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Sample records for tunnelling proteins including

  1. Cotranslational Protein Folding inside the Ribosome Exit Tunnel

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    Ola B. Nilsson

    2015-09-01

    Full Text Available At what point during translation do proteins fold? It is well established that proteins can fold cotranslationally outside the ribosome exit tunnel, whereas studies of folding inside the exit tunnel have so far detected only the formation of helical secondary structure and collapsed or partially structured folding intermediates. Here, using a combination of cotranslational nascent chain force measurements, inter-subunit fluorescence resonance energy transfer studies on single translating ribosomes, molecular dynamics simulations, and cryoelectron microscopy, we show that a small zinc-finger domain protein can fold deep inside the vestibule of the ribosome exit tunnel. Thus, for small protein domains, the ribosome itself can provide the kind of sheltered folding environment that chaperones provide for larger proteins.

  2. The ribosomal protein uL22 modulates the shape of the nascent protein exit tunnel

    DEFF Research Database (Denmark)

    Wekselman, I.; Zimmerman, E.; Davidovich, C.

    2017-01-01

    Nascent proteins progress through an elongated tunnel until theyexit from the ribosome. Biochemical, genetic and structural stud-ies have shown that the tunnel is not just a passive path, but alsohas regulatory properties. Erythromycin is a clinically usefulantibiotic that binds to an rRNA pocket...... and specific sequences within nascent chains trigger confor-mational rearrangements in the exit tunnel that are essential forthe translation of specific genes...

  3. Hydrogen tunneling links protein dynamics to enzyme catalysis.

    Science.gov (United States)

    Klinman, Judith P; Kohen, Amnon

    2013-01-01

    The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and verify. Here, we show how the quantum mechanical hydrogen tunneling associated with enzymatic C-H bond cleavage provides a unique window into the necessity of protein dynamics for achieving optimal catalysis. Experimental findings support a hierarchy of thermodynamically equilibrated motions that control the H-donor and -acceptor distance and active-site electrostatics, creating an ensemble of conformations suitable for H-tunneling. A possible extension of this view to methyl transfer and other catalyzed reactions is also presented. The impact of understanding these dynamics on the conceptual framework for enzyme activity, inhibitor/drug design, and biomimetic catalyst design is likely to be substantial.

  4. Conformational Control of Electron Tunneling in Redox Proteins: Sulfite Oxidase

    Science.gov (United States)

    Balabin, Ilya; Kawatsu, Tsutomu; Beratan, David

    2004-03-01

    Many redox proteins mediate electron transfer over large (10-25A) distances, with the reaction rate being, in some cases, remarkably sensitive to the protein structure and dynamics (e.g., Science 290, 114-117 (2000)). These properties make redox proteins excellent candidates for molecular electronics applications. Sulfite oxidase (SO) is a molybdenum-containing electron-transfer enzyme that catalyzes the conversion of sulfite to sulfate. The enzyme consists of two domains, one hosting a molybdopterin moiety, which receives an electron from sulfite, and the other hosting a heme, from which electrons travels to cytochrome c. The domains are connected together by a flexible link, which allows for the domains to move relative to each other. This motion is believed to control electron transfer from the molybdopterin to the heme, which is only possible when the enzyme assumes a closed conformation (the two domains are in contact with each other). The only available crystallographic structure of SO (PDB code 1SOX) characterizes an open conformation, when the two domains are separated. Classical molecular dynamics (MD) simulations of the enzyme in solvent, combined with semi-empirical quantum chemistry calculations, were performed to identify possible closed conformations of SO and to investigate the electron transfer rate in these conformations. Steered MD simulations supplemented by analytical modeling were used to characterize kinetics of conformational transitions, particularly opening and closing of the enzyme, which controls the electron tunneling rate.

  5. A New Circuit Model for Spin-Torque Oscillator Including Perpendicular Torque of Magnetic Tunnel Junction

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    Hyein Lim

    2013-01-01

    Full Text Available Spin-torque oscillator (STO is a promising new technology for the future RF oscillators, which is based on the spin-transfer torque (STT effect in magnetic multilayered nanostructure. It is expected to provide a larger tunability, smaller size, lower power consumption, and higher level of integration than the semiconductor-based oscillators. In our previous work, a circuit-level model of the giant magnetoresistance (GMR STO was proposed. In this paper, we present a physics-based circuit-level model of the magnetic tunnel junction (MTJ-based STO. MTJ-STO model includes the effect of perpendicular torque that has been ignored in the GMR-STO model. The variations of three major characteristics, generation frequency, mean oscillation power, and generation linewidth of an MTJ-STO with respect to the amount of perpendicular torque, are investigated, and the results are applied to our model. The operation of the model was verified by HSPICE simulation, and the results show an excellent agreement with the experimental data. The results also prove that a full circuit-level simulation with MJT-STO devices can be made with our proposed model.

  6. On the early history of field emission including attempts of tunneling spectroscopy

    Science.gov (United States)

    Kleint, C.

    1993-04-01

    Field emission is certainly one of the oldest surface science techniques, its roots reaching back about 250 years to the time of enlightenment. An account of very early studies and of later work is given but mostly restricted to Leipzig and to pre-Müllerian investigations. Studies of field emission from metal tips were carried out in the 18th century by Johann Heinrich Winkler who used vacuum pumps built by Jacob Leupold, a famous Leipzig mechanic. A short account of the career of Winkler will be given and his field emission experiments are illustrated. Field emission was investigated again in Leipzig much later by Julius Edgar Lilienfeld who worked on the improvement of X-ray tubes. He coined the terms ‘autoelektronische Entladung’ of ‘Äona-Effekt’ in 1922, and developed degassing procedures which are very similar to modern ultra-high vacuum processing. A pre-quantum mechanical explanation of the field emission phenomena was undertaken by Walter Schottky. Cunradi (1926) tried to measure temperature changes during field emission. Franz Rother, in a thesis (1914) suggested by Otto Wiener, dealt with the distance dependence of currents in vacuum between electrodes down to 20 nm. His habilitation in 1926 was an extension of his early work but now with field emission tips as a cathode. We might look at his measurements of the field emission characteristics in dependence on distance as a precursor to modern tunneling spectroscopy as well.

  7. A carpal tunnel grading system including combined sensory index-diagnosed mild cases: Relation to presenting features and outcomes.

    Science.gov (United States)

    Zeidman, Lawrence A; Pandey, Dilip K

    2018-01-01

    Prior studies have demonstrated superiority of the combined sensory index (CSI) algorithm in diagnosing mild carpal tunnel syndrome (CTS) and have compared presenting symptoms to CTS grade. However, CTS symptoms, signs, and outcomes, including CSI-diagnosed cases, have not been compared with CTS grade. We retrospectively studied 294 CTS hands from 2010 to 2013; stratified them into mild, moderate, and severe grades; and analyzed the association between CTS grade and presenting symptoms/signs and outcomes. Sensorimotor symptoms (P = 0.017) and signs (P < 0.001) were significantly associated with CTS grade. Regardless of CTS grade, 94% of hands improved with surgery compared with 42% with conservative treatment (P < 0.001). Even in mild CTS, 100% improved with surgery vs. 33% with conservative management (P = 0.011). These results corroborate prior studies that compared symptoms to CTS grade and suggest that more objective signs associate even better. CTS grades associate with outcomes, but additional studies are required. Muscle Nerve 57: 45-48, 2018. © 2017 Wiley Periodicals, Inc.

  8. Chloroplast Protein Turnover: The Influence of Extraplastidic Processes, Including Autophagy

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    Masanori Izumi

    2018-03-01

    Full Text Available Most assimilated nutrients in the leaves of land plants are stored in chloroplasts as photosynthetic proteins, where they mediate CO2 assimilation during growth. During senescence or under suboptimal conditions, chloroplast proteins are degraded, and the amino acids released during this process are used to produce young tissues, seeds, or respiratory energy. Protein degradation machineries contribute to the quality control of chloroplasts by removing damaged proteins caused by excess energy from sunlight. Whereas previous studies revealed that chloroplasts contain several types of intraplastidic proteases that likely derived from an endosymbiosed prokaryotic ancestor of chloroplasts, recent reports have demonstrated that multiple extraplastidic pathways also contribute to chloroplast protein turnover in response to specific cues. One such pathway is autophagy, an evolutionarily conserved process that leads to the vacuolar or lysosomal degradation of cytoplasmic components in eukaryotic cells. Here, we describe and contrast the extraplastidic pathways that degrade chloroplasts. This review shows that diverse pathways participate in chloroplast turnover during sugar starvation, senescence, and oxidative stress. Elucidating the mechanisms that regulate these pathways will help decipher the relationship among the diverse pathways mediating chloroplast protein turnover.

  9. Voltammetry and In Situ Scanning Tunnelling Microscopy of De Novo Designed Heme Protein Monolayers on Au(111)-Electrode Surfaces

    DEFF Research Database (Denmark)

    Albrecht, Tim; Li, Wu; Haehnel, Wolfgang

    2006-01-01

    In the present work, we report the electrochemical characterization and in situ scanning tunnelling microscopy (STM) studies of monolayers of an artificial de novo designed heme protein MOP-C, covalently immobilized on modified Au(111) surfaces. The protein forms closely packed monolayers, which ...

  10. Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling

    Science.gov (United States)

    Klinman, Judith P

    2006-01-01

    Early studies of enzyme-catalysed hydride transfer reactions indicated kinetic anomalies that were initially interpreted in the context of a ‘tunnelling correction’. An alternate model for tunnelling emerged following studies of the hydrogen atom transfer catalysed by the enzyme soybean lipoxygenase. This invokes full tunnelling of all isotopes of hydrogen, with reaction barriers reflecting the heavy atom, environmental reorganization terms. Using the latter approach, we offer an integration of the aggregate data implicating hydrogen tunnelling in enzymes (i.e. deviations from Swain–Schaad relationships and the semi-classical temperature dependence of the hydrogen isotope effect). The impact of site-specific mutations of enzymes plays a critical role in our understanding of the factors that control tunnelling in enzyme reactions. PMID:16873120

  11. Characterizing the Escherichia coli O157:H7 proteome including protein associations with higher order assemblies.

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    Rembert Pieper

    Full Text Available The recent outbreak of severe infections with Shiga toxin (Stx producing Escherichia coli (STEC serotype O104:H4 highlights the need to understand horizontal gene transfer among E. coli strains, identify novel virulence factors and elucidate their pathogenesis. Quantitative shotgun proteomics can contribute to such objectives, allowing insights into the part of the genome translated into proteins and the connectivity of biochemical pathways and higher order assemblies of proteins at the subcellular level.We examined protein profiles in cell lysate fractions of STEC strain 86-24 (serotype O157:H7, following growth in cell culture or bacterial isolation from intestines of infected piglets, in the context of functionally and structurally characterized biochemical pathways of E. coli. Protein solubilization in the presence of Triton X-100, EDTA and high salt was followed by size exclusion chromatography into the approximate M(r ranges greater than 280 kDa, 280-80 kDa and 80-10 kDa. Peptide mixtures resulting from these and the insoluble fraction were analyzed by quantitative 2D-LC-nESI-MS/MS. Of the 2521 proteins identified at a 1% false discovery rate, representing 47% of all predicted E. coli O157:H7 gene products, the majority of integral membrane proteins were enriched in the high M(r fraction. Hundreds of proteins were enriched in a M(r range higher than that predicted for a monomer supporting their participation in protein complexes. The insoluble STEC fraction revealed enrichment of aggregation-prone proteins, including many that are part of large structure/function entities such as the ribosome, cytoskeleton and O-antigen biosynthesis cluster.Nearly all E. coli O157:H7 proteins encoded by prophage regions were expressed at low abundance levels or not detected. Comparative quantitative analyses of proteins from distinct cell lysate fractions allowed us to associate uncharacterized proteins with membrane attachment, potential participation in

  12. Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3

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    Ghiselli Giancarlo

    2005-01-01

    Full Text Available Abstract Background The structural maintenance of chromosome proteins SMC1 and SMC3 play an important role in the maintenance of chromosomal integrity by preventing the premature separation of the sister chromatids at the onset of anaphase. The two proteins are constitutive components of the multimeric complex cohesin and form dimers by interacting at their central globular regions. Results In order to identify proteins that by binding to SMC3 may interfere with the protein dimerization process, a human cDNA library was screened by the yeast two-hybrid system by using the hinge region of SMC3 as bait. This has lead to the identification of Hinderin, a novel five domains protein including two coiled-coil motifs and sharing a strikingly structural similarity to the SMC family of proteins. Hinderin is ubiquitously expressed in human tissues. Orthologue forms of the protein are present in other vertebrates but not in lower organisms. A mapping of the interaction sites revealed that the N- and C-terminal globular domains mediate the binding of Hinderin to SMC3. Hinderin/SMC3 complexes could be recovered by immunoprecipitation from cell lysates using an anti-SMC3 antibody, thus demonstrating that the two proteins interact in vivo. On the contrary, Hinderin did not interact with SMC1. In vivo the rate of SMC1/SMC3 interaction was decreased by the ectopic expression of Hinderin. Conclusions Hinderin is a novel binding partner of SMC3. Based on its ability to modulate SMC1/SMC3 interaction we postulate that Hinderin affects the availability of SMC3 to engage in the formation of multimeric protein complexes.

  13. Producing high-accuracy lattice models from protein atomic coordinates including side chains.

    Science.gov (United States)

    Mann, Martin; Saunders, Rhodri; Smith, Cameron; Backofen, Rolf; Deane, Charlotte M

    2012-01-01

    Lattice models are a common abstraction used in the study of protein structure, folding, and refinement. They are advantageous because the discretisation of space can make extensive protein evaluations computationally feasible. Various approaches to the protein chain lattice fitting problem have been suggested but only a single backbone-only tool is available currently. We introduce LatFit, a new tool to produce high-accuracy lattice protein models. It generates both backbone-only and backbone-side-chain models in any user defined lattice. LatFit implements a new distance RMSD-optimisation fitting procedure in addition to the known coordinate RMSD method. We tested LatFit's accuracy and speed using a large nonredundant set of high resolution proteins (SCOP database) on three commonly used lattices: 3D cubic, face-centred cubic, and knight's walk. Fitting speed compared favourably to other methods and both backbone-only and backbone-side-chain models show low deviation from the original data (~1.5 Å RMSD in the FCC lattice). To our knowledge this represents the first comprehensive study of lattice quality for on-lattice protein models including side chains while LatFit is the only available tool for such models.

  14. Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.

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    Madhusudan Venkatareddy

    Full Text Available Actin dynamics has emerged at the forefront of podocyte biology. Slit diaphragm junctional adhesion protein Nephrin is necessary for development of the podocyte morphology and transduces phosphorylation-dependent signals that regulate cytoskeletal dynamics. The present study extends our understanding of Nephrin function by showing in cultured podocytes that Nephrin activation induced actin dynamics is necessary for lamellipodia formation. Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase, Filamin and Lamellipodin, proteins important in regulation of actin and focal adhesion dynamics, as well as lamellipodia formation. Using the previously described CD16-Nephrin clustering system, Nephrin ligation or activation resulted in phosphorylation of the actin crosslinking protein Filamin in a p21 activated kinase dependent manner. Nephrin activation in cell culture results in formation of lamellipodia, a process that requires specialized actin dynamics at the leading edge of the cell along with focal adhesion turnover. In the CD16-Nephrin clustering model, Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down. We also observed decreased lamellipodia formation and cell migration in these knock down cells. These data provide evidence that Nephrin not only initiates actin polymerization but also assembles a protein complex that is necessary to regulate the architecture of the generated actin filament network and focal adhesion dynamics.

  15. Long-range protein electron transfer observed at the single-molecule level: In situ mapping of redox-gated tunneling resonance

    DEFF Research Database (Denmark)

    Chi, Qijin; Farver, O; Ulstrup, Jens

    2005-01-01

    A biomimetic long-range electron transfer (ET) system consisting of the blue copper protein azurin, a tunneling barrier bridge, and a gold single-crystal electrode was designed on the basis of molecular wiring self-assembly principles. This system is sufficiently stable and sensitive in a quasi...... on the redox potential. Maximum resonance appears around the equilibrium redox potential of azurin with an on/off current ratio of approximate to 9. Simulation analyses, based on a two-step interfacial ET model for the scanning tunneling microscopy redox process, were performed and provide quantitative...

  16. Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures

    Energy Technology Data Exchange (ETDEWEB)

    Guescini, M. [Department of Biomolecular Sciences, University of Urbino ' Carlo Bo' , 61029 Urbino (Italy); Leo, G.; Genedani, S. [Department Biomedical Sciences, University of Modena and Reggio Emilia (Italy); Carone, C. [Department Biomedical Sciences, University of Modena and Reggio Emilia (Italy); IRCCS San Camillo Lido, Venezia (Italy); Pederzoli, F. [Department Biomedical Sciences, University of Modena and Reggio Emilia (Italy); Ciruela, F. [Departament Patologia i Terapeutica Experimental, Universitat de Barcelona (Spain); Guidolin, D. [Department of Human Anatomy and Physiology, University of Padua (Italy); Stocchi, V.; Mantuano, M. [Department of Biomolecular Sciences, University of Urbino ' Carlo Bo' , 61029 Urbino (Italy); Borroto-Escuela, D.O.; Fuxe, K. [Department of Neuroscience, Karolinska Institutet, Stockholm (Sweden); Agnati, L.F., E-mail: luigiagnati@tin.it [IRCCS San Camillo Lido, Venezia (Italy)

    2012-03-10

    Recent evidence shows that cells exchange collections of signals via microvesicles (MVs) and tunneling nano-tubes (TNTs). In this paper we have investigated whether in cell cultures GPCRs can be transferred by means of MVs and TNTs from a source cell to target cells. Western blot, transmission electron microscopy and gene expression analyses demonstrate that A{sub 2A} and D{sub 2} receptors are present in released MVs. In order to further demonstrate the involvement of MVs in cell-to-cell communication we created two populations of cells (HEK293T and COS-7) transiently transfected with D{sub 2}R-CFP or A{sub 2A}R-YFP. These two types of cells were co-cultured, and FRET analysis demonstrated simultaneously positive cells to the D{sub 2}R-CFP and A{sub 2A}R-YFP. Fluorescence microscopy analysis also showed that GPCRs can move from one cell to another also by means of TNTs. Finally, recipient cells pre-incubated for 24 h with A{sub 2A}R positive MVs were treated with the adenosine A{sub 2A} receptor agonist CGS-21680. The significant increase in cAMP accumulation clearly demonstrated that A{sub 2A}Rs were functionally competent in target cells. These findings demonstrate that A{sub 2A} receptors capable of recognizing and decoding extracellular signals can be safely transferred via MVs from source to target cells.

  17. Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures

    International Nuclear Information System (INIS)

    Guescini, M.; Leo, G.; Genedani, S.; Carone, C.; Pederzoli, F.; Ciruela, F.; Guidolin, D.; Stocchi, V.; Mantuano, M.; Borroto-Escuela, D.O.; Fuxe, K.; Agnati, L.F.

    2012-01-01

    Recent evidence shows that cells exchange collections of signals via microvesicles (MVs) and tunneling nano-tubes (TNTs). In this paper we have investigated whether in cell cultures GPCRs can be transferred by means of MVs and TNTs from a source cell to target cells. Western blot, transmission electron microscopy and gene expression analyses demonstrate that A 2A and D 2 receptors are present in released MVs. In order to further demonstrate the involvement of MVs in cell-to-cell communication we created two populations of cells (HEK293T and COS-7) transiently transfected with D 2 R-CFP or A 2A R-YFP. These two types of cells were co-cultured, and FRET analysis demonstrated simultaneously positive cells to the D 2 R-CFP and A 2A R-YFP. Fluorescence microscopy analysis also showed that GPCRs can move from one cell to another also by means of TNTs. Finally, recipient cells pre-incubated for 24 h with A 2A R positive MVs were treated with the adenosine A 2A receptor agonist CGS-21680. The significant increase in cAMP accumulation clearly demonstrated that A 2A Rs were functionally competent in target cells. These findings demonstrate that A 2A receptors capable of recognizing and decoding extracellular signals can be safely transferred via MVs from source to target cells.

  18. Tunnel Formation Inferred from the I-Form Structures of the Proton-Driven Protein Secretion Motor SecDF

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    Arata Furukawa

    2017-05-01

    Full Text Available Protein secretion mediated by SecYEG translocon and SecA ATPase is enhanced by membrane-embedded SecDF by using proton motive force. A previous structural study of SecDF indicated that it comprises 12 transmembrane helices that can conduct protons and three periplasmic domains, which form at least two characterized transition states, termed the F and I forms. We report the structures of full-length SecDF in I form at 2.6- to 2.8-Å resolution. The structures revealed that SecDF in I form can generate a tunnel that penetrates the transmembrane region and functions as a proton pathway regulated by a conserved Asp residue of the transmembrane region. In one crystal structure, periplasmic cavity interacts with a molecule, potentially polyethylene glycol, which may mimic a substrate peptide. This study provides structural insights into the Sec protein translocation that allows future analyses to develop a more detailed working model for SecDF.

  19. Electron tunneling in chemistry

    International Nuclear Information System (INIS)

    Zamaraev, K.I.; Khajrutdinov, R.F.; Zhdanov, V.P.; Molin, Yu.N.

    1985-01-01

    Results of experimental and theoretical investigations are outlined systematically on electron tunnelling in chemical reactions. Mechanism of electron transport to great distances is shown to be characteristic to chemical compounds of a wide range. The function of tunnel reactions is discussed for various fields of chemistry, including radiation chemistry, electrochemistry, chemistry of solids, chemistry of surface and catalysis

  20. Unstable Semiclassical Trajectories in Tunneling

    CERN Document Server

    Levkov, D G; Sibiryakov, S M

    2007-01-01

    Some tunneling phenomena are described, in the semiclassical approximation, by unstable complex trajectories. We develop a systematic procedure to stabilize the trajectories and to calculate the tunneling probability, including both the suppression exponent and prefactor. We find that the instability of tunneling solutions modifies the power-law dependence of the prefactor on h as compared to the case of stable solutions.

  1. Physical model for recognition tunneling

    International Nuclear Information System (INIS)

    Krstić, Predrag; Ashcroft, Brian; Lindsay, Stuart

    2015-01-01

    Recognition tunneling (RT) identifies target molecules trapped between tunneling electrodes functionalized with recognition molecules that serve as specific chemical linkages between the metal electrodes and the trapped target molecule. Possible applications include single molecule DNA and protein sequencing. This paper addresses several fundamental aspects of RT by multiscale theory, applying both all-atom and coarse-grained DNA models: (1) we show that the magnitude of the observed currents are consistent with the results of non-equilibrium Green’s function calculations carried out on a solvated all-atom model. (2) Brownian fluctuations in hydrogen bond-lengths lead to current spikes that are similar to what is observed experimentally. (3) The frequency characteristics of these fluctuations can be used to identify the trapped molecules with a machine-learning algorithm, giving a theoretical underpinning to this new method of identifying single molecule signals. (paper)

  2. An approach to including protein quality when assessing the net contribution of livestock to human food supply.

    Science.gov (United States)

    Ertl, P; Knaus, W; Zollitsch, W

    2016-11-01

    The production of protein from animal sources is often criticized because of the low efficiency of converting plant protein from feeds into protein in the animal products. However, this critique does not consider the fact that large portions of the plant-based proteins fed to animals may be human-inedible and that the quality of animal proteins is usually superior as compared with plant proteins. The aim of the present study was therefore to assess changes in protein quality in the course of the transformation of potentially human-edible plant proteins into animal products via livestock production; data from 30 Austrian dairy farms were used as a case study. A second aim was to develop an approach for combining these changes with quantitative aspects (e.g. with the human-edible feed conversion efficiency (heFCE), defined as kilogram protein in the animal product divided by kilogram potentially human-edible protein in the feeds). Protein quality of potentially human-edible inputs and outputs was assessed using the protein digestibility-corrected amino acid score and the digestible indispensable amino acid score, two methods proposed by the Food and Agriculture Organization of the United Nations to describe the nutritional value of proteins for humans. Depending on the method used, protein scores were between 1.40 and 1.87 times higher for the animal products than for the potentially human-edible plant protein input on a barn-gate level (=protein quality ratio (PQR)). Combining the PQR of 1.87 with the heFCE for the same farms resulted in heFCE×PQR of 2.15. Thus, considering both quantity and quality, the value of the proteins in the animal products for human consumption (in this case in milk and beef) is 2.15 times higher than that of proteins in the potentially human-edible plant protein inputs. The results of this study emphasize the necessity of including protein quality changes resulting from the transformation of plant proteins to animal proteins when

  3. Health effects of an increased protein intake on kidney function and colorectal cancer risk factors, including the role of animal and plant protein sources – the PREVIEW project

    DEFF Research Database (Denmark)

    Møller, Grith

    data from three European population studies; NQplus, Lifelines and the Young Finns Study (paper I) as well as the large international RCT (paper II and paper III). In paper I, the aim of the study was to develop a protein diet score, based on both dietary protein quantity and source i.e. plant...... intake, including the role of animal and plant protein in pre-diabetic, overweight or obese individuals on health outcomes: markers of kidney function and putative risk factors for colorectal cancer as well as insulin sensitivity and kidney function in healthy individuals. The thesis is based on PREVIEW...... or animal protein. The score was used to investigate the relation to T2D-related adverse metabolic health events. A total of 76,777 healthy individuals were included in the analysis. We found that a higher total protein diet score (higher intake of total protein and plant to animal protein ratio...

  4. Quantum dissipation, scattering and tunneling

    International Nuclear Information System (INIS)

    Eleuterio, S.M.; Vilela Mendes, R.

    1984-01-01

    A quantization technique for dissipative systems is used to discuss one dimensional problems including tunneling with dissipation, capture in dissipative potential wells and quantum coherence. (orig.)

  5. Air filter devices including nonwoven meshes of electrospun recombinant spider silk proteins.

    Science.gov (United States)

    Lang, Gregor; Jokisch, Stephan; Scheibel, Thomas

    2013-05-08

    Based on the natural sequence of Araneus diadematus Fibroin 4 (ADF4), the recombinant spider silk protein eADF4(C16) has been engineered. This highly repetitive protein has a molecular weight of 48kDa and is soluble in different solvents (hexafluoroisopropanol (HFIP), formic acid and aqueous buffers). eADF4(C16) provides a high potential for various technical applications when processed into morphologies such as films, capsules, particles, hydrogels, coatings, fibers and nonwoven meshes. Due to their chemical stability and controlled morphology, the latter can be used to improve filter materials. In this protocol, we present a procedure to enhance the efficiency of different air filter devices, by deposition of nonwoven meshes of electrospun recombinant spider silk proteins. Electrospinning of eADF4(C16) dissolved in HFIP results in smooth fibers. Variation of the protein concentration (5-25% w/v) results in different fiber diameters (80-1,100 nm) and thus pore sizes of the nonwoven mesh. Post-treatment of eADF4(C16) electrospun from HFIP is necessary since the protein displays a predominantly α-helical secondary structure in freshly spun fibers, and therefore the fibers are water soluble. Subsequent treatment with ethanol vapor induces formation of water resistant, stable β-sheet structures, preserving the morphology of the silk fibers and meshes. Secondary structure analysis was performed using Fourier transform infrared spectroscopy (FTIR) and subsequent Fourier self-deconvolution (FSD). The primary goal was to improve the filter efficiency of existing filter substrates by adding silk nonwoven layers on top. To evaluate the influence of electrospinning duration and thus nonwoven layer thickness on the filter efficiency, we performed air permeability tests in combination with particle deposition measurements. The experiments were carried out according to standard protocols.

  6. Air Filter Devices Including Nonwoven Meshes of Electrospun Recombinant Spider Silk Proteins

    Science.gov (United States)

    Lang, Gregor; Jokisch, Stephan; Scheibel, Thomas

    2013-01-01

    Based on the natural sequence of Araneus diadematus Fibroin 4 (ADF4), the recombinant spider silk protein eADF4(C16) has been engineered. This highly repetitive protein has a molecular weight of 48kDa and is soluble in different solvents (hexafluoroisopropanol (HFIP), formic acid and aqueous buffers). eADF4(C16) provides a high potential for various technical applications when processed into morphologies such as films, capsules, particles, hydrogels, coatings, fibers and nonwoven meshes. Due to their chemical stability and controlled morphology, the latter can be used to improve filter materials. In this protocol, we present a procedure to enhance the efficiency of different air filter devices, by deposition of nonwoven meshes of electrospun recombinant spider silk proteins. Electrospinning of eADF4(C16) dissolved in HFIP results in smooth fibers. Variation of the protein concentration (5-25% w/v) results in different fiber diameters (80-1,100 nm) and thus pore sizes of the nonwoven mesh. Post-treatment of eADF4(C16) electrospun from HFIP is necessary since the protein displays a predominantly α-helical secondary structure in freshly spun fibers, and therefore the fibers are water soluble. Subsequent treatment with ethanol vapor induces formation of water resistant, stable β-sheet structures, preserving the morphology of the silk fibers and meshes. Secondary structure analysis was performed using Fourier transform infrared spectroscopy (FTIR) and subsequent Fourier self-deconvolution (FSD). The primary goal was to improve the filter efficiency of existing filter substrates by adding silk nonwoven layers on top. To evaluate the influence of electrospinning duration and thus nonwoven layer thickness on the filter efficiency, we performed air permeability tests in combination with particle deposition measurements. The experiments were carried out according to standard protocols. PMID:23685883

  7. A protein diet score, including plant and animal protein, investigating the association with HbA1c and eGFR - the PREVIEW project

    DEFF Research Database (Denmark)

    Møller, Grith; Sluik, Diewertje; Ritz, Christian

    2017-01-01

    Higher-protein diets have been advocated for body-weight regulation for the past few decades. However, the potential health risks of these diets are still uncertain. We aimed to develop a protein score based on the quantity and source of protein, and to examine the association of the score...... with glycated haemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR). Analyses were based on three population studies included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World): NQplus, Lifelines, and the Young Finns...... Study. Cross-sectional data from food-frequency questionnaires (n = 76,777 subjects) were used to develop a protein score consisting of two components: 1) percentage of energy from total protein, and 2) plant to animal protein ratio. An inverse association between protein score and HbA1c (slope -0...

  8. Novel drugs and vaccines based on the structure and function of HIV pathogenic proteins including Nef.

    Science.gov (United States)

    Azad, Ahmed A

    2005-11-01

    Evidence is presented to suggest that HIV-1 accessory protein Nef could be involved in AIDS pathogenesis. When present in extracellular medium, Nef causes the death of a wide variety of cells in vitro and may therefore be responsible for the depletion of bystander cells in lymphoid tissues during HIV infection. When present inside the cell, Nef could prevent the death of infected cells and thereby contribute to increased viral load. Intracellular Nef does this by preventing apoptosis of infected cells by either inhibiting proteins involved in apoptosis or preventing the infected cells from being recognized by CTLs. Neutralization of extracellular Nef could prevent the death of uninfected immune cells and thereby the destruction of the immune system. Neutralization of intracellular Nef could hasten the death of infected cells and help reduce the viral load. Nef is therefore a very important molecular target for developing therapeutics that slow progression to AIDS. The N-terminal region of Nef and the naturally occurring bee venom mellitin have very similar primary and tertiary structures, and they both act by destroying membranes. Chemical analogs of a mellitin inhibitor prevent Nef-mediated cell death and inhibit the interaction of Nef with cellular proteins involved in apoptosis. Naturally occurring bee propolis also contains substances that prevent Nef-mediated cell lysis and increases proliferation of CD4 cells in HIV-infected cultures. These chemical compounds and natural products are water soluble and nontoxic and are therefore potentially very useful candidate drugs.

  9. Positively-charged semi-tunnel is a structural and surface characteristic of polyphosphate-binding proteins: an in-silico study.

    Directory of Open Access Journals (Sweden)

    Zheng Zachory Wei

    Full Text Available Phosphate is essential for all major life processes, especially energy metabolism and signal transduction. A linear phosphate polymer, polyphosphate (polyP, linked by high-energy phosphoanhydride bonds, can interact with various proteins, playing important roles as an energy source and regulatory factor. However, polyP-binding structures are largely unknown. Here we proposed a putative polyP binding site, a positively-charged semi-tunnel (PCST, identified by surface electrostatics analyses in polyP kinases (PPKs and many other polyP-related proteins. We found that the PCSTs in varied proteins were folded in different secondary structure compositions. Molecular docking calculations revealed a significant value for binding affinity to polyP in PCST-containing proteins. Utilizing the PCST identified in the β subunit of PPK3, we predicted the potential polyP-binding domain of PPK3. The discovery of this feature facilitates future searches for polyP-binding proteins and discovery of the mechanisms for polyP-binding activities. This should greatly enhance the understanding of the many physiological functions of protein-bound polyP and the involvement of polyP and polyP-binding proteins in various human diseases.

  10. ANTIFREEZE PROTEINS IN PLANTS: AN OVERVIEW WITH AN INSIGHT INTO THE DETECTION TECHNIQUES INCLUDING NANOBIOTECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Bhavana Sharma

    2014-08-01

    Full Text Available Antifreeze proteins (AFPs are a class of polypeptides which enables various organisms to survive subzero temperatures and have been found in vertebrates, invertebrates, plants, fungi and lichens. AFPs possess the characteristic thermal hysteresis (TH and ice recrystallization inhibition (IRI properties which allow them to adsorb the surface of ice crystals and inhibit their growth and recrystallization. AFPs are also known as ice restructuring proteins due to their ability to modify ice crystal morphology which leads to formation of hexagonal shape ice crystals in the presence of AFPs and disc shape AFPs in its absence. AFPs have various applications in medical, agricultural, industrial and biotechnological field. This review provides an overview of the AFPs, their TH and IRI properties and potential biotechnological applications of AFPs. Various conventional detection methods like Capillary assay and Differential Scanning Calorimetry (DSC with their advantages and disadvantages are discussed in detail along with the commonly used Splat assay and Nanoliter osmometer. Moreover, a novel, high-throughput and efficient nanobiotechnological method for AFP detection is also discussed. The method is based on colorimetric detection of freeze-labile gold nanoparticles and can provide an alternative to overcome the limitations of conventional methods by providing quick and easy way to screen AFPs in multiple systems simultaneously

  11. Recognition tunneling

    International Nuclear Information System (INIS)

    Lindsay, Stuart; He Jin; Zhang Peiming; Chang Shuai; Huang Shuo; Sankey, Otto; Hapala, Prokop; Jelinek, Pavel

    2010-01-01

    Single molecules in a tunnel junction can now be interrogated reliably using chemically functionalized electrodes. Monitoring stochastic bonding fluctuations between a ligand bound to one electrode and its target bound to a second electrode ('tethered molecule-pair' configuration) gives insight into the nature of the intermolecular bonding at a single molecule-pair level, and defines the requirements for reproducible tunneling data. Simulations show that there is an instability in the tunnel gap at large currents, and this results in a multiplicity of contacts with a corresponding spread in the measured currents. At small currents (i.e. large gaps) the gap is stable, and functionalizing a pair of electrodes with recognition reagents (the 'free-analyte' configuration) can generate a distinct tunneling signal when an analyte molecule is trapped in the gap. This opens up a new interface between chemistry and electronics with immediate implications for rapid sequencing of single DNA molecules. (topical review)

  12. Recognition tunneling

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, Stuart; He Jin; Zhang Peiming; Chang Shuai; Huang Shuo [Biodesign Institute, Arizona State University, Tempe, AZ 85287 (United States); Sankey, Otto [Department of Physics, Arizona State University, Tempe, AZ 85287 (United States); Hapala, Prokop; Jelinek, Pavel [Institute of Physics, Academy of Sciences of the Czech Republic, Cukrovarnicka 10, 1862 53, Prague (Czech Republic)

    2010-07-02

    Single molecules in a tunnel junction can now be interrogated reliably using chemically functionalized electrodes. Monitoring stochastic bonding fluctuations between a ligand bound to one electrode and its target bound to a second electrode ('tethered molecule-pair' configuration) gives insight into the nature of the intermolecular bonding at a single molecule-pair level, and defines the requirements for reproducible tunneling data. Simulations show that there is an instability in the tunnel gap at large currents, and this results in a multiplicity of contacts with a corresponding spread in the measured currents. At small currents (i.e. large gaps) the gap is stable, and functionalizing a pair of electrodes with recognition reagents (the 'free-analyte' configuration) can generate a distinct tunneling signal when an analyte molecule is trapped in the gap. This opens up a new interface between chemistry and electronics with immediate implications for rapid sequencing of single DNA molecules. (topical review)

  13. Native SDS-PAGE: high resolution electrophoretic separation of proteins with retention of native properties including bound metal ions.

    Science.gov (United States)

    Nowakowski, Andrew B; Wobig, William J; Petering, David H

    2014-05-01

    Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is commonly used to obtain high resolution separation of complex mixtures of proteins. The method initially denatures the proteins that will undergo electrophoresis. Although covalent structural features of resolved proteins can be determined with SDS-PAGE, functional properties are destroyed, including the presence of non-covalently bound metal ions. To address this shortcoming, blue-native (BN)-PAGE has been introduced. This method retains functional properties but at the cost of protein resolving power. To address the need for a high resolution PAGE method that results in the separation of native proteins, experiments tested the impact of changing the conditions of SDS-PAGE on the quality of protein separation and retention of functional properties. Removal of SDS and EDTA from the sample buffer together with omission of a heating step had no effect on the results of PAGE. Reduction of SDS in the running buffer from 0.1% to 0.0375% together with deletion of EDTA also made little impact on the quality of the electrophoretograms of fractions of pig kidney (LLC-PK1) cell proteome in comparison with that achieved with the SDS-PAGE method. The modified conditions were called native (N)SDS-PAGE. Retention of Zn(2+) bound in proteomic samples increased from 26 to 98% upon shifting from standard to modified conditions. Moreover, seven of nine model enzymes, including four Zn(2+) proteins that were subjected to NSDS-PAGE retained activity. All nine were active in BN-PAGE, whereas all underwent denaturation during SDS-PAGE. Metal retention after electrophoresis was additionally confirmed using laser ablation-inductively coupled plasma-mass spectrometry and in-gel Zn-protein staining using the fluorophore TSQ.

  14. Chemotherapy modulates intestinal immune gene expression including surfactant Protein-D and deleted in malignant brain tumors 1 in piglets

    DEFF Research Database (Denmark)

    Rathe, Mathias; Thomassen, Mads; Shen, René L.

    2016-01-01

    the BUCY and DOX piglets. Selected genes of potential biological significance with a similar change in expression across the treatments were controlled by real-time polymerase chain reaction. Key innate defense molecules, including surfactant protein-D and deleted in malignant brain tumors 1, were among...

  15. Computation of binding energies including their enthalpy and entropy components for protein-ligand complexes using support vector machines.

    Science.gov (United States)

    Koppisetty, Chaitanya A K; Frank, Martin; Kemp, Graham J L; Nyholm, Per-Georg

    2013-10-28

    Computing binding energies of protein-ligand complexes including their enthalpy and entropy terms by means of computational methods is an appealing approach for selecting initial hits and for further optimization in early stages of drug discovery. Despite the importance, computational predictions of thermodynamic components have evaded attention and reasonable solutions. In this study, support vector machines are used for developing scoring functions to compute binding energies and their enthalpy and entropy components of protein-ligand complexes. The binding energies computed from our newly derived scoring functions have better Pearson's correlation coefficients with experimental data than previously reported scoring functions in benchmarks for protein-ligand complexes from the PDBBind database. The protein-ligand complexes with binding energies dominated by enthalpy or entropy term could be qualitatively classified by the newly derived scoring functions with high accuracy. Furthermore, it is found that the inclusion of comprehensive descriptors based on ligand properties in the scoring functions improved the accuracy of classification as well as the prediction of binding energies including their thermodynamic components. The prediction of binding energies including the enthalpy and entropy components using the support vector machine based scoring functions should be of value in the drug discovery process.

  16. Engineering a de Novo Transport Tunnel

    Czech Academy of Sciences Publication Activity Database

    Březovský, J.; Babková, P.; Degtjarik, O.; Fořtová, A.; Gora, A.; Iermak, I.; Řezáčová, Pavlína; Dvořák, P.; Kutá Smatanová, I.; Prokop, Z.; Chaloupková, R.; Damborský, J.

    2016-01-01

    Roč. 6, č. 11 (2016), s. 7597-7610 ISSN 2155-5435 Institutional support: RVO:61388963 Keywords : transport tunnel * protein engineering * protein design * activity * specificity Subject RIV: CE - Biochemistry Impact factor: 10.614, year: 2016

  17. Engineering a de Novo Transport Tunnel

    Czech Academy of Sciences Publication Activity Database

    Březovský, J.; Babková, P.; Degtjarik, Oksana; Fořtová, A.; Gora, A.; Iermak, Iuliia; Řezáčová, Pavlína; Dvořák, P.; Kutá Smatanová, Ivana; Prokop, Z.; Chaloupková, R.; Damborský, J.

    2016-01-01

    Roč. 6, č. 11 (2016), s. 7597-7610 ISSN 2155-5435 Institutional support: RVO:61388971 ; RVO:68378050 Keywords : transport tunnel * protein engineering * protein design Subject RIV: EE - Microbiology, Virology Impact factor: 10.614, year: 2016

  18. Excavating a transfer tunnel

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    The transfer tunnel being dug here will take the 450 GeV beam from the SPS and inject it into the LHC where the beam energies will be increased to 7 TeV. In order to transfer this beam from the SPS to the LHC, two transfer tunnels are used to circulate the beams in opposite directions. When excavated, the accelerator components, including magnets, beam pipes and cryogenics will be installed and connected to both the SPS and LHC ready for operation to begin in 2008.

  19. Single Electron Tunneling

    International Nuclear Information System (INIS)

    Ruggiero, Steven T.

    2005-01-01

    Financial support for this project has led to advances in the science of single-electron phenomena. Our group reported the first observation of the so-called ''Coulomb Staircase'', which was produced by tunneling into ultra-small metal particles. This work showed well-defined tunneling voltage steps of width e/C and height e/RC, demonstrating tunneling quantized on the single-electron level. This work was published in a now well-cited Physical Review Letter. Single-electron physics is now a major sub-field of condensed-matter physics, and fundamental work in the area continues to be conducted by tunneling in ultra-small metal particles. In addition, there are now single-electron transistors that add a controlling gate to modulate the charge on ultra-small photolithographically defined capacitive elements. Single-electron transistors are now at the heart of at least one experimental quantum-computer element, and single-electron transistor pumps may soon be used to define fundamental quantities such as the farad (capacitance) and the ampere (current). Novel computer technology based on single-electron quantum dots is also being developed. In related work, our group played the leading role in the explanation of experimental results observed during the initial phases of tunneling experiments with the high-temperature superconductors. When so-called ''multiple-gap'' tunneling was reported, the phenomenon was correctly identified by our group as single-electron tunneling in small grains in the material. The main focus throughout this project has been to explore single electron phenomena both in traditional tunneling formats of the type metal/insulator/particles/insulator/metal and using scanning tunneling microscopy to probe few-particle systems. This has been done under varying conditions of temperature, applied magnetic field, and with different materials systems. These have included metals, semi-metals, and superconductors. Amongst a number of results, we have

  20. Carpal Tunnel Syndrome

    Science.gov (United States)

    ... a passing cramp? It could be carpal tunnel syndrome. The carpal tunnel is a narrow passageway of ... three times more likely to have carpal tunnel syndrome than men. Early diagnosis and treatment are important ...

  1. Tunneling Flight Time, Chemistry, and Special Relativity.

    Science.gov (United States)

    Petersen, Jakob; Pollak, Eli

    2017-09-07

    Attosecond ionization experiments have not resolved the question "What is the tunneling time?". Different definitions of tunneling time lead to different results. Second, a zero tunneling time for a material particle suggests that the nonrelativistic theory includes speeds greater than the speed of light. Chemical reactions, occurring via tunneling, should then not be considered in terms of a nonrelativistic quantum theory calling into question quantum dynamics computations on tunneling reactions. To answer these questions, we define a new experimentally measurable paradigm, the tunneling flight time, and show that it vanishes for scattering through an Eckart or a square barrier, irrespective of barrier length or height, generalizing the Hartman effect. We explain why this result does not lead to experimental measurement of speeds greater than the speed of light. We show that this tunneling is an incoherent process by comparing a classical Wigner theory with exact quantum mechanical computations.

  2. Final technical brief / DOE grant DE-FG03-96 ER 62219. Computational study of electron tunneling in proteins

    Energy Technology Data Exchange (ETDEWEB)

    Jeffrey J. Regan

    1999-03-03

    Electron transfer (ET) processes in proteins are characterized by the motion of a single electron between centers of localization (such as the chlorophyll dimer in photosynthetic reaction centers). An electronic donor state D is created by the injection of an electron or by photo-excitation, after which the system makes a radiationless transition to an acceptor state A., resulting in the effective transfer of an electron over several angstroms. The experimental and theoretical understanding of the rate of this process has been the focus of much attention in physics, chemistry and biology.

  3. Carpal tunnel release

    DEFF Research Database (Denmark)

    Larsen, Morten Bo; Sørensen, A I; Crone, K L

    2013-01-01

    A single-blind, randomized, controlled trial was done to compare the results of carpal tunnel release using classic incision, short incision, or endoscopic technique. In total, 90 consecutive cases were included. Follow-up was 24 weeks. We found a significantly shorter sick leave in the endoscopi...... incision could be found. There were no serious complications in either group. The results indicate that the endoscopic procedure is safe and has the benefit of faster rehabilitation and return to work....

  4. Computed tomography value and tunnel enlargement of round and rounded rectangular femoral bone tunnel for anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Takata, Yasushi; Nakase, Junsuke; Numata, Hitoaki; Oshima, Takeshi; Tsuchiya, Hiroyuki

    2016-11-01

    We developed a novel technique for anatomical single-bundle anterior cruciate ligament (ACL) reconstruction: creation of a rounded rectangular femoral bone tunnel. The purpose of this study was to compare the computed tomography (CT) value and tunnel enlargement ratio of the femoral bone tunnel with those of round tunnel ACL reconstruction. We included 39 knees that underwent round tunnel ACL reconstruction and 42 that underwent rounded rectangular ACL reconstruction. To evaluate the CT value, we compared the CT images approximately 1 week after surgery. Making a parallel slice toward the opening of bone tunnels to a depth of 3 mm, we evaluated the CT value of eight directions in the bone tunnel wall. To evaluate tunnel enlargement, we compared CT images approximately 1 week after surgery with images taken 3 months after surgery. Using a parallel slice toward the opening of the bone tunnel, we measured the bone tunnel area and calculated the tunnel enlargement ratio. The level of significance was P value was significantly increased for the rounded rectangular tunnel in comparison with the round tunnel in almost all directions (P < 0.05). The rounded rectangular tunnel area enlargement ratio was significantly lower (round, 110 ± 38 %; rounded rectangular, 73 ± 37 %; P = 0.001). The rounded rectangular tunnel could have a compression effect on the cancellous bone and reduce enlargement of the bone tunnel.

  5. Quantum tunneling and field electron emission theories

    CERN Document Server

    Liang, Shi-Dong

    2013-01-01

    Quantum tunneling is an essential issue in quantum physics. Especially, the rapid development of nanotechnology in recent years promises a lot of applications in condensed matter physics, surface science and nanodevices, which are growing interests in fundamental issues, computational techniques and potential applications of quantum tunneling. The book involves two relevant topics. One is quantum tunneling theory in condensed matter physics, including the basic concepts and methods, especially for recent developments in mesoscopic physics and computational formulation. The second part is the f

  6. Do we see what we should see? Describing non-covalent interactions in protein structures including precision

    Directory of Open Access Journals (Sweden)

    Manickam Gurusaran

    2014-01-01

    Full Text Available The power of X-ray crystal structure analysis as a technique is to `see where the atoms are'. The results are extensively used by a wide variety of research communities. However, this `seeing where the atoms are' can give a false sense of security unless the precision of the placement of the atoms has been taken into account. Indeed, the presentation of bond distances and angles to a false precision (i.e. to too many decimal places is commonplace. This article has three themes. Firstly, a basis for a proper representation of protein crystal structure results is detailed and demonstrated with respect to analyses of Protein Data Bank entries. The basis for establishing the precision of placement of each atom in a protein crystal structure is non-trivial. Secondly, a knowledge base harnessing such a descriptor of precision is presented. It is applied here to the case of salt bridges, i.e. ion pairs, in protein structures; this is the most fundamental place to start with such structure-precision representations since salt bridges are one of the tenets of protein structure stability. Ion pairs also play a central role in protein oligomerization, molecular recognition of ligands and substrates, allosteric regulation, domain motion and α-helix capping. A new knowledge base, SBPS (Salt Bridges in Protein Structures, takes these structural precisions into account and is the first of its kind. The third theme of the article is to indicate natural extensions of the need for such a description of precision, such as those involving metalloproteins and the determination of the protonation states of ionizable amino acids. Overall, it is also noted that this work and these examples are also relevant to protein three-dimensional structure molecular graphics software.

  7. Submucosal tunneling techniques: current perspectives

    Directory of Open Access Journals (Sweden)

    Kobara H

    2014-04-01

    Full Text Available Hideki Kobara,1 Hirohito Mori,1 Kazi Rafiq,2 Shintaro Fujihara,1 Noriko Nishiyama,1 Maki Ayaki,1 Tatsuo Yachida,1 Tae Matsunaga,1 Johji Tani,1 Hisaaki Miyoshi,1 Hirohito Yoneyama,1 Asahiro Morishita,1 Makoto Oryu,1 Hisakazu Iwama,3 Tsutomu Masaki1 1Department of Gastroenterology and Neurology, 2Department of Pharmacology, 3Life Science Research Center, Faculty of Medicine, Kagawa University, Miki-cho, Kita-Gun, Kagawa, Japan Abstract: Advances in endoscopic submucosal dissection include a submucosal tunneling technique, involving the introduction of tunnels into the submucosa. These tunnels permit safer offset entry into the peritoneal cavity for natural orifice transluminal endoscopic surgery. Technical advantages include the visual identification of the layers of the gut, blood vessels, and subepithelial tumors. The creation of a mucosal flap that minimizes air and fluid leakage into the extraluminal cavity can enhance the safety and efficacy of surgery. This submucosal tunneling technique was adapted for esophageal myotomy, culminating in its application to patients with achalasia. This method, known as per oral endoscopic myotomy, has opened up the new discipline of submucosal endoscopic surgery. Other clinical applications of the submucosal tunneling technique include its use in the removal of gastrointestinal subepithelial tumors and endomicroscopy for the diagnosis of functional and motility disorders. This review suggests that the submucosal tunneling technique, involving a mucosal safety flap, can have potential values for future endoscopic developments. Keywords: submucosal endoscopy, submucosal tunneling method, natural orifice transluminal endoscopic surgery, peroral endoscopic myotomy, gastrointestinal subepithelial tumor, functional and motility disorders

  8. Resonant tunneling of electrons in quantum wires

    International Nuclear Information System (INIS)

    Krive, I.V.; Shekhter, R.I.; Jonson, M.; Krive, I.V.

    2010-01-01

    We considered resonant electron tunneling in various nanostructures including single wall carbon nanotubes, molecular transistors and quantum wires formed in two-dimensional electron gas. The review starts with a textbook description of resonant tunneling of noninteracting electrons through a double-barrier structure. The effects of electron-electron interaction in sequential and resonant electron tunneling are studied by using Luttinger liquid model of electron transport in quantum wires. The experimental aspects of the problem (fabrication of quantum wires and transport measurements) are also considered. The influence of vibrational and electromechanical effects on resonant electron tunneling in molecular transistors is discussed.

  9. Accumulation of small heat shock proteins, including mitochondrial HSP22, induced by oxidative stress and adaptive response in tomato cells

    International Nuclear Information System (INIS)

    Banzet, N.; Richaud, C.; Deveaux, Y.; Kazmaier, M.; Gagnon, J.; Triantaphylides, C.

    1998-01-01

    Changes in gene expression, by application of H2O2, O2.- generating agents (methyl viologen, digitonin) and gamma irradiation to tomato suspension cultures, were investigated and compared to the well-described heat shock response. Two-dimensional gel protein mapping analyses gave the first indication that at least small heat shock proteins (smHSP) accumulated in response to application of H2O2 and gamma irradiation, but not to O2.- generating agents. While some proteins seemed to be induced specifically by each treatment, only part of the heat shock response was observed. On the basis of Northern hybridization experiments performed with four heterologous cDNA, corresponding to classes I-IV of pea smHSP, it could be concluded that significant amounts of class I and II smHSP mRNA are induced by H2O2 and by irradiation. Taken together, these results demonstrate that in plants some HSP genes are inducible by oxidative stresses, as in micro-organisms and other eukaryotic cells. HSP22, the main stress protein that accumulates following H2O2 action or gamma irradiation, was also purified. Sequence homology of amino terminal and internal sequences, and immunoreactivity with Chenopodium rubrum mitochondrial smHSP antibody, indicated that the protein belongs to the recently discovered class of plant mitochondrial smHSP. Heat shock or a mild H2O2 pretreatment was also shown to lead to plant cell protection against oxidative injury. Therefore, the synthesis of these stress proteins can be considered as an adaptive mechanism in which mitochondrial protection could be essential

  10. Hypersonic Tunnel Facility (HTF)

    Data.gov (United States)

    Federal Laboratory Consortium — The Hypersonic Tunnel Facility (HTF) is a blow-down, non-vitiated (clean air) free-jet wind tunnel capable of testing large-scale, propulsion systems at Mach 5, 6,...

  11. Quantum theory of tunneling

    CERN Document Server

    Razavy, Mohsen

    2014-01-01

    In this revised and expanded edition, in addition to a comprehensible introduction to the theoretical foundations of quantum tunneling based on different methods of formulating and solving tunneling problems, different semiclassical approximations for multidimensional systems are presented. Particular attention is given to the tunneling of composite systems, with examples taken from molecular tunneling and also from nuclear reactions. The interesting and puzzling features of tunneling times are given extensive coverage, and the possibility of measurement of these times with quantum clocks are critically examined. In addition by considering the analogy between evanescent waves in waveguides and in quantum tunneling, the times related to electromagnetic wave propagation have been used to explain certain aspects of quantum tunneling times. These topics are treated in both non-relativistic as well as relativistic regimes. Finally, a large number of examples of tunneling in atomic, molecular, condensed matter and ...

  12. Road and Railroad Tunnels

    Data.gov (United States)

    Department of Homeland Security — Tunnels in the United States According to the HSIP Tiger Team Report, a tunnel is defined as a linear underground passageway open at both ends. This dataset is based...

  13. Transonic Dynamics Tunnel (TDT)

    Data.gov (United States)

    Federal Laboratory Consortium — The Transonic Dynamics Tunnel (TDT) is a continuous flow wind-tunnel facility capable of speeds up to Mach 1.2 at stagnation pressures up to one atmosphere. The TDT...

  14. Theory of superconducting tunneling without the tunneling Hamiltonian

    International Nuclear Information System (INIS)

    Arnold, G.B.

    1987-01-01

    When a tunneling barrier is nearly transparent, the standard tunneling (or transfer) Hamiltonian approximation fails. The author describes the theory which is necessary for calculating the tunneling current in these cases, and illustrate it by comparing theory and experiment on superconductor/insulator/superconductor (SIS) junctions have ultra-thin tunnel barriers. This theory accurately explains the subgap structure which appears in the dynamical resistance of such SIS junctions, including many observed details which no previous theory has reproduced. The expression for the current through an SIS junction with an ultrathin barrier is given by I(t) = Re{Sigma/sub n/ J/sub n/ (omega/sub o/)e/sup in omega/o/sup t/} where omega/sub o/ = 2eV/h is the Josephson frequency, V is the bias voltage, and the J/sub n/ are voltage dependent coefficients, one for each positive or negative integer, n, and n=0. The relative sign of the terms involving cos(n omega/sub o/t) and sin(n omega/sub o/t) agrees with experiment, in contrast to previous theories of Josephson tunneling

  15. Major SSC tunneling begins

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    In Texas, work has been completed on the first on the Superconducting Supercollider's major shafts. Now a boring machine has started driving the fifty-four mile elliptical accelerator tunnel. To date, contracts let for the tunnel have come in far below preliminary estimates. Five of the main fourteen foot diameter tunnel contracts have been awarded for a total of 107.4 million dollars, about forty million dollars below estimates. These contracts represent %60 percent of the total tunneling project

  16. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.

    Science.gov (United States)

    Qian, Kun; Zhong, Shao; Xie, Keming; Yu, Daozhan; Yang, Rongze; Gong, Da-Wei

    2015-09-01

    Alanine transaminase (ALT) plays an important role in gluconeogenesis by converting alanine into pyruvate for glucose production. Early studies have shown that ALT activities are upregulated in gluconeogenic conditions and may be implicated in the development of diabetes. ALT consists of two isoforms, ALT1 and ALT2, with distinctive subcellular and tissue distributions. Whether and how they are regulated are largely unknown. By using Western blotting analysis, we measured hepatic ALT isoforms at the protein level in obese and diabetic animals and in Fao hepatoma cells treated with dexamethasone and insulin. In addition, we measured glucose output in Fao cells over-expressing ALT1 and ALT2. Both ALT isoforms in the liver were increased in diabetic Goto-Kakizaki rats and during fasting. However, in ob/ob mice, only ALT2, but not ALT1, protein levels were elevated, and the increase of ALT2 was correlated with that of ALT activity. We further demonstrated that, in vitro, both ALT1 and ALT2 were induced by glucocorticoid dexamethasone, but suppressed by insulin in Fao cells. Finally, we showed that the over-expression of ALT1 and ALT2 in Fao cells directly increased glucose output. We have shown the similarity and difference in the regulation of ALT isoforms in gluconeogenic conditions at the protein level, supporting that ALT isoenzymes play an important role in glucose metabolism and may be implicated the development of insulin resistance and diabetes. Copyright © 2015 John Wiley & Sons, Ltd.

  17. MR imaging of the carpal tunnel syndrome

    International Nuclear Information System (INIS)

    Elias, D.; Lind, J.; Blair, S.; Light, T.; Wisniewski, R.; Moncado, R.

    1987-01-01

    MR is an ideal noninvasive means to image the structures forming the carpal tunnel in both normal and pathologic conditions. The carpal tunnel syndrome is a frequently encountered entity caused by compression of the median nerve as it passes through the carpal tunnel. This may result from a variety of conditions including edema from acute chronic trauma, rheumatoid tenosynovitis, degenerative joint disease or soft-tissue masses. This exhibit demonstrates the optimal MR imaging techniques to display the structures of the carpal tunnel. The normal anatomy is reviewed and variations in normal anatomy that may predispose to disease are included. Examples of the morphologic changes demonstrated in 20 patients diagnosed with carpal tunnel syndrome are displayed. The exhibit also reviews the findings in 20 postoperative cases

  18. Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15.

    Science.gov (United States)

    Hare, Nathan J; Chan, Brian; Chan, Edwina; Kaufman, Kimberley L; Britton, Warwick J; Saunders, Bernadette M

    2015-09-01

    Microparticles (MPs) are small membranous particles (100-1000 nm) released under normal steady-state conditions and are thought to provide a communication network between host cells. Previous studies demonstrated that Mycobacterium tuberculosis (M. tb) infection of macrophages increased the release of MPs, and these MPs induced a proinflammatory response from uninfected macrophages in vitro and in vivo following their transfer into uninfected mice. To determine how M. tb infection modulates the protein composition of the MPs, and if this contributes to their proinflammatory properties, we compared the proteomes of MPs derived from M. tb-infected (TBinf-MP) and uninfected human THP-1 monocytic cells. MP proteins were analyzed by GeLC-MS/MS with spectral counting revealing 68 proteins with statistically significant differential abundances. The 42 proteins increased in abundance in TBinf-MPs included proteins associated with immune function (7), lysosomal/endosomal maturation (4), vesicular formation (12), nucleosome proteins (4), and antigen processing (9). Prominent among these were the type I interferon inducible proteins, ISG15, IFIT1, IFIT2, and IFIT3. Exposure of uninfected THP-1 cells to TBinf-MPs induced increased gene expression of isg15, ifit1, ifit2, and ifit3 and the release of proinflammatory cytokines. These proteins may regulate the proinflammatory potential of the MPs and provide candidate biomarkers for M. tb infection. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2.

    Directory of Open Access Journals (Sweden)

    Veronika Mikitova

    Full Text Available BACKGROUND: Two phenylalanines (FF in an acidic tract (FFAT-motifs were originally described as having seven elements: an acidic flanking region followed by 6 residues (EFFDA-E. Such motifs are found in several lipid transfer protein (LTP families, and they interact with a protein on the cytosolic face of the ER called vesicle-associated membrane protein-associated protein (VAP. Mutation of which causes ER stress and motor neuron disease, making it important to determine which proteins bind VAP. Among other proteins that bind VAP, some contain FFAT-like motifs that are missing one or more of the seven elements. Defining how much variation is tolerated in FFAT-like motifs is a preliminary step prior to the identification of the full range of VAP interactors. RESULTS: We used a quantifiable in vivo system that measured ER targeting in a reporter yeast strain that over-expressed VAP to study the effect of substituting different elements of FFAT-like motifs in turn. By defining FFAT-like motifs more widely than before, we found them in novel proteins the functions of which had not previously been directly linked to the ER, including: two PKA anchoring proteins, AKAP220 and AKAP110; a family of plant LTPs; and the glycolipid LTP phosphatidylinositol-four-phosphate adaptor-protein-2 (FAPP-2. CONCLUSION: All of the seven essential elements of a FFAT motif tolerate variation, and weak targeting to the ER via VAP is still detected if two elements are substituted. In addition to the strong FFAT motifs already known, there are additional proteins with weaker FFAT-like motifs, which might be functionally important VAP interactors.

  20. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome

    Science.gov (United States)

    Niepel, Mario; Molloy, Kelly R.; Williams, Rosemary; Farr, Julia C.; Meinema, Anne C.; Vecchietti, Nicholas; Cristea, Ileana M.; Chait, Brian T.; Rout, Michael P.; Strambio-De-Castillia, Caterina

    2013-01-01

    The basket of the nuclear pore complex (NPC) is generally depicted as a discrete structure of eight protein filaments that protrude into the nucleoplasm and converge in a ring distal to the NPC. We show that the yeast proteins Mlp1p and Mlp2p are necessary components of the nuclear basket and that they also embed the NPC within a dynamic protein network, whose extended interactome includes the spindle organizer, silencing factors, the proteasome, and key components of messenger ribonucleoproteins (mRNPs). Ultrastructural observations indicate that the basket reduces chromatin crowding around the central transporter of the NPC and might function as a docking site for mRNP during nuclear export. In addition, we show that the Mlps contribute to NPC positioning, nuclear stability, and nuclear envelope morphology. Our results suggest that the Mlps are multifunctional proteins linking the nuclear transport channel to multiple macromolecular complexes involved in the regulation of gene expression and chromatin maintenance. PMID:24152732

  1. About tunnelling times

    International Nuclear Information System (INIS)

    Olkhovsky, V.S.; Recami, E.

    1991-08-01

    In this paper, first we critically analyse the main theoretical definitions and calculations of the sub-barrier tunnelling and reflection times. Secondly, we propose a new, physically sensible definition of such durations, on the basis of a recent general formalism (already tested for other types of quantum collisions). At last, we discuss some results regarding temporal evolution of the tunnelling processes, and in particular the ''particle'' speed during tunnelling. (author). 36 refs, 1 fig

  2. High non-anatomic tunnel position rates in ACL reconstruction failure using both transtibial and anteromedial tunnel drilling techniques.

    Science.gov (United States)

    Jaecker, Vera; Zapf, Tabea; Naendrup, Jan-Hendrik; Pfeiffer, Thomas; Kanakamedala, Ajay C; Wafaisade, Arasch; Shafizadeh, Sven

    2017-09-01

    Although it is well known from cadaveric and biomechanical studies that transtibial femoral tunnel (TT) positioning techniques are associated with non-anatomic tunnel positions, controversial data exist as so far no clinical differences could have been found, comparing transtibial with anteromedial techniques (AM). The purpose of the study was to analyze if graft failure following TT ACL reconstruction was more commonly associated with non-anatomic tunnel position in comparison with the AM technique. We hypothesized that, compared to AM techniques, non-anatomic tunnel positions correlate with TT tunnel positioning techniques. A total of 147 cases of ACL revision surgery were analyzed retrospectively. Primary ACL reconstructions were analyzed regarding the femoral tunnel drilling technique. Femoral and tibial tunnel positions were determined on CT scans using validated radiographic measurement methods. Correlation analysis was performed to determine differences between TT and AM techniques. A total of 101 cases were included, of whom 64 (63.4%) underwent the TT technique and 37 (36.6%) the AM technique for primary ACL reconstruction. Non-anatomic femoral tunnel positions were found in 77.2% and non-anatomical tibial tunnel positions in 40.1%. No correlations were found comparing tunnel positions in TT and AM techniques, revealing non-anatomic femoral tunnel positions in 79.7 and 73% and non-anatomic tibial tunnel positions in 43.7 and 35.1%, respectively (p > 0.05). Considerable rates of non-anatomic femoral and tibial tunnel positions were found in ACL revisions with both transtibial and anteromedial femoral drilling techniques. Despite the potential of placing tunnels more anatomically using an additional AM portal, this technique does not ensure anatomic tunnel positioning. Consequently, the data highlight the importance of anatomic tunnel positioning in primary ACL reconstruction, regardless of the applied drilling technique.

  3. Microsystem Aeromechanics Wind Tunnel

    Data.gov (United States)

    Federal Laboratory Consortium — The Microsystem Aeromechanics Wind Tunnel advances the study of fundamental flow physics relevant to micro air vehicle (MAV) flight and assesses vehicle performance...

  4. Superpoissonian shot noise in organic magnetic tunnel junctions

    Energy Technology Data Exchange (ETDEWEB)

    Cascales, Juan Pedro; Martinez, Isidoro; Aliev, Farkhad G., E-mail: farkhad.aliev@uam.es [Dpto. Fisica Materia Condensada C3, Instituto Nicolas Cabrera (INC), Condensed Matter Physics Institute (IFIMAC), Universidad Autonoma de Madrid, Madrid 28049 (Spain); Hong, Jhen-Yong; Lin, Minn-Tsong, E-mail: mtlin@phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei 10617, Taiwan and Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 10617, Taiwan (China); Szczepański, Tomasz; Dugaev, Vitalii K. [Department of Physics, Rzeszów University of Technology, al. Powstańców Warszawy 6, 35-959 Rzeszów (Poland); Barnaś, Józef [Faculty of Physics, Adam Mickiewicz University, ul. Umultowska 85, 61-614 Poznań, Poland and Institute of Molecular Physics, Polish Academy of Sciences, ul. Smoluchowskiego 17, 60-179 Poznań (Poland)

    2014-12-08

    Organic molecules have recently revolutionized ways to create new spintronic devices. Despite intense studies, the statistics of tunneling electrons through organic barriers remains unclear. Here, we investigate conductance and shot noise in magnetic tunnel junctions with 3,4,9,10-perylene-teracarboxylic dianhydride (PTCDA) barriers a few nm thick. For junctions in the electron tunneling regime, with magnetoresistance ratios between 10% and 40%, we observe superpoissonian shot noise. The Fano factor exceeds in 1.5–2 times the maximum values reported for magnetic tunnel junctions with inorganic barriers, indicating spin dependent bunching in tunneling. We explain our main findings in terms of a model which includes tunneling through a two level (or multilevel) system, originated from interfacial bonds of the PTCDA molecules. Our results suggest that interfaces play an important role in the control of shot noise when electrons tunnel through organic barriers.

  5. Identification and characterization of novel ERC-55 interacting proteins: evidence for the existence of several ERC-55 splicing variants; including the cytosolic ERC-55-C.

    Science.gov (United States)

    Ludvigsen, Maja; Jacobsen, Christian; Maunsbach, Arvid B; Honoré, Bent

    2009-12-01

    ERC-55, encoded from RCN2, is localized in the ER and belongs to the CREC protein family. ERC-55 is involved in various diseases and abnormal cell behavior, however, the function is not well defined and it has controversially been reported to interact with a cytosolic protein, the vitamin D receptor. We have used a number of proteomic techniques to further our functional understanding of ERC-55. By affinity purification, we observed interaction with a large variety of proteins, including those secreted and localized outside of the secretory pathway, in the cytosol and also in various organelles. We confirm the existence of several ERC-55 splicing variants including ERC-55-C localized in the cytosol in association with the cytoskeleton. Localization was verified by immunoelectron microscopy and sub-cellular fractionation. Interaction of lactoferrin, S100P, calcyclin (S100A6), peroxiredoxin-6, kininogen and lysozyme with ERC-55 was further studied in vitro by SPR experiments. Interaction of S100P requires [Ca(2+)] of approximately 10(-7) M or greater, while calcyclin interaction requires [Ca(2+)] of >10(-5) M. Interaction with peroxiredoxin-6 is independent of Ca(2+). Co-localization of lactoferrin, S100P and calcyclin with ERC-55 in the perinuclear area was analyzed by fluorescence confocal microscopy. The functional variety of the interacting proteins indicates a broad spectrum of ERC-55 activities such as immunity, redox homeostasis, cell cycle regulation and coagulation.

  6. Trajectories and traversal times in quantum tunneling

    International Nuclear Information System (INIS)

    Huang, Zhi Hong.

    1989-01-01

    The classical concepts of trajectories and traversal times applied to quantum tunneling are discussed. By using the Wentzel-Kramers-Brillouin approximation, it is found that in a forbidden region of a multidimensional space the wave function can be described by two sets of trajectories, or equivalently by two sets of wave fronts. The trajectories belonging to different sets are mutually orthogonal. An extended Huygens construction is proposed to determine these wave fronts and trajectories. In contrast to the classical results in the allowed region, these trajectories couple to each other. However, if the incident wave is normal to the turning surface, the trajectories are found to be independent and can be determined by Newton's equations of motion with inverted potential and energy. The multidimensional tunneling theory is then applied to the scanning tunneling microscope to calculate the current density distribution and to derive the expressions for the lateral resolution and the surface corrugation amplitude. The traversal time in quantum tunneling, i.e. tunneling time, is found to depend on model calculations and simulations. Computer simulation of a wave packet tunneling through a square barrier is performed. Several approaches, including the phase method, Larmor clock, and time-dependent barrier model, are investigated. For a square barrier, two characteristic times are found: One is equal to the barrier width divided by the magnitude of the imaginary velocity; the other is equal to the decay length divided by the incident velocity. It is believed that the tunneling time can only be defined operationally

  7. Scanning tunneling microscopy

    International Nuclear Information System (INIS)

    Binnig, G.; Rohrer, H.

    1983-01-01

    Based on vacuum tunneling, a novel type of microscope, the scanning tunneling microscope (STM) was developed. It has an unprecedented resolution in real space on an atomic scale. The authors review the important technical features, illustrate the power of the STM for surface topographies and discuss its potential in other areas of science and technology. (Auth.)

  8. Tunnel fire dynamics

    CERN Document Server

    Ingason, Haukur; Lönnermark, Anders

    2015-01-01

    This book covers a wide range of issues in fire safety engineering in tunnels, describes the phenomena related to tunnel fire dynamics, presents state-of-the-art research, and gives detailed solutions to these major issues. Examples for calculations are provided. The aim is to significantly improve the understanding of fire safety engineering in tunnels. Chapters on fuel and ventilation control, combustion products, gas temperatures, heat fluxes, smoke stratification, visibility, tenability, design fire curves, heat release, fire suppression and detection, CFD modeling, and scaling techniques all equip readers to create their own fire safety plans for tunnels. This book should be purchased by any engineer or public official with responsibility for tunnels. It would also be of interest to many fire protection engineers as an application of evolving technical principles of fire safety.

  9. Lack of Detection of Bt Sugarcane Cry1Ab and NptII DNA and Proteins in Sugarcane Processing Products Including Raw Sugar

    Directory of Open Access Journals (Sweden)

    Adriana Cheavegatti-Gianotto

    2018-03-01

    Full Text Available Brazil is the largest sugarcane producer and the main sugar exporter in the world. The industrial processes applied by Brazilian mills are very efficient in producing highly purified sugar and ethanol. Literature presents evidence of lack of DNA/protein in these products, regardless of the nature of sugarcane used as raw material. Recently CTNBio, the Brazilian biosafety authority, has approved the first biotechnology-derived sugarcane variety for cultivation, event CTC175-A, which expresses the Cry1Ab protein to control the sugarcane borer (Diatraea saccharalis. The event also expresses neomycin-phosphotransferase type II (NptII protein used as selectable marker during the transformation process. Because of the high purity of sugar and ethanol produced from genetically modified sugarcane, these end-products should potentially be classified as “pure substances, chemically defined,” by Brazilian Biosafety Law No. 11.105. If this classification is to be adopted, these substances are not considered as “GMO derivatives” and fall out of the scope of Law No. 11.105. In order to assess sugar composition and quality, we evaluate Cry1Ab and NptII expression in several sugarcane tissues and in several fractions from laboratory-scale processing of event CTC175-A for the presence of these heterologous proteins as well as for the presence of traces of recombinant DNA. The results of these studies show that CTC175-A presents high expression of Cry1Ab in leaves and barely detectable expression of heterologous proteins in stalks. We also evaluated the presence of ribulose-1,5-bisphosphate carboxylase/oxygenase protein and DNA in the fractions of the industrial processing of conventional Brazilian sugarcane cultivars. Results from both laboratory and industrial processing were concordant, demonstrating that DNA and protein are not detected in the clarified juice and downstream processed fractions, including ethanol and raw sugar, indicating that protein

  10. The Femarnbelt Tunnel: Regional Development Perspectives

    DEFF Research Database (Denmark)

    Matthiessen, Christian Wichmann; Lundhus, Peter

    2011-01-01

    structures (bridges/ tunnels) spanning international waterways. They concentrate traffic flows and create strong transport corridors and are the basis of new regional development regimes. In early 2011, following almost two years of extensive work on different conceptual designs for the fixed link...... it was decided that an immersed tunnel should form the basis for the continuous planning of the project, including the environmental impact studies. Completion of the link is scheduled for 2020...

  11. Does flexible tunnel drilling affect the femoral tunnel angle measurement after anterior cruciate ligament reconstruction?

    Science.gov (United States)

    Muller, Bart; Hofbauer, Marcus; Atte, Akere; van Dijk, C Niek; Fu, Freddie H

    2015-12-01

    To quantify the mean difference in femoral tunnel angle (FTA) as measured on knee radiographs between rigid and flexible tunnel drilling after anatomic anterior cruciate ligament (ACL) reconstruction. Fifty consecutive patients that underwent primary anatomic ACL reconstruction with a single femoral tunnel drilled with a flexible reamer were included in this study. The control group was comprised of 50 patients all of who underwent primary anatomic ACL reconstruction with a single femoral tunnel drilled with a rigid reamer. All femoral tunnels were drilled through a medial portal to ensure anatomic tunnel placement. The FTA was determined from post-operative anterior-to-posterior (AP) radiographs by two independent observers. A 5° difference between the two mean FTA was considered clinically significant. The average FTA, when drilled with a rigid reamer, was 42.0° ± 7.2°. Drilling with a flexible reamer resulted in a mean FTA of 44.7° ± 7.0°. The mean difference of 2.7° was not statistically significant. The intraclass correlation coefficient for inter-tester reliability was 0.895. The FTA can be reliably determined from post-operative AP radiographs and provides a useful and reproducible metric for characterizing femoral tunnel position after both rigid and flexible femoral tunnel drilling. This has implications for post-operative evaluation and preoperative treatment planning for ACL revision surgery. IV.

  12. Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination

    Science.gov (United States)

    Song, In-Kang; Lee, Jae-Jin; Cho, Jin-Hwan; Jeong, Jihye; Shin, Dong-Hae; Lee, Kong-Joo

    2016-10-01

    Reactive oxygen species (ROS) are key molecules regulating various cellular processes. However, what the cellular targets of ROS are and how their functions are regulated is unclear. This study explored the cellular proteomic changes in response to oxidative stress using H2O2 in dose- and recovery time-dependent ways. We found discernible changes in 76 proteins appearing as 103 spots on 2D-PAGE. Of these, Prxs, DJ-1, UCH-L3 and Rla0 are readily oxidized in response to mild H2O2 stress, and then degraded and active proteins are newly synthesized during recovery. In studies designed to understand the degradation process, multiple cellular modifications of redox-sensitive proteins were identified by peptide sequencing with nanoUPLC-ESI-q-TOF tandem mass spectrometry and the oxidative structural changes of Prx2 explored employing hydrogen/deuterium exchange-mass spectrometry (HDX-MS). We found that hydrogen/deuterium exchange rate increased in C-terminal region of oxidized Prx2, suggesting the exposure of this region to solvent under oxidation. We also found that Lys191 residue in this exposed C-terminal region of oxidized Prx2 is polyubiquitinated and the ubiquitinated Prx2 is readily degraded in proteasome and autophagy. These findings suggest that oxidation-induced ubiquitination and degradation can be a quality control mechanism of oxidized redox-sensitive proteins including Prxs and DJ-1.

  13. batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor.

    Science.gov (United States)

    Faucheux, M; Roignant, J-Y; Netter, S; Charollais, J; Antoniewski, C; Théodore, L

    2003-02-01

    Polycomb and trithorax group genes maintain the appropriate repressed or activated state of homeotic gene expression throughout Drosophila melanogaster development. We have previously identified the batman gene as a Polycomb group candidate since its function is necessary for the repression of Sex combs reduced. However, our present genetic analysis indicates functions of batman in both activation and repression of homeotic genes. The 127-amino-acid Batman protein is almost reduced to a BTB/POZ domain, an evolutionary conserved protein-protein interaction domain found in a large protein family. We show that this domain is involved in the interaction between Batman and the DNA binding GAGA factor encoded by the Trithorax-like gene. The GAGA factor and Batman codistribute on polytene chromosomes, coimmunoprecipitate from nuclear embryonic and larval extracts, and interact in the yeast two-hybrid assay. Batman, together with the GAGA factor, binds to MHS-70, a 70-bp fragment of the bithoraxoid Polycomb response element. This binding, like that of the GAGA factor, requires the presence of d(GA)n sequences. Together, our results suggest that batman belongs to a subset of the Polycomb/trithorax group of genes that includes Trithorax-like, whose products are involved in both activation and repression of homeotic genes.

  14. Ultrafast scanning tunneling microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Botkin, D.A. [California Univ., Berkeley, CA (United States). Dept. of Physics]|[Lawrence Berkeley Lab., CA (United States)

    1995-09-01

    I have developed an ultrafast scanning tunneling microscope (USTM) based on uniting stroboscopic methods of ultrafast optics and scanned probe microscopy to obtain nanometer spatial resolution and sub-picosecond temporal resolution. USTM increases the achievable time resolution of a STM by more than 6 orders of magnitude; this should enable exploration of mesoscopic and nanometer size systems on time scales corresponding to the period or decay of fundamental excitations. USTM consists of a photoconductive switch with subpicosecond response time in series with the tip of a STM. An optical pulse from a modelocked laser activates the switch to create a gate for the tunneling current, while a second laser pulse on the sample initiates a dynamic process which affects the tunneling current. By sending a large sequence of identical pulse pairs and measuring the average tunnel current as a function of the relative time delay between the pulses in each pair, one can map the time evolution of the surface process. USTM was used to measure the broadband response of the STM`s atomic size tunnel barrier in frequencies from tens to hundreds of GHz. The USTM signal amplitude decays linearly with the tunnel junction conductance, so the spatial resolution of the time-resolved signal is comparable to that of a conventional STM. Geometrical capacitance of the junction does not appear to play an important role in the measurement, but a capacitive effect intimately related to tunneling contributes to the measured signals and may limit the ultimate resolution of the USTM.

  15. TBM tunneling on the Yucca Mountain Project

    International Nuclear Information System (INIS)

    Morris, J.P.; Hansmire, W.H.

    1995-01-01

    The US Department of Energy's (DOE) Yucca Mountain Project (YMP) is a scientific endeavor to determine the suitability of Yucca Mountain for the first long-term, high-level nuclear waste repository in the United States. The current status of this long-term project from the construction perspective is described. A key element is construction of the Exploratory Studies Facility (ESF) Tunnel, which is being excavated with a 7.6 m (25 ft) diameter tunnel boring machine (TBM). Development of the ESF may include the excavation of over 15 km (9.3 mi) of tunnel varying in size from 3.0 to 7.6 m (10 to 25 ft). Prior to construction, extensive constructability reviews were an interactive part of the final design. The intent was to establish a constructable design that met the long-term stability requirements for radiological safety of a future repository, while maintaining flexibility for the scientific investigations and acceptable tunneling productivity

  16. Air quality assessment in Salim Slam Tunnel

    International Nuclear Information System (INIS)

    El-Fadel, M.; Hashisho, Z.; Saikaly, P.

    1999-01-01

    Full text.Vehicle emissions constitute a serious occupational environmental hazard particularly in confined spaces such as tunnels and underground parking garages. these emissions at elevated concentrations, can cause adverse health effects, which range from nausea and eye irritation to mutagenicity, carcinogenicity and even death. This paper presents an environmental air quality assessment in a tunnel located in a highly congested urban area. For this purpose, air samples were collected and analyzed for the presence of primary air pollutants, priority metals, and volatile organic carbons. Air quality modeling was conducted to simulate variations of pollutant concentrations in the tunnel under worst case scenarios including traffic congestion and no air ventilation. Field measurements and mathematical simulation results were used to develop a strategy for proper air quality management in tunnels

  17. Underwater piercing of a tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Solvik, O.

    1984-11-01

    Norwegian consultants and contractors have been confronted with the task of blasting a final penetrating passage that will open the way for the water in a reservoir to flow through the hydropower turbines. Norway has almost certainly led in this area because of its special topographical and geological conditions. The glacial activities have created a number of natural and very deep lakes forming cheap reservoirs. Piercings at depths up to about 100 m have been performed. Problems tend to increase with depth, but unsuccessful penetration can occur at any depth. Secondary effects to consider include the danger of slides when the water level is lowered, wave erosion along the lowered new shoreline, erosion at all streams and rivers flowing into the lake and groundwater erosion in the newly exposed dry shoreline. Methods of penetration can be roughly divided into two categories: penetration against the open tunnel shaft (open system); and penetration against the closed tunnel shaft (closed system). 6 figures.

  18. Single-contact tunneling thermometry

    Science.gov (United States)

    Maksymovych, Petro

    2016-02-23

    A single-contact tunneling thermometry circuit includes a tunnel junction formed between two objects. Junction temperature gradient information is determined based on a mathematical relationship between a target alternating voltage applied across the junction and the junction temperature gradient. Total voltage measured across the junction indicates the magnitude of the target alternating voltage. A thermal gradient is induced across the junction. A reference thermovoltage is measured when zero alternating voltage is applied across the junction. An increasing alternating voltage is applied while measuring a thermovoltage component and a DC rectification voltage component created by the applied alternating voltage. The target alternating voltage is reached when the thermovoltage is nullified or doubled by the DC rectification voltage depending on the sign of the reference thermovoltage. Thermoelectric current and current measurements may be utilized in place of the thermovoltage and voltage measurements. The system may be automated with a feedback loop.

  19. Spin tunneling in magnetic molecules

    Science.gov (United States)

    Kececioglu, Ersin

    In this thesis, we will focus on spin tunneling in a family of systems called magnetic molecules such as Fe8 and Mn12. This is comparatively new, in relation to other tunneling problems. Many issues are not completely solved and/or understood yet. The magnetic molecule Fe 8 has been observed to have a rich pattern of degeneracies in its magnetic spectrum. We focus on these degeneracies from several points of view. We start with the simplest anisotropy Hamiltonian to describe the Fe 8 molecule and extend our discussion to include higher order anisotropy terms. We give analytical expressions as much as we can, for the degeneracies in the semi-classical limit in both cases. We reintroduce jump instantons to the instanton formalism. Finally, we discuss the effect of the environment on the molecule. Our results, for all different models and techniques, agree well with both experimental and numerical results.

  20. Multiple Legionella pneumophila Type II secretion substrates, including a novel protein, contribute to differential infection of the amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis.

    Science.gov (United States)

    Tyson, Jessica Y; Pearce, Meghan M; Vargas, Paloma; Bagchi, Sreya; Mulhern, Brendan J; Cianciotto, Nicholas P

    2013-05-01

    Type II protein secretion (T2S) by Legionella pneumophila is required for intracellular infection of host cells, including macrophages and the amoebae Acanthamoeba castellanii and Hartmannella vermiformis. Previous proteomic analysis revealed that T2S by L. pneumophila 130b mediates the export of >25 proteins, including several that appeared to be novel. Following confirmation that they are unlike known proteins, T2S substrates NttA, NttB, and LegP were targeted for mutation. nttA mutants were impaired for intracellular multiplication in A. castellanii but not H. vermiformis or macrophages, suggesting that novel exoproteins which are specific to Legionella are especially important for infection. Because the importance of NttA was host cell dependent, we examined a panel of T2S substrate mutants that had not been tested before in more than one amoeba. As a result, RNase SrnA, acyltransferase PlaC, and metalloprotease ProA all proved to be required for optimal intracellular multiplication in H. vermiformis but not A. castellanii. Further examination of an lspF mutant lacking the T2S apparatus documented that T2S is also critical for infection of the amoeba Naegleria lovaniensis. Mutants lacking SrnA, PlaC, or ProA, but not those deficient for NttA, were defective in N. lovaniensis. Based upon analysis of a double mutant lacking PlaC and ProA, the role of ProA in H. vermiformis was connected to its ability to activate PlaC, whereas in N. lovaniensis, ProA appeared to have multiple functions. Together, these data document that the T2S system exports multiple effectors, including a novel one, which contribute in different ways to the broad host range of L. pneumophila.

  1. Wind Tunnel Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This ARDEC facility consists of subsonic, transonic, and supersonic wind tunnels to acquire aerodynamic data. Full-scale and sub-scale models of munitions are fitted...

  2. Quantum tunneling with friction

    Science.gov (United States)

    Tokieda, M.; Hagino, K.

    2017-05-01

    Using the phenomenological quantum friction models introduced by P. Caldirola [Nuovo Cimento 18, 393 (1941), 10.1007/BF02960144] and E. Kanai [Prog. Theor. Phys. 3, 440 (1948), 10.1143/ptp/3.4.440], M. D. Kostin [J. Chem. Phys. 57, 3589 (1972), 10.1063/1.1678812], and K. Albrecht [Phys. Lett. B 56, 127 (1975), 10.1016/0370-2693(75)90283-X], we study quantum tunneling of a one-dimensional potential in the presence of energy dissipation. To this end, we calculate the tunneling probability using a time-dependent wave-packet method. The friction reduces the tunneling probability. We show that the three models provide similar penetrabilities to each other, among which the Caldirola-Kanai model requires the least numerical effort. We also discuss the effect of energy dissipation on quantum tunneling in terms of barrier distributions.

  3. INCAS TRISONIC WIND TUNNEL

    Directory of Open Access Journals (Sweden)

    Florin MUNTEANU

    2009-09-01

    Full Text Available The 1.2 m x 1.2 m Trisonic Blowdown Wind Tunnel is the largest of the experimental facilities at the National Institute for Aerospace Research - I.N.C.A.S. "Elie Carafoli", Bucharest, Romania. The tunnel has been designed by the Canadian company DSMA (now AIOLOS and since its commissioning in 1978 has performed high speed aerodynamic tests for more than 120 projects of aircraft, missiles and other objects among which the twin jet fighter IAR-93, the jet trainer IAR-99, the MIG-21 Lancer, the Polish jet fighter YRYDA and others. In the last years the wind tunnel has been used mostly for experimental research in European projects such as UFAST. The high flow quality parameters and the wide range of testing capabilities ensure the competitivity of the tunnel at an international level.

  4. Water Tunnel Facility

    Data.gov (United States)

    Federal Laboratory Consortium — NETL’s High-Pressure Water Tunnel Facility in Pittsburgh, PA, re-creates the conditions found 3,000 meters beneath the ocean’s surface, allowing scientists to study...

  5. Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.

    Science.gov (United States)

    Nuss, Jonathan E; Kehn-Hall, Kylene; Benedict, Ashwini; Costantino, Julie; Ward, Michael; Peyser, Brian D; Retterer, Cary J; Tressler, Lyal E; Wanner, Laura M; McGovern, Hugh F; Zaidi, Anum; Anthony, Scott M; Kota, Krishna P; Bavari, Sina; Hakami, Ramin M

    2014-01-01

    Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV). Infection with RVFV in ruminants can cause near 100% abortion rates and recent outbreaks in naïve human populations have suggested case fatality rates of greater than thirty percent. To elucidate the roles that host proteins play during RVFV infection, proteomic analysis of RVFV virions was conducted using complementary analytical approaches, followed by functional validation studies of select identified host factors. Coupling the more traditional Gel LC/MS/MS approach (SDS PAGE followed by liquid chromatography tandem mass spectrometry) with an alternative technique that preserves protein complexes allowed the protein complement of these viral particles to be thoroughly examined. In addition to viral proteins present within the virions and virion-associated host proteins, multiple macromolecular complexes were identified. Bioinformatic analysis showed that host chaperones were among over-represented protein families associated with virions, and functional experiments using siRNA gene silencing and small molecule inhibitors identified several of these heat shock proteins, including heat shock protein 90 (HSP90), as important viral host factors. Further analysis indicated that HSP inhibition effects occur during the replication/transcription phase of the virus life cycle, leading to significant lowering of viral titers without compromising the functional capacity of released virions. Overall, these studies provide much needed further insight into interactions between RVFV and host cells, increasing our understanding of the infection process and suggesting novel strategies for anti-viral development. In particular, considering that several HSP90 inhibitors have been advancing through clinical trials for cancer treatment, these results also highlight the exciting potential of repurposing HSP90 inhibitors to treat RVF.

  6. Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.

    Directory of Open Access Journals (Sweden)

    Jonathan E Nuss

    Full Text Available Rift Valley fever is a potentially fatal disease of humans and domestic animals caused by Rift Valley fever virus (RVFV. Infection with RVFV in ruminants can cause near 100% abortion rates and recent outbreaks in naïve human populations have suggested case fatality rates of greater than thirty percent. To elucidate the roles that host proteins play during RVFV infection, proteomic analysis of RVFV virions was conducted using complementary analytical approaches, followed by functional validation studies of select identified host factors. Coupling the more traditional Gel LC/MS/MS approach (SDS PAGE followed by liquid chromatography tandem mass spectrometry with an alternative technique that preserves protein complexes allowed the protein complement of these viral particles to be thoroughly examined. In addition to viral proteins present within the virions and virion-associated host proteins, multiple macromolecular complexes were identified. Bioinformatic analysis showed that host chaperones were among over-represented protein families associated with virions, and functional experiments using siRNA gene silencing and small molecule inhibitors identified several of these heat shock proteins, including heat shock protein 90 (HSP90, as important viral host factors. Further analysis indicated that HSP inhibition effects occur during the replication/transcription phase of the virus life cycle, leading to significant lowering of viral titers without compromising the functional capacity of released virions. Overall, these studies provide much needed further insight into interactions between RVFV and host cells, increasing our understanding of the infection process and suggesting novel strategies for anti-viral development. In particular, considering that several HSP90 inhibitors have been advancing through clinical trials for cancer treatment, these results also highlight the exciting potential of repurposing HSP90 inhibitors to treat RVF.

  7. General risks for tunnelling projects: An overview

    Science.gov (United States)

    Siang, Lee Yong; Ghazali, Farid E. Mohamed; Zainun, Noor Yasmin; Ali, Roslinda

    2017-10-01

    Tunnels are indispensable when installing new infrastructure as well as when enhancing the quality of existing urban living due to their unique characteristics and potential applications. Over the past few decades, there has been a significant increase in the building of tunnels, world-wide. Tunnelling projects are complex endeavors, and risk assessment for tunnelling projects is likewise a complex process. Risk events are often interrelated. Occurrence of a technical risk usually carries cost and schedule consequences. Schedule risks typically impact cost escalation and project overhead. One must carefully consider the likelihood of a risk's occurrence and its impact in the context of a specific set of project conditions and circumstances. A project's goals, organization, and environment impacts in the context of a specific set of project conditions and circumstances. Some projects are primarily schedule driven; other projects are primarily cost or quality driven. Whether a specific risk event is perceived fundamentally as a cost risk or a schedule risk is governed by the project-specific context. Many researchers have pointed out the significance of recognition and control of the complexity, and risks of tunnelling projects. Although all general information on a project such as estimated duration, estimated cost, and stakeholders can be obtained, it is still quite difficult to accurately understand, predict and control the overall situation and development trends of the project, leading to the risks of tunnelling projects. This paper reviews all the key risks for tunnelling projects from several case studies that have been carried out by other researchers. These risks have been identified and reviewed in this paper. As a result, the current risk management plan in tunnelling projects can be enhanced by including all these reviewed risks as key information.

  8. The Beginner's Guide to Wind Tunnels with TunnelSim and TunnelSys

    Science.gov (United States)

    Benson, Thomas J.; Galica, Carol A.; Vila, Anthony J.

    2010-01-01

    The Beginner's Guide to Wind Tunnels is a Web-based, on-line textbook that explains and demonstrates the history, physics, and mathematics involved with wind tunnels and wind tunnel testing. The Web site contains several interactive computer programs to demonstrate scientific principles. TunnelSim is an interactive, educational computer program that demonstrates basic wind tunnel design and operation. TunnelSim is a Java (Sun Microsystems Inc.) applet that solves the continuity and Bernoulli equations to determine the velocity and pressure throughout a tunnel design. TunnelSys is a group of Java applications that mimic wind tunnel testing techniques. Using TunnelSys, a team of students designs, tests, and post-processes the data for a virtual, low speed, and aircraft wing.

  9. Outcome of open carpal tunnel release surgery

    International Nuclear Information System (INIS)

    Khan, A.A.; Ali, H.; Muhammad, G.; Gul, N.; Zardan, K.K.; Mushtaq, M.; Ali, S.; Bhatti, S.N.; Ali, K.; Rashid, B.; Saboor, A.

    2015-01-01

    Background: Carpel tunnel syndrome is a common compression neuropathy of the median nerve causing pain, numbness and functional dysfunction of the hand. Among the available treatments, surgical release of the nerve is the most effective and acceptable treatment option. The aim of this study was to see the outcomes of surgical release of carpel tunnel using open technique. Method: This descriptive case series was conducted at the Department of neurosurgery, Ayub Teaching Hospital Abbottabad from April 2013 to March 2014. One hundred consecutive patients with carpel tunnel syndrome were included who underwent open carpel tunnel release surgery. They were followed up at 1, 3 and 6 months. Residual pain, numbness and functional improvement of the hand were the main outcome measures. Results: Out of 100 patients, 19 were males. The age ranged from 32 to 50 years with a mean of 39.29±3.99 years. The duration of symptoms was from 5 to 24 months. In the entire series patient functional outcome and satisfaction was 82 percentage at 1 month, 94 percentage at 3 months and 97 percentage at 6 months. 18 percentage patient had residual pain at 1 month post-operative follow-up, 6percentage at 3 months and 3 percentage at 6 month follow-up. Conclusion: Open carpel tunnel release surgery is an effective procedure for compression neuropathy of the median nerve. It should be offered to all patients with moderate to severe pain and functional disability related to carpel tunnel syndrome. (author)

  10. Problems with tunneling of thin shells from black holes

    Indian Academy of Sciences (India)

    Specifically for shells tunneling out of black holes, this quantity is not invariant under canonical transformations. It can be interpreted as the transmission coefficient only in the cases in which it is invariant under canonical transformations. Although such cases include alpha decay, they do not include the tunneling of shells ...

  11. Diagnosis of Carpal Tunnel Syndrome

    Science.gov (United States)

    Keith, Michael Warren; Masear, Victoria; Chung, Kevin; Maupin, Kent; Andary, Michael; Amadio, Peter C.; Barth, Richard W.; Watters, William C.; Goldberg, Michael J.; Haralson, Robert H.; Turkelson, Charles M.; Wies, Janet L.

    2016-01-01

    This clinical practice guideline was created to improve patient care by outlining the appropriate information-gathering and decision-making processes involved in managing the diagnosis of carpal tunnel syndrome. The methods used to develop this clinical practice guideline were designed to combat bias, enhance transparency, and promote reproducibility. The guideline’s recommendations are as follows: The physician should obtain an accurate patient history. The physician should perform a physical examination of the patient that may include personal characteristics as well as performing a sensory examination, manual muscle testing of the upper extremity, and provocative and/or discriminatory tests for alternative diagnoses. The physician may obtain electrodiagnostic tests to differentiate among diagnoses. This may be done in the presence of thenar atrophy and/or persistent numbness. The physician should obtain electrodiagnostic tests when clinical and/or provocative tests are positive and surgical management is being considered. If the physician orders electrodiagnostic tests, the testing protocol should follow the American Academy of Neurology/American Association of Neuromuscular and Electrodiagnostic Medicine/American Academy of Physical Medicine and Rehabilitation guidelines for diagnosis of carpal tunnel syndrome. In addition, the physician should not routinely evaluate patients suspected of having carpal tunnel syndrome with new technology, such as magnetic resonance imaging, computed tomography, and pressure-specified sensorimotor devices in the wrist and hand. This decision was based on an additional nonsystematic literature review following the face-to-face meeting of the work group. PMID:19474448

  12. Quantum Tunneling Affects Engine Performance.

    Science.gov (United States)

    Som, Sibendu; Liu, Wei; Zhou, Dingyu D Y; Magnotti, Gina M; Sivaramakrishnan, Raghu; Longman, Douglas E; Skodje, Rex T; Davis, Michael J

    2013-06-20

    We study the role of individual reaction rates on engine performance, with an emphasis on the contribution of quantum tunneling. It is demonstrated that the effect of quantum tunneling corrections for the reaction HO2 + HO2 = H2O2 + O2 can have a noticeable impact on the performance of a high-fidelity model of a compression-ignition (e.g., diesel) engine, and that an accurate prediction of ignition delay time for the engine model requires an accurate estimation of the tunneling correction for this reaction. The three-dimensional model includes detailed descriptions of the chemistry of a surrogate for a biodiesel fuel, as well as all the features of the engine, such as the liquid fuel spray and turbulence. This study is part of a larger investigation of how the features of the dynamics and potential energy surfaces of key reactions, as well as their reaction rate uncertainties, affect engine performance, and results in these directions are also presented here.

  13. Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations.

    Science.gov (United States)

    Daigle, Richard; Guertin, Michel; Lagüe, Patrick

    2009-05-15

    The structure of oxygenated trHbN from Mycobacterium tuberculosis shows an extended heme distal hydrogen-bond network that includes Tyr33(B10), Gln58(E11), and the bound O(2). In addition, trHbN structure shows a network of hydrophobic cavities organized in two orthogonal branches. In the present work, the structure and the dynamics of oxygenated and deoxygenated trHbN in explicit water was investigated from 100 ns molecular dynamics (MD) simulations. Results show that, depending on the presence or the absence of a coordinated O(2), the Tyr33(B10) and Gln58(E11) side chains adopt two different configurations in concert with hydrogen bond network rearrangement. In addition, our data indicate that Tyr33(B10) and Gln58(E11) control the dynamics of Phe62(E15). In deoxy-trHbN, Phe62(E15) is restricted to one conformation. Upon O(2) binding, the conformation of Gln58(E11) changes and residue Phe62(E15) fluctuates between two conformations. We also conducted a systematic study of trHbN tunnels by analyzing thousands of MD snapshots with CAVER. The results show that tunnel formation is the result of the dynamic reshaping of short-lived hydrophobic cavities. The analyses indicate that the presence of these cavities is likely linked to the rigid structure of trHbN and also reveal two tunnels, EH and BE, that link the protein surface to the buried distal heme pocket and not present in the crystallographic structure. The cavities are sufficiently large to accomodate and store ligands. Tunnel dynamics in trHbN was found to be controlled by the side-chain conformation of the Tyr33(B10), Gln58(E11), and Phe62(E15) residues. Importantly, in contrast to recently published works, our extensive systematic studies show that the presence or absence of a coordinated dioxygen does not control the opening of the long tunnel but rather the opening of the EH tunnel. In addition, the data lead to new and distinctly different conclusion on the impact of the Phe62(E15) residue on trHbN tunnels

  14. Design and development of an experimental six component wind tunnel block balance using optical fibre sensors.

    CSIR Research Space (South Africa)

    De Ponte, JD

    2014-05-01

    Full Text Available In order to meet the increasingly stringent requirements for wind tunnel balances, as expressed by the wind tunnel testing community, balance design philosophy needs to be further expanded to include alternative sensor, material, design...

  15. Numerical modelling of air movement in road tunnels

    International Nuclear Information System (INIS)

    Kashef, A.; Benichou, N.; Lougheed, G. . E-mail; Debs, A.

    2003-01-01

    The objective of the Mechanical Ventilation Systems (MVS) in highway tunnels is to provide tunnel patrons with a reasonable degree of comfort during normal operation and to assist in keeping tunnels safe during emergencies. Temperature, humidity, and air velocity are among the parameters that determine the tunnel environment and indicate the level of MVS performance. To investigate the performance of the current emergency ventilation strategies for an existing tunnel system in the event of a fire, a research project is being conducted at the National Research Council of Canada. The primary objectives of the study are: a) to assess and validate the ability of in-place emergency ventilation strategies to control smoke spread and minimize the impact of smoke on tunnel users; and b) to recommend guidelines for improving ventilation operation to maximize intervention effectiveness. This will allow future development of an intelligent ventilation system based on a pre-established scenario of ventilation activated using automatic fire detection. The research study includes two phases, numerical and experimental phases. The numerical phase will use a CFD model (Solvent) to study smoke ventilation in the tunnel. The experimental phase will be used to calibrate and validate the CFD model and to establish the boundary conditions for the numerical model. Solvent was used to model a ventilation scenario using existing data. The current paper presents the initial efforts to validate the CFD model against onsite flow measurements conducted in the tunnel. The CFD model included aerodynamically significant physical features of the tunnel. (author)

  16. Particle and chemical control using tunnel flow

    Energy Technology Data Exchange (ETDEWEB)

    Chilese, Frank; Delgado, Gildardo R.; Wack, Daniel; Torczynski, John R.

    2017-09-12

    An apparatus for contaminant control, having: a first optical assembly including: a first light homogenizer tunnel with: a first end connected to an extreme ultra-violet light source, a second end in communication with a destination chamber, a first enclosed space, and, a first gas input arranged to introduce a first gas such that the first gas flows in a first direction toward the first end and in a second direction toward the second end. The apparatus alternately having: a second optical assembly including: a second light homogenizer tunnel with: a third end connected to an extreme ultra-violet light source, a fourth end in communication with a destination chamber, a second enclosed space, a diffusion barrier tube including: a fifth end facing the fourth end and a sixth end in communication with a destination chamber, and a second gas input between the second light homogenizer tunnel and the diffusion tube.

  17. Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the UL13 protein kinase and specific components of the VP16 transcriptional complex

    Directory of Open Access Journals (Sweden)

    Geller Alfred I

    2009-06-01

    Full Text Available Abstract Background Herpes Simplex Virus (HSV-1 gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression. These results raise the paradox that recombinant gene expression remains short-term even in the absence of almost all (~99% of the HSV-1 genome, HSV-1 genes, and HSV-1 gene expression. To resolve this paradox, we hypothesized that specific proteins in the HSV-1 virus particle shut off recombinant gene expression. In two earlier studies, we examined the effects on recombinant gene expression of packaging vectors using specific mutated HSV-1 proteins. We found that vectors packaged using mutated UL13 (a protein kinase, or VP16, or UL46 and/or UL47 (components of the VP16 transcriptional complex supported improved long-term expression, and vectors packaged using mutated UL46 and/or UL47 also supported improved gene transfer (numbers of cells at 4 days. These results suggested the hypothesis that specific proteins in the HSV-1 particle act by multiple pathways to reduce recombinant gene expression. To test this hypothesis, we examined combinations of mutated proteins that included both UL13 and specific components of the VP16 transcriptional complex. Results A HSV-1 vector containing a neuronal-specific promoter was packaged using specific combinations of mutated proteins, and the resulting vector stocks were tested in the rat striatum. For supporting long-term expression, the preferred combination of mutated HSV-1 proteins was mutated UL13, UL46, and UL47. Vectors packaged using this combination of mutated proteins supported a higher efficiency of gene transfer and high levels expression for 3 months, the longest time examined. Conclusion Vector particles containing this combination of mutated HSV-1 proteins improve recombinant gene expression. Implications of these results for strategies to further improve

  18. Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the UL13 protein kinase and specific components of the VP16 transcriptional complex.

    Science.gov (United States)

    Liu, Meng; Wang, Xiaodan; Geller, Alfred I

    2009-06-16

    Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression. These results raise the paradox that recombinant gene expression remains short-term even in the absence of almost all (approximately 99%) of the HSV-1 genome, HSV-1 genes, and HSV-1 gene expression. To resolve this paradox, we hypothesized that specific proteins in the HSV-1 virus particle shut off recombinant gene expression. In two earlier studies, we examined the effects on recombinant gene expression of packaging vectors using specific mutated HSV-1 proteins. We found that vectors packaged using mutated UL13 (a protein kinase), or VP16, or UL46 and/or UL47 (components of the VP16 transcriptional complex) supported improved long-term expression, and vectors packaged using mutated UL46 and/or UL47 also supported improved gene transfer (numbers of cells at 4 days). These results suggested the hypothesis that specific proteins in the HSV-1 particle act by multiple pathways to reduce recombinant gene expression. To test this hypothesis, we examined combinations of mutated proteins that included both UL13 and specific components of the VP16 transcriptional complex. A HSV-1 vector containing a neuronal-specific promoter was packaged using specific combinations of mutated proteins, and the resulting vector stocks were tested in the rat striatum. For supporting long-term expression, the preferred combination of mutated HSV-1 proteins was mutated UL13, UL46, and UL47. Vectors packaged using this combination of mutated proteins supported a higher efficiency of gene transfer and high levels expression for 3 months, the longest time examined. Vector particles containing this combination of mutated HSV-1 proteins improve recombinant gene expression. Implications of these results for strategies to further improve long-term expression are discussed

  19. An innovative band-to-band tunneling analytical model and implications in compact modeling of tunneling-based devices

    Science.gov (United States)

    De Michielis, L.; Daǧtekin, N.; Biswas, A.; Lattanzio, L.; Selmi, L.; Luisier, M.; Riel, H.; Ionescu, A. M.

    2013-09-01

    In this paper, an analytical band-to-band tunneling model is proposed, validated by means of drift-diffusion simulation and comparison with experimental data, implemented in Verilog-A, and finally proven with SPICE simulator through simulation of circuits featuring tunneling diodes. The p-n junction current calculation starts from a non-local Band-to-Band tunneling theory including the electron-phonon interaction and therefore it is particularly suited for indirect semiconductor materials such as silicon- or germanium-based interband tunneling devices.

  20. Bioinformatic prediction of G protein-coupled receptor encoding sequences from the transcriptome of the foreleg, including the Haller's organ, of the cattle tick, Rhipicephalus australis.

    Directory of Open Access Journals (Sweden)

    Sergio Munoz

    Full Text Available The cattle tick of Australia, Rhipicephalus australis, is a vector for microbial parasites that cause serious bovine diseases. The Haller's organ, located in the tick's forelegs, is crucial for host detection and mating. To facilitate the development of new technologies for better control of this agricultural pest, we aimed to sequence and annotate the transcriptome of the R. australis forelegs and associated tissues, including the Haller's organ. As G protein-coupled receptors (GPCRs are an important family of eukaryotic proteins studied as pharmaceutical targets in humans, we prioritized the identification and classification of the GPCRs expressed in the foreleg tissues. The two forelegs from adult R. australis were excised, RNA extracted, and pyrosequenced with 454 technology. Reads were assembled into unigenes and annotated by sequence similarity. Python scripts were written to find open reading frames (ORFs from each unigene. These ORFs were analyzed by different GPCR prediction approaches based on sequence alignments, support vector machines, hidden Markov models, and principal component analysis. GPCRs consistently predicted by multiple methods were further studied by phylogenetic analysis and 3D homology modeling. From 4,782 assembled unigenes, 40,907 possible ORFs were predicted. Using Blastp, Pfam, GPCRpred, TMHMM, and PCA-GPCR, a basic set of 46 GPCR candidates were compiled and a phylogenetic tree was constructed. With further screening of tertiary structures predicted by RaptorX, 6 likely GPCRs emerged and the strongest candidate was classified by PCA-GPCR to be a GABAB receptor.

  1. Epigenetics targeted protein-vorinostat nanomedicine inducing apoptosis in heterogeneous population of primary acute myeloid leukemia cells including refractory and relapsed cases.

    Science.gov (United States)

    Chandran, Parwathy; Kavalakatt, Anu; Malarvizhi, Giridharan Loghanathan; Vasanthakumari, Divya Rani Vikraman Nair; Retnakumari, Archana Payickattu; Sidharthan, Neeraj; Pavithran, Keechilat; Nair, Shantikumar; Koyakutty, Manzoor

    2014-05-01

    Aberrant epigenetics play a key role in the onset and progression of acute myeloid leukemia (AML). Herein we report in silico modelling based development of a novel, protein-vorinostat nanomedicine exhibiting selective and superior anti-leukemic activity against heterogeneous population of AML patient samples (n=9), including refractory and relapsed cases, and three representative cell lines expressing CD34(+)/CD38(-) stem cell phenotype (KG-1a), promyelocytic phenotype (HL-60) and FLT3-ITD mutation (MV4-11). Nano-vorinostat having ~100nm size exhibited enhanced cellular uptake rendering significantly lower IC50 in AML cell lines and patient samples, and induced enhanced HDAC inhibition, oxidative injury, cell cycle arrest and apoptosis compared to free vorinostat. Most importantly, nanomedicine showed exceptional single-agent activity against the clonogenic proliferative capability of bone marrow derived leukemic progenitors, while remaining non-toxic to healthy bone marrow cells. Collectively, this epigenetics targeted nanomedicine appears to be a promising therapeutic strategy against various French-American-British (FAB) classes of AML. Through the use of a protein-vorinostat agent, exceptional single-agent activity was demonstrated against the clonogenic proliferative capability of bone marrow derived leukemic progenitors, while remaining non-toxic to healthy bone marrow cells. The studied epigenetics targeted nanomedicine approach is a promising therapeutic strategy against various French-American-British classes of acute myeloid leukemia. © 2014 Elsevier Inc. All rights reserved.

  2. RITD – Wind tunnel testing

    Science.gov (United States)

    Haukka, Harri; Harri, Ari-Matti; Aleksashkin, Sergei; Koryanov, Valeri; Schmidt, Walter; Heilimo, Jyri; Finchenko, Valeri; Martynov, Maxim; Ponomarenko, Andrey; Kazakovtsev, Victor; Arruego, Ignazio

    2015-04-01

    An atmospheric re-entry and descent and landing system (EDLS) concept based on inflatable hypersonic decelerator techniques is highly promising for the Earth re-entry missions. We developed such EDLS for the Earth re-entry utilizing a concept that was originally developed for Mars. This EU-funded project is called RITD - Re-entry: Inflatable Technology Development - and it was to assess the bene¬fits of this technology when deploying small payloads from low Earth orbits to the surface of the Earth with modest costs. The principal goal was to assess and develope a preliminary EDLS design for the entire relevant range of aerodynamic regimes expected to be encountered in Earth's atmosphere during entry, descent and landing. The RITD entry and descent system utilizes an inflatable hypersonic decelerator. Development of such system requires a combination of wind tunnel tests and numerical simulations. This included wind tunnel tests both in transsonic and subsonic regimes. The principal aim of the wind tunnel tests was the determination of the RITD damping factors in the Earth atmosphere and recalculation of the results for the case of the vehicle descent in the Mars atmosphere. The RITD mock-up model used in the tests was in scale of 1:15 of the real-size vehicle as the dimensions were (midsection) diameter of 74.2 mm and length of 42 mm. For wind tunnel testing purposes the frontal part of the mock-up model body was manufactured by using a PolyJet 3D printing technology based on the light curing of liquid resin. The tail part of the mock-up model body was manufactured of M1 grade copper. The structure of the mock-up model placed th center of gravity in the same position as that of the real-size RITD. The wind tunnel test program included the defining of the damping factor at seven values of Mach numbers 0.85; 0.95; 1.10; 1.20; 1.25; 1.30 and 1.55 with the angle of attack ranging from 0 degree to 40 degrees with the step of 5 degrees. The damping characteristics of

  3. Interaction between groundwater and TBM (Tunnel Boring Machine) excavated tunnels

    OpenAIRE

    Font Capó, Jordi

    2012-01-01

    A number of problems, e.g. sudden inflows are encountered during tunneling under the piezometric level, especially when the excavation crosses high transmissivity areas. These inflows may drag materials when the tunnel crosses low competent layers, resulting in subsidence, chimney formation and collapses. Moreover, inflows can lead to a decrease in head level because of aquifer drainage. Tunnels can be drilled by a tunnel boring machine (TBM) to minimize inflows and groundwater impacts, restr...

  4. Seepage into PEP tunnel

    International Nuclear Information System (INIS)

    Weidner, H.

    1990-01-01

    The current rate of seepage into the PEP tunnel in the vicinity of IR-10 is very low compared to previous years. Adequate means of handling this low flow are in place. It is not clear whether the reduction in the flow is temporary, perhaps due to three consecutive dry years, or permanent due to drainage of a perched water table. During PEP construction a large amount of effort was expended in attempts to seal the tunnel, with no immediate effect. The efforts to ''manage'' the water flow are deemed to be successful. By covering equipment to protect it from dripping water and channeling seepage into the drainage gutters, the seepage has been reduced to a tolerable nuisance. There is no sure, safe procedure for sealing a leaky shotcreted tunnel

  5. Experience in design and construction of the Log tunnel

    Directory of Open Access Journals (Sweden)

    Jovičić Vojkan

    2017-09-01

    Full Text Available A twin highway Log tunnel is a part of a new motorway connection between Maribor and Zagreb, section Draženci-Gruškovje, which is located towards the border crossing between Slovenia and Croatia. The tunnel is currently under construction, and only the excavation works have been completed during the writing of this paper. The terrain in the area of the Log tunnel is diverse, and the route of the highway in its vicinity is characterised by deep excavations, bridges or viaducts. The Log tunnel is approximately 250 m long, partly constructed as a gallery. The geological conditions are dominated by Miocene base rock, featuring layers of well-connected clastic rocks, which are covered by diluvium clays, silts, sands and gravels of different thicknesses. Due to the short length of the tunnel, the usual separation of the motorway route to the left and the right tunnel axes was not carried out. Thus, the tunnel was constructed with an intermediate pillar and was designed as a three-lane tunnel, including the stopping lane. The construction of the tunnel was carried out using the New Austrian tunnelling method (NATM, in which the central adit was excavated first and the intermediate pillar was constructed within it. The excavation of the main tubes followed and was divided into the top heading, bench and the invert, enabling the intermediate pillar to take the load off the top heading of both tubes. The secondary lining of the tunnel is currently under construction. The experience of the tunnel construction gathered so far is presented in the paper. The main emphasis is on the construction of the intermediate pillar, which had to take the significant and asymmetrical ground load.

  6. Tunnelling from Goedel black holes

    International Nuclear Information System (INIS)

    Kerner, Ryan; Mann, R. B.

    2007-01-01

    We consider the spacetime structure of Kerr-Goedel black holes, analyzing their parameter space in detail. We apply the tunnelling method to compute their temperature and compare the results to previous calculations obtained via other methods. We claim that it is not possible to have the closed timelike curve (CTC) horizon in between the two black hole horizons and include a discussion of issues that occur when the radius of the CTC horizon is smaller than the radius of both black hole horizons

  7. LEP tunnel monorail

    CERN Multimedia

    1985-01-01

    A monorail from CERN's Large Electron Positron collider (LEP, for short). It ran around the 27km tunnel, transporting equipment and personnel. With its 27-kilometre circumference, LEP was the largest electron-positron accelerator ever built and ran from 1989 to 2000. During 11 years of research, LEP's experiments provided a detailed study of the electroweak interaction. Measurements performed at LEP also proved that there are three – and only three – generations of particles of matter. LEP was closed down on 2 November 2000 to make way for the construction of the Large Hadron Collider in the same tunnel.

  8. Breaking through the tranfer tunnel

    CERN Document Server

    Laurent Guiraud

    2001-01-01

    This image shows the tunnel boring machine breaking through the transfer tunnel into the LHC tunnel. Proton beams will be transferred from the SPS pre-accelerator to the LHC at 450 GeV through two specially constructed transfer tunnels. From left to right: LHC Project Director, Lyn Evans; CERN Director-General (at the time), Luciano Maiani, and Director for Accelerators, Kurt Hubner.

  9. Gap anisotropy and tunneling currents. [MPS3

    DEFF Research Database (Denmark)

    Lazarides, N.; Sørensen, Mads Peter

    1996-01-01

    The tunneling Hamiltonian formalism is applied to calculate the tunnelingcurrents through a small superconducting tunnel junction. The formalism isextended to nonconstant tunneling matrix elements. The electrodes of thejunction are assumed to......The tunneling Hamiltonian formalism is applied to calculate the tunnelingcurrents through a small superconducting tunnel junction. The formalism isextended to nonconstant tunneling matrix elements. The electrodes of thejunction are assumed to...

  10. Building information modelling review with potential applications in tunnel engineering of China.

    Science.gov (United States)

    Zhou, Weihong; Qin, Haiyang; Qiu, Junling; Fan, Haobo; Lai, Jinxing; Wang, Ke; Wang, Lixin

    2017-08-01

    Building information modelling (BIM) can be applied to tunnel engineering to address a number of problems, including complex structure, extensive design, long construction cycle and increased security risks. To promote the development of tunnel engineering in China, this paper combines actual cases, including the Xingu mountain tunnel and the Shigu Mountain tunnel, to systematically analyse BIM applications in tunnel engineering in China. The results indicate that BIM technology in tunnel engineering is currently mainly applied during the design stage rather than during construction and operation stages. The application of BIM technology in tunnel engineering covers many problems, such as a lack of standards, incompatibility of different software, disorganized management, complex combination with GIS (Geographic Information System), low utilization rate and poor awareness. In this study, through summary of related research results and engineering cases, suggestions are introduced and an outlook for the BIM application in tunnel engineering in China is presented, which provides guidance for design optimization, construction standards and later operation maintenance.

  11. Building information modelling review with potential applications in tunnel engineering of China

    Science.gov (United States)

    Zhou, Weihong; Qin, Haiyang; Qiu, Junling; Fan, Haobo; Lai, Jinxing; Wang, Ke; Wang, Lixin

    2017-08-01

    Building information modelling (BIM) can be applied to tunnel engineering to address a number of problems, including complex structure, extensive design, long construction cycle and increased security risks. To promote the development of tunnel engineering in China, this paper combines actual cases, including the Xingu mountain tunnel and the Shigu Mountain tunnel, to systematically analyse BIM applications in tunnel engineering in China. The results indicate that BIM technology in tunnel engineering is currently mainly applied during the design stage rather than during construction and operation stages. The application of BIM technology in tunnel engineering covers many problems, such as a lack of standards, incompatibility of different software, disorganized management, complex combination with GIS (Geographic Information System), low utilization rate and poor awareness. In this study, through summary of related research results and engineering cases, suggestions are introduced and an outlook for the BIM application in tunnel engineering in China is presented, which provides guidance for design optimization, construction standards and later operation maintenance.

  12. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein

    Directory of Open Access Journals (Sweden)

    Deussing Jan M

    2010-10-01

    Full Text Available Abstract Background The pivotal role of stress in the precipitation of psychiatric diseases such as depression is generally accepted. This study aims at the identification of genes that are directly or indirectly responding to stress. Inbred mouse strains that had been evidenced to differ in their stress response as well as in their response to antidepressant treatment were chosen for RNA profiling after stress exposure. Gene expression and regulation was determined by microarray analyses and further evaluated by bioinformatics tools including pathway and cluster analyses. Results Forced swimming as acute stressor was applied to C57BL/6J and DBA/2J mice and resulted in sets of regulated genes in the paraventricular nucleus of the hypothalamus (PVN, 4 h or 8 h after stress. Although the expression changes between the mouse strains were quite different, they unfolded in phases over time in both strains. Our search for connections between the regulated genes resulted in potential novel signalling pathways in stress. In particular, Guanine nucleotide binding protein, alpha inhibiting 2 (GNAi2 and Amyloid β (A4 precursor protein (APP were detected as stress-regulated genes, and together with other genes, seem to be integrated into stress-responsive pathways and gene networks in the PVN. Conclusions This search for stress-regulated genes in the PVN revealed its impact on interesting genes (GNAi2 and APP and a novel gene network. In particular the expression of APP in the PVN that is governing stress hormone balance, is of great interest. The reported neuroprotective role of this molecule in the CNS supports the idea that a short acute stress can elicit positive adaptational effects in the brain.

  13. Vuosaari Harbour Road Tunnel Traffic Management and Incident Detection System Design Issues

    Directory of Open Access Journals (Sweden)

    Caj Holm

    2006-11-01

    Full Text Available Helsinki is constructing in Vuosaari a new modem and effectivecargo harbour. All cargo harbour activities will be concentratedthere. The total project includes the harbour, a logisticsarea, traffic connections (road, railway and fairway and aBusiness Park. The road connection goes through the Porvarinlahtiroad tunnel. The harbour will commence operatingin 2008. This paper gives an oveTView of the tunnel design phasefunctional studies and risk analysis tunnel incident detectionsystem design issues and some specific environmental featuresof the tunnel.

  14. Tunnelling with wormhole creation

    Energy Technology Data Exchange (ETDEWEB)

    Ansoldi, S. [National Institute of Nuclear Physics (INFN) (Italy); Tanaka, T., E-mail: tanaka@yukawa.kyoto-u.ac.jp [Kyoto University, Department of Physics (Japan)

    2015-03-15

    The description of quantum tunnelling in the presence of gravity shows subtleties in some cases. We discuss wormhole production in the context of the spherically symmetric thin-shell approximation. By presenting a fully consistent treatment based on canonical quantization, we solve a controversy present in the literature.

  15. Tunnelling with wormhole creation

    OpenAIRE

    Ansoldi, Stefano; Tanaka, Takahiro

    2014-01-01

    The description of quantum tunnelling in the presence of gravity shows subtleties in some cases. Here we discuss wormhole production in the context of the spherically symmetric thin-shell approximation. By presenting a fully consistent treatment based on canonical quantization, we solve a controversy present in literature.

  16. Tunnelling Effects in Chemistry

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 2. Tunnelling Effects in Chemistry: Molecules in the Strange Quantum World. Sharmistha Karmakar Deepthi Jose Ayan Datta. General Article Volume 19 Issue 2 February 2014 pp 160-174 ...

  17. INCAS SUBSONIC WIND TUNNEL

    Directory of Open Access Journals (Sweden)

    Corneliu STOICA

    2009-09-01

    Full Text Available The INCAS Subsonic Wind Tunnel is a closed circuit, continuous, atmospheric pressure facility with a maximum speed of 110 m/s. The test section is octagonal ,of 2.5 m wide, 2.0 m high and 4 m long. The tunnel is powered by a 1200 kW, air cooled variable speed DC motor which drives a 12 blade, 3.5 m diameter fan and is equipped with a six component pyramidal type external mechanical balance with a 700 Kgf maximum lift capacity.The angle of attack range is between -45º and +45º while the yaw angle range is between -140º and +216º .The data acquisition system has been modified recently to allow the recording of all test data on a PC - type computer using LABVIEW and a PXI – type chassis containing specialized data acquisition modules.The tunnel is equipped with a variable frequency electrical supply system for powered models and a 10 bar compressed air supply for pneumatic flow control applications.In the recent years the subsonic wind tunnel has been intensively used for tests within several European projects (AVERT, CESAR and others.

  18. Tunnelling Effects in Chemistry

    Indian Academy of Sciences (India)

    IAS Admin

    GENERAL ⎜ ARTICLE. Tunnelling Effects in Chemistry. Molecules in the Strange Quantum World. Sharmistha Karmakar, Deepthi Jose and Ayan Datta. (left) Sharmistha Karmakar is doing her PhD in the group of. Ayan Datta, IACS,. Kolkata. Her research interests are modelling molecules with strong optical absorbtion and.

  19. The Channel Tunnel

    Science.gov (United States)

    2006-01-01

    The Channel Tunnel is a 50.5 km-long rail tunnel beneath the English Channel at the Straits of Dover. It connects Dover, Kent in England with Calais, northern France. The undersea section of the tunnel is unsurpassed in length in the world. A proposal for a Channel tunnel was first put forward by a French engineer in 1802. In 1881, a first attempt was made at boring a tunnel from the English side; the work was halted after 800 m. Again in 1922, English workers started boring a tunnel, and advanced 120 m before it too was halted for political reasons. The most recent attempt was begun in 1987, and the tunnel was officially opened in 1994. At completion it was estimated that the project cost around $18 billion. It has been operating at a significant loss since its opening, despite trips by over 7 million passengers per year on the Eurostar train, and over 3 million vehicles per year. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet. ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance. The

  20. Electronic thermometry in tunable tunnel junction

    Energy Technology Data Exchange (ETDEWEB)

    Maksymovych, Petro

    2016-03-15

    A tunable tunnel junction thermometry circuit includes a variable width tunnel junction between a test object and a probe. The junction width is varied and a change in thermovoltage across the junction with respect to the change in distance across the junction is determined. Also, a change in biased current with respect to a change in distance across the junction is determined. A temperature gradient across the junction is determined based on a mathematical relationship between the temperature gradient, the change in thermovoltage with respect to distance and the change in biased current with respect to distance. Thermovoltage may be measured by nullifying a thermoelectric tunneling current with an applied voltage supply level. A piezoelectric actuator may modulate the probe, and thus the junction width, to vary thermovoltage and biased current across the junction. Lock-in amplifiers measure the derivatives of the thermovoltage and biased current modulated by varying junction width.

  1. Monitoring pilot projects on bored tunnelling : The Second Heinenoord Tunnel and the Botlek Rail Tunnel

    NARCIS (Netherlands)

    Bakker, K.J.; De Boer, F.; Admiraal, J.B.M.; Van Jaarsveld, E.P.

    1999-01-01

    Two pilot projects for bored tunnelling in soft soil have been undertaken in the Netherlands. The monitoring was commissioned under the authority of the Centre for Underground Construction (COB). A description of the research related to the Second Heinenoord Tunnel and the Botlek Rail Tunnel will be

  2. Tunneling features in semiconductor nanostructures

    Science.gov (United States)

    Arseev, P. I.; Mantsevich, V. N.; Maslova, N. S.; Panov, V. I.

    2017-11-01

    The most telling scanning tunneling microscopy/spectroscopy (STM/STS) data available on the influence of nonequilibrium tunneling effects and electronic spectra reconstruction are reviewed and theoretically explained by self-consistently accounting for nonequilibrium electron distribution and the change (due to the tunneling current) in the electron density of states near the tunneling junction. The paper discusses the basic ideas of the self-consistent tunneling theory, which forms the basis for experimental research and which allows many effects observed in STM/STS experiments to be explained and new phenomena to be predicted.

  3. Measuring fire size in tunnels

    International Nuclear Information System (INIS)

    Guo, Xiaoping; Zhang, Qihui

    2013-01-01

    A new measure of fire size Q′ has been introduced in longitudinally ventilated tunnel as the ratio of flame height to the height of tunnel. The analysis in this article has shown that Q′ controls both the critical velocity and the maximum ceiling temperature in the tunnel. Before the fire flame reaches tunnel ceiling (Q′ 1.0), Fr approaches a constant value. This is also a well-known phenomenon in large tunnel fires. Tunnel ceiling temperature shows the opposite trend. Before the fire flame reaches the ceiling, it increases very slowly with the fire size. Once the flame has hit the ceiling of tunnel, temperature rises rapidly with Q′. The good agreement between the current prediction and three different sets of experimental data has demonstrated that the theory has correctly modelled the relation among the heat release rate of fire, ventilation flow and the height of tunnel. From design point of view, the theoretical maximum of critical velocity for a given tunnel can help to prevent oversized ventilation system. -- Highlights: • Fire sizing is an important safety measure in tunnel design. • New measure of fire size a function of HRR of fire, tunnel height and ventilation. • The measure can identify large and small fires. • The characteristics of different fire are consistent with observation in real fires

  4. Tunnel Diode Discriminator with Fixed Dead Time

    DEFF Research Database (Denmark)

    Diamond, J. M.

    1965-01-01

    A solid state discriminator for the range 0.4 to 10 V is described. Tunnel diodes are used for the discriminator element and in a special fixed dead time circuit. An analysis of temperature stability is presented. The regulated power supplies are described, including a special negative resistance...

  5. A Student-Built Scanning Tunneling Microscope

    Science.gov (United States)

    Ekkens, Tom

    2015-01-01

    Many introductory and nanotechnology textbooks discuss the operation of various microscopes including atomic force (AFM), scanning tunneling (STM), and scanning electron microscopes (SEM). In a nanotechnology laboratory class, students frequently utilize microscopes to obtain data without a thought about the detailed operation of the tool itself.…

  6. Preliminary study on the transport of hazardous materials through tunnels.

    Science.gov (United States)

    Bubbico, Roberto; Di Cave, Sergio; Mazzarotta, Barbara; Silvetti, Barbara

    2009-11-01

    The risk associated to road and rail transportation of some hazardous materials along two routes, one including a significant portion in tunnels, and the other following the same path, but running completely in the open, is assessed. The results show that, for rail transport, no particular risk increase or mitigation is associated to the circulation of the dangerous goods through tunnels; on the contrary, for road transport, a risk increase is generally observed in the presence of tunnels. However, for LPG, the risk curve in the open lies above that in tunnels in the high frequency-low fatality zone, according to the different evolution of the accidental scenarios in the tunnel (assuming no ventilation). The transportation of liquefied nitrogen, not hazardous in the open but potentially asphyxiating in a tunnel, gives rise to a negligible risk when performed by rail, but to a not negligible one, when performed by road. These preliminary results focused on the risk for the exposed population, suggest that it may be unnecessary to limit dangerous goods circulation through rail tunnels, while, at least for some types of dangerous goods, the circulation through road tunnels may be allowed/forbidden based on the results of a specific risk analysis.

  7. Experimental validation of multi-epitope peptides including promising MHC class I- and class II-restricted epitopes of four known Leishmania infantum proteins

    Directory of Open Access Journals (Sweden)

    Maria eAgallou

    2014-06-01

    Full Text Available Leishmaniasis is a significant worldwide health problem for which no vaccine exists. Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity against parasite. Recent trend in vaccine design has been shifted to epitope-based vaccines that are more specific, safe, and easy to produce. In the present study, four known antigenic Leishmania (L. infantum proteins, CPA, histone H1, KMP-11 and LeIF were analysed for the prediction of binding epitopes to H2d MHC class I and class II molecules, using online available algorithms. Based on in silico analysis, eight peptides including highly scored MHC class I- and class II-restricted epitopes were synthesized. Peptide immunogenicity was validated in MHC compatible BALB/c mice immunized with each synthetic peptide emulsified in CFA/IFA. CPA_p2, CPA_p3, H1_p1 and LeIF_p6 induced strong spleen cell proliferation upon in vitro peptide re-stimulation. In addition, the majority of the peptides, except of LeIF_p1 and KMP-11_p1, induced IFN-γ secretion, while KMP-11_p1 indicated a suppressive effect on IL-10 production. CPA_p2, CPA_p3, LeIF_p3 and LeIF_p6 induced IFN-γ-producing CD4+ T cells indicating a TH1 type response. In addition, CPA_p2, CPA_p3 and H1_p1 induced also the induction of CD8+ T cells. The induction of peptide-specific IgG in immunized mice designated also the existence of B cell epitopes in peptide sequences. Combining immunoinformatic tools and experimental validation, we demonstrated that CPA_p2, CPA_p3, H1_p1, H1_p3, CPA_p2, LeIF_p3 and LeIF_p6 are likely to include potential epitopes for the induction of protective cytotoxic and/or TH1-type immune responses supporting the feasibility of peptide-based vaccine development for leishmaniasis.

  8. Nanowire resonant tunneling diodes

    Science.gov (United States)

    Björk, M. T.; Ohlsson, B. J.; Thelander, C.; Persson, A. I.; Deppert, K.; Wallenberg, L. R.; Samuelson, L.

    2002-12-01

    Semiconductor heterostructures and their implementation into electronic and photonic devices have had tremendous impact on science and technology. In the development of quantum nanoelectronics, one-dimensional (1D) heterostructure devices are receiving a lot of interest. We report here functional 1D resonant tunneling diodes obtained via bottom-up assembly of designed segments of different semiconductor materials in III/V nanowires. The emitter, collector, and the central quantum dot are made from InAs and the barrier material from InP. Ideal resonant tunneling behavior, with peak-to-valley ratios of up to 50:1 and current densities of 1 nA/μm2 was observed at low temperatures.

  9. Cost-effective and rapid lysis of Saccharomyces cerevisiae cells for quantitative western blot analysis of proteins, including phosphorylated eIF2α.

    Science.gov (United States)

    Lee, Su Jung; Ramesh, Rashmi; de Boor, Valerie; Gebler, Jan M; Silva, Richard C; Sattlegger, Evelyn

    2017-09-01

    The common method for liberating proteins from Saccharomyces cerevisiae cells involves mechanical cell disruption using glass beads and buffer containing inhibitors (protease, phosphatase and/or kinase inhibitors), followed by centrifugation to remove cell debris. This procedure requires the use of costly inhibitors and is laborious, in particular when many samples need to be processed. Also, enzymatic reactions can still occur during harvesting and cell breakage. As a result low-abundance and labile proteins may be degraded, and enzymes such as kinases and phosphatases may still modify proteins during and after cell lysis. We believe that our rapid sample preparation method helps overcome the above issues and offers the following advantages: (a) it is cost-effective, as no inhibitors and breaking buffer are needed; (b) cell breakage is fast (about 15 min) since it only involves a few steps; (c) the use of formaldehyde inactivates endogenous proteases prior to cell lysis, dramatically reducing the risk of protein degradation; (d) centrifugation steps only occur prior to cell lysis, circumventing the problem of losing protein complexes, in particular if cells were treated with formaldehyde intended to stabilize and capture large protein complexes; and (e) since formaldehyde has the potential to instantly terminate protein activity, this method also allows the study of enzymes in live cells, i.e. in their true physiological environment, such as the short-term effect of a drug on enzyme activity. Taken together, the rapid sample preparation procedure provides a more accurate snapshot of the cell's protein content at the time of harvesting. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Hawking Radiation As Tunneling

    International Nuclear Information System (INIS)

    Parikh, Maulik K.; Wilczek, Frank

    2000-01-01

    We present a short and direct derivation of Hawking radiation as a tunneling process, based on particles in a dynamical geometry. The imaginary part of the action for the classically forbidden process is related to the Boltzmann factor for emission at the Hawking temperature. Because the derivation respects conservation laws, the exact spectrum is not precisely thermal. We compare and contrast the problem of spontaneous emission of charged particles from a charged conductor

  11. The beam dump tunnels

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    In these images workers are digging the tunnels that will be used to dump the counter-circulating beams. Travelling just a fraction under the speed of light, the beams at the LHC will each carry the energy of an aircraft carrier travelling at 12 knots. In order to dispose of these beams safely, a beam dump is used to extract the beam and diffuse it before it collides with a radiation shielded graphite target.

  12. Tunnel blasting - recent developments

    Energy Technology Data Exchange (ETDEWEB)

    White, T.E.

    1999-05-01

    While tunnelling machines are more efficient than previously, there are still areas where blasting is a more efficient method of advance. Drilling and design methods are increasingly sophisticated, as is choice of explosive. Explosive deployment must be carefully calculated so as to avoid desensitisation. Nitroglycerine may be used as slurries; bulk mixing on site of ANFO is also practised in mining in the UK. Electric detonators, Nonel tubes, and electronic detonators are also increasingly employed.

  13. Resonant Tunneling Spin Pump

    Science.gov (United States)

    Ting, David Z.

    2007-01-01

    The resonant tunneling spin pump is a proposed semiconductor device that would generate spin-polarized electron currents. The resonant tunneling spin pump would be a purely electrical device in the sense that it would not contain any magnetic material and would not rely on an applied magnetic field. Also, unlike prior sources of spin-polarized electron currents, the proposed device would not depend on a source of circularly polarized light. The proposed semiconductor electron-spin filters would exploit the Rashba effect, which can induce energy splitting in what would otherwise be degenerate quantum states, caused by a spin-orbit interaction in conjunction with a structural-inversion asymmetry in the presence of interfacial electric fields in a semiconductor heterostructure. The magnitude of the energy split is proportional to the electron wave number. Theoretical studies have suggested the possibility of devices in which electron energy states would be split by the Rashba effect and spin-polarized currents would be extracted by resonant quantum-mechanical tunneling.

  14. POINT CLOUD MODELLING BASED ON THE TUNNEL AXIS AND BLOCK ESTIMATION FOR MONITORING THE BADALING TUNNEL, CHINA

    Directory of Open Access Journals (Sweden)

    J. Wang

    2017-09-01

    Full Text Available Recent years have witnessed a growing investigation of terrestrial laser scanning (TLS for monitoring the deformation of tunnels. TLS provides the ability to obtain a more accurate and complete description of the tunnel surfaces, allowing the determination of the mechanism and magnitude of tunnel deformation, because the entire surface of the tunnel is more concretely modelled rather than being represented by a number of points. This paper models and analyses the point clouds from TLS to detect the possible deformation of a newly built tunnel. In the application of monitoring the Badaling Tunnel for the Winter Olympics 2020 in Beijing, China, the proposed method includes the following components: the tunnel axis is automatically estimated based on a 3D quadratic form estimation; all of the point clouds are segmented into axis-based blocks; and representative points, solved by a singular value decomposition (SVD method, are estimated to describe the tunnel surface and establish the correspondence of data between days. The deformations are detected in the form of the distance discrepancies of representative points and verified by the measurements using total station.

  15. Effect of brining on the drying rate of tilapia in a solar tunnel dryer

    Energy Technology Data Exchange (ETDEWEB)

    Kituu, G.M.; Shitanda, D.; Kanali, C.L.; Mailutha, J.T. [Jomo Kenyatta Univ. of Agriculture and Technology, Nairobi (Kenya). BEED

    2008-07-01

    In addition to being a source of protein, fish is an important source of local and foreign currency earnings in Kenya. A substantial amount of fish production is exported. Approximately 30 per cent is exported to the European Union, the United States, and countries in the Middle East, but nearly half of the total annual fish harvest in Kenya goes to waste due to poor processing and preservation. Measures must be taken to ensure the fish industry is protected and waste is minimized, since the livelihood of over 500,000 people depends on fish as a source of proteins and employment. Therefore, it is necessary to implement appropriate and affordable processing and preservation techniques for fish at the artisanal landing sites in order to reduce the wastage and spoilage of fish during oversupply, and to enhance long storage. This paper presented studies that were conducted to determine the effect of brining on the drying rate of tilapia in a solar tunnel dryer. The paper discussed the materials and methods, including a description of the solar tunnel dryer system; the brining process of fish; the fish drying process; and data analysis. It was concluded that limiting the amount of salt used in brining, and subsequently dehydrating fish with a solar tunnel dryer achieves a more stable and suitable dried fish product than osmotic dehydration or solar drying process separately. 19 refs., 5 figs., 2 appendices.

  16. Heavy-Atom Tunneling Calculations in Thirteen Organic Reactions: Tunneling Contributions are Substantial, and Bell's Formula Closely Approximates Multidimensional Tunneling at ≥250 K.

    Science.gov (United States)

    Doubleday, Charles; Armas, Randy; Walker, Dana; Cosgriff, Christopher V; Greer, Edyta M

    2017-10-09

    Multidimensional tunneling calculations are carried out for 13 reactions, to test the scope of heavy-atom tunneling in organic chemistry, and to check the accuracy of one-dimensional tunneling models. The reactions include pericyclic, cycloaromatization, radical cyclization and ring opening, and S N 2. When compared at the temperatures that give the same effective rate constant of 3×10 -5  s -1 , tunneling accounts for 25-95 % of the rate in 8 of the 13 reactions. Values of transmission coefficients predicted by Bell's formula, κ Bell  , agree well with multidimensional tunneling (canonical variational transition state theory with small curvature tunneling), κ SCT . Mean unsigned deviations of κ Bell vs. κ SCT are 0.08, 0.04, 0.02 at 250, 300 and 400 K. This suggests that κ Bell is a useful first choice for predicting transmission coefficients in heavy-atom tunnelling. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Ferroelectric tunneling element and memory applications which utilize the tunneling element

    Science.gov (United States)

    Kalinin, Sergei V [Knoxville, TN; Christen, Hans M [Knoxville, TN; Baddorf, Arthur P [Knoxville, TN; Meunier, Vincent [Knoxville, TN; Lee, Ho Nyung [Oak Ridge, TN

    2010-07-20

    A tunneling element includes a thin film layer of ferroelectric material and a pair of dissimilar electrically-conductive layers disposed on opposite sides of the ferroelectric layer. Because of the dissimilarity in composition or construction between the electrically-conductive layers, the electron transport behavior of the electrically-conductive layers is polarization dependent when the tunneling element is below the Curie temperature of the layer of ferroelectric material. The element can be used as a basis of compact 1R type non-volatile random access memory (RAM). The advantages include extremely simple architecture, ultimate scalability and fast access times generic for all ferroelectric memories.

  18. Soldier use of dietary supplements, including protein and body building supplements, in a combat zone is different than use in garrison.

    Science.gov (United States)

    Austin, Krista G; McLellan, Tom M; Farina, Emily K; McGraw, Susan M; Lieberman, Harris R

    2016-01-01

    United States Army personnel in garrison who are not deployed to combat theater report using dietary supplements (DSs) to promote health, increase physical and mental strength, and improve energy levels. Given the substantial physical and cognitive demands of combat, DS use may increase during deployment. This study compared DS use by garrison soldiers with DS use by personnel deployed to a combat theater in Afghanistan. Prevalence and patterns of DS use, demographic factors, and health behaviors were assessed by survey (deployed n = 221; garrison n = 1001). Eighty-two percent of deployed and 74% of garrison soldiers used DSs ≥ 1 time·week(-1). Logistic regression analyses, adjusted for significant demographic and health predictors of DS use, showed deployed personnel were more likely than garrison soldiers to use protein, amino acids, and combination products. Deployed females were more likely to use protein supplements and deployed males were more likely to use multivitamins, combination products, protein, and body building supplements than garrison respondents. Significantly more deployed (17%) than garrison (10%) personnel spent more than $50∙month(-1) on DSs. Higher protein supplement use among deployed personnel was associated with higher frequency of strength training and lower amounts of aerobic exercise for males but similar amounts of strength training and aerobic exercise for females. Protein supplements and combination products are used more frequently by deployed than garrison soldiers with the intent of enhancing strength and energy.

  19. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs

    DEFF Research Database (Denmark)

    Wu, R R; Couchman, J R

    1997-01-01

    obtained cDNA clones encoding the entire bamacan core protein of Mr = 138 kD, which reveal a five domain, head-rod-tail configuration. The head and tail are potentially globular, while the central large rod probably forms coiled-coil structures, with one large central and several very short interruptions....... The protein sequence has low overall homology, apart from very small NH2- and COOH-terminal motifs. At the junctions between the distal globular domains and the coiled-coil regions lie glycosylation sites, with up to three N-linked oligosaccharides and probably three chondroitin chains. Three other Ser...

  20. High-resolution computed tomography of the wrist in patients with carpal tunnel syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Merhar, G.L.; Clark, R.A.; Schneider, H.J.; Stern, P.J.

    1986-10-01

    High resolution computed tomography (CT) was used to scan the wrists of 19 patients with idiopathic carpal tunnel syndrome. Thirteen normal volunteers were used as controls. Measurements obtained from the CT images included the cross-sectional area of the carpal tunnel, the relative amount of synovium within the carpal tunnel, the attenuation coefficient of the carpal tunnel, and the thickness of the transverse carpal ligament. No significant difference in any of these measurements was found when comparing the wrists of symptomatic patients with controls. High resolution CT of the wrist does not appear to be of value in the preoperative evaluation of patients with idiopathic carpal tunnel syndrome.

  1. Scanning tunneling microscope assembly, reactor, and system

    Science.gov (United States)

    Tao, Feng; Salmeron, Miquel; Somorjai, Gabor A

    2014-11-18

    An embodiment of a scanning tunneling microscope (STM) reactor includes a pressure vessel, an STM assembly, and three spring coupling objects. The pressure vessel includes a sealable port, an interior, and an exterior. An embodiment of an STM system includes a vacuum chamber, an STM reactor, and three springs. The three springs couple the STM reactor to the vacuum chamber and are operable to suspend the scanning tunneling microscope reactor within the interior of the vacuum chamber during operation of the STM reactor. An embodiment of an STM assembly includes a coarse displacement arrangement, a piezoelectric fine displacement scanning tube coupled to the coarse displacement arrangement, and a receiver. The piezoelectric fine displacement scanning tube is coupled to the coarse displacement arrangement. The receiver is coupled to the piezoelectric scanning tube and is operable to receive a tip holder, and the tip holder is operable to receive a tip.

  2. Expression of complement binding proteins (CD55 and CD59) on spermatozoa of patients included in the program for assisted reproduction

    Czech Academy of Sciences Publication Activity Database

    Djarkova, T.; Mollova, M.; Ivanova, M.; Pěknicová, Jana; Todorov, P.; Dimitrov, J.

    2001-01-01

    Roč. 10, - (2001), s. 5-9 ISSN 0303-4569 R&D Projects: GA MŠk EU1985 Keywords : assisted reproduction * spermatozoa * proteins CD55, CD59 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.732, year: 2001

  3. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

    DEFF Research Database (Denmark)

    Mancini, Sarah J; White, Anna D; Bijland, Silvia

    2017-01-01

    Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-inflammatory actions in adipose tissue, yet the m...

  4. Thermovoltages in vacuum tunneling investigated by scanning tunneling microscopy

    OpenAIRE

    Hoffmann, D. H.; Rettenberger, Armin; Grand, Jean Yves; Läuger, K.; Leiderer, Paul; Dransfeld, Klaus; Möller, Rolf

    1995-01-01

    By heating the tunneling tip of a scanning tunneling microscope the thermoelectric properties of a variable vacuum barrier have been investigated. The lateral variation of the observed thermovoltage will be discussed for polycrystalline gold, stepped surfaces of silver, as well as for copper islands on silver.

  5. Reduced resistance drift in tunnel junctions using confined tunnel barriers

    Science.gov (United States)

    Barcikowski, Z. S.; Pomeroy, J. M.

    2017-11-01

    Metal-insulator-metal (MIM) tunnel junctions with the aluminum oxide tunnel barriers confined between cobalt electrodes exhibit less resistance drift over time than junctions that utilize a thick, unconfined aluminum electrode. The improved long time stability is attributed to better initial oxide quality achieved through confinement (use of a potential energy well for the oxygen) and plasma oxidation. In this work, Co/AlOx/Co and Co/Al/AlOx/Co tunnel junction aging is compared over a period of approximately 9 months using transport measurements and Wentzel-Kramers-Brillouin (WKB) based modelling. The Co/AlOx/Co (confined) tunnel junction resistance increased by (32 ± 6) % over 5400 h, while Co/Al/AlOx/Co (unconfined) tunnel junction resistance increased by (85 ± 23) % over 5200 h. Fit parameters for the tunnel barrier width and potential energy barriers were extracted using WKB transport modelling. These values change only a small amount in the confined Co/AlOx/Co tunnel junction but show a significant drift in the unconfined Co/AlOx/Co tunnel junction.

  6. Fundamental visual problems in tunnels : sumposium on tunnel lighting.

    NARCIS (Netherlands)

    Schreuder, D.A.

    2018-01-01

    Tunnels and underpasses are likely to play a greater part in our future road network. Daytime lighting for tunnel entrances represents a considerable proportion of their total running costs and it is important that the right solution should be found. Guidance is given in CIE Publication No. 26

  7. Engineers win award for Swiss tunnel

    CERN Multimedia

    2003-01-01

    A Derby engineering consultancy has won the Tunnelling Industry Award 2003 for Excellence in Tunnel Design, offered by the British Tunnelling Society, for its work on the LHC in Geneva, Switzerland (1/2 page).

  8. Thermodynamics inducing massive particles' tunneling and cosmic censorship

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Baocheng [Chinese Academy of Sciences, State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Wuhan (China); Graduate University of Chinese Academy of Sciences, Beijing (China); Cai, Qing-yu [Chinese Academy of Sciences, State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Wuhan (China); Zhan, Ming-sheng [Chinese Academy of Sciences, State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Wuhan (China); Chinese Academy of Sciences, Center for Cold Atom Physics, Wuhan (China)

    2010-08-15

    By calculating the change of entropy, we prove that the first law of black hole thermodynamics leads to the tunneling probability of massive particles through the horizon, including the tunneling probability of massive charged particles from the Reissner-Nordstroem black hole and the Kerr-Newman black hole. Novelly, we find the trajectories of massive particles are close to that of massless particles near the horizon, although the trajectories of massive charged particles may be affected by electromagnetic forces. We show that Hawking radiation as massive particles tunneling does not lead to violation of the weak cosmic-censorship conjecture. (orig.)

  9. Tunneling-assisted transport of carriers through heterojunctions.

    Energy Technology Data Exchange (ETDEWEB)

    Wampler, William R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Myers, Samuel M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Modine, Normand A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    The formulation of carrier transport through heterojunctions by tunneling and thermionic emission is derived from first principles. The treatment of tunneling is discussed at three levels of approximation: numerical solution of the one-band envelope equation for an arbitrarily specified potential profile; the WKB approximation for an arbitrary potential; and, an analytic formulation assuming constant internal field. The effects of spatially varying carrier chemical potentials over tunneling distances are included. Illustrative computational results are presented. The described approach is used in exploratory physics models of irradiated heterojunction bipolar transistors within Sandia's QASPR program.

  10. Counter Tunnel Project

    Science.gov (United States)

    2014-03-01

    DSP-3000 fiber - optic gyro , MicroStrain 3DM-GX2 IMU, with USB and Ethernet connec- tors. Small enough to fit into all the tunnels that were explored...frame arms were sufficient for de- ployment of the RDC. Gigabit multi-mode fiber - optic communication and 48 VDC power were passed to the RDC through...with AcuAMP ACT050 current sensors. The control box monitoring all of the information, as well as the source of the 48 VDC and fiber - optic cable to

  11. Icing Research Tunnel

    Science.gov (United States)

    Chennault, Jonathan

    2004-01-01

    The Icing Research Tunnel in Building 11 at the NASA Glenn Research Center is committed to researching the effects of in flight icing on aircraft and testing ways to stop the formation of hazardous icing conditions on planes. During this summer, I worked here with Richard DelRosa, the lead engineer for this area. address one of the major concerns of aviation: icing conditions. During the war, many planes crashed (especially supply planes going over the.Himalayas) because ice built up in their wings and clogged the engines. To this day, it remains the largest ice tunnel in the world, with a test section that measures 6 feet high, 9 feet long, and 20 feet wide. It can simulate airspeeds from 50 to 300 miles per hour at temperatures as low as -50 Fahrenheit. Using these capabilities, IRT can simulate actual conditions at high altitudes. The first thing I did was creating a cross reference in Microsoft Excel. It lists commands for the DPU units that control the pressure and temperature variations in the tunnel, as well as the type of command (keyboard, multiplier, divide, etc). The cross reference also contains the algorithm for every command, and which page it is listed in on the control sheet (visual Auto-CAD graphs, which I helped to make). I actually spent most of the time on the computer using Auto-CAD. I drew a diagram of the entire icing tunnel and then drew diagrams of its various parts. Between my mentor and me, we have drawings of every part of it, from the spray bars to the thermocouples, power cabinets, input-output connectors for power systems, and layouts of various other machines. I was also responsible for drawing schematics for the Escort system (which controls the spray bars), the power system, DPUs, and other electrical systems. In my spare time, I am attempting to build and program the "toddler". Toddler is a walking robot that I have to program in PBASIC language. When complete, it should be able to walk on level terrain while avoiding obstacles in

  12. Identification of 17 HrpX-regulated proteins including two novel type III effectors, XOC_3956 and XOC_1550, in Xanthomonas oryzae pv. oryzicola.

    Science.gov (United States)

    Xue, Xiao-bo; Zou, Li-fang; Ma, Wen-xiu; Liu, Zhi-yang; Chen, Gong-you

    2014-01-01

    The function of some hypothetical proteins, possibly regulated by key hrp regulators, in the pathogenicity of phytopathogenic bacteria remains largely unknown. In the present study, in silicon microarray data demonstrated that the expression of 17 HrpX-regulated protein (Xrp) genes of X. oryzae pv. oryzicola (Xoc), which causes bacterial leaf streak in rice, were either positively or negatively regulated by HrpX or/and HrpG. Bioinformatics analysis demonstrated that five Xrps possess a putative type III secretion (T3S) signal in the first 50 N-terminal amino acids, six xrp genes contain a PIP-box-like sequence (TTCGB-NX-TTCGB, 9 ≤ X ≤ 25) in the promoter regions, and two Xrps have both motifs. Twelve Xrps are widely conserved in Xanthomonas spp., whereas four are specific for X. oryzae (Xrp6) or Xoc (Xrp8, Xrp14 and Xrp17). In addition to the regulation by HrpG/HrpX, some of the 17 genes were also modulated by another hrp regulator HrpD6. Mutagenesis of these 17 genes indicated that five Xrps (Xrp1, Xrp2, Xrp5, Xrp8 and Xrp14) were required for full virulence and bacterial growth in planta. Immunoblotting assays and fusion with N-terminally truncated AvrXa10 indicated that Xrp3 and Xrp5 were secreted and translocated into rice cells through the type-III secretion system (T3S), suggesting they are novel T3S effectors. Our results suggest that Xoc exploits an orchestra of proteins that are regulated by HrpG, HrpX and HrpD6, and these proteins facilitate both infection and metabolism.

  13. Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein.

    Science.gov (United States)

    Apitz, Janina; Nishimura, Kenji; Schmied, Judith; Wolf, Anja; Hedtke, Boris; van Wijk, Klaas J; Grimm, Bernhard

    2016-04-01

    5-Aminolevulinic acid (ALA) is the first committed substrate of tetrapyrrole biosynthesis and is formed from glutamyl-tRNA by two enzymatic steps. Glutamyl-tRNA reductase (GluTR) as the first enzyme of ALA synthesis is encoded by HEMA genes and tightly regulated at the transcriptional and posttranslational levels. Here, we show that the caseinolytic protease (Clp) substrate adaptor ClpS1 and the ClpC1 chaperone as well as the GluTR-binding protein (GBP) interact with the N terminus of GluTR Loss-of function mutants of ClpR2 and ClpC1 proteins show increased GluTR stability, whereas absence of GBP results in decreased GluTR stability. Thus, the Clp protease system and GBP contribute to GluTR accumulation levels, and thereby the rate-limiting ALA synthesis. These findings are supported with Arabidopsis (Arabidopsis thaliana) hema1 mutants expressing a truncated GluTR lacking the 29 N-terminal amino acid residues of the mature protein. Accumulation of this truncated GluTR is higher in dark periods, resulting in increased protochlorophyllide content. It is proposed that the proteolytic activity of Clp protease counteracts GBP binding to assure the appropriate content of GluTR and the adequate ALA synthesis for chlorophyll and heme in higher plants. © 2016 American Society of Plant Biologists. All Rights Reserved.

  14. Simulation of nanowire tunneling transistors: From the Wentzel-Kramers-Brillouin approximation to full-band phonon-assisted tunneling

    Science.gov (United States)

    Luisier, Mathieu; Klimeck, Gerhard

    2010-04-01

    Nanowire band-to-band tunneling field-effect transistors (TFETs) are simulated using the Wentzel-Kramers-Brillouin (WKB) approximation and an atomistic, full-band quantum transport solver including direct and phonon-assisted tunneling (PAT). It is found that the WKB approximation properly works if one single imaginary path connecting the valence band (VB) and the conduction band (CB) dominates the tunneling process as in direct band gap semiconductors. However, PAT is essential in Si and Ge nanowire TFETs where multiple, tightly-coupled, imaginary paths exist between the VB and the CB.

  15. Restoring proximal caries lesions conservatively with tunnel restorations

    Directory of Open Access Journals (Sweden)

    Chu CH

    2013-07-01

    Full Text Available Chun-Hung Chu1, May L Mei,1 Chloe Cheung,1 Romesh P Nalliah2 1Faculty of Dentistry, The University of Hong Kong, Hong Kong, People's Republic of China; 2Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA, USA Abstract: The tunnel restoration has been suggested as a conservative alternative to the conventional box preparation for treating proximal caries. The main advantage of tunnel restoration over the conventional box or slot preparation includes being more conservative and increasing tooth integrity and strength by preserving the marginal ridge. However, tunnel restoration is technique-sensitive and can be particularly challenging for inexperienced restorative dentists. Recent advances in technology, such as the contemporary design of dental handpieces with advanced light-emitting diode (LED and handheld comfort, offer operative dentists better vision, illumination, and maneuverability. The use of magnifying loupes also enhances the visibility of the preparation. The advent of digital radiographic imaging has improved dental imaging and reduced radiation. The new generation of restorative materials has improved mechanical properties. Tunnel restoration can be an option to restore proximal caries if the dentist performs proper case selection and pays attention to the details of the restorative procedures. This paper describes the clinical technique of tunnel restoration and reviews the studies of tunnel restorations. Keywords: operative, practice, tunnel preparation, composite, amalgam, glass ionomer

  16. Hawking temperature from tunnelling formalism

    OpenAIRE

    Mitra, P.

    2007-01-01

    It has recently been suggested that the attempt to understand Hawking radiation as tunnelling across black hole horizons produces a Hawking temperature double the standard value. It is explained here how one can obtain the standard value in the same tunnelling approach.

  17. Spin tunnelling in mesoscopic systems

    Indian Academy of Sciences (India)

    We study spin tunnelling in molecular magnets as an instance of a mesoscopic phenomenon, with special emphasis on the molecule Fe8. We show that the tunnel splitting between various pairs of Zeeman levels in this molecule oscillates as a function of applied magnetic field, vanishing completely at special points in the ...

  18. Carpal Tunnel Syndrome (For Kids)

    Science.gov (United States)

    ... First Aid & Safety Doctors & Hospitals Videos Recipes for Kids Kids site Sitio para niños How the Body Works ... Search English Español Carpal Tunnel Syndrome KidsHealth / For Kids / Carpal Tunnel Syndrome What's in this article? Where ...

  19. Amino acid profiles of rumen undegradable protein: a comparison between forages including cereal straws and alfalfa and their respective total mixed rations.

    Science.gov (United States)

    Wang, B; Jiang, L S; Liu, J X

    2017-10-06

    Optimizing the amino acid (AA) profile of rumen undegradable protein (RUP) can positively affect the amount of milk protein. This study was conducted to improve knowledge regarding the AA profile of rumen undegradable protein from corn stover, rice straw and alfalfa hay as well as the total mixed ratio diets (TMR) based on one of them as forage source [forage-to-concentrate ratio of 45:55 (30% of corn stover (CS), 30% of rice straw (RS), 23% of alfalfa hay (AH) and dry matter basis)]. The other ingredients in the three TMR diets were similar. The RUP of all the forages and diets was estimated by incubation for 16 hr in the rumen of three ruminally cannulated lactating cows. All residues were corrected for microbial colonization, which was necessary in determining the AA composition of RUP from feed samples using in situ method. Compared with their original AA composition, the AA pattern of forages and forage-based diets changed drastically after rumen exposure. In addition, the extent of ruminal degradation of analysed AA was not constant among the forages. The greatest individual AA degradability of alfalfa hay and corn stover was Pro, but was His of rice straw. A remarkable difference was observed between microbial attachment corrected and uncorrected AA profiles of RUP, except for alfalfa hay and His in the three forages and TMR diets. The ruminal AA degradability of cereal straws was altered compared with alfalfa hay but not for the TMR diets. In summary, the AA composition of forages and TMR-based diets changed significantly after ruminal exposure, indicating that the original AA profiles of the feed cannot represent its AA composition of RUP. The AA profile of RUP and ruminal AA degradability for corn stover and rice straw contributed to missing information in the field. © 2017 Blackwell Verlag GmbH.

  20. EspC, an Autotransporter Protein Secreted by Enteropathogenic Escherichia coli, Causes Apoptosis and Necrosis through Caspase and Calpain Activation, Including Direct Procaspase-3 Cleavage

    Directory of Open Access Journals (Sweden)

    Antonio Serapio-Palacios

    2016-06-01

    Full Text Available Enteropathogenic Escherichia coli (EPEC has the ability to antagonize host apoptosis during infection through promotion and inhibition of effectors injected by the type III secretion system (T3SS, but the total number of these effectors and the overall functional relationships between these effectors during infection are poorly understood. EspC produced by EPEC cleaves fodrin, paxillin, and focal adhesion kinase (FAK, which are also cleaved by caspases and calpains during apoptosis. Here we show the role of EspC in cell death induced by EPEC. EspC is involved in EPEC-mediated cell death and induces both apoptosis and necrosis in epithelial cells. EspC induces apoptosis through the mitochondrial apoptotic pathway by provoking (i a decrease in the expression levels of antiapoptotic protein Bcl-2, (ii translocation of the proapoptotic protein Bax from cytosol to mitochondria, (iii cytochrome c release from mitochondria to the cytoplasm, (iv loss of mitochondrial membrane potential, (v caspase-9 activation, (vi cleavage of procaspase-3 and (vii an increase in caspase-3 activity, (viii PARP proteolysis, and (ix nuclear fragmentation and an increase in the sub-G1 population. Interestingly, EspC-induced apoptosis was triggered through a dual mechanism involving both independent and dependent functions of its EspC serine protease motif, the direct cleavage of procaspase-3 being dependent on this motif. This is the first report showing a shortcut for induction of apoptosis by the catalytic activity of an EPEC protein. Furthermore, this atypical intrinsic apoptosis appeared to induce necrosis through the activation of calpain and through the increase of intracellular calcium induced by EspC. Our data indicate that EspC plays a relevant role in cell death induced by EPEC.

  1. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs

    DEFF Research Database (Denmark)

    Wu, R R; Couchman, J R

    1997-01-01

    obtained cDNA clones encoding the entire bamacan core protein of Mr = 138 kD, which reveal a five domain, head-rod-tail configuration. The head and tail are potentially globular, while the central large rod probably forms coiled-coil structures, with one large central and several very short interruptions....../translation product from a full-length bamacan cDNA. The unusual structure of this proteoglycan is indicative of specific functional roles in basement membrane physiology, commensurate with its distinct expression in development and changes in disease models....

  2. Dynamic Regulation of a Cell Adhesion Protein Complex Including CADM1 by Combinatorial Analysis of FRAP with Exponential Curve-Fitting

    Science.gov (United States)

    Sakurai-Yageta, Mika; Maruyama, Tomoko; Suzuki, Takashi; Ichikawa, Kazuhisa; Murakami, Yoshinori

    2015-01-01

    Protein components of cell adhesion machinery show continuous renewal even in the static state of epithelial cells and participate in the formation and maintenance of normal epithelial architecture and tumor suppression. CADM1 is a tumor suppressor belonging to the immunoglobulin superfamily of cell adhesion molecule and forms a cell adhesion complex with an actin-binding protein, 4.1B, and a scaffold protein, MPP3, in the cytoplasm. Here, we investigate dynamic regulation of the CADM1-4.1B-MPP3 complex in mature cell adhesion by fluorescence recovery after photobleaching (FRAP) analysis. Traditional FRAP analysis were performed for relatively short period of around 10min. Here, thanks to recent advances in the sensitive laser detector systems, we examine FRAP of CADM1 complex for longer period of 60 min and analyze the recovery with exponential curve-fitting to distinguish the fractions with different diffusion constants. This approach reveals that the fluorescence recovery of CADM1 is fitted to a single exponential function with a time constant (τ) of approximately 16 min, whereas 4.1B and MPP3 are fitted to a double exponential function with two τs of approximately 40-60 sec and 16 min. The longer τ is similar to that of CADM1, suggesting that 4.1B and MPP3 have two distinct fractions, one forming a complex with CADM1 and the other present as a free pool. Fluorescence loss in photobleaching analysis supports the presence of a free pool of these proteins near the plasma membrane. Furthermore, double exponential fitting makes it possible to estimate the ratio of 4.1B and MPP3 present as a free pool and as a complex with CADM1 as approximately 3:2 and 3:1, respectively. Our analyses reveal a central role of CADM1 in stabilizing the complex with 4.1B and MPP3 and provide insight in the dynamics of adhesion complex formation. PMID:25780926

  3. Dynamic regulation of a cell adhesion protein complex including CADM1 by combinatorial analysis of FRAP with exponential curve-fitting.

    Science.gov (United States)

    Sakurai-Yageta, Mika; Maruyama, Tomoko; Suzuki, Takashi; Ichikawa, Kazuhisa; Murakami, Yoshinori

    2015-01-01

    Protein components of cell adhesion machinery show continuous renewal even in the static state of epithelial cells and participate in the formation and maintenance of normal epithelial architecture and tumor suppression. CADM1 is a tumor suppressor belonging to the immunoglobulin superfamily of cell adhesion molecule and forms a cell adhesion complex with an actin-binding protein, 4.1B, and a scaffold protein, MPP3, in the cytoplasm. Here, we investigate dynamic regulation of the CADM1-4.1B-MPP3 complex in mature cell adhesion by fluorescence recovery after photobleaching (FRAP) analysis. Traditional FRAP analysis were performed for relatively short period of around 10 min. Here, thanks to recent advances in the sensitive laser detector systems, we examine FRAP of CADM1 complex for longer period of 60 min and analyze the recovery with exponential curve-fitting to distinguish the fractions with different diffusion constants. This approach reveals that the fluorescence recovery of CADM1 is fitted to a single exponential function with a time constant (τ) of approximately 16 min, whereas 4.1B and MPP3 are fitted to a double exponential function with two τs of approximately 40-60 sec and 16 min. The longer τ is similar to that of CADM1, suggesting that 4.1B and MPP3 have two distinct fractions, one forming a complex with CADM1 and the other present as a free pool. Fluorescence loss in photobleaching analysis supports the presence of a free pool of these proteins near the plasma membrane. Furthermore, double exponential fitting makes it possible to estimate the ratio of 4.1B and MPP3 present as a free pool and as a complex with CADM1 as approximately 3:2 and 3:1, respectively. Our analyses reveal a central role of CADM1 in stabilizing the complex with 4.1B and MPP3 and provide insight in the dynamics of adhesion complex formation.

  4. Tunneling in thin MOS structures

    Science.gov (United States)

    Maserjian, J.

    1974-01-01

    Recent results on tunneling in thin MOS structures are described. Thermally grown SiO2 films in the thickness range of 22-40 A have been shown to be effectively uniform on an atomic scale and exhibit an extremely abrupt oxide-silicon interface. Resonant reflections are observed at this interface for Fowler-Nordheim tunneling and are shown to agree with the exact theory for a trapezoidal barrier. Tunneling at lower fields is consistent with elastic tunneling into the silicon direct conduction band and, at still lower fields, inelastic tunneling into the indirect conduction band. Approximate dispersion relations are obtained over portions of the silicon-dioxide energy gap and conduction band.

  5. Research on he Classification of Life-Cycle Safety Monitoring Levels of Subsea Tunnels

    Directory of Open Access Journals (Sweden)

    Lu Junfu

    2017-08-01

    Full Text Available As a traffic engineering project across straits or gulfs, subsea tunnel is one of the oceaneering with great construction difficulties, and the key to the success of subsea tunnel engineering lies in timely and accurate assessment of the structure safety of subsea tunnel engineering construction and life-cycle. Xiang’an Xiamen subsea tunnel is China’s first subsea tunnel which crosses complex formation conditions, engineering accidents such as collapse, sudden inflow of water or mud might occur during tunnel construction and operation. Therefore, the concept of subsea tunnel life-cycle monitoring is proposed aiming at the particularity of subsea tunnels. The variation forms of subsea tunnel mainly include large deformation, collapse, primary support cracking, water leakage, water pressure increase, steel arch corrosion, concrete corrosion, longitudinal differential settlement, etc., and classification of the life-cycle safety monitoring levels of the subsea tunnel is conducted based on risk assessment theory and risk level management benchmark to determine the possible variation forms in the monitoring level segments. The research results will provide reference for the subsea tunnel life-cycle monitoring, disaster warning as well as risk management under construction or to be built at home and abroad.

  6. Efficacy of humidity retention bags for the reduced adsorption and improved cleaning of tissue proteins including prion-associated amyloid to surgical stainless steel surfaces.

    Science.gov (United States)

    Secker, T J; Pinchin, H E; Hervé, R C; Keevil, C W

    2015-01-01

    Increasing drying time adversely affects attachment of tissue proteins and prion-associated amyloid to surgical stainless steel, and reduces the efficacy of commercial cleaning chemistries. This study tested the efficacy of commercial humidity retention bags to reduce biofouling on surgical stainless steel and to improve subsequent cleaning. Surgical stainless steel surfaces were contaminated with ME7-infected brain homogenates and left to dry for 15 to 1,440 min either in air, in dry polythene bags or within humidity retention bags. Residual contamination pre/post cleaning was analysed using Thioflavin T/SYPRO Ruby dual staining and microscope analysis. An increase in biofouling was observed with increased drying time in air or in sealed dry bags. Humidity retention bags kept both protein and prion-associated amyloid minimal across the drying times both pre- and post-cleaning. Therefore, humidity bags demonstrate a cheap, easy to implement solution to improve surgical instrument reprocessing and to potentially reduce associated hospital acquired infections.

  7. Wind Tunnel Management and Resource Optimization: A Systems Modeling Approach

    Science.gov (United States)

    Jacobs, Derya, A.; Aasen, Curtis A.

    2000-01-01

    Time, money, and, personnel are becoming increasingly scarce resources within government agencies due to a reduction in funding and the desire to demonstrate responsible economic efficiency. The ability of an organization to plan and schedule resources effectively can provide the necessary leverage to improve productivity, provide continuous support to all projects, and insure flexibility in a rapidly changing environment. Without adequate internal controls the organization is forced to rely on external support, waste precious resources, and risk an inefficient response to change. Management systems must be developed and applied that strive to maximize the utility of existing resources in order to achieve the goal of "faster, cheaper, better". An area of concern within NASA Langley Research Center was the scheduling, planning, and resource management of the Wind Tunnel Enterprise operations. Nine wind tunnels make up the Enterprise. Prior to this research, these wind tunnel groups did not employ a rigorous or standardized management planning system. In addition, each wind tunnel unit operated from a position of autonomy, with little coordination of clients, resources, or project control. For operating and planning purposes, each wind tunnel operating unit must balance inputs from a variety of sources. Although each unit is managed by individual Facility Operations groups, other stakeholders influence wind tunnel operations. These groups include, for example, the various researchers and clients who use the facility, the Facility System Engineering Division (FSED) tasked with wind tunnel repair and upgrade, the Langley Research Center (LaRC) Fabrication (FAB) group which fabricates repair parts and provides test model upkeep, the NASA and LARC Strategic Plans, and unscheduled use of the facilities by important clients. Expanding these influences horizontally through nine wind tunnel operations and vertically along the NASA management structure greatly increases the

  8. Photogrammetry Applied to Wind Tunnel Testing

    Science.gov (United States)

    Liu, Tian-Shu; Cattafesta, L. N., III; Radeztsky, R. H.; Burner, A. W.

    2000-01-01

    In image-based measurements, quantitative image data must be mapped to three-dimensional object space. Analytical photogrammetric methods, which may be used to accomplish this task, are discussed from the viewpoint of experimental fluid dynamicists. The Direct Linear Transformation (DLT) for camera calibration, used in pressure sensitive paint, is summarized. An optimization method for camera calibration is developed that can be used to determine the camera calibration parameters, including those describing lens distortion, from a single image. Combined with the DLT method, this method allows a rapid and comprehensive in-situ camera calibration and therefore is particularly useful for quantitative flow visualization and other measurements such as model attitude and deformation in production wind tunnels. The paper also includes a brief description of typical photogrammetric applications to temperature- and pressure-sensitive paint measurements and model deformation measurements in wind tunnels.

  9. Cloning and characterization of miRNAs and their targets, including a novel miRNA-targeted NBS-LRR protein class gene in apple (Golden Delicious).

    Science.gov (United States)

    Ma, Chao; Lu, You; Bai, Songlin; Zhang, Wennan; Duan, Xuwei; Meng, Dong; Wang, Zhigang; Wang, Aide; Zhou, Zongshan; Li, Tianzhong

    2014-01-01

    MicroRNA (miRNA) has emerged as an important regulator of gene expression in plants. 146 miRNAs were identified from apple (Malus domestica cv. Golden Delicious) by bioinformatic analysis and RNA library sequencing. From these, 135 were conserved and 11 were novel miRNAs. Target analysis predicted one of the novel miRNAs, Md-miRLn11 (Malus domestica microRNA Ln11), targeted an apple nucleotide-binding site (NBS)-leucine-rich repeat (LRR) class protein coding gene (Md-NBS). 5' RACE assay confirmed the ability of Md-miRLn11 to cleave Md-NBS at the 11-12-nt position. Analysis of the expression of Md-miRLn11 and Md-NBS during the optimum invasion period in 40 apple varieties showed that the expression of Md-NBS gene in resistant varieties is higher than in susceptible varieties, with an inverse pattern for Md-miRLn11. Seedlings from the resistant apple variety 'JiGuan' were used to carry out an Agrobacterium infiltration assay, and then inoculated with the apple leaf spot disease. The result showed a clear decline of disease resistance in JiGuan apples. In contrast, the susceptible variety 'FuJi' infiltrated with the Md-NBS gene showed a significant increase in disease resistance. Based on the above results, we propose that Md-miRLn11 regulates Md-NBS gene expression in particular under the condition of pathogen infection, and that the Md-miRLn11 targeting P-loop site may regulate many NBS-LRR protein class genes in woody plants.

  10. A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome.

    Science.gov (United States)

    Guevara-Cruz, Martha; Tovar, Armando R; Aguilar-Salinas, Carlos A; Medina-Vera, Isabel; Gil-Zenteno, Lidia; Hernández-Viveros, Isaac; López-Romero, Patricia; Ordaz-Nava, Guillermo; Canizales-Quinteros, Samuel; Guillen Pineda, Luz E; Torres, Nimbe

    2012-01-01

    Metabolic syndrome (MetS) is a health problem throughout the world and is associated with cardiovascular disease and diabetes. Thus, the purpose of the present work was to evaluate the effects of a dietary pattern (DP; soy protein, nopal, chia seed, and oat) on the biochemical variables of MetS, the AUC for glucose and insulin, glucose intolerance (GI), the relationship of the presence of certain polymorphisms related to MetS, and the response to the DP. In this randomized trial, the participants consumed their habitual diet but reduced by 500 kcal for 2 wk. They were then assigned to the placebo (P; n = 35) or DP (n = 32) group and consumed the reduced energy diet plus the P or DP beverage (235 kcal) minus the energy provided by these for 2 mo. All participants had decreases in body weight (BW), BMI, and waist circumference during the 2-mo treatment (P < 0.0001); however, only the DP group had decreases in serum TG, C-reactive protein (CRP), and AUC for insulin and GI after a glucose tolerance test. Interestingly, participants in the DP group with MetS and the ABCA1 R230C variant had a greater decrease in BW and an increase in serum adiponectin concentration after 2 mo of dietary treatment than those with the ABCA1 R230R variant. The results from this study suggest that lifestyle interventions involving specific DP for the treatment of MetS could be more effective if local foods and genetic variations of the population are considered.

  11. Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.

    Science.gov (United States)

    Greber, Basil Johannes; Gerhardy, Stefan; Leitner, Alexander; Leibundgut, Marc; Salem, Michèle; Boehringer, Daniel; Leulliot, Nicolas; Aebersold, Ruedi; Panse, Vikram Govind; Ban, Nenad

    2016-01-14

    Eukaryotic ribosome biogenesis depends on several hundred assembly factors to produce functional 40S and 60S ribosomal subunits. The final phase of 60S subunit biogenesis is cytoplasmic maturation, which includes the proofreading of functional centers of the 60S subunit and the release of several ribosome biogenesis factors. We report the cryo-electron microscopy (cryo-EM) structure of the yeast 60S subunit in complex with the biogenesis factors Rei1, Arx1, and Alb1 at 3.4 Å resolution. In addition to the network of interactions formed by Alb1, the structure reveals a mechanism for ensuring the integrity of the ribosomal polypeptide exit tunnel. Arx1 probes the entire set of inner-ring proteins surrounding the tunnel exit, and the C terminus of Rei1 is deeply inserted into the ribosomal tunnel, where it forms specific contacts along almost its entire length. We provide genetic and biochemical evidence that failure to insert the C terminus of Rei1 precludes subsequent steps of 60S maturation. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs including peptide and protein drugs in rats.

    Science.gov (United States)

    Alama, Tammam; Kusamori, Kosuke; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira

    2016-02-29

    In general, the intestinal absorption of small hydrophilic molecules and macromolecules like peptides, after oral administration is very poor. Absorption enhancers are considered to be one of the most promising agents to enhance the intestinal absorption of drugs. In this research, we focused on a gemini surfactant, a new type of absorption enhancer. The intestinal absorption of drugs, with or without sodium dilauramidoglutamide lysine (SLG-30), a gemini surfactant, was examined by an in situ closed-loop method in rats. The intestinal absorption of 5(6)-carboxyfluorescein (CF) and fluorescein isothiocyanate-dextrans (FDs) was significantly enhanced in the presence of SLG-30, such effect being reversible. Furthermore, the calcium levels in the plasma significantly decreased when calcitonin was co-administered with SLG-30, suggestive of the increased intestinal absorption of calcitonin. In addition, no significant increase in the of lactate dehydrogenase (LDH) activity or in protein release from the intestinal epithelium was observed in the presence of SLG-30, suggestive of the safety of this compound. These findings indicate that SLG-30 is an effective absorption-enhancer for improving the intestinal absorption of poorly absorbed drugs, without causing serious damage to the intestinal epithelium. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Organic tunnel field effect transistors

    KAUST Repository

    Tietze, Max Lutz

    2017-06-29

    Various examples are provided for organic tunnel field effect transistors (OTFET), and methods thereof. In one example, an OTFET includes a first intrinsic layer (i-layer) of organic semiconductor material disposed over a gate insulating layer; source (or drain) contact stacks disposed on portions of the first i-layer; a second i-layer of organic semiconductor material disposed on the first i-layer surrounding the source (or drain) contact stacks; an n-doped organic semiconductor layer disposed on the second i-layer; and a drain (or source) contact layer disposed on the n-doped organic semiconductor layer. The source (or drain) contact stacks can include a p-doped injection layer, a source (or drain) contact layer, and a contact insulating layer. In another example, a method includes disposing a first i-layer over a gate insulating layer; forming source or drain contact stacks; and disposing a second i-layer, an n-doped organic semiconductor layer, and a drain or source contact.

  14. Tunnel fire testing and modeling the Morgex North tunnel experiment

    CERN Document Server

    Borghetti, Fabio; Gandini, Paolo; Frassoldati, Alessio; Tavelli, Silvia

    2017-01-01

    This book aims to cast light on all aspects of tunnel fires, based on experimental activities and theoretical and computational fluid dynamics (CFD) analyses. In particular, the authors describe a transient full-scale fire test (~15 MW), explaining how they designed and performed the experimental activity inside the Morgex North tunnel in Italy. The entire organization of the experiment is described, from preliminary evaluations to the solutions found for management of operational difficulties and safety issues. This fire test allowed the collection of different measurements (temperature, air velocity, smoke composition, pollutant species) useful for validating and improving CFD codes and for testing the real behavior of the tunnel and its safety systems during a diesel oil fire with a significant heat release rate. Finally, the fire dynamics are compared with empirical correlations, CFD simulations, and literature measurements obtained in other similar tunnel fire tests. This book will be of interest to all ...

  15. KAERI underground research tunnel (KURT)

    International Nuclear Information System (INIS)

    Cho, Won Jin; Kwon, Sang Ki; Park, Jeong Hwa; Choi, Jong Won

    2007-01-01

    An underground research tunnel is essential to validate the integrity of a high-level waste disposal system, and the safety of geological disposal. In this study, KAERI underground research tunnel (KURT) was constructed in the site of Korea Atomic Energy Research Institute(KAERI). The results of the site investigation and the design of underground tunnel were presented. The procedure for the construction permits and the construction of KURT were described briefly. The in-situ experiments being carried out at KURT were also introduced

  16. Tunneling Ionization of Diatomic Molecules

    DEFF Research Database (Denmark)

    Svensmark, Jens Søren Sieg

    2016-01-01

    When a molecule is subject to a strong laser field, there is a probability that an electron can escape, even though the electrons are bound by a large potential barrier. This is possible because electrons are quantum mechanical in nature, and they are therefore able to tunnel through potential...... of tunneling ionizaion of molecules is presented and the results of numerical calculations are shown. One perhaps surprising result is, that the frequently used Born-Oppenheimer approximation breaks down for weak fields when describing tunneling ionization. An analytic theory applicable in the weak-field limit...

  17. Role of Wind Tunnels in Aircraft Design

    Indian Academy of Sciences (India)

    large wind tunnels simulating the actual flight conditions as nearly as possible. Often, several wind tunnels ... wind tunnel tests can be 'scaled' to the actual velocity and actual body size using suitable scaling laws. A typical wind tunnel consists ofa test section ... tion and control positions. Some of this instrumentation like six.

  18. 78 FR 46117 - National Tunnel Inspection Standards

    Science.gov (United States)

    2013-07-30

    ... busiest vehicular tunnel in the world. The Fort McHenry Tunnel handles a daily traffic volume of more than... vehicular, transit, and rail tunnels in the New York City metropolitan area. Although it is still too early... congestion along alternative routes, and save users both dollars and fuel. If these tunnels were closed due...

  19. Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including protein markers, pathogens and cellular debris

    Science.gov (United States)

    Martinez, Jennifer S [Santa Fe, NM; Swanson, Basil I [Los Alamos, NM; Grace, Karen M [Los Alamos, NM; Grace, Wynne K [Los Alamos, NM; Shreve, Andrew P [Santa Fe, NM

    2009-06-02

    An assay element is described including recognition ligands bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of a biological target is described including injecting a biological target-containing sample into a sensor cell including the assay element, with the recognition ligands adapted for binding to selected biological targets, maintaining the sample within the sensor cell for time sufficient for binding to occur between selected biological targets within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting the fluorescent-label in any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.

  20. Small Numbers From Tunneling Between Brane Throats

    Energy Technology Data Exchange (ETDEWEB)

    Kachru, Shamit

    2001-07-25

    Generic classes of string compactifications include ''brane throats'' emanating from the compact dimensions and separated by effective potential barriers raised by the background gravitational fields. The interaction of observers inside different throats occurs via tunneling and is consequently weak. This provides a new mechanism for generating small numbers in Nature. We apply it to the hierarchy problem, where supersymmetry breaking near the unification scale causes TeV sparticle masses inside the standard model throat. We also design naturally long-lived cold dark matter which decays within a Hubble time to the approximate conformal matter of a long throat. This may soften structure formation at galactic scales and raises the possibility that much of the dark matter of the universe is conformal matter. Finally, the tunneling rate shows that the coupling between throats, mediated by bulk modes, is stronger than a naive application of holography suggests.

  1. Tunneling progress on the Yucca Mountain Project

    International Nuclear Information System (INIS)

    Hansmire, W.H.; Munzer, R.J.

    1996-01-01

    The current status of tunneling progress on the Yucca Mountain Project (YMP) is presented in this paper. The Exploratory Studies Facility (ESF), a key part of the YMP, has been long in development and construction is ongoing. This is a progress report on the tunneling aspects of the ESF as of January 1, 1996. For purposes of discussion in this summary, the tunneling has progressed in four general phases. The paper describes: tunneling in jointed rock under low stress; tunneling through the Bow Ridge Fault and soft rock; tunneling through the Imbricate Fault Zone; and Tunneling into the candidate repository formation

  2. Moisture Transport Through Sprayed Concrete Tunnel Linings

    Science.gov (United States)

    Holter, Karl Gunnar; Geving, Stig

    2016-01-01

    Waterproofing of permanent sprayed concrete tunnel linings with sprayed membranes in a continuous sandwich structure has been attempted since 2000 and has seen increased use in some countries. The main function of a sprayed membrane from a waterproofing perspective is to provide crack bridging and hence prevent flow of liquid water into the tunnel through cracks and imperfections in the concrete material. However, moisture can migrate through the concrete and EVA-based membrane materials by capillary and vapor diffusion mechanisms. These moisture transport mechanisms can have an influence on the degree of saturation, and may influence the pore pressures in the concrete material as well as risk of freeze-thaw damage of the concrete and membrane. The paper describes a detailed study of moisture transport material parameters, moisture condition in tunnel linings and climatic conditions tunnels in hard rock in Norway. These data have been included in a hygrothermal simulation model in the software WUFI for moisture transport to substantiate moisture transport and long-term effects on saturation of the concrete and membrane material. The findings suggest that EVA-based membranes exhibit significant water absorption and vapor transport properties although they are impermeable to liquid water flow. State-of-the-art sprayed concrete material applied with the wet mix method exhibits very low hydraulic conductivities, lower than 10-14 m/s, thus saturated conductive water flow is a very unlikely dominant transport mechanism. Moisture transport through the lining structure by capillary flow and vapor diffusion are calculated to approximately 3 cm3/m2 per day for lining thicknesses in the range of 25-35 cm and seasonal Nordic climate variations. The calculated moisture contents in the tunnel linings from the hygrothermal simulations are largely in agreement with the measured moisture contents in the tunnel linings. The findings also indicate that the concrete material exhibits

  3. Destructive quantum interference in spin tunneling problems

    OpenAIRE

    von Delft, Jan; Henley, Christopher L.

    1992-01-01

    In some spin tunneling problems, there are several different but symmetry-related tunneling paths that connect the same initial and final configurations. The topological phase factors of the corresponding tunneling amplitudes can lead to destructive interference between the different paths, so that the total tunneling amplitude is zero. In the study of tunneling between different ground state configurations of the Kagom\\'{e}-lattice quantum Heisenberg antiferromagnet, this occurs when the spi...

  4. Free Surface Water Tunnel (FSWT)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: The Free Surface Water Tunnel consists of the intake plenum, the test section and the exit plenum. The intake plenum starts with a perforated pipe that...

  5. Scanning Tunneling Microscopy - image interpretation

    International Nuclear Information System (INIS)

    Maca, F.

    1998-01-01

    The basic ideas of image interpretation in Scanning Tunneling Microscopy are presented using simple quantum-mechanical models and supplied with examples of successful application. The importance is stressed of a correct interpretation of this brilliant experimental surface technique

  6. Flatback airfoil wind tunnel experiment.

    Energy Technology Data Exchange (ETDEWEB)

    Mayda, Edward A. (University of California, Davis, CA); van Dam, C.P. (University of California, Davis, CA); Chao, David D. (University of California, Davis, CA); Berg, Dale E.

    2008-04-01

    A computational fluid dynamics study of thick wind turbine section shapes in the test section of the UC Davis wind tunnel at a chord Reynolds number of one million is presented. The goals of this study are to validate standard wind tunnel wall corrections for high solid blockage conditions and to reaffirm the favorable effect of a blunt trailing edge or flatback on the performance characteristics of a representative thick airfoil shape prior to building the wind tunnel models and conducting the experiment. The numerical simulations prove the standard wind tunnel corrections to be largely valid for the proposed test of 40% maximum thickness to chord ratio airfoils at a solid blockage ratio of 10%. Comparison of the computed lift characteristics of a sharp trailing edge baseline airfoil and derived flatback airfoils reaffirms the earlier observed trend of reduced sensitivity to surface contamination with increasing trailing edge thickness.

  7. CEBAF: Injector tunnel in action

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    On 28 October, a 100 kV DC electron beam was generated in the injector tunnel at the Continuous Electron Beam Accelerator Facility (CEBAF) being constructed at Newport News, Virginia. In this first tunnel operation, the beam was transported from the electron gun via the room-temperature section to the injector's first superconducting section (5 MeV). The gun and beam steering subsystems behaved as designed, under control from the main control centre

  8. Quantum resonances in physical tunneling

    International Nuclear Information System (INIS)

    Nieto, M.M.; Truax, D.R.

    1985-01-01

    It has recently been emphasized that the probability of quantum tunneling is a critical function of the shape of the potential. Applying this observation to physical systems, we point out that in principal information on potential surfaces can be obtained by studying tunneling rates. This is especially true in cases where only spectral data is known, since many potentials yield the same spectrum. 13 refs., 10 figs., 1 tab

  9. Nonlinear dynamic failure process of tunnel-fault system in response to strong seismic event

    Science.gov (United States)

    Yang, Zhihua; Lan, Hengxing; Zhang, Yongshuang; Gao, Xing; Li, Langping

    2013-03-01

    Strong earthquakes and faults have significant effect on the stability capability of underground tunnel structures. This study used a 3-Dimensional Discrete Element model and the real records of ground motion in the Wenchuan earthquake to investigate the dynamic response of tunnel-fault system. The typical tunnel-fault system was composed of one planned railway tunnel and one seismically active fault. The discrete numerical model was prudentially calibrated by means of the comparison between the field survey and numerical results of ground motion. It was then used to examine the detailed quantitative information on the dynamic response characteristics of tunnel-fault system, including stress distribution, strain, vibration velocity and tunnel failure process. The intensive tunnel-fault interaction during seismic loading induces the dramatic stress redistribution and stress concentration in the intersection of tunnel and fault. The tunnel-fault system behavior is characterized by the complicated nonlinear dynamic failure process in response to a real strong seismic event. It can be qualitatively divided into 5 main stages in terms of its stress, strain and rupturing behaviors: (1) strain localization, (2) rupture initiation, (3) rupture acceleration, (4) spontaneous rupture growth and (5) stabilization. This study provides the insight into the further stability estimation of underground tunnel structures under the combined effect of strong earthquakes and faults.

  10. Origin of the water drained by the tunnel Graton

    International Nuclear Information System (INIS)

    Plata B, A.

    1992-12-01

    The research of the origin of the water drained by the Graton tunnel was attempted using isotope techniques. During the period of studies (April 1989-October 1992), four field work was executed to sample waters for chemistry, stable isotope and Tritium analysis, an to inject tracers and verify the possible infiltration from the Rimac and Blanco rivers to the tunnel. The results of the stable isotope analysis show that the water drained by the Graton tunnel comes from a basin around 300 meters above the average altitude of the basin where the Graton is located. The Tritium analysis show that the water is relatively modern. Using the model of total mixing, the residence times of the water drained at the km 0.5 and 2.5 are in the order to 45 years. The conductivities of the water of the tunnel is higher than the Rimac river ones because the influence of mine water. The chemical analysis of the water sampled at the downstream end of the tunnel, show that the conservative ions of the water kept almost constant during more than two years. The results of the work with artificial tracer show that there is no significant leakage from the Rimac and Blanco rivers to the Graton tunnel. So far, it can be concluded as a preliminary approach that the Graton tunnel drains relatively modern water originated in another basin. The hydrodynamics of the area of study seems to include a large storage on underground water in the system. The topography, geology and isotopic composition of the water samples, points to the upper Mantaro river basin as the possible source of part of the water drained by the Graton tunnel. (authors). 20 p. 2 figs., 7 ills., 4 tabs

  11. Numerical simulation of pollutant dispersion in urban roadway tunnels

    Directory of Open Access Journals (Sweden)

    Jingliang Dong

    2017-03-01

    Full Text Available Vehicular toxic emissions can easily contaminate the air quality of the enclosed tunnel environment, especially during rush hours with traffic jam events or low vehicle speeds, which poses serious health hazards to road utilizers. The piston effect generated by moving vehicles was normally considered adequate to discharge vitiated air out of short tunnel based on a typical driving speed. However, complex traffic conditions may yield unexpected consequences on in-tunnel air quality levels. This study numerically investigated the CO2 concentration to identify the in-tunnel pollutant dispersion under three traffic conditions including severe traffic congestion and traffic flow with low vehicle speeds. Fan conditions were considered to model the influence of mechanical winds on pollutant dispersion and comparison with vehicular piston effect was also performed. The results revealed elevated pollutant concentration regions were found at the vicinity of near-ground region and tunnel downstream. The vehicular piston effect can sufficiently remove the in-tunnel vehicular emissions when vehicles travel at relatively higher speed. However, pollutant accumulation occurs when vehicles are idling or moving at slow speed. Compared with traffic piston effect at high travelling speed, the mechanical ventilation of ceiling mounted fans only generate a limited contribution to the removal of emissions.

  12. Supervision of tunnelling constructions and software used for their evaluation

    Science.gov (United States)

    Caravanas, Aristotelis; Hilar, Matous

    2017-09-01

    Supervision is a common instrument for controlling constructions of tunnels. In order to suit relevant project’s purposes a supervision procedure is modified by local conditions, habits, codes and ways of allocating of a particular tunnelling project. The duties of tunnel supervision are specified in an agreement with the client and they can include a wide range of activities. On large scale tunnelling projects the supervision tasks are performed by a high number of people of different professions. Teamwork, smooth communication and coordination are required in order to successfully fulfil supervision tasks. The efficiency and quality of tunnel supervision work are enhanced when specialized software applications are used. Such applications should allow on-line data management and the prompt evaluation, reporting and sharing of relevant construction information and other aspects. The client is provided with an as-built database that contains all the relevant information related to a construction process, which is a valuable tool for the claim management as well as for the evaluation of structure defects that can occur in the future. As a result, the level of risks related to tunnel constructions is decreased.

  13. The effect of a twin tunnel on the propagation of ground-borne vibration from an underground railway

    Science.gov (United States)

    Kuo, K. A.; Hunt, H. E. M.; Hussein, M. F. M.

    2011-12-01

    Accurate predictions of ground-borne vibration levels in the vicinity of an underground railway are greatly sought after in modern urban centres. Yet the complexity involved in simulating the underground environment means that it is necessary to make simplifying assumptions about this system. One such commonly made assumption is to ignore the effects of neighbouring tunnels, despite the fact that many underground railway lines consist of twin-bored tunnels, one for the outbound direction and one for the inbound direction. This paper presents a unique model for two tunnels embedded in a homogeneous, elastic fullspace. Each of these tunnels is subject to both known, dynamic train forces and dynamic cavity forces. The net forces acting on the tunnels are written as the sum of those tractions acting on the invert of a single tunnel, and those tractions that represent the motion induced by the neighbouring tunnel. By apportioning the tractions in this way, the vibration response of a two-tunnel system is written as a linear combination of displacement fields produced by a single-tunnel system. Using Fourier decomposition, forces are partitioned into symmetric and antisymmetric modenumber components to minimise computation times. The significance of the interactions between two tunnels is quantified by calculating the insertion gains, in both the vertical and horizontal directions, that result from the existence of a second tunnel. The insertion-gain results are shown to be localised and highly dependent on frequency, tunnel orientation and tunnel thickness. At some locations, the magnitude of these insertion gains is greater than 20 dB. This demonstrates that a high degree of inaccuracy exists in any surface vibration prediction model that includes only one of the two tunnels. This novel two-tunnel solution represents a significant contribution to the existing body of research into vibration from underground railways, as it shows that the second tunnel has a significant

  14. Electric and VLF-MT survey of Tegatayama tunnel; Tegatayama tunnel no denki tansa oyobi VLF tansa

    Energy Technology Data Exchange (ETDEWEB)

    Nishitani, T. [Akita University, Akita (Japan). Mining College

    1997-05-27

    To survey the structure at the depth between 20 and 30 m, field tests were conducted by means of vertical electric and VFL-MT (magnetotelluric) survey. Tegatayama tunnel has a total length of 276 m, width of 7.5 m, and height of 4.7 m, and the depth from the surface is about 28 m near the top of mountain. Near the tunnel, the thickness of surface soil is about 60 cm, which consists of clay soil including soft mudstone gravel. It was found that terrace deposit is distributed up to the depth of 8 m, and that mudstone is distributed below the depth of 8 m. Weighted four-electrode method was adopted for the vertical electrical survey. Measurements were conducted at the immediately above the tunnel, 10 m apart from the center of tunnel in the right and left, and 20 m apart from the center in the east. For the VLF-MT method, component of frequency 22.2 kHz was used. As a result of the tests, it was difficult to illustrate the existence of tunnel from the vertical electrical survey only at one point. Feature of the tunnel could be well illustrated by means of the VLF-MT method. 3 refs., 9 figs.

  15. Tunneling and Transport in Nanowires

    International Nuclear Information System (INIS)

    Goldman, Allen M.

    2016-01-01

    The goal of this program was to study new physical phenomena that might be relevant to the performance of conductive devices and circuits of the smallest realizable feature sizes possible using physical rather than biological techniques. Although the initial scientific work supported involved the use of scanning tunneling microscopy and spectroscopy to ascertain the statistics of the energy level distribution of randomly sized and randomly shaped quantum dots, or nano-crystals, the main focus was on the investigation of selected properties, including superconductivity, of conducting and superconducting nanowires prepared using electron-beam-lithography. We discovered a magnetic-field-restoration of superconductivity in out-of-equilibrium nanowires driven resistive by current. This phenomenon was explained by the existence of a state in which dissipation coexisted with nonvanishing superconducting order. We also produced ultra-small superconducting loops to study a predicted anomalous fluxoid quantization, but instead, found a magnetic-field-dependent, high-resistance state, rather than superconductivity. Finally, we developed a simple and controllable nanowire in an induced charged layer near the surface of a masked single-crystal insulator, SrTiO 3 . The layer was induced using an electric double layer transistor employing an ionic liquid (IL). The transport properties of the induced nanowire resembled those of collective electronic transport through an array of quantum dots.

  16. Tunneling and Transport in Nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, Allen M. [Univ. of Minnesota, Minneapolis, MN (United States)

    2016-08-16

    The goal of this program was to study new physical phenomena that might be relevant to the performance of conductive devices and circuits of the smallest realizable feature sizes possible using physical rather than biological techniques. Although the initial scientific work supported involved the use of scanning tunneling microscopy and spectroscopy to ascertain the statistics of the energy level distribution of randomly sized and randomly shaped quantum dots, or nano-crystals, the main focus was on the investigation of selected properties, including superconductivity, of conducting and superconducting nanowires prepared using electron-beam-lithography. We discovered a magnetic-field-restoration of superconductivity in out-of-equilibrium nanowires driven resistive by current. This phenomenon was explained by the existence of a state in which dissipation coexisted with nonvanishing superconducting order. We also produced ultra-small superconducting loops to study a predicted anomalous fluxoid quantization, but instead, found a magnetic-field-dependent, high-resistance state, rather than superconductivity. Finally, we developed a simple and controllable nanowire in an induced charged layer near the surface of a masked single-crystal insulator, SrTiO3. The layer was induced using an electric double layer transistor employing an ionic liquid (IL). The transport properties of the induced nanowire resembled those of collective electronic transport through an array of quantum dots.

  17. Electronic noise of superconducting tunnel junction detectors

    International Nuclear Information System (INIS)

    Jochum, J.; Kraus, H.; Gutsche, M.; Kemmather, B.; Feilitzsch, F. v.; Moessbauer, R.L.

    1994-01-01

    The optimal signal to noise ratio for detectors based on superconducting tunnel junctions is calculated and compared for the cases of a detector consisting of one single tunnel junction, as well as of series and of parallel connections of such tunnel junctions. The influence of 1 / f noise and its dependence on the dynamical resistance of tunnel junctions is discussed quantitatively. A single tunnel junction yields the minimum equivalent noise charge. Such a tunnel junction exhibits the best signal to noise ratio if the signal charge is independent of detector size. In case, signal charge increases with detector size, a parallel or a series connection of tunnel junctions would provide the optimum signal to noise ratio. The equivalent noise charge and the respective signal to noise ratio are deduced as functions of tunnel junction parameters such as tunneling time, quasiparticle lifetime, etc. (orig.)

  18. The time of discrete spectrum identical particles tunneling at their simultaneous passing over rectangular quantum barrier

    International Nuclear Information System (INIS)

    Martsenyuk, L.S.

    2010-01-01

    Research of influence of exchange interaction of identical particles for the time of their simultaneous tunneling through a rectangular quantum barrier is lead. The account of identity leads to necessity of symmetrisation of wave function owing to what in the formula describing interaction of two particles, arises an additional element. In result the parameters of tunneling, including time of tunneling change. Time of tunneling is calculated from the formula received in work from the size of exchange interaction of two particles simultaneously crossing a rectangular quantum barrier.

  19. Simulating Small-Scale Experiments of In-Tunnel Airblast Using STUN and ALE3D

    Energy Technology Data Exchange (ETDEWEB)

    Neuscamman, Stephanie [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, Lewis [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Schebler, Gregory [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McMichael, Larry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glascoe, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-09-12

    This report details continuing validation efforts for the Sphere and Tunnel (STUN) and ALE3D codes. STUN has been validated previously for blast propagation through tunnels using several sets of experimental data with varying charge sizes and tunnel configurations, including the MARVEL nuclear driven shock tube experiment (Glenn, 2001). The DHS-funded STUNTool version is compared to experimental data and the LLNL ALE3D hydrocode. In this particular study, we compare the performance of the STUN and ALE3D codes in modeling an in-tunnel airblast to experimental results obtained by Lunderman and Ohrt in a series of small-scale high explosive experiments (1997).

  20. Typical Underwater Tunnels in the Mainland of China and Related Tunneling Technologies

    Directory of Open Access Journals (Sweden)

    Kairong Hong

    2017-12-01

    Full Text Available In the past decades, many underwater tunnels have been constructed in the mainland of China, and great progress has been made in related tunneling technologies. This paper presents the history and state of the art of underwater tunnels in the mainland of China in terms of shield-bored tunnels, drill-and-blast tunnels, and immersed tunnels. Typical underwater tunnels of these types in the mainland of China are described, along with innovative technologies regarding comprehensive geological prediction, grouting-based consolidation, the design and construction of large cross-sectional tunnels with shallow cover in weak strata, cutting tool replacement under limited drainage and reduced pressure conditions, the detection and treatment of boulders, the construction of underwater tunnels in areas with high seismic intensity, and the treatment of serious sedimentation in a foundation channel of immersed tunnels. Some suggestions are made regarding the three potential great strait-crossing tunnels—the Qiongzhou Strait-Crossing Tunnel, Bohai Strait-Crossing Tunnel, and Taiwan Strait-Crossing Tunnel—and issues related to these great strait-crossing tunnels that need further study are proposed. Keywords: Underwater tunnel, Strait-crossing tunnel, Shield-bored tunnel, Immersed tunnel, Drill and blast

  1. Superconducting tunnel-junction refrigerator

    International Nuclear Information System (INIS)

    Melton, R.G.; Paterson, J.L.; Kaplan, S.B.

    1980-01-01

    The dc current through an S 1 -S 2 tunnel junction, with Δ 2 greater than Δ 1 , when biased with eV 1 +Δ 2 , will lower the energy in S 1 . This energy reduction will be shared by the phonons and electrons. This device is shown to be analogous to a thermoelectric refrigerator with an effective Peltier coefficient π* approx. Δ 1 /e. Tunneling calculations yield the cooling power P/sub c/, the electrical power P/sub e/ supplied by the bias supply, and the cooling efficiency eta=P/sub c//P/sub e/. The maximum cooling power is obtained for eV= +- (Δ 2 -Δ 1 ) and t 1 =T 1 /T/sub c/1 approx. 0.9. Estimates are made of the temperature difference T 2 -T 1 achievable in Al-Pb and Sn-Pb junctions with an Al 2 O 3 tunneling barrier. The performance of this device is shown to yield a maximum cooling efficiency eta approx. = Δ 1 /(Δ 2 -Δ 1 ) which can be compared with that available in an ideal Carnot refrigerator of eta=T 1 /(T 2 -T 1 ). The development of a useful tunnel-junction refrigerator requires a tunneling barrier with an effective thermal conductance per unit area several orders of magnitude less than that provided by the A1 2 O 3 barrier in the Al-Pb and Sn-Pb systems

  2. TunnelVision: LHC Tunnel Photogrammetry System for Structural Monitoring

    CERN Document Server

    Fallas, William

    2014-01-01

    In this document an algorithm to detect deformations in the LHC Tunnel of CERN is presented. It is based on two images, one represents the ideal state of the tunnel and the other one the actual state. To find the differences between both, the algorithm is divided in three steps. First, an image enhancement is applied to make easier the detection. Second, two different approaches to reduce noise are applied to one or both images. And third, it is defined a group of characteristics about the type of deformation desired to detect. Finally, the conclusions show the effectiveness of the algorithm in the experimental results.

  3. Outcome of Radiologically Placed Tunneled Haemodialysis Catheters

    International Nuclear Information System (INIS)

    Sayani, R.; Anwar, M.; Haq, T.U.; Qamari, N.A.; Bilal, M.A.

    2013-01-01

    Objective: To study the outcome of radiologically placed double lumen tunneled haemodialysis catheters for the management of renal failure. Study Design: Case series. Place and Duration of Study: Interventional Suite of Radiology Department at the Aga Khan University Hospital, Karachi, from April 2010 to June 2011. Methodology: All consecutive patients who were referred to the department of radiology by the nephrologists for double lumen tunneled haemodialysis catheter (Permacath) placement during the study period were included. Patients with septicemia, those for whom follow-up was not available, those coming for catheter exchange or who died due to a noncatheter related condition were excluded. A radio-opaque, soft silicone double lumen catheter was inserted through a subcutaneous tunnel created over the anterior chest wall. The catheter tip was placed in the right atrium via the internal jugular vein. Ultrasound guidance was used for initial venous puncture. The rest of the procedure was carried out under fluoroscopic guidance. Technical success, catheter related bacteremia rates, adequacy of dialysis, patency, and adverse events were analyzed. Results: Overall 88 tunneled haemodialysis catheters were placed in 87 patients. Patients were followed-up for duration of 1 - 307 days with mean follow-up period of 4 months. Immediate technical success was 100%. The procedural complication rate was 5.6% (5 catheters). Eight patients died during the study period, seven from causes unrelated to the procedure. One patient died due to septicemia secondary to catheter related infection. Of the remaining 69 patients, 50 (72.4%) predominantly had uneventful course during the study period. Twelve patients developed infection (17.3%); two were successfully treated conservatively while in 10 patients catheter had to be removed. Seven catheters (10.1%) failed due to mechanical problems. In 3 patients the internal jugular veins got partially thrombosed. One catheter was

  4. Studies of Au/SAMs/PEDOT-PSS/Au tunnel junctions

    Science.gov (United States)

    Sun, Nan; Lieberman, Marya; Ruggiero, Steven

    2008-03-01

    We report on tunneling through thin organic films. Junctions of the form: Au/SAMs/Polymer/Au were prepared on electronic-grade Si substrates with Self-Assembled Monolayers (SAMs) including octanedithiol (HS-C8H16-SH) and mercaptohexadecanoic (HS-C15H30-COOH). A transitional conducting polymer film PEDOT-PSS was spun on to the SAMs layer, and junctions were completed with a gold film. X-ray photoelectron spectroscopy (XPS) was employed to monitor the quality of the SAMs films. The electron tunneling properties including dI/dV and d^2I/dV^2 versus bias for the SAMs are discussed.

  5. Static design of steel-concrete lining for traffic tunnels

    Science.gov (United States)

    Vojtasik, Karel; Mohyla, Marek; Hrubesova, Eva

    2017-09-01

    Article summarizes the results of research focused on the structural design of traffic tunnel linings that have been achieved in the framework of a research project TE01020168 that supports The Technology Agency of Czech Republic. This research aim is to find and develop a process for design structure parameters of tunnel linings. These are now mostly build up by a shotcrete technology. The shotcrete is commonly endorsed either with steel girders or steel fibres. Since the installation a lining structure is loaded while strength and deformational parameters of shotcrete start to rise till the setting time elapses. That’s reason why conventional approaches of reinforced concrete are not suitable. As well as there are other circumstances to step in shown in this article. Problem is solved by 3D analysis using numerical model that takes into account all the significant features of a tunnel lining construction process inclusive the interaction between lining structure with rock massive. Analysis output is a view into development of stress-strain state in respective construction parts of tunnel lining the whole structure around, including impact on stability of rock massive. The proposed method comprises all features involved in tunnel fabrication including geotechnics and construction technologies.

  6. Enhancement of Cross-Borehole Pulse Radar Signature on a Partially Water-Filled Tunnel

    Directory of Open Access Journals (Sweden)

    Ji-Hyun Jung

    2014-01-01

    Full Text Available Cross-borehole pulse radar has been employed to detect a deeply located empty tunnel. In this paper, effects of underground water collected in the bottom of an empty tunnel on cross-borehole pulse radar signatures are analyzed numerically. B-scan images, stacks of received pulses, are calculated by applying the finite-difference time-domain (FDTD method for 6 different heights of water from the bottom to the half height inside an empty tunnel. The most important features of an empty tunnel, the fastest time of peak (TOP and time of arrival (TOA extracted from the B-scan images, are slowed considerably depending on the increased height of water inside the tunnel. To compensate the weak TOP like that of an empty tunnel, a relation curve is formulated only utilizing measurable parameters of the fastest TOP and the fastest TOA. Then, a unified curve including the effects of two granites with the low and high dielectric properties is derived to cover widely varied dielectric properties of underground rocks. Based on the fastest TOP of an empty tunnel, the average difference between the fastest TOP of an empty tunnel and that of a partially water-filled tunnel decreases from 22.92% to 2.59% after enhancement.

  7. Probing electronic interactions using electron tunneling

    Indian Academy of Sciences (India)

    pratap

    The scanning tunneling microscope: Principle d. eI. Tunneling Current. Topography by tracking current: Constant height mode. Tracking the height: Constant current mode. NbSe. 2 single crystal. (Grown by P. Shirage and A. Thamizhavel) ...

  8. Proposal for Marshmallow Tunnel Stemming Study

    Energy Technology Data Exchange (ETDEWEB)

    1962-01-01

    Discussion of findings after the shot in the tunnel and instructions for a deeper drilling below the tunnel using radiation probes to help define the cavity shape and documentary photography of the findings.

  9. Quantum mechanical tunneling in chemical physics

    CERN Document Server

    Nakamura, Hiroki

    2016-01-01

    Quantum mechanical tunneling plays important roles in a wide range of natural sciences, from nuclear and solid-state physics to proton transfer and chemical reactions in chemistry and biology. Responding to the need for further understanding of multidimensional tunneling, the authors have recently developed practical methods that can be applied to multidimensional systems. Quantum Mechanical Tunneling in Chemical Physics presents basic theories, as well as original ones developed by the authors. It also provides methodologies and numerical applications to real molecular systems. The book offers information so readers can understand the basic concepts and dynamics of multidimensional tunneling phenomena and use the described methods for various molecular spectroscopy and chemical dynamics problems. The text focuses on three tunneling phenomena: (1) energy splitting, or tunneling splitting, in symmetric double well potential, (2) decay of metastable state through tunneling, and (3) tunneling effects in chemical...

  10. Resonant tunneling diode oscillators for optical communications

    Science.gov (United States)

    Watson, Scott; Zhang, Weikang; Wang, Jue; Al-Khalidi, Abdullah; Cantu, Horacio; Figueiredo, Jose; Wasige, Edward; Kelly, Anthony E.

    2017-08-01

    The ability to use resonant tunneling diodes (RTDs) as both transmitters and receivers is an emerging topic, especially with regards to wireless communications. Successful data transmission has been achieved using electronic RTDs with carrier frequencies exceeding 0.3 THz. Specific optical-based RTDs, which act as photodetectors, have been developed by adjusting the device structure to include a light absorption layer and small optical windows on top of the device to allow direct optical access. This also allows the optical signal to directly modulate the RTD oscillation. Both types of RTD oscillators will allow for seamless integration of high frequency radio and optical fiber networks.

  11. Spin tunnelling in mesoscopic systems

    Science.gov (United States)

    Garg, Anupam

    2001-02-01

    We study spin tunnelling in molecular magnets as an instance of a mesoscopic phenomenon, with special emphasis on the molecule Fe8. We show that the tunnel splitting between various pairs of Zeeman levels in this molecule oscillates as a function of applied magnetic field, vanishing completely at special points in the space of magnetic fields, known as diabolical points. This phenomena is explained in terms of two approaches, one based on spin-coherent-state path integrals, and the other on a generalization of the phase integral (or WKB) method to difference equations. Explicit formulas for the diabolical points are obtained for a model Hamiltonian.

  12. Tunneling field effect transistor technology

    CERN Document Server

    Chan, Mansun

    2016-01-01

    This book provides a single-source reference to the state-of-the art in tunneling field effect transistors (TFETs). Readers will learn the TFETs physics from advanced atomistic simulations, the TFETs fabrication process and the important roles that TFETs will play in enabling integrated circuit designs for power efficiency. · Provides comprehensive reference to tunneling field effect transistors (TFETs); · Covers all aspects of TFETs, from device process to modeling and applications; · Enables design of power-efficient integrated circuits, with low power consumption TFETs.

  13. Watertightness of concrete tunnel structures

    OpenAIRE

    Glerum, A.

    1982-01-01

    The Netherlands are situated in the delta. of the rivers Rhine, Meuse and Scheldt. Therefore the ground mainly consists.of sediments, such as sand, clay and silt. In certain regions peat layers of varying thickness are found. The high permeability of some of these materials and the fact that the groundwater table is generally only 1 m below ground level, make an adequate watertightness one of the main features of tunnel engineering in the Netherlands. Tunnels in Holland are both of the immers...

  14. Spin-dependent tunnelling in magnetic tunnel junctions

    International Nuclear Information System (INIS)

    Tsymbal, Evgeny Y; Mryasov, Oleg N; LeClair, Patrick R

    2003-01-01

    The phenomenon of electron tunnelling has been known since the advent of quantum mechanics, but continues to enrich our understanding of many fields of physics, as well as creating sub-fields on its own. Spin-dependent tunnelling (SDT) in magnetic tunnel junctions (MTJs) has recently aroused enormous interest and has developed in a vigorous field of research. The large tunnelling magnetoresistance (TMR) observed in MTJs garnered much attention due to possible applications in non-volatile random-access memories and next-generation magnetic field sensors. This led to a number of fundamental questions regarding the phenomenon of SDT. In this review article we present an overview of this field of research. We discuss various factors that control the spin polarization and magnetoresistance in MTJs. Starting from early experiments on SDT and their interpretation, we consider thereafter recent experiments and models which highlight the role of the electronic structure of the ferromagnets, the insulating layer, and the ferromagnet/insulator interfaces. We also discuss the role of disorder in the barrier and in the ferromagnetic electrodes and their influence on TMR. (topical review)

  15. Quasi-bound states, resonance tunnelling, and tunnelling times ...

    Indian Academy of Sciences (India)

    scattering and decay of unstable nuclei via alpha decay, proton emission etc. as evident from refs [14–19]. A detailed procedure exists for the study of such states in ...... for the case of transmission across equispaced multiple barriers generating well-separated QB states. 3. The variation of total tunnelling time Tq shows ...

  16. Tunneling in high-K isomeric decays

    CERN Document Server

    Shizuma, T; Shimizu, Y R

    2002-01-01

    We have systematically investigated highly-K-forbidden transitions observed in the Hf, W and Os region, using the gamma-tunneling model in which low-K and high-k states interact through a process of quantum tunneling. The measured hindrance factors are compared with the values calculated using the gamma-tunneling model. Isotope dependences of gamma-tunneling probabilities particularly for neutron-rich nuclei and the relation to stimulated decays of isomers are discussed. (author)

  17. Materials Handling for Urban Tunneling in Rock

    Science.gov (United States)

    1979-01-01

    An examination of prior forecasts of tunnel construction provides an estimate of 2.4 million feet of rock tunnel to be constructed during the 1976-2000 period. Tunnel projects for the near term (1980+) and far term (1990+) periods are defined for stu...

  18. 75 FR 42643 - National Tunnel Inspection Standards

    Science.gov (United States)

    2010-07-22

    ... title 23 Federal funds that are located on public roads and tunnels on Federal-aid highways. The agency... the fatal July 2006 suspended ceiling collapse in the Central Artery Tunnel in Boston, [[Page 42644... located on public roads and tunnels on Federal-aid highways. The NTIS are needed to ensure that all...

  19. Thermal effects influencing measurements in a supersonic blowdown wind tunnel

    Directory of Open Access Journals (Sweden)

    Vuković Đorđe S.

    2016-01-01

    Full Text Available During a supersonic run of a blowdown wind tunnel, temperature of air in the test section drops which can affect planned measurements. Adverse thermal effects include variations of the Mach and Reynolds numbers, variation of airspeed, condensation of moisture on the model, change of characteristics of the instrumentation in the model, et cetera. Available data on thermal effects on instrumentation are pertaining primarily to long-run-duration wind tunnel facilities. In order to characterize such influences on instrumentation in the models, in short-run-duration blowdown wind tunnels, temperature measurements were made in the wing-panel-balance and main-balance spaces of two wind tunnel models tested in the T-38 wind tunnel. The measurements showed that model-interior temperature in a run increased at the beginning of the run, followed by a slower drop and, at the end of the run, by a large temperature drop. Panel-force balance was affected much more than the main balance. Ways of reducing the unwelcome thermal effects by instrumentation design and test planning are discussed.

  20. Fan array wind tunnel: a multifunctional, complex environmental flow manipulator

    Science.gov (United States)

    Dougherty, Christopher; Veismann, Marcel; Gharib, Morteza

    2017-11-01

    The recent emergence of small unmanned aerial vehicles (UAVs) has reshaped the aerospace testing environment. Traditional closed-loop wind tunnels are not particularly suited nor easily retrofit to take advantage of these coordinated, controls-based rotorcraft. As such, a highly configurable, novel wind tunnel aimed at addressing the unmet technical challenges associated with single or formation flight performance of autonomous drone systems is presented. The open-loop fan array wind tunnel features 1296 individually controllable DC fans arranged in a 2.88m x 2.88m array. The fan array can operate with and without a tunnel enclosure and is able to rotate between horizontal and vertical testing configurations. In addition to standard variable speed uniform flow, the fan array can generate both unsteady and shear flows. Through the aid of smaller side fan array units, vortex flows are also possible. Conceptual design, fabrication, and validation of the tunnel performance will be presented, including theoretical and computational predictions of flow speed and turbulence intensity. Validation of these parameters is accomplished through standard pitot-static and hot-wire techniques. Particle image velocimetry (PIV) of various complex flows will also be shown. This material is based upon work supported by the Center for Autonomous Systems and Technologies (CAST) at the Graduate Aerospace Laboratories of the California Institute of Technology (GALCIT).

  1. Phonon-assisted Zener tunneling in a cylindrical nanowire transistor

    Science.gov (United States)

    Carrillo-Nuñez, H.; Magnus, Wim; Vandenberghe, William G.; Sorée, Bart; Peeters, François M.

    2013-05-01

    The tunneling current has been computed for a cylindrical nanowire tunneling field-effect transistor (TFET) with an all-round gate that covers the source region. Being the underlying mechanism, band-to-band tunneling, mediated by electron-phonon interaction, is pronouncedly affected by carrier confinement in the radial direction and, therefore, involves the self-consistent solution of the Schrödinger and Poisson equations. The latter has been accomplished by exploiting a non-linear variational principle within the framework of the modified local density approximation taking into account the nonparabolicity of both the valence band and conduction band in relatively thick wires. Moreover, while the effective-mass approximation might still provide a reasonable description of the conduction band in relatively thick wires, we have found that the nonparabolicity of the valence band needs to be included. As a major conclusion, it is observed that confinement effects in nanowire tunneling field-effect transistors have a stronger impact on the onset voltage of the tunneling current in comparison with planar TFETs. On the other hand, the value of the onset voltage is found to be overestimated when the valence band nonparabolicity is ignored.

  2. Tunneling on the Yucca Mountain Project: Progress and lessons learned

    International Nuclear Information System (INIS)

    Hansmire, W.H.; Rogers, D.J.; Wightman, W.D.

    1996-01-01

    The Yucca Mountain Site Characterization Project is the US's effort to confirm the technical acceptability of Yucca Mountain as a repository for high-level nuclear waste. A key part of the site characterization project is the construction of a 7.8-km-long, 7.6-m-diameter tunnel for in-depth geologic and other scientific investigations. The work is governed in varying degrees by the special requirements for nuclear quality assurance, which imposes uncommon and often stringent limitations on the materials which can be used in construction, the tunneling methods and procedures used, and record-keeping for many activities. This paper presents the current status of what has been learned, how construction has adapted to meet the requirements, and how the requirements were interpreted in a mitigating way to meet the legal obligations, yet build the tunnel as rapidly as possible. With regard to design methodologies and the realities of tunnel construction, ground support with a shielded Tunnel Boring Machine is discussed. Notable lessons learned include the need for broad design analyses for a wide variety of conditions and how construction procedures affect ground support

  3. Contrastwaarnemingen in tunnels : een meetmethode.

    NARCIS (Netherlands)

    Schreuder, D.A.

    1994-01-01

    The entrance to a long road tunnel can present itself to an approaching driver as a 'black hole' during the daytime, with no possibility for observing any details. In contrast to traditional symmetrical lighting, counter beam lighting aims the light in the opposite direction to incoming traffic.

  4. Travelling inside the SPS tunnel

    CERN Multimedia

    1974-01-01

    The golf cart proved to be a very useful form of transport around the 7 km circumference of the machine. It could carry four passengers and pull light equipment in its trailer. Here Peter Zettwoch is the driver along a mock-up tunnel for installation tests. (see photo 7401011X and Photo Archive 7401018)

  5. Apparent tunneling in chemical reactions

    DEFF Research Database (Denmark)

    Henriksen, Niels Engholm; Hansen, Flemming Yssing; Billing, G. D.

    2000-01-01

    A necessary condition for tunneling in a chemical reaction is that the probability of crossing a barrier is non-zero, when the energy of the reactants is below the potential energy of the barrier. Due to the non-classical nature (i.e, momentum uncertainty) of vibrational states this is, however...

  6. A Seamless Ubiquitous Telehealthcare Tunnel

    Directory of Open Access Journals (Sweden)

    Sao-Jie Chen

    2013-08-01

    Full Text Available Mobile handheld devices are rapidly using to implement healthcare services around the World. Fundamentally, these services utilize telemedicine technologies. A disconnection of a mobile telemedicine system usually results in an interruption, which is embarrassing, and reconnection is necessary during the communication session. In this study, the Stream Control Transmission Protocol (SCTP is adopted to build a stable session tunnel to guarantee seamless switching among heterogeneous wireless communication standards, such as Wi-Fi and 3G. This arrangement means that the telemedicine devices will not be limited by a fixed wireless connection and can switch to a better wireless channel if necessary. The tunnel can transmit plain text, binary data, and video streams. According to the evaluation of the proposed software-based SCTP-Tunnel middleware shown, the performance is lower than anticipated and is slightly slower than a fixed connection. However, the transmission throughput is still acceptable for healthcare professionals in a healthcare enterprise or home care site. It is necessary to build more heterogeneous wireless protocols into the proposed tunnel-switching scheme to support all possible communication protocols. In addition, SCTP is another good choice for promoting communication in telemedicine and healthcare fields.

  7. Spin tunnelling in mesoscopic systems

    Indian Academy of Sciences (India)

    Spin tunnelling; spin path integrals; discrete phase integral method; diabolical points. ... technologies. Our purpose in this article is rather different. The molecular systems have total spin of the order of 10, and magnetocrystalline anisotropies of few tens of Kelvin ...... The point С' is of this new type, and here it may be said to.

  8. Rotational tunnelling spectroscopy with neutrons

    International Nuclear Information System (INIS)

    Carlile, C.J.; Prager, M.

    1993-04-01

    Neutron tunnelling spectroscopy has been a very fruitful field for almost two decades and is still expanding into new areas, both experimentally and theoretically. The development of the topic is reviewed from the theoretical point of view, highlighting new approaches, and selected examples of more recent experimental work are presented. A brief discussion of instrument performance and experimental requirements is given. (author)

  9. Installation in the SPS tunnel

    CERN Multimedia

    1974-01-01

    The SPS tunnel is 6910 m in circumference and has a cross section of 4 m inner diameter. It is situated at an elevation of 400 m above sea level at a depth below the surface varying between 23 and 65 m. Its walls are lined with a concrete shell of about 30 cm thickness. See also 7410043X

  10. Time tunnels meet warped passages

    CERN Multimedia

    Kushner, David

    2006-01-01

    "Just in time for its 40th anniversary, the classic sci-fi television show "The time tunnel" is out on DVD. The conceit is something every engineer can relate to: a pulled plug. Scientists in an underground lab are working on a secret government experiment in time travel. (1 page)

  11. Earth Pressure on Tunnel Crown

    DEFF Research Database (Denmark)

    Andersen, Lars

    Two different analyses have been carried out in order to find the vertical earth pressure, or overburden pressure, at the crown of a tunnel going through a dike. Firstly, a hand calculation is performed using a simple dispersion of the stresses over depth. Secondly, the finite‐element program...

  12. Convulxin induces platelet activation by a tyrosine-kinase-dependent pathway and stimulates tyrosine phosphorylation of platelet proteins, including PLC gamma 2, independently of integrin alpha IIb beta 3.

    Science.gov (United States)

    Francischetti, I M; Ghazaleh, F A; Reis, R A; Carlini, C R; Guimarães, J A

    1998-05-15

    1Convulxin (Cvx) is a well-characterized platelet aggregating glycoprotein isolated from Crotalus durissus terrificus and C. d. cascavella venoms. In the present report we show that Cvx induces tyrosine phosphorylation of human platelet proteins, including phospholipase C-gamma 2 (PLC gamma 2), and also stimulates [3H]arachidonic acid ([3H]AA) mobilization, pleckstrin phosphorylation, and an increase in the cytosolic Ca2+ concentration ([Ca2+]in) due to both Ca2+ entry and internal Ca2+ mobilization. Staurosporine, a potent protein kinase inhibitor, and genistein, a specific inhibitor of protein tyrosine kinases (PTK), were used to evaluate the role of protein tyrosine phosphorylation (PTP) in the signal transduction evoked by Cvx. Staurosporine and genistein inhibited in a dose-dependent manner platelet aggregation induced by Cvx. Both inhibitors significantly blocked to near basal levels breakdown of phosphatidylinositol 4,5-bisphosphate from [myo-2-3H]inositol-labeled platelets and the production of [3H]AA metabolites from [3H]AA-labeled platelets after challenge with Cvx. Cvx provokes an increase in [Ca2+]in in Fura-2-loaded platelets that was abolished by concentrations of staurosporine which also inhibited Cvx-induced platelet aggregation. In addition, Cvx stimulates a rapid increase in tyrosine phosphorylation of human platelets proteins with molecular masses of 40, 72/74, 78/80, 105, 120, and 145 kDa, followed by dephosphorylation. Furthermore, Cvx stimulates a rapid tyrosyl phosphorylation of a 145-kDa molecular mass protein that was identified as PLC gamma 2. PTP induced by Cvx was not inhibited when platelets were stimulated in the presence of indomethacin, apyrase, EDTA, or RGDS peptide. These results indicate that PTP is chronologically proximal to Cvx binding to platelets, and is independent of aggregation or fibrinogen binding to the integrin alpha IIb beta 3. On the other hand, the dephosphorylation step is inhibited by RGDS peptide or EDTA

  13. Theory of single-spin inelastic tunneling spectroscopy.

    Science.gov (United States)

    Fernández-Rossier, J

    2009-06-26

    I show that recent experiments of inelastic scanning tunneling spectroscopy of single and a few magnetic atoms are modeled with a phenomenological spin-assisted tunneling Hamiltonian so that the inelastic dI/dV line shape is related to the spin spectral weight of the magnetic atom. This accounts for the spin selection rules and dI/dV spectra observed experimentally for single Fe and Mn atoms deposited on Cu2N. In the case of chains of Mn atoms it is found necessary to include both first and second-neighbor exchange interactions as well as single-ion anisotropy.

  14. Geotechnical characterization and construction methods for SSC tunnel excavation

    International Nuclear Information System (INIS)

    Nelson, P.P.; Lundin, T.K.

    1990-06-01

    The site for the Superconducting Super Collider (SSC) facility was selected in 1988 after a nationwide proposal competition. The selected site is located in Ellis County, Texas, surrounding the town of Waxahachie which is about 30 miles (48 km) south of the City of Dallas central business district. This paper will describe the geotechnical conditions anticipated for excavation at the SSC site. A general geologic and geomechanical description of the rock present will be followed by a summary of the site-specific conceptual design for the tunneled components of the SSC machine. The Supercollider project will include about 70 miles (113) km of tunnel excavation

  15. TBM tunneling on the Yucca Mountain Project: Proceedings

    International Nuclear Information System (INIS)

    Williamson, G.E.; Gowring, I.M.

    1995-01-01

    The US Department of Energy's (DOE) Yucca Mountain Project (YMP) is a scientific endeavor to determine the suitability of Yucca Mountain for the first long term, high level nuclear waste repository in the United States. Status of this long-term project form the construction perspective is described. A key element is construction of the Exploratory Studies Facility (ESF), which is being excavated with a 7. 6 m(25 ft) diameter tunnel boring machine (TBM). Development of the ESF may include the excavation of over 15 km (9.3 mi) of tunnel varying in size from 3 to 7.6 m(10 to 25 ft). Prior to construction, extensive constructibility reviews were an interactive part of the final design. Intent was to establish a constructible design that met the long-term stability requirements for radiological safety of a future repository while maintaining flexibility for the scientific investigations and acceptable tunneling productivity

  16. 9x15 Low Speed Wind Tunnel Acoustic Improvements

    Science.gov (United States)

    Stark, David; Stephens, David

    2016-01-01

    The 9- by 15-Foot Low Speed Wind Tunnel (9x15 LSWT) at NASA Glenn Research Center was built in 1969 in the return leg of the 8- by 6-Foot Supersonic Wind Tunnel (8x6 SWT). The 8x6 SWT was completed in 1949 and acoustically treated to mitigate community noise issues in 1950. This treatment included the addition of a large muffler downstream of the 8x6 SWT test section and diffuser. The 9x15 LSWT was designed for performance testing of VSTOL aircraft models, but with the addition of the current acoustic treatment in 1986 the tunnel has been used principally for acoustic and performance testing of aircraft propulsions systems. The present document describes an anticipated acoustic upgrade to be completed in 2017.

  17. Fiber coupled ultrafast scanning tunneling microscope

    DEFF Research Database (Denmark)

    Keil, Ulrich Dieter Felix; Jensen, Jacob Riis; Hvam, Jørn Märcher

    1997-01-01

    We report on a scanning tunneling microscope with a photoconductive gate in the tunneling current circuit. The tunneling tip is attached to a coplanar transmission line with an integrated photoconductive switch. The switch is illuminated through a fiber which is rigidly attached to the switch...... waveguide. The measurements show that the probe works as a transient voltage detector in contact and a capacitively coupled transient field detector in tunneling mode. We do not measure the transient voltage change in the ohmic tunneling current. In this sense, the spatial resolution for propagating...

  18. Tunnel widening in anterior cruciate ligament reconstruction

    DEFF Research Database (Denmark)

    Clatworthy, M G; Annear, P; Bulow, J U

    1999-01-01

    We report a prospective series evaluating the incidence and degree of tunnel widening in a well-matched series of patients receiving a hamstring or patella tendon graft for anterior cruciate ligament (ACL) deficiency. We correlated tunnel widening with clinical factors, knee scores, KT-1000...... in the degree of tunnel widening between the two groups. The mean increase in femoral tunnel area in the hamstring group was 100.4% compared with a decrease of 25% in the patella tendon group (P = hamstring group was 73.9% compared with a decrease of 2.......1% in the patella tendon group (P = hamstring group. Tunnel widening does not correlate with instability...

  19. Nano-ADEPT Aeroloads Wind Tunnel Test

    Science.gov (United States)

    Smith, Brandon; Yount, Bryan; Kruger, Carl; Brivkalns, Chad; Makino, Alberto; Cassell, Alan; Zarchi, Kerry; McDaniel, Ryan; Ross, James; Wercinski, Paul; hide

    2016-01-01

    A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control.

  20. Aespoe HRL. Experiences of blasting of the TASQ tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, Mats [Swebrec, Luleaa (Sweden); Niklasson, Bengt [Skanska Teknik, Stockholm (Sweden); Wilson, Lasse [Skanska Stora Projekt, Stockholm (Sweden); Andersson, Christer; Christiansson, Rolf [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    2004-11-01

    A new tunnel was developed at the Aespoe Hard Rock Laboratory (AHRL) during the spring and summer 2003. The tunnel was specially designed for a rock mechanics experiment, the Aespoe Pillar Stability Experiment (APSE). In this pillar experiment there was a high demand to initiate high in-situ stresses and therefore the tunnel was designed with a large height/ width ratio and with a circular floor. There were high requirements on bore hole precision and of a minimized EDZ (Excavation damaged zone) in the pillar area. This included a maximum borehole deviation of 10 mm/m, a maximum overbreak due to the lookout angle of 0.3 m and an EDZ of 0.3 m. To make a charge control feasible cartridged explosives was prescribed. The initiation was made with Nonel. The last three rounds used electronic initiation to enable studies of possibility to further reduce the EDZ. The collar of the tunnel was very close to installations and shaft and it was very important to avoid fly-rock and vibrations. Special types of stemming were used as well as steel plates and rubber mats. The excavation works was divided in three different phases. The first phase of the tunnel was an ordinary 26 m{sup 2} tunnel. After approximately 30 m a ramp separated the tunnel section into a top heading and a bench, total 33 m{sup 2}. After the last top heading round was excavated and the roof had been reinforced with fibre reinforced shotcrete the bench was taken out with horizontal holes as the third phase. The drilling precision was very good and 95% of all half-pipes fulfilled the demands. The total amount of visible half-pipes in the APSE-tunnel was high and indicated a successful smooth blasting. The EDZ was examined further by cutting slots in the wall and roof. Existing cracks appear very clearly when a dye penetrant is sprayed on the cleaned surface. A typical crack pattern consists of blast cracks, induced cracks (cracks from the distressing caused by blasting) and natural cracks. The maximum crack

  1. Automated Boundary Conditions for Wind Tunnel Simulations

    Science.gov (United States)

    Carlson, Jan-Renee

    2018-01-01

    Computational fluid dynamic (CFD) simulations of models tested in wind tunnels require a high level of fidelity and accuracy particularly for the purposes of CFD validation efforts. Considerable effort is required to ensure the proper characterization of both the physical geometry of the wind tunnel and recreating the correct flow conditions inside the wind tunnel. The typical trial-and-error effort used for determining the boundary condition values for a particular tunnel configuration are time and computer resource intensive. This paper describes a method for calculating and updating the back pressure boundary condition in wind tunnel simulations by using a proportional-integral-derivative controller. The controller methodology and equations are discussed, and simulations using the controller to set a tunnel Mach number in the NASA Langley 14- by 22-Foot Subsonic Tunnel are demonstrated.

  2. Spin-polarized tunneling through a ferromagnetic insulator

    NARCIS (Netherlands)

    Kok, M.; Kok, M.; Beukers, J.N.; Brinkman, Alexander

    2009-01-01

    The polarization of the tunnel conductance of spin-selective ferromagnetic insulators is modeled, providing a generalized concept of polarization including both the effects of electrode and barrier polarization. The polarization model is extended to take additional non-spin-polarizing insulating

  3. Human behaviour in tunnels: what further steps to take?

    NARCIS (Netherlands)

    Martens, Marieke Hendrikje; Jenssen, G.D.; Ingason, Haukur; Lönnermark, Anders

    2012-01-01

    Tunnel safety, especially in case of fires, has received a lot of attention due to heavy disasters. However, much attention is paid to controlling and extinguishing the fire, and not so much on the role of human behaviour. In this case, human behaviour includes the behaviour of road users, rail

  4. Wind tunnel tests of a free yawing downwind wind turbine

    NARCIS (Netherlands)

    Verelst, D.R.S.; Larsen, T.J.; Van Wingerden, J.W.

    2014-01-01

    This research paper presents preliminary results on a behavioural study of a free yawing downwind wind turbine. A series of wind tunnel tests was performed at the TU Delft Open Jet Facility with a three bladed downwind wind turbine and a rotor radius of 0.8 meters. The setup includes an off the

  5. Demonstration of the LHC Safety Training Tunnel Mock-Up

    CERN Multimedia

    Brice, Maximilien

    2014-01-01

    Members of CERN's management visit the LHC tunnel mock-up at the Safety Training Centre on the Prévessin site. The facility is used to train personnel in emergency responses including the use of masks and safe evacuation.

  6. Early diagnosis of Carpal Tunnel Syndrome (CTS) in Indian patients ...

    African Journals Online (AJOL)

    The present study was carried out for early confirmation of clinically diagnosed patients of Carpal Tunnel Syndrome (CTS) by electro-diagnostic tests which included motor conduction, sensory conduction studies and F-wave studies. The aim of the study was early confirmation of clinically suspected patients of CTS by motor ...

  7. Principle plug design for deposition tunnels

    International Nuclear Information System (INIS)

    Haaramo, M.; Lehtonen, A.

    2009-06-01

    protection of reinforcement. The tightness and the thickness of the concrete cover of the steel bars are tools that can be used to improve the situation. To avoid shrinkage and high generation of hydration heat the minimum volume of the aggregate should be 70% and in addition to cement, some other cementing agent should be used. The other cementing agent could be blast furnace cinder, fly ash or silica. The amount of cement needed is smallest with blast furnace cinder. It can be difficult to find cinder of a type with a suitable chemical consistency for repository use. The construction of the plug must start as soon as the backfilling of the deposition tunnel is completed. The estimated construction time of a plug is 40 days, including the hardening time of the concrete. The front wall of the backfill can be realized as a vertical plane. During the construction of the plug and the hardening of concrete the pressure of the backfill and the water is controlled by leakage tubes. In short term the plug can be subjected to a pressure smaller than the total pressure to be developed. The period between the completion of the backfill and the completion of the plug can be shortened through careful preliminary works. (orig.)

  8. Resonant tunnel magnetoresistance in a double magnetic tunnel junction

    KAUST Repository

    Useinov, Arthur

    2011-08-09

    We present quasi-classical approach to calculate a spin-dependent current and tunnel magnetoresistance (TMR) in double magnetic tunnel junctions (DMTJ) FML/I/FMW/I/FMR, where the magnetization of the middle ferromagnetic metal layer FMW can be aligned parallel or antiparallel with respect to the fixed magnetizations of the left FML and right FMR ferromagnetic electrodes. The transmission coefficients for components of the spin-dependent current, and TMR are calculated as a function of the applied voltage. As a result, we found a high resonant TMR. Thus, DMTJ can serve as highly effective magnetic nanosensor for biological applications, or as magnetic memory cells by switching the magnetization of the inner ferromagnetic layer FMW.© Springer Science+Business Media, LLC 2011.

  9. The Third Quantization: To Tunnel or Not to Tunnel?

    Directory of Open Access Journals (Sweden)

    Mariam Bouhmadi-López

    2018-02-01

    Full Text Available Within the framework of the third quantization, we consider the possibility that an initially recollapsing baby universe can enter a stage of near de Sitter inflation by tunnelling through a Euclidean wormhole that connects the recollapsing and inflationary geometries. We present the solutions for the evolution of the scale factor in the Lorentzian and Euclidean regions as well as the probability that the baby universe indeed crosses the wormhole when it reaches its maximum size.

  10. Wind-Tunnel Investigation of an NACA 23012 Airfoil with Various Arrangements of Slotted Flaps

    Science.gov (United States)

    Wenzinger, Carl J; Harris , Thomas A

    1939-01-01

    An investigation was made in the 7 by 10-foot wind tunnel and in the variable-density wind tunnel of the NACA 23012 airfoil with various slotted-flap arrangements. The purpose of the investigation in the 7 by 10-foot wind tunnel was to determine the airfoil section aerodynamic characteristics as affected by flap shape, slot shape, and flap location. The flap position for maximum lift; polars for arrangements favorable for take-off and climb; and complete lift, drag, and pitching-moment characteristics for selected optimum arrangements were determined. The best arrangements were tested in the variable-density tunnel at an effective Reynolds number of 8,000,000. In addition, data from both wind tunnels are included for plain, split, external-airfoil, and Fowler flaps for purposes of comparison.

  11. Does wrist immobilization following open carpal tunnel release improve functional outcome? A literature review.

    Science.gov (United States)

    Isaac, S M; Okoro, T; Danial, I; Wildin, C

    2010-07-11

    Carpal Tunnel Syndrome (CTS) is a compressive neuropathy of the median nerve in the carpal tunnel. It is the most common peripheral entrapment neuropathy. The surgical management includes dividing the flexor retinaculum to decompress the median nerve. Post-operative mobilization of the wrist is controversial. Some surgeons splint the wrist for 2-4 weeks whilst others encourage early mobilization. The literature has been inconclusive as to which method is most beneficial. The purpose of this study is to review the literature regarding the effectiveness of wrist immobilization following open carpal tunnel decompression. We reviewed all published clinical trials claiming to evaluate the mobility status following open carpal tunnel release. Studies not in the English language as well as those with small number of patients (n immobilization after open carpal tunnel decompression when compared to early mobilization.

  12. NbN/MgO/NbN SIS tunnel junctions for submm wave mixers

    Science.gov (United States)

    Stern, J. A.; Hunt, B. D.; Leduc, H. G.; Judas, A.; Mcgrath, W. R.; Cypher, S. R.; Khanna, S. K.

    1989-01-01

    The authors report on the fabrication and testing of all-refractory NbN/MgO/NbN SIS (superconductor-insulator-superconductor) tunnel junctions for use as high-frequency mixers. Progress in the development of techniques for the fabrication of submicron-area tunnel junctions is described. Junction structures which have been investigated include mesa, crossline, and edge geometries. Using reactive sputtering techniques, NbN tunnel junctions with critical currents in excess of 104 A/sq cm have been fabricated with Vm values as high as 65 mV and areas down to 0.1 sq micron. Specific capacitance measurements on NbN/MgO/NbN mesa-type tunnel junctions give values in the range 60-90 fF/sq micron. These SIS tunnel junctions have been integrated with antennas and coupling structures for mixer tests in a waveguide receiver at 207 GHz. Preliminary mixer results are reported.

  13. Computational Analysis of the Transonic Dynamics Tunnel Using FUN3D

    Energy Technology Data Exchange (ETDEWEB)

    Chwalowski, Pawel; Quon, Eliot; Brynildsen, Scott E.

    2016-01-04

    This paper presents results from an explanatory two-year effort of applying Computational Fluid Dynamics (CFD) to analyze the empty-tunnel flow in the NASA Langley Research Center Transonic Dynamics Tunnel (TDT). The TDT is a continuous-flow, closed circuit, 16- x 16-foot slotted-test-section wind tunnel, with capabilities to use air or heavy gas as a working fluid. In this study, experimental data acquired in the empty tunnel using the R-134a test medium was used to calibrate the computational data. The experimental calibration data includes wall pressures, boundary-layer profiles, and the tunnel centerline Mach number profiles. Subsonic and supersonic flow regimes were considered, focusing on Mach 0.5, 0.7 and Mach 1.1 in the TDT test section. This study discusses the computational domain, boundary conditions, and initial conditions selected in the resulting steady-state analyses using NASA's FUN3D CFD software.

  14. Carpal tunnel syndrome is associated with high fibrinogen and fibrinogen deposits.

    Science.gov (United States)

    Utrobičić, Ivan; Novak, Ivana; Marinović-Terzić, Ivana; Matić, Katarina; Lessel, Davor; Salamunić, Ilza; Babić, Mirna Saraga; Kunac, Nenad; Mešin, Anka Koštić; Kubisch, Christian; Maček, Boris; Terzić, Janoš

    2014-09-01

    Idiopathic carpal tunnel syndrome (ICTS) is a common entrapment neuropathy. Some cases of ICTS are linked to mutations of the transthyretin gene, whereas others are associated with systemic amyloidosis. The majority of ICTS cases are of unknown etiology. To study molecular mechanisms of ICTS development. A total of 71 ICTS patients and 68 control subjects were included in the study. The fibrinogen level was determined before surgery and its deposition in the transversal carpal ligament (TCL) was detected by immunohistochemistry, Western blot, and mass spectrometry. Fibrinogen interaction with other proteins was studied by immunoprecipitation assay. Plasma levels of the proinflammatory and hemostatic protein fibrinogen are elevated in ICTS patients. Other measured systemic inflammatory markers were not affected, and local inflammatory responses in TCL were absent. ICTS patients have shorter bleeding times, probably because of the elevated plasma levels of fibrinogen. Polymorphisms of the fibrinogen B promoter region were previously associated with increased plasma fibrinogen, but this association was not observed among patients with ICTS. Interestingly, we detected fibrinogen deposits in the TCL, whereas transcriptional activity of the fibrinogen genes was low. Amyloidogenic proteins, including transthyretin and α-synuclein, were also found in the TCL, whereas their local transcriptional activity was rather high. Finally, we demonstrated that fibrinogen interacts with transthyretin and α-synuclein in TCL lysates. Our data indicate that fibrinogen and other aggregation-prone proteins have potentially important roles in the pathogenesis of ICTS.

  15. Preferences in Sleep Position Correlate With Nighttime Paresthesias in Healthy People Without Carpal Tunnel Syndrome.

    Science.gov (United States)

    Roth Bettlach, Carrie L; Hasak, Jessica M; Krauss, Emily M; Yu, Jenny L; Skolnick, Gary B; Bodway, Greta N; Kahn, Lorna C; Mackinnon, Susan E

    2017-10-01

    Carpal tunnel syndrome has been associated with sleep position preferences. The aim of this study is to assess self-reported nocturnal paresthesias and sleeping position in participants with and without carpal tunnel syndrome diagnosis to further clinical knowledge for preventive and therapeutic interventions. A cross-sectional survey study of 396 participants was performed in young adults, healthy volunteers, and a patient population. Participants were surveyed on risk factors for carpal tunnel syndrome, nocturnal paresthesias, and sleep preferences. Binary logistic regression analysis was performed comparing participants with rare and frequent nocturnal paresthesias. Subanalyses for participants without carpal tunnel syndrome under and over 21 years of age were performed on all factors significantly associated with subclinical compression neuropathy in the overall population. Thirty-three percent of the study population experienced nocturnal paresthesias at least weekly. Increased body mass index ( P < .001) and sleeping with the wrist flexed ( P = .030) were associated with a higher frequency of nocturnal paresthesias. Side sleeping was associated with less frequent nocturnal symptoms ( P = .003). In participants without carpal tunnel syndrome, subgroup analysis illustrated a relationship between nocturnal paresthesias and wrist position. In participants with carpal tunnel syndrome, sleeping on the side had a significantly reduced frequency of nocturnal paresthesias. This study illustrates nocturnal paresthesias in people without history of carpal tunnel syndrome including people younger than previously reported. In healthy patients with upper extremity subclinical compression neuropathy, sleep position modification may be a useful intervention to reduce the frequency of nocturnal symptoms prior to developing carpal tunnel syndrome.

  16. Molecular modeling study on tunnel behavior in different histone deacetylase isoforms.

    Directory of Open Access Journals (Sweden)

    Sundarapandian Thangapandian

    Full Text Available Histone deacetylases (HDACs have emerged as effective therapeutic targets in the treatment of various diseases including cancers as these enzymes directly involved in the epigenetic regulation of genes. However the development of isoform-selective HDAC inhibitors has been a challenge till date since all HDAC enzymes possess conserved tunnel-like active site. In this study, using molecular dynamics simulation we have analyzed the behavior of tunnels present in HDAC8, 10, and 11 enzymes of class I, II, and IV, respectively. We have identified the equivalent tunnel forming amino acids in these three isoforms and found that they are very much conserved with subtle differences to be utilized in selective inhibitor development. One amino acid, methionine of HDAC8, among six tunnel forming residues is different in isoforms of other classes (glutamic acid (E in HDAC10 and leucine (L in HDAC 11 based on which mutations were introduced in HDAC11, the less studied HDAC isoform, to observe the effects of this change. The HDAC8-like (L268M mutation in the tunnel forming residues has almost maintained the deep and narrow tunnel as present in HDAC8 whereas HDAC10-like (L268E mutation has changed the tunnel wider and shallow as observed in HDAC10. These results explained the importance of the single change in the tunnel formation in different isoforms. The observations from this study can be utilized in the development of isoform-selective HDAC inhibitors.

  17. Dynamic Response of Underground Circular Lining Tunnels Subjected to Incident P Waves

    Directory of Open Access Journals (Sweden)

    Hua Xu

    2014-01-01

    Full Text Available Dynamic stress concentration in tunnels and underground structures during earthquakes often leads to serious structural damage. A series solution of wave equation for dynamic response of underground circular lining tunnels subjected to incident plane P waves is presented by Fourier-Bessel series expansion method in this paper. The deformation and stress fields of the whole medium of surrounding rock and tunnel were obtained by solving the equations of seismic wave propagation in an elastic half space. Based on the assumption of a large circular arc, a series of solutions for dynamic stress were deduced by using a wave function expansion approach for a circular lining tunnel in an elastic half space rock medium subjected to incident plane P waves. Then, the dynamic response of the circular lining tunnel was obtained by solving a series of algebraic equations after imposing its boundary conditions for displacement and stress of the circular lining tunnel. The effects of different factors on circular lining rock tunnels, including incident frequency, incident angle, buried depth, rock conditions, and lining stiffness, were derived and several application examples are presented. The results may provide a good reference for studies on the dynamic response and aseismic design of tunnels and underground structures.

  18. Development of a 3D modeling algorithm for tunnel deformation monitoring based on terrestrial laser scanning

    Directory of Open Access Journals (Sweden)

    Xiongyao Xie

    2017-03-01

    Full Text Available Deformation monitoring is vital for tunnel engineering. Traditional monitoring techniques measure only a few data points, which is insufficient to understand the deformation of the entire tunnel. Terrestrial Laser Scanning (TLS is a newly developed technique that can collect thousands of data points in a few minutes, with promising applications to tunnel deformation monitoring. The raw point cloud collected from TLS cannot display tunnel deformation; therefore, a new 3D modeling algorithm was developed for this purpose. The 3D modeling algorithm includes modules for preprocessing the point cloud, extracting the tunnel axis, performing coordinate transformations, performing noise reduction and generating the 3D model. Measurement results from TLS were compared to the results of total station and numerical simulation, confirming the reliability of TLS for tunnel deformation monitoring. Finally, a case study of the Shanghai West Changjiang Road tunnel is introduced, where TLS was applied to measure shield tunnel deformation over multiple sections. Settlement, segment dislocation and cross section convergence were measured and visualized using the proposed 3D modeling algorithm.

  19. Double-Barrier Resonant Tunneling in Three and Two Dimensions

    Science.gov (United States)

    Zaslavsky, Alexander

    Double-barrier resonant tunneling devices have attracted great scientific interest, both as novel physical systems based on strong size quantization that exhibit unusual transport behavior and also as a promising class of semiconductor structures for high-speed electronic devices. This thesis describes the physics of transport in double-barrier structures fabricated by conventional planar growth, where the fundamental process involves tunneling from three-dimensional (3D) into two-dimensional (2D) densities of electronic states, as well as in novel 2D double-barrier structures fabricated by regrowth, where 2D electrons tunnel into well-separated ID quantum wire subbands. A brief introduction to the basic theory of resonant tunneling and the results of low-temperature I(V) transport measurements on high -quality planar double-barrier devices is presented in Chapter 1. Chapter 2 examines the bistable I(V) characteristic observed in specially designed asymmetric devices, with the intrinsic nature of this effect confirmed by parallel field magnetotunneling measurements. In Chapter 3 transverse field magnetotunneling is employed to experimentally verify the energy and transverse momentum selection rules that govern transport in resonant tunneling devices. Chapter 4 focuses on the fabrication of 2D resonant tunneling devices by liquid phase epitaxial regrowth on patterned substrates. A brief overview of liquid phase epitaxy and two different in-situ patterning techniques--selective meltback and cleaving inside the chamber--are presented. The measurements of the 2D device fabricated by regrowth on cleaved substrates are presented and analyzed in Chapter 5. The new possibilities opened up by the cleaved substrate regrowth techniques are also discussed, including the realization of an edge -regrown superlattice with novel high-field transport characteristics.

  20. SMART Rotor Development and Wind-Tunnel Test

    Science.gov (United States)

    Lau, Benton H.; Straub, Friedrich; Anand, V. R.; Birchette, Terry

    2009-01-01

    Boeing and a team from Air Force, NASA, Army, Massachusetts Institute of Technology, University of California at Los Angeles, and University of Maryland have successfully completed a wind-tunnel test of the smart material actuated rotor technology (SMART) rotor in the 40- by 80-foot wind-tunnel of the National Full-Scale Aerodynamic Complex at NASA Ames Research Center, figure 1. The SMART rotor is a full-scale, five-bladed bearingless MD 900 helicopter rotor modified with a piezoelectric-actuated trailing-edge flap on each blade. The development effort included design, fabrication, and component testing of the rotor blades, the trailing-edge flaps, the piezoelectric actuators, the switching power amplifiers, the actuator control system, and the data/power system. Development of the smart rotor culminated in a whirl-tower hover test which demonstrated the functionality, robustness, and required authority of the active flap system. The eleven-week wind tunnel test program evaluated the forward flight characteristics of the active-flap rotor, gathered data to validate state-of-the-art codes for rotor noise analysis, and quantified the effects of open- and closed-loop active-flap control on rotor loads, noise, and performance. The test demonstrated on-blade smart material control of flaps on a full-scale rotor for the first time in a wind tunnel. The effectiveness and the reliability of the flap actuation system were successfully demonstrated in more than 60 hours of wind-tunnel testing. The data acquired and lessons learned will be instrumental in maturing this technology and transitioning it into production. The development effort, test hardware, wind-tunnel test program, and test results will be presented in the full paper.

  1. In-vehicle nitrogen dioxide concentrations in road tunnels

    Science.gov (United States)

    Martin, Ashley N.; Boulter, Paul G.; Roddis, Damon; McDonough, Liza; Patterson, Michael; Rodriguez del Barco, Marina; Mattes, Andrew; Knibbs, Luke D.

    2016-11-01

    There is a lack of knowledge regarding in-vehicle concentrations of nitrogen dioxide (NO2) during transit through road tunnels in urban environments. Furthermore, previous studies have tended to involve a single vehicle and the range of in-vehicle NO2 concentrations that vehicle occupants may be exposed to is not well defined. This study describes simultaneous measurements of in-vehicle and outside-vehicle NO2 concentrations on a route through Sydney, Australia that included several major tunnels, minor tunnels and busy surface roads. Tests were conducted on nine passenger vehicles to assess how vehicle characteristics and ventilation settings affected in-vehicle NO2 concentrations and the in-vehicle-to-outside vehicle (I/O) concentration ratio. NO2 was measured directly using a cavity attenuated phase shift (CAPS) technique that gave a high temporal and spatial resolution. In the major tunnels, transit-average in-vehicle NO2 concentrations were lower than outside-vehicle concentrations for all vehicles with cabin air recirculation either on or off. However, markedly lower I/O ratios were obtained with recirculation on (0.08-0.36), suggesting that vehicle occupants can significantly lower their exposure to NO2 in tunnels by switching recirculation on. The highest mean I/O ratios for NO2 were measured in older vehicles (0.35-0.36), which is attributed to older vehicles having higher air exchange rates. The results from this study can be used to inform the design and operation of future road tunnels and modelling of personal exposure to NO2.

  2. Tunneling magnetoresistance in Si nanowires

    KAUST Repository

    Montes Muñoz, Enrique

    2016-11-09

    We investigate the tunneling magnetoresistance of small diameter semiconducting Si nanowires attached to ferromagnetic Fe electrodes, using first principles density functional theory combined with the non-equilibrium Green\\'s functions method for quantum transport. Silicon nanowires represent an interesting platform for spin devices. They are compatible with mature silicon technology and their intrinsic electronic properties can be controlled by modifying the diameter and length. Here we systematically study the spin transport properties for neutral nanowires and both n and p doping conditions. We find a substantial low bias magnetoresistance for the neutral case, which halves for an applied voltage of about 0.35 V and persists up to 1 V. Doping in general decreases the magnetoresistance, as soon as the conductance is no longer dominated by tunneling.

  3. Tunneling of a coupled system

    International Nuclear Information System (INIS)

    Avishai, Y.

    1985-01-01

    We consider tunneling through a potential barrier V(x) in the presence of a coupling term W(x,y). Let H(y) be the internal Hamiltonian associated with the coordinate y and let E 0 (x) be the ground state energy of the operator H(x;y) = H(y) + W(x,y) in which x is a parameter. Our result for the tunneling probability (in the WKB approximation) is P = exp(2i ∫ k 0 (x)dx) where, at energy E, k 0 (x) = [E-E 0 (x)-V(x)]sup(1/2)/(h/2π) is the local wave number in the presence of coupling. (orig.)

  4. Seismic scanning tunneling macroscope - Theory

    KAUST Repository

    Schuster, Gerard T.

    2012-09-01

    We propose a seismic scanning tunneling macroscope (SSTM) that can detect the presence of sub-wavelength scatterers in the near-field of either the source or the receivers. Analytic formulas for the time reverse mirror (TRM) profile associated with a single scatterer model show that the spatial resolution limit to be, unlike the Abbe limit of λ/2, independent of wavelength and linearly proportional to the source-scatterer separation as long as the point scatterer is in the near-field region; if the sub-wavelength scatterer is a spherical impedance discontinuity then the resolution will also be limited by the radius of the sphere. Therefore, superresolution imaging can be achieved as the scatterer approaches the source. This is analogous to an optical scanning tunneling microscope that has sub-wavelength resolution. Scaled to seismic frequencies, it is theoretically possible to extract 100 Hz information from 20 Hz data by imaging of near-field seismic energy.

  5. Digging the CNGS decay tunnel

    CERN Multimedia

    Patrice Loiez

    2002-01-01

    Products of the collision between a proton beam and a graphite target will pass through a horn containing an electric field that will produce a focused beam. These particles will decay into muon neutrinos within the tunnel that is being constructed in these images. The neutrinos will then travel 730 km to Gran Sasso in Italy where huge detectors will observe the beam to study a process called neutrino oscillation.

  6. Dissipative Effect and Tunneling Time

    Directory of Open Access Journals (Sweden)

    Samyadeb Bhattacharya

    2011-01-01

    Full Text Available The quantum Langevin equation has been studied for dissipative system using the approach of Ford et al. Here, we have considered the inverted harmonic oscillator potential and calculated the effect of dissipation on tunneling time, group delay, and the self-interference term. A critical value of the friction coefficient has been determined for which the self-interference term vanishes. This approach sheds new light on understanding the ion transport at nanoscale.

  7. Tunnel Cost-Estimating Methods.

    Science.gov (United States)

    1981-10-01

    Mayo, R. S., Barrett, J. E., and Jenny, R. J. 1976. "Tunneling: The State of the Industry ," Report No. DOT-TSC-OST-76-29, Department of Transporta...as a... C *YPAUS CHECK FOR HOTAL INPUT 1F(ELNJL.GT.-1s.Eag.AND.ELNPR.GT.-Ig.E29) GO TO St *OSS3@ *I00 WRITEILO,1031) NTSEG.NREACH 04540 MI ISTOP-i

  8. Diagnosis of Carpal Tunnel Syndrome

    OpenAIRE

    Keith, Michael Warren; Masear, Victoria; Chung, Kevin; Maupin, Kent; Andary, Michael; Amadio, Peter C.; Barth, Richard W.; Watters, William C.; Goldberg, Michael J.; Haralson, Robert H.; Turkelson, Charles M.; Wies, Janet L.

    2009-01-01

    This clinical practice guideline was created to improve patient care by outlining the appropriate information-gathering and decision-making processes involved in managing the diagnosis of carpal tunnel syndrome. The methods used to develop this clinical practice guideline were designed to combat bias, enhance transparency, and promote reproducibility. The guideline’s recommendations are as follows: The physician should obtain an accurate patient history. The physician should perform a physica...

  9. Autonomous Robotic Inspection in Tunnels

    Science.gov (United States)

    Protopapadakis, E.; Stentoumis, C.; Doulamis, N.; Doulamis, A.; Loupos, K.; Makantasis, K.; Kopsiaftis, G.; Amditis, A.

    2016-06-01

    In this paper, an automatic robotic inspector for tunnel assessment is presented. The proposed platform is able to autonomously navigate within the civil infrastructures, grab stereo images and process/analyse them, in order to identify defect types. At first, there is the crack detection via deep learning approaches. Then, a detailed 3D model of the cracked area is created, utilizing photogrammetric methods. Finally, a laser profiling of the tunnel's lining, for a narrow region close to detected crack is performed; allowing for the deduction of potential deformations. The robotic platform consists of an autonomous mobile vehicle; a crane arm, guided by the computer vision-based crack detector, carrying ultrasound sensors, the stereo cameras and the laser scanner. Visual inspection is based on convolutional neural networks, which support the creation of high-level discriminative features for complex non-linear pattern classification. Then, real-time 3D information is accurately calculated and the crack position and orientation is passed to the robotic platform. The entire system has been evaluated in railway and road tunnels, i.e. in Egnatia Highway and London underground infrastructure.

  10. Tunneling beyond the Fermilab site

    International Nuclear Information System (INIS)

    Baker, S.; Elwyn, A.; Lach, J.; Read, A.

    1983-01-01

    An accelerator that crosses the Fermilab site boundary must have a minimum effect on the surrounding environment and the people residing in the area. Unobstructed public access should be allowed above the ring except in relatively few areas such as the injection, dump, and experimental regions. The accelerator should be a benign and unobtrusive neighbor not only when it is completed but also in the construction period. For these reasons underground tunneling for all or most of the ring seems attractive. In this note we look into some questions raised by tunneling beyond the Fermilab site. Most of our discussion is of general applicability. However, we will use as examples two specific ring configurations. The examples have not been optimized from the point of view of physics output or accelerator technology but are just specific examples which allow us to study questions of tunneling. One is a ring of 5 km radius (5 TeV) tangent to the Tevatron and entirely east of the Fox River and fed by a beam from the Tevatron which crosses under the river. We assume that each of these machines will have 100 beam fills per year and we scale the maximum intensities with the accelerator radii. Thus we assume that there will be 1.0 E14 protons in each beam of the 20 TeV machine and 2.5 E13 for the 5 TeV machine

  11. Variability in ACL tunnel placement: observational clinical study of surgeon ACL tunnel variability.

    Science.gov (United States)

    Wolf, Brian R; Ramme, Austin J; Wright, Rick W; Brophy, Robert H; McCarty, Eric C; Vidal, Armando R; Parker, Richard D; Andrish, Jack T; Amendola, Annunziato

    2013-06-01

    Multicenter and multisurgeon cohort studies on anterior cruciate ligament (ACL) reconstruction are becoming more common. Minimal information exists on intersurgeon and intrasurgeon variability in ACL tunnel placement. Purpose/ The purpose of this study was to analyze intersurgeon and intrasurgeon variability in ACL tunnel placement in a series of The Multicenter Orthopaedic Outcomes Network (MOON) ACL reconstruction patients and in a clinical cohort of ACL reconstruction patients. The hypothesis was that there would be minimal variability between surgeons in ACL tunnel placement. Cross-sectional study; Level of evidence, 3. Seventy-eight patients who underwent ACL reconstruction by 8 surgeons had postoperative imaging with computed tomography, and ACL tunnel location and angulation were analyzed using 3-dimensional surface processing and measurement. Intersurgeon and intrasurgeon variability in ACL tunnel placement was analyzed. For intersurgeon variability, the range in mean ACL femoral tunnel depth between surgeons was 22%. For femoral tunnel height, there was a 19% range. Tibial tunnel location from anterior to posterior on the plateau had a 16% range in mean results. There was only a small range of 4% for mean tibial tunnel location from the medial to lateral dimension. For intrasurgeon variability, femoral tunnel depth demonstrated the largest ranges, and tibial tunnel location from medial to lateral on the plateau demonstrated the least variability. Overall, surgeons were relatively consistent within their own cases. Using applied measurement criteria, 85% of femoral tunnels and 90% of tibial tunnels fell within applied literature-based guidelines. Ninety-one percent of the axes of the femoral tunnels fell within the boundaries of the femoral footprint. The data demonstrate that surgeons performing ACL reconstructions are relatively consistent between each other. There is, however, variability of average tunnel placement up to 22% of mean condylar depth

  12. The Significance of Immunohistochemical Staining, Including that for Glucose Transporter Protein Isoform 1, as Related to the Clinical and Angiographic Features of Adult Soft-Tissue Hemangioma and Arteriovenous Malformation in the Head and Neck

    International Nuclear Information System (INIS)

    Lee, Ha Young; Kim, Seon Mi; Choi, Jin Woo

    2009-01-01

    Glucose transporter protein isoform 1 (GLUT1) has been introduced to diagnose the hemangiomas of infancy. We investigated the usefulness of several immunohistochemical markers, including GLUT1, as related with the clinical and radiologic findings for making the diagnosis of adult subcutaneous vascular lesions in the head and neck. Materials and Methods: The 24 patients who underwent operations for soft tissue vascular lesion during the previous 7 years were included in this study. We analyzed the angiographic data, the clinical data and the immunohistochemical study results, including the GLUT1, S-100 protein and Movat pentichrome staining. Results: Twenty-two patients were confirmed to have arteriovenous malformation (AVM) and two hemangiomas, respectively. The number of lesions with positive Movat pentichrome, S-100 and GLUT1 staining in the patients with AVM and those patients with hemangioma were 22/22, 20/22 and 0/22, and 0/2, 0/2 and 0/2, respectively. For the 22 patients with AVMs, eight had a soft tissue vascular lesion at birth, 13 had cutaneous change and 15 had a change of the size of the lesion. For the 2 patients with one hemangioma each, neither patient had a soft tissue vascular lesion at birth, and both patients had cutaneous change and a change of the size of the lesion. The angiograms revealed a focal hypervascular mass (19/24) or diffuse staining (5/24) without showing significant features for making the definitive differential diagnosis. Our study revealed that none of the patients with AVM or hemangioma had GLUT1 positivity, and an arteriovenous malformation was more common than the adult-type hemangioma

  13. New vision of magnetic tunnelling

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, Jonathan R. [Amherst College, Amhurst, MA (United States)

    2002-01-01

    Recent experiments support the idea that crystal defects may be responsible for the quantum tunnelling of magnetic moments in molecular magnets at low temperatures. The magnetic moment of a typical bar magnet will never spontaneously reverse direction. However, thermal fluctuations can flip the moment of a magnetic particle just a few nanometres across. The particle can be cooled to nearly absolute zero to suppress this process, but the moment may still find a way to reverse via quantum tunnelling. Quantum tunnelling of magnetization has been the subject of decades of research. Until a few years ago, however, there had only been circumstantial evidence for the phenomenon. This is because most systems of small magnetic particles are hard to characterize - the particles have a variety of shapes, sizes and other properties, making it difficult to compare data with theory. Some real progress was made a few years ago through research into high-spin single-molecule magnets. With dimensions of about a nanometre, these magnets are usually composed of a magnetic core that is surrounded by organic complexes. When they crystallize into a regular lattice, the organic ions keep neighbouring magnets well separated so that they interact only weakly. Ideally all the molecules are identical because they have been built chemically, which means that they can be characterized precisely and that any data can be analysed quantitatively. The most studied of these molecules is manganese-12 acetate (Mn{sub 12}). Within each molecule, the spins of the eight Mn{sup 3+} ions (each with S=2) are antiparallel to the spins of the four Mn{sup 4+} ions (each with S=3/2), giving Mn{sub 12} a total spin of S=10. Or, to put it another way, the magnetic moment of Mn{sub 12} is 20 times larger than that of the electron. Now Eugene Chudnovsky of Lehman College in New York and Dmitry Garanin of the University of Mainz in Germany have suggested a new mechanism for producing tunnelling in Mn{sub 12

  14. Evaluation of the scratch collapse test for the diagnosis of carpal tunnel syndrome

    NARCIS (Netherlands)

    Makanji, H. S.; Becker, S. J. E.; Mudgal, C. S.; Jupiter, J. B.; Ring, D.

    2014-01-01

    This prospective study measured and compared the diagnostic performance characteristics of various clinical signs and physical examination manoeuvres for carpal tunnel syndrome (CTS), including the scratch collapse test. Eighty-eight adult patients that were prescribed electrophysiological testing

  15. Neuroreceptor activation by vibration-assisted tunneling.

    Science.gov (United States)

    Hoehn, Ross D; Nichols, David; Neven, Hartmut; Kais, Sabre

    2015-04-24

    G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous value for pharmacology and drug design. Inelastic electron tunneling spectroscopy (IETS) has been proposed as a model for the mechanism by which olfactory GPCRs are activated by a bound agonist. We apply this hyothesis to GPCRs within the mammalian nervous system using quantum chemical modeling. We found that non-endogenous agonists of the serotonin receptor share a particular IET spectral aspect both amongst each other and with the serotonin molecule: a peak whose intensity scales with the known agonist potencies. We propose an experiential validation of this model by utilizing lysergic acid dimethylamide (DAM-57), an ergot derivative, and its deuterated isotopologues; we also provide theoretical predictions for comparison to experiment. If validated our theory may provide new avenues for guided drug design and elevate methods of in silico potency/activity prediction.

  16. Tunnel barrier schottky

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Rongming; Cao, Yu; Li, Zijian; Williams, Adam J.

    2018-02-20

    A diode includes: a semiconductor substrate; a cathode metal layer contacting a bottom of the substrate; a semiconductor drift layer on the substrate; a graded aluminum gallium nitride (AlGaN) semiconductor barrier layer on the drift layer and having a larger bandgap than the drift layer, the barrier layer having a top surface and a bottom surface between the drift layer and the top surface, the barrier layer having an increasing aluminum composition from the bottom surface to the top surface; and an anode metal layer directly contacting the top surface of the barrier layer.

  17. Chaos regularization of quantum tunneling rates

    International Nuclear Information System (INIS)

    Pecora, Louis M.; Wu Dongho; Lee, Hoshik; Antonsen, Thomas; Lee, Ming-Jer; Ott, Edward

    2011-01-01

    Quantum tunneling rates through a barrier separating two-dimensional, symmetric, double-well potentials are shown to depend on the classical dynamics of the billiard trajectories in each well and, hence, on the shape of the wells. For shapes that lead to regular (integrable) classical dynamics the tunneling rates fluctuate greatly with eigenenergies of the states sometimes by over two orders of magnitude. Contrarily, shapes that lead to completely chaotic trajectories lead to tunneling rates whose fluctuations are greatly reduced, a phenomenon we call regularization of tunneling rates. We show that a random-plane-wave theory of tunneling accounts for the mean tunneling rates and the small fluctuation variances for the chaotic systems.

  18. Tunneling anisotropic magnetoresistance in Co/AIOx/Al tunnel junctions with fcc Co (111) electrodes

    NARCIS (Netherlands)

    Wang, Kai; Tran, T. Lan Ahn; Brinks, Peter; Brinks, P.; Sanderink, Johannes G.M.; Bolhuis, Thijs; van der Wiel, Wilfred Gerard; de Jong, Machiel Pieter

    2013-01-01

    Tunneling anisotropic magnetoresistance (TAMR) has been characterized in junctions comprised of face-centered cubic (fcc) Co (111) ferromagnetic electrodes grown epitaxially on sapphire substrates, amorphous AlOx tunnel barriers, and nonmagnetic Al counterelectrodes. Large TAMR ratios have been

  19. The Usefulness of the Preoperative Magnetic Resonance Imaging Findings in the Evaluation of Tarsal Tunnel Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Hyun Jin; Lee, Sheen Woo; Jeong, Yu Mi; Choi, Hye Young; Kim, Hyung Sik [Dept. of Radiology, Gil Hospital, Gacheon University College of Medicine, Incheon (Korea, Republic of); Park, Hong Gi; Kwak, Ji Hoon [Dept. of Orthopedic Surgery, Gil Hospital, Gacheon University College of Medicine, Incheon (Korea, Republic of)

    2012-02-15

    The purpose of this study was to access the diverse conditions that lead to the clinical manifestations of tarsal tunnel syndrome and evaluate the usefulness of magnetic resonance imaging (MRI) in preoperative evaluation. Thirty-three patients who underwent ankle MRI and surgery under the impression of tarsal tunnel syndrome were retrospectively analyzed. The findings on ankle MRI were categorized into space occupying lesions within the tarsal tunnel, space occupying lesions of the tunnel wall, and non-space occupying lesions. Associated plantar muscle atrophy was also evaluated. Medical records were reviewed for correlation of nerve conduction velocity (NCV) and surgical findings. There were 21 space occupying lesions of the tarsal tunnel, and eight lesions of tarsal tunnel wall. There were three cases with accessory muscle, three with tarsal coalition, five with ganglion cysts, one neurogenic tumor, five flexor retinaculum hypertrophy, three varicose veins, and nine with tenosynovitis of the posterior tibialis, flexor digitorum longus, or flexor hallucis longus tendon. One patient was found to have a deltoid ligament sprain. Of the 32, eight patients experienced fatty atrophic change within any one of the foot muscles. NCV was positive in 79% of the MRI-positive lesions. MRI provides detailed information on ankle anatomy, which includes that of tarsal tunnel and beyond. Pathologic conditions that cause or mimic tarsal tunnel syndrome are well demonstrated. MRI can enhance surgical planning by indicating the extent of decompression required, and help with further patient management. Patients with tarsal tunnel syndrome can greatly benefit from preoperative MRI. However, it should be noted that not all cases with tarsal tunnel syndrome have MRI-demonstrable causes.

  20. The Usefulness of the Preoperative Magnetic Resonance Imaging Findings in the Evaluation of Tarsal Tunnel Syndrome

    International Nuclear Information System (INIS)

    Jung, Hyun Jin; Lee, Sheen Woo; Jeong, Yu Mi; Choi, Hye Young; Kim, Hyung Sik; Park, Hong Gi; Kwak, Ji Hoon

    2012-01-01

    The purpose of this study was to access the diverse conditions that lead to the clinical manifestations of tarsal tunnel syndrome and evaluate the usefulness of magnetic resonance imaging (MRI) in preoperative evaluation. Thirty-three patients who underwent ankle MRI and surgery under the impression of tarsal tunnel syndrome were retrospectively analyzed. The findings on ankle MRI were categorized into space occupying lesions within the tarsal tunnel, space occupying lesions of the tunnel wall, and non-space occupying lesions. Associated plantar muscle atrophy was also evaluated. Medical records were reviewed for correlation of nerve conduction velocity (NCV) and surgical findings. There were 21 space occupying lesions of the tarsal tunnel, and eight lesions of tarsal tunnel wall. There were three cases with accessory muscle, three with tarsal coalition, five with ganglion cysts, one neurogenic tumor, five flexor retinaculum hypertrophy, three varicose veins, and nine with tenosynovitis of the posterior tibialis, flexor digitorum longus, or flexor hallucis longus tendon. One patient was found to have a deltoid ligament sprain. Of the 32, eight patients experienced fatty atrophic change within any one of the foot muscles. NCV was positive in 79% of the MRI-positive lesions. MRI provides detailed information on ankle anatomy, which includes that of tarsal tunnel and beyond. Pathologic conditions that cause or mimic tarsal tunnel syndrome are well demonstrated. MRI can enhance surgical planning by indicating the extent of decompression required, and help with further patient management. Patients with tarsal tunnel syndrome can greatly benefit from preoperative MRI. However, it should be noted that not all cases with tarsal tunnel syndrome have MRI-demonstrable causes.

  1. The anatomy and histology of the bicipital tunnel of the shoulder.

    Science.gov (United States)

    Taylor, Samuel A; Fabricant, Peter D; Bansal, Manjula; Khair, M Michael; McLawhorn, Alexander; DiCarlo, Edward F; Shorey, Mary; O'Brien, Stephen J

    2015-04-01

    The bicipital tunnel is the extra-articular, fibro-osseous structure that encloses the long head of the biceps tendon. Twelve cadaveric shoulder specimens underwent in situ casting of the bicipital tunnel with methyl methacrylate cement to demonstrate structural competence (n = 6) and en bloc harvest with gross and histologic evaluation (n = 6). The percentage of empty tunnel was calculated histologically by subtracting the proportion of cross-sectional area of the long head of the biceps tendon from that of the bicipital tunnel for each zone. Cement casting demonstrated that the bicipital tunnel was a closed space. Zone 1 extended from the articular margin to the distal margin of the subscapularis tendon. Zone 2 extended from the distal margin of the subscapularis tendon to the proximal margin of the pectoralis major tendon. Zone 3 was the subpectoral region. Zones 1 and 2 were both enclosed by a dense connective tissue sheath and demonstrated the presence of synovium. Zone 3 had significantly greater percentage of empty tunnel than zones 1 and 2 did (P bicipital tunnel is a closed space with 3 distinct zones. Zones 1 and 2 have similar features, including the presence of synovium, but differ from zone 3. A significant bottleneck occurs between zone 2 and zone 3, most likely at the proximal margin of the pectoralis major tendon. The bicipital tunnel is a closed space where space-occupying lesions may produce a bicipital tunnel syndrome. Careful consideration should be given to surgical techniques that decompress both zones 1 and 2 of the bicipital tunnel. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  2. Prospective, randomized evaluation of endoscopic versus open carpal tunnel release in bilateral carpal tunnel syndrome: an interim analysis.

    Science.gov (United States)

    Michelotti, Brett; Romanowsky, Diane; Hauck, Randy M

    2014-12-01

    Most randomized trials have shown similar results with endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR); however, there are studies suggesting less postoperative pain, faster improvement in grip and pinch strength, and earlier return to work with the endoscopic technique. The goal of this study was to prospectively examine subjective and functional outcomes, satisfaction, and complications after both ECTR and OCTR in the opposite hands of the same patient, serving as their own control. This was a prospective, randomized study in which patients underwent surgery for bilateral carpal tunnel syndrome. The first carpal tunnel release was performed on the most symptomatic hand-determined by the patient. Operative approach was randomly assigned and, approximately 1 month later, the alternative technique was performed on the contralateral side. Demographic data were obtained, and functional outcomes were recorded preoperatively and postoperatively, including pain score, 2-point discrimination, Semmes-Weinstein monofilament testing, thenar strength, and overall grip strength. The carpal tunnel syndrome-functional status score and carpal tunnel syndrome-symptom severity score were recorded before surgery and at 2, 4, 8, 12, and 24 weeks postoperatively. Overall satisfaction with each technique was recorded at the conclusion of the study. Currently, 25 subjects have completed final visit testing. There were no differences in pain score, 2-point discrimination, Semmes-Weinstein monofilament testing, thenar strength, or overall grip strength at any of the postoperative time points. Carpal tunnel syndrome-symptom severity score and carpal tunnel syndrome-functional status score were not significantly different between groups at any of the evaluations. Overall satisfaction, where patients recorded a number from 0 to 100, was significantly greater in the ECTR group (95.95 vs 91.60, P = 0.04). There were no complications with either technique. This

  3. PUREX Storage Tunnels dangerous waste permit application

    International Nuclear Information System (INIS)

    1991-12-01

    This report is part of a dangerous waste permit application for the storage of wastes from the Purex process at Hanford. Appendices are presented on the following: construction drawings; HSW-5638, specifications for disposal facility for failed equipment, Project CA-1513-A; HWS-8262, specification for Purex equipment disposal, Project CGC 964; storage tunnel checklist; classification of residual tank heels in Purex storage tunnels; emergency plan for Purex facility; training course descriptions; and the Purex storage tunnels engineering study

  4. Climatic wind tunnel for wind engineering tasks

    Czech Academy of Sciences Publication Activity Database

    Kuznetsov, Sergeii; Pospíšil, Stanislav; Král, Radomil

    2015-01-01

    Roč. 112, 2-B (2015), s. 303-316 ISSN 1897-628X R&D Projects: GA ČR(CZ) GA14-12892S Keywords : climatic tunnel * wind tunnel * atmospheric boundary layer * flow resistance * wind tunnel contraction Subject RIV: JM - Building Engineering https://suw.biblos.pk.edu.pl/resources/i5/i6/i6/i7/i6/r56676/KuznetsovS_ClimaticWind.pdf

  5. Intralesional immunotherapy with tuberculin purified protein derivative (PPD) in recalcitrant wart: A randomized, placebo-controlled, double-blind clinical trial including an extra group of candidates for cryotherapy.

    Science.gov (United States)

    Amirnia, Mehdi; Khodaeiani, Effat; Fouladi, Daniel F; Masoudnia, Sima

    2016-01-01

    Due to paucity of randomized clinical trials, intralesional immunotherapy has not been yet accepted as a standard therapeutic method. To examine the efficacy and safety of intralesional immunotherapy with tuberculin purified protein derivative (PPD) for treating recalcitrant wart. In this randomized, placebo-controlled, double-blind clinical trial, a total of 69 patients with recalcitrant warts received either intralesional PPD antigen (n = 35) or intralesional saline (n = 34) for six times at 2-week intervals. A third group of candidates for cryotherapy (n = 33) was also included. The decrease in lesion size (good: complete response, intermediate: 50-99% improvement, poor: cryotherapy patients, respectively (PPD versus placebo: p cryotherapy: p cryotherapy groups, respectively (p > 0.05). Intralesional immunotherapy with PPD antigen is highly effective and safe for treating recalcitrant warts. IRCT201407089844N3 in the Iranian Registry of Clinical Trials (IRCT).

  6. A draining concept for tunnels with the aim of optimizing their geothermal utilization; Concept de drainage des tunnels en vue d'une optimisation de l'utilisation geothermique (valorisation du potentiel geothermique des tunnels - Recherche d'optimisation)

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelm, J.

    2006-07-01

    Since almost 30 years, the geothermal potential of mountain water has been exploited in Swiss tunnels. The first known application was at the southern mouth of the St. Gotthard road tunnel, where the draining water was collected for heating a waiting-room in Airolo. The present report prepared for the Swiss Federal Office of Energy (SFOE) examines the possibilities for enhancing the efficiency and thus the potential of this geothermal application. They include: a) Reducing thermal losses by thermally insulating the water pipes along the tunnel. b) Increasing the usable quantity of water by providing additional drillings along the tunnel. c) Providing more than one water pipe, thus allowing to collect water of different temperatures in separate pipes. d) New technologies: add heat exchangers to tunnel construction elements in direct contact with the rocks, e.g. rock anchors, liners, concrete elements in the floor. The last chapter examines possible improvements for two large tunnels currently in project.

  7. Palladium electrodes for molecular tunnel junctions

    International Nuclear Information System (INIS)

    Chang Shuai; Sen Suman; Zhang Peiming; Gyarfas, Brett; Ashcroft, Brian; Lindsay, Stuart; Lefkowitz, Steven; Peng Hongbo

    2012-01-01

    Gold has been the metal of choice for research on molecular tunneling junctions, but it is incompatible with complementary metal–oxide–semiconductor fabrication because it forms deep level traps in silicon. Palladium electrodes do not contaminate silicon, and also give higher tunnel current signals in the molecular tunnel junctions that we have studied. The result is cleaner signals in a recognition-tunneling junction that recognizes the four natural DNA bases as well as 5-methyl cytosine, with no spurious background signals. More than 75% of all the recorded signal peaks indicate the base correctly. (paper)

  8. Femtosecond tunneling response of surface plasmon polaritons

    DEFF Research Database (Denmark)

    Keil, Ulrich Dieter Felix; Ha, Taekjip; Jensen, Jacob Riis

    1998-01-01

    We obtain femtosecond (200 fs) time resolution using a scanning tunneling microscope on surface plasmon polaritons (SPPs) generated by two 100 fs laser beams in total internal reflection geometry. The tunneling gap dependence of the signal clearly indicates the tunneling origin of the signal...... and suggests that nanometer spatial resolution can be obtained together with femtosecond temporal resolution. This fast response, in contrast to the picosecond decay time of SPPs revealed by differential reflectivity measurements, can be attributed to a coherent superposition of SPPs rectified at the tunneling...... junction. (C) 1998 American Institute of Physics. [S0003-6951(98)02223-2]....

  9. PUREX Storage Tunnels dangerous waste permit application

    International Nuclear Information System (INIS)

    1991-12-01

    The PUREX Storage Tunnels are a mixed waste storage unit consisting of two underground railroad tunnels: Tunnel Number 1 designated 218-E-14 and Tunnel Number 2 designated 218-E-15. The two tunnels are connected by rail to the PUREX Plant and combine to provide storage space for 48 railroad cars (railcars). The PUREX Storage Tunnels provide a long-term storage location for equipment removed from the PUREX Plant. Transfers into the PUREX Storage Tunnels are made on an as-needed basis. Radioactively contaminated equipment is loaded on railcars and remotely transferred by rail into the PUREX Storage Tunnels. Railcars act as both a transport means and a storage platform for equipment placed into the tunnels. This report consists of part A and part B. Part A reports on amounts and locations of the mixed water. Part B permit application consists of the following: Facility Description and General Provisions; Waste Characteristics; Process Information; Groundwater Monitoring; Procedures to Prevent Hazards; Contingency Plan; Personnel Training; Exposure Information Report

  10. Probing spin-polarized tunneling at high bias and temperature with a magnetic tunnel transistor

    NARCIS (Netherlands)

    Park, B.G.; Banerjee, T.; Min, B.C.; Sanderink, Johannes G.M.; Lodder, J.C.; Jansen, R.

    2005-01-01

    The magnetic tunnel transistor (MTT) is a three terminal hybrid device that consists of a tunnel emitter, a ferromagnetic (FM) base, and a semiconductor collector. In the MTT with a FM emitter and a single FM base, spin-polarized hot electrons are injected into the base by tunneling. After

  11. Resonant tunneling via spin-polarized barrier states in a magnetic tunnel junction

    NARCIS (Netherlands)

    Jansen, R.; Lodder, J.C.

    2000-01-01

    Resonant tunneling through states in the barrier of a magnetic tunnel junction has been analyzed theoretically for the case of a spin-polarized density of barrier states. It is shown that for highly spin-polarized barrier states, the magnetoresistance due to resonant tunneling is enhanced compared

  12. Analytical study of the effects of wind tunnel turbulence on turbofan rotor noise. [NASA Ames 40 by 80 foot wind tunnel

    Science.gov (United States)

    Gliebe, P. R.; Kerschen, E. J.

    1979-01-01

    The influence of tunnel turbulence on turbofan rotor noise was carried out to evaluate the effectiveness of the NASA Ames 40 by 80 foot tunnel in simulating flight levels of fan noise. A previously developed theory for predicting rotor/turbulence interaction noise was refined and extended to include first-order effects of inlet turbulence anisotropy. This theory was then verified by carrying out extensive data/theory comparisons. The resulting model computer program was then employed to carry out a parametric study of the effects of fan size, blade number, and operating line on rotor/turbulence noise for outdoor test stand. NASA Ames wind tunnel, and flight inlet turbulence conditions. A major result of this study is that although wind tunnel rotor/turbulence noise levels are not as low as flight levels they are substantially lower than the outdoor test stand levels and do not mask other sources of fan noise.

  13. Wrist immobilization after carpal tunnel release: a prospective study.

    Science.gov (United States)

    Martins, Roberto S; Siqueira, Mario G; Simplício, Hougelli

    2006-09-01

    This prospective study evaluates the possible advantages of wrist immobilization after open carpal tunnel release comparing the results of two weeks immobilization and no immobilization. Fifty two patients with idiopathic carpal tunnel syndrome were randomly selected in two groups after open carpal tunnel release. In one group (A, n=26) the patients wore a neutral-position wrist splint continuously for two weeks. In the other group (B, n=26) no wrist immobilization was used. Clinical assessment was done pre-operatively and at 2 weeks follow-up and included the two-point discrimination test at the second finger and two questionnaires as an outcome measurement of symptoms severity and intensity. All the patients presented improvement in the postoperative evaluations in the three analyzed parameters. There was no significant difference between the two groups for any of the outcome measurements at the final follow-up. We conclude that wrist immobilization in the immediate post-operative period have no advantages when compared with no immobilization in the end result of carpal tunnel release.

  14. Hand Shape and Carpal Tunnel Syndrome.

    Science.gov (United States)

    Neral, Mithun; Winger, Dan; Imbriglia, Joseph; Wollstein, Ronit

    2016-01-01

    The literature evaluating external anatomical measurements and carpal tunnel syndrome (CTS) remains inconclusive. The purpose of this study was to compare hand- shape measurements of patients with and without (CTS). A retrospective case - control study of participants with suspected CTS (male/female ratio of 0.69) was performed. Nerve conduction tests (NCT) defined 65 involved hands (CTS) and 73 control hands. The relationship between 3 different hand index ratios (measuring palm length and width) and CTS (defined by NCT) was evaluated using Generalized Estimating Equations model (GEE) with the binary outcome of CTS. Palmar Length/Palmar Width index had the strongest and negative association with CTS with greatest sensitivity and specificity to detect CTS. Hands with more square shape had increased tendency to be diagnosed with CTS. Hand indices that include the shape of the palm may help identify patients with greater likelihood of developing CTS for early screening and prevention.

  15. Carpal tunnel syndrome - Part II (treatment,

    Directory of Open Access Journals (Sweden)

    Michel Chammas

    2014-10-01

    Full Text Available The treatments for non-deficit forms of carpal tunnel syndrome (CTS are corticoid infiltration and/or a nighttime immobilization brace. Surgical treatment, which includes sectioning the retinaculum of the flexors (retinaculotomy, is indicated in cases of resistance to conservative treatment in deficit forms or, more frequently, in acute forms. In minimally invasive techniques (endoscopy and mini-open, and even though the learning curve is longer, it seems that functional recovery occurs earlier than in the classical surgery, but with identical long-term results. The choice depends on the surgeon, patient, severity, etiology and availability of material. The results are satisfactory in close to 90% of the cases. Recovery of strength requires four to six months after regression of the pain of pillar pain type. This surgery has the reputation of being benign and has a complication rate of 0.2–0.5%.

  16. Proceedings - Workshop on Materials Handling for Tunnel Construction

    Science.gov (United States)

    1977-08-01

    With the anticipated increases in tunnel construction in the next decade, greater demands will be made on transportation sytems to remove tunnel muck at rates consistent with tunnel excavation rates. This workshop discussed and noted that conventiona...

  17. Two-body tunnel transitions in a Mn 4 single-molecule magnet

    Science.gov (United States)

    Wernsdorfer, W.; Bhaduri, S.; Tiron, R.; Hendrickson, D. N.; Christou, G.

    2004-05-01

    The one-body tunnel picture of single-molecule magnets (SMMs) is not always sufficient to explain the measured tunnel transitions. An improvement to the picture is proposed by including also two-body tunnel transitions such as spin-spin cross-relaxation (SSCR) which are mediated by dipolar and weak superexchange interactions between molecules. A Mn 4 SMM is used as a model system. At certain external fields, SSCRs lead to additional quantum resonances which show up in hysteresis loop measurements as well-defined steps.

  18. Design of Rail Instrumentation for Wind Tunnel Sonic Boom Measurements and Computational-Experimental Comparisons

    Science.gov (United States)

    Cliff, Susan E.; Elmiligui, A.; Aftosmis, M.; Morgenstern, J.; Durston, D.; Thomas, S.

    2012-01-01

    An innovative pressure rail concept for wind tunnel sonic boom testing of modern aircraft configurations with very low overpressures was designed with an adjoint-based solution-adapted Cartesian grid method. The computational method requires accurate free-air calculations of a test article as well as solutions modeling the influence of rail and tunnel walls. Specialized grids for accurate Euler and Navier-Stokes sonic boom computations were used on several test articles including complete aircraft models with flow-through nacelles. The computed pressure signatures are compared with recent results from the NASA 9- x 7-foot Supersonic Wind Tunnel using the advanced rail design.

  19. Quantum tunnelling in condensed media

    CERN Document Server

    Kagan, Yu

    1992-01-01

    The essays in this book deal with of the problem of quantum tunnelling and related behavior of a microscopic or macroscopic system, which interacts strongly with an ""environment"" - this being some form of condensed matter. The ""system"" in question need not be physically distinct from its environment, but could, for example, be one particular degree of freedom on which attention is focussed, as in the case of the Josephson junction studied in several of the papers. This general problem has been studied in many hundreds, if not thousands, of articles in the literature, in contexts as diverse

  20. The value of MRI iniIdiopathic tarsal tunnel syndrome by measuring the cross-sectional area of tarsal tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Jung; Jeong, Yu Mi; Lee, Sheen Woo; Choi Seung; Kim, Jeong Ho; Park, Hong Gi [Gachon University, Gil Hospital, Incheon (Korea, Republic of)

    2015-03-15

    The purpose of this study was to evaluate the use of MRI as a diagnostic test in tarsal tunnel syndrome. There are no published reports with this aim and no diagnostic standard for idiopathic tarsal tunnel syndrome (TTS) using imaging modalities. We retrospectively searched our Picture Archiving and Communication System data and medical records to identify patients who were clinically and electomyographically diagnosed with idiopathic TTS without space-occupying lesion on MRI. Twenty five patients were included in the patient group. Another twenty-five patients who underwent ankle MRI for Achilles tendon disease were selected and included in the control group. Cross-sectional areas (CSA) of tarsal tunnel were manually measured independently by two radiologists who were blinded to clinical and surgical results, using three-dimensional reconstruction software in our hospital. Measurements were done on axial images at three levels (level 1, tibiotalar joint level; level 2, medial malleolar tip level; level 3, sustentaculum tali level). Patient and control group data were statistically analyzed by the Mann-Whitney test. The mean values of CSA at levels 1, 2, and 3 of the tarsal tunnel were 87.8 mm2, 98.2 mm2, and 105.2 mm2, respectively in the patient group; and 100.0 mm2, 113.8 mm2, and 127.9 mm2 in the control group, respectively, in reader 1; and 86.2 mm2, 97.6 mm2, 105.2 mm2, respectively in the patient group; and 99.7 mm2, 112.3 mm2, 124.4 mm2, respectively, in the control group, in reader 2. The mean CSA in the patient group was significantly less than that of the control group at all three levels (p < 0.05). Intra-class correlation coefficient value between reader 1 and reader 2 were 0.98 in group 1, and 0.97 in group 2, respectively. MRI can be helpful in the assessment of idiopathic tarsal tunnel syndrome. CSA measurements of tarsal tunnel at each level may predict TTS even though there are no space occupying lesions in the tarsal tunnel on MRI.

  1. Investigating hydraulic connections and the origin of water in a mine tunnel using stable isotopes and hydrographs

    International Nuclear Information System (INIS)

    Walton-Day, Katherine; Poeter, Eileen

    2009-01-01

    Turquoise Lake is a water-supply reservoir located north of the historic Sugarloaf Mining district near Leadville, Colorado, USA. Elevated water levels in the reservoir may increase flow of low-quality water from abandoned mine tunnels in the Sugarloaf District and degrade water quality downstream. The objective of this study was to understand the sources of water to Dinero mine drainage tunnel and evaluate whether or not there was a direct hydrologic connection between Dinero mine tunnel and Turquoise Lake from late 2002 to early 2008. This study utilized hydrograph data from nearby draining mine tunnels and the lake, and stable isotope (δ 18 O and δ 2 H) data from the lake, nearby draining mine tunnels, imported water, and springs to characterize water sources in the study area. Hydrograph results indicate that flow from the Dinero mine tunnel decreased 26% (2006) and 10% (2007) when lake elevation (above mean sea level) decreased below approximately 3004 m (approximately 9855 feet). Results of isotope analysis delineated two meteoric water lines in the study area. One line characterizes surface water and water imported to the study area from the western side of the Continental Divide. The other line characterizes groundwater including draining mine tunnels, springs, and seeps. Isotope mixing calculations indicate that water from Turquoise Lake or seasonal groundwater recharge from snowmelt represents approximately 10% or less of the water in Dinero mine tunnel. However, most of the water in Dinero mine tunnel is from deep groundwater having minimal isotopic variation. The asymmetric shape of the Dinero mine tunnel hydrograph may indicate that a limited mine pool exists behind a collapse in the tunnel and attenutates seasonal recharge. Alternatively, a conceptual model is presented (and supported with MODFLOW simulations) that is consistent with current and previous data collected in the study area, and illustrates how fluctuating lake levels change the local

  2. Featuring of transient tunneling current by voltage pulse and application to an electrochemical biosensor

    Science.gov (United States)

    Yun, Jun Yeon; Lee, Won Cheol; Choi, Seong Wook; Park, Young June

    2018-03-01

    We suggest a voltage pulse method for detecting the transient tunneling current component (faradaic current component) in a metal/redox-active monolayer/electrolyte system. After applying the pulse to the metal electrode, the capacitive current prevails; therefore, it is difficult to extract the tunneling current, which carries information on the biochemical reactions occurring between the biomarkers in the electrolyte and the self-assembled monolayer (SAM) as the probe peptide system. Instead of waiting until the capacitive current diminishes, and thereby, the tunneling current also decreases, we try to extract the tunneling current in an early stage of the pulse. The method is based on the observation that the capacitive current becomes symmetrized in the positive and negative pulses after introducing the SAM on the metal electrode. When the energy level of the redox molecule is higher than the Fermi level of the metal under zero-bias condition, the tunneling current in the negative pulse can be extracted by subtracting the capacitive current obtained from the positive pulse, where the tunneling current is neglected. The experiment conducted for detecting trypsin as a biomarker shows that the method enhances the sensitivity and the specific-to-nonspecific ratio of the sensor device in the case of the nonspecific protein-abundant electrolyte solution, as evinced by cyclic voltammetry measurements in comparison.

  3. Computational Wind Tunnel: A Design Tool for Rotorcraft, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Rotorcraft engineers traditionally use the wind tunnel to evaluate and finalize designs. Insufficient correlation between wind tunnel results and flight tests, have...

  4. Computational Wind Tunnel: A Design Tool for Rotorcraft Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Rotorcraft engineers traditionally use the wind tunnel to evaluate and finalize designs. Insufficient correlation between wind tunnel results and flight tests, have...

  5. Doped Josephson tunneling junction for use in a sensitive IR detector

    International Nuclear Information System (INIS)

    Fletcher, J.C.; Saffren, M.M.

    1975-01-01

    A superconductive tunneling device having a modified tunnel barrier capable of supporting Josephson tunneling current is provided. The tunnel barrier located between a pair of electrodes includes a molecular species which is capable of coupling incident radiation of a spectrum characteristic of the molecular species into the tunnel barrier. The coupled radiation modulates the known Josephson characteristics of the superconducting device. As a result of the present invention, a superconductive tunneling device can be tuned or made sensitive to a particular radiation associated with the dopant molecular species. The present invention is particularly useful in providing an improved infrared detector. The tunnel barrier region can be, for example, an oxide of an electrode or frozen gas. The molecular species can be intermixed with the barrier region such as the frozen gas or deposited as one or more layers of molecules on the barrier region. The deposited molecules of the molecular species are unbonded and capable of responding to a radiation characteristic of the molecules. Semi-conductor material can be utilized as the molecular species to provide an increased selective bandwidth response. Finally, appropriate detector equipment can be utilized to measure the modulation of any of the Josephson characteristics such as critical current, voltage steps, Lambe-Jaklevic peaks and plasma frequency. (auth)

  6. Bilayer insulator tunnel barriers for graphene-based vertical hot-electron transistors.

    Science.gov (United States)

    Vaziri, S; Belete, M; Dentoni Litta, E; Smith, A D; Lupina, G; Lemme, M C; Östling, M

    2015-08-14

    Vertical graphene-based device concepts that rely on quantum mechanical tunneling are intensely being discussed in the literature for applications in electronics and optoelectronics. In this work, the carrier transport mechanisms in semiconductor-insulator-graphene (SIG) capacitors are investigated with respect to their suitability as electron emitters in vertical graphene base transistors (GBTs). Several dielectric materials as tunnel barriers are compared, including dielectric double layers. Using bilayer dielectrics, we experimentally demonstrate significant improvements in the electron injection current by promoting Fowler-Nordheim tunneling (FNT) and step tunneling (ST) while suppressing defect mediated carrier transport. High injected tunneling current densities approaching 10(3) A cm(-2) (limited by series resistance), and excellent current-voltage nonlinearity and asymmetry are achieved using a 1 nm thick high quality dielectric, thulium silicate (TmSiO), as the first insulator layer, and titanium dioxide (TiO2) as a high electron affinity second layer insulator. We also confirm the feasibility and effectiveness of our approach in a full GBT structure which shows dramatic improvement in the collector on-state current density with respect to the previously reported GBTs. The device design and the fabrication scheme have been selected with future CMOS process compatibility in mind. This work proposes a bilayer tunnel barrier approach as a promising candidate to be used in high performance vertical graphene-based tunneling devices.

  7. The role of ultrasonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome

    International Nuclear Information System (INIS)

    Yesildag, A.; Kutluhan, S.; Sengul, N.; Koyuncuoglu, H.R.; Oyar, O.; Guler, K.; Gulsoy, U.K.

    2004-01-01

    AIM: The aim of study was to assess the usefulness of ultrasonographic measurements of the median nerve in the diagnosis of carpal tunnel syndrome. MATERIALS AND METHODS: Eighty-six patients with carpal tunnel syndrome confirmed by electromyography and 45 asymptomatic controls were included in the study and underwent high-resolution ultrasonography of the wrists. The cross-sectional area and flattening ratio at the level of the pisiform bone of the proximal carpal tunnel were measured. Data from the patient group and control group were compared to determine the statistical significance. The accuracy of the ultrasonographic diagnostic criteria for carpal tunnel syndrome was evaluated using receiver-operating characteristic (ROC) analysis. RESULTS: One hundred and forty-eight wrists of 86 patients with carpal tunnel syndrome and 76 wrists of 45 control patients were examined. All measurements showed significant differences between patients and controls. Increased cross-sectional area of the median nerve was the most predictive measurement of carpal tunnel syndrome. Using the ROC curve, a cut-off value of >10.5 mm 2 at the level of pisiform bone provided a diagnostic sensitivity of 89% and specificity of 94.7% CONCLUSION: The ultrasonographic measurement of the median nerve cross-sectional area is a sensitive, specific and useful non-invasive method for the diagnosis of carpal tunnel syndrome

  8. Road tunnels safety according to European legislation

    Directory of Open Access Journals (Sweden)

    Fedor KÁLLAY

    2008-01-01

    Full Text Available The article deals with safety of European road tunnels in accordance with actual European legislation. Standards and recommendations of European Commission, PIARC and other professional bodies of the European Union define minimal technological requirements for equipment and operation of the tunnels in scope of Trans-European Road Network.

  9. Spin tunneling and manipulation in nanostructures.

    Science.gov (United States)

    Sherman, E Ya; Ban, Yue; Gulyaev, L V; Khomitsky, D V

    2012-09-01

    The results for joint effects of tunneling and spin-orbit coupling on spin dynamics in nanostructures are presented for systems with discrete and continuous spectra. We demonstrate that tunneling plays the crucial role in the spin dynamics and the abilities of spin manipulation by external electric field. This result can be important for design of nanostructures-based spintronics devices.

  10. A Supermagnetic Tunnel Full of Subatomic Action

    CERN Multimedia

    2008-01-01

    Last year, before the gigantic hadron supercollider at CERN research facility was installed underground, a photographer captured this picture of a 1,950 metric ton tunnel containing giant magnets that will be placed in a tunnel and kept at near-zero temperatures.

  11. Tunneling of electrons through semiconductor superlattices

    Indian Academy of Sciences (India)

    Unknown

    Tunneling of electrons through semiconductor superlattices. C L ROY. Department of Physics and Meteorology, Indian Institute of Technology, Kharagpur 721 302, India. Abstract. The purpose of the present paper is to report a study of tunneling of electrons through semicon- ductor superlattices (SSL); specially, we have ...

  12. Role of Wind Tunnels in Aircraft Design

    Indian Academy of Sciences (India)

    Wind tunnel is an aerodynamic test facility. It is mostly used to study flow patterns around bodies and measure aerodynamic forces on them. The bodies (called models) are usually scaled down but geometrically similar versions of bodies of interest like an airplane or an automobile. The results from wind tunnel tests can be ...

  13. Energy saving in tunnel entrance lighting.

    NARCIS (Netherlands)

    Schreuder, D.A. & Swart, L.

    1993-01-01

    Tunnel entrances may present themselves during the day as a "black hole" in which no details can be perceived. In order to ensure safe and comfortable driving at high speeds, the entrance zone must be lit to a high luminance level. Modern tunnel lighting technology is focused on two aspects:

  14. Transport of dangerous goods through road tunnels

    DEFF Research Database (Denmark)

    Jørgensen, N O; Lacroix, Didier; Amundsen, F.H.

    1999-01-01

    A paper which describes the work of an OECD research group. The group has suggested a grouping of dangerous materials, a quantitative risk assessment model and a decision support model which should allow tunnel operators to determine if a given material should be allowed throug a given tunnel...

  15. Time-resolved scanning tunnelling microscopy

    NARCIS (Netherlands)

    van Houselt, Arie; Zandvliet, Henricus J.W.

    2010-01-01

    Scanning tunneling microscopy has revolutionized our ability to image, study, and manipulate solid surfaces on the size scale of atoms. One important limitation of the scanning tunneling microscope (STM) is, however, its poor time resolution. Recording a standard image with a STM typically takes

  16. Critical issues concerning tunnel ventilation in the super conducting super collider ring tunnel

    International Nuclear Information System (INIS)

    Egilsrud, P.E.

    1989-01-01

    In this paper, the author discusses the problem of designing a ventilation system for the SSC Collider Ring Tunnel. The history of ventilation of tunnels is briefly reviewed and the types of systems used for ventilation of rail, transit and highway tunnels are described in detail. Next, the ventilation system prepared for the Collider Ring Tunnel in the RTK conceptual conventional design report is described. The author questions this design from a safety and practical standpoint. He offers several other solutions which provided a more powerful system for emergencies. One supplies fresh outside air uniformly along the tunnel length. All suggested systems increase costs over the RTK proposed system. The possible problem of troublesome condensation forming on equipment in the tunnel and tunnel walls in hot, humid weather is also a major concern. 5 figs

  17. In situ stresses in rock masses: methodology for its study in tunnel projects in Spain

    International Nuclear Information System (INIS)

    Madirolas Perez, G.; Perucho Martinez, A.

    2014-01-01

    In situ stress is one of the main factors to be taken into account in the design of tunnels, as it can cause inadmissible stresses and strains leading to high deviations in the budgets. For that reason, the stress state is directly introduced into the numerical models used for the design of tunnels. In Spain, although several tunnels have been carried out with an important overburden in tectonically relevant zones, a quantitative determination of the stresses has not been usually included in civil work projects. Therefore, it is considered necessary to implement a routine procedure of study of civil work projects involving tunnels excavated in rock, and a new detailed methodology is proposed. The challenge is that project managers, who face works in which stresses may play a determinant role, may have a practical reference enabling them to optimize available resources and to include the real stress information in the design of underground works. (Author)

  18. Temporary closure of the tunnel

    CERN Multimedia

    Relations with the Host States Service

    2005-01-01

    Owing to major maintenance work, the tunnel linking the various parts of the CERN site will be closed from Monday 4 July to Sunday 24 July 2005 The Host State authorities have given authorisation for persons employed by CERN or the Institutes to travel and for goods belonging to these entities to be transported between the various parts of the site via Gate E (Charles de Gaulle) while this work is being carried out, subject to strict compliance with the Rules for the Use of the Tunnel (see http://dsu.web.cern.ch/dsu/dsum/hsr/DOCUMENTS/8200980415.pdf). Gate E will thus be open between 7.00 a.m. and 7.00 p.m. from Monday to Friday during the period concerned. The rules governing the use of Gate E to enter the Meyrin site between 7.30 a.m. and 9.00 a.m. or to leave the site between 5.00 p.m. and 6.30 p.m. (see http://dsu.web.cern.ch/dsu/dsum/hsr/DOCUMENTS/12222_041027.pdf)) will remain unaffected by this temporary authorisation. Relations with the Host States Service and TS-FM Group

  19. Tunneling Anomalous and Spin Hall Effects.

    Science.gov (United States)

    Matos-Abiague, A; Fabian, J

    2015-07-31

    We predict, theoretically, the existence of the anomalous Hall effect when a tunneling current flows through a tunnel junction in which only one of the electrodes is magnetic. The interfacial spin-orbit coupling present in the barrier region induces a spin-dependent momentum filtering in the directions perpendicular to the tunneling current, resulting in a skew tunneling even in the absence of impurities. This produces an anomalous Hall conductance and spin Hall currents in the nonmagnetic electrode when a bias voltage is applied across the tunneling heterojunction. If the barrier is composed of a noncentrosymmetric material, the anomalous Hall conductance and spin Hall currents become anisotropic with respect to both the magnetization and crystallographic directions, allowing us to separate this interfacial phenomenon from the bulk anomalous and spin Hall contributions. The proposed effect should be useful for proving and quantifying the interfacial spin-orbit fields in metallic and metal-semiconductor systems.

  20. High Surface Area Tunnels in Hexagonal WO₃.

    Science.gov (United States)

    Sun, Wanmei; Yeung, Michael T; Lech, Andrew T; Lin, Cheng-Wei; Lee, Chain; Li, Tianqi; Duan, Xiangfeng; Zhou, Jun; Kaner, Richard B

    2015-07-08

    High surface area in h-WO3 has been verified from the intracrystalline tunnels. This bottom-up approach differs from conventional templating-type methods. The 3.67 Å diameter tunnels are characterized by low-pressure CO2 adsorption isotherms with nonlocal density functional theory fitting, transmission electron microscopy, and thermal gravimetric analysis. These open and rigid tunnels absorb H(+) and Li(+), but not Na(+) in aqueous electrolytes without inducing a phase transformation, accessing both internal and external active sites. Moreover, these tunnel structures demonstrate high specific pseudocapacitance and good stability in an H2SO4 aqueous electrolyte. Thus, the high surface area created from 3.67 Å diameter tunnels in h-WO3 shows potential applications in electrochemical energy storage, selective ion transfer, and selective gas adsorption.

  1. Fire safety assessment of tunnel structures

    DEFF Research Database (Denmark)

    Gkoumas, Konstantinos; Giuliani, Luisa; Petrini, Francesco

    2011-01-01

    for upgrading fire safety provisions and tunnel management are also important for existing tunnels. In this study, following a brief introduction of issues regarding the above mentioned aspects, the structural performance of a steel rib for a tunnel infrastructure subject to fire is assessed by means...... durability provisions, commitment to environmental aspects, issues of sustainability and safety assurance, for their whole lifecycle. The design for safety of tunnel infrastructures is a multifaceted process, since there are many aspects that need to be accounted for, regarding different aspects (e.......g. structural and non structural, organizational, human behavior). This is even more truth for the fire safety design of such structures. Fire safety in tunnels is challenging because of the particular environment, bearing in mind also that a fire can occur in different phases of the tunnel’s lifecycle. Plans...

  2. Wind Tunnel Modeling Of Wind Flow Over Complex Terrain

    Science.gov (United States)

    Banks, D.; Cochran, B.

    2010-12-01

    This presentation will describe the finding of an atmospheric boundary layer (ABL) wind tunnel study conducted as part of the Bolund Experiment. This experiment was sponsored by Risø DTU (National Laboratory for Sustainable Energy, Technical University of Denmark) during the fall of 2009 to enable a blind comparison of various air flow models in an attempt to validate their performance in predicting airflow over complex terrain. Bohlund hill sits 12 m above the water level at the end of a narrow isthmus. The island features a steep escarpment on one side, over which the airflow can be expected to separate. The island was equipped with several anemometer towers, and the approach flow over the water was well characterized. This study was one of only two only physical model studies included in the blind model comparison, the other being a water plume study. The remainder were computational fluid dynamics (CFD) simulations, including both RANS and LES. Physical modeling of air flow over topographical features has been used since the middle of the 20th century, and the methods required are well understood and well documented. Several books have been written describing how to properly perform ABL wind tunnel studies, including ASCE manual of engineering practice 67. Boundary layer wind tunnel tests are the only modelling method deemed acceptable in ASCE 7-10, the most recent edition of the American Society of Civil Engineers standard that provides wind loads for buildings and other structures for buildings codes across the US. Since the 1970’s, most tall structures undergo testing in a boundary layer wind tunnel to accurately determine the wind induced loading. When compared to CFD, the US EPA considers a properly executed wind tunnel study to be equivalent to a CFD model with infinitesimal grid resolution and near infinite memory. One key reason for this widespread acceptance is that properly executed ABL wind tunnel studies will accurately simulate flow separation

  3. Enhanced expression of Wnt9a in the flexor tenosynovium in idiopathic carpal tunnel syndrome.

    Science.gov (United States)

    Yamanaka, Yoshiaki; Menuki, Kunitaka; Zenke, Yukichi; Hirasawa, Hideyuki; Sakai, Akinori

    2015-10-01

    This study aimed to clarify the association between abnormal Wnt signaling and the cause of idiopathic carpal tunnel syndrome (ICTS) and whether an association exists between Wnt signaling and cell proliferation in the flexor tenosynovium. The subjects included nine patients with ICTS; the controls were nine patients with distal radius fractures without any symptoms of carpal tunnel syndrome. We extracted mRNA from the flexor tenosynovium and compared the expression levels of genes encoding 17 types of Wnt in both subjects and controls via quantitative real-time polymerase chain reaction (PCR). Expression levels of factors involved in cell proliferation, such as estrogen-responsive finger protein, epidermal growth factor receptor, heparin binding-epidermal growth factor-like growth factor, insulin-like growth factor-1, and vascular endothelial growth factor (VEGF) were also measured using quantitative real-time PCR. In addition, we compared the Wnt and MIB-1 protein expression levels to clarify the effect of Wnt on cell proliferation. Quantitative real-time PCR revealed significantly greater expression of the gene encoding Wnt9a in subjects with ICTS than in controls and also revealed a positive correlation between the expression of genes encoding Wnt9a and VEGF in subjects with ICTS. Quantitative evaluation using immunohistochemical staining also indicated more marked Wnt9a expression in subjects than in controls. However, there was no relationship between the expression of Wnt9a and the cell proliferation index MIB-1. These results indicate that Wnt9a expression is enhanced in ICTS and that Wnt9a may be involved in VEGF expression in ICTS. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  4. The design of models for cryogenic wind tunnels. [mechanical properties and loads

    Science.gov (United States)

    Gillespie, V. P.

    1977-01-01

    Factors to be considered in the design and fabrication of models for cryogenic wind tunnels include high model loads imposed by the high operating pressures, the mechanical and thermodynamic properties of materials in low temperature environments, and the combination of aerodynamic loads with the thermal environment. Candidate materials are being investigated to establish criteria for cryogenic wind tunnel models and their installation. Data acquired from these tests will be provided to users of the National Transonic Facility.

  5. A Historical Evaluation of the U16a Tunnel, Nevada National Security Site, Nye County, Nevada Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Roberrt C. [Desert Research Inst. (DRI), Reno, NV (United States); Drollinger, Harold [Desert Research Inst. (DRI), Reno, NV (United States)

    2013-06-01

    This report presents a historical evaluation of the U16a Tunnel on the Nevada National Security Site in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency. The U16a Tunnel was used for underground nuclear weapons effects tests in Shoshone Mountain in Area 16 of the Nevada National Security Site. Six nuclear tests were conducted in the U16a Tunnel from 1962 to 1971. These tests are Marshmallow, Gum Drop, Double Play, Ming Vase, Diamond Dust, and Diamond Mine. The U.S. Department of Defense Threat Reduction Agency, with participation from Lawrence Livermore National Laboratory and Las Alamos National Laboratory, sponsored the tests. Fifteen high explosives tests were also conducted at the tunnel. Two were calibration tests during nuclear testing and the remaining were U.S. Department of Defense, Defense Threat Reduction Agency tunnel defeat tests. The U16a Tunnel complex is on the top and slopes of Shoshone Mountain, encompassing an area of approximately 16.7 hectares (41.1 acres). Major modifications to the landscape are a result of three principal activities, road construction and maintenance, mining activities related to development of the tunnel complex, and site preparation for activities related to testing. Forty-seven cultural features were recorded at the portal and on the slopes of Shoshone Mountain. At the portal area, features relate to the mining, construction, testing, and general every day operational support activities within the tunnel. These include concrete foundations for buildings, equipment pads, and rail lines. Features on the slopes above the tunnel relate to tunnel ventilation, borehole drilling, and data recording. Feature types include soil-covered bunkers, concrete foundations, instrument cable holes, drill holes, and ventilation shafts. The U16

  6. A Historical Evaluation of the U16a Tunnel, Nevada National Security Site, Nye County, Nevada Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Robert C. [Desert Research Inst. (DRI), Reno, NV (United States); Drollinger, Harold [Desert Research Inst. (DRI), Reno, NV (United States); Bullard, Thomas F. [Desert Research Inst. (DRI), Reno, NV (United States); Ashbaugh, Laurence J. [Desert Research Inst. (DRI), Reno, NV (United States); Griffin, Wayne R. [Desert Research Inst. (DRI), Reno, NV (United States)

    2013-01-01

    This report presents a historical evaluation of the U16a Tunnel on the Nevada National Security Site in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency. The U16a Tunnel was used for underground nuclear weapons effects tests in Shoshone Mountain in Area 16 of the Nevada National Security Site. Six nuclear tests were conducted in the U16a Tunnel from 1962 to 1971. These tests are Marshmallow, Gum Drop, Double Play, Ming Vase, Diamond Dust, and Diamond Mine. The U.S. Department of Defense Threat Reduction Agency, with participation from Lawrence Livermore National Laboratory and Las Alamos National Laboratory, sponsored the tests. Fifteen high explosives tests were also conducted at the tunnel. Two were calibration tests during nuclear testing and the remaining were U.S. Department of Defense, Defense Threat Reduction Agency tunnel defeat tests. The U16a Tunnel complex is on the top and slopes of Shoshone Mountain, encompassing an area of approximately 16.7 hectares (41.1 acres). Major modifications to the landscape are a result of three principal activities, road construction and maintenance, mining activities related to development of the tunnel complex, and site preparation for activities related to testing. Forty-seven cultural features were recorded at the portal and on the slopes of Shoshone Mountain. At the portal area, features relate to the mining, construction, testing, and general every day operational support activities within the tunnel. These include concrete foundations for buildings, equipment pads, and rail lines. Features on the slopes above the tunnel relate to tunnel ventilation, borehole drilling, and data recording. Feature types include soil-covered bunkers, concrete foundations, instrument cable holes, drill holes, and ventilation shafts. The U16

  7. Wind tunnel tests of a free yawing downwind wind turbine

    DEFF Research Database (Denmark)

    Verelst, David Robert; Larsen, Torben J.; van Wingerden, J.W.

    2012-01-01

    During February and April 2012 a series of wind tunnel tests were performed at the TU Delft Open Jet Facility (OJF) with a three bladed downwind wind turbine and a rotor radius of 0.8 meters. The setup includes an off the shelf three bladed hub, nacelle and generator on which relatively flexible ...... in free yawing conditions. Further, the effect of the tower shadow passage on the blade flapwise strain measurement is evaluated. Finally, data from the experiment is compared with preliminary simulations using DTU Wind Energy's aeroelastic simulation program HAWC2.......During February and April 2012 a series of wind tunnel tests were performed at the TU Delft Open Jet Facility (OJF) with a three bladed downwind wind turbine and a rotor radius of 0.8 meters. The setup includes an off the shelf three bladed hub, nacelle and generator on which relatively flexible...

  8. Plasmodesmata: intercellular tunnels facilitating transport of macromolecules in plants.

    Science.gov (United States)

    Kragler, Friedrich

    2013-04-01

    In plants, intercellular structures named plasmodesmata (PD) form a continuous cytoplasmic network between neighboring cells. PD pores provide channels for intercellular symplasmic (cell-to-cell) transport throughout most tissues of the plant body. Cell-defining proteins, such as transcription factors, and regulatory non-coding sequences, such as short interfering RNA, micro RNA, protein-encoding messenger RNAs, viroids, and viral RNA/DNA genomes move via PD channels to adjacent cells. PD-mediated intercellular transport of macromolecules is a regulated process depending on the tissue, developmental stage, and nature of the transported macromolecule. In this review, PD channels and their similarity to tunneling nanotubes present in animals are highlighted. In addition, homeodomain protein movement and cellular components regulating transport are discussed.

  9. Outbreak epidemiologically linked with a composite product of beef, mechanically separated chicken and textured vegetable protein contaminated with multiple serotypes of Salmonella enterica including multidrug-resistant Infantis, California 2016.

    Science.gov (United States)

    Hutchinson, J A; Wheeler, C; Mohle-Boetani, J C

    2018-03-01

    A salmonellosis outbreak occurred at a California prison in April and May 2016. In a cohort study of 371 inmates, persons who consumed dishes from the prison kitchen made from ground meat had a higher attack rate (15%) than those who did not (4%) (risk ratio 3.4, 95% CI 1.1-10.6). The ground meat product was composed exclusively of beef, mechanically separated chicken (MSC) and textured vegetable protein; eight of eight lots of the product collected from the prison and processing facility were contaminated with Salmonella enterica of eight serotypes and 17 distinct PFGE patterns, including multidrug-resistant S. Infantis. Either the MSC or the beef could have been the source of the particular strains of S. enterica isolated from patients or the product. The microbiological evidence is most consistent with MSC as the source of the high levels of S. enterica in the epidemiologically linked meat product. Our findings contribute to the growing body of evidence about the hazard posed by the use of products containing raw mechanically separated poultry in kitchens in institutions.

  10. Vibrational nonadiabaticity and tunneling effects in transition state theory

    International Nuclear Information System (INIS)

    Marcus, R.A.

    1979-01-01

    The usual quantum mechanical derivation of transition state theory is a statistical one (a quasi-equilibrium is assumed) or dynamical. The typical dynamical one defines a set of internal states and assumes vibrational adiabaticity. Effects of nonadiabaticity before and after the transition state are included in the present derivation, assuming a classical treatment of the reaction coordinate. The relation to a dynamical derivation of classical mechanical transition state theory is described, and tunneling effects are considered

  11. Flight costs and fuel composition of a bird migrating in a wind-tunnel

    NARCIS (Netherlands)

    Klaassen, M.R.J.; Kvist, A.; Lindström, A.

    2000-01-01

    We studied the energy and protein balance of a Thrush Nightingale Luscinia luscinia, a small long-distance migrant, during repeated 12-hr long Eights in a wind tunnel and during subsequent two-day fueling periods. From the energy budgets we estimated the power requirements for migratory flight in

  12. The Escherichia coli O157:H7 cattle immunoproteome includes outer membrane protein A (OmpA), a modulator of adherence to bovine rectoanal junction squamous epithelial (RSE) cells

    Science.gov (United States)

    Building on previous studies, we defined the repertoire of proteins comprising the antigenome of Escherichia coli (E. coli) O157 cultured in Dulbecco's Modified Eagles Medium (DMEM) supplemented with norepinephrine (NE; O157 protein-antigenome), a beta-adrenergic hormone that regulates E. coli O157 ...

  13. Josephson tunnel junction microwave attenuator

    DEFF Research Database (Denmark)

    Koshelets, V. P.; Shitov, S. V.; Shchukin, A. V.

    1993-01-01

    A new element for superconducting electronic circuitry-a variable attenuator-has been proposed, designed, and successfully tested. The principle of operation is based on the change in the microwave impedance of a superconductor-insulator-superconductor (SIS) Josephson tunnel junction when dc biased...... at different points in the current-voltage characteristic. Both numerical calculations based on the Tien-Gordon theory and 70-GHz microwave experiments have confirmed the wide dynamic range (more than 15-dB attenuation for one stage) and the low insertion loss in the ''open'' state. The performance of a fully...... integrated submillimeter receiver circuit which comprises a flux-flow oscillator (FFO) as local oscillator, a superconducting variable attenuator, and a microwave SIS detector with tuned-out capacitance is also reported....

  14. Homoepitaxial graphene tunnel barriers for spin transport

    Directory of Open Access Journals (Sweden)

    Adam L. Friedman

    2016-05-01

    Full Text Available Tunnel barriers are key elements for both charge-and spin-based electronics, offering devices with reduced power consumption and new paradigms for information processing. Such devices require mating dissimilar materials, raising issues of heteroepitaxy, interface stability, and electronic states that severely complicate fabrication and compromise performance. Graphene is the perfect tunnel barrier. It is an insulator out-of-plane, possesses a defect-free, linear habit, and is impervious to interdiffusion. Nonetheless, true tunneling between two stacked graphene layers is not possible in environmental conditions usable for electronics applications. However, two stacked graphene layers can be decoupled using chemical functionalization. Here, we demonstrate that hydrogenation or fluorination of graphene can be used to create a tunnel barrier. We demonstrate successful tunneling by measuring non-linear IV curves and a weakly temperature dependent zero-bias resistance. We demonstrate lateral transport of spin currents in non-local spin-valve structures, and determine spin lifetimes with the non-local Hanle effect. We compare the results for hydrogenated and fluorinated tunnel and we discuss the possibility that ferromagnetic moments in the hydrogenated graphene tunnel barrier affect the spin transport of our devices.

  15. Rudolf Hermann, wind tunnels and aerodynamics

    Science.gov (United States)

    Lundquist, Charles A.; Coleman, Anne M.

    2008-04-01

    Rudolf Hermann was born on December 15, 1904 in Leipzig, Germany. He studied at the University of Leipzig and at the Aachen Institute of Technology. His involvement with wind tunnels began in 1934 when Professor Carl Wieselsberger engaged him to work at Aachen on the development of a supersonic wind tunnel. On January 6, 1936, Dr. Wernher von Braun visited Dr. Hermann to arrange for use of the Aachen supersonic wind tunnel for Army problems. On April 1, 1937, Dr. Hermann became Director of the Supersonic Wind Tunnel at the Army installation at Peenemunde. Results from the Aachen and Peenemunde wind tunnels were crucial in achieving aerodynamic stability for the A-4 rocket, later designated as the V-2. Plans to build a Mach 10 'hypersonic' wind tunnel facility at Kochel were accelerated after the Allied air raid on Peenemunde on August 17, 1943. Dr. Hermann was director of the new facility. Ignoring destruction orders from Hitler as WWII approached an end in Europe, Dr. Hermann and his associates hid documents and preserved wind tunnel components that were acquired by the advancing American forces. Dr. Hermann became a consultant to the Air Force at its Wright Field in November 1945. In 1951, he was named professor of Aeronautical Engineering at the University of Minnesota. In 1962, Dr. Hermann became the first Director of the Research Institute at the University of Alabama in Huntsville (UAH), a position he held until he retired in 1970.

  16. Topographic anatomy of the ulnar tunnel.

    Science.gov (United States)

    Gil, Young-Chun; Shin, Kang-Jae; Lee, Ju-Young; Hu, Kyung-Seok; Kim, Hee-Jin; Song, Wu-Chul; Koh, Ki-Seok

    2015-09-01

    The aim of this study was to clarify the definition of the anterior wall of the ulnar tunnel and to reveal the topographical characteristics of the various components of the ulnar tunnel. Twenty-two forearms from 11 embalmed cadavers (7 males, 4 females; mean age, 67.8 years) were carefully dissected. In all cases, the anterior wall of the ulnar tunnel comprised the hypothenar fascia, which originated from the tendon of the flexor carpi ulnaris muscle. The palmar carpal ligament, the distal extent of the antebrachial fascia, was located deep to the anterior wall and formed only the anterior boundary of the proximal hiatus of the ulnar tunnel. The hypothenar fascia was attached to the flexor retinaculum at 15.2 mm lateral to the pisiform bone. However, the palmar carpal ligament was attached to the flexor retinaculum just lateral to the ulnar artery; the distance between the attachment of the palmar carpal ligament and the pisiform bone was 8.7 mm. Anatomical variations potentially associated with ulnar nerve compression were observed. The accessory abductor digiti minimi muscle and the fibrous band crossing the ulnar nerve in the ulnar tunnel were found in 27 and 23 % of forearms, respectively. A more detailed description of the anterior wall of the ulnar tunnel than was previously available is presented herein, and topographic and metric data regarding each structure of the tunnel are reported.

  17. A Model for the Behavior of Magnetic Tunnel Junctions

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Bryan John [Iowa State Univ., Ames, IA (United States)

    2003-01-01

    A magnetic tunnel junction is a device that changes its electrical resistance with a change in an applied magnetic field. A typical junction consists of two magnetic electrodes separated by a nonmagnetic insulating layer. The magnetizations of the two electrodes can have two possible extreme configurations, parallel and antiparallel. The antiparallel configuration is observed to have the higher measured resistance and the parallel configuration has the lower resistance. To switch between these two configurations a magnetic field is applied to the device which is primarily used to change the orientation of the magnetization of one electrode usually called the free layer, although with sufficient high magnetic field the orientation of the magnetizations of both of the electrodes can be changed. The most commonly used models for describing and explaining the electronic behavior of tunnel junctions are the Simmons model and the Brinkman model. However, both of these models were designed for simple, spin independent tunneling. The Simmons model does not address the issue of applied magnetic fields nor does it address the form of the electronic band structure in the metallic electrodes, including the important factor of spin polarization. The Brinkman model is similar, the main difference between the two models being the shape of the tunneling barrier potential between the two electrodes. Therefore, the research conducted in this thesis has developed a new theoretical model that addresses these important issues starting from basic principles. The main features of the new model include: the development of equations for true spin dependent tunneling through the insulating barrier, the differences in the orientations of the electrode magnetizations on either side of the barrier, and the effects of the density of states function on the behavior of the junction. The present work has explored densities of states that are more realistic than the simplified free electron density

  18. Injection sealing of the TASS tunnel. Progress report

    International Nuclear Information System (INIS)

    Funehag, Johan

    2008-12-01

    SKB's disposal facility is planned to be located approx. 400-500 m deep and the demands of its water tightness will be very high. The plant will be located in relatively fault-free rock with limited discharge and sealing will be carried out by injection. Given the very fine cracks that need to be sealed and the strong desire to use an injection material which generate a leachate with a pH lower than 11, SKB performs studies of silica sol and cement-based mortar with low pH in order to be able to use these in the sealing works. In the sealing project a 100 m long tunnel is constructed, the TASS tunnel at a depth of 450 min at SKB's rock laboratory on Aespoe. This report includes the results obtained until September 2008. At this date the injection stages 1, 2, and half of stage 3 have been done and preparation for Stage 3 is ongoing. The tunnel has reached a length of 55.5 m and the results from leaching measurements exist for stage 2 (Section 10-34 m). Both cement-based mortar with low pH and silica sol has been used, but cement-based mortar has been used only in relatively small scale. The cement-based mortar is developed especially for the repository. Silica sol used a particle size of about 25 nm and accelerator in the form of sodium chloride. The limit for inward leakage in the tunnel is 1 l/min and 60 m tunnel. Groundwater pressure was found to be 3.0-3.5 MPa. Past results obtained from Stage 2 indicate that injection shields fulfil the rate requirement over a 23 meter distance. The control holes drilled in the screens have been used to gradually steer the injection and to demonstrate a direct sealing effect of the screens. A controllable gelation time is necessary for efficient and controllable injection. Used mixing procedure has been proven to work and intended gelation times have been achieved. The two cement-based mortar mixtures for crack injection used in the project are robust and have desirable properties. Design methodology linking borehole distance

  19. Spin- and energy-dependent tunneling through a single molecule with intramolecular spatial resolution.

    Science.gov (United States)

    Brede, Jens; Atodiresei, Nicolae; Kuck, Stefan; Lazić, Predrag; Caciuc, Vasile; Morikawa, Yoshitada; Hoffmann, Germar; Blügel, Stefan; Wiesendanger, Roland

    2010-07-23

    We investigate the spin- and energy-dependent tunneling through a single organic molecule (CoPc) adsorbed on a ferromagnetic Fe thin film, spatially resolved by low-temperature spin-polarized scanning tunneling microscopy. Interestingly, the metal ion as well as the organic ligand show a significant spin dependence of tunneling current flow. State-of-the-art ab initio calculations including also van der Waals interactions reveal a strong hybridization of molecular orbitals and substrate 3d states. The molecule is anionic due to a transfer of one electron, resulting in a nonmagnetic (S=0) state. Nevertheless, tunneling through the molecule exhibits a pronounced spin dependence due to spin-split molecule-surface hybrid states.

  20. Analytical study of the effects of wind tunnel turbulence on turbofan rotor noise

    Science.gov (United States)

    Gliebe, P. R.

    1980-01-01

    An analytical study of the effects of wind tunnel turbulence on turbofan rotor noise was carried out to evaluate the effectiveness of the NASA Ames 40 by 80-foot wind tunnel in simulating flight levels of fan noise. A previously developed theory for predicting rotor/turbulence interaction noise, refined and extended to include first-order effects of inlet turbulence anisotropy, was employed to carry out a parametric study of the effects of fan size, blade number, and operating line for outdoor test stand, NASA Ames wind tunnel, and flight inlet turbulence conditions. A major result of this study is that although wind tunnel rotor/turbulence noise levels are not as low as flight levels, they are substantially lower than the outdoor test stand levels and do not mask other sources of fan noise.

  1. On the flow of groundwater in closed tunnels. Generic hydrogeological modelling of nuclear waste repository, SFL 3-5

    International Nuclear Information System (INIS)

    Holmen, J.G.

    1997-06-01

    The purpose is to study the flow of groundwater in closed tunnels by use of mathematical models. The calculations were based on three dimensional models, presuming steady state conditions. The stochastic continuum approach was used for representation of a heterogeneous rock mass. The size of the calculated flow is given as a multiple of an unknown regional groundwater flow. The size of the flow in a tunnel has been studied, as regards: Direction of the regional groundwater flow, Tunnel length, width and conductivity; Heterogeneity of the surrounding rock mass; Flow barriers and encapsulation inside a tunnel. The study includes a model of the planned repository for nuclear waste (SFL 3-5). The flow through the tunnels is estimated for different scenarios. The stochastic continuum approach has been investigated, as regards the representation of a scale dependent heterogeneous conductivity. An analytical method is proposed for the scaling of measured conductivity values, the method is consistent with the stochastic continuum approach. Some general conclusions from the work are: The larger the amount of heterogeneity, the larger the expected flow; The effects of the heterogeneity will decrease with increased tunnel length; If the conductivity of the tunnel is smaller than a threshold value, the tunnel conductivity is the most important parameter; If the tunnel conductivity is large and the tunnel is long, the most important parameter is the direction of the regional flow; Given a heterogeneous rock mass, if the tunnel length is shorter than about 500 m, the heterogeneity will be an important parameter, for lengths shorter than about 250 m, probably the most important; The flow through an encapsulation surrounded by a flow barrier is mainly dependent on the conductivity of the barrier. 70 refs, 110 figs, 10 tabs

  2. On the flow of groundwater in closed tunnels. Generic hydrogeological modelling of nuclear waste repository, SFL 3-5

    Energy Technology Data Exchange (ETDEWEB)

    Holmen, J.G. [Uppsala Univ. (Sweden). Inst. of Earth Sciences]|[Golder Associates AB (Sweden)

    1997-06-01

    The purpose is to study the flow of groundwater in closed tunnels by use of mathematical models. The calculations were based on three dimensional models, presuming steady state conditions. The stochastic continuum approach was used for representation of a heterogeneous rock mass. The size of the calculated flow is given as a multiple of an unknown regional groundwater flow. The size of the flow in a tunnel has been studied, as regards: Direction of the regional groundwater flow, Tunnel length, width and conductivity; Heterogeneity of the surrounding rock mass; Flow barriers and encapsulation inside a tunnel. The study includes a model of the planned repository for nuclear waste (SFL 3-5). The flow through the tunnels is estimated for different scenarios. The stochastic continuum approach has been investigated, as regards the representation of a scale dependent heterogeneous conductivity. An analytical method is proposed for the scaling of measured conductivity values, the method is consistent with the stochastic continuum approach. Some general conclusions from the work are: The larger the amount of heterogeneity, the larger the expected flow; The effects of the heterogeneity will decrease with increased tunnel length; If the conductivity of the tunnel is smaller than a threshold value, the tunnel conductivity is the most important parameter; If the tunnel conductivity is large and the tunnel is long, the most important parameter is the direction of the regional flow; Given a heterogeneous rock mass, if the tunnel length is shorter than about 500 m, the heterogeneity will be an important parameter, for lengths shorter than about 250 m, probably the most important; The flow through an encapsulation surrounded by a flow barrier is mainly dependent on the conductivity of the barrier. 70 refs, 110 figs, 10 tabs.

  3. Tunneling spin injection into single layer graphene.

    Science.gov (United States)

    Han, Wei; Pi, K; McCreary, K M; Li, Yan; Wong, Jared J I; Swartz, A G; Kawakami, R K

    2010-10-15

    We achieve tunneling spin injection from Co into single layer graphene (SLG) using TiO₂ seeded MgO barriers. A nonlocal magnetoresistance (ΔR(NL)) of 130  Ω is observed at room temperature, which is the largest value observed in any material. Investigating ΔR(NL) vs SLG conductivity from the transparent to the tunneling contact regimes demonstrates the contrasting behaviors predicted by the drift-diffusion theory of spin transport. Furthermore, tunnel barriers reduce the contact-induced spin relaxation and are therefore important for future investigations of spin relaxation in graphene.

  4. Thermal stability of tunneling spin polarization

    International Nuclear Information System (INIS)

    Kant, C.H.; Kohlhepp, J.T.; Paluskar, P.V.; Swagten, H.J.M.; Jonge, W.J.M. de

    2005-01-01

    We present a study of the thermal stability of tunneling spin polarization in Al/AlOx/ferromagnet junctions based on the spin-polarized tunneling technique, in which the Zeeman-split superconducting density of states in the Al electrode is used as a detector for the spin polarization. Thermal robustness of the polarization, which is of key importance for the performance of magnetic tunnel junction devices, is demonstrated for post-deposition anneal temperatures up to 500 o C with Co and Co 90 Fe 10 top electrodes, independent of the presence of an FeMn layer on top of the ferromagnet

  5. The Thames Tideway Tunnel (3/3)

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Lecture 3: Insight into a pioneering project at the cutting edge of engineering: the upgrade to London’s failing sewerage system. With a growing population and heavier rainfall, the River Thames is regularly polluted in breach of European Directive requirements. Two new storage and transfer tunnels will run up to 85m deep under the river and will intercept and divert sewer overflows to a treatment facility in east London. The challenges faced by constructing a tunnel project of this size under the river and through London’s historic urban environment will set a new UK record for this type of tunnelling.

  6. Tunneling decay of self-gravitating vortices

    Science.gov (United States)

    Dupuis, Éric; Gobeil, Yan; Lee, Bum-Hoon; Lee, Wonwoo; MacKenzie, Richard; Paranjape, Manu B.; Yajnik, Urjit A.; Yeom, Dong-han

    2018-01-01

    We investigate tunneling decay of false vortices in the presence of gravity, in which vortices are trapped in the false vacuum of a theory of scalar electrodynamics in three dimensions. The core of the vortex contains magnetic flux in the true vacuum, while outside the vortex is the appropriate topologically nontrivial false vacuum. We numerically obtain vortex solutions which are classically stable; however, they could decay via tunneling. To show this phenomenon, we construct the proper junction conditions in curved spacetime. We find that the tunneling exponent for the vortices is half that for Coleman-de Luccia bubbles and discuss possible future applications.

  7. Mechanical tunnel excavation in welded tuff

    International Nuclear Information System (INIS)

    Sperry, P.E.

    1991-01-01

    The Technical Review Board for the US high-level radioactive waste facility at Yucca Mountain has recommended maximum use of open-quotes the most modern mechanical excavation techniques...in order to reduce disturbance to the rock walls and to achieve greater economy of time and cost.close quotes Tunnels for the waste repository at Yucca Mountain can be economically constructed with mechanical excavation equipment. This paper presents the results of mechanical excavation of a tunnel in welded tuff, similar to the tuffs of Yucca Mountain. These results are projected to excavation of emplacement drifts in Yucca Mountain using a current state-of-the-art tunnel boring machine (TBM)

  8. Tunneling time distribution by means of Nelson's quantum ...

    Indian Academy of Sciences (India)

    We construct a tunneling time distribution by means of Nelson's quantum mechanics and investigate statistical properties of the tunneling time distribution. As a result, we find that the relationship between the average and the variance of the tunneling time shows 'wave-particle duality'. Keywords. Tunneling time distribution ...

  9. CONTINUOUS MAPPING OF TUNNEL WALLS IN A GNSS-DENIED ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    M. A. Chapman

    2016-06-01

    Full Text Available The need for reliable systems for capturing precise detail in tunnels has increased as the number of tunnels (e.g., for cars and trucks, trains, subways, mining and other infrastructure has increased and the age of these structures and, subsequent, deterioration has introduced structural degradations and eventual failures. Due to the hostile environments encountered in tunnels, mobile mapping systems are plagued with various problems such as loss of GNSS signals, drift of inertial measurements systems, low lighting conditions, dust and poor surface textures for feature identification and extraction. A tunnel mapping system using alternate sensors and algorithms that can deliver precise coordinates and feature attributes from surfaces along the entire tunnel path is presented. This system employs image bridging or visual odometry to estimate precise sensor positions and orientations. The fundamental concept is the use of image sequences to geometrically extend the control information in the absence of absolute positioning data sources. This is a non-trivial problem due to changes in scale, perceived resolution, image contrast and lack of salient features. The sensors employed include forward-looking high resolution digital frame cameras coupled with auxiliary light sources. In addition, a high frequency lidar system and a thermal imager are included to offer three dimensional point clouds of the tunnel walls along with thermal images for moisture detection. The mobile mapping system is equipped with an array of 16 cameras and light sources to capture the tunnel walls. Continuous images are produced using a semi-automated mosaicking process. Results of preliminary experimentation are presented to demonstrate the effectiveness of the system for the generation of seamless precise tunnel maps.

  10. Hawking radiation due to photon and gravitino tunneling

    International Nuclear Information System (INIS)

    Majhi, Bibhas Ranjan; Samanta, Saurav

    2010-01-01

    Applying the Hamilton-Jacobi method we investigate the tunneling of photon across the event horizon of a static spherically symmetric black hole. The necessity of the gauge condition on the photon field, to derive the semiclassical Hawking temperature, is explicitly shown. Also, the tunneling of photon and gravitino beyond this semiclassical approximation are presented separately. Quantum corrections of the action for both cases are found to be proportional to the semiclassical contribution. Modifications to the Hawking temperature and Bekenstein-Hawking area law are thereby obtained. Using this corrected temperature and Hawking's periodicity argument, the modified metric for the Schwarzschild black hole is given. This corrected version of the metric, up to h order is equivalent to the metric obtained by including one loop back reaction effect. Finally, the coefficient of the leading order correction of entropy is shown to be related to the trace anomaly.

  11. Circular polarization in a non-magnetic resonant tunneling device

    Directory of Open Access Journals (Sweden)

    Airey Robert

    2011-01-01

    Full Text Available Abstract We have investigated the polarization-resolved photoluminescence (PL in an asymmetric n-type GaAs/AlAs/GaAlAs resonant tunneling diode under magnetic field parallel to the tunnel current. The quantum well (QW PL presents strong circular polarization (values up to -70% at 19 T. The optical emission from GaAs contact layers shows evidence of highly spin-polarized two-dimensional electron and hole gases which affects the spin polarization of carriers in the QW. However, the circular polarization degree in the QW also depends on various other parameters, including the g-factors of the different layers, the density of carriers along the structure, and the Zeeman and Rashba effects.

  12. 14- by 22-Foot Subsonic Tunnel Laser Velocimeter Upgrade

    Science.gov (United States)

    Meyers, James F.; Lee, Joseph W.; Cavone, Angelo A.; Fletcher, Mark T.

    2012-01-01

    A long-focal length laser velocimeter constructed in the early 1980's was upgraded using current technology to improve usability, reliability and future serviceability. The original, free-space optics were replaced with a state-of-the-art fiber-optic subsystem which allowed most of the optics, including the laser, to be remote from the harsh tunnel environment. General purpose high-speed digitizers were incorporated in a standard modular data acquisition system, along with custom signal processing software executed on a desktop computer, served as the replacement for the signal processors. The resulting system increased optical sensitivity with real-time signal/data processing that produced measurement precisions exceeding those of the original system. Monte Carlo simulations, along with laboratory and wind tunnel investigations were used to determine system characteristics and measurement precision.

  13. Quantum tunneling radiation from self-dual black holes

    Energy Technology Data Exchange (ETDEWEB)

    Silva, C.A.S., E-mail: calex@fisica.ufc.br [Instituto Federal de Educação Ciência e Tecnologia da Paraíba (IFPB), Campus Campina Grande, Rua Tranquilino Coelho Lemos, 671, Jardim Dinamérica I (Brazil); Brito, F.A., E-mail: fabrito@df.ufcg.edu.br [Departamento de Física, Universidade Federal de Campina Grande, Caixa Postal 10071, 58109-970 Campina Grande, Paraíba (Brazil)

    2013-10-01

    Black holes are considered as objects that can reveal quantum aspects of spacetime. Loop Quantum Gravity (LQG) is a theory that propose a way to model the quantum spacetime behavior revealed by a black hole. One recent prediction of this theory is the existence of sub-Planckian black holes, which have the interesting property of self-duality. This property removes the black hole singularity and replaces it with another asymptotically flat region. In this work, we obtain the thermodynamical properties of this kind of black holes, called self-dual black holes, using the Hamilton–Jacobi version of the tunneling formalism. Moreover, using the tools of the tunneling approach, we investigate the emission spectrum of self-dual black holes, and investigate if some information about the black hole initial state can be recovered during the evaporation process. Back-reaction effects are included.

  14. Apparatus and method for large tunnel excavation in hard rock

    International Nuclear Information System (INIS)

    Altseimer, J.H.; Hanold, R.J.

    1975-01-01

    A tunneling machine is described for producing large tunnels in rock by progressive detachment of the tunnel core by thermal melting a boundary kerf into the tunnel face and simultaneously forming an initial tunnel wall support by deflecting the molten materials against the tunnel walls to provide, when solidified, a continuous liner; and fragmenting the tunnel core circumscribed by the kerf by thermal stress fracturing and in which the heat required for such operations is supplied by a compact nuclear reactor. (U.S.)

  15. Abu Dhabi's strategic tunnel enhancement programme: odour extraction system approaches.

    Science.gov (United States)

    Cowden, Scott; Witherspoon, Jay; Orakzai, Shahzad; Krause, T

    2012-01-01

    The Emirate of Abu Dhabi has experienced tremendous growth since the mid-1970s resulting in significant overloading of its existing sewerage system. Master planning determined that the best long-term wastewater collection and conveyance solution was construction of a deep tunnel sewer system. Implementation of this massive project faced numerous challenges, including the goal of no odours and limited odour control facilities. To accomplish this, the consultant team examined a unique approach of a single odour control system installed at the proposed downstream tunnel pumping station. Rigorous analysis utilising computer-based models confirmed the viability of this approach. However, other approaches including multiple satellite (localised or regional) odour extraction systems were considered. To better understand entrained air forces at vortex drops, and to confirm the preferred odour extraction approach, physical modelling of drop structures and overall tunnel system was implemented. Results and findings concluded that a regional odour extraction system approach was preferred over a single (centralised) extraction approach. This paper focuses on the process of selecting the preferred odour extraction approach and preliminary capacity sizing of regional systems.

  16. Correlations of Platooning Track Test and Wind Tunnel Data

    Energy Technology Data Exchange (ETDEWEB)

    Lammert, Michael P [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kelly, Kenneth J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Yanowitz, Janet [Ecoengineering

    2018-02-02

    In this report, the National Renewable Energy Laboratory analyzed results from multiple, independent truck platooning projects to compare and contrast track test results with wind tunnel test results conducted by Lawrence Livermore National Laboratory (LLNL). Some highlights from the report include compiled data, and results from four independent SAE J1321 full-size track test campaigns that were compared to LLNL wind tunnel testing results. All platooning scenarios tested demonstrated significant fuel savings with good correlation relative to following distances, but there are still unanswered questions and clear opportunities for system optimization. NOx emissions showed improvements from NREL tests in 2014 to Auburn tests in 2015 with respect to J1321 platooning track testing of Peloton system. NREL evaluated data from Volpe's Naturalistic Study of Truck Following Behavior, which showed minimal impact of naturalistic background platooning. We found significant correlation between multiple track studies, wind tunnel tests, and computational fluid dynamics, but also showed that there is more to learn regarding close formation and longer-distance effects. We also identified potential areas for further research and development, including development of advanced aerodynamic designs optimized for platooning, measurement of platoon system performance in traffic conditions, impact of vehicle lateral offsets on platooning performance, and characterization of the national potential for platooning based on fleet operational characteristics.

  17. Tunneling time, exit time and exit momentum in strong field tunnel ionization

    International Nuclear Information System (INIS)

    Teeny, Nicolas

    2016-01-01

    Tunnel ionization belongs to the fundamental processes of atomic physics. It is still an open question when does the electron tunnel ionize and how long is the duration of tunneling. In this work we solve the time-dependent Schroedinger equation in one and two dimensions and use ab initio quantum calculations in order to answer these questions. Additionally, we determine the exit momentum of the tunnel ionized electron from first principles. We find out results that are different from the assumptions of the commonly employed two-step model, which assumes that the electron ionizes at the instant of electric field maximum with a zero momentum. After determining the quantum final momentum distribution of tunnel ionized electrons we show that the two-step model fails to predict the correct final momentum. Accordingly we suggest how to correct the two-step model. Furthermore, we determine the instant at which tunnel ionization starts, which turns out to be different from the instant usually assumed. From determining the instant at which it is most probable for the electron to enter the tunneling barrier and the instant at which it exits we determine the most probable time spent under the barrier. Moreover, we apply a quantum clock approach in order to determine the duration of tunnel ionization. From the quantum clock we determine an average tunneling time which is different in magnitude and origin with respect to the most probable tunneling time. By defining a probability distribution of tunneling times using virtual detectors we relate both methods and explain the apparent discrepancy. The results found have in general an effect on the interpretation of experiments that measure the spectra of tunnel ionized electrons, and specifically on the calibration of the so called attoclock experiments, because models with imprecise assumptions are usually employed in order to interpret experimental results.

  18. Tunneling time, exit time and exit momentum in strong field tunnel ionization

    Energy Technology Data Exchange (ETDEWEB)

    Teeny, Nicolas

    2016-10-18

    Tunnel ionization belongs to the fundamental processes of atomic physics. It is still an open question when does the electron tunnel ionize and how long is the duration of tunneling. In this work we solve the time-dependent Schroedinger equation in one and two dimensions and use ab initio quantum calculations in order to answer these questions. Additionally, we determine the exit momentum of the tunnel ionized electron from first principles. We find out results that are different from the assumptions of the commonly employed two-step model, which assumes that the electron ionizes at the instant of electric field maximum with a zero momentum. After determining the quantum final momentum distribution of tunnel ionized electrons we show that the two-step model fails to predict the correct final momentum. Accordingly we suggest how to correct the two-step model. Furthermore, we determine the instant at which tunnel ionization starts, which turns out to be different from the instant usually assumed. From determining the instant at which it is most probable for the electron to enter the tunneling barrier and the instant at which it exits we determine the most probable time spent under the barrier. Moreover, we apply a quantum clock approach in order to determine the duration of tunnel ionization. From the quantum clock we determine an average tunneling time which is different in magnitude and origin with respect to the most probable tunneling time. By defining a probability distribution of tunneling times using virtual detectors we relate both methods and explain the apparent discrepancy. The results found have in general an effect on the interpretation of experiments that measure the spectra of tunnel ionized electrons, and specifically on the calibration of the so called attoclock experiments, because models with imprecise assumptions are usually employed in order to interpret experimental results.

  19. Reactive transport predictions for an Olkiluoto. Final repository tunnel unit

    International Nuclear Information System (INIS)

    Luukkonen, A.; Nordman, H.

    2007-09-01

    repository level. Calculations also predict the conversion of Na-montmorillonite to mixed (Na,Ca)-montmorillonite within the tunnel unit in 10,000-20,000 years from the start of the repository operations. This mineralogical change as well as salinity changes of infiltrating groundwater should affect the engineered barrier swelling pressures. However, pressure changes are not estimated in this study. However, there are significant uncertainties included in the calculations. The future climatic and geological events are likely not completely understood. Groundwater flow/diffusion rates within the backfilled tunnel are uncertain. Changes in material properties (homogeneity, alteration) with time should be estimated as well. (orig.)

  20. Quantum size effects on spin-tunneling time in a magnetic resonant tunneling diode

    OpenAIRE

    Saffarzadeh, Alireza; Daqiq, Reza

    2009-01-01

    We study theoretically the quantum size effects of a magnetic resonant tunneling diode (RTD) with a (Zn,Mn)Se dilute magnetic semiconductor layer on the spin-tunneling time and the spin polarization of the electrons. The results show that the spin-tunneling times may oscillate and a great difference between the tunneling time of the electrons with opposite spin directions can be obtained depending on the system parameters. We also study the effect of structural asymmetry which is related to t...

  1. Single-molecule spectroscopy of amino acids and peptides by recognition tunnelling

    Science.gov (United States)

    Zhao, Yanan; Ashcroft, Brian; Zhang, Peiming; Liu, Hao; Sen, Suman; Song, Weisi; Im, Jongone; Gyarfas, Brett; Manna, Saikat; Biswas, Sovan; Borges, Chad; Lindsay, Stuart

    2014-06-01

    The human proteome has millions of protein variants due to alternative RNA splicing and post-translational modifications, and variants that are related to diseases are frequently present in minute concentrations. For DNA and RNA, low concentrations can be amplified using the polymerase chain reaction, but there is no such reaction for proteins. Therefore, the development of single-molecule protein sequencing is a critical step in the search for protein biomarkers. Here, we show that single amino acids can be identified by trapping the molecules between two electrodes that are coated with a layer of recognition molecules, then measuring the electron tunnelling current across the junction. A given molecule can bind in more than one way in the junction, and we therefore use a machine-learning algorithm to distinguish between the sets of electronic `fingerprints' associated with each binding motif. With this recognition tunnelling technique, we are able to identify D and L enantiomers, a methylated amino acid, isobaric isomers and short peptides. The results suggest that direct electronic sequencing of single proteins could be possible by sequentially measuring the products of processive exopeptidase digestion, or by using a molecular motor to pull proteins through a tunnel junction integrated with a nanopore.

  2. Tunnel magnetoresistance in double spin filter junctions

    International Nuclear Information System (INIS)

    Saffarzadeh, Alireza

    2003-01-01

    We consider a new type of magnetic tunnel junction, which consists of two ferromagnetic tunnel barriers acting as spin filters (SFs), separated by a nonmagnetic metal (NM) layer. Using the transfer matrix method and the free-electron approximation, the dependence of the tunnel magnetoresistance (TMR) on the thickness of the central NM layer, bias voltage and temperature in the double SF junction are studied theoretically. It is shown that the TMR and electron-spin polarization in this structure can reach very large values under suitable conditions. The highest value of the TMR can reach 99%. By an appropriate choice of the thickness of the central NM layer, the degree of spin polarization in this structure will be higher than that of the single SF junctions. These results may be useful in designing future spin-polarized tunnelling devices

  3. Tunneling time in space fractional quantum mechanics

    Science.gov (United States)

    Hasan, Mohammad; Mandal, Bhabani Prasad

    2018-02-01

    We calculate the time taken by a wave packet to travel through a classically forbidden region of space in space fractional quantum mechanics. We obtain the close form expression of tunneling time from a rectangular barrier by stationary phase method. We show that tunneling time depends upon the width b of the barrier for b → ∞ and therefore Hartman effect doesn't exist in space fractional quantum mechanics. Interestingly we found that the tunneling time monotonically reduces with increasing b. The tunneling time is smaller in space fractional quantum mechanics as compared to the case of standard quantum mechanics. We recover the Hartman effect of standard quantum mechanics as a special case of space fractional quantum mechanics.

  4. A century of wind tunnels since Eiffel

    Science.gov (United States)

    Chanetz, Bruno

    2017-08-01

    Fly higher, faster, preserve the life of test pilots and passengers, many challenges faced by man since the dawn of the twentieth century, with aviation pioneers. Contemporary of the first aerial exploits, wind tunnels, artificially recreating conditions encountered during the flight, have powerfully contributed to the progress of aeronautics. But the use of wind tunnels is not limited to aviation. The research for better performance, coupled with concern for energy saving, encourages manufacturers of ground vehicles to perform aerodynamic tests. Buildings and bridge structures are also concerned. This article deals principally with the wind tunnels built at ONERA during the last century. Somme wind tunnels outside ONERA, even outside France, are also evocated when their characteristics do not exist at ONERA.

  5. LEP sees the end of the tunnel

    CERN Multimedia

    2002-01-01

    After 14 months, which have seen the removal of 30,000 tonnes of material from the tunnel, the LEP dismantling operation has now been completed. LHC installation, which will be subject to new safety rules, can go ahead.

  6. Roughcastle tunnel above an old mine

    Energy Technology Data Exchange (ETDEWEB)

    Sakalas, C.F.; Beadman, D.R.; Manning, S.R. [High-Point Rendel (United Kingdom)

    2002-06-01

    Construction of the 147 m long Roughcastle Tunnel, part of the Millennium Link connecting the Forth and Clyde canal and the Union canal at Falkirk, Scotland, provided an unusual challenge for designer and contractor alike. It overlays an unfilled, abandoned stoop-and pillar fireclay mine at shallow depth. Boreholes were drilled into the mine to ascertain the rock quality in the roof and pillars, and ultrasonic surveys carried to determine the condition of the workings to assess the risk, and the possible effect on the tunnel of a mine collapse during the tunnel's 120 year design life. The tunnel was successfully completed using a single pass sprayed concrete lining technique in a mixed face of stiff glacial till overlying Lower Coal Measures comprising interbedded sandstones, mudstones and coals. 4 photos.

  7. Dynamical quenching of tunneling in molecular magnets

    International Nuclear Information System (INIS)

    José Santander, María; Nunez, Alvaro S.; Roldán-Molina, A.; Troncoso, Roberto E.

    2015-01-01

    It is shown that a single molecular magnet placed in a rapidly oscillating magnetic field displays the phenomenon of quenching of tunneling processes. The results open a way to manipulate the quantum states of molecular magnets by means of radiation in the terahertz range. Our analysis separates the time evolution into slow and fast components thereby obtaining an effective theory for the slow dynamics. This effective theory presents quenching of the tunnel effect, in particular, stands out its difference with the so-called coherent destruction of tunneling. We support our prediction with numerical evidence based on an exact solution of Schrödinger's equation. - Highlights: • Single molecular magnets under rapidly oscillating magnetic fields is studied. • It is shown that this system displays the quenching of tunneling processes. • Our findings provide a control of quantum molecular magnets via terahertz radiation

  8. 7 x 10 Foot Wind Tunnel

    Data.gov (United States)

    Federal Laboratory Consortium — This wind tunnel is used for basic and applied research in aeromechanics on advanced and unique technology rotorcraft. It supports research on advanced concepts and...

  9. Dielectric Sensors Based on Electromagnetic Energy Tunneling

    Directory of Open Access Journals (Sweden)

    Omar Siddiqui

    2015-03-01

    Full Text Available We show that metallic wires embedded in narrow waveguide bends and channels demonstrate resonance behavior at specific frequencies. The electromagnetic energy at these resonances tunnels through the narrow waveguide channels with almost no propagation losses. Under the tunneling behavior, high-intensity electromagnetic fields are produced in the vicinity of the metallic wires. These intense field resonances can be exploited to build highly sensitive dielectric sensors. The sensor operation is explained with the help of full-wave simulations. A practical setup consisting of a 3D waveguide bend is presented to experimentally observe the tunneling phenomenon. The tunneling frequency is predicted by determining the input impedance minima through a variational formula based on the Green function of a probe-excited parallel plate waveguide.

  10. Teelt van vruchtgewassen in lage tunnels

    NARCIS (Netherlands)

    Wijk, van C.A.P.; Geven, C.G.M.

    1994-01-01

    Een aantal warmteminnende vruchtgewassen zijn beproefd in lage tunnels en vergeleken met onbedekte teelt en met kasteelt. Het betrof aubergine, paprika, peper en diverse typen meloen. Daar is courgette als vergelijkend gewas aan toegevoegd

  11. A critical examination of expansion tunnel performance

    Science.gov (United States)

    Miller, C. G.

    1978-01-01

    An experimental study of the performance of the expansion tunnel for various test gases and range of quiescent acceleration section and nozzle pressure, nozzle geometric area ratio, and nozzle axial station has been performed. Flow diagnostics used to examine expansion tunnel flow characteristics were time histories and profiles of pitot pressure and axial component of flow velocity. The purpose of this study was to determine experimentally what limitations might restrict predicted operational flexibility and the advantages and disadvantages of this mode of operation as compared to the expansion tube. Results are presented which demonstrate the expansion tunnel offers several advantages over the expansion tube, but the severity of the disadvantages of the tunnel makes the expansion tube mode of operation the more desirable for performing hypersonic-hypervelocity aerothermodynamic studies of proposed entry configurations.

  12. Computer graphic of LHC in the tunnel

    CERN Multimedia

    1996-01-01

    A computer-generated image of the LHC particle accelerator at CERN in the tunnel originally built for the LEP accelerator that was closed in 2000. The cross-section of an LHC superconducting dipole magnet is also seen.

  13. Low Speed Wind Tunnel Facility (LSWTF)

    Data.gov (United States)

    Federal Laboratory Consortium — Description: This facility consists of a large-scale, low-speed open-loop induction wind tunnel which has been modified to house a linear turbine cascade. A 125-hp...

  14. Proton tunnelling in intermolecular hydrogen bonds

    Energy Technology Data Exchange (ETDEWEB)

    Horsewill, A.J. [Nottingham Univ. (United Kingdom); Johnson, M.R. [Institut Max von Laue - Paul Langevin (ILL), 38 - Grenoble (France); Trommsdorff, H.P. [Grenoble-1 Univ., 38 (France)

    1997-04-01

    The wavefunctions of particles extend beyond the classically accessible regions of potential energy-surfaces (PES). A manifestation of this partial delocalization is the quantum-mechanical tunneling effect which enables a particle to escape from a metastable potential-well. Tunnelling is most important for the lightest atoms, so that the determination of its contribution to proton transfer, one of the most fundamental chemical reactions, is an important issue. QENS and NMR techniques have been employed to study the motion of protons in the hydrogen bond of benzoic-acid crystals, a system which has emerged as a particularly suitable model since proton transfer occurs in a near symmetric double-well potential. The influence of quantum tunnelling was revealed and investigated in these experiments. This work provides an experimental benchmark for theoretical descriptions of translational proton-tunnelling. (author). 7 refs.

  15. Pump apparatus including deconsolidator

    Energy Technology Data Exchange (ETDEWEB)

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  16. Detecting DNS Tunnels Using Character Frequency Analysis

    OpenAIRE

    Born, Kenton; Gustafson, David

    2010-01-01

    High-bandwidth covert channels pose significant risks to sensitive and proprietary information inside company networks. Domain Name System (DNS) tunnels provide a means to covertly infiltrate and exfiltrate large amounts of information passed network boundaries. This paper explores the possibility of detecting DNS tunnels by analyzing the unigram, bigram, and trigram character frequencies of domains in DNS queries and responses. It is empirically shown how domains follow Zipf's law in a simil...

  17. An epitaxial ferroelectric tunnel junction on silicon.

    Science.gov (United States)

    Li, Zhipeng; Guo, Xiao; Lu, Hui-Bin; Zhang, Zaoli; Song, Dongsheng; Cheng, Shaobo; Bosman, Michel; Zhu, Jing; Dong, Zhili; Zhu, Weiguang

    2014-11-12

    Epitaxially grown functional perovskites on silicon (001) and the ferroelectricity of a 3.2 nm thick BaTiO3 barrier layer are demonstrated. The polarization-switching-induced change in tunneling resistance is measured to be two orders of magnitude. The obtained results suggest the possibility of integrating ferroelectric tunnel junctions as binary data storage media in non-volatile memory cells on a silicon platform. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Numerical modeling of tunneling-induced seismicity

    Science.gov (United States)

    Rinaldi, Antonio Pio; Urpi, Luca

    2017-04-01

    Removal of rock mass in mining environment has been associated since long-time with seismic event of magnitude 3 and above, with the potential to cause damage to the infrastructures or even loss of human life. Although with similarities with mining, relatively unknown up to now are seismic events induced by tunneling. However with modern mechanized tunneling techniques, making possible to digging deeper and longer underground infrastructure, the risk is not negligible. As an example, the excavation of the 57km long Gotthard Base Tunnel has been associated more than hundred seismic events, with the largest one having magnitude of ML 2.4, damaging the tunnel infrastructures. For future scenario of deep geological storage of nuclear waste, tunneling will constitute the primary activity during site construction. Hence, it will be crucial to understand the risk associated with the underground construction operation that can reactivate seismogenic features nearby the future location of emplacement tunnels. Here we present numerical simulation aimed at understanding the potential for inducing seismicity during tunnel construction. The stress changes and their evolution during the excavation are evaluated with a finite element solver (FLAC3d). A strain-softening friction model is then used to simulate the occurrence of a sudden slip on a fault zone (if critical conditions for reactivation are reached). We also present a sensitivity analysis of the potential for inducing different seismic events by different tunnel sizes at varying distance from a nearby failure plane, with the final purpose of evaluating safety of a potential nuclear repository site on the short- and long-term.

  19. Longitudinal soliton tunneling in optical fiber.

    Science.gov (United States)

    Marest, T; Braud, F; Conforti, M; Wabnitz, S; Mussot, A; Kudlinski, A

    2017-06-15

    We report the observation of the longitudinal soliton tunneling effect in axially varying optical fibers. A fundamental soliton, initially propagating in the anomalous dispersion region of a fiber, can pass through a normal dispersion barrier without being substantially affected. We perform experimental studies by means of spectral and temporal characterizations that show the evidence of the longitudinal soliton tunneling process. Our results are well supported by numerical simulations using the generalized nonlinear Schrödinger equation.

  20. Geology of Pletovarje motorway tunnel (Slovenia

    Directory of Open Access Journals (Sweden)

    Magda Čarman

    2009-06-01

    Full Text Available Styrian motorway crosses the Pletovarje ridge through the tunnel having the same name. It intersects the mosteastern extension of the Southern Karavanke tectonic unit. Considering geological conditions, the tunnel couldbe divided into three sections: the inner Donat / Dona~ka fault zone composed of tectonic lenses of differentlithostratigraphic units (of paleozoic, triassic and tertiary age, massive dolomite (lower triassic and Smrekovecseries of oligocene age. Main faults have east – west direction and are subvertical.

  1. [Carpal tunnel syndrome in handicraft planning].

    Science.gov (United States)

    Bancone, C; Leghissa, P; Santini, M; Cologni, G; Bacis, M; Mosconi, G

    2007-01-01

    The purpose of this study is to assess the prevalence of carpal tunnel syndrome (CTS) in a group of bakers and to evaluate the presence of a biomechanical risk for upper limbs in the technological cycle. Health assessment (history, clinical examination, upper limbs electromyography) and risk evaluation through Check List OCRA (Occupational Repetitive Actions - Colombini / Occhipinti) have confirmed the initial hypothesis, placing this profession between those at risk for carpal tunnel syndrome.

  2. Spin Tunneling in a Rotating Nanomagnet

    Science.gov (United States)

    O'Keeffe, Michael; Chudnovsky, Eugene; Lehman College Theoretical Condensed Matter Physics Team

    2011-03-01

    We study spin tunneling in a magnetic nanoparticle with biaxial anisotropy that is free to rotate about its anisotropy axis. Exact instanton of the coupled equations of motion is found that connects degenerate classical energy minima. We show that mechanical freedom of the particle renormalizes magnetic anisotropy and increases the tunnel splitting. M. F. O'Keeffe and E. M. Chudnovsky, cond-mat, arXiv:1011.3134.

  3. Work on a transfer tunnel access shaft

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Civil engineers work on one of the access shafts from the SPS to the LHC transfer tunnel, which will allow components and equipment to be lowered directly so that minimal transport is required. The transfer tunnel will take a proton beam from the SPS pre-accelerator and inject it into the clockwise circulating ring in the LHC where the beam will be accelerated to a final energy of 7 TeV.

  4. Bone tunnel change develops within two weeks of double-bundle anterior cruciate ligament reconstruction using hamstring autograft: A comparison of different postoperative immobilization periods using computed tomography.

    Science.gov (United States)

    Shimizu, Ryo; Adachi, Nobuo; Ishifuro, Minoru; Nakamae, Atsuo; Ishikawa, Masakazu; Deie, Masataka; Ochi, Mitsuo

    2017-10-01

    The purpose of this study was to evaluate bone tunnel changes following anterior cruciate ligament (ACL) reconstruction during the early postoperative period using computed tomography (CT), and to understand the impact of postoperative immobilization on these changes. Twenty patients who underwent double-bundle ACL reconstruction using hamstring tendon autografts were included. We subcategorized patients into two groups: patients who underwent isolated ACL reconstruction and had three days of knee immobilization (Group A, n=10); and patients with concomitant meniscus injuries who underwent ACL reconstruction and meniscus repair simultaneously (Group B, n=10) had their knees immobilized for two weeks after surgery. Bone tunnel enlargement was evaluated using CT imaging at one to three days, two weeks, one month, three months and six months after surgery. The cross-sectional area of the femoral and tibial tunnels was measured, and enlargement rate was calculated. The tunnel center location at two weeks after surgery was also evaluated. The mean cross-sectional area adjacent to the joint space of the femoral and tibial tunnels significantly increased immediately after surgery, especially in the first month (P0.01). There was no significant difference in tunnel enlargement rate between group A and B. Tunnel center location changed even in the first two weeks. Bone tunnel enlargement following double-bundle ACL reconstruction occurred at an earlier time point after surgery than anticipated. Postoperative immobilization could not prevent bone tunnel enlargement, but might prevent tunnel migration. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component.

    Science.gov (United States)

    Ichikawa, Yasushi; Nagashima, Yoji; Morioka, Kaori; Akimoto, Kazunori; Kojima, Yasuyuki; Ishikawa, Takashi; Goto, Ayumu; Kobayashi, Noritoshi; Watanabe, Kazuteru; Ota, Mitsuyoshi; Fujii, Shoichi; Kawamata, Mayumi; Takagawa, Ryo; Kunizaki, Chikara; Takahashi, Hirokazu; Nakajima, Atsushi; Maeda, Shin; Shimada, Hiroshi; Inayama, Yoshiaki; Ohno, Shigeo; Endo, Itaru

    2014-09-01

    Colorectal flat-type tumors include laterally spreading tumors (LSTs) and flat depressed-type tumors. The former of which shows a predominant lateral spreading growth rather than an invasive growth. The present study examined the morphological characteristics of LSTs, in comparison with polypoid- or flat depressed-type tumors, along with the expression of atypical protein kinase C (aPKC) λ/ι, a pivotal cell polarity regulator, and the hallmarks of cell polarity, as well as with type IV collagen, β-catenin and E-cadherin. In total, 37 flat-type (24 LSTs and 13 flat depressed-type tumors) and 20 polypoid-type colorectal tumors were examined. The LSTs were classified as 15 LST adenoma (LST-A) and nine LST cancer in adenoma (LST-CA). An immunohistochemical examination was performed on aPKC λ/ι, type IV collagen, β-catenin and E-cadherin. The LST-A and -CA showed a superficial replacing growth pattern, with expression of β-catenin and E-cadherin in the basolateral membrane and type IV collagen along the basement membrane. In addition, 86.6% of LST-A and 55.6% of LST-CA showed aPKC λ/ι expression of 1+ (weak to normal intensity staining in the cytoplasm compared with the normal epithelium). Furthermore, ~45% of the polypoid-type adenomas showed 2+ (moderate intensity staining in the cytoplasm and/or nucleus) and 66.7% of the polypoid-type cancer in adenoma were 3+ (strong intensity staining in the cytoplasm and nucleus). A statistically significant positive correlation was observed between the expression of aPKC λ/ι and β-catenin (r=0.842; P<0.001), or type IV collagen (r=0.823; P<0.001). The LSTs showed a unique growth pattern, different from the expanding growth pattern presented by a polypoid tumor and invasive cancer. The growth characteristics of LST appear to be caused by adequate coexpression of β-catenin, type IV collagen and aPKC λ/ι.

  6. Investigations on tunneling and kissing bond defects in FSW joints for dissimilar aluminum alloys

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Noor Zaman, E-mail: noor_0315@yahoo.com [Department of Mechanical Engineering, Jamia Millia Islamia (A Central University), New Delhi (India); Siddiquee, Arshad Noor; Khan, Zahid A. [Department of Mechanical Engineering, Jamia Millia Islamia (A Central University), New Delhi (India); Shihab, Suha K. [Department of Mechanical Engineering, Engineering College, Diyala University, Diyala (Iraq)

    2015-11-05

    In this paper an attempt has been made to investigate the effect of two Friction Stir Welding (FSW) parameters i.e. tool pin offset and tool plunge depth on the formation of defects such as tunnel (tunneling defect) and kissing bond (KB) during welding of dissimilar aluminum alloys. 4.75 mm thick plates of AA5083-H116 and AA6063-T6 were welded using a novel work-fixture developed in-house which, apart from clamping the plated also imparted continuous variation of offset on both side of the faying line. The tunneling defect was modeled as a function of offset and plunge depth. The welds were characterised using optical microscopy (OM), scanning electron microscopy (SEM) and mechanical testing. The causes of such defects have been analyzed and discussed and recommendations have been made to prevent their occurrence. The findings of the study have revealed that the tunneling defects are formed at all offset (including zero offset) values towards stronger material (advancing side). And the cross-section of the tunnel varied with the amount of offset. Further, KBs are formed at the interface for all pin offset values except 0.5 mm towards weaker material and high plunge depth resulting in the poor mechanical properties. - Highlights: • Two dissimilar aluminum alloys are welded using FSW. • Formation of kissing bond and tunneling defects are investigated. • Defects are formed at pin offsets towards stronger material and also without offset. • The size of tunnel reduces significantly by increasing the plunge depth. • Tool pin offset towards weaker material prevent tunneling defects.

  7. Endoscopic release for carpal tunnel syndrome.

    Science.gov (United States)

    Vasiliadis, Haris S; Georgoulas, Petros; Shrier, Ian; Salanti, Georgia; Scholten, Rob J P M

    2014-01-31

    Carpal tunnel syndrome (CTS) is the most common compressive neuropathy of the upper extremity. It is caused by increased pressure on the median nerve between the transverse carpal ligament and the carpal bones. Surgical treatment consists of the release of the nerve by cutting the transverse carpal ligament. This can be done either with an open approach or endoscopically. To assess the effectiveness and safety of the endoscopic techniques of carpal tunnel release compared to any other surgical intervention for the treatment of CTS. More specifically, to evaluate the relative impact of endoscopic techniques in relieving symptoms, producing functional recovery (return to work and return to daily activities) and reducing complication rates. This review fully incorporates the results of searches conducted up to 5 November 2012, when we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE and EMBASE. There were no language restrictions. We reviewed the reference lists of relevant articles and contacted trial authors. We also searched trial registers for ongoing trials. We performed a preliminary screen of searches to November 2013 to identify any additional recent publications. We included any randomised controlled trials (RCTs) and quasi-RCTs comparing endoscopic carpal tunnel release (ECTR) with any other surgical intervention for the treatment of CTS. We used standard methodological procedures expected by the Cochrane Collaboration. Twenty-eight studies (2586 hands) were included. Twenty-three studies compared ECTR to standard open carpal tunnel release (OCTR), five studies compared ECTR with OCTR using a modified incision, and two studies used a three-arm design to compare ECTR, standard OCTR and modified OCTR.At short-term follow-up (three months or less), only one study provided data for overall improvement. We found no differences on the Symptom Severity Scale (SSS) (scale zero to five) (five studies, standardised mean

  8. Nonlinear earthquake behaviour of highway tunnels

    Directory of Open Access Journals (Sweden)

    B. Sevim

    2011-10-01

    Full Text Available This paper describes the Arhavi Highway Tunnel which has two tubes, its geometrical properties, finite element model, and the nonlinear earthquake behaviour under a huge ground motion considering soil-structure interaction. The Arhavi Highway Tunnel is one of the tallest tunnels constructed in the Black Sea region of Turkey as part of the Coast Road Project. The tunnel has two tubes and each of them is about 1000 m tall. In the study, the modal analyses of the tunnel considering soil-structure interaction are performed and natural frequencies and mode shapes are obtained. Then, nonlinear transient analysis of the tunnel using Drucker-Prager criteria is performed applying acceleration components of 1992 Erzincan, Turkey earthquake's ground motion. In the time history analyses, Rayleigh damping coefficients are calculated using main natural frequency obtained from modal analysis. Element matrices are computed using the Gauss numerical integration technique. The Newmark method is used in the solution of the equation of motion. Because too much memory for the analyses is required, the first 7.5 s of the ground motions, which is the most effective duration, is taken into account in calculations. The displacement and stress results are observed to be the allowable level of the concrete material.

  9. Quantum tunneling of magnetization in solids

    International Nuclear Information System (INIS)

    Stamp, P.C.E.; Barbara, B.

    1992-01-01

    Magnetic solids should, under certain circumstances, show macroscopic quantum behavior, in which coherence exists between completely distinct magnetization states, each involving a very large number of spins (∼10 12 spins). This article reviews the recent work in this field, concentrating particularly on macroscopic quantum tunneling (MQT) of magnetization. The two main phenomena discussed are the tunneling of magnetization in single-domain particles or grains (in which some 10 3 - 10 4 spins rotate together through an energy barrier), and the tunneling of domain walls in films or in bulk magnets; where walls containing ∼10 10 spins may tunnel off a pinning potential, or from one pinning center to another. Some attention is also given to the quantum nucleation of magnetization reversal in a bulk magnet, and to the quantum motion of other magnetic solitons (such as vortices). After a thorough analysis of the basic grain and wall tunneling phenomena, the authors continue on to a discussion of the various dissipative or decoherence mechanisms, which destroy the phase correlations involved in tunneling. The coupling of grain magnetization to phonons, photons, and electrons is shown to have little consequence for weakly-conducting or insulating grains. Domain walls couple to these and also to magnons and impurities or defects; the 3rd order coupling to magnons can have serious effects, but if one uses pure insulators at low temperatures, these can also be ignored

  10. Optical modulator including grapene

    Science.gov (United States)

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  11. Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Michael Alexander Malahias

    2015-01-01

    Full Text Available Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1-2 mL of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encouraging mid-term outcomes regarding use of platelet-rich plasma for the treatment of carpal tunnel syndrome.

  12. Cryogenic wind tunnel technology. A way to measurement at higher Reynolds numbers

    Science.gov (United States)

    Beck, J. W.

    1984-01-01

    The goals, design, problems, and value of cryogenic transonic wind tunnels being developed in Europe are discussed. The disadvantages inherent in low-Reynolds-number (Re) wind tunnel simulations of aircraft flight at high Re are reviewed, and the cryogenic tunnel is shown to be the most practical method to achieve high Re. The design proposed for the European Transonic Wind tunnel (ETW) is presented: parameters include cross section. DISPLAY 83A46484/2 = 4 sq m, operating pressure = 5 bar, temperature = 110-120 K, maximum Re = 40 x 10 to the 6th, liquid N2 consumption = 40,000 metric tons/year, and power = 39,5 MW. The smaller Cologne subsonic tunnel being adapted to cryogenic use for preliminary studies is described. Problems of configuration, materials, and liquid N2 evaporation and handling and the research underway to solve them are outlined. The benefits to be gained by the construction of these costly installations are seen more in applied aerodynamics than in basic research in fluid physics. The need for parallel development of both high Re tunnels and computers capable of performing high-Re numerical analysis is stressed.

  13. Prediction Study of Tunnel Collapse Risk in Advance based on Efficacy Coefficient Method and Geological Forecast

    Directory of Open Access Journals (Sweden)

    QIU Daohong

    2014-08-01

    Full Text Available Collapse is one of the most common accidents in underground constructions. Risk evaluation is the method of measuring the risk of chamber collapse. To ensure the safety of construction, a risk evaluation model of tunnel collapse based on an efficacy coefficient method and geological prediction was put forward. Based on the comprehensive analysis of collapse factors, five main factors including rock uniaxial compressive strength, surrounding rock integrated coefficient, state of discontinuous structural planes, the angle between tunnel axis and major structural plane and underground water were chosen as the risk evaluation indices of tunnel collapse. The evaluation indices were quantitatively described by using TSP203 system and core-drilling to establish the risk early warning model of tunnel collapse based on the basic principle of the efficacy coefficient method. The model established in this research was applied in the collapse risk recognition of Kiaochow Bay subsea tunnel in Qingdao, China. The results showed that the collapse risk recognition method presents higher prediction accuracy and provided a new idea for the risk prediction of tunnel collapse.

  14. Finite element simulation of shallow-buried and mining tunnelling in adjacent frame structures

    Directory of Open Access Journals (Sweden)

    Chun-lai Chen

    2014-05-01

    Full Text Available By using three dimensional software MIDAS/GTS, the interactions among structures-soil-tunnel system is considered in this paper, and the working condition of shallow-buried underground excavation is simulated in the foundation of frame structures with the short-pile. The loadings and deformations of structures are studied before and after the tunnelling, and the influences of the following factors, including the horizontal position of tunnel and building, the height of building and the soil property, are analyzed. It is indicated that when the horizontal distance L equals zero (the distance between building axis to the tunnel axis, the building settlement increases gradually and shows a normal distribution during and after the tunnelling. Due to the small stiffness of frame structures with short-pile foundations, the building has large nonuniform settlement. When the distance of excavation is no less than 1.8 times of the thickness of overburden soil, the building settlement becomes stable, and the first principal stress P1 and maximum deformation rate E1 generally show a trend of decrease. With the increasing L, P1 and E1 will decrease accordingly, and the buildings tend to be inclined toward the tunnel. For a relatively larger distance, the building is nearly not affected.

  15. [Anatomical study on the femoral tunnel anatomy reconstruction of anterior cruciate ligament].

    Science.gov (United States)

    Dong, Yi-Long; Cai, Chun-Yuan; Jiang, Wen-Hui; Jiang, Gang-Yi; Qian, Yue-Nan; Zhao, Zhang-Wei; Yang, Guo-Jing

    2013-09-01

    To measure anatomical data of the femoral tunnel anatomy reconstruction of anterior cruciate ligament (ACL), so provide anatomical basis for clinical anatomy reconstruction of ACL. There were 30 adults' cadaveric knee specimens. The ACL femoral tunnel was reconstructed through anterior medial approach (AMP) in genuflex position of 120 degree, and was marked by Kirschner. The soft tissue of the specimen was removed and the femoral condyle was split at the middle side. The index including length of the femoral tunnel, the distance from internal opening of tunnel to cortical edge of femoral condyle and vertical distance to the top of femoral intercondylar notch were measured. Then the time position of internal opening of tunnel in the intercondylar notch was recorded, and the location of outside opening of tunnel to the femoral condyle was detected. The mean length of the femoral tunnel was (36.35 +/- 3.14) mm (ranged, 30.65 to 42.35 mm). The distance from internal opening of tunnel to cortical edge of femoral condyle was (17.84 +/- 3.35) mm (ranged, 14.02 to 23.49 mm), vertical distance to the top of femoral intercondylar notch was (14.05 +/- 2.32) mm (ranged, 9.17 to 20.08 mm). According to the way of circular dial,internal opening of tunnel located at 02:30 +/- 00:10 (ranged, 01:50 to 02:50) in the left knee,and 09:30 +/- 0:15 (ranged, 08:30 to 10:40) in the right knee. The outside opening of femoral tunnel located at (3.16 +/- 2.51) mm (ranged, 1.61 to 6.30 mm) to the proximal end of external epicondyle of femur, and (4.25 +/- 2.16) mm (ranged, 1.73 to 8.52 mm) to the posterior of external epicondyle of femur. The anatomical features of femoral tunnel for reconstruction of ACL is revealed,which will provide anatomical basis for clinical practice.

  16. Application of Recognition Tunneling in Single Molecule Identification

    Science.gov (United States)

    Zhao, Yanan

    Single molecule identification is one essential application area of nanotechnology. The application areas including DNA sequencing, peptide sequencing, early disease detection and other industrial applications such as quantitative and quantitative analysis of impurities, etc. The recognition tunneling technique we have developed shows that after functionalization of the probe and substrate of a conventional Scanning Tunneling Microscope with recognition molecules ("tethered molecule-pair" configuration), analyte molecules trapped in the gap that is formed by probe and substrate will bond with the reagent molecules. The stochastic bond formation/breakage fluctuations give insight into the nature of the intermolecular bonding at a single molecule-pair level. The distinct time domain and frequency domain features of tunneling signals were extracted from raw signals of analytes such as amino acids and their enantiomers. The Support Vector Machine (a machine-learning method) was used to do classification and predication based on the signal features generated by analytes, giving over 90% accuracy of separation of up to seven analytes. This opens up a new interface between chemistry and electronics with immediate implications for rapid Peptide/DNA sequencing and molecule identification at single molecule level.

  17. Bone tunnel enlargement on anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Leonardi, Adriano Barros de Aguiar; Duarte Junior, Aires; Severino, Nilson Roberto

    2014-01-01

    To assess the presence of tibial bone tunnel enlargement after surgical reconstruction of the anterior cruciate ligament using quadruple graft of the flexor tendons and correlate the functional results in their presence. The studied lasted six months and included 25 patients, with ages ranging from 18 to 43 years old. Assessment was based on radiographs taken immediately postoperatively and at the third and sixth month of follow up in the anterior cruciate ligament reconstruction. Reconstruction of ligaments was performed with tendon grafts of the semitendinosus and gracilis muscle fixated in the femur with transverse metal screw and in the tibia with interference screws. Patients were evaluated objectively by tests ligament, graded from zero to four crosses and subjectively by the Lysholm method preoperative and after sixth month follow up. Significant increase in the tunnels diameters were observed, 20.56% for radiographs in the anteroposterior view, 26.48% in profile view and 23.22% in computed tomography. Descriptive statistics showed significant improvement in subjective and objective clinical parameters. The bone tunnel enlargement is a phenomenon found in the first months after surgical reconstruction of the anterior cruciate ligament and it has no implications on clinical outcomes in the short term. Level of Evidence II, Prospective Study.

  18. Radiologic Placement of Tunneled Central Venous Catheters in Pediatric Patients

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eun Ji; Song, Soon Young; Cho, On Koo; Koh, Byung Hee; Kim, Yong Soo; Jeong, Woo Kyoung; Lee, Yong Ho [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    2010-08-15

    We evaluated the technical success and complication rates associated with the radiological placement of tunneled central venous catheters in pediatric patients. Between May 1, 2005 and March 31, 2008, a total of 46 tunneled central venous catheters were placed in 34 children (M:F = 22:12; mean age, 9.9 years [9 months to 16.8 years]). All procedures were performed under ultrasonographic and fluoroscopic guidance. Follow-up data were obtained through the retrospective review of the medical records. We used the Kaplan-Meier survival method for the evaluation of survival rate of the catheters. All procedures were technically successful. The observed periprocedural complications included hematoma formation in three patients. The mean catheter life was 189.3 days (total, 8710 days; range, 7-810). Catheters were removed due to death (n=9), the end of treatment (n=8), catheter sepsis (n=4), malfunction (n=8), and accidental removal (n=4). The rate of catheter sepsis and malfunction was 0.459 and 0.919 for every 1000 catheter days, respectively. The expected mean catheter life was 479.6 days as per the Kaplan- Meier analysis. The results suggest that the radiologic placement of a tunneled central venous catheter is an effective technique with a high technical success rate and low complication rate.

  19. Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies.

    Science.gov (United States)

    Diogo, R; Tanaka, E M

    2012-12-01

    The axolotl Ambystoma mexicanum is one of the most used model organisms in evolutionary, developmental and regenerative studies, particularly because it can reconstitute a fully functional and complete forelimb/hindlimb. Surprisingly, there is no publication that describes all the pectoral and forelimb muscles of this species or provides a comparative framework between these muscles and those of other model organisms and of modern humans. In the present paper we describe and illustrate all these muscles in A. mexicanum and provide the first report about the myology of adults of a model organism that is based on analyses and dissections of both wildtype animals and transgenic animals that express green fluorescent protein (GFP) in muscle fibers. On the one hand, the inclusion of GFP-transgenic animals allows us to show the muscles as more commonly seen, and thus easier to understand, by current developmental and regenerative biologists. On the other hand, by including wildtype and GFP-transgenic animals and by visualizing these latter animals with and without a simultaneous transmission laser light, we were able to obtain a more complete and clearer understanding of the exact limit of the fleshy and tendinous parts of the muscles and their specific connections with the skeletal elements. This in turn allowed us to settle some controversies in previous anatomical and comparative studies. As most developmental, regenerative and evolutionary biologists are interested in comparing their observations of A. mexicanum with observations in other model organisms, and ultimately in using this information to increase the understanding of human evolution and medicine, we also provide tables showing the homologies between the pectoral and forelimb muscles of axolotls, of model organisms such as mice, frogs and chicken, and of Homo sapiens. An example illustrating the outcomes of using our methodology and of our observations is that they revealed that, contrary to what is often

  20. Calculations of air cooler for new subsonic wind tunnel

    Science.gov (United States)

    Rtishcheva, A. S.

    2017-10-01

    As part of the component development of TsAGI’s new subsonic wind tunnel where the air flow velocity in the closed test section is up to 160 m/sec hydraulic and thermal characteristics of air cooler are calculated. The air cooler is one of the most important components due to its highest hydraulic resistance in the whole wind tunnel design. It is important to minimize its hydraulic resistance to ensure the energy efficiency of wind tunnel fans and the cost-cutting of tests. On the other hand the air cooler is to assure the efficient cooling of air flow in such a manner as to maintain the temperature below 40 °C for seamless operation of measuring equipment. Therefore the relevance of this project is driven by the need to develop the air cooler that would demonstrate low hydraulic resistance of air and high thermal effectiveness of heat exchanging surfaces; insofar as the cooling section must be given up per unit time with the amount of heat Q=30 MW according to preliminary evaluations. On basis of calculation research some variants of air cooler designs are proposed including elliptical tubes, round tubes, and lateral plate-like fins. These designs differ by the number of tubes and plates, geometrical characteristics and the material of finned surfaces (aluminium or cooper). Due to the choice of component configurations a high thermal effectiveness is achieved for finned surfaces. The obtained results form the basis of R&D support in designing the new subsonic wind tunnel.

  1. Resonant tunneling in small current-biased Josephson Junctions

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, John Mark [Univ. of California, Berkeley, CA (United States)

    1994-05-01

    Effects of resonant tunneling between bound quantum states of a current-biased Josephson tunnel junction is studied both theoretically and experimentally. Several effects are predicted to arise from resonant tunneling, including a series of voltage peaks along the supercurrent branch of the current-voltage characteristic, and enhanced rate of escape from zero voltage state to voltage state at particular values of bias current. A model is developed to estimate magnitude and duration of voltage peaks, and to estimate enhancement of the escape rate, which appears as peaks in the rate as a function of bias current. An experimental investigation was carried out in an attempt to observe these predicted peaks in the escape rate distribution in a current-biased DC SQUID, which is shown to be dynamically equivalent to a Josephson junction with adjustable critical current. Electrical contact to each SQUID (fabricated from aluminium) was made through high resistance thin film leads located on the substrate. These resistors provided a high impedance at the plasma frequency which is for the isolation of the SQUID from its electromagnetic environment. Measurements were carried out on a dilution refrigerator at temperatures as low as 19 mK. No evidence was found for resonant tunneling; this is attributed to effective temperatures of hundreds of millikelvin. The behavior is well explained by a heating model where the high effective temperatures are generated by ohmic heating of the electron gas of the isolation resistors, which decouples from the phonon system (hot electron effect). The prospects for further theoretical and experimental research are discussed.

  2. Tunnel boring waste test plan

    International Nuclear Information System (INIS)

    Patricio, J.G.

    1984-03-01

    The test plan has been prepared in anticipation of the need to excavate certain repository openings by relying upon mechanical excavation techniques. The test plan proposes that specific technical issues can be resolved and key design parameters defined by excavating openings in basalt near the surface, utilizing a full face tunnel boring machine (TBM). The purpose and objective of this type of testing will define the overall feasibility and attributes of mechanical excavation in basalt. The test plan recognizes that although this technology is generally available for underground construction for some geologic settings, the current state of technology for excavation in basalt is limited and the potential for improvement is considerable. The test plan recommends that it is economically advantageous to conduct additional testing in the laboratory to allow refinement of this plan based on the laboratory results. Thus, this test plan is considered preliminary in nature, with respect to detailed testing recommendations. However, the gross design attributes and resource requirements of a near-surface TBM demonstration are considered to be valid. 15 refs., 7 figs., 3 tabs

  3. Coherence in Magnetic Quantum Tunneling

    Science.gov (United States)

    Fernandez, Julio F.

    2001-03-01

    Crystals of single molecule magnets such as Mn_12 and Fe8 behave at low temperatures as a collection of independent spins. Magnetic anisotropy barriers slow down spin-flip processes. Their rate Γ becomes temperature independent at sufficiently low temperature. Quantum tunneling (QT) accounts for this behavior. Currently, spin QT in Mn_12 and Fe8 is assumed to proceed as an incoherent sum of small probability increments that occur whenever a bias field h(t) (arising from hyperfine interactions with nuclear spins) that varies with time t becomes sufficiently small, as in Landau-Zener transitions. Within a two-state model, we study the behavior of a suitably defined coherence time τ_φ and compare it with the correlation time τh for h(t). It turns out that τ_φ >τ_h, when τ_hδ h < hbar, where δ h is the rms deviation of h. We show what effect such coherence has on Γ. Its dependence on a static longitudinal applied field Hz is drastically affected. There is however no effect if the field is swept through resonance.

  4. Le LHC, un tunnel cosmique

    CERN Document Server

    CERN. Geneva

    2009-01-01

    Et si la lumière au bout du tunnel du LHC était cosmique ? En d’autres termes, qu’est-ce que le LHC peut nous apporter dans la connaissance de l’Univers ? Car la montée en énergie des accélérateurs de particules nous permet de mieux appréhender l’univers primordial, chaud et dense. Mais dans quel sens dit-on que le LHC reproduit des conditions proches du Big bang ? Quelles informations nous apporte-t-il sur le contenu de l’Univers ? La matière noire est-elle détectable au LHC ? L’énergie noire ? Pourquoi l’antimatière accumulée au CERN est-elle si rare dans l’Univers ? Et si le CERN a bâti sa réputation sur l’exploration des forces faibles et fortes qui opèrent au sein des atomes et de leurs noyaux, est-ce que le LHC peut nous apporter des informations sur la force gravitationnelle qui gouverne l’évolution cosmique ? Depuis une trentaine d’années, notre compréhension de l’univers dans ses plus grandes dimensions et l’appréhension de son comportement aux plus peti...

  5. The Diversity of Yellow-Related Proteins in Sand Flies (Diptera: Psychodidae).

    Science.gov (United States)

    Sima, Michal; Novotny, Marian; Pravda, Lukas; Sumova, Petra; Rohousova, Iva; Volf, Petr

    2016-01-01

    Yellow-related proteins (YRPs) present in sand fly saliva act as affinity binders of bioamines, and help the fly to complete a bloodmeal by scavenging the physiological signals of damaged cells. They are also the main antigens in sand fly saliva and their recombinant form is used as a marker of host exposure to sand flies. Moreover, several salivary proteins and plasmids coding these proteins induce strong immune response in hosts bitten by sand flies and are being used to design protecting vaccines against Leishmania parasites. In this study, thirty two 3D models of different yellow-related proteins from thirteen sand fly species of two genera were constructed based on the known protein structure from Lutzomyia longipalpis. We also studied evolutionary relationships among species based on protein sequences as well as sequence and structural variability of their ligand-binding site. All of these 33 sand fly YRPs shared a similar structure, including a unique tunnel that connects the ligand-binding site with the solvent by two independent paths. However, intraspecific modifications found among these proteins affects the charges of the entrances to the tunnel, the length of the tunnel and its hydrophobicity. We suggest that these structural and sequential differences influence the ligand-binding abilities of these proteins and provide sand flies with a greater number of YRP paralogs with more nuanced answers to bioamines. All these characteristics allow us to better evaluate these proteins with respect to their potential use as part of anti-Leishmania vaccines or as an antigen to measure host exposure to sand flies.

  6. The Diversity of Yellow-Related Proteins in Sand Flies (Diptera: Psychodidae.

    Directory of Open Access Journals (Sweden)

    Michal Sima

    Full Text Available Yellow-related proteins (YRPs present in sand fly saliva act as affinity binders of bioamines, and help the fly to complete a bloodmeal by scavenging the physiological signals of damaged cells. They are also the main antigens in sand fly saliva and their recombinant form is used as a marker of host exposure to sand flies. Moreover, several salivary proteins and plasmids coding these proteins induce strong immune response in hosts bitten by sand flies and are being used to design protecting vaccines against Leishmania parasites. In this study, thirty two 3D models of different yellow-related proteins from thirteen sand fly species of two genera were constructed based on the known protein structure from Lutzomyia longipalpis. We also studied evolutionary relationships among species based on protein sequences as well as sequence and structural variability of their ligand-binding site. All of these 33 sand fly YRPs shared a similar structure, including a unique tunnel that connects the ligand-binding site with the solvent by two independent paths. However, intraspecific modifications found among these proteins affects the charges of the entrances to the tunnel, the length of the tunnel and its hydrophobicity. We suggest that these structural and sequential differences influence the ligand-binding abilities of these proteins and provide sand flies with a greater number of YRP paralogs with more nuanced answers to bioamines. All these characteristics allow us to better evaluate these proteins with respect to their potential use as part of anti-Leishmania vaccines or as an antigen to measure host exposure to sand flies.

  7. Correlation of tunnel widening and tunnel positioning with short-term functional outcomes in single-bundle anterior cruciate ligament reconstruction using patellar tendon versus hamstring graft: a prospective study.

    Science.gov (United States)

    Biswal, Udit Kumar; Balaji, Gopisankar; Nema, Sandeep; Poduval, Murali; Menon, Jagdish; Patro, Dilip Kumar

    2016-08-01

    To study the correlation between tunnel widening and tunnel position with short-term functional outcomes post-ACL reconstruction with patellar tendon and hamstring autografts in young adults. A total of 33 patients who underwent ACL reconstruction between October 2013 and February 2015 were included and followed up for 6 months. A standardized surgical technique was used for each graft type. Intra-op arthroscopy findings and drilled tunnel diameters were noted. They were followed up for 3 and 6 months. Radiological assessment was done at 3 and 6 months with clinical score assessment at 6 months. At 6 months, clinical scores were comparable in both groups. Tunnel widening in both femoral and tibial tunnel at 3 and 6 months were significantly higher in STG group (p values <0.05). The rate of widening was higher in 0-3 months and reduced in 3-6 months. There was statistically significant negative correlation between femoral tunnel widening by CT and IKDC score at 6 months (p value 0.049). We found a positive correlation between posterior positioning of femoral tunnel and Lysholm and IKDC scores. The correlation with Lysholm scores was statistically significant (p value 0.046). To conclude, tunnel widening is more with hamstrings graft. Femoral tunnel widening has significant negative correlation with that of IKDC scores at 6 months. Posterior femoral tunnel positioning and Lysholm scores at 6 months had significant correlation.

  8. Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: A randomized, double-blind clinical trial

    Science.gov (United States)

    The utility of dairy ingredients in the supplementary foods used in the treatment of childhood moderate acute malnutrition (MAM) remains unsettled. We evaluated the effectiveness of a peanut-based ready-to-use supplementary food (RUSF) with soy protein compared with a novel RUSF containing dairy in...

  9. Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial.

    Science.gov (United States)

    Stobaugh, Heather C; Ryan, Kelsey N; Kennedy, Julie A; Grise, Jennifer B; Crocker, Audrey H; Thakwalakwa, Chrissie; Litkowski, Patricia E; Maleta, Kenneth M; Manary, Mark J; Trehan, Indi

    2016-03-01

    The utility of dairy ingredients in the supplementary foods used in the treatment of childhood moderate acute malnutrition (MAM) remains unsettled. We evaluated the effectiveness of a peanut-based ready-to-use supplementary food (RUSF) with soy protein compared with a novel RUSF containing dairy ingredients in the form of whey permeate and whey protein concentrate in the treatment of children with MAM. We conducted a randomized, double-blind clinical effectiveness trial involving rural Malawian and Mozambican children 6-59 mo of age with MAM treated with either soy RUSF or a novel whey RUSF treatment of ~75 kcal · kg(-1) · d(-1) for up to 12 wk. The proportion of children that recovered from MAM was significantly higher in the group that received whey RUSF (960 of 1144; 83.9%) than in the group that received soy RUSF (874 of 1086; 80.5%; P whey RUSF also demonstrated better growth markers, with a higher mean midupper arm circumference (MUAC) at the time of discharge (P protein in the treatment of MAM, because the use of a novel whey RUSF resulted in higher recovery rates and improved growth than did soy RUSF, although the whey RUSF supplement provided less total protein and energy than the soy RUSF. This study was registered at clinicaltrials.gov as NCT01790048. © 2016 American Society for Nutrition.

  10. Full-Scale Wind Tunnel Test of an Individual Blade Control System for a UH-60 Helicopter

    National Research Council Canada - National Science Library

    Jacklin, Stephen A; Haber, Axel; de Simone, Gary; Norman, Thomas R; Kitaplioglu, Cahit; Shinoda, Patrick

    2002-01-01

    .... The acquired wind tunnel data set includes measurements of rotor performance, steady and dynamic hub forces and moments, rotor loads, control system loads, and blade vortex interaction (BVI) noise...

  11. Space shuttle phase B wind tunnel model and test information. Volume 2: Orbiter configuration

    Science.gov (United States)

    Glynn, J. L.; Poucher, D. E.

    1988-01-01

    Archived wind tunnel test data are available for flyback booster or other alternate recoverable configurations as well as reusable orbiters studied during initial development (Phase B) of the Space Shuttle. Considerable wind tunnel data was acquired by the competing contractors and the NASA centers for an extensive variety of configurations with an array of wing and body planforms. All contractor and NASA wind tunnel test data acquiredin the Phase B development have been compiled into a database and are available for applying to current winged flyback or recoverable booster aerodynamic studies. The Space Shuttle Phase B Wind Tunnel Database is structured by vehicle component and configuration type. Basic components include the booster, the orbiter, and the launch vehicle. Booster configuration types include straight and delta wings, canard, cylindrical, retroglide, and twin body. Orbiter configuration types include straight and delta wings, lifting body, drop tanks, and double delta wings. Launch configration types include booster and orbiter components in various stacked and tandom combinations. The digital database consists of 220 files of data containing basic tunnel recorded data.

  12. Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

    Science.gov (United States)

    Wittig, Dierk; Wang, Xiang; Walter, Cindy; Gerdes, Hans-Hermann; Funk, Richard H. W.; Roehlecke, Cora

    2012-01-01

    Background Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of TNTs was examined by immunostaining and scanning electron microscopy. To determine the function of TNTs between cells, we studied the TNT-dependent intercellular communication at different levels including electrical and calcium signalling, small molecular diffusion as well as mitochondrial re-localization. Further, intercellular organelles transfer was assayed by FACS analysis. Methodology and Principal Findings Microscopy showed that cultured ARPE-19 cells are frequently connected by TNTs, which are not attached to the substratum. The TNTs were straight connections between cells, had a typical diameter of 50 to 300 nm and a length of up to 120 µm. We observed de novo formation of TNTs by diverging from migrating cells after a short time of interaction. Scanning electron microscopy confirmed characteristic features of TNTs. Fluorescence microscopy revealed that TNTs between ARPE-19 cells contain F-actin but no microtubules. Depolymerisation of F-actin, induced by addition of latrunculin-B, led to disappearance of TNTs. Importantly, these TNTs could function as channels for the diffusion of small molecules such as Lucifer Yellow, but not for large molecules like Dextran Red. Further, organelle exchange between cells via TNTs was observed by microscopy. Using Ca2+ imaging we show the intercellular transmission of calcium signals through TNTs. Mechanical stimulation led to membrane depolarisation, which expand through TNT connections between ARPE-19 cells. We further demonstrate that TNTs can mediate electrical coupling between distant cells. Immunolabelling for Cx43 showed that this gap junction protein is interposed at one end of 44% of TNTs between ARPE-19 cells. Conclusions and Significance Our observations indicate that human RPE cell line ARPE

  13. Rotary Balance Wind Tunnel Testing for the FASER Flight Research Aircraft

    Science.gov (United States)

    Denham, Casey; Owens, D. Bruce

    2016-01-01

    Flight dynamics research was conducted to collect and analyze rotary balance wind tunnel test data in order to improve the aerodynamic simulation and modeling of a low-cost small unmanned aircraft called FASER (Free-flying Aircraft for Sub-scale Experimental Research). The impetus for using FASER was to provide risk and cost reduction for flight testing of more expensive aircraft and assist in the improvement of wind tunnel and flight test techniques, and control laws. The FASER research aircraft has the benefit of allowing wind tunnel and flight tests to be conducted on the same model, improving correlation between wind tunnel, flight, and simulation data. Prior wind tunnel tests include a static force and moment test, including power effects, and a roll and yaw damping forced oscillation test. Rotary balance testing allows for the calculation of aircraft rotary derivatives and the prediction of steady-state spins. The rotary balance wind tunnel test was conducted in the NASA Langley Research Center (LaRC) 20-Foot Vertical Spin Tunnel (VST). Rotary balance testing includes runs for a set of given angular rotation rates at a range of angles of attack and sideslip angles in order to fully characterize the aircraft rotary dynamics. Tests were performed at angles of attack from 0 to 50 degrees, sideslip angles of -5 to 10 degrees, and non-dimensional spin rates from -0.5 to 0.5. The effects of pro-spin elevator and rudder deflection and pro- and anti-spin elevator, rudder, and aileron deflection were examined. The data are presented to illustrate the functional dependence of the forces and moments on angle of attack, sideslip angle, and angular rate for the rotary contributions to the forces and moments. Further investigation is necessary to fully characterize the control effectors. The data were also used with a steady state spin prediction tool that did not predict an equilibrium spin mode.

  14. Recombinant protein production technology

    Science.gov (United States)

    Recombinant protein production is an important technology for antibody production, biochemical activity study, and structural determination during the post-genomic era. Limiting factors in recombinant protein production include low-level protein expression, protein precipitation, and loss of protein...

  15. Tunneling Nanotubes: Intimate Communication between Myeloid Cells

    Directory of Open Access Journals (Sweden)

    Maeva Dupont

    2018-01-01

    Full Text Available Tunneling nanotubes (TNT are dynamic connections between cells, which represent a novel route for cell-to-cell communication. A growing body of evidence points TNT towards a role for intercellular exchanges of signals, molecules, organelles, and pathogens, involving them in a diverse array of functions. TNT form among several cell types, including neuronal cells, epithelial cells, and almost all immune cells. In myeloid cells (e.g., macrophages, dendritic cells, and osteoclasts, intercellular communication via TNT contributes to their differentiation and immune functions. Importantly, TNT enable myeloid cells to communicate with a targeted neighboring or distant cell, as well as with other cell types, therefore creating a complex variety of cellular exchanges. TNT also contribute to pathogen spread as they serve as “corridors” from a cell to another. Herein, we addressed the complexity of the definition and in vitro characterization of TNT in innate immune cells, the different processes involved in their formation, and their relevance in vivo. We also assess our current understanding of how TNT participate in immune surveillance and the spread of pathogens, with a particular interest for HIV-1. Overall, despite recent progress in this growing research field, we highlight that further investigation is needed to better unveil the role of TNT in both physiological and pathological conditions.

  16. Fabrication of magnetic tunnel junctions with a single-crystalline LiF tunnel barrier

    Science.gov (United States)

    Krishna Narayananellore, Sai; Doko, Naoki; Matsuo, Norihiro; Saito, Hidekazu; Yuasa, Shinji

    2018-04-01

    We fabricated Fe/LiF/Fe magnetic tunnel junctions (MTJs) by molecular beam epitaxy on a MgO(001) substrate, where LiF is an insulating tunnel barrier with the same crystal structure as MgO (rock-salt type). Crystallographical studies such as transmission electron microscopy and nanobeam electron diffraction observations revealed that the LiF tunnel barrier is single-crystalline and has a LiF(001)[100] ∥ bottom Fe(001)[110] crystal orientation, which is constructed in the same manner as MgO(001) on Fe(001). Also, the in-plane lattice mismatch between the LiF tunnel barrier and the Fe bottom electrode was estimated to be small (about 0.5%). Despite such advantages for the tunnel barrier of the MTJ, the observed tunnel magnetoresistance (MR) ratio was low (˜6% at 20 K) and showed a significant decrease with increasing temperature (˜1% at room temperature). The results imply that indirect tunneling and/or thermally excited carriers in the LiF tunnel barrier, in which the current basically is not spin-polarized, play a major role in electrical transport in the MTJ.

  17. The significance of ultrasonographic carpal tunnel outlet measurements in the diagnosis of carpal tunnel syndrome.

    Science.gov (United States)

    Csillik, Anita; Bereczki, Dániel; Bora, László; Arányi, Zsuzsanna

    2016-12-01

    A retrospective study to investigate the utility of ultrasonographic carpal tunnel outlet measurements in the diagnosis of carpal tunnel syndrome (CTS). 118 hands of 87 patients with electrophysiologically confirmed CTS and 44 control hands of 23 subjects were assessed. Cross-sectional areas (CSA) of the median nerve were measured at the tunnel inlet, outlet, and forearm. Longitudinal diameters (LAPD) were measured at the inlet, proximal tunnel, distal tunnel, and outlet. CSA at the outlet (median: 18mm 2 ) and its palm-to-forearm-ratio (median: 2.7) were significantly larger than CSA at the inlet (median: 15mm 2 ) and its wrist-to-forearm-ratio (median: 2.2) (poutlet versus 13% only at the inlet. LAPD jump was significantly greater, suggesting relief of higher pressure, at the outlet/distal tunnel versus inlet/proximal tunnel (poutlet than at the inlet. We postulate that this is explained by the progressive increase of pressure within the tunnel from proximal to distal. The addition of CSA outlet measurements to inlet measurements increased CTS ultrasonographic diagnostic sensitivity and accuracy by 15% and 10%, respectively. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  18. The effect of intraoperative fluoroscopy on the accuracy of femoral tunnel placement in single-bundle anatomic ACL reconstruction.

    Science.gov (United States)

    Inderhaug, Eivind; Larsen, Allan; Waaler, Per Arne; Strand, Torbjørn; Harlem, Thomas; Solheim, Eirik

    2017-04-01

    The purpose of the current study was to investigate the potential effect of intraoperative fluoroscopy on the accuracy of femoral tunnel placement in anatomic ACL reconstruction, using an ideal anatomic point as reference and evaluating postoperative tunnel placement based on 3D CT. An experienced ACL surgeon, using the anatomic approach for femoral tunnel placement, relying on intraarticular landmarks and remnants of the torn ACL-and novel to the fluoroscopic assist-was introduced to its use. A prospective series of patients was included where group 1 (without fluoroscopy) and group 2 (with fluoroscopy) both had postoperative CT scans so that femoral tunnel position could be evaluated and compared to an ideal tunnel centre based on anatomic studies by using the Bernard and Hertel grid. Group 2, where fluoroscopy was used, had a mean femoral tunnel that was closer to the ideal anatomic centre than group 1. In the Bernard and Hertel grid, the distance in the high-low axis (y-axis) was found significantly closer (P = 0.001), whilst the deep-shallow axis (x-axis) and a total absolute distance were not significantly closer to the ideal described anatomic centre. Intraoperative fluoroscopy was found effective as an aid for placing the femoral tunnel in a more accurate position, as compared to a desired anatomic centre. Although the concept of the "one-size-fits-all" approach for tunnel placement is debatable, the avoidance of grossly misplaced tunnels is the benefit of using fluoroscopy during ACL reconstruction. The authors hold that fluoroscopy is readily available, safe and easy to use and therefore a good aid in the anatomic approach for graft tunnel placement, for example, in a learning situation, in revision cases and when performing low volumes of such surgery. III.

  19. Comparison of femoral tunnel widening between outside-in and trans-tibial double-bundle ACL reconstruction.

    Science.gov (United States)

    Lee, Yong Seuk; Lee, Beom Koo; Oh, Won Seok; Cho, Yong Kyun

    2014-09-01

    The objectives of this study were to compare (1) the degree of widening by comparing the diameter at the most widened area and the site of widening by measuring the distance from the tunnel entrance to the most widened area in two femoral tunnels (anteromedial and posterolateral), and (2) the morphologic change at the tunnel entrance between outside-in and trans-tibial double-bundle anterior cruciate ligament (ACL) reconstruction. A retrospective study that included 17 trans-tibial and 19 outside-in double-bundle ACL reconstructed patients was conducted for evaluation of serial computed tomography (CT) scan (immediate post-operation and post-operative 1 year). Digital image communication in medicine (DICOM) data was extracted from the PiViewSTAR and imported into OsiriX, which was installed on a Macbook Pro laptop computer. Diameter of the most widened area and distance from the entrance to this point were measured from each of two perpendicular (sagittal and coronal) planes that were accurately realigned parallel to the tunnel direction. Change in the morphology of the tunnel entrance between immediate post-operation and 1-year post-operation was evaluated. Widening was observed in both planes of both tunnels in the two techniques. However, no statistical significances in the diameter of most widened area and distance from the tunnel entrance to the most widened point were observed between the both techniques (n.s.). Distances from the centre point to each four sections showed an increase in all four sections of all both tunnels in both techniques. However, no statistical significance was observed between the two techniques (n.s.). Widening was observed in all tunnels using both techniques and degrees, and sites of the widening did not differ between groups. Morphologic change at the tunnel entrance was not limited to the specific direction and occurred in all directions without significant difference between groups. Retrospective comparative study, Level III.

  20. Airborne asbestos fibres monitoring in tunnel excavation.

    Science.gov (United States)

    Gaggero, Laura; Sanguineti, Elisa; Yus González, Adrián; Militello, Gaia Maria; Scuderi, Alberto; Parisi, Giovanni

    2017-07-01

    Tunnelling across ophiolitic formation with Naturally Occurring Asbestos (NOA) can release fibres into the environment, exposing workers, and the population, if fibres spread outside the tunnel, leading to increased risk of developing asbestos-related disease. Therefore, a careful plan of environmental monitoring is carried out during Terzo Valico tunnel excavation. In the present study, data of 1571 samples of airborne dust, collected between 2014 and 2016 inside the tunnels, and analyzed by SEM-EDS for quantification of workers exposure, are discussed. In particular, the engineering and monitoring management of 100 m tunnelling excavation across a serpentinite lens (Cravasco adit), intercalated within calcschists, is reported. At this chrysotile occurrence, 84% of 128 analyzed samples (from the zone closer to the front rock) were above 2 ff/l. However, thanks to safety measures implemented and tunnel compartmentation in zones, the asbestos fibre concentration did not exceed the Italian standard of occupational exposure (100 ff/l) and 100% of samples collected in the outdoor square were below 1 ff/l. During excavation under normal working conditions, asbestos concentrations were below 2 ff/l in 97.4% of the 668 analyzed samples. Our results showed that air monitoring can objectively confirm the presence of asbestos minerals at a rock front in relative short time and provide information about the nature of the lithology at the front. The present dataset, the engineering measures described and the operative conclusions are liable to support the improvement of legislation on workers exposure to asbestos referred to the tunnelling sector, lacking at present. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Design of Intelligent Power Supply System for Expressway Tunnel

    Science.gov (United States)

    Wang, Li; Li, Yutong; Lin, Zimian

    2018-01-01

    Tunnel lighting program is one of the key points of tunnel infrastructure construction. As tunnels tend to handle remote locations, power supply line construction generally has been having the distance, investment, high cost characteristics. To solve this problem, we propose a green, environmentally friendly, energy-efficient lighting system. This program uses the piston-wind which cars within tunnel produce as the power and combines with solar energy, physical lighting to achieve it, which solves the problem of difficult and high cost of highway tunnel section, and provides new ideas for the future construction of tunnel power supply.

  2. Current evidence for effectiveness of interventions for cubital tunnel syndrome, radial tunnel syndrome, instability, or bursitis of the elbow: a systematic review.

    Science.gov (United States)

    Rinkel, Willem D; Schreuders, Ton A R; Koes, Bart W; Huisstede, Bionka M A

    2013-12-01

    To provide an evidence-based overview of the effectiveness of interventions for 4 nontraumatic painful disorders sharing the anatomic region of the elbow: cubital tunnel syndrome, radial tunnel syndrome, elbow instability, and olecranon bursitis. The Cochrane Library, PubMed, Embase, PEDro, and CINAHL were searched to identify relevant reviews and randomized clinical trials (RCTs). Two reviewers independently extracted data and assessed the quality of the methodology. A best-evidence synthesis was used to summarize the results. One systematic review and 6 RCTs were included. For the surgical treatment of cubital tunnel syndrome (1 review, 3 RCTs), comparing simple decompression with anterior ulnar nerve transposition, no evidence was found in favor of either one of these. Limited evidence was found in favor of medial epicondylectomy versus anterior transposition and for early postoperative therapy versus immobilization. No evidence was found for the effect of local steroid injection in addition to splinting. No RCTs were found for radial tunnel syndrome. For olecranon bursitis (1 RCT), limited evidence for effectiveness was found for methylprednisolone acetate injection plus naproxen. Concerning elbow instability, including 2 RCTs, one showed that nonsurgical treatment resulted in similar results compared with surgery, whereas the other found limited evidence for the effectiveness in favor of early mobilization versus 3 weeks of immobilization after surgery. In this review no, or at best, limited evidence was found for the effectiveness of nonsurgical and surgical interventions to treat painful cubital tunnel syndrome, radial tunnel syndrome, elbow instability, or olecranon bursitis. Well-designed and well-conducted RCTs are clearly needed in this field.

  3. Complex use of heat-exchange tunnels

    Directory of Open Access Journals (Sweden)

    А. Ф. Галкин

    2017-04-01

    Full Text Available The paper presents separate results of complex research (experimental and theoretical on the application of heat-exchange tunnels – in frozen rocks, among other things – as underground constructions serving two purposes. It is proposed to use heat-exchange tunnels as a separate multi-functional module, which under normal conditions will be used to set standards of heat regime parameters in the mines, and in emergency situations, natural or man-made, will serve as a protective structure to shelter mine workers. Heat-exchange modules can be made from mined-out or specially constructed tunnels. Economic analysis shows that the use of such multi-functional modules does not increase operation and maintenance costs, but enhances safety of mining operations and reliability in case of emergency situations. There are numerous theoretic and experimental investigations in the field of complex use of mining tunnels, which allows to develop regulatory design documents on their basis. Experience of practical application of heat-exchange tunnels has been assessed from the position of regulating heat regime in the mines.

  4. Manifestation of spin selection rules on the quantum tunneling of magnetization in a single-molecule magnet.

    Science.gov (United States)

    Henderson, J J; Koo, C; Feng, P L; del Barco, E; Hill, S; Tupitsyn, I S; Stamp, P C E; Hendrickson, D N

    2009-07-03

    We present low temperature magnetometry measurements on a new Mn3 single-molecule magnet in which the quantum tunneling of magnetization (QTM) displays clear evidence for quantum mechanical selection rules. A QTM resonance appearing only at high temperatures demonstrates tunneling between excited states with spin projections differing by a multiple of three. This is dictated by the C3 molecular symmetry, which forbids pure tunneling from the lowest metastable state. Transverse field resonances are understood by correctly orienting the Jahn-Teller axes of the individual manganese ions and including transverse dipolar fields. These factors are likely to be important for QTM in all single-molecule magnets.

  5. DNS Tunneling Detection Method Based on Multilabel Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Ahmed Almusawi

    2018-01-01

    Full Text Available DNS tunneling is a method used by malicious users who intend to bypass the firewall to send or receive commands and data. This has a significant impact on revealing or releasing classified information. Several researchers have examined the use of machine learning in terms of detecting DNS tunneling. However, these studies have treated the problem of DNS tunneling as a binary classification where the class label is either legitimate or tunnel. In fact, there are different types of DNS tunneling such as FTP-DNS tunneling, HTTP-DNS tunneling, HTTPS-DNS tunneling, and POP3-DNS tunneling. Therefore, there is a vital demand to not only detect the DNS tunneling but rather classify such tunnel. This study aims to propose a multilabel support vector machine in order to detect and classify the DNS tunneling. The proposed method has been evaluated using a benchmark dataset that contains numerous DNS queries and is compared with a multilabel Bayesian classifier based on the number of corrected classified DNS tunneling instances. Experimental results demonstrate the efficacy of the proposed SVM classification method by obtaining an f-measure of 0.80.

  6. Extruded Tunnel Lining System : Phase 1. Conceptual Design and Feasibility Testing.

    Science.gov (United States)

    1979-09-01

    The Extruded Tunnel Lining System (ETLS) has been conceived as a means of continuously placing the final concrete tunnel lining directly behind a tunnel boring machine. The system will shorten the time required to excavate and line a tunnel section, ...

  7. Comparison of femur tunnel aperture location in patients undergoing transtibial and anatomical single-bundle anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Lee, Dae-Hee; Kim, Hyun-Jung; Ahn, Hyeong-Sik; Bin, Seong-Il

    2016-12-01

    Although three-dimensional computed tomography (3D-CT) has been used to compare femoral tunnel position following transtibial and anatomical anterior cruciate ligament (ACL) reconstruction, no consensus has been reached on which technique results in a more anatomical position because methods of quantifying femoral tunnel position on 3D-CT have not been consistent. This meta-analysis was therefore performed to compare femoral tunnel location following transtibial and anatomical ACL reconstruction, in both the low-to-high and deep-to-shallow directions. This meta-analysis included all studies that used 3D-CT to compare femoral tunnel location, using quadrant or anatomical coordinate axis methods, following transtibial and anatomical (AM portal or OI) single-bundle ACL reconstruction. Six studies were included in the meta-analysis. Femoral tunnel location was 18 % higher in the low-to-high direction, but was not significant in the deep-to-shallow direction, using the transtibial technique than the anatomical methods, when measured using the anatomical coordinate axis method. When measured using the quadrant method, however, femoral tunnel positions were significantly higher (21 %) and shallower (6 %) with transtibial than anatomical methods of ACL reconstruction. The anatomical ACL reconstruction techniques led to a lower femoral tunnel aperture location than the transtibial technique, suggesting the superiority of anatomical techniques for creating new femoral tunnels during revision ACL reconstruction in femoral tunnel aperture location in the low-to-high direction. However, the mean difference in the deep-to-shallow direction differed by method of measurement. Meta-analysis, Level II.

  8. Airloads Correlation of the UH-60A Rotor Inside the 40- by 80-Foot Wind Tunnel

    Science.gov (United States)

    Chang, I-Chung; Norman, Thomas R.; Romander, Ethan A.

    2013-01-01

    The presented research validates the capability of a loosely-coupled computational fluid dynamics (CFD) and comprehensive rotorcraft analysis (CRA) code to calculate the flowfield around a rotor and test stand mounted inside a wind tunnel. The CFD/CRA predictions for the full-scale UH-60A Airloads Rotor inside the National Full-Scale Aerodynamics Complex (NFAC) 40- by 80-Foot Wind Tunnel at NASA Ames Research Center are compared with the latest measured airloads and performance data. The studied conditions include a speed sweep at constant lift up to an advance ratio of 0.4 and a thrust sweep at constant speed up to and including stall. For the speed sweep, wind tunnel modeling becomes important at advance ratios greater than 0.37 and test stand modeling becomes increasingly important as the advance ratio increases. For the thrust sweep, both the wind tunnel and test stand modeling become important as the rotor approaches stall. Despite the beneficial effects of modeling the wind tunnel and test stand, the new models do not completely resolve the current airload discrepancies between prediction and experiment.

  9. Airloads Correlation of the UH-60A Rotor inside the 40- by 80-Foot Wind Tunnel

    Directory of Open Access Journals (Sweden)

    I-Chung Chang

    2014-01-01

    Full Text Available The presented research validates the capability of a loosely coupled computational fluid dynamics (CFD and comprehensive rotorcraft analysis (CRA code to calculate the flowfield around a rotor and test stand mounted inside a wind tunnel. The CFD/CRA predictions for the Full-Scale UH-60A Airloads Rotor inside the National Full-Scale Aerodynamics Complex (NFAC 40- by 80-Foot Wind Tunnel at NASA Ames Research Center are compared with the latest measured airloads and performance data. The studied conditions include a speed sweep at constant lift up to an advance ratio of 0.4 and a thrust sweep at constant speed up to and including stall. For the speed sweep, wind tunnel modeling becomes important at advance ratios greater than 0.37 and test stand modeling becomes increasingly important as the advance ratio increases. For the thrust sweep, both the wind tunnel and test stand modeling become important as the rotor approaches stall. Despite the beneficial effects of modeling the wind tunnel and test stand, the new models do not completely resolve the current airload discrepancies between prediction and experiment.

  10. Phonon tunneling through a double barrier system

    Energy Technology Data Exchange (ETDEWEB)

    Villegas, Diosdado [Departamento de Física, Universidad Central “Marta Abreu” de Las Villas, CP 54830, Santa Clara, Villa Clara (Cuba); Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico); León-Pérez, Fernando de [Centro Universitario de la Defensa de Zaragoza, Ctra. de Huesca s/n, E-50090 Zaragoza (Spain); Pérez-Álvarez, R. [Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209 Cuernavaca (Mexico); Arriaga, J., E-mail: arriaga@ifuap.buap.mx [Instituto de Física, Universidad Autónoma de Puebla, 18 Sur y San Claudio, Edif. 110A, Ciudad Universitaria, 72570 Puebla (Mexico)

    2015-04-15

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices.

  11. Silicon spintronics with ferromagnetic tunnel devices

    International Nuclear Information System (INIS)

    Jansen, R; Sharma, S; Dash, S P; Min, B C

    2012-01-01

    In silicon spintronics, the unique qualities of ferromagnetic materials are combined with those of silicon, aiming at creating an alternative, energy-efficient information technology in which digital data are represented by the orientation of the electron spin. Here we review the cornerstones of silicon spintronics, namely the creation, detection and manipulation of spin polarization in silicon. Ferromagnetic tunnel contacts are the key elements and provide a robust and viable approach to induce and probe spins in silicon, at room temperature. We describe the basic physics of spin tunneling into silicon, the spin-transport devices, the materials aspects and engineering of the magnetic tunnel contacts, and discuss important quantities such as the magnitude of the spin accumulation and the spin lifetime in the silicon. We highlight key experimental achievements and recent progress in the development of a spin-based information technology. (topical review)

  12. Phonon tunneling through a double barrier system

    International Nuclear Information System (INIS)

    Villegas, Diosdado; León-Pérez, Fernando de; Pérez-Álvarez, R.; Arriaga, J.

    2015-01-01

    The tunneling of optical and acoustic phonons at normal incidence on a double-barrier is studied in this paper. Transmission coefficients and resonance conditions are derived theoretically under the assumption that the long-wavelength approximation is valid. It is shown that the behavior of the transmission coefficients for the symmetric double barrier has a Lorentzian form close to resonant frequencies and that Breit–Wigner's formula have a general validity in one-dimensional phonon tunneling. Authors also study the so-called generalized Hartman effect in the tunneling of long-wavelength phonons and show that this effect is a numerical artifact resulting from taking the opaque limit before exploring the variation with a finite barrier width. This study could be useful for the design of acoustic devices

  13. Positioning systems for underground tunnel environments

    CERN Document Server

    Leite Pereira, Fernando; Theis, Christian

    In the last years the world has witnessed a remarkable change in the computing concept by entering the mobile era. Incredibly powerful smartphones have proliferated at stunning pace and tablet computers are capable of running demanding applications and meet new business requirements. Being wireless, localization has become crucial not only to serve individuals but also help companies in industrial and safety processes. In the context of the Radiation Protection group at CERN, automatic localization, besides allowing to find people, would help improving the radiation surveys performed regularly along the accelerator tunnels. The research presented in this thesis attempts to answer questions relatively to the viability of localization in a harsh conditions tunnel: “Is localization in a very long tunnel possible, meeting its restrictions and without incurring prohibitive costs and infrastructure?”, “Can one achieve meter-level accuracy with GSM deployed over leaky-feeder?”, “Is it possible to prototype...

  14. Influence of safety measures on the risks of transporting dangerous goods through road tunnels.

    Science.gov (United States)

    Saccomanno, Frank; Haastrup, Palle

    2002-12-01

    Quantitative risk assessment (QRA) models are used to estimate the risks of transporting dangerous goods and to assess the merits of introducing alternative risk reduction measures for different transportation scenarios and assumptions. A comprehensive QRA model recently was developed in Europe for application to road tunnels. This model can assess the merits of a limited number of "native safety measures." In this article, we introduce a procedure for extending its scope to include the treatment of a number of important "nonnative safety measures" of interest to tunnel operators and decisionmakers. Nonnative safety measures were not included in the original model specification. The suggested procedure makes use of expert judgment and Monte Carlo simulation methods to model uncertainty in the revised risk estimates. The results of a case study application are presented that involve the risks of transporting a given volume of flammable liquid through a 10-km road tunnel.

  15. 47 CFR 15.211 - Tunnel radio systems.

    Science.gov (United States)

    2010-10-01

    ... regulations contained within this part. (c) The total electromagnetic field from a tunnel radio system on any... surrounding earth and/or water. (b) Any intentional or unintentional radiator external to the tunnel, mine or...

  16. Toward an Integrated Optical Data System for Wind Tunnel Testing

    National Research Council Canada - National Science Library

    Ruyten, Wim

    1999-01-01

    ...) of the test article in a wind tunnel test. The theory for such P&A determinations is developed and applied to data from a recent pressure sensitive paint test in AEDC's 16 ft transonic wind tunnel...

  17. A Top Pilot Tunnel Preconditioning Method for the Prevention of Extremely Intense Rockbursts in Deep Tunnels Excavated by TBMs

    Science.gov (United States)

    Zhang, Chuanqing; Feng, Xiating; Zhou, Hui; Qiu, Shili; Wu, Wenping

    2012-05-01

    The headrace tunnels at the Jinping II Hydropower Station cross the Jinping Mountain with a maximum overburden depth of 2,525 m, where 80% of the strata along the tunnels consist of marble. A number of extremely intense rockbursts occurred during the excavation of the auxiliary tunnels and the drainage tunnel. In particular, a tunnel boring machine (TBM) was destroyed by an extremely intense rockburst in a 7.2-m-diameter drainage tunnel. Two of the four subsequent 12.4-m-diameter headrace tunnels will be excavated with larger size TBMs, where a high risk of extremely intense rockbursts exists. Herein, a top pilot tunnel preconditioning method is proposed to minimize this risk, in which a drilling and blasting method is first recommended for the top pilot tunnel excavation and support, and then the TBM excavation of the main tunnel is conducted. In order to evaluate the mechanical effectiveness of this method, numerical simulation analyses using the failure approaching index, energy release rate, and excess shear stress indices are carried out. Its construction feasibility is discussed as well. Moreover, a microseismic monitoring technique is used in the experimental tunnel section for the real-time monitoring of the microseismic activities of the rock mass in TBM excavation and for assessing the effect of the top pilot tunnel excavation in reducing the risk of rockbursts. This method is applied to two tunnel sections prone to extremely intense rockbursts and leads to a reduction in the risk of rockbursts in TBM excavation.

  18. The effect of density-of-state tails on band-to-band tunneling: Theory and application to tunnel field effect transistors

    Science.gov (United States)

    Sant, S.; Schenk, A.

    2017-10-01

    It is demonstrated how band tail states in the semiconductor influence the performance of a Tunnel Field Effect Transistor (TFET). As a consequence of the smoothened density of states (DOS) around the band edges, the energetic overlap of conduction and valence band states occurs gradually at the onset of band-to-band tunneling (BTBT), thus degrading the sub-threshold swing (SS) of the TFET. The effect of the band tail states on the current-voltage characteristics is modelled quantum-mechanically based on the idea of zero-phonon trap-assisted tunneling between band and tail states. The latter are assumed to arise from a 3-dimensional pseudo-delta potential proposed by Vinogradov [1]. This model potential allows the derivation of analytical expressions for the generation rate covering the whole range from very strong to very weak localization of the tail states. Comparison with direct BTBT in the one-band effective mass approximation reveals the essential features of tail-to-band tunneling. Furthermore, an analytical solution for the problem of tunneling from continuum states of the disturbed DOS to states in the opposite band is found, and the differences to direct BTBT are worked out. Based on the analytical expressions, a semi-classical model is implemented in a commercial device simulator which involves numerical integration along the tunnel paths. The impact of the tail states on the device performance is analyzed for a nanowire Gate-All-Around TFET. The simulations show that tail states notably impact the transfer characteristics of a TFET. It is found that exponentially decaying band tails result in a stronger degradation of the SS than tail states with a Gaussian decay of their density. The developed model allows more realistic simulations of TFETs including their non-idealities.

  19. Wind tunnel tests of a free yawing downwind wind turbine

    DEFF Research Database (Denmark)

    Verelst, David Robert; Larsen, Torben J.; van Wingerden, Jan-Willem

    2014-01-01

    . The discussed test cases show that the turbine is stable while operating in free yawing conditions. Further, the effect of the tower shadow passage on the blade flapwise strain measurement is evaluated. Finally, data from the experiment is compared with preliminary simulations using DTU Wind Energy......This research paper presents preliminary results on a behavioural study of a free yawing downwind wind turbine. A series of wind tunnel tests was performed at the TU Delft Open Jet Facility with a three bladed downwind wind turbine and a rotor radius of 0.8 meters. The setup includes an off...

  20. Scanning Tunneling Microscopy analysis of space-exposed polymer films

    Science.gov (United States)

    Kalil, Carol R.; Young, Philip R.

    1993-01-01

    The characterization of the surface of selected space-exposed polymer films by Scanning Tunneling Microscopy (STM) is reported. Principles of STM, an emerging new technique for materials analysis, are reviewed. The analysis of several films which received up to 5.8 years of low Earth orbital (LEO) exposure onboard the NASA Long Duration Exposure Facility (LDEF) is discussed. Specimens included FEP Teflon thermal blanket material, Kapton film, and several experimental polymer films. Ultraviolet and atomic oxygen-induced crazing and erosion are described. The intent of this paper is to demonstrate how STM is enhancing the understanding of LEO space environmental effects on polymer films.

  1. Electric field effects in scanning tunneling microscope imaging

    DEFF Research Database (Denmark)

    Stokbro, Kurt; Quaade, Ulrich; Grey, Francois

    1998-01-01

    We present a high-voltage extension of the Tersoff-Hamann theory of scanning tunneling microscope (STM) images, which includes the effect of the electric field between the tip and the sample. The theoretical model is based on first-principles electronic structure calculations and has no adjustable...... parameters. We use the method to calculate theoretical STM images of the monohydrate Si(100)-H(2x1) surface with missing hydrogen defects at -2V and find an enhanced corrugation due to the electric field, in good agreement with experimental images....

  2. Low-frequency noise in single electron tunneling transistor

    DEFF Research Database (Denmark)

    Tavkhelidze, A.N.; Mygind, Jesper

    1998-01-01

    The noise in current biased aluminium single electron tunneling (SET) transistors has been investigated in the frequency range of 5 mHz shielding including resistive coaxial lines, that prevents spurious electromagnetic radiation and especially high energy......, we find the same input charge noise, typically QN = 5 × 10–4 e/Hz1/2 at 10 Hz, with and without the HF shielding. At lower frequencies, the noise is due to charge trapping, and the voltage noise pattern superimposed on the V(Vg) curve (voltage across transistor versus gate voltage) strongly depends...

  3. Minimally invasive carpal tunnel decompression using the KnifeLight.

    Science.gov (United States)

    Hwang, Peter Y K; Ho, Chi Long

    2007-02-01

    Carpal tunnel syndrome is a common condition causing hand pain, dysfunction, and paresthesia. Endoscopic carpal tunnel decompression offers many advantages compared with conventional open surgical decompression. However, it is equipment intensive and requires familiarity with endoscopic surgery. We review a minimally invasive technique to divide the flexor retinaculum by using a new instrument, the KnifeLight (Stryker, Kalamazoo, Michigan), which combines the advantages of the open and endoscopic methods, without the need for endoscopic set-up. Between July 2003 and April 2005, 44 consecutive patients (26 women [59%] and 18 men [36%]), with clinical signs and symptoms, as well as electrodiagnostic findings consistent with carpal tunnel syndrome, who did not respond to non-surgical treatment, underwent the new procedure. All patients were asked about scar hypertrophy, scar tenderness, and pillar pain. The Michigan Hand Outcomes Questionnaire (MHQ) was used to determine overall hand function, activities of daily living, work performance, pain, aesthetics, and satisfaction with hand function. Other preoperative testing included grip strength and lateral pinch strength. Grip strength was measured using the Jamar hand dynamometer (Asimov Engineering Co., Los Angeles, CA); lateral key pinch was measured using the Jamar hydraulic pinch gauge. Postoperative evaluations were scheduled at 2 weeks, 3 months, and 6 months after the procedure. A small 10-mm incision was made in the wrist crease and a small opening was made at the transverse carpal ligament. The KnifeLight tool was inserted, and the ligament was incised completely. Follow-up evaluations with use of quantitative measurements of grip strength, pinch strength, and hand dexterity were performed at 2 weeks, 3 months, and 6 months after surgery. Fifty procedures were performed on 22 left hands (44%) and 28 right hands (56%). There were no complications related to the approach. All patients were able to use their hands

  4. Wind Tunnel Measurements at LM Wind Power

    DEFF Research Database (Denmark)

    Bertagnolio, Franck

    2012-01-01

    This section presents the results obtained during the experimental campaign that was conducted in the wind tunnel at LM Wind Power in Lunderskov from August 16th to 26th, 2010. The goal of this study is to validate the so-called TNO trailing edge noise model through measurements of the boundary...... layer turbulence characteristics and the far-field noise generated by the acoustic scattering of the turbulent boundary layer vorticies as they convect past the trailing edge. This campaign was conducted with a NACA0015 airfoil section that was placed in the wind tunnel section. It is equipped with high...

  5. A study for the KAERI research tunnel

    International Nuclear Information System (INIS)

    Kim, J.; Hwang, Y. S.; Park, H. S.; Park, S. K.; Park, B. Y.; Bang, K. S.; Kuh, J. H.; Kang, K. H.

    1997-12-01

    Major goal of the R and D on the KAERI Research Tunnel in 1997 are 1) concept development of the KAERI research tunnel and its major units 2) computer simulation of facilities 3) study on thermo-hydro mechanical coupling in the vicinity of a waste repository 4) effect of excavated distrubed zone. In addition supplementary site investigation to understand the distribution of stresses in the site was done along with long term monitoring of the water table. (author). 44 refs., 16 tabs., 36 figs

  6. Application Of Artificial Intelligence To Wind Tunnels

    Science.gov (United States)

    Lo, Ching F.; Steinle, Frank W., Jr.

    1989-01-01

    Report discusses potential use of artificial-intelligence systems to manage wind-tunnel test facilities at Ames Research Center. One of goals of program to obtain experimental data of better quality and otherwise generally increase productivity of facilities. Another goal to increase efficiency and expertise of current personnel and to retain expertise of former personnel. Third goal to increase effectiveness of management through more efficient use of accumulated data. System used to improve schedules of operation and maintenance of tunnels and other equipment, assignment of personnel, distribution of electrical power, and analysis of costs and productivity. Several commercial artificial-intelligence computer programs discussed as possible candidates for use.

  7. Fire Resistant Panels for the Tunnel Linings

    Directory of Open Access Journals (Sweden)

    Gravit Marina

    2016-01-01

    Full Text Available Presents the results of studies of innovative materials in the field of experimental and theoretical research fire resistance fireproof panels Pyro-Safe Aestuver T. Owing to the assembly simplicity, materials cheapness, high ecological standard, recycling, reuse potential, are benefit. Research work is running to improve the knowledge about fireproof panels Pyro-Safe Aestuver T for tunnel lining, its basic performance, its long term behavior and in particular also its fire proof for example when used for the lining of road tunnels.

  8. Dielectric Engineered Tunnel Field-Effect Transistor

    OpenAIRE

    Ilatikhameneh, Hesameddin; Ameen, Tarek A.; Klimeck, Gerhard; Appenzeller, Joerg; Rahman, Rajib

    2015-01-01

    The dielectric engineered tunnel field-effect transistor (DE-TFET) as a high performance steep transistor is proposed. In this device, a combination of high-k and low-k dielectrics results in a high electric field at the tunnel junction. As a result a record ON-current of about 1000 uA/um and a subthreshold swing (SS) below 20mV/dec are predicted for WTe2 DE-TFET. The proposed TFET works based on a homojunction channel and electrically doped contacts both of which are immune to interface stat...

  9. Macroscopic quantum tunneling of the magnetic moment

    Science.gov (United States)

    Tejada, J.; Hernandez, J. M.; del Barco, E.

    1999-05-01

    In this paper we review the work done on magnetic relaxation during the last 10 years on both single-domain particles and magnetic molecules and its contribution to the discovery of quantum tunneling of the magnetic moment (Chudnovsky and Tejada, Macroscopic Quantum tunneling of the Magnetic moment, Cambridge University press, Cambridge, 1998). We present first the theoretical expressions and their connection to quantum relaxation and secondly, we show and discuss the experimental results. Finally, we discuss very recent hysteresis data on Mn 12Ac molecules at extremely large sweeping rate for the external magnetic field which suggest the existence of quantum spin—phonon avalanches.

  10. Microscopic tunneling theory of long Josephson junctions

    DEFF Research Database (Denmark)

    Grønbech-Jensen, N.; Hattel, Søren A.; Samuelsen, Mogens Rugholm

    1992-01-01

    We present a numerical scheme for solving a nonlinear partial integro-differential equation with nonlocal time dependence. The equation describes the dynamics in a long Josephson junction modeled by use of the microscopic theory for tunneling between superconductors. We demonstrate that the detai......We present a numerical scheme for solving a nonlinear partial integro-differential equation with nonlocal time dependence. The equation describes the dynamics in a long Josephson junction modeled by use of the microscopic theory for tunneling between superconductors. We demonstrate...... that the detailed behavior of a solitonic mode (fluxon dynamics) in the junction is different from the results of the conventional perturbed sine-Gordon model....

  11. Quantum dot resonant tunneling diode single photon detector with aluminum oxide aperture defined tunneling area

    DEFF Research Database (Denmark)

    Li, H.W.; Kardynal, Beata; Ellis, D.J.P.

    2008-01-01

    Quantum dot resonant tunneling diode single photon detector with independently defined absorption and sensing areas is demonstrated. The device, in which the tunneling is constricted to an aperture in an insulating layer in the emitter, shows electrical characteristics typical of high quality...... resonant tunneling diodes. A single photon detection efficiency of 2.1%+/- 0.1% at 685 nm was measured corresponding to an internal quantum efficiency of 14%. The devices are simple to fabricate, robust, and show promise for large absorption area single photon detectors based on quantum dot structures....

  12. Microwave-induced co-tunneling in single electron tunneling transistors

    DEFF Research Database (Denmark)

    Ejrnaes, M.; Savolainen, M.; Manscher, M.

    2002-01-01

    on rubber bellows. Cross-talk was minimized by using individual coaxial lines between the sample and the room temperature electronics: The co-tunneling experiments were performed at zero DC bias current by measuring the voltage response to a very small amplitude 2 Hz current modulation with the gate voltage......The influence of microwaves on the co-tunneling in single electron tunneling transistors has been investigated as function of frequency and power in the temperature range from 150 to 500 mK. All 20 low frequency connections and the RF line were filtered, and the whole cryostat was suspended...

  13. Efficient logistics enabled by smart solutions in tunneling

    OpenAIRE

    Zakaria Dakhli; Zoubeir Lafhaj

    2017-01-01

    While logistics comprises an important part of tunneling costs, it is generally not considered a lever of performance but rather a constraint to a project's progress. This study presents some insights on how smart technology can impact the tunneling industry. The impact is even greater because of the complexity of the tunneling supply chain, and smart technology could help support this process. Finally, we discuss how the nature of the tunneling industry invites stakeholders to develop a comm...

  14. Band-to-Band Tunneling Transistors: Scalability and Circuit Performance

    Science.gov (United States)

    2013-05-01

    55* MEDICI ...3.2.1 Tunneling Theory 3.3 Simulation Methods 3.3.1 MEDICI 3.3.2 Sentaurus Local Tunneling 3.3.3 Sentaurus Nonlocal Tunneling 3.4 Sentaurus...tunneling current. 3.3.1 MEDICI MEDICI is a one and two-dimensional simulator created by Synopsys, Inc. [18]. It contains a band-to-band

  15. 2D Vertical Heterostructures for Novel Tunneling Device Applications

    Science.gov (United States)

    2017-03-01

    tunneling has been explored for the symmetric field - effect transistor (symFET) [1, 2], while opposite-band tunneling has been explored for...the interlayer tunnel field - effect transistor (ITFET) [3, 4] and the Esaki diode [5]. Figure 1. (a) Schematic of the heterostructure, with the... Tunneling Field Effect Transistor ," Journal of Applied Physics, vol. 115, p. 074508, 2014. [4] M. O. Li, D. Esseni, J. J. Nahas, D.

  16. Tunnelling conductive hybrid films of gold nanoparticles and cellulose and their applications as electrochemical electrodes

    International Nuclear Information System (INIS)

    Liu, Zhiming; Wang, Xuefeng; Wu, Wenjian; Li, Mei

    2015-01-01

    Conductive hybrid films of metal nanoparticles and polymers have practical applications in the fields of sensing, microelectronics and catalysis, etc. Herein, we present the electrochemical availability of tunnelling conductive hybrid films of gold nanoparticles (GNPs) and cellulose. The hybrid films were provided with stable tunnelling conductive properties with 12 nm GNPs of 12.7% (in weight). For the first time, the conductive hybrid films were used as substrates of electrochemical electrodes to load calmodulin (CaM) proteins for sensing of calcium cations. The electrodes of hybrid films with 20 nm GNPs of 46.7% (in weight) exhibited stable electrochemical properties, and showed significant responses to calcium cations with concentrations as low as 10 −9 M after being loaded with CaM proteins. (paper)

  17. Spin polarization at the interface and tunnel magnetoresistance

    International Nuclear Information System (INIS)

    Itoh, H.; Inoue, J.

    2001-01-01

    We propose that interfacial states of imperfectly oxidized Al ions may exist in ferromagnetic tunnel junctions with Al-O barrier and govern both the spin polarization and tunnel conductance. It is shown that the spin polarization is positive independent of materials and correlates well with the tunnel magnetoresistance

  18. Wound geometry as it relates to tunnel valvular competence in ...

    African Journals Online (AJOL)

    Results: Valvularly competent sclerocorneal tunnel largely contributes to the outcome of sutureless MSICS and takes practice to master. Conclusion: Core to a successful MSICS is the construction of a leak-proof sclerocorneal tunnel. Keywords: Incision anatomy, incisional funnel, sclerocorneal pockets, sclerocorneal tunnel ...

  19. Numerical analysis of surface subsidence in asymmetric parallel highway tunnels

    Directory of Open Access Journals (Sweden)

    Ratan Das

    2017-02-01

    Full Text Available Tunnelling related hazards are very common in the Himalayan terrain and a number of such instances have been reported. Several twin tunnels are being planned for transportation purposes which will require good understanding for prediction of tunnel deformation and surface settlement during the engineering life of the structure. The deformational behaviour, design of sequential excavation and support of any jointed rock mass are challenging during underground construction. We have raised several commonly assumed issues while performing stability analysis of underground opening at shallow depth. For this purpose, Kainchi-mod Nerchowck twin tunnels (Himachal Pradesh, India are taken for in-depth analysis of the stability of two asymmetric tunnels to address the influence of topography, twin tunnel dimension and geometry. The host rock encountered during excavation is composed mainly of moderately to highly jointed grey sandstone, maroon sandstone and siltstones. In contrast to equidimensional tunnels where the maximum subsidence is observed vertically above the centreline of the tunnel, the result from the present study shows shifting of the maximum subsidence away from the tunnel centreline. The maximum subsidence of 0.99 mm is observed at 4.54 m left to the escape tunnel centreline whereas the maximum subsidence of 3.14 mm is observed at 8.89 m right to the main tunnel centreline. This shifting clearly indicates the influence of undulating topography and in-equidimensional noncircular tunnel.

  20. Resonance-like tunneling across a barrier with adjacent wells

    Indian Academy of Sciences (India)

    devices using n-type oxygen-doped gallium arsenide and silicon dioxide. It is envisaged that these results will have applications in the design of tunneling devices. Keywords. Potential barrier with wells; tunneling; resonance. PACS Nos 03.65.-w; 03.65.Xp. 1. Introduction. The mechanism of quantum tunneling (T) across ...

  1. A tilting wind tunnel for fire behavior studies

    Science.gov (United States)

    David R. Weise

    1994-01-01

    The combined effects of wind velocity and slope on wildland fire behavior can be studied in the laboratory using a tilting wind tunnel. The tilting wind tunnel requires a commercially available fan to induce wind and can be positioned to simulate heading and backing fires spreading up and down slope. The tunnel is portable and can be disassembled for transport using a...

  2. Tunneling time distribution by means of Nelson's quantum ...

    Indian Academy of Sciences (India)

    Abstract. We construct a tunneling time distribution by means of Nelson's quantum mechanics and investigate statistical properties of the tunneling time distribution. As a result, we find that the relationship between the average and the variance of the tunneling time shows 'wave-particle duality'.

  3. Tunnel operator training with a conversational agent-assistant

    NARCIS (Netherlands)

    Buiel, E.; Lubbers, J.; Doesburg, W. van; Muller, T.

    2009-01-01

    A tunnel operator monitors and regulates the flow of traffic inside a tunnel. Tunnel operators need to train in a simulator regularly in order to maintain proficiency in handling incident situations. During quiet working hours, the operator has enough time for training. But generally at that time no

  4. Extreme Mutation Tolerance: Nearly Half of the Archaeal Fusellovirus Sulfolobus Spindle-Shaped Virus 1 Genes Are Not Required for Virus Function, Including the Minor Capsid Protein Gene vp3.

    Science.gov (United States)

    Iverson, Eric A; Goodman, David A; Gorchels, Madeline E; Stedman, Kenneth M

    2017-05-15

    Viruses infecting the Archaea harbor a tremendous amount of genetic diversity. This is especially true for the spindle-shaped viruses of the family Fuselloviridae , where >90% of the viral genes do not have detectable homologs in public databases. This significantly limits our ability to elucidate the role of viral proteins in the infection cycle. To address this, we have developed genetic techniques to study the well-characterized fusellovirus Sulfolobus spindle-shaped virus 1 (SSV1), which infects Sulfolobus solfataricus in volcanic hot springs at 80°C and pH 3. Here, we present a new comparative genome analysis and a thorough genetic analysis of SSV1 using both specific and random mutagenesis and thereby generate mutations in all open reading frames. We demonstrate that almost half of the SSV1 genes are not essential for infectivity, and the requirement for a particular gene correlates well with its degree of conservation within the Fuselloviridae The major capsid gene vp1 is essential for SSV1 infectivity. However, the universally conserved minor capsid gene vp3 could be deleted without a loss in infectivity and results in virions with abnormal morphology. IMPORTANCE Most of the putative genes in the spindle-shaped archaeal hyperthermophile fuselloviruses have no sequences that are clearly similar to characterized genes. In order to determine which of these SSV genes are important for function, we disrupted all of the putative genes in the prototypical fusellovirus, SSV1. Surprisingly, about half of the genes could be disrupted without destroying virus function. Even deletions of one of the known structural protein genes that is present in all known fuselloviruses, vp3 , allows the production of infectious viruses. However, viruses lacking vp3 have abnormal shapes, indicating that the vp3 gene is important for virus structure. Identification of essential genes will allow focused research on minimal SSV genomes and further understanding of the structure of

  5. A Method for Dynamic Risk Assessment and Management of Rockbursts in Drill and Blast Tunnels

    Science.gov (United States)

    Liu, Guo-Feng; Feng, Xia-Ting; Feng, Guang-Liang; Chen, Bing-Rui; Chen, Dong-Fang; Duan, Shu-Qian

    2016-08-01

    Focusing on the problems caused by rockburst hazards in deep tunnels, such as casualties, damage to construction equipment and facilities, construction schedule delays, and project cost increase, this research attempts to present a methodology for dynamic risk assessment and management of rockbursts in D&B tunnels. The basic idea of dynamic risk assessment and management of rockbursts is determined, and methods associated with each step in the rockburst risk assessment and management process are given, respectively. Among them, the main parts include a microseismic method for early warning the occurrence probability of rockburst risk, an estimation method that aims to assess potential consequences of rockburst risk, an evaluation method that utilizes a new quantitative index considering both occurrence probability and consequences for determining the level of rockburst risk, and the dynamic updating. Specifically, this research briefly describes the referenced microseismic method of warning rockburst, but focuses on the analysis of consequences and associated risk assessment and management of rockburst. Using the proposed method of risk assessment and management of rockburst, the occurrence probability, potential consequences, and the level of rockburst risk can be obtained in real-time during tunnel excavation, which contributes to the dynamic optimisation of risk mitigation measures and their application. The applicability of the proposed method has been verified by those cases from the Jinping II deep headrace and water drainage tunnels at depths of 1900-2525 m (with a length of 11.6 km in total for D&B tunnels).

  6. Seismic Design of a Single Bored Tunnel: Longitudinal Deformations and Seismic Joints

    Science.gov (United States)

    Oh, J.; Moon, T.

    2018-03-01

    The large diameter bored tunnel passing through rock and alluvial deposits subjected to seismic loading is analyzed for estimating longitudinal deformations and member forces on the segmental tunnel liners. The project site has challenges including high hydrostatic pressure, variable ground profile and high seismic loading. To ensure the safety of segmental tunnel liner from the seismic demands, the performance-based two-level design earthquake approach, Functional Evaluation Earthquake and Safety Evaluation Earthquake, has been adopted. The longitudinal tunnel and ground response seismic analyses are performed using a three-dimensional quasi-static linear elastic and nonlinear elastic discrete beam-spring elements to represent segmental liner and ground spring, respectively. Three components (longitudinal, transverse and vertical) of free-field ground displacement-time histories evaluated from site response analyses considering wave passage effects have been applied at the end support of the strain-compatible ground springs. The result of the longitudinal seismic analyses suggests that seismic joint for the mitigation measure requiring the design deflection capacity of 5-7.5 cm is to be furnished at the transition zone between hard and soft ground condition where the maximum member forces on the segmental liner (i.e., axial, shear forces and bending moments) are induced. The paper illustrates how detailed numerical analyses can be practically applied to evaluate the axial and curvature deformations along the tunnel alignment under difficult ground conditions and to provide the seismic joints at proper locations to effectively reduce the seismic demands below the allowable levels.

  7. Hybrid tunnel junction contacts to III–nitride light-emitting diodes

    KAUST Repository

    Young, Erin C.

    2016-01-26

    In this work, we demonstrate highly doped GaN p–n tunnel junction (TJ) contacts on III–nitride heterostructures where the active region of the device and the top p-GaN layers were grown by metal organic chemical vapor deposition and highly doped n-GaN was grown by NH3 molecular beam epitaxy to form the TJ. The regrowth interface in these hybrid devices was found to have a high concentration of oxygen, which likely enhanced tunneling through the diode. For optimized regrowth, the best tunnel junction device had a total differential resistivity of 1.5 × 10−4 Ω cm2, including contact resistance. As a demonstration, a blue-light-emitting diode on a ($20\\\\bar{2}\\\\bar{1}$) GaN substrate with a hybrid tunnel junction and an n-GaN current spreading layer was fabricated and compared with a reference sample with a transparent conducting oxide (TCO) layer. The tunnel junction LED showed a lower forward operating voltage and a higher efficiency at a low current density than the TCO LED.

  8. Voids at the tunnel-soil interface for calculation of ground vibration from underground railways

    Science.gov (United States)

    Jones, Simon; Hunt, Hugh

    2011-01-01

    Voids at the tunnel-soil interface are not normally considered when predicting ground vibration from underground railways. The soil is generally assumed to be continuously bonded to the outer surface of the tunnel to simplify the modelling process. Evidence of voids around underground railways motivated the study presented herein to quantify the level of uncertainty in ground vibration predictions associated with neglecting to include such voids at the tunnel-soil interface. A semi-analytical method is developed which derives discrete transfers for the coupled tunnel-soil model based on the continuous Pipe-in-Pipe method. The void is simulated by uncoupling the appropriate nodes at the interface to prevent force transfer between the systems. The results from this investigation show that relatively small voids ( 4 m×90∘) can significantly affect the rms velocity predictions in the near-field and moderately affect predictions in the far-field. Sensitivity of the predictions to void length and void sector angle are both deemed to be significant. The findings from this study suggest that the uncertainty associated with assuming a perfect bond at the tunnel-soil interface in an area with known voidage can reasonably reach ±5 dB and thus should be considered in the design process.

  9. Macroscopic quantum tunneling of a Bose-Einstein condensate through double Gaussian barriers

    Science.gov (United States)

    Maeda, Kenji; Urban, Gregor; Weidemüller, Matthias; Carr, Lincoln D.

    2015-05-01

    Macroscopic quantum tunneling is one of the great manifestations of quantum physics, not only showing passage through a potential barrier but also emerging in a many-body wave function. We study a quasi-1D Bose-Einstein condensate of Lithium, confined by two Gaussian barriers, and show that in an experimentally realistic potential tens of thousands of atoms tunnel on time scales of 10 to 100 ms. Using a combination of variational and WKB approximations based on the Gross-Pitaevskii or nonlinear Schrödinger equation, we show that many unusual tunneling features appear due to the nonlinearity, including the number of trapped atoms exhibiting non-exponential decay, severe distortion of the barriers by the mean field, and even formation of a triple barrier in certain regimes. In the first 10ms, nonlinear many-body effects make the tunneling rates significantly larger than background loss rates, from 10 to 70 Hz. Thus we conclude that macroscopic quantum tunneling can be observed on experimental time scales. Funded by NSF, AFOSR, the Alexander von Humboldt foundation, and the Heidelberg Center for Quantum Dynamics.

  10. Percutaneous Creation of Bare Intervascular Tunnels for Salvage of Thrombosed Hemodialysis Fistulas Without Recanalizable Outflow

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Matt Chiung-Yu, E-mail: jjychen@gmail.com [Yuan’s General Hospital, Department of Interventional Radiology (China); Wang, Yen-Chi [E-Da Hospital, Department of Radiology (China); Weng, Mei-Jui [Kaohsiung Veterans General Hospital, Department of Radiology (China)

    2015-08-15

    PurposeThis study aimed to retrospectively assess the efficacy of a bare intervascular tunnel for salvage of a thrombosed hemodialysis fistula. We examined the clinical outcomes and provided follow-up images of the bare intervascular tunnel.Materials and MethodsEight thrombosed fistulas lacked available recanalizable outflow veins were included in this study. These fistulas were salvaged by re-directing access site flow to a new outflow vein through a percutaneously created intervascular tunnel without stent graft placement. The post-intervention primary and secondary access patency rates were calculated using the Kaplan–Meier method.ResultsThe procedural and clinical success rates were 100 %. Post-intervention primary and secondary access patency at 300 days were 18.7 ± 15.8 and 87.5 ± 11.7 %, respectively. The mean follow-up period was 218.7 days (range 10–368 days). One patient died of acute myocardial infarction 10 days after the procedure. No other major complications were observed. Minor complications, such as swelling, ecchymosis, and pain around the tunnel, occurred in all of the patients.ConclusionsPercutaneous creation of a bare intervascular tunnel is a treatment option for thrombosed hemodialysis fistulas without recanalizable outflow in selected patients.

  11. Effective action of a compressible quantum Hall state edge: Application to tunneling

    International Nuclear Information System (INIS)

    Levitov, L. S.; Shytov, A. V.; Halperin, B. I.

    2001-01-01

    The electrodynamical response of the edge of a compressible quantum Hall system affects tunneling into the edge. Using composite Fermi liquid theory, we derive an effective action for the edge modes interacting with tunneling charge. This action generalizes the chiral Luttinger liquid theory of the quantum Hall edge to compressible systems in which transport is characterized by a finite Hall angle. In addition to the standard terms, the action contains a dissipative term. The tunneling exponent is calculated as a function of the filling fraction for several models, including screened and unscreened long-range Coulomb interaction, as well as a short-range interaction. We find that tunneling exponents are robust and to a large extent insensitive to the particular model. We discuss recent tunneling measurements in overgrown cleaved edge systems, and demonstrate that the profile of charge density near the edge is very sensitive to the parameters of the system. In general, the density is nonmonotonic, and can deviate from the bulk value by up to 30%. Implications for the correspondence to chiral Luttinger edge theories are discussed

  12. Pioneering Russian wind tunnels and first experimental investigations, 1871-1915

    Science.gov (United States)

    Gorbushin, A. R.

    2017-11-01

    A review of foreign and Russian sources is given mentioning the pioneering wind tunnels built in Russia at the turn of 19th and 20th centuries. The first wind tunnel in Russia was constructed by V.A. Pashkevich at the Mikhailovsky Artillery Academy in St. Petersburg in 1871. In total from 1871 through 1915, 18 wind tunnels were constructed in Russia: 11 in Moscow, 5 in St. Petersburg and 2 in Kaluga. An overview of the pioneering Russian wind tunnels built by V.A. Pashkevich, K.E. Tsiolkovsky, prof. N.E. Zhukovsky, D.P. Ryabushinsky and prof. K.P. Boklevsky is given. Schemes, photographs, formulas, description of the research and test results taken from the original papers published by the wind tunnel designers are given. Photographs from the N.E. Zhukovsky Scientific and Memorial Museum and the Archive of the Russian Academy of Sciences are used in the article. Methods of flow visualization and results of their application are presented. The Russian scientists and researchers' contribution to the development of techniques and methods of aerodynamic experiment is shown, including one of the most important aspects - the wall interference problem.

  13. Energy-Saving Tunnel Illumination System Based on LED's Intelligent Control

    International Nuclear Information System (INIS)

    Guo Shanshan; Wu Lan; Gu Hanting; Jiang Shuixiu

    2011-01-01

    At present there is a lot of electric energy wastage in tunnel illumination, whose design is based on the maximum brightness outside and the maximum vehicle speed all year round. LED's energy consumption is low, and the control of its brightness is simple and effective. It can be quickly adjusted between 0-100% of its maximum brightness, and will not affect the service life. Therefore, using LED as tunnel's illumination source, we can achieve a good energy saving effect. According to real-time data acquisition of vehicle speed, traffic flow and brightness outside the tunnel, the auto real-time control of tunnel illumination can be achieved. And the system regulated the LED luminance by means of combination of LED power module and intelligent control module. The tunnel information was detected by inspection equipments, which included luminometer, vehicle detector, and received by RTU(Remote Terminal Unit), then synchronously transmitted to PC. After data processing, RTU emitted the dimming signal to the LED driver to adjust the brightness of LED. Despite the relatively high cost of high-power LED lights, the enormous energy-saving effect and the well-behaved controllability is beyond compare to other lighting devices.

  14. Anomalous Tunnel Magnetoresistance and Spin Transfer Torque in Magnetic Tunnel Junctions with Embedded Nanoparticles

    Science.gov (United States)

    Useinov, Arthur; Ye, Lin-Xiu; Useinov, Niazbeck; Wu, Te-Ho; Lai, Chih-Huang

    2015-01-01

    The tunnel magnetoresistance (TMR) in the magnetic tunnel junction (MTJ) with embedded nanoparticles (NPs) was calculated in range of the quantum-ballistic model. The simulation was performed for electron tunneling through the insulating layer with embedded magnetic and non-magnetic NPs within the approach of the double barrier subsystem connected in parallel to the single barrier one. This model can be applied for both MTJs with in-plane magnetization and perpendicular one. We also calculated the in-plane component of the spin transfer torque (STT) versus the applied voltage in MTJs with magnetic NPs and determined that its value can be much larger than in single barrier system (SBS) for the same tunneling thickness. The reported simulation reproduces experimental data of the TMR suppression and peak-like TMR anomalies at low voltages available in leterature. PMID:26681336

  15. Theoretical consideration of spin-polarized resonant tunneling in magnetic tunnel junctions

    International Nuclear Information System (INIS)

    Mu Haifeng; Zhu Zhengang; Zheng Qingrong; Jin Biao; Wang Zhengchuan; Su Gang

    2004-01-01

    A recent elegant experimental realization [S. Yuasa et al., Science 297 (2002) 234] of the spin-polarized resonant tunneling in magnetic tunnel junctions is interpreted in terms of a two-band model. It is shown that the tunnel magnetoresistance (TMR) decays oscillatorily with the thickness of the normal metal (NM) layer, being fairly in agreement with the experimental observation. The tunnel conductance is found to decay with slight oscillations with the increase of the NM layer thickness, which is also well consistent with the experiment. In addition, when the magnetizations of both ferromagnet electrodes are not collinearly aligned, TMR is found to exhibit sharp resonant peaks at some particular thickness of the NM layer. The peaked TMR obeys nicely a Gaussian distribution against the relative orientation of the magnetizations

  16. Asymmetric voltage behavior of the tunnel magnetoresistance in double barrier magnetic tunnel junctions

    KAUST Repository

    Useinov, Arthur

    2012-06-01

    In this paper, we study the value of the tunnel magnetoresistance (TMR) as a function of the applied voltage in double barrier magnetic tunnel junctions (DMTJs) with the left and right ferromagnetic (FM) layers being pinned and numerically estimate the possible difference of the TMR curves for negative and positive voltages in the homojunctions (equal barriers and electrodes). DMTJs are modeled as two single barrier junctions connected in series with consecutive tunneling (CST). We investigated the asymmetric voltage behavior of the TMR for the CST in the range of a general theoretical model. Significant asymmetries of the experimental curves, which arise due to different annealing regimes, are mostly explained by different heights of the tunnel barriers and asymmetries of spin polarizations in magnetic layers. © (2012) Trans Tech Publications.

  17. Resonant tunnel magnetoresistance in double-barrier planar magnetic tunnel junctions

    KAUST Repository

    Useinov, A. N.

    2011-08-24

    We present a theoretical approach to calculate the spin-dependent current and tunnel magnetoresistance (TMR) in a double-barrier magnetic tunnel junction (DMTJ), in which the magnetization of the middle ferromagnetic metal layer can be aligned parallel or antiparallel in relation to the fixed magnetizations of the left and right ferromagnetic electrodes. The electron transport through the DMTJ is considered as a three-dimensional problem, taking into account all transmitting electron trajectories as well as the spin-dependent momentum conservation law. The dependence of the transmission coefficient and spin-polarized currents on the applied voltage is derived as an exact solution to the quantum-mechanical problem for the spin-polarized transport. In the range of the developed physical model, the resonant tunneling, nonresonant tunneling, and enhanced spin filtering can be explained; the simulation results are in good agreement with experimental data.

  18. Silicon-germanium nanowire tunnel-FETs with homo- and heterostructure tunnel junctions

    Science.gov (United States)

    Richter, S.; Blaeser, S.; Knoll, L.; Trellenkamp, S.; Fox, A.; Schäfer, A.; Hartmann, J. M.; Zhao, Q. T.; Mantl, S.

    2014-08-01

    Experimental results on tunneling field-effect transistors (TFETs) based on strained SiGe on SOI nanowire arrays are presented. A heterostructure SiGe/Si TFET with a vertical tunnel junction consisting of an in situ doped SiGe source and a Si channel with a minimum inverse subthreshold slope of 90 mV/dec is demonstrated. An increase in tunneling area results in higher on-current. The in situ doped heterojunction TFET shows great improvement compared to a homojunction SiGe on SOI nanowire design with implanted junctions. Temperature dependent measurements and device simulations are performed in order to analyze the tunnel transport mechanism in the devices.

  19. Electrically tunable tunneling rectification magnetoresistance in magnetic tunneling junctions with asymmetric barriers.

    Science.gov (United States)

    Wang, Jing; Huang, Qikun; Shi, Peng; Zhang, Kun; Tian, Yufeng; Yan, Shishen; Chen, Yanxue; Liu, Guolei; Kang, Shishou; Mei, Liangmo

    2017-10-26

    The development of multifunctional spintronic devices requires simultaneous control of multiple degrees of freedom of electrons, such as charge, spin and orbit, and especially a new physical functionality can be realized by combining two or more different physical mechanisms in one specific device. Here, we report the realization of novel tunneling rectification magnetoresistance (TRMR), where the charge-related rectification and spin-dependent tunneling magnetoresistance are integrated in Co/CoO-ZnO/Co magnetic tunneling junctions with asymmetric tunneling barriers. Moreover, by simultaneously applying direct current and alternating current to the devices, the TRMR has been remarkably tuned in the range from -300% to 2200% at low temperature. This proof-of-concept investigation provides an unexplored avenue towards electrical and magnetic control of charge and spin, which may apply to other heterojunctions to give rise to more fascinating emergent functionalities for future spintronics applications.

  20. Spin Tunneling in Junctions with Disordered Ferromagnets

    NARCIS (Netherlands)

    Paluskar, P.V.; Attema, J.J.; de Wijs, G.A.; Fiddy, S.; Snoeck, E.; Kohlhepp, J.T.; Swagten, H.J.M.; de Groot, R. A.; Koopmans, H.

    2008-01-01

    We provide compelling evidence to establish that, contrary to one’s elementary guess, the tunneling spin polarization (TSP) of amorphous CoFeB is larger than that of fcc CoFeB. First-principles atomic and electronic structure calculations reveal striking agreement between the measured TSP and the

  1. Resonant tunneling in a pulsed phonon field

    DEFF Research Database (Denmark)

    Kral, P.; Jauho, Antti-Pekka

    1999-01-01

    , The nonequilibrium spectral function for the resonance displays the formation and decay of the phonon sidebands on ultrashort time scales. The time-dependent tunneling current through the individual phonon satellites reflects this quasiparticle formation by oscillations, whose time scale is set by the frequency...

  2. Tunneling of electrons through semiconductor superlattices

    Indian Academy of Sciences (India)

    Unknown

    Abstract. The purpose of the present paper is to report a study of tunneling of electrons through semicon- ductor superlattices (SSL); specially, we have analysed diverse features of transmission coefficient of SSL. The SSL we have considered is Ga0⋅7Al0⋅3As–GaAs which has been drawing considerable attention during ...

  3. Tunneling of trapped-atom Bose condensates

    Indian Academy of Sciences (India)

    Tunneling of trapped-atom Bose condensates. SUBODH R SHENOY. Abdus Salam International Centre for Theoretical Physics, P.O. Box 586, Trieste 34100, Italy. Abstract. We obtain the dynamics in number and phase difference, for Bose condensates that tun- nel between two wells of a double-well atomic trap, using the ...

  4. Dark matter searches at the Canfranc tunnel

    International Nuclear Information System (INIS)

    Sarsa, M.L.; Avignone, F.T.; Brodzinski, R.L.; Cerezo, E.; Collar, J.I.; Garcia, E.; Reeves, J.H.; Miley, H.S.; Morales, A.; Morales, J.; Nunez-Lagos, R.; Ortiz de Solorzano, A.; Puimedon, J.; Saenz, C.; Salinas, A.; Villar, J.A.

    1994-01-01

    Results of an on-going search for particle dark matter with a germanium detector at the Canfranc tunnel are reported. Contour limits for cross-sections, masses and local halo densities of particles interacting through spin-independent interactions are presented. Preliminary results and prospects of a search for timing modulation of the signal are also reported. ((orig.))

  5. Nonlinear tunneling in two-dimensional lattices

    Czech Academy of Sciences Publication Activity Database

    Brazhnyi, V. A.; Konotop, V. V.; Kuzmiak, Vladimír; Shchesnovich, V. S.

    2007-01-01

    Roč. 76, č. 2 (2007), 023608.1-023608.14 ISSN 1050-2947 R&D Projects: GA MŠk(CZ) OC P11.001 Institutional research plan: CEZ:AV0Z20670512 Keywords : Bose -WEinstein condensation * tunnelling Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.893, year: 2007

  6. High-Performance Single Nanowire Tunnel Diodes

    DEFF Research Database (Denmark)

    Wallentin, Jesper; Persson, Johan Mikael; Wagner, Jakob Birkedal

    2010-01-01

    We demonstrate single nanowire tunnel diodes with room temperature peak current densities of up to 329 A/cm(2). Despite the large surface to volume ratio of the type-II InP-GaAs axial heterostructure nanowires, we measure peak to valley current ratios (PVCR) of up to 8.2 at room temperature and 27...

  7. B-Target Room Tunnel Redesigned

    Energy Technology Data Exchange (ETDEWEB)

    Esfandiari, Reza; /San Jose State U. /SLAC

    2010-08-25

    Several groups at SLAC National Accelerator Laboratory are currently working on a RF Modulator prototype for a future linear collider known as the International Linear Collider (ILC). The ILC runs using about a 1000 Klystrons which create high power carrier waves for the particle acceleration. Klystrons receive their electrical input power from modulators. In order to move beyond the prototype phase, the laboratory might expand its ground base further down a tunnel located at the End Station B (ESB) in order to house four new Klystron Modulator Test Stations. This area is known as the B-Target Room Tunnel, and the task was to redesign the tunnel layout for the upcoming changes. The project first began by collecting substantial amount of information about the prototyped project, the tunnel and the researchers feedback of what they would like to see in the upcoming design. Subsequent to numerous planning and presentations, one particular design was. Calculations for this design were then performed for the most complex aspects of the project. Based on the results of the calculations, specific sample beams, welds, bolts and materials were chosen for the possible future construction.

  8. Wind Tunnel Measurements at Virginia Tech

    DEFF Research Database (Denmark)

    Fischer, Andreas; Bertagnolio, Franck

    2012-01-01

    In this section, the wind tunnel configuration used for aerodynamic and aeroacoustic measurement is described. Then, the validation of the method for evaluating far-field noise from surface microphones as described in Section 5 is presented. Finally, the design concept proposed in Section 6 is ve...

  9. Dynamic response of tunnels in jointed rocks

    International Nuclear Information System (INIS)

    Heuze, F.E.; Shaffer, R.J.; Walton, O.R.; Maddix, D.M.

    1992-03-01

    We describe the application of the Discrete Element Method (DEM) to the dynamic analysis of the response of tunnels in jointed rocks to earthquake loading. In situations where large motions of many blocks and collapse occur, the discontinuum-based DEM approach appears superior to other methods of analysis

  10. Decompression of magma into repository tunnels

    NARCIS (Netherlands)

    Bokhove, Onno; Woods, A.W.

    2002-01-01

    It is nontrivial to find and design safe repository sites for nuclear waste. It appears common sense to drill tunnels as repository sites in a mountain in remote and relatively dry regions. However, erosion of the waste canisters by naturally abundant chemicals in the mountains water cycle remains a

  11. Tunneling of trapped-atom Bose condensates

    Indian Academy of Sciences (India)

    We obtain the dynamics in number and phase difference, for Bose condensates that tunnel between two wells of a double-well atomic trap, using the (nonlinear) Gross–Pitaevskii equation. The dynamical equations are of the canonical form for the two conjugate variables, and the Hamiltonian corresponds to that of a ...

  12. Low temperature delayed recombinationand trap tunneling

    Czech Academy of Sciences Publication Activity Database

    Mihóková, Eva; Schulman, L. S.

    2015-01-01

    Roč. 27, č. 7 (2015), 1-8 ISSN 0953-8984 Grant - others:AVČR(CZ) M100101212 Institutional support: RVO:68378271 Keywords : scintillator * tunneling * traps Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.209, year: 2015

  13. Role of Wind Tunnels in Aircraft Design

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 1. Role of Wind Tunnels in Aircraft Design. S P Govinda Raju. General Article Volume 8 Issue 1 January 2003 pp 72-76. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/008/01/0072-0076. Keywords.

  14. Explosion risks and consequences for tunnels

    NARCIS (Netherlands)

    Weerheijm, J.; Berg, A.C. van den

    2014-01-01

    Tunnel accidents with transports of dangerous goods may lead to explosions. Risk assessment for these accidents is complicated because of the low probability and the unknown, but disastrous effects expected. Especially the lack of knowledge on the strength of the explosion and the consequences for

  15. A Historical Evaluation of the U12n Tunnel, Nevada national Security Site, Nye County, Nevada Part 2 of 2

    Energy Technology Data Exchange (ETDEWEB)

    Drollinger, Harold [DRI; Jones, Robert C [DRI; Bullard, Thomas F [DRI; Ashbaugh, Laurence J [DRI; Griffin, Wayne R

    2011-06-01

    This report presents a historical evaluation of the U12n Tunnel on the Nevada National Security Site (NNSS) in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency (DTRA). The U12n Tunnel was one of a series of tunnels used for underground nuclear weapons effects tests in Rainier and Aqueduct Mesas. A total of 22 nuclear tests were conducted in the U12n Tunnel from 1967 to 1992. These tests include Midi Mist, Hudson Seal, Diana Mist, Misty North, Husky Ace, Ming Blade, Hybla Fair, Mighty Epic, Diablo Hawk, Miners Iron, Huron Landing, Diamond Ace, Mini Jade, Tomme/Midnight Zephyr, Misty Rain, Mill Yard, Diamond Beech, Middle Note, Misty Echo, Mineral Quarry, Randsburg, and Hunters Trophy. DTRA sponsored all tests except Tomme and Randsburg which were sponsored by the Lawrence Livermore National Laboratory. Midnight Zephyr, sponsored by DTRA, was an add on experiment to the Tomme test. Eleven high explosive tests were also conducted in the tunnel and included a Stemming Plan Test, the Pre-Mill Yard test, the two seismic Non-Proliferation Experiment tests, and seven Dipole Hail tests. The U12n Tunnel complex is composed of the portal and mesa areas, encompassing a total area of approximately 600 acres (240 hectares). Major modifications to the landscape have resulted from four principal activities. These are road construction and maintenance, mining activities related to development of the tunnel complex, site preparation for activities related to testing, and construction of retention ponds. A total of 202 cultural features were recorded for the portal and mesa areas. At the portal area, features relate to the mining, construction, testing, and general everyday operational support activities within the tunnel. These include concrete foundations for buildings, ventilation

  16. A Historical Evaluation of the U12n Tunnel, Nevada National Security Site, Nye County, Nevada Part 1

    Energy Technology Data Exchange (ETDEWEB)

    Drollinger, Harold [DRI; Jones, Robert C [DRI; Bullard, Thomas F [DRI; Ashbaugh, Laurence J [DRI; Griffin, Wayne R [DRI

    2011-06-01

    This report presents a historical evaluation of the U12n Tunnel on the Nevada National Security Site (NNSS) in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency (DTRA). The U12n Tunnel was one of a series of tunnels used for underground nuclear weapons effects tests in Rainier and Aqueduct Mesas. A total of 22 nuclear tests were conducted in the U12n Tunnel from 1967 to 1992. These tests include Midi Mist, Hudson Seal, Diana Mist, Misty North, Husky Ace, Ming Blade, Hybla Fair, Mighty Epic, Diablo Hawk, Miners Iron, Huron Landing, Diamond Ace, Mini Jade, Tomme/Midnight Zephyr, Misty Rain, Mill Yard, Diamond Beech, Middle Note, Misty Echo, Mineral Quarry, Randsburg, and Hunters Trophy. DTRA sponsored all tests except Tomme and Randsburg which were sponsored by the Lawrence Livermore National Laboratory. Midnight Zephyr, sponsored by DTRA, was an add on experiment to the Tomme test. Eleven high explosive tests were also conducted in the tunnel and included a Stemming Plan Test, the Pre-Mill Yard test, the two seismic Non-Proliferation Experiment tests, and seven Dipole Hail tests. The U12n Tunnel complex is composed of the portal and mesa areas, encompassing a total area of approximately 600 acres (240 hectares). Major modifications to the landscape have resulted from four principal activities. These are road construction and maintenance, mining activities related to development of the tunnel complex, site preparation for activities related to testing, and construction of retention ponds. A total of 202 cultural features were recorded for the portal and mesa areas. At the portal area, features relate to the mining, construction, testing, and general everyday operational support activities within the tunnel. These include concrete foundations for buildings, ventilation

  17. Tunneling and transport properties of superconductors

    International Nuclear Information System (INIS)

    Tralshawala, N.

    1993-01-01

    We obtained the electron-phonon spectral function, α 2 F(ω), from our tunneling data on Ba 1-x K x BiO 3 (BKBO) and Nd 2-x Ce x CuO 4-y (NCCO). The analysis is novel in its utilization of tunneling α 2 F(ω) function to estimate the contribution to resistivity from the electron-phonon scattering. We tested this methodology for conventional superconductors Nb, V, and VN. We make a strong case for the phonon-mediated coupling in BKBO. We show that phono-mediated coupling plays a major role in the superconductivity of NCCO. Tunneling data on BKBO exhibit a BCS gap and this ratio 2Δ/k B T c (of about 3.9) corresponds to a moderately coupled superconductor. The tunneling α 2 F(ω) compares well with the phonon density of states obtained from the inelastic neutron scattering data; and the T c calculated from the tunneling α 2 F(ω) matches well with the measured value. We explain the resistivity of BKBO using the tunneling α 2 F(ω). The high-T c (about 27 K), the low λ value (about 1), and the fact that optical phonons contribute heavily to the higher T c suggests that a deeper physical understanding of BKBO is needed to understand the high-T c cuprates. NCCO is a moderate T c cuprate superconductor that also shares the presence of spin density wave instability with other cuprates. But NCCO is electron-doped. The gap region tunneling data is distinctly non-BCS-like, but nevertheless we can obtain α 2 F(ω), which compares well with the phonon density of states and can explain the measured T c . We show that NCCO is also moderately coupled with stronger coupling to the optical phonons. Our analysis allows the identification of a T 2 contribution to the resistivity of NCCO and establishes a connection between variations in the magnitude of this contribution and the plasma frequency ω p

  18. Derivation of the tunnelling exchange time for the model of trap-assisted tunnelling

    International Nuclear Information System (INIS)

    Racko, J.; Ballo, P.; Benko, P.; Harmatha, L.; Grmanova, A.; Breza, J.

    2014-01-01

    We present derivation of the tunnelling exchange times that play the key role in the model of trap assisted tunnelling (TAT) considering the electron and hole exchange processes between the trapping centre lying in the forbidden band of the semiconductor and the conduction band, valence band or a metal. All exchange processes are quantitatively described by respective exchange times. The reciprocal values of these exchange times represent the frequency with which the exchange processes contribute to the probability of occupation of the trap by free charge carriers. The crucial problem in any model of TAT is the calculation of the occupation probability. In our approach this probability is expressed in terms of only thermal and tunnelling exchange times. The concept of tunnelling exchange times presents a dominant contribution to our model of TAT. The new approach allows to simply calculate the probability of occupation of the trapping centre by a free charge carrier and subsequently to get the thermal and tunnelling generation-recombination rates occurring in the continuity equations. This is why the TAT model based on thermal and tunnelling exchange times is suitable for simulating the electrical properties of semiconductor nanostructures in which quantum mechanical phenomena play a key role. (authors)

  19. Mechanism of membranous tunnelling nanotube formation in viral genome delivery.

    Directory of Open Access Journals (Sweden)

    Bibiana Peralta

    2013-09-01

    Full Text Available In internal membrane-containing viruses, a lipid vesicle enclosed by the icosahedral capsid protects the genome. It has been postulated that this internal membrane is the genome delivery device of the virus. Viruses built with this architectural principle infect hosts in all three domains of cellular life. Here, using a combination of electron microscopy techniques, we investigate bacteriophage PRD1, the best understood model for such viruses, to unveil the mechanism behind the genome translocation across the cell envelope. To deliver its double-stranded DNA, the icosahedral protein-rich virus membrane transforms into a tubular structure protruding from one of the 12 vertices of the capsid. We suggest that this viral nanotube exits from the same vertex used for DNA packaging, which is biochemically distinct from the other 11. The tube crosses the capsid through an aperture corresponding to the loss of the peripentonal P3 major capsid protein trimers, penton protein P31 and membrane protein P16. The remodeling of the internal viral membrane is nucleated by changes in osmolarity and loss of capsid-membrane interactions as consequence of the de-capping of the vertices. This engages the polymerization of the tail tube, which is structured by membrane-associated proteins. We have observed that the proteo-lipidic tube in vivo can pierce the gram-negative bacterial cell envelope allowing the viral genome to be shuttled to the host cell. The internal diameter of the tube allows one double-stranded DNA chain to be translocated. We conclude that the assembly principles of the viral tunneling nanotube take advantage of proteo-lipid interactions that confer to the tail tube elastic, mechanical and functional properties employed also in other protein-membrane systems.

  20. Real-time data reduction capabilities at the Langley 7 by 10 foot high speed tunnel

    Science.gov (United States)

    Fox, C. H., Jr.

    1980-01-01

    The 7 by 10 foot high speed tunnel performs a wide range of tests employing a variety of model installation methods. To support the reduction of static data from this facility, a generalized wind tunnel data reduction program had been developed for use on the Langley central computer complex. The capabilities of a version of this generalized program adapted for real time use on a dedicated on-site computer are discussed. The input specifications, instructions for the console operator, and full descriptions of the algorithms are included.