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Sample records for tuittila jukka alm

  1. Linnamaastike kaitse on osa arengust / Jukka Jokilehto, Mehr Azar Soheil ; intervjueerinud Liisa Pakosta

    Index Scriptorium Estoniae

    Jokilehto, Jukka

    2010-01-01

    Vestlus soome arhitekti, Nova Gorica ülikooli professori, UNESCO ja ICOMOSi konsultandi Jukka Jokilehto ja tema abikaasa, pärslannast arhitekti Mehr Azar Soheiliga. Ka Tallinna vanalinnast maailmapärandi komitees valmivate linnamaastike kaitseks mõeldud soovituste valguses, linna arengust sadama suunas. Eestikeelsena ilmus J. Jokilehto raamat "Arhitektuuri konserveerimise ajalugu" (Tallinn : Eesti Kunstiakadeemia, 2010)

  2. Safety Analysis Report for the KRI-ALM Transport Package

    Energy Technology Data Exchange (ETDEWEB)

    Bang, K. S.; Lee, J. C.; Kim, D. H.; Park, H. Y.; Kim, J. B.; Kim, H. J.; Seo, K. S

    2005-11-15

    Safety evaluation for the KRI-ALM transport package to transport safely I-123, which is produced at Cyclotron in KIRAMS, was carried out. In the safety analyses results for the KRI-ALM transport package, all the maximum stresses as well as the maximum temperature of the surface are lower than their allowable limits. The safety tests were performed by using the test model of the KRI-ALM transport package. Leak Test was performed after drop test, the measured leakage rate was lower than allowable leakage rate. It is revealed that the containment integrity of the KRI-ALM transport package is maintained. Therefore, it shows that the integrity of the KRI-ALM transport package is well maintained.

  3. Appraisal of ALM predictions of turbulent wake features

    Science.gov (United States)

    Rocchio, Benedetto; Cilurzo, Lorenzo; Ciri, Umberto; Salvetti, Maria Vittoria; Leonardi, Stefano

    2017-11-01

    Wind turbine blades create a turbulent wake that may persist far downstream, with significant implications on wind farm design and on its power production. The numerical representation of the real blade geometry would lead to simulations beyond the present computational resources. We focus our attention on the Actuator Line Model (ALM), in which the blade is replaced by a rotating line divided into finite segments with representative aerodynamic coefficients. The total aerodynamic force is projected along the computational axis and, to avoid numerical instabilities, it is distributed among the nearest grid points by using a Gaussian regularization kernel. The standard deviation of this kernel is a fundamental parameter that strongly affects the characteristics of the wake. We compare here the wake features obtained in direct numerical simulations of the flow around 2D bodies (a flat plate and an airfoil) modeled using the Immersed Boundary Method with the results of simulations in which the body is modeled by ALM. In particular, we investigate whether the ALM is able to reproduce the mean velocity field and the turbulent kinetic energy in the wake for the considered bodies at low and high angles of attack and how this depends on the choice of the ALM kernel. S. Leonardi was supported by the National Science Foundation, Grant No. 1243482 (the WINDINSPIRE project).

  4. ON Integrated Chance Constraints in ALM for Pension Funds

    OpenAIRE

    Youssouf A. F. Toukourou; Fran\\c{c}ois Dufresne

    2015-01-01

    We discuss the role of integrated chance constraints (ICC) as quantitative risk constraints in asset and liability management (ALM) for pension funds. We define two types of ICC: the one period integrated chance constraint (OICC) and the multiperiod integrated chance constraint (MICC). As their names suggest, the OICC covers only one period whereas several periods are taken into account with the MICC. A multistage stochastic linear programming model is therefore developed for this purpose and...

  5. [J. Tapio. Suljetut vaunut, eli, Kadonnutta aikaa etsimässä ; Jukka Kostiainen. Kinnises tõllas, ehk, Kadunud aega otsimas ; Tatu Vaaskivi. Maarjamaa] / Hannu Oittinen

    Index Scriptorium Estoniae

    Oittinen, Hannu, 1959-

    2013-01-01

    Arvustus: Tapio, J. Suljetut vaunut, eli, Kadonnutta aikaa etsimässä. Porvoo : J. Kostiainen, 2012 ; Kostiainen, Jukka. Kinnises tõllas, ehk, Kadunud aega otsimas / tõlkinud Ants Paikre. Tartu : Atlex, 2013 ; Vaaskivi, Tatu. Maarjamaa / tõlkinud Ants Paikre. Tallinn : Kultuurileht, 2013. (Loomingu raamatukogu)

  6. Preparation and characterization of PLGA nanospheres encapsulated with Autoclaved Leishmania Major (ALM) and Quillaja Saponin

    International Nuclear Information System (INIS)

    Tafaghodi, M.; Tabasi, S. Abolghasem Sajadi; Kharazizdeh, M.

    2008-01-01

    Several antigens, adjuvants and delivery systems have been evaluated for induction of protective immune responses against leishmaniasis, but have mostly been inefficient. In this study, poly (d,1-lactide-co-glycolide) (PLGA) nanospheres as antigen delivery system and Quillaja saponins (QS) as an immunoadjuvant have been used to increase the immune responses against Autoclaved Lieshmania major (ALM). PLGA nanospheres were prepared using a double emulsion (W/O/W) technique. The internal aqueous phase contained ALM and saponin, while the oily phase contained the solution of PLGA in dichloromethane and the external aqueous phase was polyvinylacohol (PVA) 7.5% (W/V) solution. Particulate characteristics were studied by scanning electron microscope and particle size analyzer. The encapsulation efficiency was determined by Lowry method and the release profile of antigen and saponin from nanospheres was evaluated for one week. Nanospheres were spherical in shape having smooth surfaces. Mean diameters for nanospheres loaded with ALM and ALM+QS were 300+-123 nm and 294+-106 nm respectively. Encapsulation efficiencies for ALM and QS were found 71+-14.8% and 55.8+- 23.1% respectively. Evaluation of the release profiles of ALM and QS from nanospheres in one week showed that 44.8 +-0.8% of ALM and 29.5+- 0.21% of QS had been released from naospheres. In conclusion, the prepared nanospheres with desirable size, encapsulation efficiency, and slow rate of release, had acceptable features for future in vivo studies. (author)

  7. High-precision branching-ratio measurement for the superallowed β+ emitter 26Alm

    Science.gov (United States)

    Finlay, P.; Ball, G. C.; Leslie, J. R.; Svensson, C. E.; Andreoiu, C.; Austin, R. A. E.; Bandyopadhyay, D.; Cross, D. S.; Demand, G.; Djongolov, M.; Ettenauer, S.; Garrett, P. E.; Green, K. L.; Grinyer, G. F.; Hackman, G.; Leach, K. G.; Pearson, C. J.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Triambak, S.; Williams, S. J.

    2012-05-01

    A high-precision branching-ratio measurement for the superallowed β+ emitter 26Alm was performed at the TRIUMF-ISAC radioactive ion beam facility. An upper limit of ⩽12 ppm at 90% confidence level was found for the second forbidden β+ decay of 26Alm to the 21+ state at 1809 keV in 26Mg. An inclusive upper limit of ⩽15 ppm at 90% confidence level was found when considering all possible nonanalog β+/EC decay branches of 26Alm, resulting in a superallowed branching ratio of 100.0000-0.0015+0%.

  8. Sähköisen markkinointiviestinnän kehittäminen pienyritykselle : Case: Kodinkonehuolto ja myynti T:mi Jukka Mäkeläinen

    OpenAIRE

    Kerola, Anna

    2016-01-01

    Tämän opinnäytetyön aiheena on markkinointiviestinnän kehittäminen pienyritykselle. Toimeksiantajana toimii Kodinkonehuolto ja myynti T:mi Jukka Mäkeläinen. Toiveena oli markkinointiviestinnän siirtäminen verkkoon. Markkinointiviestintää on yrityksessä hoidettu ainoastaan lehtimainonnan avulla, joka ei ole enää tuottanut toivottua tulosta. Facebook-sivun käyttöönoton tarkoituksena oli näkyvyyden lisääminen omalla toiminta-alueella, olemassa olevien asiakkaiden aktivoiminen ja uusien asiakkaid...

  9. High-Precision Half-Life Measurement for the Superallowed β+ Emitter Alm26

    Science.gov (United States)

    Finlay, P.; Ettenauer, S.; Ball, G. C.; Leslie, J. R.; Svensson, C. E.; Andreoiu, C.; Austin, R. A. E.; Bandyopadhyay, D.; Cross, D. S.; Demand, G.; Djongolov, M.; Garrett, P. E.; Green, K. L.; Grinyer, G. F.; Hackman, G.; Leach, K. G.; Pearson, C. J.; Phillips, A. A.; Sumithrarachchi, C. S.; Triambak, S.; Williams, S. J.

    2011-01-01

    A high-precision half-life measurement for the superallowed β+ emitter Alm26 was performed at the TRIUMF-ISAC radioactive ion beam facility yielding T1/2=6346.54±0.46stat±0.60systms, consistent with, but 2.5 times more precise than, the previous world average. The Alm26 half-life and ft value, 3037.53(61) s, are now the most precisely determined for any superallowed β decay. Combined with recent theoretical corrections for isospin-symmetry-breaking and radiative effects, the corrected Ft value for Alm26, 3073.0(12) s, sets a new benchmark for the high-precision superallowed Fermi β-decay studies used to test the conserved vector current hypothesis and determine the Vud element of the Cabibbo-Kobayashi-Maskawa quark mixing matrix.

  10. Integración de un Modelo S&OP con un Modelo ALM

    OpenAIRE

    Insuasty Chamorro, Andrés Felipe

    2015-01-01

    DecisionWare International Corp. (DW) Este trabajo presenta los fundamentos metodológicos y la aplicación de la integración de un modelo financiero ALM (Assets Liabilities Management) con los modelos de planificación de la cadena de oferta de una empresa industrial global como son el SCD (Supply Chain Design) y el S&OP (Sales & Operation Planning). La aplicación en este trabajo se concentra en el modelo S&OP vinculado a un modelo ALM. Como resultado práctico se presenta la implementación d...

  11. Atypical Alstrom syndrome with novel ALMS1 mutations precluded by current diagnostic criteria.

    LENUS (Irish Health Repository)

    Casey, Jillian

    2014-02-01

    We report on clinical and genetic studies in a non-consanguineous Irish sib-pair with infantile dilated cardiomyopathy and retinopathy. A diagnosis of Alström Syndrome (AS) was considered and diagnostic testing pursued. The Alströms gene (ALMS1) is very large (23 exons) and diagnostic testing of mutational hotspots (exon 6, 8 and 10) was negative. Furthermore the siblings were tall and did not have the typical phenotype of nystagmus, photophobia, obesity or hearing loss and so the AS diagnosis was removed. We then sought to identify the causative gene in this family using whole exome sequencing. Unexpectedly, the exome analysis identified novel compound heterozygous ALMS1 mutations in exon 5 (c.777delT:p.D260fs*26) and exon 20 (c.12145_12146insC:p.S4049fs*36) that segregated with the phenotype. Although the siblings show some clinical overlap with AS, their phenotype is not classical. It is plausible that their atypical presentation may be due to the location of the ALMS1 mutations outside the usual mutational hotspots. Our findings show how atypical cases of AS may be missed under the current diagnostic guidelines and support consideration of complete ALMS1 sequencing in children with two or more features, even if all of the core clinical features of AS are not present.

  12. Recombination Narratives to Accompany "A-LM French One," First Edition.

    Science.gov (United States)

    Coughlin, Dorothy

    Supplementary recombination narratives intended for use with the 1961 edition of the text "A-LM French One" are designed to help students learn to manipulate basic textual materials. The sample narratives correlate with Units 4-14 of the text. The teacher is urged to make use of the overhead projector when using the narratives for the…

  13. The Generation of AlmFe in Dilute Aluminium Alloys with Different Grain Refining Additions

    Science.gov (United States)

    Meredith, M. W.; Greer, A. L.; Evans, P. V.; Hamerton, R. G.

    Al13Fe4, Al6Fe and AlmFe are common intermetallics in commercial AA1XXX series Al alloys. Grain-refining additions (based on either Al-Ti-B or Al-Ti-C) are usually added to such alloys during solidification processing to aid the grain structure development. They also influence the favoured intermetallic and, hence, can affect the materials' properties. This work simulates commercial casting practices in an attempt to determine the mechanisms by which one intermetallic phase is favoured over another by the introduction of grain-refining additions. Directional solidification experiments on Al-0.3wt.%Fe-0.15wt.%Si with and without grain refiner are conducted using Bridgman apparatus. The type, amount and effectiveness of the grain-refining additions are altered and the resulting intermetallic phase selection followed. The materials are characterised using optical microscopy, scanning electron microscopy and X-ray diffraction. AlmFe is seen to form when Al-Ti-B grain-refiner is introduced but only when the refinement is successful; reducing the effectiveness of the refiner led to Al6Fe forming under all conditions. Al-Ti-C refiners are seen to promote AlmFe at lower solidification velocities than when Al-Ti-B was used even though the grain structure was not as refined. These trends can be explained within existing eutectic theory, by considering growth undercooling.

  14. Suverehve valima! / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2012-01-01

    TM võrdleb suverehve. Auto: Audi A3. Rehvimõõt: 205/55R16. Rehvid: Barum Bravuris 2; BF Goodrich g-Grip; Continental ContiPremiumContact 5; Dunlop SP Sport Fastresponse; Goodyear EfficientGrip; Hankook Ventus Prime 2; Jinyu YU63; Michelin Pilot Sport 3; Nokian Hakka Blue ; Pirelli Cinturato P7

  15. Seinast seina / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2014-01-01

    TM võrdleb suverehve. Auto: Ford Focus Rehvimõõt: 205/55 R 16V. Rehvid: Apollo Alnac 4G, Barum Bravuris 3, BF Goodrich g-Grip, Continental ContiPremiumContact 5, Dunlop SP BluResponse, Goodyear EfficientGrip Performance, Hankook Ventus Prime ,2 Hercules Raptis VR1, Landsail LS288, Michelin Primacy 3, Nokian Hakka Blue, Pirelli Cinturato P7, Toyo Proxes CF2, Vredestein Sporttrac 5

  16. Evaluación de sustratos para almácigos de hortalizas

    Directory of Open Access Journals (Sweden)

    Gustavo Quesada Rold\\u00E1n

    2005-01-01

    Full Text Available Se realizó una evaluación agronómica de almácigos de hortalizas (tomate, pepino, lechuga y brócoli establecidos en diferentes sustratos, en la Estación Experimental Fabio BaudritMoreno, Alajuela, Costa Rica, bajo condiciones de invernadero, del 12 de abril al 7 de mayo del 2004. Se utilizaron bandejas plásticas de 128 celdas de forma piramidal invertida. El diseño experimental utilizado fue un irrestricto completamenteal azar con cuatro repeticiones. Ala edad de transplante seevaluaron variables de vigor de germinación, desarrollo deplanta y calidad de adobe. Los sustratos que permitieron elmejor desarrollo de las plantas en los cultivos de brócoli, pepino y tomate fueron abono orgánico Juan Viñas; lombricom-post + abono orgánico Juan Viñas + granza; y abono orgánicoJuan Viñas + granza. Los sustratos aserrín de melina madurado + suelo + granza; y peat moss + perlita fueron los mejoresmedios para almácigos de lechuga. Se observó además en lossustratos abono orgánico Juan Viñas + aserrín de melina ma-durado + granza; bagazo + aserrín de melina madurado + abono orgánico Juan Viñas; y aserrín de melina madurado + fibrade coco + ceniza, una excelente calidad de adobe, aunque undesarrollo de la planta no tan vigoroso. Los sustratos “tierrafermentada”; fibra de coco; sustrato comercial 2; y bagazo +fibra de coco + piedra pómez fueron los que más limitaron elestablecimiento de las plantas de almácigo.

  17. High-Precision Half-Life and Branching Ratio Measurements for the Superallowed β+ Emitter 26Alm

    Science.gov (United States)

    Finlay, P.; Svensson, C. E.; Demand, G. A.; Garrett, P. E.; Green, K. L.; Leach, K. G.; Phillips, A. A.; Rand, E. T.; Ball, G.; Bandyopadhyay, D.; Djongolov, M.; Ettenauer, S.; Hackman, G.; Pearson, C. J.; Leslie, J. R.; Andreoiu, C.; Cross, D.; Austin, R. A. E.; Grinyer, G. F.; Sumithrarachchi, C. S.; Williams, S. J.; Triambak, S.

    2013-03-01

    High-precision half-life and branching-ratio measurements for the superallowed β+ emitter 26Alm were performed at the TRIUMF-ISAC radioactive ion beam facility. An upper limit of ≤ 15 ppm at 90% C.L. was determined for the sum of all possible non-analogue β+/EC decay branches of 26Alm, yielding a superallowed branching ratio of 100.0000+0-0.0015%. A value of T1/2 = 6:34654(76) s was determined for the 26Alm half-life which is consistent with, but 2.5 times more precise than, the previous world average. Combining these results with world-average measurements yields an ft value of 3037.58(60) s, the most precisely determined for any superallowed emitting nucleus to date. This high-precision ft value for 26Alm provides a new benchmark to refine theoretical models of isospin-symmetry-breaking effects in superallowed β decays.

  18. Adenosine, lidocaine and Mg2+ (ALM fluid therapy attenuates systemic inflammation, platelet dysfunction and coagulopathy after non-compressible truncal hemorrhage.

    Directory of Open Access Journals (Sweden)

    Hayley Letson

    Full Text Available Systemic inflammation and coagulopathy are major drivers of injury progression following hemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of hemorrhagic shock.Sprague-Dawley rats (429±4 g were randomly assigned to: 1 shams, 2 no-treatment, 3 saline-controls, 4 ALM-therapy, and 5 Hextend®. Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe. After 15 min, a bolus of 3% NaCl ± ALM (0.7 ml/kg was administered intravenously (Phase 1 followed 60 min later by 4 hour infusion of 0.9% NaCl ± ALM (0.5 ml/kg/hour with 1-hour monitoring (Phase 2. Plasma cytokines were measured on Magpix® and coagulation using Stago/Rotational Thromboelastometry.After Phase 1, saline-controls, no-treatment and Hextend® groups showed significant falls in white and red cells, hemoglobin and hematocrit (up to 30%, whereas ALM animals had similar values to shams (9-15% losses. After Phase 2, these deficits in non-ALM groups were accompanied by profound systemic inflammation. In contrast, after Phase 1 ALM-treated animals had undetectable plasma levels of IL-1α and IL-1β, and IL-2, IL-6 and TNF-α were below baseline, and after Phase 2 they were less or similar to shams. Non-ALM groups (except shams also lost their ability to aggregate platelets, had lower plasma fibrinogen levels, and were hypocoagulable. ALM-treated animals had 50-fold higher ADP-induced platelet aggregation, and 9.3-times higher collagen-induced aggregation compared to saline-controls, and had little or no coagulopathy with significantly higher fibrinogen shifting towards baseline. Hextend® had poor outcomes.Small-volume ALM bolus/drip mounted a frontline defense against non-compressible traumatic hemorrhage by defending immune cell numbers, suppressing systemic inflammation, improving platelet

  19. A study on the detection of misfiring cylinder of the diesel engine in excavation machinery using improved ALM analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nagayama, M.; Kawamura, Y. [Tsukuba Univ., Tsukuba, Ibaraki (Japan); Ujihira, M. [Hokkaido Univ., Sapporo (Japan). School of Engineering; Akhmetov, D.F.; Ito, F.; Aoshima, N. [NTT DoCoMo Inc. (Japan)

    2005-07-01

    Mechanical problems in large-scale mining equipment can result in serious losses in operational efficiency and profits. A misfiring cylinder in a diesel engine can cause engine failure in a short period of time. Regular maintenance and inspection of machinery is therefore critical for mining and construction operations. For that reason, an innovative method was developed to detect whether a cylinder is misfiring, and if so, which one. This study established a simple, reliable and sure method using the improved aggregative learning method (ALM) analysis for the early diagnosis and repair of misfiring cylinders. A minimum number of sensors were applied on the side of 2 cylinders on a diesel engine in order to set up an abnormal diagnostic system that detects anomalies at an early stage by analyzing the acceleration waveform using the ALM method. The detection method is better than traditional methods that require accelerometers. 6 refs., 1 tab., 5 figs.

  20. Representing Northern Peatland Hydrology and Biogeochemistry with ALM Land Surface Model

    Science.gov (United States)

    Shi, X.; Ricciuto, D. M.; Thornton, P. E.; Hanson, P. J.; Xu, X.; Mao, J.; Warren, J.; Yuan, F.; Norby, R. J.; Sebestyen, S.; Griffiths, N.; Weston, D. J.; Walker, A.

    2017-12-01

    Northern peatlands are likely to be important in future carbon cycle-climate feedbacks due to their large carbon pool and vulnerability to hydrological change. Predictive understanding of northern peatland hydrology is a necessary precursor to understanding the fate of massive carbon stores in these systems under the influence of present and future climate change. Current models have begun to address microtopographic controls on peatland hydrology, but none have included a prognostic calculation of peatland water table depth for a vegetated wetland, independent of prescribed regional water tables. Firstly, we introduce a new configuration of the land model (ALM) of Accelerated Climate model for Energy (ACME), which includes a fully prognostic water table calculation for a vegetated peatland. Secondly, we couple our new hydrology treatment with vertically structured soil organic matter pool, and the addition of components from methane biogeochemistry. Thirdly, we introduce a new PFT for mosses and implement the water content dynamics and physiology of mosses. We inform and test our model based on SPRUCE experiment to get the reasonable results for the seasonal dynamics water table depths, water content dynamics and physiology of mosses, and correct soil carbon profiles. Then, we use our new model structure to test the how the water table depth and CH4 emission will respond to elevated CO2 and different warming scenarios.

  1. The economy of charity and forgiveness. Alms and indulgences in late medieval Lombardy

    Directory of Open Access Journals (Sweden)

    Giuliana Albini

    2016-05-01

    Full Text Available In the late Middle Ages, one of the ways to support hospitals and confraternities was the collection of alms, associated with the granting of indulgences. Through confession, the believers acquired the forgiveness from sins, and through acts of devotion and charity the reduction of the punishment to expiate in the afterlife (in Purgatory. Although studies on the topic are scarce, it is not risked to say that the indulgences had a particular luck in charities. The following pages are designed to provide new elements about the ways in which, in Lombardy, hospitals and confraternities guaranteed themselves privileges for indulgences given by the Pope and by the bishops. A special effort has been made to quantify (whenever the sources allowed to do it the costs that the institution had to incur for the management of a campaign of indulgences and the economic benefits derived from it. If in certain hospital orders the economic impact of collecting money seems to be relevant, in other cases it appears marginal. This latter is the case of the Great Hospital in Milan, which does not seem to depend on the collection of money linked to indulgences. But, despite this reduced economic impact, the Hospital reserved an important role on the "festa del Perdono" (indulgence granted by Pope Pius II, because, in the context of charity and assistance, the symbolic and communicative value was important like the material aid to the poors.

  2. Impact of the ALMS and MAINTAIN trials on the management of lupus nephritis.

    Science.gov (United States)

    Morris, Heather K; Canetta, Pietro A; Appel, Gerald B

    2013-06-01

    Current treatment of lupus nephritis consists of both induction and maintenance therapy, with the latter being designed to consolidate remissions and prevent relapses. Long-term maintenance treatment with intravenous cyclophosphamide was effective but associated with considerable toxicity. A small but well-designed controlled trial found that for post-induction maintenance therapy, both oral mycophenolate mofetil (MMF) and oral azathioprine were superior in efficacy and had reduced toxicity than a regimen of continued every third month intravenous cyclophosphamide. Although these oral agents were rapidly accepted and utilized as maintenance medications, their usage was based on scant evidence and there were no comparisons between the two. Recently, two relatively large, randomized, well-controlled, multicenter trials dealing with maintenance therapy for severe lupus nephritis have been completed. The Aspreva Lupus Management Study (ALMS) maintenance and MAINTAIN nephritis trials provide important information regarding the comparative efficacy and safety of MMF and azathioprine as maintenance therapies, as well as information on the effect of dosage and duration of treatment with these agents.

  3. Ultra-High Precision Half-Life Measurement for the Superallowed &+circ; Emitter ^26Al^m

    Science.gov (United States)

    Finlay, P.; Demand, G.; Garrett, P. E.; Leach, K. G.; Phillips, A. A.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Grinyer, G. F.; Leslie, J. R.; Andreoiu, C.; Cross, D.; Austin, R. A. E.; Ball, G. C.; Bandyopadhyay, D.; Djongolov, M.; Ettenauer, S.; Hackman, G.; Pearson, C. J.; Williams, S. J.

    2009-10-01

    The calculated nuclear structure dependent correction for ^26Al^m (δC-δNS= 0.305(27)% [1]) is smaller by nearly a factor of two than the other twelve precision superallowed cases, making it an ideal case to pursue a reduction in the experimental errors contributing to the Ft value. An ultra-high precision half-life measurement for the superallowed &+circ; emitter ^26Al^m has been made at the Isotope Separator and Accelerator (ISAC) facility at TRIUMF in Vancouver, Canada. A beam of ˜10^5 ^26Al^m/s was delivered in October 2007 and its decay was observed using a 4π continuous gas flow proportional counter as part of an ongoing experimental program in superallowed Fermi β decay studies. With a statistical precision of ˜0.008%, the present work represents the single most precise measurement of any superallowed half-life to date. [4pt] [1] I.S. Towner and J.C. Hardy, Phys. Rev. C 79, 055502 (2009).

  4. Safety Analysis Report for Packaging (SARP): USA/9507/BLF (ERDA--AL), Model AL-M1

    International Nuclear Information System (INIS)

    Watkins, R.A.; Bertram, R.E.; Blauvelt, R.K.; Edling, D.A.; Flanagan, T.M.; Griffin, J.F.; Rhinehammer, T.B.

    1977-01-01

    The SARP includes structural integrity, thermal resistance, radiation shielding and radiological safety, nuclear criticality safety, and quality control of three insulated drum shipping containers identified as USA/9507/BLF (ERDA-AL), also called AL-M1, configurations 1, 3, and 5. Complete physical and technical descriptions of the packages are presented. Each package consists of an inner container centered within an insulated steel drum. The contents are plutonium-239 and uranium-235 in configurations-1 and -3. The configuration-5 package is intended for shipment of up to 100,000 Ci of tritiated water immobilized on a sorbent such as molecular sieve

  5. La titrisation à l'heure de l'EURO : une opportunité de gestion ALM performante.

    OpenAIRE

    Corinne Jaffeux

    1997-01-01

    L'unification des marchés financiers pour les six pays in va entraîner une réallocation des bilans des établissements de crédit, et une nouvelle gestion des actifs-passifs. La titrisation, technique récente, importée des Etats-Unis et légiférée en France par la loi de 1998 présente un certain nombre d'avantages pour les gestionnaires en charge de la gestion ALM de leurs établissements. Après avoir traité des conséquences que l'on perçoit au passage à l'Euro le 1er janvier 1999, la technique d...

  6. Alms of the Sea” at Teleng Ria Beach Pacitan: Alternative Literacy Ethnoscience for Junior High School

    Science.gov (United States)

    Novitasari, Linda; Astya Agustina, Puput; Sukesti, Ria; Faizal Nazri, Muhammad; Handhika, Jeffry

    2017-11-01

    The purpose of this research is to explore the potential of ethnoscience and the value of local wisdom contained in the tradition of “sea alms” in Teleng Ria Pacitan Beach, to profile as a science literacy in junior high school. The qualitative descriptive method used, where the researcher conducts the study on group culture under natural conditions through observation, interview, and documentation. The profile obtained in a booklet and socialized in students of Junior High School (SMPN 3 Tegalombo and SMPN 1 Pacitan). From this activity obtained information that the ability of students in interpreting ethnoscience in the tradition of “alms sea” in scientific science knowledge increases. It can conclude that the ethnoscience profile and the value of local wisdom can be used as an alternative science literacy in junior high school and has the potential to be used as a reference provider of data related traditions “Sea alms” and its integration with scientific knowledge.

  7. Muusika : Brahmsi reekviem Tõnu Kaljustega. Rahvusooperi nõukogus. Võimalus veeta õhtu La Scalas. Rene Eespere uus CD. Jukka Savijoki käis Eestis. Võistlesid pianistid. Jõulukontserdid / Peeter Olesk

    Index Scriptorium Estoniae

    Olesk, Peeter, 1953-

    2001-01-01

    Tõnu Kaljuste juhatab Ljubljana Gallus Hallis Johannes Brahmsi "Saksa reekviemi". EMA kuratooriumi ja rahvusooperi Estonia nõukogu arutasid ühisistungil Eesti ooperikunsti, muusikateatri ja kõrgema muusikalise hariduse probleeme. 7. XII kell 19.00 saab "Klassikaraadiost" kuulata Milano La Scala hooaja avaetenduse otseülekannet. Antese väljaandel ilmus CD Rene Eespere kammerteostega. 29.XI ئ 2.XII viibis Eestis Sibeliuse akadeemia klassikalise kitarri õppejõud Jukka Savijoki. 23. ja 24. XI toimus Tartus kolme keskastme muusikakooli noorte pianistide konkurss. 8.XII toimub EMA kammersaalis suur jõulukontsert, kus esinevad parimad EMA üliõpilased. Kontserdiagentuuri Concerto Grosso sari "Advendiaeg poistekooridega" viib kontserte Eestimaa erinevatesse linnadesse. Plaadi "Kahest üks" esitluskontserdiga, kus tuleb esiettekandele Urmas Sisaski kantaat "Armastusesle", tähistab TTÜ Akadeemiline Naiskoor oma 50. aastapäeva . Eesti Naistelaulu Seltsi korraldusel toimus 2. XII Balti Misjonikeskuses Tallinna naiskooride advendikontsert. 28. XI toimus Estonia talveaias Tarmo Lepiku 55. sünniaastapäevale pühendatud mälestuskontsert. 17.XI toimus Põlva kultuuri ja huvikeskuses VII Lõuna-Eesti meestelaulu päev

  8. ALM-FATES: Using dynamic vegetation and demography to capture changes in forest carbon cycling and competition at the global scale

    Science.gov (United States)

    Holm, J. A.; Knox, R. G.; Koven, C.; Riley, W. J.; Bisht, G.; Fisher, R.; Christoffersen, B. O.; Dietze, M.; Chambers, J. Q.

    2017-12-01

    The inclusion of dynamic vegetation demography in Earth System Models (ESMs) has been identified as a critical step in moving ESMs towards more realistic representations of plant ecology and the processes that govern climatically important fluxes of carbon, energy, and water. Successful application of dynamic vegetation models, and process-based approaches to simulate plant demography, succession, and response to disturbances without climate envelopes at the global scale is a challenging endeavor. We integrated demographic processes using the Functionally-Assembled Terrestrial Ecosystem Simulator (FATES) in the newly developed ACME Land Model (ALM). We then use an ALM-FATES globally gridded simulation for the first time to investigate plant functional type (PFT) distributions and dynamic turnover rates. Initial global simulations successfully include six interacting and competing PFTs (ranging from tropical to boreal, evergreen, deciduous, needleleaf and broadleaf); including more PFTs is planned. Global maps of net primary productivity, leaf area index, and total vegetation biomass by ALM-FATES matched patterns and values when compared to CLM4.5-BGC and MODIS estimates. We also present techniques for PFT parameterization based on the Predictive Ecosystem Analyzer (PEcAn), field based turnover rates, improved PFT groupings based on trait-tradeoffs, and improved representation of multiple canopy positions. Finally, we applied the improved ALM-FATES model at a central Amazon tropical and western U.S. temperate sites and demonstrate improvements in predicted PFT size- and age-structure and regional distribution. Results from the Amazon tropical site investigate the ability and magnitude of a tropical forest to act as a carbon sink by 2100 with a doubling of CO2, while results from the temperate sites investigate the response of forest mortality with increasing droughts.

  9. Torsten Almén (1931-2016): the father of non-ionic iodine contrast media.

    Science.gov (United States)

    Nyman, Ulf; Ekberg, Olle; Aspelin, Peter

    2016-09-01

    The Swedish radiologist Torsten Almén is the first clinical radiologist ever to have made a fundamental contribution to intravascular contrast medium design, the development of non-ionic contrast media. He became emotionally triggered by the patients' severe pain each time he injected the ionic "high-osmolar" contrast media when performing peripheral arteriographies in the early 1960s. One day he got a flash of genius that combined the observation of pain, a pathophysiological theory and how to eliminate it with suitable contrast media chemistry. After self-studies in chemistry he developed the concept of iodine contrast media not dissociating into ions in solution to reduce their osmolality and even reach plasma isotonicity. He offered several pharmaceutical companies his concept of mono- and polymeric non-ionic agents but without response, since it was considered against the chemical laws of that time. Contrast media constructed as salts and dissociating into ions in solution was regarded an absolute necessity to achieve high enough water solubility and concentration for diagnostic purposes. Finally a small Norwegian company, Nyegaard & Co., took up his idea 1968 and together they developed the essentially painless "low-osmolar" monomeric non-ionic metrizamide (Amipaque) released in 1974 and iohexol (Omipaque) in 1982 followed by the "iso-osmolar" dimeric non-ionic iodixanol (Visipaque) released in 1993. This has implied a profound paradigm shift with regard to reduction of both hypertonic and chemotoxic side effects, which have been a prerequisite for the today's widespread use of contrast medium-enhanced CT and advanced endovascular interventional techniques even in fragile patients. © The Foundation Acta Radiologica 2016.

  10. Presencia de Patógenos en Almácigos y Semilla de Chile (Capsicum annuum L.) en Aguascalientes y Zacatecas, México

    OpenAIRE

    Velásquez-Valle, Rodolfo; Amador-Ramírez, Mario Domingo; Medina-Aguilar, María Mercedes; Lara-Victoriano, Faustino

    2007-01-01

    Un muestreo realizado en municipios de Aguascalientes y Zacatecas, México, indicó que el 88.4% de los almácigos tradicionales de chile presentaron daños por secadera temprana (damping-off); el área dañada osciló de 1 a 15%. Los hongos Fusarium spp., Rhizoctonia spp. y Alternaria spp. fueron identificados en la superficie de semilla de diversos tipos de chile, así como en plántulas enfermas del mismo cultivo. La fumigación del suelo y la desinfección de la semilla son llevadas a cabo solamente...

  11. Effect of Freeze-Thaw Cycles on Soil Nitrogen Reactive Transport in a Polygonal Arctic Tundra Ecosystem at Barrow AK Using 3-D Coupled ALM-PFLOTRAN

    Science.gov (United States)

    Yuan, F.; Wang, G.; Painter, S. L.; Tang, G.; Xu, X.; Kumar, J.; Bisht, G.; Hammond, G. E.; Mills, R. T.; Thornton, P. E.; Wullschleger, S. D.

    2017-12-01

    In Arctic tundra ecosystem soil freezing-thawing is one of dominant physical processes through which biogeochemical (e.g., carbon and nitrogen) cycles are tightly coupled. Besides hydraulic transport, freezing-thawing can cause pore water movement and aqueous species gradients, which are additional mechanisms for soil nitrogen (N) reactive-transport in Tundra ecosystem. In this study, we have fully coupled an in-development ESM(i.e., Advanced Climate Model for Energy, ACME)'s Land Model (ALM) aboveground processes with a state-of-the-art massively parallel 3-D subsurface thermal-hydrology and reactive transport code, PFLOTRAN. The resulting coupled ALM-PFLOTRAN model is a Land Surface Model (LSM) capable of resolving 3-D soil thermal-hydrological-biogeochemical cycles. This specific version of PFLOTRAN has incorporated CLM-CN Converging Trophic Cascade (CTC) model and a full and simple but robust soil N cycle. It includes absorption-desorption for soil NH4+ and gas dissolving-degasing process as well. It also implements thermal-hydrology mode codes with three newly-modified freezing-thawing algorithms which can greatly improve computing performance in regarding to numerical stiffness at freezing-point. Here we tested the model in fully 3-D coupled mode at the Next Generation Ecosystem Experiment-Arctic (NGEE-Arctic) field intensive study site at the Barrow Environmental Observatory (BEO), AK. The simulations show that: (1) synchronous coupling of soil thermal-hydrology and biogeochemistry in 3-D can greatly impact ecosystem dynamics across polygonal tundra landscape; and (2) freezing-thawing cycles can add more complexity to the system, resulting in greater mobility of soil N vertically and laterally, depending upon local micro-topography. As a preliminary experiment, the model is also implemented for Pan-Arctic region in 1-D column mode (i.e. no lateral connection), showing significant differences compared to stand-alone ALM. The developed ALM-PFLOTRAN coupling

  12. Evaluación de distintas materias primas para la producción de almácigo de tomate

    OpenAIRE

    Fernando Richmond

    2010-01-01

    Se evaluaron mezclas de materias primas naturales en diferentes proporciones y en el siguiente orden: fibra de coco (Cocos nucifera), aserrín de melina (Gmelina arborea) y abono orgánico Coope Victoria, para utilizarlos como sustrato en la etapa de almácigo de tomate híbrido FBM-17. Se hicieron mezclas entre sí de fibra de coco y aserrín de melina en diferentes proporciones (30%, 40% y 50% de cada material), para un total de 9 tratamientos; el abono orgánico se agregó para completar el 100%. ...

  13. Turvalisus kõigepealt / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2015-01-01

    TM võrdleb suverehve. Testiauto: Volkswagen Golf. Rehvimõõt: 205/55 R 16. Rehvid: Apollo Alnac 4G, Barum Bravuris 3 HM, Continental ContiPremiumContact 5, Dunlop Sport Blu Response, Firestone Firehawk TZ300, Goodride Sport SA-37, Goodyear Efficient Grip Performance, Hankook Ventus Prime 2, Kumho Solus HS51, Landsail LS 588 UHP, Michelin Primacy 3, Nankang Econex NA-1, Nokian Hakka Blue, Pirelli Cinturato P7 Blue, Vredestein Sportrac 5 Giugiaro

  14. Kokkuhoid või turvalisus? / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2011-01-01

    Suverehvide võrdlus: Barum Bravuris 2, BF Goodrich g-Grip, Bridgestone Turanza ER300 Ecopia, Continental ContiPremiumContact 2, Dunlop SP Sport Fastresponse, Goodyear EfficientGrip, Hankook Ventus Prime 2, Linglong Green-Max, Michelin Energy Saver, Nokian Hakka Green, Nokian Hakka V, Pirelli Cinturato P7, Sava intensa hp, Sunny SN3630, Vredestein Sporttrac 3

  15. Sport või sportlikkus? / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2016-01-01

    TM võrdleb 18tollised suverehve: Aptany Sport Macro RA301, Continental ContiSportContact 5, Delinte DH2, Dunlop SportMaxx RT2, Goodyear Eagle F1 Asymmetric 3, Hankook Ventus S1 Evo 2, Jinyu YU63, Maxxis Victra Sport Zero One, Michelin Pilot Sport 3, Nankang Sportnex AS-2+, Nokian Hakka Black, Pirelli Cinturato PZero, Toyo Proxes T1 Sport Plus

  16. Valik Euroopa ja Aasia vahel / Jukka Antila

    Index Scriptorium Estoniae

    Antila, Jukka

    2013-01-01

    TM testib suverehve: Apollo Alnac 4G ; Barum Bravuris 2 ; Bridgestone Turanza T001 ; Continental ContiPremiumContact 5 ; Dunlop Sport BluResponse ; Goodyear Efficient Grip Performance ; Hankook Ventus Prime 2 ; Michelin Primacy 3 Nankang Green/Sport ; Nokian Hakka Blue ; Pirelli Cinturato P7 Toyo Proxes CF2 ; Vredestein Sportrac 5

  17. Estudio del desarrollo radical en almácigo de híbridos f1 de café obtenidos por cultivo de tejidos

    Directory of Open Access Journals (Sweden)

    Fabián Echeverría

    2014-01-01

    Full Text Available Plántulas de Híbridos F1 de café, obte - nidas por embriogénesis somática indirecta, fueron aclimatizadas bajo condiciones de inver - nadero, en 2 tipos de contenedores: bandeja con sustrato convencional y malla biodegradable con turba comprimida (Jiffy®. A los 2 meses, las plántulas fueron transferidas a bolsa con sus - trato convencional y desarrolladas en el vivero. Se evaluó el desarrollo y calidad de la planta 8 meses después de su crecimiento en almácigo. Se encontró 33% de raíces rectas y 65% con morfologías anormales como estrangulamien - tos, serpenteadas y bifurcaciones, las cuales tuvieron respectivamente menores valores en los parámetros de largo, grosor y peso, tanto en el sistema radical como aéreo. En cuanto al tipo de contenedor, se obtuvo mayor crecimiento en las plántulas desarrolladas en Jiffy® con res - pecto a las de bandejas, sin embargo, aquellas que preservaron la envoltura durante la etapa de vivero, tuvieron menor crecimiento y desarrollo, con respecto de aquellas que les fue retirado. Se recomienda retirar la cobertura del Jiffy® previo a la siembra en bolsa, así como mejorar la técnica de inmersión temporal para evitar anormalidades morfológicas en los embriones producidos.

  18. Crecimiento de café (Coffea arabica L. durante la etapa de almácigo en respuesta a la salinidad generada por fertilizantes

    Directory of Open Access Journals (Sweden)

    Siavosh Sadeghian Khalajabadi

    2014-12-01

    Full Text Available La salinidad del suelo puede afectar negativamente el crecimiento de las plantas, e incluso causar su muerte. Esta investigación tuvo como propósito, determinar el efecto de la salinidad generada por fertilizantes en el crecimiento de café Coffea arabica L. durante la etapa de almácigo. Se recolectaron muestras de suelo en dos Estaciones Experimentales (EE de Cenicafé (Naranjal en Caldas y Timbío en Cauca y una finca cafetera (FC en Jamundí (Valle del Cauca. Bajo el diseño completamente aleatorio se evaluó para cada suelo la respuesta de café variedad Caturra a 27 tratamientos (factorial 33, resultantes de tres dosis de calcio-Ca, de magnesio-Mg y de potasio-K (0, 1 y 3 g dm-3 de suelo, empleando como fuentes sulfatos. La conductividad eléctrica (C.E., como indicador de la salinidad, se incrementó en conformidad a las dosis, con valores más altos para el Mg, seguido por K y Ca, resultado que se relacionó principalmente con el índice de salinidad de los fertilizantes y su solubilidad. Las diferencias de la C.E. entre las localidades (EE Naranjal>EE Timbío>FC Jamundí se atribuyeron a la capacidad de éstos para retener la humedad. Conforme al aumento de la salinidad disminuyó el peso de las plantas, hasta causar síntomas de toxicidad y posterior muerte. El nivel crítico de la C.E., calculado para el 90% del crecimiento relativo, correspondió en promedio a 1,1 dS m-1.

  19. Structure of AlmFe

    International Nuclear Information System (INIS)

    Skjerpe, P.

    1988-01-01

    The metastable phase Al m Fe (m=4.9-4.4, bodycentred tetragonal, a=8.84, c=21.6 A) has been examined by transmission electron microscopy and high-resolution electron microscopy (HREM). Crystals, 1-10 μm in size, were extracted from a cast Al-0.25 wt%Fe-0.13wt%Si alloy of commercial purity. By the use of electron diffraction patterns, a possible structure model for Al m Fe was set up, assuming space group I4/mmm. The model was in qualitative agreement with diffraction patterns as well as HREM micrographs, recorded in and . Streaks along hhO in the diffraction patterns were ascribed to faults on (110). (orig.)

  20. Evaluación de distintas materias primas para la producción de almácigo de tomate

    Directory of Open Access Journals (Sweden)

    Fernando Richmond

    2010-01-01

    Full Text Available Se evaluaron mezclas de materias primas naturales en diferentes proporciones y en el siguiente orden: fibra de coco (Cocos nucifera, aserrín de melina (Gmelina arborea y abono orgánico Coope Victoria, para utilizarlos como sustrato en la etapa de almácigo de tomate híbrido FBM-17. Se hicieron mezclas entre sí de fibra de coco y aserrín de melina en diferentes proporciones (30%, 40% y 50% de cada material, para un total de 9 tratamientos; el abono orgánico se agregó para completar el 100%. Se evaluó la variable porcentaje de germinación 7 días después de la siembra (dds y porcentaje de plantas trasplantables a 27 dds en cada parcela útil. Además, en 10 plántulas escogidas al azar dentro de cada parcela útil (a 27 dds se evaluó: altura de plántula, grosor del tallo, peso seco de raíz y parte aérea, relación raíz/parte aérea y calidad de adobe. Del total de tratamientos, los mayores valores para las variables evaluadas se obtuvieron en los 3 tratamientos donde la proporción de aserrín de melina fue 30%, junto con el tratamiento de 40% de fibra de coco + 40% de aserrín de melina + 20% de abono orgánico Coope Victoria; entre ellos el sustrato con tendencia a dar mejores resultados en todas las variables fue la mezcla 30-30-40. Los valores inferiores para las variables evaluadas se obtuvieron en el tratamiento donde no se incluyó en la mezcla abono orgánico (50-50-0, excepto para las variables porcentaje de germinación y relación raíz/parte aérea. La inclusión de abono orgánico en la mezcla del sustrato favoreció la obtención de valores satisfactorios.

  1. The Representation of the Australian Aborigines in Text and Picture: Dr. Med. Pál Almási Balogh (1794-1863 and the Birth of the Science of Anthropology in Central Europe/Hungary

    Directory of Open Access Journals (Sweden)

    Ildiko Sz. Kristof

    2014-11-01

    Full Text Available The article discusses a manuscript entitled Az ember Australiában (The Man in Australia found in one of the collections of private files in the University Library of Eötvös Loránd University, Budapest. Preserved in the miscellaneous files of Pál Almási Balogh, a Hungarian physician active mostly during the first half of the 19th century, and written in Hungarian, this writing describes the bodily structure, the way of life and the geographical environment of the Australian aborigines. Written probably around 1835 and divided into chapters like “Religion”, “Habitation”, “Way of life”, “Marriage”, “Superstition”, “Inclinations”, “Dress”, and “Language,” the manuscript seems however never to have been published. The author identifies this writing of Almási Balogh as the first scientific, ethnographical/anthropological monograph ever written in Hungary on the native inhabitants of the fifth continent, and she analyzes its content according to both its textual-philological and visual-figural register. According to her results, the manuscript was compiled from the works of Jules Dumont d’Urville (1790-1842, David Collins (1756-1810, George Barrington (1755-1804, Alan Cunningham (1791-1839, James Cook (1728-1779, and perhaps some other Western European explorers and natural historians of Australia. And, as for its visual register, it relied heavily on the illustrations of Voyage pittoresque autour du monde of Dumont d’Urville, published in different languages in Western Europe from 1834-1835 on.

  2. Tüketim Dinamikleri Ölçeği: Kurumsal Din Eğitimi Almış Bireylerde Tüketim Eğilimleri

    Directory of Open Access Journals (Sweden)

    Abdullah İnce

    2018-06-01

    tespit etmek ve ne yönde değiştiğini ortaya çıkarmak amacıyla “Tüketim Dinamikleri Ölçeği” (TDÖ geliştirilmiştir. Ölçekler araştırmacıların, bireylerin herhangi bir konu hakkında ne hissettiğini ya da düşündüğünü ölçmeyi hedeflediği durumlarda sıklıkla kullanılır. Sosyal bilimlerde yer alan farklı ölçekler mevcuttur. Thurstone, Likert, Guttman ve Bogardus’un ölçekleri yaygın olarak kullanılan ölçekler arasındadır. Bu çalışmada amaç ve kapsam doğrultusunda Likert tipi ölçek hazırlanmıştır. Çalışmada birinci pilot uygulama sürecinde 5’li Likert tipi ölçek, ikinci pilot uygulama ve veri toplama sürecinde 10’lu Likert tipi ölçek kullanılmıştır. Literatürde bireylerin kurumsal din eğitimi almış tüketim eğilimlerinin altında yatan dinamikleri ortaya çıkarmak için yapılan bir çalışmaya rastlanmamıştır. Çalışmada nicel araştırma yaklaşımı benimsenmiş ve yüz yüze anket tekniğiyle veriler toplanmıştır. Ölçek geliştirme çalışması 2016 yılı Ağustos ayından başlayarak yaklaşık altı aylık bir süre almıştır. Bu kapsamda %3 hata payı ile 516 kişiye ulaşılması yeterlidir ancak 600 kişiye anket uygulanmış, geçersiz anketler araştırma dışında bırakılarak örneklem sayısı 563 olmuştur. Örnekleme dâhil olan bireyler kota örnekleme ile seçilmiştir. Bu çalışmada literatür taraması, uzman görüşüne başvurma, akademisyenlerle yapılan beyin fırtınası ve gözlemlerimiz sonucunda bir ifade havuzu oluşturulmuştur. İlk aşamada 93 maddelik soru havuzu değerlendirme sonrasında 49 maddeye indirilmiş, daha sonra bazı sorular birleştirilmiş ve yakın anlama gelen sorular çıkarılarak soru formu 30 madde ile pilot uygulamaya hazır hale getirilmiştir. Çalışmada iki pilot uygulama gerçekleştirilmesi uygun görülmüştür. Birinci pilot uygulama kapsamında 47 kişiye ulaşılmış ve 30 soruluk 5’li Likert tipi anket

  3. Pedir, dar y recibir: las limosnas a los pobres en La de Misericordia de Braga (siglos XVII-XVIII = Begging, Giving and Receiving: Alms to the Poor in the Misericordia of Braga (XVII-XVIII Centuries

    Directory of Open Access Journals (Sweden)

    Maria Marta Lobo de Araújo

    2016-11-01

    Full Text Available ResumenEn este artículo se estudia el proceso de distribución de las limosnas en la Misericordia de Braga durante la Edad Moderna, desde la petición, la entrega o la recepción. Asistir a los pobres era el objetivo primordial de estas cofradías, pero cada una desarrollaba estrategias propias, de acuerdo con los ingresos con los que contaba. Las limosnas distribuidas a los pobres por la Santa Casa de Braga variaron en el tiempo, debido sobre todo a las opciones de gestión  de los miembros de la Mesa, pero crecieron durante la Edad Moderna. Muy valorada en términos espirituales, la limosna servía para que los ricos alcanzasen más fácilmente la salvación. Se trataba, por tanto, de un arma muy poderosa en términos terrenales porque representaba el prestigio y el poder, pero también en términos espirituales ya que se esperaba que contribuyese a que sus autores alcanzasen la gloria eterna. Su distribución, no era automática, es decir, no bastaba con ser pobre y pedir, el receptor tenía que ser merecedor de la misma, y por ello encajar en los criterios marcados por la institución distribuidora.AbstractWe study the alms distribution process in the Misericórdia of Braga during the Modern Age, from the request to give and take. Assist the poor was the target of these brotherhoods, but each developed their own strategies, in accordance with the recipes she had. Alms distributed to the poor by the Santa Casa of Braga known oscillations in time, mainly due to management options of the board members, but they were growing in the Modern Age.Highly valued in spiritual terms, almsgiving served for rich more easily reached salvation. It was therefore a very powerful weapon in earthly terms, because capitalized prestige and power, but also in spiritual terms, since their authors expected from them to contribute to obtain eternal glory. But it was not automatic, that is not enough to be poor and begging, had to be worthy and fit the criteria used

  4. Kunstnik Julian Schnabel vallutab Soome kahel rindel / Jukka Kiho

    Index Scriptorium Estoniae

    Kiho, Jukka

    2008-01-01

    Tamperes esilinastub kunstniku film "Lou Reed's Berlin", mis valmis Ameerikas 2006. a. ja kus laulja Lou Reed mängib esimest korda tervikuna ära 1973. aastal ilmunud plaadi. Kiasmas Helsingis avatakse kunstniku maalinäitus "Noorte kartlike nunnade pühendunud vaade"

  5. Optimal dividends and ALM under unhedgeable risk

    NARCIS (Netherlands)

    Pelsser, A.A.J.; Laeven, R.J.A.

    2013-01-01

    In this paper we develop a framework for optimal investment decisions for insurance companies in the presence of (partially) unhedgeable risk. The perspective that we choose is from an insurance company that maximises the stream of dividends paid to its shareholders. The policy instruments that the

  6. Critical control points for meat balls and kibbe preparations in a hospital kitchen Pontos críticos de controle na preparação de almôndegas e kibes em uma cozinha hospitalar

    Directory of Open Access Journals (Sweden)

    Débora Midori Myaki Pedroso

    1999-12-01

    Full Text Available Hazards and critical control points (CCP associated with meat balls and kibbe preparations in a hospital kitchen were determined using flow diagrams and microbiological testing of samples collected along the production line. Microbiological testing included counts of mesophilic and psicrothrophic microorganisms, yeasts and molds, total and fecal coliforms, C. perfringens, coagulase positive staphylococci, bacteria of the B. cereus group and detection of Salmonella. Time/temperature binomial was measured in all steps of preparation. A decision tree was used to help in the determination of CCPs. The detected hazards were: contamination of raw meat and vegetables, multiplication of the microorganisms during meat manipulation, poor hygiene of utensils and equipment, and survival of microorganisms to the cooking process. Cooking and hot-holding were considered CCPs. The results stress the importance of the implementation of a training program for nutricionists and foodhandlers and the monitoring of CCPs and other measures to prevent foodborne diseases.Foram determinados os perigos e os pontos críticos de controle (PCC associados a preparações de almôndegas e kibes em uma cozinha hospitalar, baseados em fluxogramas de preparo e análises microbiológicas de amostras coletadas ao longo da preparação. As análises microbiológicas incluíram a contagem de microrganismos mesófilos, psicrotróficos, bolores e leveduras, C. perfringens, estafilococos coagulase positiva, bactérias do grupo B. cereus, número mais provável de coliformes totais e fecais e pesquisa de Salmonella. Foram medidos o tempo e a temperatura em todas as etapas da preparação. Para a determinação dos PCCs foi utilizada uma árvore decisória. Foram detectados os seguintes perigos: a contaminação da carne e vegetais crus, a multiplicação dos microrganismos durante a etapa de manipulação da carne, a falta de higiene dos utensílios equipamentos, a sobrevivência de

  7. Identificación de la cantidad y frecuencia óptimas de riego para almácigos de café (Coffea arabica v. “castillo” en la subestación experimental de Cenicafé Santander

    Directory of Open Access Journals (Sweden)

    Fánor Casierra-Posada

    2011-11-01

    Full Text Available La mala distribución del régimen de lluvias causa un déficit hídrico que se hace una limitante en el desarrollo de plantas de café en  la  fase de almácigo. Este  déficit  interviene  con  el  crecimiento, desarrollo  y distribución  de  la  biomasa de  las plántulas.  Se  realizó un  ensayo  con  el  fin  de identificar  la  cantidad  y  frecuencia  de  riego adecuadas para obtener almácigos de excelentescondiciones para café de la variedad Castillo, en la  subestación  experimental de Cenicafé en  el municipio de Floridablanca  (Santander, Colombia. De  esta manera  se  evaluaron  seis  niveles  de riego: 250; 350; 450; 550; 650 y 750 mm durante 120  días, que  corresponde  a  tres  valores  por encima  y  tres  por  debajo  del  promedio  de precipitación de  la  zona.  Se  utilizaron  cinco frecuencias de riego: cada 3; 6; 9; 12 y 15 días. Sepresentaron diferencias  altamente  significativas entre los tratamientos de distintas cantidades de agua, con un mejor comportamiento para 550 y 650 mm en comparación con el  tratamiento de 250 mm.  Estas  diferencias  se  vieron  en  las variables de altura de la planta, longitud de  la raíz,área foliar, peso fresco total y peso seco total. El peso específico de  las hojas, relación raíz/vástago y materia seca acumulada no mostraron efectos de las distintas cantidades de agua de riego, pero sí hubo variaciones altamente significativas como resultado de las distintas frecuencias de riego.

  8. Ilvese kõne tõstis soomeugrilased uude positsiooni / Jukka Mallinen

    Index Scriptorium Estoniae

    Mallinen, Jukka

    2008-01-01

    Soome PEN-Klubi esimees, soome-vene rahvafoorumi aseesimees analüüsib Eesti presidendi Toomas Hendrik Ilvese kõnet Hantõ-Mansiiskis toimunud soome-ugri kongressil ning Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi vastukõnet. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  9. Rootsi kindral hõivaks sõja korral Eesti saared / Jukka Rislakki

    Index Scriptorium Estoniae

    Rislakki, Jukka

    2011-01-01

    Rootsi sõjateaduste akadeemia väljaandes "Till bröders hjälp. Med sikte på en svensk solidarisk strategi" arutlevad eksperdid, mida Rootsi ja Soome võiksid teha ja peaksid tegema, kui Venemaa ründab Balti riike

  10. "Vaibaparadiisist" saab puhkajate paradiis / Jukka-Pekka Pajunen ; interv. Margit Aedla

    Index Scriptorium Estoniae

    Pajunen, Jukka-Pekka

    2005-01-01

    Kinnisvarafirma Arco Vara ja Soome juhtiv vaba aja sisustaja Holiday Club Finland kavandavad Tallinnasse aastaks 2007 Põhjamaade suurimat spaahotelli. Holiday Club Finlandi projektidirektor spaade turust Eestis, Holiday City Tallinna spaa eripärast ja eelistest võrreldes teiste Eesti spaadega, selle sihtrühmast ning hindadest, Soomes tegutsevatest spaadest. Lisad: Holiday City Tallinn; Taust. Kommenteerib Arco Vara investeerimisdivisjoni projektijuht Jüri Kuusk

  11. Laboratorio virtual de matemáticas (ALME2005)

    OpenAIRE

    Arrieta, Jaime; Canul, Antonio; Martínez, Emir

    2005-01-01

    Concebimos que la modelación de fenómenos es una práctica que está ligada a la construcción de conocimientos matemáticos y en este sentido se han realizado investigaciones entorno a su incorporación al contexto escolar. Sin embargo, el incorporar la experimentación en el aula de matemáticas conlleva dificultades, una de ellas es la carencia de material de laboratorio. El laboratorio virtual es un proyecto que intenta suplir la ausencia de un laboratorio físicamente, sin embargo, esta sustituc...

  12. Charity in a Technological Society: From Alms to Corporation

    Science.gov (United States)

    Foltz, Franz; Foltz, Frederick

    2010-01-01

    Over the past 2,000 years, the concept of charity has moved from the personal care of the poor mandated by religious conviction to a multibillion dollar business. The culture of technological efficiency helped create this transformation. The authors explore the origins of charity and show how technology has drastically altered its form and…

  13. AIPA – Kohti digitaalista lainkäyttöä / Marko Loisa, Jukka-Pekka Sirviö

    Index Scriptorium Estoniae

    Loisa, Marko

    2017-01-01

    Soome justiitsministeeriumi algatatud digitaase infosüsteemi AIPA projektist, mis puudutab prokuröride ja kohtute tööd ja kavatsetakse lõpetada aastaks 2021. Projekt on mõeldud elektrooniliste kohtuprotsesside läbiviimiseks

  14. Real Estate in an ALM Framework - The Case of Fair Value Accounting

    NARCIS (Netherlands)

    D. Brounen (Dirk); M. Porras Prado (Melissa); M.J.C.M. Verbeek (Marno)

    2007-01-01

    textabstractThis study examines the liability hedging characteristic of both direct and indirect real estate, in the advent of fair value accounting obligations for pension funds. We explicitly model pension obligations as being subject to interest and inflation risk to analyze the ability of real

  15. An "Alms-Basket" of "Bric-a-Brac": "Brewer's Dictionary of Phrase and Fable".

    Science.gov (United States)

    Bunge, Charles A.

    1999-01-01

    Describes the development and history of "Brewer's Dictionary of Phrase and Fable," a reference source first published in 1870 that includes the etymology of phrases, allusions and words. Discusses reviews that reflected and shaped its status as a standard reference book, describes the current edition, and considers its enduring value.…

  16. Sündinud vajadusest õhu ja hingamise järele / Jukka Pennanen, Mace Ojala ; soome keelest tõlkinud Triinu Seppam

    Index Scriptorium Estoniae

    Pennanen, Jukka

    2012-01-01

    "Jalgrattasõit raamatukogude eest Balti iikides 2012 ("Cycling for Libraries in the Baltic States 2012") toimus 28. juulist 7. augustini 2012, kus erinevate maade raamatukoguhoidjad ja raamatusõbrad külastasid Eesti, Läti ja Leedu raamatukogusid

  17. Efecto de la poda en el trasplante del almácigo de Pejibaye (bactris gasipaes kunth

    Directory of Open Access Journals (Sweden)

    Carlos Arroyo

    2002-01-01

    Full Text Available Cinco tratamientos con diferentes combinaciones de poda de follaje y raíz en pejibaye se llevaron a cabo, al trasplantarlas al campo con raíz desnuda, y su comportamiento fue evaluado con base en siete variables. Además se evaluaron comparativamente las plántulas que mostraban la hoja emergente u hoja guía contra aquéllas en que ésta aún no era visible externamente. Las plántulas que no sufrieron poda alguna fueron significativamente superiores a todos los tratamientos con alguna forma de poda. Esto, no sólo en porcentaje de sobrevivencia (90,33%, sino también en las otras variables estudiadas y en especial en cuanto a su desarrollo posterior, medido por el peso total de la planta tomado seis meses más tarde. Las plántulas sin follaje y sin raíz, mostraron un porcentaje de sobrevivencia del (66,33%, y su recuperación, medida por peso de raíz y peso aéreo, seis meses más tarde, fue muy inferior a todos los tratamientos. En todos los casos, incluyendo el testigo, la presencia visible de la nueva hoja emergente u hoja guía significó un mayor porcentaje de sobrevivencia. Las siete variables utilizadas resultaron altamente correlacionados, siendo el peso total de la planta quizás el mejor evaluador, pero en el campo, el diámetro del tallo resulta más fácil de manejar en la práctica.

  18. Whole-Exome Sequencing Identifies ALMS1, IQCB1, CNGA3, and MYO7A Mutations in Patients with Leber Congenital Amaurosis

    OpenAIRE

    Wang, Xia; Wang, Hui; Cao, Ming; Li, Zhe; Chen, Xianfeng; Patenia, Claire; Gore, Athurva; Abboud, Emad B.; Al-Rajhi, Ali A.; Lewis, Richard A.; Lupski, James R.; Mardon, Graeme; Zhang, Kun; Muzny, Donna; Gibbs, Richard A.

    2011-01-01

    It has been well documented that mutations in the same retinal disease gene can result in different clinical phenotypes due to difference in the mutant allele and/or genetic background. To evaluate this, a set of consanguineous patient families with Leber congenital amaurosis (LCA) that do not carry mutations in known LCA disease genes was characterized through homozygosity mapping followed by targeted exon/whole-exome sequencing to identify genetic variations. Among these families, a total o...

  19. Morphology, microstructure, and hardness of titanium (Ti-6Al-4V) blocks deposited by wire-feed additive layer manufacturing (ALM)

    International Nuclear Information System (INIS)

    Brandl, Erhard; Schoberth, Achim; Leyens, Christoph

    2012-01-01

    Highlights: ► The microstructure and hardness of deposited Ti-6Al-4V blocks are investigated. ► Hardness is influenced by post heat treatment rather than by process parameters. ► Microstructure within the prior β-grains varies to some extent from grain to grain. ► A 600 °C/4 h treatment significantly increased the average hardness. - Abstract: Additive layer manufacturing offers a potential for time and cost savings, especially for aerospace components made from costly titanium alloys. In this paper, the morphology, microstructure, chemical composition, and hardness of additive manufactured Ti-6Al-4V blocks are investigated and discussed. Blocks (7 beads wide, 7 layers high) were deposited using Ti-6Al-4V wire and a Nd:YAG laser. Two different sets of parameters are used and three different post heat treatment conditions (as-built, 600 °C/4 h, 1200 °C/2 h) are investigated. The experiments reveal elementary properties of additive manufactured Ti-6Al-4V material in correlation to process parameters and heat treatments, which are discussed comprehensively.

  20. Morphology, microstructure, and hardness of titanium (Ti-6Al-4V) blocks deposited by wire-feed additive layer manufacturing (ALM)

    Energy Technology Data Exchange (ETDEWEB)

    Brandl, Erhard, E-mail: erhard.brandl@eads.net [EADS Innovation Works, Metallic Technologies and Surface Engineering, D-81663 Munich (Germany); Schoberth, Achim, E-mail: achim.schoberth@eads.net [EADS Innovation Works, Metallic Technologies and Surface Engineering, D-81663 Munich (Germany); Leyens, Christoph, E-mail: christoph.leyens@tu-dresden.de [Technical University of Dresden, Institute of Materials Science, Chair of Materials Technology, Berndt-Bau, Helmholtzstr. 7, D-01062 Dresden (Germany)

    2012-01-15

    Highlights: Black-Right-Pointing-Pointer The microstructure and hardness of deposited Ti-6Al-4V blocks are investigated. Black-Right-Pointing-Pointer Hardness is influenced by post heat treatment rather than by process parameters. Black-Right-Pointing-Pointer Microstructure within the prior {beta}-grains varies to some extent from grain to grain. Black-Right-Pointing-Pointer A 600 Degree-Sign C/4 h treatment significantly increased the average hardness. - Abstract: Additive layer manufacturing offers a potential for time and cost savings, especially for aerospace components made from costly titanium alloys. In this paper, the morphology, microstructure, chemical composition, and hardness of additive manufactured Ti-6Al-4V blocks are investigated and discussed. Blocks (7 beads wide, 7 layers high) were deposited using Ti-6Al-4V wire and a Nd:YAG laser. Two different sets of parameters are used and three different post heat treatment conditions (as-built, 600 Degree-Sign C/4 h, 1200 Degree-Sign C/2 h) are investigated. The experiments reveal elementary properties of additive manufactured Ti-6Al-4V material in correlation to process parameters and heat treatments, which are discussed comprehensively.

  1. Hanna Geara pastellid Sambas / Kreg¡A-Kristring

    Index Scriptorium Estoniae

    Kreg A-Kristring, pseud., 1962-

    2000-01-01

    Maaliharidusega liibanoni noormehe Hanna Geara, kes õpib Roomas multimeediat, pastellinäitus "Puud sünnivad öösel" galeriis "Sammas". H. Geara piltide võrdlus Edward Hopperi ja Jukka Mäkela maalidega.

  2. Юкка, или новая жизнь / Светлан Семененко

    Index Scriptorium Estoniae

    Семененко, Светлан, 1938-2007

    2013-01-01

    Tekstis on S. Semenenko luuletused. Soome tõlkijast Jukka Mallisest. Ka Soome PEN-klubi kirjandusõhtust 14. nov. 2000, kus esinesid Širali Nurmuradov (Turkmeenia), Vladimir Nekljajev (Valgevene) ja S. Semenenko

  3. Stiilne kahetoaline stuudiokorter / Sanna Vatanen

    Index Scriptorium Estoniae

    Vatanen, Sanna

    2007-01-01

    Infoturvajuhi Markus Porvari renoveeritud korter (71 m2) Helsingi kesklinnas 1925. a. ehitatud majas. Korteris on tipptasemel HI-FI tehnika. Vannitoa, sauna ja tualettruumi kavandas Jukka Airas firmast Airas Design. 7. värv. vaadet

  4. Pop / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2003-01-01

    Heliplaatidest: Dave Gahan "Paper Monsters", Paddy McAloon "I Trawl the Megahertz", Jukka Gustavson Organ Fusion Band "Between Fire And Ice", Tanel Ruben & Victoria "A Sentimental Call", Opiate "Sometimes", The Mooney Suzuki "Electric Sweat"

  5. What is the impact of the publications read by the different Mendeley users? Could they help to identify alternative types of impact? PLoS ALM Workshop, San Francisco

    NARCIS (Netherlands)

    Zahedi Z., Costas R., Wouters, P. F.

    2013-01-01

    The online reference manager tool Mendeley (http://www.mendeley.com/) is one of the most promising tools for altmetrics research (Li, Thelwall and Giustini, 2011;Wouters & Costas, 2012) and it has been already used in other previous studies, for example in Library and Information Science Journals

  6. Tootedisaineri töö peenmehaanika ja olemise jaatus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Tootjate ja riskikapitalistide huvist tootedisaineri teenuse vastu. Eesti disainibüroodest MaDis-Stuudio (Matti Õunapuu), Ten Twelve (asutaja: Jukka Halttunen), Keha3 (Margus Triibmann, Tarmo Luisk, Pavel Sidorenko, juht: Ville Jehe) ja Iseasi (Martin Pärn, Sven Sõrmus, Edina Dufala-Pärn, Pent Talvet, Kaspar Torn), pakutavatest teenustest ja töödest

  7. Hobune kolis Veneetsiasse / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2004-01-01

    Muljeid Veneetsia 9 rahvusvaheliselt arhitektuuribiennaalilt Arsenale hallides. Eestit esindavad sisearhitekt Kristajan Holm, arhitekt Agu Külm ja soome skulptor Jukka-Pekka Jalovaara näituseprojektiga, mis tugineb Madis Jürgeni raamatule "Hää koht" kuivkäimlatest. 7 ill

  8. Mis on hinge hind ehk Imet ei sündinud / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    1999-01-01

    Mängufilm "Ristumine peateega" : režissöör ja produtsent Arko Okk : Stsenarist oma näidendi järgi Jaan Tätte : Operaator Dmitri Jermakov : Kunstnik Pille Jänes : Helilooja Jukka Linkola : Acuba Film 1999. Lisa : Arko Oki elu ja loomingu lühikokkuvõte

  9. Jyväskylä transpordikeskus = Jyväskylä Travel Centre

    Index Scriptorium Estoniae

    2004-01-01

    Jyväskylä transpordikeskuse Hannikaiseni tänaval projekteerisid Arhitektibüroo Harris-Kjisik (kaubajaam, parklahoone) ja Arhitektibüroo Petri Rouhiainen (reisiterminal). Autorid Trevor Harris, Hennu Kjisik, Petri Rouhiainen, Jukka Ollikainen, Kaija Eerikäinen. Asendiplaan, 4 välis- ja 3 sisevaadet

  10. "Külaline" Võrumaal / Ivi Kaarna

    Index Scriptorium Estoniae

    Kaarna, Ivi

    2007-01-01

    Võrumaal jätkusid Suurbritannia-Saksamaa-Soome-Eesti ühisfilmi "Külaline" võtted, režissöör Jukka-Pekka Valkeapää, operaator Tuomo Hutri, produtsent Exitfilmist Anneli Ahven, peaosades Vitali Bobrov, Emilia Ikäheimo, Pavel Liski

  11. Modeling of Aircraft Deicing Fluid Induced Biochemical Oxygen Demand in Subsurface-Flow Constructed Treatment Wetlands

    Science.gov (United States)

    2009-03-01

    Jukka A. Rintala, Christof Holliger, and Alla N. Nozhevnikova. “Evaluation of Kinetic Coefficients Using Intergrated Monod and Haldane Models for...Rousseau, Diederik P. L., Peter A Vanrolleghem, and Niels De Pauw. “Model-Based Design of Horizontal Subsurface Flow constructed Treatment

  12. IBM-i ja Lenovo juhid külastasid Eestit

    Index Scriptorium Estoniae

    2006-01-01

    8.-9. maini 2006. a. viibisid Tallinnas IBM-Lenovo Alliance'i viitsepresident Simon L. Porter ja Lenovo Soome regiooni juhataja Jukka Mäntylä, kes kohtusid kohaliku IT-pressiga ning esitlesid Tallinna Botaanikaaia Palmimaja seminarikeskuses mõlema firma uudiseid

  13. Sõpruslinnad toovad kultuuri / Arja Korhonen

    Index Scriptorium Estoniae

    Korhonen, Arja

    2005-01-01

    Teiste Soome päevade kultuuriürituste seas soome jazzviiuldaja ja laulja Heidi Piirala ja Jukka Lumme kvarteti ning akordionist Kaisa Kujanpää kontserdist Art Cafes 19. mail ja Soome simmanil Virma pubis 20. mail, Kaisa Kujanpää ja laulja Timo Kaitalahti kontserdist Väike-Maarja rahvamajas. Lappeenranna tsirkusekooli Tuikko etendustest

  14. "Jade Warrior" sai Hispaanias kolm preemiat

    Index Scriptorium Estoniae

    2007-01-01

    Eesti osalusega Soome-Hiina kung fu film "Igavese armastuse sõdalane - Jade Warrior" võitis 1. Ibiza ja Formentera filmifestivalil kolm Falco d'Ori auhinda (AJ Annila - parim debüüt-lavastaja, Jukka Uusitalo - filmikunstniku töö eest, Henri Blomberg - operaatritöö eest)

  15. LHC@home takes centre stage : some of the people behind the CPSS and LHC@home programs

    CERN Multimedia

    maximilien Brice

    2005-01-01

    From left to right: Frank Schmidt (AB), Jukka Klem (Helsinki Institute of Physics), Andreas Wagner (IT), Eric McIntosh (IT) and Ben Segal (IT). The program of LHC@home, which aims to use the computing power of PCs when the screen saver is activated, is being relauched as part of the World Year of Physics.

  16. Disainiaasta eelmäng toimus Helsingis / Ave Randviir

    Index Scriptorium Estoniae

    Randviir, Ave, 1981-

    2006-01-01

    Eesti disaini tutvustav rändnäitus "10D" Helsingi disaini infokeskuses Design Forum Finland 23.08-10.09.2006. Osalevad Martin Pärn, Igor Volkov, Heikki Zoova, Tarmo Luisk, Raimo Sau, TEN TWELWE OÜ (Jukka Halttunen, Tommi Silvan), Jan Graps, Lasse Ira, Ivari Männi, Tõnis Vellama, Ilona Gurjanova

  17. López Guzmán, Rafael; Gutiérrez Viñuales, Rodrigo (coords.). Alhambras: arquitectura neoárabe en Latinoamérica. Granada: Almed, 2016, 341 págs. Ilustr. ISBN: 978-84-15063-73-5

    OpenAIRE

    Juan Manuel Barrios Rozúa

    2017-01-01

    Con el libro Alhambras. Arquitectura neoárabe en Latinoamérica el lector se adentrará en el sugestivo mundo de la arquitectura orientalista que, inspirada en cualquier tipo de arquitectura musulmana, podemos encontrar en América. Ciertamente la Alhambra es el modelo más recurrente, pero abundan también los edificios que toman como referentes en mayor o menor medida la arquitectura otomana, egipcia, iraní o mogol, sin olvidar otros edificios de al-Andalus como la mezquita de Córdoba o la Giral...

  18. López Guzmán, Rafael; Gutiérrez Viñuales, Rodrigo (coords.. Alhambras: arquitectura neoárabe en Latinoamérica. Granada: Almed, 2016, 341 págs. Ilustr. ISBN: 978-84-15063-73-5

    Directory of Open Access Journals (Sweden)

    Juan Manuel Barrios Rozúa

    2017-06-01

    Full Text Available Con el libro Alhambras. Arquitectura neoárabe en Latinoamérica el lector se adentrará en el sugestivo mundo de la arquitectura orientalista que, inspirada en cualquier tipo de arquitectura musulmana, podemos encontrar en América. Ciertamente la Alhambra es el modelo más recurrente, pero abundan también los edificios que toman como referentes en mayor o menor medida la arquitectura otomana, egipcia, iraní o mogol, sin olvidar otros edificios de al-Andalus como la mezquita de Córdoba o la Giralda.

  19. Terrorism, pommid ja pangarööv / Anari Koppel

    Index Scriptorium Estoniae

    Koppel, Anari

    2008-01-01

    Töös olevad Eesti mängufilmid - "Kid&Killer" (produtsent Piret Tibbo Hudgins, stsenaristid Mart Kivastik, Katrin Laur ja Hannu Salonen, kes ka filmi lavastab), "Külaline" (soome, saksa eesti, inglise koostööfilm, lavastaja Jukka-Pekka Valkeapää, operaator Tuomo Hutri, produtsent Marit Ahven), "Pangarööv" (režissöör Andrus Tuisk, stsenarist Mihkel Ulman, produtsent Manfred Vainokivi)

  20. 20. X avati arhitektuuri- ja disainigaleriis...

    Index Scriptorium Estoniae

    2004-01-01

    Väljapanek "Vaateaken Eesti ekspositsioonile Veneetsia arhitektuuribiennaalil". Eestit esindab 9. Veneetsia arhitektuuribiennaalil Eesti Arhitektide Liidu projekt "Aeg-maha-arhitektuur", idee autor Kristjan Holm, kaasautorid Liina Jänes ja Pille Epner. Kabli rannast Veneetsiasse teisaldatud puust hobusekujulise välikäimla on loonud Agu Külm ja Jukka-Pekka Jalovaara. Ku-Ku klubis esilinastus Marianne Kõrveri, Rain Tolgi ja Andres Maimiku dokumentaalfilm "Surm Veneetsias"

  1. Eesti arukas hotell St Etienneþi disainibiennaalil

    Index Scriptorium Estoniae

    2008-01-01

    2006. a. käivitus Eesti-Soome koostööprojekt "Estonian and Finnish Design Challenge". Koostöös ettevõtjatega sündis DesignStart programmi piloot "Smart Hotell", milles osalesid disainerid Tarmo Luisk, Ivari Männi, Monika Järg, Keret Altpere, Igor Volkov, Jan Graps, Ken Ruut, Jukka Halttunen, Tapio Anttila ja Ilona Gurjanova ning mis valiti St. Etienneþi disainibiennaali projektide hulka

  2. ILO to promote global asbestos ban.

    Science.gov (United States)

    O'Neill, Rory

    2006-01-01

    The International Labour Office (ILO) is to pursue a global ban on asbestos, the world's biggest ever industrial killer. The landmark decision came with the adoption of a resolution on 14 June 2006 at the ILO conference in Geneva and followed a high level union campaign. Rory O'Neill asked Jukka Takala, director of ILO's Safe Work program, what ILO will now do to help make the world asbestos-free.

  3. Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma.

    Science.gov (United States)

    Zhang, Qing; Ubago, Julianne; Li, Li; Guo, Haiyang; Liu, Yugang; Qiang, Wenan; Kim, J Julie; Kong, Beihua; Wei, Jian-Jun

    2014-10-15

    Uterine smooth muscle tumors (USMTs) constitute a group of histologic, genetic, and clinical heterogeneous tumors that include at least 6 major histologically defined tumor types: leiomyoma (ULM), mitotically active leiomyoma (MALM), cellular leiomyoma (CLM), atypical leiomyoma (ALM), uncertain malignant potential (STUMP), and leiomyosarcoma (LMS). Apart from ULM and LMS, the nature of these variants is not well defined. A total of 167 cases of different USMT variants were collected, reviewed, and diagnostically confirmed based on the World Health Organization and Stanford schemes. These included 38 cases of LMS, 18 cases of STUMP, 42 cases of ALM, 22 cases of CLM, 7 cases of MALM, and 40 cases of ULM. Molecular analysis included selected microRNAs (miRNAs), oncogenes, and tumor suppressors that are highly relevant to USMT. Overall, 49% (17/35) of LMS cases and 7% (1/14) of STUMP cases died due to their USMT, but no deaths were attributed to ALM. miRNA profiling revealed that ALM and LMS shared similar miRNA signatures. P53 mutations and PTEN deletions were significantly higher in LMS, ALM, and STUMP compared with other USMT variants (P 74%) but were significantly less common (< 15%) in CLM, ALM, STUMP, and LMS (P < .01). Six types of USMT have different gene mutation fingerprints. ALM shares many molecular alterations with LMS. Our findings suggest that ALM may be a precursor lesion of LMS or have similar genetic changes during its early stage. © 2014 American Cancer Society.

  4. 75 FR 64785 - Corporate Credit Unions

    Science.gov (United States)

    2010-10-20

    ... management (ALM) and credit risk, and whether to make modifications in the area of corporate governance. NCUA... the revisions, an analysis of how the final investment, credit risk, and asset liability provisions..., credit risk, ALM, liquidity, and capital measures that together should greatly reduce the systemic risk...

  5. Combined pseudo-spectral / actuator line model for wind turbine applications

    DEFF Research Database (Denmark)

    Dag, Kaya Onur

    2017-01-01

    of the developed code is presented and verifications are carried out. In the second part, by using the new LES code, a comprehensive investigation is made for the well-known actuator line model (ALM), which is cost-efficient for investigation of the loading estimations on wind turbine blades. In ALM, the body...

  6. Minnesota agripower project. Quarterly report, October--December 1996

    Energy Technology Data Exchange (ETDEWEB)

    Baloun, J.

    1997-02-01

    Alfalfa leaf meal (AML) is a critical co-product to the economics of the alfalfa biomass energy system. Research is being conducted to characterize the nutritional value of ALM in dairy, beef, and turkey diets and provide an estimate of the economic value al ALM to livestock producers.

  7. Automated contamination monitoring for hot particles

    International Nuclear Information System (INIS)

    Johnstone, G.; Case, L.

    1987-01-01

    INS Corp., the largest nuclear laundry company in the United States, has recently developed two types of automated contamination monitoring systems: 1) the Automated Laundry Monitor (ALM), which provides quality assurance monitoring for protective clothing contamination and 2) a low-level automated monitoring system for Plastic Volume Reduction Service (PVRS). The presentation details the inaccuracies associated with hand-probe frisking which led to the development of the ALM. The ALM was designed for 100% quality assurance monitoring of garments to the most stringent customer requirements. A review of why the ALM is essential in verifying the absence of hot particles on garments is given. The final topic addresses the expansion of the ALM technology in support of the INS Plastic Volume Reduction Service by monitoring decontaminated plastics to free release levels. This presentation reviews the design and operation of both monitoring systems

  8. Density Functional Calculation of the 0.5ML-Terminated Allyl Mercaptan/Si(100)-(2 × 1) Surface

    International Nuclear Information System (INIS)

    Chun-Mei, Tang; Kai-Ming, Deng; Xuan, Chen; Chuan-Yun, Xiao; Yu-Zhen, Liu; Qun-Xiang, Li

    2009-01-01

    The structural and electronic properties of the 0.5 ML-terminated allyl mercaptan (ALM)/Si(100)-(2 × 1) surface are studied using the density functional method. The calculated absorption energy of the ALM molecule on the 0.5 ML-terminated ALM/Si(100)-(2 × 1) surface is 3.36 eV, implying that adsorption is strongly favorable. The electronic structure calculations show that the ALM/Si(100)-(2 × 1), the clean Si(100)-(2 × 1), and the fully-terminated H/Si(100)-(2 × 1) surfaces have the nature of an indirect band gap semiconductor. The highest occupied molecular orbital is dominated by the ALM, confirming the mechanism proposed by Hossain for its chain reaction. (condensed matter: structure, mechanical and thermal properties)

  9. Evaluation of alfalfa leaf meal for dairy cows. Quarterly report, July 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Akayezu, J.M.; Jorgensen, M.A.; Linn, J.G.; Jung, H.J.G. [USDA, St. Paul, MN (United States)

    1997-10-30

    A series of laboratory tests and two feeding experiments were conducted to determine the quality and evaluate the feeding value of alfalfa leaf meal (ALM) for dairy cows. An experiment was also conducted to enhance the protein value of ALM for ruminants. The fiber content of 6 different samples obtained from the processing plant from November 1996 to August 1997 were variable, ranging from 28.8 to 44.5% of DM for NDF, and from 16.0 to 28.6% of DM for ADF. Ash content ranged from 10.1 to 13.8% of the DM. The protein content of ALM was fairly constant and ranged from 21.8 to 23.6% of DM. Amino acids comprise at least 70% of the total CP in ALM, but essential amino acids comprise only about 35% of the total CP. The amino acid profile of ALM is similar to that of alfalfa hay, but markedly different from that of soybean meal. Overall, ALM produced to date is similar in nutrient content to prime alfalfa hay. In one of the feeding trials, ALM pellets were used to replace part of the hay in diets for early lactation cows. The results indicate that ALM pellets can make up as much as 16% of the diet DM in replacement of an equivalent amount of high quality chopped alfalfa hay without adverse effects on production or rumen health. In an other study, ALM replaced soybean meal to supply up to 3 3 % of the total CP in the diet without any detrimental effect on production. However, in each study, dry matter intake was reduced when ALM was included in the diet at or above 15 to 16% of the DM. Although this reduction in feed intake did not influence milk production over the short duration of these studies, it is not known what would happen if ALM was fed over long periods of time. Also, these results should not be interpreted to suggest either that ALM may used to replace all the hay in the diets or that ALM in meal form may be used to replace hay in the diets. Moreover, feed consumption by cows used in these experiments was rather high and somewhat atypical of most cows.

  10. Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.

    Science.gov (United States)

    Vazquez-DeRose, Jacqueline; Schwartz, Michael D; Nguyen, Alexander T; Warrier, Deepti R; Gulati, Srishti; Mathew, Thomas K; Neylan, Thomas C; Kilduff, Thomas S

    2016-03-01

    Hypocretin/orexin (HCRT) neurons provide excitatory input to wake-promoting brain regions including the basal forebrain (BF). The dual HCRT receptor antagonist almorexant (ALM) decreases waking and increases sleep. We hypothesized that HCRT antagonists induce sleep, in part, through disfacilitation of BF neurons; consequently, ALM should have reduced efficacy in BF-lesioned (BFx) animals. To test this hypothesis, rats were given bilateral IgG-192-saporin injections, which predominantly targets cholinergic BF neurons. BFx and intact rats were then given oral ALM, the benzodiazepine agonist zolpidem (ZOL) or vehicle (VEH) at lights-out. ALM was less effective than ZOL at inducing sleep in BFx rats compared to controls. BF adenosine (ADO), γ-amino-butyric acid (GABA), and glutamate levels were then determined via microdialysis from intact, freely behaving rats following oral ALM, ZOL or VEH. ALM increased BF ADO and GABA levels during waking and mixed vigilance states, and preserved sleep-associated increases in GABA under low and high sleep pressure conditions. ALM infusion into the BF also enhanced cortical ADO release, demonstrating that HCRT input is critical for ADO signaling in the BF. In contrast, oral ZOL and BF-infused ZOL had no effect on ADO levels in either BF or cortex. ALM increased BF ADO (an endogenous sleep-promoting substance) and GABA (which is increased during normal sleep), and required an intact BF for maximal efficacy, whereas ZOL blocked sleep-associated BF GABA release, and required no functional contribution from the BF to induce sleep. ALM thus induces sleep by facilitating the neural mechanisms underlying the normal transition to sleep.

  11. Effects of Artichoke (Cynara scolymus L. Leaf Meal and Vitamin E on Productive Performance, Intestinal Microflora and Morphology in Japanese Quail

    Directory of Open Access Journals (Sweden)

    Samadi F

    2015-06-01

    Full Text Available A total of 240, one-day-old quail chicks (Coturnix coturnix japonica were used to study the effects of Artichoke leaf meal (ALM and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not improve growth performance at different rearing periods, whereas dietary vitamin E increased feed intake and body weight gain at day 21 of age (P. The ileal populations of lactobacillus and coliforms was not affected by dietary ALM treatments, whereas vitamin E increased the population of total aerobic bacteria (P≤0.04. The ileal villus height (P≤0.01 and crypt depth (P≤0.008 were reduced in quails fed on diets with ALM and vitamin E. The quails fed diets containing 3 percent ALM and 300 mg/Kg vitamin E had higher villus height:crypt depth ratio. The thickness of muscularies (P≤0.04 and mucosa (P≤0.0007 layers were decreased in birds fed diets containing ALM than control birds. Birds treated with ALM and vitamin E showed a shorter intestinal length (P≤0.02 and a lower pancereas relative weight. The results of this study showed that supplementing diet by ALM (1.5 and 3% and 300 mg/Kg vitamin E did not improve growth performance, ileal microbiota pupolations and intestinal morphometric indices in Japanese quail.

  12. Alamethicin in lipid bilayers: combined use of X-ray scattering and MD simulations.

    Science.gov (United States)

    Pan, Jianjun; Tieleman, D Peter; Nagle, John F; Kucerka, Norbert; Tristram-Nagle, Stephanie

    2009-06-01

    We study fully hydrated bilayers of two di-monounsaturated phospholipids diC18:1PC (DOPC) and diC22:1PC with varying amounts of alamethicin (Alm). We combine the use of X-ray diffuse scattering and molecular dynamics simulations to determine the orientation of alamethicin in model lipids. Comparison of the experimental and simulated form factors shows that Alm helices are inserted transmembrane at high humidity and high concentrations, in agreement with earlier results. The X-ray scattering data and the MD simulations agree that membrane thickness changes very little up to 1/10 Alm/DOPC. In contrast, the X-ray data indicate that the thicker diC22:1PC membrane thins with added Alm, a total decrease in thickness of 4 A at 1/10 Alm/diC22:1PC. The different effect of Alm on the thickness changes of the two bilayers is consistent with Alm having a hydrophobic thickness close to the hydrophobic thickness of 27 A for DOPC; Alm is then mismatched with the 7 A thicker diC22:1PC bilayer. The X-ray data indicate that Alm decreases the bending modulus (K(C)) by a factor of approximately 2 in DOPC and a factor of approximately 10 in diC22:1PC membranes (P/L approximately 1/10). The van der Waals and fluctuational interactions between bilayers are also evaluated through determination of the anisotropic B compressibility modulus.

  13. Effect of Amidated Low Methoxyl Pectin on the Mechanical Properties and Colour Attributes of Fish Mince

    Directory of Open Access Journals (Sweden)

    Rocio M. Uresti

    2003-01-01

    Full Text Available Pectins have been unsuccessfully applied to improve functionality of meat and fish products. Effect of amidated low methoxyl pectin (ALM pectin levels on functionality of Mexican flounder (Cyclopsetta chittendenii mince was studied. Changes in the firmness and work of extrusion of pastes, texture profile analysis (TPA of gels, and colour parameters were determined. ALM pectin at 1 % decreased firmness and work of extrusion of fish pastes but increased hardness, chewiness and cohesiveness of the gels (P<0.05. The addition of ALM pectin increased slightly the whiteness and yellowness of mince gels. Chrome parameter indicated that gels remained in the grayish achromatic region. Therefore ALM pectin at 1 % could be employed to modify the textural properties of fish mince.

  14. Will the new Consumer Protection Act prevent harm to nutritional ...

    African Journals Online (AJOL)

    ... in South Africa can be attributed to aggressive marketing by manufacturers whose claims are not always ... Control Council, which is charged with ensuring the safety, quality and effectiveness of medicines, ... Metrics powered by PLOS ALM.

  15. Plaadid / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2004-01-01

    Uutest plaatidest The Von Bondies "Pawn Shoppe Heart", Papa M "Hole of Burning Alms", Georg Levin "Can't Hold Back", The Coral "Nightfreak And The Sons Of Becker", "In America", Lamb "Between Darkness and Wonder"

  16. 45 CFR 3.44 - Solicitation.

    Science.gov (United States)

    2010-10-01

    ... to display any sign, placard, or other form of advertisement; or to collect private debts; or to solicit business, alms, subscriptions or contributions, except in connection with approved national or...

  17. 2365-IJBCS-Article-Mamoudou Abdoul

    African Journals Online (AJOL)

    hp

    Current prevalence of cattle trypanosomiasis and of its vector in Alme, the infested zone of ... Cattle trypanosomiasis is a disease complex ... production, decrease fertility, increase calf mortality and .... only body condition showed a significant.

  18. Determining Daily Radiation Interception in a Semiarid Inter ...

    African Journals Online (AJOL)

    ... in soil-plant-atmosphere continuum, as net radiation is a major part of the energy balance. ... Africa, where solar radiation is not a limiting factor for plant growth. The results suggested that ... Metrics Loading ... Metrics powered by PLOS ALM

  19. Características fisicoquímicas de nueve híbridos de sorgo (Sorghum bicolor L. Moench y su relación con el contenido de almidón y digestión ruminal

    Directory of Open Access Journals (Sweden)

    Mariana Villarreal-Silva

    2015-01-01

    Full Text Available Nueve híbridos de sorgo (Sorghum bicolor L. Moench se analizaron para determinar la relación de suscaracterísticas físicas [materia seca (MS, peso de mil granos (PMG, tamaño de partícula (TP, densidad relativa(DR, superficie de área (SA, partículas por gramo (PPG, endospermo duro (END-DU, endospermo blando (ENDBL];y químicas [nitrógeno total (NT, fibra detergente ácido (FDA, fibra detergente neutro (FDN, contenidode almidón (ALM, almidón soluble (AlmS, almidón insoluble (AlmNS. La digestión ruminal esperada (DRUMse estimó con las fracciones de AlmS y AlmNS in vitro. El promedio de PMG, TP, DR, SA, PPG y END-DU fuede 24.61 g, 3.17 mm, 1.30 g/cm3, 17.44 cm2/g, 30.33 y 46.68 %, respectivamente El promedio (% de MS, PC,FDN, FDA, ALM, AlmS y AlmNS fue de 92.47, 8.19, 19.17 y 8.30, 69.58, 6.00 y 47.74 respectivamente. Laconcentración de taninos fue baja (0.05 entre las variables físicas o químicas con el contenido total de almidón en el grano;sin embargo las variables densidad relativa y superficie de área, permiten incrementar el poder de predicciónde la digestibilidad ruminal del almidón (DRUM,%= 74.058 - 0.108END-DU + 0.027SA – 5.887DR, R2= 0.77,P<0.05. De acuerdo a los resultados obtenidos, las variedades estudiadas son de dureza intermedia, libres detaninos y con un potencial de digestibilidad ruminal del almidón del 66 %.

  20. Relationship Between Active Learning Methodologies and Community College Students' STEM Course Grades

    Science.gov (United States)

    Clark Lesko, Cherish Christina

    Active learning methodologies (ALM) are associated with student success, but little research on this topic has been pursued at the community college level. At a local community college, students in science, technology, engineering, and math (STEM) courses exhibited lower than average grades. The purpose of this study was to examine whether the use of ALM predicted STEM course grades while controlling for academic discipline, course level, and class size. The theoretical framework was Vygotsky's social constructivism. Descriptive statistics and multinomial logistic regression were performed on data collected through an anonymous survey of 74 instructors of 272 courses during the 2016 fall semester. Results indicated that students were more likely to achieve passing grades when instructors employed in-class, highly structured activities, and writing-based ALM, and were less likely to achieve passing grades when instructors employed project-based or online ALM. The odds ratios indicated strong positive effects (greater likelihoods of receiving As, Bs, or Cs in comparison to the grade of F) for writing-based ALM (39.1-43.3%, 95% CI [10.7-80.3%]), highly structured activities (16.4-22.2%, 95% CI [1.8-33.7%]), and in-class ALM (5.0-9.0%, 95% CI [0.6-13.8%]). Project-based and online ALM showed negative effects (lower likelihoods of receiving As, Bs, or Cs in comparison to the grade of F) with odds ratios of 15.7-20.9%, 95% CI [9.7-30.6%] and 16.1-20.4%, 95% CI [5.9-25.2%] respectively. A white paper was developed with recommendations for faculty development, computer skills assessment and training, and active research on writing-based ALM. Improving student grades and STEM course completion rates could lead to higher graduation rates and lower college costs for at-risk students by reducing course repetition and time to degree completion.

  1. The Hypocretin/Orexin Antagonist Almorexant Promotes Sleep Without Impairment of Performance in Rats

    Directory of Open Access Journals (Sweden)

    Stephen R Morairty

    2014-01-01

    Full Text Available The hypocretin receptor (HcrtR antagonist almorexant (ALM has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM. HcrtR antagonists are hypothesized to induce sleep by disfacilitation of wake-promoting systems whereas GABAA receptor modulators such as zolpidem (ZOL induce sleep through general inhibition of neural activity. To test the hypothesis that less functional impairment results from HcrtR antagonist-induced sleep, we evaluated the performance of rats in the Morris Water Maze in the presence of ALM vs. ZOL. Performance in spatial reference memory (SRM and spatial working memory (SWM tasks were assessed during the dark period after equipotent sleep-promoting doses (100 mg/kg, po following undisturbed and sleep deprivation (SD conditions. ALM-treated rats were indistinguishable from vehicle (VEH-treated rats for all SRM performance measures (distance travelled, latency to enter, time within, and number of entries into, the target quadrant after both the undisturbed and 6 h SD conditions. In contrast, rats administered ZOL showed impairments in all parameters measured compared to VEH or ALM in the undisturbed conditions. Following SD, ZOL-treated rats also showed impairments in all measures. ALM-treated rats were similar to VEH-treated rats for all SWM measures (velocity, time to locate the platform and success rate at finding the platform within 60 s after both the undisturbed and SD conditions. In contrast, ZOL-treated rats showed impairments in velocity and in the time to locate the platform. Importantly, ZOL rats only completed the task 23-50% of the time while ALM and VEH rats completed the task 79-100% of the time. Thus, following equipotent sleep-promoting doses, ZOL impaired rats in both memory tasks while ALM rats performed at levels comparable to VEH rats. These results are consistent with the hypothesis that less impairment results from HcrtR antagonism than from GABAA

  2. Asset liability management using stochastic programming

    OpenAIRE

    Pirbhai, M; Mitra, G; Kyriakis, T

    2003-01-01

    This chapter sets out to explain an important financial planning model called asset liability management (ALM); in particular, it discusses why in practice, optimum planning models are used. The ability to build an integrated approach that combines liability models with that of asset allocation decisions has proved to be desirable and more efficient in that it can lead to better ALM decisions. The role of uncertainty and quantification of risk in these planning models is con...

  3. What can article-level metrics do for you?

    Science.gov (United States)

    Fenner, Martin

    2013-10-01

    Article-level metrics (ALMs) provide a wide range of metrics about the uptake of an individual journal article by the scientific community after publication. They include citations, usage statistics, discussions in online comments and social media, social bookmarking, and recommendations. In this essay, we describe why article-level metrics are an important extension of traditional citation-based journal metrics and provide a number of example from ALM data collected for PLOS Biology.

  4. Alfalfa leaf meal in finishing steer diets. Quarterly report, July 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Zehnder, C.M.; DiCostanzo, A.; Smith, L.B.; Brown, D.B.; Hall, J.M.

    1997-10-30

    Ninety-six medium frame, Angus and Angus cross steer calves (average initial weight 540 lb.) were allotted to a heavy or light weight block and then randomly assigned to one of four dietary treatments for a 167 or 189-day finishing phase, respectively. Treatments were control (supplemental soybean meal), alfalfa leaf meal (ALM) providing 33%, 66%, 100% of supplemental protein. Finishing diets were formulated to contain .61 Mcal NE{sub g}/lb dry matter, 12.5% crude protein, .6 % Ca and .3 % P. There were no significant (P >.05) effects of dietary treatments on daily gain or dry matter required /lb of gain. Steers fed 100 % ALM consumed more (P <.05) dry matter than steers fed either of the other three treatments. Dry matter consumption increased linearly (P >.05) with increasing ALM. There was no significant (P >.05) dietary treatment effect on marbling, KPH %, yield grade, quality grade, or liver abscesses. There was an apparent trend in reduced liver abscess incidence in steers fed 100 % ALM. Steers fed 66 % ALM had significantly (P <.05) greater backfat measurements, backfat also had a cubic effect (P <.05). Hot carcass weight had a quadratic relation (P <.05) with level of ALM. Substituting alfalfa leaf meal for soybean meal in diets of finishing steers increased DM intake, but this increase was accompanied by an increase in gain which resulted in similar feed efficiency. There may be an advantage in blending ALM and soybean meal as feed efficiency was improved when cattle were fed the blend. Also, feeding ALM may result in lower incidence of liver abscess.

  5. Myynnin ja markkinoinnin parantaminen case Lady Line Tampere

    OpenAIRE

    Savolainen, Johanna

    2016-01-01

    Tämän opinnäytetyön tavoitteena oli kehittää myynnin ja markkinoinnin keinoja franchising-yrityksessä. Toimeksiantaja työlle oli Lady Line Tampereen toimitusjohtaja Jukka Heinola. Heinola omistaa Tampereen Lady Linen toimipisteen sekä Nokian Lady Linen toimipisteen. Lady Line on suomalainen naisten hyvinvointi ketju, joka on aloittanut toimintansa vuonna 1987 Vaasassa. Markkinoinnissa liikkumavaraa on jonkin verran, mutta rajoitteitakin löytyy kiitettävästi. Lady Linen jokainen keskus noudatt...

  6. ”Me kaikki voitetaan yhdessä” : Mitalijahti-peli varhaiskasvatuksen liikunnan apuvälineenä

    OpenAIRE

    Jukka, Maiju; Moilanen, Mikko

    2010-01-01

    Laurea-ammattikorkeakoulu Tiivistelmä Laurea Hyvinkää Sosiaalialan koulutusohjelma Lapsen ja perheen hyvinvoinnin vahvistaminen Jukka, Maiju ja Moilanen, Mikko ”Me kaikki voitetaan yhdessä” – Mitalijahti-peli varhaiskasvatuksen liikunnan apuvälineenä Vuosi 2010 Sivumäärä 52 Tämän opinnäytetyön aiheena on 3 – 5 -vuotiaan lapsen kehityksen tukeminen Mitalijahti lii-kuntapelin avulla. Mitalijahti on pieniin tiloihin soveltuva liikuntapeli, jonka avulla voidaan tuke...

  7. Kultuurkapitali aastapreemiad 2004 / Sverre Laanjärv

    Index Scriptorium Estoniae

    Laanjärv, Sverre

    2005-01-01

    Eesti Kultuurkapitali peapreemia sai Toomas Rank Rägavere mõisa ennistamise eest. Arhitektuuri sihtkapitali renoveerimispreemia - Mari Kurismaa, Eesti Draamateatri interjööride renoveerimine; objektipreemia - Martin Aunin, Ülemiste hotell; interjööripreemia - Jan Joonas Graps, Ken-Kristjan Ruut, "Jungenti" büroo; arhitektuurse tegevuse preemia - Veneetsia biennaali Eesti väljapaneku "Time Out Architecture" autorid (Kristjan Holm ning Liina Jänes, Agu Külm, Jukka-Pekka Jalovaara, Pille Epner, Madis Jürgen, Tõnu Kaalep, Ingmar Muusikus)

  8. Radiochemical analysis for nuclear waste management in decommissioning

    International Nuclear Information System (INIS)

    Hou, X.

    2010-07-01

    The NKS-B RadWaste project was launched from June 2009. The on-going decommissioning activities in Nordic countries and current requirements and problems on the radiochemical analysis of decommissioning waste were discussed and overviewed. The radiochemical analytical methods used for determination of various radionuclides in nuclear waste are reviewed, a book was written by the project partners Jukka Lehto and Xiaolin Hou on the chemistry and analysis of radionuclide to be published in 2010. A summary of the methods developed in Nordic laboratories is described in this report. The progresses on the development and optimization of analytical method in the Nordic labs under this project are presented. (author)

  9. Radiochemical analysis for nuclear waste management in decommissioning

    Energy Technology Data Exchange (ETDEWEB)

    Hou, X. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy. Radiation Research Div., Roskilde (Denmark))

    2010-07-15

    The NKS-B RadWaste project was launched from June 2009. The on-going decommissioning activities in Nordic countries and current requirements and problems on the radiochemical analysis of decommissioning waste were discussed and overviewed. The radiochemical analytical methods used for determination of various radionuclides in nuclear waste are reviewed, a book was written by the project partners Jukka Lehto and Xiaolin Hou on the chemistry and analysis of radionuclide to be published in 2010. A summary of the methods developed in Nordic laboratories is described in this report. The progresses on the development and optimization of analytical method in the Nordic labs under this project are presented. (author)

  10. Arhitektuuriaasta 2004 = The year in architecture 2004 / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2005-01-01

    Arhitektuuriauhindade nominentidest ja premeeritutest. Eesti Kultuurkapitali aastapreemia sai Toomas Rank Rägavere mõisa renoveerimise eest. Arhitektuuri sihtkapitali renoveerimispreemia - Mari Kurismaa, Eesti Draamateatri interjööride renoveerimine; objektipreemia - Martin Aunin, Ülemiste hotell; interjööripreemia - Jan Joonas Graps, Ken-Kristjan Ruut, "Jungenti" büroo; arhitektuurse tegevuse preemia - Kristjan Holm, Liina Jänes, Agu Külm, Jukka-Pekka Jalovaara, Pille Epner, Madis Jürgen, Tõnu Kaalep, Ingmar Muusikus, Eesti ekspositsioon "Aeg-maha-arhitektuur" Veneetsia arhitektuuribiennaalil

  11. Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women.

    Science.gov (United States)

    Mason, Caitlin; Xiao, Liren; Imayama, Ikuyo; Duggan, Catherine R; Foster-Schubert, Karen E; Kong, Angela; Campbell, Kristin L; Wang, Ching-Yun; Villasenor, Adriana; Neuhouser, Marian L; Alfano, Catherine M; Blackburn, George L; McTiernan, Anne

    2013-04-01

    The objective of this study is to investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on lean mass and the measurements defining sarcopenia in postmenopausal women and to examine the potential moderating effect of serum 25-hydroxyvitamin D (25(OH)D) and age. Four hundred thirty-nine overweight and obese postmenopausal women were randomized to diet modification (N = 118), exercise (N = 117), diet + exercise (N = 117), or control (N = 87). The diet intervention was a group-based program with a 10% weight loss goal. The exercise intervention was 45 min·d, 5 d·wk, of moderate-to-vigorous intensity aerobic activity. Total and appendicular lean mass (ALM) were quantified by dual x-ray absorptiometry at baseline and 12 months. A skeletal muscle index (SMI = ALM (kg) / height (m)) and the prevalence of sarcopenia (SMI exercise significantly preserved ALM and SMI. Diet + exercise attenuated the loss of ALM and SMI compared with diet alone and did not result in significant loss of total mass or ALM compared with controls. Neither serum 25(OH)D nor age was significant moderators of the intervention effects. Aerobic exercise added to dietary weight loss can attenuate the loss of ALM during weight loss and may be effective for the prevention and treatment of sarcopenia among overweight and obese postmenopausal women.

  12. Design and manufacture of high performance hollow engine valves by Additive Layer Manufacturing

    International Nuclear Information System (INIS)

    Cooper, D.; Thornby, J.; Blundell, N.; Henrys, R.; Williams, M.A.; Gibbons, G.

    2015-01-01

    Highlights: • High performance engine valve has been redesigned and optimised for and using ALM. • FEA was utilised to optimise and select a design for manufacture and testing. • Micro computed tomography was used in design and validation as an NDT technique. • Real world test of components was conducted to evaluate their performance. • Has demonstrated the potential for ALM in a high performance engineering context. - Abstract: Additive Layer Manufacture (ALM) of metallic components provides significant opportunities for the reduction of component weight, in order to realise improvements in vehicle fuel efficiency or performance. This paper examines the potential benefits of ALM with regard to reducing the weight of Internal Combustion Engine inlet or exhaust valves. A case study component is presented, for which an improved ALM design has been created, manufactured and evaluated. Micro-Computed Tomography (μ-CT) scanning was utilised to reverse engineer an original component, and to assess the ALM component’s internal geometry and material integrity. The case study valve was re-designed using Finite Element Analysis (FEA) to select a light weighted design which provides a conservative 9.4 g, (20%) weight saving on the Original Equipment Manufacturer (OEM) component. An engine test of over 175,000 cycles at between 2000 and 9500 rpm was conducted, after which μ-CT scanning confirmed no evidence of internal cracking, failure or significant deformation

  13. Modified high-dose melphalan and autologous SCT for AL amyloidosis or high-risk myeloma: analysis of SWOG trial S0115.

    Science.gov (United States)

    Sanchorawala, V; Hoering, A; Seldin, D C; Finn, K T; Fennessey, S A; Sexton, R; Mattar, B; Safah, H F; Holmberg, L A; Dean, R M; Orlowski, R Z; Barlogie, B

    2013-11-01

    We designed a trial using two sequential cycles of modified high-dose melphalan at 100 mg/m(2) and autologous SCT (mHDM/SCT) in AL amyloidosis (light-chain amyloidosis, AL), AL with myeloma (ALM) and host-based high-risk myeloma (hM) patients through SWOG-0115. The primary objective was to evaluate OS. From 2004 to 2010, 93 eligible patients were enrolled at 17 centers in the United States (59 with AL, 9 with ALM and 25 with hM). The median OS for patients with AL and ALM was 68 months and 47 months, respectively, and has not been reached for patients with hM. The median PFS for patients with AL and ALM was 38 months and 16 months, respectively, and has not been reached for patients with hM. The treatment-related mortality (TRM) was 12% (11/93) and was observed only in patients with AL after SCT. Grade 3 and higher non-hematologic adverse events were experienced by 81%, 67% and 57% of patients with AL, ALM and hM, respectively, during the first and second HDM/SCT. This experience demonstrates that with careful selection of patients and use of mHDM for SCT in patients with AL, ALM and hM, even in the setting of a multicenter study, OS can be improved with acceptable TRM and morbidity.

  14. Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.

    Science.gov (United States)

    Schwartz, Michael D; Nguyen, Alexander T; Warrier, Deepti R; Palmerston, Jeremiah B; Thomas, Alexia M; Morairty, Stephen R; Neylan, Thomas C; Kilduff, Thomas S

    2016-01-01

    Hypocretin 1 and 2 (Hcrts; also known as orexin A and B), excitatory neuropeptides synthesized in cells located in the tuberal hypothalamus, play a central role in the control of arousal. Hcrt inputs to the locus coeruleus norepinephrine (LC NE) system and the posterior hypothalamic histaminergic tuberomammillary nuclei (TMN HA) are important efferent pathways for Hcrt-induced wakefulness. The LC expresses Hcrt receptor 1 (HcrtR1), whereas HcrtR2 is found in the TMN. Although the dual Hcrt/orexin receptor antagonist almorexant (ALM) decreases wakefulness and increases NREM and REM sleep time, the neural circuitry that mediates these effects is currently unknown. To test the hypothesis that ALM induces sleep by selectively disfacilitating subcortical wake-promoting populations, we ablated LC NE neurons (LCx) or TMN HA neurons (TMNx) in rats using cell-type-specific saporin conjugates and evaluated sleep/wake following treatment with ALM and the GABAA receptor modulator zolpidem (ZOL). Both LCx and TMNx attenuated the promotion of REM sleep by ALM without affecting ALM-mediated increases in NREM sleep. Thus, eliminating either HcrtR1 signaling in the LC or HcrtR2 signaling in the TMN yields similar effects on ALM-induced REM sleep without affecting NREM sleep time. In contrast, neither lesion altered ZOL efficacy on any measure of sleep-wake regulation. These results contrast with those of a previous study in which ablation of basal forebrain cholinergic neurons attenuated ALM-induced increases in NREM sleep time without affecting REM sleep, indicating that Hcrt neurotransmission influences distinct aspects of NREM and REM sleep at different locations in the sleep-wake regulatory network.

  15. Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution

    International Nuclear Information System (INIS)

    Gao, Bin; Zhu, Shunyi

    2012-01-01

    Highlights: ► Al-M is an engineered fungal defensin with the n-loop of an insect defensin. ► Al-M adopts a native defensin-like structure with high antibacterial potency. ► Al-M kills bacteria through a membrane disruptive mechanism. ► This work sheds light on the functional evolution of CSαβ-type defensins. -- Abstract: Ancient invertebrate-type and classical insect-type defensins (AITDs and CITDs) are two groups of evolutionarily related antimicrobial peptides (AMPs) that adopt a conserved cysteine-stabilized α-helical and β-sheet (CSαβ) fold with a different amino-terminal loop (n-loop) size and diverse modes of antibacterial action. Although they both are identified as inhibitors of cell wall biosynthesis, only CITDs evolved membrane disruptive ability by peptide oligomerization to form pores. To understand how this occurred, we modified micasin, a fungus-derived AITDs with a non-membrane disruptive mechanism, by substituting its n-loop with that of an insect-derived CITDs. After air oxidization, the synthetic hybrid defensin (termed Al-M) was structurally identified by circular dichroism (CD) and functionally evaluated by antibacterial and membrane permeability assays and electronic microscopic observation. Results showed that Al-M folded into a native-like defensin structure, as determined by its CD spectrum that is similar to that of micasin. Al-M was highly efficacious against the Gram-positive bacterium Bacillus megaterium with a lethal concentration of 1.76 μM. As expected, in contrast to micasin, Al-M killed the bacteria through a membrane disruptive mechanism of action. The alteration in modes of action supports a key role of the n-loop extension in assembling functional surface of CITDs for membrane disruption. Our work provides mechanical evidence for evolutionary relationship between AITDs and CITDs.

  16. Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Bin [Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, 100101 Beijing (China); Zhu, Shunyi, E-mail: Zhusy@ioz.ac.cn [Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, 100101 Beijing (China)

    2012-10-05

    Highlights: Black-Right-Pointing-Pointer Al-M is an engineered fungal defensin with the n-loop of an insect defensin. Black-Right-Pointing-Pointer Al-M adopts a native defensin-like structure with high antibacterial potency. Black-Right-Pointing-Pointer Al-M kills bacteria through a membrane disruptive mechanism. Black-Right-Pointing-Pointer This work sheds light on the functional evolution of CS{alpha}{beta}-type defensins. -- Abstract: Ancient invertebrate-type and classical insect-type defensins (AITDs and CITDs) are two groups of evolutionarily related antimicrobial peptides (AMPs) that adopt a conserved cysteine-stabilized {alpha}-helical and {beta}-sheet (CS{alpha}{beta}) fold with a different amino-terminal loop (n-loop) size and diverse modes of antibacterial action. Although they both are identified as inhibitors of cell wall biosynthesis, only CITDs evolved membrane disruptive ability by peptide oligomerization to form pores. To understand how this occurred, we modified micasin, a fungus-derived AITDs with a non-membrane disruptive mechanism, by substituting its n-loop with that of an insect-derived CITDs. After air oxidization, the synthetic hybrid defensin (termed Al-M) was structurally identified by circular dichroism (CD) and functionally evaluated by antibacterial and membrane permeability assays and electronic microscopic observation. Results showed that Al-M folded into a native-like defensin structure, as determined by its CD spectrum that is similar to that of micasin. Al-M was highly efficacious against the Gram-positive bacterium Bacillus megaterium with a lethal concentration of 1.76 {mu}M. As expected, in contrast to micasin, Al-M killed the bacteria through a membrane disruptive mechanism of action. The alteration in modes of action supports a key role of the n-loop extension in assembling functional surface of CITDs for membrane disruption. Our work provides mechanical evidence for evolutionary relationship between AITDs and CITDs.

  17. THE ROLE OF VALUE AT RISK IN THE MANAGEMENT OF ASSET AND LIABILITIES

    Directory of Open Access Journals (Sweden)

    Petria Nicolae

    2012-12-01

    Full Text Available ALM is the management of risk at enterprise level, the models used in ALM can be static or dynamic: single period-static models, multiple period static model, single period stochastic model, multi period stochastic model. While single period-static don't incorporate the dynamic of the economical changes the multiple period-static models are an extension of the single period-static model, the most common used are multi-period stochastic which model the evolution of financial series in time and the assets and liabilities using different types of probability distributions (Student, GED. Highly correlated with ALM is the Value at Risk which can be used as and function to be minimized in ALM models. In the Value at Risk methodology the estimation models are classified as: parametric, nonparametric, semi-parametric; we present the parametric models (GARCH models used in Value at Risk and the connections that can be established between ALM models and Value at Risk. We present the Conditional Value-at-risk and offer and example on how to calculate CVaR .

  18. Effect of Alchornea cordifolia leaf meal inclusion and enzyme supplementation on performance and digestibility of rabbits

    Directory of Open Access Journals (Sweden)

    S.O. Ayodele

    2016-09-01

    Full Text Available A feeding trial was conducted to study the performance, digestibility and health status of weaner rabbits fed diets including Alchornea cordifolia leaf meal (ALM: 18% crude protein [CP] and 12.9% crude fibre and supplemented with a multi-enzyme additive (cellulase, xylanase, β-glucanase, α-amylase, protease, lipase. Six experimental diets were arranged factorially: 3 levels of ALM (0, 5 and 10% substituting palm kernel cake: 16.3% CP and 39.1% neutral detergent fibre combined with 2 levels of enzyme supplementation (0 and 0.35 g/kg. One hundred and eighty healthy, 5-wk-old weaner rabbits of cross-breeds were randomly allotted to 6 dietary treatments (30 rabbits/treatment, 3 rabbits/replicate. Growth rate was not affected (P>0.05 by the main factors (exogenous enzyme and ALM inclusion and their interactions (13.5 g/d on av.. Daily feed intake and feed conversion ratio decreased (P=0.01 with the ALM inclusion by 8%, but did not affect faecal digestibility. However, enzyme supplementation improved crude protein and crude fibre digestibility (P<0.001 by 6%. In conclusion, ALM inclusion and enzyme supplementation had no adverse effect on the performance and digestibility of rabbits.

  19. Improving simulated spatial distribution of productivity and biomass in Amazon forests using the ACME land model

    Science.gov (United States)

    Yang, X.; Thornton, P. E.; Ricciuto, D. M.; Shi, X.; Xu, M.; Hoffman, F. M.; Norby, R. J.

    2017-12-01

    Tropical forests play a crucial role in the global carbon cycle, accounting for one third of the global NPP and containing about 25% of global vegetation biomass and soil carbon. This is particularly true for tropical forests in the Amazon region, as it comprises approximately 50% of the world's tropical forests. It is therefore important for us to understand and represent the processes that determine the fluxes and storage of carbon in these forests. In this study, we show that the implementation of phosphorus (P) cycle and P limitation in the ACME Land Model (ALM) improves simulated spatial pattern of NPP. The P-enabled ALM is able to capture the west-to-east gradient of productivity, consistent with field observations. We also show that by improving the representation of mortality processes, ALM is able to reproduce the observed spatial pattern of above ground biomass across the Amazon region.

  20. Impact and productivity of Latin American publications about mathematics education

    Directory of Open Access Journals (Sweden)

    Aida Maria Torres-Alfonso

    2015-04-01

    Full Text Available More than a century room recently they have been carrying out, frequently annual Educational Mathematics Latin American Meetings (RELME and the works presented in the event, after a revision for even of experts, the ALME is published (Latin American Mathematics Education Act. We present a qualitative analysis of the impact of publications recorded in ALME in the period between 2000 and 2009. They use scientific production indicators, indicators of impact or influence: who provided the scientific community use made of these results based on the count of citations received by papers published in ALME in the publication itself, supplemented by an analysis of citations according to Google Scholar and collaboration indicators that showed the type of existing collaboration in the scientific community.

  1. Ciné-Club

    CERN Multimedia

    Ciné-Club

    2011-01-01

    Thursday 22 September at 20:30 Council Chamber / Salle du Conseil The English Patient By/de : Anthony Minghella (USA/UK, 1996) 162 min With/avec: Ralph Fiennes, Juliette Binoche, Willem Dafoe, Kristin Scott Thomas, Naveen Andrews, Colin Firth The English Patient tells the story of Count Almásy who is a Hungarian map maker employed by the Royal Geographical Society to chart the vast expanses of the Sahara Desert along with several other prominent explorers. As World War II unfolds, Almásy enters into a world of love, betrayal, and politics that is later revealed in a series of flashbacks while Almásy is on his death bed after being horribly burned in a plane crash. Original version English/V.O. anglaise Entrance: 2 CHF       Projection from DVD http://cineclub.web.cern.ch/Cineclub/

  2. Atrial angioleiomyoma with myopericytoma-like features: a case report.

    Science.gov (United States)

    Nassereddine, Hussein; Cazes, Aurélie; Verdonk, Constance; Assous, Benjamin; Dautry, Raphael; Nataf, Patrick; Wassef, Michel; Deschamps, Lydia

    A 66-year-old female patient was referred to our hospital for resection of a right atrial mass. Four months earlier, she had suffered an acute cerebrovascular accident due to occlusion of the sylvian segment of the right middle cerebral artery from atheromatous tight stenosis in the right internal carotid artery. Later, investigations with transthoracic and transesophageal echocardiography revealed a 3.4-cm right atrial mass that was resected surgically. Microscopic evaluation revealed a well-circumscribed nodular tumor, located within the interatrial septum, and corresponding to an angioleiomyoma (ALM). This tumor differs histologically from atrial myxoma. ALM is a ubiquitous benign tumor but has never been reported to occur in the atrium. ALM can mimic cardiac myxoma and should be considered in the differential diagnosis of atrial tumors. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Effect of garlic oil and four of its compounds on rumen microbial fermentation.

    Science.gov (United States)

    Busquet, M; Calsamiglia, S; Ferret, A; Carro, M D; Kamel, C

    2005-12-01

    Different concentrations (3, 30, 300, and 3000 mg/L of culture fluid) of garlic oil (GAR), diallyl sulfide (DAS), diallyl disulfide (DAD), allicin (ALL), and allyl mercaptan (ALM) were incubated for 24 h in diluted ruminal fluid with a 50:50 forage:concentrate diet (17.7% crude protein; 30.7% neutral detergent fiber) to evaluate their effects on rumen microbial fermentation. Garlic oil (30 and 300 mg/L), DAD (30 and 300 mg/L), and ALM (300 mg/L) resulted in lower molar proportion of acetate and higher proportions of propionate and butyrate. In contrast, at 300 mg/L, DAS only increased the proportion of butyrate, and ALL had no effects on volatile fatty acid proportions. In a dual-flow continuous culture of rumen fluid fed the same 50:50 forage:concentrate diet, addition of GAR (312 mg/L), DAD (31.2 and 312 mg/L), and ALM (31.2 and 312 mg/L) resulted in similar changes to those observed in batch culture, with the exception of the lack of effect of DAD on the proportion of propionate. In a third in vitro study, the potential of GAR (300 mg/L), DAD (300 mg/L), and ALM (300 mg/L) to decrease methane production was evaluated. Treatments GAR, DAD, and ALM resulted in a decrease in methane production of 73.6, 68.5, and 19.5%, respectively, compared with the control. These results confirm the ability of GAR, DAD, and ALM to decrease methane production, which may help to improve the efficiency of energy use in the rumen.

  4. Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study.

    Science.gov (United States)

    Mangano, Kelsey M; Sahni, Shivani; Kiel, Douglas P; Tucker, Katherine L; Dufour, Alyssa B; Hannan, Marian T

    2017-03-01

    Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns. Objective: We examined the prospective association of novel dietary protein food clusters (derived from established dietary pattern techniques) with appendicular lean mass (ALM), quadriceps strength (QS), and bone mineral density (BMD) in 2986 men and women, aged 19-72 y, from the Framingham Third Generation Study. Design: Total protein intake was estimated by food-frequency questionnaire in 2002-2005. A cluster analysis was used to classify participants into mutually exclusive groups, which were determined by using the percentage of contribution of food intake to overall protein intake. General linear modeling was used to 1 ) estimate the association between protein intake (grams per day) and BMD, ALM, appendicular lean mass normalized for height (ALM/ht 2 ), and QS (2008-2011) and to 2 ) calculate adjusted least-squares mean outcomes across quartiles of protein (grams per day) and protein food clusters. Results: The mean ± SD age of subjects was 40 ± 9 y; 82% of participants met the Recommended Daily Allowance (0.8 g · kg body weight -1 · d -1 ). The following 6 dietary protein food clusters were identified: fast food and full-fat dairy, fish, red meat, chicken, low-fat milk, and legumes. BMD was not different across quartiles of protein intake ( P -trend range = 0.32-0.82); but significant positive trends were observed for ALM, ALM/ht 2 ( P dietary protein is associated with ALM and QS but not with BMD. In this study, dietary protein food patterns do not provide further insight into beneficial protein effects on muscle outcomes. © 2017 American Society for Nutrition.

  5. End-to-end process of hollow spacecraft structures with high frequency and low mass obtained with in-house structural optimization tool and additive manufacturing

    Directory of Open Access Journals (Sweden)

    Alexandru-Mihai CISMILIANU

    2017-09-01

    Full Text Available In the space sector the most decisive elements are: mass reduction, cost saving and minimum lead time; here, structural optimization and additive layer manufacturing (ALM fit best. The design must be driven by stiffness, because an important requirement for spacecraft (S/C structures is to reduce the dynamic coupling between the S/C and the launch vehicle. The objective is to create an end-to-end process, from the input given by the customer to the manufacturing of an aluminum part as light as possible but at the same time considerably stiffer while taking the full advantage of the design flexibility given by ALM. To design and optimize the parts, a specialized in-house tool was used, guaranteeing a load-sufficient material distribution. Using topological optimization, the iterations between the design and the stress departments were diminished, thus greatly reducing the lead time. In order to improve and lighten the obtained structure a design with internal cavities and hollow beams was considered. This implied developing of a procedure for powder evacuation through iterations with the manufacturer while optimizing the design for ALM. The resulted part can be then manufactured via ALM with no need of further design adjustments. To achieve a high-quality part with maximum efficiency, it is essential to have a loop between the design team and the manufacturer. Topological optimization and ALM work hand in hand if used properly. The team achieved a more efficient structure using topology optimization and ALM, than using conventional design and manufacturing methods.

  6. Association between low lean mass and low bone mineral density in 653 women with hip fracture: does the definition of low lean mass matter?

    Science.gov (United States)

    Di Monaco, Marco; Castiglioni, Carlotta; Di Monaco, Roberto; Tappero, Rosa

    2017-12-01

    Loss of both muscle and bone mass results in fragility fractures with increased risk of disability, poor quality of life, and death. Our aim was to assess the association between low appendicular lean mass (aLM) defined according to different criteria and low bone mineral density (BMD) in hip-fracture women. Six hundred fifty-three women admitted to our rehabilitation hospital underwent dual energy X-ray absorptiometry 19.1 ± 4.1 (mean ± SD) days after hip-fracture occurrence. Low aLM was identified according to either Baumgartner's definition (aLM/height 2 less than two standard deviations below the mean of the young reference group) or FNIH criteria: aLM definition, the association between low aLM/height 2 and low BMD was significant: χ 2 (1, n = 653) = 8.52 (p = 0.004), but it was erased by adjustments for age and fat mass. Using the FNIH definition the association between low aLM and low BMD was significant: χ 2 (1, n = 653) = 42.5 (p definition based on aLM/BMI ratio the association between low aLM/BMI ratio and low BMD was nonsignificant: χ 2 (1, n = 653) = 0.003 (p = 0.957). The association between low aLM and low BMD in women with hip fracture dramatically depends on the adopted definition of low aLM. FNIH threshold for aLM (<15.02 kg) emerges as a useful tool to capture women with damage of the muscle-bone unit.

  7. Effect of a Hypocretin/Orexin Antagonist on Neurocogniive Performance

    Science.gov (United States)

    2014-09-01

    time: Tuesday , Nov 12, 2013, 4:00 PM - 5:00 PM Topic: ++E.08.e Sleep: Systems and behavior Authors: W. LINCOLN1, J. PALMERSTON1, T. NEYLAN2, T...functional impairment results from HcrtR antagonist-induced sleep, we evaluated the performance of rats in the Morris Water Maze in the presence of ALM vs. ZOL... Morris Water Maze. Although the concentrations of ALM and ZOL adminis- tered prior to these tests were equipotent in hypnotic efficacy, the

  8. Superallowed Fermi β decay studies at TRIUMF-ISAC

    Science.gov (United States)

    Svensson, C. E.; Dunlop, R.; Finlay, P.; Ball, G. C.; Ettenauer, S.; Leslie, J. R.; Towner, I. S.; Andreoiu, C.; Austin, R. A. E.; Bandyopadhyay, D.; Chagnon-Lessard, S.; Chester, A.; Cross, D. S.; Demand, G.; Djongolov, M.; Garnsworthy, A. B.; Garrett, P. E.; Green, K. L.; Glister, J.; Grinyer, G. F.; Hackman, G.; Hadinia, B.; Leach, K. G.; Pearson, C. J.; Phillips, A. A.; Rand, E. T.; Starosta, K.; Sumithrarachchi, C. S.; Tardiff, E. R.; Triambak, S.; Williams, S. J.; Wong, J.; Yates, S. W.; Zganjar, E. F.

    2013-10-01

    A program of high-precision superallowed Fermi β decay studies is being carried out at the Isotope Separator and Accelerator (ISAC) radioactive ion beam facility at TRIUMF. Recent high-precision branching ratio measurements for the superallowed decays of 74Rb and 26Alm, as well as a half-life measurement for 26Alm that is the most precise half-life measurement for any superallowed emitter to date, are reported. These results provide demanding tests of the theoretical isospin symmetry breaking corrections in superallowed Fermi β decays.

  9. High-precision half-life and branching-ratio measurements for superallowed Fermi β+ emitters at TRIUMF - ISAC

    Science.gov (United States)

    Laffoley, A. T.; Dunlop, R.; Finlay, P.; Grinyer, G. F.; Andreoiu, C.; Austin, R. A. E.; Ball, G. C.; Bandyopadhyay, D.; Blank, B.; Bouzomita, H.; Chagnon-Lessard, S.; Chester, A.; Cross, D. S.; Demand, G.; Diaz Varela, A.; Djongolov, M.; Ettenauer, S.; Garnsworthy, A. B.; Garrett, P. E.; Giovinazzo, J.; Glister, J.; Green, K. L.; Hackman, G.; Hadinia, B.; Jamieson, D. S.; Ketelhut, S.; Leach, K. G.; Leslie, J. R.; Pearson, C. J.; Phillips, A. A.; Rand, E. T.; Starosta, K.; Sumithrarachchi, C. S.; Svensson, C. E.; Tardiff, E. R.; Thomas, J. C.; Towner, I. S.; Triambak, S.; Unsworth, C.; Williams, S. J.; Wong, J.; Yates, S. W.; Zganjar, E. F.

    2014-03-01

    A program of high-precision half-life and branching-ratio measurements for superallowed Fermi β emitters is being carried out at TRIUMF's Isotope Separator and Accelerator (ISAC) radioactive ion beam facility. Recent half-life measurements for the superallowed decays of 14O, 18Ne, and 26Alm, as well as branching-ratio measurements for 26Alm and 74Rb are reported. These results provide demanding tests of the Standard Model and the theoretical isospin symmetry breaking (ISB) corrections in superallowed Fermi β decays.

  10. Using alfalfa leaf meal as a supplement in late-gestation beef heifer and nursing beef calf diets.

    Science.gov (United States)

    Zehnder, C M; Maddock, T D; DiCostanzo, A; Miller, L R; Hall, J M; Lamb, G C

    2010-06-01

    Two experiments were conducted to investigate using alfalfa leaf meal (ALM; 22% CP, DM basis) in beef cattle diets. In Exp. 1, a total of 24 late-gestation Angus heifers (initial BW 470 +/- 9 kg) were blocked by BW, calving date, and BCS to 1 of 4 dietary treatments in a randomized complete block design. All heifers were offered a basal hay diet (7.4% CP and 67.6% NDF, DM basis). Treatments were arranged as a 2 x 2 factorial consisting of CP supplied at 100 or 112.5% of the recommended daily intake using either soybean meal (SBM) or ALM as the supplemental protein source. Treatments were fed for an average of 100 d before calving. Total DMI was unaffected by supplemental protein source, although heifers consumed more (P Feeding 112.5% of recommended CP to heifers increased precalving rate of BW gain (P = 0.004) and DM digestibility (P = 0.003). Protein source did not affect DM digestibility (P = 0.17). Neither supplemental protein source nor protein amount affected changes in BCS or calving traits. In Exp. 2, replicates of treatments were conducted over 2 consecutive years at 2 locations in northern Minnesota to determine the effects of including ALM in creep-fed supplements on nursing calf performance, supplement BW gain efficiency (GF; BW gain over control/supplement intake), and cow performance. Treatments were control (no supplement), ALM supplement (58% ALM, as-fed basis), or a wheat middling- and soybean hull-based supplement (MIDD). Milk intake (estimated by the weigh-suckle-weigh technique) was similar among treatments. Creep-fed calves had greater (P creep feed DMI than those offered ALM (2.6 vs. 1.3 kg/d, respectively). A year x treatment interaction was noted for GF (P = 0.02). In yr 1, GF for calves offered ALM was greater (P = 0.006) than GF for calves offered MIDD, but in yr 2, there were no differences. Alfalfa leaf meal may substitute for SBM in beef heifer wintering diets and conventional creep feed ingredients. When included in creep feed diets

  11. Hysteresis properties of local region of morphous-crystalline alloy. Gisterezisnye svojstva lokal'nogo uchastka amorfnokristallicheskogo splava

    Energy Technology Data Exchange (ETDEWEB)

    Kryukov, I I [Irkutskij Pedagogicheskij Inst., Irkutsk (Russian Federation)

    1991-09-01

    Fields of H{sub 3} domain boundary pinning on an amorphous interlayer d thick, separating neighbouring crystallites, the axes of light magnetization (ALM) of which are disoriented, were calculated by numerical methods for amorpthous-crystalline alloy (ACA). At d=0 and d={infinity} analytical expressions were obtained for H{sub p}. It is shown that ALM dispersion of the crystallites to a considerable extent determines hysteresis properties of ACA and can be responsible for bends on magnetization and remagnetization curves, dependence of hysteresis properties of magnetizing field amplitude and the sample prehistory.

  12. Age- and gender-dependent values of skeletal muscle mass in healthy children and adolescents

    OpenAIRE

    Webber, Colin E.; Barr, Ronald D.

    2011-01-01

    Background Skeletal muscle mass (SMM) can be extracted from whole-body scans obtained by X-ray-based dual-photon absorptiometry (DXA). There is a need to establish expected age-dependent values for children and adolescents. Methods Appendicular lean tissue mass (ALM) was extracted from whole-body DXA scans in 140 healthy children and adolescents (68 females and 72 males). Whole-body SMM was calculated from ALM using equations developed by Kim et al. (Am J Clin Nutr 84:1014–1020, 2006). Age-de...

  13. Physics colloquium: Single-electron counting in quantum metrology and in statistical mechanics

    CERN Multimedia

    Geneva University

    2011-01-01

    GENEVA UNIVERSITY Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Genève 4 Tél.: (022) 379 62 73 Fax: (022) 379 69 92olé   Lundi 17 octobre 2011 17h00 - Ecole de Physique, Auditoire Stueckelberg PHYSICS COLLOQUIUM « Single-electron counting in quantum metrology and in statistical mechanics » Prof. Jukka Pekola Low Temperature Laboratory, Aalto University Helsinki, Finland   First I discuss the basics of single-electron tunneling and its potential applications in metrology. My main focus is in developing an accurate source of single-electron current for the realization of the unit ampere. I discuss the principle and the present status of the so-called single- electron turnstile. Investigation of errors in transporting electrons one by one has revealed a wealth of observations on fundamental phenomena in mesoscopic superconductivity, including individual Andreev...

  14. Tim Berners-Lee receives the Millennium Technology Prize

    CERN Multimedia

    2004-01-01

    On 15 April, for his invention of the Web, Tim Berners-Lee was awarded the first ever Millennium Technology Prize by the Finnish Technology Award Foundation, which recognises technological innovations of lasting benefit to society. "Tim Berners-Lee's invention perfectly encapsulates the spirit of the Prize. The Web is encouraging new types of social networks, contributing to transparency and democracy, and opening up new avenues for information management and business development," underlined Pekka Tarjanne, chairman of the jury and former Secretary-General of the International Telecommunication Union (ITU). Tim Berners-Lee is congratulated by Jukka Valtasaari, Finland's Ambassador to the United States. Tim Berners-Lee created the first server, browser and editor, the HTML code, the URL address and the HTTP transmission protocol at CERN in 1990. CERN released the Web into the public domain in 1993. Tim Berners-Lee is currently head of the World Wide Web Consortium, managed by ERCIM (Europe...

  15. And now, for the winners.

    CERN Multimedia

    Alizée Dauvergne

    2010-01-01

    The Computer Security Day held on 10 June was a success. There were eight presentations, with some forty people attending each session.     The presentation videos can be viewed on Indico. The computer security team’s new website is now up and running, with a wealth of useful information and advice. Go to http://cern.ch/Computer.Security.     The quiz attracted 130 participants, and the answers have now been posted on line! The quiz winners are: Lars Aprin, Richard Baud, Thibaut Bernard, Brice Copy, Daniele de Ruschi, Sébastien Gadrat, Amanda Garcia Munoz, Stephen Gowdy, Joni Hahkala, Joseph Izen, Ryszard Erazm Jurga, Jukka Klem, Danila Oleynik, Ian Pong, Pascal Serge Roguet, Jani Tapani Taskinen, Jan Therhaag, Yves Thurel, Adrian Vogel, Thomas White. Well done to all! If you haven’t done so already, you should soon be getting your prize (i.e. a book, a T-shirt or a bag, etc.).  

  16. ASGE leadership: promoting or validating endoscopic technology ...

    African Journals Online (AJOL)

    No Abstract Available South African Gastroenterology Review Vol.2(3) 2004: 1. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/sagr.v2i3.30717 · AJOL African Journals Online.

  17. South African Gastroenterology Review

    African Journals Online (AJOL)

    Fees for medical services: money and medicine. Carl Schulenburg. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  18. South African Gastroenterology Review

    African Journals Online (AJOL)

    IBS - the beginning and the end: clinical review. Keith Pettengell. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/sagr.v1i1.30693 · AJOL African Journals Online. HOW TO USE ...

  19. Traveller's diarrhoea | Girwood | South African Gastroenterology ...

    African Journals Online (AJOL)

    No Abstract South African Gastroentorology Review Vol. 5 (2) 2007: pp. 4-6. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for ...

  20. Cultural Understanding: Spanish Level 1.

    Science.gov (United States)

    Scott, Reid

    The teacher's attention is focused on selected elements of Spanish culture which may be taught integrally with instructional materials found in the first-year Spanish texts "Entender y Hablar", "La Familia Fernandez", and "A-LM Spanish, Level One". Items are cross-referenced for 42 cultural concepts ranging from nicknames to streets, roads, and…

  1. Economic Growth, Productivity, and Public Education Funding: Is South Carolina a Death Spiral State?

    Science.gov (United States)

    Driscoll, Lisa G.; Knoeppel, Robert C.; Della Sala, Matthew R.; Watson, Jim R.

    2014-01-01

    As a result of the Great Recession of 2007-2009, most states experienced declines in employment, consumer spending, and economic productivity (Alm, Buschman, and Sjoquist 2011). In turn, these events led to historic declines in state tax revenues (Mikesell and Mullins 2010; Boyd and Dadayan 2009), resulting in major cuts in public spending. Local…

  2. Peer-to-Peer Learning and the Army Learning Model

    Science.gov (United States)

    2012-06-08

    education will be delivered to the current and future force. This thesis examined the salient areas proposed by the ALM and its impact on P2P learning ...The Army Learning Model is the new educational model that develops adaptive leaders in an era of persistent conflict. Life-long, individual

  3. Cracks show in African Commission | Daniels | Africa Insight

    African Journals Online (AJOL)

    Far from providing leadership, the African Commission is riven with regional, linguistic and religious rivalries. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/ai.v31i4.22383 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER ...

  4. Playing games with religion in education | Roux | South African ...

    African Journals Online (AJOL)

    No Abstract. South African Journal of Education Vol. 23 (2) 2003: pp. 130-134. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy ...

  5. Uygulama yasam döngüsü yönetimi - Sistematik esleme çalismasi

    NARCIS (Netherlands)

    Aytekin, Ahsen Ikbal; Tüzün, Eray; Macit, Yagup; Tekinerdogan, Bedir

    2015-01-01

    Application Lifecycle Management (ALM) can be defined as an approach that is starting from the idea of a software application and continuing with development, deployment and maintenance process. The overall objective of this study is evaluating the publications about Application Lifecycle

  6. Editorial: On Changing Jackets | Thomson | South African Actuarial ...

    African Journals Online (AJOL)

    No Abstract South African Actuarial Journal Vol. 8 2008: pp. 93-95. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/saaj.v8i1.24514 · AJOL African Journals Online. HOW TO USE ...

  7. Radioactiva contamination of food in the USSR, sampled in regions contaminated by the Chernobyl disaster, and of radioactive exposure in these regions (Cs-137 and K-40 in food)

    NARCIS (Netherlands)

    Ruig, de W.G.; Struijs, van der T.D.B.

    1991-01-01

    From 21.10.1990 to 01.11.1990 a Netherlands humanitarian fact finding mission on aid to people affected by the Chernobyl disaster visited the USSR. The Netherlands Government reacted positively to a request trom the USSR tor such aid and the alm of the mission was to gather facts tor a useful aid

  8. The impact of house price index specification levels on the risk profile of housing corporations

    NARCIS (Netherlands)

    Kramer, B.; Kuijl, T.; Francke, M.

    2009-01-01

    Asset Liability Management (ALM) for housing corporations is based on stochastic scenario models for important risk and return drivers such as interest and inflation rates, construction costs and sales prices of houses. Given the situation of the housing corporation (current real estate portfolio,

  9. Dicty_cDB: VSG387 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available none) Arenicola marina ribosomal protein... 57 3e-07 BC077676_1( BC077676 |pid:no...ne) Xenopus tropicalis Finkel-Biskis-R... 57 3e-07 protein update 2009. 3.23 PSORT psg: 0.28 gvh: 0.24 alm:

  10. Local economic regeneration in the fishing industry: a case study ...

    African Journals Online (AJOL)

    Local economic regeneration in the fishing industry: a case study. HR Lloyd, GS Horn. Abstract. Africa Insight Vol.33(4) 2003: 33-39. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  11. Effect of short-term pre-hatch heat shock of incubating eggs on ...

    African Journals Online (AJOL)

    The six-week live weight of the heat-treated group (2098 ± 12.0 g) was significantly lower than that of the control (2143 ± 12.2 g). The 1-6 ... 1.77 ± 0.03 for the treatment vs. control groups, respectively, but the ... Metrics powered by PLOS ALM

  12. Two "grand stories" about good practice in adult numeracy teaching - taking stock of our area

    DEFF Research Database (Denmark)

    Johansen, Lene Østergaard

    2008-01-01

      Writing my doctoral thesis I had to write a chapter describing the work of the international Research Forum "Adults Learning Mathematics" (ALM) to positioning my own work in this landscape of investigating. For me this was a very difficult task while a lot of my colleagues all over the world al...

  13. 32 CFR 234.13 - Soliciting, vending, and debt collection.

    Science.gov (United States)

    2010-07-01

    ... advertising, collecting private debts or soliciting alms upon the Pentagon Reservation is prohibited. This..., advertising to sell or rent property of Pentagon Reservation employees or their immediate families. (c... or for the benefit of welfare funds for their members, after compliance with the requirements of...

  14. Relationship between Active Learning Methodologies and Community College Students' STEM Course Grades

    Science.gov (United States)

    Lesk, Cherish Christina Clark

    2017-01-01

    Active learning methodologies (ALM) are associated with student success, but little research on this topic has been pursued at the community college level. At a local community college, students in science, technology, engineering, and math (STEM) courses exhibited lower than average grades. The purpose of this study was to examine whether the use…

  15. Dicty_cDB: SFC789 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ments: (bits) Value N AF305060 |AF305060.1 Dictyostelium discoideum Wiscott-Aldri...ne) Dictyostelium discoideum Wiscott-A... 34 0.031 protein update 2009. 1. 7 PSORT psg: 0.84 gvh: 0.42 alm:

  16. All lands approaches to fire management in the Pacific West: a typology

    Science.gov (United States)

    Susan Charnley; Erin C. Kelly; Kendra L. Wendel

    2017-01-01

    Since 2009, the US Department of Agriculture Forest Service has promoted an “all lands approach” to forest restoration, particularly relevant in the context of managing wildfire. To characterize its implementation, we undertook an inventory of what we refer to as fire-focused all lands management (ALM) projects, defined as projects in which fuels reduction treatments...

  17. Mutations in Alström protein impair terminal differentiation of cardiomyocytes.

    Science.gov (United States)

    Shenje, Lincoln T; Andersen, Peter; Halushka, Marc K; Lui, Cecillia; Fernandez, Laviel; Collin, Gayle B; Amat-Alarcon, Nuria; Meschino, Wendy; Cutz, Ernest; Chang, Kenneth; Yonescu, Raluca; Batista, Denise A S; Chen, Yan; Chelko, Stephen; Crosson, Jane E; Scheel, Janet; Vricella, Luca; Craig, Brian D; Marosy, Beth A; Mohr, David W; Hetrick, Kurt N; Romm, Jane M; Scott, Alan F; Valle, David; Naggert, Jürgen K; Kwon, Chulan; Doheny, Kimberly F; Judge, Daniel P

    2014-03-04

    Cardiomyocyte cell division and replication in mammals proceed through embryonic development and abruptly decline soon after birth. The process governing cardiomyocyte cell cycle arrest is poorly understood. Here we carry out whole-exome sequencing in an infant with evidence of persistent postnatal cardiomyocyte replication to determine the genetic risk factors. We identify compound heterozygous ALMS1 mutations in the proband, and confirm their presence in her affected sibling, one copy inherited from each heterozygous parent. Next, we recognize homozygous or compound heterozygous truncating mutations in ALMS1 in four other children with high levels of postnatal cardiomyocyte proliferation. Alms1 mRNA knockdown increases multiple markers of proliferation in cardiomyocytes, the percentage of cardiomyocytes in G2/M phases, and the number of cardiomyocytes by 10% in cultured cells. Homozygous Alms1-mutant mice have increased cardiomyocyte proliferation at 2 weeks postnatal compared with wild-type littermates. We conclude that deficiency of Alström protein impairs postnatal cardiomyocyte cell cycle arrest.

  18. Additive Layer Manufacturing for Launcher's Applications

    Science.gov (United States)

    Vilanova, J.; Romera, P.; Lasagni, F.; Zorrilla, A.; Perinan, A.

    2014-06-01

    In the next years the European space industry has the challenge of maintaining its competitiveness in launch vehicles (LV) production, due to the growth of competition worldwide. It has to assure its position developing new applied technologies. In this field the effort is focussed on the production of short series of customized products, like payloads, flight components or launcher parts. ALM (Additive Layer Manufacturing) could be a powerful tool that offers new competitiveness factors for this industry, comprising a set of emerging technologies that are becoming a competitor to forming, casting and machining as well as being utilised directly as a complementary alternative.Originally used for prototypes and models, now ALM becomes a very useful technology capable to fabricate functional parts for the space industrial sector. Its demands on rapid technologies are different to "earth" industries, and they aren't so easily satisfied because space is a field with different requirements depending on its application: launchers, reusable vehicles, satellites, probes, low gravity researches, manned spacecraft, or even moon and planetary exploration.This paper reports on the ALM potential applications, under ESA requirements, exploring the challenges and possibilities for its use in the launchers market, trying to answer two basic questions: the first one, whether ALM is a mature technology to be ready for its use as flight hardware; and the second one, if it can be used to reduce the product cycle, and consequently, the development, production and operational costs.

  19. 77 FR 3611 - Approval and Promulgation of Implementation Plans; North Carolina: Approval of Section 110(a)(1...

    Science.gov (United States)

    2012-01-25

    ... Carolina developed comprehensive inventories of volatile organic compounds (VOC) and nitrogen oxides (NO X ) emissions from area, point, on-road mobile, non-road mobile (including aircraft, locomotive and marine (ALM..., and Volatile organic compounds. Authority: 42 U.S.C. 7401 et seq. Dated: January 12, 2012. A. Stanley...

  20. 75 FR 62354 - Approval and Promulgation of Implementation Plans; Tennessee: Approval of Section 110(a)(1...

    Science.gov (United States)

    2010-10-08

    ... comprehensive inventories of volatile organic compounds (VOC) and nitrogen oxide (NO X ) emissions from area, point, on-road mobile, non-road mobile, and aircraft, locomotive, and commercial marine (ALM) sources... organic compounds. Authority: 42 U.S.C. 7401 et seq. Dated: September 28, 2010. Gwendolyn Keyes Fleming...

  1. Abeeb olufemi Salaam Community Reintegration Oyo, Oyo State ...

    African Journals Online (AJOL)

    High rates of cannabis, tobacco (nicotine), rophynol, codeine ... their children in Islamic education, called alm- ajiri (Abdulmalik ... cause there are few resources at the teachers' disposal .... graphic profiles, different types of drug and ..... (1996). Drug use among street in southern. Brazil. Drug and Alcohol Dependence, 43.

  2. Genotypic frequency of calpastatin gene in lori sheep by polymerase ...

    African Journals Online (AJOL)

    Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · FAQ's · News · AJOL jobs · More about AJOL ...

  3. New advances in cystic fibrosis - implications for developing countries

    African Journals Online (AJOL)

    New advances in cystic fibrosis - implications for developing countries. Heather J Zar, Eric Bateman, Michelle Ramsay. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM.

  4. Comportement à la corrosion intrinsèque de couches minces à base ...

    African Journals Online (AJOL)

    Comportement à la corrosion intrinsèque de couches minces à base d'aluminium (Al-M: M=Mo, Mg, ... Département de Physique, Université Badji Mokhtar, BP 12, Annaba 23000, Algérie. .... dépôts réalisés sur substrat en verre servent pour la ...

  5. Effects of soil mesofauna and microclimate on nitrogen dynamics in ...

    African Journals Online (AJOL)

    Jane

    2011-07-13

    Jul 13, 2011 ... In this paper, carbon (C) and N dynamics in decomposing. Castanopsis ... between litter wet and dry weights divided by the dry weight and ..... 45. 55. 65. 75. EVB. COF. DWF. ALM sites. M e a n a n n u a. l a ir te m p e ra tu re.

  6. Developing reading in a first-year academic literacy course

    African Journals Online (AJOL)

    KATEVG

    and critically with ideas in text and elsewhere; produce well-reasoned ... that knit discourse and signal sequences in texts, such as cause-effect, ... detecting the author's purpose or bias; ..... the ALM104 course become a research site where action research projects may ... PASS/FAIL of the first and later years of study; and.

  7. Library development in selected private secondary schools in Lagos ...

    African Journals Online (AJOL)

    44. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/ljlis.v2i1.35501 · AJOL African Journals ...

  8. Neurotrophic regulation of epidermal dedifferentiation during wound healing and limb regeneration in the axolotl (Ambystoma mexicanum).

    Science.gov (United States)

    Satoh, A; Graham, G M C; Bryant, S V; Gardiner, D M

    2008-07-15

    Adult urodeles (salamanders) are unique in their ability to regenerate complex organs perfectly. The recently developed Accessory Limb Model (ALM) in the axolotl provides an opportunity to identify and characterize the essential signaling events that control the early steps in limb regeneration. The ALM demonstrates that limb regeneration progresses in a stepwise fashion that is dependent on signals from the wound epidermis, nerves and dermal fibroblasts from opposite sides of the limb. When all the signals are present, a limb is formed de novo. The ALM thus provides an opportunity to identify and characterize the signaling pathways that control blastema morphogenesis and limb regeneration. In the present study, we have utilized the ALM to identity the buttonhead-like zinc-finger transcription factor, Sp9, as being involved in the formation of the regeneration epithelium. Sp9 expression is induced in basal keratinocytes of the apical blastema epithelium in a pattern that is comparable to its expression in developing limb buds, and it thus is an important marker for dedifferentiation of the epidermis. Induction of Sp9 expression is nerve-dependent, and we have identified KGF as an endogenous nerve factor that induces expression of Sp9 in the regeneration epithelium.

  9. Alstrom syndrome (OMIM 203800: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Hegele Robert A

    2007-12-01

    Full Text Available Abstract Background Alstrom syndrome (AS is a rare autosomal recessive disease characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss. Associated endocrinologic features include hyperinsulinemia, early-onset type 2 diabetes, and hypertriglyceridemia. Thus, AS shares several features with the common metabolic syndrome, namely obesity, hyperinsulinemia, and hypertriglyceridemia. Mutations in the ALMS1 gene have been found to be causative for AS with a total of 79 disease-causing mutations having been described. Case presentation We describe the case of a 27-year old female from an English (Caucasian kindred. She had been initially referred for hypertriglyceridemia, but demonstrated other features suggestive of AS, including blindness, obesity, type 2 diabetes, renal dysfunction, and hypertension. DNA analysis revealed that she is a compound heterozygote with two novel mutations in the ALMS1 gene – H3882Y and V424I. Examination of her family revealed that her phenotypically unaffected mother and younger sister also had heterozygous mutations in the ALMS1 gene. In addition to presenting these novel molecular findings for AS, we review the clinical and genetic features of AS in the context of our case. Conclusion Two novel mutations in the ALMS1 gene causative for AS have been reported here, thereby increasing the number of reported mutations to 81 and providing a wider basis for mutational screening among affected individuals.

  10. Asset liability management modeling using multi-stage mixed-integer stochastic programming

    NARCIS (Netherlands)

    Drijver, S.J.; Klein Haneveld, W.K.; van der Vlerk, Maarten H.

    2000-01-01

    A pension fund has to match the portfolio of long-term liabilities with the portfolio of assets. Key instruments in strategic Asset Liability Management (ALM) are the adjustments of the contribution rate of the sponsor and the reallocation of the investments in several asset classes at various

  11. Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors.

    Science.gov (United States)

    Ryan, Alice S; Ivey, Frederick M; Serra, Monica C; Hartstein, Joseph; Hafer-Macko, Charlene E

    2017-03-01

    To determine the prevalence of sarcopenia in stroke survivors using different methodologies, and compare a subset of the stroke group to age-, sex-, and body mass index (BMI)-matched nonstroke control counterparts. Cohort study. A Veterans Affairs medical center and a university hospital. Mild to moderately disabled participants >6 months after onset of stroke aged 40 to 84 years (N=190, 61% men, 57% African American; mean BMI ± SEM, 29±1kg/m 2 ). Not applicable. Dual-energy x-ray absorptiometry scans to assess appendicular lean mass (ALM). Rates of sarcopenia were determined using 4 established methods: (1) ALM/height 2 (ALM/ht 2 ); (2) European Working Group on Sarcopenia in Older Persons; (3) International Working Group on Sarcopenia; and (4) ALM/BMI. Sarcopenia prevalence in our stroke cohort ranged between 14% and 18%. The stroke survivor subset (n=38) matched one-for-one with control counterparts for race, sex, age ±4 years and BMI ±2.5kg/m 2 had higher prevalence rates compared with their nonstroke counterparts (13.2% vs 5.3%, Psarcopenia when considering age, sex, and race compared with nonstroke individuals. Published by Elsevier Inc.

  12. International Conference on Composite Structures (7th), Held in United Kingdom, July 1993. Volume 25, Numbers 1 - 4

    Science.gov (United States)

    1993-07-01

    McGravk-Hlill. Now York. Chaptcr 4. 1975. SM thesis. Departmcnt of Aeronautics and Astro - 10, Lee, 1). 6i., Kim. K. S. & In. Y. T.. An experimental nautics...platte stiffness, where fied analte, sical ,lyuigathe fxc -initte l alm nt Netin thle maimumIILII energy dissipation results inl a large’ systeml damping

  13. Albizia lebbeck seed methanolic extract as a complementary therapy to manage local toxicity of Echis carinatus venom in a murine model.

    Science.gov (United States)

    Amog, P U; Manjuprasanna, V N; Yariswamy, M; Nanjaraj Urs, A N; Joshi, Vikram; Suvilesh, K N; Nataraju, A; Vishwanath, Bannikuppe Sannanaik; Gowda, T V

    2016-11-01

    Viperid venom-induced chronic local-toxicity continues even after anti-snake venom treatment. Therefore, traditional antidote Albizia lebbeck L. (Fabaceae) seed extract was tested against Echis carinatus S. (Viperidae) venom (ECV)-induced local toxicity to evaluate its complementary remedy. Soxhlet extraction of A. lebbeck seeds was performed with the increasing polarity of solvents (n-hexane to water); the extract was screened for phytochemicals (alkaloids, anthraquinones, flavonoids, glycosides, phenolics, saponins, steroids and tannins). In preliminary in vitro analysis, A. lebbeck methanolic extract (ALME) demonstrated significant inhibition of ECV proteases, the major enzyme-toxin responsible for local- toxicity. Therefore, in vitro neutralizing potential of ALME was further evaluated against hyaluronidases and phospholipase A 2 (1:1-1:100 w/w). In addition, alleviation of ECV induced characteristic local- toxicity [haemorrhage (i.d.) and myotoxicity (i.m.)] was determined in mice. ALME contained high concentrations of phenolics and flavonoids and demonstrated significant in vitro inhibition of ECV protease (IC 50  =   36.32 μg, p lebbeck in complementary medicine and identifies ALME as principle fraction responsible for antivenom properties.

  14. Rail Sensor Testbed Program: Active Agents in Containers for Transport Chain Security

    Science.gov (United States)

    2011-01-01

    applied to a variety of regimes, including virtual communities [14], email [15] and ecommerce [16] and [17], and sensor networks [18]. These approaches...effective anti- spam tool. 2004(http://www.arxiv.org/abs/cond-mat/0402143). 16. Melnik, M., Alm, J., Does a seller’s eCommerce reputation matter

  15. Paul Halmos – Expositor Par Excellence

    Indian Academy of Sciences (India)

    Administrator

    com plished P hD student of H alm os { w rites about his extraordinary ..... gies on the set ofm easure-preserving transform ations of. a m easure .... reer and book-w riting skills w ere o® and running. ... She still lives at L os G atos, C alifor- nia.

  16. Liver biopsy - the current view? | Beningfield | SA Journal of Radiology

    African Journals Online (AJOL)

    No Abstract South African Journal of Radiology Vol. 10 (4) 2006: pp. 4-6. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4102/sajr.v10i4.149 · AJOL African Journals ...

  17. Digital content licenses, a barrier to digital content?: A South African ...

    African Journals Online (AJOL)

    Digital content licenses, a barrier to digital content?: A South African survey. C Masango. Abstract. No Abstract. Innovation Vol.34 () 2007: pp. 51-66. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  18. Automated acquisition: principles and practice | Ezomo | Lagos ...

    African Journals Online (AJOL)

    No Abstract. Lagos Journal of Library and Information Science Vol. 1(2) 2003: 120-124. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/ljlis.v1i2.35486 · AJOL African Journals ...

  19. Globalisation, social values and human rights NGOs in Nigeria ...

    African Journals Online (AJOL)

    Globalisation, social values and human rights NGOs in Nigeria. Edlyne E Anugwom. Abstract. (Africa Insight: 2002 32(4): 21-27). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  20. 1388-IJBCS-Article-Melia Mamatchi+

    African Journals Online (AJOL)

    KODJIO NORBERT

    Ecologie du Développement Durable,. INERIS, Paris. Alméida J-A, Diniz Y-S, Marques S-F-G,. Faine L-A, Ribas B-O, Burneiko R-C,. Novelli E-L-B. 2002. The use of the oxydative stress response as biomarkers in Nile tilapia (Oreochromis niloticus).

  1. JPRS Report, Proliferation Issues

    Science.gov (United States)

    1992-06-25

    control of INGTON POST saying: "Secretary of Defense Richard Nuclemon Minero Quimica Ltda. [Nuclebras Monazite and Cheney approved the Pentagon’s plan ... Planned [Alm a-Ata Radio] .................................................................................................. 26 Krasnoyarsk Search for...34 [Article by political staff: "Space plan defended"] He said the aim of the investigation was to determine the market opportunities, risks and

  2. Dicty_cDB: VHI131 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AJ271965_3( AJ271965 |pid:none) Transmissible gastroenteritis viru... 35 4.4 AY452031_1( AY452031 |pid:none) Feline infectious perito...nitis viru... 35 4.4 protein update 2009. 7.13 PSORT psg: 1.00 gvh: 0.65 alm: 0.51

  3. Explicit teaching of grammar and improvement in the grammar of ...

    African Journals Online (AJOL)

    Explicit teaching of grammar and improvement in the grammar of student writing. J Parkinson. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  4. Splenectomy in a rural surgical practice | Alufohai | Nigerian Journal ...

    African Journals Online (AJOL)

    No Abstract. Nigrian Journal of Clinical Practice Vol.9 (1) 2006: pp.81-83. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL.

  5. Monogenic diabetes syndromes

    DEFF Research Database (Denmark)

    Astuti, Dewi; Sabir, Ataf; Fulton, Piers

    2017-01-01

    (n = 268), and SLC19A2 (n = 48) for Wolfram type 1, Wolfram type 2, Alström, and Thiamine-responsive megaloblastic anemia syndromes, respectively; and included 23 previously unpublished novel germline variants in WFS1 and 17 variants in ALMS1. We then investigated genotype-phenotype relations...

  6. 2365-IJBCS-Article-Mamoudou Abdoul

    African Journals Online (AJOL)

    hp

    Livestock diseases especially cattle trypanosomiasis remains a challenge and a call for concern. A. Cross sectional study was carried out on the entomological and parasitological prevalence of cattle trypanosomiasis, in the tsetse fly infested zone-Alme in Faro and Deo division, Adamaoua region Cameroon. The aim of this ...

  7. Written on the Body: Meaning, Gender | Distiller | Shakespeare in ...

    African Journals Online (AJOL)

    No Abstract. Shakespeare in Southern Africa Vol. 17 2005: pp.35-44. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  8. The Performance of Jaques | Voss | Shakespeare in Southern Africa

    African Journals Online (AJOL)

    No Abstract. Shakespeare in Southern Africa Vol. 19 2007: pp. 49-62. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  9. Shakespeare through the Looking-glass | Haresnape | Shakespeare ...

    African Journals Online (AJOL)

    ANONYMOUS: directed by Roland Emmerich (Columbia Pictures, 2011). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/sisa.v24i1.13 · AJOL African Journals Online. HOW TO ...

  10. Numerical Study of Wind Turbine Wake Modeling Based on a Actuator Surface Model

    DEFF Research Database (Denmark)

    Zhou, Huai-yang; Xu, Chang; Han, Xing Xing

    2017-01-01

    In the Actuator Surface Model (ALM), the turbine blades are represented by porous surfaces of velocity and pressure discontinuities to model the action of lifting surfaces on the flow. The numerical simulation is implemented on FLUENT platform combined with N-S equations. This model is improved o...

  11. The challenge of the social sciences: The impact of Sociology ...

    African Journals Online (AJOL)

    The challenge of the social sciences: The impact of Sociology among first year students. JF Graaff. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  12. The isometries of the cut, metric and hypermetric cones

    NARCIS (Netherlands)

    Deza, Antoine; Goldengorin, Boris; Pasechnik, Dmitrii V.

    2003-01-01

    We discuss integrated chance constraints in their role of short-term risk constraints in a strategic ALM model for Dutch pension funds. The problem is set up as a multistage recourse model, with special attention for modeling the guidelines proposed by the regulating authority for Dutch pension

  13. Genome-wide association study identified copy number variants important for appendicular lean mass.

    Science.gov (United States)

    Ran, Shu; Liu, Yong-Jun; Zhang, Lei; Pei, Yufang; Yang, Tie-Lin; Hai, Rong; Han, Ying-Ying; Lin, Yong; Tian, Qing; Deng, Hong-Wen

    2014-01-01

    Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM), is a heritable trait. Copy number variation (CNV) is a common type of human genome variant which may play an important role in the etiology of many human diseases. In this study, we performed genome-wide association analyses of CNV for ALM in 2,286 Caucasian subjects. We then replicated the major findings in 1,627 Chinese subjects. Two CNVs, CNV1191 and CNV2580, were detected to be associated with ALM (p = 2.26×10(-2) and 3.34×10(-3), respectively). In the Chinese replication sample, the two CNVs achieved p-values of 3.26×10(-2) and 0.107, respectively. CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1), which is important for skeletal muscle cell survival/death in humans. CNV2580 is located in the Serine hydrolase-like protein (SERHL) gene, which plays an important role in normal peroxisome function and skeletal muscle growth in response to mechanical stimuli. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in ALM.

  14. Genome-wide association study identified copy number variants important for appendicular lean mass.

    Directory of Open Access Journals (Sweden)

    Shu Ran

    Full Text Available Skeletal muscle is a major component of the human body. Age-related loss of muscle mass and function contributes to some public health problems such as sarcopenia and osteoporosis. Skeletal muscle, mainly composed of appendicular lean mass (ALM, is a heritable trait. Copy number variation (CNV is a common type of human genome variant which may play an important role in the etiology of many human diseases. In this study, we performed genome-wide association analyses of CNV for ALM in 2,286 Caucasian subjects. We then replicated the major findings in 1,627 Chinese subjects. Two CNVs, CNV1191 and CNV2580, were detected to be associated with ALM (p = 2.26×10(-2 and 3.34×10(-3, respectively. In the Chinese replication sample, the two CNVs achieved p-values of 3.26×10(-2 and 0.107, respectively. CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1, which is important for skeletal muscle cell survival/death in humans. CNV2580 is located in the Serine hydrolase-like protein (SERHL gene, which plays an important role in normal peroxisome function and skeletal muscle growth in response to mechanical stimuli. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in ALM.

  15. German Cultural Packets 13 and 14.

    Science.gov (United States)

    Atlanta Public Schools, GA.

    These German culture packets are designed to accompany A-LM Level II and include a statement of the rationale behind the unit, the objectives of the packet, the activities themselves, and a brief evaluation by the student. The activities involve the use of the basic text, the student workbook, corresponding tapes, and fellow students as partners…

  16. Serials use in a College of Agriculture Education Library | Adzobu ...

    African Journals Online (AJOL)

    Serials use in a College of Agriculture Education Library. J Adzobu, JA Opare. Abstract. No Abstract. Ghana Library Journal Vol. 20 (1) 2008: pp. 81-88. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM

  17. The cost-effectiveness of isotretinoin in the treatment of acne ...

    African Journals Online (AJOL)

    The cost-effectiveness of isotretinoin in the treatment of acne. François Wessels, A Nixon Anderson, Keith Kropman. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM.

  18. Access to and use of computers among clinical dental students of ...

    African Journals Online (AJOL)

    Access to and use of computers among clinical dental students of the University of Lagos. PO Ayanbadejo, OO Sofola, OG Uti. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Article Metrics. No metrics found. Metrics powered by PLOS ALM

  19. Alström syndrome is associated with short stature and reduced GH reserve.

    Science.gov (United States)

    Romano, S; Maffei, P; Bettini, V; Milan, G; Favaretto, F; Gardiman, M; Marshall, J D; Greggio, N A; Pozzan, G B; Collin, G B; Naggert, J K; Bronson, R; Vettor, R

    2013-10-01

    Alström syndrome (ALMS) is a rare autosomal recessive monogenic disease included in an emerging class of genetic disorders called 'ciliopathies' and is likely to impact the central nervous system as well as metabolic and endocrine function. Individuals with ALMS present clinical features resembling a growth hormone deficiency (GHD) condition, but thus far no study has specifically investigated this aspect in a large population. Twenty-three patients with ALMS (age, 1-52 years; 11 males, 12 females) were evaluated for anthropometric parameters (growth charts and standard deviation score (SDS) of height, weight, BMI), GH secretion by growth hormone-releasing hormone + arginine test (GHRH-arg), bone age, and hypothalamic-pituitary magnetic resonance imaging (MRI). A group of 17 healthy subjects served as controls in the GH secretion study. Longitudinal retrospective and prospective data were utilized. The length-for-age measurements from birth to 36 months showed normal growth with most values falling within -0·67 SDS to +1·28 SDS. A progressive decrease in stature-for-age was observed after 10 years of age, with a low final height in almost all ALMS subjects (>16-20 years; mean SDS, -2·22 ± 1·16). The subset of 12 patients with ALMS tested for GHRH-arg showed a significantly shorter stature than age-matched controls (154·7 ± 10·6 cm vs 162·9 ± 4·8 cm, P = 0·009) and a mild increase in BMI (Kg/m(2) ) (27·8 ± 4·8 vs 24·1 ± 2·5, P = 0·007). Peak GH after GHRH-arg was significantly lower in patients with ALMS in comparison with controls (11·9 ± 6·9 μg/l vs 86·1 ± 33·2 μg/l, P short stature reported in ALMS may be at least partially influenced by impairment of GH secretion. © 2013 John Wiley & Sons Ltd.

  20. Algal Supply System Design - Harmonized Version

    Energy Technology Data Exchange (ETDEWEB)

    Jared Abodeely; Daniel Stevens; Allison Ray; Debor

    2013-03-01

    The objective of this design report is to provide an assessment of current technologies used for production, dewatering, and converting microalgae cultivated in open-pond systems to biofuel. The original draft design was created in 2011 and has subsequently been brought into agreement with the DOE harmonized model. The design report extends beyond this harmonized model to discuss some of the challenges with assessing algal production systems, including the ability to (1) quickly assess alternative algal production system designs, (2) assess spatial and temporal variability, and (3) perform large-scale assessments considering multiple scenarios for thousands of potential sites. The Algae Logistics Model (ALM) was developed to address each of these limitations of current modeling efforts to enable assessment of the economic feasibility of algal production systems across the United States. The (ALM) enables (1) dynamic assessments using spatiotemporal conditions, (2) exploration of algal production system design configurations, (3) investigation of algal production system operating assumptions, and (4) trade-off assessments with technology decisions and operating assumptions. The report discusses results from the ALM, which is used to assess the baseline design determined by harmonization efforts between U.S. DOE national laboratories. Productivity and resource assessment data is provided by coupling the ALM with the Biomass Assessment Tool developed at PNNL. This high-fidelity data is dynamically passed to the ALM and used to help better understand the impacts of spatial and temporal constraints on algal production systems by providing a cost for producing extracted algal lipids annually for each potential site.

  1. Monitoring the Orientational Changes of Alamethicin during Incorporation into Bilayer Lipid Membranes.

    Science.gov (United States)

    Forbrig, Enrico; Staffa, Jana K; Salewski, Johannes; Mroginski, Maria Andrea; Hildebrandt, Peter; Kozuch, Jacek

    2018-02-13

    Antimicrobial peptides (AMPs) are the first line of defense after contact of an infectious invader, for example, bacterium or virus, with a host and an integral part of the innate immune system of humans. Their broad spectrum of biological functions ranges from cell membrane disruption over facilitation of chemotaxis to interaction with membrane-bound or intracellular receptors, thus providing novel strategies to overcome bacterial resistances. Especially, the clarification of the mechanisms and dynamics of AMP incorporation into bacterial membranes is of high interest, and different mechanistic models are still under discussion. In this work, we studied the incorporation of the peptaibol alamethicin (ALM) into tethered bilayer lipid membranes on electrodes in combination with surface-enhanced infrared absorption (SEIRA) spectroscopy. This approach allows monitoring the spontaneous and potential-induced ion channel formation of ALM in situ. The complex incorporation kinetics revealed a multistep mechanism that points to peptide-peptide interactions prior to penetrating the membrane and adopting the transmembrane configuration. On the basis of the anisotropy of the backbone amide I and II infrared absorptions determined by density functional theory calculations, we employed a mathematical model to evaluate ALM reorientations monitored by SEIRA spectroscopy. Accordingly, ALM was found to adopt inclination angles of ca. 69°-78° and 21° in its interfacially adsorbed and transmembrane incorporated states, respectively. These orientations can be stabilized efficiently by the dipolar interaction with lipid head groups or by the application of a potential gradient. The presented potential-controlled mechanistic study suggests an N-terminal integration of ALM into membranes as monomers or parallel oligomers to form ion channels composed of parallel-oriented helices, whereas antiparallel oligomers are barred from intrusion.

  2. Alfalfa leaf meal in beef steer receiving diets. Quarterly report, July 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Zehnder, C.M.; DiCostanzo, A.; Smith, L.B.

    1998-06-01

    Two trials were conducted to study the effects of alfalfa leaf meal (ALM) in receiving diets of steers. In trial one, ninety-six medium frame, Angus and Angus cross steer calves (average initial weight 500 lb) were allotted to a heavy or light weight block and then randomly assigned to one of four dietary treatments for a 29-day receiving trial. In trial two, sixty medium frame, Angus and Angus cross steer calves (average initial weight 518 lb) were allotted to one of ten dietary treatments. Trial two was divided into two periods, defined as a receiving period, 29 days, and a step-up period, 33 days. In trial one, treatments were control (supplemental soybean meal), alfalfa leaf meal (ALM) providing 33%, 66%, or 100% of supplemental protein; the balance was soybean meal. Receiving diets were formulated to contain .54 Mcal NE{sub g} /lb dry matter, 14% crude protein, .6 % Ca and .3 % P. In study two, treatments were control (supplemental soybean meal), ALM providing 33%, 66%7 100% of supplemental protein, the balance was soybean meal and urea or a blend of ALM and blood meal (93 % ALM and 7 % blood meal) to provide supplemental protein. Each protein treatment was fed in diets consisting of cracked or whole corn. Trial two receiving diets were formulated to contain .54 Mcal NE{sub g} /lb dry matter, 14% crude protein, .6 % Ca and .3 % P, step-up diets were formulated to contain .58 Mcal NE9 /lb dry matter, 11.3% crude protein, .6 % Ca and .3 % P.

  3. Marker Protein Expression Combined With Expression Heterogeneity is a Powerful Indicator of Malignancy in Acral Lentiginous Melanomas.

    Science.gov (United States)

    Cintra Lopes Carapeto, Fernando; Neves Comodo, Andréia; Germano, Andressa; Pereira Guimarães, Daiane; Barcelos, Denise; Fernandes, Mariana; Landman, Gilles

    2017-02-01

    Samples of acral lentiginous melanomas (ALMs) were obtained from the Department of Pathology at Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Demographic, clinical, and follow-up data were obtained from the charts of Hospital São Paulo. From 2 tissue microarrays containing 60 nevi and quadruplicate samples of ≥1.0-mm of 49 ALM, sections were stained to evaluate SCF, KIT, BRAF, CYCLIND1, MYC, and PTEN immunohistochemical protein expression. Nevi and ALM from 2006 to 2010 were reviewed and collected. All specimens were in the vertical growth phase, and histopathological parameters indicated that tumors were at an advanced stage at diagnosis. Average tumor thickness was 6.95 mm, 63% were ulcerated, average mitotic index was 5 mitotic cells per mm, and 43% were at Clark's level V. Compared with nevi, the χ test showed that ALM significantly correlated with SCF protein expression (P = 0.001) and expression heterogeneity (P < 0.000). Similar findings were observed for KIT (P = 0.005, P = 0.003, respectively), MYC (P < 0.000, P < 0.000), and PTEN (P = 0.005, P < 0.000). Malignancy did not correlate with BRAF and CYCLIN D1 expression (P = 0.053 and P = 0.259, respectively), but it did significantly correlate with their heterogeneous expression (P < 0.000, P = 0.024, respectively). Combined protein expression had an odds ratio of greater malignancy when BRAF and MYC were positive and/or heterogeneously expressed (OR of 78 and 95, respectively). We show that marker protein expression, when combined with heterogeneous expression as shown by immunohistochemistry, is a powerful indicator of malignancy in ALMs, especially, when protein pairs are combined.

  4. Produtos de pescado elaborados com resíduos de arrasto: análise físico-química, microbiológica e toxicológica

    Directory of Open Access Journals (Sweden)

    D.S. Ribeiro

    Full Text Available RESUMO Na pesca de arrasto, são inúmeras as espécies de peixe capturadas acidentalmente, compostas, em sua maioria, de espécimes de pequeno tamanho e baixo valor comercial, os quais recebem o nome de rejeito de pesca. O presente trabalho teve como objetivo o desenvolvimento de dois produtos, almôndega e quibe de peixe, tendo como matéria- prima espécies consideradas capturas acidentais na modalidade de pesca de arrasto realizada no litoral do Rio de Janeiro. A identificação taxonômica das espécies teve como resultado as espécies pargo (Pagrus pagrus, castanha (Umbrina sp., olho-de-cão (Priacanthus arenatus, congro-negro (Conger sp., congro-rosa (Genypterus brasiliensis e peixe-sapo (Lophius gastrophysus. A matéria seca percentual na polpa foi de 31,20±1,30%, no quibe e na almôndega crus; os valores foram de 37,90±1,10 e 32,10±1,10, respectivamente. Nos produtos assados, os resultados foram 33,40±1,20 para o quibe e 34,20±1,00 para a almôndega. Os teores de cinzas na polpa foram 1,5% para o quibe e a almôndega crus; os valores de cinzas foram de 2,55±0,05 e 1,47±0,05, respectivamente. Para os produtos assados, os resultados foram 1,87±0,05 para o quibe e 1,92±0,05 para a almôndega. Os teores de lipídeos aferidos na polpa foram de 4,80±0,30%. Com relação ao quibe e à almôndega crus, o percentual de lipídeos foi de 4,20±0,80 e 4,20±0,60, respectivamente. Para os produtos assados, foi de 4,50±0,60 para o quibe e 4,40±0,60 para a almôndega. A proteína bruta apresentou, na polpa, um índice de 15,60±1,04%. Com relação ao quibe e à almôndega crus, 17,80±2,16 e 14,90±2,12, respectivamente. Para os produtos assados, 15,10±2,10 em ambos. Os compostos nitrogenados solúveis, formadores do NNP, apresentaram valores de 285mg NNP/100g de polpa de pescado crua, 291mg NNP/100g no quibe cru e 294mg NNP/100g na almôndega crua. Os resultados da contagem total de psicrotróficos mantiveram-se abaixo de log 7,0UFC

  5. Effect of almond consumption on vascular function in patients with coronary artery disease: a randomized, controlled, cross-over trial.

    Science.gov (United States)

    Chen, C-Y Oliver; Holbrook, Monika; Duess, Mai-Ann; Dohadwala, Mustali M; Hamburg, Naomi M; Asztalos, Bela F; Milbury, Paul E; Blumberg, Jeffrey B; Vita, Joseph A

    2015-06-17

    Almonds reduce cardiovascular disease risk via cholesterol reduction, anti-inflammation, glucoregulation, and antioxidation. The objective of this randomized, controlled, cross-over trial was to determine whether the addition of 85 g almonds daily to a National Cholesterol Education Program (NCEP) Step 1 diet (ALM) for 6 weeks would improve vascular function and inflammation in patients with coronary artery disease (CAD). A randomized, controlled, crossover trial was conducted in Boston, MA to test whether as compared to a control NCEP Step 1 diet absent nuts (CON), incorporation of almonds (85 g/day) into the CON diet (ALM) would improve vascular function and inflammation. The study duration was 22 weeks including a 6-weeks run-in period, two 6-weeks intervention phases, and a 4-weeks washout period between the intervention phases. A total of 45 CAD patients (27 F/18 M, 45-77 y, BMI = 20-41 kg/m(2)) completed the study. Drug therapies used by patients were stable throughout the duration of the trial. The addition of almonds to the CON diet increased plasma α-tocopherol status by a mean of 5.8%, reflecting patient compliance (P ≤0.05). However, the ALM diet did not alter vascular function assessed by measures of flow-mediated dilation, peripheral arterial tonometry, and pulse wave velocity. Further, the ALM diet did not significantly modify the serum lipid profile, blood pressure, C-reactive protein, tumor necrosis factor-α or E-selectin. The ALM diet tended to decrease vascular cell adhesion molecule-1 by 5.3% (P = 0.064) and increase urinary nitric oxide by 17.5% (P = 0.112). The ALM intervention improved the overall quality of the diet by increasing calcium, magnesium, choline, and fiber intakes above the Estimated Average Requirement (EAR) or Recommended Dietary Allowance (RDA). Thus, the addition of almonds to a NECP Step 1 diet did not significantly impact vascular function, lipid profile or systematic inflammation in CAD patients receiving

  6. Field Test of Boiler Primary Loop Temperature Controller

    Energy Technology Data Exchange (ETDEWEB)

    Glanville, P. [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Rowley, P. [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Schroeder, D. [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States); Brand, L. [Partnership for Advanced Residential Retrofit, Des Plaines, IL (United States)

    2014-09-01

    Beyond these initial system efficiency upgrades are an emerging class of Advanced Load Monitoring (ALM) aftermarket controllers that dynamically respond to the boiler load, with claims of 10% to 30% of fuel savings over a heating season. For hydronic boilers specifically, these devices perform load monitoring, with continuous measurement of supply and, in some cases, return water temperatures. Energy savings from these ALM controllers are derived from dynamic management of the boiler differential, where a microprocessor with memory of past boiler cycles prevents the boiler from firing for a period of time, to limit cycling losses and inefficient operation during perceived low load conditions. These differ from OTR controllers, which vary boiler setpoint temperatures with ambient conditions while maintaining a fixed differential.

  7. Logic For Qualification And Industrialisation Of Additive Layer Manufacturing Parts For Spatial Application

    Science.gov (United States)

    Brindeau, Aymeric; Lopes, Jean-Louis; Brivot, Frederic; Bourneaud, Florent; Desagulier, Christian

    2012-07-01

    ASTRIUM Space Transportation has been manufacturing composite equipments for satellite for 25 years. For this business, the development of Additive Layer Manufacturing (ALM) processes has been identified as a real opportunity to improve design and performances. For satellite equipments, ASTRIUM ST has chosen to investigate in the Electron Beam Melting process (patented EBM® process from Arcam AB company) for the manufacturing of Titanium parts, in collaboration with MECACHROME who has developed strong skills in this ALM process. This first development step has been achieved by introducing a titanium part realised by EBM on an equipment of Atlantic Bird 7 satellite launched in September 2011. The new step consists in the formal industrialisation of the EBM process for the procurement of titanium parts for satellite equipments. The present paper describes the logic retained for this industrialisation. It includes the technical requirements but also the verifications and inspections which have to be performed to guarantee that technical requirements are met.

  8. Measurement of fracture toughness of metallic materials produced by additive manufacturing

    Science.gov (United States)

    Quénard, O.; Dorival, O.; Guy, Ph.; Votié, A.; Brethome, K.

    2018-04-01

    This study focuses on the microstructure and mechanical properties of metallic materials produced by additive layer manufacturing (ALM), especially the laser beam melting process. The influence of the specimen orientation during the ALM process and that of two post-build thermal treatments were investigated. The identified metal powder is Ti-6Al-4V (titanium base). Metallographic analysis shows their effects on the microstructure of the metals. Mechanical experiments involving tensile tests as well as toughness tests were performed according to ASTM (American Society for Testing and Materials) norms. The results show that the main influence is that of the thermal treatments; however the manufacturing stacking direction may lead to some anisotropy in the mechanical properties.

  9. Tip vortices in the actuator line model

    Science.gov (United States)

    Martinez, Luis; Meneveau, Charles

    2017-11-01

    The actuator line model (ALM) is a widely used tool to represent the wind turbine blades in computational fluid dynamics without the need to resolve the full geometry of the blades. The ALM can be optimized to represent the `correct' aerodynamics of the blades by choosing an appropriate smearing length scale ɛ. This appropriate length scale creates a tip vortex which induces a downwash near the tip of the blade. A theoretical frame-work is used to establish a solution to the induced velocity created by a tip vortex as a function of the smearing length scale ɛ. A correction is presented which allows the use of a non-optimal smearing length scale but still provides the downwash which would be induced using the optimal length scale. Thanks to the National Science Foundation (NSF) who provided financial support for this research via Grants IGERT 0801471, IIA-1243482 (the WINDINSPIRE project) and ECCS-1230788.

  10. Collagen reconstitution is inversely correlated with induction of limb regeneration in Ambystoma mexicanum.

    Science.gov (United States)

    Satoh, Akira; Hirata, Ayako; Makanae, Aki

    2012-03-01

    Amphibians can regenerate missing body parts, including limbs. The regulation of collagen has been considered to be important in limb regeneration. Collagen deposition is suppressed during limb regeneration, so we investigated collagen deposition and apical epithelial cap (AEC) formation during axolotl limb regeneration. The accessory limb model (ALM) has been developed as an alternative model for studying limb regeneration. Using this model, we investigated the relationship between nerves, epidermis, and collagen deposition. We found that Sp-9, an AEC marker gene, was upregulated by direct interaction between nerves and epidermis. However, collagen deposition hindered this interaction, and resulted in the failure of limb regeneration. During wound healing, an increase in deposition of collagen caused a decrease in the blastema induction rate in ALM. Wound healing and limb regeneration are alternate processes.

  11. Sequential Acral Lentiginous Melanomas of the Foot

    Directory of Open Access Journals (Sweden)

    Jiro Uehara

    2010-12-01

    Full Text Available A 64-year-old Japanese woman had a lightly brown-blackish pigmented macule (1.2 cm in diameter on the left sole of her foot. She received surgical excision following a diagnosis of acral lentiginous melanoma (ALM, which was confirmed histopathologically. One month after the operation, a second melanoma lesion was noticed adjacent to the grafted site. Histopathologically, the two lesions had no continuity, but HMB-45 and cyclin D1 double-positive cells were detected not only on aggregates of atypical melanocytes but also on single cells near the cutting edge of the first lesion. The unique occurrence of a sequential lesion of a primary melanoma might be caused by stimulated subclinical field cells during the wound healing process following the initial operation. This case warrants further investigation to establish the appropriate surgical margin of ALM lesions.

  12. Simulation of a 7.7 MW onshore wind farm with the Actuator Line Model

    Science.gov (United States)

    Guggeri, A.; Draper, M.; Usera, G.

    2017-05-01

    Recently, the Actuator Line Model (ALM) has been evaluated with coarser resolution and larger time steps than what is generally recommended, taking into account an atmospheric sheared and turbulent inflow condition. The aim of the present paper is to continue these studies, assessing the capability of the ALM to represent the wind turbines’ interactions in an onshore wind farm. The ‘Libertad’ wind farm, which consists of four 1.9MW Vestas V100 wind turbines, was simulated considering different wind directions, and the results were compared with the wind farm SCADA data, finding good agreement between them. A sensitivity analysis was performed to evaluate the influence of the spatial resolution, finding acceptable agreement, although some differences were found. It is believed that these differences are due to the characteristics of the different Atmospheric Boundary Layer (ABL) simulations taken as inflow condition (precursor simulations).

  13. Acral lentiginous melanoma of the foot and ankle: A case series and review of the literature

    Directory of Open Access Journals (Sweden)

    Acland Katharine

    2008-09-01

    Full Text Available Abstract Background Acral lentiginous melanoma (ALM is an uncommon, cutaneous malignant tumour which may arise on the foot. Its relative rarity, atypical appearance and late presentation frequently serve as poor prognostic indicators. Methods At a tertiary skin tumour centre, a retrospective review was undertaken of all patients diagnosed with the tumour at the level of ankle or below. Results Over a six year period, 27 cases (20 female, 7 male were identified with positive histology confirming the disease. The age ranged from 35–96 years of age (mean 62.7 years. The majority of the cohort were white (59% with plantar lesions (62%. 33% of patients were initially were diagnosed incorrectly. The average time taken from the point of recognition, by the patient, to the lesion being correctly diagnosed was around 13.5 months. Conclusion Earlier diagnosis of ALM requires education at both a patient and practitioner level.

  14. Finance & Stochastic

    OpenAIRE

    Giandomenico, Rossano

    2014-01-01

    The study analyses quantitative models for financial markets by starting from geometric Brown process and Wiener process by analyzing Ito’s lemma and first passage model. Furthermore, it is analyzed the prices of the options, Vanilla & Exotic, by using the expected value and numerical model with geometric applications. From contingent claim approach ALM strategies are also analyzed so to get the effective duration measure of liabilities by assuming that clients buy options for protection and ...

  15. Music education in Malawi | Chanunkha | Journal of Humanities

    African Journals Online (AJOL)

    Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/jh.v16i1.6298 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · FAQ's · News · AJOL jobs · More about ...

  16. United States Air Force Summer Research Program 1991. Volume 1. Program Management Report

    Science.gov (United States)

    1992-01-09

    Engineering 4 4 Aerospace Engineering 3 16 19 Aerospace Mechanics 2 2 Astronomy 1 1 Astrophysics 2 2 Biochemistry 1 I Bioengineering 1 1 Biological...27706 C-1 NAME/ADDRESS DEGREE, SPECIALTY, LAB ASSIGNMENT David W. Barnett DEGREE: PhD Asst Professor SPECIALTY: Physical Sciences Dept of KinesioLogy LAB...SPECIALTY: Exercise Physiology Dept of KinesioLogy LAB ASSIGNMENT: SAN Baton Rouge, LA 70803 Amie L. edLtey-Goode DEGREE: NS Texas ALM University

  17. Coinjection with CpG-Containing Immunostimulatory Oligodeoxynucleotides Reduces the Pathogenicity of a Live Vaccine against Cutaneous Leishmaniasis but Maintains Its Potency and Durability

    Science.gov (United States)

    Mendez, Susana; Tabbara, Khaled; Belkaid, Yasmine; Bertholet, Sylvie; Verthelyi, Daniela; Klinman, Dennis; Seder, Robert A.; Sacks, David L.

    2003-01-01

    The inoculation of live, nonattenuated Leishmania major to produce a lesion in a selected site that heals, referred to as leishmanization, is to date the only vaccine against leishmaniasis that has proven to be effective in humans. Its use has been restricted or abandoned entirely, however, due to safety concerns. In an attempt to develop a leishmanization protocol that minimizes pathology while maintaining long-term protection, live parasites were coinjected with CpG-containing immunostimulatory oligodeoxynucleotides (CpG ODNs) alone or in combination with whole-cell lysates of heat-killed L. major promastigotes bound to alum (ALM). C57BL/6 mice infected intradermally by using L. major plus CpG ODN with or without ALM developed few or no dermal lesions and showed an early containment of parasite growth, while mice infected with L. major with or without ALM developed sizable dermal lesions that required up to 10 weeks to heal. The CpG ODNs provoked a transient inflammation that included an early recruitment and accumulation of gamma interferon-producing CD4+ lymphocytes in the site. Attenuation of the live vaccine did not compromise its ability to confer long-term immunity, as mice receiving L. major and CpG ODN plus ALM were totally protected against reinfection with L. major for up to 6 months. By comparison, the immunity elicited by two efficient nonlive vaccines began to wane by 6 months. Our results suggest that immune modulation using CpG ODNs might be a practical approach to improving the safety of a highly effective live vaccine that has already been widely applied. PMID:12933855

  18. Coenzyme Q10: A New Treatment for Hemorrhagic Shock

    Science.gov (United States)

    2014-10-29

    SUBJECT TERMS hemorrhagic shock, ubiquinol, Coenzyme Q10, patient outcome 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18...o leo& to tboOigllll failure. The < Iota fur AlM •1 ha"’ boon ._...runym.,..,; •• ted in p=en~atlons and publiobed tn Expu""’""" P/u<llology. Tho

  19. Enterprise Clusters in Kenya | McCormick | Africa Insight

    African Journals Online (AJOL)

    Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/ai.v31i1.22347 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · FAQ's · News · AJOL jobs · More about ...

  20. Paraguay - Real Property Tax : Key to Fiscal Decentralization and Better Land Use, Volume 2. Technical Anneses

    OpenAIRE

    World Bank

    2007-01-01

    This study has at its origin the land question in Paraguay, namely that land ownership is highly concentrated and has become a source of social conflict in the rural areas where one-half of the population lives. A central thesis of the study is that the existing patterns of land use and ownership, in particular, the very large land holdings (Zatifundio), are a reflection in part of the alm...

  1. Development of an accelerated leaching method for incineration bottom ash correlated to toxicity characteristic leaching protocol.

    Science.gov (United States)

    Lin, Shengxuan; Zhou, Xuedong; Ge, Liya; Ng, Sum Huan; Zhou, Xiaodong; Chang, Victor Wei-Chung

    2016-10-01

    Heavy metals and some metalloids are the most significant inorganic contaminants specified in toxicity characteristic leaching procedure (TCLP) in determining the safety of landfills or further utilization. As a consequence, a great deal of efforts had been made on the development of miniaturized analytical devices, such as Microchip Electrophoresis (ME) and μTAS for on-site testing of heavy metals and metalloids to prevent spreading of those pollutants or decrease the reutilization period of waste materials such as incineration bottom ash. However, the bottleneck lied in the long and tedious conventional TCLP that requires 18 h of leaching. Without accelerating the TCLP process, the on-site testing of the waste material leachates was impossible. In this study, therefore, a new accelerated leaching method (ALM) combining ultrasonic assisted leaching with tumbling was developed to reduce the total leaching time from 18 h to 30 min. After leaching, the concentrations of heavy metals and metalloids were determined with ICP-MS or ICP-optical emission spectroscopy. No statistical significance between ALM and TCLP was observed for most heavy metals (i.e., cobalt, manganese, mercury, molybdenum, nickel, silver, strontium, and tin) and metalloids (i.e., arsenic and selenium). For the heavy metals with statistical significance, correlation factors derived between ALM and TCLP were 0.56, 0.20, 0.037, and 0.019 for barium, cadmium, chromium, and lead, respectively. Combined with appropriate analytical techniques (e.g., ME), the ALM can be applied to rapidly prepare the incineration bottom ash samples as well as other environmental samples for on-site determination of heavy metals and metalloids. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Differentiation of Uterine Leiomyosarcoma from Atypical Leiomyoma: Diagnostic Accuracy of Qualitative MR Imaging Features and Feasibility of Texture Analysis.

    Science.gov (United States)

    Lakhman, Yulia; Veeraraghavan, Harini; Chaim, Joshua; Feier, Diana; Goldman, Debra A; Moskowitz, Chaya S; Nougaret, Stephanie; Sosa, Ramon E; Vargas, Hebert Alberto; Soslow, Robert A; Abu-Rustum, Nadeem R; Hricak, Hedvig; Sala, Evis

    2017-07-01

    To investigate whether qualitative magnetic resonance (MR) features can distinguish leiomyosarcoma (LMS) from atypical leiomyoma (ALM) and assess the feasibility of texture analysis (TA). This retrospective study included 41 women (ALM = 22, LMS = 19) imaged with MRI prior to surgery. Two readers (R1, R2) evaluated each lesion for qualitative MR features. Associations between MR features and LMS were evaluated with Fisher's exact test. Accuracy measures were calculated for the four most significant features. TA was performed for 24 patients (ALM = 14, LMS = 10) with uniform imaging following lesion segmentation on axial T2-weighted images. Texture features were pre-selected using Wilcoxon signed-rank test with Bonferroni correction and analyzed with unsupervised clustering to separate LMS from ALM. Four qualitative MR features most strongly associated with LMS were nodular borders, haemorrhage, "T2 dark" area(s), and central unenhanced area(s) (p ≤ 0.0001 each feature/reader). The highest sensitivity [1.00 (95%CI:0.82-1.00)/0.95 (95%CI: 0.74-1.00)] and specificity [0.95 (95%CI:0.77-1.00)/1.00 (95%CI:0.85-1.00)] were achieved for R1/R2, respectively, when a lesion had ≥3 of these four features. Sixteen texture features differed significantly between LMS and ALM (p-values: feasible. • Four qualitative MR features demonstrated the strongest statistical association with LMS. • Combination of ≥3 these features could accurately differentiate LMS from ALM. • Texture analysis was a feasible semi-automated approach for lesion categorization.

  3. Separately contacted edge states: A new spectroscopic tool for the investigation of the quantum Hall effect

    OpenAIRE

    Wuertz, A.; Wildfeuer, R.; Lorke, A.; Deviatov, E. V.; Dolgopolov, V. T.

    2001-01-01

    Using an innovative combination of a quasi-Corbino sample geometry and the cross-gate technique, we have developed a method that enables us to separately contact single edge channels in the quantum Hall regime and investigate equilibration among them. Performing 4-point resistance measurements, we directly obtain information on the energetic and geometric structure of the edge region and the equilibration-length for current transport across the Landau- as well as the spin-gap. Based on an alm...

  4. In vivo characterization of insulin uptake by dog renal cortical epithelium

    International Nuclear Information System (INIS)

    Whiteside, C.I.; Lumsden, C.J.; Silverman, M.

    1988-01-01

    In vivo 125I-labeled insulin uptake by dog renal tubular epithelium was studied using the single-pass multiple indicator dilution (MID) method and analyzed by a computer-assisted model of transcapillary exchange and substrate-cell interaction. Anesthetized dogs received an intrarenal arterial bolus of multiple tracers: [3H]dextran greater than 70 kDa (plasma reference), [14C]inulin (extracellular reference), and 125I-insulin. Rapid serial sampling of the renal venous and urine outflows was performed. The renal venous outflow curves of 125I-insulin fell below [14C]inulin implying postglomerular extraction and antiluminal membrane (ALM) uptake. The fractional urine recovery of 125I-insulin was less than 0.03, indicating luminal tubular uptake of filtered hormone. After intravenous infusion of unlabeled insulin, repeat MID runs with tracer revealed saturable ALM uptake as evidenced by the 125I-insulin renal venous outflow curves approaching [14C]inulin. Luminal tubular uptake was unchanged and therefore unsaturable. The 125I-insulin renal venous data were studied using three mathematical models, incorporating postglomerular reversible binding, irreversible binding or transport. The best fit was obtained using the transport model. The modeling analysis is consistent with either uptake into a virtual epithelial membrane space (i.e., insulin never enters the cell but binds to or is distributed along the ALM) or insulin actually enters the intracellular compartment. In vivo uptake of 125I-insulin ALM is characterized by a Km of 15.44 nM

  5. Mutations in Alström Protein Impair Terminal Differentiation of Cardiomyocytes

    OpenAIRE

    Shenje, Lincoln T.; Andersen, Peter; Halushka, Marc K.; Lui, Cecillia; Fernandez, Laviel; Collin, Gayle B.; Amat-Alarcon, Nuria; Meschino, Wendy; Cutz, Ernest; Chang, Kenneth; Yonescu, Raluca; Batista, Denise A. S.; Chen, Yan; Chelko, Stephen; Crosson, Jane E.

    2014-01-01

    Cardiomyocyte cell division and replication in mammals proceed through embryonic development and abruptly decline soon after birth. The process governing cardiomyocyte cell cycle arrest is poorly understood. Here we carry out whole exome sequencing in an infant with evidence of persistent postnatal cardiomyocyte replication to determine the genetic risk factors. We identify compound heterozygous ALMS1 mutations in the proband, and confirm their presence in her affected sibling, one copy inher...

  6. In vitro antagonistic activity, plant growth promoting traits and phylogenetic affiliation of rhizobacteria associated with wild plants grown in arid soil

    OpenAIRE

    El-Sayed, Wael S.; Akhkha, Abdellah; El-Naggar, Moustafa Y.; Elbadry, Medhat

    2014-01-01

    The role of plant growth-promoting rhizobacteria (PGPR) in adaptation of plants in extreme environments is not yet completely understood. For this study native bacteria were isolated from rhizospeheric arid soils and evaluated for both growth-promoting abilities and antagonistic potential against phytopathogenic fungi and nematodes. The phylogentic affiliation of these representative isolates was also characterized. Rhizobacteria associated with 11 wild plant species from the arid soil of Alm...

  7. Association of protein intake with the change of lean mass among elderly women: The Osteoporosis Risk Factor and Prevention - Fracture Prevention Study (OSTPRE-FPS).

    Science.gov (United States)

    Isanejad, Masoud; Mursu, Jaakko; Sirola, Joonas; Kröger, Heikki; Rikkonen, Toni; Tuppurainen, Marjo; Erkkilä, Arja T

    2015-01-01

    Low protein intake can lead to declined lean mass (LM) in elderly. We examined the associations of total protein (TP), animal protein (AP) and plant protein (PP) intakes with LM. The association of TP intake with LM change was further evaluated according to weight change status. This cross-sectional and prospective cohort study included 554 women aged 68 (sd 1·9) years from the Osteoporosis Risk Factor and Prevention - Fracture Prevention Study (OSTPRE-FPS). The intervention group (n 270) received daily cholecalciferol (800 IU; 20 μg) and Ca (1000 mg) for 3 years while the control group received neither supplementation nor placebo (n 282). Participants filled out a questionnaire on lifestyle factors and a 3-d food record in 2002 and underwent dual-energy X-ray absorptiometry for body composition measurements at baseline and 3 years. Multiple linear regressions evaluated the association between protein intake and LM, adjusting for relevant covariates. At the baseline TP and AP intakes were positively associated with LM and trunk LM, TP was associated also with appendicular LM (aLM). Follow-up results showed that in the total population and the intervention group, higher TP and AP were associated with increased LM and aLM (P ≤ 0·050). No such associations were observed in the control group. PP intake was also associated with aLM change in the total population. Overall, the associations were independent of fat mass. Further, among weight maintainers, TP intake was positively associated with LM, aLM and trunk LM changes (P ≤ 0·020). In conclusion, dietary TP, especially AP, intake may be a modifiable risk factor for sarcopenia by preserving LM in the elderly.

  8. Semiannual Report to the Congress, October 1, 2011 - March 31, 2012

    Science.gov (United States)

    2012-03-31

    0013-ALM Follow-up Audit of Rotor Blades 11/08/2011 USAAA A-2012-0015- FFM Controls Over the Incentive Program in the Indiana Army National Guard...Financial Statements 11/02/2011 USAAA A-2012-0022- FFM Army Executive Dining Facility Fund Financial Statements, Office of the Administrative Assistant to...the Secretary of the Army 12/06/2011 USAAA A-2012-0023- FFM Army Executive Dining Facility Fund Internal Controls, Office of the Administrative

  9. Ecology and Population Structure of Vibrionaceae in the Coastal Ocean

    Science.gov (United States)

    2010-02-01

    mussels filter water (containing zooplankton) and crabs preferentially consume mussels but have alternative food sources. The blue background color...clonal expansion, was especially pronounced in crab and zooplankton samples. Specialization, demonstrated by specific and reproducible association with...Martin deserves credit for cultivating a creative and collaborative lab environment. I’m very grateful to Eric Alm for all of his help. Eric has been an

  10. Public Interest in Accessing the INIS Collection

    OpenAIRE

    Savić, Dobrica (IAEA-NIS); GreyNet, Grey Literature Network Service

    2016-01-01

    Since its creation in 1970, the International Nuclear Information System (INIS) has collected and provided access to more than 3.8 million bibliographic references to publications, documents, technical reports, non-copyrighted documentation, and other grey literature, as well as over a million full texts. Overall, there are 800 GB of data in the INIS repository. Public interest in accessing this collection has been remarkable. This year alone, there were more than one million sessions and alm...

  11. Editorial : Emerging issues of measles | Obimbo | East African ...

    African Journals Online (AJOL)

    Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/eamj.v78i1.9102 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · FAQ's · News · AJOL jobs · More about ...

  12. Polypharmacy as a Risk Factor for Clinically Relevant Sarcopenia: Results From the Berlin Aging Study II.

    Science.gov (United States)

    König, Maximilian; Spira, Dominik; Demuth, Ilja; Steinhagen-Thiessen, Elisabeth; Norman, Kristina

    2017-12-12

    Sarcopenia affects more than 10% of older adults. Next to age-associated physiologic changes, diseases like diabetes or inflammatory, neurological, malignant and endocrine disorders may contribute to the development of sarcopenia. Likewise, polypharmacy, i.e., multiple drug use, is common among older adults. Although the two conditions frequently co-occur, the association of polypharmacy with sarcopenia has not yet been examined. We investigated the association of polypharmacy and sarcopenia in a large cohort of community-dwelling older adults (60-84 years). Thousand five hundred and two participants from the Berlin Aging Study II were included. Polypharmacy was defined as concurrent use of 5 or more drugs (prescription and nonprescription). Body composition was assessed with dual-energy X-ray absorptiometry, and appendicular lean mass (ALM) was calculated as sum of the four limbs' lean mass. Sarcopenia was defined as low ALM-to-body mass index (BMI)-ratio using validated sex-specific cutoffs. Mean age was 68.7 ± 3.7 years, 50.7% were female. The median (interquartile range) number of drugs was 2 (1-4); 21.1% of subjects reported regular use of ≥5 drugs. Subjects with polypharmacy were more often sarcopenic according to the applied ALM/BMI-cutoffs (16.3% vs 6.9%, p sarcopenia (odds ratio = 2.24, 95% confidence interval [CI] = 1.33-3.75). Polypharmacy is associated with clinically relevant sarcopenia, as assessed by a low ALM/BMI. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Large fibroadenoma mimicking malignancy | Smal | SA Journal of ...

    African Journals Online (AJOL)

    Metrics powered by PLOS ALM · http://dx.doi.org/10.4102/sajr.v8i1.144 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · FAQ's · News · AJOL jobs · More about ...

  14. Comparative transcriptomic analysis of two Brassica napus near-isogenic lines reveals a network of genes that influences seed oil accumulation

    Directory of Open Access Journals (Sweden)

    Jingxue Wang

    2016-09-01

    Full Text Available Rapeseed (Brassica napus is an important oil seed crop, providing more than 13% of the world’s supply of edible oils. An in-depth knowledge of the gene network involved in biosynthesis and accumulation of seed oil is critical for the improvement of B. napus. Using available genomic and transcriptomic resources, we identified 1,750 acyl lipid metabolism (ALM genes that are distributed over 19 chromosomes in the B. napus genome. B. rapa and B. oleracea, two diploid progenitors of B. napus, contributed almost equally to the ALM genes. Genome collinearity analysis demonstrated that the majority of the ALM genes have arisen due to genome duplication or segmental duplication events. In addition, we profiled the expression patterns of the ALM genes in four different developmental stages. Furthermore, we developed two B. napus near isogenic lines (NILs. The high oil NIL, YC13-559, accumulates more than 10% of seed oil compared to the other, YC13-554. Comparative gene expression analysis revealed upregulation of lipid biosynthesis-related regulatory genes in YC13-559, including SHOOTMERISTEMLESS, LEAFY COTYLEDON 1 (LEC1, LEC2, FUSCA3, ABSCISIC ACID INSENSITIVE 3 (ABI3, ABI4, ABI5, and WRINKLED1, as well as structural genes, such as ACETYL-CoA CARBOXYLASE, ACYL-CoA DIACYLGLYCEROL ACYLTRANSFERASE, and LONG-CHAIN ACYL-CoA SYNTHETASES. We observed that several genes related to the phytohormones, gibberellins, jasmonate, and indole acetic acid, were differentially expressed in the NILs. Our findings provide a broad account of the numbers, distribution, and expression profiles of acyl lipid metabolism genes, as well as gene networks that potentially control oil accumulation in B. napus seeds. The upregulation of key regulatory and structural genes related to lipid biosynthesis likely plays a major role for the increased seed oil in YC13-559.

  15. INTERBANK DEPOSIT MARKET RELEVANCE FOR CROATIAN BANKING SYSTEM SUSTAINABILITY

    OpenAIRE

    Ercegovac, Roberto; Kundid, Ana

    2011-01-01

    Existence, functionality and sustainability of the interbank deposit market signifi cantly determinate bank’s asset and liability management (ALM) potentials and thus an overall banking sector performance. Among other numerous factors in the banking business, key roles of the interbank deposit market like availability of short-term liquidity sources, ensuring investment and lending opportunities as well as allowing hedging potentials, considerably contribute to commercial bank’s risk – return...

  16. Antagonistas a Phytophthora capsici inoculados en sustratos de germinación de Capsicum annuum Leonian y Mucuna deeringiana Bort.

    Directory of Open Access Journals (Sweden)

    Juliana Bautista-Calles

    2014-01-01

    Full Text Available Existen microorganismos benéficos a las plantas que se emplean de manera específica y aislada para favorecer la germinación y crecimiento. El beneficio es mayor si, en lugar de inocular un microorganismo específico al sustrato, se inoculan grupos de éstos para que disminuyan la incidencia de las enfermedades inducidas por fitopatógenos de la raíz; y, a su vez, favorezcan la emergencia y crecimiento de los cultivos. El objetivo de este trabajo, con enfoque holístico, fue evaluar las variables emergencia y altura de plántulas en almácigo, e incidencia en el invernadero al reintroducir antagonistas a Phytophthora capsici en grupos de 8, 16, 24 y 32 aislamientos de microorganismos, en los sustratos de germinación del chile (Capsicum annuum y frijol terciopelo (Mucuna deeringiana. Los tratamientos con grupos de antagonistas presentaron al menos uno de los efectos benéficos esperados (en comparación con el testigo, al incrementar la emergencia, la mayor altura de plántulas en el almácigo, y la menor incidencia por P. capsici en el invernadero. Los tratamientos que presentaron la mayor altura de plántulas en almácigo, fueron los tratamientos con grupos de 18, 24 y 32 antagonistas, que incluyeron el grupo de ocho actinomicetos. El mejor tratamiento fue con ocho aislamientos de actinomicetos, que presentó la mayor emergencia de plántulas para ambos cultivos en el almácigo y la menor incidencia de P. capsici en el cultivo de chile en invernadero.

  17. Editorial We're all affected by globalisation | le Roux | Africa Insight

    African Journals Online (AJOL)

    Editorial We're all affected by globalisation. Elizabeth le Roux. Abstract. No Abstract. Africa Insight Vol. 35(3) 2005: 2. Article Metrics. Metrics Loading ... Metrics powered by PLOS ALM · http://dx.doi.org/10.4314/ai.v35i3.22438 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors.

  18. Author Details

    African Journals Online (AJOL)

    Mosbah, Asma. Vol 20 (2009) - Articles Comportement à la corrosion intrinsèque de couches minces à base d'aluminium (Al-M: M=Mo, Mg, Y et Gd) obtenues par co-pulvérisation cathodique magnétron. Abstract PDF. ISSN: 2352-9717. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  19. Alfalfa leaf meal in wintering beef cow diets. Quarterly report, July 1, 1997--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Zehnder, C.M.; Hall, J.M.; Brown, D.B.; DiCostanzo, A.

    1998-06-01

    One hundred dry pregnant cows (1389 lb) and twenty-four pregnant heifers (1034 lb) were assigned by calving date and body condition to one of four dietary treatments for a wintering period during their late gestation. Dietary treatments consisted of supplementing crude protein (CP) at 100 % or 120 % of the recommended intake using either soybean meal or alfalfa leaf meal (ALM) as the supplemental protein source. Cows were group fed (two replicate pens/treatment) while heifers were individually fed for the duration of the study. The study lasted 70 (early) or 85 (late) days for cows and ended when the first cow in each replicate calved. For heifers, the study lasted for 100 days and ended accordingly when each heifer calved. Heifers fed ALM had consumed less (P < .05) hay and corn dry matter (DM). Overall diet DM intakes were unaffected (P > .05) by protein source. Feeding 120 % of recommended protein (2.38 vs 2.07 lb/day) to heifers increased (P < .05) their rate of gain by almost .5 lb/head/day. Cows fed ALM had faster (P < .05) rates of gain when gain was measured 22 days before calving. Once cows calved, weight change was similar (P > .05) for each protein source. However, cows fed alfalfa leaf meal consumed more (P = .054) total dry matter (DM). Calving traits were not affected by protein source or intake. Wintering heifers or cows on ALM-based supplements had no detrimental effect on performance of heifers or cows or their calves at birth. Additional protein may be required by heifers to ensure that they continue gaining weight during late gestation.

  20. Transforming Warrant Officer Career College Instructor Assessment for the Army Learning Model

    Science.gov (United States)

    2014-09-01

    Career College (WOCC) to reflect the Army Learning Model (ALM)’s emphasis on adult pedagogical approaches. An instructor guide was also developed to...and digital communications, building of effective relationships through interpersonal tact, influence, and communication. • Critical thinking and...students to learn. Foster respect and rapport in the instructor-student relationship and the student-student relationship . Encourage student

  1. Area Handbook Series. Sri Lanka, A Country Study

    Science.gov (United States)

    1988-10-01

    power- ful Indian monarch, Asoka , nurtured the new comprehensive religio-philosophical system in the third century B.C. Asoka’s con- version to...right collarbone and his revered alms bowl from Asoka and to have built the Thuparama Dagoba, or stupa (Buddhist shrine), to honor these highly revered...Association. The state has similarly retained close ties with the sangha. Since the time of Asoka , the first great Indian emperor (third century B.C.), the

  2. Predicting heat stress index in Sasso hens using automatic linear modeling and artificial neural network

    Science.gov (United States)

    Yakubu, A.; Oluremi, O. I. A.; Ekpo, E. I.

    2018-03-01

    There is an increasing use of robust analytical algorithms in the prediction of heat stress. The present investigation therefore, was carried out to forecast heat stress index (HSI) in Sasso laying hens. One hundred and sixty seven records on the thermo-physiological parameters of the birds were utilized. They were reared on deep litter and battery cage systems. Data were collected when the birds were 42- and 52-week of age. The independent variables fitted were housing system, age of birds, rectal temperature (RT), pulse rate (PR), and respiratory rate (RR). The response variable was HSI. Data were analyzed using automatic linear modeling (ALM) and artificial neural network (ANN) procedures. The ALM model building method involved Forward Stepwise using the F Statistic criterion. As regards ANN, multilayer perceptron (MLP) with back-propagation network was used. The ANN network was trained with 90% of the data set while 10% were dedicated to testing for model validation. RR and PR were the two parameters of utmost importance in the prediction of HSI. However, the fractional importance of RR was higher than that of PR in both ALM (0.947 versus 0.053) and ANN (0.677 versus 0.274) models. The two models also predicted HSI effectively with high degree of accuracy [r = 0.980, R 2 = 0.961, adjusted R 2 = 0.961, and RMSE = 0.05168 (ALM); r = 0.983, R 2 = 0.966; adjusted R 2 = 0.966, and RMSE = 0.04806 (ANN)]. The present information may be exploited in the development of a heat stress chart based largely on RR. This may aid detection of thermal discomfort in a poultry house under tropical and subtropical conditions.

  3. Las habas en el ajuar funerario de El Rincón de Almendricos (Lorca, Murcia

    Directory of Open Access Journals (Sweden)

    María Manuela AYALA JUAN

    2009-10-01

    Full Text Available El yacimiento de El Rincón, situado al N. O. de la población de Almendricos, Lorca, al Sur de la Región Murciana colindando con la Andaluza —desde lo cerros meridionales— de la Sierra de Enmedio próximos al yacimiento, se puede observar perfectamente el cerro de El Oficio-poblado argárico Alménense.

  4. Social theory and the region: from the Regional Planning Association of America to the restructuring of sociospatial theory, with policy implications

    OpenAIRE

    R Banai

    1993-01-01

    In this paper an argument is developed in support of the relevance of social theory for the region. Characterized by bridging across conceptual and methodological divides, by the increasing prominence of the role of space, context, and human agency, social theory exhibits an affinity with the regional development theory of the Regional Planning Association of America (RPAA) in the 1920s. This paper provides a brief account of the RPAA's approach to regional synthesis. The author alms to build...

  5. Field Test of Boiler Primary Loop Temperature Controller

    Energy Technology Data Exchange (ETDEWEB)

    Glanville, P.; Rowley, P.; Schroeder, D.; Brand, L.

    2014-09-01

    Beyond these initial system efficiency upgrades are an emerging class of Advanced Load Monitoring (ALM) aftermarket controllers that dynamically respond to the boiler load, with claims of 10% to 30% of fuel savings over a heating season. For hydronic boilers specifically, these devices perform load monitoring, with continuous measurement of supply and in some cases return water temperatures. Energy savings from these ALM controllers are derived from dynamic management of the boiler differential, where a microprocessor with memory of past boiler cycles prevents the boiler from firing for a period of time, to limit cycling losses and inefficient operation during perceived low load conditions. These differ from OTR controllers, which vary boiler setpoint temperatures with ambient conditions while maintaining a fixed differential. PARR installed and monitored the performance of one type of ALM controller, the M2G from Greffen Systems, at multifamily sites in the city of Chicago and its suburb Cary, IL, both with existing OTR control. Results show that energy savings depend on the degree to which boilers are over-sized for their load, represented by cycling rates. Also savings vary over the heating season with cycling rates, with greater savings observed in shoulder months. Over the monitoring period, over-sized boilers at one site showed reductions in cycling and energy consumption in line with prior laboratory studies, while less over-sized boilers at another site showed muted savings.

  6. The muscle CT of thigh in chronic Werdnig-Hoffmann disease

    International Nuclear Information System (INIS)

    Horikawa, Hirosei; Konagaya, Masaaki; Takayanagi, Tetsuya; Otsuji, Hideaki

    1986-01-01

    In this paper, the muscle CT of thigh in chronic Werdnig-Hoffmann disease (chronic WH) was evaluated. The subjects were five cases of chronic WH (3 males and 2 females, ages ranging from 6 to 22 years) and four control males. All cases showed symmetrical muscular weakness. The proximal muscle were more affected than the distal in the upper limbs. But the muscle strength of hip adduction was relatively spared as compared with other strength of lower limbs. The CT scan was carried out at the upper quarter level between lesser trochanter and medial condyle of the femur. The muscle CT of cases aged 6 and 7 years showed the severely decreased cross-sectional area of muscle without significant decrease in density. The atrophic muscles were surrounded by a large amount of low density area. The hamstring muscles and the adductor muscles, especially adductor longus muscle (ALM), were less affected than the quadriceps femoris muscles. Spotty and moth-eaten low density areas were observed dominantly in the severely affected muscles. In the advanced cases, only ALM could be identified on the CT image. The other muscles were unable to be identified because of severe atrophy with extremely low density. These CT findings suggest the process of muscular wastings of chronic WH as follows; at first muscle fibers are atrophied due to denervation and sooner or later replaced with fat tissue. Moreover, the preservation of ALM suggests that loss of anterior horn cells does not always go on homogeneously. (author)

  7. Utility of Clinical Parameters and Multiparametric MRI as Predictive Factors for Differentiating Uterine Sarcoma From Atypical Leiomyoma.

    Science.gov (United States)

    Bi, Qiu; Xiao, Zhibo; Lv, Fajin; Liu, Yao; Zou, Chunxia; Shen, Yiqing

    2018-02-05

    The objective of this study was to find clinical parameters and qualitative and quantitative magnetic resonance imaging (MRI) features for differentiating uterine sarcoma from atypical leiomyoma (ALM) preoperatively and to calculate predictive values for uterine sarcoma. Data from 60 patients with uterine sarcoma and 88 patients with ALM confirmed by surgery and pathology were collected. Clinical parameters, qualitative MRI features, diffusion-weighted imaging with apparent diffusion coefficient values, and quantitative parameters of dynamic contrast-enhanced MRI of these two tumor types were compared. Predictive values for uterine sarcoma were calculated using multivariable logistic regression. Patient clinical manifestations, tumor locations, margins, T2-weighted imaging signals, mean apparent diffusion coefficient values, minimum apparent diffusion coefficient values, and time-signal intensity curves of solid tumor components were obvious significant parameters for distinguishing between uterine sarcoma and ALM (all P Abnormal vaginal bleeding, tumors located mainly in the uterine cavity, ill-defined tumor margins, and mean apparent diffusion coefficient values of uterine sarcoma. When the overall scores of these four predictors were greater than or equal to 7 points, the sensitivity, the specificity, the accuracy, and the positive and negative predictive values were 88.9%, 99.9%, 95.7%, 97.0%, and 95.1%, respectively. The use of clinical parameters and multiparametric MRI as predictive factors was beneficial for diagnosing uterine sarcoma preoperatively. These findings could be helpful for guiding treatment decisions. Copyright © 2018 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  8. Survey of Leafhopper Species in Almond Orchards Infected with Almond Witches'-Broom Phytoplasma in Lebanon

    Science.gov (United States)

    Hammad, Efat Abou-Fakhr; El-Mohtar, Choaa; Abou-Jawdah, Yusuf

    2011-01-01

    Leafhoppers (Hemiptera: Auchenorrhyncha: Cicadellidae) account for more than 80% of all “Auchenorrhynchous” vectors that transmit phytoplasmas. The leafhopper populations in two almond witches'-broom phytoplasma (AlmWB) infected sites: Tanboureet (south of Lebanon) and Bourj El Yahoudieh (north of Lebanon) were surveyed using yellow sticky traps. The survey revealed that the most abundant species was Asymmetrasca decedens, which represented 82.4% of all the leafhoppers sampled. Potential phytoplasma vectors in members of the subfamilies Aphrodinae, Deltocephalinae, and Megophthalminae were present in very low numbers including: Aphrodes makarovi, Cicadulina bipunctella, Euscelidius mundus, Fieberiella macchiae, Allygus theryi, Circulifer haematoceps, Neoaliturus transversalis, and Megophthalmus scabripennis. Allygus theryi (Horváth) (Deltocephalinae) was reported for the first time in Lebanon. Nested PCR analysis and sequencing showed that Asymmetrasca decedens, Empoasca decipiens, Fieberiella macchiae, Euscelidius mundus, Thamnottetix seclusis, Balclutha sp., Lylatina inexpectata, Allygus sp., and Annoplotettix danutae were nine potential carriers of AlmWB phytoplasma. Although the detection of phytoplasmas in an insect does not prove a definite vector relationship, the technique is useful in narrowing the search for potential vectors. The importance of this information for management of AlmWB is discussed. PMID:21864154

  9. Simulating wind and marine hydrokinetic turbines with actuator lines in RANS and LES

    Science.gov (United States)

    Bachant, Peter; Wosnik, Martin

    2015-11-01

    As wind and marine hydrokinetic (MHK) turbine designs mature, focus is shifting towards improving turbine array layouts for maximizing overall power output, i.e., minimizing wake interference for axial-flow or horizontal-axis turbines, or taking advantage of constructive wake interaction for cross-flow or vertical-axis turbines. Towards this goal, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. The ALM predicts turbine loading with the blade element method combined with sub-models for dynamic stall and flow curvature. The open-source software is written as an extension library for the OpenFOAM CFD package, which allows the ALM body force to be applied to their standard RANS and LES solvers. Turbine forcing is also applied to volume of fluid (VOF) models, e.g., for predicting free surface effects on submerged MHK devices. An additional sub-model is considered for injecting turbulence model scalar quantities based on actuator line element loading. Results are presented for the simulation of performance and wake dynamics of axial- and cross-flow turbines and compared with moderate Reynolds number experiments and body-fitted mesh, blade-resolving CFD. Work supported by NSF-CBET grant 1150797.

  10. An Efficient Augmented Lagrangian Method for Statistical X-Ray CT Image Reconstruction.

    Science.gov (United States)

    Li, Jiaojiao; Niu, Shanzhou; Huang, Jing; Bian, Zhaoying; Feng, Qianjin; Yu, Gaohang; Liang, Zhengrong; Chen, Wufan; Ma, Jianhua

    2015-01-01

    Statistical iterative reconstruction (SIR) for X-ray computed tomography (CT) under the penalized weighted least-squares criteria can yield significant gains over conventional analytical reconstruction from the noisy measurement. However, due to the nonlinear expression of the objective function, most exiting algorithms related to the SIR unavoidably suffer from heavy computation load and slow convergence rate, especially when an edge-preserving or sparsity-based penalty or regularization is incorporated. In this work, to address abovementioned issues of the general algorithms related to the SIR, we propose an adaptive nonmonotone alternating direction algorithm in the framework of augmented Lagrangian multiplier method, which is termed as "ALM-ANAD". The algorithm effectively combines an alternating direction technique with an adaptive nonmonotone line search to minimize the augmented Lagrangian function at each iteration. To evaluate the present ALM-ANAD algorithm, both qualitative and quantitative studies were conducted by using digital and physical phantoms. Experimental results show that the present ALM-ANAD algorithm can achieve noticeable gains over the classical nonlinear conjugate gradient algorithm and state-of-the-art split Bregman algorithm in terms of noise reduction, contrast-to-noise ratio, convergence rate, and universal quality index metrics.

  11. Endocrine determinants of incident sarcopenia in middle-aged and elderly European men

    Science.gov (United States)

    Gielen, Evelien; O'Neill, Terence W; Pye, Stephen R; Adams, Judith E; Wu, Frederick C; Laurent, Michaël R; Claessens, Frank; Ward, Kate A; Boonen, Steven; Bouillon, Roger; Vanderschueren, Dirk; Verschueren, Sabine

    2015-01-01

    Background In men, the long-term consequences of low serum levels of sex steroids, vitamin D metabolites, and insulin-like growth factor 1 (IGF-1) on the evolution of muscle mass, muscle strength, or physical performance are unclear. Moreover, there are no data about the relationship between these hormones and incident sarcopenia defined as low muscle mass and function. The aim of this study was to determine whether the baseline levels of sex hormones, vitamin D metabolites, and IGF-1 predict changes in muscle mass, muscle strength, physical performance, and incident sarcopenia. Methods In 518 men aged 40–79 years, recruited for participation in the European Male Ageing Study, total, free, and bioavailable testosterone (T), oestradiol (E), sex hormone-binding globulin, IGF-1, 25-hydroxyvitamin D (25OHD), 1,25-dihydroxyvitamin D (1,25(OH)2D), and parathyroid hormone were assessed at baseline. Appendicular lean mass (aLM), gait speed, and grip strength were measured at baseline and after a mean follow-up of 4.3 years. Sarcopenia was defined by the definition of Baumgartner (relative aLM ≤7.26 kg/m2), the International Working Group on Sarcopenia (IWGS), and the European Working Group on Sarcopenia in Older People (EWGSOP). Results aLM significantly decreased from age 50 years, while gait speed and grip strength significantly decreased from age 70 years. The incidence of sarcopenia by the definitions of Baumgartner, IWGS, and EWGSOP was 8.1%, 3.0%, and 1.6%, respectively. After adjustment for age, centre, body mass index, smoking, and number of comorbidities at baseline, baseline levels of T and vitamin D metabolites were not associated with change in aLM, gait speed, and/or grip strength, while a high baseline level of total E2 was associated with a greater decrease in aLM. In men aged ≥70 years, low IGF-1 was associated with a greater decrease in gait speed. Baseline endocrine variables were not independently associated with an increased risk of incident

  12. Trans-Amazonian U-Th-Pb monazite ages and P-T-d exhumation paths of garnet-bearing leucogranite and migmatitic country rock of the southeastern Tandilia belt, Rio de la Plata craton in Argentina

    Science.gov (United States)

    Martínez, Juan Cruz; Massonne, Hans-Joachim; Frisicale, María Cristina; Dristas, Jorge A.

    2017-03-01

    A garnet-bearing leucogranite and two country rocks from the Transamazonian Tandilia belt of the Rio de la Plata craton were studied in detail. The leucogranite contains garnet with homogeneous composition of pyr6(gros + andr)2spes5alm87. In a garnet-biotite migmatite, the core and rim compositions of garnet are pyr1.7(gros + andr)5spes5.6alm87.7 and pyr1.2(gros + andr)5.5spes6.7alm86.6, respectively. These compositions in a sillimanite-garnet-muscovite migmatite are pyr4(gros + andr)2.7spes2.7alm90.6 and pyr2.7(gros + andr)4spes3.2alm90.1, respectively. We used this information to decipher the P-T evolution of the rocks applying P-T and T-H2O pseudosections with the PERPLE_X computer software package taking into consideration deformational microstructures. The leucogranite records an isothermal decompression from 5.3 to 3.8 kbar at 665 °C. The garnet-biotite migmatite was exhumed from 5.5 kbar at 630 °C to 4.3 kbar at 615 °C and the sillimanite-garnet-muscovite migmatite from supersolidus conditions of 670 °C and 3.6 kbar to 625 °C at 2.4 kbar. Late andalusite formed in this rock. Seventy four analyses of 28 monazite grains of the country rocks yielded three groups of U-Th-Pb ages which were related to a collisional event (I: ca. 2.13-2.14 Ga.), a postcollisional thermal overprint (II: ca. 2.01 Ga) and slow cooling of the orogen (III: 1.80-1.90 Ga). Inherited ages of 2.28 and 2.25 Ga could refer to an early accretionary stage of the orogen. An age of 2.41 Ga indicates the presence of recycled Siderian continental crust. Synkinematic crystallization of melts and the subsolidus development of an S2-foliation, demonstrated by deformational microstructures, occurred during the exhumation of the studied area from depths of 18 km to 8 km in the time interval 2.01-1.90 Ga.

  13. Program Evaluation - Automotive Lightweighting Materials Program Research and Development Projects Assessment of Benefits - Case Studies No. 2

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.

    2003-01-23

    This report is the second of a series of studies to evaluate research and development (R&D) projects funded by the Automotive Lightweighting Materials (ALM) Program of the Office of Advanced Automotive Technologies (OAAT) of the U.S. Department of Energy (DOE). The objectives of the program evaluation are to assess short-run outputs and long-run outcomes that may be attributable to the ALM R&D projects. The ALM program focuses on the development and validation of advanced technologies that significantly reduce automotive vehicle body and chassis weight without compromising other attributes such as safety, performance, recyclability, and cost. Funded projects range from fundamental materials science research to applied research in production environments. Collaborators on these projects include national laboratories, universities, and private sector firms, such as leading automobile manufacturers and their suppliers. Three ALM R&D projects were chosen for this evaluation: Design and Product Optimization for Cast Light Metals, Durability of Lightweight Composite Structures, and Rapid Tooling for Functional Prototyping of Metal Mold Processes. These projects were chosen because they have already been completed. The first project resulted in development of a comprehensive cast light metal property database, an automotive application design guide, computerized predictive models, process monitoring sensors, and quality assurance methods. The second project, the durability of lightweight composite structures, produced durability-based design criteria documents, predictive models for creep deformation, and minimum test requirements and suggested test methods for establishing durability properties and characteristics of random glass-fiber composites for automotive structural composites. The durability project supported Focal Project II, a validation activity that demonstrates ALM program goals and reduces the lead time for bringing new technology into the marketplace. Focal

  14. Do the eclogites of the Variscan Malpica-Tuy shear zone in NW Spain point to continental subduction?

    Science.gov (United States)

    Li, Botao; Massonne, Hans-Joachim

    2014-05-01

    High-pressure (HP: P > 10 kbar) rocks such as eclogite typically occur in suture zones of collided continental plates in Phanerozoic times. In case of an extended area at the surface of a denuded orogen with HP and even ultrahigh pressure (UHP) metamorphic rocks, they are often interpreted as the result of continental subduction. We have tested this idea for the HP-UHP area of the Malpica-Tuy zone of the Variscan orogen, which was formed by the collision of Gondwana and Laurussia. For the test, we have initially studied an eclogite and its surrounding gneiss of this zone in detail. The eclogite contains the assemblage garnet, omphacite, amphibole, rutile, ilmenite, clinozoisite/epidote, quartz, and phengite with Si-contents as high as 3.45 per formula unit (pfu) in inner portions and 3.27-3.35 pfu in rims. Garnet exhibits chemical zonation with Gro25Alm55Pyr15Spe5, Gro29Alm57Pyr13Spe1, and Gro23Alm56Pyr20Spe1 as inner core, mantle, and outermost rim compositions, respectively. The gneiss is a former medium-grained granite now composed of quartz, plagioclase, K-feldspar, biotite, phengite, garnet, clinozoisite/epidote, titanite, apatite and ilmenite. Phengite shows Si contents between 3.40 (core) and 3.00 (rim) pfu. Garnet is chemically zoned with Gro69.6Alm27Pyr0.4Spe3, Gro65.5Alm32.5Pyr0.5Spe1.5, Gro65.7Alm31.7Pyr0.6Spe2, and Gro56.6Alm41.6Pyr1.2Spe0.6 as core, mantle, rim and outermost rim compositions, respectively. P-T pseudosections were calculated with the PERPLEX computer program in the system Na2O-K2O-CaO-FeO-O2-MnO-MgO-Al2O3-SiO2-TiO2-H2O for the bulk-rock compositions of the studied eclogite and gneiss. These pseudosections were contoured by isopleths of various parameters such as molar fractions of garnet components. Based on this contouring a P-T path was derived that starts at HP conditions for both lithologies. Garnet began to form at 22 kbar and 565°C in the eclogite. Subsequently, the temperatures increased to 585°C and the pressure decreased to

  15. Comparison of left and right ventricular volume measurement using the Simpson's method and the area length method

    International Nuclear Information System (INIS)

    Hergan, Klaus; Schuster, Antonius; Fruehwald, Julia; Mair, Michael; Burger, Ralph; Toepker, Michael

    2008-01-01

    Purpose: To compare ventricular volume measurement using a volumetric approach in the three standard cardiac planes and ventricular volume estimation by a geometrical model, the Area-Length method (ALM). Materials and methods: Fifty-six healthy volunteers were examined (27 males, 29 females) on a 1.5 T MR-unit with ECG-triggered steady state free precision (SSFP) Cine-MR sequences and parallel image acquisition. Multiple slices in standardized planes including the short-axis view (sa), 4-chamber view (4ch), left and right 2-chamber views (2ch) were used to cover the whole heart. End-systolic and end-diastolic ventricular volumes (EDV, ESV), stroke volume (SV), and ejection fraction (EF) were calculated with Simpson's rule in all planes and with ALM in the 2ch and 4ch planes. Global function parameters measured in the sa plane were compared with those obtained in the other imaging planes. Results: A very good correlation is observed when comparing functional parameters calculated with Simpson's rule in all imaging planes: for instance, the mean EDV/ESV of the left and right ventricle of the female population group measured in sa, 4ch, and 2ch: left ventricle EDV/ESV 114.3/44.4, 120.9/46.5, and 117.7/45.3 ml; right ventricle EDV/ESV 106.6/46.0, 101.2/41.1, and 103.5/43.0 ml. Functional parameters of the left ventricle calculated with ALM in 2ch and 4ch correlate to parameters obtained in sa with Simpson's rule in the range of 5-10%: for instance, the EDV/ESV of the left ventricle of the male population group measured in the sa, 4ch, and 2ch: 160.3/63.5, 163.1/59.0, and 167.0/65.7 ml. Functional parameters of the right ventricle measured with ALM in 4ch are 40-50% lower and calculated in 2ch almost double as high as compared with the parameters obtained in sa with Simpson's rule: for instance, male right ventricular EDV/ESV measured in sa, 4ch, and 2ch: 153.4/68.1, 97.5/34.5, and 280.2/123.2 ml. The EF correlates for all imaging planes measured with the Simpson's rule

  16. Bacmeta: simulator for genomic evolution in bacterial metapopulations.

    Science.gov (United States)

    Sipola, Aleksi; Marttinen, Pekka; Corander, Jukka

    2018-02-20

    The advent of genomic data from densely sampled bacterial populations has created a need for flexible simulators by which models and hypotheses can be efficiently investigated in the light of empirical observations. Bacmeta provides fast stochastic simulation of neutral evolution within a large collection of interconnected bacterial populations with completely adjustable connectivity network. Stochastic events of mutations, recombinations, insertions/deletions, migrations and microepidemics can be simulated in discrete non-overlapping generations with a Wright-Fisher model that operates on explicit sequence data of any desired genome length. Each model component, including locus, bacterial strain, population, and ultimately the whole metapopulation, is efficiently simulated using C ++ objects, and detailed metadata from each level can be acquired. The software can be executed in a cluster environment using simple textual input files, enabling, e.g., large-scale simulations and likelihood-free inference. Bacmeta is implemented with C ++ for Linux, Mac and Windows. It is available at https://bitbucket.org/aleksisipola/bacmeta under the BSD 3-clause license. aleksi.sipola@helsinki.fi, jukka.corander@medisin.uio.no. Supplementary data are available at Bioinformatics online.

  17. The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass

    Directory of Open Access Journals (Sweden)

    Roma Krzymińska-Siemaszko

    2015-08-01

    Full Text Available The aim of the study was to assess the effect of a polyunsaturated omega-3 fatty acids (PUFA supplementation on the parameters of body composition, muscle strength and physical performance in elderly people with decreased muscle mass (DMM. Fifty three elderly people with an ALM index (the ratio of appendicular lean mass to squared height either below (−2SD: low muscle mass-LMM or between (−1SD and −2SD: the risk of LMM-rLMM the ALM index for the young Polish reference population were randomly assigned to PUFA-treated groups (LMM-PUFA, rLMM-PUFA or control groups (LMM-control, rLMM-control. PUFA-treated groups received capsules containing 1.3 g of PUFA and 10 mg of vitamin E, while the control groups received 11 mg of vitamin E daily for 12 weeks. Body composition (BIA analysis, muscle strength (hand grip measured with dynamometer and physical performance (Timed Up and Go test-TUG were assessed before and after supplementation. No statistically significant differences were observed either in muscle mass or in the hand grip and TUG in any group. The post-pre difference (mean ± SD in ALM index was as follows (kg/m2: LMM-PUFA: 0.00 ± 0.30, rLMM-PUFA: 0.00 ± 0.22, LMM-control: 0.03 ± 0.36, rLMM-control: –0.03 ± 0.20. In our study, a 12 week supplementation of PUFA did not affect the evaluated parameters in elderly individuals with DMM.

  18. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people.

    Science.gov (United States)

    Tieland, M; Brouwer-Brolsma, E M; Nienaber-Rousseau, C; van Loon, L J C; De Groot, L C P G M

    2013-10-01

    Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the association between vitamin D intake and serum 25(OH)D status with muscle mass, strength and physical performance in a pre-frail and frail elderly population. This cross-sectional study included 127 pre-frail and frail elderly people in The Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X-ray absorptiometry), leg strength (one repetition maximum), handgrip strength and physical performance (short physical performance battery) were measured, and blood samples were collected for the assessment of serum 25(OH)D status (liquid chromatography-tandem mass spectrometry). In addition, habitual dietary intake (3-day food records) and physical activity data (accelerometers) were collected. In total, 53% of the participants had a serum 25(OH)D level below 50  nmol/l. After adjustment for confounding factors, 25(OH)D status was associated with ALM (β=0.012, P=0.05) and with physical performance (β=0.020, PVitamin D intake was associated with physical performance (β=0.18, P0.05). In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance. In addition, vitamin D intake tended to be associated with impaired physical performance. Our findings highlight the need for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance in pre-frail and frail elderly people.

  19. Invited Review Article: Advanced light microscopy for biological space research

    Science.gov (United States)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; van Loon, Jack J. W. A.; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  20. Invited Review Article: Advanced light microscopy for biological space research

    International Nuclear Information System (INIS)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; Loon, Jack J. W. A. van; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-01-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy

  1. Large Eddy Simulation of Vertical Axis Wind Turbine Wakes

    Directory of Open Access Journals (Sweden)

    Sina Shamsoddin

    2014-02-01

    Full Text Available In this study, large eddy simulation (LES is combined with a turbine model to investigate the wake behind a vertical-axis wind turbine (VAWT in a three-dimensional turbulent flow. Two methods are used to model the subgrid-scale (SGS stresses: (a the Smagorinsky model; and (b the modulated gradient model. To parameterize the effects of the VAWT on the flow, two VAWT models are developed: (a the actuator swept-surface model (ASSM, in which the time-averaged turbine-induced forces are distributed on a surface swept by the turbine blades, i.e., the actuator swept surface; and (b the actuator line model (ALM, in which the instantaneous blade forces are only spatially distributed on lines representing the blades, i.e., the actuator lines. This is the first time that LES has been applied and validated for the simulation of VAWT wakes by using either the ASSM or the ALM techniques. In both models, blade-element theory is used to calculate the lift and drag forces on the blades. The results are compared with flow measurements in the wake of a model straight-bladed VAWT, carried out in the Institute de Méchanique et Statistique de la Turbulence (IMST water channel. Different combinations of SGS models with VAWT models are studied, and a fairly good overall agreement between simulation results and measurement data is observed. In general, the ALM is found to better capture the unsteady-periodic nature of the wake and shows a better agreement with the experimental data compared with the ASSM. The modulated gradient model is also found to be a more reliable SGS stress modeling technique, compared with the Smagorinsky model, and it yields reasonable predictions of the mean flow and turbulence characteristics of a VAWT wake using its theoretically-determined model coefficient.

  2. Invited Review Article: Advanced light microscopy for biological space research

    Energy Technology Data Exchange (ETDEWEB)

    De Vos, Winnok H., E-mail: winnok.devos@uantwerpen.be [Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp (Belgium); Cell Systems and Imaging Research Group, Department of Molecular Biotechnology, Ghent University, Ghent (Belgium); Beghuin, Didier [Lambda-X, Nivelles (Belgium); Schwarz, Christian J. [European Space Agency (ESA), ESTEC, TEC-MMG, Noordwijk (Netherlands); Jones, David B. [Institute for Experimental Orthopaedics and Biomechanics, Philipps University, Marburg (Germany); Loon, Jack J. W. A. van [Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center and Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, Amsterdam (Netherlands); Bereiter-Hahn, Juergen; Stelzer, Ernst H. K. [Physical Biology, BMLS (FB15, IZN), Goethe University, Frankfurt am Main (Germany)

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  3. A mechanistic diagnosis of the simulation of soil CO2 efflux of the ACME Land Model

    Science.gov (United States)

    Liang, J.; Ricciuto, D. M.; Wang, G.; Gu, L.; Hanson, P. J.; Mayes, M. A.

    2017-12-01

    Accurate simulation of the CO2 efflux from soils (i.e., soil respiration) to the atmosphere is critical to project global biogeochemical cycles and the magnitude of climate change in Earth system models (ESMs). Currently, the simulated soil respiration by ESMs still have a large uncertainty. In this study, a mechanistic diagnosis of soil respiration in the Accelerated Climate Model for Energy (ACME) Land Model (ALM) was conducted using long-term observations at the Missouri Ozark AmeriFlux (MOFLUX) forest site in the central U.S. The results showed that the ALM default run significantly underestimated annual soil respiration and gross primary production (GPP), while incorrectly estimating soil water potential. Improved simulations of soil water potential with site-specific data significantly improved the modeled annual soil respiration, primarily because annual GPP was simultaneously improved. Therefore, accurate simulations of soil water potential must be carefully calibrated in ESMs. Despite improved annual soil respiration, the ALM continued to underestimate soil respiration during peak growing seasons, and to overestimate soil respiration during non-peak growing seasons. Simulations involving increased GPP during peak growing seasons increased soil respiration, while neither improved plant phenology nor increased temperature sensitivity affected the simulation of soil respiration during non-peak growing seasons. One potential reason for the overestimation of the soil respiration during non-peak growing seasons may be that the current model structure is substrate-limited, while microbial dormancy under stress may cause the system to become decomposer-limited. Further studies with more microbial data are required to provide adequate representation of soil respiration and to understand the underlying reasons for inaccurate model simulations.

  4. Antigenic profile of heat-killed versus thimerosal-treated Leishmania major using sodium dodecyl sulfate-polyacrylamide gel electrophoresis

    Directory of Open Access Journals (Sweden)

    Reza Arjmand

    2015-01-01

    Full Text Available Background: Leishmania is a parasitic protozoan of trypanosomatidae family which causes a wide spectrum of diseases ranging from self-healing cutaneous lesions to deadly visceral forms. In endemic areas, field trials of different preparations of Leishmania total antigen were tested as leishmaniasis vaccine. Two preparations of killed Leishmania major were produced In Iran, which were heat-killed vaccine called autoclaved L. major (ALM and thimerosal-treated freeze-thawed vaccine called killed L. major (KLM. In this study, the protein content of both ALM and KLM were compared with that of freshly harvested intact L. major promastigotes using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE. Materials and Methods: L. major (MRHO/IR/75/ER from pre-infected Balb/c mice was isolated with modified Novy-MacNeal-Nicolle (NNN medium and then subcultured in liquid RPMI 1640 medium supplemented with fetal calf serum (FCS 20% for mass production. Two preparations of KLM and ALM were produced by Razi Vaccine and Serum Research Institute, Iran, under WHO/TDR supervision. Electrophoresis was performed by SDS-PAGE method and the gel was stained by Coomassie brilliant blue dye. The resultant unit bands were compared using standard molecular proteins. Results: Electrophoresis of the two preparations produced many bands from 10 kDa to 100 kDa. KLM bands were much like those of freshly harvested intact L. major. Conclusion: It is concluded that although there are similar bands in the three forms of Leishmania antigens, there are some variations which might be considered for identification and purification of protective immunogens in a total crude antigen, and detection of their stability is essential for the production and marketing of a putative vaccine.

  5. Introduction of active learning method in learning physiology by MBBS students.

    Science.gov (United States)

    Gilkar, Suhail Ahmad; Lone, Shabiruddin; Lone, Riyaz Ahmad

    2016-01-01

    Active learning has received considerable attention over the past several years, often presented or perceived as a radical change from traditional instruction methods. Current research on learning indicates that using a variety of teaching strategies in the classroom increases student participation and learning. To introduce active learning methodology, i.e., "jigsaw technique" in undergraduate medical education and assess the student and faculty response to it. This study was carried out in the Department of Physiology in a Medical College of North India. A topic was chosen and taught using one of the active learning methods (ALMs), i.e., jigsaw technique. An instrument (questionnaire) was developed in English through an extensive review of literature and was properly validated. The students were asked to give their response on a five-point Likert scale. The feedback was kept anonymous. Faculty also provided their feedback in a separately provided feedback proforma. The data were collected, compiled, and analyzed. Of 150 students of MBBS-first year batch 2014, 142 participated in this study along with 14 faculty members of the Physiology Department. The majority of the students (>90%) did welcome the introduction of ALM and strongly recommended the use of such methods in teaching many more topics in future. 100% faculty members were of the opinion that many more topics shall be taken up using ALMs. This study establishes the fact that both the medical students and faculty want a change from the traditional way of passive, teacher-centric learning, to the more active teaching-learning techniques.

  6. Assessment of Algal Farm Designs Using a Dynamic Modular Approach

    Energy Technology Data Exchange (ETDEWEB)

    Abodeely, Jared [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Coleman, Andre M. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Hydrology Technical Group; Stevens, Daniel M. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Ray, Allison E. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Cafferty, Kara G. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology; Newby, Deborah T. [Idaho National Laboratory (INL), Idaho Falls, ID (United States). Biofuels and Renewable Energy Technology

    2014-07-01

    The notion of renewable energy provides an important mechanism for diversifying an energy portfolio, which ultimately would have numerous benefits including increased energy resilience, reduction of foreign energy supplies, reduced GHG emissions, development of a green energy sector that contributes to economic growth, and providing a sustainable energy supply. The conversion of autotrophic algae to liquid transportation fuels is the basis of several decades of research to competitively bring energy-scale production into reality; however, many challenges still remain for making algal biofuels economically viable. Addressing current challenges associated with algal production systems, in part, requires the ability to assess spatial and temporal variability, rapidly evaluate alternative algal production system designs, and perform large-scale assessments considering multiple scenarios for thousands of potential sites. We introduce the Algae Logistics Model (ALM) which helps to address these challenges. The flexible nature of the ALM architecture allows the model to: 1) interface with external biomass production and resource assessment models, as well as other relevant datasets including those with spatiotemporal granularity; 2) interchange design processes to enable operational and economic assessments of multiple design configurations, including the integration of current and new innovative technologies; and 3) conduct trade-off analysis to help understand the site-specific techno-economic trade-offs and inform technology decisions. This study uses the ALM to investigate a baseline open-pond production system determined by model harmonization efforts conducted by the U.S. Department of Energy. Six sites in the U.S. southern-tier were sub-selected and assessed using daily site-specific algae biomass productivity data to determine the economic viability of large-scale open-pond systems. Results show that costs can vary significantly depending on location and biomass

  7. Mechanisms of Protection from Interest Rate Risk with Reference to the Life Insurance Market in Montenegro

    Directory of Open Access Journals (Sweden)

    Burić Milijana Novović

    2018-01-01

    Full Text Available Insurance companies are facing major challenges that point to the need for control process and risk management. Risk management in insurance has a direct impact on solvency, economic security, and overall financial stability of insurance companies. It is very important for insurance companies to adequately calculate risks to which they are exposed. Asset liability management (ALM, as an integrated approach to financial management, requires simultaneous decision-making about categories and values of assets and liabilities in order to establish the optimum volume and the ratio of assets and liabilities, with the understanding of complexity of the financial market in which financial institutions operate. ALM focuses on a significant number of risks, whereby the emphasis in this paper will be on interest rate risk which indicates potential losses that may reflect in a lower interest margin, a lower value of assets or both, in terms of changes in interest rates. In the above context, the aim of this paper is to show how to protect from interest rate changes and how these changes influence the insurance market in Montenegro, both from the theoretical and the practical point of view. The authors consider this to be an interesting and very important topic, especially because the life insurance market in Montenegro is underdeveloped and subject to fluctuations. Also, taking into account the fact that Montenegro is a country that has been making serious efforts to join the EU, it is expected that insurance companies in Montenegro will strengthen their financial position in the market even using the ALM traditional techniques, which is shown in this paper.

  8. Health benefits of a reduction of PM10 and NO2 exposure after implementing a clean air plan in the Agglomeration Lausanne-Morges.

    Science.gov (United States)

    Castro, Alberto; Künzli, Nino; Götschi, Thomas

    2017-07-01

    Exposure to urban air pollution has been associated with adverse effects on cardio-vascular and respiratory health, both short and long term. Consequently, governments have applied policies to reduce air pollution. Quantitative health impact assessments of hypothetic changes in air pollution have been conducted at national and global level, but assessments of observed air pollution changes associated with specific clean air policies at a local or regional scale remain scarce. This study estimates health impacts attributable to a decrease in PM 10 and NO 2 exposure in the Agglomeration of Lausanne-Morges (ALM), Switzerland, between 2005 and 2015, corresponding to the implementation period of a supra-municipal plan of measures to reduce air pollution in different sectors such as transport, energy, and industry (called Plan OPair 05). The health impact assessment compares health effects attributed to air pollution exposure levels in 2015 (reference case) with those in 2005 (counterfactual scenario), using 2015 as baseline for all other input data. In the ALM, the modeled PM 10 exposure reduction of 3.3μg/m 3 from 2005 to 2015 prevents 26 premature deaths (equivalent to around 290 years of life lost), 215 hospitalization days due to cardio-vascular and respiratory diseases as well as approximately 47,000 restricted activity days annually. Monetized health impacts of the reduction of PM 10 exposure are valued at approximately CHF 36 million annually. Immaterial costs, mainly related to the economic valuation of years of life lost, dominate the monetized health impacts (90% of total value), while savings at the workplace (net loss in production and reoccupation costs) amount to about CHF 1.9 million, and savings in health care costs to about CHF 0.5 million. The assessment is sensitive to the value assigned to immaterial costs and to uncertainties in the relative risk estimates, whereas variations in the baseline year (i.e. using 2005 data instead of 2015 data) affect

  9. Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance

    Science.gov (United States)

    2015-11-01

    release in freely-moving rat. Location: Hall A-C Presentation time: Tuesday , Nov 15, 2011, 1:00 PM - 2:00 PM Authors: *J. VAZQUEZ, A. NGUYEN, T. KILDUFF...induces sleep in rats but does not impair spatial reference memory performance during wake Location: Hall A-C Presentation time: Tuesday , Nov 15, 2011, 2...of a platform in a spatial reference memory task ( Morris Water Maze). Next day, they were dosed with either ALM (100 mg/kg i.p.), ZOL (30 mg/kg i.p

  10. Sorter af afgræsningslucerne

    DEFF Research Database (Denmark)

    Søegaard, Karen

    2011-01-01

    – to nye sorter Verbena og Camboregio og en ældre sort Luzelle. Sorterne blev dyrket i renbestand og to forskellige blandinger med alm. rajgræs. Parcellerne blev afgræsset af kvier, med en forholdsvis hård afgræsning, i to forskellige slæt/afgræsnings systemer. Generelt klarede Verbena sig bedst og...... afgørende forskelle mellem denne ældre og de to nye sorter. Resultaterne for Luzelle lå generelt mellem Verbena og Camporegio....

  11. Os custos gerados pelo Sistema Tribut?rio Brasileiro e seus impactos no resultado econ?mico de um empreendimento de constru??o civil na cidade de Manaus.

    OpenAIRE

    Cavalcante Filho, Jos? Valdomiro Oliveira

    2009-01-01

    O Brasil possui uma das maiores cargas tribut?rias do mundo, correspondendo a cerca de 37% do Produto Interno Bruto, e um sistema tribut?rio bastante complexo, com mais de 80 tributos, 17 mil normas tribut?rias em vigor e um grande n?mero de obriga??es acess?rias. Verifica-se que o sistema tribut?rio gera um elevado custo para os contribuintes, que vai al?m do valor dos tributos, pois abrange ainda os custos de conformidade ? tributa??o, gerado pelas obriga??es acess?rias. Contudo, a C...

  12. Production of Polyhydroxyalkanoates from Sludge Palm Oil Using Pseudomonas putida S12.

    Science.gov (United States)

    Kang, Du-Kyeong; Lee, Cho-Ryong; Lee, Sun Hee; Bae, Jung-Hoon; Park, Young-Kwon; Rhee, Young Ha; Sung, Bong Hyun; Sohn, Jung-Hoon

    2017-05-28

    Polyhydroxyalkanoates (PHAs) are biodegradable plastics produced by bacteria, but their use in diverse applications is prohibited by high production costs. To reduce these costs, the conversion by Pseudomonas strains of P HAs from crude s ludge p alm oil ( SPO) a s an inexpensive renewable raw material was tested. Pseudomonas putida S12 was found to produce the highest yield (~41%) of elastomeric medium-chain-length (MCL)-PHAs from SPO. The MCL-PHA characteristics were analyzed by gas-chromatography/mass spectrometry, gel permeation chromatography, and differential scanning calorimetry. These findings may contribute to more widespread use of PHAs by reducing PHA production costs.

  13. Self-Tensioning Acoustical Horizontal Line Array (SPRAY) Data Analysis. Final Report of Bearing Stake Tests January thru March 1977, Volume IB. Detailed Description, Test Results

    Science.gov (United States)

    1979-01-01

    web " AL ***atfa IL X a 42 U 4j ft ut C IC a % % alms j we__w Z A CA 00- ’co 49 a. j -D Lbl ŘV (qw IA. .4L i ) ’IV Lhw . 94 U CD1 ca C. 1 1 .4 I~l...4C E: qw C Zw (1 - - 1U -7 -: - *t -r z~ -: do’.’.. ~ V.(O (11U * III ,~ * SS~ ŗ filU. * zu lc )0( Lid 014- CA__ G -4 0 I ~ IA L4,A t WIx W U V4 soft

  14. Processos lingu?sticos no cartaz de guerra: semi?tica e gram?tica do design visual

    OpenAIRE

    Fernandes, Jos? David Campos

    2009-01-01

    Imagens produzem e reproduzem rela??es sociais, comunicam fatos, divulgam eventos e interagem com seus leitores com uma for?a semelhante ? de um texto formado por palavras. Como g?nero eminentemente imag?tico, o cartaz, al?m de uma compreens?o, tamb?m requer em sua textura um processo de persuas?o, constru?do por um produtor para conquistar seu leitor. Nele, uma cadeia de elementos verbais e n?o-verbais dispostos na sua superf?cie de papel ? permeada por estrat?gias que, na mai...

  15. Investigación sobre la incidencia de las curvas de aprendizaje en los procesos productivos de las empresas del sector carrocero, cantón Ambato, provincia de Tungurahua.

    OpenAIRE

    Chango Galarza, Mariela Cristina; Zambrano Vallejo, María Isabel

    2014-01-01

    Este proyecto se realizó en la Provincia de Tungurahua cuyo tema consistió en la Investigación sobre la incidencia de las curvas de aprendizaje en los procesos productivos de las empresas del sector carrocero, tomando como objeto de estudio a las Carrocerías ALME, ubicada en la Ciudad de Ambato, la misma que se dedica a la fabricación de carrocerías para buses urbanos, provinciales e interprovinciales. El tema del proyecto está relacionado con la elaboración de Curvas de Aprendizaje para un d...

  16. SEDEKAH BUMI DUSUN CISAMPIH (Studi kasus di Dusun Cisampih Desa Kutabima Kecamatan Cimanggu-Cilacap-Jawa Tengah

    Directory of Open Access Journals (Sweden)

    zainal abidin

    2014-05-01

    Full Text Available Sedekah Bumi (earth’s alms is an ethnic ritual to show their high regard to the earth as a place to live in. People depend on earth as it is a place where they do farming, get drink and food, and do other activities. For this reason, they feel that there should be any ceremony that shows their gratitude to the earth. Besides that, sedekah bumi also reflects thankfulness for people’s walfare and fortune and it is also believed to bring abundant crops. In Islamic perspective, the ritual of Sedekah Bumi accords to some Islamic principles, however, some ideas are also contradicted.

  17. PERFORMANCE COMPARISON OF SCENARIO-GENERATION METHODS APPLIED TO A STOCHASTIC OPTIMIZATION ASSET-LIABILITY MANAGEMENT MODEL

    Directory of Open Access Journals (Sweden)

    Alan Delgado de Oliveira

    Full Text Available ABSTRACT In this paper, we provide an empirical discussion of the differences among some scenario tree-generation approaches for stochastic programming. We consider the classical Monte Carlo sampling and Moment matching methods. Moreover, we test the Resampled average approximation, which is an adaptation of Monte Carlo sampling and Monte Carlo with naive allocation strategy as the benchmark. We test the empirical effects of each approach on the stability of the problem objective function and initial portfolio allocation, using a multistage stochastic chance-constrained asset-liability management (ALM model as the application. The Moment matching and Resampled average approximation are more stable than the other two strategies.

  18. Relationship between the lability of sediment-bound Cd and its bioaccumulation in edible oyster

    Digital Repository Service at National Institute of Oceanography (India)

    Chakraborty, P.; Ramteke, D.; Chakraborty, S.; Chennuri, K.; Bardhan, P.

    unaffected by changes in Eh of the medium (Zia-ur-Rehman et al., 2015; Pascaud et al., 2015). Complexations of Cd with carbonate restrict mobility of Cd in carbonate-rich sediment and soil (Wu et al., 2015; Wang et al., 2015). Sekaly et al (1999) have... contribution number XXXX. References Almås, Å. R., McBride, M. B., & Singh, B. R. (2000). Solubility and lability of cadmium and zinc in two soils treated with organic matter. Soil Science, 165(3), 250-259. Broten, D. (1998). BC oysters face cadmium...

  19. Relationship between the lability of sediment-bound Cd and its bioaccumulation in edible oyster.

    Digital Repository Service at National Institute of Oceanography (India)

    Chakraborty, P.; Ramteke, D.; Chakraborty, S.; Chennuri, K.; Bardhan, P.

    unaffected by changes in Eh of the medium (Zia-ur-Rehman et al., 2015; Pascaud et al., 2015). Complexations of Cd with carbonate restrict mobility of Cd in carbonate-rich sediment and soil (Wu et al., 2015; Wang et al., 2015). Sekaly et al (1999) have... contribution number XXXX. References Almås, Å. R., McBride, M. B., & Singh, B. R. (2000). Solubility and lability of cadmium and zinc in two soils treated with organic matter. Soil Science, 165(3), 250-259. Broten, D. (1998). BC oysters face cadmium...

  20. Dicty_cDB: SSG766 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ( FJ151945 |pid:none) Ensatina eschscholtzii xanthoptica... 34 7.6 FJ151867_1( FJ151867 |pid:none) Ensatina eschscholtzii xanthoptica... 9.9 FJ151878_1( FJ151878 |pid:none) Ensatina eschscholtzii xanthoptica... 33 9.9 FJ151848_1( FJ151848 |pid:...none) Ensatina eschscholtzii xanthoptica... 33 9.9 FJ151923_1( FJ151923 |pid:none...) Ensatina eschscholtzii xanthoptica... 33 9.9 protein update 2009. 6.12 PSORT psg: 0.85 gvh: 0.37 alm: 0.33

  1. ?ndices f?sico-qu?micos e toxicol?gicos de frutos de c?bio (solanum sessiliflorum dunal) em diferentes est?dios de matura??o.

    OpenAIRE

    Andrade J?nior, Moacir Couto de

    2006-01-01

    O c?bio (Solanum sessiliflorum Dunal) ? um fruto com elevado potencial agroindustrial devido ? sua alta produtividade anual e caracter?sticas nutricionais (alto teor em fibras diet?ticas). Al?m disso, as fibras est?o contidas nos alimentos vegetais e t?m fun??es preventivas de doen?as cr?nico-degenerativas, a exemplo do diabetes mellitus e (ou) das dislipidemias, o que as situa na categoria de alimentos funcionais ou nutrac?uticos. N?o obstante, se, por um lado, algum conhecimento acerca do ...

  2. Dicty_cDB: VFA628 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 8 |pid:none) Methanobrevibacter smithii ATCC ... 42 0.017 CP001390_1265( CP001390 |pid:none) Geobacter sp. F...000678_1111( CP000678 |pid:none) Methanobrevibacter smithii ATCC... 36 0.91 (Q9Z3...otrophomonas maltophilia K27... 36 1.2 CP000678_996( CP000678 |pid:none) Methanobrevibacter smithii ATCC ......:none) Methanobrevibacter smithii ATCC ... 34 3.5 protein update 2009. 6.16 PSORT psg: 0.85 gvh: 0.47 alm: 0

  3. Comparison of four large-eddy simulation research codes and effects of model coefficient and inflow turbulence in actuator-line-based wind turbine modeling

    DEFF Research Database (Denmark)

    Martínez-Tossas, Luis A.; Churchfield, Matthew J.; Yilmaz, Ali Emre

    2018-01-01

    to match closely for all codes. The value of the Smagorinsky coefficient in the subgrid-scale turbulence model is shown to have a negligible effect on the time-averaged loads along the blades. Conversely, the breakdown location of the wake is strongly dependent on the Smagorinsky coefficient in uniform...... coefficient has a negligible effect on the wake profiles. It is concluded that for LES of wind turbines and wind farms using ALM, careful implementation and extensive cross-verification among codes can result in highly reproducible predictions. Moreover, the characteristics of the inflow turbulence appear...

  4. governan?a corporativa e desempenho financeiro no brasil, chile e m?xico

    OpenAIRE

    Pereira, Lucian Hendyo Max

    2014-01-01

    Um dos temas de atual discuss?o no campo de Finan?as, mas ainda em aberto a debates de cunho te?rico-emp?rico, ? o da Governan?a Corporativa. Algumas vezes relacionados a discuss?es sobre a relev?ncia das pr?ticas de Governan?a sobre o desempenho financeiro das empresas, em especial no contexto de pa?ses emergentes, trabalhos como os de Klapper e Love (2004), Braga-Alves e Morey (2012), Claessens e Fan (2002) e Claessens e Yutorglu (2013) buscaram, al?m da an?lise sobre o prisma de indicadore...

  5. Surface Effect Ship Structural Producibility. Part 3.

    Science.gov (United States)

    1980-05-14

    KSI FAILURE - ISo - .276 "A4p I ’ 1 7.". P’ALm ,. I.-u -1.-7 .4 1 "/,A 4s-77 I 3qQ# .’I FA iL & 0 I -a- Liii .L-,2 -22 𔄁, I jj ir.i F4I, i11 9 .4122 1...909603 POCI90’l 1L2 9 0, 1800770 1100916 12-9034 A2.Q0456 41005?, j290o.7* 41)9002 SO-0006? 27003 12700071 5000246 ar04132 81*00619 41.0911a 2#0O009O

  6. Use of butter and cheese in 10 European countries - A case of contrasting educational differences

    DEFF Research Database (Denmark)

    Prattala, R. S.; Groth, Margit Velsing; Oltersdorf, U. S.

    2003-01-01

    Background: This paper alms to analyse socioeconomic variation in the use of cheese and butter in Europe by reviewing existing dietary surveys. It explores whether socioeconomic differences in the intake of these foods follow a similar pattern in all countries. Methods: An overview of available s...... classes prefer modern foods,. lower classes traditional foods....... studies on socioeconomic differences in food habits in Europe over the period 1985-1997 was performed. Twenty studies from 10 countries included information on cheese and butter. A simple directional vote-counting method was used to register the association between educational level add consumption...

  7. Nordic food culture – A historical perspective

    OpenAIRE

    Amilien, Virginie

    2013-01-01

    Henry Notaker is a well- known Norwegian historian, specialist of books and articles about food, culture and history. He has got awards for journalism on food history, he was responsible for TV series about food and history in the 1990’s, and he is currently teaching in food history at the universities in Bergen and Agder and at Akershus University College (courses on food culture). Henry Notaker is a member of the editorial board of the scientific journal Food & History. He has published alm...

  8. New challenge: the development of social competition for peaceful coexistence

    Directory of Open Access Journals (Sweden)

    Rocío Ramírez Ibagon

    2005-02-01

    Full Text Available The present document describes the experiences obtained from the initiation of the Basic Development for Reconstruction of Social Abilities with Emphasis on Peaceful Co-Existence Programme. The programme includes young people who have enrolled in the National Reinsertion Programme to obtain their Secundary school Degree. It offers a profile of the population, a recount of the reasons why children and young people participate in armed conflict and also describes the reasons that influence their return. Finally, the paper makes mention of the alms and achievements of said experiences. 

  9. A rela??o entre os estilos de socializa??o materna e as concep??es de perd?o em adolescentes.

    OpenAIRE

    Santos, Lydia Maria Sena e

    2014-01-01

    O presente estudo buscou analisar a rela??o entre a percep??o dos adolescentes sobre os estilos de socializa??o materna e concep??es sobre perd?o. Os estilos de socializa??o parental s?o definidos como padr?es de atua??o caracter?sticos, que os pais utilizam em diversas situa??es do cotidiano. Esses padr?es caracterizam-se por um conjunto de t?cnicas e formas de atua??o dos pais, que abrangem desde atitudes de aceita??o at? atitudes de controle dos comportamentos indesejados, al?m da imposi??...

  10. FUNGSI SOSIAL BANK SYARIAH

    Directory of Open Access Journals (Sweden)

    Prehantoro

    2010-04-01

    Full Text Available Bank of Moslem law one of its target is profit oriented as financial institution intermediasi beside as institute of baitul maal. Bank of Moslem law can accept the fund coming from zakat , infak, alms, hibah, or other social fund which among other things come the ta’zir. Bank of Moslem law also channel it social fund coming from communal ownership of money to communal ownership organizer (nadzir as according to will ;desire of communal ownership giver (wakif. social Function execution have to pursuant to Statute of Management of Zakat and Statute of Wakaf.

  11. Amidas halogenadas: rea??es de acoplamento e investiga??o in silico da atividade antimicrobiana

    OpenAIRE

    Montes, Ricardo Carneiro

    2016-01-01

    O presente trabalho teve como finalidade preparar uma cole??o de benzilamidas para-halogenadas derivadas de ?cidos cin?micos e benzoicos estruturalmente relacionadas atrav?s de rea??es de acoplamento com 4-(cloro, fluro e bromo) benzilaminas, utilizando o benzotriazol-1-iloxi-tris-(dimetilamino)-fosf?nio (BOP) como agente de acoplamento. Al?m disso, foram preparados derivados ?teres e ?steres da amida do ?cido van?lico. Todos os compostos preparados foram submetidos a testes antimicrobianos p...

  12. The sixteenth-century altar painting of the Cattaran (Kotor fraternity of leather-makers

    Directory of Open Access Journals (Sweden)

    Živković Valentina

    2009-01-01

    Full Text Available The altar painting that the Cattaran Fraternity of Leather-makers commissioned from the Venetian painter Girolamo da Santa Croce in the first half of the sixteenth century contains the images of Sts Bartholomew, George and Antoninus. The presence of the first two saints is looked at from the perspective of a long-established religious tradition, while the reasons for depicting the archbishop Antoninus giving alms to the poor appear to reside in the then prevailing religious policy and the local social situation.

  13. Channeling and related crystal effects

    International Nuclear Information System (INIS)

    Uggerhoj, Erik

    1995-01-01

    Channeling, the interaction of particles with oriented crystals, has been applied in a wide variety of scientific and technological areas. A workshop at Aarhus, Denmark, this summer highlighted progress and future directions. Radiation emission has been explored and linked to coherent bremsstrahlung and other oriented crystal radiations. Dramatic effects have been found for ultra-relativistic electrons with Lorentz factors of 105 6. Single crystals are unique for investigations of quantum electrodynamics in strong external fields because probabilities for processes in axial/ planar fields are determined by the magnitude of these fields in the particle rest frame. Erik Uggerhoj of Aarhus reported on an extensive series of experiments concerning radiation emission, pair production, and shower formation carried out at CERN by the NA43 collaboration. As Vladimir Baier of Novosibirsk and Yuri Kononets of Kurchatov noted, theoretical treatment of these interconnected radiation distributions is challenging and much work needs to be done. In general, the agreement with the CERN experiments is good, but many areas like polarization phenomena and particle production need investigation. Prominent among high energy applications is extraction from accelerators. At the workshop, Alexei Asseev reported on beam extraction using a bent crystal at Serpukhov. Konrad Elsener and Jukka Klem reviewed recent CERN SPS studies driven by the possibility of using crystals for extraction of LHC beams. Thornton Murphy of Fermilab announced a step in that direction, with a demonstration this summer of extraction from the Tevatron at 900 GeV. Bent crystal channeling is also used for handling extracted high energy beams. Niels Doble presented a beautiful example of a beam for the CERN NA48 CP-violation experiment. Yuri Chesnokov reported that beams had been deflected through angles up to 150 milliradians at Serpukhov

  14. Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro

    Directory of Open Access Journals (Sweden)

    de Peppo GM

    2014-05-01

    Full Text Available Giuseppe Maria de Peppo,1–3 Hossein Agheli,2,3 Camilla Karlsson,2,3 Karin Ekström,2,3 Helena Brisby,3,4 Maria Lennerås,2,3 Stefan Gustafsson,3,5 Peter Sjövall,3,5,6 Anna Johansson,2,3 Eva Olsson,3,5 Jukka Lausmaa,3,6 Peter Thomsen,2,3 Sarunas Petronis3,6 1The New York Stem Cell Foundation Research Institute, New York, NY, USA; 2Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, 3BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, 4Department of Orthopaedics, Sahlgrenska Academy, University of Gothenburg, 5Applied Physics, Chalmers University of Technology, Göteborg, Sweden; 6Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, Borås, Sweden Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs. Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration. Keywords: colloidal lithography, nanotopography, human mesenchymal stem cells, cell proliferation, osteogenic

  15. Cutaneous Leiomyoma: Novel Histologic Findings for Classification and Diagnosis

    Directory of Open Access Journals (Sweden)

    Kambiz Kamyab Hesari

    2013-01-01

    Full Text Available Smooth muscle tumors rather benign or malignant can arise wherever the muscular tissue presents but cutaneous leiomyoma is one of the rare benign tumors of the which even the diagnostic criteria from the malignant type of the tumor is still in doubt. This study was aimed to compare the subtypes of cutaneous leiomyoma from different histologic aspects in order to find unique criteria for better classification and diagnosis. The six year data base of our center was reviewed and 25 patients with cutaneous leiomyoma were included in this study. Of 25 patients, 5 were female and 20 were male. 5 patients had angioleiomyoma (ALM and 20 had pilar leiomyoma (PLM. ALM had following characteristics: dilated vascular canals intermingled with compact smooth muscle bundles; well circumscribe counter and myxoid and hyaline changes through the tumor. In contrast, PLMs had following histologic features: poor defined outline, entrapped hair follicles and eccrine glands, acanthosis and elongated rete ridges with hyperpigmentation and smooth muscle bundles which are interdigitated with elongated rete ridges. Here we introduced some distinct histological features for each subtype of the cutaneous leiomyoma which can lead to create novel criteria for classification and diagnosis of the lesion.

  16. Wind farm fuzzy modelling for adequacy evaluation of power system

    Energy Technology Data Exchange (ETDEWEB)

    Moeini-Aghtaie, M.; Abbaspour, A.; Fotuhi-Firuzabad, M. [Sharif Univ. of Technology, Tehran (Iran, Islamic Republic of). Dept. of Electrical Engineering, Center of Excellence in Power System Management and Control

    2010-07-01

    This paper presented details of a fuzzy logic-based active learning method (ALM) designed to model variations in wind speed. A pattern-based approach was used to model system behaviour. The ALM was algorithmically modelled on the information-handling processes of the human brain. Wind data were gathered and projected on different data planes. The horizontal axis of each data plane was one of the inputs, while the vertical axis was the output. An ink drop spread (IDS) processing engine was used to look for behaviour curves on each data plane. A fuzzy interpolation method was used to derive a smooth curve among the data points. Sequential Monte Carlo simulations (MCS) were used to evaluate power systems based on hourly random simulations. After the hourly wind speed was generated, wind turbine generator outputs were calculated by considering the nonlinear relationship between the estimated wind speed and the wind turbine output. The developed algorithm was validated on a 6-bus reliability test system. Results of the study can be used by power system schedulers to develop power system reliability guidelines. 14 refs., 2 tabs., 11 figs.

  17. Study on Actuator Line Modeling of Two NREL 5-MW Wind Turbine Wakes

    Directory of Open Access Journals (Sweden)

    Ziying Yu

    2018-03-01

    Full Text Available The wind turbine wakes impact the efficiency and lifespan of the wind farm. Therefore, to improve the wind plant performance, research on wind plant control is essential. The actuator line model (ALM is proposed to simulate the wind turbine efficiently. This research investigates the National Renewable Energy Laboratory 5 Million Watts (NREL 5-MW wind turbine wakes with Open Field Operation and Manipulation (OpenFOAM using ALM. Firstly, a single NREL 5-MW turbine is simulated. The comparison of the power and thrust with Fatigue, Aerodynamics, Structures, and Turbulence (FAST shows a good agreement below the rated wind speed. The information relating to wind turbine wakes is given in detail. The top working status is proved at the wind speed of 8 m/s and the downstream distance of more than 5 rotor diameters (5D. Secondly, another case with two NREL 5-MW wind turbines aligned is also carried out, in which 7D is validated as the optimum distance between the two turbines. The result also shows that the upstream wind turbine has an obvious influence on the downstream one.

  18. Kur'an'daki İnfak Kavramının Anlam Yelpazesi

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    Ali Rıza Gül

    2015-11-01

    Full Text Available The conception of infâq conveys a wide range of meanings embracing many different conceptions elaborated within the Koran. Infâq is attributed both to Allah -in its metaphorical meaning- and the human beings. The meaning attributed to Allah is understood as granting mankind material subservience. However the meaning attributed to human beings is understood as disposing of the possessed thing and spending them both for themselves and the others, helping the other, based on its lexical meaning. As for the infâq done by the Muslims, together with this lexical meaning is named as zakât (obligatory alms, alms, helping, material contribution to war (provided that it is in the path to Allah, nafaqah, teberru. In addition to all these, the material support provided by the disbelievers in order to destroy Islam and the Muslims, the helps and contributions made by hypocrites (munâfiqûn to Islam’s army -though they are not good intentions- are assessed in the Koran within the work of infâq

  19. Memahami Makna-Makna Simbolik Pada Upacara Adat Sedekah Laut di Desa Tanjungan Kecamatan Kragan Kabupaten Rembang

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    Muhammad Abdurrohman

    2016-03-01

    Full Text Available This study aims to determine the meanings contained in the sequence of the ceremonial procession in the village of Sea Alms Tanjungan as an annual tradition organized by the local community. Theory basis used is the symbol by Susanne Langer's theory which states that a symbol or set of symbols works by connecting a concept, the general idea, pattern, or shape. Symbols are human conceptualization of a thing, there is a symbol for something. Research methods in use is descriptive qualitative, by describing the results that have been obtained from observation and depth interviews with informants. Results in the can that is symbolic ceremonies Sea Alms is a form of implementation of gratitude local community to God Almighty for the gift that has been given, as well as their respect to guard the sea are believed during this important role for the safety of the villagers Tanjungan. This research linkages with communication studies is that people can establish a value of life by applying them in the form of symbols that can be agreed upon by the perpetrators so as to form a culture.

  20. Pemikiran Quraish Shihab Tentang Ayat-Ayat Ekonomi

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    Muhammad Iswadi

    2013-12-01

    Full Text Available This study was conducted to examine further the commentary of economy passages Quraish Shihab’s work and the thoughts position of Quraish Shihab among other Islamic economic thoughts. This study outlines two theories, namely, (1 theory of economic study; and (2 paradigms and methods of interpretation. Based on the paradigms and methods of interpretation in a social science, economic passage commentary conducted by Quraish Shihab using maudhu’I method is categorized in the social definition paradigm that means contextual and functional commentary. Generally, Islamic economic thoughts of Quraish Shihab belongs to the Islamic economic study in the normative scope which means to the efforts to explain basic philosophy or normative of an economic study which is based on the Islamic guidance referring to the standard guidelines of Qur’an and Hadith. However, in a certain aspect, Quraish Shihab’s thoughts is different from that of mainstream Islamic economic thoughts particularly related to the interpretation of usury which is related to the interest. Quraish Shihab is inclined to think that interest is not the same as usury. However, Quraish Shihab has almost the same thoughts as the mainstream Islamic economic thoughts in terms of Islam and development issues, poverty, alms and alms amyl.

  1. Application of the small punch test to determine the fatigue properties of additive manufactured aerospace alloys

    Directory of Open Access Journals (Sweden)

    Lancaster Robert

    2018-01-01

    Full Text Available Additive layer manufacturing (ALM processes are becoming increasingly prevalent in the aerospace industry as design engineers look to profit from the numerous advantages that these advanced techniques can offer. However, given the safety critical nature and arduous operating conditions to which these components will be exposed to whilst in service, it is essential that the mechanical properties of such structures are fully understood. Transient microstructures are a typical characteristic of ALM components and resulting from the thermal cycles that occur during the build operation. Those microstructures make any mechanical assessment an involved procedure when assessing the process variables for any given parameter set. A useful mechanical test technique is small-scale testing, in particular, the small punch (SP test. SP testing is capable of localised sampling of a larger scale component and presents an attractive option to mechanically assess complex parts with representative geometries, that would not be possible using more conventional uniaxial test approaches. This paper will present the recent development of a small-scale testing methodology capable of inducing fatigue damage and a series of novel tests performed on different variants of Ti-6Al-4V.

  2. THE ROLE OF ARTICLE LEVEL METRICS IN SCIENTIFIC PUBLISHING

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    Vladimir TRAJKOVSKI

    2016-04-01

    Full Text Available Emerging metrics based on article-level does not exclude traditional metrics based on citations to the journal, but complements them. Article-level metrics (ALMs provide a wide range of metrics about the uptake of an individual journal article by the scientific community after publication. They include citations, statistics of usage, discussions in online comments and social media, social bookmarking, and recommendations. In this editorial, the role of article level metrics in publishing scientific papers has been described. Article-Level Metrics (ALMs are rapidly emerging as important tools to quantify how individual articles are being discussed, shared, and used. Data sources depend on the tool, but they include classic metrics indicators depending on citations, academic social networks (Mendeley, CiteULike, Delicious and social media (Facebook, Twitter, blogs, and Youtube. The most popular tools used to apply this new metrics are: Public Library of Science - Article-Level Metrics, Altmetric, Impactstory and Plum Analytics. Journal Impact Factor (JIF does not consider impact or influence beyond citations count as this count reflected only through Thomson Reuters’ Web of Science® database. JIF provides indicator related to the journal, but not related to a published paper. Thus, altmetrics now becomes an alternative metrics for performance assessment of individual scientists and their contributed scholarly publications. Macedonian scholarly publishers have to work on implementing of article level metrics in their e-journals. It is the way to increase their visibility and impact in the world of science.

  3. Early regulation of axolotl limb regeneration.

    Science.gov (United States)

    Makanae, Aki; Satoh, Akira

    2012-10-01

    Amphibian limb regeneration has been studied for a long time. In amphibian limb regeneration, an undifferentiated blastema is formed around the region damaged by amputation. The induction process of blastema formation has remained largely unknown because it is difficult to study the induction of limb regeneration. The recently developed accessory limb model (ALM) allows the investigation of limb induction and reveals early events of amphibian limb regeneration. The interaction between nerves and wound epidermis/epithelium is an important aspect of limb regeneration. During early limb regeneration, neurotrophic factors act on wound epithelium, leading to development of a functional epidermis/epithelium called the apical epithelial cap (AEC). AEC and nerves create a specific environment that inhibits wound healing and induces regeneration through blastema formation. It is suggested that FGF-signaling and MMP activities participate in creating a regenerative environment. To understand why urodele amphibians can create such a regenerative environment and humans cannot, it is necessary to identify the similarities and differences between regenerative and nonregenerative animals. Here we focus on ALM to consider limb regeneration from a new perspective and we also reported that focal adhesion kinase (FAK)-Src signaling controlled fibroblasts migration in axolotl limb regeneration. Copyright © 2012 Wiley Periodicals, Inc.

  4. Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania major vaccines in a rhesus monkey (Macaca mulatta model of the human disease

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    VF Amaral

    2002-10-01

    Full Text Available We have compared the efficacy of two Leishmania (Leishmania major vaccines, one genetically attenuated (DHFR-TS deficient organisms, the other inactivated [autoclaved promastigotes (ALM with bacillus Calmete-Guérin (BCG], in protecting rhesus macaques (Macaca mulatta against infection with virulent L. (L. major. Positive antigen-specific recall proliferative response was observed in vaccinees (79% in attenuated parasite-vaccinated monkeys, versus 75% in ALM-plus-BCG-vaccinated animals, although none of these animals exhibited either augmented in vitro gamma interferon (IFN-g production or positive delayed-type hypersensitivity (DTH response to the leishmanin skin test prior to the challenge. Following challenge, there were significant differences in blastogenic responses (p < 0.05 between attenuated-vaccinated monkeys and naïve controls. In both vaccinated groups very low levels of antibody were found before challenge, which increased after infective challenge. Protective immunity did not follow vaccination, in that monkeys exhibited skin lesion at the site of challenge in all the groups. The most striking result was the lack of pathogenicity of the attenuated parasite, which persisted in infected animals for up to three months, but were incapable of causing disease under the conditions employed. We concluded that both vaccine protocols used in this study are safe in primates, but require further improvement for vaccine application.

  5. Evaluation of the Benefits Attributable to Automotive Lightweight Materials Program Research and Development Projects; TOPICAL

    International Nuclear Information System (INIS)

    Das, S

    2001-01-01

    The purpose of this project is to identify and test methods appropriate for estimating the benefits attributable to research and development (R and D) projects funded by the Automotive Lightweight Materials (ALM) Program of the Office of Advanced Automotive Technologies (OAAT) of the U.S. Department of Energy (DOE). Funded projects range from basic materials science research to applied research in production environments. Collaborators on these projects include national laboratories, universities, and private sector firms, such as leading automobile manufacturers and their suppliers. Three ALM R and D projects were chosen for this pilot evaluation: Low-Cost, Continuous Cast Aluminum Sheet; Advanced Forming Technologies for Aluminum; and Manufacturing of Composite Automotive Structures. These projects were chosen because they represent a range of benefits evaluation situations. The first project resulted in an improved process that may be commercialized. The second project is on going and has two distinct components. The third project has yielded an improved technology that has been commercialized. This completed project also benefited from numerous complementary projects

  6. Sparse time-frequency decomposition based on dictionary adaptation.

    Science.gov (United States)

    Hou, Thomas Y; Shi, Zuoqiang

    2016-04-13

    In this paper, we propose a time-frequency analysis method to obtain instantaneous frequencies and the corresponding decomposition by solving an optimization problem. In this optimization problem, the basis that is used to decompose the signal is not known a priori. Instead, it is adapted to the signal and is determined as part of the optimization problem. In this sense, this optimization problem can be seen as a dictionary adaptation problem, in which the dictionary is adaptive to one signal rather than a training set in dictionary learning. This dictionary adaptation problem is solved by using the augmented Lagrangian multiplier (ALM) method iteratively. We further accelerate the ALM method in each iteration by using the fast wavelet transform. We apply our method to decompose several signals, including signals with poor scale separation, signals with outliers and polluted by noise and a real signal. The results show that this method can give accurate recovery of both the instantaneous frequencies and the intrinsic mode functions. © 2016 The Author(s).

  7. A fully integrated optical detector with a-Si:H based color photodiodes

    Energy Technology Data Exchange (ETDEWEB)

    Watty, Krystian; Merfort, Christian; Seibel, Konstantin; Schoeler, Lars; Boehm, Markus [Institute for Microsystem Technologies (IMT), University of Siegen, Hoelderlinstr. 3, 57076 Siegen (Germany)

    2010-03-15

    The fabrication of an electrophoresis separation microchip with monolithic integrated excitation light source and variospectral photodiodes for absorption detection is presented in this paper. Microchip based separation techniques are essential elements in the development of fully integrated micro-total analysis systems ({mu}-TAS). An integrated microfluidic device, like an application specific lab-on-microchip (ALM) (Seibel et al., in: MRS Spring Meeting, San Francisco, USA, 2005 1), includes all components, necessary to perform a chemical analysis on chip and it can be used as a stand-alone unit directly at the point of sampling. Variospectral diodes based on hydrogenated amorphous silicon (a-Si:H) technology allow for advanced optical detection schemes, because the spectral sensitivity of the devices can be tailored to fit the emission of specific fluorescent markers. Important features of a-Si:H variospectral photodiodes are a high dynamic range, a bias-tunable spectral sensitivity and a very good linearity for the separation of mixed color signals. Principle of ALM device. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  8. Magnesium isotopes: a tool to understand self-enrichment in globular clusters

    Science.gov (United States)

    Ventura, P.; D'Antona, F.; Imbriani, G.; Di Criscienzo, M.; Dell'Agli, F.; Tailo, M.

    2018-06-01

    A critical issue in the asymptotic giant branch (AGB) self-enrichment scenario for the formation of multiple populations in globular clusters (GCs) is the inability to reproduce the magnesium isotopic ratios, despite the model in principle can account for the depletion of magnesium. In this work, we analyse how the uncertainties on the various p-capture cross sections affect the results related to the magnesium content of the ejecta of AGB stars. The observed distribution of the magnesium isotopes and of the overall Mg-Al trend in M13 and NGC 6752 are successfully reproduced when the proton-capture rate by 25Mg at the temperatures ˜100 MK, in particular the 25Mg(p, γ)26Alm channel, is enhanced by a factor ˜3 with respect to the most recent experimental determinations. This assumption also allows us to reproduce the full extent of the Mg spread and the Mg-Si anticorrelation observed in NGC 2419. The uncertainties in the rate of the 25Mg(p, γ)26Alm reaction at the temperatures of interest here leave space for our assumption and we suggest that new experimental measurements are needed to settle this problem. We also discuss the competitive model based on the supermassive star nucleosynthesis.

  9. P-T-t metamorphic evolution of highly deformed metapelites from the Pinkie unit of western Svalbard using quartz-in-garnet barometry, trace element thermometry, P-T-X-M diagrams and monazite in-situ dating

    Science.gov (United States)

    Kośmińska, Karolina; Spear, Frank; Majka, Jarosław

    2017-04-01

    We present the results of quartz-in-garnet (QuiG) Raman barometry coupled with P-T-X-M diagrams, trace element thermometry, and monazite dating from metapelites of the Pinkie unit on Prins Karls Forland, western Svalbard. This unconventional approach, which combines traditional and novel thermobarometry techniques as well as dating results, provides the opportunity to decipher the pressure-temperature-time (P-T-t) metamorphic evolution of these highly deformed rocks, for which the P-T conditions could not have been obtained using traditional techniques. The Pinkie unit is comprised of Barrovian-type zones expressed by the following three mineral assemblages: Grt+St+Ms+Bt+Pl+Q, Grt+St+Ky+Ms+Bt+Pl+Q and Grt+Ky+Ms+Bt+Pl+Q. The metamorphic assemblages have been strongly affected by pervasive mylonitization. Two generations of garnet are present. Early garnet-I forms large (up to 2 mm) anhedral and inclusion-rich porphyroblasts that are strongly deformed with resorbed rims. Its composition varies from Alm81Grs5Prp11Sps3 in the core to Alm84Grs4Prp10Sps2 in the rim for a St-bearing sample. St-Ky bearing metapelites contain garnet-I, which is characterized by Alm88Grs2Prp8Sps2 in the core and Alm89Grs2Prp8Sps1 in the rim. In the Ky-bearing sample garnet-I composition is varying from Alm77Grs4Prp11Sps8 in the core to Alm83Grs4Prp9Sps4 in the rim. Garnet-II is characterized by small (up to 0.5 mm) euhedral grains that locally overgrows garnet-I. It contains very scarce inclusions, mostly quartz. Grt-II composition is very similar in all Pinkie unit samples and is characterized by Alm80Grs11Prp8Sps1(0). The measured maximum shift of the 464 cm-1 Raman band for quartz in garnet-I is 1.05 cm-1 for St-bearing samples, 1.80 cm-1 for St-Ky bearing rocks, and 2.10 cm-1 for Ky-bearing samples, respectively. The highest shift obtained for inclusions in garnet-II is 2.7 cm-1. Monazite-in-garnet thermometry combined with the QuiG yielded P-T conditions of garnet-I nucleation as

  10. Comparison of Conventional, Trace Element, and Pseudosection Thermobarometry in UHP Eclogite, North Qaidam Terrane, Western China

    Science.gov (United States)

    Mattinson, C. G.; Regel, M. E.; Zhang, J.

    2014-12-01

    In the southeastern North Qaidam terrane, near Dulan, felsic host gneisses enclose minor eclogite lenses. A small (~3°C/km) increase in temperatures to the west based on Zr-in-Rt thermometry is supported by a textural trend of zoned garnet with prograde mineral inclusions in the west to unzoned garnet with only peak-stage inclusions in the east. A western eclogite sample contains minor Ep and trace Phe in addition to Grt-Omp-Qtz-Rt; a strong foliation is defined by banding of Grt and Omp. Garnet Ca falls significantly from core (Alm44Prp23Grs32) to rim (Alm48Prp27Grs23). Phengite contains 3.34-3.36 Si pfu. Conventional Grt-Omp-Phe thermobarometry yields 23-27 kbar, 660-730°C, and Zr-in-Rt thermometry yields 671 ± 9°C (n = 37). An isochemical phase diagram (pseudosection) for the system NCKFMASHO calculated with PerpleX indicates that garnet Xgrs decreases with increasing P and T, suggesting that observed garnet zoning reflects prograde growth. Garnet rim compositional isopleths intersect at 23-27 kbar, 580-620°C, depending on choice of effective bulk composition and assumed Fe3+/Fetotal. Garnet rims help define the foliation, suggesting that these P-T conditions apply to this deformation. An eastern eclogite sample contains minor Ep and abundant, coarse-grained Phe in addition to Grt-Omp-Qtz-Rt; foliation is weak. Garnet zoning is weak; compositions are Alm41-43Prp26-28Grs29-32. Phengite cores contain 3.48-3.56 Si pfu. Conventional Grt-Omp-Phe thermobarometry yields 32-36 kbar, 700-750°C, and Zr-in-Rt thermometry yields 691 ± 12°C (n = 34). Conventional thermobarometry and pseudosections yield similar peak P-T conditions, but from different mineral compositions: thermobarometry yields peak P from high-Ca Grt, but the pseudosection yields peak P from intermediate-Ca Grt; maximum Ca in Grt is predicted at lower P and T. Pseudosection-based peak Ts are significantly lower than those from Zr-in-Rt and conventional thermometry. Wide isopleth spacing in the

  11. Model of a Piezoelectric Transducer

    Science.gov (United States)

    Goodenow, Debra

    2004-01-01

    It's difficult to control liquid and gas in propellant tanks in zero gravity. A possible a design would utilize acoustic liquid manipulation (ALM) technology which uses ultrasonic beams conducted through a liquid and solid media, to push gas bubbles in the liquid to desirable locations. We can propel and control the bubble with acoustic radiation pressure by aiming the acoustic waves on the bubble s surface. This allows us to design a so called smart tank in which the ALM devices transfer the gas to the outer wall of the tank and isolating the liquid in the center. Because the heat transfer rate of a gas is lower of that of the liquid it would substantially decrease boil off and provide of for a longer storage life. The ALM beam is composed of little wavelets which are individual waves that constructively interfere with each other to produce a single, combined acoustic wave front. This is accomplished by using a set of synchronized ultrasound transducers arranged in an array. A slight phase offset of these elements allows us to focus and steer the beam. The device that we are using to produce the acoustic beam is called the piezoelectric transducer. This device converts electrical energy to mechanical energy, which appears in the form of acoustic energy. Therefore the behavior of the device is dependent on both the mechanical characteristics, such as its density, cross-sectional area, and its electrical characteristics, such as, electric flux permittivity and coupling factor. These devices can also be set up in a number of modes which are determined by the way the piezoelectric device is arranged, and the shape of the transducer. For this application we are using the longitudinal or thickness mode for our operation. The transducer also vibrates in the lateral mode, and one of the goals of my project is to decrease the amount of energy lost to the lateral mode. To model the behavior of the transducers I will be using Pspice, electric circuit modeling tool, to

  12. Health risk assessments of heavy metal exposure via consumption of marine mussels collected from anthropogenic sites

    International Nuclear Information System (INIS)

    Yap, Chee Kong; Cheng, Wan Hee; Karami, Ali; Ismail, Ahmad

    2016-01-01

    A total of 40 marine mussel Perna viridis populations collected (2002–2009) from 20 geographical sites located in two busy shipping lanes namely the Straits of Malacca (10 sites; 16 populations) and the Straits of Johore (8 sites; 21 populations) and three populations (2 sites) on the east coast of Peninsular Malaysia, was determined for Cd, Cu, Fe, Ni, Pb and Zn concentrations. In comparison with the maximum permissible limits (MPLs) set by existing food safety guidelines, all metal concentrations found in all the mussel populations were lower than the prescribed MPLs. In terms of the provisional tolerable weekly intake prescribed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and oral reference doses (ORDs) by the USEPA, all the studied metals (except for Pb) were unlikely to become the limiting factors or unlikely to pose a risk for the consumption of the mussel populations. The estimated daily intake (EDI) for average level mussel (ALM) and high level mussel (HLM) consumers of mussels was found to be lower than the ORD guidelines for Cd, Cu, Fe, Ni and Zn. Furthermore, the target hazard quotient (THQ) was found to be less than 1 for ALM consumers but higher than 1 for HLM consumers in some sites. Therefore, there were no potential human health risks to the ALM consumers of the mussels. However, for Pb THQ values, the Pb levels in some mussel populations could create a health risk problem. Present results indicate that the consumption amounts of mussels should be limited for minimizing potential health risks of heavy metals to the HLM consumers. - Highlights: • Human health risk assessments of heavy metals in Perna viridis were investigated. • All metals in the mussels were below the established seafood safety guidelines. • Pb in mussels could easily reach the percentage of prescribed PTWI value of Pb. • Potential health risk with Pb exposure was found for the mussel consumers. • Consumption rate of mussels should be limited to

  13. Health risk assessments of heavy metal exposure via consumption of marine mussels collected from anthropogenic sites

    Energy Technology Data Exchange (ETDEWEB)

    Yap, Chee Kong, E-mail: yapckong@hotmail.com [Department of Biology, Faculty of Science, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia); Cheng, Wan Hee [Inti International University, Persiaran Perdana BBN, 71800 Nilai, Negeri Sembilan (Malaysia); Karami, Ali [Laboratory of Aquatic Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia); Ismail, Ahmad [Department of Biology, Faculty of Science, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia)

    2016-05-15

    A total of 40 marine mussel Perna viridis populations collected (2002–2009) from 20 geographical sites located in two busy shipping lanes namely the Straits of Malacca (10 sites; 16 populations) and the Straits of Johore (8 sites; 21 populations) and three populations (2 sites) on the east coast of Peninsular Malaysia, was determined for Cd, Cu, Fe, Ni, Pb and Zn concentrations. In comparison with the maximum permissible limits (MPLs) set by existing food safety guidelines, all metal concentrations found in all the mussel populations were lower than the prescribed MPLs. In terms of the provisional tolerable weekly intake prescribed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and oral reference doses (ORDs) by the USEPA, all the studied metals (except for Pb) were unlikely to become the limiting factors or unlikely to pose a risk for the consumption of the mussel populations. The estimated daily intake (EDI) for average level mussel (ALM) and high level mussel (HLM) consumers of mussels was found to be lower than the ORD guidelines for Cd, Cu, Fe, Ni and Zn. Furthermore, the target hazard quotient (THQ) was found to be less than 1 for ALM consumers but higher than 1 for HLM consumers in some sites. Therefore, there were no potential human health risks to the ALM consumers of the mussels. However, for Pb THQ values, the Pb levels in some mussel populations could create a health risk problem. Present results indicate that the consumption amounts of mussels should be limited for minimizing potential health risks of heavy metals to the HLM consumers. - Highlights: • Human health risk assessments of heavy metals in Perna viridis were investigated. • All metals in the mussels were below the established seafood safety guidelines. • Pb in mussels could easily reach the percentage of prescribed PTWI value of Pb. • Potential health risk with Pb exposure was found for the mussel consumers. • Consumption rate of mussels should be limited to

  14. Cross-flow turbines: physical and numerical model studies towards improved array simulations

    Science.gov (United States)

    Wosnik, M.; Bachant, P.

    2015-12-01

    Cross-flow, or vertical-axis turbines, show potential in marine hydrokinetic (MHK) and wind energy applications. As turbine designs mature, the research focus is shifting from individual devices towards improving turbine array layouts for maximizing overall power output, i.e., minimizing wake interference for axial-flow turbines, or taking advantage of constructive wake interaction for cross-flow turbines. Numerical simulations are generally better suited to explore the turbine array design parameter space, as physical model studies of large arrays at large model scale would be expensive. However, since the computing power available today is not sufficient to conduct simulations of the flow in and around large arrays of turbines with fully resolved turbine geometries, the turbines' interaction with the energy resource needs to be parameterized, or modeled. Most models in use today, e.g. actuator disk, are not able to predict the unique wake structure generated by cross-flow turbines. Experiments were carried out using a high-resolution turbine test bed in a large cross-section tow tank, designed to achieve sufficiently high Reynolds numbers for the results to be Reynolds number independent with respect to turbine performance and wake statistics, such that they can be reliably extrapolated to full scale and used for model validation. To improve parameterization in array simulations, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier--Stokes models. The ALM predicts turbine loading with the blade element method combined with sub-models for dynamic stall and flow curvature. The open-source software is written as an extension library for the OpenFOAM CFD package, which allows the ALM body force to be applied to their standard RANS and LES solvers. Turbine forcing is also applied to volume of fluid (VOF) models, e.g., for predicting free surface effects on submerged MHK devices. An

  15. Özgün İslami Finansal Kurumlar İnşa Etmek

    Directory of Open Access Journals (Sweden)

    Asad Zaman Çeviren: Mustafa Kenan ERKAN

    2016-11-01

    Full Text Available Özet İslam’ın ruhunun kapitalizmin ruhuyla sert ve keskin bir uyuşmazlık içinde olmasından dolayı, İslam’ın ruhunu ifade etmek üzere tasarlanmış kurumların almış olduğu biçimin de ayrıca farklı olması zorunludur. Kapitalist finansal kurumlar kapitalist toplumların özünde yer alan servet biriktirme sürecini desteklemek üzere tasarlanmışlardır. İslam’da esas olan, kapitalist toplumlarda baskın olanlardan radikal bir şekilde farklı çeşitli hizmet-odaklı kurumlardaki hizmet ruhu ve başkalarına infak etmektir.

  16. A Generalized Robust Minimization Framework for Low-Rank Matrix Recovery

    Directory of Open Access Journals (Sweden)

    Wen-Ze Shao

    2014-01-01

    Full Text Available This paper considers the problem of recovering low-rank matrices which are heavily corrupted by outliers or large errors. To improve the robustness of existing recovery methods, the problem is solved by formulating it as a generalized nonsmooth nonconvex minimization functional via exploiting the Schatten p-norm (0 < p ≤1 and Lq(0 < q ≤1 seminorm. Two numerical algorithms are provided based on the augmented Lagrange multiplier (ALM and accelerated proximal gradient (APG methods as well as efficient root-finder strategies. Experimental results demonstrate that the proposed generalized approach is more inclusive and effective compared with state-of-the-art methods, either convex or nonconvex.

  17. STUDY UPON THE MACROZOOBENTHIC COMMUNITIES FROM THE DANUBE RIVER BY BAZIAŞ-PORŢILE DE FIER SECTOR (SOUTH-WESTERN ROMANIA

    Directory of Open Access Journals (Sweden)

    ADINA-MIRELA PANĂ

    2009-01-01

    Full Text Available Different sensitivity of benthic macroinvertebrates was used in determining water quality of the eight major tributaries of the Danube, which drains two mountain ranges: Locvei and Almăjului, within the context in which the macrozoobenthic community is influenced by changes in the qualitative parameters of aquatic ecosystems. To get an overview, a series of physical- chemical parameters (water temperature, pH, oxygen, conductivity, cyanide, nitrites, nitrates, phosphates was studied in parallel with the study of benthic community. Elevated abundance of benthic groups in the case of water quality characteristic (Ephemeroptera, Trichoptera, Plecoptera, Amphipoda, along with their high frequency in all the monitored tributaries in the present study and the water quality parameters maintained within normal limits fits these lotic ecosystems in the A class of surface water quality.

  18. ÜRETİM VE HİZMET İŞLETMELERİ AÇISINDAN YÖNETİM VE ORGANİZASYON YAKLAŞIMLARINA TOPLU BİR BAKIŞ (KLASİK-NEOKLASİK-MODERN-NEOMODERN YAKLAŞIMLAR)

    OpenAIRE

    Türengül, M.

    2018-01-01

    Globalleşme ile birlikte yönetim ve organizasyon yaklaşımları uygulamada önem kazanmış olup, işletmeler, belirledikleri stratejilere göre ve piyasa (Pazar) koşullarını da göz önünde bulundurarak en uygun yaklaşıma uygulamada yer vermişlerdir. Klasik yaklaşım, neoklasik yaklaşım, modern yaklaşım özelliklede koşulsallık yaklaşımı neo-modern yaklaşım uygulamada yer almıştır.

  19. Development of Hi-Tech ceramics fabrication technologies - Development of advanced nuclear materials

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Thae Kap; Park, Ji Youn; Kim, Sun Jae; Kim, Kyong Ho; Jung, Choong Hwan; Oh, Seok Jin [Korea Atomic Energy Res. Inst., Taejon (Korea, Republic of)

    1994-07-15

    The objective of the present work is to prepare the foundation of hi-tech ceramics fabrication technologies through developing important processes i.e., tape casting, sol-gel, single crystal growing, compacting and sintering, and grinding and machining processes. Tape casting process is essential to manufacture hard and functional thin plates and structural elements for some composite materials. For the fabrication of spherical mono-sized micropowders of oxides, sol-gel process has widely been used. Piezoelectric elements that are the core parts of the sensors of LPMS (loose part monitoring system) and ALMS (acoustic leakage monitoring system) are used in single crystal forms. Compacting and sintering processes are general methods for fabricating structural parts using powders. Grinding and machining processes are important to achieve the final dimensions and surface properties of the parts. (Author).

  20. An augmented Lagrangian multi-scale dictionary learning algorithm

    Directory of Open Access Journals (Sweden)

    Ye Meng

    2011-01-01

    Full Text Available Abstract Learning overcomplete dictionaries for sparse signal representation has become a hot topic fascinated by many researchers in the recent years, while most of the existing approaches have a serious problem that they always lead to local minima. In this article, we present a novel augmented Lagrangian multi-scale dictionary learning algorithm (ALM-DL, which is achieved by first recasting the constrained dictionary learning problem into an AL scheme, and then updating the dictionary after each inner iteration of the scheme during which majorization-minimization technique is employed for solving the inner subproblem. Refining the dictionary from low scale to high makes the proposed method less dependent on the initial dictionary hence avoiding local optima. Numerical tests for synthetic data and denoising applications on real images demonstrate the superior performance of the proposed approach.

  1. Questes de mtodo: Aspectos da prtica de pesquisa em internet Method issues: practical aspects of Internet research

    Directory of Open Access Journals (Sweden)

    Simone Bueno da Silva

    2012-01-01

    Full Text Available O livro Mtodos de pesquisa para internet aborda perspectivas metodolgicas para a pesquisa emprica na comunicao digital, alm de oferecer elementos para discusses centradas na internet ou que a utilizem como instrumento de pesquisa. Partindo da vivncia das pesquisadoras, debate, a partir de uma perspectiva crtica, estratgias metodolgicas que buscam otimizar a coleta e anlise de dados, tratados em relao com a iluminao do problema de pesquisa e perspectivas tericas.The book Research methods for internet approaches methodological perspectives for empirical research in digital communications, besides offering elements for discussions centered on the internet or that use it as a research instrument. Based on the experience of researchers, describes and discusses, from a critical perspective, methodological strategies to optimize the collection and analysis of data, treated in relation with the revealing of the research problem and theoretical perspectives.

  2. Peregrinos e viajantes no Norte de Portugal : as esmolas distribuídas pela ordem terceira franciscana de Braga aos irmãos «passageiros» (1720-1816

    Directory of Open Access Journals (Sweden)

    Juliana de Mello Moraes

    2010-01-01

    Full Text Available During the 18th century many people came to Braga as travellers or pilgrims. In this town they found several institutions, some of which helped the travellers materially and spiritually, such as the Third Order of Saint Francis. Based on this Order’s records, it was possible to draw a profile of those who sought out the secular order for help. At the same time, this information allowed us to analyze, from a quantitative and qualitative perspective, some relevant characteristics of travellers in northern Portugal during that period. Besides the specifics of those whom the brothers assisted, this paper also evaluates the management of this activity, that of the distribution of alms, by the secular Franciscans of Braga, revealing a welfare practice that is practically unknown in current historiography.

  3. As armas dos cristãos

    Directory of Open Access Journals (Sweden)

    Angelica Hoffler

    2002-01-01

    Full Text Available In this paper, we analyse Juazeiro do Norte particularly considering the belief that the End do the World is about to happen and the need of having their sins forgiven, Man, pilgrim in this world, takes advantage of the weapons offered by the Holy Writ and by the Compassion Books to fight against the eternal enemy. They are: the alms, the fasting, the prayer, the humiliation. / Diante da crença na iminência do Fim dos Tempos e da necessidade de remissão dos pecados, o Homem, peregrino sobre este mundo vale-se das armas que lhe são fornecidads pelas Escrituras e pelos Manuais de Piedade para combater o inimigo eterno. São elas: a esmola, o jejum, a oração, a mortificação.

  4. THE DEVELOPMENT OF INDONESIAN ISLAMIC LAW: A Historical Overview

    Directory of Open Access Journals (Sweden)

    Ahmad Yasa

    2015-06-01

    Full Text Available Islamic Law is a set of promoted regulations adjusting human relationship to the Creator, human being and the environment based on Islamic doctrines. The Islamic Law has been established in Indonesia and effectively implemented in Indonesian Religious Court based on Law Number 7 of 1989. The law covers the areas of marriage, inheritance, will, bequest, benefaction and alms. In addition, especially in Aceh, with its peculiar feature, Islamic Law has been applied normatively, and in several areas it has been applied based on Local Regulations. However to perform the Islamic Law, it depends on faith and piety of the members of Islam. Thereby, although the formal law in juridical manner of Islamic Law in Indonesia was justly applied in limited civil law, however the Muslim society have stepped forward in applying Islamic Law in various Islamic social institutions.

  5. Congratulations on the direct detection of gravitational waves

    CERN Multimedia

    2016-01-01

    This week saw the announcement of an extraordinary physics result: the first direct detection of gravitational waves by the LIGO Scientific Collaboration, which includes the GEO team, and the Virgo Collaboration, using the twin Laser Interferometer Gravitational-wave Observatory (LIGO) detectors located in Livingston, Louisiana, and Hanford, Washington, USA.   Albert Einstein predicted gravitational waves in a paper published 100 years ago in 1916. They are a natural consequence of the theory of general relativity, which describes the workings of gravity and was published a few months earlier. Until now, they have remained elusive. Gravitational waves are tiny ripples in space-time produced by violent gravitational phenomena. Because the fractional change in the space-time geometry can be at the level of 10-21 or smaller, extremely sophisticated, high-sensitivity instruments are needed to detect them. Recently, the Advanced LIGO detector increased its sensitivity by alm...

  6. Military Standard Generators Prototype Modifications. Volume 2. 30 kW DoD Generator Set

    Science.gov (United States)

    1988-03-31

    GE14 SET S,./14 KZO 5EJ41 70 KM,,*68 ý0 GEN S¢ET SIRN tɘ 5841 C 1 EXHAUST ± 484.71 DEG. F C I EXHAUST ± 545. 67 DEG. F C 2 EXHAUST 2 473.2-9 DEG. F...584t ý󈧣 Kid.- N Z GE14 SET SoN K20 584 ±i EXHAUST ± 85.64 bEG. F C. EXHAUST 1 062.12 DEG. F C 2 EXHAUSIT 2 75854 PEG.F C 2 EXHAUST 2 7M2± DEG. F c 7...E: 2ŗ GE14 . UVLT. P.RG. 78. 165 DEIG. F AL". C 23 GEN. UDLT. RIG. 69..945 DEG. F AL? C: 24 r:D[4TROL PANEL 68S.7 35% DEG. F ALM! C 24 CO4TRTOL PANEL

  7. Colestase neonatal - Protocolo de abordagem diagnóstica

    OpenAIRE

    Santos Silva, Ermelinda; Pó, Inês; Gonçalves, Isabel

    2014-01-01

    A icterícia é frequente nos recém nascidos. A persistência de icterícia para além dos 14 dias de vida (em recém-nascidos de termo) torna mandatória uma investigação, embora muitos bebés com icterícia do leite materno se possam manter ictéricos para além dos 30 dias 1.A ictercia frequente nos recm nascidos. A persistncia de ictercia para alm dos 14 dias de vida (em recm-nascidos de termo) torna mandatria uma investigao, embora muitos bebs com ictercia do leite materno se possam manter ictricos...

  8. How dentists diagnose and treat defective restorations: evidence from the dental practice-based research network

    DEFF Research Database (Denmark)

    Gordan, Valeria V; Garvan, Cynthia W; Richman, Joshua S

    2009-01-01

    , Norway and Sweden. METHODS: A questionnaire was sent to all DPBRN practitioner-investigators who reported doing some restorative dentistry (n = 901). Questions included clinical case scenarios that used text and clinical photographs of defective restorations. Dentists were asked what type of treatment......OBJECTIVES: To (1) identify and quantify the types of treatment that dentists use to manage defective dental restorations and (2) identify characteristics that are associated with these dentists' decisions to replace existing restorations. The Dental Practice-Based Research Network (DPBRN) consists...... of dentists in outpatient practices from five regions: AL/MS: Alabama/Mississippi; FL/GA: Florida/Georgia; MN: dentists employed by HealthPartners and private practitioners in Minnesota; PDA: Permanente Dental Associates in cooperation with Kaiser Permanente's Center for Health Research and SK: Denmark...

  9. ÖĞRETMENLERİN SERBEST ZAMAN EĞİTİMİ VE REKREASYON (SERBEST ZAMANDA YAPILAN AKTİVİTELER) ETKİNLİKLERİNE KATILIMLARINDAKİ SOSYO, EKONOMİK, KÜLTÜREL ETKENLER- DÜZCE ÖRNEĞİ

    OpenAIRE

    AŞKIN, Cevdet

    2016-01-01

    Serbest zaman etkinliklerinin başarı ve verimlilik süreci olarak düşünülmesinin ülke gelişimine katkısı son yıllarda önemli derecede kabul görmüştür. Eğitim-öğretim sahasında, geleneksel metodların yerini teknolojik gelişmeler almıştır. Her yerde, her zaman, her durumda eğitimin sürdürülmesi öğretmenlerimizin kendilerinde farklı bir rol üstlenmesi gerektiği düşünülmektedir. Eğitim-öğretimin ana unsuru olan öğretmenlerin serbest zamanlarını iyi bir şekilde değerlendirmeleri iş verimliliğini mü...

  10. 3D printing for construction: a procedural and material-based approach

    Directory of Open Access Journals (Sweden)

    A. Nadal

    2017-06-01

    Full Text Available 3D printing for construction is stagnated at an early stage of development, especially regarding material optimization and procedural issues. These limitations are due to the specific knowledge that these technologies imply, the total cost of the machinery involved, and the lack of clear procedural guidelines. This paper presents a methodology that aims at overcoming these limitations through a workflow that allows for the ease of use of 6-axis robotic arms. A technique for the optimization of material usage is presented. A test case that shows the integration the design-to-fabrication process combining Integrated Robotic Systems (IRS and Additive Layer Manufacturing (ALM techniques is discussed. A structure-based approach to material optimization and smart infill patterning is introduced. A 0.4 x 0.4 x 1.5 m test part is shown as technological demonstrator.

  11. FREDERICK WINSLOW TAYLOR VE FİZYOLOJİK ÖRGÜT KURAMI

    OpenAIRE

    ASUNAKUTLU, Tuncer; COŞKUN, Bayram

    2005-01-01

    Bilimsel Yönetimin İlkeleri (The Principles of Scientific Management) adlı eserin yayınlanması yönetim tarihi açısından bir dönüm noktası kabul edilmektedir. Bilimsel anlamda yönetimi ilk kez ele alan ve analiz eden bu eser yayınlandığında çok önemli etkiler yaratmıştır. Bu eserin sahibi yönetim bilimi tarihinde önemli bir yeri olan F.W.Taylor’dur. Bu çalışma Taylor’un kişilik özellikleri ile geliştirdiği kuramı bütünsel olarak incelemek ve bu teorinin almış olduğu eleştirileri açıklamak amac...

  12. Time-separated oscillatory fields for high-precision mass measurements on short-lived Al and Ca nuclides

    CERN Document Server

    George, Simon; Blank, B.; Blaum, K.; Breitenfeldt, M.; Hager, U.; Herfurth, F.; Herlert, A.; Kellerbauer, A.; Kluge, H.J.; Kretzschmar, M.; Lunney, D.; Savreux, R.; Schwarz, Andreas S.; Schweikhard, L.; Yazidjian, C.

    2008-01-01

    High-precision Penning trap mass measurements on the stable nuclide $^{27}$Al as well as on the short-lived radionuclides $^{26}$Al and $^{38,39}$Ca have been performed by use of radio-frequency excitation with time-separated oscillatory fields, i.e. Ramsey's method, as recently introduced for the excitation of the ion motion in a Penning trap, was applied. A comparison with the conventional method of a single continuous excitation demonstrates its advantage of up to ten times shorter measurements. The new mass values of $^{26,27}$Al clarify conflicting data in this specific mass region. In addition, the resulting mass values of the superallowed $\\beta$-emitter $^{38}$Ca as well as of the groundstate of the $\\beta$-emitter $^{26}$Al$^{m}$ confirm previous measurements and corresponding theoretical corrections of the ft-values.

  13. THE CONTRIBUTION OF THE EMPRESS MARIA FEODOROVNA INTO THE ORGANIZATION OF CHILDREN HEALTH CARE

    Directory of Open Access Journals (Sweden)

    G. L. Mikirtichan

    2013-01-01

    Full Text Available Sophie Marie Dorothea Auguste Louise descended from German House of Württemberg and was the eldest daughter of the prince Friedrich II Eugen, Duke of Württemberg. She turned into Orthodoxy under the name of Maria Feodorovna. In September 1776 she married the future emperor — Paul I. One of the most significant pages in the history of Russia is associated with the name of Maria Feodorovna — formation of the charity as a system, including three main directions: public education, social support and health care. With her direct assistance 30 charity institutions (founding hospitals, a number of women institutes and other teaching and educational organizations, alms-houses, hospitals etc. were founded, most of them — for children.

  14. A FPGA Implementation of the CAR-FAC Cochlear Model

    Directory of Open Access Journals (Sweden)

    Ying Xu

    2018-04-01

    Full Text Available This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC cochlear model. The CAR part simulates the basilar membrane's (BM response to sound. The FAC part models the outer hair cell (OHC, the inner hair cell (IHC, and the medial olivocochlear efferent system functions. The FAC feeds back to the CAR by moving the poles and zeros of the CAR resonators automatically. We have implemented a 70-section, 44.1 kHz sampling rate CAR-FAC system on an Altera Cyclone V Field Programmable Gate Array (FPGA with 18% ALM utilization by using time-multiplexing and pipeline parallelizing techniques and present measurement results here. The fully digital reconfigurable CAR-FAC system is stable, scalable, easy to use, and provides an excellent input stage to more complex machine hearing tasks such as sound localization, sound segregation, speech recognition, and so on.

  15. A FPGA Implementation of the CAR-FAC Cochlear Model.

    Science.gov (United States)

    Xu, Ying; Thakur, Chetan S; Singh, Ram K; Hamilton, Tara Julia; Wang, Runchun M; van Schaik, André

    2018-01-01

    This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear efferent system functions. The FAC feeds back to the CAR by moving the poles and zeros of the CAR resonators automatically. We have implemented a 70-section, 44.1 kHz sampling rate CAR-FAC system on an Altera Cyclone V Field Programmable Gate Array (FPGA) with 18% ALM utilization by using time-multiplexing and pipeline parallelizing techniques and present measurement results here. The fully digital reconfigurable CAR-FAC system is stable, scalable, easy to use, and provides an excellent input stage to more complex machine hearing tasks such as sound localization, sound segregation, speech recognition, and so on.

  16. Aggregative Learning Method and Its Application for Communication Quality Evaluation

    Science.gov (United States)

    Akhmetov, Dauren F.; Kotaki, Minoru

    2007-12-01

    In this paper, so-called Aggregative Learning Method (ALM) is proposed to improve and simplify the learning and classification abilities of different data processing systems. It provides a universal basis for design and analysis of mathematical models of wide class. A procedure was elaborated for time series model reconstruction and analysis for linear and nonlinear cases. Data approximation accuracy (during learning phase) and data classification quality (during recall phase) are estimated from introduced statistic parameters. The validity and efficiency of the proposed approach have been demonstrated through its application for monitoring of wireless communication quality, namely, for Fixed Wireless Access (FWA) system. Low memory and computation resources were shown to be needed for the procedure realization, especially for data classification (recall) stage. Characterized with high computational efficiency and simple decision making procedure, the derived approaches can be useful for simple and reliable real-time surveillance and control system design.

  17. Fe-Al2O3 nanocomposites prepared by high-energy ball milling

    DEFF Research Database (Denmark)

    Linderoth, Søren; Pedersen, M.S.

    1994-01-01

    Nanocomposites of alpha-Fe and alpha-Al2O3, prepared by high-energy ball milling, exhibit coercivities which are enhanced by about two orders of magnitude with respect to the bulk value. The degree of enhancement depends on the volume fraction (x(upsilon)) of Fe, with a maximum for x(upsilon) alm......Nanocomposites of alpha-Fe and alpha-Al2O3, prepared by high-energy ball milling, exhibit coercivities which are enhanced by about two orders of magnitude with respect to the bulk value. The degree of enhancement depends on the volume fraction (x(upsilon)) of Fe, with a maximum for x...

  18. Malignant melanoma misdiagnosed as diabetic foot ulcer: A case report.

    Science.gov (United States)

    Gao, Wei; Chen, Dawei; Ran, Xingwu

    2017-07-01

    Acral lentiginous melanoma (AML) does not exhibit the classic signs of malignant melanoma. ALM is frequently misdiagnosed because of its unusual sites and atypical clinical morphologies, which lead to poor prognosis. A female patient aged 78 years was presented to our center with two ulcers on her right foot. Diabetic foot ulcer was considered as the primary diagnosis. The ulcers failed to improve after 2 weeks' therapy. An incisional biopsy of the lesion revealed malignant melanoma. The patient received wide excision, skin grafting as well as biotherapy. The lesion was healed and no other metastasis has been founded until now. Clinicians must maintain a high level of suspicion in distinguishing malignant melanoma from other more benign skin lesions of the foot. The need for early biopsy of ulcer, even when clinical suspicion is low, can not be overemphasized. Only in this way can we reduce misdiagnosis rate and improve survival rate in patients with foot ulcer.

  19. Türkiye Cumhuriyeti’nin İlk Yıllarında Türk-Rus Ticari ve Ekonomik İlişkileri Üzerine

    OpenAIRE

    KORHAN, Tugba

    2014-01-01

    Birinci Dünya Savası ve ardından imzalanan Sevr Barıs Antlasması’ndan sonra Mustafa Kemal Pasa önderliginde Milli Mücadele baslamıs ardından Genç Türkiye Cumhuriyeti kurulmustur. Yeni Devlet, Osmanlı Devleti’nden borçlu kalan ekonomik mirasın üzerinde, bir taraftan emperyalist güçlere karsı varlıgını devam ettirmeye çalısırken bir taraftan da sanayilesme yoluyla ekonomik kalkınmak için Rusya’dan destek almıs ve böylece iki ülke arasındaki tarihsel iliskililer ve komsuluk bagları dönemde...

  20. Dikkat eksikliği ve hiperaktivite bozukluğu hastalarının zihin kuramı yetilerinin değerlendirilmesi

    OpenAIRE

    ALTINTAŞ, Havva Özge

    2012-01-01

    Amaç: Bu çalışmanın amacı erişkin dikkat eksikliği ve hiperaktivite bozukluğu olgularında zihin kuramı yetilerinin değerlendirilmesi ve zihin kuramı bozukluğu olan, DEHB tanısı almış bireylerde sosyal uyum düzeyinin araştırılmasıdır.Yöntem: Çalışmanın örneklemini Ankara Üniversitesi Tıp Fakültesi Psikiyatri Anabilim Dalı Poliklinikleri'ne başvuran DSM...

    1. GASTRONOMİ TURİZMİ İŞLETMELERİNİN WEB SİTELERİ ÜZERİNE KARŞILAŞTIRMALI BİR DEĞERLENDİRME

      OpenAIRE

      ULUÇAY, Dilek Melike

      2017-01-01

      Kitle turizmine alternatif olarak ortaya çıkmışgastronomi-turizmi, yerel halkın ve destinasyonun bilinirliğini arttırması ileberaber şehir ve ülke imajına büyük katkı sağlaması sebepleri ile yükselenturizm trendleri arasında yerini almıştır. Özellikle turizm gelirlerini arttırmakisteyen ülkelerin bu alanda, tanıtım ve pazarlama faaliyetlerini arttırdıklarıgörülmektedir. Bu noktada yeni iletişim teknolojileri önemli role sahiptir. Özellikleİnternet üzerinden tanıtım ve pazarlama faaliyetleri y...

    2. Empowerment: The Relationship of Women and Power

      Directory of Open Access Journals (Sweden)

      Magdalena León

      2000-01-01

      Full Text Available The use of the term 'empowerment' by feminism is closely linked to the importance that social movements as well as social science theory have attributed to the idea of power. For theorists such as Gramsci, Foucault and Paulo Freire, power is a social relationship that is conditioned historically and socially. Even though they do not refer specifically to the power present in gender relations and do not deploy the word "empowerment”, their analyses inspired reflections on that notion by feminist theorists and activists. Since the emergence of the so-called 'second wave' of feminism, the concept of empowerment has been debated by many women's groups. For women's movements, empowerment is a strategy almed at fostering changes in women's dally lives and fomenting the transformation of social structures.

    3. Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men.

      Science.gov (United States)

      Verschueren, S; Gielen, E; O'Neill, T W; Pye, S R; Adams, J E; Ward, K A; Wu, F C; Szulc, P; Laurent, M; Claessens, F; Vanderschueren, D; Boonen, S

      2013-01-01

      The aim of this study was to determine the relationship between reduced muscle mass (sarcopenia) and areal bone mineral density (BMD(a)) in middle-aged and elderly community-dwelling European men. Men with sarcopenia had significantly lower BMD(a) and were more likely to have osteoporosis compared with men without sarcopenia. In men, the relationship between reduced muscle mass (sarcopenia) and BMD(a) is unclear. This study aimed to determine this relationship in middle-aged and elderly community-dwelling men. Men aged 40-79 years from the Manchester (UK) and Leuven (Belgium) cohorts of the European Male Ageing Study were invited to attend for assessment including dual-energy X-ray absorptiometry, from which appendicular lean mass (aLM), fat mass (FM) and whole-body, spine and hip BMD(a) were determined. Relative appendicular skeletal muscle mass (RASM) was calculated as aLM/height². Muscle strength was assessed in subjects from Leuven. Sarcopenia was defined by RASM at Sarcopenia in Older People (RASM at sarcopenia and osteoporosis. Six hundred seventy-nine men with a mean age of 59.6 (SD = 10.7), contributed data to the analysis; 11.9 % were sarcopenic by the conventional definition. After adjustment for age and centre, aLM, RASM and FM were positively associated with BMD(a). Men with RASM at sarcopenia were more likely to have osteoporosis compared with those with normal RASM (odds ratio = 3.0; 95 % CI = 1.6-5.8). Sarcopenia is associated with low BMD(a) and osteoporosis in middle-aged and elderly men. Further studies are necessary to assess whether maintaining muscle mass contributes to prevent osteoporosis.

    4. Monogenic diabetes syndromes: Locus‐specific databases for Alström, Wolfram, and Thiamine‐responsive megaloblastic anemia

      Science.gov (United States)

      Astuti, Dewi; Sabir, Ataf; Fulton, Piers; Zatyka, Malgorzata; Williams, Denise; Hardy, Carol; Milan, Gabriella; Favaretto, Francesca; Yu‐Wai‐Man, Patrick; Rohayem, Julia; López de Heredia, Miguel; Hershey, Tamara; Tranebjaerg, Lisbeth; Chen, Jian‐Hua; Chaussenot, Annabel; Nunes, Virginia; Marshall, Bess; McAfferty, Susan; Tillmann, Vallo; Maffei, Pietro; Paquis‐Flucklinger, Veronique; Geberhiwot, Tarekign; Mlynarski, Wojciech; Parkinson, Kay; Picard, Virginie; Bueno, Gema Esteban; Dias, Renuka; Arnold, Amy; Richens, Caitlin; Paisey, Richard; Urano, Fumihiko; Semple, Robert; Sinnott, Richard

      2017-01-01

      Abstract We developed a variant database for diabetes syndrome genes, using the Leiden Open Variation Database platform, containing observed phenotypes matched to the genetic variations. We populated it with 628 published disease‐associated variants (December 2016) for: WFS1 (n = 309), CISD2 (n = 3), ALMS1 (n = 268), and SLC19A2 (n = 48) for Wolfram type 1, Wolfram type 2, Alström, and Thiamine‐responsive megaloblastic anemia syndromes, respectively; and included 23 previously unpublished novel germline variants in WFS1 and 17 variants in ALMS1. We then investigated genotype–phenotype relations for the WFS1 gene. The presence of biallelic loss‐of‐function variants predicted Wolfram syndrome defined by insulin‐dependent diabetes and optic atrophy, with a sensitivity of 79% (95% CI 75%–83%) and specificity of 92% (83%–97%). The presence of minor loss‐of‐function variants in WFS1 predicted isolated diabetes, isolated deafness, or isolated congenital cataracts without development of the full syndrome (sensitivity 100% [93%–100%]; specificity 78% [73%–82%]). The ability to provide a prognostic prediction based on genotype will lead to improvements in patient care and counseling. The development of the database as a repository for monogenic diabetes gene variants will allow prognostic predictions for other diabetes syndromes as next‐generation sequencing expands the repertoire of genotypes and phenotypes. The database is publicly available online at https://lovd.euro-wabb.org. PMID:28432734

    5. Removal of natural organic matter and arsenic from water by electrocoagulation/flotation continuous flow reactor

      International Nuclear Information System (INIS)

      Mohora, Emilijan; Rončević, Srdjan; Dalmacija, Božo; Agbaba, Jasmina; Watson, Malcolm; Karlović, Elvira; Dalmacija, Milena

      2012-01-01

      Highlights: ► A continuous electrocoagulation/flotation reactor was designed built and operated. ► Highest NOM removal according to UV 254 was 77% relative to raw groundwater. ► Highest NOM removal accordance to DOC was 71%, relative to raw groundwater. ► Highest As removal archived was 85% (6.2 μg/l), relative to raw groundwater. ► Specific reactor energy and electrode consumption was 1.7 kWh/m 3 and 66 g Al/m 3 . - Abstract: The performance of the laboratory scale electrocoagulation/flotation (ECF) reactor in removing high concentrations of natural organic matter (NOM) and arsenic from groundwater was analyzed in this study. An ECF reactor with bipolar plate aluminum electrodes was operated in the horizontal continuous flow mode. Electrochemical and flow variables were optimized to examine ECF reactor contaminants removal efficiency. The optimum conditions for the process were identified as groundwater initial pH 5, flow rate = 4.3 l/h, inter electrode distance = 2.8 cm, current density = 5.78 mA/cm 2 , A/V ratio = 0.248 cm −1 . The NOM removal according to UV 254 absorbance and dissolved organic matter (DOC) reached highest values of 77% and 71% respectively, relative to the raw groundwater. Arsenic removal was 85% (6.2 μg As/l) relative to raw groundwater, satisfying the drinking water standards. The specific reactor electrical energy consumption was 17.5 kWh/kg Al. The specific aluminum electrode consumption was 66 g Al/m 3 . According to the obtained results, ECF in horizontal continuous flow mode is an energy efficient process to remove NOM and arsenic from groundwater.

    6. The Effects of Applying Betts’ Autonomous Learner Model on Iranian Students

      Directory of Open Access Journals (Sweden)

      Nahid Yarahmadzehi

      2012-09-01

      Full Text Available Classroom-based, teacher-directed language learning has been dominant in language teaching and learning for decades; however, the notion of autonomy is not novel to language teachers. Since the publication of Holec’s book, Autonomy and Foreign Language Learning (1981, autonomy in language learning has been a significant issue for discussion in relation to language learning practices and language teaching principles. Many ESL researchers have turned their attention to learner autonomy in classroom settings; however, learner autonomy in the Iranian context within self-access settings, classroom settings, and school curriculum has not been adequately addressed in the literature. To fill the research gap mentioned above, the present study aims to determine: 1. if Betts’s Autonomous Learner Model (Betts & Kercher, 1999 has any significant effect in terms of students’ self-directed learning readiness, and 2. if Betts’s Autonomous Learner Model has any significant effect on students’ English language proficiency. Adopting a quasi-experimental design, the study involved a comparison between the experimental and the control group. Two instruments were used: Gugliemino’s (1977 Self-Directed Learning Readiness Scale (SDLRS; and standardized TOEFL test. 30 students (group A were taught English based on a pedagogical model, which blended Betts’s ALM with classroom instruction and 30 students (group B were taught through a traditional teacher-directed method. Finally, after six months of treatment, TOEFL test and SDLRS test were administered as the post-test and the results were analyzed by means of SPSS software. The results showed that ALM can work with Iranian students as evidenced by generally average performance on SDLRS and TOEFL post-tests.

    7. BRAF, KIT, NRAS, GNAQ and GNA11 mutation analysis in cutaneous melanomas in Turkish population

      Directory of Open Access Journals (Sweden)

      Ismail Yilmaz

      2015-01-01

      Full Text Available Background: KIT and mitogen-activated protein kinase cascade are important for melanomagenesis. In the present study, we analyzed the frequency of BRAF, NRAS, KIT, GNAQ and GNA11 gene mutations and investigated their association with clinicopathological features of melanomas in Turkish population. Materials and Methods: Forty-seven primary cutaneous melanomas were included in our study. Sanger sequencing method was used for mutation analysis in all cases. Results: Mean age was 62.1 (29-101 years. Female:male ratio was 17:30. Among 47 melanomas, 14 (29.8% BRAF, 10 (21.3% NRAS, 4 (8.5% KIT and 1(2.1% GNAQ gene mutations were detected. Two of the KIT mutations were found in acral lentiginous melanoma (ALM. In the head and neck region, mutation frequency was significantly lower than in other locations (P = 0.035. The only GNAQ gene mutation (p.Q209L was detected in a melanoma arising from blue nevus located on the scalp. None of the melanomas harbored NRAS exon 2, KIT exon 13/17/18, GNAQ exon 4 and GNA11 exon 4/5 mutations. Overall mutation frequency did not show significant difference between metastatic (8/14, 57.1% and nonmetastatic (18/33, 54.5% patients. We did not observe any significant association between mutation status and gender or age of various patients. Conclusions: Our results support that BRAF and NRAS gene mutations are common in cutaneous melanomas. The activating mutations of KIT gene are rare and especially seen in ALM. GNAQ and GNA11 mutations are infrequent in cutaneous melanomas and may be associated only with melanomas arising from blue nevus.

    8. Influence of landscape heterogeneity on water available to tropical forests in an Amazonian catchment and implications for modeling drought response: Water Available to Tropical Forest

      Energy Technology Data Exchange (ETDEWEB)

      Fang, Yilin; Leung, Lai-Yung; Duan, Zhuoran; Wigmosta, Mark S.; Maxwell, Reed M.; Chambers, Jeffrey Q.; Tomasella, Javier

      2017-08-18

      The Amazon basin experienced periodic droughts in the past, and climate models projected more intense and frequent droughts in the future. How tropical forests respond to drought may depend on water availability, which is modulated by landscape heterogeneity. Using the one-dimensional ACME Land Model (ALM) and the three-dimensional ParFlow variably saturated flow model, a series of numerical experiments were performed for the Asu catchment in central Amazon to elucidate processes that influence water available for plant use and provide insights for improving Earth system models. Results from ParFlow show that topography has a dominant influence on groundwater table and runoff through lateral flow. Without any representations of lateral processes, ALM simulates very different seasonal variations in groundwater table and runoff compared to ParFlow even if it is able to reproduce the long-term spatial average groundwater table of ParFlow through simple parameter calibration. In the ParFlow simulations, the groundwater table is evidently deeper and the soil saturation is lower in the plateau compared to the valley. However, even in the plateau during the dry season in the drought year of 2005, plant transpiration is not water stressed in the ParFlow simulations as the soil saturation is still sufficient to maintain a soil matric potential for the stomata to be fully open. This finding is insensitive to uncertainty in atmospheric forcing and soil parameters, but the empirical wilting formulation used in the models is an important factor that should be addressed using observations and modeling of coupled plant hydraulics-soil hydrology processes in future studies.

    9. Improving the Effectiveness of Penicillin Allergy De-labeling.

      Science.gov (United States)

      Bourke, Jack; Pavlos, Rebecca; James, Ian; Phillips, Elizabeth

      2015-01-01

      Approximately 10-20% of hospitalized patients are labeled as penicillin allergic, and this is associated with significant health and economic costs. We looked at the effectiveness of penicillin allergy de-labeling in clinical practice with the aim of deriving risk stratification models to guide testing strategies. Consecutive patients aged 15 years or more, referred to a Western Australian public hospital drug allergy service between 2008 and 2013 for beta-lactam allergy, were included. Follow-up surveys were conducted. Results of skin prick testing and intradermal testing (SPT/IDT) and oral challenge (OC), and follow-up of post testing antibiotic usage were the main outcomes. SPT/IDT was performed in 401 consecutive patients with immediate (IMM) (≤ 1 hour) (n = 151) and nonimmediate (NIM) (>1 hour) (n = 250) reactions. Of 341 patients, 42 (12.3%) were SPT/IDT+ to ≥ 1 penicillin reagents, including 35/114 (30.4%) in the IMM group and 7/227 (3.1%) in the NIM group (P penicillin VK (SPT/IDT negative predictive value [NPV] 99.2%). Selective or unrestricted beta-lactam was recommended in almost 90% overall, including 238/250 (95.2%) in the NIM group and 126/151 (83.4%) in the IMM group (P = .0001). Of 182 patients, 137 (75.3%) were following the allergy label modifications (ALM) at the time of follow-up. Penicillin SPT/IDT/OC safely de-labels penicillin-allergic patients and identifies selective beta-lactam allergies; however, incomplete adherence to ALM recommendations impairs effectiveness. Infrequent SPT/IDT+ and absent OC reactions in patients with NIM reactions suggest OC alone to be a safe and cost-effective de-labeling strategy that could improve the coverage of penicillin allergy de-labeling in lower risk populations. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

    10. Verification of resistance to three mediated microbial strains and cancerous defense against MCF7 compared to HepG2 through microwave synthesized plant-mediated silver nanoparticle

      Science.gov (United States)

      Abdel-Fattah, W. I.; Eid, M. M.; Hanafy, M. F.; Hussein, M.; Abd El-Moez, Sh I.; El-Hallouty, S. M.; Mohamed, E.

      2015-09-01

      The antimicrobial and anticancer efficiencies of green synthesized silver nanoparticles (AgNPs) through biogenic extracts were assessed on three bacterial strains and two cancer cell lines. Bio-synthesized AgNPs were achieved through domestic microwave generator for obtaining extracts from Asian nuts and Egyptian blackberry fruits. Surface plasmon resonance (SPR) ˜435 nm demonstrated AgNPs earlier formation by the fruit extract. Capping by triglycerides/almond and phenols/berry extracts were responsible for the reduction proved by FTIR. XRD calculated particle sizes were 18 and 42 nm while TEM sizes are 24.5 and 21.5 nm for AgNPs from almond nut and blackberry fruits extracts (Alm.N.Ext. and BB.F.Ext.), respectively. Ag 3d5/2 was recorded at 368.12 eV for both samples through XPS. The monodispersed AgNPs recorded 0.727 and 0.5 polydispersity indices (PdI) for almond/Ag and berry/Ag, respectively. Zeta potential ˜ -31 and -13.2 for the same sequence confirmed the higher stability of the former. Reaction kinetics confirmed the advantage of fruit extract consuming only six minutes compared to nuts, consuming twice. Bactericidal effect of the extracts seldomly presented remarkable inhibition compared to extracts/Ag against the three species. In addition, Alm.N.Ext. showed the highest inhibition against staphylococcus aureus (S. aureus) at 4 mM. The anti-cancerous effect of Ag/berry against HepG2 is stronger than Ag/almond, and similarly for MCF7.

    11. On charged particle equilibrium violation in external photon fields

      International Nuclear Information System (INIS)

      Bouchard, Hugo; Seuntjens, Jan; Palmans, Hugo

      2012-01-01

      Purpose: In a recent paper by Bouchard et al.[Med. Phys. 36(10), 4654-4663 (2009)], a theoretical model of quality correction factors for idealistic so-called plan-class specific reference (PCSR) fields was proposed. The reasoning was founded on the definition of PCSR fields made earlier by Alfonso et al.[Med. Phys. 35(11), 5179-5186 (2008)], requiring the beam to achieve charged particle equilibrium (CPE), in a time-averaged sense, in the reference medium. The relation obtained by Bouchard et al. was derived using Fano's theorem (1954) which states that if CPE is established in a given medium, the dose is independent of point-to-point density variations. A potential misconception on the achievability of the condition required by Fano (1954) might be responsible for false practical conclusions, both in the definition of PCSR fields as well as the theoretical model of quality correction factor. Methods: In this paper, the practical achievability of CPE in external beams is treated in detail. The fact that this condition is not achievable in single or composite deliveries is illustrated by an intuitive method and is also formally demonstrated. Conclusions: Fano's theorem is not applicable in external beam radiation dosimetry without (virtually) removing attenuation effects, and therefore, the relation conditionally defined by Bouchard et al. (2009) cannot be valid in practice. A definition of PCSR fields in the recent formalism for nonstandard beams proposed by Alfonso et al. (2008) should be modified, revising the criterion of CPE condition. The authors propose reconsidering the terminology used to describe standard and nonstandard beams. The authors argue that quality correction factors of intensity modulated radiation therapy PCSR fields (i.e., k Q pcsr ,Q f pcsr ,f ref ) could be unity under ideal conditions, but it is concluded that further investigation is necessary to confirm that hypothesis.

    12. Verification of resistance to three mediated microbial strains and cancerous defense against MCF7 compared to HepG2 through microwave synthesized plant-mediated silver nanoparticle

      International Nuclear Information System (INIS)

      Abdel-Fattah, W I; Eid, M M; Hanafy, M F; Hussein, M; Mohamed, E; Abd El-Moez, Sh I; El-Hallouty, S M

      2015-01-01

      The antimicrobial and anticancer efficiencies of green synthesized silver nanoparticles (AgNPs) through biogenic extracts were assessed on three bacterial strains and two cancer cell lines. Bio-synthesized AgNPs were achieved through domestic microwave generator for obtaining extracts from Asian nuts and Egyptian blackberry fruits. Surface plasmon resonance (SPR) ∼435 nm demonstrated AgNPs earlier formation by the fruit extract. Capping by triglycerides/almond and phenols/berry extracts were responsible for the reduction proved by FTIR. XRD calculated particle sizes were 18 and 42 nm while TEM sizes are 24.5 and 21.5 nm for AgNPs from almond nut and blackberry fruits extracts (Alm.N.Ext. and BB.F.Ext.), respectively. Ag 3d5/2 was recorded at 368.12 eV for both samples through XPS. The monodispersed AgNPs recorded 0.727 and 0.5 polydispersity indices (PdI) for almond/Ag and berry/Ag, respectively. Zeta potential ∼ −31 and −13.2 for the same sequence confirmed the higher stability of the former. Reaction kinetics confirmed the advantage of fruit extract consuming only six minutes compared to nuts, consuming twice. Bactericidal effect of the extracts seldomly presented remarkable inhibition compared to extracts/Ag against the three species. In addition, Alm.N.Ext. showed the highest inhibition against staphylococcus aureus (S. aureus) at 4 mM. The anti-cancerous effect of Ag/berry against HepG2 is stronger than Ag/almond, and similarly for MCF7. (paper)

    13. Monogenic diabetes syndromes: Locus-specific databases for Alström, Wolfram, and Thiamine-responsive megaloblastic anemia.

      Science.gov (United States)

      Astuti, Dewi; Sabir, Ataf; Fulton, Piers; Zatyka, Malgorzata; Williams, Denise; Hardy, Carol; Milan, Gabriella; Favaretto, Francesca; Yu-Wai-Man, Patrick; Rohayem, Julia; López de Heredia, Miguel; Hershey, Tamara; Tranebjaerg, Lisbeth; Chen, Jian-Hua; Chaussenot, Annabel; Nunes, Virginia; Marshall, Bess; McAfferty, Susan; Tillmann, Vallo; Maffei, Pietro; Paquis-Flucklinger, Veronique; Geberhiwot, Tarekign; Mlynarski, Wojciech; Parkinson, Kay; Picard, Virginie; Bueno, Gema Esteban; Dias, Renuka; Arnold, Amy; Richens, Caitlin; Paisey, Richard; Urano, Fumihiko; Semple, Robert; Sinnott, Richard; Barrett, Timothy G

      2017-07-01

      We developed a variant database for diabetes syndrome genes, using the Leiden Open Variation Database platform, containing observed phenotypes matched to the genetic variations. We populated it with 628 published disease-associated variants (December 2016) for: WFS1 (n = 309), CISD2 (n = 3), ALMS1 (n = 268), and SLC19A2 (n = 48) for Wolfram type 1, Wolfram type 2, Alström, and Thiamine-responsive megaloblastic anemia syndromes, respectively; and included 23 previously unpublished novel germline variants in WFS1 and 17 variants in ALMS1. We then investigated genotype-phenotype relations for the WFS1 gene. The presence of biallelic loss-of-function variants predicted Wolfram syndrome defined by insulin-dependent diabetes and optic atrophy, with a sensitivity of 79% (95% CI 75%-83%) and specificity of 92% (83%-97%). The presence of minor loss-of-function variants in WFS1 predicted isolated diabetes, isolated deafness, or isolated congenital cataracts without development of the full syndrome (sensitivity 100% [93%-100%]; specificity 78% [73%-82%]). The ability to provide a prognostic prediction based on genotype will lead to improvements in patient care and counseling. The development of the database as a repository for monogenic diabetes gene variants will allow prognostic predictions for other diabetes syndromes as next-generation sequencing expands the repertoire of genotypes and phenotypes. The database is publicly available online at https://lovd.euro-wabb.org. © 2017 The Authors. **Human Mutation published by Wiley Periodicals, Inc.

    14. An integrated quality by design and mixture-process variable approach in the development of a capillary electrophoresis method for the analysis of almotriptan and its impurities.

      Science.gov (United States)

      Orlandini, S; Pasquini, B; Stocchero, M; Pinzauti, S; Furlanetto, S

      2014-04-25

      The development of a capillary electrophoresis (CE) method for the assay of almotriptan (ALM) and its main impurities using an integrated Quality by Design and mixture-process variable (MPV) approach is described. A scouting phase was initially carried out by evaluating different CE operative modes, including the addition of pseudostationary phases and additives to the background electrolyte, in order to approach the analytical target profile. This step made it possible to select normal polarity microemulsion electrokinetic chromatography (MEEKC) as operative mode, which allowed a good selectivity to be achieved in a low analysis time. On the basis of a general Ishikawa diagram for MEEKC methods, a screening asymmetric matrix was applied in order to screen the effects of the process variables (PVs) voltage, temperature, buffer concentration and buffer pH, on critical quality attributes (CQAs), represented by critical separation values and analysis time. A response surface study was then carried out considering all the critical process parameters, including both the PVs and the mixture components (MCs) of the microemulsion (borate buffer, n-heptane as oil, sodium dodecyl sulphate/n-butanol as surfactant/cosurfactant). The values of PVs and MCs were simultaneously changed in a MPV study, making it possible to find significant interaction effects. The design space (DS) was defined as the multidimensional combination of PVs and MCs where the probability for the different considered CQAs to be acceptable was higher than a quality level π=90%. DS was identified by risk of failure maps, which were drawn on the basis of Monte-Carlo simulations, and verification points spanning the design space were tested. Robustness testing of the method, performed by a D-optimal design, and system suitability criteria allowed a control strategy to be designed. The optimized method was validated following ICH Guideline Q2(R1) and was applied to a real sample of ALM coated tablets

    15. Body composition in long-term survivors of acute lymphoblastic leukemia diagnosed in childhood and adolescence: A focus on sarcopenic obesity.

      Science.gov (United States)

      Marriott, Christopher J C; Beaumont, Lesley F; Farncombe, Troy H; Cranston, Amy N; Athale, Uma H; Yakemchuk, Valerie N; Webber, Colin E; Barr, Ronald D

      2018-03-15

      The late effects of treatment for acute lymphoblastic leukemia (ALL) include disordered body composition, especially obesity. Less attention has been focused on the loss of skeletal muscle mass (SMM) and the combined morbidity of sarcopenic obesity. A cross-sectional study of body composition was undertaken via dual-energy x-ray absorptiometry in 75 long-term survivors of ALL (more than 10 years after the diagnosis). Measures were obtained of the fat mass (FM), fat-free mass (equivalent to the lean body mass [LBM]), and whole-body bone mineral content. Health-related quality of life (HRQL) was measured with the Health Utilities Index. The sum of the FM, LBM, and whole-body bone mineral content matched the total body weight measured directly (r = 0.998). The appendicular lean mass (ALM) was derived from the LBM in all 4 limbs and accounted for approximately 75% of the SMM. According to the fat mass index (FMI; ie, FM/height 2 ), 12% of females and 18% of males were frankly obese by World Health Organization criteria. The median FMI z score was + 0.40, whereas the median z score for the appendicular lean mass index (ALMI; ie, ALM/height 2 ) was -0.40. Sarcopenic obesity, defined as a positive FMI z score with a negative ALMI z score, was present in 32 subjects (43%). There were statistically significant and clinically important differences in overall HRQL between subjects with and without sarcopenic obesity. Sarcopenic obesity is prevalent in long-term survivors of ALL, and this places them in double jeopardy from excess body fat and inadequate SMM (eg, a combination of metabolic and frailty syndromes). It is associated with an adverse impact on overall HRQL. Cancer 2018;124:1225-31. © 2017 American Cancer Society. © 2017 American Cancer Society.

    16. Age- and gender-dependent values of skeletal muscle mass in healthy children and adolescents.

      Science.gov (United States)

      Webber, Colin E; Barr, Ronald D

      2012-03-01

      Skeletal muscle mass (SMM) can be extracted from whole-body scans obtained by X-ray-based dual-photon absorptiometry (DXA). There is a need to establish expected age-dependent values for children and adolescents. Appendicular lean tissue mass (ALM) was extracted from whole-body DXA scans in 140 healthy children and adolescents (68 females and 72 males). Whole-body SMM was calculated from ALM using equations developed by Kim et al. (Am J Clin Nutr 84:1014-1020, 2006). Age-dependent patterns of increase in SMM were derived by fitting SMM values to equations that consisted of the sum of two logistic expressions, one accounting for SMM changes during growth and the other for SMM changes during puberty. Normal ranges were defined so that 95% of the SMM values were included. The reproducibility of SMM measurements was obtained from whole-body DXA scans repeated on three occasions in each of a separate group of 32 normal children with repositioning between scans. Normal ranges are presented as equations describing the age-dependent pattern of increase in SMM as well as population standard deviations that increased steadily with age. For 15 children below age 10, SMM reproducibility (95% CI) was 149 g (119-199 g) while for 17 children and adolescents over age 10, reproducibility was 170 g (138-223 g). DXA-based measurements of SMM in children and adolescents are reproducible and can be expressed in terms of age-dependent Z scores.

    17. Role of nanostructured gold surfaces on monocyte activation and Staphylococcus epidermidis biofilm formation

      Directory of Open Access Journals (Sweden)

      Svensson S

      2014-02-01

      Full Text Available Sara Svensson,1,2 Magnus Forsberg,1,2 Mats Hulander,1,2 Forugh Vazirisani,1,2 Anders Palmquist,1,2 Jukka Lausmaa,2,3 Peter Thomsen,1,2 Margarita Trobos1,21Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; 2BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden; 3SP Technical Research Institute of Sweden, Borås, SwedenAbstract: The role of material surface properties in the direct interaction with bacteria and the indirect route via host defense cells is not fully understood. Recently, it was suggested that nanostructured implant surfaces possess antimicrobial properties. In the current study, the adhesion and biofilm formation of Staphylococcus epidermidis and human monocyte adhesion and activation were studied separately and in coculture in different in vitro models using smooth gold and well-defined nanostructured gold surfaces. Two polystyrene surfaces were used as controls in the monocyte experiments. Fluorescent viability staining demonstrated a reduction in the viability of S. epidermidis close to the nanostructured gold surface, whereas the smooth gold correlated with more live biofilm. The results were supported by scanning electron microscopy observations, showing higher biofilm tower formations and more mature biofilms on smooth gold compared with nanostructured gold. Unstimulated monocytes on the different substrates demonstrated low activation, reduced gene expression of pro- and anti-inflammatory cytokines, and low cytokine secretion. In contrast, stimulation with opsonized zymosan or opsonized live S. epidermidis for 1 hour significantly increased the production of reactive oxygen species, the gene expression of tumor necrosis factor-α (TNF-α, interleukin-1β (IL-1β, IL-6, and IL-10, as well as the secretion of TNF-α, demonstrating the ability of the cells to elicit a response and actively phagocytose prey. In addition, cells cultured on the smooth

    18. Forestry entrepreneurs' environmental know-how

      International Nuclear Information System (INIS)

      Hyytiaeinen, J.

      1998-01-01

      The TTS-Institute's Department of Forestry looked into the subject of environmental know-how of forestry entrepreneurs by means of a questionnaire study conducted in Etelae-Karjala, south-eastern Finland. This study is part of a pilot project called (SME Entrepreneurs' Environmental Know-How in the Forestry Sector: Development and Training) financed by the European Social Fund. The implementation of the project is the shared responsibility of Tmi JukkaNet, TTS-Institute and the Finnish Association of Machine Con- tractors. The TTS-Institute's Department of Forestry mailed questionnaire forms to 138 entrepreneurs at the beginning of the year. The objective was to obtain information on the companies' planning of their future, operating culture, quality of operations, learning, their knowledge of the environmental guidelines, and general attitude concerning matters connected to the environment. The response percentage was 50 %. The responses were divided as follows: forestry contracting 22 (32 %), agricultural practitioners 30 (43 %), and others 17 (25 %). Most of all, the entrepreneurs were found to turn to trade journals as sources of information. Environmental training had been obtained by every third person during the previous year. Sixty four percent of all the respondents had not taken part in any environmental training during the previous year. Of those engaged in forestry contracting, 71 % had been exposed to training; the corresponding figure for agricultural entrepreneurs was 27 %. Entrepreneurs co-operate in environmental matters most of all with their customers and landowners. Co-operation with the environmental organisations was most inadequate. Agricultural entrepreneurs cooperated with environmental authorities more than their colleagues engaged in forestry contracting. Quality systems connected to care of the environment were rare. Only two contractors, two practitioners of farm forestry and one value-added converter of wood had a quality system

    19. Mineral chemistry of garnet in pegmatite and metamorphic rocks in the Hamedan area

      Directory of Open Access Journals (Sweden)

      Ahmad Ahmadi Khalaji

      2015-10-01

      -existing tourmaline with pegmatite garnets and andalusite with schist garnets; zoning in garnets (oscillatory zoning of Al in pegmatite garnet, Mn increasing in the cores of schist garnet contrasted with Mn decreasing in the cores of pegmatite garnets; the decrease of Mg in the cores of pegmatite garnets, contrasted with the increase of this element in the cores of schist garnets; and the linear trends of Al and Ca in hornfels garnets Pyrope garnet composition in schist indicates a closed system for garnet formation condition in schist and a magmatic source for pegmatites. The compositions of garnets from schists change from Alm0.63, Prp0.07, Sps0.24, Grs0.05 in the cores, to Alm0.71, Prp0.09, Sps0.13, Grs0.05 in the rims. Garnets from pegmatites show a change from Alm0.73, Prp0.015, Sps0.24, Grs0.07 in the cores, to Alm0.71, Prp0.011, Sps0.28, Grs0.00 in the rims. Garnets from hornfelses showed changes from Alm 0.79, Prp0.14, Sps 0.06, Grs0.07 in the cores to Alm 0.8, Prp0.13, Sps 0.05, Grs0.01 in the rims. Discussion The percent of almandine and spessartine in the garnets of the schists and pegmatites are higher than that of garnets in the hornfelses. Almandine and spessartine in the pegmatite garnets from core to rim show a completely reversed trend. In the schist garnets from core to rim, the almandine trend is decreasing outward– increasing inward, while the spessartine trend is increasing – decreasing. In the hornfels garnets no specific trend could be determined, there is no zoning. This difference in trend between pegmatite garnets from that in schist garnets and hornfels garnets shows differences in their origin. Texture homogenization, rich in potassium, metaluminous to peraluminous magma of Hamedan granitoid intrusion (Aliani et al., 2012, Peraluminous biotite in this intrusion and lack of garnet zoning show that garnet pegmatites have been formed directly from granitic melt crystallization. References Aliani, F., Maanijou, M., Sabouri, Z. and Sepahi, A.A., 2012

    20. Propriedades mecânicas do músculo gastrocnêmio de ratas, imobilizado e posteriormente submetido a diferentes protocolos de alongamento Mechanical properties of gastrocnemius muscle of female rats immobilized and posteriorly submitted to different stretching protocols

      Directory of Open Access Journals (Sweden)

      Juliana Cristina Polizello

      2009-06-01

      Full Text Available O alongamento é amplamente utilizado na prática clínica da fisioterapia e no desporto, porém, as alterações mecânicas que essa técnica gera no músculo esquelético são pouco exploradas cientificamente. Este estudo avaliou as alterações mecânicas que acometem o músculo gastrocnêmio de ratas Wistar, adultas jovens, após 14 dias de imobilização e, secundariamente, submetido a alongamento manual passivo por 10 dias consecutivos, aplicado uma ou duas vezes ao dia. Foram utilizados 50 animais, sendo 10 para cada grupo: Controle (GC; Imobilizado (GI; Imobilizado e Liberado (GIL; Imobilizado e alongado uma vez ao dia (GIA1; e Imobilizado e alongado duas vezes ao dia (GIA2. O músculo gastrocnêmio foi submetido ao ensaio mecânico de tração, onde foram avaliadas as propriedades de carga e alongamento nos limites máximo e proporcional, além de rigidez e resiliência. A imobilização reduziu os valores das propriedades mecânicas de carga no limite máximo (CLM, carga no limite proporcional (CLP, alongamento no limite máximo (ALM, rigidez e resiliência, em 44,4%, 34,4%, 27,6%, 64,4% e 54%, respectivamente, quando comparados com os valores do GC. A remobilização livre e o alongamento restauraram as propriedades de CLM, CLP, ALM, rigidez e resiliência do músculo, exceto para o GIA2, que foi incapaz de restabelecer a propriedade de ALM (31,3% menor que GC. Concluí-se, portanto que, após 14 dias de imobilização segmentar, cargas individuais de alongamento e a livre movimentação permitem restituir as propriedades mecânicas do tecido muscular.Stretching is widely employed in physiotherapeutic clinical practice and in sportive activities; however, the mechanical alterations of the skeletal muscle generated by this technique are poorly scientifically investigated. This study evaluated the mechanical alterations suffered by the gastrocnemius muscle of young adult female Wistar rats, submitted to14 days of immobilization followed

    1. Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project.

      Science.gov (United States)

      Scott, David; Cumming, Robert; Naganathan, Vasi; Blyth, Fiona; Le Couteur, David G; Handelsman, David J; Seibel, Markus; Waite, Louise M; Hirani, Vasant

      2018-04-09

      Previous cross-sectional studies investigating associations of sarcopenic obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine associations of sarcopenic obesity with MetS and insulin resistance over five years in community-dwelling older men. 1231 men aged ≥70 years had appendicular lean mass (ALM) and body fat percentage assessed by dual-energy X-ray absorptiometry and hand grip strength and gait speed tests. Sarcopenia was defined as low ALM/height (m 2 ) and low hand grip strength or gait speed (European Working Group definition); obesity was defined as body fat percentage ≥30%. MetS was assessed at baseline and 5-years later. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was assessed at 5-years only. Men with sarcopenic obesity (odds ratio, 95% CI: 2.07, 1.21-3.55) and non-sarcopenic obesity (4.19, 3.16-5.57) had higher MetS likelihood than those with non-sarcopenic non-obesity at baseline. Higher gait speed predicted lower odds for prevalent MetS (0.45, 0.21-0.96 per m/s). Higher body fat predicted increased odds for prevalent and incident MetS (1.14, 1.11-1.17 and 1.11, 1.02-1.20 per kg, respectively) and deleterious 5-year changes in MetS fasting glucose, high-density lipoprotein cholesterol and triglycerides (all P < 0.05). Compared with non-sarcopenic non-obesity, estimated marginal means for HOMA-IR at 5-years were higher in non-sarcopenic obesity only (1.0, 0.8-1.1 vs 1.3, 1.2-1.5; P < 0.001). Similar results were observed when sarcopenic obesity was defined by waist circumference. Sarcopenic obesity does not appear to confer greater risk for incident MetS or insulin resistance than obesity alone in community-dwelling older men. Copyright © 2018 Elsevier Inc. All rights reserved.

    2. Computational study of fluid flow and heat transfer in composite packed beds of spheres with low tube to particle diameter ratio

      International Nuclear Information System (INIS)

      Yang, Jian; Wu, Jiangquan; Zhou, Lang; Wang, Qiuwang

      2016-01-01

      Highlights: • Flow and heat transfer in composite packed beds with low d_t/d_p_e are investigated. • The wall effect would be restrained with radially layered composite packing (RLM). • Heat flux and overall heat transfer efficiency can be improved with RLM packing. - Abstract: The effect of the tube wall on the fluid flow and heat transfer would be important in the packed bed with low tube to particle diameter ratio, which may lead to flow and temperature maldistributions inside, and the heat transfer performance may be lowered. In the present paper, the flow and heat transfer performances in both the composite and uniform packed beds of spheres with low tube to particle diameter were numerically investigated, where the composite packing means randomly packing with non-uniform spheres and the uniform packing means randomly packing with uniform spheres, including radially layered composite packing (RLM), axially layered composite packing (ALM), randomly composite packing (RCM) and randomly uniform packing (RPM). Both the composite and uniform packings were generated with discrete element method (DEM), and the influence of the wall effect on the flow and heat transfer in the packed beds were carefully studied and compared with each other. Firstly, it is found that, the wall effect on the velocity and temperature distributions in the randomly packed bed of uniform spheres (RPM) with low tube to particle diameter ratio were obvious. The average velocity of the near-tube-wall region is higher than that of the inner-tube region in the bed. When the tube wall is adiabatic, the average temperature of the near-tube-wall region is lower. With radially layered composite packing method (RLM), smaller pores would be formed close to the tube wall and big flow channels would be formed in the inner-tube region of the bed, which would be benefit to restrain the wall effect and improve heat transfer in the bed with low tube to particle diameter ratio. Furthermore, it is also

    3. A Large-Eddy Simulation Study of Vertical Axis Wind Turbine Wakes in the Atmospheric Boundary Layer

      Science.gov (United States)

      Shamsoddin, Sina; Porté-Agel, Fernando

      2017-04-01

      In a future sustainable energy vision, in which diversified conversion of renewable energies is essential, vertical axis wind turbines (VAWTs) exhibit some potential as a reliable means of wind energy extraction alongside conventional horizontal axis wind turbines (HAWTs). Nevertheless, there is currently a relative shortage of scientific, academic and technical investigations of VAWTs as compared to HAWTs. Having this in mind, in this work, we aim to, for the first time, study the wake of a single VAWT placed in the atmospheric boundary layer using large-eddy simulation (LES). To do this, we use a previously-validated LES framework in which an actuator line model (ALM) is incorporated. First, for a typical three- and straight-bladed 1-MW VAWT design, the variation of the power coefficient with both the chord length of the blades and the tip-speed ratio is analyzed by performing 117 simulations using LES-ALM. The optimum combination of solidity (defined as Nc/R, where N is the number of blades, c is the chord length and R is the rotor radius) and tip-speed ratio is found to be 0.18 and 4.5, respectively. Subsequently, the wake of a VAWT with these optimum specifications is thoroughly examined by showing different relevant mean and turbulence wake flow statistics. It is found that for this case, the maximum velocity deficit at the equator height of the turbine occurs 2.7 rotor diameters downstream of the center of the turbine, and only after that point, the wake starts to recover. Moreover, it is observed that the maximum turbulence intensity (TI) at the equator height of the turbine occurs at a distance of about 3.8 rotor diameters downstream of the turbine. As we move towards the upper and lower edges of the turbine, the maximum TI (at a certain height) increases, and its location moves relatively closer to the turbine. Furthermore, whereas both TI and turbulent momentum flux fields show clear vertical asymmetries (with larger magnitudes at the upper wake edge

    4. A Large-Eddy Simulation Study of Vertical Axis Wind Turbine Wakes in the Atmospheric Boundary Layer

      Directory of Open Access Journals (Sweden)

      Sina Shamsoddin

      2016-05-01

      Full Text Available In a future sustainable energy vision, in which diversified conversion of renewable energies is essential, vertical axis wind turbines (VAWTs exhibit some potential as a reliable means of wind energy extraction alongside conventional horizontal axis wind turbines (HAWTs. Nevertheless, there is currently a relative shortage of scientific, academic and technical investigations of VAWTs as compared to HAWTs. Having this in mind, in this work, we aim to, for the first time, study the wake of a single VAWT placed in the atmospheric boundary layer using large-eddy simulation (LES. To do this, we use a previously-validated LES framework in which an actuator line model (ALM is incorporated. First, for a typical three- and straight-bladed 1-MW VAWT design, the variation of the power coefficient with both the chord length of the blades and the tip-speed ratio is analyzed by performing 117 simulations using LES-ALM. The optimum combination of solidity (defined as N c / R , where N is the number of blades, c is the chord length and R is the rotor radius and tip-speed ratio is found to be 0.18 and 4.5, respectively. Subsequently, the wake of a VAWT with these optimum specifications is thoroughly examined by showing different relevant mean and turbulence wake flow statistics. It is found that for this case, the maximum velocity deficit at the equator height of the turbine occurs 2.7 rotor diameters downstream of the center of the turbine, and only after that point, the wake starts to recover. Moreover, it is observed that the maximum turbulence intensity (TI at the equator height of the turbine occurs at a distance of about 3.8 rotor diameters downstream of the turbine. As we move towards the upper and lower edges of the turbine, the maximum TI (at a certain height increases, and its location moves relatively closer to the turbine. Furthermore, whereas both TI and turbulent momentum flux fields show clear vertical asymmetries (with larger magnitudes at the

    5. Selectividad de pecoreo de la abeja sin aguijón Melipona beecheii Bennett en la EEPF "Indio Hatuey", Matanzas Foraging selectivity of the stingless bee Melipona beecheii Bennett at the EEPF "Indio Hatuey", Matanzas

      Directory of Open Access Journals (Sweden)

      Leydi Fonte

      2012-09-01

      Full Text Available El trabajo se realizó en la EEPF "Indio Hatuey", con el objetivo de determinar la selectividad de pecoreo de la abeja sin aguijón (Melipona beecheii Bennett, mediante el análisis palinológico de muestras de miel y polen. Previamente se realizó un inventario florístico del área, alrededor del emplazamiento del meliponario, basado en el radio de vuelo de las abejas. En las silvopasturas se utilizó el método de la escalera, y en el caso de los cercados vivos se contaron los árboles cada 10 m y se reflejaron en el croquis del área muestreada. En las arboledas y los traspatios de las viviendas se contaron y clasificaron todos los árboles existentes, y en el estrato herbáceo se aplicó el método de los pasos. En ambos tipos de muestra predominaron los granos de polen de guayaba (Psidium guajava y almácigo (Bursera simaruba, seguidos por los de dormidera (Mimosa pudica, sensitiva (Mimosa pigra, y naranjo y limonero (Citrus spp.. Se concluye que las abejas meliponas presentaron una marcada selectividad de pecoreo por las floraciones del almácigo y la guayaba, y que la Estación cuenta con el potencial melífero suficiente para que puedan desarrollarse favorablemente, sobre una base alimentaria sustentable.The work was conducted at the EEPF "Indio Hatuey" to determine the foraging selectivity of stingless bees (Melipona beecheii Bennett through the analysis of honey and pollen samples. A floristic inventory of the area had been previously made around the apiary location, taking into consideration the bees' flight radius. The stair method was used in the silvopastures, and in the case of the living fences the trees were counted every 10 meters and this was shown in the sketch of the sampled area. In the groves and yards all trees where counted and classified, and in the herbaceous stratum the step method was applied. The pollen grains of guava (Psidium guajava and mastic tree (Bursera simaruba predominated in both kinds of samples

    6. DENSIDAD CRÍTICA DE Meloidogyne exigua EN PLANTAS DE ALMÁCIGO DE CAFÉ VARIEDAD CATURRA

      Directory of Open Access Journals (Sweden)

      Mainor Rojas

      2013-01-01

      Full Text Available El objetivo del estudio fue evaluar el efecto de densidad creciente de Meloidogyne exigua sobre el desarrollo de plantas de almácigo. Se trasplantaron plántulas de café variedad caturra a bolsas de polietileno con 1335 cm3 de sustrato desinfectado, para establecer un ensayo con diseño de bloques completos al azar, con 8 repeticiones. Los tratamientos aplicados consistieron de poblaciones iniciales (Pi de 0; 0,125; 0,25; 0,5; 1; 2; 4; 8; 16; 32 y 64 huevos+J2/ cm3 de sustrato, aplicadas un mes después del trasplante. El modelo y=m+(1-m ZP-T aplicado 234 días después del trasplante para la altura, diámetro, número de nudos y peso fresco aéreo, indicó que el límite de tolerancia (T fue de 0,66; 0,06; 0,13 y 0,88 huevos+J2/cm3, respectivamente; la producción mínima relativa (m fue de 0,79; 0,79; 0,33 y 0,54 respectivamente, a Pi iguales o mayores a 64 huevos+J2/cm3. El índice de agallas alcanzó el máximo a partir de una Pi de 2; el pico máximo de nematodos en el suelo y las raíces se alcanzó con Pi entre 2 y 4; mientras la tasa máxima de reproducción fue de 114 con Pi de 0,125. Se concluyó que la densidad crítica fue cercana a cero huevos/cm3 de sustrato como población inicial, y que el almácigo se debe desarrollar libre de nematodos, ya que aún con Pi bajas se puede alcanzar la máxima población en corto tiempo.

    7. Computational study of fluid flow and heat transfer in composite packed beds of spheres with low tube to particle diameter ratio

      Energy Technology Data Exchange (ETDEWEB)

      Yang, Jian, E-mail: yangjian81@mail.xjtu.edu.cn [Key Laboratory of Thermo-Fluid Science and Engineering, Ministry of Education, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China); Wu, Jiangquan [CSR Research of Electrical Technology and Material Engineering, Zhuzhou, Hunan 412001 (China); Zhou, Lang; Wang, Qiuwang [Key Laboratory of Thermo-Fluid Science and Engineering, Ministry of Education, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049 (China)

      2016-04-15

      Highlights: • Flow and heat transfer in composite packed beds with low d{sub t}/d{sub pe} are investigated. • The wall effect would be restrained with radially layered composite packing (RLM). • Heat flux and overall heat transfer efficiency can be improved with RLM packing. - Abstract: The effect of the tube wall on the fluid flow and heat transfer would be important in the packed bed with low tube to particle diameter ratio, which may lead to flow and temperature maldistributions inside, and the heat transfer performance may be lowered. In the present paper, the flow and heat transfer performances in both the composite and uniform packed beds of spheres with low tube to particle diameter were numerically investigated, where the composite packing means randomly packing with non-uniform spheres and the uniform packing means randomly packing with uniform spheres, including radially layered composite packing (RLM), axially layered composite packing (ALM), randomly composite packing (RCM) and randomly uniform packing (RPM). Both the composite and uniform packings were generated with discrete element method (DEM), and the influence of the wall effect on the flow and heat transfer in the packed beds were carefully studied and compared with each other. Firstly, it is found that, the wall effect on the velocity and temperature distributions in the randomly packed bed of uniform spheres (RPM) with low tube to particle diameter ratio were obvious. The average velocity of the near-tube-wall region is higher than that of the inner-tube region in the bed. When the tube wall is adiabatic, the average temperature of the near-tube-wall region is lower. With radially layered composite packing method (RLM), smaller pores would be formed close to the tube wall and big flow channels would be formed in the inner-tube region of the bed, which would be benefit to restrain the wall effect and improve heat transfer in the bed with low tube to particle diameter ratio. Furthermore, it

    8. Agri-spillways as soil erosion protection tools in conventional sloping vineyards (Montes de Málaga, Spain)

      Science.gov (United States)

      Rodrigo-Comino, Jesús

      2017-04-01

      Rainfall causes soil erosion on Mediterranean sloping vineyards (>25˚ of slope inclination), however, little is known about information related to cheap, effective and suitable soil erosion protection measures. In the vineyards of the Montes de Málaga (southern Spain), a concrete land management practice against soil erosion is actually conducted by building tilled rills to down-slope direction to canalize water and sediments. We decided to call them agri-spillways. In this study, by carrying out runoff experiments, we assessed two agri-spillways (from 10 m to 15 m length) under extreme conditions. A motor driven pump mobilizes a constant water inflow about of 1.33 L s-1during between 12 and 15 minutes (≈1000 litres). Finally, we observed: i) a high capacity of these agri-spillways to canalize a large volume of water and sediments; and, ii) higher speed of water flow (from 0.16 m s-1to 0.28 m s-1) and sediment concentration (SC) rates with ratios up to 1538.6 g l-1). By comparing among them, the speed of water flow and the SC were much higher in one of tested rills, which was 5 meters length less and 7 degrees more of inclination. So, we concluded that these agri-spillways, after correctly planning and long term maintenance from contribution area to down-slope direction, can be function as a potential tool for designing suitable and cheap plans to protect the soil in Mediterranean sloping vineyards. Acknowledgements Firstly, we acknowledge the farmer's syndicate UPA (Unión de Pequeños Agricultores) and the wine-grower Pepe Gámez (Almáchar) for providing access to the study area. Secondly, we thank the students of the Bachelor course and Master from Trier University for their hard efforts in the field and laboratory works in the Almáchar campaign. Thirdly, we acknowledge the geomorphology and soil laboratory technicians María Pedraza and Rubén Rojas of GSoilLab (Málaga University) for the soil analysis. Finally, we also thank the Ministerio de Educaci

    9. Reseñas de Libros

      Directory of Open Access Journals (Sweden)

      José Antonio Ruiz Gil

      2009-12-01

      Full Text Available Beck, Ulrich; Grande, Edgar, La Europa Cosmopolita. Sociedad y Política en la Segunda Modernidad. Barcelona, Paidós, 2006, 392 pp.Páginas 187-189José Antonio Ruiz GilCastells, Manuel (ed., La sociedad red: una visión global. Madrid, Alianza Editorial, 2006, 558 pp.Páginas 189-191David Molina RabadánCuenca Toribio, José Manuel, Nacionalismo, Franquismo y Nacionalcatolicismo. Madrid, Editorial Actas, 2008, 220 pp.Páginas 191-193Ricardo Martín de la GuardiaDiamond, Jared, Colapso, Por qué unas sociedades perduran y otras desaparecen. Madrid, Debate, 2006, 854 pp.Páginas 193-195Daniel Alcalde GüelfoFumaroli, Marc, El Estado cultural (ensayo sobre una religión moderna. Barcelona, Acantilado, 2007, 147 pp.Páginas 195-197José Antonio Ruiz GilGarí, Manuel; Pastor, Jaime y Romero, Miguel (eds., 1968. El mundo pudo cambiar de base. Madrid, Los Libros de la Catarata, 2008, 365 pp.Páginas 197-199Ana Domínguez RamaMann, James, Los Vulcanos. El gabinete de guerra de Bush: Cheney, Powell, Rumsfeld, Rice, Wolfowitz, Armitage. Granada, Almed, 2007, 498 pp.Páginas 199-201David Molina RabadánMartín Muñoz, Gema, Iraq. Un fracaso de Occidente (1920-2003. Barcelona, Tusquets, 2003, 323 pp.Páginas 201-202José María Torrente GisbertMuñoz Aunión, Antonio, La política común europea de derecho de asilo. Valencia, Tirant Lo Blanc. 2007, 268 pp.Páginas 202-205José Joaquín Fernández AllesRey Tristán, Eduardo (dir., Memorias de la violencia en Uruguay y Argentina. Golpes, dictaduras, exilios (1973-2006. Santiago de Compostela, Universidad de Santiago de Compostela-CIEAM, 2007, 382 pp.Páginas 205-206Silvina JensenShlaim, Avi, El Muro de Hierro. Israel y el mundo árabe. Granada, Almed, 2003, 778 pp.Páginas 207-208José María Torrente GisbertWallerstein, Immanuel, Utopística o las opciones históricas del siglo XXI. Madrid, Siglo XXI Editores, 1998, 91 pp.Páginas 208-209Manuel Pérez Salinas

    10. Inhibition by Seeds of Phalaris canariensis Extracts of Key Enzymes Linked to Obesity.

      Science.gov (United States)

      Perez Gutierrez, Rosa Martha; Madrigales Ahuatzi, Diana; Cruz Victoria, Teresa

      2016-01-01

      Obesity and its associated diseases are an increasing problem around the world. One hyperglycemic remedy is reduction of glucose absorption performed by suppressing digestion of carbohydrates and lipids through the use of inhibitors. Phalaris canariensis (P canariensis) is a species belonging to the Graminaceae family and is used in traditional medicine in Mexico for treatment of diabetes and obesity. The aim of the study was to evaluate the effects of different extracts of the seeds of P canariensis on enzymes metabolizing fat and carbohydrates, obtained using 3 solvents. The seeds of P canariensis were extracted using hexane (ALH), chloroform (ALC), and methanol (ALM) and were investigated for their antiobesity potential. This research was conducted in the Laboratory of Research of Natural Products in the School of Chemical Engineering at the National Polytechnic Institute and in the Research Laboratory of Enzymology in the National School of Biological Sciences. Different concentrations of the extracts were used to study the inhibition of enzymatic activity by porcine pancreatic α-amylase, with carbose as a positive control. The inhibitory activity of α-glucosidase was determined using the standard method with bovine serum albumin (BSA). Pancreatic lipase (PL) activity was measured by absorbance at 412 nm, and the data obtained were compared with orlistat. The PL activity was assessed using a second method measuring the rate of release of oleic acid from triolein. Lipoprotein lipase (LPL) activity was measured by released (3H)-oleic acid. Lipolytic activity in cultured, mouse, 3T3-Ll adipocytes was used as a measure of hormone-sensitive lipase activity. The inhibitory activity of rat intestinal sucrase was determined by measuring the glucose released. A Caco-2 cell assay determined the content of free glucose. The ALH extract of P canariensis showed potent inhibitory activity with IC50 values of 2.13 and 1.25 mg/mL as compared with α-amylase and

    11. Digital Gaming for Improving the Functioning of People With Traumatic Brain Injury: Randomized Clinical Feasibility Study.

      Science.gov (United States)

      Välimäki, Maritta; Mishina, Kaisa; Kaakinen, Johanna K; Holm, Suvi K; Vahlo, Jukka; Kirjonen, Markus; Pekurinen, Virve; Tenovuo, Olli; Korkeila, Jyrki; Hämäläinen, Heikki; Sarajuuri, Jaana; Rantanen, Pekka; Orenius, Tage; Koponen, Aki

      2018-03-19

      . However, depression scores increased significantly between baseline and after 8 weeks and between baseline and after 3 months in the rehabilitative gaming group. No differences were found in patients' self-efficacy between the three measuring points in any of the groups. Participants did use the games (rehabilitation group: 93%, 27/29; entertainment group 100%, 29/29). Games were seen as a usable intervention (rehabilitation group: 70%, 14/29; entertainment group: 83%, 20/29). The rehabilitation group was less satisfied with the gaming intervention (68%, 13/29 vs 83%, 20/29), but they were more willing to use the game after the intervention period (76%, 16/29 vs 63%, 15/29). Total time spent on gaming during the intervention period was low (15.22 hour rehabilitation gaming group, 19.22 hour entertainment gaming group). We did not find differences between the groups in improvement in the outcome measures. The improvements in test performance by all three groups may reflect rehearsal effects. Entertainment gaming had elements that could be considered when rehabilitative games are designed for, implemented in, and assessed in larger clinical trials for persons with TBI. ClinicalTrials.gov NCT02425527; https://clinicaltrials.gov/ct2/show/NCT02425527 (Archived by WebCite at http://www.webcitation.org/6esKI1uDH). ©Maritta Välimäki, Kaisa Mishina, Johanna K Kaakinen, Suvi K Holm, Jukka Vahlo, Markus Kirjonen, Virve Pekurinen, Olli Tenovuo, Jyrki Korkeila, Heikki Hämäläinen, Jaana Sarajuuri, Pekka Rantanen, Tage Orenius, Aki Koponen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 19.03.2018.

    12. Safety Experts Complete IAEA Nuclear Regulatory Review of the United States

      International Nuclear Information System (INIS)

      2010-01-01

      Full text: An international team of senior nuclear safety experts today completed a two-week International Atomic Energy Agency (IAEA) review of the governmental and regulatory framework for nuclear safety in the United States. The team identified good practices within the U.S. system and offered suggestions for ways the U.S. Nuclear Regulatory Commission (NRC) could improve. The IAEA has conveyed the team's main conclusions to the NRC, and a final report will be submitted to the NRC in about two months. At the request of the United States, the IAEA assembled a team of 19 international experts to conduct an Integrated Regulatory Review Service (IRRS) mission. This mission was a peer review based on the IAEA Safety Standards. It was not an inspection, nor an audit. The experts came from 14 different countries: Canada, China, the Czech Republic, Finland, France, Italy, Japan, Mexico, the Republic of Korea, Slovenia, Spain, Sweden, Switzerland, and the United Kingdom. Team leader Jukka Laaksonen of Finland said: ''We found a comprehensive, consistent, and mature regulatory system run by the NRC, which has a strong drive for continuous improvement.' The scope of the mission included the U.S. regulatory framework and the regulation of the nuclear plant operation. The mission was conducted from 18 to 29 October, mainly at NRC headquarters outside of Washington, D.C. To study U.S. regulatory activities, the mission conducted a series of interviews and discussions with NRC staff and other organizations to help assess the effectiveness of the regulatory system. In addition, the team observed regulatory activities at two operating nuclear power reactors and an emergency preparedness exercise. The IAEA's IRRS coordinator Gustavo Caruso said, ''This mission represents a milestone for the IRRS program because the U.S. regulatory system is the largest in the world and many nations look to it. The IRRS is a useful tool that allows host nations to gain guidance from experienced

    13. Working Together: How Teachers Teach and Students Learn in Collaborative Learning Environments

      Directory of Open Access Journals (Sweden)

      Mary Burns

      2014-01-01

      Full Text Available Active Learning in Maths and Science (ALMS was a six-month face-to-face professional development program for middle school maths and science teachers carried out between June and November, 2010 in two Indian states. ALMS’s theory of action is grounded in the belief that collaborative learning serves as a “gateway” to learner-centered instruction. Designers theorized that this shift from individual to collaborative learning would redefine the teacher’s role; alter the teacher and student relationship; change teachers’ organizational, instructional and assessment practices; and begin to lay the groundwork for an eventual shift toward full learner-centered instruction. As this paper will discuss, this proposed theory of action was largely confirmed. Over 80 percent of teachers across the two states regularly implemented collaborative learning techniques and began the larger journey toward learner-centered instruction. This implementation also resulted in a number of benefits for students, including greater levels of engagement, increased confidence, and improved behavior. The research also suggests that when teachers see positive changes as a result of their actions, their deeply-held beliefs about traditional instruction may conflict with what they in fact witnessed in their classrooms. This is the beginning of the evolution of change.

    14. Proceedings of the Northwest regional energy conference

      Energy Technology Data Exchange (ETDEWEB)

      Denman, A S; Comstock, D R [eds.

      1978-12-01

      The conference was directed toward two main objectives. First, a major portion of the proceedings were to focus on the policies, programs, and priorities of the new US DOE, and their relationships to the Pacific Northwest region. Second, the conference was to explore specific energy issues of regional significance and provide an opportunity for regional feedback on energy policies. The 10 sessions of the conference are Keynote Session: Congress, and the National Energy Plan Sen. Henry Jackson; National Perspectives on Energy Issues (I): An Overview of the NEP, Programs and Priorities of DOE (Alvin Alm and NEP - Conservation and Solar Applications (Don Beattie); and Luncheon address - Alaska Energy Issues (Robert LeResche); National Perspectives on Energy Issues (II): Utility Rate Reform - National Provisions and Relationships to the Pacific Northwest (David Bardin) and Technology for Energy and Long Term Short Alternatives (Robert Thorne); Concurrent Interest Group Sessions: State and Local Roles in Energy Planning and Decision-Making and Industry and University Roles in DOE Research and Programs; Banquet address. The US Energy Future (James Schlesinger); Regional Perspectives on Energy Issues: DOE-X - Organization and Response to Regional Needs (Randall Hardy). What Comes After Number 13 (Sterling Munro), Hanford 1978 (Alex Fremling), and Low Head Hydro and Geothermal (Richard Wood); Lucheon address - The Washington Perspective on Energy (Dixie Lee Ray); Regional Power Planning (Panel); and Conference Wrap Up Session. (MCW)

    15. Advanced light microscopy core facilities: Balancing service, science and career

      Science.gov (United States)

      Hartmann, Hella; Reymann, Jürgen; Ansari, Nariman; Utz, Nadine; Fried, Hans‐Ulrich; Kukat, Christian; Peychl, Jan; Liebig, Christian; Terjung, Stefan; Laketa, Vibor; Sporbert, Anje; Weidtkamp‐Peters, Stefanie; Schauss, Astrid; Zuschratter, Werner; Avilov, Sergiy

      2016-01-01

      ABSTRACT Core Facilities (CF) for advanced light microscopy (ALM) have become indispensable support units for research in the life sciences. Their organizational structure and technical characteristics are quite diverse, although the tasks they pursue and the services they offer are similar. Therefore, throughout Europe, scientists from ALM‐CFs are forming networks to promote interactions and discuss best practice models. Here, we present recommendations for ALM‐CF operations elaborated by the workgroups of the German network of ALM‐CFs, German Bio‐Imaging (GerBI). We address technical aspects of CF planning and instrument maintainance, give advice on the organization and management of an ALM‐CF, propose a scheme for the training of CF users, and provide an overview of current resources for image processing and analysis. Further, we elaborate on the new challenges and opportunities for professional development and careers created by CFs. While some information specifically refers to the German academic system, most of the content of this article is of general interest for CFs in the life sciences. Microsc. Res. Tech. 79:463–479, 2016. © 2016 THE AUTHORS MICROSCOPY RESEARCH AND TECHNIQUE PUBLISHED BY WILEY PERIODICALS, INC. PMID:27040755

    16. AMERİKA BİRLEŞİK DEVLETLERİ’NDE DEVLETİN YENİDEN YAPILANDIRILMASINA YÖNELİK UYGULAMALAR (Clinton-Al Gore Girişimi: 1993-2001)

      OpenAIRE

      Aktan, Coşkun Can

      2018-01-01

      ABD’nde devletin yeniden yapılandırılması çalışmaları William Clinton’un başkanlığı döneminde Başkan Yardımcılığı görevini yürüten Al Gore öncülüğünde yürütülmüştür. ABD’nde bu amaçla National Performance Review adlı bir de yeniden yapılandırma laboratuvarı kurulmuştur. Bu kurum daha sonra National Partnership for Reinventing Government adını almıştır. Bu çalışmada 1993-2001 yılları arasında ABD’nde devletin yeniden yapılandırılmasına yönelik uygulamalar incelenmektedir....

    17. Sacerdos vs. Episcopus. The employment of the Treatise de septem ordinibus ecclesiae by Isidore of Seville (a source study

      Directory of Open Access Journals (Sweden)

      Elena Marey

      2018-12-01

      Full Text Available The aim of this article is to reveal the methods and characteristic features of Isidore of Seville’s interpretation of the anonymous text De septem ordinibus ecclesiae (5th — early 7th centuries. This text, traditionally attributed to St. Jerome, deals with the functions of church servants and clerics. Isidore reinterprets it in the second part of his book De ecclesiasticis offi ciis, also devoted to the origin and functions of clerics. Isidore often makes use of the text of his predecessor but almost never quotes the borrowed sentences completely and unchanged. The text of Ps.-Jerome was used by Isidore as a set of rhetorical patterns which he needed in order to express his own ideas. Thus, Isidore reinterprets the concept of sacerdos: in his text it is, fi rst of all, the bishop. Besides, Isidore fi lls the image of the bishop with new content; it is signifi cant that Isidore uses only the prologue from Ps.-Jerome’s text, rather than a specifi c chapter devoted to bishops. Isidore’s sacerdos, as opposed to the episcopus of Ps.-Jerome, is actively involved in the life of the Christian community: he preaches, instructs the fl ock, gives alms, takes part in legal proceedings and performs the sacraments.

    18. دور نظام الوقف الإسلامي في تلبية حاجيات المجتمع الأمنية في الأندلس على ضوء كتاب المعيار للونشريسي

      Directory of Open Access Journals (Sweden)

      محمد،زاهي

      2013-03-01

      Full Text Available When Islam came, the Waqf began and expanded its circle. It did not limit it to temples and rituals, but extended it to include many types of alms and donations that are monitored for religious, social, scientific and economic purposes. The endowments were on mosques and their maintenance and functions, schools, educational institutions, libraries, angles, scientists and students of science, and the poor and the needy. It has expanded to include hospitals and pharmacies, social welfare homes, the marriage of needy girls and boys, rivers and boreholes, the establishment of laces and fortresses, the creation of weapons and equipment to protect the House of Islam and defend its citizens. Such endowments spread in Andalusia, especially during the period of the Spanish renaissance wars in the northern regions of the Thorour. It was necessary to stay on the holes and fortifications and drilling wells and horses and weapons for the Muslim Mujahedeen. The ligaments were built everywhere in Andalusia and Maghreb. These endowments were a particular good for Jihad and the protection of the gaps by building bridges and centers in the areas of contact with the enemy. In the Miar of the Wancharissi , there were several areas for the Waqf. The owners stood in favor of the thugs and bonds in the north of Andalusia. A great virtue and a benign influence in building Islamic civilization and laying the foundation for integration, cooperation and brotherhood.

    19. Contractor report to the Department of Energy on opportunities for integration of environmental management activities across the complex (predecisional draft). Revision 1

      International Nuclear Information System (INIS)

      1997-03-01

      The US Department of Energy (DOE) Environmental Management (EM) program faces significant technical and financial challenges in cleaning up the environmental legacy of nuclear weapons production and research and development, while facing an uncertain future in obtaining the needed funding to perform this work. Many of these requirements, including State and Federal regulations and negotiated agreements, continue to be a significant contributor to EM program costs and schedules. Historically, the sites have managed their programs focusing on their individual site's needs. While this approach maximized successes at individual sites, it has resulted in a more costly program than if more integration across the DOE system occurred. In July 1996, the DOE Assistant Secretary for EM, Al Alm, chartered a contractor led effort to perform complex-wide integration in support of the ten-year plan process to develop a suite of technically defensible, integrated alternatives to meet the EM mission. This report documents opportunities for waste and nuclear materials management integration activities in six areas: transuranic (TRU) waste, mixed low-level waste (MLLW), low-level waste (LLW), environmental restoration (ER), high-level waste (HLW), and spent nuclear fuel (SNF). The opportunities represent technically defensible solutions which reduce cost, accelerate schedules, and result in no significant increase in risk

    20. Effect of location on microstructure and mechanical properties of additive layer manufactured Inconel 625 using gas tungsten arc welding

      Energy Technology Data Exchange (ETDEWEB)

      Wang, J.F. [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Shandong Provincial Key Laboratory of Special Welding Technology, Harbin Institute of Technology at Weihai, Weihai 264209 (China); Sun, Q.J., E-mail: qjsun@hit.edu.cn [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Shandong Provincial Key Laboratory of Special Welding Technology, Harbin Institute of Technology at Weihai, Weihai 264209 (China); Wang, H. [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Liu, J.P. [Shandong Provincial Key Laboratory of Special Welding Technology, Harbin Institute of Technology at Weihai, Weihai 264209 (China); China Nuclear Industry 23 Construction Co., Ltd., Beijing 101300 (China); Feng, J.C. [State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001 (China); Shandong Provincial Key Laboratory of Special Welding Technology, Harbin Institute of Technology at Weihai, Weihai 264209 (China)

      2016-10-31

      Additive layer manufacturing (ALM), using gas tungsten arc welding (GTAW) as heat source, is a promising technology in producing Inconel 625 components due to significant cost savings, high deposition rate and convenience of processing. With the purpose of revealing how microstructure and mechanical properties are affected by the location within the manufactured wall component, the present study has been carried out. The manufactured Inconel 625 consists of cellular grains without secondary dendrites in the near-substrate region, columnar dendrites structure oriented upwards in the layer bands, followed by the transition from directional dendrites to equiaxed grain in the top region. With the increase in deposited height, segregation behavior of alloying elements Nb and Mo constantly strengthens with maximal evolution in the top region. The primary dendrite arm spacing has a well coherence with the content of Laves phase. The microhardness and tensile strength show obvious variation in different regions. The microhardness and tensile strength of near-substrate region are superior to that of layer bands and top region. The results are further explained in detail through the weld pool behavior and temperature field measurement.

    1. Let's Make Data Count

      Science.gov (United States)

      Budden, A. E.; Abrams, S.; Chodacki, J.; Cruse, P.; Fenner, M.; Jones, M. B.; Lowenberg, D.; Rueda, L.; Vieglais, D.

      2017-12-01

      The impact of research has traditionally been measured by citations to journal publications and used extensively for evaluation and assessment in academia, but this process misses the impact and reach of data and software as first-class scientific products. For traditional publications, Article-Level Metrics (ALM) capture the multitude of ways in which research is disseminated and used, such as references and citations within social media and other journal articles. Here we present on the extension of usage and citation metrics collection to include other artifacts of research, namely datasets. The Make Data Count (MDC) project will enable measuring the impact of research data in a manner similar to what is currently done with publications. Data-level metrics (DLM) are a multidimensional suite of indicators measuring the broad reach and use of data as legitimate research outputs. By making data metrics openly available for reuse in a number of different ways, the MDC project represents an important first step on the path towards the full integration of data metrics into the research data management ecosystem. By assuring researchers that their contributions to scholarly progress represented by data corpora are acknowledged, data level metrics provide a foundation for streamlining the advancement of knowledge by actively promoting desirable best practices regarding research data management, publication, and sharing.

    2. Wake Flow Simulation of a Vertical Axis Wind Turbine Under the Influence of Wind Shear

      Science.gov (United States)

      Mendoza, Victor; Goude, Anders

      2017-05-01

      The current trend of the wind energy industry aims for large scale turbines installed in wind farms. This brings a renewed interest in vertical axis wind turbines (VAWTs) since they have several advantages over the traditional Horizontal Axis Wind Tubines (HAWTs) for mitigating the new challenges. However, operating VAWTs are characterized by complex aerodynamics phenomena, presenting considerable challenges for modeling tools. An accurate and reliable simulation tool for predicting the interaction between the obtained wake of an operating VAWT and the flow in atmospheric open sites is fundamental for optimizing the design and location of wind energy facility projects. The present work studies the wake produced by a VAWT and how it is affected by the surface roughness of the terrain, without considering the effects of the ambient turbulence intensity. This study was carried out using an actuator line model (ALM), and it was implemented using the open-source CFD library OpenFOAM to solve the governing equations and to compute the resulting flow fields. An operational H-shaped VAWT model was tested, for which experimental activity has been performed at an open site north of Uppsala-Sweden. Different terrains with similar inflow velocities have been evaluated. Simulated velocity and vorticity of representative sections have been analyzed. Numerical results were validated using normal forces measurements, showing reasonable agreement.

    3. Fifty Years of Burn Care at Shriners Hospitals for Children, Galveston.

      Science.gov (United States)

      Čapek, Karel D; Culnan, Derek M; Desai, Manubhai H; Herndon, David N

      2018-03-01

      More than 50 years ago, Shriners Hospitals for Children expanded their philanthropy to include care for burned children. In so doing, the effects of their work weightily expanded from rehabilitation and quality of life outcomes to include survival proper. As the first facility dedicated to the care of burned children, originally designated the Shriners Burn Institute, the Galveston hospital remains the cornerstone of this endeavor. Shriners maintains charitable pediatric hospitals, provide care irrespective of the patient's or the family's ability to pay, and promote research. The sole criterion for admission at Shriners Hospitals for Children is the determination by a surgeon at a Shriners hospital that "the child's trouble may be corrected or improved." This philanthropic effort to provide medical care for children is one expression of the human commonality recognized by Shriners. In this article, we provide some background information on how this hospital came into existence as well as a global summary of its interventions toward greater survival and more complete rehabilitation of burned children. Based on the findings presented herein, we assert that there is less suffering and less loss of life due to childhood burns today than in previous years. We attribute much of this improvement to the simple voluntary collective decision by Shriners to provide alms for burned children.

    4. Brazilian medicinal plants used by the Dr. João Ferreyra da Rosa according to his “Treatise on Pestilence in Pernambuco” at the end of the 17th century

      Directory of Open Access Journals (Sweden)

      Érika Alves Tavares Marques

      2008-12-01

      Full Text Available João Ferreyra da Rosa’s “Treatise on Pestilence in Pernambuco”, published in 1694 was the first document on yellow fever, its symptoms and treatment, and it described the phytomedicines used at the time. Rosa described a hundred medicinal plants used to treat the epidemic; most of them came already prepared from Europe, since the majority of Portuguese physicians rejected the indigenous therapeutic knowledge. However, later, due to the lenght and adverse conditions of maritime trevel, leading to losses in the effectiveness of the active ingredients of such phytotherapeutic products, doctors were obliged to employ native medicinal plants in their treatments. The Brazilian medicinal plants used in the treatment of the first epidemic of yellow fever in Brazil (17th century had been brought up to date from the taxonomic point of view, and were comparable with those used in popular medicine today. As part of the phytotherapeutic treatment of yellow fever at the end of the 17th century, Rose made use of the following medicinal plants: copaíba, macela, maracujá-mirim, red aroeira, angélico and almécega.

    5. Processamento correferencial de nomes e pronomes do português brasileiro em pessoas portadoras de gagueira = Coreferential processing of nouns and pronouns in Brazilian Portuguese by people with stuttering

      Directory of Open Access Journals (Sweden)

      Correia, Débora Vasconcelos

      2013-01-01

      Full Text Available Este trabalho apresenta os resultados de uma pesquisa experimental sobre o processamento da correferência em pessoas que gaguejam (PQG e falantes fluentes (FF de Português Brasileiro (PB, além de refletir sobre a possibilidade de associação entre a gagueira e a presença de dificuldades na memória procedimental, a partir da relação entre o Modelo Pré-Motor Duplo de Alm (2005 e o Modelo Declarativo/Procedimental de Ullman (2001. Lança-se, então, uma hipótese acerca da conexão entre a presença de disfunções na memória procedimental e o processamento linguístico das PQG, investigada através de um experimento de leitura automonitorada. Os resultados encontrados sugerem que não existe diferença no processamento anafórico de nomes e pronomes do PB entre PQG e FF, uma vez que ambos os grupos apresentaram padrões semelhantes no tempo médio de leitura. A sequência da pesquisa aponta para a necessidade de se investigar este fenômeno em nível intrassentencial, a fim de isolar o aspecto gramatical e eliminar as possíveis interferências dos fatores pragmáticos e contextuais

    6. Fonksiyonel konstipasyonu olan yetişkin bireylerin beslenme durumlarının değerlendirilmesi

      OpenAIRE

      Ateş, Burcu

      2015-01-01

      Bu çalışma, fonksiyonel konstipasyon tanısı alan yetişkin bireylerin beslenme durumlarının değerlendirilmesi amacı ile yapılmıştır. Çalışma Başkent Üniversitesi Tıp ve Sağlık Bilimleri Araştırma Kurulu Etik Kurul Kararı alındıktan sonraki 3 ay içerisinde, Bayındır Söğütözü Hastanesi Gastroenteroloji Polikliniği’ne başvuran konstipasyon tanısı almış, 19-64 yaş arası, 59’u kadın, 26’sı erkek 85 hasta üzerinde yürütülmüştür. Hastaların demografik özellikleri, beslenme alışkanlıkları, fiziksel ak...

    7. High Temperature Deformation Mechanisms in a DLD Nickel Superalloy

      Directory of Open Access Journals (Sweden)

      Sean Davies

      2017-04-01

      Full Text Available The realisation of employing Additive Layer Manufacturing (ALM technologies to produce components in the aerospace industry is significantly increasing. This can be attributed to their ability to offer the near-net shape fabrication of fully dense components with a high potential for geometrical optimisation, all of which contribute to subsequent reductions in material wastage and component weight. However, the influence of this manufacturing route on the properties of aerospace alloys must first be fully understood before being actively applied in-service. Specimens from the nickel superalloy C263 have been manufactured using Powder Bed Direct Laser Deposition (PB-DLD, each with unique post-processing conditions. These variables include two build orientations, vertical and horizontal, and two different heat treatments. The effects of build orientation and post-process heat treatments on the materials’ mechanical properties have been assessed with the Small Punch Tensile (SPT test technique, a practical test method given the limited availability of PB-DLD consolidated material. SPT testing was also conducted on a cast C263 variant to compare with PB-DLD derivatives. At both room and elevated temperature conditions, differences in mechanical performances arose between each material variant. This was found to be instigated by microstructural variations exposed through microscopic and Energy Dispersive X-ray Spectroscopy (EDS analysis. SPT results were also compared with available uniaxial tensile data in terms of SPT peak and yield load against uniaxial ultimate tensile and yield strength.

    8. Effect of location on microstructure and mechanical properties of additive layer manufactured Inconel 625 using gas tungsten arc welding

      International Nuclear Information System (INIS)

      Wang, J.F.; Sun, Q.J.; Wang, H.; Liu, J.P.; Feng, J.C.

      2016-01-01

      Additive layer manufacturing (ALM), using gas tungsten arc welding (GTAW) as heat source, is a promising technology in producing Inconel 625 components due to significant cost savings, high deposition rate and convenience of processing. With the purpose of revealing how microstructure and mechanical properties are affected by the location within the manufactured wall component, the present study has been carried out. The manufactured Inconel 625 consists of cellular grains without secondary dendrites in the near-substrate region, columnar dendrites structure oriented upwards in the layer bands, followed by the transition from directional dendrites to equiaxed grain in the top region. With the increase in deposited height, segregation behavior of alloying elements Nb and Mo constantly strengthens with maximal evolution in the top region. The primary dendrite arm spacing has a well coherence with the content of Laves phase. The microhardness and tensile strength show obvious variation in different regions. The microhardness and tensile strength of near-substrate region are superior to that of layer bands and top region. The results are further explained in detail through the weld pool behavior and temperature field measurement.

    9. SİGORTA SEKTÖRÜNDE RİGOR MORTİS (ÖLÜM KATILIĞI) ve DEĞİŞİM FAALİYETLERİNİN ANALİZİ

      OpenAIRE

      URALCAN, Güler

      2014-01-01

      Sigorta sektörü ekonomi içindeki önemine rağmen, ülkemizde gereken ilgiyi yüzlerce yıl bulamamıştır. Onlarca yıldan beri uluslar arası karşılaştırmaların yapıldığı ekonomik göstergelerin tümünde, Türk sigorta sektörü dünya ülkeleri içinde en son birkaç ülke arasında yer almıştır. 21. yüzyılın başına dek yaşanan gelişmelere bakıldığında sektörde sigortacılık işlemlerinin yürütülebildiği ancak üretimin yeterince artırılamadığı, yeterli mali gücün sağlanamadığı, dolayısıyla sigortacılığın sosyo-...

    10. HATTAT MUSTAFA HALİM ÖZYAZICI ve TUTTUĞU TALEBE KAYIT DEFTERLERİ

      OpenAIRE

      Berk, süleyman

      2015-01-01

      ÖZETOsmanlı’dan Cumhuriyet dönemine intikal eden önemli hattatlarımızdan biri de Mustafa HalimÖzyazıcı’dır (1315/1898- 1384/1964). Halim Efendi, hat sanatının zirveye çıktığı dönemde ünlü sanatkârlardanders almıştır. Sanat bakımından, “Kalemi kendine esir etmiş ve yazıyı yenmiş” kudretli hattatlarımızdanbirisidir. Her çeşit yazıda mükemmel eserler vermiştir. Kendisinin klasik anlamda icazetiolmamasına rağmen mezun olduğu Medresetü’l-Hattâtîn’den aldığı diplomada ders aldığı hocalarınınimzası ...

    11. Microlayered flow structure around an acoustically levitated droplet under a phase-change process.

      Science.gov (United States)

      Hasegawa, Koji; Abe, Yutaka; Goda, Atsushi

      2016-01-01

      The acoustic levitation method (ALM) has found extensive applications in the fields of materials science, analytical chemistry, and biomedicine. This paper describes an experimental investigation of a levitated droplet in a 19.4-kHz single-axis acoustic levitator. We used water, ethanol, water/ethanol mixture, and hexane as test samples to investigate the effect of saturated vapor pressure on the flow field and evaporation process using a high-speed camera. In the case of ethanol, water/ethanol mixtures with initial ethanol fractions of 50 and 70 wt%, and hexane droplets, microlayered toroidal vortexes are generated in the vicinity of the droplet interface. Experimental results indicate the presence of two stages in the evaporation process of ethanol and binary mixture droplets for ethanol content >10%. The internal and external flow fields of the acoustically levitated droplet of pure and binary mixtures are clearly observed. The binary mixture of the levitated droplet shows the interaction between the configurations of the internal and external flow fields of the droplet and the concentration of the volatile fluid. Our findings can contribute to the further development of existing theoretical prediction.

    12. A study of the Eocene S-type granites of Chapedony metamorphic core complex (northeast of Yazd province, Central Iran)

      International Nuclear Information System (INIS)

      Zakipour, A.; Torabi, Gh.

      2016-01-01

      The Eocene Chapedony metamorphic core complex, is located in western part of the Posht-e-Badam block. This complex is consisting of migmatite, gneiss, amphibolite, marble, micaschist and various types of granitoids. In middle part of this complex (Kalut-e-Chapedony), an Eocene granitic rock unit cross cuts the other rocks. The minerals of this granite are plagioclase (An 9 Ab 8 7O r 4), potassium feldspars (orthoclase), quartz, euhedral garnet (Alm 7 7Sps 1 3Prp 9 Grs 1 ), zircon, apatite, fibrolitic sillimanite and muscovite. Petrology and geochemical studies reveal calc-alkaline, peraluminous and S-type nature of the studied granites. Chondrite-normalized REE patterns represent evident negative anomaly of Eu and low values of the REEs. Continental crust and North American shale composite (NASC) - normalized multi-elements spider diagrams indicate trace elements depletion. These granites are formed by melting of continental crust sedimentary rocks, resulted by emplacement of mantle-derived magma at the bottom of continental crust which formed the Chapedony metamorphic core complex. The source rock of these granites should be a clay-rich sedimentary rock with low amount of plagioclase and CaO/Na 2 O ratio.

    13. Removal of nitrate and sulphate from biologically treated municipal wastewater by electrocoagulation

      Science.gov (United States)

      Sharma, Arun Kumar; Chopra, A. K.

      2017-06-01

      The present investigation observed the effect of current density ( j), electrocoagulation (EC) time, inter electrode distance, electrode area, initial pH and settling time on the removal of nitrate (NO3 -) and sulphate (SO4 2-) from biologically treated municipal wastewater (BTMW), and optimization of the operating conditions of the EC process. A glass chamber of two-liter volume was used for the experiments with DC power supply using two electrode plates of aluminum (Al-Al). The maximum removal of NO3 - (63.21 %) and SO4 2- (79.98 %) of BTMW was found with the optimum operating conditions: current density: 2.65 A/m2, EC time: 40 min, inter electrode distance: 0.5 cm, electrode area: 160 cm2, initial pH: 7.5 and settling time: 60 min. The EC brought down the concentration of NO3 - within desirable limit of the Bureau of Indian Standard (BIS)/WHO for drinking water. Under optimal operating conditions, the operating cost was found to be 1.01/m3 of water in terms of the electrode consumption (23.71 × 10-5 kg Al/m3) and energy consumption (101.76 kWh/m3).

    14. Integrasi Manajemen Asset dan Liabilitas Perbankan Syari’ah

      Directory of Open Access Journals (Sweden)

      Parmujianto Parmujianto

      2017-04-01

      Full Text Available Asset management focus and liability is to coordinate asset-liability portfolio of the bank in order to maximize profits for the banks and the results are distributed to the shareholders in the long term by taking into account liquidity needs and prudence. Prastimoyo (1997 says that the focus or objectives of management of assets and liabilities is to optimize revenue and keep the risk does not exceed the tolerable limit, while also maximizing the market price of the company's equity, while according to Bambang (2000, the management of assets and liabilities has a function and kenijakan in implementing a pricing strategy, both in the areas of lending and funding, in general, the responsibility of ALCO is to manage positions and allocation of funds that banks provided liquidity, maximize profit and minimize risk. On the other hand, Islamic banking has the characteristics berbada with conventional banks which do not recognize interest but for the results except that there are some business activities that exist only on Islamic banking such as trade and pawn so that it impacts extensive technical on banking activities one of which is the management asset-liabilit. So this paper will describe how the ALM policy applied to Islamic banking.

    15. Tiyatro, karikatür ve film provokasyonları bağlamında Fransız basınında İslam ve Hz. Muhammed imajı

      OpenAIRE

      METİN, İsmail

      2016-01-01

      Oryantalizm ve oryantalistler, tarih boyunca İslamı kendi zihin dünyasına göre anlamış ve bu yönde çalışmalar yapmıştır. Yapılan bu çalışmalar ilmi eserler, ansiklopediler, kitaplar, makaleler başta olmak üzere, yazılı ve görsel basında da yer almıştır. Bu makale, oryantalizmin önemli merkezlerinden olan Fransada, özellikle yazılı basında, başta İslam, Kuran-ı Kerim, Hz. Muhammed olmak üzere dini değerlerin medya tarafından algılanış biçimini, karikatür ve film provokasyonları bağlamında tari...

    16. Construction Of A Performance Assessment Model For Zakat Management Institutions

      Directory of Open Access Journals (Sweden)

      Sri Fadilah

      2016-12-01

      Full Text Available The objective of the research is to examine the performance evaluation using Balanced Scorecard model. The research is conducted due to a big gap existing between zakat (alms and religious tax in Islam with its potential earn of as much as 217 trillion rupiahs and the realization of the collected zakat fund that is only reached for three trillion. This indicates that the performance of zakat management organizations in collecting the zakat is still very low. On the other hand, the quantity and the quality of zakat management organizations have to be improved. This means the performance evaluation model as a tool to evaluate performance is needed. The model construct is making a performance evaluation model that can be implemented to zakat management organizations. The organizational performance with Balanced Scorecard evaluation model will be effective if it is supported by three aspects, namely:  PI, BO and TQM. This research uses explanatory method and data analysis tool of SEM/PLS. Data collecting technique are questionnaires, interviews and documentation. The result of this research shows that PI, BO and TQM simultaneously and partially gives a significant effect on organizational performance.

    17. Evaluation of the Benefits Attributable to Automotive Lighweight Materials Program Research and Development Projects

      Energy Technology Data Exchange (ETDEWEB)

      Das, S.

      2002-01-11

      The purpose of this project is to identify and test methods appropriate for estimating the benefits attributable to research and development (R and D) projects funded by the Automotive Lightweight Materials (ALM) Program of the Office of Advanced Automotive Technologies (OAAT) of the U.S. Department of Energy (DOE). The program focuses on the development and validation of advanced lightweight materials technologies to significantly reduce automotive vehicle body and chassis weight without compromising other attributes such as safety, performance, recyclability, and cost. The work supports the goals of the Partnership for a New Generation of Vehicles (PNGV). Up to thirty percent of the improvement required to meet the PNGV goal of tripling vehicle fuel economy and much of its cost, safety, and recyclability goal depend on the lightweight materials. Funded projects range from basic materials science research to applied research in production environments. Collaborators on these projects include national laboratories, universities, and private sector firms, such as leading automobile manufacturers and their suppliers.

    18. Diastereo- and regioselective addition of thioamide dianions to imines and aziridines: synthesis of N-thioacyl-1,2-diamines and N-thioacyl-1,3-diamines.

      Science.gov (United States)

      Shibahara, Fumitoshi; Kobayashi, Shun-ichiro; Maruyama, Toshifumi; Murai, Toshiaki

      2013-01-02

      Addition reactions of thioamide dianions that were derived from N-arylmethyl thioamides to imines and aziridines were carried out. The reactions of imines gave the addition products of N-thioacyl-1,2-diamines in a highly diastereoselective manner in good-to-excellent yields. The diastereomeric purity of these N-thioacyl-1,2-diamines could be enriched by simple recrystallization. The reduction of N-thioacyl-1,2-diamines with LiAlH(4) gave their corresponding 1,2-diamines in moderate-to-good yields with retention of their stereochemistry. The oxidative-desulfurization/cyclization of an N-thioacyl-1,2-diamine in CuCl(2)/O(2) and I(2)/pyridine systems gave the cyclized product in moderate yield and the trans isomer was obtained as the sole product. On the other hand, a similar cyclization reaction with antiformin (aq. NaClO) as an oxidant gave the cis isomer as the major product. The reactions of N-tosylaziridines gave the addition products of N-thioacyl-1,3-diamines with low diastereoselectivity but high regioselectivity and in good-to-excellent yields. The use of AlMe(3) as an additive improved the efficiency and regioselectivity of the reaction. The stereochemistry of the obtained products was determined by X-ray diffraction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

    19. High accuracy magnetic field mapping of the LEP spectrometer magnet

      CERN Document Server

      Roncarolo, F

      2000-01-01

      The Large Electron Positron accelerator (LEP) is a storage ring which has been operated since 1989 at the European Laboratory for Particle Physics (CERN), located in the Geneva area. It is intended to experimentally verify the Standard Model theory and in particular to detect with high accuracy the mass of the electro-weak force bosons. Electrons and positrons are accelerated inside the LEP ring in opposite directions and forced to collide at four locations, once they reach an energy high enough for the experimental purposes. During head-to-head collisions the leptons loose all their energy and a huge amount of energy is concentrated in a small region. In this condition the energy is quickly converted in other particles which tend to go away from the interaction point. The higher the energy of the leptons before the collisions, the higher the mass of the particles that can escape. At LEP four large experimental detectors are accommodated. All detectors are multi purpose detectors covering a solid angle of alm...

    20. El Profesor Académico, Dr. Pablo Gómez Martínez.

      Directory of Open Access Journals (Sweden)

      Zoilo Cuéllar-Montoya

      2007-12-01

      Más adelante, en la misma Presidencia de la Academia del Profesor Pedro José Almánzar Vargas (1963 – 1965, fue promovido Gómez Martínez a la categoría de Miembro de Número(2,10 con el trabajo “Ilio-cisto-plastia con colgajo sero-muscular invertido y reconstrucción de vejigas funcionales” (2,11. En la sesión ordinaria de la Academia del día 12 de marzo de 1964, el Académico Correspondiente Gómez Martínez presentó el trabajo mencionado(2,12 y, en la sesión ordinaria del día 14 de mayo de 1964, en virtud de haber quedado vacantes las sillas de los Señores Académicos de Número Jaime Jaramillo Arango, fallecido en Bogotá, el 31 de julio de 1962(2,13, Manuel José Luque Guevara, retirado por precarias condiciones de salud(2,14, y Fernando Torres Restrepo, trasladado definitivamente a los Estados Unidos(2,15, la Academia, en votación secreta, eligió, como Miembros de Número, a los Señores Académicos Correspondientes Pablo Gómez Martínez, Alfredo Artunduaga y J. Hernando Hernández Garay(2,16...

    1. Hyperkalemic Cardioplegia for Adult and Pediatric Surgery: End of an Era?

      Directory of Open Access Journals (Sweden)

      Geoffrey Phillip Dobson

      2013-08-01

      Full Text Available Despite surgical proficiency and innovation driving low mortality rates in cardiac surgery, the disease severity, comorbidity rate and operative procedural difficulty have increased. Today’s cardiac surgery patient is older, has a sicker heart and often presents with multiple comorbidities; a scenario that was relatively rare 20 years ago. The global challenge has been to find new ways to make surgery safer for the patient and more predictable for the surgeon. A confounding factor that may influence clinical outcome is high K+ cardioplegia. For over 40 years, potassium depolarization has been linked to transmembrane ionic imbalances, arrhythmias and conduction disturbances, vasoconstriction, coronary spasm, contractile stunning, and low output syndrome. Other than inducing rapid electrochemical arrest, high K+ cardioplegia offers little or no inherent protection to adult or pediatric patients. This review provides a brief history of high K+ cardioplegia, five areas of increasing concern with prolonged membrane K+ depolarization, and the basic science and clinical data underpinning a new normokalemic, ‘polarizing’ cardioplegia comprising adenosine and lidocaine (AL with magnesium (Mg2+ (ALM. We argue that improved cardioprotection, better outcomes, faster recoveries and lower healthcare costs are achievable and, despite the early predictions from the stent industry and cardiology, the cath lab may not be the place where the new wave of high-risk morbid patients are best served.

    2. Removal of natural organic matter and arsenic from water by electrocoagulation/flotation continuous flow reactor.

      Science.gov (United States)

      Mohora, Emilijan; Rončević, Srdjan; Dalmacija, Božo; Agbaba, Jasmina; Watson, Malcolm; Karlović, Elvira; Dalmacija, Milena

      2012-10-15

      The performance of the laboratory scale electrocoagulation/flotation (ECF) reactor in removing high concentrations of natural organic matter (NOM) and arsenic from groundwater was analyzed in this study. An ECF reactor with bipolar plate aluminum electrodes was operated in the horizontal continuous flow mode. Electrochemical and flow variables were optimized to examine ECF reactor contaminants removal efficiency. The optimum conditions for the process were identified as groundwater initial pH 5, flow rate=4.3 l/h, inter electrode distance=2.8 cm, current density=5.78 mA/cm(2), A/V ratio=0.248 cm(-1). The NOM removal according to UV(254) absorbance and dissolved organic matter (DOC) reached highest values of 77% and 71% respectively, relative to the raw groundwater. Arsenic removal was 85% (6.2 μg As/l) relative to raw groundwater, satisfying the drinking water standards. The specific reactor electrical energy consumption was 17.5 kWh/kg Al. The specific aluminum electrode consumption was 66 g Al/m(3). According to the obtained results, ECF in horizontal continuous flow mode is an energy efficient process to remove NOM and arsenic from groundwater. Copyright © 2012 Elsevier B.V. All rights reserved.

    3. Visit of Belgian firms at CERN

      CERN Multimedia

      Caroline Laignel - FI

      2006-01-01

      3 - 4 APRIL 2006 9.00 a.m. to 5.00 p.m. Monday 3 April 9.00 a.m. to 5.00 p.m. Tuesday 4 April Individual interviews will take place in technicians' offices. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each departmental secretariat or from the Purchasing web pages at the following URL http://fi-dep.web.cern.ch/fi-dep/structure/memberstates/exhibitions_visits.htm List of Companies: Alcatel Alenia Space Etca ALM ATS Vanwers Cegelec SA Cherokee Europe Cincom Systems International SA DB Engineering BVBA FOS & S BVBA GDM Electronics NV Gemaco SA LMS International NV Management Centre Europe MD Technology Mecasoft SA N.E.T. Research Polmans SA Resarm Engineering Plastics SA Sogeti Belux Syreg SA Tein Telecom SA Groupe Vincott For further information please contact Mrs C. Laignel FI-DI 73722.

    4. Obeticholic Acid Improves Adipose Morphometry and Inflammation and Reduces Steatosis in Dietary but not Metabolic Obesity in Mice

      Science.gov (United States)

      Haczeyni, Fahrettin; Poekes, Laurence; Wang, Hans; Mridha, Auvro R.; Barn, Vanessa; Haigh, W. Geoffrey; Ioannou, George N.; Yeh, Matthew M; Leclercq, Isabelle A.; Teoh, Narcissus C.; Farrell, Geoffrey C.

      2018-01-01

      Objective Non-alcoholic steatohepatitis (NASH) is the outcome of interactions between overnutrition, energy metabolism, and adipose function. Obeticholic acid (OCA) improves steatosis in patients, but for unknown reason does not resolve NASH pathology. We therefore investigated OCA effects in Wt mice which develop obesity with atherogenic dietary feeding, and appetite-dysregulated, Alms1 mutant foz/foz mice fed the same diet which develop metabolic obesity and diabetes. Methods OCA (1mg/kg) was administered orally to female foz/foz mice and Wt littermates from weaning until 28 weeks. We studied adipose indices, glucose tolerance and fatty liver pathology. Experiments were repeated with OCA 10mg/kg. Results OCA reduced body weight and hepatic lipids and improved glucose disposal only in Wt mice. OCA limited Wt adipose expansion, altered morphometry in favour of small adipocytes, enhanced expression of genes indicating adipose browning, and reduced crown-like structure (CLS) number in visceral adipose. foz/foz mice showed more CLSs in all compartments; OCA failed to alter adipose morphometry, browning, inflammation, or improve NASH severity, even at 10mg/kg. Conclusion OCA improves adipose indices, glucose tolerance and steatosis in milder metabolic phenotype, but fails to improve these factors in morbidly obese diabetic mice. These results help explain OCA’s limited efficacy to reverse human NASH. PMID:27804232

    5. Safety Characterization of the Technological Development Plant at Hontomín. Risk Structures: 1. Faults and Fractures

      International Nuclear Information System (INIS)

      Recreo, F.; Hurtado, A.; Eguilior, S.

      2015-01-01

      The safe storage of CO2 requires ensuring seal integrity during the time the CO2 will remain in a supercritical state before dissolving as an aqueous phase, CO2-aq. Geological structures such as faults and fractures that affect storage and seal formations can play an important role in the behaviour of the CO2 plume depending on whether the fracture acts as a barrier to the movement of CO2 or as a preferent conduit. As a consequence, a CO2 geological storage affected by faults or fractures represents a higher degree of uncertainty and its complexity will also be greater for the estimation of the dynamic properties of the flow of CO2 than a not fractured reservoir, increasing uncertainties in assessing both performance and safety In this report an analysis is made on the role that faults and fractures can play on the storage formation flow conditions and on the effects on the behaviour of injected CO2, considering different types of fractures in relation to the fracture inclination angle with the plume flow direction and the fracture conductivity, and presents a simplified model of fracture behaviour in a CO2 storage formation which could be mplemented in the safety assessment probabilistic model that CIUDEN is developing in the framework of the ALM/10/017 project. Finally, an application at the Hontomín site is tested based on the current available geological and geophysical information

    6. ZAKAT COMMUNITY DEVELOPMENT (ZCD DALAM PEMBANGUNAN EKONOMI MASYARAKAT DESA TELUK PAYO KABUPATEN BANYUASIN

      Directory of Open Access Journals (Sweden)

      Rijalush Shalihin

      2016-12-01

      Full Text Available Poverty brings people to “kufr”, which resulted in a lot of people who do not want to implement a series of worship are obliged to do. Social life gradually ignored and no longer cared for in everyday people just thinks how do I get the money to make ends meet. In helping people who cannot afford, arranged in religion as well as helping the poor is by way of charity. “Zakat” should be done to help the poor to the prosperous and independent life. As it is now done program Zakat Community Development (ZCD in Teluk Payo District of Banyuasin II Banyuasin in the development of poor communities in a comprehensive manner by integrating aspects of the economic and social aspects (education, health, religion, environment, and other social aspects that Its main funding comes from “zakat, infaq”, and alms to realize a prosperous society and independent. ZCD program is a program to help poor people improve lives to become prosperous and independent manner to the poor given in accordance with the venture capital skills possessed.

    7. Cardiac magnetic resonance imaging in Alström syndrome

      Directory of Open Access Journals (Sweden)

      Carey Catherine M

      2009-06-01

      Full Text Available Abstract Background A case series of the cardiac magnetic resonance imaging findings in seven adult Alström patients. Methods Seven patients from the National Specialist Commissioning Group Centre for Alström Disease, Torbay, England, UK, completed the cardiac magnetic resonance imaging protocol to assess cardiac structure and function in Alström cardiomyopathy. Results All patients had some degree of left and right ventricular dysfunction. Patchy mid wall gadolinium delayed enhancement was demonstrated, suggesting an underlying fibrotic process. Some degree of cardiomyopathy was universal. No evidence of myocardial infarction or fatty infiltration was demonstrated, but coronary artery disease cannot be completely excluded. Repeat scanning after 18 months in one subject showed progression of fibrosis and decreased left ventricular function. Conclusion Adult Alström cardiomyopathy appears to be a fibrotic process causing impairment of both ventricles. Serial cardiac magnetic resonance scanning has helped clarify the underlying disease progression and responses to treatment. Confirmation of significant mutations in the ALMS1 gene should lead to advice to screen the subject for cardiomyopathy, and metabolic disorders.

    8. Implementation ambiguity: The fifth element long lost in uncertainty budgets for land biogeochemical modeling

      Science.gov (United States)

      Tang, J.; Riley, W. J.

      2015-12-01

      Previous studies have identified four major sources of predictive uncertainty in modeling land biogeochemical (BGC) processes: (1) imperfect initial conditions (e.g., assumption of preindustrial equilibrium); (2) imperfect boundary conditions (e.g., climate forcing data); (3) parameterization (type I equifinality); and (4) model structure (type II equifinality). As if that were not enough to cause substantial sleep loss in modelers, we propose here a fifth element of uncertainty that results from implementation ambiguity that occurs when the model's mathematical description is translated into computational code. We demonstrate the implementation ambiguity using the example of nitrogen down regulation, a necessary process in modeling carbon-climate feedbacks. We show that, depending on common land BGC model interpretations of the governing equations for mineral nitrogen, there are three different implementations of nitrogen down regulation. We coded these three implementations in the ACME land model (ALM), and explored how they lead to different preindustrial and contemporary land biogeochemical states and fluxes. We also show how this implementation ambiguity can lead to different carbon-climate feedback estimates across the RCP scenarios. We conclude by suggesting how to avoid such implementation ambiguity in ESM BGC models.

    9. Numerical simulations of flow fields through conventionally controlled wind turbines and wind farms

      International Nuclear Information System (INIS)

      Yilmaz, Ali Emre; Meyers, Johan

      2014-01-01

      In the current study, an Actuator-Line Model (ALM) is implemented in our in-house pseudo-spectral LES solver SP-WIND, including a turbine controller. Below rated wind speed, turbines are controlled by a standard-torque-controller aiming at maximum power extraction from the wind. Above rated wind speed, the extracted power is limited by a blade pitch controller which is based on a proportional-integral type control algorithm. This model is used to perform a series of single turbine and wind farm simulations using the NREL 5MW turbine. First of all, we focus on below-rated wind speed, and investigate the effect of the farm layout on the controller calibration curves. These calibration curves are expressed in terms of nondimensional torque and rotational speed, using the mean turbine-disk velocity as reference. We show that this normalization leads to calibration curves that are independent of wind speed, but the calibration curves do depend on the farm layout, in particular for tightly spaced farms. Compared to turbines in a lone-standing set-up, turbines in a farm experience a different wind distribution over the rotor due to the farm boundary-layer interaction. We demonstrate this for fully developed wind-farm boundary layers with aligned turbine arrangements at different spacings (5D, 7D, 9D). Further we also compare calibration curves obtained from full farm simulations with calibration curves that can be obtained at a much lower cost using a minimal flow unit

    10. Solution of the Skyrme-Hartree-Fock-Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis. (VII) HFODD (v2.49t): A new version of the program

      International Nuclear Information System (INIS)

      Schunck, Nicolas F.; McDonnell, J.; Sheikh, J.A.; Staszczak, A.; Stoitsov, Mario; Dobaczewski, J.; Toivanen, P.

      2012-01-01

      We describe the new version (v2.49t) of the code HFODD which solves the nuclear Skyrme Hartree-Fock (HF) or Skyrme Hartree-Fock-Bogolyubov (HFB) problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following physics features: (i) the isospin mixing and projection, (ii) the finite temperature formalism for the HFB and HF+BCS methods, (iii) the Lipkin translational energy correction method, (iv) the calculation of the shell correction. A number of specific numerical methods have also been implemented in order to deal with large-scale multi-constraint calculations and hardware limitations: (i) the two-basis method for the HFB method, (ii) the Augmented Lagrangian Method (ALM) for multi-constraint calculations, (iii) the linear constraint method based on the approximation of the RPA matrix for multi-constraint calculations, (iv) an interface with the axial and parity-conserving Skyrme-HFB code HFBTHO, (v) the mixing of the HF or HFB matrix elements instead of the HF fields. Special care has been paid to using the code on massively parallel leadership class computers. For this purpose, the following features are now available with this version: (i) the Message Passing Interface (MPI) framework, (ii) scalable input data routines, (iii) multi-threading via OpenMP pragmas, (iv) parallel diagonalization of the HFB matrix in the simplex breaking case using the ScaLAPACK library. Finally, several little significant errors of the previous published version were corrected.

    11. Crystal structures of titanium–aluminium and –gallium complexes bearing two μ2-CH3 units

      Directory of Open Access Journals (Sweden)

      Tim Oswald

      2017-05-01

      Full Text Available The isotypic crystal structures of two titanocene complexes containing an EMe3 unit (E = Al, Ga; Me = methyl with two μ2-coordinating methyl groups, namely [μ-1(η5-(adamantan-1-yl-2κC1cycylopentadienyl]di-μ2-methyl-methyl-2κC-[1(η5-pentamethylcyclopentadienyl]aluminiumtitanium(III, [AlTi(CH33(C10H15(C15H18], and [μ-1(η5-(adamantan-1-yl-2κC1cycylopentadienyl]di-μ2-methyl-methyl-2κC-[1(η5-pentamethylcyclopentadienyl]galliumtitanium(III, [GaTi(CH33(C10H15(C15H18], are reported. Reacting a dinuclear nitrogen-bridged low-valent titanium(III complex with the Lewis acids AlMe3 or GaMe3 results in the loss of molecular dinitrogen and the formation of two monomeric titanocene(III fragments bearing two μ2-bridging methyl groups. Single crystal X-ray diffraction reveals the formation of a new E—C bond involving the pentafulvene ligand while the bridging and terminal methyl groups remain intact.

    12. Large-eddy simulation of wind turbine wake interactions on locally refined Cartesian grids

      Science.gov (United States)

      Angelidis, Dionysios; Sotiropoulos, Fotis

      2014-11-01

      Performing high-fidelity numerical simulations of turbulent flow in wind farms remains a challenging issue mainly because of the large computational resources required to accurately simulate the turbine wakes and turbine/turbine interactions. The discretization of the governing equations on structured grids for mesoscale calculations may not be the most efficient approach for resolving the large disparity of spatial scales. A 3D Cartesian grid refinement method enabling the efficient coupling of the Actuator Line Model (ALM) with locally refined unstructured Cartesian grids adapted to accurately resolve tip vortices and multi-turbine interactions, is presented. Second order schemes are employed for the discretization of the incompressible Navier-Stokes equations in a hybrid staggered/non-staggered formulation coupled with a fractional step method that ensures the satisfaction of local mass conservation to machine zero. The current approach enables multi-resolution LES of turbulent flow in multi-turbine wind farms. The numerical simulations are in good agreement with experimental measurements and are able to resolve the rich dynamics of turbine wakes on grids containing only a small fraction of the grid nodes that would be required in simulations without local mesh refinement. This material is based upon work supported by the Department of Energy under Award Number DE-EE0005482 and the National Science Foundation under Award number NSF PFI:BIC 1318201.

    13. A Study on the Leakage Characteristic Evaluation of High Temperature and Pressure Pipeline at Nuclear Power Plants Using the Acoustic Emission Technique

      Energy Technology Data Exchange (ETDEWEB)

      Kim, Young Hoon; Kim, Jin Hyun; Song, Bong Min; Lee, Joon Hyun; Cho, Youn Ho [Pusan National University, Busan (Korea, Republic of)

      2009-10-15

      An acoustic leak monitoring system(ALMS) using acoustic emission(AE) technique was applied for leakage detection of nuclear power plant's pipeline which is operated in high temperature and pressure condition. Since this system only monitors the existence of leak using the root mean square(RMS) value of raw signal from AE sensor, the difficulty occurs when the characteristics of leak size and shape need to be evaluated. In this study, dual monitoring system using AE sensor and accelerometer was introduced in order to solve this problem. In addition, artificial neural network(ANN) with Levenberg Marquardt(LM) training algorithm was also applied due to rapid training rate and gave the reliable classification performance. The input parameters of this ANN were extracted from varying signal received from experimental conditions such as the fluid pressure inside pipe, the shape and size of the leak area. Additional experiments were also carried out and with different objective which is to study the generation and characteristic of lamb and surface wave according to the pipe thickness

    14. A Study on the Leakage Characteristic Evaluation of High Temperature and Pressure Pipeline at Nuclear Power Plants Using the Acoustic Emission Technique

      International Nuclear Information System (INIS)

      Kim, Young Hoon; Kim, Jin Hyun; Song, Bong Min; Lee, Joon Hyun; Cho, Youn Ho

      2009-01-01

      An acoustic leak monitoring system(ALMS) using acoustic emission(AE) technique was applied for leakage detection of nuclear power plant's pipeline which is operated in high temperature and pressure condition. Since this system only monitors the existence of leak using the root mean square(RMS) value of raw signal from AE sensor, the difficulty occurs when the characteristics of leak size and shape need to be evaluated. In this study, dual monitoring system using AE sensor and accelerometer was introduced in order to solve this problem. In addition, artificial neural network(ANN) with Levenberg Marquardt(LM) training algorithm was also applied due to rapid training rate and gave the reliable classification performance. The input parameters of this ANN were extracted from varying signal received from experimental conditions such as the fluid pressure inside pipe, the shape and size of the leak area. Additional experiments were also carried out and with different objective which is to study the generation and characteristic of lamb and surface wave according to the pipe thickness

    15. Representation of deforestation impacts on climate, water, and nutrient cycles in the ACME earth system model

      Science.gov (United States)

      Cai, X.; Riley, W. J.; Zhu, Q.

      2017-12-01

      Deforestation causes a series of changes to the climate, water, and nutrient cycles. Employing a state-of-the-art earth system model—ACME (Accelerated Climate Modeling for Energy), we comprehensively investigate the impacts of deforestation on these processes. We first assess the performance of the ACME Land Model (ALM) in simulating runoff, evapotranspiration, albedo, and plant productivity at 42 FLUXNET sites. The single column mode of ACME is then used to examine climate effects (temperature cooling/warming) and responses of runoff, evapotranspiration, and nutrient fluxes to deforestation. This approach separates local effects of deforestation from global circulation effects. To better understand the deforestation effects in a global context, we use the coupled (atmosphere, land, and slab ocean) mode of ACME to demonstrate the impacts of deforestation on global climate, water, and nutrient fluxes. Preliminary results showed that the land component of ACME has advantages in simulating these processes and that local deforestation has potentially large impacts on runoff and atmospheric processes.

    16. KAJIAN ATAS FUNGSI SOSIAL PADA TINDAKAN EKONOMI PELAKU LEMBAGA KEUANGAN MIKRO SYARIAH

      Directory of Open Access Journals (Sweden)

      Awang Tri Satria

      2015-03-01

      Full Text Available This study aims to: 1 determine how actors in sharia microfinance institutions provide the perception toward the social function of the economic action undertaken. 2 determine the form of the social functions performed by the actors in sharia microfinance institutions. This study used a qualitative method with phenomenological approach. The findings of this study are: 1 the perception of the social function by the actors of sharia microfinance institutions respectively: a perception of social function is as management of zakat, infaq, and alms known in the concept of Baitul Maal. b the social function as a medium of empowerment of poor communities where the sharia microfinance institutions are capable in producing new entrepreneurs. c the social function as propaganda/symbols of Islam, Islamic microfinance institutions serve to eradicate the practice of existing usurer in the community. 2 The form of social functions held by sharia microfinance institutions are: a The distribution of social grants, the distribution of development aid in the form of mosques, procurement assistance of Al-Quran, home renovation, distribution of Zakat funds as well as scholarships to students who cannot afford school. b Help the poor public capital, capital assistance is intended for the poor, capital assistance is also easy for small traders in accessing financing. c Optimalization the role of sharia microfinance institutions by opening branches in remote areas which aim to facilitate the public in accessing Sharia financial institutions and also propaganda symbols of Islam in religious activities.

    17. Muslimah Entrepreneurship and Economic Empowerment in Pengajian

      Directory of Open Access Journals (Sweden)

      Ana Fadhilah

      2017-04-01

      Full Text Available It is a requirement in the practice of economic enterprising to gain productive skill training and capitalization or provision of capital using the moving loan for the member. However, there is still constraint for this method, which is some members are being late to return the loan, because of some reasons. This paper aims to analyze the effect of the moving loan for the pengajian (religious gathering of An Naml, especially who used it for the food processing business; and to analyze their income’s allocation, whether the income is allocated for the consumption, education, and health or set the income aside for the religious fund, such as infaq, alms, kurban and hajj’s fund. This paper employs qualitative and quantitative approaches, gathering data using in-depth interview, observation and distributing questioners to the 15 select members (purposive sampling. The analysis techniques used are descriptive analysis, paired t-test and correlation analysis. This paper found that the economic enterprise of the member of the An Naml religious gathering, according to the correlation test, proof that between the total income and the savings, before and after the loan given is positively related. In doing so, the connection between the total income and the religious fund before the loan given is related positively, but after the loan given the relation is undetected.

    18. VARLIK VERGİSİ VE MERSİN UYGULAMASI

      OpenAIRE

      ÇANAK, Erdem

      2016-01-01

      Türkiye, İkinci Dünya Savaşı’na girmemekle birlikte savaşın bütün sıkıntılarını yaşamıştır. Hatta bu sırada 1 milyona yakın vatandaşını da silâhaltına almıştır. Ülkenin çalışan ve üretim yapan nüfusunun silâhaltına alınması ise üretimde ciddi düşüşlere sebebiyet vermiştir. Bunun yanı sıra savaşın neden olduğu iktisadi sıkıntıların etkisiyle enflasyon yükselmiş, karaborsa ve vurgunculuk artmıştır. Bu durumdan en çok istifade edenler ise büyük toprak sahibi çiftçiler ile ticaretle iştigal eden ...

    19. Epidemiological trends and clinicopathological features of cutaneous melanoma in sporadic and xeroderma pigmentosum Tunisian patients.

      Science.gov (United States)

      Naouali, Chokri; Jones, Meriem; Nabouli, Imen; Jerbi, Manel; Tounsi, Haifa; Ben Rekaya, Mariem; Ben Ahmed, Melika; Bouhaouala, Balkiss; Messaoud, Olfa; Khaled, Aida; Zghal, Mohamed; Abdelhak, Sonia; Boubaker, Samir; Yacoub-Youssef, Houda

      2017-01-01

      Epidemiological features and trends of cutaneous melanoma (CM) in North-African populations remain unclear. Those populations are of particular interest as they belong to a mosaic of various other origins (sub-Saharan, European Ancestry, and North-African Berbers). The aim of this study is to draw epidemiological profile and clinicopathological features of CM in the Tunisian population. Incidence analyses were based on data from regional cancer registries. Clinical data were collected from dermatological departments and xeroderma pigmentosum (XP) referral centers and provided CM clinicopathological characteristics and progression. Statistical analyses were achieved using R packages and SPSS 20.0. The incidence of CM in Tunisia is relatively low (0.5-0.7 per 100,000 inhabitants per year). Gender differences were observed regarding anatomical distribution (P = 0.004). Acral lentiginous melanoma (ALM) was the most frequent histological subtype (32.3%); however, nodular melanoma (NM) was the most aggressive and responsible for 54.8% of deaths. CM in XP patients develops at a median age that is 42 years earlier than sporadic cases, with preferential localization on the head and neck (P Xeroderma pigmentosum stands as the major predisposing host factor. © 2016 The International Society of Dermatology.

    20. Cross-flow turbines: progress report on physical and numerical model studies at large laboratory scale

      Science.gov (United States)

      Wosnik, Martin; Bachant, Peter

      2016-11-01

      Cross-flow turbines show potential in marine hydrokinetic (MHK) applications. A research focus is on accurately predicting device performance and wake evolution to improve turbine array layouts for maximizing overall power output, i.e., minimizing wake interference, or taking advantage of constructive wake interaction. Experiments were carried with large laboratory-scale cross-flow turbines D O (1 m) using a turbine test bed in a large cross-section tow tank, designed to achieve sufficiently high Reynolds numbers for the results to be Reynolds number independent with respect to turbine performance and wake statistics, such that they can be reliably extrapolated to full scale and used for model validation. Several turbines of varying solidity were employed, including the UNH Reference Vertical Axis Turbine (RVAT) and a 1:6 scale model of the DOE-Sandia Reference Model 2 (RM2) turbine. To improve parameterization in array simulations, an actuator line model (ALM) was developed to provide a computationally feasible method for simulating full turbine arrays inside Navier-Stokes models. Results are presented for the simulation of performance and wake dynamics of cross-flow turbines and compared with experiments and body-fitted mesh, blade-resolving CFD. Supported by NSF-CBET Grant 1150797, Sandia National Laboratories.

    1. Ionic interactions in alkali-aluminium tetrafluoride clusters

      International Nuclear Information System (INIS)

      Akdeniz, Z.; Cicek, Z.; Karaman, A.; Pastore, G.; Tosi, M.P.

      1999-08-01

      Complex anion structures ((AlF 4 ) - , (AlF 5 ) 2- and (AlF 6 ) 3- ) coexist in liquid mixtures of aluminium trifluoride and alkali fluorides in composition-dependent relative concentrations and are known to interact with the alkali counterions. We present a comparative study of the static and vibrational structures of MAlF 4 molecules (with M = any alkali), with the aim of developing and testing a refined model of the ionic interactions for applications to the Al-M fluoride mixtures. We find that, whereas an edge-bridged coordination is strongly favoured for Li in LiAIF 4 , edge-bridging and face-bridging of the alkali ion become energetically equivalent as one moves from Na to the heavier alkalis. This result is sensitive to the inclusion of alkali polarizability and may be interpreted as implying (for M = K, Rb or Cs) almost free relative rotations of the M + and (AlF 4 ) - partners at temperatures of relevance to experiment. The consistency of such a viewpoint with electron diffraction data on vapours and with Raman spectra on melts is discussed. (author)

    2. US nuclear cleanup shows signs of progress

      International Nuclear Information System (INIS)

      Renner, R.

      1997-01-01

      The U.S. Department of Energy's program for dealing with the radioactive and hazardous wastes at its former nuclear weapons production sites and at the national laboratories has been criticized for its expense and slow pace of cleanup. The largest environmental restoration and waste management program in the world faces formidable technical and scientific problems and these, according to numerous investigative committees and commissions, have been compounded by poor management, misuse of technology, and failure to appreciate the need for new basic scientific knowledge to solve many of the cleanup problems. In the past three years, DOE's Office of Environmental Management (EM), often spurred by congressional action, has begun to trim costs and accomplish more. New measures have been introduced to improve contract efficiency, better utilize existing remediation technologies, renegotiate compliance agreements, and begin basic research. Environmental Management Assistant Undersecretary Alvin Alm, appointed in May 1996, is seeking to solidify these changes into an ambitious plan to clean up most of DOE's 130 sites by 2006. But there are widespread doubts that EM has the money, skill, and will to turn itself around. There are also concerns that, in the name of efficiency and economy, EM may be negotiating lower cleanup standards and postponing some difficult cleanup tasks. This article discusses these issues. 7 refs

    3. Strategic Model Of Poverty Reduction Through The Law As A Tool Of Social Engineering

      Directory of Open Access Journals (Sweden)

      Burhanudin

      2015-04-01

      Full Text Available Abstract This study aims to gain a deep understanding and overview of the management of zakat to reduce poverty and to analyze the implementation of the Agency in various charity and the National Zakat Institutions established by the community. The results showed that the charity is required to optimize the collection of high professionalism through several strategies give alms to the muzakki understanding encourage mustahik for always trying to make himself into a muzakki. Zakat has dimensions of economic and social functions or equity gift of God and is also a manifestation of social solidarity statement of humanity and justice. Law can be used as a means of overcoming the problem of poverty the effort should be made to the coordination consolidation and better cooperation in other fields. In the end it is said that the handling of the problem of poverty should be done in a holistic manner. Empowerment of zakat in Indonesia needs a credible zakat institutions and high transparency so that people who pay their zakat has confidence in these institutions. The new strategy is built is a triangular pattern and square pattern synergy synergy umaro institutions and regulatory and scholars to cultivate together in the collection management and distribution of zakat.

    4. The blueschits from the Kopina Mt., West Sudetes, Poland - what do they tell us about accretion of the Variscides?

      Science.gov (United States)

      Majka, Jarosław; Mazur, Stanisław; Kośmińska, Karolina; Dudek, Krzysztof

      2015-04-01

      Blueschists are tracers of sutures, thus marking fossil subduction zones at convergent plate boundaries and providing important constraints on plate tectonic reconstructions. Their occurrences are scarce in the Variscan belt owing to a strong collisional overprint but just because of that each locality deserves particular attention. The Variscan blueschists must have formed during the early stage of the Variscan Orogeny and may represent a vestige of missing marginal basins fringing the Rheic Ocean at the onset of subduction. The studied rocks from the Kopina Mt. consist mainly of garnet, glaucophane, clinozoisite-epidote, chlorite-I, titanite, hematite and quartz. The original high-pressure assemblage is overprinted by later, lower pressure paragenesis, which comprises mostly Ca-amphiboles, chlorite-II, albite and K-feldspar. The latter occurs in polymineral inclusions in other phases together with albite and chlorite that are interpreted as phengite breakdown products. Garnet shows chemical compositional variation from Alm54Prp3Grs30Sps13 in the cores to Alm66Prp4Grs29Sps1 in the rims. The almandine zoning is bowl-shaped, whereas spessartine profiles show bell-shaped trends. The grossular and pyrope contents are generally constant throughout the grain. Rather gradual changes in the chemical zoning suggest a progressive, one-step garnet growth pattern. Glaucophane, although commonly well preserved, in some cases disintegrates to the albite-chlorite assemblage. The pressure-temperature (P-T) conditions were estimated using the phase equilibrium modelling in the NCKFMMnASHTO system using the PerpleX software. The compositional isopleths cross cut in the stability field of Grt+Gln+Ep+Chl+Pheng+Ttn+Hem+Q. P-T estimates indicate that the peak conditions occur at c. 14-17 kbar and 470-500°C, which corresponds to quite a low geothermal gradient in the range of 8-10°C/km. The P-T conditions estimated lie on a low temperature geotherm that is typical for a relatively

    5. Interaction of extended mantle plume head with ancient lithosphere: evidence from deep-seated xenoliths in basalts and lamprophyre diatremes in Western Syria

      Science.gov (United States)

      Sharkov, Evgenii

      2016-04-01

      The Middle Cretaceous lamprophyric diatremes of the Jabel Ansaria Ridge contain xenoliths of ancient lower crustal rocks mainly represented by the suite of partly altered garnet granulite and eclogite-like rocks, which were formed at the expense of ferrogabbros and ferroclinopyroxenites most likely in the course of underplating of Fe-Ti basalt. Garnet (Alm26Grs11Py63) megacrysts and coarse-granular garnet-clinopyroxene intergrowths are most likely the varieties of rocks of this series. Garnet megacrysts are represented by large (up to 10 cm in diameter) round "nodules," often molten from the surface. Garnet is usually fractured, and the kelyphite material similar to that in rocks of the eclogite-granulite series occurs in fractures. In addition, we found several intergrowths of garnet with large (up to 3-5 cm in length) crystals of high-Al augite with the low of Ti and Na contents like in rocks of the eclogite-granulite suite. Coarse-grained garnet-clinopyroxene-hornblende rocks with spinel, as well as megacrysts of Al-Ti augite with kaersutite, form the second group in prevalence. This group is close to mantle xenoliths of the "black series" in alkali Fe-Ti basalt worldwide. Kaersutite in these rocks contains gaseous cavities, which provides evidence for the origin of rocks at the expense of a strongly fluidized melt/fluid. In contrast to rocks of the eclogite-granulite series, these rocks did not undergo alteration. Garnet Alm19-26Grs12-13.5Py59-67.5 usually associates with dark opaque spinel. In contrast, the Late Cenozoic plateaubasalts of the region practically do not contain lower crustal xenoliths, whereas xenoliths of mantle spinel lherzolite (fragments of the upper cooled rim of the plume head) are widely abundant. According to data of mineralogical thermobarometry, rocks of the eclogite-granulite suite were formed at 13.5-15.4 kbar (depths of 45-54 km) and 965-1115°C. Rocks of this suite are typical representatives of the continental lower crust

    6. Analytical equations for CT dose profiles derived using a scatter kernel of Monte Carlo parentage with broad applicability to CT dosimetry problems

      International Nuclear Information System (INIS)

      Dixon, Robert L.; Boone, John M.

      2011-01-01

      Purpose: Knowledge of the complete axial dose profile f(z), including its long scatter tails, provides the most complete (and flexible) description of the accumulated dose in CT scanning. The CTDI paradigm (including CTDI vol ) requires shift-invariance along z (identical dose profiles spaced at equal intervals), and is therefore inapplicable to many of the new and complex shift-variant scan protocols, e.g., high dose perfusion studies using variable (or zero) pitch. In this work, a convolution-based beam model developed by Dixon et al.[Med. Phys. 32, 3712-3728, (2005)] updated with a scatter LSF kernel (or DSF) derived from a Monte Carlo simulation by Boone [Med. Phys. 36, 4547-4554 (2009)] is used to create an analytical equation for the axial dose profile f(z) in a cylindrical phantom. Using f(z), equations are derived which provide the analytical description of conventional (axial and helical) dose, demonstrating its physical underpinnings; and likewise for the peak axial dose f(0) appropriate to stationary phantom cone beam CT, (SCBCT). The methodology can also be applied to dose calculations in shift-variant scan protocols. This paper is an extension of our recent work Dixon and Boone [Med. Phys. 37, 2703-2718 (2010)], which dealt only with the properties of the peak dose f(0), its relationship to CTDI, and its appropriateness to SCBCT. Methods: The experimental beam profile data f(z) of Mori et al.[Med. Phys. 32, 1061-1069 (2005)] from a 256 channel prototype cone beam scanner for beam widths (apertures) ranging from a = 28 to 138 mm are used to corroborate the theoretical axial profiles in a 32 cm PMMA body phantom. Results: The theoretical functions f(z) closely-matched the central axis experimental profile data 11 for all apertures (a = 28 -138 mm). Integration of f(z) likewise yields analytical equations for all the (CTDI-based) dosimetric quantities of conventional CT (including CTDI L itself) in addition to the peak dose f(0) relevant to SCBCT

    7. Tüketimin Değişen Yüzü: Elektronik Ticaret Uygulamaları ve Sosyal Paylaşım Ağlarının Rolü / The Changing Face of Consumption: E-Commerce Applications And The Role of Social Networks

      Directory of Open Access Journals (Sweden)

      Büşra Halis

      2012-12-01

      Full Text Available İnsanlık tarihi kadar eski olan tüketim, zaman içerisinde yaşanan değişim ve dönüşümlerle birlikte yeni bir boyut kazanmıştır. Eskinin, ihtiyacı kadar almak ve çalışmak gibi fenemonlerinin yerini, günümüzde daha çok satın almak için çalışmak, tükettiğinin ölçüsünde var olabilmek ya da olamamak almıştır. Tüketimin soyut anlamda kavramsal içeriğinin farklılaşmasının yanı sıra, tüketim araçları da farklılaşmıştır. Artık, yüz yüze görüşmeler yoluyla yapılan alışverişlerin yerini; fiziki mekândan bağımsız, internet üzerinden e-ticaret yoluyla ve birtakım paylaşım ağları aracılığıyla yapılan alışverişler almıştır. Bu çalışmada da, tüketimin ve tüketimde kullanılan araçların geçmişten bugüne değişen anlamı ve bu değişimi körükleyen sosyal ağ paradigması tartışılmaktadır. The Changing Face of Consumption: E-Commerce Applications And The Role of Social Networks Consumption, which is as old as human history has gained a new dimension with changes and transformations in the course of time. In the past, people bought and worked as they needed, but now, they work to buy more things except necessity and they be or not to be until they consumed. Over time, the conceptual content and tools of the consumption has changed. Shopping, which is done independent of the physical space, via the internet through e-commerce replaced shopping made by face to face. In this work, the changing meaning and tools of consumption from past to present and the paradigm of social networks which encouraging this change is to be held.

    8. Fonksiyonel Özellikleri Geliştirilmiş Yoğurt Üretimi

      Directory of Open Access Journals (Sweden)

      Özge Duygu Okur

      2015-02-01

      Full Text Available Bu çalışmada, farklı inkübasyon sıcaklık (25 ºC ve 42 ºC ve kefir destek kültürü kullanımının, yoğurtların mikrobiyolojik, fizikokimyasal ve duyusal özellikleri üzerine etkisi araştırılmıştır. Tam yağlı yoğurt örneklerinin yanı sıra, yağ ikamesi ve prebiyotik özelliği olan inulin yağsız yoğurt üretiminde kullanılmıştır. Mikrobiyolojik değerlendirmeler sonucunda özellikle Lactobacillus içerikleri, farklı kültür ve inkübasyon sıcaklık kombinasyonlarından önemli derecede etkilenmiştir. Kefir destek kültürü kullanılan yoğurtlarda mayalar da gelişmiştir. Duyusal analiz değerlendirmeleri sonucunda ise, en fazla puan alan ürün inulin ilaveli yoğurt kültürü ile yapılan yağsız yoğurt olurken, ikinci sırayı yine inulin ilaveli, kefir ve yoğurt kültürünün birlikte kullanıldığı ve 420C'de inkübe edilen yağsız yoğurt örneği almıştır. En düşük genel skoru, sadece kefir kültürü kullanılıp 420C'de inkübe edilen örnek almıştır. Kefir destek kültürü ile üretilen örneklerde CO2 oluşumundan dolayı orta büyüklükte gözenekler (yaklaşık 0.5 cm çaplı tespit edilmiştir. Duyusal analiz sonuçlarına göre ürünlerde kefir kültür kullanımı yabancı tat üzerine önemli düzeyde etkili olmuştur.

    9. İnsana Verilen Değer Ekseninde Çeşitli Dinlerde İnsan: Dinler Tarihi Açısından Karşılaştırmalı Bir Araştırma

      Directory of Open Access Journals (Sweden)

      Şevket Özcan

      2016-06-01

      Full Text Available İlk insandan itibaren insanoğlu, evrenin ve hayatın merkezinde yer almıştır.İnsanın sahip olduğu özelliklerden ve tarih boyunca içinde bulunduğu durumlardanbahseden kaynaklar mevcuttur. Bu kaynaklardan birisi olan din, insan hayatındaçok önemli bir yere sahiptir çünkü insan, varoluş nedeni ve amacının cevabını dindebulmuştur. İnsanlık tarihi kadar eski ve köklü geçmişi olan ve tarihi değeri bulunanbütün dinlerin mesajlarında insana üstün bir değer verilmektedir. Nitekim bu dinlerde,bu değerin göstergesi olarak günümüzde de büyük önem atfedilen temel insan haklarınınköklerini bulmak mümkündür. Çünkü bütün dinler, insanın hem dünyada hemde ölümden sonra mutluluğa ulaşmasını hedefl emekte ve bunu temel kaynaklarındaaçıkça ifade etmektedir. Bu amaç doğrultusunda dinler, insanın canını, aklını, malını,namusunu ve dinini koruma altına almış ve bunları korumayı temel esasları halinegetirmişlerdir. Bu nedenle insanların tarih boyunca elde etmek için çabaladıkları temelhaklar, dinlerin koruma altına aldığı beş temel esas olarak özetlenebilir. Böyleliklesöz konusu beş temel esas üzerine temellendirilen temel hakların günümüzde İnsanHakları Evrensel Beyannamesi’nde belirtilen haklar haline geldiği ifade edilebilir.Bu durumda dinler, insana verdikleri değer ekseninde insani birtakım gayretlerle eldeedilmeye çalışılan temel hakların garantörü olarak kabul edilebilir. Bu makalede, Yahudilik,Hıristiyanlık ve İslam dışında Hint, Çin, Japon ve Eski İran dinleri ile Sabiilikgibi bazı dinlerin insana bakışının ve insana verdikleri değerin genel bir çerçevesiçizilmeye gayret edilmektedir.

    10. II. Abdülhamit İstanbul’unda Yabancı Okullara Genel Bakış / General Overview of Foreign Schools in Istanbul during Sultan Abdulhamit II

      Directory of Open Access Journals (Sweden)

      Zeki Tekin

      2017-06-01

      Full Text Available Abstract The presence of foreign schools in Ottoman lands goes back to the classical periods of the Ottoman Empire. Foreign schools, whose presence was not given importance and formed solely for the needs of the foreign people, ultimately took an important and dangerous situation as the Ottoman Empire evolved into various political stages as time passed. During and after the Tanzimat Reforms, after which the power balance changed against the Ottoman Empire, the fact that missionary activities increased in the religious, cultural and educational fields for the non-Muslim people increased the polarizations and started a wave of separatism among the non-Muslim public. Foreseeing the danger Abdulhamit II took urgent and rapid precautions, making progresses in education all over the empire primarily in Istanbul. However, these efforts were not sufficient and the foreign schools established by the missionaries continued dangerous political and social activities both in quality and effect. We wanted to take attention to the consequences of these foreign schools which took an important part in the fate of a nation. Öz Yabancı okulların Osmanlı topraklarındaki mevcudiyeti Osmanlı’nın klasik dönemlerine kadar gitmektedir. İlk evrelerinde varlığı pek önemsenmeyen ve tamamen yabancı teba için bir ihtiyaç olarak ortaya çıkan yabancı okullar, ilerleyen süreçler içerisinde Osmanlı Devleti’nin geldiği siyasal seviyeye bağlı olarak fevkalade önemli ve tehlikeli bir hal almıştı. Güç dengelerinin Osmanlı aleyhine geliştiği Tanzimat ve sonrası dönemlerde gayr-i müslim tebaya dönük dini, kültürel ve eğitim alanlarında misyonerlik faaliyetlerinin yoğunlaşması toplumsal kutuplaşmaları artırmış ve gayr-ı müslim topluluklar üzerinde ayrılıkçı rüzgarlar estirmiştir. Tehlikenin büyüklüğünü gören II. Abdülhamit acil ve seri tedbirler almış başta İstanbul olmak üzere imparatorluğun her yerinde e

    11. Türkiye’de Yaygın Gelişimsel Bozukluklar Alanında Gerçekleştirilen Lisansüstü Tez Çalışmalarının Gözden Geçirilmesi

      Directory of Open Access Journals (Sweden)

      Özge Eliçin

      2011-07-01

      Full Text Available Bu araştırmada, Türkiye’de yaygın gelişimsel bozukluklar alanında 1990-2011 yılları arasında lisansüstü düzeyde gerçekleştirilen tez çalışmalarının gözden geçirilmesi amaçlanmıştır. Bu araştırma için kaynaklara Yüksek Öğretim Kurulu’nun internet sitesinden ulaşılmıştır. Taramada anahtar kelime olarak “otizm”, “otistik bozukluk”, “otizm spektrum bozukluğu/yaygın gelişimsel bozukluk”, “Asperger” kelimeleri kullanılmıştır. Bunun yanında Zihinsel Yetersizlik ve Gelişimsel Bozukluk Alanlarında Lisansüstü Tez Bibliyografyası (Diken, Ünlü ve Karaaslan, 2008 kitabından “otizm”, “otistik bozukluk” ve “yaygın gelişimsel bozukluk”, “Asperger” kelimelerini içeren tezler araştırmaya dâhil edilmiştir. Araştırmaya dâhil edilen tezlerde a yaygın gelişimsel bozukluklar alanından bir tanı almış çocuklarla ya da bu tanı kriterlerine sahip çocukların aileleriyle yürütülmüş olması b incelenen durumların (görüş, olgu, karşılaştırma, etki yaygın gelişimsel bozukluklar alanından bir tanı almış çocuklar için yapılmış olması c çalışmaların yüksek lisans ve doktora tezi olması özellikleri aranmıştır. Araştırmada bu amaçla gerçekleştirilen toplam 79 teze ulaşılmıştır. Tezlerin analizi aşamasında, tezler konularına göre 6 kategoriye ayrılmıştır. Her bir kategoride yer alan tezler karşılaştırmalı olarak incelenmiştir. The purpose of this study is to review graduate studies (master thesis and doctoral dissertations regarding pervasive developmental disorders (PDD carried out between 1990-2011 in Turkey. Graduate studies were reached through website of Higher Education Council of Turkey by using keywords of “autism, autistic disorder, and pervasive developmental disorder/autism spectrum disorders”. In addition, graduate studies listed in the book (Diken, Ünlü and Karaaslan, 2008 entitled “Bibliography of

    12. DEL GESTO ARTÍSTICO A LA PRODUCCIÓN DE ESPACIO PÚBLICO: CREACIÓN Y ACCIÓN EN LA CIUDAD VIVIDA / From the artistic gesture to the production of public space: creation and action in the living city

      Directory of Open Access Journals (Sweden)

      Marta Serra Permanyer

      2010-05-01

      Full Text Available RESUMEN Del gesto artístico a la producción de espacio público: creación y acción en la ciudad vivida explora las formas de intervención en el espacio público que relacionan el arte con la transformación de las ciudades contemporáneas, y que tiene como principal objetivo dar a conocer un nuevo género de prácticas espaciales creativas que, de forma crítica y colaborativa, son generadas desde el campo del arte y destinadas a la construcción social del paisaje urbano. Enmarcándose en la investigación de un proyecto de tesis, se pretende traspasar las fronteras de la disciplina del urbanismo y la arquitectura más ortodoxas para abrirlas a otras miradas y modos de hacer que descubren en la práctica artística en medio urbano su potencial transformador dentro del ámbito político y social. A través del trabajo de tres artistas europeas se deconstruye la idea tradicional de arte publico, un binomio contaminado y en cierto modo decadente. Loraine Leeson, Marjetica Potrč y Lara Almárcegui, entre muchas otras, se presentan aquí como herederas de unos años setenta que dejaron paso a un nuevo género artístico que insinuaba la disolución del arte en la experiencia más cercana y popular. Ejemplos pasados y recientes fijarán las particularidades y condiciones del espacio público contemporáneo desvelando, a su vez, carencias y oportunidades sobre las formas de sociabilizarnos y hacer ciudad, construyendo en su conjunto, una crítica a nuestro entorno cotidiano. SUMMARY From the artistic gesture to the production of public space: creation and action in the living city explores the forms of intervention in the public space that relate art to the transformation of contemporary cities. The articles main objective is that of presenting a new genre of creative space practices which, in a critical and collaborative manner, are generated from the field of art and destined for the social construction of the urban landscape. Framed within

    13. Análise biomecânica dos efeitos da crioterapia no tratamento da lesão muscular aguda Biomechanical analysis of the cryotherapy effects in the treatment of acute muscular injury

      Directory of Open Access Journals (Sweden)

      João Paulo Chieregato Matheus

      2008-08-01

      Full Text Available A crioterapia é amplamente utilizada por atletas profissionais e amadores no tratamento agudo de lesões musculares. Este trabalho teve como objetivo analisar as propriedades mecânicas do músculo gastrocnêmio lesionado por impacto direto e tratado com crioterapia. Para tanto, foram utilizadas 24 ratas Wistar, divididas em três grupos experimentais: grupo controle (C: animais mantidos em gaiolas-padrão por seis dias; grupo lesionado (L: animais submetidos à lesão por mecanismo de impacto no gastrocnêmio, sem tratamento e mantidos em gaiolas-padrão por seis dias; grupo lesionado e tratado com crioterapia (LC: animais submetidos à lesão, tratados com uma sessão de crioterapia, imediatamente após a lesão e mantidos em gaiolas-padrão por seis dias. Após essas etapas, os animais foram submetidos à eutanásia para que fossem realizados os ensaios mecânicos de tração dos músculos gastrocnêmios direitos, na máquina universal de ensaios (EMIC®. A partir dos gráficos carga versus alongamento de cada ensaio, foram calculadas as seguintes propriedades mecânicas: carga no limite máximo (CLM, alongamento no limite máximo (ALM e rigidez (R. No ALM, o grupo C apresentou diferença estatística (p Cryotherapy is widespread used in the acute treatment of muscle injuries of professional and unprofessional athletes. The purpose of this study was the investigation of mechanical properties of gastrocnemius muscle submitted to a impact mechanism of injury and treated with cryoterapy. Therefore, twenty four female Wistar rats were divided into three groups: Control (C: animals housed in standard cages for six days; Lesion (L: animals submitted to a direct impact mechanism of injury in the gastrocnemius muscle, without any treatment and kept into standard cages during six days; Lesion e cryotherapy (LC: animals submitted to the contusion, treated with a single session of cryotherapy immediately after lesion and housed in standard cages during

    14. BANDINI LEÃO DE SOUSA, M.ª do Socorro. «Internet bajo la óptica de la historia vista desde abajo: una telaraña de significaciones en pequeños grandes discursos». Salamanca: Universidad de Salamanca, 2011 (Tesis doctoral dirigida por el Dr. Joaquín García

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      M.ª do Socorro BANDINI LEÃO DE SOUSA

      2012-02-01

      Full Text Available Esta tesis, del Curso Procesos de Formación en Espacios Virtuales, de la Facultad de Educación, del Departamento de Teoría e Historia de la Educación, de la Universidad de Salamanca, bajo orientación del Prof. Dr. Joaquín García Carrasco, se ubica en el área de los estudios sobre las Nuevas Tecnologías de Información y Comunicación – TIC y se delimita al tema sobre la importancia de la Internet en sitios de exclusión social, el pueblo de Almécegas, en el Estado de Ceará, Brasil, donde esa tecnología llegó antes que la luz eléctrica, por medio de la energía solar. Damos por sentado que los discursos respecto la valoración de la Internet se fundamentan en los documentos escritos, oficiales, es decir, en la historia vista desde arriba, paradigma tradicional de la Historia. Por hipótesis, presentamos la historia vista desde abajo, nuevo paradigma de la Historia, constituida por los discursos orales de personas sencillas y anónimas de ese pueblo, para fundamentar la valoración de la Internet. Esta tesis se fundamenta en un planteamiento inter y transdisciplinar para decir que la Internet es un mundo de contrarios, para bien y para mal, puesto que la sociedad también lo es. Tal planteamiento camina por una investigación cualitativa que, por medio de una mirada etnográfica, realiza una observación participante, con base en Bronislaw Malinowski y en el paradigma indiciario, morelliano (In: Ginzburg, 2009, es decir, la observación de los detalles, aparentemente sin importancia y, sin embargo, reveladores de significados. En cuanto al carácter general, objetivamos contribuir con los estudios sobre la importancia de la Internet. En cuanto a la especificidad, establecimos los siguientes objetivos: 1. examinar el significado de importancia de la Internet en los discursos de la historia vista desde abajo. 2. examinar el significado de importancia de la Internet en los discursos de la historia vista desde arriba. 3. Verificar la

    15. Alteração do arco longitudinal medial na neuropatia periférica diabética Medial longitudinal arch change in diabetic peripheral neuropathy

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      Isabel de Camargo Neves Sacco

      2009-01-01

      Full Text Available OBJETIVO: Descrever e comparar as características antropométricas dos pés de sujeitos saudáveis e diabéticos neuropatas por meio de índices classificatórios do Arco Longitudinal Medial (ALM: Índice do Arco (IA, Índice de Chippaux-Cmirak (CSI e Ângulo  ( e comparar a classificação destes métodos nestes grupos. MATERIAIS E MÉTODO: Grupo controle (GC composto por 21 sujeitos saudáveis, e grupo diabético (GD, formado por 46 diabéticos portadores de neuropatia diabética. Pela impressão plantar foram calculados os índices. RESULTADOS: Houve maior proporção de pés planos no GD para os três índices (IA: 32,2%, CSI: 59,7%, A: 17,5%, enquanto os pés cavos comportaram-se de forma contrária. Os grupos foram estatisticamente diferentes em relação à proporção de pés planos no IA (p=0,0080 e no CSI (p=0,0000 e de pés cavos no  (p=0,0036. Houve diferença significativa quando comparados GC e GD para os três índices: IA (p=0,0027, CSI (p=0,0064,  (p=0,0296. CONCLUSÃO: Os dados demonstram alterações motoras e ortopédicas decorrentes da neuropatia periférica, responsável pela desestruturação do pé, levando ao desabamento do ALM. Observou-se que o ângulo A destoou fortemente da classificação do arco feita pelos outros dois índices, e com isso destacamos que sua utilização merece cuidado.OBJECTIVE: To describe and compare foot anthropometry in healthy and diabetic subjects using Medial Longitudinal Arch (MLA classificatory indexes: Arch Index (AI, Chippaux-Smirak Index (CSI and  Angle (Â, as well as to compare the classification of these methods in each group. MATERIALS AND METHODS: Control Group (CG composed by 21 healthy subjects and Diabetic Group (DG, with 46 diabetic neuropathy subjects. The indexes were calculated from footprints. RESULTS: A larger proportion of flat feet was seen in DG for the three indexes (AI: 32,2%, CSI: 59,7%, A: 17,5%, while highly arched feet acted oppositely. The groups were

    16. Análise de cointegração e geração de cenários na alocação de investimentos em previdência complementar [doi: 10.5329/RECADM.2013023

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      Wesley Vieira Silva

      2013-12-01

      Full Text Available ANÁLISE DE COINTEGRAÇÃO E GERAÇÃO DE CENÁRIOS NA ALOCAÇÃO DE INVESTIMENTOS EM PREVIDÊNCIA COMPLEMENTAR   RESUMO O objetivo desse trabalho é apresentar uma aplicação por meio da modelagem de alocação de carteiras de investimentos analisando as relações de longo prazo entre os ativos financeiros e indicadores econômicos, por meio da técnica de cointegração. Os dados observados são séries temporais de indicadores econômicos e do mercado financeiro, compreendendo o período de implantação do plano Real. Os resultados obtidos auxiliam na compreensão da estrutura de decisão de uma Entidade Fechada de previdência complementar, gerando informações sobre as relações de longo prazo das variáveis que servem como subsídio para a geração de cenários probabilísticos. As diversas táticas de investimentos são avaliadas quanto ao seu desempenho ao longo de 40 anos de projeção. A validação dos resultados é realizada pautando-se no pacote estatístico S-Plus, permitindo um aprofundamento sobre a estratégia a ser adotada, levando-se em consideração a necessidade de gestão dos riscos, em específico aqueles associados à manutenção da solvência do plano de previdência.   Palavras-chave Asset Liability Management (ALM; Fundos de Pensão; Cointegração.     GENERATION OF SCENARIOS AND COINTEGRATION ANALYSIS FOR ALLOCATION INVESTMENT IN SUPPLEMENTARY PENSION FUND   ABSTRACT The objective of this work is to present for an investment portfolio allocation taking into consideration long-term relations between financial assets and economy indexes. The observed data are from a time series of economic indicators, as well the financial market, encompassing the period of the Real Plan establishment. The gathered results assist in the understanding of decision structures from a Closed Pension Fund, generating information on the relations of long-term period from variables which can be used as parameters for probabilistic

    17. Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system.

      Science.gov (United States)

      Toth, Marton Lorant; Melentijevic, Ilija; Shah, Leena; Bhatia, Aatish; Lu, Kevin; Talwar, Amish; Naji, Haaris; Ibanez-Ventoso, Carolina; Ghose, Piya; Jevince, Angela; Xue, Jian; Herndon, Laura A; Bhanot, Gyan; Rongo, Chris; Hall, David H; Driscoll, Monica

      2012-06-27

      Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite restructuring and loss of synaptic integrity are hypothesized to contribute to human brain decline and dysfunction, we combined fluorescence microscopy and electron microscopy (EM) to screen at high resolution for nervous system changes. We report two major components of morphological change in the aging C. elegans nervous system: (1) accumulation of novel outgrowths from specific neurons, and (2) physical decline in synaptic integrity. Novel outgrowth phenotypes, including branching from the main dendrite or new growth from somata, appear at a high frequency in some aging neurons, but not all. Mitochondria are often associated with age-associated branch sites. Lowered insulin signaling confers some maintenance of ALM and PLM neuron structural integrity into old age, and both DAF-16/FOXO and heat shock factor transcription factor HSF-1 exert neuroprotective functions. hsf-1 can act cell autonomously in this capacity. EM evaluation in synapse-rich regions reveals a striking decline in synaptic vesicle numbers and a diminution of presynaptic density size. Interestingly, old animals that maintain locomotory prowess exhibit less synaptic decline than same-age decrepit animals, suggesting that synaptic integrity correlates with locomotory healthspan. Our data reveal similarities between the aging C. elegans nervous system and mammalian brain, suggesting conserved neuronal responses to age. Dissection of neuronal aging mechanisms in C. elegans may thus influence the development of brain healthspan-extending therapies.

    18. On the microstructure analysis of FSW joints of aluminium components made via direct metal laser sintering

      Science.gov (United States)

      Scherillo, Fabio; Astarita, Antonello; di Martino, Daniela; Contaldi, Vincenzo; di Matteo, Luca; di Petta, Paolo; Casarin, Renzo; Squillace, Antonino; Langella, Antonio

      2017-10-01

      Additive Manufacturing (AM), applied to metal industry, is a family of processes that allow complex shape components to be realized from raw materials in the form of powders. The compaction of the powders can be achieved by local melting of the powder bed or by solid state sintering. Direct Metal Laser Sintering (DMLS) is an additive manufacturing process in which a focalized laser beam is the heat source that allows the powders to be compacted. By DMLS it is possible to realize complex shape components. One of the limits of DMLS, as for every additive layer manufacturing techniques, is the unfeasibility to realize large dimension parts. Due to this limit the study of joining process of parts made via ALM is of great interest. One of the most promising options is the Friction Stir Welding (FSW), a solid state welding technique that has been proven to be very effective in the welding of metals difficult to weld, above all aluminium alloys. Since FSW is a solid-state technique, the microstructure of the various zone of the weld bead depends not only by the process itself but also by the parent microstruct ure of the parts to be welded. Furthermore, parts made of aluminium alloy via DMLS have a particular microstructure that is the result of repeated severe thermal cycles. In the present work the authors, starting from the description of the parent microstructure of parts made of AlSi10Mg aluminium alloy, study the microstructure evolution occurred within the joint made by Friction Stir Welding, analysing in details the microstructure of the main well recognized zone of the weld bead. The structure of the parent material is characterized by the presence of melting pools with a very fine microstructure. In the joint the recrystallization, the grain refinement and, above all, the redistribution of intermetallic phases occurs, resulting in an homogenization of the microstructure and in an increase of micro hardness.

    19. Hasan Basri Çantay’ın “On Kere Kırk Hadis” Adlı Eserinde Ahkâm Hadislerine Getirdiği Fıkhî Yorumlar

      Directory of Open Access Journals (Sweden)

      Mehmet Özkan

      2015-06-01

      Full Text Available Milli mücadele yıllarının öne çıkan isimlerinden biri olan Hasan Basri Çantay yazarlık, gazetecilik, öğretmenlik ve milletvekilliği gibi birçok alanda faaliyet göstermiş, çeşitli konularda yazılar yazmış, eserler kaleme almıştır. İslami ilimler alanında da kendini yetiştiren Çantay’ın bu alandaki en önemli eseri “Kur’an-ı Hakîm ve Meal-i Kerîm” adlı Kur’an mealidir. İkinci önemli eseri, “On Kere Kırk Hadis” adlı kitabıdır. 1955-1962 yılları arasında üç cilt halinde basılan bu kitap iman, ibâdet, temizlik, ahlak, muâmelat, evlenme, boşanma, suç ve cezalar, şûra, askerlik ve cihat, savaş hukuku,  helal,  haram gibi birçok konuyla ilgili bin iki yüz hadisten oluşmaktadır. Bunların yaklaşık dört yüz yirmisi ahkâm hadisidir. Çantay, hadisleri tercüme etmekle kalmamış yeri geldikçe izahlarda da bulunmuştur. Bu çalışmada Çantay’ın yaklaşık yüz otuz ahkâm hadisine yaptığı izah ve fıkhî değerlendirmelerden örneklere yer verilecektir.

    20. Exploring the relationships between epistemic beliefs about medicine and approaches to learning medicine: a structural equation modeling analysis.

      Science.gov (United States)

      Chiu, Yen-Lin; Liang, Jyh-Chong; Hou, Cheng-Yen; Tsai, Chin-Chung

      2016-07-18

      Students' epistemic beliefs may vary in different domains; therefore, it may be beneficial for medical educators to better understand medical students' epistemic beliefs regarding medicine. Understanding how medical students are aware of medical knowledge and how they learn medicine is a critical issue of medical education. The main purposes of this study were to investigate medical students' epistemic beliefs relating to medical knowledge, and to examine their relationships with students' approaches to learning medicine. A total of 340 undergraduate medical students from 9 medical colleges in Taiwan were surveyed with the Medical-Specific Epistemic Beliefs (MSEB) questionnaire (i.e., multi-source, uncertainty, development, justification) and the Approach to Learning Medicine (ALM) questionnaire (i.e., surface motive, surface strategy, deep motive, and deep strategy). By employing the structural equation modeling technique, the confirmatory factor analysis and path analysis were conducted to validate the questionnaires and explore the structural relations between these two constructs. It was indicated that medical students with multi-source beliefs who were suspicious of medical knowledge transmitted from authorities were less likely to possess a surface motive and deep strategies. Students with beliefs regarding uncertain medical knowledge tended to utilize flexible approaches, that is, they were inclined to possess a surface motive but adopt deep strategies. Students with beliefs relating to justifying medical knowledge were more likely to have mixed motives (both surface and deep motives) and mixed strategies (both surface and deep strategies). However, epistemic beliefs regarding development did not have significant relations with approaches to learning. Unexpectedly, it was found that medical students with sophisticated epistemic beliefs (e.g., suspecting knowledge from medical experts) did not necessarily engage in deep approaches to learning medicine

    1. Blueschist metamorphism and its tectonic implication of Late Paleozoic-Early Mesozoic metabasites in the mélange zones, central Inner Mongolia, China

      Science.gov (United States)

      Zhang, Jinrui; Wei, Chunjing; Chu, Hang

      2015-01-01

      Blueschists in central Inner Mongolia are distributed as layers and blocks in mélanges including the southern zone in Ondor Sum area and the northern zone in Manghete and Naomuhunni areas. They have been attributed to the subduction of Early Paleozoic oceanic crust. Blueschists from Ondor Sum and Naomuhunni are characterized by occurrence of sodic amphibole coexisting with epidote, albite, chlorite, calcic amphibole (in Ondor Sum) and muscovite (in Naomuhunni). Blueschists in Manghete contain porphyroblastic albite with inclusions of garnet and epidote in a matrix dominated by calcic-sodic amphibole, epidote, chlorite, albite and muscovite. Phase equilibria modeling for three blueschist samples using pseudosection suggest that the AlM2 contents in sodic amphibole can be used as a good barometer in the limited assemblage involving sodic amphibole + actinolite + epidote + chlorite + albite + quartz under pressures 7-10 kbar. In the sodic amphibole-bearing assemblages, the NaM4 contents in sodic amphibole mainly decrease as temperature rises, being a potential thermometry. The calculated pseudosections constrain the P-T conditions of blueschists to be 3.2-4.2 kbar/355-415 °C in Ondor Sum, 8.2-9.0 kbar/455 °C-495 °C in Manghete and 6.6-8.1 kbar/420-470 °C in Naomuhunni. These P-T estimates indicate a rather high geothermal gradient of 18-25 °C/km for the blueschist metamorphism, being of intermediate P/T facies series. Available zircon U-Pb age data suggests that the protoliths of blueschists were formed later than Late Paleozoic-Early Mesozoic and metamorphosed soon afterwards. An alternative interpretation for the tectonic implication of blueschists in central Inner Mongolia is that they may be a new type attributed to closure of limited ocean basins and do not represent a tectonic regime occurred in conventional subduction setting.

    2. Portföy Yönetiminde Sistematik Olmayan Riski Azaltacak Bir Doğrusal Programlama Model Önerisi

      Directory of Open Access Journals (Sweden)

      Murat UĞURLU

      2016-04-01

      Full Text Available Geleneksel portföy teorisi portföy riskini azaltmak için çeşitlendirmeye önem verirken modern portföy teorisi geçmiş nicel bilgileri kullanarak matematiksel ve istatistiksel yöntemlerle yatırımcıya etkin sınır üzerinde bir portföy oluşturma seçeneğini sunmaktadır. Modern portföy teorisinin öncülerinden Markowitz risk olarak standart sapmayı dikkate almıştır. Seçim yapılacak hisse senetlerinin sayısının çokluğu standart sapma hesaplamalarını zorlaştırmaktadır. Konno ve Yamazaki risk olarak standart sapma yerine mutlak sapmayı kullanmış, böylelikle portföy seçimi doğrusal programlama modeli olarak ifade edilebilmiştir. Her iki model portföye girecek hisse senetlerinin sayısına ve endüstri kollarına dağıtılmasına müdahale edemez. Bu ise oluşacak portföyün, teorik olarak bir tek hisse senedinden oluşmasını mümkün kılabilir. Bu çalışmada, bahsedilen olumsuzluğu gidermek amacıyla Konno ve Yamazaki modeli ilave kısıtlarla genişletilerek yatırımcıya en yüksek beklenen getiriyi sağlayan yeni bir doğrusal programlama modeli önerisi yapılmaktadır.

    3. Equitable access to comprehensive surgical care: the potential of indigenous private philanthropy in low-income settings.

      Science.gov (United States)

      Samad, Lubna; Iqbal, Mehreen; Tariq, Ahson; Shahzad, Wasif; Khan, Aamir J

      2015-01-01

      Equitable access to surgical care is necessary for improving global health. We report on the performance, financial sustainability, and policy impact of a free-of-cost multispecialty surgical delivery program in Karachi, Pakistan built upon local private philanthropy. We evaluated trends in surgical service delivery, expenditures, and philanthropic donations from Indus Hospital's first 5 years of operation (2007-2012), projected these over the hospital's current expansion phase, compared these to publicly accessible records of other philanthropic hospitals providing surgical care, and documented the government's evolving policies toward this model. Between 2007 and 2012, Indus Hospital treated 40,012 in-patients free of cost, 33,606 (84 %) of them for surgical procedures. Surgical procedures increased fivefold to 9,478 during 2011-2012 from 1,838 during 2007-2008. Bed occupancy increased to 91 % from 65 % over the same period. External surgical missions accounted for less than 0.5 % of patients served. Ninety-eight percent (98 %) of all philanthropic donations--totaling USD 26.6 million over 2007-2012--were locally generated. Zakat (obligatory annual religious alms in the Islamic faith) constituted 34 % of all donations, followed by unrestricted funds (24 %) and donations-in-kind (24 %), buildings (12 %), grants (5 %), and return on investments (1 %). Overall, donations received between 2007 and 2012 increased sevenfold, with Zakat increasing 12-fold. During 2013-2014, the Government of Pakistan provided land lease and annual operational grants totaling USD 9 million. Local philanthropy can sustain and grow the provision of free, high-quality surgical care in low-income settings, and encourage the development of hybrid government-philanthropic models of surgical care.

    4. İngiltere’de Kamu Hizmeti Yayıncılığı: Dijital Medya Ortamında BBC’nin Var Olma Mücadelesi

      Directory of Open Access Journals (Sweden)

      Özge Yalçın

      2015-08-01

      Full Text Available BBC ve İngiltere’de BBC uygulamalarına yönelik geliştirilen politika ve stratejiler özellikleneoliberal dönemde ayrı bir önem kazanmıştır. Dünyada ve Avrupa’da bir çok ülkenin kamu hizmeti yayıncısı hızla tasfiye olma konumuna gelirken BBC’nin kendi yayın ilkelerini büyük ölçüde koruyarak dünyada büyük medya devleriyle rekabet edecek düzeye gelmiş olması, BBC’yi Avrupa’da kamu hizmeti yayıncılığına ilişkin getirilen düzenleme ve uygulamalarda önemli bir refarans noktası haline getirmiştir. İngiltere, esas aldığı ikili stratejiyle ya da baş vurduğu kamu değer testi gibi uygulamalarıyla Avrupa Birliği’nin iletişim politikalarının şekillenmesinde belirleyici bir konumda yer almıştır.Bu araştırma İngiltere’de neoliberal dönemde kamu hizmeti yayıncılığının konumunu esas alınan politikalar getirilen düzenlemeler ve uygulamaları ele alarak tartışmakta, Avrupa Birliği ve üye ülkelere etkisini analiz etmeye çalışmaktadır. 

    5. Tropical forest response to a drier future: Measurement and modeling of soil organic matter stocks and turnover

      Science.gov (United States)

      Finstad, K. M.; Campbell, A.; Pett-Ridge, J.; Zhang, N.; McFarlane, K. J.

      2017-12-01

      Tropical forests account for over 50% of the global terrestrial carbon sink and 29% of global soil carbon, but the stability of carbon in these ecosystems under a changing climate is unknown. Recent work suggests moisture may be more important than temperature in driving soil carbon storage and emissions in the tropics. However, data on belowground carbon cycling in the tropics is sparse, and the role of moisture on soil carbon dynamics is underrepresented in current land surface models limiting our ability to extrapolate from field experiments to the entire region. We measured radiocarbon (14C) and calculated turnover rates of organic matter from 37 soil profiles from the Neotropics including sites in Mexico, Brazil, Costa Rica, Puerto Rico, and Peru. Our sites represent a large range of moisture, spanning 710 to 4200 mm of mean annual precipitation, and include Andisols, Oxisols, Inceptisols, and Ultisols. We found a large range in soil 14C profiles between sites, and in some locations, we also found a large spatial variation within a site. We compared measured soil C stocks and 14C profiles to data generated from the Community Land Model (CLM) v.4.5 and have begun to generate data from the ACME Land Model (ALM) v.1. We found that the CLM consistently overestimated carbon stocks and the mean age of soil carbon at the surface (upper 50 cm), and underestimated the mean age of deep soil carbon. Additionally, the CLM did not capture the variation in 14C and C stock profiles that exists between and within the sites across the Neotropics. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-736060.

    6. Development and construction of a specific chamber for phototoxicity test

      Energy Technology Data Exchange (ETDEWEB)

      Sufi, Bianca S.; Mathor, Monica B., E-mail: biancasufi@usp.br, E-mail: mathor@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Esteves-Pedro, Natalia M.; Kaneko, Telma Mary, E-mail: nataliamenves@yahoo.com.br, E-mail: tsakuda@usp.br [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Fac. de Ciencias Farmaceuticas; Lopes, Patricia, E-mail: patricia.lopes@unifesp.br [Universidade Federal de Sao Paulo (UNIFESP), Diadema, SP (Brazil)

      2013-07-01

      Phototoxicity corresponds to the acute toxic response induced after skin exposure 'in vivo' and 'ex vivo' to certain chemicals and subsequent exposure to irradiation. Phototoxicity 'in vitro' assay is determined by viability of fibroblasts BALB/c 3T3 exposed to chemicals in the presence and absence of light. Substances identified as phototoxic are susceptible to 'in vivo' phototoxicity (OECD 432, 2004). A chamber was developed and constructed according to the guidelines OECD Toxicity Guide - 432 and ®ECVAM DB-ALM: INVITTOX N. 78. The chamber was built in stainless steel frame, with UVA lamps and dark area for negative control. The tests to qualify the chamber were performed with Sodium Lauryl Sulfate, recommended by the guides aforementioned, as negative control; and Bergamot oil (Givaudan-Roche), as positive control. Bergamot, Citrus bergamia, has, as major component, Bergapten responsible for its photosensitive activity. Both samples were diluted in Phosphate Buffered Saline with concentrations between 0.005 and 0.1 mg/mL, which were calculated by the dilution factor 1.47. These tests were performed over fibroblast BALB/c 3T3 culture and submitted to phototoxicity assay with MTS dye, under spectrophotometric reading, which allows determining the Photo Irritation Factor (PIF), what suggests that a substance with a PIF<2 predicts no phototoxicity; PIF>2 and <5 provides likely phototoxicity and PIF>5 provides phototoxicity. Sodium Lauryl Sulfate presented a PIF=1, being in accordance with the OECD. Bergamot oil has shown to be likely phototoxic with a PIF=2,475. These results provide that the chamber is qualified to be used to perform phototoxicity tests with assurance and security. (author)

    7. Development and construction of a specific chamber for phototoxicity test

      International Nuclear Information System (INIS)

      Sufi, Bianca S.; Mathor, Monica B.; Esteves-Pedro, Natalia M.; Kaneko, Telma Mary

      2013-01-01

      Phototoxicity corresponds to the acute toxic response induced after skin exposure 'in vivo' and 'ex vivo' to certain chemicals and subsequent exposure to irradiation. Phototoxicity 'in vitro' assay is determined by viability of fibroblasts BALB/c 3T3 exposed to chemicals in the presence and absence of light. Substances identified as phototoxic are susceptible to 'in vivo' phototoxicity (OECD 432, 2004). A chamber was developed and constructed according to the guidelines OECD Toxicity Guide - 432 and ®ECVAM DB-ALM: INVITTOX N. 78. The chamber was built in stainless steel frame, with UVA lamps and dark area for negative control. The tests to qualify the chamber were performed with Sodium Lauryl Sulfate, recommended by the guides aforementioned, as negative control; and Bergamot oil (Givaudan-Roche), as positive control. Bergamot, Citrus bergamia, has, as major component, Bergapten responsible for its photosensitive activity. Both samples were diluted in Phosphate Buffered Saline with concentrations between 0.005 and 0.1 mg/mL, which were calculated by the dilution factor 1.47. These tests were performed over fibroblast BALB/c 3T3 culture and submitted to phototoxicity assay with MTS dye, under spectrophotometric reading, which allows determining the Photo Irritation Factor (PIF), what suggests that a substance with a PIF 2 and 5 provides phototoxicity. Sodium Lauryl Sulfate presented a PIF=1, being in accordance with the OECD. Bergamot oil has shown to be likely phototoxic with a PIF=2,475. These results provide that the chamber is qualified to be used to perform phototoxicity tests with assurance and security. (author)

    8. The influence of the iron content on the reductive decomposition of A{sub 3−x}Fe{sub x}Al{sub 2}Si{sub 3}O{sub 12} garnets (A = Mg, Mn; 0.47 ≤ x ≤ 2.85)

      Energy Technology Data Exchange (ETDEWEB)

      Aparicio, Claudia, E-mail: claudia.aparicio@upol.cz; Filip, Jan, E-mail: claudia.aparicio@upol.cz; Mashlan, Miroslav, E-mail: claudia.aparicio@upol.cz; Zboril, Radek, E-mail: claudia.aparicio@upol.cz [Regional Centre of Advanced Technologies and Materials, Departments of Experimental Physics and Physical Chemistry, Faculty of Science, Palacky University, 17. listopadu 1192/12, 77146 Olomouc (Czech Republic)

      2014-10-27

      Thermally-induced reductive decomposition of natural iron-bearing garnets of the almandine-pyrope and almandine-spessartine series were studied at temperatures up to 1200 °C (heating rate of 10 °C/min) under atmosphere of forming gas (10% of H{sub 2} in N{sub 2}). Crystallochemical formula of the studied garnet was calculated as {sup VIII}(A{sub 3−x}Fe{sub x}{sup 2+}){sup VI}(Al,Fe{sup 3+}){sub 2}Si{sub 3}O{sub 12}, where the amount of Fe{sup 3+} in the octahedral sites is negligible with the exception of pyrope, A = Mg, Mn, and 0.47 ≤ x ≤ 2.85. The observed decomposition temperature, determined from differential scanning calorimetry and thermogravimetry, is greater than 1000 °C in all cases and showed almost linear dependence on the iron content in the dodecahedral sites of the studied garnets, with the exception of garnet with a near-pyrope composition (Prp{sub 80}Alm{sub 20}). The initial garnet samples and decomposition products were characterized in details by means of X-ray powder diffraction and {sup 57}Fe Mössbauer spectroscopy. We found that all studied garnets have common decomposition products such as metallic iron (in general, rounded particles below 4 μm) and Fe-spinel; the other identified decomposition products depend on starting chemical composition of the garnet: Fe-cordierite, olivine (fayalite or tephroite), cristobalite, pyroxene (enstatite or pigeonite), and anorthite. Anorthite and pigeonite were only present in garnets with Ca in the dodecahedral site. All the identified phases were usually well crystallized.

    9. Farklı Oranlarda Kalsiyum Karbonat Kullanımının Yoğurdun Fiziksel, Kimyasal ve Duyusal Özellikleri Üzerine Etkisi (İngilizce

      Directory of Open Access Journals (Sweden)

      Fatma Coskun

      2015-02-01

      Full Text Available Bu araştırmada süte farklı oranlarda CaCO3 ilave ederek zenginleştirme işlemi uygulanmıştır. Takviye işlemi kalsiyum karbonatın farklı seviyeleriyle (200, 400, 600 mg/100ml sütün pastörizasyonundan önce ve sonra uygulanmıştır. İlave edilen kalsiyum karbonatın zenginleştirilmiş yoğurt örneklerine etkisi depolama periyodu boyunca belirlenmiştir (21 gün, 4 °C’de. İlave edilen kalsiyum karbonat yoğurdun pH değerini ve viskozitesini artırmış, titrasyon asitliğini ve serum ayrılması değerini düşürmüştür. Sonuçlar istatistiksel olarak önemli bulunmuştur (P<0.05. En iyi sonuçlar kalsiyum karbonatın pastörizasyondan önce ilave edilmesiyle elde edilmiştir. Duyusal değerlendirme sonucunda, pastörizasyon öncesi kalsiyum karbonat ilave edilmiş örnekler ve kontrol örnekleri diğerlerine göre daha yüksek puanlar almıştır. İlave edilen kalsiyum karbonatın artan değerleri yoğurdun fiziksel ve kimyasal özelliklerini pozitif olarak etkilerken, yoğurdun duyusal özelliklerini negatif olarak etkilemiştir. İlave konsantrasyonlar 400mg/100ml’yi aşmamalıdır.

    10. Probabilistic Model for Integrated Assessment of the Behavior at the T.D.P. Version 2; Modelo Probabilista de Evaluación Integrada del Comportamiento de la P.D.T. Versión 2

      Energy Technology Data Exchange (ETDEWEB)

      Hurtado, A.; Eguilior, S.; Recreo, F

      2015-07-01

      This report documents the completion of the first phase of the implementation of the methodology ABACO2G (Bayes Application to Geological Storage of CO2) and the final version of the ABACO2G probabilistic model for the injection phase before its future validation in the experimental field of the Technology Development Plant in Hontom (Burgos). The model, which is based on the determination of the probabilistic risk component of a geological storage of CO2 using the formalism of Bayesian networks and Monte Carlo probability yields quantitative probability functions of the total system CO2 storage and of each one of their subsystems (storage subsystem and the primary seal; secondary containment subsystem and dispersion subsystem or tertiary one); the implementation of the stochastic time evolution of the CO2 plume during the injection period, the stochastic time evolution of the drying front, the probabilistic evolution of the pressure front, decoupled from the CO2 plume progress front, and the implementation of submodels and leakage probability functions through major leakage risk elements (fractures / faults and wells / deep boreholes) which together define the space of events to estimate the risks associated with the CO2 geological storage system. The activities included in this report have been to replace the previous qualitative estimation submodels of former ABACO2G version developed during Phase I of the project ALM-10-017, by analytical, semi-analytical or numerical submodels for the main elements of risk (wells and fractures), to obtain an integrated probabilistic model of a CO2 storage complex in carbonate formations that meets the needs of the integrated behavior evaluation of the Technology Development Plant in Hontomín.

    11. Dietary modification dampens liver inflammation and fibrosis in obesity-related fatty liver disease.

      Science.gov (United States)

      Larter, Claire Z; Yeh, Matthew M; Haigh, W Geoffrey; Van Rooyen, Derrick M; Brooling, John; Heydet, Deborah; Nolan, Christopher J; Teoh, Narci C; Farrell, Geoffrey C

      2013-06-01

      Alms1 mutant (foz/foz) mice develop hyperphagic obesity, diabetes, metabolic syndrome, and fatty liver (steatosis). High-fat (HF) feeding converts pathology from bland steatosis to nonalcoholic steatohepatitis (NASH) with fibrosis, which leads to cirrhosis in humans. We sought to establish how dietary composition contributes to NASH pathogenesis. foz/foz mice were fed HF diet or chow 24 weeks, or switched HF to chow after 12 weeks. Serum ALT, NAFLD activity score (NAS), fibrosis severity, neutrophil, macrophage and apoptosis immunohistochemistry, uncoupling protein (UCP)2, ATP, NF-κB activation/expression of chemokines/adhesion molecules/fibrogenic pathways were determined. HF intake upregulated liver fatty acid and cholesterol transporter, CD36. Dietary switch expanded adipose tissue and decreased hepatomegaly by lowering triglyceride, cholesterol ester, free cholesterol and diacylglyceride content of liver. There was no change in lipogenesis or fatty acid oxidation pathways; instead, CD36 was suppressed. These diet-induced changes in hepatic lipids improved NAS, reduced neutrophil infiltration, normalized UCP2 and increased ATP; this facilitated apoptosis with a change in macrophage phenotype favoring M2 cells. Dietary switch also abrogated NF-κB activation and chemokine/adhesion molecule expression, and arrested fibrosis by dampening stellate cell activation. Reversion to a physiological dietary composition after HF feeding in foz/foz mice alters body weight distribution but not obesity. This attenuates NASH severity and fibrotic progression by suppressing NF-κB activation and reducing neutrophil and macrophage activation. However, adipose inflammation persists and is associated with continuing apoptosis in the residual fatty liver disease. Taken together, these findings indicate that other measures, such as weight reduction, may be required to fully reverse obesity-related NASH. Copyright © 2013 The Obesity Society.

    12. Logistics Reduction and Repurposing Technology for Long Duration Space Missions

      Science.gov (United States)

      Broyan, James L.; Chu, Andrew; Ewert, Michael K.

      2014-01-01

      One of NASA's Advanced Exploration Systems (AES) projects is the Logistics Reduction and Repurposing (LRR) project, which has the goal of reducing logistics resupply items through direct and indirect means. Various technologies under development in the project will reduce the launch mass of consumables and their packaging, enable reuse and repurposing of items and make logistics tracking more efficient. Repurposing also reduces the trash burden onboard spacecraft and indirectly reduces launch mass by replacing some items on the manifest. Examples include reuse of trash as radiation shielding or propellant. This paper provides the status of the LRR technologies in their third year of development under AES. Advanced clothing systems (ACS) are being developed to enable clothing to be worn longer, directly reducing launch mass. ACS has completed a ground exercise clothing study in preparation for an International Space Station (ISS) technology demonstration in 2014. Development of launch packaging containers and other items that can be repurposed on-orbit as part of habitation outfitting has resulted in a logistics-to-living (L2L) concept. L2L has fabricated and evaluated several multi-purpose cargo transfer bags (MCTBs) for potential reuse on orbit. Autonomous logistics management (ALM) is using radio frequency identification (RFID) to track items and thus reduce crew requirements for logistics functions. An RFID dense reader prototype is under construction and plans for integrated testing are being made. Development of a heat melt compactor (HMC) second generation unit for processing trash into compact and stable tiles is nearing completion. The HMC prototype compaction chamber has been completed and system development testing is underway. Research has been conducted on the conversion of trash-to-gas (TtG) for high levels of volume reduction and for use in propulsion systems. A steam reformation system was selected for further system definition of the TtG technology

    13. The effect of location on the microstructure and mechanical properties of titanium aluminides produced by additive layer manufacturing using in-situ alloying and gas tungsten arc welding

      Energy Technology Data Exchange (ETDEWEB)

      Ma, Yan; Cuiuri, Dominic; Hoye, Nicholas; Li, Huijun; Pan, Zengxi, E-mail: zengxi@uow.edu.au

      2015-04-17

      An innovative and low cost additive layer manufacturing (ALM) process is used to produce γ-TiAl based alloy wall components. Gas tungsten arc welding (GTAW) provides the heat source for this new approach, combined with in-situ alloying through separate feeding of commercially pure Ti and Al wires into the weld pool. This paper investigates the morphology, microstructure and mechanical properties of the additively manufactured TiAl material, and how these are affected by the location within the manufactured component. The typical additively layer manufactured morphology exhibits epitaxial growth of columnar grains and several layer bands. The fabricated γ-TiAl based alloy consists of comparatively large α{sub 2} grains in the near-substrate region, fully lamellar colonies with various sizes and interdendritic γ structure in the intermediate layer bands, followed by fine dendrites and interdendritic γ phases in the top region. Microhardness measurements and tensile testing results indicated relatively homogeneous mechanical characteristics throughout the deposited material. The exception to this homogeneity occurs in the near-substrate region immediately adjacent to the pure Ti substrate used in these experiments, where the alloying process is not as well controlled as in the higher regions. The tensile properties are also different for the vertical (build) direction and horizontal (travel) direction because of the differing microstructure in each direction. The microstructure variation and strengthening mechanisms resulting from the new manufacturing approach are analysed in detail. The results demonstrate the potential to produce full density titanium aluminide components directly using the new additive layer manufacturing method.

    14. The effect of location on the microstructure and mechanical properties of titanium aluminides produced by additive layer manufacturing using in-situ alloying and gas tungsten arc welding

      International Nuclear Information System (INIS)

      Ma, Yan; Cuiuri, Dominic; Hoye, Nicholas; Li, Huijun; Pan, Zengxi

      2015-01-01

      An innovative and low cost additive layer manufacturing (ALM) process is used to produce γ-TiAl based alloy wall components. Gas tungsten arc welding (GTAW) provides the heat source for this new approach, combined with in-situ alloying through separate feeding of commercially pure Ti and Al wires into the weld pool. This paper investigates the morphology, microstructure and mechanical properties of the additively manufactured TiAl material, and how these are affected by the location within the manufactured component. The typical additively layer manufactured morphology exhibits epitaxial growth of columnar grains and several layer bands. The fabricated γ-TiAl based alloy consists of comparatively large α 2 grains in the near-substrate region, fully lamellar colonies with various sizes and interdendritic γ structure in the intermediate layer bands, followed by fine dendrites and interdendritic γ phases in the top region. Microhardness measurements and tensile testing results indicated relatively homogeneous mechanical characteristics throughout the deposited material. The exception to this homogeneity occurs in the near-substrate region immediately adjacent to the pure Ti substrate used in these experiments, where the alloying process is not as well controlled as in the higher regions. The tensile properties are also different for the vertical (build) direction and horizontal (travel) direction because of the differing microstructure in each direction. The microstructure variation and strengthening mechanisms resulting from the new manufacturing approach are analysed in detail. The results demonstrate the potential to produce full density titanium aluminide components directly using the new additive layer manufacturing method

    15. Agricultural terraces montoring and modeling: a field survey in Chianti region, Firenze, Italy - First part

      Science.gov (United States)

      Preti, Federico; Caruso, Marco; Dani, Andrea; Errico, Alessandro; Guastini, Enrico; Trucchi, Paolo

      2015-04-01

      The two abstracts present the design and set-up of an experimental field plant whose aim is the study and modeling of water circulation in a terraced slope together with its influence on the stability of the retaining dry stone walls. The pilot plant is located at "Fattoria di Lamole" (Greve in Chianti, Firenze, Italy) where both ancient and recently restored or rebuilt dry stone retaining walls are present. The intense vineyards cultivation makes it very representative in terms of range of external stresses that affect both hillslopes and walls. The research is developed within a bigger framework of landscape preservation as a way to prevent hydrogeological instabilities and landslide risks. First Part A first/preliminary field survey was carried out in order to estimate the hydraulic and mechanical soil characteristics. Field saturated hydraulic conductivity measurements with the Simplified Falling Head (SFH) method on a terrace along an alignment were performed. Infiltrometer tests with a double ring device and soil texture determinations with both fine particle-size and skeleton fraction distributions were also performed. The Direct shear test on undisturbed and reconstituted soil samples will offer an estimation of the Mohr-Coulomb failure envelope parameters (friction angle and cohesion). A reference portion of a dry stone wall will be also monitored. Lateral earth pressure at backfill-retaining wall interface (compared to temperature and air pressure measured values), backfill volumetric water content (both in saturated and unsaturated states) and ground-water level are measured. Acknowledgements Italian Research Project of Relevant Interest (PRIN2010-2011), prot. 20104ALME4, National network for monitoring, modeling, and sustainable management of erosion processes in agricultural land and hilly-mountainous area

    16. Agricultural terraces montoring and modeling: a field survey in Chianti region, Firenze, Italy – Second part

      Science.gov (United States)

      Preti, Federico; Caruso, Marco; Dani, Andrea; Cassiani, Giorgio; Romano, Nunzio; Tarolli, Paolo

      2015-04-01

      The two abstracts present the design and set-up of an experimental campaign which aims at sup-porting the modeling (conceptual and numerical) of water circulation in a terraced slope, and its in-fluence on stability of retaining dry stone walls. The case study is located at "Fattoria di Lamole" (Greve in Chianti, Firenze, Italy). At Lamole site both ancient and recently restored or rebuilt (with different techniques) dry stone walls are present. Furthermore the intense vineyards cultivation makes it very representative in terms of range of external stresses that affect both hillslopes and wall. The survey is developed within the bigger framework of landscape preservation as a way to prevent hydrogeological instabilities and landslide risks. Second Part A second effort is devoted to couple hydrological, hydraulic and geotechnical modeling: - Flow directions and the drainage area have been derived from DTM (high-resolution digital terrain model obtained by a terrestrial laser scanner.), and served for the RPII index calcula-tion (Tarolli et al., 2013), that is coherent with the critical spots observed in situ and marked with GPS. - Direct shear test on undisturbed and reconstituted soil samples will offer an estimation of the Mohr-Coulomb failure envelope parameters (friction angle and cohesion). - Retention curves related with different depths have been derived. - Geoelectric analysis in order to locate the bedrock and to determine the subterranean water flows originated from controlled infitration tests (1 l/s discharge). - A simple dry-wall stability model has been carried out; this model analyses the wall stability with finite elements method, evaluating pressures derived from uphill water infiltration, stone friction and buoyancy in retaining wall layers: simulated deformation are suitable with the observed ones. Acknowledgements Italian Research Project of Relevant Interest (PRIN2010-2011), prot. 20104ALME4, National network for monitoring, modeling, and

    17. Şemseddin Sivȃsȋ’nin Tasavvufȋ Tecrübesinde Rizȃ-yı Bȃrȋ Düşüncesi

      Directory of Open Access Journals (Sweden)

      Kadir Özköse

      2015-12-01

      Full Text Available Halvetiyyenin dört ana kolundan biri olan Şemsiyyenin pȋri konumundaki Şemseddin Sivȃsȋ’nin eserlerinden hareketle hazırladığımız bu makale Şemseddin Sivȃsȋ’nin sȗfȋ tecrübesini okumaya dönük bir çalışmadır. Mensur ve manzum eserlerinin herbirinde Şemseddin Sivȃsȋ ana tema olarak Allah’ın rızasını merkeze almıştır. İlahi rızanın her zaman gündemde olmasını, kulluğun ilahi rıza ekseninde gerçekleşmesini istemiştir. Lutfun da hoş kahrın da hoş anlayışına bağlı olan Şemseddin Sivȃsȋ ilahi takdire boyun eğmiş, ne varlığa sevinmeyi ne de yokluktan yerinmeyi öngörmüştür. Rıza halinin kemalini o, mücahede eğitimne, sabır ve sebat gayretine, tevazu duygusuna, ihlas hassasiyetine ve zikir diriliğine bağlamıştır. Makalemizde Şemseddin Sivȃsȋ’nin rızanın ehemmiyetine ve rıza makamına ulaşmayı sağlayan teel ölçütlere dikkat çekmeye çalıştık.

    18. Rare earth metal bis(amide) complexes bearing amidinate ancillary ligands: synthesis, characterization, and performance as catalyst precursors for cis-1,4 selective polymerization of isoprene.

      Science.gov (United States)

      Luo, Yunjie; Fan, Shimin; Yang, Jianping; Fang, Jianghua; Xu, Ping

      2011-03-28

      A family of rare earth metal bis(amide) complexes bearing monoanionic amidinate [RC(N-2,6-Me(2)C(6)H(3))(2)](-) (R = cyclohexyl (Cy), phenyl (Ph)) as ancillary ligands were synthesized and characterized. One-pot salt metathesis reaction of anhydrous LnCl(3) with one equivalent of amidinate lithium [RC(N-2,6-Me(2)C(6)H(3))(2)]Li, following the introduction of two equivalents of NaN(SiMe(3))(2) in THF at room temperature afforded the neutral and unsolvated mono(amidinate) rare earth metal bis(amide) complexes [RC(N-2,6-Me(2)C(6)H(3))(2)]Y[N(SiMe(3))(2)](2) (R = Cy (1); R = Ph (2)), and the "ate" mono(amidinate) rare earth metal bis(amide) complex [CyC(N-2,6-Me(2)C(6)H(3))(2)]Lu[N(SiMe(3))(2)](2)(μ-Cl)Li(THF)(3) (3) in 61-72% isolated yields. These complexes were characterized by elemental analysis, NMR spectroscopy, FT-IR spectroscopy, and X-ray single crystal diffraction. Single crystal structural determination revealed that the central metal in complexes 1 and 2 adopts a distorted tetrahedral geometry, and in complex 3 forms a distorted trigonal bipyramidal geometry. In the presence of AlMe(3), and in combination with one equimolar amount of [Ph(3)C][B(C(6)F(5))(4)], complexes 1 and 2 showed high activity towards isoprene polymerization to give high molecular weight polyisoprene (M(n) > 10(4)) with good cis-1,4 selectivity (>90%).

    19. Eugenol Katkılı Aynalı Sazan Balığı Köftelerinin Raf Ömrünün Belirlenmesi

      Directory of Open Access Journals (Sweden)

      Özlem Pelin CAN

      2014-07-01

      Full Text Available Bu çalışmada, aynalı sazan balığından (Cyprinus carpio L., 1758 elde edilen kıymaya çeşitli katkı maddeleri ilave edilerek balık köftesi yapılmıştır. Köfteler biri kontrol (grup A olmak üzere, diğerlerine %0.5 (grup B ve %1(grup C oranlarında eugenol ilave edilerek üç gruba ayrılmıştır. Muhafaza süresi boyunca meydana gelen mikrobiyolojik, kimyasal ve duyusal değişimler incelenmiştir. Mikrobiyolojik analiz sonuçlarına göre A grubu B ve C grubuyla karşılaştırıldığında değerler yüksek bulunmuştur (P<0.05. İstatistiksel olarak C grubu örneklerinde enterobakteriler, maya, küf ve mezofil aerob bakteri sayısı daha düşük bulunmuştur (P<0.05. TVB-N ve TBA değerleri üç grupta muhafaza süresi boyunca yükselmiştir. Duyusal değerlendirmede, C grubu örnekleri düşük puan almıştır. Sonuç olarak, yüksek konsantrasyon içeren grup (C grubu, mikrobiyolojik ve kimyasal olarak iyi kalitede olmasına rağmen duyusal değerlendirme sonuçlarına göre tüketilmesi uygun değildir.

    20. An evaluation of thermal-hydrodynamics for condensation pool and piping system

      Energy Technology Data Exchange (ETDEWEB)

      Kwon, Soon Bum; Lee, B. E.; Baek, S. C.; Joo, S. Y.; Lee, D. E.; Woo, S. W. [Kyungpook National Univ., Daegu (Korea, Republic of)

      2003-03-15

      If the steam with high pressure and high temperature at APR-1400 is discharged into IRWST through, the spargers submerged into it to release the pressure of coolant system 10 accident. The shock wave accompanying unsteady flow motion is propagated through the various piping system, it exerts high pressure load on units and may cause the structural problems and severe vibration. From the viewpoint of nuclear power plant safety, The analysis of flow behaviors 10 the IRWST and piping system is essential to achieve the technology for the evaluation of safety. And also he evaluation methods by the analysis of thermal hydrodynamic behaviors through the sparger is established. The results obtained show that the initial shock wave experienced reflection, diffraction and interaction with shock-induced vortex. The time-dependent maximum load exerted on the wall is largest 10 the T-junction, while the smallest 10 the branch. It is found that because there is nearly no change 10 pressure at condensation pool during water clearing, the system appears to be safe. However, calculations of the air clearing for 0.2 second were performed using VOF model to analyze air that coexist with water between load reduction and sparger head. In addition, since actual POSRV opening takes finite time of 1.7 second, it is expected that the flow field will be different from the that of instant opening the valve. Therefore, now the grid generation is proceeded for the case of POSRV opening at finite time of 1.7 second consecutively. The future study alms at flow analysis of POSRV opening at finite time, changing boundary conditions for wall into pressure inlet.

    1. Probabilistic Model for Integrated Assessment of the Behavior at the T.D.P. Version 2

      International Nuclear Information System (INIS)

      Hurtado, A.; Eguilior, S.; Recreo, F

      2015-01-01

      This report documents the completion of the first phase of the implementation of the methodology ABACO2G (Bayes Application to Geological Storage of CO2) and the final version of the ABACO2G probabilistic model for the injection phase before its future validation in the experimental field of the Technology Development Plant in Hontom (Burgos). The model, which is based on the determination of the probabilistic risk component of a geological storage of CO2 using the formalism of Bayesian networks and Monte Carlo probability yields quantitative probability functions of the total system CO2 storage and of each one of their subsystems (storage subsystem and the primary seal; secondary containment subsystem and dispersion subsystem or tertiary one); the implementation of the stochastic time evolution of the CO2 plume during the injection period, the stochastic time evolution of the drying front, the probabilistic evolution of the pressure front, decoupled from the CO2 plume progress front, and the implementation of submodels and leakage probability functions through major leakage risk elements (fractures / faults and wells / deep boreholes) which together define the space of events to estimate the risks associated with the CO2 geological storage system. The activities included in this report have been to replace the previous qualitative estimation submodels of former ABACO2G version developed during Phase I of the project ALM-10-017, by analytical, semi-analytical or numerical submodels for the main elements of risk (wells and fractures), to obtain an integrated probabilistic model of a CO2 storage complex in carbonate formations that meets the needs of the integrated behavior evaluation of the Technology Development Plant in Hontomín

    2. A Next Generation Sequencing custom gene panel as first line diagnostic tool for atypical cases of syndromic obesity: Application in a case of Alström syndrome.

      Science.gov (United States)

      Maltese, Paolo E; Iarossi, Giancarlo; Ziccardi, Lucia; Colombo, Leonardo; Buzzonetti, Luca; Crinò, Antonino; Tezzele, Silvia; Bertelli, Matteo

      2018-02-01

      Obesity phenotype can be manifested as an isolated trait or accompanied by multisystem disorders as part of a syndromic picture. In both situations, same molecular pathways may be involved to different degrees. This evidence is stronger in syndromic obesity, in which phenotypes of different syndromes may overlap. In these cases, genetic testing can unequivocally provide a final diagnosis. Here we describe a patient who met the diagnostic criteria for Alström syndrome only during adolescence. Genetic testing was requested at 25 years of age for a final confirmation of the diagnosis. The genetic diagnosis of Alström syndrome was obtained through a Next Generation Sequencing genetic test approach using a custom-designed gene panel of 47 genes associated with syndromic and non-syndromic obesity. Genetic analysis revealed a novel homozygous frameshift variant p.(Arg1550Lysfs*10) on exon 8 of the ALMS1 gene. This case shows the need for a revision of the diagnostic criteria guidelines, as a consequence of the recent advent of massive parallel sequencing technology. Indications for genetic testing reported in these currently accepted diagnostic criteria for Alström syndrome, were drafted when sequencing was expensive and time consuming. Nowadays, Next Generation Sequencing testing could be considered as first line diagnostic tool not only for Alström syndrome but, more generally, for all those atypical or not clearly distinguishable cases of syndromic obesity, thus avoiding delayed diagnosis and treatments. Early diagnosis permits a better follow-up and pre-symptomatic interventions. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

    3. ‘Hawaii, Hawaii/ Like a dream/ So I came/ But my tears/ Are flowing now/In the canefields’: Beauty’s Price in Philip Kan Gotanda’s Ballad of Yachiyo

      Directory of Open Access Journals (Sweden)

      María Isabel Seguro

      2009-06-01

      Full Text Available Oftentimes popular culture depicts Hawaii as an ideal paradise, represented by images of ‘[p]alm trees, a distant mountain (frequently a smoking volcano, and a hula maiden, all surmounted by a splendid full moon’ (Brown 1994. Such a picture clearly contrasts with the labour song quoted in the title of this article, which reflects the exploitation, mainly of Asian workers, in the sugar-cane plantation system—the original basis for (white American prosperity in the islands since the mid-nineteenth century. Philip Kan Gotanda’s play, Ballad of Yachiyo, which premièred at Berkeley Repertory Theatre in 1995, takes place within a Japanese community in early twentieth-century Hawaii. It is loosely based on the silenced story of the playwright’s aunt who committed suicide for bringing shame to the family as a result of an extra-marital pregnancy. Gotanda considers that this particular work is not so much about politics, but about ‘a tone’ and a ‘kind of beautiful sadness’ (1997. Despite the author’s words, Ballad of Yachiyo inevitably has embedded within a political message insofar as it makes references, for example, to working conditions in the sugar plantations, the formation of the first inter-ethnic (Japanese/Filipino trade unions and the expectations of Japanese immigrants in search of the mythical paradise Hawaii was meant to be. That is, by recovering what was once a lost voice, Gotanda reconstructs part of his family’s memory as forming part of Hawaii’s recent history.

    4. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

      Directory of Open Access Journals (Sweden)

      Carsten A Böger

      2011-09-01

      Full Text Available Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD and end stage renal disease (ESRD. Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m(2 at follow-up and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls. SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1. SNPs in UMOD (OR = 0.92, p = 0.04 and GCKR (OR = 0.93, p = 0.03 were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

    5. Influence of landscape heterogeneity on water available to tropical forests in an Amazonian catchment and implications for modeling drought response

      Science.gov (United States)

      Fang, Yilin; Leung, L. Ruby; Duan, Zhuoran; Wigmosta, Mark S.; Maxwell, Reed M.; Chambers, Jeffrey Q.; Tomasella, Javier

      2017-08-01

      The Amazon basin has experienced periodic droughts in the past, and intense and frequent droughts are predicted in the future. Landscape heterogeneity could play an important role in how tropical forests respond to drought by influencing water available to plants. Using the one-dimensional ACME Land Model and the three-dimensional ParFlow variably saturated flow model, numerical experiments were performed for a catchment in central Amazon to elucidate processes that influence water available for plant use and provide insights for improving Earth system models. Results from ParFlow show that topography has a dominant influence on groundwater table and runoff through lateral flow. Without any representations of lateral processes, ALM simulates very different seasonal variations in groundwater table and runoff compared to ParFlow even if it is able to reproduce the long-term spatial average groundwater table of ParFlow through simple parameter calibration. In the ParFlow simulations, even in the plateau with much deeper water table depth during the dry season in the drought year of 2005, plant transpiration is not water stressed as the soil saturation is still sufficient for the stomata to be fully open based on the empirical wilting formulation in the models. This finding is insensitive to uncertainty in atmospheric forcing and soil parameters, but the empirical wilting formulation is an important factor that should be addressed using observations and modeling of coupled plant hydraulics-soil hydrology processes in future studies. The results could be applicable to other catchments in the Amazon basin with similar seasonal variability and hydrologic regimes.

    6. «Dejarlo todo por Dios, es comprar el cielo»: El voto de pobreza, la mendicidad y el asistencialismo entre los dominicos castellanos (1460-1550

      Directory of Open Access Journals (Sweden)

      Nieva Ocampo, Guillermo

      2009-12-01

      Full Text Available In the days of the reform, the Castilian Dominican convents experienced a strong increase of their patrimony, thanks to a favorable conjuncture. The superiors of those Convents considered that the possession of such goods was necessary for the maintenance of the community and subsistence of friars that were eminently intellectual. The embellishment and expansion of the convents’ areas, in turn, at a time when strict poverty was proclaimed, were due to the sacred value granted to the building. Nevertheless, those same prelates made an enormous effort to make sure that the friar was conscious that the vow of poverty turned him, in personal terms, into a poor man. On the other hand, the spirituality of the Dominicans considered the poor –who were associated with Christ– as a redemptive means, which led to the practice of alms.En tiempos de la reforma, gracias a una coyuntura favorable, los conventos dominicos castellanos experimentaron un fuerte acrecentamiento de su patrimonio. Los superiores conventuales consideraron necesaria la posesión de esos bienes para el mantenimiento de la comunidad y subsistencia de unos frailes eminentemente intelectuales. A su vez, el embellecimiento y la ampliación del recinto de los conventos, en una época que pregonaba la estricta pobreza, fue deudora de una valoración sagrada otorgada al edificio. Sin embargo, esos mismos prelados hicieron un esfuerzo ingente por asegurarse que el fraile fuera consciente que el voto de pobreza lo convertía, a título personal, en un pobre. Por otra parte, la espiritualidad de los dominicos consideró a los pobres –a los que asoció con Cristo- como un medio redentor, de allí la práctica de la limosna.

    7. There is also a story in Lutosławski: Narrative archetypes in the first movement of Witold Lutosławski's second symphony

      Directory of Open Access Journals (Sweden)

      Zatkalik Miloš

      2016-01-01

      Full Text Available Narrativity in music is seldom connected to the compositions based on aleatoric procedures and the use of sound masses. Yet, it can be demonstrated that the first movement of Witold Lutosławski's Second Symphony projects a meaningful set of relations which is later called into question and reconfigured, thus meeting at least some of the conditions for narratological approach. The attention is focused on the tone pitch parameter and in that sense it can be noticed that the movement is founded on the alternation of twelve-note aggregate and symmetrical, all-combinatorial hexachord 012678. This description suggests invariance, the lack of directed movement, since both tonal arrays are characterised by a high level of entropy. In spite of this, there is a clear effort to achieve a directed movement, as a result of the procedures used to organise tonal pitches, and, especially, as a result of the treatment of hexachords. The paper will investigate how the flow of events in this movement can be related to the system of mythos - the archetypal narrative categories - as were first defined by the Canadian literary critic Northrop Frye, and adjusted for musical narrative by Byron Almén. The system is based on the intersection of the two fundamental opposites: defeat/victory and order/disorder, resulting in four categories: comedy, romance, irony/satire and tragedy. No matter how paradoxical it may seem, it is the abovementioned entropy that can be considered as the initial order, and its disorder is achieved by attempts to establish directed movement. The ambivalence of archetypal categories and their interweaving is not uncommon in the narrative process. Therefore, the possibility of various interpretations of narrative trajectory will be discussed.

    8. Bina Enerji Analiz Yazılımlarının HVAC Sistemlerindeki Hatalarını Azaltmak Ve Gerçek Zamanlı Verimlilik Hesabı İçin Geri Besleme Sistemi Geliştirilmesi

      Directory of Open Access Journals (Sweden)

      Ersen KURU

      2016-01-01

      Full Text Available Geçmişte HVAC sistemlerinin altyapı ve teknik yeterliliklerinin konfigürasyonu sorundu. Gelişen mekanik, elektrik-elektronik ve bilgisayar teknolojisiyle bu sorunların yerini daha verimli nasıl kullanılabileceği sorusu yer almıştır. Bu tür sistemleri verimli kullanabilmemiz için de mutlaka somut ölçümler yapılmalıdır. Çünkü ölçemediğimiz durumları verimli yönetmemiz söz konusu olamaz. Bina enerji hesaplama yazılımları tasarım aşamasında fikir vermesi için oldukça büyük öneme sahiptir. Fakat geri besleme olarak herhangi bir somut ölçümsel denetim mekanizmaları bulunmamaktadır. Bina otomasyonu, özellikle de HVAC sistemlerinin verimlilik düzeylerinin denetlenmesi için mutlaka geri beslemesi bulunan sistemlerden bilgi alınması gerekmektedir.  Bu çalışmada mevcut HVAC otomasyon sistemlerinin enerji verimlilikleri güvenilirlik düzeyleri ve denetim mekanizmalarının güçlendirilmesi için yapılması gereken geri besleme sistemleri hakkında çalışmalar yapılmıştır.

    9. Teaching the concept of dispersion by diffraction of light to elementary school students

      Science.gov (United States)

      Resnick, J.; Monroy-Ramírez, F. A.

      2017-08-01

      This paper discusses the development and implementation of a practice based on Active Learning Methodology (ALM) with the aim of encouraging students from an early age to be interested in the world of science. The practical proposal is registered in the area of physics, especially in the field of wave optics, since it turns out to be very attractive to all ages especially for children. This didactic sequence was developed with students from elementary school. The experimental sequence developed is composed by several experimental activities allowing to observe and describe the phenomenon of diffraction scattering, from the entering of light through a piece of compact disc (CD) which acts as a diffraction grating. The distance between the diffraction grating and the screen on which the maximum intensity markers are projected remains constant throughout the practice. Children light up the CD with a red pointer, mark on the screen the position of the different maximum intensity markers, then repeat with the green pointer and finally with blue; from observation and the answer of guiding questions proposed by the teacher, they begin to draw conclusions to diffraction for each wavelength. In this way, the child observes that the maximum intensity markers (diffraction orders) associated with each color are located in different positions. Later, children are enquired about the result of the process when it is repeated with white light. Immediately afterwards, the experiment is tried with white light to check it. Finally, comparing the results observed with pointers in different colors with the result out of the practice with white light, a relevant discussion starts, bringing students to the concept of diffraction scattering. An important aspect is that the materials used in this experiment represents an important advantage in their application, since they are easily accessible (except for laser pointers in colors that are not very common in some places), so it is a

    10. Forecasting Zakat collection using artificial neural network

      Science.gov (United States)

      Sy Ahmad Ubaidillah, Sh. Hafizah; Sallehuddin, Roselina

      2013-04-01

      'Zakat', "that which purifies" or "alms", is the giving of a fixed portion of one's wealth to charity, generally to the poor and needy. It is one of the five pillars of Islam, and must be paid by all practicing Muslims who have the financial means (nisab). 'Nisab' is the minimum level to determine whether there is a 'zakat' to be paid on the assets. Today, in most Muslim countries, 'zakat' is collected through a decentralized and voluntary system. Under this voluntary system, 'zakat' committees are established, which are tasked with the collection and distribution of 'zakat' funds. 'Zakat' promotes a more equitable redistribution of wealth, and fosters a sense of solidarity amongst members of the 'Ummah'. The Malaysian government has established a 'zakat' center at every state to facilitate the management of 'zakat'. The center has to have a good 'zakat' management system to effectively execute its functions especially in the collection and distribution of 'zakat'. Therefore, a good forecasting model is needed. The purpose of this study is to develop a forecasting model for Pusat Zakat Pahang (PZP) to predict the total amount of collection from 'zakat' of assets more precisely. In this study, two different Artificial Neural Network (ANN) models using two different learning algorithms are developed; Back Propagation (BP) and Levenberg-Marquardt (LM). Both models are developed and compared in terms of their accuracy performance. The best model is determined based on the lowest mean square error and the highest correlations values. Based on the results obtained from the study, BP neural network is recommended as the forecasting model to forecast the collection from 'zakat' of assets for PZP.

    11. Der terminus προνοητησ in der Byzantinischen verwaltung

      Directory of Open Access Journals (Sweden)

      Wassiliou-Seibt Alexandra-Kyriaki

      2013-01-01

      Full Text Available The article examines on the basis of the small number of essential literary and sigillographic evidence the scope and duties of the προνοηταí (as a terminus technicus in the Byzantine administration. The earliest evidence comes from the 6th century, the latest from the 12th. Already in the Early Byzantine period the scope of their activities is fixed: administration of domains and municipal and fiscal administration. Acting in the capacity of stewards of private and official real estate these people were responsible for collecting and transmitting taxes to the responsible department, minus an allowance for themselves. Their colleagues in the municipal and provincial administration were revenue officers with special authority. In the provincial administration of the 11th the pronoetai were sometimes also άναγραφείς in their region. Till now we know only one example of a commander of a thema who was at the same time also a προνοητής (Eustathios Charsianites. The προνοηταί τού δημοσίου (scil. fiscus were authorized to exact outstanding taxes. A special case is the προνοητής of the alms-house of Michael Attaleiates in Rhaidestos, because he was the highest administrator of all its estates and dependencies. Normally the προνοηταί were administrators of a lower rank in the domains, subject to the οίκονόμος or the κουράτωρ.

    12. Simulation and Optimization of Vacuum Swing Adsorption Units for Spacesuit Carbon Dioxide and Humidity Control

      Science.gov (United States)

      Swickrath, Michael J.; Anderson, Molly; McMillin, Summer; Broerman, Craig

      2011-01-01

      Controlling carbon dioxide (CO2) and humidity levels in a spacesuit is critical to ensuring both the safety and comfort of an astronaut during extra-vehicular activity (EVA). Traditionally, this has been accomplished utilizing either non-regenerative lithium hydroxide (LiOH) or regenerative but heavy metal oxide (MetOx) canisters which pose a significant weight burden. Although such technology enables air revitalization, the volume requirements to store the waste canisters as well as the mass to transport multiple units become prohibitive as mission durations increase. Consequently, motivation exists toward developing a fully regenerative technology for spacesuit environmental control. The application of solid amine materials with vacuum swing adsorption technology has shown the capacity to control CO2 while concomitantly managing humidity levels through a fully regenerative cycle eliminating constraints imposed with the traditional technologies. Prototype air revitalization units employing this technology have been fabricated in both a rectangular and cylindrical geometry. Experimental results for these test articles have been collected and are described herein. In order to accelerate the developmental efforts, an axially-dispersed plug flow model with an accompanying energy balance has been established and correlated with the experimental data. The experimental and simulation results display good agreement for a variety of flow rates (110-170 ALM), replicated metabolic challenges (100-590 Watts), and atmosphere pressures under consideration for the spacesuit (248 and 760 mm Hg). The testing and model results lend insight into the operational capabilities of these devices as well as the influence the geometry of the device has on performance. In addition, variable metabolic profiles were imposed on the test articles in order to assess the ability of the technology to transition to new metabolic conditions. The advent of the model provides the capacity to apply

    13. The influence of the geomorphological factors on the relief modelling within Eselnita hydrographic basin (Danube catchment/Romania

      Directory of Open Access Journals (Sweden)

      DANIELA VLAD

      2012-08-01

      Full Text Available Developed on the south-eastern side of Almãjului Mountains, Eşelniţa drainage basin neighbours upon the following basins: upon S – SV with Mala, upon SV - V with Mraconia, upon V – NV with Berzasca, upon NV - NNE with Nera and on the NNE – SE direction with Cerna. The basin has a surface of 77 km2 and present a 5th degree hydrographic network according to Horton-Strahler ranking system, tributary to Danube by means of Eşelniţa main collector. Developed in a mountain landscape, the basin presents different levels held between minimum altitude of 64 m at the confluence with the Danube and maximum altitude of 1107 m, thus presenting a difference of 1043 m. Geological formations within the basin belong predominant to the Danubian Domain, so in central and upper courses, these are represented by a crystalline foundation and by magmatic rocks of intrusive nature covered by very small areas of sediment located in the northwest (belong to the Lower Jurassic and in the south-eastern (belongs to the Upper Cretaceous of the basin. But in the lower course, there are both crystalline and the sedimentary formations, last being integrated to Orşova depression and whose presence is related to the evolution of the Danube. Morphometric indices of Eşelniţa basin allows the distinction of a higher sector, mountainous terrain with high energy under a relatively increased fragmentation and depression sector with low relief energy and also with an intense fragmentation of the existing sedimentary rocks wich favors erosion manifestation in the context of deforestation action.

    14. Zeytinyağı Üretiminde HACCP Uygulamasının Önemi ve Kazandıracakları

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      Gülgün Yıldız Tiryaki

      2015-02-01

      Full Text Available Uluslararası ticaretin gelişmesi, tüketicinin bilinçlenmesi, gıda ürünleri satın almada çeşitlilik ve farklılık taleplerinin yani sıra saflık ve çevre kaygısının artması, üreticilerin ve karar alıcıların konuya daha hassas ve bilinçli yaklaşmalarını sağlamıştır. Bu bağlamda, küreselleşen dünyada, HACCP uluslararası platformda kabul görmüş, bilimsel temele dayalı önleyici bir sistem olarak gıda güvenirliliğinde yerini almıştır. Bu itibarla, uluslararası mevzuatlara uyum sağlamak ve Türkiye'nin pazar payının arttırılması yönünden HACCP sistemi, işletmeler açısından giderek önem kazanmıştır. Bu çalışma ile, ülke ekonomisi açısından büyük önemi olan zeytinyağı üretiminde HACCP uygulamasının önemi ve kazandırdıkları ele alınacaktır.

    15. Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma

      Directory of Open Access Journals (Sweden)

      Paula González-Alonso

      2015-08-01

      Full Text Available Mutations in Human Epidermal Growth Factor Receptors (HER are associated with poor prognosis of several types of solid tumors. Although HER-mutation detection methods are currently available, such as Next-Generation Sequencing (NGS, alternative pyrosequencing allow the rapid characterization of specific mutations. We developed specific PCR-based pyrosequencing assays for identification of most prevalent HER2 and HER3 mutations, including S310F/Y, R678Q, L755M/P/S/W, V777A/L/M, 774-776 insertion, and V842I mutations in HER2, as well as M91I, V104M/L, D297N/V/Y, and E332E/K mutations in HER3. We tested 85 Formalin Fixed and Paraffin Embbeded (FFPE samples and we detected three HER2-V842I mutations in colorectal carcinoma (CRC, ovarian carcinoma, and pancreatic carcinoma patients, respectively, and a HER2-L755M mutation in a CRC specimen. We also determined the presence of a HER3-E332K mutation in an urothelial carcinoma sample, and two HER3-D297Y mutations, in both gastric adenocarcinoma and CRC specimens. The D297Y mutation was previously detected in breast and gastric tumors, but not in CRC. Moreover, we found a not-previously-described HER3-E332E synonymous mutation in a retroperitoneal leiomyosarcoma patient. The pyrosequencing assays presented here allow the detection and characterization of specific HER2 and HER3 mutations. These pyrosequencing assays might be implemented in routine diagnosis for molecular characterization of HER2/HER3 receptors as an alternative to complex NGS approaches.

    16. A study of the volatilization-excitation phenomena affecting to the efficiency of spectrochemical buffers applied to uranium ore analysis

      International Nuclear Information System (INIS)

      Diaz-Guerra Gonzalez, J.P.

      1977-01-01

      A direct-current arc emission spectroscopy method allowing the determination of Alm Ca, Fe, Mg, Mn, Na, P, Si and Ti in uranium ores and geological materials has been developed by studying the efficiency of Ag 2 O, BaCO 3 , Bi 2 O 3 , CuF 2 , CuO, Ga 2 O 3 , GeO 2 , graphite, K 2 CO 3 , Li 2 B 4 O 7 , Li 2 CO 3 , Ni, PbS, Sb 2 O 4 , SrCO 3 , Tl 2 O 3 and ZnO as spectrochemical buffers. Volatilization-excitation mechanisms of Li 2 CO 3 : graphite, GeO 2 : graphite and SrCO 3 : graphite buffer mixtures have been specially considered. Procedures to investigate phenomena taking place in the electrode, anodic load and arc plasma have been selected. Intensity-time curves; voltage variation between electrodes; vapour diffussion through the electrode walls; load depletion; reaction products formation and temperature, electron pressure and ionization degree in the arc plasma have been studied. Measurements of plasma parameters are performed by introducing thermometric and manometric species in both the anode and the cathode electrodes. The effects of different alkalin matrices on transportation phenomena are also considered. Emission efficiency of some analytical lines has been investigated by the application of a mathematical model enclosing fundamental parameters of the arc plasma. Efficiency of scattered primary X-rays of various wavelengths has been studied as a correction of matrix effects in the uranium determination. Results illustrate that the incoherently-scattered MoKβsub(1,3) radiation is the optimum reference line. (author)

    17. The "Frontier" And Frontier Guards in Banat - a Socio- Historical Approach

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      SEBASTIAN ŞTEFĂNUCĂ

      2010-06-01

      Full Text Available The researchers preoccupied with the regional identity potential of Ţara Almăjului and the Eastern area of the Banat mountain region, Romania, cannot avoid the particular historical evolution, in the last three centuries, of these regions. This is true precisely when the starting point is represented by the Wealth Community (Comunitatea de Avere - a form of collective ownership of a large part of the forests in the abovementioned regions and of certain buildings - a direct remnant of the Austrian frontier past, which was abolished during the Communist period. At that time (the second half of the 18th century, this form of collective ownership generated deep and irreversible social, administrative, architectural, legal and economic transformations which are visible to this day. Apart from an elite preoccupied with historical studies, in relation to which we notice the open affirmation of identity valences which we look for, and apart from another elite which is interested in reinstating and managing the Wealth Community, the locals seem detached both from the past and the frontier, as well as from the attempts to reinstate the Wealth Community. The only truly relevant form of ownership is individual ownership. We consider that this attitude is a variant of what Lucian Blaga called a "boycott of history". Therefore, the identity looked for seems to be constituted not so much by opposing, than by ignoring the past and the disinterest towards collective ownership, to which we can add the suspicion with respect to the intentions of people holding positions within the local administration and state authorities generally.

    18. Analysis of lines and breeds of sires in the breeding of the Czech warmblood horses based on grading their offspring in rearing facilities for testing young horses (RFT

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      Hana Černohorská

      2013-01-01

      Full Text Available The objective of the present study was to evaluate the effect of the breed of sire and line of sire on grading of the body conformation and performance of colts of warmblood horses in rearing facilities for testing young horses (RFT. The groundwork database contained data from 2001 to 2011 from nine RFT’s. The database was processed statistically using the GLM method to assess the statistical significance of the effect of the breed of the sire and line of the sire on body conformation and performance of the colts. By multiple comparisons of the individual effects using the Tukey-B method we discovered statistically significant differences in the body conformation and performance of colts of sires among the respective breeds and lines. The performance of the offspring of Dutch warmblood, Hanoverian horse and Holsteiner horse sires is better than of the offspring of sires of the Thoroughbred, Czech warmblood and Selle Francais. The conformation of the offspring by sires of the Holsteiner horse and Hanoverian horse breeds is superior to that of offspring by sires of the Selle Francais and Czech warmblood. The mechanics of movement of the offspring of the 2300 Shagya XVIII-Báb. line is inferior to the offspring of the following lines: 3100 Adeptus xx, 67 Dark Ronald, 1000 Der Lowe xx, 3250 Dwinger 3257, 4800 Ladykiller xx, Orange Peel xx – Alme Z, 1100 Przedswit VI-Rad., 4900 Rantzau xx – Cor De La Bryere, 4600 Rittersporn xx – Ramzes 4028, 60 St. Simon and 88 Teddy. The effect of the line of the sires on the body conformation of colts has not been proved.

    19. Textural and chemical evolution of pyroxene during hydration and deformation: A consequence of retrograde metamorphism

      Science.gov (United States)

      Centrella, Stephen; Putnis, Andrew; Lanari, Pierre; Austrheim, Håkon

      2018-01-01

      Centimetre-sized grains of Al-rich clinopyroxene within the granulitic anorthosites of the Bergen Arcs, W-Norway undergo deformation by faults and micro-shear zones (kinks) along which fluid has been introduced. The clinopyroxene (11 wt% Al2O3) reacts to the deformation and hydration in two different ways: reaction to garnet (Alm41Prp32Grs21) plus a less aluminous pyroxene (3 wt% Al2O3) along kinks and the replacement of the Al-rich clinopyroxene by chlorite along cleavage planes. These reactions only take place in the hydrated part of a hand specimen that is separated from dry, unreacted granulite by a sharp interface that defines the limit of hydration. We use electron probe microanalysis (EPMA) and X-Ray mapping together with electron backscatter diffraction (EBSD) mapping to investigate the spatial and possible temporal relationships between these two parageneses. Gresens' analysis (Gresens, 1967) has been used to determine the mass balance and the local volume changes associated with the two reactions. The reaction to garnet + low-Al clinopyroxene induces a loss in volume of the solid phases whereas the chlorite formation gains volume. Strain variations result in local variation in undulose extinction in the parent clinopyroxene. EBSD results suggest that the density-increasing reaction to garnet + low-Al clinopyroxene takes place where the strain is highest whereas the density-decreasing reaction to chlorite forms away from shear zones where EBSD shows no significant strain. Modelling of phase equilibria suggest that the thermodynamic pressure of the assemblage within the shear zones is > 6 kbar higher than the pressure conditions for the whole rock for the same range of temperature ( 650 °C). This result suggests that the stress redistribution within a rock may play a role in determining the reactions that take place during retrograde metamorphism.

    20. Article-level metrics and the periphery: an exploration of articles by Brazilian authors

      Energy Technology Data Exchange (ETDEWEB)

      Souza, I.V.P.; Gouveia, F.C.

      2016-07-01

      This work-in-progress paper describes an ongoing PhD study that aims to explore article-level metrics from a set of articles published by Brazilian researchers. It is argued that article-level metrics can offer a more nuanced and accurate picture of the influence of a particular work in comparison to journal-level metrics. However, if these new metrics rely on sources that exclude a large part of research from the periphery, they are at risk of simply preserving the present inequalities in the scholarly communication system. In order to understand how article-level metrics are or could be useful to the scientific community in the peripheries, we need to see what metrics are currently available, identify possible biases, and understand their meaning. We aim to contribute to this discussion with a case study focused on exploring a set of both traditional and alternative article-level metrics related to publications authored by Brazilian researchers. So far, few studies analyse article-level metrics for Brazilian publications, and most focus on Brazilian journals instead of researcher's affiliation. Our study will collect articles with DOIs registered by Brazilian researchers at the Lattes Platform, an information system maintained by the national Science, Technologies and Communications ministry. This exploration aims to address the following questions: (a) Which are the main article-level metrics available for journal articles authored by Brazilian researchers? What are the main sources of ALM data for Brazilian publications?; (b) Are there any disciplines, institutions, locations etc. that attract more mentions in the case of Brazilian articles? How do these metrics compare among themselves?; and (c) Do articlelevel metrics of publications by Brazilian researchers reflect patterns and trends observed in studies with researchers from other countries? (Author)

    1. AN INVESTIGATION OF JOB AND CAREER COUNSELING CANDIDATES FROM THE PERSPECTIVE OF DIVERSITY MANAGEMENT (İŞ VE MESLEK DANIŞMANLIĞI ADAYLARININ FARKLILIK YÖNETİMİ PERSPEKTİFİNDEN İNCELENMESİ

      Directory of Open Access Journals (Sweden)

      Serdar BOZKURT

      2013-10-01

      Full Text Available ABSTRACT: In this current study we are examining individuals who are trained for job and career counseling in terms of their ‘attitudes towards diversity’ ‘empathy skills’ and ‘potential for diversity management performance’. In this respect, the relationship between the ‘attitudes towards diversity’ and ‘empathy skills’ of career counselors, who will be working in the personnel selection and placement process, will be investigated. Furthermore, the impact of ‘attitudes towards diversity’ and ‘empathy skills’ on ‘potential for diversity management performance’ will be studied. The differentiating effect of gender on ‘empathy skills’ of individuals who are trained for job and career counseling will also be covered in the research context. The research is conducted on 266 future job and career counselors. Results reveals a positive relationship between ‘potential for diversity management performance’ and ‘empathy skills’ as well as between ‘attitudes towards diversity’ and ‘empathy skills’ of trained counselors. Furthermore, results points out that ‘empathy skills’ and ‘attitudes towards diversity’ significantly predicts ‘potential for diversity management performance’. Additionally a significant gender difference is found to exist in terms of ‘empathy skills’ of individuals. Keywords: Diversity, Diversity Management, Diversity Management Performance, Empathy Skills, Job and Career Counselors, Job and Career Counseling. ÖZ: Çalışmada, iş ve meslek danışmanlığı eğitimi almış kişilerin, işgücündeki farklılıklara ilişkin tutumları, empati becerileri ve farklılıkların yönetimine yönelik potansiyel performansları araştırılmaktadır. Personel seçimi ve yerleştirilmesi ile kariyer danışmanlığı süreçlerinde çalışacak bireylerin, farklılıklara ilişkin tutumları ile empati becerileri arasında ilişki olup olmadığı ve farklılıklara y

    2. Adaptation response surfaces from an ensemble of wheat projections under climate change in Europe

      Science.gov (United States)

      Ruiz-Ramos, Margarita; Ferrise, Roberto

      2016-04-01

      preliminary ARSs show some adaptation options allow recover up to ca. 2000 kg/ha. Compared to the historical yields recorded at Lleida province (2550 kg/ha in 1981-2010) our results indicate that adaptation is feasible and may help to reduce detrimental effects of CC. Our analysis evaluates if the explored adaptations fulfill the biophysical requirements to become a practical adaptive solution. This study exemplifies how adaptation options and their impacts can be analyzed, evaluated and communicated in a context of high regional uncertainty for current and future conditions and for short to long-term perspective. This work was funded by MACSUR project within FACCE-JPI. References Abeledo, L.G., R. Savin and G.A. Slafer (2008). European Journal of Agronomy 28:541-550. Cartelle, J., A. Pedró, R. Savin, G.A. Slafer (2006) European Journal of Agronomy 25:365-371. Pirttioja, N., T. Carter, S. Fronzek, M. Bindi, H. Hoffmann, T. Palosuo, M. Ruiz-Ramos, F. Tao, M. Acutis, S. Asseng, P. Baranowski, B. Basso, P. Bodin, S. Buis, D. Cammarano, P. Deligios, M.-F. Destain, B. Dumont, R. Ewert, R. Ferrise, L. François, T. Gaiser, P. Hlavinka, I. Jacquemin, K.C. Kersebaum, C. Kollas, J. Krzyszczak, I.J. Lorite, J. Minet, M.I. Minguez, M. Montesino, M. Moriondo, C. Müller, C. Nendel, I. Öztürk, A. Perego, A. Rodríguez, A.C. Ruane, F. Ruget, M. Sanna, M.A. Semenov, C. Slawinski, P. Stratonovitch, I. Supit, K. Waha, E. Wang, L. Wu, Z. Zhao, and R.P. Rötter, 2015: A crop model ensemble analysis of temperature and precipitation effects on wheat yield across a European transect using impact response surfaces. Clim. Res., 65, 87-105, doi:10.3354/cr01322. IRS2 TEAM: Alfredo Rodríguez(1), Ignacio J. Lorite(3), Fulu Tao(4), Nina Pirttioja(5), Stefan Fronzek(5), Taru Palosuo(4), Timothy R. Carter(5), Marco Bindi(2), Jukka G Höhn(4), Kurt Christian Kersebaum(6), Miroslav Trnka(7,8), Holger Hoffmann(9), Piotr Baranowski(10), Samuel Buis(11), Davide Cammarano(12), Yi Chen(13,4), Paola Deligios

    3. EDITORIAL: 'Best article' prize for the 5th anniversary of Environmental Research Letters 'Best article' prize for the 5th anniversary of Environmental Research Letters

      Science.gov (United States)

      Kammen, Dan; Wright, Guillaume

      2011-12-01

      To celebrate the 5th anniversary of Environmental Research Letters (ERL) the publishers of the journal, IOP Publishing, have awarded a prize for the five best articles published in ERL since the journal began in 2006. The procedure for deciding the winning articles was as thorough as possible to ensure that the most outstanding articles would win the prize. A shortlist of 25 nominated research articles, five for each year since ERL was launched, which were chosen based on a range of criteria including novelty, scientific impact, readership, broad appeal and wider media coverage, was selected. The ERL Editorial Board then assessed and rated these 25 articles in order to choose a winning article for each year. We would like to announce that the following articles have been awarded ERL's 5th anniversary best article prize: 2006/7 The Bodélé depression: a single spot in the Sahara that provides most of the mineral dust to the Amazon forest Ilan Koren, Yoram J Kaufman, Richard Washington, Martin C Todd, Yinon Rudich, J Vanderlei Martins and Daniel Rosenfeld 2006 Environ. Res. Lett. 1 014005 2008 Causes and impacts of the 2005 Amazon drought Ning Zeng, Jin-Ho Yoon, Jose A Marengo, Ajit Subramaniam, Carlos A Nobre, Annarita Mariotti and J David Neelin 2008 Environ. Res. Lett. 3 014002 2009 How difficult is it to recover from dangerous levels of global warming? J A Lowe, C Huntingford, S C B Raper, C D Jones, S K Liddicoat and L K Gohar 2009 Environ. Res. Lett. 4 014012 2010 Is physical water scarcity a new phenomenon? Global assessment of water shortage over the last two millennia Matti Kummu, Philip J Ward, Hans de Moel and Olli Varis 2010 Environ. Res. Lett. 5 034006 2011 Implications of urban structure on carbon consumption in metropolitan areas Jukka Heinonen and Seppo Junnila 2011 Environ. Res. Lett. 6 014018 Our congratulations go to these authors. In recognition of their outstanding work, we are delighted to offer all of the authors of the winning articles free

    4. Influence of plant productivity over variability of soil respiration: a multi-scale approach

      Science.gov (United States)

      Curiel Yuste, J.

      2009-04-01

      general controlled by the seasonality of substrate supply by plants (via photosynthates translocation and/or litter) to soil. Although soil temperature and soil moisture exert a strong influence over the variation in SR, our results indicates that substrate supply by plant activity could exert a more important than previously expected role in the variability of soil respiration. 1. CREAF (Centre de Recerca Ecológica i Aplicacions Forestals), Unitat d'Ecofisiologia i Canvi Global CREAF-CEAB-CSIC, BELLATERRA (Barcelona), Spain (j.curiel@creaf.uab.es) 2. University of Antwerp (UA), Antwerp, Belgium (ivan.janssens@ua.ac.be) 3. Institute of Ecology, University of Innsbruck, Innsbruck, Austria (michael.bahn@uibk.ac.at) 4. UMR Ecologie et Ecophysiologie Forestières, Centre INRA de Nancy, France (longdoz@nancy.inra.fr) 5. ESPM, University of Calicornia at Berkeley, Berkeley, CA, US (baldocchi@nature.berkeley.edu) 6. The Woods Hole Research Center, Falmouth, USA (edavidson@whrc.org) 7. Max-Planck-Institute for Biogeochemistry, Jena, Germany (markus.reichstein@bgc-jena.mpg.de) 8. Institute of Systems Biology and Ecology, Academy of Sciences of the Czech Republic, Czech Republic (manuel@brno.cas.cz) 9. Università degli studi della Tuscia, Viterbo, Italy (arriga@unitus.it) 10. Laurence Berkeley lab, Berkeley, CA, USA (mstorn@lbl.gov) 11. Gembloux Agricultural University, Gembloux, Belgium (aubinet.m@fsagx.ac.be) 12. Fundacion CEAM(Centro de Estudios Ambientales del Mediterráneo), Valencia, Spain (arnaud@ceam.es) 13. Institute of Hydrology and Meteorology, Technische Universität Dresden, Pienner, Germany (gruenwald@forst.tu-dresden.de) 14. Department of Environmental Sciences, Second University of Naples, Caserta, Italy (ilaria.inglima@unina2.it) 15. CNRS-CEFE Montpellier, France (Laurent.MISSON@cefe.cnrs.fr) 16. Agenzia Provinciale per l'Ambiente, Bolzano, Italy (leonar@inwind.it) 17. University of Helsinki Department of Forest Ecology, Helsinki, Finland (jukka

    5. Book Reviews

      Directory of Open Access Journals (Sweden)

      F.J.M. Selier

      1985-01-01

      Full Text Available - M.A. van Bakel, H. Esen-Baur, Untersuchungen über den vogelmann-kult auf der Osterinsel, 1983, Franz Steiner Verlag GmbH, 399 pp. - Leen Boer, Bronislaw Malinowski, Malinowski in Mexico. The economics of a Mexican market system, edited and with an introduction by Susan Drucker-Brown, London: Routledge and Kegan Paul, 1982 (International Library of Anthropology., Julio de la Fuente (eds. - A.P. Borsboom, Betty Meehan, Shell bed to shell midden, Australian Institute of Aboriginal Studies, Canberra, 1982. - H.J.M. Claessen, Peter Geschiere, Village communities and the state. Changing relations among the Maka of Southeastern Cameroon since the colonial conquest. Monographs of the African Studies Centre, Leiden. London: Routledge and Kegan Paul Ltd. 1982. 512 pp. Appendices, index, bibliography, etc. - H.J.M. Claessen, Jukka Siikala, Cult and conflict in tropical Polynesia; A study of traditional religion, Christianity and Nativistic movements, Helsinki: Academia Scientiarum Fennica, 1982, 308 pp. Maps, figs., bibliography. - H.J.M. Claessen, Alain Testart, Les Chasseurs-Cueilleurs ou l’Origine des Inégalités, Mémoires de la Sociéte d’Ethnographie 26, Paris 1982. 254 pp., maps, bibliography and figures. - Walter Dostal, Frederik Barth, Sohar - Culture and society in an Omani town. Baltimore - London: The Johns Hopkins University Press, 1983, 264 pp., ill. - Benno Galjart, G.J. Kruyer, Bevrijdingswetenschap. Een partijdige visie op de Derde Wereld [Emancipatory Science. A partisan view of the Third World], Meppel: Boom, 1983. - Sjaak van der Geest, Christine Okali, Cocoa and kinship in Ghana: The matrilineal Akan of Ghana. London: Kegan Paul International (in association with the International African Institute, 1983. 179 pp., tables, index. - Serge Genest, Claude Tardits, Contribution de la recherche ethnologique à l’histoire des civilisations du Cameroun / The contribution of enthnological research to the history of Cameroun cultures

    6. Neuropathic pain: transcranial electric motor cortex stimulation using high frequency random noise. Case report of a novel treatment

      Directory of Open Access Journals (Sweden)

      Alm PA

      2013-06-01

      Full Text Available Per A Alm, Karolina DreimanisDepartment of Neuroscience, Uppsala University, Uppsala, SwedenObjectives: Electric motor cortex stimulation has been reported to be effective for many cases of neuropathic pain, in the form of epidural stimulation or transcranial direct current stimulation (tDCS. A novel technique is transcranial random noise stimulation (tRNS, which increases the cortical excitability irrespective of the orientation of the current. The aim of this study was to investigate the effect of tRNS on neuropathic pain in a small number of subjects, and in a case study explore the effects of different stimulation parameters and the long-term stability of treatment effects.Methods: The study was divided into three phases: (1 a double-blind 100–600 Hz, varying from 0.5 to 10 minutes and from 50 to 1500 µA, at intervals ranging from daily to fortnightly.crossover study, with four subjects; (2 a double-blind extended case study with one responder; and (3 open continued treatment. The motor cortex stimulation consisted of alternating current random noise (100–600 Hz, varying from 0.5 to 10 minutes and from 50 to 1500 μA, at intervals ranging from daily to fortnightly.Results: One out of four participants showed a strong positive effect (also compared with direct-current-sham, P = 0.006. Unexpectedly, this effect was shown to occur also for very weak (100 µA, P = 0.048 and brief (0.5 minutes, P = 0.028 stimulation. The effect was largest during the first month, but remained at a highly motivating level for the patient after 6 months.Discussion: The study suggests that tRNS may be an effective treatment for some cases of neuropathic pain. An important result was the indication that even low levels of stimulation may have substantial effects.Keywords: neuropathic pain, central pain, transcranial direct current stimulation, motor cortex stimulation, random noise stimulation

    7. Sarcopenia Screened by the SARC-F Questionnaire and Physical Performances of Elderly Women: A Cross-Sectional Study.

      Science.gov (United States)

      Rolland, Yves; Dupuy, Charlotte; Abellan Van Kan, Gabor; Cesari, Matteo; Vellas, Bruno; Faruch, Marie; Dray, Cedric; de Souto Barreto, Philipe

      2017-10-01

      Screening for sarcopenia in daily practice can be challenging. Our objective was to explore whether the SARC-F questionnaire is a valid screening tool for sarcopenia (defined by the Foundation for the National Institutes of Health [FNIH] criteria). Moreover, we evaluated the physical performance of older women according to the SARC-F questionnaire. Cross-sectional study. Data from the Toulouse and Lyon EPIDémiologie de l'OStéoporose study (EPIDOS) on 3025 women living in the community (mean age: 80.5 ± 3.9 years), without a previous history of hip fracture, were assessed. The SARC-F self-report questionnaire score ranges from 0 to 10: a score ≥4 defines sarcopenia. The FNIH criteria uses handgrip strength (GS) and appendicular lean mass (ALM; assessed by DXA) divided by body mass index (BMI) to define sarcopenia. Outcome measures were the following performance-based tests: knee-extension strength, 6-m gait speed, and a repeated chair-stand test. The associations of sarcopenia with performance-based tests was examined using bootstrap multiple linear-regression models; adjusted R 2 determined the percentage variation for each outcome explained by the model. Prevalence of sarcopenia was 16.7% (n = 504) according to the SARC-F questionnaire and 1.8% (n = 49) using the FNIH criteria. Sensibility and specificity of the SARC-F to diagnose sarcopenia (defined by FNIH criteria) were 34% and 85%, respectively. Sarcopenic women defined by SARC-F had significantly lower physical performance than nonsarcopenic women. The SARC-F improved the ability to predict poor physical performance. The validity of the SARC-F questionnaire to screen for sarcopenia, when compared with the FNIH criteria, was limited. However, sarcopenia defined by the SARC-F questionnaire substantially improved the predictive value of clinical characteristics of patients to predict poor physical performance. Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine

    8. Nar Suyunun Durultma İşlemi ve Depolama Süresince Meydana Gelen Değişmeler Üzerinde Araştırmalar

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      Dilsun Tabur

      2015-02-01

      Full Text Available İzmir ilinde yetiştirilen tatlı çeşitteki narlar araştırmada kullanılmıştır. Nar suyuna iki farklı durultma denemesi uygulanmış ve uygun olan enzim jelatin kombinasyonu ile durultulmuş nar suları 85 oC de 25 dakika pastörize edilip soğuk ve normal koşullarda depolanmışlardır. İşleme aşamalarında renk intensiteleri 740-300/abxlo3 -540 nm/arasında ve ortalama 540 bulunmuştur. Değişen antosiyanin değerlerine durultma ve ısısal işlemin etki ederek azalmalara neden olduğu ve artan presyon ile bu değerin azaldığı bulgulanmıştır. İşlemin ara aşamalarının suda çözünür kuru madde içeriğine etki etmediği bulunmuştur. Tadı etkileyen tanen niceliği 85-103 mg/l arasında ve ortalama 94.5 mg/l olarak saptanmıştır. Duyusal analizlerde en yüksek puanı tat almış renk ve koku arasında belirgin bir kalite puanlaması farkına varılmamıştır. Araştırmada nar sularının stabilizasyonu için depektinasyon jelatin kombinasyonu uygun sonuçlar verdiği görülmüştür. Bu durultma yöntemi ile tanen niceliğinin yüksek kalması bazı tüketici isteklerini de karşılamaktadır. Depolama süresince depolama sıcaklığının kalitenin ve rengin korunmasında etkili olduğu saptanılmıştır.

    9. Validation of two portable bioelectrical impedance analyses for the assessment of body composition in school age children.

      Directory of Open Access Journals (Sweden)

      Li-Wen Lee

      Full Text Available Bioelectrical impedance analysis (BIA is a convenient and child-friendly method for longitudinal analysis of changes in body composition. However, most validation studies of BIA have been performed on adult Caucasians. The present cross-sectional study investigated the validity of two portable BIA devices, the Inbody 230 (BIA8MF and the Tanita BC-418 (BIA8SF, in healthy Taiwanese children.Children aged 7-12 years (72 boys and 78 girls were recruited. Body composition was measured by the BIA8SF and the BIA8MF. Dual X-ray absorptiometry (DXA was used as the reference method.There were strong linear correlations in body composition measurements between the BIA8SF and DXA and between the BIA8MF and DXA. Both BIAs underestimated fat mass (FM and percentage body fat (%BF relative to DXA in both genders The degree of agreement in lean body mass (LBM, FM, and %BF estimates was higher between BIA8MF and DXA than between BIA8SF and DXA. The Lin's concordance correlation coefficient (ρc for LBM8MF met the criteria of substantial to perfect agreement whereas the ρc for FM8MF met the criteria of fair to substantial agreement. Bland-Altman analysis showed a clinically acceptable agreement between LBM measures by BIA8MF and DXA. The limit of agreement in %BF estimation by BIA and DXA were wide and the errors were clinically important. For the estimation of ALM, BIA8SF and BIA8MF both provided poor accuracy.For all children, LBM measures were precise and accurate using the BIA8MF whereas clinically significant errors occurred in FM and %BF estimates. Both BIAs underestimated FM and %BF in children. Thus, the body composition results obtained using the inbuilt equations of the BIA8SF and BIA8MF should be interpreted with caution, and high quality validation studies for specific subgroups of children are required prior to field research.

    10. Anastomose cavo-pulmonar total sem uso de material protético

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      Valdester C. PINTO Jr.

      1998-07-01

      Full Text Available Objetivo: Demonstrar a viabilidade na feitura de túnel cava inferior-cava superior com retalho da parede atrial direita, evitando o emprego de material protético. Casuística e Métodos: Foram operados 2 pacientes nos quais se empregou a técnica de anastomose cavo-pulmonar total, sem uso de material protético. O primeiro caso, A.L.M., masc, 4 anos, 15 kg, era portador de atresia tricúspide (EP, com comunicação interventricular (CIV restritiva. O segundo caso, M.E.N.O., fem, 15 anos, 47 kg, tinha doença de Ebstein. O controle pós-operatório dos pacientes foi feito com ecocardiograma e cateterismo cardíaco. As operações foram realizadas com o emprego de circulação extracorpórea (CEC, e cardioplegia sangüínea como método de proteção miocárdica. A canulação das cavas foi o mais distal possível. A tunelização foi realizada com retalho de tecido atrial direito, suturado ao septo interatrial, deixando-se o seio coronariano e a comunicação interatrial (CIA para a esquerda. Resultados: Ambos os pacientes evoluíram, sem complicações, na UTI. O primeiro apresentou derrame pleural discreto à direita, e o segundo mantém-se em estimulação artificial (VVI,R. Conclusões: A tunelização intra-atrial para anastomose cavo-pulmonar total pode ser realizada sem o uso de material protético, evitando-se os riscos advindos do seu emprego (calcificação, retração, embolização.The authors describe two cases (one tricuspid atresia without TGA or pulmonary stenosis, but with a restrictive IVC: the second of an Ebstein disease of total cavo-pulmonary anastomosis using only the tissue of the atrial wall, avoiding any prosthetic material. Both cases were done under cardiopulmonary bypass and cold blood cardioplegia. A flap of the right atrial wall was used to re-direct the blood flow. Pleural effusion in one patient and complete AV block in the other were the complications found. They conclude that right intra-atrial tunneling for

    11. NMR spectroscopy and X-ray characterisation of cationic N-heteroaryl-pyridylamido Zr(IV) complexes: a further level of complexity for the elusive active species of pyridylamido olefin polymerisation catalysts.

      Science.gov (United States)

      Li, Gang; Zuccaccia, Cristiano; Tedesco, Consiglia; D'Auria, Ilaria; Macchioni, Alceo; Pellecchia, Claudio

      2014-01-03

      New [(N(-),N,N(-))ZrR2] dialkyl complexes (N(-),N,N(-)=pyrrolyl-pyridyl-amido or indolyl-pyridyl-amido; R=Me or CH2Ph) have been synthesised and tested as pre-catalysts for ethene and propene polymerisation in combination with different activators, such as B(C6F5)3, [Ph3C][B(C6F5)4], [HNMe2Ph][B(C6F5)4] or solid AlMe3-depleted methylaluminoxane (DMAO). Polyethylene (M(w)>2 MDa and M(w)/M(n)= 1.3-1.6) has been produced if pre-catalysts were activated with 1000 equivalents of DMAO (based on Al) [activity >1000 kg(PE)(mol([Zr]) h mol atm)(-1)] or by using a higher pre-catalyst concentration and a mixture of [HNPhMe2][B(C6F5)4] (1 equiv) and AliBu2H (60 equiv). In the case of propene polymerisation, activity has been observed only if pre-catalysts were treated with an excess of AliBu2H prior to addition of DMAO, which led to highly isotactic polypropylene ([mmmm]>95%). Neutral pre-catalysts and ion pairs derived from their activation have been characterised in solution by using advanced 1D and 2D NMR spectroscopy experiments. The detection and rationalisation of intercationic NOEs clearly showed the formation of dimeric species in which some pyrrolyl or indolyl π-electron density of one unit is engaged in stabilising the metal centre of the other unit, which relegates the counterions in the second coordination sphere. The solid-state structure of the dimeric indolyl-pyridyl-amidomethylzirconium derivative, determined by X-ray diffraction studies, points toward a weak Zr···η(3)-indolyl interaction. It can be hypothesised that the formation of dimeric cationic species hampers monomer coordination (especially of less reactive α-olefins) and that addition of AliBu2H is crucial to split the homodimers. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

    12. Familial Alström syndrome: a rare cause of bilateral progressive hearing loss

      Directory of Open Access Journals (Sweden)

      Fayez Bahmad Jr.

      2014-04-01

      Full Text Available Introdução: A Síndrome de Alstrom é uma doença muito rara, causada pela mutação no gene Obesidade infantil; ALMS1, que apresenta uma degeneração progressiva das funções sensoriais, resultando em de-Diabetes mellitus tipo 2; ficiências visuais e auditivas, além de distúrbios metabólicos como obesidade na infância, hipe-Retinite pigmentosa rinsulinemia e diabetes tipo II. Objetivo: Apresentar o perfil audiométrico de dois irmãos da mesma família afetados pela Síndrome de Alström. Método: Estudo prospectivo, analítico descritivo, os pacientes afetados foram submetidos a um questionário previamente testado, audiometria tonal e vocal seriadas, análise de emissões otoacústicas, e de respostas de potencial evocado auditivo de tronco encefálico, além de análise genético-molecular para comprovação diagnóstica. Resultados: Ambos os pacientes apresentaram perda auditiva bilateral com o início na infância e progressão lenta para perda auditiva neurosensorial severa no primeiro caso e, profunda, no segundo. As emissões otoacústicas estavam ausentes, e o potencial evocado auditivo de tronco encefálico estava normal em ambos os pacientes, bilateralmente. Conclusão: A Síndrome de Alström apresenta início precoce de perda auditiva neurossensorial, antes da adolescência, 10 a 20 anos para desenvolver perda auditiva severa a profunda. A lesão auditiva é essencialmente coclear, de acordo com os resultados dos testes de emissões otoacústicas e de potenciais evocados auditivos de tronco encefálico.

    13. Growth and sporulation of Metarhizium flavoviride var. Flavoviride on culture media and lighting regimes Crescimento e esporulação de Metarhizium flavoviride var. Flavoviride em meios de cultura e regimes de luz

      Directory of Open Access Journals (Sweden)

      Sideney Becker Onofre

      2001-09-01

      Full Text Available Entomopathogenic fungi from the genus Metarhizium are largely used for the biological control of agricultural pests by conidia spreading on the field. Although conidia production is well studied in M. anisopliae, only few research studies were done in M. flavoviride. The present work was carried out alming to evaluate the Mycelial growth and sporulation of the entomopathogenic fungus Metarhizium flavoviride var. flavoviride growing at 27 ± 2°C on Potato-dextrose-agar (PDA, Czapek-agar (CZP and a complete agar medium (CM under three lighting regimes, (continuous illumination, light/dark cycle and an black light/dark cycle were investigated. A completely randomized 3 × 3 (culture media × lighting regime factorial design with four replicates was used. The best mycelial growth and sporulation occurred on the PDA and CM media under continuous illumination (P Fungos entomopatogênicos do genêro Metarhizium são empregados no controle biológico de pragas agrícolas por meio da dispersão de seus conídios no campo. Embora a produção de conídios em M. anisopliae esteja bem estudada, poucas pesquisas a respeito existem na espécie M. flavoviride. O presente trabalho foi realizado para avaliar o efeito de três meios de cultura, batata-dextrose-ágar (BDA, Czapek-ágar (CZP e meio completo (MC, e três regimes de luminosidade, claro contínuo, alternância com luz do dia/escuro e luz negra/escuro, sobre o crescimento miceliano e esporulação do fungo entomopatogênico Metarhizium flavoviride var. flavoviride. O experimento foi realizado em câmara de incubação à temperatura de 27 ± 2°C. Empregou-se um delineamento experimental inteiramente casualizado, em arranjo fatorial 3°C 3 (meios de cultura e regime de luminosidade com quatro repetições. As melhores condições para o crescimento miceliano e esporulação foram conseguidas tanto no meio de cultura BDA como no MC quando combinados com o regime claro contínuo (P <= 0,05.

    14. Exploring the efficiency of the Tilburg Frailty Indicator: a review

      Directory of Open Access Journals (Sweden)

      Gobbens RJJ

      2017-10-01

      Full Text Available Robbert JJ Gobbens,1–3 Jos MGA Schols,4 Marcel ALM van Assen5,6 1Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Amsterdam, the Netherlands; 2Zonnehuisgroep Amstelland, Amstelveen, the Netherlands; 3Department of General Practice, University of Antwerp, Antwerp, Belgium; 4Department of Health Services Research and Department of Family Medicine, CAPHRI-Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands; 5Department of Methodology and Statistics, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, the Netherlands; 6Department of Sociology, Utrecht University, Utrecht, the Netherlands Abstract: Due to rapidly aging human populations, frailty has become an essential concept, as it identifies older people who have higher risk of adverse outcomes, such as disability, institutionalization, lower quality of life, and premature death. The Tilburg Frailty Indicator (TFI is a user-friendly questionnaire based on a multidimensional approach to frailty, assessing physical, psychologic, and social aspects of human functioning. This review aims to explore the efficiency of the TFI in assessing frailty as a means to carry out research into the antecedents and consequences of frailty, and its use both in daily practice and for future intervention studies. Using a multidimensional approach to frailty, in contexts where health care professionals or researchers may have no time to interview or examine the client, we recommend employing the TFI because there is robust evidence of its reliability and validity and it is easy and quick to administer. More studies are needed to establish whether the TFI is suitable for intervention studies not only in the community, but also for specific groups such as patients in the hospital or admitted to an emergency department. We conclude that it is important to not only determine the deficits that frail older people may

    15. LOCALIZATION AND THE ELEMENTS OF THE SEVENTEENTH-CENTURY SOCIAL LIFE IN SÂBIT’S DIVAN SÂBİT DİVANI’NDA MAHALLÎLEŞME VE 17. YÜZYIL SOSYAL HAYAT UNSURLARI

      Directory of Open Access Journals (Sweden)

      Yunus KAPLAN

      2009-08-01

      Full Text Available Throughout the history, artists created their art using the elements of their society such as customs, traditions, commodities, words and lifestyles. Like other artists, our divan poets were inspired by their society, and in their poetry they used plenty of the accepted materialistic and moral values of the society. Sabit, a poet who lived in the second-half of the seventeenth century, was no exception. He decorated his poems with various dreams, and his careful observations and analyses of daily life were masterfully reflected in his poetry.This study classifies the elements reflecting the social life of the seventeenth century in Sabit’s poems. The relevant examples from Sabit’s Divan are also given. Tarihin her devrinde sanatkârlar, sanat eserlerini oluştururken mensup oldukları toplumun sosyal hayat tarzına ait yaşayış şekli, âdet ve gelenekler, kullanılan eşyalar ve kelimeler gibi birçok unsuru kullanarak eserlerine şekil vermişlerdir. Divan şairlerimiz de diğer sanatkârlar gibi eserlerini kaleme alırken, içinde yaşadıkları toplumun sosyal hayatından ilham almışlar, günlük hayatta kabul gören maddî ve manevî kültürel değerleri şiirlerde bolca kullanmışlardır. 17. yüzyılın ikinci yarısında yetişen Sâbit de yaşadığı döneme dair, iyi bir gözlem ve tahlil yaparak günlük hayata kayıtsız kalmamış, bu gözlem ve tahlillerini değişik hayallerle süsleyerek şiirlerine ustaca yansıtmasını başarmıştır. Bu çalışmada, Sâbit’in şiirlerinde 17. yüzyıldaki sosyal hayatı yansıtan unsurlar, çeşitli başlıklar altında sınıflandırılarak bunlara Divan’ından örnekler verilecektir.

    16. Historia del Laboratorio Clínico en Bogotá

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      Alberto Gómez Gutiérrez

      2008-12-01

      Full Text Available

      Pioneros del Laboratorio Clínico Bogotano en el Siglo XX.

      Federico Lleras Acosta
      César Uribe Piedrahita
      Pedro J. Almánzar
      Roberto Franco Franco
      Andrés Soriano Lleras
      Hernando Forero Rubio
      Luis Patiño Camargo
      Alfonso Rueda Herrera
      Venancio Rueda Angarita
      Guillermo Aparicio Jaramillo
      Hernando Groot Liévano
      Eduardo Caballero Ferreira
      Daniel Gamboa Galvis
      César Mendoza Posada
      Luis Callejas Arboleda
      César Gómez Vil legas
      Hernando Gómez Vesga
      Carlos Gómez Vesga
      Francisco de Castro
      Alfredo Escallón Anjel
      Irenarco Venegas
      Jaime Saravia
      Fernando Cortés Boshell
      Victor Ortiz Manrique
      Miguel Guzmán Urrego
      Carlos García Cortés
      Beatriz Cavelier Gaviria
      Blanca Osario de Patiño
      Pala Grutzlender
      r\\lelly de Cediel
      Hermana Rosa
      Cecilia de Caro
      Inés Gómez Delgado

      El primer Laboratorio Clinico de la historia fue un espacio reducido con una mesa y un asiento, y

      contaba con un único instrumento que era el propio médico que observaba, probaba e interpretaba un
      fluido obtenido involuntariamente por su paciente: su orina. Un pequeño frasco de vidrio bastaba
      para preparar la prueba. El valor diagnóstico de la orina fue sustentándose con la experiencia médica
      esencialmente árabe y judía, y ya en el siglo IX de nuestra era el médico Jacob Isaac Ben Salomón Al
      Israelí (c860-953 había escrito el libro que sería traducido en la Escuela Salernitana del siglo XI por
      Constantino el Africano (c1 01 0-1 087 bajo el título de Liber de urinis.

    17. LA DENSIDAD Y TAMAÑO DE PLÁNTULAS CON CEPELLÓN EN LA PRODUCCIÓN DE ESPÁRRAGO VERDE

      Directory of Open Access Journals (Sweden)

      Ana Mar\\u00EDa Castagnino

      2011-01-01

      Full Text Available Con el objetivo de determinar la influencia del tamaño de la celda utilizada para la obtención de plántulas de espárrago y la densidad o marco de plantación empleado, sobre la producción de turiones, se evaluó en invernadero tres tamaños de celda: 1 PG: grande (70 cm3, 2 PM: mediana (30 cm3 y 3 PCh: pequeña (20 cm3 y tres densidades (35 714 (D1; 23 810 (D2 y 17 857 (D3 plantas/ha. Se efectuó un trabajo en la Chacra Experimental de la Facultad de Agronomía, en Azul, provincia de Buenos Aires. La plantación en el campo se efectuó en noviembre 2002, setenta días después de la siembra del almácigo con plántulas con cepellón. La cosecha se realizó del 25/09 al 18/10 del año 2006, en el cuarto año desde la plantación, con una frecuencia de cosecha de día por medio. Se realizó un análisis de la varianza, con un diseño completamente al azar y considerando como factor: el tamaño de las plántulas que provenían de cada contenedor y tres densidades. En el segundo año evaluado, la densidad D1 fue la de mayor producción (4450 kg/ha netos totales y mayor cantidad de turiones (380 166. Las plantas provenientes de los dos mayores tamaños de celda produjeron 4 t/ha netas en promedio. Las bandejas de siembra de tamaño G y D1 resultaron más apropiados para la producción de espárrago ya que permitieron obtener el mayor rendimiento en peso y número, y obtener un mejor aparato radical.

    18. Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs using a selective genotyping approach.

      Science.gov (United States)

      Fontanesi, L; Galimberti, G; Calò, D G; Fronza, R; Martelli, P L; Scotti, E; Colombo, M; Schiavo, G; Casadio, R; Buttazzoni, L; Russo, V

      2012-08-01

      Combining different approaches (resequencing of portions of 54 obesity candidate genes, literature mining for pig markers associated with fat deposition or related traits in 77 genes, and in silico mining of porcine expressed sequence tags and other sequences available in databases), we identified and analyzed 736 SNP within candidate genes to identify markers associated with back fat thickness (BFT) in Italian Large White sows. Animals were chosen using a selective genotyping approach according to their EBV for BFT (276 with most negative and 279 with most positive EBV) within a population of ≈ 12,000 pigs. Association analysis between the SNP and BFT has been carried out using the MAX test proposed for case-control studies. The designed assays were successful for 656 SNP: 370 were excluded (low call rate or minor allele frequency A polymorphism (P(nominal) G polymorphism (P(nominal) = 8.0E-05). The third top SNP (P(nominal) = 6.2E-04) was the intronic TBC1D1 g.219G>A polymorphic site, in agreement with our previous results obtained in an independent study. The list of significant markers also included SNP in additional genes (ABHD16A, ABHD5, ACP2, ALMS1, APOA2, ATP1A2, CALR, COL14A1, CTSF, DARS, DECR1, ENPP1, ESR1, GH1, GHRL, GNMT, IKBKB, JAK3, MTTP, NFKBIA, NT5E, PLAT, PPARG, PPP2R5D, PRLR, RRAGD, RFC2, SDHD, SERPINF1, UBE2H, VCAM1, and WAT). Functional relationships between genes were obtained using the Ingenuity Pathway Analysis (IPA) Knowledge Base. The top scoring pathway included 19 genes with a P(nominal) < 0.1, 2 of which (IKBKB and NFKBIA) are involved in the hypothalamic IKKβ/NFκB program that could represent a key axis to affect fat deposition traits in pigs. These results represent a starting point to plan marker-assisted selection in Italian Large White nuclei for BFT. Because of similarities between humans and pigs, this study might also provide useful clues to investigate genetic factors affecting human obesity.

    19. Parámetros genéticos y heredabilidad en calidad fisiológica de semilla de jitomate (Lycopersicon esculentum Mill.

      Directory of Open Access Journals (Sweden)

      E. Rodríguez

      2000-01-01

      Full Text Available Para estimar los parámetros genéticos y heredabilidad en caracteres de calidad fisiológica de semilla de jitomate, se generó un dialélico completo con 10 líneas experimentales; con la semilla obtenida se realizaron: prueba de germinación estándar a 25 oC y 24 horas de luz en germinadora, y prueba de emergencia en almácigo bajo invernadero. Los componentes de varianza se obtuvieron considerando endogamia de 7/8 en las líneas. Los efectos genéticos fueron principalmente dominantes, excepto en germinación inicial y semillas muertas donde fueron aditivos y dominantes. Los valores de heredabilidad en sentido estrecho fueron bajos. Además se presentaron efectos maternos en germinación total y semillas muertas; y efectos recíprocos en velocidad de emergencia y en todas las variables de germinación, excepto plántulas anormales. Las mejores líneas por aptitud combinatoria general fueron CPJL-1-2-1 y CPJL-24-5-4; y por sus efectos maternos fueron CPJL-1-2-1, CPJL-3-2-1, CPJL-7-8-4 y CPJL-25-8-4. Por su aptitud combinatoria específica, en germinación los mejores híbridos fueron CPJL-7-8-4 X CPJL-22-4-4, y CPJL-1-2-1 X CPJL-2-2-1; y en emergencia CPJL-2-2-1 X CPJL-21-1-4 y CPJL-2-2-1X CPJL-22-4-4. Por los efectos recíprocos en germinación, las mejores cruzas fueron CPJL-25-8-4 X CPJL-10-1-4 y CPJL-22-4-4 X CPJL-7-8-4; y en emergencia CPJL- 24-5-4 X CPJL-10-1-4 y CPJL-10-1-4 X CPJL-2-2-1.

    20. Retinal hemodynamic influence of compound xueshuantong capsule on nonproliferative diabetic retinopathy after laser photocoagulation%复方血栓通对NPDR激光光凝术后的视网膜血流动力学影响

      Institute of Scientific and Technical Information of China (English)

      王禹燕; 刘映霞; 麦少云; 邱建文; 李岚

      2014-01-01

      AlM: To observe retinal hemodynamic influence of compound xueshuantong capsule on nonproliferative diabetic retinopathy ( NPDR) after laser photocoagulation.METHODS:A total of 41 patients (72 eyes) with NPDR after laser photocoagulation were enrolled in this study. They were all given compound xueshuantong capsule, and used color Doppler flow imaging for detection of retinal hemodynamics. RESULTS: After treatment, patients with retinal blood perfusion significantly improved; central retinal arterial peak systolic velocity ( PSV ) , end - diastolic velocity (EDV) and medial velocity (Vm) were increased, while the resistance index ( Rl) decreased. The difference have statistical significance (P CONCLUSlON: Compound xueshuantong capsule can improve retinal blood perfusion for nonproliferative diabetic retinopathy after laser photocoagulation, which is related to improvement of visual prognosis.%目的:观察复方血栓通对非增生性糖尿病性视网膜病变( nonproliferative diabetic retinopathy,NPDR)激光光凝术后的视网膜血流动力学的影响。  方法:选取已行激光光凝术后的NPDR患者41例72眼,给予复方血栓通治疗,于治疗前后,采用彩色多普勒血流检测仪检测视网膜血流动力学情况。  结果:治疗后患眼视网膜血流灌注有明显改善,视网膜中央动脉的收缩期峰值血流速度( PSV)、舒张末期血流速度( EDV)和平均血流速度( Vm)均增高,而阻力指数( RI)降低,差异有统计学意义(P  结论:复方血栓通对NPDR激光光凝术后患者的视网膜血流灌注有明显改善,并且这种改善和患者视力预后的改善密切相关。