

    Full Text Available Provision of affordable housing is important to low- and middle-income population. A fit form of house will not only fulfil a basic human need for shelter, but it also contributes to physical and psychological well-being of the occupants. Excellent quality and affordable housing is an indication of a high quality of life. While writings exist on various aspects of the quality of affordable housing in Malaysia, discussion regarding space and design standards has scarcely been given any serious academic attention. Standards concerning residential development usually cover different aspects or stages of the development process. They can include planning standards, design standards, space standards and technical construction standards. The main concern of this paper is on space and design standards specifically. Space standard can be defined as a set of framework which dictates fixed internal space minimums. Meanwhile, design standard indicates design guidelines to ensure the functionality, comfortability and habitability of the house. This paper is concerned exclusively with indoor spaces of a house excluding external circulation spaces and service facilities (in case of strata housing. Its interest is in internal space as an aspect of housing quality. It can be concluded that one of the way forward will be to find the balance between providing adequate minimum spaces for resident satisfactions and having economic values for housing developers. This paper may be used as a valuable reference for authorities and policy makers to better address the best housing space design standards that would benefit not only the occupants, but also the local government and developers alike.

  2. Soft qualities in healthcare. Method and tools for soft qualities design in hospitals' built environments.

    Science.gov (United States)

    Capolongo, S; Bellini, E; Nachiero, D; Rebecchi, A; Buffoli, M

    2014-01-01

    The design of hospital environments is determined by functional requirements and technical regulations, as well as numerous protocols, which define the structure and system characteristics that such environments need to achieve. In order to improve people's well-being and the quality of their experience within public hospitals, design elements (soft qualities) are added to those 'necessary' features. The aim of this research has been to experiment a new design process and also to create health care spaces with high environmental quality and capable to meet users' emotional and perceptual needs. Such needs were investigated with the help of qualitative research tools and the design criteria for one of these soft qualities - colour - were subsequently defined on the basis of the findings. The colour scheme design for the new San Paolo Hospital Emergency Department in Milan was used as case study. Focus groups were fundamental in defining the project's goals and criteria. The issues raised have led to believe that the proper procedure is not the mere consultation of the users in order to define the goals: users should rather be involved in the whole design process and become co-agents of the choices that determine the environment characteristics, so as to meet the quality requirements identified by the users themselves. The case study has shown the possibility of developing a designing methodology made by three steps (or operational tools) in which users' groups are involved in the choices, loading to plan the environments where compliance with expectations is already implied and verified by means of the process itself. Thus, the method leads to the creation of soft qualities in Healthcare.

  3. MANAGING THE BUILDING DESIGN PROCESS FOR SUSTAINABILTY AND IMPROVED QUALITY

    Directory of Open Access Journals (Sweden)

    Sunday Bobadoye

    2006-01-01

    Full Text Available The essence of building design process and management for building sustainability in the creation and maintenance of a qualitative architectural product is investigated in this paper. The design process, concept of building sustainability and particularly the quality of the built environment are discussed. Akure, a state capital in Nigeria was used as a case study. The principles and indicators for sustainability of buildings and its implications on the quality of the environment are examined in details. Survey findings include the views of the professionals on the clients, perception on the design process as well as management of projects, and the implications on the quality of the ensuring products and the city’s environment. The data were factor analyzed using varimax rotation criterion (with Kaiser Normalization. The results revealed that five factors were effective, with one of them exhibiting the greatest variability and individual differences. The variables that loaded on this factor were really the aspects of the process and management relating to the clients. The findings also revealed the professionals’ wrong attitude towards design process as shown with a very high degree of variability in the study. The paper concludes by recommending the enactment and enforcement of relevant policies with adequate education of the people and the involvement of all the stakeholders in the management of building projects and environmental programmes for the realization of a qualitative architectural product.

  4. Air quality considerations for stormwater green street design.

    Science.gov (United States)

    Shaneyfelt, Kathryn M; Anderson, Andrew R; Kumar, Prashant; Hunt, William F

    2017-12-01

    Green streets are increasingly being used as a stormwater management strategy to mitigate stormwater runoff at its source while providing other environmental and societal benefits, including connecting pedestrians to the street. Simultaneously, human exposure to particulate matter from urban transportation is of major concern worldwide due to the proximity of pedestrians, drivers, and cyclists to the emission sources. Vegetation used for stormwater treatment can help designers limit the exposure of people to air pollutants. This goal can be achieved through the deliberate placement of green streets, along with strategic planting schemes that maximize pollutant dispersion. This communication presents general design considerations for green streets that combine stormwater management and air quality goals. There is currently limited guidance on designing green streets for air quality considerations; this is the first communication to offer suggestions and advice for the design of green stormwater streets in regards to their effects on air quality. Street characteristics including (1) the width to height ratio of the street to the buildings, (2) the type of trees and their location, and (3) any prevailing winds can have an impact on pollutant concentrations within the street and along sidewalks. Vegetation within stormwater control measures has the ability to reduce particulate matter concentrations; however, it must be carefully selected and placed within the green street to promote the dispersion of air flow. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Pharmaceutical product development: A quality by design approach

    Science.gov (United States)

    Pramod, Kannissery; Tahir, M. Abu; Charoo, Naseem A.; Ansari, Shahid H.; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development. PMID:27606256

  6. Pharmaceutical product development: A quality by design approach.

    Science.gov (United States)

    Pramod, Kannissery; Tahir, M Abu; Charoo, Naseem A; Ansari, Shahid H; Ali, Javed

    2016-01-01

    The application of quality by design (QbD) in pharmaceutical product development is now a thrust area for the regulatory authorities and the pharmaceutical industry. International Conference on Harmonization and United States Food and Drug Administration (USFDA) emphasized the principles and applications of QbD in pharmaceutical development in their guidance for the industry. QbD attributes are addressed in question-based review, developed by USFDA for chemistry, manufacturing, and controls section of abbreviated new drug applications. QbD principles, when implemented, lead to a successful product development, subsequent prompt regulatory approval, reduce exhaustive validation burden, and significantly reduce post-approval changes. The key elements of QbD viz., target product quality profile, critical quality attributes, risk assessments, design space, control strategy, product lifecycle management, and continual improvement are discussed to understand the performance of dosage forms within design space. Design of experiments, risk assessment tools, and process analytical technology are also discussed for their role in QbD. This review underlines the importance of QbD in inculcating science-based approach in pharmaceutical product development.

  7. 78 FR 47191 - Air Quality Designations for the 2010 Sulfur Dioxide (SO2) Primary National Ambient Air Quality...

    Science.gov (United States)

    2013-08-05

    ... Air Quality Designations for the 2010 Sulfur Dioxide (SO[bdi2]) Primary National Ambient Air Quality... air quality designations for certain areas in the United States for the 2010 primary Sulfur Dioxide (SO 2 ) National Ambient Air Quality Standard (NAAQS). The EPA is issuing this rule to identify areas...

  8. Mystery of Foil Air Bearings for Oil-free Turbomachinery Unlocked: Load Capacity Rule-of-thumb Allows Simple Estimation of Performance

    Science.gov (United States)

    DellaCorte, Christopher; Valco, Mark J.

    2002-01-01

    The Oil-Free Turbomachinery team at the NASA Glenn Research Center has unlocked one of the mysteries surrounding foil air bearing performance. Foil air bearings are self-acting hydrodynamic bearings that use ambient air, or any fluid, as their lubricant. In operation, the motion of the shaft's surface drags fluid into the bearing by viscous action, creating a pressurized lubricant film. This lubricating film separates the stationary foil bearing surface from the moving shaft and supports load. Foil bearings have been around for decades and are widely employed in the air cycle machines used for cabin pressurization and cooling aboard commercial jetliners. The Oil-Free Turbomachinery team is fostering the maturation of this technology for integration into advanced Oil-Free aircraft engines. Elimination of the engine oil system can significantly reduce weight and cost and could enable revolutionary new engine designs. Foil bearings, however, have complex elastic support structures (spring packs) that make the prediction of bearing performance, such as load capacity, difficult if not impossible. Researchers at Glenn recently found a link between foil bearing design and load capacity performance. The results have led to a simple rule-of-thumb that relates a bearing's size, speed, and design to its load capacity. Early simple designs (Generation I) had simple elastic (spring) support elements, and performance was limited. More advanced bearings (Generation III) with elastic supports, in which the stiffness is varied locally to optimize gas film pressures, exhibit load capacities that are more than double those of the best previous designs. This is shown graphically in the figure. These more advanced bearings have enabled industry to introduce commercial Oil-Free gas-turbine-based electrical generators and are allowing the aeropropulsion industry to incorporate the technology into aircraft engines. The rule-of-thumb enables engine and bearing designers to easily size and

  9. Conceptual design of a regional water quality screening model

    International Nuclear Information System (INIS)

    Davis, M.J.

    1981-01-01

    This water quality assessment methodology is intended to predict concentrations at future times and to estimate the impacts on water quality of energy-related activities (including industrial boilers). Estimates of impacts on water quality at future times are based on incremental changes in pollutant inputs to the body water. Important features of the model are: use of measured concentrations to account for existing conditions; consideration of incremental changes in pollutant loads; emphasis on the energy sector and industrial boilers; analysis restricted to streams only; no attempt to fully account for pollutant behavior; and flexible design, so that future improvements can be incorporated. The basic approach is very similar to the one used by Argonne's ARQUAL model but will allow more complex pollutant behavior and more flexibility in use

  10. Design of common software for quality control of SPECT

    International Nuclear Information System (INIS)

    Li Xiaohua; Gao Ruzhen; Chen Shengzu

    1993-01-01

    The goal of this study is to design a common testing system for SPECT quality control according to NEMA standard. Using the system, the performances of different types of SPECT can be tested, so that the acceptance testing, performance comparing and routine quality control for SPECT can be normalized. The system was based on IBM PC series of microcomputer. Testing data are acquired from various types of SPECT, then transferred into IBM PC through interface and tested with an unique testing program. Two parts were included: interface and SPECT testing program. It emphatically studied the managing program of RS232 interface, designing skills and the mathematic patterns of SPECT testing program. The system which was composed of 11 subroutines can be used to measure the performances for both gamma camera and SPECT. The system was tested on OMEGA 500/MCS 560 SPECT and the results showed that it is effective, accurate and easy to use

  11. Approach to design space from retrospective quality data.

    Science.gov (United States)

    Puñal Peces, Daniel; García-Montoya, Encarna; Manich, Albert; Suñé-Negre, Josep Maria; Pérez-Lozano, Pilar; Miñarro, Montse; Ticó, Josep Ramon

    2016-01-01

    Nowadays, the entire manufacturing process is based on the current GMPs, which emphasize the reproducibility of the process, and companies have a lot of recorded data about their processes. The establishment of the design space (DS) from retrospective data for a wet compression process. A design of experiments (DoE) with historical data from 4 years of industrial production has been carried out using the experimental factors as the results of the previous risk analysis and eight key parameters (quality specifications) that encompassed process and quality control data. Software Statgraphics 5.0 was applied, and data were processed to obtain eight DS as well as their safe and working ranges. Experience shows that it is possible to determine DS retrospectively, being the greatest difficulty in handling and processing of high amounts of data; however, the practicality of this study is very interesting as it let have the DS with minimal investment in experiments since actual production batch data are processed statistically.

  12. QUALITY IMPROVEMENT IN MULTIRESPONSE EXPERIMENTS THROUGH ROBUST DESIGN METHODOLOGY

    Directory of Open Access Journals (Sweden)

    M. Shilpa

    2012-06-01

    Full Text Available Robust design methodology aims at reducing the variability in the product performance in the presence of noise factors. Experiments involving simultaneous optimization of more than one quality characteristic are known as multiresponse experiments which are used in the development and improvement of industrial processes and products. In this paper, robust design methodology is applied to optimize the process parameters during a particular operation of rotary driving shaft manufacturing process. The three important quality characteristics of the shaft considered here are of type Nominal-the-best, Smaller-the-better and Fraction defective. Simultaneous optimization of these responses is carried out by identifying the control parameters and conducting the experimentation using L9 orthogonal array.

  13. Extending cluster lot quality assurance sampling designs for surveillance programs.

    Science.gov (United States)

    Hund, Lauren; Pagano, Marcello

    2014-07-20

    Lot quality assurance sampling (LQAS) has a long history of applications in industrial quality control. LQAS is frequently used for rapid surveillance in global health settings, with areas classified as poor or acceptable performance on the basis of the binary classification of an indicator. Historically, LQAS surveys have relied on simple random samples from the population; however, implementing two-stage cluster designs for surveillance sampling is often more cost-effective than simple random sampling. By applying survey sampling results to the binary classification procedure, we develop a simple and flexible nonparametric procedure to incorporate clustering effects into the LQAS sample design to appropriately inflate the sample size, accommodating finite numbers of clusters in the population when relevant. We use this framework to then discuss principled selection of survey design parameters in longitudinal surveillance programs. We apply this framework to design surveys to detect rises in malnutrition prevalence in nutrition surveillance programs in Kenya and South Sudan, accounting for clustering within villages. By combining historical information with data from previous surveys, we design surveys to detect spikes in the childhood malnutrition rate. Copyright © 2014 John Wiley & Sons, Ltd.

  14. A Digital Power Quality Monitoring Equipment Designed for Digital Substation

    Science.gov (United States)

    Li, Wei; Wang, Xin; Geng, Jiewen

    2018-01-01

    Taking into account both current status and development trend of digital substation, this paper proposed a design of a new multi-channelled digital power quality monitoring equipment with high compatibility. The overall functional structure, hardware architecture, software architecture, interface architecture and some key techniques such as IEC 61850 modelling of transient event and harmonic measurement method under the condition of non-synchronous sampling are described in this paper.

  15. Quality assurance in design: policy adopted by Vickers Barrow Engineering Works

    International Nuclear Information System (INIS)

    Aubrey, J.H.

    1976-01-01

    The quality assurance system operated by the Vickers Barrow Engineering Works is described, with special reference to the design of the reactor shield and above core structure for the first commercial fast reactor. Section headings are: introduction; what is quality assurance of design; attitude of designer; design discipline; customers attitude; Engineering Company system; future application of Design Quality Assurance Record system. (U.K.)

  16. Transforming nanomedicine manufacturing toward Quality by Design and microfluidics.

    Science.gov (United States)

    Colombo, Stefano; Beck-Broichsitter, Moritz; Bøtker, Johan Peter; Malmsten, Martin; Rantanen, Jukka; Bohr, Adam

    2018-04-05

    Nanopharmaceuticals aim at translating the unique features of nano-scale materials into therapeutic products and consequently their development relies critically on the progression in manufacturing technology to allow scalable processes complying with process economy and quality assurance. The relatively high failure rate in translational nanopharmaceutical research and development, with respect to new products on the market, is at least partly due to immature bottom-up manufacturing development and resulting sub-optimal control of quality attributes in nanopharmaceuticals. Recently, quality-oriented manufacturing of pharmaceuticals has undergone an unprecedented change toward process and product development interaction. In this context, Quality by Design (QbD) aims to integrate product and process development resulting in an increased number of product applications to regulatory agencies and stronger proprietary defense strategies of process-based products. Although QbD can be applied to essentially any production approach, microfluidic production offers particular opportunities for QbD-based manufacturing of nanopharmaceuticals. Microfluidics provides unique design flexibility, process control and parameter predictability, and also offers ample opportunities for modular production setups, allowing process feedback for continuously operating production and process control. The present review aims at outlining emerging opportunities in the synergistic implementation of QbD strategies and microfluidic production in contemporary development and manufacturing of nanopharmaceuticals. In doing so, aspects of design and development, but also technology management, are reviewed, as is the strategic role of these tools for aligning nanopharmaceutical innovation, development, and advanced industrialization in the broader pharmaceutical field. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. Lithography-induced limits to scaling of design quality

    Science.gov (United States)

    Kahng, Andrew B.

    2014-03-01

    Quality and value of an IC product are functions of power, performance, area, cost and reliability. The forthcoming 2013 ITRS roadmap observes that while manufacturers continue to enable potential Moore's Law scaling of layout densities, the "realizable" scaling in competitive products has for some years been significantly less. In this paper, we consider aspects of the question, "To what extent should this scaling gap be blamed on lithography?" Non-ideal scaling of layout densities has been attributed to (i) layout restrictions associated with multi-patterning technologies (SADP, LELE, LELELE), as well as (ii) various ground rule and layout style choices that stem from misalignment, reliability, variability, device architecture, and electrical performance vs. power constraints. Certain impacts seem obvious, e.g., loss of 2D flexibility and new line-end placement constraints with SADP, or algorithmically intractable layout stitching and mask coloring formulations with LELELE. However, these impacts may well be outweighed by weaknesses in design methodology and tooling. Arguably, the industry has entered a new era in which many new factors - (i) standard-cell library architecture, and layout guardbanding for automated place-and-route: (ii) performance model guardbanding and signoff analyses: (iii) physical design and manufacturing handoff algorithms spanning detailed placement and routing, stitching and RET; and (iv) reliability guardbanding - all contribute, hand in hand with lithography, to a newly-identified "design capability gap". How specific aspects of process and design enablements limit the scaling of design quality is a fundamental question whose answer must guide future RandD investment at the design-manufacturing interface. terface.

  18. Numerical determination of injector design for high beam quality

    International Nuclear Information System (INIS)

    Boyd, J.K.

    1985-01-01

    The performance of a free electron laser strongly depends on the electron beam quality or brightness. The electron beam is transported into the free electron laser after it has been accelerated to the desired energy. Typically the maximum beam brightness produced by an accelerator is constrained by the beam brightness deliverd by the accelerator injector. Thus it is important to design the accelerator injector to yield the required electron beam brightness. The DPC (Darwin Particle Code) computer code has been written to numerically model accelerator injectors. DPC solves for the transport of a beam from emission through acceleration up to the full energy of the injector. The relativistic force equation is solved to determine particle orbits. Field equations are solved for self consistent electric and magnetic fields in the Darwin approximation. DPC has been used to investigate the beam quality consequences of A-K gap, accelerating stress, electrode configuration and axial magnetic field profile

  19. Transforming nanomedicine manufacturing toward Quality by Design and microfluidics

    DEFF Research Database (Denmark)

    Colombo, Stefano; Beck-Broichsitter, Moritz; Bøtker, Johan Peter

    2018-01-01

    -oriented manufacturing of pharmaceuticals has undergone an unprecedented change toward process and product development interaction. In this context, Quality by Design (QbD) aims to integrate product and process development resulting in an increased number of product applications to regulatory agencies and stronger...... proprietary defense strategies of process-based products. Although QbD can be applied to essentially any production approach, microfluidic production offers particular opportunities for QbD-based manufacturing of nanopharmaceuticals. Microfluidics provides unique design flexibility, process control...... and parameter predictability, and also offers ample opportunities for modular production setups, allowing process feedback for continuously operating production and process control. The present review aims at outlining emerging opportunities in the synergistic implementation of QbD strategies and microfluidic...

  20. DESIGNING STRATEGIES FOR IMPROVING TOTAL QUALITY MANAGEMENT IN MANUFACTURING INDUSTRIES

    Directory of Open Access Journals (Sweden)

    Alfian Nur Ubay

    2017-05-01

    Full Text Available This research was aimed at designing strategies for improving total quality management at CV XYZ and PT HIJ. The research locations were selected intentionally with the consideration that the company is a middle class company that started to apply a study in line with the research topic. The experts were chosen using an approach method. This research used a descriptive approach and quantitative analysis through questionnaires using purposive sampling. The stages began with data processing, i.e. testing the questionnaire quality through validity and reliability tests, making a causality diagram, evaluating the implementation levels of each company by giving evaluation scales based on the existing condition, making House of Quality (HOQ using QFD methods, and then analyzing the problem solutions produced from the QFD methods with 5W + IH analysis, and finally determining the improvement priorities using Fuzzy AHP methods. The results were the strategies for improving total quality management /TQM of CV XYZ, namely the factor that plays the most important role was improving the quality management performance. The actor that has the competence to carry out the TQM improvement is the director. The prioritized goal to be achieved is a commitment to improve the quality of goods and services.  The prioritized strategy used in improving TQM is carrying out SOP consistently.Keywords: strategies, improvement, TQM, manufacturing company, fuzzy AHPABSTRAKPenelitian ini bertujuan merancang strategi peningkatan manajemen mutu terpadu pada CV XYZ dan PT HIJ. Pemilihan lokasi penelitian dilakukan secara sengaja dengan pertimbangan bahwa perusahaan tersebut merupakan perusahaan kelas menengah yang mulai menerapkan kajian sesuai dengan topik penelitian. Penentuan pakar dilakukan dengan metode pendekatan secara sengaja. Adapun penelitian ini menggunakan pendekatan deskriptif dan analisa kuantitatif dengan menyebarkan kuesioner secara sengaja (purposive sampling

  1. Identification and Reduction of Turbomachinery Noise, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Noise has become a primary consideration in the design and development of many products, particulary in aerospace, automotive and consumer product industries....

  2. Implementation of quality by design toward processing of food products.

    Science.gov (United States)

    Rathore, Anurag S; Kapoor, Gautam

    2017-05-28

    Quality by design (QbD) is a systematic approach that begins with predefined objectives and emphasizes product and process understanding and process control. It is an approach based on principles of sound science and quality risk management. As the food processing industry continues to embrace the idea of in-line, online, and/or at-line sensors and real-time characterization for process monitoring and control, the existing gaps with regard to our ability to monitor multiple parameters/variables associated with the manufacturing process will be alleviated over time. Investments made for development of tools and approaches that facilitate high-throughput analytical and process development, process analytical technology, design of experiments, risk analysis, knowledge management, and enhancement of process/product understanding would pave way for operational and economic benefits later in the commercialization process and across other product pipelines. This article aims to achieve two major objectives. First, to review the progress that has been made in the recent years on the topic of QbD implementation in processing of food products and second, present a case study that illustrates benefits of such QbD implementation.

  3. Design and quality control of an environmental data acquisition system

    International Nuclear Information System (INIS)

    FANJIRINDRATOVO, T.

    2009-01-01

    The present work is focused on the design of a microcontroller based measurement system and the control quality to validate it. So, a mobile instrument called DALENPA was designed to measure and log the following data: atmospheric pressure, ambient temperature, relative humidity, wind speed and direction, air dose rate, geographical coordinates by an embedded GPS receiver. The instrument is autonomous in energy by solar panel and can be connected to a PC directly or by modem. After, the quality control is based on the calibartion in a secondary laboratory. The target is to get its calibration curve and the estimation of global uncertainties. This estimation wants to include all sources of uncertainty belonging to the instrument and the secondary laboratory, and follows the method estabilished by the International Organization for Standardization (ISO) and the Bureau International des Poids et Mesures (BIPM). The calibration curve is fitted by the least squares method with uncertainties in the two variables. We got an efficient instrument with uncertainties under the limits estabilished by the regulating standards [fr

  4. Design, fabrication and quality assurance of pressure vessels

    International Nuclear Information System (INIS)

    Kimura, Ichiro; Miki, Masao; Yamazaki, Tsuneji; Tanaka, Yoshikazu; Sato, Misao

    1978-01-01

    The production facilities, design and manufacturing technologies, and quality assurance in the Toyo Works, Ehime Manufactory, Sumitomo Heavy Industries, Ltd., which manufactures pressure vessels, are described, and especially the actual example of non-destructive tests is shown. The Toyo Works was completed in April, 1973, to manufacture large structures such as pressure vessels, offshore structures and bridges. The total area of the site is 535,000 m 2 , that of factory buildings is 33,600 m 2 , and the outdoor assembling yard is 114,800 m 2 . The large dry dock and main installations such as 12,000 tf hydraulic press, an annealing furnace, a heat treating furnace, a quenching tank, a horizontal boring machine, 6 m vertical lathe, various welding machines, 8 MeV X-ray apparatus, sand blasting and pickling facilities, and two 160 t cranes for shipment are arranged so as to enable smooth flow of production. The standards for chemical pressure vessels in various countries are compared, and considerably high allowable stress is adopted in Europe. The design and stress analysis of pressure vessels are carried out in accordance with ASME Section 8, Div. 1 or Div. 2. As for the materials, attention must be paid to the change of properties due to heat and strain, temper brittleness, low temperature toughness and so on. The quality assurance system must be established to observe the requirements of standards. (Kako, I.)

  5. Quality improvement of melt extruded laminar systems using mixture design.

    Science.gov (United States)

    Hasa, D; Perissutti, B; Campisi, B; Grassi, M; Grabnar, I; Golob, S; Mian, M; Voinovich, D

    2015-07-30

    This study investigates the application of melt extrusion for the development of an oral retard formulation with a precise drug release over time. Since adjusting the formulation appears to be of the utmost importance in achieving the desired drug release patterns, different formulations of laminar extrudates were prepared according to the principles of Experimental Design, using a design for mixtures to assess the influence of formulation composition on the in vitro drug release from the extrudates after 1h and after 8h. The effect of each component on the two response variables was also studied. Ternary mixtures of theophylline (model drug), monohydrate lactose and microcrystalline wax (as thermoplastic binder) were extruded in a lab scale vertical ram extruder in absence of solvents at a temperature below the melting point of the binder (so that the crystalline state of the drug could be maintained), through a rectangular die to obtain suitable laminar systems. Thanks to the desirability approach and a reliability study for ensuring the quality of the formulation, a very restricted optimal zone was defined within the experimental domain. Among the mixture components, the variation of microcrystalline wax content played the most significant role in overall influence on the in vitro drug release. The formulation theophylline:lactose:wax, 57:14:29 (by weight), selected based on the desirability zone, was subsequently used for in vivo studies. The plasma profile, obtained after oral administration of the laminar extruded system in hard gelatine capsules, revealed the typical trend of an oral retard formulation. The application of the mixture experimental design associated to a desirability function permitted to optimize the extruded system and to determine the composition space that ensures final product quality. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Incorporating Servqual-QFD with Taguchi Design for optimizing service quality design

    Science.gov (United States)

    Arbi Hadiyat, M.

    2018-03-01

    Deploying good service design in service companies has been updated issue in improving customer satisfaction, especially based on the level of service quality measured by Parasuraman’s SERVQUAL. Many researchers have been proposing methods in designing the service, and some of them are based on engineering viewpoint, especially by implementing the QFD method or even using robust Taguchi method. The QFD method would found the qualitative solution by generating the “how’s”, while Taguchi method gives more quantitative calculation in optimizing best solution. However, incorporating both QFD and Taguchi has been done in this paper and yields better design process. The purposes of this research is to evaluate the incorporated methods by implemented it to a case study, then analyze the result and see the robustness of those methods to customer perception of service quality. Started by measuring service attributes using SERVQUAL and find the improvement with QFD, the deployment of QFD solution then generated by defining Taguchi factors levels and calculating the Signal-to-noise ratio in its orthogonal array, and optimized Taguchi response then found. A case study was given for designing service in local bank. Afterward, the service design obtained from previous analysis was then evaluated and shows that it was still meet the customer satisfaction. Incorporating QFD and Taguchi has performed well and can be adopted and developed for another research for evaluating the robustness of result.

  7. Hydrophobic polymers for orodispersible films: a quality by design approach.

    Science.gov (United States)

    Borges, Ana Filipa; Silva, Branca M A; Silva, Cláudia; Coelho, Jorge F J; Simões, Sérgio

    2016-10-01

    To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. A quality by design approach was applied to screen three different formulations each one based on a different hydrophobic polymer: polyvinyl acetate, methacrylate-based copolymer and shellac. The screening formulations were characterized regarding their mechanical properties, residual water content, disintegration time and appearance, in order to find a suitable ODF formulation according to established critical quality attributes. The selected critical process parameters for the selection of appropriate ODF formulations were the percentage of the different excipients and the plasticizer type. Three hydrophobic-based matrices with fast disintegration were developed. These were generically composed by a hydrophobic polymer, a stabilizer, a disintegrant and a plasticizer. It verified that the common components within the three different formulations behave differently depending on the system/chemical environment that they were included. It was shown that it is possible to develop oral films based on hydrophobic polymers with fast disintegration time, good texture and appearance, breaking a paradigm of the ODF research field.

  8. Software Design Improvements. Part 2; Software Quality and the Design and Inspection Process

    Science.gov (United States)

    Lalli, Vincent R.; Packard, Michael H.; Ziemianski, Tom

    1997-01-01

    The application of assurance engineering techniques improves the duration of failure-free performance of software. The totality of features and characteristics of a software product are what determine its ability to satisfy customer needs. Software in safety-critical systems is very important to NASA. We follow the System Safety Working Groups definition for system safety software as: 'The optimization of system safety in the design, development, use and maintenance of software and its integration with safety-critical systems in an operational environment. 'If it is not safe, say so' has become our motto. This paper goes over methods that have been used by NASA to make software design improvements by focusing on software quality and the design and inspection process.

  9. IMPROVING THE QUALITY OF INVESTMENT DESIGN IN INDUSTRIAL CONSTRUCTION

    Directory of Open Access Journals (Sweden)

    I. M. Meylanov

    2017-01-01

    Full Text Available Objectives. The development of a set of practical measures in order to improve the quality of investment design in industrial construction.Methods. The basis of research comprises a project management methodology as well as methods for logical and statistical analysis of decisionmaking in investment activities.Results. A mechanism of inclusion of industrial construction objects into the Federal targeted investment programme is revealed. The sequence of the state expert evaluation of investment projects is determined, which optimises the design solutions aimed at minimising their estimated cost if the investment is made with the involvement of the Federal budget. Qualitative and quantitative criteria are systematised for the integrated assessment of the effectiveness of investment fund usage sent to industrial construction objects.Conclusion. The consistent implementation of the state investment policy is aimed at developing the scientific-technological and scientific-industrial potential of industrial construction by providing favourable conditions for effective innovation activity, selecting rational investment strategies and priority projects aimed at solving urgent problems of improving the competitiveness of construction. Successful implementation of the state investment policy in industrial construction largely depends on the effectiveness of investment design, starting from the accuracy of the formulation of the investment plan (idea, in which the interests of all participants in investment activities are concentrated and taken into account, and to the development of an agreed set of actions to complete the project. A unified register covering the data on the cost and results of investment projects is proposed to be created with the purpose of facilitating decision-making in the process of allocation of the Federal budget funds, planning of state capital investments and approval of project documentation for new industrial construction

  10. Experimental design and quality assurance: in situ fluorescence instrumentation

    Science.gov (United States)

    Conmy, Robyn N.; Del Castillo, Carlos E.; Downing, Bryan D.; Chen, Robert F.

    2014-01-01

    Both instrument design and capabilities of fluorescence spectroscopy have greatly advanced over the last several decades. Advancements include solid-state excitation sources, integration of fiber optic technology, highly sensitive multichannel detectors, rapid-scan monochromators, sensitive spectral correction techniques, and improve data manipulation software (Christian et al., 1981, Lochmuller and Saavedra, 1986; Cabniss and Shuman, 1987; Lakowicz, 2006; Hudson et al., 2007). The cumulative effect of these improvements have pushed the limits and expanded the application of fluorescence techniques to numerous scientific research fields. One of the more powerful advancements is the ability to obtain in situ fluorescence measurements of natural waters (Moore, 1994). The development of submersible fluorescence instruments has been made possible by component miniaturization and power reduction including advances in light sources technologies (light-emitting diodes, xenon lamps, ultraviolet [UV] lasers) and the compatible integration of new optical instruments with various sampling platforms (Twardowski et at., 2005 and references therein). The development of robust field sensors skirt the need for cumbersome and or time-consuming filtration techniques, the potential artifacts associated with sample storage, and coarse sampling designs by increasing spatiotemporal resolution (Chen, 1999; Robinson and Glenn, 1999). The ability to obtain rapid, high-quality, highly sensitive measurements over steep gradients has revolutionized investigations of dissolved organic matter (DOM) optical properties, thereby enabling researchers to address novel biogeochemical questions regarding colored or chromophoric DOM (CDOM). This chapter is dedicated to the origin, design, calibration, and use of in situ field fluorometers. It will serve as a review of considerations to be accounted for during the operation of fluorescence field sensors and call attention to areas of concern when making

  11. Application of Absorption Modeling in Rational Design of Drug Product Under Quality-by-Design Paradigm.

    Science.gov (United States)

    Kesisoglou, Filippos; Mitra, Amitava

    2015-09-01

    Physiologically based absorption models can be an important tool in understanding product performance and hence implementation of Quality by Design (QbD) in drug product development. In this report, we show several case studies to demonstrate the potential application of absorption modeling in rational design of drug product under the QbD paradigm. The examples include application of absorption modeling—(1) prior to first-in-human studies to guide development of a formulation with minimal sensitivity to higher gastric pH and hence reduced interaction when co-administered with PPIs and/or H2RAs, (2) design of a controlled release formulation with optimal release rate to meet trough plasma concentrations and enable QD dosing, (3) understanding the impact of API particle size distribution on tablet bioavailability and guide formulation design in late-stage development, (4) assess impact of API phase change on product performance to guide specification setting, and (5) investigate the effect of dissolution rate changes on formulation bioperformance and enable appropriate specification setting. These case studies are meant to highlight the utility of physiologically based absorption modeling in gaining a thorough understanding of the product performance and the critical factors impacting performance to drive design of a robust drug product that would deliver the optimal benefit to the patients.

  12. Automated Theorem Proving in High-Quality Software Design

    Science.gov (United States)

    Schumann, Johann; Swanson, Keith (Technical Monitor)

    2001-01-01

    The amount and complexity of software developed during the last few years has increased tremendously. In particular, programs are being used more and more in embedded systems (from car-brakes to plant-control). Many of these applications are safety-relevant, i.e. a malfunction of hardware or software can cause severe damage or loss. Tremendous risks are typically present in the area of aviation, (nuclear) power plants or (chemical) plant control. Here, even small problems can lead to thousands of casualties and huge financial losses. Large financial risks also exist when computer systems are used in the area of telecommunication (telephone, electronic commerce) or space exploration. Computer applications in this area are not only subject to safety considerations, but also security issues are important. All these systems must be designed and developed to guarantee high quality with respect to safety and security. Even in an industrial setting which is (or at least should be) aware of the high requirements in Software Engineering, many incidents occur. For example, the Warshaw Airbus crash, was caused by an incomplete requirements specification. Uncontrolled reuse of an Ariane 4 software module was the reason for the Ariane 5 disaster. Some recent incidents in the telecommunication area, like illegal "cloning" of smart-cards of D2GSM handies, or the extraction of (secret) passwords from German T-online users show that also in this area serious flaws can happen. Due to the inherent complexity of computer systems, most authors claim that only a rigorous application of formal methods in all stages of the software life cycle can ensure high quality of the software and lead to real safe and secure systems. In this paper, we will have a look, in how far automated theorem proving can contribute to a more widespread application of formal methods and their tools, and what automated theorem provers (ATPs) must provide in order to be useful.

  13. Comparison of beam and shell theories for the vibrations of thin turbomachinery blades

    Science.gov (United States)

    Leissa, A. W.; Ewing, M. S.

    1982-01-01

    Vibration analysis of turbomachinery blades has traditionally been carried out by means of beam theory. In recent years two-dimensional methods of blade vibration analysis have been developed, most of which utilize finite elements and tend to require considerable computation time. More recently a two-dimensional method of blade analysis has evolved which does not require finite elements and is based upon shell equations. The present investigation has the primary objective to demonstrate the accuracy and limitations of blade vibration analyses which utilize one-dimensional, beam theories. It is found that beam theory is generally inadequate to determine the free vibration frequencies and mode shapes of moderate to low aspect ratio turbomachinery blades. The shallow shell theory, by contrast, is capable of representing all the vibration modes accurately. However, the one-dimensional beam theory has an important advantage over the two-dimensional shell theory for blades and vibration modes. It uses fewer degrees of freedom, thus requiring less computer time.

  14. A modular RANS approach for modelling laminar–turbulent transition in turbomachinery flows

    International Nuclear Information System (INIS)

    Liang Wang; Song Fu; Carnarius, Angelo; Mockett, Charles; Thiele, Frank

    2012-01-01

    Highlights: ► We propose a laminar–turbulent transition model for turbomachinery applications. ► The model considers the effects of the various instability modes. ► The pressure–diffusion process is represented by an elliptic formulation. ► The mixed-mode transition scenario benefits from our modular prediction approach. - Abstract: In this study we propose a laminar–turbulent transition model, which considers the effects of the various instability modes that exist in turbomachinery flows. This model is based on a K–ω–γ three-equation eddy-viscosity concept with K representing the fluctuating kinetic energy, ω the specific dissipation rate and γ the intermittency factor. As usual, the local mechanics by which the freestream disturbances penetrate into the laminar boundary layer, namely convection and viscous diffusion, are described by the transport equations. However, as a novel feature, the non-local effects due to pressure diffusion are additionally represented by an elliptic formulation. Such an approach allows the present model to respond accurately to freestream turbulence intensity properly and to predict both long and short bubble lengths well. The success in its application to a 3-D cascade indicates that the mixed-mode transition scenario indeed benefits from such a modular prediction approach, which embodies current conceptual understanding of the transition process.

  15. Optical surface contouring for non-destructive inspection of turbomachinery

    Science.gov (United States)

    Modarress, Dariush; Schaack, David F.

    1994-03-01

    Detection of stress cracks and other surface defects during maintenance and in-service inspection of propulsion system components, including turbine blades and combustion compartments, is presently performed visually. There is a need for a non-contact, miniaturized, and fully fieldable instrument that may be used as an automated inspection tool for inspection of aircraft engines. During this SBIR Phase 1 program, the feasibility of a ruggedized optical probe for automatic and nondestructive inspection of complex shaped objects will be established. Through a careful analysis of the measurement requirements, geometrical and optical constraints, and consideration of issues such as manufacturability, compactness, simplicity, and cost, one or more conceptual optical designs will be developed. The proposed concept will be further developed and a prototype will be fabricated during Phase 2.

  16. Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle.

    Science.gov (United States)

    Plowright, Alleyn T; Johnstone, Craig; Kihlberg, Jan; Pettersson, Jonas; Robb, Graeme; Thompson, Richard A

    2012-01-01

    In drug discovery, the central process of constructing and testing hypotheses, carefully conducting experiments and analysing the associated data for new findings and information is known as the design-make-test-analyse cycle. Each step relies heavily on the inputs and outputs of the other three components. In this article we report our efforts to improve and integrate all parts to enable smooth and rapid flow of high quality ideas. Key improvements include enhancing multi-disciplinary input into 'Design', increasing the use of knowledge and reducing cycle times in 'Make', providing parallel sets of relevant data within ten working days in 'Test' and maximising the learning in 'Analyse'. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Green design for productivity, health and quality of life

    Energy Technology Data Exchange (ETDEWEB)

    Hartkopf, V. [Carnegie Mellon Univ., Pittsburgh, PA (United States). Center for Building Performance and Diagnostics

    2005-07-01

    The potential cost-benefits for quality construction of office buildings were discussed with particular reference to sick building costs and health building gains. Cost-benefits were indicated in terms of first cost, operational energy costs, individual productivity, organizational productivity, health, attraction, taxation, and waste. The measures of human response in buildings were also discussed with reference to comfort and satisfaction, individual productivity, health and absenteeism, attraction, spatial flexibility, motivation and collaboration. The building attributes that have the greatest impact include air, light, thermal control, ergonomics, privacy and interaction, access to nature, land use and mobility. It was suggested that natural ventilation should be maximized with mixed-mode heating, ventilating and air conditioning (HVAC) systems, and that ventilation air should be separate from thermal conditioning. It was also suggested that temperature control can increase productivity and reduce energy consumption. Several international case studies have shown that acoustic privacy also increases individual productivity at complex tasks. The presentation concluded by indicating that healthy and sustainable design also depends on changing approaches to land use and community planning in terms of pedestrian walkways, maximized loading of infrastructure and buildings, minimized abandonment and green roof development to reduce annual cooling loads. tabs., figs.

  18. Curriculum and Course Design: A New Approach Using Quality Function Deployment

    Science.gov (United States)

    Denton, James W.; Kleist, Virginia Franke; Surendra, Nanda

    2005-01-01

    In this article, the authors describe a method for assuring the quality of curriculum design based on techniques that have been used in industrial settings for over 30 years. Quality Function Deployment assures that the needs of the customer are considered at all levels of product design and a graphical matrix called the House of Quality serves as…

  19. Quality assurance in design: policy adopted by Vickers Barrow Engineering Works

    International Nuclear Information System (INIS)

    Aubrey, J.H.

    1977-01-01

    The approach of the Engineering Company of the Shipbuilding Group to the establishment of design quality assurance is described. The introduction of a Design Quality Assurance Record (DQAR) is discussed and its manner of operation illustrated, taking a special pump design as an example. Future applications will include the shield and above-core structure of the first commercial fast reactor. (U.K.)

  20. A Quality Function Deployment (QFD approach to designing a prosthetic myoelectric hand

    Directory of Open Access Journals (Sweden)

    Erika Sofía Olaya Escobar

    2005-05-01

    Full Text Available This paper presents a Quality Function Deployment (QFD model based on computing with words. It is specifically used in the House of Quality (HOQ construction phase. It illustrates the methodology employed in designing a prosthetic myoelectric hand.

  1. A Quality Function Deployment (QFD) approach to designing a prosthetic myoelectric hand

    OpenAIRE

    Erika Sofía Olaya Escobar; Carlos Julio Cortés Rodríguez; Óscar Germán Duarte Velasco

    2005-01-01

    This paper presents a Quality Function Deployment (QFD) model based on computing with words. It is specifically used in the House of Quality (HOQ) construction phase. It illustrates the methodology employed in designing a prosthetic myoelectric hand.

  2. Selected parameters of moulding sands for designing quality control systems

    Directory of Open Access Journals (Sweden)

    J. Jakubski

    2010-07-01

    Full Text Available One of the modern methods of production optimisation are artificial neural networks. Neural networks owe their popularity to the fact thatthey are convenient tools, which can be utilised in a wide scope of problems. They are capable of reflecting complex functions. Especiallytheir non-linearity should be emphasised. They are gaining wider and wider application in the foundry industry, among others, to controlmelting processes in cupolas and arc furnaces, designing castings and supply systems, control of moulding sands treatments, prediction ofproperties of cast alloys as well as selecting die casting.An attempt of the application neural networks to the quality control of moulding sands with bentonite is presented in the paper. This isa method of assessing the suitability of moulding sands by finding correlations in between individual parameters, by means of artificialneural network systems. The presented investigations were performed with the application of the Statistica 8.0 program.The investigations were aimed at the selection of the proper kind of a neural network for prediction a sand moistness on the bases ofcertain moulding sand properties such as: permeability, compactibility and friability. These parameters – determined as sand moistness functions - were introduced as initial parameters.Application of the Statistica program allowed for an automatic selection of the most suitable network for the reflection of dependencies and interactions existing among the proposed parameters. The best results were obtained for unidirectional multi-layer perception network (MLP. The neural network sensitivity to individual moulding sand parameters was determined, which allowed to reject not important parameters when constructing the network.

  3. Designing and implementing a trust-wide quality assurance programme.

    Science.gov (United States)

    Coope, Sally-Ann

    2018-04-02

    Derbyshire Community Health Services (DCHS) NHS Foundation Trust provides a wide range of community-based health services. After the Care Quality Commission (CQC) found gaps in the trust's assurance process, its board decided to develop a method of continuous quality improvements that could be used as a basis for the trust's quality assurance system. The trust adapted and built on an acute model so it was suitable for community services. The final assurance system, Quality Always, has four elements: the clinical assessment and accreditation scheme; leadership development; 'champions' within clinical teams to support and promote the scheme; and dashboards to record and monitor progress. A system to recognise and reward achievement was essential for success. Quality Always has resulted in better care quality, an improved CQC rating, a sense of achievement among staff, the development of support networks, learning (especially among support staff) and good practice being shared.

  4. Environmental Monitoring, Water Quality - MO 2009 Water Quality Standards - Table G Lake Classifications and Use Designations (SHP)

    Data.gov (United States)

    NSGIC State | GIS Inventory — This data set contains Missouri Water Quality Standards (WQS) lake classifications and use designations described in the Missouri Code of State Regulations (CSR), 10...

  5. Monitoring drinking water quality in South Africa: Designing ...

    African Journals Online (AJOL)

    In South Africa, the management and monitoring of drinking water quality is governed by policies and regulations based on international standards. Water Service Authorities, which are either municipalities or district municipalities, are required to submit information regarding water quality and the management thereof ...

  6. Design Quality in the Context of Healthcare Environments: A Scoping Review.

    Science.gov (United States)

    Anåker, Anna; Heylighen, Ann; Nordin, Susanna; Elf, Marie

    2017-07-01

    We explored the concept of design quality in relation to healthcare environments. In addition, we present a taxonomy that illustrates the wide range of terms used in connection with design quality in healthcare. High-quality physical environments can promote health and well-being. Developments in healthcare technology and methodology put high demands on the design quality of care environments, coupled with increasing expectations and demands from patients and staff that care environments be person centered, welcoming, and accessible while also supporting privacy and security. In addition, there are demands that decisions about the design of healthcare architecture be based on the best available information from credible research and the evaluation of existing building projects. The basic principles of Arksey and O'Malley's model of scoping review design were used. Data were derived from literature searches in scientific databases. A total of 18 articles and books were found that referred to design quality in a healthcare context. Design quality of physical healthcare environments involves three different themes: (i) environmental sustainability and ecological values, (ii) social and cultural interactions and values, and (iii) resilience of the engineering and building construction. Design quality was clarified herein with a definition. Awareness of what is considered design quality in relation to healthcare architecture could help to design healthcare environments based on evidence. To operationalize the concept, its definition must be clear and explicit and able to meet the complex needs of the stakeholders in a healthcare context, including patients, staff, and significant others.

  7. Design and Establishment of Quality Model of Fundamental Geographic Information Database

    Science.gov (United States)

    Ma, W.; Zhang, J.; Zhao, Y.; Zhang, P.; Dang, Y.; Zhao, T.

    2018-04-01

    In order to make the quality evaluation for the Fundamental Geographic Information Databases(FGIDB) more comprehensive, objective and accurate, this paper studies and establishes a quality model of FGIDB, which formed by the standardization of database construction and quality control, the conformity of data set quality and the functionality of database management system, and also designs the overall principles, contents and methods of the quality evaluation for FGIDB, providing the basis and reference for carry out quality control and quality evaluation for FGIDB. This paper designs the quality elements, evaluation items and properties of the Fundamental Geographic Information Database gradually based on the quality model framework. Connected organically, these quality elements and evaluation items constitute the quality model of the Fundamental Geographic Information Database. This model is the foundation for the quality demand stipulation and quality evaluation of the Fundamental Geographic Information Database, and is of great significance on the quality assurance in the design and development stage, the demand formulation in the testing evaluation stage, and the standard system construction for quality evaluation technology of the Fundamental Geographic Information Database.

  8. Applying Quality Function Deployment in Industrial Design Curriculum Planning

    Science.gov (United States)

    Liu, Shuo-Fang; Lee, Yann-Long; Lin, Yi-Zhi; Tseng, Chien-Feng

    2013-01-01

    Industrial design is a discipline that combines multiple professional fields. Enterprise demands for industrial design competencies also change over time; thus, the curriculum of industrial design education should be compatible with the current demands of the industry. However, scientific approaches have not been previously employed to plan…

  9. Performance evaluation of turbomachinery in the petroleum exploration and production area

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Alisson Cardoso Gomes da [Petrobras Santos Basin Exploration and Production Operation Unit, Santos, SP (Brazil)], e-mail: alissoncardoso@petrobras.com.br; Oliveira Junior, Silvio de [State University of Sao Paulo, SP (Brazil). Mechanical Engineering Dept.], e-mail: soj@usp.br

    2010-07-01

    In light of the recent discoveries of new oil and natural gas reserves in the coast of Sao Paulo and Rio de Janeiro states, it will be required a large amount of investments for the development of hydrocarbons exploration and production. In this scenario, the turbomachinery play a crucial role because of its strong influence in the areas of power generation and ensuring the flow of current oil and natural gas produced in offshore platforms to the continent. Among the turbomachinery, it is possible to highlight gas turbines and centrifugal compressors, since they have high reliability, high thermodynamic efficiency and great operation and maintenance flexibility. However, gas turbines and centrifugal compressors show performance characteristics that distinctly depend on ambient and operating conditions. They are not only influenced by site elevation, ambient temperature and relative humidity, but also by the speed of the driven equipment, the fuel and the load conditions. Because of that, performance testing of gas turbines and compressors has become increasingly common due to the need to verify efficiency, power, fuel flow, capacity and head of the packages upon delivery. This paper suggests the use of seven performance parameters that generally describe the performance of a gas turbine and centrifugal compressor. Special consideration will be given to show a comprehensive view of the physical models and mathematical formulations required for evaluating this seven performance parameters based on the basic relationships of pressure, temperature, flow and head. Since the test conditions are rarely fully controlled, it will be discussed an approach to perform measurement uncertainties analysis, with the interest of assuring results validity. Finally, the paper present some considerations for conduct a proper performance evaluation test. (author)

  10. Advances in Ceramic Matrix Composite Blade Damping Characteristics for Aerospace Turbomachinery Applications

    Science.gov (United States)

    Min, James B.; Harris, Donald L.; Ting, J. M.

    2011-01-01

    For advanced aerospace propulsion systems, development of ceramic matrix composite integrally-bladed turbine disk technology is attractive for a number of reasons. The high strength-to-weight ratio of ceramic composites helps to reduce engine weight and the one-piece construction of a blisk will result in fewer parts count, which should translate into reduced operational costs. One shortcoming with blisk construction, however, is that blisks may be prone to high cycle fatigue due to their structural response to high vibration environments. Use of ceramic composites is expected to provide some internal damping to reduce the vibratory stresses encountered due to unsteady flow loads through the bladed turbine regions. A goal of our research was to characterize the vibration viscous damping behavior of C/SiC composites. The vibration damping properties were measured and calculated. Damping appeared to decrease with an increase in the natural frequency. While the critical damping amount of approximately 2% is required for typical aerospace turbomachinery engines, the C/SiC damping at high frequencies was less than 0.2% from our study. The advanced high-performance aerospace propulsion systems almost certainly will require even more damping than what current vehicles require. A purpose of this paper is to review some work on C/SiC vibration damping by the authors for the NASA CMC turbine blisk development program and address an importance of the further investigation of the blade vibration damping characteristics on candidate CMC materials for the NASA s advanced aerospace turbomachinery engine systems.

  11. Healthcare delivery systems: designing quality into health information systems.

    Science.gov (United States)

    Joyce, Phil; Green, Rosamund; Winch, Graham

    2007-01-01

    To ensure that quality is 'engineered in' a holistic, integrated and quality approach is required, and Total Quality Management (TQM) principles are the obvious foundations for this. This paper describes a novel approach to viewing the operations of a healthcare provider where electronic means could be used to distribute information (including electronic fund settlements), building around the Full Service Provider core. Specifically, an approach called the "triple pair flow" model is used to provide a view of healthcare delivery that is integrated, yet detailed, and that combines the strategic enterprise view with a business process view.

  12. The House of Quality: Using QFD for Instructional Design in Distance Education.

    Science.gov (United States)

    Murgatroyd, Stephen

    1993-01-01

    Examines the use of Quality Function Deployment (QFD) methods for the design, development, and delivery of courses and programs through distance education. Topics discussed include problems in implementing QFD; implementation of QFD in training design; and QFD's contribution to service quality improvement in distance education. (Contains 28…

  13. Logistics network design for perishable products with heterogeneous quality decay

    NARCIS (Netherlands)

    Keizer, de Marlies; Akkerman, Renzo; Grunow, Martin; Bloemhof-Ruwaard, Jacqueline; Haijema, Rene; Vorst, van der Jack G.A.J.

    2017-01-01

    The duration of logistics operations, as well as the environmental conditions during these operations, significantly impact the performance of a logistics network for fresh agricultural products. When durations or temperatures increase, product quality decreases and more effort is required to

  14. Beyond image quality : designing engaging interactions with digital products

    NARCIS (Netherlands)

    Ridder, de H.; Rozendaal, M.C.

    2008-01-01

    Ubiquitous computing (or Ambient Intelligence) promises a world in which information is available anytime anywhere and with which humans can interact in a natural, multimodal way. In such world, perceptual image quality remains an important criterion since most information will be displayed

  15. Beyond image quality : Designing engaging interactions with digital products

    NARCIS (Netherlands)

    De Ridder, H.; Rozendaal, M.C.

    2008-01-01

    Ubiquitous computing (or Ambient Intelligence) promises a world in which information is available anytime anywhere and with which humans can interact in a natural, multimodal way. In such world, perceptual image quality remains an important criterion since most information will be displayed

  16. Microfluidic chip designs process optimization and dimensional quality control

    DEFF Research Database (Denmark)

    Calaon, Matteo; Hansen, Hans Nørgaard; Tosello, Guido

    2015-01-01

    . Subsequent nickel electroplating was employed to replicate the obtained geometries on the tool, which was used to mold on transparent polymer substrates the functional structures. To assess the critical factors affecting the replication quality throughout the different steps of the proposed process chain...

  17. Evaluation of advanced turbomachinery for underground pumped hydroelectric storage. Part 3. Multistage unregulated pump/turbines for operating heads of 1000 to 1500 m

    Energy Technology Data Exchange (ETDEWEB)

    Frigo, A.A.; Pistner, C.

    1980-08-01

    This is the final report in a series of three on studies of advanced hydraulic turbomachinery for underground pumped hydroelectric storage. All three reports address Francis-type, reversible pump/turbines. The first report covered single-stage regulated units; the second report covered two-stage regulated units; the present report covers multistage unregulated units. Multistage unregulated pump/turbines offer an economically attractive option for heads of 1000 to 1500 m. The feasibility of developing such machines for capacities up to 500 MW and operating heads up to 1500 m has been evaluated. Preliminary designs have been generated for six multistage pump/turbines. The designs are for nominal capacities of 350 and 500 MW and for operating heads of 1000, 1250, and 1500 m. Mechanical, hydraulic, and economic analyses indicate that these machines will behave according to the criteria used to design them and that they can be built at a reasonable cost with no unsolvable problems. Efficiencies of 85.8% and 88.5% in the generating and pumping modes, respectively, can be expected for the 500-MW, 1500-m unit. Performances of the other five machines are at least comparable, and usually better. Over a 1000 to 1500-m head range, specific $/kW costs of the pump/turbines in mid-1978 US dollars vary from 19.0 to 23.1 for the 500-MW machines, and from 21.0 to 24.1 for the 350-MW machines.

  18. Resources for Indoor Air Quality Design Tools for Schools

    Science.gov (United States)

    The information available here is presented as a tool to help school districts and facility planners design the next generation of learning environments so that the school facility will help schools in achieving their core mission of educating children.

  19. Quality management in construction project design and management

    CSIR Research Space (South Africa)

    Conradie, Dirk CU

    2008-03-01

    Full Text Available (1991), being an artificial intelligence researcher, thought that this indicated that creative designs should be generated from experience such as the use of Case-based Reasoning (CBR) and not deductive rules. • Problems may be barely decomposable.... It is sometimes possible to break problems down into smaller sub problems. However, these sub problems tend to be highly inter- constrained. Researchers in the Artificial Intelligence field of CBR thought that this indicated that new designs should be based...

  20. Economic evaluation of flying-qualities design criteria for a transport configured with relaxed static stability

    Science.gov (United States)

    Sliwa, S. M.

    1980-01-01

    Direct constrained parameter optimization was used to optimally size a medium range transport for minimum direct operating cost. Several stability and control constraints were varied to study the sensitivity of the configuration to specifying the unaugmented flying qualities of transports designed to take maximum advantage of relaxed static stability augmentation systems. Additionally, a number of handling qualities related design constants were studied with respect to their impact on the design.

  1. Co-designing for quality: Creating a user-driven tool to improve quality in youth mental health services.

    Science.gov (United States)

    Hackett, Christina L; Mulvale, Gillian; Miatello, Ashleigh

    2018-04-29

    Although high quality mental health care for children and youth is a goal of many health systems, little is known about the dimensions of quality mental health care from users' perspectives. We engaged young people, caregivers and service providers to share experiences, which shed light on quality dimensions for youth mental health care. Using experience-based co-design, we collected qualitative data from young people aged 16-24 with a mental disorder (n = 19), identified caregivers (n = 12) and service providers (n = 14) about their experiences with respect to youth mental health services. Experience data were collected using multiple approaches including interviews, a suite of online and smartphone applications (n = 22), and a co-design event (n = 16) and analysed to extract touch points. These touch points were used to prioritize and co-design a user-driven prototype of a questionnaire to provide feedback to service providers. Young people, caregiver and service provider reports of service experiences were used to identify aspects of care quality at eight mental health service contact points: Access to mental health care; Transfer to/from hospital; Intake into hospital; Services provided; Assessment and treatment; Treatment environment; and Caregiver involvement in care. In some cases, low quality care was harmful to users and their caregivers. Young people co-designed a prototype of a user-driven feedback questionnaire to improve quality of service experiences that was supported by service providers and caregivers at the co-design event. By using EBCD to capture in-depth data regarding experiences of young people, their caregivers and service providers, study participants have begun to establish a baseline for acceptable quality of mental health care for young people. © 2018 The Authors. Health Expectations published by John Wiley & Sons Ltd.

  2. The relationship between building design and residents' quality of life in extra care housing schemes.

    Science.gov (United States)

    Orrell, Alison; McKee, Kevin; Torrington, Judith; Barnes, Sarah; Darton, Robin; Netten, Ann; Lewis, Alan

    2013-05-01

    Well-designed housing is recognised as being an important factor in promoting a good quality of life. Specialised housing models incorporating care services, such as extra care housing (ECH) schemes are seen as enabling older people to maintain a good quality of life despite increasing health problems that can accompany ageing. Despite the variation in ECH building design little is known about the impact of ECH building design on the quality of life of building users. The evaluation of older people's living environments (EVOLVE) study collected cross-sectional data on building design and quality of life in 23 ECH schemes in England, UK. Residents' quality of life was assessed using the schedule for the evaluation of individual quality of life-direct weighting (SEIQoL-DW) and on the four domains of control, autonomy, self-realisation and pleasure on the CASP-19. Building design was measured on 12 user-related domains by means of a new tool; the EVOLVE tool. Using multilevel linear regression, significant associations were found between several aspects of building design and quality of life. Furthermore, there was evidence that the relationship between building design and quality of life was partly mediated by the dependency of participants and scheme size (number of living units). Our findings suggest that good quality building design in ECH can support the quality of life of residents, but that designing features that support the needs of both relatively independent and frail users is problematic, with the needs of highly dependent users not currently supported as well as could be hoped by ECH schemes. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. IN QUEST OF TOTAL QUALITY MANAGEMENT PRINCIPLES IN ARCHITECTURAL DESIGN SERVICES: EVIDENCE FROM TURKEY

    Directory of Open Access Journals (Sweden)

    Umut Durmus

    2010-12-01

    Full Text Available Proposal: Architectural design companies increasingly recognize that time spent on management is not at the expense of their production and there are always better ways to organize business. Although architects have long placed a traditional emphasis on quality, quality management is still a new concept for the majority of architectural design companies, which have to organize relatively more complicated operations nowadays to meet their clients’ expectations. This study aims to understand how architectural design companies define quality and explores the extent to which Total Quality Management (TQM principles like continual improvement, employee involvement, customer satisfaction and others can be pertinent in these companies. Adopting a qualitative research strategy, the authors interviewed with the owner-managers of 10 widely-recognized architectural design companies of different size in Istanbul. The results from the content analysis of semi-structured interview data suggest that i TQM principles cannot be directly applied in architectural design companies without an appropriate translation; ii special characteristics of design services are important to explain quality-related perceptions of owner-managers; iii the owner-managers feel the pressure from the changing internal and external environmental conditions, however few of them adopt a systematic and documented approach to quality management. Architectural design offices which aim to establish a quality management system can benefit from this study to understand potential problem areas on their road.

  4. Pharmaceutical quality by design: product and process development, understanding, and control.

    Science.gov (United States)

    Yu, Lawrence X

    2008-04-01

    The purpose of this paper is to discuss the pharmaceutical Quality by Design (QbD) and describe how it can be used to ensure pharmaceutical quality. The QbD was described and some of its elements identified. Process parameters and quality attributes were identified for each unit operation during manufacture of solid oral dosage forms. The use of QbD was contrasted with the evaluation of product quality by testing alone. The QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include: Defining target product quality profile; Designing product and manufacturing processes; Identifying critical quality attributes, process parameters, and sources of variability; Controlling manufacturing processes to produce consistent quality over time. Using QbD, pharmaceutical quality is assured by understanding and controlling formulation and manufacturing variables. Product testing confirms the product quality. Implementation of QbD will enable transformation of the chemistry, manufacturing, and controls (CMC) review of abbreviated new drug applications (ANDAs) into a science-based pharmaceutical quality assessment.

  5. Quality-driven methodology for demanding accelarator design

    NARCIS (Netherlands)

    Jozwiak, L.; Jan, Y.

    2010-01-01

    This paper focuses on mastering the architecture development of hardware accelerators for demanding applications. It presents the results of our analysis of the main problems that have to be solved when designing accelerators for modern demanding applications, and illustrates the problems with an

  6. Facility design consequences of different employees’ quality perceptions

    NARCIS (Netherlands)

    Kok, Herman; Mobach, Mark P.; Omta, Onno

    2015-01-01

    An important challenge for facility management is to integrate the complex and comprehensive construct of different service processes and physical elements of the service facility into a meaningful and functional facility design. The difficulty of this task is clearly indicated by the present study

  7. design innovations towards enhancing the quality of living in multi ...

    African Journals Online (AJOL)

    Prince Acheampong

    1Department of Architecture, Faculty of Architecture and Building Technology. 2Institute of ... The compound house is one of the most versatile housing designs that most low-income households presently enjoy in ... Since the compound housing principle is more towards communal living and the sharing of facilities, these.

  8. A Model for Quality Optimization in Software Design Processes

    NARCIS (Netherlands)

    Noppen, J.A.R.; van den Broek, P.M.; Aksit, Mehmet

    The main objective of software engineers is to design and implement systems that implement all functional and non-functional requirements. Unfortunately, it is very difficult or even generally impossible to deliver a software system that satisfies all the requirements. Even more seriously, failures

  9. Process understanding and cooperative design. Keys to high quality automation

    International Nuclear Information System (INIS)

    Tommila, T.; Heinonen, R.

    1995-01-01

    A systematic approach to the specification of process control systems, and four practical methods supporting user participation and interdisciplinary co-operation are described. The main steps of the design approach are: (1) hierarchical decomposition of the plant to process items of different types; (2) analysis and definition of requirements and control strategies associated with each process item; (3) definition of automation degree; and (4) functional specification of the control system and its user interface. The specification language used for this step is a combination of principles found in object oriented design, structured analysis as well as new language standards for programmable controllers and open information systems. The design review methods presented include structured control strategy meetings, safety analysis of sequential controls, review of graphic displays, and a usability questionnaire for existing plants. These methods can be used to elicit users' needs and operational experience, to gain a common understanding of the process functionality, or to detect errors in design specifications or in existing systems. (8 refs., 9 figs.)

  10. The SPS Beam quality monitor, from design to operation

    CERN Document Server

    Papotti, G; Follin, F; Shaposhnikova, E

    2011-01-01

    The SPS Beam Quality Monitor is a system that monitors longitudinal beam parameters on a cycle-by-cycle basis and prevents extraction to the LHC in case the specifications are not met. This avoids losses, unnecessary stress of machine protection components and luminosity degradation, additionally helping efficiency during the filling process. The system has been operational since the 2009 LHC run, checking the beam pattern, its correct position with respect to the LHC references, individual bunch lengths and stability. In this paper the algorithms used, the hardware implementation and the operational aspects are presented.

  11. Forward-Oriented Designing for Learning as a Means to Achieve Educational Quality

    Science.gov (United States)

    Ghislandi, Patrizia M. M.; Raffaghelli, Juliana E.

    2015-01-01

    In this paper, we reflect on how Design for Learning can create the basis for a culture of educational quality. We explore the process of Design for Learning within a blended, undergraduate university course through a teacher-led inquiry approach, aiming at showing the connections between the process of Design for Learning and academic…

  12. Design of agricultural product quality safety retrospective supervision system of Jiangsu province

    Science.gov (United States)

    Wang, Kun

    2017-08-01

    In store and supermarkets to consumers can trace back agricultural products through the electronic province card to query their origin, planting, processing, packaging, testing and other important information and found that the problems. Quality and safety issues can identify the responsibility of the problem. This paper designs a retroactive supervision system for the quality and safety of agricultural products in Jiangsu Province. Based on the analysis of agricultural production and business process, the goal of Jiangsu agricultural product quality safety traceability system construction is established, and the specific functional requirements and non-functioning requirements of the retroactive system are analyzed, and the target is specified for the specific construction of the retroactive system. The design of the quality and safety traceability system in Jiangsu province contains the design of the overall design, the trace code design and the system function module.

  13. Minnowbrook IV: 2003 Workshop on Transition and Unsteady Aspects of Turbomachinery Flows

    Science.gov (United States)

    LaGraff, John E. (Editor); Ashpis, David E.

    2004-01-01

    This Minnowbrook IV 2003 workshop on Transition and Unsteady Aspects of Turbomachinery Flows includes the following topics: 1) Current Issues in Unsteady Turbomachinery Flows; 2) Global Instability and Control of Low-Pressure Turbine Flows; 3) Influence of End Wall Leakage on Secondary Flow Development in Axial Turbines; 4) Active and Passive Flow Control on Low Pressure Turbine Airfoils; 5) Experimental and Numerical Investigation of Transitional Flows as Affected by Passing Wakes; 6) Effects of Freestream Turbulence on Turbine Blade Heat Transfer; 7) Bypass Transition Via Continuous Modes and Unsteady Effects on Film Cooling; 8) High Frequency Surface Heat Flux Imaging of Bypass Transition; 9) Skin Friction and Heat Flux Oscillations in Upstream Moving Wave Packets; 10) Transition Mechanisms and Use of Surface Roughness to Enhance the Benefits of Wake Passing in LP Turbines; 11) Transient Growth Approach to Roughness-Induced Transition; 12) Roughness- and Freestream-Turbulence-Induced Transient Growth as a Bypass Transition Mechanism; 13) Receptivity Calculations as a Means to Predicting Transition; 14) On Streamwise Vortices in a Curved Wall Jet and Their Effect on the Mean Flow; 15) Plasma Actuators for Separation Control of Low Pressure Turbine Blades; 16) Boundary-Layer Separation Control Under Low-Pressure-Turbine Conditions Using Glow-Discharge Plasma Actuators; 17) Control of Separation for Low Pressure Turbine Blades: Numerical Simulation; 18) Effects of Elevated Free-Stream Turbulence on Active Control of a Separation Bubble; 19) Wakes, Calming and Transition Under Strong Adverse Pressure Gradients; 20) Transitional Bubble in Periodic Flow Phase Shift; 21) Modelling Spots: The Calmed Region, Pressure Gradient Effects and Background; 22) Modeling of Unsteady Transitional Flow on Axial Compressor Blades; 23) Challenges in Predicting Component Efficiencies in Turbomachines With Low Reynolds Number Blading; 24) Observations on the Causal Relationship Between

  14. Design of a Secure System Considering Quality of Service

    Directory of Open Access Journals (Sweden)

    Seondong Heo

    2014-11-01

    Full Text Available Improvements in networking technologies have provided users with useful information services. Such information services may bring convenience and efficiency, but might be accompanied by vulnerabilities to a variety of attacks. Therefore, a variety of research to enhance the security of the systems and get the services at the same time has been carried out. Especially, research on intrusion-tolerant systems (ITSs has been conducted in order to survive against every intrusion, rather than to detect and prevent them. In this paper, an ITS based on effective resource conversion (ERC is presented to achieve the goal of intrusion-tolerance. Instead of using the fixed number of virtual machines (VMs to process requests and recover as in conventional approaches, the ITS based on ERC can transform the assigned resources depending on the system status. This scheme is proved to maintain a certain level of quality of service (QoS and quality of security service (QoSS in threatening environments. The performance of ERC is compared with previous studies on ITS by CSIM 20, and it is verified that the proposed scheme is more effective in retaining a specific level of QoS and QoSS.

  15. Surface quality finish in laser cutting using Taguchi design

    Czech Academy of Sciences Publication Activity Database

    Sharma, V.; Chattopadhyaya, S.; Hloch, Sergej

    2017-01-01

    Roč. 24, č. 1 (2017), s. 15-19 ISSN 1330-3651 Institutional support: RVO:68145535 Keywords : cutting speed * factorial design * laser pulse width * orthogonal array * pulse repetition rate (PRR) or pulse frequency Subject RIV: JQ - Machines ; Tools OBOR OECD: Mechanical engineering Impact factor: 0.723, year: 2016 http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=257818

  16. Handling Quality Requirements for Advanced Aircraft Design: Longitudinal Mode

    Science.gov (United States)

    1979-08-01

    true integracion of a variety of subsystems. The motivation for digital control is simply stated: expensive hardware-intensive control logic and...control. The discussions of system: "architecture" (bus structure, single vs multiple central processing units (CPUs), input/output design, etc.) are...more complex than multiplication by’a constant. This would occur, for example, if one * 22 4 .. -. wished to mechanize a pitch damper. How does one

  17. Taguchi Approach to Design Optimization for Quality and Cost: An Overview

    Science.gov (United States)

    Unal, Resit; Dean, Edwin B.

    1990-01-01

    Calibrations to existing cost of doing business in space indicate that to establish human presence on the Moon and Mars with the Space Exploration Initiative (SEI) will require resources, felt by many, to be more than the national budget can afford. In order for SEI to succeed, we must actually design and build space systems at lower cost this time, even with tremendous increases in quality and performance requirements, such as extremely high reliability. This implies that both government and industry must change the way they do business. Therefore, new philosophy and technology must be employed to design and produce reliable, high quality space systems at low cost. In recognizing the need to reduce cost and improve quality and productivity, Department of Defense (DoD) and National Aeronautics and Space Administration (NASA) have initiated Total Quality Management (TQM). TQM is a revolutionary management strategy in quality assurance and cost reduction. TQM requires complete management commitment, employee involvement, and use of statistical tools. The quality engineering methods of Dr. Taguchi, employing design of experiments (DOE), is one of the most important statistical tools of TQM for designing high quality systems at reduced cost. Taguchi methods provide an efficient and systematic way to optimize designs for performance, quality, and cost. Taguchi methods have been used successfully in Japan and the United States in designing reliable, high quality products at low cost in such areas as automobiles and consumer electronics. However, these methods are just beginning to see application in the aerospace industry. The purpose of this paper is to present an overview of the Taguchi methods for improving quality and reducing cost, describe the current state of applications and its role in identifying cost sensitive design parameters.

  18. Analytical quality by design: a tool for regulatory flexibility and robust analytics.

    Science.gov (United States)

    Peraman, Ramalingam; Bhadraya, Kalva; Padmanabha Reddy, Yiragamreddy

    2015-01-01

    Very recently, Food and Drug Administration (FDA) has approved a few new drug applications (NDA) with regulatory flexibility for quality by design (QbD) based analytical approach. The concept of QbD applied to analytical method development is known now as AQbD (analytical quality by design). It allows the analytical method for movement within method operable design region (MODR). Unlike current methods, analytical method developed using analytical quality by design (AQbD) approach reduces the number of out-of-trend (OOT) results and out-of-specification (OOS) results due to the robustness of the method within the region. It is a current trend among pharmaceutical industry to implement analytical quality by design (AQbD) in method development process as a part of risk management, pharmaceutical development, and pharmaceutical quality system (ICH Q10). Owing to the lack explanatory reviews, this paper has been communicated to discuss different views of analytical scientists about implementation of AQbD in pharmaceutical quality system and also to correlate with product quality by design and pharmaceutical analytical technology (PAT).

  19. The OA System of College - - Design of the Teaching Quality Monitoring Subsystem

    Science.gov (United States)

    Wu, Hongjuan; Ying, Hong; Jiang, Youyi; Yan, Pei

    According to the drawbacks of traditional teaching quality monitoring subsystems and based on the achievements of practical research in the teaching quality monitoring administration in College, this paper provides a design of overall structure of teaching quality monitoring subsystem, that is more suitable for colleges' management. This new system is endowed with the same features as .NET application programes: easy to extend, easy to maintain, flexible, convenient, and it let enterprises, students' parents and excellent graduates participate in teaching quality monitoring administration, have significant effect to ensure the quality of talent training in colleges.

  20. Packaging design as an implicit communicator : Effects on product quality inferences in the presence of explicit quality cues

    NARCIS (Netherlands)

    van Ooijen, Iris; Fransen, Marieke L; Verlegh, Peeter W.J.; Smit, Edith G

    2017-01-01

    In this work we examine the interactive effect of packaging design and explicit packaging cues on quality inferences. Although the effect of explicit cues on product perception has been studied extensively, systematic research on this topic is still in its infancy. Furthermore, it has never been

  1. Quality system target on a detail design activity irradiator ISG 500

    International Nuclear Information System (INIS)

    Reinhard Pardede

    2010-01-01

    Currently, an engineering team of Nuclear Equipment Engineering Center PRPN has been beening technology innovation detail design of Irradiator ISG 500, then enter continuing to a construction phase. A schedule detail design still being not finish yet. The installation of Irradiator ISG 500 will be used to preservative the result of agricultural product in Indonesia. It is known as an export commodity and row material for food. However, its quality need some improvements in order to meet internal and foreign consumer standard. To enhance a quality system in detail design phase has already used ISO 9001: 2008 on clausul-7: Product Realization-design. It also needs a radioactive regulation Bapeten-Indonesian Nuclear Energy Surveillance Agency compliance with IAEA GS-R 3: 2006 as well. Scope of activity design is Instrumentation and Control system; Mechanical- Electrical; Radiation and Safety and Dosimetry; Civil Structured; Quality Assurance and Technoeconomic. Technology Innovating be applied to achieved economics through Costumer and Market Focused. Gamma irradiation of Irradiator ISG 500 can be used to improve hygienic quality in terms of technological as well as economical aspects. Technology innovation fit with the state of the arts right now. Assessment should be done base not only internal audit but also monitoring and surveillance as well. By application of a Quality System on detail design activity hopefully to enhance quality on detail design, construction, more over irradiator operation. (author)

  2. Design of Interline Unified Power Quality Conditioner for Power Quality Disturbances using Simulink

    Science.gov (United States)

    Kumaraswamy, G.; Reddy, Y. Rajasekhar; Harikrishna, Ch.

    2012-10-01

    Proliferation of electronic equipment in commercial and industrial processes has resulted in increasingly sensitive electrical loads to be fed from power distribution system which introduce contamination to voltage and current waveforms at the point of common coupling of industrial loads. The unified power quality conditioner (UPQC) is connected between two different feeders (lines), hence this method of connection of the UPQC is called as Interline UPQC (IUPQC).This paper proposes a new connection for a UPQC to improve the power quality of two feeders in a distribution system. Interline Unified Power Quality Conditioner (IUPQC), specifically aims at the integration of series VSC and Shunt VSC to provide high quality power supply by means of voltage sag/swell compensation, harmonic elimination and power factor correction in a power distribution network, so that improved power quality can be made available at the point of common coupling. The structure, control and capability of the IUPQC are discussed in this paper. The efficiency of the proposed configuration has been verified through simulation using MATLAB/ SIMULINK.

  3. Design of High Quality Chemical XOR Gates with Noise Reduction.

    Science.gov (United States)

    Wood, Mackenna L; Domanskyi, Sergii; Privman, Vladimir

    2017-07-05

    We describe a chemical XOR gate design that realizes gate-response function with filtering properties. Such gate-response function is flat (has small gradients) at and in the vicinity of all the four binary-input logic points, resulting in analog noise suppression. The gate functioning involves cross-reaction of the inputs represented by pairs of chemicals to produce a practically zero output when both are present and nearly equal. This cross-reaction processing step is also designed to result in filtering at low output intensities by canceling out the inputs if one of the latter has low intensity compared with the other. The remaining inputs, which were not reacted away, are processed to produce the output XOR signal by chemical steps that result in filtering at large output signal intensities. We analyze the tradeoff resulting from filtering, which involves loss of signal intensity. We also discuss practical aspects of realizations of such XOR gates. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Quality Designed Twin Wire Arc Spraying of Aluminum Bores

    Science.gov (United States)

    König, Johannes; Lahres, Michael; Methner, Oliver

    2015-01-01

    After 125 years of development in combustion engines, the attractiveness of these powerplants still gains a great deal of attention. The efficiency of engines has been increased continuously through numerous innovations during the last years. Especially in the field of motor engineering, consequent friction optimization leads to cost-effective fuel consumption advantages and a CO2 reduction. This is the motivation and adjusting lever of NANOSLIDE® from Mercedes-Benz. The twin wire arc-spraying process of the aluminum bore creates a thin, iron-carbon-alloyed coating which is surface-finished through honing. Due to the continuous development in engines, the coating strategies must be adapted in parallel to achieve a quality-conformed coating result. The most important factors to this end are the controlled indemnification of a minimal coating thickness and a homogeneous coating deposition of the complete bore. A specific system enables the measuring and adjusting of the part and the central plunging of the coating torch into the bore to achieve a homogeneous coating thickness. Before and after measurement of the bore diameter enables conclusions about the coating thickness. A software tool specifically developed for coating deposition can transfer this information to a model that predicts the coating deposition as a function of the coating strategy.

  5. Mechanism Design for Task Procurement with Flexible Quality of Service

    Science.gov (United States)

    Gerding, Enrico H.; Larson, Kate; Rogers, Alex; Jennings, Nicholas R.

    In this paper, we consider the problem where an agent wishes to complete a single computational task, but lacks the required resources. Instead, it must contract self-interested service providers, who are able to flexibly manipulate the quality of service they deliver, in order to maximise their own utility. We extend an existing model to allow for multiple such service providers to be contracted for the same task, and derive optimal task procurement mechanisms in the setting where the agent has full knowledge of the cost functions of these service providers (considering both simultaneous and sequential procurement). We then extend these results to the incomplete information setting where the agent must elicit cost information from the service providers, and we characterise a family of incentive-compatible and individually-rational mechanisms. We show empirically that sequential procurement always generates greater utility for the agent compared to simultaneous procurement, and that over a range of settings, contracting multiple providers is preferable to contracting just one.

  6. Research on knowledge support technology for product innovation design based on quality function knowledge deployment

    Directory of Open Access Journals (Sweden)

    Kai Zhang

    2016-06-01

    Full Text Available Based on the analysis of the relationship between the process of product innovation design and knowledge, this article proposes a theoretical model of quality function knowledge deployment. In order to link up the product innovation design and the knowledge required by the designer, the iterative method of quality function knowledge deployment is refined, as well as the knowledge retrieval model and knowledge support model based on quality function knowledge deployment are established. In the whole life cycle of product design, in view of the different requirements for knowledge in conceptual design stage, components’ configuration stage, process planning stage, and production planning stage, the quality function knowledge deployment model could link up the required knowledge with the engineering characteristics, component characteristics, process characteristics, and production characteristics in the four stages using the mapping relationship between the function characteristics and the knowledge and help the designer to track the required knowledge for realizing product innovation design. In this article, an instance about rewinding machine is given to demonstrate the practicability and validity of product innovation design knowledge support technology based on quality function knowledge deployment.

  7. Quality assurance program requirements (design and construction). Task RS 002-5. Revision 3

    International Nuclear Information System (INIS)

    1985-08-01

    This regulatory guide describes a method acceptable to the NRC staff for complying with regard to establishing and implementing the requisite quality assurance program for the design and construction of nuclear power plants. Guidance for the establishment and execution of quality assurance programs during operation and decommissioning of nuclear power plants have been or will be addressed in separate regulatory guides. Similarly, quality assurance provisions concerning fuel cycle facilities have been or will be addressed in separate regulatory guides

  8. Quality control of the structural design of Angra 2 and 3 power reactor

    International Nuclear Information System (INIS)

    Merino, J.L.E.; Carvalho, S.R.B. de

    1985-01-01

    The quality control requirements for nuclear power plants are done by CNEN and might be followed by the organizations that are responsible for those activities, such as: design, suppliers, construction, fabrication, mounting, installation, commissioning, operation, maintenance, modification and decommissioning. The Promon's experience for using a quality control program in the structural design of Angra 2 and 3, and the verification system adopted, are presented. (E.G.) [pt

  9. Applying Quality Indicators to Single-Case Research Designs Used in Special Education: A Systematic Review

    Science.gov (United States)

    Moeller, Jeremy D.; Dattilo, John; Rusch, Frank

    2015-01-01

    This study examined how specific guidelines and heuristics have been used to identify methodological rigor associated with single-case research designs based on quality indicators developed by Horner et al. Specifically, this article describes how literature reviews have applied Horner et al.'s quality indicators and evidence-based criteria.…

  10. 75 FR 78952 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2010-12-17

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants; Commonwealth of Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator (HMIWI) Units, Negative... Quality, 629 East Main Street, Richmond, Virginia 23219. FOR FURTHER INFORMATION CONTACT: James B. Topsale...

  11. 75 FR 78916 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2010-12-17

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants, Commonwealth of Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator (HMIWI) Units, Negative... 19103. Copies of the State submittal are available at the Virginia Department of Environmental Quality...

  12. Quality Market: Design and Field Study of Prediction Market for Software Quality Control

    Science.gov (United States)

    Krishnamurthy, Janaki

    2010-01-01

    Given the increasing competition in the software industry and the critical consequences of software errors, it has become important for companies to achieve high levels of software quality. While cost reduction and timeliness of projects continue to be important measures, software companies are placing increasing attention on identifying the user…

  13. Taguchi experimental design to determine the taste quality characteristic of candied carrot

    Science.gov (United States)

    Ekawati, Y.; Hapsari, A. A.

    2018-03-01

    Robust parameter design is used to design product that is robust to noise factors so the product’s performance fits the target and delivers a better quality. In the process of designing and developing the innovative product of candied carrot, robust parameter design is carried out using Taguchi Method. The method is used to determine an optimal quality design. The optimal quality design is based on the process and the composition of product ingredients that are in accordance with consumer needs and requirements. According to the identification of consumer needs from the previous research, quality dimensions that need to be assessed are the taste and texture of the product. The quality dimension assessed in this research is limited to the taste dimension. Organoleptic testing is used for this assessment, specifically hedonic testing that makes assessment based on consumer preferences. The data processing uses mean and signal to noise ratio calculation and optimal level setting to determine the optimal process/composition of product ingredients. The optimal value is analyzed using confirmation experiments to prove that proposed product match consumer needs and requirements. The result of this research is identification of factors that affect the product taste and the optimal quality of product according to Taguchi Method.

  14. elsA-Hybrid: an all-in-one structured/unstructured solver for the simulation of internal and external flows. Application to turbomachinery

    Science.gov (United States)

    de la Llave Plata, M.; Couaillier, V.; Le Pape, M.-C.; Marmignon, C.; Gazaix, M.

    2013-03-01

    This paper reports recent work on the extension of the multiblock structured solver elsA to deal with hybrid grids. The new hybrid-grid solver is called elsA-H (elsA-Hybrid), is based on the investigation of a new unstructured-grid module has been built within the original elsA CFD (computational fluid dynamics) system. The implementation benefits from the flexibility of the object-oriented design. The aim of elsA-H is to take advantage of the full potential of structured solvers and unstructured mesh generation by allowing any type of grid to be used within the same simulation process. The main challenge lies in the numerical treatment of the hybrid-grid interfaces where blocks of different type meet. In particular, one must pay attention to the transfer of information across these boundaries, so that the accuracy of the numerical scheme is preserved and flux conservation is guaranteed. In this paper, the numerical approach allowing to achieve this is presented. A comparison between the hybrid and the structured-grid methods is also carried out by considering a fully hexahedral multiblock mesh for which a few blocks have been transformed into unstructured. The performance of elsA-H for the simulation of internal flows will be demonstrated on a number of turbomachinery configurations.

  15. An economically designed, integrated quality and maintenance model using an adaptive Shewhart chart

    International Nuclear Information System (INIS)

    Panagiotidou, Sofia; Nenes, George

    2009-01-01

    This paper proposes a model for the economic design of a variable-parameter (Vp) Shewhart control chart used to monitor the mean in a process, where, apart from quality shifts, failures may also occur. Quality shifts result in poorer quality outcome, higher operational cost and higher failure rate. Thus, removal of such quality shifts, besides improving the quality of the outcome and reducing the quality cost, is also a preventive maintenance (PM) action since it reduces the probability of a failure and improves the equipment reliability. The proposed model allows the determination of the scheme parameters that minimize the total expected quality and maintenance cost of the procedure. The monitoring mechanism of the process employs an adaptive Vp-Shewhart control chart. To evaluate the effectiveness of the proposed model, its optimal expected cost is compared against the optimum cost of a fixed-parameter (Fp) chart

  16. Improving quality and the assurance of quality in the design and construction of nuclear power plants: a report to Congress

    International Nuclear Information System (INIS)

    Altman, W.; Ankrum, T.; Brach, W.

    1984-05-01

    A study was conducted of existing and alternative programs for improving quality and the assurance of quality in the design and construction of commercial nuclear power plants. A primary focus of the study was to determine the underlying causes of major quality-related problems in the construction of some nuclear power plants and the untimely detection and correction of these problems. The study concluded that the root cause for major quality-related problems was the failure or inability of some utility managements to effectively implement a management system that ensured adequate control over all aspects of the project. These management shortcoming arose in part from inexperience on the part of some project teams in the construction of nuclear power plants. NRC's past licensing and inspection practices did not adequately screen construction permit applicants for overall capability to manage or provide effective management oversight over the construction project. The study recommends a number of improvements in industry and NRC programs. For industry, the study recommends self-imposed rising standards of excellence, treatment of quality assurance as a management tool, not a substitute for management, improved trend analysis and identification of root causes of quality problems, and a program of comprehensive third party audits of present and future construction projects. To improve NRC programs, the study recommends a heavier emphasis on team inspections and resident inspectors, an enhanced review of new applicant's capabilities to construct commercial nuclear power plants, more attention to management issues, improved diagnostic and trending capabilities, improved quality and quality assurance for operating reactors, and development of guidance to facilitate the prioritization of quality assurance measures commensurate with the importance of plant structures, systems, and components to the achievement of safety

  17. Design and Optimization of Capacitated Supply Chain Networks Including Quality Measures

    Directory of Open Access Journals (Sweden)

    Krystel K. Castillo-Villar

    2014-01-01

    Full Text Available This paper presents (1 a novel capacitated model for supply chain network design which considers manufacturing, distribution, and quality costs (named SCND-COQ model and (2 five combinatorial optimization methods, based on nonlinear optimization, heuristic, and metaheuristic approaches, which are used to solve realistic instances of practical size. The SCND-COQ model is a mixed-integer nonlinear problem which can be used at a strategic planning level to design a supply chain network that maximizes the total profit subject to meeting an overall quality level of the final product at minimum costs. The SCND-COQ model computes the quality-related costs for the whole supply chain network considering the interdependencies among business entities. The effectiveness of the proposed solution approaches is shown using numerical experiments. These methods allow solving more realistic (capacitated supply chain network design problems including quality-related costs (inspections, rework, opportunity costs, and others within a reasonable computational time.

  18. USER REQUIREMENTS CUSTOMIZATION AND ATTRACTIVE QUALITY CREATION FOR DESIGN IMPROVEMENT ATTRIBUTES

    Directory of Open Access Journals (Sweden)

    Ismail Wilson Taifa

    2017-03-01

    Full Text Available The aim of this paper was to customize user requirements and quality creation for design improvement of furniture. The major purpose has been achieved with the use of Quality Function Deployment technique and Kano Model. The study involved 564 students from 3 engineering colleges. Extensive user requirements were identified with the help of Questionnaires. The use of House of Quality, Kano Model and Pareto Diagram helped in prioritizing all important features which are needed in customizing user requirements. The prioritized requirements include ergonomic design, desk adjustability, comfortability, product corners (sharp corners and latest material. All these factors both got high relative and absolute weight. Therefore, more engineering efforts need to be directed towards these requirements for achieving user customization for design improvement. The developed House of Quality with the help of Kano Model results has proved to be a good tool in customizing user requirements.

  19. Crafting qualities in designing QR-coded embroidery and bedtime stories

    NARCIS (Netherlands)

    Kuusk, K.; Wensveen, S.A.G.; Tomico, O.

    2014-01-01

    There is a renewed interest into crafts and what it can mean when integrating new technologies into textiles. This paper proposes to embed craft qualities and sustainable values into designing smart textile projects. Our design iterations QR-Coded Embroidery and Bedtime Stories combine textiles,

  20. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films

    NARCIS (Netherlands)

    Visser, J. Caroline; Dohmen, Willem M. C.; Hinrichs, Wouter L. J.; Breitkreutz, Joerg; Frijlink, Henderik W.; Woerdenbag, Herman J.

    2015-01-01

    The quality by design (QbD) approach was applied for optimizing the formulation of extemporaneously prepared orodispersible films (ODFs) using Design-Expert Software. The starting formulation was based on earlier experiments and contained the film forming agents hypromellose and carbomer 974P and

  1. The Incorporation of Quality Attributes into Online Course Design in Higher Education

    Science.gov (United States)

    Lenert, Kathleen Anne; Diane P. Janes

    2017-01-01

    A survey was designed incorporating questions on 28 attributes (compiled through a literature review) and considered to be quality features in online academic courses in higher education. This study sought to investigate the ongoing practice of instructional designers and instructors in the United States with respect to their incorporation of…

  2. Integrating Quality Matters into Hybrid Course Design: A Principles of Marketing Case Study

    Science.gov (United States)

    Young, Mark R.

    2014-01-01

    Previous research supports the idea that the success of hybrid or online delivery modes is more a function of course design than delivery media. This article describes a case study of a hybrid Principles of Marketing course that implemented a comprehensive redesign based on design principles espoused by the Quality Matters Program, a center for…

  3. Technical report of comparison in design control on R and D and industrial quality requirements

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides the methods on how to establish the requirements on nuclear R and D facilities. This report applies to the quality assurance(QA) programmes of the design, fabrication in research reactor. The organization having overall responsibility for the nuclear power item design, preservation, fabrication shall be described in this report in each stage of nuclear project

  4. How to Measure Quality of Service Using Unstructured Data Analysis: A General Method Design

    Directory of Open Access Journals (Sweden)

    Lucie Sperková,

    2015-10-01

    Full Text Available The aim of the paper is to design a general method usable for measuring the quality of the service from the customer’s point of view with the help of content analytics. Large amount of unstructured data is created by customers of the service. This data can provide a valuable feedback from the service usage. Customers talk among themselves about their experiences and feelings from consumption of the service. The design of the method is based on a systematic literature review in the area of the service quality and unstructured data analysis. Analytics and quality measurement models are collected and critically evaluated regarding their potential use for measuring IT service quality. The method can be used by IT service provider to measure and monitor service quality based on World-of-Mouth in order to continual service improvement.

  5. Re-conceiving building design quality: A review of building users in their social context.

    Science.gov (United States)

    Watson, Kelly J; Evans, James; Karvonen, Andrew; Whitley, Tim

    2016-05-01

    Considerable overlap exists between post-occupancy research evaluating building design quality and the concept of 'social value', popularised by its recent application to issues of the public realm. To outline this potential research agenda, the paper reviews design quality research on buildings in relation to users and their social context where the term 'social context' refers to building user group dynamics, a combination of organisational cultures, management strategies, and social norms and practices. The review is conducted across five key building types, namely housing, workplaces, healthcare, education, and the retail/service sector. Research commonalities and gaps are identified in order to build a more comprehensive picture of the design quality literature and its handling of users in their social context. The key findings concerning each building type are presented visually. It is concluded that the design quality field comprises a patchwork of relatively isolated studies of various building types, with significant potential for theoretical and empirical development through interdisciplinary collaboration. Users tend to be conceived as anonymous and autonomous individuals with little analysis of user identity or interaction. Further, the contextual impact of user group dynamics on the relationship between building design and building user is rarely addressed in the literature. Producing a more nuanced understanding of users in situ is proposed as an important area for future design quality research.

  6. Fuel quality and its effect on the design of power boilers in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Kotler, V.R.

    1984-05-01

    Statistical data, taken from Power, Proceedings of the American Power Conference and others, on developments since the 1950s in boiler design caused by the increasing use of lower quality fuel (subbituminous and lignite coals) are presented. The effect of pollution regulations in the USA on boiler design is discussed. The results of a 16 year study by the TVA on the decrease in coal quality fired in its boilers and its effect on boiler efficiency are presented. Methods of transport are surveyed. Descriptions and characteristics of several modern boilers designed by Babcock and Wilcox, Combustion Engineering, Foster-Wheeler and Riley Stoker are given. 13 references.

  7. UBICOMP-KAIZEN:The use of Japanese Quality Management methods for the Design of Smart Buildings

    OpenAIRE

    Schoch, Odilo

    2009-01-01

    This paper describes the successful development of adesign supporting method called ‘Ubicomp-Kaizen’ for the design ofcomputer-integrated ‘smart’ buildings. The tool uses known methodsof quality-management of the car-manufacturing industry andintegrates them into the architectural design process. By this, theCAAD-topics ‘design methodology’, ‘ubicomp/smart buildings’,‘interactive architecture’ and ‘Building Information Model (BIM)’ areinvolved. In result it proves the successful integration a...

  8. Designing a Clinical Data Warehouse Architecture to Support Quality Improvement Initiatives.

    Science.gov (United States)

    Chelico, John D; Wilcox, Adam B; Vawdrey, David K; Kuperman, Gilad J

    2016-01-01

    Clinical data warehouses, initially directed towards clinical research or financial analyses, are evolving to support quality improvement efforts, and must now address the quality improvement life cycle. In addition, data that are needed for quality improvement often do not reside in a single database, requiring easier methods to query data across multiple disparate sources. We created a virtual data warehouse at NewYork Presbyterian Hospital that allowed us to bring together data from several source systems throughout the organization. We also created a framework to match the maturity of a data request in the quality improvement life cycle to proper tools needed for each request. As projects progress in the Define, Measure, Analyze, Improve, Control stages of quality improvement, there is a proper matching of resources the data needs at each step. We describe the analysis and design creating a robust model for applying clinical data warehousing to quality improvement.

  9. Design, analysis, and interpretation of field quality-control data for water-sampling projects

    Science.gov (United States)

    Mueller, David K.; Schertz, Terry L.; Martin, Jeffrey D.; Sandstrom, Mark W.

    2015-01-01

    The process of obtaining and analyzing water samples from the environment includes a number of steps that can affect the reported result. The equipment used to collect and filter samples, the bottles used for specific subsamples, any added preservatives, sample storage in the field, and shipment to the laboratory have the potential to affect how accurately samples represent the environment from which they were collected. During the early 1990s, the U.S. Geological Survey implemented policies to include the routine collection of quality-control samples in order to evaluate these effects and to ensure that water-quality data were adequately representing environmental conditions. Since that time, the U.S. Geological Survey Office of Water Quality has provided training in how to design effective field quality-control sampling programs and how to evaluate the resultant quality-control data. This report documents that training material and provides a reference for methods used to analyze quality-control data.

  10. Oil-Free Turbomachinery Technologies for Long-Life, Maintenance-Free Power Generation Applications

    Science.gov (United States)

    Dellacorte, Christopher

    2013-01-01

    Turbines have long been used to convert thermal energy to shaft work for power generation. Conventional turbines rely upon oil-lubricated rotor supports (bearings, seals, etc.) to achieve low wear, high efficiency and reliability. Emerging Oil-Free technologies such as gas foil bearings and magnetic bearings offer a path for reduced weight and complexity and truly maintenance free systems. Oil-Free gas turbines, using gaseous and liquid fuels are commercially available in power outputs to at least 250kWe and are gaining acceptance for remote power generation where maintenance is a challenge. Closed Brayton Cycle (CBC) turbines are an approach to power generation that is well suited for long life space missions. In these systems, a recirculating gas is heated by nuclear, solar or other heat energy source then fed into a high-speed turbine that drives an electrical generator. For closed cycle systems such as these, the working fluid also passes through the bearing compartments thus serving as a lubricant and bearing coolant. Compliant surface foil gas bearings are well suited for the rotor support systems of these advanced turbines. Foil bearings develop a thin hydrodynamic gas film that separates the rotating shaft from the bearing preventing wear. During start-up and shut down when speeds are low, rubbing occurs. Solid lubricants are used to reduce starting torque and minimize wear. Other emerging technologies such as magnetic bearings can also contribute to robust and reliable Oil-Free turbomachinery. In this presentation, Oil-Free technologies for advanced rotor support systems will be reviewed as will the integration and development processes recommended for implementation.

  11. People’s Preferences of Urban Design Qualities for Walking on a Commercial Street

    Science.gov (United States)

    Ernawati, J.; Surjono; Sudarmo, B. S.

    2018-03-01

    This research aims to explore people’s preferences of urban design qualities for walking on a commercial street, with Kawi Street located in a commercial neighborhood in the town of Malang Indonesia as the case study. Based on a literature review, this study used eight urban design qualities, i.e., enclosure, legibility, human scale, transparency, complexity, coherence, linkage, and imageability. This study applied a survey research method using a self-administered paper-pencil questionnaire applying two measurement techniques: Likert scale was used to explore people’s evaluations of urban design qualities of the street, while multiple-rating scales were used to measure people’s preference for walking on the street. One hundred and ten people randomly selected as respondents. Regression analysis was employed to explore the influence of urban design qualities on people preference for walking. Results indicated four urban design qualities that affect people’s choice for walking on a commercial street, i.e., transparency, coherence, linkage, and imageability. Implications of the findings will be discussed in the paper.

  12. Quality by design approach in the optimization of the spray-drying process.

    Science.gov (United States)

    Baldinger, Arnaud; Clerdent, Lucas; Rantanen, Jukka; Yang, Mingshi; Grohganz, Holger

    2012-01-01

    The aim of this study was to illustrate the influence of the processing parameters, inlet temperature, atomization air flow rate and feed flow rate, on critical quality attributes of spray-dried powders using design of experiments (DoE). Spray-dried powders were characterized by laser diffraction, X-ray powder diffraction (XRPD) and near-infrared spectroscopy (NIR). Multivariate analysis of two different experimental designs was performed to elucidate the optimal process conditions. XRPD revealed that the spray-dried powders consisted of crystalline β-mannitol and amorphous trehalose. Non-invasive NIR measurement was successfully used for correlating the critical quality attribute particle size with size determined by laser diffraction. The full factorial design proved to be unsuitable due to the non-linear influence of factors. The composite face-centered design improved the quality of the models and showed both linear and non-linear influence of the parameters on the outcomes. A model explaining the influence of the factors on all quality attributes showed similar results as the models optimized for a single response. This study showed the applicability of DoE for the investigation of spray-dried powders. The knowledge of the interplay between process parameters and quality attributes will enable rational process design to achieve a desired outcome.

  13. Modeling in the quality by design environment: Regulatory requirements and recommendations for design space and control strategy appointment.

    Science.gov (United States)

    Djuris, Jelena; Djuric, Zorica

    2017-11-30

    Mathematical models can be used as an integral part of the quality by design (QbD) concept throughout the product lifecycle for variety of purposes, including appointment of the design space and control strategy, continual improvement and risk assessment. Examples of different mathematical modeling techniques (mechanistic, empirical and hybrid) in the pharmaceutical development and process monitoring or control are provided in the presented review. In the QbD context, mathematical models are predominantly used to support design space and/or control strategies. Considering their impact to the final product quality, models can be divided into the following categories: high, medium and low impact models. Although there are regulatory guidelines on the topic of modeling applications, review of QbD-based submission containing modeling elements revealed concerns regarding the scale-dependency of design spaces and verification of models predictions at commercial scale of manufacturing, especially regarding real-time release (RTR) models. Authors provide critical overview on the good modeling practices and introduce concepts of multiple-unit, adaptive and dynamic design space, multivariate specifications and methods for process uncertainty analysis. RTR specification with mathematical model and different approaches to multivariate statistical process control supporting process analytical technologies are also presented. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Coal-Based Oxy-Fuel System Evaluation and Combustor Development; Oxy-Fuel Turbomachinery Development for Energy Intensive Industrial Applications

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, Rebecca

    2013-03-31

    Clean Energy Systems, Inc. (CES) partnered with the U.S. Department of Energy’s National Energy Technology Laboratory in 2005 to study and develop a competing technology for use in future fossil-fueled power generation facilities that could operate with near zero emissions. CES’s background in oxy-fuel (O-F) rocket technology lead to the award of Cooperative Agreement DE-FC26-05NT42645, “Coal-Based Oxy-Fuel System Evaluation and Combustor Development,” where CES was to first evaluate the potential of these O-F power cycles, then develop the detailed design of a commercial-scale O-F combustor for use in these clean burning fossil-fueled plants. Throughout the studies, CES found that in order to operate at competitive cycle efficiencies a high-temperature intermediate pressure turbine was required. This led to an extension of the Agreement for, “Oxy-Fuel Turbomachinery Development for Energy Intensive Industrial Applications” where CES was to also develop an intermediate-pressure O-F turbine (OFT) that could be deployed in O-F industrial plants that capture and sequester >99% of produced CO2, at competitive cycle efficiencies using diverse fuels. The following report details CES’ activities from October 2005 through March 2013, to evaluate O-F power cycles, develop and validate detailed designs of O-F combustors (main and reheat), and to design, manufacture, and test a commercial-scale OFT, under the three-phase Cooperative Agreement.

  15. The quality estimation of exterior wall’s and window filling’s construction design

    Science.gov (United States)

    Saltykov, Ivan; Bovsunovskaya, Maria

    2017-10-01

    The article reveals the term of “artificial envelope” in dwelling building. Authors offer a complex multifactorial approach to the design quality estimation of external fencing structures, which is based on various parameters impact. These referred parameters are: functional, exploitation, cost, and also, the environmental index is among them. The quality design index Qк is inputting for the complex characteristic of observed above parameters. The mathematical relation of this index from these parameters is the target function for the quality design estimation. For instance, the article shows the search of optimal variant for wall and window designs in small, middle and large square dwelling premises of economic class buildings. The graphs of target function single parameters are expressed for the three types of residual chamber’s dimensions. As a result of the showing example, there is a choice of window opening’s dimensions, which make the wall’s and window’s constructions properly correspondent to the producible complex requirements. The authors reveal the comparison of recommended window filling’s square in accordance with the building standards, and the square, due to the finding of the optimal variant of the design quality index. The multifactorial approach for optimal design searching, which is mentioned in this article, can be used in consideration of various construction elements of dwelling buildings in accounting of suitable climate, social and economic construction area features.

  16. Teolenn: an efficient and customizable workflow to design high-quality probes for microarray experiments

    Science.gov (United States)

    Jourdren, Laurent; Duclos, Aurélie; Brion, Christian; Portnoy, Thomas; Mathis, Hugues; Margeot, Antoine; Le Crom, Stéphane

    2010-01-01

    Despite the development of new high-throughput sequencing techniques, microarrays are still attractive tools to study small genome organisms, thanks to sample multiplexing and high-feature densities. However, the oligonucleotide design remains a delicate step for most users. A vast array of software is available to deal with this problem, but each program is developed with its own strategy, which makes the choice of the best solution difficult. Here we describe Teolenn, a universal probe design workflow developed with a flexible and customizable module organization allowing fixed or variable length oligonucleotide generation. In addition, our software is able to supply quality scores for each of the designed probes. In order to assess the relevance of these scores, we performed a real hybridization using a tiling array designed against the Trichoderma reesei fungus genome. We show that our scoring pipeline correlates with signal quality for 97.2% of all the designed probes, allowing for a posteriori comparisons between quality scores and signal intensities. This result is useful in discarding any bad scoring probes during the design step in order to get high-quality microarrays. Teolenn is available at http://transcriptome.ens.fr/teolenn/. PMID:20176570

  17. The development of quality management techniques in civil engineering design and site supervision

    International Nuclear Information System (INIS)

    Cowan, A.J.

    1991-01-01

    Quality assurance techniques have developed considerably over the past few years, and in particular the application of Quality Management within a service industry such as civil engineering has evolved into a well developed management control system. James Williamson and Partners were the first members of the Association of Consulting Engineers successfully to achieve third party accreditation with BSI for civil and structural design. The initial system was generated for work on Torness Power Station in the early 1980s, and the firm has, in the last ten years, developed a flexible quality system to effectively control and co-ordinate complex projects. This paper discusses the use of quality assurance (QA) techniques in a civil engineering design office, looking at a few areas where the requirements of BS 5750 and BS 5882 are difficult to interpret. Some observations are also made on the adoption of QA for site supervision. (author)

  18. Testing Requirements to Manage Data Exchange Specifications in Enterprise Integration - A Schema Design Quality Focus.

    Energy Technology Data Exchange (ETDEWEB)

    Kulvatunyou, Boonserm [ORNL; Ivezic, Nenad [ORNL; Buhwan, Jeong [POSTECH University, South Korea

    2004-07-01

    In this paper, we describe the requirements to test W3C XML Schema usage when defining message schemas for data exchange in any large and evolving enterprise integration project. We then decompose the XML Schema testing into four (4) aspects including the message schema conformance to the XML Schema specification grammar, the message schema conformance to the XML Schema specification semantics, the message schema conformance to design quality testing, and canonical semantics testing of the message schema. We describe these four testing aspects in some detail and point to other related efforts. We further focus to provide some technical details for the message schema design quality testing. As a future work, we describe the requirements for canonical semantics testing and potential solution approaches. Finally, we describe an implementation architecture for the message schema design quality testing.

  19. Quality assurance in the procurement, design and manufacture of nuclear fuel assemblies

    International Nuclear Information System (INIS)

    1983-01-01

    This Safety Guide provides requirements and recommendations for quality assurance programmes that are relevant for the unique features of the procurement, design, manufacture, inspection, testing, packaging, shipping, storage, and receiving inspection of fuel assemblies for nuclear power plants. The generic quality assurance requirements of the Code and related Safety Guides are referred to where applicable, and are duplicated in this document where increased emphasis is desirable

  20. A slow fashion design model for bluejeans using house of quality approach

    Science.gov (United States)

    Nergis, B.; Candan, C.; Sarısaltık, S.; Seneloglu, N.; Bozuk, R.; Amzayev, K.

    2017-10-01

    The purpose of this study was to develop a slow fashion design model using the house of quality model (HOQ) to provide fashion designers a tool to improve the overall sustainability of denim jeans for Y generation consumers in Turkish market. In doing so, a survey was conducted to collect data on the design & performance expectations as well as the perception of slow fashion in design process of denim jeans of the targeted consumer group. The results showed that Y generation in the market gave the most importance to the sustainable production techniques when identifying slow fashion.

  1. Application of quality by design for 3D printed bone prostheses and scaffolds.

    Science.gov (United States)

    Martinez-Marquez, Daniel; Mirnajafizadeh, Ali; Carty, Christopher P; Stewart, Rodney A

    2018-01-01

    3D printing is an emergent manufacturing technology recently being applied in the medical field for the development of custom bone prostheses and scaffolds. However, successful industry transformation to this new design and manufacturing approach requires technology integration, concurrent multi-disciplinary collaboration, and a robust quality management framework. This latter change enabler is the focus of this study. While a number of comprehensive quality frameworks have been developed in recent decades to ensure that the manufacturing of medical devices produces reliable products, they are centred on the traditional context of standardised manufacturing techniques. The advent of 3D printing technologies and the prospects for mass customisation provides significant market opportunities, but also presents a serious challenge to regulatory bodies tasked with managing and assuring product quality and safety. Before 3D printing bone prostheses and scaffolds can gain traction, industry stakeholders, such as regulators, clients, medical practitioners, insurers, lawyers, and manufacturers, would all require a high degree of confidence that customised manufacturing can achieve the same quality outcomes as standardised manufacturing. A Quality by Design (QbD) approach to custom 3D printed prostheses can help to ensure that products are designed and manufactured correctly from the beginning without errors. This paper reports on the adaptation of the QbD approach for the development process of 3D printed custom bone prosthesis and scaffolds. This was achieved through the identification of the Critical Quality Attributes of such products, and an extensive review of different design and fabrication methods for 3D printed bone prostheses. Research outcomes include the development of a comprehensive design and fabrication process flow diagram, and categorised risks associated with the design and fabrication processes of such products. An extensive systematic literature review

  2. Application of quality by design for 3D printed bone prostheses and scaffolds

    Science.gov (United States)

    Martinez-Marquez, Daniel; Mirnajafizadeh, Ali; Carty, Christopher P.

    2018-01-01

    3D printing is an emergent manufacturing technology recently being applied in the medical field for the development of custom bone prostheses and scaffolds. However, successful industry transformation to this new design and manufacturing approach requires technology integration, concurrent multi-disciplinary collaboration, and a robust quality management framework. This latter change enabler is the focus of this study. While a number of comprehensive quality frameworks have been developed in recent decades to ensure that the manufacturing of medical devices produces reliable products, they are centred on the traditional context of standardised manufacturing techniques. The advent of 3D printing technologies and the prospects for mass customisation provides significant market opportunities, but also presents a serious challenge to regulatory bodies tasked with managing and assuring product quality and safety. Before 3D printing bone prostheses and scaffolds can gain traction, industry stakeholders, such as regulators, clients, medical practitioners, insurers, lawyers, and manufacturers, would all require a high degree of confidence that customised manufacturing can achieve the same quality outcomes as standardised manufacturing. A Quality by Design (QbD) approach to custom 3D printed prostheses can help to ensure that products are designed and manufactured correctly from the beginning without errors. This paper reports on the adaptation of the QbD approach for the development process of 3D printed custom bone prosthesis and scaffolds. This was achieved through the identification of the Critical Quality Attributes of such products, and an extensive review of different design and fabrication methods for 3D printed bone prostheses. Research outcomes include the development of a comprehensive design and fabrication process flow diagram, and categorised risks associated with the design and fabrication processes of such products. An extensive systematic literature review

  3. Quality by Design approach for studying the impact of formulation and process variables on product quality of oral disintegrating films.

    Science.gov (United States)

    Mazumder, Sonal; Pavurala, Naresh; Manda, Prashanth; Xu, Xiaoming; Cruz, Celia N; Krishnaiah, Yellela S R

    2017-07-15

    The present investigation was carried out to understand the impact of formulation and process variables on the quality of oral disintegrating films (ODF) using Quality by Design (QbD) approach. Lamotrigine (LMT) was used as a model drug. Formulation variable was plasticizer to film former ratio and process variables were drying temperature, air flow rate in the drying chamber, drying time and wet coat thickness of the film. A Definitive Screening Design of Experiments (DoE) was used to identify and classify the critical formulation and process variables impacting critical quality attributes (CQA). A total of 14 laboratory-scale DoE formulations were prepared and evaluated for mechanical properties (%elongation at break, yield stress, Young's modulus, folding endurance) and other CQA (dry thickness, disintegration time, dissolution rate, moisture content, moisture uptake, drug assay and drug content uniformity). The main factors affecting mechanical properties were plasticizer to film former ratio and drying temperature. Dissolution rate was found to be sensitive to air flow rate during drying and plasticizer to film former ratio. Data were analyzed for elucidating interactions between different variables, rank ordering the critical materials attributes (CMA) and critical process parameters (CPP), and for providing a predictive model for the process. Results suggested that plasticizer to film former ratio and process controls on drying are critical to manufacture LMT ODF with the desired CQA. Published by Elsevier B.V.

  4. A quality by design study applied to an industrial pharmaceutical fluid bed granulation.

    Science.gov (United States)

    Lourenço, Vera; Lochmann, Dirk; Reich, Gabriele; Menezes, José C; Herdling, Thorsten; Schewitz, Jens

    2012-06-01

    The pharmaceutical industry is encouraged within Quality by Design (QbD) to apply science-based manufacturing principles to assure quality not only of new but also of existing processes. This paper presents how QbD principles can be applied to an existing industrial pharmaceutical fluid bed granulation (FBG) process. A three-step approach is presented as follows: (1) implementation of Process Analytical Technology (PAT) monitoring tools at the industrial scale process, combined with multivariate data analysis (MVDA) of process and PAT data to increase the process knowledge; (2) execution of scaled-down designed experiments at a pilot scale, with adequate PAT monitoring tools, to investigate the process response to intended changes in Critical Process Parameters (CPPs); and finally (3) the definition of a process Design Space (DS) linking CPPs to Critical to Quality Attributes (CQAs), within which product quality is ensured by design, and after scale-up enabling its use at the industrial process scale. The proposed approach was developed for an existing industrial process. Through enhanced process knowledge established a significant reduction in product CQAs, variability already within quality specifications ranges was achieved by a better choice of CPPs values. The results of such step-wise development and implementation are described. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Design and methods of the Southeast Stream Quality Assessment (SESQA), 2014

    Science.gov (United States)

    Journey, Celeste A.; Van Metre, Peter C.; Bell, Amanda H.; Button, Daniel T.; Garrett, Jessica D.; Nakagaki, Naomi; Qi, Sharon L.; Bradley, Paul M.

    2015-07-15

    During 2014, the U.S. Geological Survey (USGS) National Water-Quality Assessment Program (NAWQA) assessed stream quality across the Piedmont and southern Appalachian Mountain regions of the southeastern United States. This Southeast Stream Quality Assessment (SESQA) simultaneously characterized watershed and stream-reach water-quality stressors along with instream biological conditions, in order to better understand regional stressor-effects relations. The goal of SESQA is to provide communities and policymakers with information about those human and environmental factors that have the greatest impact on stream quality across the region. The SESQA design focused on hydrologic alteration and urbanization because of their importance as ecological stressors of particular concern to Southeast region resource managers.

  6. Critical to quality in telemedicine service management: application of DFSS (Design for Six Sigma) and SERVQUAL).

    Science.gov (United States)

    Yun, Eun Kyoung; Chun, Kee Moon

    2008-01-01

    Telemedicine generally refers to the use of communications and information technologies for the delivery of health care. owever, telemedicine is not merely a simple combination of health care and technology. The researchers propose a systematic approach for assessing needs of telemedicine customers, called critical-to-quality (CTQ) in Six Sigma, with a purpose of continuous quality improvement. The combination approach using DFSS (Design for Six Sigma) and SERVQUAL (Service Quality Framework) was applied to define the critical quality attributes of telemedicine service management and to match them with the current telemedicine process. With a step-by-step procedure, telemedicine service process was reviewed and all the important CTQ candidates identified via a case study. The findings suggest that nurses need further understanding and research methods that will improve and manage the quality of health care service in various medical fields.

  7. Nanosystem trends in drug delivery using quality-by-design concept.

    Science.gov (United States)

    Li, Jing; Qiao, Yanjiang; Wu, Zhisheng

    2017-06-28

    Quality by design (QbD) has become an inevitable trend because of its benefits for product quality and process understanding. Trials have been conducted using QbD in nanosystems' optimization. This paper reviews the application of QbD for processing nanosystems and summarizes the application procedure. It provides prospective guidelines for future investigations that apply QbD to nanosystem manufacturing processes. Employing the QbD concept in this way is a novel area in nanosystem quality. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Active power line conditioners design, simulation and implementation for improving power quality

    CERN Document Server

    Revuelta, Patricio Salmeron; Litrán, Salvador Pérez

    2015-01-01

    Active Power Line Conditioners: Design, Simulation and Implementation for Improving Power Quality presents a rigorous theoretical and practical approach to active power line conditioners, one of the subjects of most interest in the field of power quality. Its broad approach offers a journey that will allow power engineering professionals, researchers, and graduate students to learn more about the latest landmarks on the different APLC configurations for load active compensation. By introducing the issues and equipment needs that arise when correcting the lack of power quality in power grids

  9. Design and Implementation of the Harvard Fellowship in Patient Safety and Quality.

    Science.gov (United States)

    Gandhi, Tejal K; Abookire, Susan A; Kachalia, Allen; Sands, Kenneth; Mort, Elizabeth; Bommarito, Grace; Gagne, Jane; Sato, Luke; Weingart, Saul N

    2016-01-01

    The Harvard Fellowship in Patient Safety and Quality is a 2-year physician-oriented training program with a strong operational orientation, embedding trainees in the quality departments of participating hospitals. It also integrates didactic and experiential learning and offers the option of obtaining a master's degree in public health. The program focuses on methodologically rigorous improvement and measurement, with an emphasis on the development and implementation of innovative practice. The operational orientation is intended to foster the professional development of future quality and safety leaders. The purpose of this article is to describe the design and development of the fellowship. © The Author(s) 2014.

  10. Design and installation of a system of quality for the specialized services of irradiation

    International Nuclear Information System (INIS)

    Rodriguez, Y.; Romero, M.; Castillo, E.; Villoch, A.; Cruz, S.

    1999-01-01

    This study is traced as objective the the design and installation of a System of Quality of agreement to the norm ISO 9002 and the NC-ISO/IEC Guide 25. For this a program was elaborated that it embraced the following phases: organization, installation and maintenance of the system. The elements that would conform the whole program of quality of the irradiation services they would be given from the qualification of the material to process until the certification of the dose imparted to the product; as well as the internal and external control of the quality in the own one installation

  11. Quality management for design engineering for San Onofre nuclear generating station

    International Nuclear Information System (INIS)

    Thompson, P.C.; Baker, R.L.

    1991-01-01

    Quality management, as applied to design engineering for the San Onofre nuclear generating station, provides a systematic process for data collection and analysis of performance indicators for quality, cost, and delivery of design modifications for the three operating units. Southern California Edison (SCE) and Bechtel Power Corporation (BPC) have collaborated to establish a performance baseline from nearly 2 years of data. This paper discusses how the baseline was developed and how it can be used to predict and assess future performance. It further discusses new insights to the engineering process and opportunities for improvements that have been identified

  12. Robust design in generelaised linear models for improving the quality of polyurethane soles

    Directory of Open Access Journals (Sweden)

    Castro, Armando Mares

    2015-11-01

    Full Text Available In a process that manufactures polyurethane soles by casting, a number of problems lead to different types of defects on the sole, causing significant economic losses for the company. In order to improve the product quality and decrease the number of defects, this study conducts an experimental design in the context of robust design. Since the response variable is binary, the statistical analysis was performed using generalised linear models. The operational methodology reduced the percentage of defects, while combining the experimental technique and control systems to achieve superior quality and a consequent reduction in costs.

  13. Design and Development of a Nearable Wireless System to Control Indoor Air Quality and Indoor Lighting Quality

    Directory of Open Access Journals (Sweden)

    Francesco Salamone

    2017-05-01

    Full Text Available The article describes the results of the project “open source smart lamp” aimed at designing and developing a smart object able to manage and control the indoor environmental quality (IEQ of the built environment. A first version of this smart object, built following a do-it-yourself (DIY approach using a microcontroller, an integrated temperature and relative humidity sensor, and techniques of additive manufacturing, allows the adjustment of the indoor thermal comfort quality (ICQ, by interacting directly with the air conditioner. As is well known, the IEQ is a holistic concept including indoor air quality (IAQ, indoor lighting quality (ILQ and acoustic comfort, besides thermal comfort. The upgrade of the smart lamp bridges the gap of the first version of the device providing the possibility of interaction with the air exchange unit and lighting system in order to get an overview of the potential of a nearable device in the management of the IEQ. The upgraded version was tested in a real office equipped with mechanical ventilation and an air conditioning system. This office was occupied by four workers. The experiment is compared with a baseline scenario and the results show how the application of the nearable device effectively optimizes both IAQ and ILQ.

  14. Quality by design approach: application of artificial intelligence techniques of tablets manufactured by direct compression.

    Science.gov (United States)

    Aksu, Buket; Paradkar, Anant; de Matas, Marcel; Ozer, Ozgen; Güneri, Tamer; York, Peter

    2012-12-01

    The publication of the International Conference of Harmonization (ICH) Q8, Q9, and Q10 guidelines paved the way for the standardization of quality after the Food and Drug Administration issued current Good Manufacturing Practices guidelines in 2003. "Quality by Design", mentioned in the ICH Q8 guideline, offers a better scientific understanding of critical process and product qualities using knowledge obtained during the life cycle of a product. In this scope, the "knowledge space" is a summary of all process knowledge obtained during product development, and the "design space" is the area in which a product can be manufactured within acceptable limits. To create the spaces, artificial neural networks (ANNs) can be used to emphasize the multidimensional interactions of input variables and to closely bind these variables to a design space. This helps guide the experimental design process to include interactions among the input variables, along with modeling and optimization of pharmaceutical formulations. The objective of this study was to develop an integrated multivariate approach to obtain a quality product based on an understanding of the cause-effect relationships between formulation ingredients and product properties with ANNs and genetic programming on the ramipril tablets prepared by the direct compression method. In this study, the data are generated through the systematic application of the design of experiments (DoE) principles and optimization studies using artificial neural networks and neurofuzzy logic programs.

  15. Impact of National Ambient Air Quality Standards Nonattainment Designations on Particulate Pollution and Health.

    Science.gov (United States)

    Zigler, Corwin M; Choirat, Christine; Dominici, Francesca

    2018-03-01

    Despite dramatic air quality improvement in the United States over the past decades, recent years have brought renewed scrutiny and uncertainty surrounding the effectiveness of specific regulatory programs for continuing to improve air quality and public health outcomes. We employ causal inference methods and a spatial hierarchical regression model to characterize the extent to which a designation of "nonattainment" with the 1997 National Ambient Air Quality Standard for ambient fine particulate matter (PM2.5) in 2005 causally affected ambient PM2.5 and health outcomes among over 10 million Medicare beneficiaries in the Eastern United States in 2009-2012. We found that, on average across all retained study locations, reductions in ambient PM2.5 and Medicare health outcomes could not be conclusively attributed to the nonattainment designations against the backdrop of other regional strategies that impacted the entire Eastern United States. A more targeted principal stratification analysis indicates substantial health impacts of the nonattainment designations among the subset of areas where the designations are estimated to have actually reduced ambient PM2.5 beyond levels achieved by regional measures, with noteworthy reductions in all-cause mortality, chronic obstructive pulmonary disorder, heart failure, ischemic heart disease, and respiratory tract infections. These findings provide targeted evidence of the effectiveness of local control measures after nonattainment designations for the 1997 PM2.5 air quality standard.

  16. Design verification of the CANFLEX fuel bundle - quality assurance requirements for mechanical flow testing

    International Nuclear Information System (INIS)

    Alavi, P.; Oldaker, I.E.; Chung, C.H.; Suk, H.C.

    1997-01-01

    As part of the design verification program for the new fuel bundle, a series of out-reactor tests was conducted on the CANFLEX 43-element fuel bundle design. These tests simulated current CANDU 6 reactor normal operating conditions of flow, temperature and pressure. This paper describes the Quality Assurance (QA) Program implemented for the tests that were run at the testing laboratories of Atomic Energy of Canada Limited (AECL) and Korea Atomic energy Research Institute (KAERI). (author)

  17. Choosing a Cluster Sampling Design for Lot Quality Assurance Sampling Surveys

    OpenAIRE

    Hund, Lauren; Bedrick, Edward J.; Pagano, Marcello

    2015-01-01

    Lot quality assurance sampling (LQAS) surveys are commonly used for monitoring and evaluation in resource-limited settings. Recently several methods have been proposed to combine LQAS with cluster sampling for more timely and cost-effective data collection. For some of these methods, the standard binomial model can be used for constructing decision rules as the clustering can be ignored. For other designs, considered here, clustering is accommodated in the design phase. In this paper, we comp...

  18. Evidence-Based Design Features Improve Sleep Quality Among Psychiatric Inpatients.

    Science.gov (United States)

    Pyrke, Ryan J L; McKinnon, Margaret C; McNeely, Heather E; Ahern, Catherine; Langstaff, Karen L; Bieling, Peter J

    2017-10-01

    The primary aim of the present study was to compare sleep characteristics pre- and post-move into a state-of-the-art mental health facility, which offered private sleeping quarters. Significant evidence points toward sleep disruption among psychiatric inpatients. It is unclear, however, how environmental factors (e.g., dorm-style rooms) impact sleep quality in this population. To assess sleep quality, a novel objective technology, actigraphy, was used before and after a facility move. Subjective daily interviews were also administered, along with the Horne-Ostberg Morningness-Eveningness Questionnaire and the Pittsburgh Sleep Quality Index. Actigraphy revealed significant improvements in objective sleep quality following the facility move. Interestingly, subjective report of sleep quality did not correlate with the objective measures. Circadian sleep type appeared to play a role in influencing subjective attitudes toward sleep quality. Built environment has a significant effect on the sleep quality of psychiatric inpatients. Given well-documented disruptions in sleep quality present among psychiatric patients undergoing hospitalization, design elements like single patient bedrooms are highly desirable.

  19. Quality-by-design approach for the development of telmisartan potassium tablets.

    Science.gov (United States)

    Oh, Ga-Hui; Park, Jin-Hyun; Shin, Hye-Won; Kim, Joo-Eun; Park, Young-Joon

    2018-05-01

    A quality-by-design approach was adopted to develop telmisartan potassium (TP) tablets, which were bioequivalent with the commercially available Micardis ® (telmisartan free base) tablets. The dissolution pattern and impurity profile of TP tablets differed from those of Micardis ® tablets because telmisartan free base is poorly soluble in water. After identifying the quality target product profile and critical quality attributes (CQAs), drug dissolution, and impurities were predicted to be risky CQAs. To determine the exact range and cause of risks, we used the risk assessment (RA) tools, preliminary hazard analysis and failure mode and effect analysis to determine the parameters affecting drug dissolution, impurities, and formulation. The range of the design space was optimized using the face-centered central composite design among the design of experiment (DOE) methods. The binder, disintegrant, and kneading time in the wet granulation were identified as X values affecting Y values (disintegration, hardness, friability, dissolution, and impurities). After determining the design space with the desired Y values, the TP tablets were formulated and their dissolution pattern was compared with that of the reference tablet. The selected TP tablet formulated using design space showed a similar dissolution to that of Micardis ® tablets at pH 7.5. The QbD approach TP tablet was bioequivalent to Micardis ® tablets in beagle dogs.

  20. Design of a quality assurance system in the nuclear fuel fabrication

    International Nuclear Information System (INIS)

    Garcia Rojas Palacios, L.

    1992-01-01

    A)For the first time a project on nuclear fuel fabrication is going to be lead in this country. For this reason the work is oriented to establish a quality assurance system for the different stages of fuel fabrication. C) The work of this thesis was developed first by means of an analysis of quality philosophies of Deming, Ishikawa, Juran and Crosby from which several important points were stracted to be used in the designed quality system. Metrology and normalization are so important for quality control that a study of them is made considering definitions, unit systems and type of errors (for Metrology) as well as standards for quality systems, qualification, destructive and non destructive tests, shipment, packing for nuclear power plants. With the standards as a basis, the working strategy for the system was reached, as well as the design of control cards and the design of documents for inspection control, personnel and its documentation and finally the diagrams for each one of the fabrication stages

  1. The use of the general image quality equation in the design and evaluation of imaging systems

    Science.gov (United States)

    Cota, Steve A.; Florio, Christopher J.; Duvall, David J.; Leon, Michael A.

    2009-08-01

    The design of any modern imaging system is the end result of many trade studies, each seeking to optimize image quality within real world constraints such as cost, schedule and overall risk. The National Imagery Interpretability Rating Scale (NIIRS) is a useful measure of image quality, because, by characterizing the overall interpretability of an image, it combines into one metric those contributors to image quality to which a human interpreter is most sensitive. The main drawback to using a NIIRS rating as a measure of image quality in engineering trade studies is the fact that it is tied to the human observer and cannot be predicted from physical principles and engineering parameters alone. The General Image Quality Equation (GIQE) of Leachtenauer et al. 1997 [Appl. Opt. 36, 8322-8328 (1997)] is a regression of actual image analyst NIIRS ratings vs. readily calculable engineering metrics, and provides a mechanism for using the expected NIIRS rating of an imaging system in the design and evaluation process. In this paper, we will discuss how we use the GIQE in conjunction with The Aerospace Corporation's Parameterized Image Chain Analysis & Simulation SOftware (PICASSO) to evaluate imager designs, taking a hypothetical high resolution commercial imaging system as an example.

  2. Design of environmentally friendly calcium sulfate-based building materials : towards an improved indoor air quality

    NARCIS (Netherlands)

    Yu, Q.

    2012-01-01

    This thesis addresses the performance based design and development of an environmentally friendly calcium sulfate-based indoor building product towards an improved indoor air quality. Here "environmental friendly" is referred to the environment related subjects including: (1) the selection of raw

  3. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films.

    Science.gov (United States)

    Visser, J Carolina; Dohmen, Willem M C; Hinrichs, Wouter L J; Breitkreutz, Jörg; Frijlink, Henderik W; Woerdenbag, Herman J

    2015-05-15

    The quality by design (QbD) approach was applied for optimizing the formulation of extemporaneously prepared orodispersible films (ODFs) using Design-Expert® Software. The starting formulation was based on earlier experiments and contained the film forming agents hypromellose and carbomer 974P and the plasticizer glycerol (Visser et al., 2015). Trometamol and disodium EDTA were added to stabilize the solution. To optimize this formulation a quality target product profile was established in which critical quality attributes (CQAs) such as mechanical properties and disintegration time were defined and quantified. As critical process parameters (CPP) that were evaluated for their effect on the CQAs the percentage of hypromellose and the percentage of glycerol as well as the drying time were chosen. Response surface methodology (RMS) was used to evaluate the effects of the CPPs on the CQAs of the final product. The main factor affecting tensile strength and Young's modulus was the percentage of glycerol. Elongation at break was mainly influenced by the drying temperature. Disintegration time was found to be sensitive to the percentage of hypromellose. From the results a design space could be created. As long as the formulation and process variables remain within this design space, a product is obtained with desired characteristics and that meets all set quality requirements. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Standards Based Design: Teaching K-12 Educators to Build Quality Online Courses

    Science.gov (United States)

    Quiroz, René E.; Ritter, Nicola L.; Li, Yun; Newton, Rhonda C.; Palkar, Trupti

    2016-01-01

    The number of online courses, programs, and schools are growing exponentially in K-12 education. Given the unique nature of online courses and the distinct skills necessary to create a quality online course, it is essential that effective professional development be provided for teachers designing online courses. Online courses need to be of the…

  5. An Electronic Service Quality Reference Model for Designing E-Commerce Websites Which Maximizes Customer Satisfaction

    Science.gov (United States)

    Shaheen, Amer N.

    2011-01-01

    This research investigated Electronic Service Quality (E-SQ) features that contribute to customer satisfaction in an online environment. The aim was to develop an approach which improves E-CRM processes and enhances online customer satisfaction. The research design adopted mixed methods involving qualitative and quantitative methods to…

  6. 78 FR 40015 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2013-07-03

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants; District of Columbia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator Units AGENCY: Environmental... negative declaration for hospital/medical/infectious waste incinerator (HMIWI) units within the District of...

  7. 77 FR 3389 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2012-01-24

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants, State of West Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator Units, Plan Revision... final action to approve a revision to the West Virginia hospital/medical/infectious waste incinerator...

  8. 78 FR 40087 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2013-07-03

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants; District of Columbia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator Units AGENCY: Environmental...) section 111(d)/129 negative declaration for the District of Columbia for hospital/medical/infectious waste...

  9. 75 FR 73967 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2010-11-30

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants, State of Delaware; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator (HMIWI) Units, Negative Declaration... Environmental Control, 89 Kings Highway, P.O. Box 1401, Dover, Delaware 19903. FOR FURTHER INFORMATION CONTACT...

  10. 75 FR 73996 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2010-11-30

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants; State of Delaware; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator (HMIWI) Units, Negative Declaration... Resources and Environmental Control, 89 Kings Highway, P.O. Box 1401, Dover, Delaware 19903. FOR FURTHER...

  11. 77 FR 3422 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2012-01-24

    ... Promulgation of State Air Quality Plans for Designated Facilities and Pollutants; State of West Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator Units, Plan Revision... revision to the West Virginia hospital/medical/infectious waste incinerator (HMIWI) Section 111(d)/ 129...

  12. A research approach for quality based design of healthy foods: Dried broccoli as a case study

    NARCIS (Netherlands)

    Oliviero, T.; Verkerk, R.; Dekker, M.

    2013-01-01

    An approach for process design based on optimization of product quality attributes is presented. Adsorption drying of broccoli with retention of its health benefits is taken as an example to illustrate the approach. Related to its content of glucosinolates, broccoli has a high potential to reduce

  13. Design Factors Influencing Quality of Building Projects in Nigeria: Consultants' Perception

    Directory of Open Access Journals (Sweden)

    Lukumon Oyedele

    2012-11-01

    Full Text Available Various factors identified from the literature that caninfluence quality of building projects in Nigeria have beenstudied by means of questionnaire survey sent to architects,engineers and quantity surveyors in the industry. From atotal response of 107 consultants, the importance of eachfactor was obtained via severity and frequency responsesof the factors. Data analysis includes comparisons ofranking among consultants using severity, frequency andimportance indexes, correlation analysis, and percentagerank agreement factor (PRAF to measure the agreement inthe importance ranking among the consultants.Correlation results between the professionals are architects/quantity surveyors (0.75, architects/engineers (0.21 ,and engineers/quantity surveyors (0.24. The percentagerank agreement factor (PRAF shows that the five mostimportant factors affecting quality are 'design changes'(78.9%; 'inadequate involvement of other professionalsduring the design stage' (78.9%; 'insufficient andunrealistic constraints of project cost' (71.1 %; 'poor levelof commitment to quality improvement among designprofessionals' (63.2%; and 'making design decisions oncost and not value of work' (55.3%. The results of this studywould provide feedback for the clients, project and qualitymangers and all the consultants in the industry, so thateffective management of quality can be ensured from theconceptual-design stage of the project.

  14. The quality of procedures to assess and credit prior learning: Implications for design.

    NARCIS (Netherlands)

    Joosten-ten Brinke, Desirée; Sluijsmans, Dominique; Brand-Gruwel, Saskia; Jochems, Wim

    2008-01-01

    Joosten-ten Brinke, D., Sluijsmans, D. M. A., Brand-Gruwel, S., & Jochems, W. M. G. (2008). The quality of procedures to assess and credit prior learning: Implications for design. Educational Research Review, 3, 51-65. doi:10.1016/j.edurev.2007.08.001.

  15. Economic-based design of engineering systems with degrading components using probabilistic loss of quality

    International Nuclear Information System (INIS)

    Son, Young Kap; Savage, Gordon J.; Chang, Seog Weon

    2007-01-01

    The allocation of means and tolerances to provide quality, functional reliability and performance reliability in engineering systems is a challenging problem. Traditional measures to help select the best means and tolerances include mean time to failure and its variance: however, they have some shortcomings. In this paper, a monetary measure based on present worth is invoked as a more inclusive metric. We consider the sum of the production cost and the expected loss of quality cost over a planned horizon at the customer's discount rates. Key to the approach is a probabilistic loss of quality cost that incorporates the cumulative distribution function that arises from time-variant distributions of system performance measures due to degrading components. The proposed design approach investigates both degradation and uncertainty in component. Moreover, it tries to obviate problems of current Taguchi's loss function-based design approaches. Case studies show the practicality and promise of the approach

  16. Quality function deployment QFD: benefits and limitations when applied to designing myoelectric prosthesis hand

    Directory of Open Access Journals (Sweden)

    Erika Sofía Olaya Escobar

    2005-01-01

    Full Text Available Quality, cost and time spent in developing products have a direct impact on a company's productivity, market share and profitability. Greater attention must be paid to quality and quicker responses made as customers become more aware of satisfying their longings. This means that a company must be first in delivering a product or service which customers desire if ti wishes to gain and maintain market share. A company's market share and profit margin will depend on the balance and optimisation achieved between quality, cost and time. It is thus important to implant a method like Quality Function Deployment (QFD leading to planning product development during eartly design stages and consequently establish such equilibrium. This article's purpose is to present benefits and limitations regarding QFD; one should be aware of them and QFD development when identifying the most viable to be applied according to each company's inherent characteristics.

  17. VDMA contribution to functional safety of turbomachinery. Required risk reduction by safety functions for steam turbines; VDMA-Beitrag zur Funktionalen Sicherheit von Turbomaschinen. Notwendige Risikoreduktion durch Schutzfunktionen fuer Dampfturbinen

    Energy Technology Data Exchange (ETDEWEB)

    Wuest, Bernhard [Alstom Power Systems GmbH, Mannheim (Germany); Zelinger, Matthias [VDMA Power Systems, Frankfurt am Main (Germany); Havemann, Juergen [Siemens AG, Muelheim an der Ruhr (Germany). Energy Sector; Potten, Christian [MAN Diesel und Turbo SE, Oberhausen (Germany)

    2011-07-01

    Turbomachinery in power plants and industrial plants has to satisfy high safety standards. To meet these requirements, mechanical, hydraulic and electromechanical components have been used, most of them well-established already for decades. In recent years new standards for functional safety have been developed which address different target groups (IEC 61 528/511 for process industry IEC 62061 and ISO 13849 for mechanical engineering). The Working Panel 'Functional Safety of Turbomachinery' of VDMA defines rules for turbomachinery that will be presented with their background. (orig.)

  18. Design of an instrument to measure the quality of care in Physical Therapy.

    Science.gov (United States)

    Cavalheiro, Leny Vieira; Eid, Raquel Afonso Caserta; Talerman, Claudia; Prado, Cristiane do; Gobbi, Fátima Cristina Martorano; Andreoli, Paola Bruno de Araujo

    2015-01-01

    To design an instrument composed of domains that would demonstrate physical therapy activities and generate a consistent index to represent the quality of care in physical therapy. The methodology Lean Six Sigma was used to design the tool. The discussion involved seven different management groups staff. By means of brainstorming and Cause & Effect Matrix, we set up the process map. Five requirements composed the quality of care index in physical therapy, after application of the tool called Cause & Effect Matrix. The following requirements were assessed: physical therapist performance, care outcome indicator, adherence to physical therapy protocols, measure whether the prognosis and treatment outcome was achieved and Infrastructure. The proposed design allowed evaluating several items related to physical therapy service, enabling customization, reproducibility and benchmarking with other organizations. For management, this index provides the opportunity to identify areas for improvement and the strengths of the team and process of physical therapy care.

  19. Best of failure analysis of turbomachinery components. Highlights from two decades' of laboratory practice; Best of Schadensanalyse an Turbomaschinen. Die Highlights aus 20 Jahren Laborpraxis

    Energy Technology Data Exchange (ETDEWEB)

    Neidel, Andreas; Cagliyan, Erhan; Gaedicke, Tobias; Giller, Madleine; Hartanto, Vincentius; Kramm, Christine; Riesenbeck, Susanne; Ullrich, Thomas; Wallich, Sebastian; Woehl, Eric [Siemens AG, Power and Gas, Berlin (Germany). Werkstoffprueflabor

    2017-01-15

    In this contribution, the most interesting and educational failure cases are presented that the author came across during his over twenty years of laboratory practice as manager of the Materials Testing Laboratory of the Berlin Gas Turbine Plant of Siemens' Power and Gas Division. The case studies are presented and categorised in accordance with VDI Guideline 3822, the German failure analyst's guide to the subject of how to organise and run a root cause failure analysis. An effort was made to have each of the main four categories of failure causes represented, namely failures due to mechanical loading, corrosive failures, failures due to thermal loading, and tribological failures. Case studies include turbomachinery components that failed due to tensile overload, stress corrosion cracking, intergranular corrosion, hydrogen embrittlement, hot cracking, fretting, erosion, and galling. Affected components include valves, retaining rings, tubing and piping, burners, rotor disks, lifting lugs, and casings. Some of the presented cases were published in the new section ''Failure Analysis'' of Practical Metallography between October 2011 and the present time. Others were oral presentations at the Metallography conferences and at the annual failure analysis conferences ''VDI Jahrestagung Schadensanalyse'', held during that time. The focus of discussion of the failure cases in this paper is the metallurgical evaluation of failure causes. This is the approach taken in many small and industrial laboratories. A holistic approach of a failure case, which includes calculation and simulation methods such as finite element analysis, and which also implies a knowledge of the service stresses intended by design as well as the actual loading situation of the failed part, is not the aim of this contribution.

  20. POOR QUALITY OF PRODUCT DESIGN AS A CAUSE OF OCCUPATIONAL HEALTH HAZARDS: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    Janko D. Jovanović

    2007-12-01

    Full Text Available Quality of product design, which is expected from manufacturers on world market these days, could be provided exclusively by integral approach to product design. Such approach aims to achievement of optimal design solution of product, which is in line with a number of requirements, conditions and limitations of functionality, technology, market and usage. Only those manufacturers who are able to provide such approach to product design have prospective on market. This paper deals with a case study of neglect of integral approach to product design and its consequencies, in order to spread awareness of necessity of its adoption. Scope of this case study is focused on bridge crane whose working vibrations are meant to be potential cause of occupational desease of spinal column of crane operator.

  1. Design and implementation of pay-for-quality in primary healthcare: A case study from Iran

    Directory of Open Access Journals (Sweden)

    Jafar Sadegh Tabrizi

    2017-06-01

    Full Text Available Background The common methods of payment to healthcare providers such as capitation and salary are not designed to be stimulation for high quality healthcare. The pay-for -quality (P4Q programs are designed to provide the financial incentives to the service providers in order to improve quality of services based on specified criteria. Aims This study describes the design and implementation of a P4Q program in the primary healthcare (PHc in East Azerbaijan Province, Iran. Methods The present study is a case study that describes the process of designing and implementing the P4Q program in PHC in East-Azerbaijan province in 2015. To design the P4Q program, after identifying core components of the program through literature review and Focus Group Discussion (FGD, final decision about each component was made by achieving consensus from a panel of recognised experts in the area of PHc. Altogether two FGD and seven expert panel sessions were hold in EAPHC in order to design the P4Q program. Results Key components of P4Q program were selected by qualitative studies and the results were categorized in five headings including P4Q formula, quality measures, payment strategy, data reporting and performance evaluation. The formula consists of five elements including fixed payment, individual, team and organization performance and managerial appraisal. A total of 37 measures, which covers the domains of quality of PHc, human resource development and responsibility were selected. ‘Improvement’ and ‘absolute level of measures’ were selected as the payment strategy. The methods of data reporting included valid questionnaire, organization’s documents and medical records. The final P4Q program was used for paying incentives to all primary health care providers in public health centres affiliated to Tabriz University of Medical Sciences. Conclusion Designing and implementing the P4Q program led to a shift in paying the incentives to healthcare providers

  2. Testing the quality of images for permanent magnet desktop MRI systems using specially designed phantoms.

    Science.gov (United States)

    Qiu, Jianfeng; Wang, Guozhu; Min, Jiao; Wang, Xiaoyan; Wang, Pengcheng

    2013-12-21

    Our aim was to measure the performance of desktop magnetic resonance imaging (MRI) systems using specially designed phantoms, by testing imaging parameters and analysing the imaging quality. We designed multifunction phantoms with diameters of 18 and 60 mm for desktop MRI scanners in accordance with the American Association of Physicists in Medicine (AAPM) report no. 28. We scanned the phantoms with three permanent magnet 0.5 T desktop MRI systems, measured the MRI image parameters, and analysed imaging quality by comparing the data with the AAPM criteria and Chinese national standards. Image parameters included: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, signal-to-noise ratio (SNR), and image uniformity. The image parameters of three desktop MRI machines could be measured using our specially designed phantoms, and most parameters were in line with MRI quality control criterion, including: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, image uniformity and slice position accuracy. However, SNR was significantly lower than in some references. The imaging test and quality control are necessary for desktop MRI systems, and should be performed with the applicable phantom and corresponding standards.

  3. Testing the quality of images for permanent magnet desktop MRI systems using specially designed phantoms

    International Nuclear Information System (INIS)

    Qiu, Jianfeng; Wang, Guozhu; Min, Jiao; Wang, Xiaoyan; Wang, Pengcheng

    2013-01-01

    Our aim was to measure the performance of desktop magnetic resonance imaging (MRI) systems using specially designed phantoms, by testing imaging parameters and analysing the imaging quality. We designed multifunction phantoms with diameters of 18 and 60 mm for desktop MRI scanners in accordance with the American Association of Physicists in Medicine (AAPM) report no. 28. We scanned the phantoms with three permanent magnet 0.5 T desktop MRI systems, measured the MRI image parameters, and analysed imaging quality by comparing the data with the AAPM criteria and Chinese national standards. Image parameters included: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, signal-to-noise ratio (SNR), and image uniformity. The image parameters of three desktop MRI machines could be measured using our specially designed phantoms, and most parameters were in line with MRI quality control criterion, including: resonance frequency, high contrast spatial resolution, low contrast object detectability, slice thickness, geometrical distortion, image uniformity and slice position accuracy. However, SNR was significantly lower than in some references. The imaging test and quality control are necessary for desktop MRI systems, and should be performed with the applicable phantom and corresponding standards. (paper)

  4. Quality control in the design, fabrication and operation of the ITER magnets

    International Nuclear Information System (INIS)

    Mitchell, N.

    2006-01-01

    The ITER magnets are a complex system involving interfaces between many advanced technologies (superconductors, forging/welding/machining of massive structures, cryogenics, composites and moulding, high voltage electrical), yet at the same time form part of the ITER 'basic machine' which is required to operate at the design parameters, broadly failure free, for the design life of the tokamak. This imposes special quality control problems for the ITER project integration by the ITER International Team (IT) through the design, fabrication and operation. The magnets are not a test bed for new technology but in spite of this must use it, successfully. There is little previous experience of such a system but full functionality is required from the start, with limited opportunity for adjustment. And, finally, costs and schedule must be contained. The procurement strategy for the machine, with magnet components being supplied 'in kind', requires particular attention to the specifications, scheduling and quality control (QC). Special issues here are the testing requirements on magnet components, especially before final installation but also at critical intermediate stages. Unnecessary or ineffective quality control procedures cause delay and high costs, and divert attention from critical items. The main points of the magnet QC programme are summarised, including the use of codes and standards, qualification, manufacturing quality assurance, commissioning and in-service inspection

  5. A combined geostatistical-optimization model for the optimal design of a groundwater quality monitoring network

    Science.gov (United States)

    Kolosionis, Konstantinos; Papadopoulou, Maria P.

    2017-04-01

    Monitoring networks provide essential information for water resources management especially in areas with significant groundwater exploitation due to extensive agricultural activities. In this work, a simulation-optimization framework is developed based on heuristic optimization methodologies and geostatistical modeling approaches to obtain an optimal design for a groundwater quality monitoring network. Groundwater quantity and quality data obtained from 43 existing observation locations at 3 different hydrological periods in Mires basin in Crete, Greece will be used in the proposed framework in terms of Regression Kriging to develop the spatial distribution of nitrates concentration in the aquifer of interest. Based on the existing groundwater quality mapping, the proposed optimization tool will determine a cost-effective observation wells network that contributes significant information to water managers and authorities. The elimination of observation wells that add little or no beneficial information to groundwater level and quality mapping of the area can be obtain using estimations uncertainty and statistical error metrics without effecting the assessment of the groundwater quality. Given the high maintenance cost of groundwater monitoring networks, the proposed tool could used by water regulators in the decision-making process to obtain a efficient network design that is essential.

  6. A Design of Wireless Sensor Networks for a Power Quality Monitoring System

    Directory of Open Access Journals (Sweden)

    Sanggil Kang

    2010-11-01

    Full Text Available Power grids deal with the business of generation, transmission, and distribution of electric power. Recently, interest in power quality in electrical distribution systems has increased rapidly. In Korea, the communication network to deliver voltage, current, and temperature measurements gathered from pole transformers to remote monitoring centers employs cellular mobile technology. Due to high cost of the cellular mobile technology, power quality monitoring measurements are limited and data gathering intervals are large. This causes difficulties in providing the power quality monitoring service. To alleviate the problems, in this paper we present a communication infrastructure to provide low cost, reliable data delivery. The communication infrastructure consists of wired connections between substations and monitoring centers, and wireless connections between pole transformers and substations. For the wireless connection, we employ a wireless sensor network and design its corresponding data forwarding protocol to improve the quality of data delivery. For the design, we adopt a tree-based data forwarding protocol in order to customize the distribution pattern of the power quality information. We verify the performance of the proposed data forwarding protocol quantitatively using the NS-2 network simulator.

  7. A design of wireless sensor networks for a power quality monitoring system.

    Science.gov (United States)

    Lim, Yujin; Kim, Hak-Man; Kang, Sanggil

    2010-01-01

    Power grids deal with the business of generation, transmission, and distribution of electric power. Recently, interest in power quality in electrical distribution systems has increased rapidly. In Korea, the communication network to deliver voltage, current, and temperature measurements gathered from pole transformers to remote monitoring centers employs cellular mobile technology. Due to high cost of the cellular mobile technology, power quality monitoring measurements are limited and data gathering intervals are large. This causes difficulties in providing the power quality monitoring service. To alleviate the problems, in this paper we present a communication infrastructure to provide low cost, reliable data delivery. The communication infrastructure consists of wired connections between substations and monitoring centers, and wireless connections between pole transformers and substations. For the wireless connection, we employ a wireless sensor network and design its corresponding data forwarding protocol to improve the quality of data delivery. For the design, we adopt a tree-based data forwarding protocol in order to customize the distribution pattern of the power quality information. We verify the performance of the proposed data forwarding protocol quantitatively using the NS-2 network simulator.

  8. Application of the Quality by Design Approach to the Freezing Step of Freeze-Drying: Building the Design Space.

    Science.gov (United States)

    Arsiccio, Andrea; Pisano, Roberto

    2018-06-01

    The present work shows a rational method for the development of the freezing step of a freeze-drying cycle. The current approach to the selection of freezing conditions is still empirical and nonsystematic, thus resulting in poor robustness of control strategy. The final aim of this work is to fill this gap, describing a rational procedure, based on mathematical modeling, for properly choosing the freezing conditions. Mechanistic models are used for the prediction of temperature profiles during freezing and dimension of ice crystals being formed. Mathematical description of the drying phase of freeze-drying is also coupled with the results obtained by freezing models, thus providing a comprehensive characterization of the lyophilization process. In this framework, deep understanding of the phenomena involved is required, and according to the Quality by Design approach, this knowledge can be used to build the design space. The step-by-step procedure for building the design space for freezing is thus described, and examples of applications are provided. The calculated design space is validated upon experimental data, and we show that it allows easy control of the freezing process and fast selection of appropriate operating conditions. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  9. The Influence of the Design of Web Survey Questionnaires on the Quality of Responses

    Directory of Open Access Journals (Sweden)

    Stéphane Ganassali

    2008-03-01

    Full Text Available he first objective of this article is to propose a conceptual framework of the effects of on-line questionnaire design on the quality of collected responses. Secondly, we present the results of an experiment where different protocols have been tested and compared in a randomised design using the basis of several quality indexes. Starting from some previous categorizations, and from the main factors identified in the literature, we first propose an initial global framework of the questionnaire and question characteristics in a web survey, divided into five groups of factors. Our framework was built to follow the response process successive stages of the contact between the respondent and the questionnaire itself. Then, because it has been studied in the survey methodology literature in a very restricted way, the concept of `response quality' is discussed and extended with some more `qualitative' criteria that could be helpful for researchers and practitioners, in order to obtain a deeper assessment of the survey output. As an experiment, on the basis of the factors chosen as major characteristics of the questionnaire design, eight versions of a questionnaire related to young people's consumption patterns were created. The links to these on-line questionnaires were sent in November 2005 to a target of 10,000 young people. The article finally presents the results of our study and discusses the conclusions. Very interesting results come to light; especially regarding the influence of length, interaction and question wording dimensions on response quality. We discuss the effects of Web-questionnaire design characteristics on the quality of data.

  10. Implementation of Quality by Design for Formulation of Rebamipide Gastro-retentive Tablet.

    Science.gov (United States)

    Ha, Jung-Myung; Seo, Jeong-Woong; Kim, Su-Hyeon; Kim, Ju-Young; Park, Chun-Woong; Rhee, Yun-Seok; Park, Eun-Seok

    2017-11-01

    The purpose of the present study was to develop a rebamipide (RBM) gastro-retentive (GR) tablet by implementing quality by design (QbD). RBM GR tablets were prepared using a sublimation method. Quality target product profile (QTPP) and critical quality attributes (CQAs) of the RBM GR tablets were defined according to the preliminary studies. Factors affecting the CQAs were prioritized using failure mode and effects analysis (FMEA). Design space and optimum formulation were established through a mixture design. The validity of the design space was confirmed using runs within the area. The QTPP of the RBM GR tablets was the orally administered GR tablet containing 300 mg of RBM taken once daily. Based on the QTPP, dissolution rate, tablet friability, and floating property were chosen as CQAs. According to the risk assessment, the amount of sustained-release agent, sublimating material, and diluent showed high-risk priority number (RPN) values above 40. Based on the RPN, these factors were further investigated using mixture design methodology. Design space of formulations was depicted as an overlaid contour plot and the optimum formulation to satisfy the desired responses was obtained by determining the expected value of each response. The similarity factor (f2) of the release profile between predicted response and experimental response was 89.463, suggesting that two release profiles are similar. The validity of the design space was also confirmed. Consequently, we were able to develop the RBM GR tablets by implementing the QbD concept. These results provide useful information for development of tablet formulations using the QbD.

  11. Design of a phantom multitrous for a gamma camera quality control

    International Nuclear Information System (INIS)

    Ben Krir, Wafa; Ben Ameur, Narjes

    2009-01-01

    In this study we presented the technique of scintigraphy in its various theoretical and practical aspects. We have also shown the importance the quality control procedure according to international standards, as NEMA. Starting from different phantoms currently used, developed according to standards, we designed our phantom. On the other part, this implementation has helped to highlight our expectations in Concerning the functionality of the phantom. Indeed, these results were very conclusive since they made it possible to make a very fast cost and quality control without ambiguity lower. We have thus proved the very advanced stage of reliability of our phantom.

  12. Quantifying the Impact of Feedstock Quality on the Design of Bioenergy Supply Chain Networks

    Directory of Open Access Journals (Sweden)

    Krystel K. Castillo-Villar

    2016-03-01

    Full Text Available Logging residues, which refer to the unused portions of trees cut during logging, are important sources of biomass for the emerging biofuel industry and are critical feedstocks for the first-type biofuel facilities (e.g., corn-ethanol facilities. Logging residues are under-utilized sources of biomass for energetic purposes. To support the scaling-up of the bioenergy industry, it is essential to design cost-effective biofuel supply chains that not only minimize costs, but also consider the biomass quality characteristics. The biomass quality is heavily dependent upon the moisture and the ash contents. Ignoring the biomass quality characteristics and its intrinsic costs may yield substantial economic losses that will only be discovered after operations at a biorefinery have begun. This paper proposes a novel bioenergy supply chain network design model that minimizes operational costs and includes the biomass quality-related costs. The proposed model is unique in the sense that it supports decisions where quality is not unrealistically assumed to be perfect. The effectiveness of the proposed methodology is proven by assessing a case study in the state of Tennessee, USA. The results demonstrate that the ash and moisture contents of logging residues affect the performance of the supply chain (in monetary terms. Higher-than-target moisture and ash contents incur in additional quality-related costs. The quality-related costs in the optimal solution (with final ash content of 1% and final moisture of 50% account for 27% of overall supply chain cost. Based on the numeral experimentation, the total supply chain cost increased 7%, on average, for each additional percent in the final ash content.

  13. Developing a quality by design approach to model tablet dissolution testing: an industrial case study.

    Science.gov (United States)

    Yekpe, Ketsia; Abatzoglou, Nicolas; Bataille, Bernard; Gosselin, Ryan; Sharkawi, Tahmer; Simard, Jean-Sébastien; Cournoyer, Antoine

    2017-11-02

    This study applied the concept of Quality by Design (QbD) to tablet dissolution. Its goal was to propose a quality control strategy to model dissolution testing of solid oral dose products according to International Conference on Harmonization guidelines. The methodology involved the following three steps: (1) a risk analysis to identify the material- and process-related parameters impacting the critical quality attributes of dissolution testing, (2) an experimental design to evaluate the influence of design factors (attributes and parameters selected by risk analysis) on dissolution testing, and (3) an investigation of the relationship between design factors and dissolution profiles. Results show that (a) in the case studied, the two parameters impacting dissolution kinetics are active pharmaceutical ingredient particle size distributions and tablet hardness and (b) these two parameters could be monitored with PAT tools to predict dissolution profiles. Moreover, based on the results obtained, modeling dissolution is possible. The practicality and effectiveness of the QbD approach were demonstrated through this industrial case study. Implementing such an approach systematically in industrial pharmaceutical production would reduce the need for tablet dissolution testing.

  14. Development of a Premium Quality Plasma-derived IVIg (IQYMUNE®) Utilizing the Principles of Quality by Design-A Worked-through Case Study.

    Science.gov (United States)

    Paolantonacci, Philippe; Appourchaux, Philippe; Claudel, Béatrice; Ollivier, Monique; Dennett, Richard; Siret, Laurent

    2018-01-01

    Polyvalent human normal immunoglobulins for intravenous use (IVIg), indicated for rare and often severe diseases, are complex plasma-derived protein preparations. A quality by design approach has been used to develop the Laboratoire Français du Fractionnement et des Biotechnologies new-generation IVIg, targeting a high level of purity to generate an enhanced safety profile while maintaining a high level of efficacy. A modular approach of quality by design was implemented consisting of five consecutive steps to cover all the stages from the product design to the final product control strategy.A well-defined target product profile was translated into 27 product quality attributes that formed the basis of the process design. In parallel, a product risk analysis was conducted and identified 19 critical quality attributes among the product quality attributes. Process risk analysis was carried out to establish the links between process parameters and critical quality attributes. Twelve critical steps were identified, and for each of these steps a risk mitigation plan was established.Among the different process risk mitigation exercises, five process robustness studies were conducted at qualified small scale with a design of experiment approach. For each process step, critical process parameters were identified and, for each critical process parameter, proven acceptable ranges were established. The quality risk management and risk mitigation outputs, including verification of proven acceptable ranges, were used to design the process verification exercise at industrial scale.Finally, the control strategy was established using a mix, or hybrid, of the traditional approach plus elements of the quality by design enhanced approach, as illustrated, to more robustly assign material and process controls and in order to securely meet product specifications.The advantages of this quality by design approach were improved process knowledge for industrial design and process

  15. The robust design for improving crude palm oil quality in Indonesian Mill

    Science.gov (United States)

    Maretia Benu, Siti; Sinulingga, Sukaria; Matondang, Nazaruddin; Budiman, Irwan

    2018-04-01

    This research was conducted in palm oil mill in Sumatra Utara Province, Indonesia. Currently, the main product of this mill is Crude Palm Oil (CPO) and hasn’t met the expected standard quality. CPO is the raw material for many fat derivative products. The generally stipulated quality criteria are dirt count, free fatty acid, and moisture of CPO. The aim of this study is to obtain the optimal setting for factor’s affect the quality of CPO. The optimal setting will result in an improvement of product’s quality. In this research, Experimental Design with Taguchi Method is used. Steps of this method are identified influence factors, select the orthogonal array, processed data using ANOVA test and signal to noise ratio, and confirmed the research using Quality Loss Function. The result of this study using Taguchi Method is to suggest to set fruit maturity at 75.4-86.9%, digester temperature at 95°C and press at 21 Ampere to reduce quality deviation until 42.42%.

  16. Coupled, parabolic-marching method for the prediction of three-dimensional viscous incompressible turbomachinery flows. Doctoral thesis

    Energy Technology Data Exchange (ETDEWEB)

    Kirtley, K.R.

    1988-10-01

    A new coupled parabolic-marching method was developed to solve the three-dimensional incompressible Navier-Stokes equation for turbulent turbomachinery flows. Earlier space-marching methods were analyzed to determine their global stability during multiple passes of the computational domain. The methods were found to be unconditionally unstable even when an extra equation for the pressure, namely the Poisson equation for the pressure, was used between passes of the domain. Relaxation of one constraint during the solution process was found to be necessary for the successful calculation of a complex flow.Thus, the method of pseudocompressibility was introduced into the partially parabolized Navier-Stokes equation to relax the mass flow constraint during a forward-marching integration as well as globally stable during successive passes of the domain. With consistent discretization, the new method was found to be convergent.

  17. Choosing a Cluster Sampling Design for Lot Quality Assurance Sampling Surveys.

    Directory of Open Access Journals (Sweden)

    Lauren Hund

    Full Text Available Lot quality assurance sampling (LQAS surveys are commonly used for monitoring and evaluation in resource-limited settings. Recently several methods have been proposed to combine LQAS with cluster sampling for more timely and cost-effective data collection. For some of these methods, the standard binomial model can be used for constructing decision rules as the clustering can be ignored. For other designs, considered here, clustering is accommodated in the design phase. In this paper, we compare these latter cluster LQAS methodologies and provide recommendations for choosing a cluster LQAS design. We compare technical differences in the three methods and determine situations in which the choice of method results in a substantively different design. We consider two different aspects of the methods: the distributional assumptions and the clustering parameterization. Further, we provide software tools for implementing each method and clarify misconceptions about these designs in the literature. We illustrate the differences in these methods using vaccination and nutrition cluster LQAS surveys as example designs. The cluster methods are not sensitive to the distributional assumptions but can result in substantially different designs (sample sizes depending on the clustering parameterization. However, none of the clustering parameterizations used in the existing methods appears to be consistent with the observed data, and, consequently, choice between the cluster LQAS methods is not straightforward. Further research should attempt to characterize clustering patterns in specific applications and provide suggestions for best-practice cluster LQAS designs on a setting-specific basis.

  18. Choosing a Cluster Sampling Design for Lot Quality Assurance Sampling Surveys.

    Science.gov (United States)

    Hund, Lauren; Bedrick, Edward J; Pagano, Marcello

    2015-01-01

    Lot quality assurance sampling (LQAS) surveys are commonly used for monitoring and evaluation in resource-limited settings. Recently several methods have been proposed to combine LQAS with cluster sampling for more timely and cost-effective data collection. For some of these methods, the standard binomial model can be used for constructing decision rules as the clustering can be ignored. For other designs, considered here, clustering is accommodated in the design phase. In this paper, we compare these latter cluster LQAS methodologies and provide recommendations for choosing a cluster LQAS design. We compare technical differences in the three methods and determine situations in which the choice of method results in a substantively different design. We consider two different aspects of the methods: the distributional assumptions and the clustering parameterization. Further, we provide software tools for implementing each method and clarify misconceptions about these designs in the literature. We illustrate the differences in these methods using vaccination and nutrition cluster LQAS surveys as example designs. The cluster methods are not sensitive to the distributional assumptions but can result in substantially different designs (sample sizes) depending on the clustering parameterization. However, none of the clustering parameterizations used in the existing methods appears to be consistent with the observed data, and, consequently, choice between the cluster LQAS methods is not straightforward. Further research should attempt to characterize clustering patterns in specific applications and provide suggestions for best-practice cluster LQAS designs on a setting-specific basis.

  19. Northern Great Plains Network water quality monitoring design for tributaries to the Missouri National Recreational River

    Science.gov (United States)

    Rowe, Barbara L.; Wilson, Stephen K.; Yager, Lisa; Wilson, Marcia H.

    2013-01-01

    The National Park Service (NPS) organized more than 270 parks with important natural resources into 32 ecoregional networks to conduct Inventory and Monitoring (I&M) activities for assessment of natural resources within park units. The Missouri National Recreational River (NRR) is among the 13 parks in the NPS Northern Great Plain Network (NGPN). Park managers and NGPN staff identified surface water resources as a high priority vital sign to monitor in park units. The objectives for the Missouri NRR water quality sampling design are to (1) assess the current status and long-term trends of select water quality parameters; and (2) document trends in streamflow at high-priority stream systems. Due to the large size of the Missouri River main stem, the NGPN water quality design for the Missouri NRR focuses on wadeable tributaries within the park unit. To correlate with the NGPN water quality protocols, monitoring of the Missouri NRR consists of measurement of field core parameters including dissolved oxygen, pH, specific conductance, and temperature; and streamflow. The purpose of this document is to discuss factors examined for selection of water quality monitoring on segments of the Missouri River tributaries within the Missouri NRR.Awareness of the complex history of the Missouri NRR aids in the current understanding and direction for designing a monitoring plan. Historical and current monitoring data from agencies and entities were examined to assess potential NGPN monitoring sites. In addition, the U.S. Environmental Protection Agency 303(d) list was examined for the impaired segments on tributaries to the Missouri River main stem. Because major tributaries integrate water quality effects from complex combinations of land use and environmental settings within contributing areas, a 20-mile buffer of the Missouri NRR was used to establish environmental settings that may impact the water quality of tributaries that feed the Missouri River main stem. For selection of

  20. Conceptual design of a regional water quality screening model. [RFF; Reach; HANFORD; ARQUAL; SEAS; NASQUAN

    Energy Technology Data Exchange (ETDEWEB)

    Davis, M J

    1981-01-01

    This water quality assessment methodology is intended to predict concentrations at future times and to estimate the impacts on water quality of energy-related activities (including industrial boilers). Estimates of impacts on water quality at future times are based on incremental changes in pollutant inputs to the body water. Important features of the model are: use of measured concentrations to account for existing conditions; consideration of incremental changes in pollutant loads; emphasis on the energy sector and industrial boilers; analysis restricted to streams only; no attempt to fully account for pollutant behavior; and flexible design, so that future improvements can be incorporated. The basic approach is very similar to the one used by Argonne's ARQUAL model but will allow more complex pollutant behavior and more flexibility in use. (PSB)

  1. Quality at the source (QATS) system design under six sigma methodology

    Energy Technology Data Exchange (ETDEWEB)

    Aguirre, F; Ballasteros, I; Maricalva, J [Emperesa Nacional del Uranio, S.A. (ENUSA), Nuclear Fuel Manufacturing Plant, Juzbado, Salamanca (Spain)

    2000-07-01

    One of the main objectives in the manufacturing of fuel assemblies, is to fulfill the customer expectations with a product that assures its reliability during its stay in the NPP. By mean of the QATS System design under 6-Sigma methodology, all the customer requirements are included in the product specifications and drawings. Product characteristics and process variables are classified and process capability is evaluated. All this information permits to identify CTQ's (Critical to Quality) product characteristics and process variables, and to define a quality system (QATS) based in the process and on-line characteristics control handled by the manufacturing workers. At the end, this system ensures a continuous product quality improvement, and a strong commitment with the customer requirements. (author)

  2. Quality at the source (QATS) system design under six sigma methodology

    International Nuclear Information System (INIS)

    Aguirre, F.; Ballasteros, I.; Maricalva, J.

    2000-01-01

    One of the main objectives in the manufacturing of fuel assemblies, is to fulfill the customer expectations with a product that assures its reliability during its stay in the NPP. By mean of the QATS System design under 6-Sigma methodology, all the customer requirements are included in the product specifications and drawings. Product characteristics and process variables are classified and process capability is evaluated. All this information permits to identify CTQ's (Critical to Quality) product characteristics and process variables, and to define a quality system (QATS) based in the process and on-line characteristics control handled by the manufacturing workers. At the end, this system ensures a continuous product quality improvement, and a strong commitment with the customer requirements. (author)

  3. Quality uncertainty and allocation of decision rights in the European protected designation of origin

    Directory of Open Access Journals (Sweden)

    Gaetano Martino

    2013-06-01

    Full Text Available The paper considers some issue in the governance of the European Protected Designation of Origin (PDO. The PDO systems are the outcomes of both farmers and consumers expectations and connect the valorisation of the agricultural and rural resources of given territories to the quality of typical products. A critical point in the governance of the PDO systems is represented by the connection between the quality strategies and the uncertainty. The paper argues that the PDO systems can be thought of as strictly coordinated subsystems in which the ex post governance play a critical role in coping with quality uncertainty. The study suggests that the society's inducements given raise to complex organizational systems in which the allocation of decision rights to PDO collective organizations play a major role. The empirical analysis is carried out by examining ten Italian PDO systems in order to identify the decision rights allocated.

  4. A design technique of low cost but high quality peak stretcher

    Energy Technology Data Exchange (ETDEWEB)

    Lo, H Y; Su, C S; Hsu, J Y; Wang, L

    1981-03-01

    This paper presents the design of low cost but high quality pulse peak stretcher incorporated with a LSI of 12 bit ADC and SKD-85 microcomputer. The conflict between the capacitor high charging speed and longer holding time for realizing a high quality stretcher is discussed and solved. For a lager number of channels available in a dual ramp Wilkinson-type ADC, two-stage stretchers connected in series are designed. The first stage is a fast-discharge to keep the output stretched pulse follow-up the input quickly and the second-stage (main stretcher) is a slow-discharge to keep the transient of the circuit minimum. Both of these two peak stretchers are described and the experiment results are photographically recorded.

  5. A Lagrangian parcel based mixing plane method for calculating water based mixed phase particle flows in turbo-machinery

    Science.gov (United States)

    Bidwell, Colin S.

    2015-05-01

    A method for calculating particle transport through turbo-machinery using the mixing plane analogy was developed and used to analyze the energy efficient engine . This method allows the prediction of temperature and phase change of water based particles along their path and the impingement efficiency and particle impact property data on various components in the engine. This methodology was incorporated into the LEWICE3D V3.5 software. The method was used to predict particle transport in the low pressure compressor of the . The was developed by NASA and GE in the early 1980s as a technology demonstrator and is representative of a modern high bypass turbofan engine. The flow field was calculated using the NASA Glenn ADPAC turbo-machinery flow solver. Computations were performed for a Mach 0.8 cruise condition at 11,887 m assuming a standard warm day for ice particle sizes of 5, 20 and 100 microns and a free stream particle concentration of . The impingement efficiency results showed that as particle size increased average impingement efficiencies and scoop factors increased for the various components. The particle analysis also showed that the amount of mass entering the inner core decreased with increased particle size because the larger particles were less able to negotiate the turn into the inner core due to particle inertia. The particle phase change analysis results showed that the larger particles warmed less as they were transported through the low pressure compressor. Only the smallest 5 micron particles were warmed enough to produce melting with a maximum average melting fraction of 0.18. The results also showed an appreciable amount of particle sublimation and evaporation for the 5 micron particles entering the engine core (22.6 %).

  6. Numerical simulation and modeling of the unsteady flow in turbomachinery; Numerische Simulation und Modellierung der instationaeren Stroemung in Turbomaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Eulitz, F

    2000-04-01

    The present work is devoted to the development of a computational technique for the Reynolds-averaged, time-resolved simulation of the undsteady, viscous flow in turbomachinery. After identification of model criteria, a novel turbulence and transition model, based on the extension of a one-equation turbulence model, is derived in order to incorporate the Reynolds-averaged effects of boundary-layer transition in unsteady turbomachinery flow. Preserving low numerical dissipation and dispersion errors, the explicit time integration method is accelerated through a time-consistent two-grid approach to allow for an efficient use of parallel computers. The model development is carefully assessed by considering various test cases of steady and unsteady turbine flow with various transition modes or of transonic channel flow with self-excited shock-oscillation. The application of the computational technique is demonstrated for the case of a single-stage, transonic compressor component and of a three-stage low-pressure turbine at low Reynolds-number operation. (orig.) [German] In dieser Arbeit wird ein numerisches Verfahren zur zeitgenauen Simulation der instationaeren, reibungsbehafteten Stroemung in Turbomaschinen auf Grundlage der Reynolds-gemittelten Navier-Stokes-Gleichungen entwickelt. Nach Aufarbeitung der Modellierungsanforderungen wird basierend auf einem Eingleichungsturbulenzmodell ein neuartiges Turbulenz- und Transitionsmodell abgeleitet, mit dem verschiedene Transitionsmoden der instationaeren Turbomaschinenstroemung in ihrer Reynolds-gemittelten Wirkung beschrieben werden koennen. Durch einen zeitkonsistenten Zweigitter-Ansatz wird die Zeitintegration fuer Navier-Stokes-Simulationen auf Parallelrechnern unter Wahrung geringer numerischer Phasen- und Amplitudenfehler beschleunigt. Die Entwicklung wird an einer Reihe von Testfaellen, zur stationaeren und instationaeren Turbinenstroemung mit unterschiedlicher Grenzschichttransition oder zur transsonischen

  7. [Design and implementation of a questionnaire to evaluate the dietary quality of school meals].

    Science.gov (United States)

    de Mateo Silleras, Beatriz; Camina Martín, M Alicia; Ojeda Sainz, Berta; Carreño Enciso, Laura; de la Cruz Marcos, Sandra; Marugán de Miguelsanz, José Manuel; Redondo del Río, Paz

    2014-10-03

    The school canteen provides a substantial proportion of the daily nutritional intake for many children. There are nutritional standards for school meals, however, it is still difficult to assess the dietary quality. To design a questionnaire for assessing the dietary quality of school meals, quickly and easily. A dietary questionnaire (COMES) was designed on the basis of the current recommendations. COMES consist of 15 items related to the food-frequency and to other characteristics of school meals. Then, a longitudinal prospective study was performed in order to analyze, with COMES, 36 school meals of 4 catering companies from Castilla y León during the academic years 2006-2007 to 2010-2011. Differences in dietary quality menus according to the management system of catering companies (in situ vs. transported) were analyzed by using the Mann-Whitney and the Kruskal-Wallis tests. The significance was reached at p culinary techniques were appropriate. No significant differences were found in the COMES score according to the management system (p=0,87), although catering system provides higher dietary quality. A new tool to assess quickly and easily the nutritional quality of school meals has been proposed. The assessment of the frequency intake of the most problematic foods for schoolchildren with this scale is much more demanding than the current recommendations. Even so, menus analyzed showed an acceptable quality in terms of variety of foods and culinary techniques, although milk frequency in the menus was excessive at the expense of fresh fruit. On the other hand, the transported system (i.e. catering, both hot and cold-holding) provides menus more consistent with the dietary recommendations. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  8. Quality Improvement Project to Improve Patient Satisfaction With Pain Management: Using Human-Centered Design.

    Science.gov (United States)

    Trail-Mahan, Tracy; Heisler, Scott; Katica, Mary

    2016-01-01

    In this quality improvement project, our health system developed a comprehensive, patient-centered approach to improving inpatient pain management and assessed its impact on patient satisfaction across 21 medical centers. Using human-centered design principles, a bundle of 6 individual and team nursing practices was developed. Patient satisfaction with pain management, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems pain composite score, increased from the 25th to just under the 75th national percentile.

  9. Design, construction and quality control of resistive-Micromegas anode boards for the ATLAS experiment

    Science.gov (United States)

    Kuger, F.; Iengo, P.

    2018-02-01

    For the upcoming upgrade of the forward muon stations of the ATLAS detector, 1280m2 of Micromegas chambers have to be constructed. The industrialization of anode board production is an essential precondition. Design and construction methods of these boards have been optimized towards mass production. In parallel quality control procedures have been developed and established. The first set of large size Micromegas anode boards has finally been produced in industries and demonstrates the feasibility of the project on full-scale.

  10. Indoor Air Quality in 24 California Residences Designed as High-Performance Homes

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mullen, Nasim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-07-01

    Today’s high performance green homes are reaching previously unheard of levels of airtightness and are using new materials, technologies and strategies, whose impacts on Indoor Air Quality (IAQ) cannot be fully anticipated from prior studies. This research study used pollutant measurements, home inspections, diagnostic testing and occupant surveys to assess IAQ in 24 new or deeply retrofitted homes designed to be high performance green buildings in California.

  11. Quality Control in Survey Design: Evaluating a Survey of Educators’ Attitudes Concerning Differentiated Compensation

    OpenAIRE

    Kelly D. Bradley; Michael Peabody; Shannon O. Sampson

    2015-01-01

    This study utilized the Rasch model to assess the quality of a survey instrument designed to measure attitudes of administrators and teachers concerning a differentiated teacher compensation program piloted in Kentucky.  Researchers addressing potentially contentious issues should ensure their methods stand up to rigorous criticism.  The results indicate that the rating scale does not function as expected, with items being too easy to endorse.  Future iterations of this survey should be revis...

  12. Application of quality function deployment to the design of a lithium battery

    Science.gov (United States)

    Halbleib, L.; Wormington, P.; Cieslak, W.; Street, H.

    Quality Function Deployment (QFD) is the tool we have selected to aid in the design, development and subsequent commercial manufacture of a Lithium/Thionyl Chloride 'D' cell for use in weapons applications. QFD is a structured methodology used to help assure that customer needs and expectations will be satisfied throughout the product life cycle. In this paper, we will describe our application of QFD, some of the lessons learned, and what we expect to be the final product of this QFD exercise.

  13. Quality Management, Environmental Management and Organizational Design in the Hotel Industry: A Qualitative Study

    OpenAIRE

    Tarí, Juan-José; Molina-Azorín, José F.; López-Gamero, María D.; Pereira-Moliner, Jorge; Pertusa-Ortega, Eva

    2014-01-01

    The purpose of this paper is twofold. First, the paper analyzes the relationship between quality management and environmental management and their effects on hotel performance. Second, the article examines the relationship between these two management systems and organizational design. The paper uses an exploratory, qualitative approach based on interviews with managers and experts in the hotel industry. Based on a content analysis of interviews, the results lead to several propositions. Spec...

  14. Establishment of quality, reliability and design standards for low, medium, and high power microwave hybrid microcircuits

    Science.gov (United States)

    Robinson, E. A.

    1973-01-01

    Quality, reliability, and design standards for microwave hybrid microcircuits were established. The MSFC Standard 85M03926 for hybrid microcircuits was reviewed and modifications were generated for use with microwave hybrid microcircuits. The results for reliability tests of microwave thin film capacitors, transistors, and microwave circuits are presented. Twenty-two microwave receivers were tested for 13,500 unit hours. The result of 111,121 module burn-in and operating hours for an integrated solid state transceiver module is reported.

  15. The 18 basic requirement of quality assurance for American design NPP

    International Nuclear Information System (INIS)

    Baliza, Ana Rosa

    2013-01-01

    On April 17th, 1969, the Atomic Energy Commission (AEC) published in the U.S. Federal Register (FR), Volume 34, Number 73, a proposed amendment to 10CFR50 to insert Appendix B - 'Quality assurance criteria for Nuclear Power Plant'. This Appendix was officially approved on June 27th, 1970 and published in the FR, volume 35, number 125. Appendix B is the Quality Assurance document for U.S. nuclear facilities. This document establishes eighteen basic requirements (BR) to design, construction, manufacture and operation of structures, systems and components (SSC) related to safety. The 18 BR describe 'what' shall be done, but not 'how' to do. In order to standardize the actions of nuclear facilities during 10 CFR 50 App B implementation, the industry has developed some documents, the main ones are: ASME NQA-1 (Quality Assurance Requirements for Nuclear Facility Applications) and the series ANSI N 45.2 (Quality Assurance Program Requirements for Nuclear Facilities). Both documents are approved by the NRC (Nuclear Regulatory Commission). The NRC is the licensing body of U.S. nuclear facilities. In Brazil, the licensing body is CNEN (Comissao Nacional de Energia Nuclear). This paper describes the 18 BR for American Designed Nuclear Power Plant (NPP), applicable to Angra-1 NPP. (author)

  16. Indoor air quality handbook: for designers, builders, and users of energy efficient residences

    International Nuclear Information System (INIS)

    1982-09-01

    The purpose of this handbook is to assist designers, builders, and users of energy efficient residences to achieve the goals of energy efficiency and maintenance of high indoor air quality simultaneously. The handbook helps in identifying and controlling potential problems of indoor air quality. It identifies sources and discusses effective ways to decrease concentrations of air contaminants. It focuses on indoor air quality in both single and multifamily energy-efficient residences. Information about commercial structures such as hospitals and office buildings is presented when it also applies to residences. Basic concepts of contaminants and their concentrations, sources and removal mechanisms, contaminant distribution, heat transfer, and air exchange are discussed. The effects of the building system on indoor air quality are examined. The effects of the external environment, building envelope, environmental control systems, interior design, furnishings, and inhabitants on the emission, dispersion, and removal of indoor air contaminants as well as direct and indirect effects of energy-efficient features are discussed. The health effects of specific air contaminants and the health standards developed for them are examined. Available methods for predicting and measuring contaminants and for evaluating human responses are discussed. Methods and equipment available for the control of indoor air pollution once the contaminants have been identified are also evaluated. The potential legal aspects, including regulatory intervention and civil lawsuits, of failure to evaluate and control indoor air pollution are discussed. A list of references, a glossary, and an index are also included

  17. Shift work and quality of sleep: effect of working in designed dynamic light.

    Science.gov (United States)

    Jensen, Hanne Irene; Markvart, Jakob; Holst, René; Thomsen, Tina Damgaard; Larsen, Jette West; Eg, Dorthe Maria; Nielsen, Lisa Seest

    2016-01-01

    To examine the effect of designed dynamic light on staff's quality of sleep with regard to sleep efficiency, level of melatonin in saliva, and subjective perceptions of quality of sleep. An intervention group working in designed dynamic light was compared with a control group working in ordinary institutional light at two comparable intensive care units (ICUs). The study included examining (1) melatonin profiles obtained from saliva samples, (2) quality of sleep in terms of sleep efficiency, number of awakenings and subjective assessment of sleep through the use of sleep monitors and sleep diaries, and (3) subjective perceptions of well-being, health, and sleep quality using a questionnaire. Light conditions were measured at both locations. A total of 113 nurses (88 %) participated. There were no significant differences between the two groups regarding personal characteristics, and no significant differences in total sleep efficiency or melatonin level were found. The intervention group felt more rested (OR 2.03, p = 0.003) and assessed their condition on awakening as better than the control group (OR 2.35, p = 0.001). Intervention-ICU nurses received far more light both during day and evening shifts compared to the control-ICU. The study found no significant differences in monitored sleep efficiency and melatonin level. Nurses from the intervention-ICU subjectively assessed their sleep as more effective than participants from the control-ICU.

  18. Design of environmental decision support system and its application to water quality management

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    EDSS is a comprehensive software system for water quality management in tidal river networks in general and for the Pearl River Delta in particular. Its purpose is to provide a practical tool that could assist government agencies in decision making for the efficient management of water resources in terms of both quantity and quality. By combining the capabilities of geographical information system (GIS), database management system (DBMS), model base management system (MBMS) and expert system, the aim is to improve the quality of decision making in what is becoming an increasingly complex area. This paper first outlines the basic concepts and philosophy adopted in developing EDSS, the system architecture, design features, implementation techniques and facilities provided. Thereafter, the core part of the system the hydrodynamic and water quality models are described briefly. The final contribution in this paper describes the application of EDSS to the Pearl River Delta, which has the most complicated tidal river network patterns as well as the fastest economic development in the world. Examples are given of the real-world problems that can be addressed using the system, including cross-boundary water pollution analysis, regional drinking water take-up site selection, screening of important polluters, environmental impact assessment, and water quality zoning and planning. It is illustrated that EDSS can provide efficient and scientific analytical tools for planning and decision-making purposes in the information era.

  19. DESIGN OF DYNAMIC VOLTAGE RESTORER TO ENHANCE POWER QUALITY RELYING ON RENEWABLE SOURCE

    Directory of Open Access Journals (Sweden)

    Haider M. Umran

    2018-05-01

    Full Text Available Power quality improvement of low voltage grid is a great challenge that confronts the sophisticated power applications, because their performance is highly sensitive to the quality of power supply. Dynamic Voltage Restorer (DVR used widely as an efficient and skillful device to adjust electrical disturbances of the distribution grids. This paper introduces an overview of the components of the 3-phase dynamic voltage restorer and design its own control circuit. The performance of DVR was developed on the basis of the appropriate selection of Photovoltaic (PV module instead of the present conventional designs. Through this design, the need of series converter (DVR for the current from an electrical grid will end and the problems of power losses will curb. The PV-module is selected to meet the requirements of the DVR during voltage sag/swell on voltage line. The proposed system is mimicked in MATLAB software/Simulink and the findings are presented to prove the success of the design in terms of: Full congruence of the load voltage waveform with source voltage waveform, attaining 0.77% of THD analysis for the load voltage and the waveforms of PV system.

  20. Integrating Kano’s Model into Quality Function Deployment for Product Design: A Comprehensive Review

    Science.gov (United States)

    Ginting, Rosnani; Hidayati, Juliza; Siregar, Ikhsan

    2018-03-01

    Many methods and techniques are adopted by some companies to improve the competitiveness through the fulfillment of customer satisfaction by enhancement and improvement the product design quality. Over the past few years, several researcher have studied extensively combining Quality Function Deployment and Kano’s model as design techniques by focusing on translating consumer desires into a product design. This paper presents a review and analysis of several literatures that associated to the integration methodology of Kano into the QFD process. Various of international journal articles were selected, collected and analyzed through a number of relevant scientific publications. In-depth analysis was performed, and focused in this paper on the results, advantages and drawbacks of its methodology. In addition, this paper also provides the analysis that acquired in this study related to the development of the methodology. It is hopedd this paper can be a reference for other researchers and manufacturing companies to implement the integration method of QFD- Kano for product design.

  1. Quality by Design approach to spray drying processing of crystalline nanosuspensions.

    Science.gov (United States)

    Kumar, Sumit; Gokhale, Rajeev; Burgess, Diane J

    2014-04-10

    Quality by Design (QbD) principles were explored to understand spray drying process for the conversion of liquid nanosuspensions into solid nano-crystalline dry powders using indomethacin as a model drug. The effects of critical process variables: inlet temperature, flow and aspiration rates on critical quality attributes (CQAs): particle size, moisture content, percent yield and crystallinity were investigated employing a full factorial design. A central cubic design was employed to generate the response surface for particle size and percent yield. Multiple linear regression analysis and ANOVA were employed to identify and estimate the effect of critical parameters, establish their relationship with CQAs, create design space and model the spray drying process. Inlet temperature was identified as the only significant factor (p value dried nano-crystalline powders. Aspiration and flow rates were identified as significant factors affecting yield (p value dried at higher inlet temperatures had lower moisture compared to those dried at lower inlet temperatures. Published by Elsevier B.V.

  2. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study.

    Science.gov (United States)

    Tabrizi, Jafar-Sadegh; Farahbakhsh, Mostafa; Shahgoli, Javad; Rahbar, Mohammad Reza; Naghavi-Behzad, Mohammad; Ahadi, Hamid-Reza; Azami-Aghdash, Saber

    2015-10-01

    Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models). Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country. Designed primary model (8 criteria, 55 sub-criteria, and 236 standards) were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality.

  3. Credible checklists and quality questionnaires a user-centered design method

    CERN Document Server

    Wilson, Chauncey

    2013-01-01

    Credible Checklists and Quality Questionnaires starts off with an examination of the critical but commonly overlooked checklist method. In the second chapter, questionnaires and surveys are discussed. Asking questions sounds simple, but the hard truth is that asking questions (and designing questionnaires) is a difficult task. This chapter discusses being mindful of the choice of words, order of questions and how early questions influence later questions, answer scales and how they impact the user response, questionnaire design, and much more. The final chapter provides examples of some common questionnaires (both free and fee-based) for assessing the usability of products. After reading this book, readers will be able to use these user design tools with greater confidence and certainty.

  4. Universal Design as a Booster for Housing Quality and Architectural Practice.

    Science.gov (United States)

    Denizou, Karine

    2016-01-01

    Norwegian central government has for the last decade increasingly focused on universal design. Fundamental changes in the Norwegian building code and corresponding regulations in 2010 give an apparently clear framework for the implementation of accessibility and universal design. However, it seems that neither increased awareness of accessibility requirements and universal design, nor compliance with the building code guarantees improvement of housing quality and usability. The Norwegian regulations have gone further in the direction of performance requirements than most other countries. This applies to all types of requirements, including requirements for usability, functionality and accessibility. Hardly any specifications are to be found in the regulations. Ideally, this lack of specifications should give designers the opportunity to develop innovative answers and hence to respond to different contexts and needs. Still, many architects and builders ask for clear specifications, in order to simplify and speed up design processes and make control of solutions easier. Many architects understand guidelines as minimum requirements, and are thus reproducing the identical solutions without considering the context and the needs of the users. They see accessibility as another regulatory pressure and requirements as restrictions rather than positive incentives. However, there are examples of designers who have internalised the regulatory framework and thus are able to create and integrate inclusive design in their daily work. Based on recent research conducted by SINTEF Building and Infrastructure and financed by the Norwegian State Housing Bank, this paper presents examples of practice where dwellings have been developed within a framework of universal design. Focus of the research has been on the approach of the design team and their understanding and use of the regulatory framework in order to create better homes in dialogue with the building authorities. Main

  5. Applying quality by design (QbD) concept for fabrication of chitosan coated nanoliposomes.

    Science.gov (United States)

    Pandey, Abhijeet P; Karande, Kiran P; Sonawane, Raju O; Deshmukh, Prashant K

    2014-03-01

    In the present investigation, a quality by design (QbD) strategy was successfully applied to the fabrication of chitosan-coated nanoliposomes (CH-NLPs) encapsulating a hydrophilic drug. The effects of the processing variables on the particle size, encapsulation efficiency (%EE) and coating efficiency (%CE) of CH-NLPs (prepared using a modified ethanol injection method) were investigated. The concentrations of lipid, cholesterol, drug and chitosan; stirring speed, sonication time; organic:aqueous phase ratio; and temperature were identified as the key factors after risk analysis for conducting a screening design study. A separate study was designed to investigate the robustness of the predicted design space. The particle size, %EE and %CE of the optimized CH-NLPs were 111.3 nm, 33.4% and 35.2%, respectively. The observed responses were in accordance with the predicted response, which confirms the suitability and robustness of the design space for CH-NLP formulation. In conclusion, optimization of the selected key variables will help minimize the problems related to size, %EE and %CE that are generally encountered when scaling up processes for NLP formulations. The robustness of the design space will help minimize both intra-batch and inter-batch variations, which are quite common in the pharmaceutical industry.

  6. Green design application on campus to enhance student’s quality of life

    Science.gov (United States)

    Tamiami, H.; Khaira, F.; Fachrudin, A.

    2018-02-01

    Green design becomes an important thing to applied in the building. Green building will provide comfortability and enhance Quality of Life (QoL) for the users. The purpose of this research is to analyze how green design application on campus to enhance student’s QoL. This research conducted in three campuses which located in North Sumatera Province, namely Universitas Sumatera Utara (USU), Universitas Negeri Medan (Unimed) and Universitas Medan Area (UMA) which have a lot of vegetation, open space, and multi-mass buildings. This research compared the green design application to QoL from three universities. Green design in this research that become independent variables focus on the energy efficiency and conservation (EEC), indoor health and comfort (IHC) and building environment management (BEM) with dependent variable is QoL. This research uses quantitative methods with questionnaire survey techniques. The population is students from the three universities with the sample of each University is 50 samples. The analysis uses multiple regression analysis. The results show that green design application may enhance QoL of students. The campus should have a good green design application to enhance QoL of students and give them comfortability.

  7. Re-design of apple pia packaging using quality function deployment method

    Science.gov (United States)

    Pulungan, M. H.; Nadira, N.; Dewi, I. A.

    2018-03-01

    This study was aimed to identify the attributes for premium apple pia packaging, to determine the technical response to be carried out by Permata Agro Mandiri Small and Medium Enterprise (SME) and to design a new apple pie packaging acceptable by the SME. The Quality Function Deployment (QFD) method was employed to improve the apple pia packaging design, which consisted of seven stages in data analysis. The results indicated that whats attribute required by the costumers include graphic design, dimensions, capacity, shape, strength, and resistance of packaging. While, the technical responses to be conducted by the SMEs were as follows: attractive visual packaging designs, attractive colors, clear images and information, packaging size dimensions, a larger capacity packaging (more product content), ergonomic premium packaging, not easily torn, and impact resistant packaging materials. The findings further confirmed that the design of premium apple pia packaging accepted by the SMES was the one with the capacity of ten apple pia or 200 g weight, and with rectangular or beam shape form. The packaging material used was a duplex carton with 400 grammage (g/m2), the outer part of the packaging was coated with plastic and the inside was added with duplex carton. The acceptable packaging dimension was 30 cm x 5 cm x 3 cm (L x W x H) with a mix of black and yellow color in the graphical design.

  8. A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation.

    Science.gov (United States)

    Aksu, Buket; Paradkar, Anant; de Matas, Marcel; Özer, Özgen; Güneri, Tamer; York, Peter

    2013-02-01

    Quality by design (QbD) is an essential part of the modern approach to pharmaceutical quality. This study was conducted in the framework of a QbD project involving ramipril tablets. Preliminary work included identification of the critical quality attributes (CQAs) and critical process parameters (CPPs) based on the quality target product profiles (QTPPs) using the historical data and risk assessment method failure mode and effect analysis (FMEA). Compendial and in-house specifications were selected as QTPPs for ramipril tablets. CPPs that affected the product and process were used to establish an experimental design. The results thus obtained can be used to facilitate definition of the design space using tools such as design of experiments (DoE), the response surface method (RSM) and artificial neural networks (ANNs). The project was aimed at discovering hidden knowledge associated with the manufacture of ramipril tablets using a range of artificial intelligence-based software, with the intention of establishing a multi-dimensional design space that ensures consistent product quality. At the end of the study, a design space was developed based on the study data and specifications, and a new formulation was optimized. On the basis of this formulation, a new laboratory batch formulation was prepared and tested. It was confirmed that the explored formulation was within the design space.

  9. Data path design and image quality aspects of the next generation multifunctional printer

    Science.gov (United States)

    Brassé, M. H. H.; de Smet, S. P. R. C.

    2008-01-01

    Multifunctional devices (MFDs) are increasingly used as a document hub. The MFD is used as a copier, scanner, printer, and it facilitates digital document distribution and sharing. This imposes new requirements on the design of the data path and its image processing. Various design aspects need to be taken into account, including system performance, features, image quality, and cost price. A good balance is required in order to develop a competitive MFD. A modular datapath architecture is presented that supports all the envisaged use cases. Besides copying, colour scanning is becoming an important use case of a modern MFD. The copy-path use case is described and it is shown how colour scanning can also be supported with a minimal adaptation to the architecture. The key idea is to convert the scanner data to an opponent colour space representation at the beginning of the image processing pipeline. The sub-sampling of chromatic information allows for the saving of scarce hardware resources without significant perceptual loss of quality. In particular, we have shown that functional FPGA modules from the copy application can also be used for the scan-to-file application. This makes the presented approach very cost-effective while complying with market conform image quality standards.

  10. Presentation of a quality organisation pattern for the design, manufacturing and implementation of complex measuring chains

    International Nuclear Information System (INIS)

    Hervault, V.; Piguet, M.

    1995-01-01

    The EFMT (Experience Feedback, Measures-Tests) branch of EDF Research and Development Division designs and installs instrumentation systems for power generation sites. These systems include either testing (thermal and mechanical operation surveys) or process control instruments. The context in which instrumentation is developed and used has much varied during the past few years from both technical and organisational viewpoint. An instrumentation system consists of a set of measuring chains associated to communication supports and an acquisition software; the technical knowledge involved are highly diversified: measurement, field bus, computing, data processing... Customers now include quality requirements in their specifications and often make reference to standards of the EN 29000 series. The EFMT Branch has defined a quality approach applicable to instrumentation field which aims at ensuring the technical success (namely to attain the expected characteristics) and meeting customers' quality requirements. This approach based upon project management techniques defines the design implementation and operating process phases. It emphasizes a global approach to instrumentation while promoting the communication between the partners in a project. This paper presents the whole approach and underlines its critical phases: users' requirements, testing and acceptance procedures. (authors). 5 refs., 2 figs., 1 tab

  11. A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design.

    Science.gov (United States)

    Martin-Moe, Sheryl; Lim, Fredric J; Wong, Rita L; Sreedhara, Alavattam; Sundaram, Jagannathan; Sane, Samir U

    2011-08-01

    Quality by design (QbD) is a science- and risk-based approach to drug product development. Although pharmaceutical companies have historically used many of the same principles during development, this knowledge was not always formally captured or proactively submitted to regulators. In recent years, the US Food and Drug Administration has also recognized the need for more controls in the drug manufacturing processes, especially for biological therapeutics, and it has recently launched an initiative for Pharmaceutical Quality for the 21st Century to modernize pharmaceutical manufacturing and improve product quality. In the biopharmaceutical world, the QbD efforts have been mainly focused on active pharmaceutical ingredient processes with little emphasis on drug product development. We present a systematic approach to biopharmaceutical drug product development using a monoclonal antibody as an example. The approach presented herein leverages scientific understanding of products and processes, risk assessments, and rational experimental design to deliver processes that are consistent with QbD philosophy without excessive incremental effort. Data generated using these approaches will not only strengthen data packages to support specifications and manufacturing ranges but hopefully simplify implementation of postapproval changes. We anticipate that this approach will positively impact cost for companies, regulatory agencies, and patients, alike. Copyright © 2011 Wiley-Liss, Inc.

  12. Analysis of the macroscopic mechanisms produced by rotor/stator interactions in turbomachinery; Analyse des mecanismes macroscopiques produits par les interactions rotot/stator dans les turbomachines

    Energy Technology Data Exchange (ETDEWEB)

    Callot, St.

    2002-01-15

    Unsteady phenomena produced by the relative motion between fixed and moving rows in turbomachinery is characterized by different scales in space and time. From the numerical point of view, taking into account those effects requires new models. The purpose of this work is a better understanding of the unsteady mechanisms in a multistage turbomachinery. In order to cast of any restricting hypothesis over the spatial periodicities, numerical simulations are operated over the whole circumference of each row. In the single stage case, it is shown that the unsteady flow presents a phase-lagged periodic condition which may be described by the double Fourier decomposition proposed by Tyler and Sofrin. The spatial modes precise the interaction between rows and a comparison is made with the Adamczyk's decomposition. The numerical simulation of a one and a half stage brings an extension of the analysis of the interactions in a multistage machine. (author)

  13. Adaptation of the quality by design concept in early pharmaceutical development of an intranasal nanosized formulation.

    Science.gov (United States)

    Pallagi, Edina; Ambrus, Rita; Szabó-Révész, Piroska; Csóka, Ildikó

    2015-08-01

    Regulatory science based pharmaceutical development and product manufacturing is highly recommended by the authorities nowadays. The aim of this study was to adapt regulatory science even in the nano-pharmaceutical early development. Authors applied the quality by design (QbD) concept in the early development phase of nano-systems, where the illustration material was meloxicam. The meloxicam nanoparticles produced by co-grinding method for nasal administration were studied according to the QbD policy and the QbD based risk assessment (RA) was performed. The steps were implemented according to the relevant regulatory guidelines (quality target product profile (QTPP) determination, selection of critical quality attributes (CQAs) and critical process parameters (CPPs)) and a special software (Lean QbD Software(®)) was used for the RA, which represents a novelty in this field. The RA was able to predict and identify theoretically the factors (e.g. sample composition, production method parameters, etc.) which have the highest impact on the desired meloxicam-product quality. The results of the practical research justified the theoretical prediction. This method can improve pharmaceutical nano-developments by achieving shorter development time, lower cost, saving human resource efforts and more effective target-orientation. It makes possible focusing the resources on the selected parameters and area during the practical product development. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. The comparison of laser surface designing and pigment printing methods for the product quality

    Science.gov (United States)

    Ozguney, Arif Taner

    2007-07-01

    Developing new designs by using the computer and transferring the designs that are obtained to textile surfaces will not only increase and facilitate the production in a more practical manner, but also help you create identical designs. This means serial manufacturing of the products at standard quality and increasing their added values. Moreover, creating textile designs using the laser will also contribute to the value of the product as far as the consumer is concerned because it will not cause any wearing off and deformation in the texture of the fabric unlike the other methods. In the system that has been designed, the laser beam at selected wavelength and intensity was directed onto a selected textile surface and a computer-controlled laser beam source was used to change the colour substances on the textile surface. Pigment printing is also used for designing in textile and apparel sector. In this method, designs are transferred to the fabric manually by using dyestuff. In this study, the denim fabric used for the surfacing trial was 100% cotton, with a weft count per centimeter of 20 and a warp count per centimeter of 27, with fabric weight of 458 g/m 2. The first step was to prepare 40 pieces of denim samples, half of which were prepared manually pigment printing and the other half by using the laser beam. After this, some test applications were done. The tensile strength, tensile extension and some fastness values of designed pieces with two methods were compared according to the international standards.

  15. Multi-board concept - a scenario based approach for supporting product quality and life cycle oriented design

    DEFF Research Database (Denmark)

    Robotham, Antony John; Hertzum, Morten

    2000-01-01

    This paper will describe the multi-board concept, which is a working approach for supporting life cycle oriented design and product quality. Aspects of this concept include construction of a common working environment where multiple display boards depict scenarios of the product life cycle...... to believe that the multi-board concept promises to be a useful means of communication amongst the design team. We be-lieve that it fosters a thorough understanding of life cycle events, which, in turn, inspires the design of innovative products of the highest quality......., creating a shared quality mindset amongst design-ers, and developing creativity and synthesis in product design. The appropriateness of scenarios for supporting life cycle oriented design will be ar-gued and preliminary results from early experi-mentation will be presented.Initial results lead us...

  16. Development and evaluation of paclitaxel nanoparticles using a quality-by-design approach.

    Science.gov (United States)

    Yerlikaya, Firat; Ozgen, Aysegul; Vural, Imran; Guven, Olgun; Karaagaoglu, Ergun; Khan, Mansoor A; Capan, Yilmaz

    2013-10-01

    The aims of this study were to develop and characterize paclitaxel nanoparticles, to identify and control critical sources of variability in the process, and to understand the impact of formulation and process parameters on the critical quality attributes (CQAs) using a quality-by-design (QbD) approach. For this, a risk assessment study was performed with various formulation and process parameters to determine their impact on CQAs of nanoparticles, which were determined to be average particle size, zeta potential, and encapsulation efficiency. Potential risk factors were identified using an Ishikawa diagram and screened by Plackett-Burman design and finally nanoparticles were optimized using Box-Behnken design. The optimized formulation was further characterized by Fourier transform infrared spectroscopy, X-ray diffractometry, differential scanning calorimetry, scanning electron microscopy, atomic force microscopy, and gas chromatography. It was observed that paclitaxel transformed from crystalline state to amorphous state while totally encapsulating into the nanoparticles. The nanoparticles were spherical, smooth, and homogenous with no dichloromethane residue. In vitro cytotoxicity test showed that the developed nanoparticles are more efficient than free paclitaxel in terms of antitumor activity (more than 25%). In conclusion, this study demonstrated that understanding formulation and process parameters with the philosophy of QbD is useful for the optimization of complex drug delivery systems. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

  17. Application of the non lineal dynamics to the design of processes in the administration of quality

    International Nuclear Information System (INIS)

    Domech More, Jesus

    1999-01-01

    The design of processes is a fundamental pillar inside a System of Total Administration of Quality. The great majority of the problems that you/they happen in an organization - 85% - they are caused by the processes, not for the employees. When the processes are not well designed the problems arise: errors, waste, losses of time, delays, duplication take place of the work, flaws of teams and in the worst cases, the client's dissatisfaction. This influences negatively in the Costs of Non conformity. In the work he/she thinks about the possibility to apply the techniques from the non lineal dynamics to the one design of processes like a complex but realer tool that the statistical techniques. As study object the process of production of lead containers is used (means of shielding) that are used to carry radioisotopes in the System of Health of Cuba. He/she intends a model of non lineal dynamics of the process that allows to evaluate what so predictable it is the chosen system (entrance Control to the matter prevails) and which the one will be behavior average of the same one based in the complex interactions that arise in the relationships client-supplier, operative-machine, supplier-supplier, operative-environment and operative-method. Each one of these interactions constitutes a source of uncertainty in the one. I process and he/she has a weight on the temporary dynamics of the characteristic of real quality (homogeneity of the shielding) in the process

  18. Spectrophotometric Quantification of Vilazodone Hydrochloride in Pharmaceutical Dosage Form Using Quality by Design Approach

    International Nuclear Information System (INIS)

    Panda, S.S.; Kumar, B.V.V.R.K.; Beg, S.; Behera, S.

    2015-01-01

    The present work deals with development and validation of a novel, robust, precise and accurate spectrophotometric method, for the estimation of vilazodone hydrochloride in tablets using the principle of Quality by Design (QbD). A fractional factorial design (FFD) was employed for initial parameter screening. Further the screened parameters were subjected to central composite design (CCD) for evaluating method robustness and method optimization. Different statistical parameters were evaluated to decide appropriateness of experimental data. Vilazodone shows absorption maximum at 285 nm using methanol. Factor screening slit width and sampling interval were identified as critical method variables, which were further evaluated by a CCD. Good linearity was obtained for vilazodone in the range of 5-60 μg/ mL with R"2 > 0.999. The method was found to be accurate with good average % recovery (more than 100 %). Developed method was validated as per ICH guidelines. Based on QbD development of spectrophotometric method ensured that quality is built into the method. The method was robust and can be applied for determination of the vilazodone in pharmaceutical dosage form. (author)

  19. Analysing the disposal of non-conformance in support and hunger design from the view of quality management

    International Nuclear Information System (INIS)

    Zhu Jianjun

    2008-01-01

    A serious non-conformance in the support and hunger design was found during the construction stage in a nuclear power project. In the view of quality management, the origin for the non-conformance is that the design process was not controlled properly and the design result was given without validation. Several experiences are summarized, such as the enhancement of the management level for various leaders and quality consciousness for all staff, the improvement of process management and training scheme, and paying more attention to the communication with the purchaser and the informationization construction in the design work, to ensure the traceability of the design and development. (author)

  20. Exploring simple assessment methods for lighting quality with architecture and design students

    DEFF Research Database (Denmark)

    Madsen, Merete

    2006-01-01

    that cannot be assessed by simple equations or rules-of-thumb. Balancing the many an often contradictory aspects of energy efficiency and high quality lighting design is a complex undertaking not just for students. The work described in this paper is one result of an academic staff exchange between...... the Schools of Architecture in Copenhagen and Victoria University of Wellington (New Zealand). The authors explore two approaches to teaching students simple assessment methods that can contribute to making more informed decisions about the luminous environment and its quality. One approach deals...... with the assessment of luminance ratios in relation to computer work and presents in that context some results from an experiment undertaken to introduce the concept of luminance ratios and preferred luminance ranges to architeture students. In the other approach a Danish method for assissing the luminance...

  1. Design of quality assurance surveillance of geotechnical investigation in evaluation of nuclear power plants siting

    International Nuclear Information System (INIS)

    Made Pramayuni; Haendra Subekti

    2011-01-01

    System of building Nuclear Power Plants (NPP) is built above ground surface and rocks. Therefore, the geotechnical aspects evaluation of NPP siting in particular must be implemented properly and accurately. The successful of the design and construction of the building system is influenced by geotechnical conditions in the vicinity of NPP will be built. To be able to perform geotechnical analysis is good and true; it's required data of surface/underground completely. These data can be obtained directly not only from the geotechnical field investigations, but also can be obtained from the laboratory tests results. To ensure that geotechnical investigations are conducted effectively and efficiently, produce accurate data, as well as meeting the requirements of safety, health, safety, environmental, quality and economic, then the Quality Assurance Program (QAP) should be established and implemented. Supervision of the QAP implementation is required to ensure the work is done according to QAP that have been established and applicable requirement. (author)

  2. Design and Analysis of Grid Connected Photovoltaic Fed Unified Power Quality Conditioner

    Science.gov (United States)

    Dash, Santanu Kumar; Ray, Pravat Kumar

    2016-06-01

    This paper proposes the integration scheme and operation of the Unified Power Quality conditioner (UPQC) with Photovoltaic source as distributed generations for power quality improvement. Thus, it provides a novel PV-grid integration configuration and prevents any adverse situation related to current or voltage in power system. Voltage related issues are maintained by the series part of UPQC and the current related issues are handles by shunt part of the UPQC. The various operation modes of PV-UPQC schemes are broadly classified according to the direction of power flow, (i) Interconnected mode, (ii) Islanding mode. PV-UPQC has advantage over the conventional UPQC scheme as it has developed the capability to compensate the voltage interruption problems Control algorithms for shunt and series part of the UPQC is implemented. Development of the proposed configuration has been designed in the laboratory with control algorithm implemented in dSPACE and results are discussed.

  3. IEA Project on Indoor Air Quality Design and Control in Low Energy Residential Buildings

    DEFF Research Database (Denmark)

    Rode, Carsten; Abadie, Marc; Qin, Menghao

    2016-01-01

    with heat recovery systems, one of the next focal points to limiting energy consumption for thermally conditioning the indoor environment will be to possibly reducing the ventilation rate, or to make it in a new way demand controlled. However, this must be done such that it has no have adverse effects...... on Indoor Air Quality (IAQ). Annex 68, Indoor Air Quality Design and Control in Low Energy Residential Buildings, is a project under IEA’s Energy Conservation in Buildings and Communities Program (EBC), which will endeavor to investigate how future residential buildings are able to have very high energy...... performance whilst providing comfortable and healthy indoor environments. New paradigms for demand control of ventilation will be investigated, which consider the pollution loads and occupancy in buildings. The thermal and moisture conditions of such will be considered because of interactions between...

  4. An International Project on Indoor Air Quality Design and Control in Low Energy Residential Buildings

    DEFF Research Database (Denmark)

    Rode, Carsten; Abadie, Marc; Qin, Menghao

    2016-01-01

    focal points to limiting energy consumption for thermally conditioning the indoor environment will be to possibly reducing the ventilation rate, or making it in a new way demand controlled. However, this must be done such that it does not have adverse effects on indoor air quality (IAQ). Annex 68......In order to achieve nearly net zero energy use, both new and energy refurbished existing buildings will in the future need to be still more efficient and optimized. Since such buildings can be expected to be already well insulated, airtight, and have heat recovery systems installed, one of the next......, Indoor Air Quality Design and Control in Low Energy Residential Buildings, is a project under IEA’s Energy Conservation in Buildings and Communities Program (EBC), which will endeavor to investigate how future residential buildings are able to have very high energy performance whilst providing...

  5. Customer Focused Product Design Using Integrated Model of Target Costing, Quality Function Deployment and Value Engineering

    Directory of Open Access Journals (Sweden)

    Hossein Rezaei Dolatabadi

    2013-01-01

    Full Text Available Target costing by integrating customer requirements, technical attributes and cost information into the product design phase and eliminating the non-value added functions, plays a vital role in different phases of the product life cycle. Quality Function Deployment (QFD and Value Engineering (VE are two techniques which can be used for applying target costing, successfully. The purpose of this paper is to propose an integrated model of target costing, QFD and VE to explore the role of target costing in managing product costs while promoting quality specifications meeting customers’ needs. F indings indicate that the integration of target costing, QFD and VE is an essential technique in managing the costs of production process. Findings also imply that integration of the three techniques provides a competitive cost advantage to companies.

  6. Incentive Design and Quality Improvements: Evidence from State Medicaid Nursing Home Pay-for-Performance Programs.

    Science.gov (United States)

    Konetzka, R Tamara; Skira, Meghan M; Werner, Rachel M

    2018-01-01

    Pay-for-performance (P4P) programs have become a popular policy tool aimed at improving health care quality. We analyze how incentive design affects quality improvements in the nursing home setting, where several state Medicaid agencies have implemented P4P programs that vary in incentive structure. Using the Minimum Data Set and the Online Survey, Certification, and Reporting data from 2001 to 2009, we examine how the weights put on various performance measures that are tied to P4P bonuses, such as clinical outcomes, inspection deficiencies, and staffing levels, affect improvements in those measures. We find larger weights on clinical outcomes often lead to larger improvements, but small weights can lead to no improvement or worsening of some clinical outcomes. We find a qualifier for P4P eligibility based on having few or no severe inspection deficiencies is more effective at decreasing inspection deficiencies than using weights, suggesting simple rules for participation may incent larger improvement.

  7. Virtual classroom design for Blended Learning: Human Development and Quality of Life

    Directory of Open Access Journals (Sweden)

    Juan Carlos Morales Intriago

    2017-03-01

    Full Text Available The explosive development in all areas of knowledge has evolved the scenarios of generation and transfer of knowledge, in terms of media, channels and supports, parallel to this appear new resources that optimize the processes of vocational training, whether formal, non-formal and informal. The EVA or Virtual Learning Environments evolve the traditional way of teaching a Blended environment, which is, combining classroom education with online training processes. The present work designs a training process set in Blended Learning for the subject Human Development and Quality of Life, summarizing in 8 steps the construction of the virtual and face-to-face environment, where starting from the common to the specific, the system is described systemically. The methodology applied in the present work was of Bibliographic and documentary type. To achieve the proposed objective, a systemic design was designed that divided the research into two stages: the exploration stage and the design stage. In the exploration stage, a large bibliographical collection was revised and in the design stage the virtual classroom model of the subject was constructed. Product of the investigation is a guide that guides step by step in the construction of virtual environments set in the Blended Learning.

  8. Quality by design case study: an integrated multivariate approach to drug product and process development.

    Science.gov (United States)

    Huang, Jun; Kaul, Goldi; Cai, Chunsheng; Chatlapalli, Ramarao; Hernandez-Abad, Pedro; Ghosh, Krishnendu; Nagi, Arwinder

    2009-12-01

    To facilitate an in-depth process understanding, and offer opportunities for developing control strategies to ensure product quality, a combination of experimental design, optimization and multivariate techniques was integrated into the process development of a drug product. A process DOE was used to evaluate effects of the design factors on manufacturability and final product CQAs, and establish design space to ensure desired CQAs. Two types of analyses were performed to extract maximal information, DOE effect & response surface analysis and multivariate analysis (PCA and PLS). The DOE effect analysis was used to evaluate the interactions and effects of three design factors (water amount, wet massing time and lubrication time), on response variables (blend flow, compressibility and tablet dissolution). The design space was established by the combined use of DOE, optimization and multivariate analysis to ensure desired CQAs. Multivariate analysis of all variables from the DOE batches was conducted to study relationships between the variables and to evaluate the impact of material attributes/process parameters on manufacturability and final product CQAs. The integrated multivariate approach exemplifies application of QbD principles and tools to drug product and process development.

  9. Using implementation tools to design and conduct quality improvement projects for faster and more effective improvement.

    Science.gov (United States)

    Ovretveit, John; Mittman, Brian; Rubenstein, Lisa; Ganz, David A

    2017-10-09

    Purpose The purpose of this paper is to enable improvers to use recent knowledge from implementation science to carry out improvement changes more effectively. It also highlights the importance of converting research findings into practical tools and guidance for improvers so as to make research easier to apply in practice. Design/methodology/approach This study provides an illustration of how a quality improvement (QI) team project can make use of recent findings from implementation research so as to make their improvement changes more effective and sustainable. The guidance is based on a review and synthesis of improvement and implementation methods. Findings The paper illustrates how research can help a quality project team in the phases of problem definition and preparation, in design and planning, in implementation, and in sustaining and spreading a QI. Examples of the use of different ideas and methods are cited where they exist. Research limitations/implications The example is illustrative and there is little limited experimental evidence of whether using all the steps and tools in the one approach proposed do enable a quality team to be more effective. Evidence supporting individual guidance proposals is cited where it exists. Practical implications If the steps proposed and illustrated in the paper were followed, it is possible that quality projects could avoid waste by ensuring the conditions they need for success are in place, and sustain and spread improvement changes more effectively. Social implications More patients could benefit more quickly from more effective implementation of proven interventions. Originality/value The paper is the first to describe how improvement and implementation science can be combined in a tangible way that practical improvers can use in their projects. It shows how QI project teams can take advantage of recent advances in improvement and implementation science to make their work more effective and sustainable.

  10. Solar shading for low energy use and daylight quality in offices: Simulations, measurements and design tools

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, M.C.

    2001-11-01

    This thesis investigates the impact of solar shading devices on energy use and daylight quality in office rooms. The impact on energy use is analysed through computer simulations with the dynamic energy simulation program Derob-LTH while the impact on daylight quality is investigated through measurements in full-scale experimental office rooms and simulations with the program Radiance. This thesis also includes a literature review of research on solar shading as well as design tools to incorporate shading devices at an early stage in the design of buildings. This thesis indicates that, in cold countries, shading devices may provide more annual energy savings than any solar-protective (reflective, tinted) glazing and that the optimum glazing transmittance is orientation- and climate-dependent. For example, high annual energy savings are obtained on the south facade with higher transmittance glazings (compared with the east and west facade) because the potential for passive solar gain utilisation in the winter is high in comparison with the annual cooling demand. Exterior shading devices like awnings and overhangs may reduce the cooling demand dramatically but they are not suitable as daylight (glare) control devices. Devices like screens and venetian blinds are preferable because they cover the entire window area, which prevents sunlight patches in the room and the direct view of the bright sky. Screens and venetian blinds also reduce daylight in the room to levels that are suitable for computer work. However, it is essential that the screen is of a diffusing type since screens with a strong (specular) transmittance component result in poor daylight quality. The study on daylight quality also indicated that a screen transmittance of around 15 % may be optimum for a standard (3.5 by 6.0 m{sup 2}) south-oriented office room with a window covering around 25 % of the facade area (12 % of the floor area)

  11. 78 FR 22501 - Designation of Areas for Air Quality Planning Purposes; State of Nevada; Total Suspended Particulate

    Science.gov (United States)

    2013-04-16

    ... Areas for Air Quality Planning Purposes; State of Nevada; Total Suspended Particulate AGENCY... designations for total suspended particulate within the State of Nevada because the designations are no longer necessary. These designations relate to the attainment or unclassifiable areas for total suspended...

  12. CADDS [Computer-aided Drafting and Design System] brings quality and precision to the Canadian Maple [research reactor

    International Nuclear Information System (INIS)

    Goland, D.

    1989-01-01

    Atomic Energy of Canada Ltd (AECL) has found that using the ''intelligent'' Computer-Aided Drafting and Design System (CADDS) helped address design problems at an early stage and led to productivity gains of around 50 per cent. Other bonuses were the quality and precision of the designs and documents produced. Its application to the MAPLE research reactor project is described. (author)

  13. Application of Devices and Systems Designed for Power Quality Monitoring and Assessment

    Directory of Open Access Journals (Sweden)

    Wiesław Gil

    2014-03-01

    Full Text Available The paper presents the problems associated with increasing demands on the equipment and systems for power quality assessment (PQ, installed at power substations. Difficulties are signaled due to current lack of standards defining the test methodology of measuring devices. The necessary device properties and the structure of a large system operated in real time and designed to assess the PQ are discussed. The usefulness of multi-channel analyzers featuring the identification and registration of transients is pointed out. The desirability of synchrophasor assessment implementation and device integration by standard PN-EN 61850 with other SAS devices is also justified.

  14. EXPERIMENTAL RESEARCH OF DYNAMIC QUALITIES OF FREIGHT CARS WITH BOGIES OF DIFFERENT DESIGNS

    Directory of Open Access Journals (Sweden)

    S. V. Myamlin

    2014-04-01

    Full Text Available Purpose. With the advent of new designs of freright cars the task of designing the more modern bogies, assessment of their dynamic properties depending on the type and structure of pecularities, accounting the axle loadings, providing the dynamic and running characteristics, meeting the conditions of impact on the track, stability, and frame forces intensity etc. becomes especially important. In order to launch the new production into manufacture and to assess the dynamic properties using different designs of bogies the running testes were conducted. They allowed one to compare the dynamic performance of the new bogie with the existing models. Methodology. The study was conducted using the method of numerical integration and mathematical modeling of dynamic loading of freight cars using the software package «Dynamics of Rail Vehicles» («DYNRAIL». Findings. The results of studies of dynamic characteristics of open cars with new and worn wheels of bogie models 18-9771, 18-9770 and 18-578 in graphical and tabular form are presented. All figures are within the normative values and do not exceed the maximum admissible ones. Originality. When designing the bogie for loading 23.5 t/axle almost all available technical solutions to improve the characteristics of the freight car bogies (elastic bearers, cassette bearing in axle boxes, axle boxe adapter of original design, bilinear central spring suspension, etc. were used. Practical value. As a result of the engineering works on projecting and manufacturing of the improved designs of freight car bogies a new design was received. It is highly competitive with the dynamic qualities of the best ones. Made choice of rational values of elastic-dissipative parameters of the bogie allows one to create standard series of running gears for freight cars for promising operating conditions.The results are of practical importance. They have found reflection in the number of author’spublications in special and

  15. Application of the QFD as a design approach to ensure comfort in using hand tools : Can the design team complete the House of Quality appropriately?

    NARCIS (Netherlands)

    Kuijt-Evers, L.F.M.; Morel, K.P.N.; Eikelenberg, N.L.W.; Vink, P.

    2009-01-01

    Quality Function Deployment is proposed as an effective design method to integrate ergonomics needs and comfort into hand tool design because it explicitly addresses the translation of customer needs into engineering characteristics. A crucial step during QFD concerns the linking of engineering

  16. Predicted accommodative response from image quality in young eyes fitted with different dual-focus designs.

    Science.gov (United States)

    Faria-Ribeiro, Miguel; Amorim-de-Sousa, Ana; González-Méijome, José M

    2018-05-01

    To investigate the separated and combined influences of inner zone (IZ) diameter and effective add power of dual-focus contact lenses (CL) in the image quality at distance and near viewing, in a functional accommodating model eye. Computational wave-optics methods were used to define zonal bifocal pupil functions, representing the optic zones of nine dual-focus centre-distance CLs. The dual-focus pupil functions were defined having IZ diameters of 2.10 mm, 3.36 mm and 4.00 mm, with add powers of 1.5 D, 2.0 D and 2.5 D (dioptres), for each design, that resulted in a ratio of 64%/36% between the distance and treatment zone areas, bounded by a 6 mm entrance pupil. A through-focus routine was implemented in MATLAB to simulate the changes in image quality, calculated from the Visual Strehl ratio, as the eye with the dual-focus accommodates, from 0 to -3.00 D target vergences. Accommodative responses were defined as the changes in the defocus coefficient, combined with a change in fourth and sixth order spherical aberration, which produced a peak in image quality at each target vergence. Distance viewing image quality was marginally affected by IZ diameter but not by add power. Near image quality obtained when focussing the image formed by the near optics was only higher by a small amount compared to the other two IZ diameters. The mean ± standard deviation values obtained with the three adds were 0.28 ± 0.02, 0.23 ± 0.02 and 0.22 ± 0.02, for the small, medium and larger IZ diameters, respectively. On the other hand, near image quality predicted by focussing the image formed by the distance optics was considerably lower relatively to the other two IZ diameters. The mean ± standard deviation values obtained with the three adds were 0.15 ± 0.01, 0.38 ± 0.00 and 0.54 ± 0.01, for the small, medium and larger IZ diameters, respectively. During near viewing through dual-focus CLs, image quality depends on the diameter of the most inner zone of the CL, while add power

  17. Informational Reinforcement of Students’ Course Design Aimed at Promoting Engineers Training Quality in Technical Education

    Directory of Open Access Journals (Sweden)

    B. N. Guzanov

    2012-01-01

    Full Text Available Using the modern information technologies in educational process is regarded as one of the main directions in training the qualified specialists with systematic engineering thinking. The optimum combination of various educational technologies and computerized resources can improve teaching quality and promote students’ professional level. Taking as an example one of the basic technical disciplines of the engineering training curriculum at a technical higher school, the authors describe the computerized technology facilitating the course design. The technology in question - the «Reduktor» courseware - adapts the complex product of Autodesk –AutoCAD for educational purposes. The above program is the enhanced interface of AutoCAD, linked to the Microsoft Excel spreadsheet and the reference data library used for designing the reduction gear. The experimental research, based on the qualimetric approach and continuous diagnostic and prognostic monitoring of the key indices of knowledge acquisition, proves the effectiveness of informational reinforcement of students self-dependent work. 

  18. Designing for movement quality in exergames: lessons learned from observing senior citizens playing stepping games.

    Science.gov (United States)

    Skjæret, Nina; Nawaz, Ather; Ystmark, Kristine; Dahl, Yngve; Helbostad, Jorunn L; Svanæs, Dag; Vereijken, Beatrix

    2015-01-01

    Exergames are increasingly used as an exercise intervention to reduce fall risk in elderly. However, few exergames have been designed specifically for elderly, and we lack knowledge about the characteristics of the movements elicited by exergames and thereby about their potential to train functions important for fall risk reduction. This study investigates game elements and older players' movement characteristics during stepping exergames in order to inform exergame design for movement quality in the context of fall preventive exercise. Fourteen senior citizens (mean age 73 years ± 5.7, range 65 - 85) played 3 stepping exergames in a laboratory. Each of the exergames was described with respect to 7 game elements (physical space, sensing hardware technology, game graphics and sound, model of user, avatar/mapping of movements, game mechanism and game narrative). Five movement characteristics (weight shift; variation in step length, speed, and movement direction; visual independency) were scored on a 5-point Likert scale based on video observations of each player and each game. Disagreement between raters was resolved by agreement. Differences in scores for the 3 exergames were analyzed with a multivariate one-way ANOVA. The Mole received the highest sum score and the best score on each of the 5 movement characteristics (all p values independency (p < 0.03 and p < 0.0005, respectively), and lower than The Mole on speed variation (p < 0.05). The physical space players used when exergaming and the on-screen representation of the player, affected movement quality positively as indexed by multiple weight shifts and variation in stepping size, direction, and speed. Furthermore, players' movements improved when playing speed-affected game progression and when the game narrative was related to a natural context. Comparing differences in game elements with associated differences in game movement requirements provides valuable insights about how to design for movement quality

  19. Eco-design of low energy mechanical milling through implementation of quality function deployment and design for sustainability

    Science.gov (United States)

    Rashid, Muhammad Hanif Abd; Nor, Nik Hisyamudin Muhd; Selamat, Siti Norhana; Hassan, Mohd Fahrul; Rahim, Abd Khalil Abd; Ahmad, Mohd Fauzi; Ismail, Al Emran; Omar, Badrul; Mokhtar, Mohd Faiz; Turan, Faiz Mohd; Yokoyama, Seiji

    2017-04-01

    Malaysia as a developing country favor energy demand by years which created mainly from fossil fuel. Unfortunately, the action leads to significant increment in carbon dioxide (CO2) emission that causing the global warming. The most promising mitigation strategy is by deploying Carbon Capture and Storage (CCS) technology where mineral carbonation was identified as the safest method for permanent storage and does not require continuous monitoring. Accordingly, National Green Technology was launched in 2009 to support the growth of green technology development in Malaysia as a carbon mitigation strategy. Thus, this paper aims to propose the development of a conceptual eco-design for Low Energy Mechanical Milling (LEMM). The concept was proposed by using the Quality Function Deployment (QFD) tool with combination of sustainability determinants (DFS) namely economic, environmental and social which evaluated using Solidworks 2015 sustainability assessment. The results show the new product targets for LEMM in prior on energy consumption (MJ), selling price (MYR), material cost (MYR), carbon footprint (kg CO2) with weightage of 5.2, 4.2, 3.6 and 3.6 respectively. The implementation of DFS criteria into the QFD promote to reduce material used by 16%, 35% reduction of carbon footprint, 28% less energy consumption, 28% lower air acidification, 77% of water eutrophication declined and increased recyclability by 15%.

  20. Mobile Tourism Guide in the Context of Thai National Parks: The Effects of Mobile Design Qualities in TAM2

    Directory of Open Access Journals (Sweden)

    Trakulmaykee Numtip

    2014-01-01

    Full Text Available This study aims to predict the level of international tourists’ intention to use MTG in the context of Thai national parks, and investigates the roles of mobile design qualities (content quality, appearance quality, and interaction quality through perceived usefulness and perceived ease-of-use on intention. The mixed-method via exploratory sequential design is conducted this study. The qualitative approach is started in the first stage then quantitative approach is employed to analyze the large sample size. This study extends the TAM2 with mobile design qualities. The results shows the high level of international tourist’ intention to use MTG. It indicates that the international tourists will intent to the mobile tourism guide (MTG, if the MTG is provided for them. The direct factors of tourists’ intention are perceived usefulness, perceived ease-of-use, mobile content quality and mobile appearance quality. The most direct effect is mobile content quality. The qualities of content and appearance have the positive roles on perceived usefulness, while the qualities of appearance and interaction have the indirect effects through perceived ease-of-use on tourists’ intention. The proposed model provides the body of knowledge in the context of MTG, especially the factors of international tourists’ intention to use MTG.

  1. Modelling of the meridian flow in nominal and partial flow in axial and helico-centrifugal turbomachinery; Modelisation en regime nominal et partiel de l'ecoulement meridien dans les turbomachines axiales et helicocentrifuges

    Energy Technology Data Exchange (ETDEWEB)

    Ercolino, J.

    2001-01-15

    In this study, a fast analysis code for the meridian flow inside turbo-machineries has been developed. This code is based on the resolution of the averaged dynamical equations controlling the internal stationary and non-viscous flow in the relative reference frame. A linear combination of momentum equations has been used in the axial and radial directions to avoid the source term of the equations to become singular. The model developed is particularly adapted to the general case of compression machines, i.e.the mixed machines. Starting with the hypothesis of a finite number of blading and assuming an axisymmetric flow, the equations allowing to calculate the blading forces and the simplified kinematics of blade-to-blade flow have been developed. This kinematics takes into consideration the geometrical data supplied by manufacturers or by global design softwares. This last approach ensures a very efficient link in the framework of turbomachine design projects where the blades geometry is introduced in a very simple way for a first optimization approach. The results obtained seem to be very consistent in nominal flow but also in partial flow conditions as shown by the qualitative comparisons with test results. (J.S.)

  2. The Design of Mechatronics Simulator for Improving the Quality of Student Learning Course in Mechatronics

    Science.gov (United States)

    Kustija, J.; Hasbullah; Somantri, Y.

    2018-02-01

    Learning course on mechatronics specifically the Department of Electrical Engineering Education FPTK UPI still using simulation-aided instructional materials and software. It is still not maximizing students’ competencies in mechatronics courses required to skilfully manipulate the real will are implemented both in industry and in educational institutions. The purpose of this study is to submit a design of mechatronic simulator to improve student learning outcomes at the course mechatronics viewed aspects of cognitive and psychomotor. Learning innovation products resulting from this study is expected to be a reference and a key pillar for all academic units at UPI in implementing the learning environment. The method used in this research is quantitative method with the approach of Research and Development (R and D). Steps being taken in this study includes a preliminary study, design and testing of the design of mechatronic simulator that will be used in the course of mechatronics in DPTE FPTK UPI. Results of mechatronic design simulator which has been in testing using simulation modules and is expected to motivate students to improve the quality of learning good study results in the course of mechatronic expected to be realized.

  3. Design of a Clean Room for Quality Control of an Environmental Sampling in KINAC

    International Nuclear Information System (INIS)

    Yoon, Jongho; Ahn, Gil Hoon; Seo, Hana; Han, Kitek; Park, Il Jin

    2014-01-01

    The objective of environmental sampling and analysis for safeguards is to characterize the nuclear materials handled and the activities conducted at the specific locations. The KINAC is responsible for the conclusions drawn from the analytical results provided by the analytical laboratories. To assure the KINAC of the continuity of the quality of the analytical results provided by the laboratories, the KINAC will implement a quality control(QC) programme. One of the QC programme is to prepare QC samples. The establishment of a clean room is needed to handle QC samples due to stringent control of contamination. The KINAC designed a clean facility with cleanliness of ISO Class 6, the Clean Room for Estimation and Assay of trace Nuclear materials(CREAN) to meet conflicting requirements of a clean room and for handling of nuclear materials according to Korean laws. The clean room will be expected to acquire of a radiation safety license under these conditions in this year and continue to improve it. The construction of the CREAN facility will be completed by the middle of 2015. In terms of QC programme, the establishment of a clean room is essential and will be not only very helpful for setting of quality control system for the national environmental sampling programme but also be applied for the environmental sample analysis techniques to the nuclear forensics

  4. Subway platform air quality: Assessing the influences of tunnel ventilation, train piston effect and station design

    Science.gov (United States)

    Moreno, T.; Pérez, N.; Reche, C.; Martins, V.; de Miguel, E.; Capdevila, M.; Centelles, S.; Minguillón, M. C.; Amato, F.; Alastuey, A.; Querol, X.; Gibbons, W.

    2014-08-01

    A high resolution air quality monitoring campaign (PM, CO2 and CO) was conducted on differently designed station platforms in the Barcelona subway system under: (a) normal forced tunnel ventilation, and (b) with daytime tunnel ventilation systems shut down. PM concentrations are highly variable (6-128 μgPM1 m-3, 16-314 μgPM3 m-3, and 33-332 μgPM10 m-3, 15-min averages) depending on ventilation conditions and station design. Narrow platforms served by single-track tunnels are heavily dependent on forced tunnel ventilation and cannot rely on the train piston effect alone to reduce platform PM concentrations. In contrast PM levels in stations with spacious double-track tunnels are not greatly affected when tunnel ventilation is switched off, offering the possibility of significant energy savings without damaging air quality. Sampling at different positions along the platform reveals considerable lateral variation, with the greatest accumulation of particulates occurring at one end of the platform. Passenger accesses can dilute PM concentrations by introducing cleaner outside air, although lateral down-platform accesses are less effective than those positioned at the train entry point. CO concentrations on the platform are very low (≤1 ppm) and probably controlled by ingress of traffic-contaminated street-level air. CO2 averages range from 371 to 569 ppm, changing during the build-up and exchange of passengers with each passing train.

  5. [Research advances in secondary development of Chinese patent medicines based on quality by design concept].

    Science.gov (United States)

    Gong, Xing-Chu; Chen, Teng; Qu, Hai-Bin

    2017-03-01

    Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy. In this work, recent research advances in QbD concept implementation methods in the secondary development of Chinese patent medicines were reviewed, and five promising fields of the implementation of QbD concept were pointed out, including the research and development of TCM new drugs and Chinese medicine granules for formulation, modeling of pharmaceutical processes, development of control strategy based on industrial big data, strengthening the research of process amplification rules, and the development of new pharmaceutical equipment.. Copyright© by the Chinese Pharmaceutical Association.

  6. Designing a two-rank acceptance sampling plan for quality inspection of geospatial data products

    Science.gov (United States)

    Tong, Xiaohua; Wang, Zhenhua; Xie, Huan; Liang, Dan; Jiang, Zuoqin; Li, Jinchao; Li, Jun

    2011-10-01

    To address the disadvantages of classical sampling plans designed for traditional industrial products, we originally propose a two-rank acceptance sampling plan (TRASP) for the inspection of geospatial data outputs based on the acceptance quality level (AQL). The first rank sampling plan is to inspect the lot consisting of map sheets, and the second is to inspect the lot consisting of features in an individual map sheet. The TRASP design is formulated as an optimization problem with respect to sample size and acceptance number, which covers two lot size cases. The first case is for a small lot size with nonconformities being modeled by a hypergeometric distribution function, and the second is for a larger lot size with nonconformities being modeled by a Poisson distribution function. The proposed TRASP is illustrated through two empirical case studies. Our analysis demonstrates that: (1) the proposed TRASP provides a general approach for quality inspection of geospatial data outputs consisting of non-uniform items and (2) the proposed acceptance sampling plan based on TRASP performs better than other classical sampling plans. It overcomes the drawbacks of percent sampling, i.e., "strictness for large lot size, toleration for small lot size," and those of a national standard used specifically for industrial outputs, i.e., "lots with different sizes corresponding to the same sampling plan."

  7. Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody.

    Directory of Open Access Journals (Sweden)

    Fatemeh Torkashvand

    Full Text Available Cell culture feeds optimization is a critical step in process development of pharmaceutical recombinant protein production. Amino acids are the basic supplements of mammalian cell culture feeds with known effect on their growth promotion and productivity. In this study, we reported the implementation of the Plackett-Burman (PB multifactorial design to screen the effects of amino acids on the growth promotion and productivity of a Chinese hamster ovary DG-44 (CHO-DG44 cell line producing bevacizumab. After this screening, the amino acid combinations were optimized by the response surface methodology (RSM to determine the most effective concentration in feeds. Through this strategy, the final monoclonal antibody (mAb titre was enhanced by 70%, compared to the control group. For this particular cell line, aspartic acid, glutamic acid, arginine and glycine had the highest positive effects on the final mAb titre. Simultaneously, the impact of the designed amino acid feed on some critical quality attributes of bevacizumab was examined in the group with highest productivity. The product was analysed for N-glycan profiles, charge variant distribution, and low molecular weight forms. The results showed that the target product quality has been improved using this feeding strategy. It was shown how this strategy could significantly diminish the time and number of experiments in identifying the most effective amino acids and related concentrations in target product enhancement. This model could be successfully applied to other components of culture media and feeds.

  8. Quality

    International Nuclear Information System (INIS)

    Burnett, N.; Jeffries, J.; Mach, J.; Robson, M.; Pajot, D.; Harrigan, J.; Lebsack, T.; Mullen, D.; Rat, F.; Theys, P.

    1993-01-01

    What is quality? How do you achieve it? How do you keep it once you have got it. The answer for industry at large is the three-step hierarchy of quality control, quality assurance and Total quality Management. An overview is given of the history of quality movement, illustrated with examples from Schlumberger operations, as well as the oil industry's approach to quality. An introduction of the Schlumberger's quality-associated ClientLink program is presented. 15 figs., 4 ills., 16 refs

  9. Tailoring groundwater quality monitoring to vulnerability: a GIS procedure for network design.

    Science.gov (United States)

    Preziosi, E; Petrangeli, A B; Giuliano, G

    2013-05-01

    Monitoring networks aiming to assess the state of groundwater quality and detect or predict changes could increase in efficiency when fitted to vulnerability and pollution risk assessment. The main purpose of this paper is to describe a methodology aiming at integrating aquifers vulnerability and actual levels of groundwater pollution in the monitoring network design. In this study carried out in a pilot area in central Italy, several factors such as hydrogeological setting, groundwater vulnerability, and natural and anthropogenic contamination levels were analyzed and used in designing a network tailored to the monitoring objectives, namely, surveying the evolution of groundwater quality relating to natural conditions as well as to polluting processes active in the area. Due to the absence of an aquifer vulnerability map for the whole area, a proxi evaluation of it was performed through a geographic information system (GIS) methodology, leading to the so called "susceptibility to groundwater quality degradation". The latter was used as a basis for the network density assessment, while water points were ranked by several factors including discharge, actual contamination levels, maintenance conditions, and accessibility for periodical sampling in order to select the most appropriate to the network. Two different GIS procedures were implemented which combine vulnerability conditions and water points suitability, producing two slightly different networks of 50 monitoring points selected out of the 121 candidate wells and springs. The results are compared with a "manual" selection of the points. The applied GIS procedures resulted capable to select the requested number of water points from the initial set, evaluating the most confident ones and an appropriate density. Moreover, it is worth underlining that the second procedure (point distance analysis [PDA]) is technically faster and simpler to be performed than the first one (GRID + PDA).

  10. Conceptual designs for waste quality checking facilities for low level and intermediate level radioactive wastes and hazardous waste

    International Nuclear Information System (INIS)

    Driver, S.; Griffiths, M.; Leonard, C.D.; Smith, D.L.G.

    1992-01-01

    This report summarises work carried out on the design of facilities for the quality checking of Intermediate and Low Level Radioactive Waste and Hazardous Waste. The procedures used for the quality checking of these categories of waste are summarised. Three building options are considered: a separate LLW facility, a combined facility for LLW and HW and a Waste Quality Checking Facility for the three categories of waste. Budget Cost Estimates for the three facilities are given based on 1991 prices. (author)

  11. Application of quality assurance to the design, procurement and construction of the fast flux test facility

    International Nuclear Information System (INIS)

    Garland, D.L.; Glasscock, R.B.

    1978-01-01

    Experience has clearly demonstrated the need for effective quality assurance programmes throughout the design, procurement and construction phases of the Fast Flux Test Facility (FFTF). Formal quality assurance programmes for FFTF have contributed significantly to the achievement of project objectives thus far in a safe, reliable and predictable manner. Quality assurance programmes empolyed by major FFTF Project participants are based on the requirements of RDT Standard F 2-2, one of the first and most comprehensive standards of its kind. RDT F 2-2 is similar in its basic requirements to ANSI N45.2 and other quality assurance programme standards but differs in its degree of specificity, particularly in its coverage of development activities. RDT F 2-2 is widely applied to a variety of large and small nuclear energy development projects and technology programmes. Full implementation of RDT F 2-2 across the FFTF Project has had its problems and rewards. Problems have been encountered involving misinterpretation or overapplication of requirements. In some instances the problems pointed to the need for more specific requirements, and so the standard was amended to rectify the shortcomings. One valuable lesson learned is that feedback of use experience is essential to the development of a living, viable standard which can be beneficially applied to other projects. Benefits and cost savings have accrued from the preventive aspects of RDT F 2-2. Some examples of experiences and resulting amendments to RDT F 2-2, and their favourable impact on facility costs and schedule, are discussed in this paper. (author)

  12. Design and methods of the Midwest Stream Quality Assessment (MSQA), 2013

    Science.gov (United States)

    Garrett, Jessica D.; Frey, Jeffrey W.; Van Metre, Peter C.; Journey, Celeste A.; Nakagaki, Naomi; Button, Daniel T.; Nowell, Lisa H.

    2017-10-18

    During 2013, the U.S. Geological Survey (USGS) National Water-Quality Assessment Project (NAWQA), in collaboration with the USGS Columbia Environmental Research Center, the U.S. Environmental Protection Agency (EPA) National Rivers and Streams Assessment (NRSA), and the EPA Office of Pesticide Programs assessed stream quality across the Midwestern United States. This Midwest Stream Quality Assessment (MSQA) simultaneously characterized watershed and stream-reach water-quality stressors along with instream biological conditions, to better understand regional stressor-effects relations. The MSQA design focused on effects from the widespread agriculture in the region and urban development because of their importance as ecological stressors of particular concern to Midwest region resource managers.A combined random stratified selection and a targeted selection based on land-use data were used to identify and select sites representing gradients in agricultural intensity across the region. During a 14-week period from May through August 2013, 100 sites were selected and sampled 12 times for contaminants, nutrients, and sediment. This 14-week water-quality “index” period culminated with an ecological survey of habitat, periphyton, benthic macroinvertebrates, and fish at all sites. Sediment was collected during the ecological survey for analysis of sediment chemistry and toxicity testing. Of the 100 sites, 50 were selected for the MSQA random stratified group from 154 NRSA sites planned for the region, and the other 50 MSQA sites were selected as targeted sites to more evenly cover agricultural and urban stressor gradients in the study area. Of the 50 targeted sites, 12 were in urbanized watersheds and 21 represented “good” biological conditions or “least disturbed” conditions. The remaining 17 targeted sites were selected to improve coverage of the agricultural intensity gradient or because of historical data collection to provide temporal context for the

  13. The Quality of MOOCs: How to improve the design of open education and online courses for learners?

    NARCIS (Netherlands)

    Stracke, Christian M.

    2017-01-01

    This paper presents the current status of Open Education and MOOCs and discusses their quality following the main question: How can we introduce new design and evaluation methods and personalization strategies to improve the learning quality of Open Education? First, the dimensions of Open Education

  14. Improving the Quality of Online Discussion: The Effects of Strategies Designed Based on Cognitive Load Theory Principles

    Science.gov (United States)

    Darabi, Aubteen; Jin, Li

    2013-01-01

    This article focuses on heavy cognitive load as the reason for the lack of quality associated with conventional online discussion. Using the principles of cognitive load theory, four online discussion strategies were designed specifically aiming at reducing the discussants' cognitive load and thus enhancing the quality of their online discussion.…

  15. HIGH QUALITY ENVIRONMENTAL PRINCIPLES APPLIED TO THE ARCHITECTONIC DESIGN SELECTION PROCEDURE: THE NUTRE LAB CASE

    Directory of Open Access Journals (Sweden)

    Claudia Barroso Krause

    2012-06-01

    Full Text Available The need to produce more sustainable buildings has been influencing the design decisions all over the world. That’s why it is imperative, in Brazil, the development of strategies and method to aid the decision making during the design process, focused on high quality environmental. This paper presents a decision support tool based on the principles of sustainable construction developed by the Project, Architecture and Sustainability Research Group (GPAS of Federal University of Rio de Janeiro – Brazil. The methodology has been developed for the selection of a preliminary design of a laboratory to be built at Rio Technology Park at the University campus. The support provided by GPAS occurred in three stages: the elaboration of the Reference Guide for the competitors, the development of a methodology to evaluate the proposed solutions (based on environmental performance criteria and the assistance of the members of jury in the trial phase. The theoretical framework was based upon the concepts of the bioclimatic architecture, the procedures specified by the certification HQE® (Haute Qualité Environnementale and the method suggested by the ADDENDA® architecture office. The success of this experience points out the possibility to future application in similar cases.

  16. Capitalized design of smart medicine box for elderly person based on quality function deployment (QFD)

    Science.gov (United States)

    Lestari, Brina Cindy; Dewi, Dyah Santhi; Widodo, Rusminto Tjatur

    2017-11-01

    The elderly who has a particular disease need to take some medicines in everyday with correct dosages and appropriate by time schedules. However, the elderly frequently forget to take medicines because of their memory weakened. Consequently, the product innovation of elderly healthcare is required for helping elderly takes some medicine more easily. This research aims to develop a smart medicine box by applying quality function deployment method. The first step is identifying elderly requirements through an ethnographic approach by interviewing thirty-two of elderly people as respondents. Then, the second step is translated elderly requirements to technical parameter for designing a smart medicine box. The smart box design is focused on two main requirements which have highest importance rating including alarm reminder for taking medicine and automatic medicine box. Finally, the prototype design has been created and tested by using usability method. The result shown that 90% from ten respondents have positive respond on the feature of smart medicine box. The voice of alarm reminder smart medicine box is easy to understand by elderly people for taking medicines.

  17. Risk-based Process Development of Biosimilars as Part of the Quality by Design Paradigm.

    Science.gov (United States)

    Zalai, Dénes; Dietzsch, Christian; Herwig, Christoph

    2013-01-01

    In the last few years, several quality by design (QbD) studies demonstrated the benefit of systematic approaches for biopharmaceutical development. However, only very few studies identified biosimilars as a special case of product development. The targeted quality profile of biosimilars is strictly defined by the originator's product characteristic. Moreover, the major source of prior knowledge is the experience with the originator product itself. Processing this information in biosimilar development has a major effect on risk management and process development strategies. The main objective of this contribution is to demonstrate how risk management can facilitate the implementation of QbD in early-stage product development with special emphasis on fitting the reported approaches to biosimilars. Risk assessments were highlighted as important tools to integrate prior knowledge in biosimilar development. The risk assessment process as suggested by the International Conference on Harmonization (ICH Q9) was reviewed and three elements were identified to play a key role in targeted risk assessment approaches: proper understanding of target linkage, risk assessment tool compliance, and criticality threshold value. Adjusting these steps to biosimilar applications helped to address some unique challenges of these products such as a strictly defined quality profile or a lack of process knowledge. This contribution demonstrates the need for tailored risk management approaches for the risk-based development of biosimilars and provides novel tools for the integration of additional knowledge available for these products. The pharmaceutical industry is facing challenges such as profit loss and price competition. Companies are forced to rationalize business models and to cut costs in development as well as manufacturing. These trends recently hinder the implementation of any concepts that do not offer certain financial benefit or promise a long return of investment. Quality by

  18. The design, fabrication, and testing of WETF high-quality, long-term-storage, secondary containment vessels

    International Nuclear Information System (INIS)

    Fisher, Kane J.

    2000-01-01

    Los Alamos National Laboratory's Weapons Engineering Tritium Facility (WETF) requires secondary containment vessels to store primary tritium containment vessels. The primary containment vessel provides the first boundary for tritium containment. The primary containment vessel is stored within a secondary containment vessel that provides the secondary boundary for tritium containment. WETF requires high-quality, long-term-storage, secondary tritium containment vessels that fit within a Mound-designed calorimeter. In order to qualify the WETF high-quality, long-term-storage, secondary containment vessels for use at WETF, steps have been taken to ensure the appropriate design, adequate testing, quality in fabrication, and acceptable documentation

  19. Implementation of "Quality by Design (QbD)" Approach for the Development of 5-Fluorouracil Loaded Thermosensitive Hydrogel.

    Science.gov (United States)

    Dalwadi, Chintan; Patel, Gayatri

    2016-01-01

    The purpose of this study was to investigate Quality by Design (QbD) principle for the preparation of hydrogel products to prove both practicability and utility of executing QbD concept to hydrogel based controlled release systems. Product and process understanding will help in decreasing the variability of critical material and process parameters, which give quality product output and reduce the risk. This study includes the identification of the Quality Target Product Profiles (QTPPs) and Critical Quality Attributes (CQAs) from literature or preliminary studies. To identify and control the variability in process and material attributes, two tools of QbD was utilized, Quality Risk Management (QRM) and Experimental Design. Further, it helps to identify the effect of these attributes on CQAs. Potential risk factors were identified from fishbone diagram and screened by risk assessment and optimized by 3-level 2- factor experimental design with center points in triplicate, to analyze the precision of the target process. This optimized formulation was further characterized by gelling time, gelling temperature, rheological parameters, in-vitro biodegradation and in-vitro drug release. Design space was created using experimental design tool that gives the control space and working within this controlled space reduces all the failure modes below the risk level. In conclusion, QbD approach with QRM tool provides potent and effectual pyramid to enhance the quality into the hydrogel.

  20. Service Quality Robust Design by the Integration of Taguchi Experiments and SERVQUAL Approach in a Travel Agency

    Directory of Open Access Journals (Sweden)

    nassibeh janatyan

    2012-02-01

    Full Text Available The main purpose of this research is to address how robust design of service quality dimensions can be obtained. Service Quality Robust Design has been conducted by the integration of Taguchi Design of Experiments and SERVQUAL approach in Iran Travel Agency. Five basic dimensions of service quality, i.e. reliability, responsiveness, assurance, empathy, tangibles and price have been assumed as control factors. Response factor has been defined as two alternatives i the sum of customer expectations, and ii the sum of service quality gaps. In this investigation assumed that noise factor is not existed. The advantage of this paper is to improve the average and standard deviation simultaneously. Signal to noise ratio has been computed and the desired mix of the levels of service quality dimensions has been addressed. The main findings of this research includes the desired mix of the levels of service quality dimensions based on the sum of customer expectations and the desired mix of the levels of service quality dimensions based on the sum of service quality gaps. Comparing the two sets of findings helps the agency to analyze the cost of attracting new customers or retaining regular customers.

  1. 76 FR 6056 - Additional Air Quality Designations for the 2006 24-Hour Fine Particle National Ambient Air...

    Science.gov (United States)

    2011-02-03

    ... Planning Texas. Section, EPA Region 6, 1445 Ross Avenue, Dallas, TX 75202, (214) 665-7242. Monica Morales... monitored air quality data for 2006-2008 indicating a violation of the NAAQS (2006-2008 design value of 48... NAAQS, with a 2007-2009 design value of 40 [micro]g/m\\3\\. In October of 2009, EPA notified the Governor...

  2. Comparison of Epicyclic Gearing Design Methods by Means of Quality Criteria Evaluation

    Directory of Open Access Journals (Sweden)

    I. V. Leonov

    2015-01-01

    Full Text Available The performance of modern economy depends on the usage of different machines. Execution of the many tasks a society entrusts to the machinery requires a huge amount of the mechanical energy imparted to the mechanical system due to different engines. Combining the motors and actuators in turn occurs through various transmissions.Among the numerous types of transmission the planetary gears occupy an important place. With a number of advantages and differences from other types of transmission of rotational motion, planetary gear can be used as a gear or a differential gear. The planetary gear firmly holds a leading position for its frequent use in transmissions of various technological and transport vehicles, as it has a convenient layout and high load capacity.Despite the fact that people have been using planetary gears over two thousand years, there is no simple method of their design, allowing both a minimizing design time and an optimization of their performance characteristics and technological qualities.The proposed design method is derived from the classical method of factors. It limits the number of options by isolating a promising region of a set of reduced criteria values of the overall dimensions, one of the main design criteria. A minimizing size criterion optimization is provided through rapprochement of gear sizes in two rows of gearings and proximity to the minimum possible number of teeth from the undercut condition, environment for numerous satellites, and gear assembly as well as through specifying the numbers of teeth of one of the rows to be equal to the arithmetic average of the teeth numbers of the other row.

  3. Comparison of HTGR fuel design, manufacture and quality control methods between Japan and China

    International Nuclear Information System (INIS)

    Fu Xioming; Takahashi, Masashi; Ueta, Shouhei; Sawa, Kazuhiro

    2002-05-01

    The first-loading fuel for the HTTR was started to fabricate at Nuclear Fuel Industries (NFI) in 1995 and the HTTR reached criticality in 1998. Meanwhile, 10 MW high temperature reactor (HTR-10) was constructed in Institute of Nuclear Energy Technology (INET) of Tsinghua University, and the first-loading fuel was fabricated concurrently. The HTR-10 reached criticality in December 2000. Though fuel type is different, i.e., pin-in-block type for the HTTR and pebble bed type for the HTR-10, the fabrication method of TRISO coated fuel particles is similar to each other. This report describes comparison of fuel design, fabrication process and quality inspection between them. (author)

  4. Design of RF chopper system for improving beam quality in FEL injector with thermionic gun

    International Nuclear Information System (INIS)

    Chen, Q.; Qin, B.; Tan, P.; Hu, T.; Pei, Y.; Zhang, F.

    2014-01-01

    For a linac-based Free Electron Laser (FEL), good beam quality largely contributes to the success of the final radiation. An imperfection confronted with the HUST THz-FEL facility is the long beam tail that emerges in the electron gun and exists through the whole beam line. This paper proposes to deploy a chopper system after the electron gun to truncate the beam tails before they enter into the linac. Physical dimensions of the chopper cavity are discussed in detail and we have developed and derived new analytical expressions applying to all frequencies for the optimal design. Also, technical issues of the cavity are considered. Beam dynamic simulation is performed to examine the truncation effect and the results show that more than 78% of the beam tail can be removed effectively, while preserving the emittance and energy spread in acceptable level

  5. Design and simulation study of the immunization Data Quality Audit (DQA).

    Science.gov (United States)

    Woodard, Stacy; Archer, Linda; Zell, Elizabeth; Ronveaux, Olivier; Birmingham, Maureen

    2007-08-01

    The goal of the Data Quality Audit (DQA) is to assess whether the Global Alliance for Vaccines and Immunization-funded countries are adequately reporting the number of diphtheria-tetanus-pertussis immunizations given, on which the "shares" are awarded. Given that this sampling design is a modified two-stage cluster sample (modified because a stratified, rather than a simple, random sample of health facilities is obtained from the selected clusters); the formula for the calculation of the standard error for the estimate is unknown. An approximated standard error has been proposed, and the first goal of this simulation is to assess the accuracy of the standard error. Results from the simulations based on hypothetical populations were found not to be representative of the actual DQAs that were conducted. Additional simulations were then conducted on the actual DQA data to better access the precision of the DQ with both the original and the increased sample sizes.

  6. Design and Construction of a Test Phantom for Screen/Film Mammography Quality Control

    International Nuclear Information System (INIS)

    Galvan, Hector; Grabski, Varlen; Ruiz, Cesar; Brandan, Maria-Ester; Villasenor, Yolanda

    2006-01-01

    A 10 x 10 x 4 cm Lucite phantom for quality control tests in mammography has been designed and built. It contains internal elements to quantify contrast and resolution, a mixture of talc and Lucite fibers to simulate the breast architecture, a 9-step aluminum wedge to verify the constancy of the film developing process, and metallic foils to evaluate kVp. Associated with an ionization chamber, the mean glandular dose can be evaluated. Its performance has been compared against the phantom accredited by the American College of Radiology. For a series of kV, both phantoms OD are similar within 5%. The step wedge can detect developer temperature changes of ±1 deg. C. Relative metal foils/acrylic OD permits to calculate kVp with precision of ±0.43 kV. Radiological measurements have been interpreted by numerical calculations

  7. Data Model and Relational Database Design for Highway Runoff Water-Quality Metadata

    Science.gov (United States)

    Granato, Gregory E.; Tessler, Steven

    2001-01-01

    A National highway and urban runoff waterquality metadatabase was developed by the U.S. Geological Survey in cooperation with the Federal Highway Administration as part of the National Highway Runoff Water-Quality Data and Methodology Synthesis (NDAMS). The database was designed to catalog available literature and to document results of the synthesis in a format that would facilitate current and future research on highway and urban runoff. This report documents the design and implementation of the NDAMS relational database, which was designed to provide a catalog of available information and the results of an assessment of the available data. All the citations and the metadata collected during the review process are presented in a stratified metadatabase that contains citations for relevant publications, abstracts (or previa), and reportreview metadata for a sample of selected reports that document results of runoff quality investigations. The database is referred to as a metadatabase because it contains information about available data sets rather than a record of the original data. The database contains the metadata needed to evaluate and characterize how valid, current, complete, comparable, and technically defensible published and available information may be when evaluated for application to the different dataquality objectives as defined by decision makers. This database is a relational database, in that all information is ultimately linked to a given citation in the catalog of available reports. The main database file contains 86 tables consisting of 29 data tables, 11 association tables, and 46 domain tables. The data tables all link to a particular citation, and each data table is focused on one aspect of the information collected in the literature search and the evaluation of available information. This database is implemented in the Microsoft (MS) Access database software because it is widely used within and outside of government and is familiar to many

  8. Quality and innovation between tipical products exploiting and new food design

    Directory of Open Access Journals (Sweden)

    Marco Dalla Rosa

    2011-02-01

    Full Text Available Scientific approach is often ignored in the production of typical and marginal foods which come from empiric trial and procedures consolidated along the time. At the beginning of the twentieth century food science starter influencing food production and processing by a multidisciplinary approach aiming at the safety guarantee of industrial products intended for large scale consumption. In the last decades researchers started taking into account traditional and marginal food products by an accurate scientific approach aiming to their exploitation and to define their quality and safety parameters. Scientific approach to marginal products can be schematically divided in two levels: analytical and technological/engineering. In general, the analytical approach focuses on chemical aspects, physical properties, aromatic and sensorial characteristics and on the microbiological and genetic characterizations. 

    The technological/engineering approach must be considered a san integration of the knowledge both about the finished product and the production process and consists of: the definition of markers connecting quality to first matter; the study of seasonal and annual variability; the search for correlations among process/environment/quality on molecular basis; the pointing out of markers to set traceability systems up; the definition of key-factors to characterize the land according to its food production as an impulse for the development of other sectors such as tourism. Finally, innovation in the sector of traditional and marginal production should concern the definition of chemicalphysical and sensorial characteristics, the rationalization of traditional processes and the introduction of new compatible technology phases, the introduction of new packaging forms to elongate the shelf life and to enlarge distribution areas guaranteeing, at the same time, the maintenance of product peculiarity and typicality. New food design is one of the most

  9. Quality and innovation between tipical products exploiting and new food design

    Directory of Open Access Journals (Sweden)

    Dino Mastrocola

    2008-04-01

    Full Text Available Scientific approach is often ignored in the production of typical and marginal foods which come from empiric trial and procedures consolidated along the time. At the beginning of the twentieth century food science starter influencing food production and processing by a multidisciplinary approach aiming at the safety guarantee of industrial products intended for large scale consumption. In the last decades researchers started taking into account traditional and marginal food products by an accurate scientific approach aiming to their exploitation and to define their quality and safety parameters. Scientific approach to marginal products can be schematically divided in two levels: analytical and technological/engineering. In general, the analytical approach focuses on chemical aspects, physical properties, aromatic and sensorial characteristics and on the microbiological and genetic characterizations. The technological/engineering approach must be considered a san integration of the knowledge both about the finished product and the production process and consists of: the definition of markers connecting quality to first matter; the study of seasonal and annual variability; the search for correlations among process/environment/quality on molecular basis; the pointing out of markers to set traceability systems up; the definition of key-factors to characterize the land according to its food production as an impulse for the development of other sectors such as tourism. Finally, innovation in the sector of traditional and marginal production should concern the definition of chemicalphysical and sensorial characteristics, the rationalization of traditional processes and the introduction of new compatible technology phases, the introduction of new packaging forms to elongate the shelf life and to enlarge distribution areas guaranteeing, at the same time, the maintenance of product peculiarity and typicality. New food design is one of the most

  10. Regularization design for high-quality cone-beam CT of intracranial hemorrhage using statistical reconstruction

    Science.gov (United States)

    Dang, H.; Stayman, J. W.; Xu, J.; Sisniega, A.; Zbijewski, W.; Wang, X.; Foos, D. H.; Aygun, N.; Koliatsos, V. E.; Siewerdsen, J. H.

    2016-03-01

    Intracranial hemorrhage (ICH) is associated with pathologies such as hemorrhagic stroke and traumatic brain injury. Multi-detector CT is the current front-line imaging modality for detecting ICH (fresh blood contrast 40-80 HU, down to 1 mm). Flat-panel detector (FPD) cone-beam CT (CBCT) offers a potential alternative with a smaller scanner footprint, greater portability, and lower cost potentially well suited to deployment at the point of care outside standard diagnostic radiology and emergency room settings. Previous studies have suggested reliable detection of ICH down to 3 mm in CBCT using high-fidelity artifact correction and penalized weighted least-squared (PWLS) image reconstruction with a post-artifact-correction noise model. However, ICH reconstructed by traditional image regularization exhibits nonuniform spatial resolution and noise due to interaction between the statistical weights and regularization, which potentially degrades the detectability of ICH. In this work, we propose three regularization methods designed to overcome these challenges. The first two compute spatially varying certainty for uniform spatial resolution and noise, respectively. The third computes spatially varying regularization strength to achieve uniform "detectability," combining both spatial resolution and noise in a manner analogous to a delta-function detection task. Experiments were conducted on a CBCT test-bench, and image quality was evaluated for simulated ICH in different regions of an anthropomorphic head. The first two methods improved the uniformity in spatial resolution and noise compared to traditional regularization. The third exhibited the highest uniformity in detectability among all methods and best overall image quality. The proposed regularization provides a valuable means to achieve uniform image quality in CBCT of ICH and is being incorporated in a CBCT prototype for ICH imaging.

  11. Development and testing of a measure designed to assess the quality of care transitions

    Directory of Open Access Journals (Sweden)

    Eric A. Coleman

    2002-06-01

    Full Text Available Background: To improve the quality of care delivered to older persons receiving care across multiple settings, interventions are needed. However, the absence of a patient-centred measure specifically designed to assess this care has constrained innovation. Objective: To develop a rigorously designed and tested measure, the Care Transition Measure (CTM. Setting: A large, integrated managed care organisation in Colorado with approximately 55,000 members over the age of 65 years. Participants: Patients 65 years and older who were recently discharged from hospital and received subsequent skilled nursing care in a facility or in the home. Methods: Six focus groups of older persons and their caregivers (n=49 were established. Standard qualitative analytic techniques were applied to written transcripts and four key domains were identified: (1 information transfer; (2 patient and caregiver preparation; (3 self-management support; and (4 empowerment to assert preferences. Specific CTM items were developed, pilot tested, and refined. Psychometric testing, conducted in a different population but selected using the same entry criteria (n=60, included content and construct validity, intra-item variation, and floor/ceiling properties. Results: Older patients and clinicians found the measure to be highly relevant and comprehensive (i.e. content validity. Construct validity was assessed by comparing items from the CTM to selected items from a measure developed by Hendriks and colleagues (Medical Care 2001; 39(3: 270–283. Inter-item Spearman correlations ranged 0.388–0.594. No significant floor or ceiling effects were detected. Conclusions: The CTM was developed with substantial input from older patients and their caregivers. Psychometric testing suggested that the measure was valid. The CTM may serve to fill an important gap in health system performance evaluation by measuring the quality of care delivered across settings.

  12. Slim edge studies, design and quality control of planar ATLAS IBL pixel sensors

    Energy Technology Data Exchange (ETDEWEB)

    Wittig, Tobias

    2013-05-08

    One of the four large experiments at the LHC at CERN is the ATLAS detector, a multi purpose detector. Its pixel detector, composed of three layers, is the innermost part of the tracker. As it is closest to the interaction point, it represents a basic part of the track reconstruction. Besides the requested high resolution one main requirement is the radiation hardness. In the coming years the radiation damage will cause deteriorations of the detector performance. With the planned increase of the luminosity, especially after the upgrade to the High Luminosity LHC, this radiation damage will be even intensified. This circumstance necessitates a new pixel detector featuring improved radiation hard sensors and read-out chips. The present shutdown of the LHC is already utilized to insert an additional b-layer (IBL) into the existing ATLAS pixel detector. The current n-in-n pixel sensor design had to be adapted to the new read-out chip and the module specifications. The new stave geometry requests a reduction of the inactive sensor edge. In a prototype wafer production all modifications have been implemented. The sensor quality control was supervised which led to the decision of the final sensor thickness. In order to evaluate the performance of the sensor chip assemblies with an innovative slim edge design, they have been operated in test beam setups before and after irradiation. Furthermore, the quality control of the planar IBL sensor wafer production was supervised from the stage of wafer delivery to that before the flip chip process to ensure a sufficient amount of functional sensors for the module production.

  13. Design of high quality doped CeO2 solid electrolytes with nanohetero structure

    International Nuclear Information System (INIS)

    Mori, T.; Ou, D.R.; Ye, F.; Drennan, J.

    2006-01-01

    Doped cerium (CeO 2 ) compounds are fluorite related oxides which show oxide ionic conductivity higher than yttria-stabilized zirconia in oxidizing atmosphere. As a consequence of this, a considerable interest has been shown in application of these materials for low (400-650 o C) temperature operation of solid oxide fuel cells (SOFCs). In this paper, our experimental data about the influence of microstructure at the atomic level on electrochemical properties were reviewed in order to develop high quality doped CeO 2 electrolytes in fuel cell applications. Using this data in the present paper, our original idea for a design of nanodomain structure in doped CeO 2 electrolytes was suggested. The nanosized powders and dense sintered bodies of M doped CeO 2 (M:Sm,Gd,La,Y,Yb, and Dy) compounds were fabricated. Also nanostructural features in these specimens were introduced for conclusion of relationship between electrolytic properties and domain structure in doped CeO 2 . It is essential that the electrolytic properties in doped CeO 2 solid electrolytes reflect in changes of microstructure even down to the atomic scale. Accordingly, a combined approach of nanostructure fabrication, electrical measurement and structure characterization was required to develop superior quality doped CeO 2 electrolytes in the fuel cells. (author)

  14. Analysis of the HVAC system's sound quality using the design of experiments

    International Nuclear Information System (INIS)

    Park, Sang Gil; Sim, Hyun Jin; Yoon, Ji Hyun; Jeong, Jae Eun; Choi, Byoung Jae; Oh, Jae Eung

    2009-01-01

    Human hearing is very sensitive to sound, so a subjective index of sound quality is required. Each situation of sound evaluation is composed of Sound Quality (SQ) metrics. When substituting the level of one frequency band, we could not see the tendency of substitution at the whole frequency band during SQ evaluation. In this study, the Design of Experiments (DOE) is used to analyze noise from an automotive Heating, Ventilating, and Air Conditioning (HVAC) system. The frequency domain is divided into 12 equal parts, and each level of the domain is given an increase or decrease due to the change in frequency band based on the 'loud' and 'sharp' sound of the SQ analyzed. By using DOE, the number of tests is effectively reduced by the number of experiments, and the main result is a solution at each band. SQ in terms of the 'loud' and 'sharp' sound at each band, the change in band (increase or decrease in sound pressure) or no change in band will have the most effect on the identifiable characteristics of SQ. This will enable us to select the objective frequency band. Through the results obtained, the physical level changes in arbitrary frequency domain sensitivity can be determined

  15. Design of a practical model-observer-based image quality assessment method for CT imaging systems

    Science.gov (United States)

    Tseng, Hsin-Wu; Fan, Jiahua; Cao, Guangzhi; Kupinski, Matthew A.; Sainath, Paavana

    2014-03-01

    The channelized Hotelling observer (CHO) is a powerful method for quantitative image quality evaluations of CT systems and their image reconstruction algorithms. It has recently been used to validate the dose reduction capability of iterative image-reconstruction algorithms implemented on CT imaging systems. The use of the CHO for routine and frequent system evaluations is desirable both for quality assurance evaluations as well as further system optimizations. The use of channels substantially reduces the amount of data required to achieve accurate estimates of observer performance. However, the number of scans required is still large even with the use of channels. This work explores different data reduction schemes and designs a new approach that requires only a few CT scans of a phantom. For this work, the leave-one-out likelihood (LOOL) method developed by Hoffbeck and Landgrebe is studied as an efficient method of estimating the covariance matrices needed to compute CHO performance. Three different kinds of approaches are included in the study: a conventional CHO estimation technique with a large sample size, a conventional technique with fewer samples, and the new LOOL-based approach with fewer samples. The mean value and standard deviation of area under ROC curve (AUC) is estimated by shuffle method. Both simulation and real data results indicate that an 80% data reduction can be achieved without loss of accuracy. This data reduction makes the proposed approach a practical tool for routine CT system assessment.

  16. Design of Simple Instrumentation System for the Quality Analysis of Milk (Casein Analysis

    Directory of Open Access Journals (Sweden)

    V. G. Sangam

    2010-08-01

    Full Text Available This paper describes the design of a simple instrumentation system for the analysis of casein concentration in the milk. Casein is one of the major constituent of milk and its concentration describes the quality of the milk. Normally casein is analyzed by conventional analytical methods or by using Spectrophotometric methods. Here an attempt has been made to develop a simple portable system using optical instrumentation technique. The objective of the developed system is the real time analysis of the casein concentration of the milk at the field. The system involves UV light source, UV filter, cuvette, photo detector, display unit, data Acquisition Card (DAC as peripheral with USB port. Appropriate program has been developed in visual studio 6 and turbo C. Repeated number of real time analysis was carried out for different samples of milk; the results obtained are in excellent agreement with the amount determined by standard conventional methods with an accuracy of ±1.5 %, and the response time is within 100 seconds. This system can be used in the field for the quality analysis of milk as an independent unit and can also be interfaced to PC with USB port. The system has good accuracy, less response time and low cost.

  17. Mild separation system for olive oil: quality evaluation and pilot plant design

    Directory of Open Access Journals (Sweden)

    Francesco Genovese

    2013-09-01

    Full Text Available The entire process of olive oil extraction involves the breakage of olive fruits to obtain a paste, the kneading of the paste, a centrifugation, and a further cleaning, performed by a disc stack centrifuge, to separate the residual water. In this research, in order to evaluate the effect of final centrifugal separation on olive oil quality and to both define and design the settings of a innovative separation system, olive oil was separated off from water using an accelerated separation process, tested in comparison with a disc centrifuge. The laboratory plant used for the trials was constituted by a twin cylindrical separator equipped with 4 variable frequency inverters, in order to regulate the fluid flow rates in the plant. Oil samples were collected during the trials to evaluate the influence of the proposed innovative process on oil quality; measuring some parameters as free acidity, peroxides (PV, specific extinction coefficients K232 and K270, chlorophylls , carotenoids, total polyphenols (POL and turbidity. Results showed statistically significant differences (p-values<0.05 in some parameters as POL, PV, and ultraviolet absorption K232 and K270.

  18. Application of the QFD as a design approach to ensure comfort in using hand tools: can the design team complete the House of Quality appropriately?

    Science.gov (United States)

    Kuijt-Evers, L F M; Morel, K P N; Eikelenberg, N L W; Vink, P

    2009-05-01

    Quality Function Deployment is proposed as an effective design method to integrate ergonomics needs and comfort into hand tool design because it explicitly addresses the translation of customer needs into engineering characteristics. A crucial step during QFD concerns the linking of engineering characteristics to customer needs in the House of Quality by the design team. It is generally assumed (looking at all the QFD success stories) that design teams can accurately predict the correlations between customer needs and engineering characteristics (also referred to as "Whats"/"Hows" correlations). This paper explicitly tests this assumption by comparing the "Whats"/"Hows" correlations estimated by a design team with those observed in a systematic user evaluation study, which has not been done before. Testing the assumption is important, because inaccurate estimates may lead to ergonomically ineffective (re)design of hand tools and a waste of company resources. Results revealed that the design team's correlation estimates were not as accurate as is generally assumed. Twenty-five percent of the estimates differed significantly with those observed in the user evaluation study. Thus, QFD is a useful method to assist design teams in designing ergonomically more comfortable hand tools, but only on the condition that the correlations between customer needs and engineering characteristics are validated, preferably by means of a systematic user evaluation study.

  19. Analytical Quality by Design in pharmaceutical quality assurance: Development of a capillary electrophoresis method for the analysis of zolmitriptan and its impurities.

    Science.gov (United States)

    Orlandini, Serena; Pasquini, Benedetta; Caprini, Claudia; Del Bubba, Massimo; Pinzauti, Sergio; Furlanetto, Sandra

    2015-11-01

    A fast and selective CE method for the determination of zolmitriptan (ZOL) and its five potential impurities has been developed applying the analytical Quality by Design principles. Voltage, temperature, buffer concentration, and pH were investigated as critical process parameters that can influence the critical quality attributes, represented by critical resolution values between peak pairs, analysis time, and peak efficiency of ZOL-dimer. A symmetric screening matrix was employed for investigating the knowledge space, and a Box-Behnken design was used to evaluate the main, interaction, and quadratic effects of the critical process parameters on the critical quality attributes. Contour plots were drawn highlighting important interactions between buffer concentration and pH, and the gained information was merged into the sweet spot plots. Design space (DS) was established by the combined use of response surface methodology and Monte Carlo simulations, introducing a probability concept and thus allowing the quality of the analytical performances to be assured in a defined domain. The working conditions (with the interval defining the DS) were as follows: BGE, 138 mM (115-150 mM) phosphate buffer pH 2.74 (2.54-2.94); temperature, 25°C (24-25°C); voltage, 30 kV. A control strategy was planned based on method robustness and system suitability criteria. The main advantages of applying the Quality by Design concept consisted of a great increase of knowledge of the analytical system, obtained throughout multivariate techniques, and of the achievement of analytical assurance of quality, derived by probability-based definition of DS. The developed method was finally validated and applied to the analysis of ZOL tablets. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Effects of natural-channel-design restoration on habitat quality in Catskill Mountain streams, New York

    Science.gov (United States)

    Ernst, Anne G.; Baldigo, Barry P.; Mulvihill, Christiane; Vian, Mark

    2010-01-01

    Stream restoration has received much attention in recent years, yet there has been little effort to evaluate its impacts on physical habitat, stability, and biota. A popular but controversial stream restoration approach is natural channel design (NCD), which cannot be adequately evaluated without a long-term, independent assessment of its effects on stream habitat. Six reaches of five Catskill Mountain streams in southeastern New York were restored during 2000–2003 following NCD techniques to decrease bed and bank degradation, decrease sediment loads, and improve water quality. Habitat surveys were conducted during summer low flows from 2001 to 2007. The effects of the NCD projects on stream condition were assessed via a before–after–control–impact study design to quantify the net changes in stream and bank habitat variables relative to those in unaltered control reaches. Analysis of variance tests of three different measures of bank stability show that on average stream stability increased at treatment sites for 2–5 years after restoration. Mean channel depth, thalweg depth, and the pool–riffle ratio generally increased, whereas mean channel width, percent streambank coverage by trees, and shade decreased. Habitat suitability indices for local salmonid species increased at four of six reaches after restoration. The changes in channel dimensions rendered them generally more characteristic of stabler stream forms in the given valley settings. Although these studies were done relatively soon after project completion, our findings demonstrate that habitat conditions can be improved in degraded Catskill Mountain streams through NCD restoration.

  1. The Design of an Autonomous Underwater Vehicle for Water Quality Monitoring

    Science.gov (United States)

    Li, Yulong; Liu, Rong; Liu, Shujin

    2018-01-01

    This paper describes the development of a civilian-used autonomous underwater vehicle (AUV) for water quality monitoring at reservoirs and watercourses that can obtain realtime visual and locational information. The mechanical design was completed with CAD software Solidworks. Four thrusters—two horizontal and two vertical—on board enable the vehicle to surge, heave, yaw, and pitch. A specialized water sample collection compartment is designed to perform water collection at target locations. The vehicle has a central controller—STM32—and a sub-coordinate controller—Arduino MEGA 2560—that coordinates multiple sensors including an inertial sensor, ultrasonic sensors, etc. Global Navigation Satellite System (GNSS) and the inertial sensor enable the vehicle’s localization. Remote operators monitor and control the vehicle via a host computer system. Operators choose either semi-autonomous mode in which they set target locations or manual mode. The experimental results show that the vehicle is able to perform well in either mode.

  2. Architecture and Design of Expert System for Quality of Life Evaluation

    Directory of Open Access Journals (Sweden)

    Irena ATANASOVA

    2013-01-01

    Full Text Available This article presents an architectural framework of an expert system (ES in the social area domain and describes the design of the ES, using the shell Expert System for Text Animation (ESTA. The designed system is intended for the evaluation of quality of life (QL. The development of ES for QL evaluation is a new information technology derived from artificial intelligent research, using ESTA system with application in social area domain. The proposed ES contains knowledge about sets of factors (objective conditions and subjective perception and indicators, which may be used to QL measure, as followings: equal protection of the law; freedom from discrimination; right to be treated equally without regard to gender, race, language, religion, political beliefs, nationality, socio-economic status and more; right to privacy; freedom of thought; free choice of employment; right to fair pay; equal pay for equal work; right to vote; right to rest and leisure; right to education. The system is developed in the ESTA, which is Visual Prolog 7.3 Application. The knowledge for the ES will be acquired from domain experts, texts and other related sources.

  3. A Validation of Object-Oriented Design Metrics as Quality Indicators

    Science.gov (United States)

    Basili, Victor R.; Briand, Lionel C.; Melo, Walcelio

    1997-01-01

    This paper presents the results of a study in which we empirically investigated the suits of object-oriented (00) design metrics introduced in another work. More specifically, our goal is to assess these metrics as predictors of fault-prone classes and, therefore, determine whether they can be used as early quality indicators. This study is complementary to the work described where the same suite of metrics had been used to assess frequencies of maintenance changes to classes. To perform our validation accurately, we collected data on the development of eight medium-sized information management systems based on identical requirements. All eight projects were developed using a sequential life cycle model, a well-known 00 analysis/design method and the C++ programming language. Based on empirical and quantitative analysis, the advantages and drawbacks of these 00 metrics are discussed. Several of Chidamber and Kamerer's 00 metrics appear to be useful to predict class fault-proneness during the early phases of the life-cycle. Also, on our data set, they are better predictors than 'traditional' code metrics, which can only be collected at a later phase of the software development processes.

  4. Design, construction, and quality tests of the large Al-alloy mandrels for the CMS coil

    CERN Document Server

    Sgobba, Stefano; Fabbricatore, P; Farinon, S; Gaddi, A; Lauro, A; Levesy, B; Loche, L; Rondeaux, F; Sequeira-Lopes-Tavares, S; Valle, N

    2002-01-01

    The Compact Muon Solenoid (CMS) is one of the general-purpose detectors to be provided for the LHC project at CERN. The design field of the CMS superconducting magnet is 4 T, the magnetic length is 12.5 m and the free bore is 6 m. Almost all large indirectly cooled solenoids constructed to date (e.g., Zeus, Aleph, Delphi, Finuda, Babar) comprise Al-alloy mandrels fabricated by welding together plates bent to the correct radius. The external cylinder of CMS will consist of five modules having an inner diameter of 6.8 m, a thickness of 50 mm and an individual length of 2.5 m. It will be manufactured by bending and welding thick plates (75 mm) of the strain hardened aluminum alloy EN AW-5083-H321. The required high geometrical tolerances and mechanical strength (a yield strength of 209 MPa at 4.2 K) impose a critical appraisal of the design, the fabrication techniques, the welding procedures and the quality controls. The thick flanges at both ends of each module will be fabricated as seamless rolled rings, circu...

  5. Examining Design and Inter-Rater Reliability of a Rubric Measuring Research Quality across Multiple Disciplines

    Directory of Open Access Journals (Sweden)

    Marilee J. Bresciani

    2009-05-01

    Full Text Available The paper presents a rubric to help evaluate the quality of research projects. The rubric was applied in a competition across a variety of disciplines during a two-day research symposium at one institution in the southwest region of the United States of America. It was collaboratively designed by a faculty committee at the institution and was administered to 204 undergraduate, master, and doctoral oral presentations by approximately 167 different evaluators. No training or norming of the rubric was given to 147 of the evaluators prior to the competition. The findings of the inter-rater reliability analysis reveal substantial agreement among the judges, which contradicts literature describing the fact that formal norming must occur prior to seeing substantial levels of inter-rater reliability. By presenting the rubric along with the methodology used in its design and evaluation, it is hoped that others will find this to be a useful tool for evaluating documents and for teaching research methods.

  6. Institutional design and regime effectiveness in transboundary river management – the Elbe water quality regime

    Directory of Open Access Journals (Sweden)

    I. Dombrowsky

    2008-02-01

    Full Text Available The literature on transboundary river management suggests that institutions play an important role in bringing about cooperation. However, knowledge about how such institutions should be designed in order to do so remains limited. One way to learn more about adequate institutional design is to assess the effectiveness of existing regimes, and to trace the causal relationships that lead to the respective outcomes. In order to gain further insights into the relationship between institutional design and regime effectiveness, this paper presents a study on the water quality regime of the International Commission for the Protection of the Elbe (ICPE. The analysis is based on a review of pertinent documents and ten qualitative interviews with Czech and German Commission members and NGO representatives. Particular emphasis has been put on determining the ICPE's specific contribution and the no-regime counterfactual as well as on the perceived expediency of the institutional arrangements. The study shows overall that the countries were relatively successful in improving water quality in the Elbe basin. However, this outcome can only partly be attributed to the ICPE itself. Furthermore, the ICPE's contribution towards achieving the various goals varied significantly between the different areas of activity: it was relatively significant where the main responsibility for action lay with the public authorities, such as in the area of wastewater treatment and the establishment of an international alarm plan and model, but was practically non-existent in the reduction of non-point pollution from agriculture, where success depended on the behavior of individual private actors (farmers. The commission contributed towards problem solving by serving as a forum for the joint identification of priorities for action from a basin-wide perspective. The resulting international obligations increased the power of national water administrations and their access to funds

  7. Children's Health and Indoor Air Quality in Primary Schools and Homes in Portugal-Study Design.

    Science.gov (United States)

    Madureira, Joana; Paciência, Inês; Ramos, Elisabete; Barros, Henrique; Pereira, Cristiana; Teixeira, João Paulo; Fernandes, Eduardo de Oliveira

    2015-01-01

    The main aim of the research project "On the Contribution of Schools to Children's Overall Indoor Air Exposure" is to study associations between adverse health effects, namely, allergy, asthma, and respiratory symptoms, and indoor air pollutants to which children are exposed to in primary schools and homes. Specifically, this investigation reports on the design of the study and methods used for data collection within the research project and discusses factors that need to be considered when designing such a study. Further, preliminary findings concerning descriptors of selected characteristics in schools and homes, the study population, and clinical examination are presented. The research project was designed in two phases. In the first phase, 20 public primary schools were selected and a detailed inspection and indoor air quality (IAQ) measurements including volatile organic compounds (VOC), aldehydes, particulate matter (PM2.5, PM10), carbon dioxide (CO2), carbon monoxide (CO), bacteria, fungi, temperature, and relative humidity were conducted. A questionnaire survey of 1600 children of ages 8-9 years was undertaken and a lung function test, exhaled nitric oxide (eNO), and tear film stability testing were performed. The questionnaire focused on children's health and on the environment in their school and homes. One thousand and ninety-nine questionnaires were returned. In the second phase, a subsample of 68 children was enrolled for further studies, including a walk-through inspection and checklist and an extensive set of IAQ measurements in their homes. The acquired data are relevant to assess children's environmental exposures and health status.

  8. Performance of a generic non-axisymmetric end wall in a single stage, rotating turbine at on and off-design conditions

    CSIR Research Space (South Africa)

    Snedden, Glen C

    2010-06-01

    Full Text Available ) “Low Pressure Turbine Design for Rolls-Royce TRENT 900 Turbofan”, ASME Turbo Expo, GT2006-90997. [5] Denton J. D., (1993) “Loss Mechanisms in Turbomachines,” Transactions of the ASME Journal of Turbomachinery, Vol. 115, pp. 621-650. [6] Langston...

  9. [Designing and implementation of a web-based quality monitoring system for plasma glucose measurement in multicenter population study].

    Science.gov (United States)

    Liu, Yong; Wang, Limin; Pang, Richard; Mo, Nanxun; Hu, Yan; Deng, Qian; Hu, Zhaohui

    2015-05-01

    The aim of this paper is to describe the designing and implementation of a web-based plasma glucose measurement quality monitoring system to assess the analytical quality of plasma glucose measurements in multicenter population study and provide evidence for the future studies. In the chronic non-communicable disease and related factor surveillance in China, a web based quality monitoring system for plasma glucose measurement was established to conduct evaluation on plasma glucose monitoring quality and effectiveness in 302 surveillance centers, including quality control data entry, transmission and feedback. The majority of the surveillance centers met the quality requirements and passed the evaluation of reproducibility and precision of plasma glucose measurement, only a few centers required intensive training and re-assessment. In order to ensure the completeness and reliability of plasma glucose measurement in the surveillance centers, the establishment of web-based plasma glucose measurement quality control system can facilitate the identification of the qualified surveillance centers and evaluation of plasma glucose measurement quality in different regions. Communication and training are important in ensuring plasma glucose measurement quality. It is necessary to further improve this web-based plasma glucose measurement quality monitoring system in the future to reduce the method specific plasma glucose measurement bias.

  10. A Metric Tool for Predicting Source Code Quality from a PDL Design

    OpenAIRE

    Henry, Sallie M.; Selig, Calvin

    1987-01-01

    The software crisis has increased the demand for automated tools to assist software developers in the production of quality software. Quality metrics have given software developers a tool to measure software quality. These measurements, however, are available only after the software has been produced. Due to high cost, software managers are reluctant, to redesign and reimplement low quality software. Ideally, a life cycle which allows early measurement of software quality is a necessary ingre...

  11. A Machine Learning Regression scheme to design a FR-Image Quality Assessment Algorithm

    OpenAIRE

    Charrier , Christophe; Lezoray , Olivier; Lebrun , Gilles

    2012-01-01

    International audience; A crucial step in image compression is the evaluation of its performance, and more precisely available ways to measure the quality of compressed images. In this paper, a machine learning expert, providing a quality score is proposed. This quality measure is based on a learned classification process in order to respect that of human observers. The proposed method namely Machine Learning-based Image Quality Measurment (MLIQM) first classifies the quality using multi Supp...

  12. Assessing Assessment Quality: Criteria for Quality Assurance in Design of (Peer) Assessment for Learning--A Review of Research Studies

    Science.gov (United States)

    Tillema, Harm; Leenknecht, Martijn; Segers, Mien

    2011-01-01

    The interest in "assessment for learning" (AfL) has resulted in a search for new modes of assessment that are better aligned to students' learning how to learn. However, with the introduction of new assessment tools, also questions arose with respect to the quality of its measurement. On the one hand, the appropriateness of traditional,…

  13. Design, quality, and quality assurance of solid recovered fuels for the substitution of fossil feedstock in the cement industry.

    Science.gov (United States)

    Sarc, R; Lorber, K E; Pomberger, R; Rogetzer, M; Sipple, E M

    2014-07-01

    This paper describes the requirements for the production, quality, and quality assurance of solid recovered fuels (SRF) that are increasingly used in the cement industry. Different aspects have to be considered before using SRF as an alternative fuel. Here, a study on the quality of SRF used in the cement industry is presented. This overview is completed by an investigation of type and properties of input materials used at waste splitting and SRF production plants in Austria. As a simplified classification, SRF can be divided into two classes: a fine, high-calorific SRF for the main burner, or coarser SRF material with low calorific value for secondary firing systems, such as precombustion chambers or similar systems. In the present study, SRFs coming from various sources that fall under these two different waste fuel classes are discussed. Both SRFs are actually fired in the grey clinker kiln of the Holcim (Slovensko) plant in Rohožnik (Slovakia). The fine premium-quality material is used in the main burner and the coarse regular-quality material is fed to a FLS Hotdisc combustion device. In general, the alternative fuels are used instead of their substituted fossil fuels. For this, chemical compositions and other properties of SRF were compared to hard coal as one of the most common conventional fuels in Europe. This approach allows to compare the heavy metal input from traditional and alternative fuels and to comment on the legal requirements on SRF that, at the moment, are under development in Europe. © The Author(s) 2014.

  14. Numerical simulation of the tip clearance flow in axial turbomachinery; Numerische Simulation der Stroemung im radialen Schaufelspalt axialer Turbomaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Melake, A [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Antriebstechnik

    1997-12-31

    A computer program has been developed to calculate the three-dimensional tip leakage flow in axial turbomachinery based on the Navier-Stokes equation. This program has been applied to investigate the leakage flow within the gap between the blade fip and casing in an annular compressor cascade. A block structured computational mesh has been used in order to resolve the flow details within the gap and the passage flow. Flow characteristics like boundary layer separation, vortex genesis and interaction of the leakage flow with the secondary flow have been investigated and compared with existing experimental data. By varying the incidence angle and the tip gap the above mentioned flow phenomena have been analysed in an annular compressor cascade and a shrouded propfan rotor respectively. Furthermore, the relationship between the total pressure loss, the axial velocity deficit and the divergence of the tip leakage vortex has been investigated. Streamlines, limited streamlines and the critical point theory have been used extensively to analyse the boundary layer separation on the casing and its roll up to form the tip clearance vortex. (orig.). 59 figs., 3 tabs., 110 refs. [Deutsch] Es wurde ein Rechenprogramm zur Berechnung der dreidimensionalen Spaltstroemung im radialen Schaufelspalt axialer Turbomaschinen auf der Basis der Navier-Stokes`schen Gleichungen entwickelt und angewendet. Um die Stroemung innerhalb des Spaltes und der Schaufelpassage besser aufloesen zu koennen, wurde eine blockstrukturierte Netztopologie verwendet. Stroemungseigenschaften wie Grenzschichtabloesung, Entstehung des Spaltwirbels, Interaktion der Spaltstroemung mit der Sekundaerstroemung werden untersucht und mit vorhandenen experimentellen Daten verglichen. Im weiteren werden durch Variation der Inzidenz und der Spaltweite die oben genannten Stroemungsphaenomene an einem axialen Verdichterringgitter und an einem ummantelten Propfan analysiert. Ferner werden die Korrelation zwischen

  15. Implementing a "quality by design" approach to assure the safety and integrity of botanical dietary supplements.

    Science.gov (United States)

    Khan, Ikhlas A; Smillie, Troy

    2012-09-28

    Natural products have provided a basis for health care and medicine to humankind since the beginning of civilization. According to the World Health Organization (WHO), approximately 80% of the world population still relies on herbal medicines for health-related benefits. In the United States, over 42% of the population claimed to have used botanical dietary supplements to either augment their current diet or to "treat" or "prevent" a particular health-related issue. This has led to the development of a burgeoning industry in the U.S. ($4.8 billion per year in 2008) to supply dietary supplements to the consumer. However, many commercial botanical products are poorly defined scientifically, and the consumer must take it on faith that the supplement they are ingesting is an accurate representation of what is listed on the label, and that it contains the purportedly "active" constituents they seek. Many dietary supplement manufacturers, academic research groups, and governmental organizations are progressively attempting to construct a better scientific understanding of natural products, herbals, and botanical dietary supplements that have co-evolved with Western-style pharmaceutical medicines. However, a deficiency of knowledge is still evident, and this issue needs to be addressed in order to achieve a significant level of safety, efficacy, and quality for commercial natural products. The authors contend that a "quality by design" approach for botanical dietary supplements should be implemented in order to ensure the safety and integrity of these products. Initiating this approach with the authentication of the starting plant material is an essential first step, and in this review several techniques that can aid in this endeavor are outlined.

  16. Predicted water quality of oil sands reclamation wetlands : impact of physical design and hydrology

    International Nuclear Information System (INIS)

    2006-01-01

    Although engineered wetlands can be used as treatment systems in the reclamation of oil sands mines, a variety of factors must be considered to improve the biological functioning of many oil sands reclamation landscapes. Key factors in the control of concentrations of dissolved substances include area, depth, shape, surrounding landscape material and contributing water quality and quantity. Seasonal cycles of precipitation and ice cover also require consideration in the planning of wetlands ecosystems. This paper presented details of a model designed to predict constituent concentrations in planned wetlands based on probable inflow and processes. Input variables consisted of key substances and hydrological factors that may be encountered on reclaimed landscapes. The model was constructed to perform sensitivity analyses of wetlands with respect to total dissolved solids (TDS), major ions, and naphthenic acids concentrations. Inputs and assumptions drawn from previous environmental impact assessments completed for proposed and approved oil sands projects were used. Results suggested that wetlands volume is an important factor in the moderation of peak flows and substance decay. The predictions generated by the model suggested that wetlands size, tailings and sandcap placement schedules may be manipulated to achieve desired wetlands salinities. It was observed that the proportion of the watershed covered by specific land types can affect both initial and future concentrations. Long-term climate change that results in 15 per cent more or less runoff was predicted to have little effect on wetlands concentrations, although concentrations may rise during periodic droughts. It was concluded that site-specific modelling and careful planning is needed to achieve desired water quality for the creation of engineered wetlands. 18 refs., 3 tabs., 3 figs

  17. Modeling of turbulent flows in cooling channels of turbo-machineries; Modelisation des ecoulements turbulents dans des canaux de refroidissement de turbomachines

    Energy Technology Data Exchange (ETDEWEB)

    Bidart, A.; Caltagirone, J.P.; Parneix, S. [Laboratoire MASTER-ENSCPB, 33 - Talence (France)

    1997-12-31

    The MASTER laboratory has been involved since several years in the creation and utilization of modeling tools for the prediction of 3-D turbulent flows and heat transfers in turbine blades in order to optimize the cooling systems of turbo-machineries. This paper describes one of the test-cases that has been used for the validation of the `Aquilon` calculation code developed in this aim. Then, the modeling performed with the `Fluent` industrial code in order to evaluate the possible improvements of the Aquilon code, is presented. (J.S.) 5 refs.

  18. Defining process design space for a hydrophobic interaction chromatography (HIC) purification step: application of quality by design (QbD) principles.

    Science.gov (United States)

    Jiang, Canping; Flansburg, Lisa; Ghose, Sanchayita; Jorjorian, Paul; Shukla, Abhinav A

    2010-12-15

    The concept of design space has been taking root under the quality by design paradigm as a foundation of in-process control strategies for biopharmaceutical manufacturing processes. This paper outlines the development of a design space for a hydrophobic interaction chromatography (HIC) process step. The design space included the impact of raw material lot-to-lot variability and variations in the feed stream from cell culture. A failure modes and effects analysis was employed as the basis for the process characterization exercise. During mapping of the process design space, the multi-dimensional combination of operational variables were studied to quantify the impact on process performance in terms of yield and product quality. Variability in resin hydrophobicity was found to have a significant influence on step yield and high-molecular weight aggregate clearance through the HIC step. A robust operating window was identified for this process step that enabled a higher step yield while ensuring acceptable product quality. © 2010 Wiley Periodicals, Inc.

  19. Application of a quality by design approach to the cell culture process of monoclonal antibody production, resulting in the establishment of a design space.

    Science.gov (United States)

    Nagashima, Hiroaki; Watari, Akiko; Shinoda, Yasuharu; Okamoto, Hiroshi; Takuma, Shinya

    2013-12-01

    This case study describes the application of Quality by Design elements to the process of culturing Chinese hamster ovary cells in the production of a monoclonal antibody. All steps in the cell culture process and all process parameters in each step were identified by using a cause-and-effect diagram. Prospective risk assessment using failure mode and effects analysis identified the following four potential critical process parameters in the production culture step: initial viable cell density, culture duration, pH, and temperature. These parameters and lot-to-lot variability in raw material were then evaluated by process characterization utilizing a design of experiments approach consisting of a face-centered central composite design integrated with a full factorial design. Process characterization was conducted using a scaled down model that had been qualified by comparison with large-scale production data. Multivariate regression analysis was used to establish statistical prediction models for performance indicators and quality attributes; with these, we constructed contour plots and conducted Monte Carlo simulation to clarify the design space. The statistical analyses, especially for raw materials, identified set point values, which were most robust with respect to the lot-to-lot variability of raw materials while keeping the product quality within the acceptance criteria. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association.

  20. Designing an integrated model based on the indicators Quality and Earned Value for risk management in Information Technology Projects

    OpenAIRE

    TATLARI, Mohammad Reza; KAZEMİPOOR, Hamed

    2015-01-01

    There are two effective factors on Information Technology (IT) projects risk including quality and earned value so that by controlling these two factors and their increased level in IT projects, the corresponding risk can be decreased. Therefore in present study, an integrated model was designed based on quality and earned value indicators for risk management in IT projects on a new and efficient approach. The proposed algorithm included the steps such as preparing a list of several indicator...

  1. Testing of Selective Laser Melting Turbomachinery Applicable to Exploration Upper Stage

    Science.gov (United States)

    Calvert, Marty; Turpin, Jason; Nettles, Mindy

    2015-01-01

    This task is to design, fabricate, and spin test to failure a Ti6-4 hydrogen turbopump impeller that was built using the selective laser melting (SLM) fabrication process (fig. 1). The impeller is sized around upper stage engine requirements. In addition to the spin burst test, material testing will be performed on coupons that are built with the impeller.

  2. Quality by Design approach for an in situ gelling microemulsion of Lorazepam via intranasal route.

    Science.gov (United States)

    Shah, Vidhi; Sharma, Mukesh; Pandya, Radhika; Parikh, Rajesh K; Bharatiya, Bhavesh; Shukla, Atindra; Tsai, Hsieh-Chih

    2017-06-01

    The present study illustrates the application of the concept of Quality by Design for development, optimization and evaluation of Lorazepam loaded microemulsion containing ion responsive In situ gelator gellan gum and carbopol 934. A novel approach involving interactions between surfactant and polymer was employed to achieve controlled drug release and reduced mucociliary clearance. Microemulsion formulated using preliminary solubility study and pseudo ternary phase diagrams showed significantly improved solubilization capacity of Lorazepam with 54.31±6.07nm droplets size. The effect of oil to surfactant/cosurfactant ratio and concentration of gelling agent on the drug release and viscosity of microemulsion gel (MEG) was evaluated using a 3 2 full factorial design. The gel of optimized formulation (MEG 1 ) showed a drug release up to 6h of 97.32±1.35% of total drug loaded. The change in shear-dependent viscosity for different formulations on interaction with Simulated Nasal Fluid depicts the crucial role of surfactant-polymer interactions on the gelation properties along with calcium ions binding on the polymer chains. It is proposed that the surfactant-polymer interactions in the form of a stoichiometric hydrogen bonding between oxyethylene and carboxylic groups of the polymers used, provides exceptional ME stability and adhesion properties. Compared with the marketed formulation, optimized MEG showed improved pharmacodynamic activity. Ex vivo diffusion studies revealed significantly higher release for MEG compared to microemulsion and drug solution. MEG showed higher flux and permeation across goat nasal mucosa. According to the study, it could be concluded that formulation would successfully provide the rapid onset of action, and decrease the mucociliary clearance due to formation of in situ gelling mucoadhesive system. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Application of fractional factorial design to improve hot smoked Nile Perch (Lates niloticus quality

    Directory of Open Access Journals (Sweden)

    Sokamté, T.A.

    2017-06-01

    Full Text Available The aim of this research was to study the parameters influencing moisture, salt and total phenol content of hot smoked Nile Perch and to compare the influence of processing conditions on its proximate composition and sensory quality. The effect on moisture, salt and total phenol content was investigated using fractional factorial design with seven factors and two levels: X1 for brine concentration, X2 for brining time, X3 for preliminary smoking-drying time, X4 for smoking time, X5 for hot smoking time, X6 for smoking temperature and X7 for hot smoking temperature. A Multiple Linear Regression Analysis was performed to fit the mathematical model to the collected data and the model tested using analysis of variance (ANOVA. Results of ANOVA indicated the good accuracy and highest significance of the mathematical model. The range of total protein and lipid content was 17.96 to 34.34% and 0.87 to 4.43%, respectively. The range of general acceptability of smoked Nile Perch was 4.6 to 8.2 based on 9-point hedonic scale. Based on the results obtained, including the overall acceptability, proximate composition and smoking criteria of finished product, samples produced with the following conditions: brining at 4% for 270min, drying at 30°C for 30min and the smoked time/temperature cycles following: 30°C/120min; 50°C/240min and 80°C/240min was the best and most accepted. The results derived from this study indicate that the fractional factorial design is a useful screening tool for improving industrial smoking process of Nile Perch.

  4. Improving productivity and quality of biodiesel from Chlorella vulgaris SDEC-3M through customized process designs

    International Nuclear Information System (INIS)

    Qi, Feng; Pei, Haiyan; Ma, Guixia; Zhang, Shuo; Mu, Ruimin

    2016-01-01

    Highlights: • Responses of growth and lipid in SDEC-3M to N concentrations were described. • The high lipid accumulation and biomass production were coexisted in buffer period. • Shorting N-deficient culture stage could improve lipid productivity. • A scheme of optimal designs was suggested to improve lipid productivity. • Biodiesels were meet standards and their performances varied with N-deficient time. - Abstract: In this study, temporal variations of microalgae growth and lipid accumulation in response to different nitrogen concentrations in media were investigated and discussed in detail, using a mutant Chlorella vulgaris SDEC-3M as a model. The results show that a short-term of dramatic lipid accumulation and nonsignificant descent of biomass productivities can be concomitant in SDEC-3M during early N-deficient stage (buffer period). It was found that the maximum lipid productivities of 63.52 mg L"−"1 d"−"1 occurred after 24 h N-shift. It means that, obtained lipid productivity under two-stage strategy with 24 h N-deficient stage was approximately three times as high as the maximum one obtained under N-rich condition and the final one obtained during longer N-deficient culture. Batch culture mode, higher light intensity and light/dark cycle in cooperation with N-rich/N-deficient cycle were also suggested as feasible scheme to improve lipid productivity in large scale culture. Additionally, the fatty acid profiles analysis indirectly showed that the properties of biodiesel from SDEC-3M majorly satisfied biodiesel standards. The fuel performances varied with N-deficient culture time, meaning that better combustion performance, oxidation stability, and exhaust emissions level related to longer N-deficient stage, while the biodiesel produced form N-deficient would perform well under low temperature. The results mean that SDEC-3M-derived biodiesels with customized process designs have commercial potential in the aspects of productivity and quality.

  5. Nurses’ perceptions of feedback to nursing teams on quality measurements: An embedded case study design

    NARCIS (Netherlands)

    Giesbers, A.P.M.; Schouteten, R.L.J.; Poutsma, Erik; Heijden, B.I.J.M. van der; Achterberg, T. van

    2016-01-01

    BACKGROUND Providing nursing teams with feedback on quality measurements is used as a quality improvement instrument in healthcare organizations worldwide. Previous research indicated contradictory results regarding the effect of such feedback on both nurses’ well-being and

  6. Nurses' perceptions of feedback to nursing teams on quality measurements: An embedded case study design

    NARCIS (Netherlands)

    Giesbers, A.P.; Schouteten, R.L.; Poutsma, F.; Heijden, B.I. van der; Achterberg, T. van

    2016-01-01

    BACKGROUND: Providing nursing teams with feedback on quality measurements is used as a quality improvement instrument in healthcare organizations worldwide. Previous research indicated contradictory results regarding the effect of such feedback on both nurses' well-being and performance. OBJECTIVES:

  7. TECHNICAL GUIDANCE DOCUMENT: CONSTRUCTION QUALITY MANAGEMENT FOR REMEDIAL ACTION AND REMEDIAL DESIGN WASTE CONTAINMENT SYSTEMS

    Science.gov (United States)

    This Technical Guidance Document is intended to augment the numerous construction quality control and construction quality assurance (CQC and CQA) documents that are available far materials associated with waste containment systems developed for Superfund site remediation. In ge...

  8. 76 FR 53853 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2011-08-30

    ... Action Network (LEAN) v. EPA, No. 02-60991). The issues raised concerned EPA's decision to approve... Ambient Air Quality Standard,'' Memorandum from John S. Seitz, Director, Office of Air Quality Planning...

  9. Defining and improving quality management in Dutch diabetes care groups and outpatient clinics: design of the study

    Science.gov (United States)

    2013-01-01

    Background Worldwide, the organisation of diabetes care is changing. As a result general practices and diabetes teams in hospitals are becoming part of new organisations in which multidisciplinary care programs are implemented. In the Netherlands, 97 diabetes care groups and 104 outpatient clinics are working with a diabetes care program. Both types of organisations aim to improve the quality of diabetes care. Therefore, it is essential to understand the comprehensive elements needed for optimal quality management at organisational level. This study aims to assess the current level of diabetes quality management in both care groups and outpatient clinics and its improvement after providing feedback on their quality management system and tailored support. Methods/design This study is a before-after study with a one-year follow-up comparing the levels of quality management before and after an intervention to improve diabetes quality management. To assess the status of quality management, online questionnaires were developed based on current literature. They consist of six domains: organisation of care, multidisciplinary teamwork, patient centeredness, performance management, quality improvement policy and management strategies. Based on the questionnaires, respondents will receive feedback on their score in a radar diagram and an elucidating table. They will also be granted access to an online toolbox with instruments that proved to be effective in quality of care improvement and with practical examples. If requested, personal support in implementing these tools will be available. After one year quality management will be measured again using the same questionnaire. Discussion This study will reveal a nationwide picture of quality management in diabetes care groups and outpatient clinics in the Netherlands and evaluate the effect of offering tailored support. The operationalisation of quality management on organisational level may be of interest for other countries

  10. Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach.

    Science.gov (United States)

    Bhise, Ketki; Kashaw, Sushil Kumar; Sau, Samaresh; Iyer, Arun K

    2017-06-30

    Cancer is one of the leading causes of death worldwide. There are several hurdles in cancer therapy because of side-effects which limits its usage. Nanoparticulate drug delivery systems have been tested against cancer in a range of scientific studies. In the recent years, advanced research on Nanostructured Lipid Carriers (NLCs) has garnered considerable attention owing to the advantages over their first-generation counterparts, Solid Lipid Nanoparticles (SLN). NLCs facilitate efficient loading of poorly water soluble drugs with simple methods of drug loading. Recently, there is an increased interest in polyphenols because of the evidence of their promising role in prevention of cancer. Polyphenols are produced as secondary metabolites by plants. Their role in prevention of development of tumors through variety of mechanisms and reduction of tumor cell mass has been reported. This article aims to review the science behind development of NLCs and role of polyphenols as promising anticancer agents. Principles of Quality by Design (QbD) have also been explained which are used in formulation-development of many nanoparticles, including NLCs, as reported in literature. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Application of the non lineal dynamics to the design of processes in the administration of quality

    International Nuclear Information System (INIS)

    Domech More, Jesus

    1999-01-01

    The present work thinks about the possibility to apply the techniques from the non lineal dynamics to the one design of processes like a complex but realler tool that the statistical techniques. As study object the process of production of lead containers is used (means of shielding) that are used to carry radioisotopos in the system of vat health. It intends a model of non lineal dynamics of the process that allows to evaluate what so predictable it is the chosen system (entrance control to the matter prevails) and which the one will be behavior average of the same one based in the complex interactions that arise in the relationships client-supplier, operative-machine, supplier-supplier, operative-environment and operative-method. Each one of these interactions constitutes a source of uncertainty in the one I process and he/she has a weight on the temporary dynamics of the characteristic of real quality (homogeneity of the blindaje) in the process

  12. Data Quality Objectives Process for Designation of K-Basins Debris

    International Nuclear Information System (INIS)

    WESTCOTT, J.L.

    2000-01-01

    The U.S. Department of Energy has developed a schedule and approach for the removal of spent fuels, sludge, and debris from the K East (KE) and K West (KW) Basins, located in the 100 Area at the Hanford Site. The project that is the subject of this data quality objective (DQO) process is focused on the removal of debris from the K Basins and onsite disposal of the debris at the Environmental Restoration Disposal Facility (ERDF). This material previously has been dispositioned at the Hanford Low-Level Burial Grounds (LLBGs) or Central Waste Complex (CWC). The goal of this DQO process and the resulting Sampling and Analysis Plan (SAP) is to provide the strategy for characterizing and designating the K-Basin debris to determine if it meets the Environmental Restoration Disposal Facility Waste Acceptance Criteria (WAC), Revision 3 (BHI 1998). A critical part of the DQO process is to agree on regulatory and WAC interpretation, to support preparation of the DQO workbook and SAP

  13. Design, development, and implementation of the Radiological Physics Center's pelvis and thorax anthropomorphic quality assurance phantoms

    International Nuclear Information System (INIS)

    Followill, David S.; Radford Evans, DeeAnn; Cherry, Christopher; Molineu, Andrea; Fisher, Gary; Hanson, William F.; Ibbott, Geoffrey S.

    2007-01-01

    The Radiological Physics Center (RPC) developed two heterogeneous anthropomorphic quality assurance phantoms for use in verifying the accuracy of radiation delivery: one for intensity-modulated radiation therapy (IMRT) to the pelvis and the other for stereotactic body radiation therapy (SBRT) to the thorax. The purpose of this study was to describe the design and development of these two phantoms and to demonstrate the reproducibility of measurements generated with them. The phantoms were built to simulate actual patient anatomy. They are lightweight and water-fillable, and they contain imageable targets and organs at risk of radiation exposure that are of similar densities to their human counterparts. Dosimetry inserts accommodate radiochromic film for relative dosimetry and thermoluminesent dosimetry capsules for absolute dosimetry. As a part of the commissioning process, each phantom was imaged, treatment plans were developed, and radiation was delivered at least three times. Under these controlled irradiation conditions, the reproducibility of dose delivery to the target TLD in the pelvis and thorax phantoms was 3% and 0.5%, respectively. The reproducibility of radiation-field localization was less than 2.5 mm for both phantoms. Using these anthropomorphic phantoms, pelvic IMRT and thoracic SBRT radiation treatments can be verified with a high level of precision. These phantoms can be used to effectively credential institutions for participation in specific NCI-sponsored clinical trials

  14. Value of information analysis for groundwater quality monitoring network design Case study: Eocene Aquifer, Palestine

    Science.gov (United States)

    Khader, A.; McKee, M.

    2010-12-01

    Value of information (VOI) analysis evaluates the benefit of collecting additional information to reduce or eliminate uncertainty in a specific decision-making context. It makes explicit any expected potential losses from errors in decision making due to uncertainty and identifies the “best” information collection strategy as one that leads to the greatest expected net benefit to the decision-maker. This study investigates the willingness to pay for groundwater quality monitoring in the Eocene Aquifer, Palestine, which is an unconfined aquifer located in the northern part of the West Bank. The aquifer is being used by 128,000 Palestinians to fulfill domestic and agricultural demands. The study takes into account the consequences of pollution and the options the decision maker might face. Since nitrate is the major pollutant in the aquifer, the consequences of nitrate pollution were analyzed, which mainly consists of the possibility of methemoglobinemia (blue baby syndrome). In this case, the value of monitoring was compared to the costs of treating for methemoglobinemia or the costs of other options like water treatment, using bottled water or importing water from outside the aquifer. And finally, an optimal monitoring network that takes into account the uncertainties in recharge (climate), aquifer properties (hydraulic conductivity), pollutant chemical reaction (decay factor), and the value of monitoring is designed by utilizing a sparse Bayesian modeling algorithm called a relevance vector machine.

  15. Influence of graphic design of the text on reading quality of pupils with dyslexia

    Directory of Open Access Journals (Sweden)

    Zikl Pavel

    2016-01-01

    Full Text Available The contribution contains research results focused on reading quality of pupils with dyslexia according to the graphic design of the text. Our aim was to prove if commonly recommended graphic text editing has a certain influence on reading speed and occurrence of mistakes of children with dyslexia. The research sample consisted of pupils with dyslexia and a control group then selected in pairs of intact pupils of 4th and 5th class of primary school (in total 150 pupils. For the purpose of data collection there had been a text used in an unfamiliar language (a nonsensical text, which corresponds to the Czech language in its structure; is a part of standardized reading test. There were four text versions prepared for the research which had been modified into frequently recommended modifications for dyslexics (increased font size, a use of bigger gaps between words and also rows, syllables highlight in words and a standard text corresponding to common reading-books. Conclusion depicts a presentation of impacts of individual texts modifications and also subjective opinions of pupils about these texts.

  16. Designing train-speed trajectory with energy efficiency and service quality

    Science.gov (United States)

    Jia, Jiannan; Yang, Kai; Yang, Lixing; Gao, Yuan; Li, Shukai

    2018-05-01

    With the development of automatic train operations, optimal trajectory design is significant to the performance of train operations in railway transportation systems. Considering energy efficiency and service quality, this article formulates a bi-objective train-speed trajectory optimization model to minimize simultaneously the energy consumption and travel time in an inter-station section. This article is distinct from previous studies in that more sophisticated train driving strategies characterized by the acceleration/deceleration gear, the cruising speed, and the speed-shift site are specifically considered. For obtaining an optimal train-speed trajectory which has equal satisfactory degree on both objectives, a fuzzy linear programming approach is applied to reformulate the objectives. In addition, a genetic algorithm is developed to solve the proposed train-speed trajectory optimization problem. Finally, a series of numerical experiments based on a real-world instance of Beijing-Tianjin Intercity Railway are implemented to illustrate the practicability of the proposed model as well as the effectiveness of the solution methodology.

  17. Determining the need for improvement of infant incubator design with quality function deployment

    Science.gov (United States)

    Tarigan, U.; Ginting, R.; Siregar, I.

    2018-02-01

    A Newborns need particular attention because it takes time to adapt to the outside world. In accordance with the standard post-neonatal procedures, newborns should be incorporated into the incubator within a specified period of time according to the infant’s health level. Infant incubator as a medical device used to care for newborns, often get complaints from doctors and child nurses. The complaint indicates consumer dissatisfaction with incubator products in the hospital. Broadly speaking, objection against infant incubators lie in inappropriate designs. To overcome these complaints the researchers apply the method of Quality Function Deployment to determine the characteristics of priority techniques in accordance with the wishes of consumers with it. The primary focus of QFD is to engage customers in the product development process as early as possible, which their needs and desires serve as the starting point of the QFD process. Therefore, QFD is called the voice of customer. The underlying philosophy is that customers are not always satisfied with a product even though the product has been perfectly produced. The results show that the category used as a priority improvement is the additional function of the oxygen cylinder and the size of the door hole. QFD phase one produces technical characteristics of Ergonomy, Features and Cost as critical part determinants.

  18. Quality of Design, Analysis and Reporting of Software Engineering Experiments:A Systematic Review

    OpenAIRE

    By Kampenes, Vigdis

    2007-01-01

    Background: Like any research discipline, software engineering research must be of a certain quality to be valuable. High quality research in software engineering ensures that knowledge is accumulated and helpful advice is given to the industry. One way of assessing research quality is to conduct systematic reviews of the published research literature. Objective: The purpose of this work was to assess the quality of published experiments in software engineering with respect to the validit...

  19. The system of quality assurance of EDF for designing and developing nuclear power plants

    International Nuclear Information System (INIS)

    Vaujour, M.

    As the quality required for a power plant must fulfill at one and the same time, performance, safety and reliability criteria, the quality obtainment needs the establishment of a system of quality assurance: an internal system of arrangement of the organizations involved, measures creating the relations between said organizations, mechanisms of control of the quality organizing, and some statements. The respective roles of EDF and the constructors are defined together with the contractual obligations of the constructors [fr

  20. Preliminary Validation and Verification of TURBO{sub D}ESIGN for S-CO{sub 2} Axial Compressor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Je Kyoung; Lee, Jeong Ik; Ahn, Yoon Han; Kim, Seong Gu [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Yoon, Ho Joon; Addad, Yacine [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

    2012-05-15

    To use the advantages of Supercritical CO{sub 2}(S-CO{sub 2}) Brayton cycle for nuclear power plant, KAIST-Khalifa University joint research team has been focusing on S-CO{sub 2} turbomachinery development. TURBO{sub D}ESIGN code is one of the products of our researches to design a turbomachinery. The major feature of TURBO{sub D}ESIGN is that the formulation is based on the real gas and none of the ideal gas assumption was applied to the code. Thus, TURBO{sub D}ESIGN has high flexibility regarding the type of gases. In this paper, preliminary code validation and verification of TURBO{sub D}ESIGN will be discussed for axial type compressor design

  1. Indoor air quality in 24 California residences designed as high-performance homes

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Mullen, Nasim [Gap, Inc., San Francisco, CA (United States); Singer, Brett [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

    2015-01-01

    Today’s high performance green homes are reaching previously unheard of levels of airtightness and are using new materials, technologies and strategies, whose impacts on Indoor Air Quality (IAQ) cannot be fully anticipated from prior studies. This research study used pollutant measurements, home inspections, diagnostic testing and occupant surveys to assess IAQ in 24 new or deeply retrofitted homes designed to be high performance green buildings in California. Although the mechanically vented homes were six times as airtight as non-mechanically ventilated homes (medians of 1.1 and 6.1 ACH50, n=11 and n=8, respectively), their use of mechanical ventilation systems and possibly window operation meant their median air exchange rates were almost the same (0.30 versus 0.32 hr-1, n=8 and n=8, respectively). Pollutant levels were also similar in vented and unvented homes. In addition, these similarities were achieved despite numerous observed faults in complex mechanical ventilation systems. More rigorous commissioning is still recommended. Cooking exhaust systems were used inconsistently and several suffered from design flaws. Failure to follow best practices led to IAQ problems in some cases. Ambient nitrogen dioxide standards were exceeded or nearly so in four homes that either used gas ranges with standing pilots, or in Passive House-style homes that used gas cooking burners without venting range hoods. Homes without active particle filtration had particle count concentrations approximately double those in homes with enhanced filtration. The majority of homes reported using low-emitting materials; consistent with this, formaldehyde levels were approximately half those in conventional, new CA homes built before 2008. Emissions of ultrafine particles (with diameters <100 nm) were dramatically lower on induction electric cooktops, compared with either gas or resistance electric models. These results indicate that high performance homes can achieve

  2. Analysis of Handling Qualities Design Criteria for Active Inceptor Force-Feel Characteristics

    Science.gov (United States)

    Malpica, Carlos A.; Lusardi, Jeff A.

    2013-01-01

    ratio. While these two studies produced boundaries for acceptable/unacceptable stick dynamics for rotorcraft, they were not able to provide guidance on how variations of the stick dynamics in the acceptable region impact handling qualities. More recently, a ground based simulation study [5] suggested little benefit was to be obtained from variations of the damping ratio for a side-stick controller exhibiting high natural frequencies (greater than 17 rad/s) and damping ratios (greater than 2.0). A flight test campaign was conducted concurrently on the RASCAL JUH-60A in-flight simulator and the ACT/FHS EC-135 in flight simulator [6]. Upon detailed analysis of the pilot evaluations the study identified a clear preference for a high damping ratio and natural frequency of the center stick inceptors. Side stick controllers were found to be less sensitive to the damping. While these studies have compiled a substantial amount of data, in the form of qualitative and quantitative pilot opinion, a fundamental analysis of the effect of the inceptor force-feel system on flight control is found to be lacking. The study of Ref. [6] specifically concluded that a systematic analysis was necessary, since discrepancies with the assigned handling qualities showed that proposed analytical design metrics, or criteria, were not suitable. The overall goal of the present study is to develop a clearer fundamental understanding of the underlying mechanisms associated with the inceptor dynamics that govern the handling qualities using a manageable analytical methodology.

  3. [Application of quality by design in granulation process for Ginkgo leaf tablet (Ⅲ): process control strategy based on design space].

    Science.gov (United States)

    Cui, Xiang-Long; Xu, Bing; Sun, Fei; Dai, Sheng-Yun; Shi, Xin-Yuan; Qiao, Yan-Jiang

    2017-03-01

    In this paper, under the guidance of quality by design (QbD) concept, the control strategy of the high shear wet granulation process of the ginkgo leaf tablet based on the design space was established to improve the process controllability and product quality consistency. The median granule size (D50) and bulk density (Da) of granules were identified as critical quality attributes (CQAs) and potential critical process parameters (pCPPs) were determined by the failure modes and effect analysis (FMEA). The Plackeet-Burmann experimental design was used to screen pCPPs and the results demonstrated that the binder amount, the wet massing time and the wet mixing impeller speed were critical process parameters (CPPs). The design space of the high shear wet granulation process was developed within pCPPs range based on the Box-Behnken design and quadratic polynomial regression models. ANOVA analysis showed that the P-values of model were less than 0.05 and the values of lack of fit test were more than 0.1, indicating that the relationship between CQAs and CPPs could be well described by the mathematical models. D₅₀ could be controlled within 170 to 500 μm, and the bulk density could be controlled within 0.30 to 0.44 g•cm⁻³ by using any CPPs combination within the scope of design space. Besides, granules produced by process parameters within the design space region could also meet the requirement of tensile strength of the ginkgo leaf tablet.. Copyright© by the Chinese Pharmaceutical Association.

  4. Analyzing the effects of thermal comfort and indoor air quality in design studios and classrooms on student performance

    OpenAIRE

    Ranjbar, Ali

    2017-01-01

    Cataloged from PDF version of article. Thesis (M.S.): Bilkent University, Department of Interior Architecture and Environmental Design, İhsan Doğramacı Bilkent University, 2017 Includes bibliographical references (leaves 101-106). The present study aims to evaluate the effects of the different ventilation modes on thermal comfort and indoor air quality in design studios and classrooms. It also investigates its associations with student performance. For this purpose, experimenta...

  5. Design, Integration, and Quality. Teacher Education from the perspective of ProTed, a Norwegian Centre of Excellence in Education

    Directory of Open Access Journals (Sweden)

    Jon Magne Vestøl

    2016-04-01

    Full Text Available Artikkelen tar utgangspunkt i utviklingsarbeid i ProTed, Senter for fremragende lærer­utdanning, og bidrar til å belyse tre begreper av sentral betydning for utforming, utvikling og evaluering av lærerutdanning. Basert på teoriseminarer, strukturerte rapporter og annet empirisk materiale fra ProTeds utviklings­prosjekter presenterer artikkelen tre hovedbegrep: design, integrasjon og kvalitet. Design presenteres som en virksomhet, en dynamisk kompe­tanse­utvikling hvor undervisning transformeres til læring. Kunnskapsintegrasjon forstås som et kjerne-element i et slikt design, og artikkelen utforsker ulike former for integrasjon. Artikkelen presenterer også et perspektiv på kvalitetsvurdering som legger vekt på performa­tive og transformative aspekt ved den kompetanse­utviklingen som genereres gjennom design-virksomheten.Nøkkelord: lærerutdanning, design, integrasjon, kvalitet, ProTedAbstractDrawing on the developmental work of ProTed, a Norwegian Centre of Excellence in Edu­cation, this article contributes to the understanding of three concepts of central importance for the construction, development and evaluation of teacher education. Based on material from theory seminars, structured reports and other data from ProTed’s development projects, the article presents an understanding of the concepts design, integration and quality. Design is presented as an activity, a dynamic competence development where teaching is transformed into learning. Knowledge integration is understood as a core element of this design, and different forms and aspects of integration are explored. An understanding of quality evalu­ation is presented that emphasises performative and transformative aspects of the competence development that is generated through the design activity.Keywords: teacher education, design, integration, quality, ProTed

  6. Summary report on technical experiences from high-temperature helium turbomachinery testing in Germany

    International Nuclear Information System (INIS)

    Weisbrodt, I.A.

    1996-01-01

    In Germany a comprehensive research and development program was initiated in 1968 for a Brayton (closed) cycle power conversion system. The program was for ultimate use with a high temperature, helium cooled nuclear reactor heat source (the HHT project) for electricity generation using helium as the working fluid. The program continued until 1982 in international cooperation with the United States and Switzerland. This document describes the designs and reports the results of testing activities that addressed the development of turbines, compressors, hot gas ducts, materials, heat exchangers and other equipment items for use with a helium working fluid at high temperatures. 67 refs, 34 figs, tabs

  7. Thermodynamic analysis and preliminary design of closed Brayton cycle using nitrogen as working fluid and coupled to small modular Sodium-cooled fast reactor (SM-SFR)

    International Nuclear Information System (INIS)

    Olumayegun, Olumide; Wang, Meihong; Kelsall, Greg

    2017-01-01

    Highlights: • Nitrogen closed Brayton cycle for small modular sodium-cooled fast reactor studied. • Thermodynamic modelling and analysis of closed Brayton cycle performed. • Two-shaft configuration proposed and performance compared to single shaft. • Preliminary design of heat exchangers and turbomachinery carried out. - Abstract: Sodium-cooled fast reactor (SFR) is considered the most promising of the Generation IV reactors for their near-term demonstration of power generation. Small modular SFRs (SM-SFRs) have less investment risk, can be deployed more quickly, are easier to operate and are more flexible in comparison to large nuclear reactor. Currently, SFRs use the proven Rankine steam cycle as the power conversion system. However, a key challenge is to prevent dangerous sodium-water reaction that could happen in SFR coupled to steam cycle. Nitrogen gas is inert and does not react with sodium. Hence, intercooled closed Brayton cycle (CBC) using nitrogen as working fluid and with a single shaft configuration has been one common power conversion system option for possible near-term demonstration of SFR. In this work, a new two shaft nitrogen CBC with parallel turbines was proposed to further simplify the design of the turbomachinery and reduce turbomachinery size without compromising the cycle efficiency. Furthermore, thermodynamic performance analysis and preliminary design of components were carried out in comparison with a reference single shaft nitrogen cycle. Mathematical models in Matlab were developed for steady state thermodynamic analysis of the cycles and for preliminary design of the heat exchangers, turbines and compressors. Studies were performed to investigate the impact of the recuperator minimum terminal temperature difference (TTD) on the overall cycle efficiency and recuperator size. The effect of turbomachinery efficiencies on the overall cycle efficiency was examined. The results showed that the cycle efficiency of the proposed

  8. Multicriteria Decision Analysis in Improving Quality of Design in Femoral Component of Knee Prostheses: Influence of Interface Geometry and Material

    Directory of Open Access Journals (Sweden)

    Ali Jahan

    2015-01-01

    Full Text Available Knee prostheses as medical products require careful application of quality and design tool to ensure the best performance. Therefore, quality function deployment (QFD was proposed as a quality tool to systematically integrate consumer’s expectation to perceived needs by medical and design team and to explicitly address the translation of customer needs into engineering characteristics. In this study, full factorial design of experiment (DOE method was accompanied by finite element analysis (FEA to evaluate the effect of inner contours of femoral component on mechanical stability of the implant and biomechanical stresses within the implant components and adjacent bone areas with preservation of the outer contours for standard Co-Cr alloy and a promising functionally graded material (FGM. The ANOVA revealed that the inner shape of femoral component influenced the performance measures in which the angle between the distal and anterior cuts and the angle between the distal and posterior cuts were greatly influential. In the final ranking of alternatives, using multicriteria decision analysis (MCDA, the designs with FGM was ranked first over the Co-Cr femoral component, but the original design with Co-Cr material was not the best choice femoral component, among the top ranked design with the same material.

  9. Designing bioenergy crop buffers to mitigate nitrous oxide emissions and water quality impacts from agriculture

    Science.gov (United States)

    Gopalakrishnan, G.; Negri, C. M.

    2010-12-01

    There is a strong societal need to evaluate and understand the environmental aspects of bioenergy production, especially due to the significant increases in production mandated by many countries, including the United States. Bioenergy is a land-based renewable resource and increases in production are likely to result in large-scale conversion of land from current uses to bioenergy crop production; potentially causing increases in the prices of food, land and agricultural commodities as well as disruption of ecosystems. Current research on the environmental sustainability of bioenergy has largely focused on the potential of bioenergy crops to sequester carbon and mitigate greenhouse gas (GHG) emissions and possible impacts on water quality and quantity. A key assumption in these studies is that bioenergy crops will be grown in a manner similar to current agricultural crops such as corn and hence would affect the environment similarly. This study presents a systems approach where the agricultural, energy and environmental sectors are considered as components of a single system, and bioenergy crops are used to design multi-functional agricultural landscapes that meet society’s requirements for food, energy and environmental protection. We evaluate the production of bioenergy crop buffers on marginal land and using degraded water and discuss the potential for growing cellulosic bioenergy crops such as miscanthus and switchgrass in optimized systems such that (1) marginal land is brought into productive use; (2) impaired water is used to boost yields (3); clean freshwater is left for other uses that require higher water quality; and (4) feedstock diversification is achieved that helps ecological sustainability, biodiversity, and economic opportunities for farmers. The process-based biogeochemical model DNDC was used to simulate crop yield, nitrous oxide production and nitrate concentrations in groundwater when bioenergy crops were grown in buffer strips adjacent to

  10. Centrifugal compressor design options for small turbochargers

    Energy Technology Data Exchange (ETDEWEB)

    Rodgers, C. [ITC, San Diego (United States)

    1998-07-01

    Evolutionary development of the small turbocharger centrifugal compressor over the past four decades has resulted in a finely honed turbomachinery component satisfying both thermodynamic and economic constraints. At this penultimate stage of development an appraisal was considered timely of the remaining design options that exist to enhance the performance characteristics and cost reduction features. This paper presents the results of an analytical study of various small centrifugal compressor design options, assessed in merit of both aerodynamic and manufacturing cost attributes, together with recommendations for future research avenues. (author)

  11. The quality assurance function with respect to the design and construction of steel structures for pre-stressed nuclear vessels

    International Nuclear Information System (INIS)

    Garrard, R.S.; Salmons, B.H.

    1976-01-01

    The paper deals with experience gained at Hartlepool and Heysham. These Power Station Projects have now passed through the 'enquiry', 'tender' and 'placing-of-order' stages, and are deeply involved at present in the detailed 'design', 'construction' and 'setting-to-work' phases. Quality Assurance in the widest concept has been active throughout, but experience has shown that Quality Assurance Programmes should have played a more positive role, particularly in the early stages. Difficulties have arisen because the prototype nature of the plant was not fully appreciated at the time of Enquiry and Tender. On occasion, manufacture has had to proceed, before detailed design proving was achieved, in order to maintain the Construction Programme. However, in one or two instances, this approach was shown to be false economy as more time was used in rework after all the technical parameters had been established. It is now recognised that a fully integrated Quality Assurance function is one of the essential tools for establishing a viable Programme for the Project, and maintaining Product Quality consistent with Plant Reliability. A description is given in this Paper of the methods which have been developed for the approval of Designs and Manufacturing Procedures, together with Techniques in use to ensure that Quality Requirements are known, understood and implemented. (author)

  12. Quality-by-Design approach to monitor the operation of a batch bioreactor in an industrial avian vaccine manufacturing process.

    Science.gov (United States)

    Largoni, Martina; Facco, Pierantonio; Bernini, Donatella; Bezzo, Fabrizio; Barolo, Massimiliano

    2015-10-10

    Monitoring batch bioreactors is a complex task, due to the fact that several sources of variability can affect a running batch and impact on the final product quality. Additionally, the product quality itself may not be measurable on line, but requires sampling and lab analysis taking several days to be completed. In this study we show that, by using appropriate process analytical technology tools, the operation of an industrial batch bioreactor used in avian vaccine manufacturing can be effectively monitored as the batch progresses. Multivariate statistical models are built from historical databases of batches already completed, and they are used to enable the real time identification of the variability sources, to reliably predict the final product quality, and to improve process understanding, paving the way to a reduction of final product rejections, as well as to a reduction of the product cycle time. It is also shown that the product quality "builds up" mainly during the first half of a batch, suggesting on the one side that reducing the variability during this period is crucial, and on the other side that the batch length can possibly be shortened. Overall, the study demonstrates that, by using a Quality-by-Design approach centered on the appropriate use of mathematical modeling, quality can indeed be built "by design" into the final product, whereas the role of end-point product testing can progressively reduce its importance in product manufacturing. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein.

    Science.gov (United States)

    Rouiller, Yolande; Solacroup, Thomas; Deparis, Véronique; Barbafieri, Marco; Gleixner, Ralf; Broly, Hervé; Eon-Duval, Alex

    2012-06-01

    The production bioreactor step of an Fc-Fusion protein manufacturing cell culture process was characterized following Quality by Design principles. Using scientific knowledge derived from the literature and process knowledge gathered during development studies and manufacturing to support clinical trials, potential critical and key process parameters with a possible impact on product quality and process performance, respectively, were determined during a risk assessment exercise. The identified process parameters were evaluated using a design of experiment approach. The regression models generated from the data allowed characterizing the impact of the identified process parameters on quality attributes. The main parameters having an impact on product titer were pH and dissolved oxygen, while those having the highest impact on process- and product-related impurities and variants were pH and culture duration. The models derived from characterization studies were used to define the cell culture process design space. The design space limits were set in such a way as to ensure that the drug substance material would consistently have the desired quality. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach

    DEFF Research Database (Denmark)

    Leng, Donglei; Thanki, Kaushik; Fattal, Elias

    2018-01-01

    -by-design (QbD) approach was adopted to identify the optimal formulation parameters. The quality target product profile (QTPP) of the LPNs was identified based on risk assessment. Two critical formulation parameters (CFPs) were identified, including the theoretical budesonide loading and the theoretical DOTAP...

  15. Comparative evaluation of three shaft seals proposed for high performance turbomachinery

    Science.gov (United States)

    Hendricks, R. C.

    1982-01-01

    Experimental pressure profiles and leak rate characteristics for three shaft seal prototype model configurations proposed for the space shuttle turbopump were assessed in the concentric and fully eccentric, to point of rub, positions without the effects of rotation. The parallel-cylindrical configuration has moderate to good stiffness with a higher leak rate. It represents a simple concept, but for practical reasons and possible increases in stability, all such seals should be conical-convergent. The three-stepdown-sequential, parallel-cylindrical seal is converging and represents good to possible high stiffness when fluid separation occurs, with a significant decrease in leak rate. Such seals can be very effective. The three-stepdown-sequential labyrinth seal of 33-teeth (i.e., 12-11-10 teeth from inlet to exit) provides excellent leak control but usually has very poor stiffness, depending on cavity design. The seal is complex and not recommended for dynamic control.

  16. Accelerator Quality HTS Dipole Magnet Demonstrator designs for the EuCARD-2, 5 Tesla 40 mm Clear Aperture Magnet

    CERN Document Server

    Kirby, G; Ballarino, A; Bottura, L; Chouika, N; Clement, S; Datskov, V; Fajardo, L; Fleiter, J; Gauthier, R; Lambert, L; Lopes, M; Perez, J; DeRijk, G; Rijllart, A; Rossi, L; Ten Kate, H; Durante, M; Fazilleau, P; Lorin, C; Haro, E; Stenvall, A; Caspi, S; Marchevsky, M; Goldacker, W; Kario, A

    2014-01-01

    Future high-energy accelerators will need very high magnetic fields in the range of 20 T. The EuCARD-2 work-package-10 is a collaborative push to take HTS materials into an accelerator quality demonstrator magnet. The demonstrator will produce 5 T standalone and between 17 T and 20 T, when inserted into the 100 mm aperture of Fresca-2 high field out-sert magnet. The HTS magnet will demonstrate the field strength and field quality that can be achieved. An effective quench detection and protection system will have to be developed to operate with the HTS superconducting materials. This paper presents a ReBCO magnet design using multi strand Roebel cable that develops a stand-alone field of 5 T in a 40 mm clear aperture and discusses the challenges associated with good field quality using this type of material. A selection of magnet designs is presented as result of a first phase of development.

  17. Accelerator Quality HTS Dipole Magnet Demonstrator Designs for the EuCARD-2, 5 Tesla 40 mm Clear Aperture Magnet

    CERN Document Server

    Kirby, G A; Ballarino, A; Bottura, L; Chouika, N; Clement, S; Datskov, V; Fajardo, L; Fleiter, J; Gauthier, R; Gentini, L; Lambert, L; Lopes, M; Perez, J C; de Rijk, G; Rijllart, A; Rossi, L; ten Kate, H; Durante, M; Fazilleau, P; Lorin, C; Härö, E; Stenvall, A; Caspi, S; Marchevsky, M; Goldacker, W; Kario, A

    2015-01-01

    Future high-energy accelerators will need very high magnetic fields in the range of 20 T. The EuCARD-2 work-package-10 is a collaborative push to take HTS materials into an accelerator quality demonstrator magnet. The demonstrator will produce 5 T standalone and between 17 T and 20 T, when inserted into the 100 mm aperture of Fresca-2 high field out-sert magnet. The HTS magnet will demonstrate the field strength and field quality that can be achieved. An effective quench detection and protection system will have to be developed to operate with the HTS superconducting materials. This paper presents a ReBCO magnet design using multi strand Roebel cable that develops a stand-alone field of 5 T in a 40 mm clear aperture and discusses the challenges associated with good field quality using this type of material. A selection of magnet designs is presented as result of a first phase of development.

  18. A hybrid floating brush seal (HFBS) for improved sealing and wear performance in turbomachinery applications

    Science.gov (United States)

    Lattime, Scott Byran

    A conceptually new type of seal has been developed for gas turbine applications which dramatically reduces wear and leakage associated with current labyrinth and brush seal technologies. The Hybrid Floating Brush Seal (HFBS) combines brush seal and film riding face seal technologies to create a hybrid seal that allows both axial and radial excursions of the sealed shaft, while simultaneously eliminating interface surface speeds (friction and heat) between the rotor and the brush material that characterize standard brush seal technology. A simple test rig was designed to evaluate feasibility of the HFBS under relatively low pressures and rotational speeds (50psig, 5krpm). A second test stand was created to study the effects of centrifugal force on bristle deflection. A third test facility was constructed for prototype development and extensive room temperature testing at moderate pressures and fairly high rotational speeds (100psig, 40krpm). This test rig also allowed the evaluation of the HFBS during axial movement of a rotating shaft. An analytical model to predict the effects of centrifugal force on the bristles of a rotating brush seal was developed. Room temperature analysis of the HFBS proved successful for relatively high operating rotational velocities at moderate pressures with very acceptable leakage rates for gas turbine engines. Brush seals were able to track rotor speeds up to 24krpm while maintaining sealing integrity. The HFBS's ability to function under axial shaft displacement and synchronous dynamic radial loading was also proven successful. Hydrodynamic performance of the face seal was proven to provide adequate stiffness and load carrying capacity to keep the brush seal from contacting the face seal at pressure drops across the brush of up to 100psi. Leakage performance over standard brush seal and labyrinth technology was quite dramatic. The HFBS showed its sealing advantage using much higher radial interference between the rotor and the bristle

  19. Numerical investigations on axial and radial blade rubs in turbo-machinery

    Science.gov (United States)

    Abdelrhman, Ahmed M.; Tang, Eric Sang Sung; Salman Leong, M.; Al-Qrimli, Haidar F.; Rajamohan, G.

    2017-07-01

    In the recent years, the clearance between the rotor blades and stator/casing had been getting smaller and smaller prior improving the aerodynamic efficiency of the turbomachines as demand in the engineering field. Due to the clearance reduction between the blade tip and the rotor casing and between rotor blades and stator blades, axial and radial blade rubbing could be occurred, especially at high speed resulting into complex nonlinear vibrations. The primary aim of this study is to address the blade axial rubbing phenomenon using numerical analysis of rotor system. A comparison between rubbing caused impacts of axial and radial blade rubbing and rubbing forces are also aims of this study. Tow rotor models (rotor-stator and rotor casing models) has been designed and sketched using SOILDSWORKS software. ANSYS software has been used for the simulation and the numerical analysis. The rubbing conditions were simulated at speed range of 1000rpm, 1500rpm and 2000rpm. Analysis results for axial blade rubbing showed the appearance of blade passing frequency and its multiple frequencies (lx, 2x 3x etc.) and these frequencies will more excited with increasing the rotational speed. Also, it has been observed that when the rotating speed increased, the rubbing force and the harmonics frequencies in x, y and z-direction become higher and severe. The comparison study showed that axial blade rub is more dangerous and would generate a higher vibration impacts and higher blade rubbing force than radial blade rub.

  20. A NEW APPROACH FOR IMPROVING QUALITY OF WEB APPLICATIONS USING DESIGN PATTERNS

    OpenAIRE

    J. Srikanth R. Savithri

    2012-01-01

    Design patterns are descriptions of communicating objects and classes that are customized to solve a general design problem in a particular context, they describes the problem and its corresponding solution. Professional software engineers always use Design patterns for introducing abstractions in software and by the way they can build complex web applications. The right adoption of Design Patterns while designing web applications can promote the factors like reusability and consistency of th...

  1. Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine.

    Science.gov (United States)

    Tumpa, Anja; Stajić, Ana; Jančić-Stojanović, Biljana; Medenica, Mirjana

    2017-02-05

    This paper deals with the development of hydrophilic interaction liquid chromatography (HILIC) method with gradient elution, in accordance with Analytical Quality by Design (AQbD) methodology, for the first time. The method is developed for olanzapine and its seven related substances. Following step by step AQbD methodology, firstly as critical process parameters (CPPs) temperature, starting content of aqueous phase and duration of linear gradient are recognized, and as critical quality attributes (CQAs) separation criterion S of critical pairs of substances are investigated. Rechtschaffen design is used for the creation of models that describe the dependence between CPPs and CQAs. The design space that is obtained at the end is used for choosing the optimal conditions (set point). The method is fully validated at the end to verify the adequacy of the chosen optimal conditions and applied to real samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Symptom Management & Quality of Life Concept Design | Division of Cancer Prevention

    Science.gov (United States)

    This video covers a variety of practical considerations for developing a symptom management concept for clinical research. Co-sponsored by the National Cancer Institute Symptom Management and Health Related Quality of Life Steering Committee & the International Society for Quality of Life Research. |

  3. The Fuzzy Front End of Experience Design – Considering Ambiguous and Prescribed Qualities

    DEFF Research Database (Denmark)

    Ghellal, Sabiha

    2015-01-01

    . Focusing on the phenomenological world of 21 participants, we analyse triangulated data by distinguishing between a range of more ‘ambiguous’ and ‘prescribed’ qualities of experiences. This case study contributes an example of how considering ambiguous and prescribed qualities of experience materials can...

  4. Impact Evaluation of Quality Assurance in Higher Education: Methodology and Causal Designs

    Science.gov (United States)

    Leiber, Theodor; Stensaker, Bjørn; Harvey, Lee

    2015-01-01

    In this paper, the theoretical perspectives and general methodological elements of impact evaluation of quality assurance in higher education institutions are discussed, which should be a cornerstone of quality development in higher education and contribute to improving the knowledge about the effectiveness (or ineffectiveness) of quality…

  5. A Capabilities Perspective on Education Quality: Implications for Foundation Phase Teacher Education Programme Design

    Science.gov (United States)

    Baxen, Jean; Nsubuga, Yvonne; Botha, Liz Johanson

    2014-01-01

    While governments and communities across the globe are faced with the challenge of providing their citizens with good-quality education, there is lack of consensus on how education quality should be defined. Whereas a great deal has been written about the human capital and human rights approaches, which currently dominate the debate, the potential…

  6. 76 FR 56701 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

    Science.gov (United States)

    2011-09-14

    ....regulations.gov website is an ``anonymous access'' system, which means EPA will not know your identity or...? IV. What is the effect of these actions? V. Statutory and Executive Order Reviews I. What actions is... recorded in EPA's Air Quality System (AQS) database. This review addresses air quality data collected in...

  7. Quality Appraisal of Single-Subject Experimental Designs: An Overview and Comparison of Different Appraisal Tools

    Science.gov (United States)

    Wendt, Oliver; Miller, Bridget

    2012-01-01

    Critical appraisal of the research literature is an essential step in informing and implementing evidence-based practice. Quality appraisal tools that assess the methodological quality of experimental studies provide a means to identify the most rigorous research suitable for evidence-based decision-making. In single-subject experimental research,…

  8. Design of Cycle 3 of the National Water-Quality Assessment Program, 2013-23: Part 2: Science plan for improved water-quality information and management

    Science.gov (United States)

    Rowe, Gary L.; Belitz, Kenneth; Demas, Charlie R.; Essaid, Hedeff I.; Gilliom, Robert J.; Hamilton, Pixie A.; Hoos, Anne B.; Lee, Casey J.; Munn, Mark D.; Wolock, David W.

    2013-01-01

    This report presents a science strategy for the third decade of the National Water-Quality Assessment (NAWQA) Program, which since 1991, has been responsible for providing nationally consistent information on the quality of the Nation's streams and groundwater; how water quality is changing over time; and the major natural and human factors that affect current water quality conditions and trends. The strategy is based on an extensive evaluation of the accomplishments of NAWQA over its first two decades, the current status of water-quality monitoring activities by USGS and its partners, and an updated analysis of stakeholder priorities. The plan is designed to address priority issues and national needs identified by NAWQA stakeholders and the National Research Council (2012) irrespective of budget constraints. This plan describes four major goals for the third decade (Cycle 3), the approaches for monitoring, modeling, and scientific studies, key partnerships required to achieve these goals, and products and outcomes that will result from planned assessment activities. The science plan for 2013–2023 is a comprehensive approach to meet stakeholder priorities for: (1) rebuilding NAWQA monitoring networks for streams, rivers, and groundwater, and (2) upgrading models used to extrapolate and forecast changes in water-quality and stream ecosystem condition in response to changing climate and land use. The Cycle 3 plan continues approaches that have been central to the Program’s long-term success, but adjusts monitoring intensities and study designs to address critical information needs and identified data gaps. Restoration of diminished monitoring networks and new directions in modeling and interpretative studies address growing and evolving public and stakeholder needs for water-quality information and improved management, particularly in the face of increasing challenges related to population growth, increasing demands for water, and changing land use and climate

  9. Extension of quality-by-design concept to the early development phase of pharmaceutical R&D processes.

    Science.gov (United States)

    Csóka, Ildikó; Pallagi, Edina; Paál, Tamás L

    2018-03-27

    Here, we propose the extension of the quality-by-design (QbD) concept to also fit the early development phases of pharmaceuticals by adding elements that are currently widely applied, but not yet included in the QbD model in a structured way. These are the introduction of a 'zero' preformulation phase (i.e., selection of drug substance, possible dosage forms and administration routes based on the evaluated therapeutic need); building in stakeholders' (industry, patient, and regulatory) requirements into the quality target product profile (QTTP); and the use of modern quality management tools during the composition and process design phase [collecting critical quality attributes (CQAs) and selection of CPPs) for (still laboratory-scale) design space (DS) development. Moreover, during industrial scale-up, CQAs (as well as critical process parameters; CPPs) can be changed; however, we recommend that the existing QbD elements are reconsidered and updated after this phase. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Quality by design for herbal drugs: a feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes.

    Science.gov (United States)

    Yan, Binjun; Li, Yao; Guo, Zhengtai; Qu, Haibin

    2014-01-01

    The concept of quality by design (QbD) has been widely accepted and applied in the pharmaceutical manufacturing industry. There are still two key issues to be addressed in the implementation of QbD for herbal drugs. The first issue is the quality variation of herbal raw materials and the second issue is the difficulty in defining the acceptable ranges of critical quality attributes (CQAs). To propose a feedforward control strategy and a method for defining the acceptable ranges of CQAs for the two issues. In the case study of the ethanol precipitation process of Danshen (Radix Salvia miltiorrhiza) injection, regression models linking input material attributes and process parameters to CQAs were built first and an optimisation model for calculating the best process parameters according to the input materials was established. Then, the feasible material space was defined and the acceptable ranges of CQAs for the previous process were determined. In the case study, satisfactory regression models were built with cross-validated regression coefficients (Q(2) ) all above 91 %. The feedforward control strategy was applied successfully to compensate the quality variation of the input materials, which was able to control the CQAs in the 90-110 % ranges of the desired values. In addition, the feasible material space for the ethanol precipitation process was built successfully, which showed the acceptable ranges of the CQAs for the concentration process. The proposed methodology can help to promote the implementation of QbD for herbal drugs. Copyright © 2013 John Wiley & Sons, Ltd.

  11. Rating the methodological quality of single-subject designs and n-of-1 trials: introducing the Single-Case Experimental Design (SCED) Scale.

    Science.gov (United States)

    Tate, Robyn L; McDonald, Skye; Perdices, Michael; Togher, Leanne; Schultz, Regina; Savage, Sharon

    2008-08-01

    Rating scales that assess methodological quality of clinical trials provide a means to critically appraise the literature. Scales are currently available to rate randomised and non-randomised controlled trials, but there are none that assess single-subject designs. The Single-Case Experimental Design (SCED) Scale was developed for this purpose and evaluated for reliability. Six clinical researchers who were trained and experienced in rating methodological quality of clinical trials developed the scale and participated in reliability studies. The SCED Scale is an 11-item rating scale for single-subject designs, of which 10 items are used to assess methodological quality and use of statistical analysis. The scale was developed and refined over a 3-year period. Content validity was addressed by identifying items to reduce the main sources of bias in single-case methodology as stipulated by authorities in the field, which were empirically tested against 85 published reports. Inter-rater reliability was assessed using a random sample of 20/312 single-subject reports archived in the Psychological Database of Brain Impairment Treatment Efficacy (PsycBITE). Inter-rater reliability for the total score was excellent, both for individual raters (overall ICC = 0.84; 95% confidence interval 0.73-0.92) and for consensus ratings between pairs of raters (overall ICC = 0.88; 95% confidence interval 0.78-0.95). Item reliability was fair to excellent for consensus ratings between pairs of raters (range k = 0.48 to 1.00). The results were replicated with two independent novice raters who were trained in the use of the scale (ICC = 0.88, 95% confidence interval 0.73-0.95). The SCED Scale thus provides a brief and valid evaluation of methodological quality of single-subject designs, with the total score demonstrating excellent inter-rater reliability using both individual and consensus ratings. Items from the scale can also be used as a checklist in the design, reporting and critical

  12. On the construction of experimental designs for a given task by jointly optimizing several quality criteria: Pareto-optimal experimental designs.

    Science.gov (United States)

    Sánchez, M S; Sarabia, L A; Ortiz, M C

    2012-11-19

    Experimental designs for a given task should be selected on the base of the problem being solved and of some criteria that measure their quality. There are several such criteria because there are several aspects to be taken into account when making a choice. The most used criteria are probably the so-called alphabetical optimality criteria (for example, the A-, E-, and D-criteria related to the joint estimation of the coefficients, or the I- and G-criteria related to the prediction variance). Selecting a proper design to solve a problem implies finding a balance among these several criteria that measure the performance of the design in different aspects. Technically this is a problem of multi-criteria optimization, which can be tackled from different views. The approach presented here addresses the problem in its real vector nature, so that ad hoc experimental designs are generated with an algorithm based on evolutionary algorithms to find the Pareto-optimal front. There is not theoretical limit to the number of criteria that can be studied and, contrary to other approaches, no just one experimental design is computed but a set of experimental designs all of them with the property of being Pareto-optimal in the criteria needed by the user. Besides, the use of an evolutionary algorithm makes it possible to search in both continuous and discrete domains and avoid the need of having a set of candidate points, usual in exchange algorithms. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Rock quality designation of the hydraulic properties in the near field of a final repository for spent nuclear fuel

    International Nuclear Information System (INIS)

    Carlsson, Hans; Carlsson, Leif; Pusch, Roland

    1989-06-01

    Quality assurance of a final repository for spent nuclear fuel requires detailed information on the characteristics of the rock, backfill, canisters and the waste itself. Furthermore, and of fundamental importance, is the knowledge of the behaviour of the integrated system of the waste and the different barriers. The in-situ characteristics of the rock must therefore be assessed and their influence on and interactions with the remaining barriers must be predicted and verified. A rock quality designation process of the hydraulic properties in the near-field is out-lined both for the KBS-3 system as well as for the WP-cave system. The process, once updated and approved, will be included in a Quality Assurance Program for the final repository for spent nuclear fuel. Some of the available methods for the near-field designation process are presented as well as techniques that need further development or are not developed at all. Finally, a presentation is given of a generic designation process of the KBS-3 and WP-cave repository systems in the previously investigated area in Central Sweden, where the final repository for reactor waste, SFR, is located. Geological and hydrogeological data are here at hand and it is therefore possible to carry out a simulation of how the designation process would be accomplished. (authors) (72 figs., 12 tabs., 43 refs.)

  14. Implementation of a quality assurance system for the design and manufacturing of fuel assembly MTR-plate type

    International Nuclear Information System (INIS)

    Koll, J.H.

    1987-01-01

    Since more than 30 years ago, fuel assemblies (FA) of the MTR-Plate type, for research reactors, have been developed and produced using well known technologies, with different methods for the design, manufacturing, quality control and subsequent verification of FA behaviour, as well as of the design data. The FA and its reliability has been improved through the recycling of the obtained information. No nuclear accidents or major incidents have taken place that can be blamed to FA due to design, manufacturing or its use. Since the 70's, the use of Quality Assurance methodology has been increased, especially for Nuclear Power Plants, in order to ensure safety for these reactors. The use of QA for reactors for research, testing or other uses, has also been steadily increased, not only due to safety reasons, but also because of its convenience for a good operation, being presently a common requirement of the operator of the installation. Herewith is described the way the QA system that has been developed for the design, manufacturing, quality control and supply of MTR-plate type FA, at the Development Section of the Argentine Atomic Energy Commission (CNEA). (Author)

  15. Quality assurance of analytical, scientific, and design computer programs for nuclear power plants

    International Nuclear Information System (INIS)

    1994-06-01

    This Standard applies to the design and development, modification, documentation, execution, and configuration management of computer programs used to perform analytical, scientific, and design computations during the design and analysis of safety-related nuclear power plant equipment, systems, structures, and components as identified by the owner. 2 figs

  16. Quality assurance of analytical, scientific, and design computer programs for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-06-01

    This Standard applies to the design and development, modification, documentation, execution, and configuration management of computer programs used to perform analytical, scientific, and design computations during the design and analysis of safety-related nuclear power plant equipment, systems, structures, and components as identified by the owner. 2 figs.

  17. Nurses' perceptions of feedback to nursing teams on quality measurements: An embedded case study design.

    Science.gov (United States)

    Giesbers, A P M Suzanne; Schouteten, Roel L J; Poutsma, Erik; van der Heijden, Beatrice I J M; van Achterberg, Theo

    2016-12-01

    Providing nursing teams with feedback on quality measurements is used as a quality improvement instrument in healthcare organizations worldwide. Previous research indicated contradictory results regarding the effect of such feedback on both nurses' well-being and performance. Building on the Job Demands-Resources model this study explores: (1) whether and how nurses' perceptions of feedback on quality measurements (as a burdening job demand or rather as an intrinsically or extrinsically motivating job resource) are respectively related to nurses' well-being and performance; and (2) whether and how team reflection influences nurses' perceptions. An embedded case study. Four surgical wards within three different acute teaching-hospital settings in the Netherlands. During a period of four months, the nurses on each ward were provided with similar feedback on quality measurements. After this period, interviews with eight nurses and the ward manager for each ward were conducted. Additionally, observational data were collected from three oral feedback moments on each of the participating wards. The data revealed that individual nurses perceive the same feedback on quality measurements differently, leading to different effects on nurses' well-being and performance: 1) feedback can be perceived as a job demand that pressures nurses to improve the results on the quality measurements; 2) feedback can be perceived as an extrinsically motivating job resource, that is instrumental to improve the results on quality measurements; 3) feedback can be perceived as an intrinsically motivating job resource that stimulates nurses to improve the results on the quality measurements; and 4) feedback can be perceived neither as a job demand, nor as a job resource, and has no effect on nurses' well-being and performance. Additionally, this study indicates that team reflection after feedback seems to be very low in practice, while our data also provides evidence that nursing teams using the

  18. An integrated, quality by design (QbD) approach for design, development and optimization of orally disintegrating tablet formulation of carbamazepine.

    Science.gov (United States)

    Mishra, Saurabh M; Rohera, Bhagwan D

    2017-11-01

    The objective of the present study was to design and develop a formulation for orally disintegrating tablets (ODTs) of carbamazepine using quality by design principles. The target product profile (TPP) and quality target product profile (QTPP) of ODTs were identified. Risk assessment was carried out by leveraging prior knowledge and experience to define the criticality of factors based on their impact by Ishikawa fishbone diagram and preliminary hazard analysis tool. Box-Behnken response surface methodology was used to study the effect of critical factors on various attributes of ODTs. The independent factors selected were compression pressure (X 1 ), concentration of sublimating agent (volatile material) (X 2 ), disintegrant concentration (X 3 ) and the responses were tablet crushing strength, tablet porosity, disintegration time, water absorption time, tablet friability and drug dissolution. ANOVA and lack of fit test illustrated that selected independent variables had significant effect on the response variables, and excellent correlation was observed between actual and predicted values. Optimization by desirability function indicated that compression pressure, X 1 (1534 lbs), ammonium bicarbonate concentration, X 2 (7.68%) and Kollidon ® CL-SF concentration, X 3 (6%) were optimum to prepare ODT formulation of carbamazepine of desired attributes complying with QTPP. Thus, in the present study, a high level of assurance was established for ODT product quality and performance.

  19. Heating, Ventilation and Air-Conditioning Systems, Part of Indoor Air Quality Design Tools for Schools

    Science.gov (United States)

    The main purposes of a Heating, Ventilation, and Air-Conditioning system are to help maintain good indoor air quality through adequate ventilation with filtration and provide thermal comfort. HVAC systems are among the largest energy consumers in schools.

  20. 75 FR 42018 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-07-20

    ... makes the situation worse. Retroactive relief would likely impose large costs on the States, which would... emission control measures, monitoring, and reporting; include provisions for air quality modeling; and...

  1. 75 FR 22047 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-04-27

    ... situation worse. Retroactive relief would likely impose large costs on the States, which would face fines... air quality modeling; and provide for public and local agency participation in planning and emission...

  2. 75 FR 8871 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-02-26

    ... proposed solution only makes the situation worse. Retroactive relief would likely impose large costs on the... measures, monitoring, and reporting; includes provisions for air quality modeling; and provides for public...

  3. Cavitation instabilities and rotordynamic effects in turbopumps and hydroturbines turbopump and inducer cavitation, experiments and design

    CERN Document Server

    Salvetti, Maria

    2017-01-01

    The book provides a detailed approach to the physics, fluid dynamics, modeling, experimentation and numerical simulation of cavitation phenomena, with special emphasis on cavitation-induced instabilities and their implications on the design and operation of high performance turbopumps and hydraulic turbines. The first part covers the fundamentals (nucleation, dynamics, thermodynamic effects, erosion) and forms of cavitation (attached cavitation, cloud cavitation, supercavitation, vortex cavitation) relevant to hydraulic turbomachinery, illustrates modern experimental techniques for the characterization, visualization and analysis of cavitating flows, and introduces the main aspects of the hydrodynamic design and performance of axial inducers, centrifugal turbopumps and hydo-turbines. The second part focuses on the theoretical modeling, experimental analysis, and practical control of cavitation-induced fluid-dynamic and rotordynamic instabilities of hydraulic turbomachinery, with special emphasis on cavitating...

  4. Requirements for the quality assurance of design, planning and construction for power plants

    International Nuclear Information System (INIS)

    Edelmann, J.

    1981-01-01

    One of the main points of effective quality planning and quality assurance are the organizational conditions. The basic foundation is a development organization with a clear definition of tasks and responsibilities as well as determination of the information flow. Here the dividing of the tasks is to be carried out in a manner where the number of transitions - in particular error-critical transitions - between the individual organization units are minimized. (orig.) [de

  5. An Application of Green Quality Function Deployment to Designing an Air Conditioner

    OpenAIRE

    Peetam Kumar Dehariya; Dr. Devendra Singh Verma

    2015-01-01

    The paper tackles a systematic and operational approach to Green Quality Function Deployment (GQFD), a customer oriented survey based quality management system with regular improvement in product development. GQFD shows balance between product development and environmental protection. GQFD is not used to determine their attributes and their levels. GQFD captures what product developers “think” would best satisfy customer needs considering Environmental factor. This research used A...

  6. Environmental radiation control and quality management system in design and operation of sealed radioactive sources

    International Nuclear Information System (INIS)

    Hussein, A.Z.

    2007-01-01

    New environmental regulations and radiation safety standards are being implemented almost daily to ensure radiation safety, in particular for practices causing exposures to undue radiation doses. A particular emphasis of real challenge for organizations and users of radiation sources has to be for proper radiological safety assessment and is becoming cost effectively to be prepared for auditing. Special concern for the environment is of global . nature, and hence environmental auditing has been and will continue to be an essential practice for improving the environment and for meeting the relevant regulations and standards. In general, most facilities that deal with radioactive sources undertake strict safety measures in terms of personnel radiation protection, handling procedures and security. Hence, those measures should comply with the requirements of the environmental protection standards. Accordingly, a successful quality management system must balance realities of organization and personnel in achieving quality objectives. Organizational principles are found in the technical aspects of' quality management, such as, charting, requirements, measurements, procedures, ... , etc. Human principles are found in the communication side of quality management (e.g. meetings, ,decision making, ,teams, ... , etc). The quality management must understand and balance skills needed to blend them together. Large gamma irradiators present a high potential radiation hazard to the surrounding environment, since the amount of radioactivity is of the order of (P Bq) and a very high dose rates are produced during irradiation. Application of environmental radiation control deemed by regulatory authority and a proper quality management system by the utility would serve public health and safety

  7. Trends in the design, construction and operation of green roofs to improve the rainwater quality. State of the art

    Directory of Open Access Journals (Sweden)

    Jair Andrés Morales Mojica

    2017-07-01

    Full Text Available The green roofs appear as technology for the improvement water quality. This article identifies trends in the conditions of design, construction and operation of green roofs, which aim is to improve the quality of rainwater. A literature review was carried out in order to collect 45 original research papers from databases as Scopus, Science Direct, and Redalyc. From the information collected trends in increments and reductions in the concentrations of the main water quality parameters, seasons of the year with the best results, types of green roofs , types of substrate and most common components, construction trends (dimensions, inclination, Materials and layers and vegetation used in these systems have been determined. The results show that green roofs have the ability to neutralize acid rain. Extensive type roofs are the ones most commonly used, due to its characteristics of construction, functionality and low maintenance requirements.

  8. Designing and implementing a Quality Broker: the GeoViQua experience

    Science.gov (United States)

    Papeschi, Fabrizio; Bigagli, Lorenzo; Masò, Joan; Nativi, Stefano

    2014-05-01

    GeoViQua (QUAlity aware VIsualisation for the Global Earth Observation System of Systems) is an FP7 project aiming at complementing the Global Earth Observation System of Systems (GEOSS) with rigorous data quality specifications and quality-aware capabilities, in order to improve reliability in scientific studies and policy decision-making. GeoViQua main scientific and technical objective is to enhance the GEOSS Common Infrastructure (GCI) providing the user community with innovative quality-aware search and visualization tools, which will be integrated in the GEOPortal, as well as made available to other end-user interfaces. To this end, GeoViQua will promote the extension of the current standard metadata for geographic information with accurate and expressive quality indicators. Employing and extending several ISO standards such as 19115, 19157 and 19139, a common set of data quality indicators has been selected to be used within the project. The resulting work, in the form of a data model, is expressed in XML Schema Language and encoded in XML. Quality information can be stated both by data producers and by data users, actually resulting in two conceptually distinct data models, the Producer Quality model and the User Quality model (or User Feedback model). GeoViQua architecture is built on the brokering approach successfully experimented within the EuroGEOSS project and realized by the GEO DAB (Discovery and Access Broker) which is part of the GCI. The GEO DAB allows for harmonization and distribution in a transparent way for both users and data providers. This way, GeoViQua can effectively complement and extend the GEO DAB obtaining a Quality augmentation Broker (DAB-Q) which plays a central role in ensuring the consistency of the Producer and User quality models. The GeoViQua architecture also includes a Feedback Catalog, a particular service brokered by the DAB-Q which is dedicated to the storage and discovery of user feedbacks. A very important issue

  9. Application of quality function deployment for designing and developing a curriculum for Industrial Engineering at Prince of Songkla University

    Directory of Open Access Journals (Sweden)

    Nirachara Boonyanuwat

    2008-05-01

    Full Text Available A Quality Function Deployment (QFD technique is used to design a curriculum for Industrial Engineering (IE at Prince of Songkla University (PSU. This paper shows a systematical step-by-step application of the QFD. This analysis focuses both on external evaluators of the university, companies that hire graduates and students’ parents, and internal evaluators of the university, the student themselves and faculty. Survey data from 232 stakeholders were used in the QFD analysis in order to identify the requirements most valued by them. Results indicate that the stakeholders are looking for the graduates’ abilities in the area of productivity improvement, knowledge application, production planning and control, quality management and control, and manufacturing management. Further, the QFD is used to translate the key requirements into an effective curriculum. It can be concluded that the QFD is a useful tool for designing a curriculum for higher educational institutions.

  10. Ranking factors involved in product design using a hybrid model of Quality Function Deployment, Data Envelopment Analysis and TOPSIS technique

    Directory of Open Access Journals (Sweden)

    Davood Feiz

    2014-08-01

    Full Text Available Quality function deployment (QFD is one such extremely important quality management tool, which is useful in product design and development. Traditionally, QFD rates the design requirements (DRs with respect to customer requirements, and aggregates the rating to get relative importance score of DRs. An increasing number of studies emphasize on the need to incorporate additional factors, such as cost and environmental impact, while calculating the relative importance of DRs. However, there are different methodologies for driving the relative importance of DRs, when several additional factors are considered. TOPSIS (technique for order preferences by similarity to ideal solution is suggested for the purpose of the research. This research proposes new approach of TOPSIS for considering the rating of DRs with respect to CRs, and several additional factors, simultaneously. Proposed method is illustrated using by step-by-step procedure. The proposed methodology was applied for the Sanam Electronic Company in Iran.

  11. Fluid machinery application, selection, and design

    CERN Document Server

    Wright, Terry

    2013-01-01

    Published nearly a decade ago, Fluid Machinery: Performance, Analysis, and Design quickly became popular with students, professors, and professionals because of its comprehensive and comprehensible introduction to the fluid mechanics of turbomachinery. Renamed to reflect its wider scope and reorganized content, this second edition provides a more logical flow of information that will enhance understanding. In particular, it presents a consistent notation within and across chapters, updating material when appropriate. Although the authors do account for the astounding growth in the field of com

  12. Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

    Directory of Open Access Journals (Sweden)

    Karimi K

    2016-10-01

    Full Text Available Keyhaneh Karimi, Edina Pallagi, Piroska Szabó-Révész, Ildikó Csóka, Rita Ambrus Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary Abstract: Pulmonary drug delivery of ciprofloxacin hydrochloride offers effective local antibacterial activity and convenience of easy application. Spray drying is a trustworthy technique for the production of ciprofloxacin hydrochloride microparticles. Quality by design (QbD, an up-to-date regulatory-based quality management method, was used to predict the final quality of the product. According to the QbD-based theoretical preliminary parameter ranking and priority classification, dry powder inhalation formulation tests were successfully performed in practice. When focusing on the critical parameters, the practical development was more effective and was in correlation with our previous findings. Spray drying produced spherical microparticles. The dry powder formulations prepared were examined by particle size analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimetry, and in vitro drug release and aerodynamic particle size analyses were also performed. These formulations showed an appropriate particle size ranging between 2 and 4 µm and displayed an enhanced aerosol performance with fine particle fraction up to 80%. Keywords: antibiotic, carrier-free formulation, quality by design, aerodynamic evaluation, dry powder for inhalation

  13. Optimal Design of TCR/FC in Electric Arc Furnaces for Power Quality Improvement in Power Systems

    Directory of Open Access Journals (Sweden)

    Mahdi TORABIAN ESFAHANI

    2009-12-01

    Full Text Available Electric Arc Furnaces (EAFs are unbalanced, nonlinear and time varying loads, which can cause many problems in the power system quality. As the use of arc furnace loads increases in industry, the importance of the power quality problems also increase. So in order to optimize the usages of electric power in EAFs, it is necessary to minimize the effects of arc furnace loads on power quality in power systems as much as possible. Therefore, in this paper, design and simulation of an electric plant supplying an arc furnace is considered. For this purpose, a three phase arc furnace model, which can simulate all the mentioned power quality indices, is developed based on Hyperbolic -Exponential model (V-I model. Then by considering the high changes of reactive power and voltage flicker of nonlinear furnace load, a thyristor controlled reactor compensation with fixed capacitor (TCR/FC are designed and simulated. In this procedure, the reactive power is measured so that maximum speed and accuracy are achieved. Finally, simulation results verify the accuracy of the load modelling and show the effectiveness of the proposed TCR/FC model for reactive compensating of the EAF.

  14. Image-rotating cavity designs for improved beam quality in nanosecond optical parametric oscillators

    International Nuclear Information System (INIS)

    Smith, Arlee V.; Bowers, Mark S.

    2001-01-01

    We show by computer simulation that high beam quality can be achieved in high-energy, nanosecond optical parametric oscillators by use of image-rotating resonators. Lateral walk-off between the signal and the idler beams in a nonlinear crystal creates correlations across the beams in the walk off direction, or equivalently, creates a restricted acceptance angle. These correlations can improve the beam quality in the walk-off plane. We show that image rotation or reflection can be used to improve beam quality in both planes. The lateral walk-off can be due to birefringent walk-off in type II mixing or to noncollinear mixing in type I or type II mixing

  15. Design, Certification, and Deployment of the Colorimetric Water Quality Monitoring Kit (CWQMK)

    Science.gov (United States)

    Gazda, Daniel B.; Nolan, Daniel J.; Rutz, Jeff A.; Schultz, John R.; Siperko, Lorraine M.; Porter, Marc D.; Lipert, Robert J.; Flint, Stephanie M.; McCoy, J. Torin

    2010-01-01

    In August 2009, an experimental water quality monitoring kit based on Colorimetric Solid Phase Extraction (CSPE) technology was delivered to the International Space Station (ISS) aboard STS-128/17A. The kit, called the Colorimetric Water Quality Monitoring Kit (CWQMK), was flown and deployed as a Station Development Test Objective (SDTO) experiment on the ISS. The goal of the SDTO experiment is to evaluate the acceptability of CSPE technology for routine water quality monitoring on the ISS. This paper provides an overview of the SDTO experiment, as well as a detailed description of the CWQMK hardware and a summary of the testing and analysis conducted to certify the CWQMK for use on the ISS. The initial results obtained from the SDTO experiment are also reported and discussed in detail

  16. Conceptual framework for potential implementations of multi criteria decision making (MCDM) methods for design quality assessment

    NARCIS (Netherlands)

    Harputlugil, T.; Prins, M.; Tanju Gültekin, A.; Ilker Topçu, Y.

    2011-01-01

    Architectural design can be considered as a process influenced by many stakeholders, each of which has different decision power. Each stakeholder might have his/her own criteria and weightings depending on his/her own perspective and role. Hence design can be seen as a multi-criteria decision making

  17. Conceptual framework for potential implementations of multicriteria decision making (MCDM) methods for design quality assesment

    NARCIS (Netherlands)

    Hartpulugil, T.; Prins, M.; Gultekin, A.T.; Topcu, Y.L.

    2011-01-01

    Architectural design can be considered as a process influenced by many stakeholders, each of which has different decision power. Each stakeholder might have his/her own criteria and weightings depending on his/her own perspective and role. Hence design can be seen as a multi-criteria decision making

  18. A User-Centered Educational Modeling Language Improving the Controllability of Learning Design Quality

    Science.gov (United States)

    Zendi, Asma; Bouhadada, Tahar; Bousbia, Nabila

    2016-01-01

    Semiformal EMLs are developed to facilitate the adoption of educational modeling languages (EMLs) and to address practitioners' learning design concerns, such as reusability and readability. In this article, SDLD (Structure Dialogue Learning Design) is presented, which is a semiformal EML that aims to improve controllability of learning design…

  19. The Customer Flow Toolkit: A Framework for Designing High Quality Customer Services.

    Science.gov (United States)

    New York Association of Training and Employment Professionals, Albany.

    This document presents a toolkit to assist staff involved in the design and development of New York's one-stop system. Section 1 describes the preplanning issues to be addressed and the intended outcomes that serve as the framework for creation of the customer flow toolkit. Section 2 outlines the following strategies to assist in designing local…

  20. 77 FR 5210 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

    Science.gov (United States)

    2012-02-02

    .... SUMMARY: EPA is proposing to determine, pursuant to the Clean Air Act (CAA), that the bi-state St. Louis... replacement monitor be combined. Table 3--Design Values for Incomplete Data Monitors Compared to Highest... design values are used to compare against the NAAQS. Table 3 illustrates that the Arnold and Tenbrook and...