WorldWideScience

Sample records for tre erindringsbaserede rundrejser

  1. Tre ting mangler i Nykredit-debatten

    DEFF Research Database (Denmark)

    Østrup, Finn

    2016-01-01

    Det har mudret debatten om Nykredits bidragssatser, at flere synspunkter er decideret forkerte. Og samtidig mangler vi at diskutere tre vigtige pointer.......Det har mudret debatten om Nykredits bidragssatser, at flere synspunkter er decideret forkerte. Og samtidig mangler vi at diskutere tre vigtige pointer....

  2. Théâtre de Carouge

    CERN Multimedia

    Staff Association

    2014-01-01

    Venez rire et profitez c'est bientôt les fêtes ! Même Au Théâtre de Carouge-Atelier de Genève ! Profitez de votre tarif pour découvrir la pièce la plus drôle de tous les temps ! venez rire autour de : Silence en coulisses (Noises off) de Michael Frayn et mise en scène de Raoul Pastor Du vendredi 5 au mercredi 31 décembre 2014 ! Certaines dates sont déjà complète ! With English surtitles on December 16th, 17th, 18th, 19th, 20th and 21st Du théâtre dans le théâtre, un chef d'œuvre d'horlogerie dont la mécanique comique nous offre une pièce délirante, une parabole sur le théâtre où l'on tourne en dérision acteurs et metteur en scène. En trois actes, l'auteur nous dépeint l...

  3. Supervision og de tre k´er

    DEFF Research Database (Denmark)

    Schilling, Benedicte; Jacobsen, Claus Haugaard; Nielsen, Jan

    2010-01-01

    Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?......Kontrol, kontrakt og kontekst er supervisionens tre k'er. Men hvad er supervision i det hele taget for en størrelse, der spillerså central en rolle for den psykologfaglige profession?...

  4. Théâtre Carouge

    CERN Document Server

    Théâtre Carouge

    2012-01-01

    Du ve. 24 février au di. 18 mars 2012 Salle François-Simon – Création   FIGARO !   D’après BEAUMARCHAIS Mise en scène de JEAN LIERMIER   Jean Liermier dit souvent qu’il ne fait pas de différence entre le théâtre et la vie. Que sa vie est théâtre. Rien d’étonnant alors à ce qu’il remonte le cours de son propre fleuve et prenne comme point de départ de Figaro ! la dernière scène de son Jeu de l’amour et du hasard. Un processus rappelant que pour lui, « la représentation n’est jamais une conclusion ». Les membres de l’AP et un accompagnant de leur choix peuvent bénéficier du tarif spécial de CHF 35.– (par personne) au lieu de CHF 40.–.

  5. Tre strejker i det offentlige

    DEFF Research Database (Denmark)

    Stamhus, Jørgen; Scheuer, Steen; Chrstensen, Ellen Susanne

    2010-01-01

    Fra april til juni 2008 gik tre grupper af offentligt ansatte (sosu-assistenter, sygeplejersker m.fl. og børnehavepædagoger) i strejke for at opnå forbedrede relative løngevinster. Kunne dette betale sig? På grundlag af en investeringskalkule påvises det, at kun en velforberedt og relativt kort s...

  6. Lemaître, the Big Bang and the Quantum Universe

    Science.gov (United States)

    Heller, Michael

    Lemaître's work on the geometric nature of singularities and his speculations concerning the applications of quantum physics to cosmology are confronted with later achievements in these fields. His works on the global structure of the de Sitter solution and the appearance of "non-regular" points in the Schwarzschild solution led to the conclusion that the "vanishing of the radius of the universe" is a generic property of cosmological models. This conclusion was strengthened when Lemaître proved that, against Einstein's intuition, space anisotropy (in Bianchi I models) does not remove the singularity. This is why Lemaître regarded the initial singularity as a "geometric support" of his Primeval Atom hypothesis. This hypothesis was not yet a quantum gravity idea (in the present sense of this expression), but it was certainly an application of quantum physics to the early stages of cosmic evolution. The beginning itself is aspatial and atemporal, and both space and time emerge only when the simplicity of the Primeval Atom gives place to physical multiplicity. How do the problems with which Lemaître struggled appear in the light of the present state of cosmological research?

  7. Aa. Vv., Alain Resnais et le théâtre

    OpenAIRE

    Brangé, Mireille

    2016-01-01

    Le présent numéro propose onze études sur les rapports du cinéaste Alain Resnais (né en 1922) avec le théâtre, sa passion première, dont la présence, loin d’être l’objet d’un glissement de plus en plus visible dans son œuvre depuis Mélo en 1985, y a toujours été présent, comme le signale Jean-Louis Libois dans Théâtre, cinéma, l’autre scène (pp. 17-23). Le réalisateur préfère le terme de «spectacle» pour parler de leur coprésence dans ses films et Vincent Amiel permet dans Comme au théâtre! N...

  8. Théâtre de Carouge

    CERN Document Server

    Théâtre de Carouge

    2012-01-01

     Du venderdi 24 février au dimanche 18 mars Salle François-Simon – Création FIGARO !  D’après Beaumarchais Mise en scène de Jean Liermier Jean Liermier dit souvent qu’il ne fait pas de différence entre le théâtre et la vie. Que sa vie est théâtre. Rien d’étonnant alors à ce qu’il remonte le cours de son propre fleuve et prenne comme point de départ de Figaro ! la dernière scène de son Jeu de l’amour et du hasard. Un processus rappelant que pour lui, « la représentation n’est jamais une conclusion ». Nous avons le plaisir de vous faire profiter d’un tarif spécial, pour les membres de l’Association du personnel du CERN + 1 accompagnant, de CHF 35.- (par personne) au lieu de CHF 40.-. Plus d&...

  9. Théâtre Les 50

    CERN Multimedia

    Théâtre Les 50

    2010-01-01

    Vendredi 1 et samedi 2 octobre 2010 à 20h00 Théâtre en langue anglaise.   WAITING FOR GODOT From Samuel Beckett A Theatre Someone production    Cast Estragon Gary Bird, Vladimir Alan Leather, Lucky Andrew Brookes, Pozzo Joe Pirri, A boy Gabriel Bird Crew Director Sue Humphreys, Producer Dave Humphreys, Technical Steve Pavis   Waiting for Godot is an absurdist play by Samuel Beckett, in which two characters, Vladimir and Estragon, wait for someone named Godot. Godot's absence, as well as numerous other aspects of the play, have led to many different interpretations since the play's premiere. The play is considered by some critics to be one of the most prominent works of the "Theatre of the Absurd".   Théâtre Les 50 à Saint Jean de Gonville Vendredi 1 octobre 2010 à 20h Samedi 2 octobre 2010 à 20h Tarif plein : 18 € Tarif abonné, ense...

  10. Théâtre les 50

    CERN Document Server

    Théâtre les 50

    2011-01-01

    Le Théâtre Les 50 de Saint Jean de Gonville propose : ARAGON CHANTÉ ET PARLÉ : Ferré, Ferrat, Brassens LOUIS ARAGON, écrivain et poète français ... Cofondateur de la revue Libération en 1919, avec André Breton et Philippe Soupault, Aragon publia l'un des meilleurs romans surréalistes, Le Paysan de Paris (1926). Lié à la Résistance durant toute l'occupation, Aragon participa après la guerre aux activités du Parti communiste français. Son œuvre poétique fut marquée par son amour pour sa compagne, Elsa Triolet. À partir de la fin des années 1950, nombre de ses poèmes ont été mis en musique et chantés notamment par Jean Ferrat et Léo Ferré, contribuant à faire connaître son œ...

  11. Georges Lemaître: The Priest Who Invented the Big Bang

    Science.gov (United States)

    Lambert, Dominique

    This contribution gives a concise survey of Georges Lemaître works and life, shedding some light on less-known aspects. Lemaître is a Belgian catholic priest who gave for the first time in 1927 the explanation of the Hubble law and who proposed in 1931 the "Primeval Atom Hypothesis", considered as the first step towards the Big Bang cosmology. But the scientific work of Lemaître goes far beyond Physical Cosmology. Indeed, he contributed also to the theory of Cosmis Rays, to the Spinor theory, to Analytical mechanics (regularization of 3- Bodies problem), to Numerical Analysis (Fast Fourier Transform), to Computer Science (he introduced and programmed the first computer of Louvain),… Lemaître took part to the "Science and Faith" debate. He defended a position that has some analogy with the NOMA principle, making a sharp distinction between what he called the "two paths to Truth" (a scientific one and a theological one). In particular, he never made a confusion between the theological concept of "creation" and the scientific notion of "natural beginning" (initial singularity). Lemaître was deeply rooted in his faith and sacerdotal vocation. Remaining a secular priest, he belonged to a community of priests called "The Friends of Jesus", characterized by a deep spirituality and special vows (for example the vow of poverty). He had also an apostolic activity amongst Chinese students.

  12. Tre teorier om den moralske udvikling

    DEFF Research Database (Denmark)

    Bo, Inger Glavind; Andreasen, Brian Kjær

    I artiklen gennemgås tre forskellige men teorihistorisk relaterede perspektiver på forståelsen af moralsk udvikling: Piaget, Kohlberg og Gilligan. I den efterfølgende diskussion af disse teoretikeres respektive positioner påpeges såvel forskelle som ligheder i deres betoning af moralens karakter...

  13. Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells.

    Directory of Open Access Journals (Sweden)

    Prabhat S Kunwar

    2003-12-01

    Full Text Available In most organisms, germ cells are formed distant from the somatic part of the gonad and thus have to migrate along and through a variety of tissues to reach the gonad. Transepithelial migration through the posterior midgut (PMG is the first active step during Drosophila germ cell migration. Here we report the identification of a novel G protein-coupled receptor (GPCR, Tre1, that is essential for this migration step. Maternal tre1 RNA is localized to germ cells, and tre1 is required cell autonomously in germ cells. In tre1 mutant embryos, most germ cells do not exit the PMG. The few germ cells that do leave the midgut early migrate normally to the gonad, suggesting that this gene is specifically required for transepithelial migration and that mutant germ cells are still able to recognize other guidance cues. Additionally, inhibiting small Rho GTPases in germ cells affects transepithelial migration, suggesting that Tre1 signals through Rho1. We propose that Tre1 acts in a manner similar to chemokine receptors required during transepithelial migration of leukocytes, implying an evolutionarily conserved mechanism of transepithelial migration. Recently, the chemokine receptor CXCR4 was shown to direct migration in vertebrate germ cells. Thus, germ cells may more generally use GPCR signaling to navigate the embryo toward their target.

  14. 40 CFR Table 2 to Subpart D of... - TRE Parameters for NSPS Referencing Subpartsa

    Science.gov (United States)

    2010-07-01

    ...? Net heating value(MJ/scm)b Vent stream flow rate (scm/min)c Values of terms for TRE equation: TRE=A... § 65.64(h). b MJ/scm = mega Joules per standard cubic meter. c scm/min = standard cubic meters per...

  15. Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.

    Directory of Open Access Journals (Sweden)

    Lakshmikanth Mariyanna

    Full Text Available Over the previous years, comprehensive studies on antiretroviral drugs resulted in the successful introduction of highly active antiretroviral therapy (HAART into clinical practice for treatment of HIV/AIDS. However, there is still need for new therapeutic approaches, since HAART cannot eradicate HIV-1 from the infected organism and, unfortunately, can be associated with long-term toxicity and the development of drug resistance. In contrast, novel gene therapy strategies may have the potential to reverse the infection by eradicating HIV-1. For example, expression of long terminal repeat (LTR-specific recombinase (Tre-recombinase has been shown to result in chromosomal excision of proviral DNA and, in consequence, in the eradication of HIV-1 from infected cell cultures. However, the delivery of Tre-recombinase currently depends on the genetic manipulation of target cells, a process that is complicating such therapeutic approaches and, thus, might be undesirable in a clinical setting. In this report we demonstrate that E.coli expressed Tre-recombinases, tagged either with the protein transduction domain (PTD from the HIV-1 Tat trans-activator or the translocation motif (TLM of the Hepatitis B virus PreS2 protein, were able to translocate efficiently into cells and showed significant recombination activity on HIV-1 LTR sequences. Tre activity was observed using episomal and stable integrated reporter constructs in transfected HeLa cells. Furthermore, the TLM-tagged enzyme was able to excise the full-length proviral DNA from chromosomal integration sites of HIV-1-infected HeLa and CEM-SS cells. The presented data confirm Tre-recombinase activity on integrated HIV-1 and provide the basis for the non-genetic transient application of engineered recombinases, which may be a valuable component of future HIV eradication strategies.

  16. SoTRE's Speak Up: Students Share the Benefits of Teacher Researcher Experiences

    Science.gov (United States)

    Eubanks, E.; Allen, S.; Farmer, S.; Jones, K.

    2016-12-01

    Being Students of Teacher Researcher Experiences (SoTRE) gives students special advantages that most students do not get. Teachers Elizabeth Eubanks and Steve Allen share their knowledge gained via partnerships with Teacher Researcher Experiences (TRE's) such as the National Oceanographic and Atmospheric Administration Teacher at Sea program (NOAA- TAS), Polar TREC (Teachers and Researchers & Exploring & Collaboration), National Science Foundation (NSF) funded researchers, (EARTH) Education and Research: Testing Hypothesis, the RJ Dunlap Marine Conservation Program, C-DEBI (Center for Dark Energy Biosphere Investigations and (STARS) Sending Teachers Aboard Research Ships, The Maury Project and Mate. Students gain special privileges such as understanding unique research ideas, tracking tagged sharks, following daily journals written on location, taking part in cross-continental experiments, tracking real time data, exploring current research via posters or visiting universities. Furthermore, contacts made by a TRE give students an added set of resources. When doing experiments for class or advancing their education or career goals Eubanks and Allen help students connect with scientists. Many students have felt so strongly about the TRE relationship that they have presented at several local and international science conferences. Their message is to encourage scientists to partner with teachers. The benefits of participation in such conferences have included abstract writing and submission, travel, poster creation, oral presentation, networking and personal research presentation, all tools that they will carry with them for a lifetime.

  17. Confessions of a TRE Junkie: What's Next? Who Cares?

    Science.gov (United States)

    Hjelm, E. J.

    2011-12-01

    Whether self-selected or chosen through a competitive process, teachers who seek out research experiences are at or near the top of their profession and often well trained in science. We incorporate our research experiences into our classrooms. We tinker and refine. We become TRE experts in our own right. How do we continue to grow and share this expertise? TRE veterans are an untapped resource. I provide a first hand, teacher account of the years after the TRE. My first was the 2005 ERESE Teacher Research Experience in Plate Tectonics at SIO. I brought an M.S. in Geology, field and middle school teaching experience, a passion for teaching geoscience, and a desire to inspire the next generation of geoscientists. I left committed to finding authentic ways for my students to conduct inquiry-based geoscience. Geoscience is taught in middle school. That's where the pipeline begins. One "real" geoscience experience in those middle years can inspire the best and the brightest to pursue geoscience careers. At SIO I embraced the idea that meaningful science involves asking and answering your own questions. My sixth grade students use NOAA OceanExplorer websites to explore subduction zones and seafloor vents. They ask and then answer their own questions. Each student communicates her results in a classroom scientific meeting. In 2006, I presented my students' work at AGU Fall Meeting. Next, I believed my students would benefit from contact with a scientist at their scientific meeting, so in 2007 we co-hosted, with Dartmouth College, a MARGINS Distinguished Lecturer. I was using NOAA websites, so in 2008 I was a NOAA Teacher at Sea in AK. My TAS experience resulted in a MARGINS minilesson that enables students to use GeoMapApp to explore and compare volcanic and glacial features on Aleutian islands and surrounding seafloor http://serc.carleton.edu/margins/minilessons/32005.html. In 2009, with an interest in visualizations and volcanoes, and a letter of support from a PI, I

  18. TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element.

    Directory of Open Access Journals (Sweden)

    Thomas Spaller

    Full Text Available The amoeba Dictyostelium discoideum has a haploid genome in which two thirds of the DNA encodes proteins. Consequently, the space available for selfish mobile elements to expand without excess damage to the host genome is limited. The non-long terminal repeat retrotransposon TRE5-A maintains an active population in the D. discoideum genome and apparently adapted to this gene-dense environment by targeting positions ~47 bp upstream of tRNA genes that are devoid of protein-coding regions. Because only ~24% of tRNA genes are associated with a TRE5-A element in the reference genome, we evaluated whether TRE5-A retrotransposition is limited to this subset of tRNA genes. We determined that a tagged TRE5-A element (TRE5-Absr integrated at 384 of 405 tRNA genes, suggesting that expansion of the current natural TRE5-A population is not limited by the availability of targets. We further observed that TRE5-Absr targets the ribosomal 5S gene on the multicopy extrachromosomal DNA element that carries the ribosomal RNA genes, indicating that TRE5-A integration may extend to the entire RNA polymerase III (Pol III transcriptome. We determined that both natural TRE5-A and cloned TRE5-Absr retrotranspose to locations on the extrachromosomal rDNA element that contain tRNA gene-typical A/B box promoter motifs without displaying any other tRNA gene context. Based on previous data suggesting that TRE5-A targets tRNA genes by locating Pol III transcription complexes, we propose that A/B box loci reflect Pol III transcription complex assembly sites that possess a function in the biology of the extrachromosomal rDNA element.

  19. Fromleik i Black Supper, Piss Christ og Crucifixion, tre fotografi av Andres Serrano

    OpenAIRE

    Vinje, Lilly

    2006-01-01

    Oppgåva skal omhandla tre utvalgte foto av fotografen Andres Serrano, ein amerikanar født i 1950. Enkeltbileta det er snakk om er Black Supper (1990), Piss Christ og Crucifixion (begge 1987). Dei er laga ved at kitschfigurar er nedsenka i gjennomsiktige behaldarar fyllte av kroppsvæsker og vatn; vatn i Black Supper, urin i Piss Christ og blod i Crucifixion. Henholdsvis framstiller dei Nattverden, Jesus på krossen og Krossfestinga (tre figurar). Serrano befinn seg med desse innanfor religiøs k...

  20. Accroître l'inclusion financière pour les femmes et les jeunes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Accroître l'inclusion financière pour les femmes et les jeunes vulnérables : Proyecto Capital. L'accès à des services financiers officiels peut aider les personnes les plus pauvres du monde à échapper à la pauvreté et à réduire leur vulnérabilité. Ce projet aidera à accroître la sécurité économique de femmes et de jeunes ...

  1. Polska prasa tabletowa – modele biznesowe dystrybucji treści

    Directory of Open Access Journals (Sweden)

    Krzysztof Flasiński

    2012-02-01

    Full Text Available Autor przeanalizował aplikacje spełniające trzy warunki: przeznaczone na tablety marki iPad, dostępne w sklepie App Store oraz powiązane z polskojęzycznymi tytułami prasowymi. Artykuł przedstawia kompletną panoramę polskiej prasy tabletowej. Ujętych zostało 38 aplikacji dostępnych 30 września 2011 r. Po zbadaniu wszystkich programów utworzono „mapę modeli biznesowych dystrybucji treści”. Czynnikiem decydującym o umieszczeniu na niej aplikacji prasowych była forma dystrybucji treści (płatna/bezpłatna oraz  rodzaj udostępnianej treści (powiązana z wydaniem drukowanym/powiązana z wydaniem online. Z analizy wynika, że 11 redakcji udostępnia płatne wydanie print, 10 – bezpłatne wydanie online, 7 – bezpłatne wydanie print, 3 – bezpłatne wydanie online oraz płatne wydanie print, jedna – oba wydania bezpłatnie, i jedna – oba wydania płatnie. Wywód uzupełniają dodatkowe dane: chronologiczna lista aplikacji prasowych według daty ukazania, wykaz kosztów korzystania z poszczególnych aplikacji, aktywność wydawców prasowych w App Store w rozbiciu na miesiące oraz kwartały.

  2. QUANTUM @ Théâtre Forum Meyrin | 30-31 October

    CERN Multimedia

    2015-01-01

    The Gilles Jobin Company has the pleasure of welcoming you to QUANTUM @ Théâtre Forum Meyrin.   QUANTUM @ Théâtre Forum Meyrin Friday, 30 October - 8.30 p.m.  Saturday, 31 October - 7.00 p.m. SPECIAL PRICE FOR CERN PERSONNEL: 15 CHF upon presentation of your CERN card (regular price: 25 CHF/20 CHF). QUANTUM is a "creative collision" between 2012 Arts@CERN resident artists Gilles Jobin, choreographer, and Julius Von Bismarck, visual artist. Von Bismarck's lumino-kinetic installation lights up the stage while Carla Scaletti's music score uses real LHC "sonified" data! Physicists Michael Doser and Nicholas Chanon participated in the creation as scientific advisors to the choreographer. Created at the CMS ex...

  3. Georges Lemaître and Fred Hoyle: Contrasting Characters in Science and Religion

    Science.gov (United States)

    Holder, Rodney D.

    Georges Lemaître was a jocular Roman Catholic priest and Fred Hoyle a bluff Yorkshireman who despised organized religion. Both were giants of twentieth century cosmology but espoused diametrically opposed cosmological models. This paper explores the extent to which ideology, and particularly religion, played a part in the controversies over the big bang and steady-state theories. A particular problem for many cosmologists, including Hoyle, was posed by the idea that the universe had a temporal beginning: an eternal, unchanging universe seemed metaphysically preferable. And Hoyle was highly polemical about religion in his popular writings. In contrast, Lemaître saw no theological import from the big bang, and never entered a debate about its theological implications until, perhaps unexpectedly, he took issue with an address given by the Pope. Hoyle's seminal work on stellar nucleosynthesis led him to speak of a `superintellect monkeying with physics' though this was never identified with the God of classical theism. The work of both Lemaître and Hoyle resonates with more recent debates concerning cosmology.

  4. 40 CFR 63.117 - Process vent provisions-reporting and recordkeeping requirements for group and TRE determinations...

    Science.gov (United States)

    2010-07-01

    ... provisions for Group 2 process vents with a TRE index value greater than 1.0 but less than or equal to 4.0 in... report the following when achieving and maintaining a TRE index value greater than 1.0 but less than 4.0... than 4.0 as specified in § 63.113(e) of this subpart, shall maintain records and submit as part of the...

  5. Fra Bach til Beatles på tre måneder!

    DEFF Research Database (Denmark)

    Bonde, Anders

    2006-01-01

    Fra Bach til Beatles på tre måneder! Didaktiske overvejelser og erfaringer på baggrund af nyt et-semesters oversigtskursus Anders Bonde Fra og med september 2005 har man på musikuddannelsen ved Aalborg Universitet, som led i implementeringen af en ny tofaglig bachelorstruktur, udviklet et nyt...

  6. Tre gordiske knuder eller bare bump på vejen

    DEFF Research Database (Denmark)

    Hansen, Nana Wesley; Mailand, Mikkel

    I notatet analyseres forventningerne til OK2018, der særligt byder på tre udfordringer. Det gælder uenighed om privatlønsværn og løngab, samarbejdsproblemer på statens område (herunder spørgsmålet om den betalte frokostpause) og spørgsmålet om lærernes arbejdstid. Notatet understreger den særlige...

  7. Study on the Effect of Wing Bud Chitin Metabolism and Its Developmental Network Genes in the Brown Planthopper, Nilaparvata lugens, by Knockdown of TRE Gene

    Directory of Open Access Journals (Sweden)

    Lu Zhang

    2017-09-01

    Full Text Available The brown planthopper, Nilaparvata lugens is one of the most serious pests of rice, and there is so far no effective way to manage this pest. However, RNA interference not only can be used to study gene function, but also provide potential opportunities for novel pest management. The development of wing plays a key role in insect physiological activities and mainly involves chitin. Hence, the regulating role of trehalase (TRE genes on wing bud formation has been studied by RNAi. In this paper, the activity levels of TRE and the contents of the two sugars trehalose and glucose were negatively correlated indicating the potential role of TRE in the molting process. In addition, NlTRE1-1 and NlTRE2 were expressed at higher levels in wing bud tissue than in other tissues, and abnormal molting and wing deformity or curling were noted 48 h after the insect was injected with any double-stranded TRE (dsTRE, even though different TREs have compensatory functions. The expression levels of NlCHS1b, NlCht1, NlCht2, NlCht6, NlCht7, NlCht8, NlCht10, NlIDGF, and NlENGase decreased significantly 48 h after the insect was injected with a mixture of three kinds of dsTREs. Similarly, the TRE inhibitor validamycin can inhibit NlCHS1 and NlCht gene expression. However, the wing deformity was the result of the NlIDGF, NlENGase, NlAP, and NlTSH genes being inhibited when a single dsTRE was injected. These results demonstrate that silencing of TRE gene expression can lead to wing deformities due to the down-regulation of the AP and TSH genes involved in wing development and that the TRE inhibitor validamycin can co-regulate chitin metabolism and the expression of wing development-related genes in wing bud tissue. The results provide a new approach for the prevention and management of N. lugens.

  8. Study on the Effect of Wing Bud Chitin Metabolism and Its Developmental Network Genes in the Brown Planthopper, Nilaparvata lugens, by Knockdown of TRE Gene.

    Science.gov (United States)

    Zhang, Lu; Qiu, Ling-Yu; Yang, Hui-Li; Wang, Hui-Juan; Zhou, Min; Wang, Shi-Gui; Tang, Bin

    2017-01-01

    The brown planthopper, Nilaparvata lugens is one of the most serious pests of rice, and there is so far no effective way to manage this pest. However, RNA interference not only can be used to study gene function, but also provide potential opportunities for novel pest management. The development of wing plays a key role in insect physiological activities and mainly involves chitin. Hence, the regulating role of trehalase (TRE) genes on wing bud formation has been studied by RNAi. In this paper, the activity levels of TRE and the contents of the two sugars trehalose and glucose were negatively correlated indicating the potential role of TRE in the molting process. In addition, NlTRE1-1 and NlTRE2 were expressed at higher levels in wing bud tissue than in other tissues, and abnormal molting and wing deformity or curling were noted 48 h after the insect was injected with any double-stranded TRE ( dsTRE ), even though different TREs have compensatory functions. The expression levels of NlCHS1b, NlCht1, NlCht2, NlCht6, NlCht7, NlCht8, NlCht10, NlIDGF , and NlENGase decreased significantly 48 h after the insect was injected with a mixture of three kinds of dsTREs . Similarly, the TRE inhibitor validamycin can inhibit NlCHS1 and NlCht gene expression. However, the wing deformity was the result of the NlIDGF, NlENGase, NlAP , and NlTSH genes being inhibited when a single dsTRE was injected. These results demonstrate that silencing of TRE gene expression can lead to wing deformities due to the down-regulation of the AP and TSH genes involved in wing development and that the TRE inhibitor validamycin can co-regulate chitin metabolism and the expression of wing development-related genes in wing bud tissue. The results provide a new approach for the prevention and management of N. lugens .

  9. Evaluering af Københavns kommunes tre Agenda 21 centre og sattellitter

    DEFF Research Database (Denmark)

    Agger, Annika; Hoffmann, Birgitte; Jensen, Jesper Ole

    Evaluering af Københavns kommunes tre første Agenda 21 centre på Indre Nørrebro, Bispebjerg, Sundbyøster samt sattellitterne på Østerbro og Ydre Nørrebro. Evalueringen fokuserer på centrenes forankring i lokale organisationer og netværk, samt forventningsafklaring mellem de mange involverede...

  10. Implementering af tre misbrugsbehandlinger for udsatte unge

    DEFF Research Database (Denmark)

    Weatherall, Cecilie Dohlmann; Termansen, Tina

    2015-01-01

    SFI- Det Nationale Forskningscenter for Velfærd skal evaluere ”Projekt misbrugsbehandling for udsatte unge”, som løber fra 2011 til 2014. De tre behandlingsmodeller, som indgår i Socialstyrelsens (SOS) ”Projekt misbrugsbehandling for udsatte unge”, er MST-SA (Multi Systemic Therapy Substance Abuse...... både i Danmark og internationalt. Dog er der et stigende fokus på, at det er et centralt element for at opnå gode evalueringer (Fixen m.fl., 2005; Fixen m.fl., 2009; Durlak & DuPre, 2008), idet implementeringen af en indsats kan have stor betydning for den effekt, der observeres. Ifølge Durlak og Du...

  11. 40 CFR Table 4 to Subpart G of... - Process Vents-Monitoring, Recordkeeping, and Reporting Requirements For Maintaining a TRE Index...

    Science.gov (United States)

    2010-07-01

    ..., and Reporting Requirements For Maintaining a TRE Index Value >1.0 and. â¤4.0 4 Table 4 to Subpart G of... TRE Index Value >1.0 and. ≤4.0 Final recovery device Parameters to be monitored a Recordkeeping and... for Organic Hazardous Air Pollutants From the Synthetic Organic Chemical Manufacturing Industry for...

  12. Conditional RNA interference achieved by Oct-1 POU/rtTA fusion protein activator and a modified TRE-mouse U6 promoter

    International Nuclear Information System (INIS)

    Fei Zhaoliang; Chen Zheng; Wang Zhugang; Fei Jian

    2007-01-01

    RNA interference (RNAi) is a powerful technique and is widely used to down-regulate expression of specific genes in cultured cells and in vivo. In this paper, we report our development of a new tetracycline-inducible RNAi expression using a modified TRE-mouse U6 promoter in which the distal sequence element (DSE) was replaced by the tetracycline-responsive element (TRE). The modified TRE-mouse U6 promoter can be activated by a Tet-on version tetracycline-regulated artificial activator rTetOct which was constructed by fusing the rtTA DNA binding domain with the Oct-1 POU activation domain. This rTetOct/TRE-U6 system was successfully applied to conditionally and reversibly down-regulate the expression of endogenous p53 gene in MCF7 cells, and the expression of β-defensin gene (mBin1b) either transiently expressed in COS7 cells or stably expressed in CHO cells

  13. Densità informativa. Tre parametri linguistico-testuali

    DEFF Research Database (Denmark)

    Jansen, Hanne

    ) il rapporto fra informazione "vera e propria" e materiale linguistico adempiente invece a funzioni testuali ed interpersonali. Dopo una discussione dei presupposti teorici e metodologici (in particolare della stessa nozione di "informazione" e di quella altrettanto importante, di "unità di......In una prospettiva contrastiva e su una base eclettica, funzionale/cognititiva/testuale, lo studio si propone di definire la densità informativa di un testo in base a tre parametri: 1) il rapporto fra informazione esplicita e implicita; 2) la strutturazione concreta dell'unità di informazione; 3...... informazione"), è messo a prova il modello d'analisi proposto, confrontando i testi del corpus di Mr. Bean (testi paralleli italiani e danesi, scritti e parlati)...

  14. The role of Tre6P and SnRK1 in maize early kernel development and events leading to stress-induced kernel abortion.

    Science.gov (United States)

    Bledsoe, Samuel W; Henry, Clémence; Griffiths, Cara A; Paul, Matthew J; Feil, Regina; Lunn, John E; Stitt, Mark; Lagrimini, L Mark

    2017-04-12

    Drought stress during flowering is a major contributor to yield loss in maize. Genetic and biotechnological improvement in yield sustainability requires an understanding of the mechanisms underpinning yield loss. Sucrose starvation has been proposed as the cause for kernel abortion; however, potential targets for genetic improvement have not been identified. Field and greenhouse drought studies with maize are expensive and it can be difficult to reproduce results; therefore, an in vitro kernel culture method is presented as a proxy for drought stress occurring at the time of flowering in maize (3 days after pollination). This method is used to focus on the effects of drought on kernel metabolism, and the role of trehalose 6-phosphate (Tre6P) and the sucrose non-fermenting-1-related kinase (SnRK1) as potential regulators of this response. A precipitous drop in Tre6P is observed during the first two hours after removing the kernels from the plant, and the resulting changes in transcript abundance are indicative of an activation of SnRK1, and an immediate shift from anabolism to catabolism. Once Tre6P levels are depleted to below 1 nmol∙g -1 FW in the kernel, SnRK1 remained active throughout the 96 h experiment, regardless of the presence or absence of sucrose in the medium. Recovery on sucrose enriched medium results in the restoration of sucrose synthesis and glycolysis. Biosynthetic processes including the citric acid cycle and protein and starch synthesis are inhibited by excision, and do not recover even after the re-addition of sucrose. It is also observed that excision induces the transcription of the sugar transporters SUT1 and SWEET1, the sucrose hydrolyzing enzymes CELL WALL INVERTASE 2 (INCW2) and SUCROSE SYNTHASE 1 (SUSY1), the class II TREHALOSE PHOSPHATE SYNTHASES (TPS), TREHALASE (TRE), and TREHALOSE PHOSPHATE PHOSPHATASE (ZmTPPA.3), previously shown to enhance drought tolerance (Nuccio et al., Nat Biotechnol (October 2014):1-13, 2015). The impact

  15. En, to, tre - tjek på branding

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2010-01-01

    Da brandet i såvel juridisk som marketingmæssig forstand er et tegn, er det oplagt at vende sig mod semiotikken i forsøget på at udvikle en model, der kan integrere de forskellige komponenter, som brand-tegnet består af. Forfatterne undersøger dimensionerne ’identitet’, ’marketing’ og ’respons’ ved...... hjælp af Peirce's tredelte tegnbegreb og udvikler en model, der illustrerer brandets anatomi i form af tre ”søjler”: 1) Identitetssøjlen, som er et mix af tegn og brands, 2) Marketingsøjlen, som er et mix af produkter og marketing aktiviteter og 3) Responssøjlen, som er et mix af forskellige markeder og...

  16. Alexandre Hardy, Théâtre complet, Tome I

    OpenAIRE

    Pavesio, Monica

    2016-01-01

    Il primo volume del teatro completo di Alexandre Hardy, pubblicato nella collezione della Bibliothèque du théâtre français diretta da Charles Mazouer, presenta le edizioni critiche delle pièces contenute nel primo volume del drammaturgo, stampato per la prima volta a Parigi nel 1624. Si tratta del primo risultato di un lavoro più vasto che prevede, nei prossimi anni, la pubblicazione dell’intero corpus delle opere teatrali del grande drammaturgo del primo Seicento, grazie al lavoro di un’équi...

  17. La m?taplasie osteoide de l'endom?tre apr?s une grossesse ? terme: ? propos d'un cas rare

    OpenAIRE

    Jayi, Sofia; Bouguern, Hakima; Fatemi, Hind; Chaara, Hikmat; Laamarti, Afaf; Melhouf, Aabdelilah

    2013-01-01

    La m?taplasie ost?o?de de l'endom?tre (MOE) est une entit? rare correspondant ? la pr?sence de tissu osseux dans l'endom?tre, elle est le plus souvent diagnostiqu?e dans un contexte d'infertilit? secondaire faisant suite ? une grossesse interrompue. M?me si plusieurs facteurs de risque sont r?pertori?s, sa physiopathologie reste mal connue et sa traduction clinique est tr?s variable. Nous rapportons un cas de MOE apparu suite ? un curetage pour r?tention placentaire en post-partum. Le diagnos...

  18. Kategoriseringsmodeller, typer af kriterier og gyldighedsområder - de tre niveauer i tekstgenrerforskningen

    DEFF Research Database (Denmark)

    Frandsen, Finn

    1995-01-01

    Artiklen forsøger at vise, hvordan de metodologiske problemstillinger i studiet af tekstgenrer kan fordeles på tre forskellige forskningsniveauer, som bør holdes ude fra hinanden, uanset hvilke tekstgenrer man studerer: a) valg af kategoriseringsmodel, b) valg af typer af kriterier og c) kriterie...

  19. Georges Lemaître: Science and Religion

    Science.gov (United States)

    Coyne, George V.

    In order to appreciate the contribution which Georges Lemaître made to the relationship between religion and science it is necessary to understand how the Catholic Church, of which he was a priest, passed in the course of three centuries, from a position of conflict with the sciences to one of compatible openness and dialogue. In doing this I hope to show that the natural sciences have played a significant role in helping to establish the kind of dialogue that is absolutely necessary for the enrichment of the multifaceted aspects of human culture. I will speak of the following four periods of history: (l) the rise of modern atheism in the seventeenth and eighteenth centuries; (2) anticlericalism in Europe in the nineteenth century; (3) the awakening within the Catholic Church to modern science in the first six decades of the twentieth century; (4) the Church's view today.

  20. Improviser en classe de Français Langue Étrangère : spontanéité et réflexion à travers le théâtre-forum

    Directory of Open Access Journals (Sweden)

    Claire Del Olmo

    2015-02-01

    Full Text Available Depuis l’avènement des approches communicatives, les enseignants de Français Langue Étrangère (FLE mettent souvent en place des jeux de rôles. Cependant, leur pertinence a été remise en question. Aujourd’hui, les enseignants se tournent vers des formes de théâtre permettant aux apprenants une pratique improvisée de la langue cible. Dans cet article, nous nous proposons de mettre en avant dans quelle mesure l’improvisation inhérente au théâtre-forum favorise l’enseignement/apprentissage du FLE. Nous expliciterons, dans un premier temps, les caractéristiques du théâtre-forum. Puis, nous soulignerons les avantages de l’improvisation que comprend cette forme de théâtre quand il s’agit d’enseigner le FLE. Nous rapporterons une expérience menée auprès d’étudiants Erasmus. Nous proposerons une modélisation de la dynamique et des enjeux de l’improvisation liée au théâtre-forum dans le champ du FLE. Nous finirons par expliquer comment un enseignant peut mettre en place une séance de théâtre-forum. Notre but sera de fournir les outils nécessaires à sa mise en place.

  1. Georges Lemaître Life, Science and Legacy

    CERN Document Server

    Mitton, Simon

    2012-01-01

    The year 2011 marked the 80th anniversary of Georges Lemaître’s primeval atom model of the universe, forerunner of the modern day Big Bang theory. Prompted by this momentous anniversary the Royal Astronomical Society decided to publish a volume of essays on the life, work and faith of this great cosmologist, who was also a Roman Catholic priest. The papers presented in this book examine in detail the historical, cosmological, philosophical and theological issues surrounding the development of the Big Bang theory from its beginnings in the pioneering work of Lemaître through to the modern day. This book offers the best account in English of Lemaître’s life and work. It will be appreciated by professionals and graduate students interested in the history of cosmology.

  2. Manlighet i kris? Några anmärkningar om mansporträtt i tre populärlitterära romaner

    OpenAIRE

    Szymoniak, Katarzyna

    2010-01-01

    I artikeln konfronteras Susan Faludis och Thomas Johanssons teori om manlighetskris med mansporträtt i tre svenska populärlitterära romaner. Teorin om manlighetskris uppstod i samband med feminism. Enligt forskarna visar sig manlighetskrisen i mäns oförmåga att ingå nära relationer, ensamhet och rädsla att inte leva upp till mansidealet. Tre svenska populärromaner Pappadagar i Råttans år av Daniel Möllberg (2007), Vi som aldrig sa hora av Ronnie Sandahl (2007) and Vi har redan sagt hej då av ...

  3. Evaluering af tre projekter i Socialstyrelsens Forældreprogram

    DEFF Research Database (Denmark)

    Scavenius Sonne-Schmidt, Christoffer; Andersen, Luna Kragh; Frøslev-Thomsen, Kathrine

    2018-01-01

    I Danmark oplever vi i disse år en stigning i antallet af børn og unge med ADHD diagnoser og ADHD-lignende vanskeligheder, hvilket har medført øget fokus på effektive indsatser til de berør-te familier, børn og unge. Dette notat har til formål at beskrive implementering af tre sådanne indsatser......, herunder unge med ADHD (PMTO) samt Mentor- og støttekontaktpersons-ordningen (M-SKP) rettet mod unge. KiK og PMTO er begge manualbaserede og velafprøvede indsatser, mens M-SKP bygger på det eksisterende mentor- og støttekontaktpersonsarbejde, der foretages i danske kommuner, men i sig selv er en ny indsats...

  4. Des agriculteurs éthiopiens réussissent à accroître le rendement et ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 janv. 2013 ... Des chercheurs canadiens et éthiopiens testent, adaptent et font connaître des solutions pratiques pour la culture des légumineuses à graines dans des zones où sévit la pauvreté en Éthiopie. Le pois chiche, la lentille et le haricot, entre autres, peuvent combattre la malnutrition et mettre en disponibilité ...

  5. La marâtre dans les contes merveilleux du Yémen

    Directory of Open Access Journals (Sweden)

    Jean Lambert

    2010-07-01

    Full Text Available La figure de la marâtre est particulièrement répandue dans les contes merveilleux du Yémen. Comme en Europe, ce genre de la littérature orale remplit des fonctions d’éducation enfantine, mais il s’adresse aussi aux adultes. Au Yémen, la figure de la marâtre doit être remise dans son contexte socio-économique des familles recomposées dans une société encore rurale et patriarcale. Sans négliger le contexte de performance du conte au Yémen, ni l’intertextualité des différentes formes de contes (se rapprochant du mythe et de l’histoire de ruse, la présentation et l’analyse de cinq contes yéménites et de diverses variantes permettent d’explorer les thèmes fantasmatiques de la mère cruelle et de la monstruosité des autres membres de la famille nucléaire. D’un autre côté, inséparables du merveilleux, les agents magiques sont principalement des animaux qui symbolisent et idéalisent des degrés de parenté proche. Tout en déformant les enjeux de la vie réelle dans un sens moral, le conte yéménite révèle, par ses structures symboliques, l’existence de ce que l’on peut appeler le « complexe anthropologique » de la marâtre, et qui s’exprime aussi, au Yémen, sous d’autres formes littéraires orales qui restent encore à explorer.The literary figure of the stepmother is widely spread in the fairy tales in Yemen. Like in Europe, this genre fulfils educative functions for the children, but it is also addressed to adults. In Yemen, the figure of the stepmother must be put in perspective in the socio-economical context of recomposed families in a still rural and patriarchal society. Without neglecting the performance context of the narration, neither the intertextual weaving of different forms of “tales” (myths, tricksters tales, the presentation and the analysis of five Yemeni tales and their variants allows us to explore the fantasy themes of the cruel mother and other kinds of monstrous kinship

  6. 2. Le théâtre en révolution. Jeux et enjeux juridiques et politiques 1789–1799

    Directory of Open Access Journals (Sweden)

    Jahiel Ruffier-Méray

    2017-08-01

    Full Text Available Cette étude porte sur la manière dont le pouvoir politique a tenté d’instrumentaliser le théâtre et examine les différents moyens juridiques utilisés pour transformer l’art théâtral en outil de propagande durant la période révolutionnaire. Durant tout l’Ancien Régime, le système des spectacles privilégiés règne en maître. En plaçant certaines troupes en situation de monopole, l’État fait le choix d’une politique de régulation des salles. Quant à la surveillance des divertissements, elle est assurée à la fois par la police des spectacles et par la censure. En 1789, avec l’abolition des privilèges, les révolutionnaires remettent en cause tout ce système. Inévitablement, ils sont obligés de s’interroger sur les politiques à mener en matière théâtrale et de repenser les modalités de l’offre artistique. Le théâtre apparaît, dès lors, comme un enjeu majeur situé au cœur des préoccupations révolutionnaires. L’art dramatique concentre à lui seul, toutes les questions débattues avec passion à l’Assemblée.

  7. Tre voci per un Lexicon di Giuseppe Pontiggia

    Directory of Open Access Journals (Sweden)

    Daniela Marcheschi

    2014-07-01

    Full Text Available Tre parole-chiave offrono lo spunto per un’immersione nel pensiero e nell’opera di Giuseppe Pontiggia. La prima: parola, riaffermata dallo scrittore in quanto atto civile e ‘corporeo’ mediante il quale l’uomo fa esperienza di se stesso entrando in contatto con i suoi simili e con il circostante, ricongiungendosi insieme alla sua più profonda e antica natura. Viene così restituita allo scrittore/critico la responsabilità di lottare contro l’attuale minaccia dello svuotamento linguistico, nel nome di una costruttiva utopia culturale. La seconda parola, musica, serve a illuminare i romanzi di Pontiggia – in specie La grande sera e L’arte della fuga – attraverso suggestive analogie con la musica classica e il jazz, predilette dallo scrittore. Ossimoro è l’ultima voce di questo Lexicon: figura retorica, ma soprattutto figura conoscitiva che permette allo scrittore di scoprire la propria verità e il proprio linguaggio e al lettore di abbracciare una visione non lineare e problematica del mondo, capace di ampliare le prospettive e rinnovare lo sguardo.

  8. A novel device for measuring arterial stiffness using finger-toe pulse wave velocity: Validation study of the pOpmètre®.

    Science.gov (United States)

    Alivon, Maureen; Vo-Duc Phuong, Thao; Vignon, Virginie; Bozec, Erwan; Khettab, Hakim; Hanon, Olivier; Briet, Marie; Halimi, Jean-Michel; Hallab, Magid; Plichart, Matthieu; Mohammedi, Kamel; Marre, Michel; Boutouyrie, Pierre; Laurent, Stéphane

    2015-04-01

    The finger-toe pathway could be a good alternative for assessing arterial stiffness conveniently. To evaluate the accuracy of the pOpmètre®--a new device that measures finger-toe pulse wave velocity (ft-PWV). The pOpmètre has two photodiode sensors, positioned on the finger and the toe. Pulse waves are recorded continuously for 20 seconds, and the difference in pulse wave transit time between toe and finger (ft-TT) is calculated. The travelled distance is estimated using subject height. Study 1 compared ft-PWV with carotid-femoral PWV (cf-PWV) obtained by the reference method (SphygmoCor®) in 86 subjects (mean age 53±20 years), including 69 patients with various pathologies and 17 healthy normotensives. Study 2 compared changes in ft-PWV and cf-PWV during a cold pressor test in 10 healthy subjects. Study 3 assessed repeatability in 45 patients. ft-PWV correlated significantly with cf-PWV (R2=0.43; P<0.0001). A better correlation was found in terms of transit time (R2=0.61; P<0.0001). The discrepancy between transit times was related to age. The cold pressor test induced parallel changes in cf-PWV and ft-PWV, with increased aortic stiffness that was reversible during recovery. Intra-session repeatability was very good, with a coefficient of variation of 4.52%. The pOpmètre® allows measurement of arterial stiffness in routine clinical practice. The greatest advantages of ft-PWV are simplicity, rapidity, feasibility, acceptability by patients and correct agreement with the reference technique. Further studies are needed to adjust for bias and to validate the pOpmètre in larger populations. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  9. Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

    Directory of Open Access Journals (Sweden)

    Lukas E Dow

    Full Text Available Tetracycline or doxycycline (dox-regulated control of genetic elements allows inducible, reversible and tissue specific regulation of gene expression in mice. This approach provides a means to investigate protein function in specific cell lineages and at defined periods of development and disease. Efficient and stable regulation of cDNAs or non-coding elements (e.g. shRNAs downstream of the tetracycline-regulated element (TRE requires the robust expression of a tet-transactivator protein, commonly the reverse tet-transactivator, rtTA. Most rtTA strains rely on tissue specific promoters that often do not provide sufficient rtTA levels for optimal inducible expression. Here we describe the generation of two mouse strains that enable Cre-dependent, robust expression of rtTA3, providing tissue-restricted and consistent induction of TRE-controlled transgenes. We show that these transgenic strains can be effectively combined with established mouse models of disease, including both Cre/LoxP-based approaches and non Cre-dependent disease models. The integration of these new tools with established mouse models promises the development of more flexible genetic systems to uncover the mechanisms of development and disease pathogenesis.

  10. "Life of Galileo" Théâtre de Carouge

    CERN Multimedia

    2008-01-01

    Special offer for CERN personnel CERN personnel and their spouses have until Tuesday, 18 March 2008 to buy tickets for « Vie de Galilée » ("Life of Galileo") at the Théâtre de Carouge at the special discount rate of 28 CHF (instead of 35 CHF). This play, by the German dramatist Bertolt Brecht, is directed by Manfred Karge and recounts the life of the father of modern physics in fifteen tableaux. The wily, impassioned teacher Galileo is about to substantiate Copernicus’ theory that the Earth is not a static object but revolves around the sun, a discovery that revolutionised mankind’s view of itself and the world. When hauled before the Inquisition, he recants. "Life of Galileo" is the first major dramatic work after the invention of the atom bomb to address the issues of freedom of thought and ethics in the context of scientific discoveries. Special performances on 3, 10, 15 and 22 April will be followed by organised debat...

  11. Georges Lemaître et la théorie du big bang qu'y avait-t-il au commencement de l'univers ?

    CERN Document Server

    Landa, Pauline

    2015-01-01

    Découvrez enfin tout ce qu'il faut savoir sur Georges Lemaître et ses inventions en moins d'une heure !L'origine de l'univers, voilà une problématique qui a tenu en haleine de très nombreux scientifiques. Alors que l'on pourrait croire que l'homme s'est posé cette question depuis la nuit des temps, il n'en est rien. C'est Georges Lemaître, un prêtre belge et grand astrophysicien, qui le premier cherche à dater l'univers et à tenter de découvrir ce qu'il y avait au commencement, alors même que l'ensemble de la communauté scientifique était persuadé qu'il avait toujours exis

  12. Underviseres og studerendes erfaringer med undervisning og læring i tre formater: Blended Learning, Synkron, online deltagelse, Mooc

    DEFF Research Database (Denmark)

    christiansen, rene b; Bichel, Rikke Aarestrup; Frimand, Anja

    2015-01-01

    Denne rapport er en afdækning af erfaringer, som undervisere og studerende ved pædagoguddannelsen på University College Sjælland (afdelingerne i Roskilde og Slagelse) gjorde sig omkring et forløb på uddannelsen, som blev udbudt i tre formater: blended undervisning, synkron, online undervisning og...

  13. Bog i besmrtnost – drugo i treće najvažnije pitanje

    OpenAIRE

    Djurić, Marko P.

    2013-01-01

    Autor u ovom članku sagledava pitanje o Bogu i pitanje o čovjekovoj besmrtnosti kao čovjekovo drugo i treće najvažnije pitanje. Pitanje o čovjekovoj sreći smatra prvim i najvažnijim. Prema njegovu shvaćanju sva tri pitanja međusobno se prožimlju, ne isključujući se. Bez vjere u objavljenog Boga i vjerovanja u vlastitu besmrtnost čovjek neće moći doživjeti najdublju i najpotpuniju sreću. Stoga se ovo izlaganje isključivo tiče eshatološkog vremena i budućnosti. Posljedica č...

  14. Introduction. Théâtre et révolutions

    OpenAIRE

    Bourdin, Philippe

    2012-01-01

    La réflexion his­­to­­rique, esthé­­tique, musicologique, théo­­rique et cri­­tique sur le théâtre de la Révo­­lu­­tion fran­­çaise a connu depuis le Bicen­­te­­naire une efflo­­res­­cence notoire. Plu­­ri­­dis­­cip­­li­­naire, asso­­ciant his­­to­­riens, his­­to­­riens de l’art, musi­­co­­logues et lit­­té­­raires, cette recherche a jeté ces der­­nières années des ponts solides de part et d’autre de l’Atlan­­tique, et déborde actuel­­le­­ment des fron­­tières fran­­çaises pour trou­­ver écho...

  15. Perturbed Newtonian description of the Lemaître model with non-negligible pressure

    International Nuclear Information System (INIS)

    Yamamoto, Kazuhiro; Marra, Valerio; Mukhanov, Viatcheslav; Sasaki, Misao

    2016-01-01

    We study the validity of the Newtonian description of cosmological perturbations using the Lemaître model, an exact spherically symmetric solution of Einstein's equation. This problem has been investigated in the past for the case of a dust fluid. Here, we extend the previous analysis to the more general case of a fluid with non-negligible pressure, and, for the numerical examples, we consider the case of radiation (P=ρ/3). We find that, even when the density contrast has a nonlinear amplitude, the Newtonian description of the cosmological perturbations using the gravitational potential ψ and the curvature potential φ is valid as long as we consider sub-horizon inhomogeneities. However, the relation ψ+φ=O(φ 2 )—which holds for the case of a dust fluid—is not valid for a relativistic fluid, and an effective anisotropic stress is generated. This demonstrates the usefulness of the Lemaître model which allows us to study in an exact nonlinear fashion the onset of anisotropic stress in fluids with non-negligible pressure. We show that this happens when the characteristic scale of the inhomogeneity is smaller than the sound horizon and that the deviation is caused by the nonlinear effect of the fluid's fast motion. We also find that ψ+φ= [O(φ 2 ),O(c s 2φ  δ)] for an inhomogeneity with density contrast δ whose characteristic scale is smaller than the sound horizon, unless w is close to −1, where w and c s are the equation of state parameter and the sound speed of the fluid, respectively. On the other hand, we expect ψ+φ=O(φ 2 ) to hold for an inhomogeneity whose characteristic scale is larger than the sound horizon, unless the amplitude of the inhomogeneity is large and w is close to −1

  16. Effets des sels organiques de tributyletain sur l'huître adulte Crassostrea gigas

    OpenAIRE

    Heral, Maurice; Alzieu, Claude; Caux, O.; Razet, Daniel; Garnier, Jacqueline

    1983-01-01

    La toxicité des composés organostanniques a été mise en évidence à l'égard de l'huître Crassostrea gigas tant aux stades larvaires (His & Robert, 1980) que chez l'adulte (Alzieu & al., 1980, 1981). Parallèlement ces mêmes auteurs ont montré l'accumulation d'étain dans les huîtres contaminées expérimentalement ainsi que le rôle que peut jouer le fluorure de TBT dans la perturbation de la croissance (Héral & al. 1981) et dans la malformation de la coquille des huîtres (Alzieu & al., 1981). Dans...

  17. Performance ReviewStories by Alice Munro: “The Office” and “Dolly”Théâtre Adyar, Paris, May 5

    OpenAIRE

    Bigot, Corinne

    2015-01-01

    Critique théâtrale, 5 mai 2015 Spectacle: Stories by Alice Munro “The Office” and “Dolly”: Théâtre Adyar, Paris 5 et 6 mai 2015 Theatre review, May 5th 2015 Show: Stories by Alice Munro: “The Office” and “Dolly”—May 5th & May 6th 2015

  18. Transfer Rate Edited experiment for the selective detection of Chemical Exchange via Saturation Transfer (TRE-CEST).

    Science.gov (United States)

    Friedman, Joshua I; Xia, Ding; Regatte, Ravinder R; Jerschow, Alexej

    2015-07-01

    Chemical Exchange Saturation Transfer (CEST) magnetic resonance experiments have become valuable tools in magnetic resonance for the detection of low concentration solutes with far greater sensitivity than direct detection methods. Accurate measures of rates of chemical exchange provided by CEST are of particular interest to biomedical imaging communities where variations in chemical exchange can be related to subtle variations in biomarker concentration, temperature and pH within tissues using MRI. Despite their name, however, traditional CEST methods are not truly selective for chemical exchange and instead detect all forms of magnetization transfer including through-space NOE. This ambiguity crowds CEST spectra and greatly complicates subsequent data analysis. We have developed a Transfer Rate Edited CEST experiment (TRE-CEST) that uses two different types of solute labeling in order to selectively amplify signals of rapidly exchanging proton species while simultaneously suppressing 'slower' NOE-dominated magnetization transfer processes. This approach is demonstrated in the context of both NMR and MRI, where it is used to detect the labile amide protons of proteins undergoing chemical exchange (at rates⩾30s(-1)) while simultaneously eliminating signals originating from slower (∼5s(-1)) NOE-mediated magnetization transfer processes. TRE-CEST greatly expands the utility of CEST experiments in complex systems, and in-vivo, in particular, where it is expected to improve the quantification of chemical exchange and magnetization transfer rates while enabling new forms of imaging contrast. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Transfer Rate Edited experiment for the selective detection of Chemical Exchange via Saturation Transfer (TRE-CEST)

    Science.gov (United States)

    Friedman, Joshua I.; Xia, Ding; Regatte, Ravinder R.; Jerschow, Alexej

    2015-07-01

    Chemical Exchange Saturation Transfer (CEST) magnetic resonance experiments have become valuable tools in magnetic resonance for the detection of low concentration solutes with far greater sensitivity than direct detection methods. Accurate measures of rates of chemical exchange provided by CEST are of particular interest to biomedical imaging communities where variations in chemical exchange can be related to subtle variations in biomarker concentration, temperature and pH within tissues using MRI. Despite their name, however, traditional CEST methods are not truly selective for chemical exchange and instead detect all forms of magnetization transfer including through-space NOE. This ambiguity crowds CEST spectra and greatly complicates subsequent data analysis. We have developed a Transfer Rate Edited CEST experiment (TRE-CEST) that uses two different types of solute labeling in order to selectively amplify signals of rapidly exchanging proton species while simultaneously suppressing 'slower' NOE-dominated magnetization transfer processes. This approach is demonstrated in the context of both NMR and MRI, where it is used to detect the labile amide protons of proteins undergoing chemical exchange (at rates ⩾ 30 s-1) while simultaneously eliminating signals originating from slower (∼5 s-1) NOE-mediated magnetization transfer processes. TRE-CEST greatly expands the utility of CEST experiments in complex systems, and in-vivo, in particular, where it is expected to improve the quantification of chemical exchange and magnetization transfer rates while enabling new forms of imaging contrast.

  20. Le fascisme, c’est du théâtre. Macchina scenica e meccanica narrativa

    Directory of Open Access Journals (Sweden)

    Emanuele Canzaniello

    2015-11-01

    Full Text Available «Le fascisme, c’est du théâtre», sostiene Jean Genet, e come tale i suoi legami con la natura e la prassi della messa in scena sono essenziali alla specificità del fenomeno. La resa spettacolare della nazionalizzazione delle masse è stata senz’altro tra i temi fondamentali della ricerca sui totalitarismi. Il mio proposito è qui quello di intarsiare alcuni nuclei consolidati della ricerca storica con le rese squisitamente letterarie di quello che fu poco più che un  decennio di immensi tableaux vivants, visioni di un nuovo ordine di massa. Un’opera d’arte collettiva, basata su una premessa  fondamentale: dare “figurabilità” ai detriti e alle rovine (rimosse? di alcuni miti delle origini propri della cultura romantica, e  consapevolmente avviare e mettere in luce un enorme processo più generale di disgregazione del logos e di tutta la civiltà europea nella sua prospettiva diremo cartesiana, geometrica e razionalista. Il mio discorso si fonda, anche se in breve, su un testo solo: la Gerbe des forces (1937 di A. de Châteaubriant, uno dei più singolari resoconti di pellegrinaggio politico verso il miraggio totalitario che si sia dato tre le due guerre mondiali. Soccorsi non secondari sono il saggio di Sontag Under the sign of Saturn (1980 e quello di Tame La Mystique du Fascisme dans l’oeuvre de Robert Brasillach (1986. According to Jean Genet: «Le fascisme, c’est du théâtre», and as such its relationship with the nature and praxis of staging are essential to the specificity of the phenomenon. The magnificent representation of mass nationalisation is beyond doubt one of the fundamental issues when investigating totalitarianisms. My aim here is to link some wellestablished nuclei of historical research to the literary outputs of what was little more than a decade of immense tableaux vivants, visions of a new mass order. A collective work of art, based on a fundamental premise: to give ‘figurality’ to the rubble

  1. Lemaître-Tolman-Bondi dust solutions in f (R) gravity

    Science.gov (United States)

    Sussman, Roberto A.; Jaime, Luisa G.

    2017-12-01

    We derive a class of non-static inhomogeneous dust solutions in f(R) gravity described by the Lemaître-Tolman-Bondi (LTB) metric. The field equations are fully integrated for all parameter subcases and compared with analogous subcases of LTB dust solutions of GR. Since the solutions do not admit regular symmetry centres, we have two possibilities: (i) a spherical dust cloud with angle deficit acting as the source of a vacuum Schwarzschild-like solution associated with a global monopole, or (ii) fully regular dust wormholes without angle deficit, whose rest frames are homeomorphic to the Schwarzschild-Kruskal manifold or to a 3d torus. The compatibility between the LTB metric and generic f(R) ansatzes furnishes an ‘inverse procedure’ to generate LTB solutions whose sources are found from the f(R) geometry. While the resulting fluids may have an elusive physical interpretation, they can be used as exact non-perturbative toy models in theoretical and cosmological applications of f(R) theories.

  2. Perturbed Newtonian description of the Lemaître model with non-negligible pressure

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Kazuhiro [Department of Physical Sciences, Hiroshima University, Higashi-hiroshima, Kagamiyama 1-3-1, 739-8526 (Japan); Marra, Valerio [Departamento de Física, Universidade Federal do Espírito Santo, Av. F. Ferrari, 514, 29075-910, Vitória, ES (Brazil); Mukhanov, Viatcheslav [Theoretical Physics, Ludwig Maxmillians University, Theresienstr. 37, 80333 Munich (Germany); Sasaki, Misao, E-mail: kazuhiro@hiroshima-u.ac.jp, E-mail: valerio.marra@me.com, E-mail: Viatcheslav.Mukhanov@physik.lmu.de, E-mail: misao@yukawa.kyoto-u.ac.jp [Yukawa Institute for Theoretical Physics, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502 (Japan)

    2016-03-01

    We study the validity of the Newtonian description of cosmological perturbations using the Lemaître model, an exact spherically symmetric solution of Einstein's equation. This problem has been investigated in the past for the case of a dust fluid. Here, we extend the previous analysis to the more general case of a fluid with non-negligible pressure, and, for the numerical examples, we consider the case of radiation (P=ρ/3). We find that, even when the density contrast has a nonlinear amplitude, the Newtonian description of the cosmological perturbations using the gravitational potential ψ and the curvature potential φ is valid as long as we consider sub-horizon inhomogeneities. However, the relation ψ+φ=O(φ{sup 2})—which holds for the case of a dust fluid—is not valid for a relativistic fluid, and an effective anisotropic stress is generated. This demonstrates the usefulness of the Lemaître model which allows us to study in an exact nonlinear fashion the onset of anisotropic stress in fluids with non-negligible pressure. We show that this happens when the characteristic scale of the inhomogeneity is smaller than the sound horizon and that the deviation is caused by the nonlinear effect of the fluid's fast motion. We also find that ψ+φ= [O(φ{sup 2}),O(c{sub s}{sup 2φ} δ)] for an inhomogeneity with density contrast δ whose characteristic scale is smaller than the sound horizon, unless w is close to −1, where w and c{sub s} are the equation of state parameter and the sound speed of the fluid, respectively. On the other hand, we expect ψ+φ=O(φ{sup 2}) to hold for an inhomogeneity whose characteristic scale is larger than the sound horizon, unless the amplitude of the inhomogeneity is large and w is close to −1.

  3. Christophe Couderc, dir., Le théâtre Espagnol du Siècle d'Or en France. De la traduction au transfert culturel

    Directory of Open Access Journals (Sweden)

    Christian Andrès

    2012-12-01

    Full Text Available Review of Christophe Couderc, Le théâtre Espagnol du Siècle d'Or en France. De la traduction au transfert culturel, Presses Universitaires de Paris Ouest, París, 2012, 299 pp. ISBN: 978-2-84016-102-8.

  4.  Spis treści

    Directory of Open Access Journals (Sweden)

    Mieczysław Dobija

    2014-04-01

    Ze współpracy z zagranicą .................................................................................. 145 Susana Callao, José I. Jarne, Dawid Wróblewski – Debates and studies on earnings management: a geographical perspective – Dyskusja na temat zarządzania zyskiem: perspektywa geograficzna ........... 145 4 Spis treści Darius Vaicekauskas, Jonas Mackevičius – Developing a framework for audit quality management in the audit firms –Ramy zarządzania jakością audytu w firmach audytorskich ........................ 171 Konferencje naukowe w dziedzinie rachunkowości i finansów organizowane w 2014 roku przez szkoły wyższe w Polsce ................................................... 195 Informacja dla autorów ....................................................................................... 199 Instructions for authors ....................................................................................... 207

  5. Le théâtre quantique l'horloge des anges ici-bas

    CERN Document Server

    Connes, Alain; Dixmier, Jacques

    2013-01-01

    Ce livre vous propose de pénétrer au coeur du théâtre quantique en vous offrant une voie d'accès rapide à l'univers magique de la mécanique quantique, découverte essentielle du XXe siècle qui défie notre intuition. Vous vous prendrez à rêver de ces photons capricieux, de leurs états intriqués, de ces expériences troublantes aux conclusions inattendues. Voici une fantaisie initiatique qui aborde de manière innovante le problème du temps, les paradoxes de la mécanique quantique et les interrogations sur la simulation des fonctions cérébrales, à travers une intrigue policière originale et les aventures d'une physicienne attachante, passionnée et prête à tout. Laissez-vous entraîner dans un monde enchanté où "l'aléa quantique est le tic-tac de l'horloge divine".

  6. Théâtre et Neuroscience: l’éveil d’un nouveau dialogue entre arts et science

    Directory of Open Access Journals (Sweden)

    Dorys Faria

    2014-05-01

    Full Text Available Cet article a pour but de démontrer, à travers une perspective historique, que l’étude neurophysiologique et expressive des émotions surgit en tant que vecteur facilitateur du dialogue entre le théâtre et les sciences du vivant. Font également partie de ce travail l’exploration de certains concepts neuroscientifiques actuellement utilisés dans la recherche expérimentale sur les émotions humaines, ainsi que la réflexion sur les liens possibles entre la neuroscience des émotions et le travail de l’acteur

  7. Global bifurcation of solutions of the mean curvature spacelike equation in certain Friedmann-Lemaître-Robertson-Walker spacetimes

    Science.gov (United States)

    Dai, Guowei; Romero, Alfonso; Torres, Pedro J.

    2018-06-01

    We study the existence of spacelike graphs for the prescribed mean curvature equation in the Friedmann-Lemaître-Robertson-Walker (FLRW) spacetime. By using a conformal change of variable, this problem is translated into an equivalent problem in the Lorentz-Minkowski spacetime. Then, by using Rabinowitz's global bifurcation method, we obtain the existence and multiplicity of positive solutions for this equation with 0-Dirichlet boundary condition on a ball. Moreover, the global structure of the positive solution set is studied.

  8. Sartre, en l’année de son centenaire : mauvais maître ou boussole éthique ?

    Directory of Open Access Journals (Sweden)

    Annie Cohen-Solal

    2007-06-01

    Full Text Available En France, peu de centenaires ont fait l’objet, comme celui de Sartre en 2005, d’une aussi négative unanimité. Hormis Les Temps Modernes et Libération (dont il fut le fondateur, pratiquement toute la presse colporta les mêmes clichés, en le stigmatisant en mauvais maître, en penseur démodé ou encore en imposteur. Le magazine L’Histoire reprit de vieilles insinuations, sans fondement scientifique, sur les occupations du philosophe pendant l’occupation nazie. Le Nouvel Observateur poursuivit la salve, avec le titre accrocheur de « Faut‐il brûler Sartre ? »

  9. Risøs treårsplan 2000-2002. Rullende 3-årsplan med hovedlinier for året 2000 og perspektiver for årene 2001 og 2002

    DEFF Research Database (Denmark)

    Forskningscenter Risø, Roskilde

    2000-01-01

    Denne treårsplan fastlægger rammerne for Forskningscenter Risøs virksomhed i perioden 2000 - 2002. Risø hører under Forskningsministeriet og driver naturvidenskabelig og teknisk-videnskabelig forskning med det formål at skabe nye udviklingsmuligheder forerhvervsliv og samfund rettet mod anvendels...

  10. Risøs treårsplan 1999-2001. Rullende 3-årsplan med hovedlinier for året 1999 og perspektiver for årene 2000 og 2001

    DEFF Research Database (Denmark)

    Forskningscenter Risø, Roskilde

    1999-01-01

    Denne treårsplan fastlægger rammerne for Forskningscenter Risøs virksomhed i perioden 1999-2001. Risø hører under Forskningsministeriet og driver naturvidenskabelig og teknisk-videnskabelig forskning med det formål at skabe nye udviklingsmuligheder forerhvervsliv og samfund rettet mod anvendelse ...

  11. Adaptations cinématographiques de pièces de théâtre à Lyon (1929-1939) : promotion mutuelle entre le théâtre des Célestins et les salles de cinéma

    OpenAIRE

    Marignan, Marylin

    2018-01-01

    Cet article propose de réexaminer la notion d’adaptation et de reprise, dans les années trente, à Lyon, non plus seulement en termes de « concurrence » entre le théâtre et le cinéma mais également en termes d’« emprunt », de « complémentarité » et de « promotion mutuelle ». Durant cette période, la presse diffuse largement l’idée que le cinéma, en se tournant davantage vers le répertoire théâtral ainsi que vers les dramaturges et les acteurs de l’art dramatique, avait fait un tort considérabl...

  12. Bilderboken ur ett genusperspektiv : En bilderboksanalys av tre svenska böcker som utmanar stereotypa könsroller

    OpenAIRE

    Malmqvist, Hanna

    2015-01-01

    Syftet med denna studie är att se hur några bilderböcker utmanar de stereotypa könsrollerna. Jag kommer att granska hur pojkar och flickor framställs ur ett genusperspektiv och även titta på hur text och bild kompletterar varandra, med hjälp av Nikolajevas (2000) analysmodell för bilderböcker. Jag har valt att analysera tre stycken böcker och två av dessa har pojkar som huvudkaraktärer och en har en flicka som huvudkaraktär. Med den medvetenhet man har idag kring genus så kan dessa böcker var...

  13. Autun (Saône-et-Loire. Étude archéologique du cloître canonial de Saint-Nazaire

    Directory of Open Access Journals (Sweden)

    Walter Berry

    2004-12-01

    Full Text Available L’année 2003, qui marquait à la fois les 20 ans de recherches entreprises à l’initiative de Christian Sapin et la fin des investigations de terrain, fut très fructueuse. En effet, outre une étude complémentaire de la zone occidentale du cloître, riche en découvertes, la galerie orientale qui a particulièrement retenu notre attention, recelait des informations capitales pour comprendre de façon plus précise l’histoire du site. À l’est, justement, d’autres parties d’une vaste habitation de l’An...

  14. Urojone-nic. Pojęcie zasady w Être, Monde, Imaginaire Stanislasa Bretona

    Directory of Open Access Journals (Sweden)

    Marcin POLAK

    2012-12-01

    Full Text Available A philosophical study of the concept of the principle was conducted by Stanislas Breton inhis two books: Du principe and Être, Monde Imaginaire, the first of which was dominated byits analytical and abstract style, while the second was speculative and imaginary. This articleundertakes the task of reconstructing the idea of the principle contained in the latter position.In the first part of the article the author presents two currents of thought concerning theprinciple: the ontological, which is based on the category of logos, and the ontomythological,for which the leading category is mythos. After discussing the differences between these twofields of thought and their corresponding fields of being, the author undertakes an attempt atdescribing the absolute source of reality – imaginary-nothing. The attempt is accompanied bya presentation of the way in which the ineffable principle produces the Word, whose originalexpression is prattle. The article concludes with an analysis of fable as the original form of expressionof the imaginary-nothing, from which arise the two trunks of rationality mentionedabove: the ontological and the ontomythological.

  15. La métaplasie osteoide de l'endomètre après une grossesse à terme: à propos d'un cas rare

    Science.gov (United States)

    Jayi, Sofia; Bouguern, Hakima; Fatemi, Hind; Chaara, Hikmat; Laamarti, Afaf; Melhouf, Aabdelilah

    2013-01-01

    La métaplasie ostéoïde de l'endomètre (MOE) est une entité rare correspondant à la présence de tissu osseux dans l'endomètre, elle est le plus souvent diagnostiquée dans un contexte d'infertilité secondaire faisant suite à une grossesse interrompue. Même si plusieurs facteurs de risque sont répertoriés, sa physiopathologie reste mal connue et sa traduction clinique est très variable. Nous rapportons un cas de MOE apparu suite à un curetage pour rétention placentaire en post-partum. Le diagnostic a été suspecté par l'hystéroscopie et confirmé par l’étude anatomopathologique. A notre connaissance c'est le premier cas décrit suite à un accouchement à terme. A travers notre cas et à la lumière d'une revue de la littérature nous insistons sur les caractéristiques épidémiologiques, physiopathologiques, cliniques et para cliniques de cette entité rare, dont la connaissance est primordiale pour un diagnostic sûr et par conséquent un traitement adapté permettant souvent de récupérer la fertilité de la patiente. PMID:23898363

  16. Noise Training - ’Bruit – Connaître les risques liés au bruit‘

    CERN Multimedia

    HR Department

    2010-01-01

    Several sessions of the ‘Bruit – Connaître les risques liés au bruit’ course will be held in February 2010. This course is intended for the members of the personnel who are exposed to the noise on a regular basis or punctually, and, in priority to those persons who wear hearing protections. The objective of the training is to explain: That noise is a progressive evil, not painful but with irreversible effects That the only effective action to preserve his hearing is prevention through protection Programme of the course: Noise in the workplace: localization of noisy places; Analysis of a questionnaire: questions and answers; Noise: definitions and elementary notions; How the hearing works; The effects of noise on hearing; The audiogram; The individual hearing protection; How to gradually get used to hearing protection? Duration: 2h30 Language: English or French To subscribe, please create a training request on EDH...

  17. Atbildība pret trešajām personām būvniecībā un par ekspluatācijā esošu būvi

    OpenAIRE

    Zalamane, Adele

    2015-01-01

    Maģistra darba tēma ir civiltiesiskā atbildība pret trešajām personām par aizskārumu, kura pamatā ir būvniecības laikā pieļautas kļūdas. Darba mērķis ir noskaidrot pastāvošo regulējumu, apzināt tā trūkumus un piedāvāt risinājumus. Lai izpētītu civiltiesiskās atbildības regulējumu pret trešajām personām, ievērojot nesenos normatīvo aktu grozījumus būvniecības nozarē, izpētīts atbildības regulējums Būvniecības likumā, kurš bija spēkā līdz 2014.gada 1.oktobrim, un jaunajā Būvniecības likumā. ...

  18. Marins, terriens et touristes sur la côte d’Albâtre: «renoncer, moi? jamais!»

    Directory of Open Access Journals (Sweden)

    Barbara Evrard

    2009-10-01

    Full Text Available L’objectif de cet article est de montrer et de questionner la territorialisation de la Côte d’Albâtre à partir des expériences corporelles qui s’y déploient. Ce littoral, à première vue peu propice au développement des loisirs, sert pourtant de «terrain de jeu» à quelques pratiquants d’activités de nature. Nous cherchons à mieux comprendre dans quelle mesure les activités de nature participent de la production d’usages et d’images constitutifs de médiation(s territoriale(s et d’identité maritime spécifique à la Haute-Normandie et dans le même temps distincte de celle des non pratiquants.

  19. Funcionalidad de Juegos de Estrategia Virtuales y del Software Cabri-géomètre II en el Aprendizaje de la Simetría en Secundaria

    Directory of Open Access Journals (Sweden)

    Guadalupe Rodríguez

    2010-06-01

    Full Text Available Presentamos resultados de un estudio exploratorio cuyo propósito es indagar sobre el uso del Cabri-Géomètre II y de un juego matemático virtual de estrategia cuando se incluyen en clases ordinarias de matemáticas de estudiantes de 12-13 años en una escuela secundaria pública de México. Para este trabajo, el tema abordado fue la simetría. El análisis de datos permitió ver la funcionalidad de estos ambientes para transformar las nociones del alumno sobre el tema y para reconocer que se puede avanzar en el desarrollo de un pensamiento matemático distinto a través de ambientes de aprendizaje computacionales. We present the results of an exploratory study whose purpose was to explore the use by 12-13 years old students of Cabri-Géomètre II and a mathematical strategic virtual game in a Mexican state school. For this paper, the mathematical focus was on symmetry. The data analysis allowed us to observe the functionality of this learning environment to transform the students’ conceptions and to recognize that a different type of mathematical thinking can be developed with these computational learning environments.

  20. Après le postdramatique : narration et fiction entre écriture de plateau et théâtre néo-dramatique

    Directory of Open Access Journals (Sweden)

    Anne Monfort

    2009-12-01

    Full Text Available Dans le théâtre contemporain, que ce soit en France ou en Allemagne, la notion de récit intervient dans la représentation traditionnelle théâtrale, introduisant une redéfinition de la fiction et de l’acteur.Im zeitgenössischen Theater, sei es in Frankreich oder in Deutschland, werden Erzählung und herkömmliche Bühnendarstellung in Korrelation gebracht, wobei der Begriff der Fiktion sowie die Rolle des Schauspielers als Handlungsträger neu definiert werden.

  1. Anne-Hélène Pitel, Le prosimètre dans l’oeuvre de fiction de Lope de Vega, de «La Arcadia» (1598 à «La Dorotea» (1632

    Directory of Open Access Journals (Sweden)

    Javier Rubiera

    2013-05-01

    Full Text Available Review of Anne-Hélène Pitel, Le prosimètre dans l’oeuvre de fiction de Lope de Vega, de «La Arcadia» (1598 à «La Dorotea» (1632, Editorial Academia del Hispanismo, Vigo, 2011, 400 pp. ISBN: 978-84-96915-98-5.

  2. Caroline Surmann, Cinéma et théâtre chez Jean Cocteau. Intermédialité et esthétique

    OpenAIRE

    Brangé, Mireille

    2016-01-01

    Dans une démarche artistique considérée comme essentiellement multimédiale et «déambulant entre les arts» (p. 12), la relation établie entre cinéma et théâtre par Cocteau est un terrain de choix pour envisager sa pratique intermédiale. L’A. précise ce concept travaillé d’abord en Allemagne et au Canada et le plus souvent seulement approché en France, et offre une introduction théorique appréciable (pp. 13-15; 47-67) en l’absence, à notre connaissance, de toute traduction française des textes ...

  3. Ricci time in the Lemaître-Tolman model and the block universe

    Science.gov (United States)

    Elmahalawy, Yasser; Hellaby, Charles; Ellis, George F. R.

    2015-10-01

    It is common to think of our universe according to the "block universe" concept, which says that spacetime consists of many "stacked" three-surfaces, labelled by some kind of proper time, . Standard ideas do not distinguish past and future, but Ellis' "evolving block universe" tries to make a fundamental distinction. One proposal for this proper time is the proper time measured along the timelike Ricci eigenlines, starting from the big bang. This work investigates the shape of the "Ricci time" surfaces relative to the the null surfaces. We use the Lemaître-Tolman metric as our inhomogeneous spacetime model, and we find the necessary and sufficient conditions for these constant surfaces, , to be spacelike or timelike. Furthermore, we look at the effect of strong gravity domains by determining the location of timelike S regions relative to apparent horizons. We find that constant Ricci time surfaces are always spacelike near the big bang, while at late times (near the crunch or the extreme far future), they are only timelike under special circumstances. At intermediate times, timelike S regions are common unless the variation of the bang time is restricted. The regions where these surfaces become timelike are often adjacent to apparent horizons, but always outside them, and in particular timelike S regions do not occur inside the horizons of black-hole-like models.

  4. TYPHLOREICHEIA DELLA SARDEGNA: DESCRIZIONE DI TRE NUOVI TAXA E DATI GEONEMICI INEDITI (COLEOPTERA, CARABIDAE

    Directory of Open Access Journals (Sweden)

    Paolo Magrini

    2007-10-01

    Full Text Available Nella presente nota vengono descritti tre nuovi taxa di Typhloreicheia Holdhaus, 1924 del Sud della Sardegna e riportati nuovi dati geonemici relativi a Typhloreicheia degiovannii Magrini, 2003 e Typhloreicheia raymondi (Putzeys, 1869. T. petriolii n. sp. di Monte Idda (San Priamo, Muravera, Cagliari, appartenente al “gruppo occulta”, sensu Magrini & Bulirsch 2002, diversa da tutte le altre specie del gruppo per l’edeago meno incurvato ventralmente, l’apice meno inflesso, la lamella copulatrice più corta e ristretta apicalmente anziché dilatata. T. abbazzii n. sp. di Arbus (San Gavino Monreale, Medio Campidano, caratterizzata da un edeago con apice fortemente ricurvo ventralmente e lamella copulatrice costituita da grosse spine evanescenti posizionate lungo il margine inferiore dell’apice dell’edeago, caratteri che pongono la nuova specie in posizione isolata nell’ambito del genere. T. leoi pilosa n. ssp. del Parco di Monte Marganai, loc. Mamenga (Carbonia-Iglesias, appartenente al “gruppo angelae”, sensu Magrini 2003. La nuova razza si differenzia dalla forma tipica essenzialmente per la morfologia esterna: presenza di setole discali elitrali su tutte le interstrie (dalla due alla sette, solo nelle interstrie 3-5-7 nella forma tipica e per l’habitus nettamente più dilatato, specialmente a livello delle elitre, come indicano le misure riportate nel testo.

  5. Optimisation and validation of a remote monitoring system (Onco-TreC) for home-based management of oral anticancer therapies: an Italian multicentre feasibility study.

    Science.gov (United States)

    Passardi, Alessandro; Rizzo, Mimma; Maines, Francesca; Tondini, Carlo; Zambelli, Alberto; Vespignani, Roberto; Andreis, Daniele; Massa, Ilaria; Dianti, Marco; Forti, Stefano; Piras, Enrico Maria; Eccher, Claudio

    2017-05-29

    Despite the growing number of oral agents available for cancer treatment, their efficacy may be reduced due to the lack of adherence, inappropriate adverse event self-management and arbitrary dose adjustment. The management of anticancer therapies could exponentially benefit from the introduction of mobile health technologies in a highly integrated electronic oncology system. We plan to customise and fine-tune an existing monitoring TreC platform used in different chronic diseases in the oncology setting. This project follows a multistep approach with two major purposes: 1. participatory design techniques driven by Health Literacy and Patient Reported Outcomes principles in order to adapt the system to the oncology setting involving patients and healthcare providers; 2. a prospective training-validation, interventional, non-pharmacological, multicentre study on a series of consecutive patients with cancer (20 and 60 patients in the training and validation steps, respectively) in order to assess system capability, usability and acceptability. The novel Onco-TreC 2.0 is expected to contribute to improving the adherence and safety of cancer care, promoting patient empowerment and patient-doctor communication. Ethical approval was obtained from the Independent Ethics Committees of the participating institutions (CEIIAV protocol Number 2549/2015; reference Number 1315-PU). Informed consent will be obtained from all study participants. Findings will be disseminated through peer-reviewed journals, conferences and event presentations. ClinicalTrials.gov (NCT02921724); (Pre-results). Other study ID Number: IRST100.18. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  6. Influence of a trout farm on macrozoobenthos communities of the Trešnjica river, Serbia

    Directory of Open Access Journals (Sweden)

    Živić Ivana

    2009-01-01

    Full Text Available Trout farming poses an increasing threat to quality of the water of clean highland streams. Research of this problem has focused primarily on changes in physico-chemical composition of the water and structure of the river bottom, and less on the effects on living organisms. In the present work, we investigated influence of the farm with the highest trout production in Serbia, the 'Riboteks' Trout Farm on the Trešnjica River, on its macrozoobenthos communities. Our investigations showed that the 'Riboteks' Trout Farm wastewaters caused a clear and statistically significant change of moderate intensity in all measured parameters describing the composition and structure of macrozoobenthos communities. These changes were most pronounced in the part of the watercourse closest to the influx of waste water (locality III but remained statistically significant even 500 m downstream (locality IV and were lost only about 3.5 km away from the influx of the farm's wastewater (locality V. The most pronounced were changes in the participation in total abundance of the Baetidae, Chironomidae, and Plecoptera. Additionally, results of the present work confirmed that the mass of fish on the trout farm is a parameter that adequately defines the strength of its action, above all the intensity of its influence on structure of the macrozoobenthos community.

  7. Compréhension des mécanismes de séchage dans les matériaux de construction : cas du plâtre

    OpenAIRE

    SECK, Mamadou Diaga

    2015-01-01

    Les enjeux liés aux problématiques de développement durable encouragent de plus en plus d'industriels, dans le secteur du bâtiment, à se lancer dans une politique de réduction de la consommation énergétique de leurs procédés industriels. C'est dans ce cadre qu'est menée cette étude, où nous nous intéressons au cas particulier de la fabrication des plaques de plâtre, qui de par les qualités qu'elles présentent liées à leur caractère pratique et rapide à poser (temps pour le neuf que la rénovat...

  8. Integracija digitalne radio-difuzne mreže mobilne televizije i ćelijske mreže treće generacije

    Directory of Open Access Journals (Sweden)

    Milan Manojle Šunjevarić

    2013-02-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 U radu su prikazani rezultati istraživanja mogućnosti za integraciju radio-difuznih mreža za mobilnu televiziju i ćelijskih mreža treće generacije (3G. Analizirani su trendovi u pogledu razvoja usluge mobilne televizije, i dosadašnja istraživanja koja imaju za cilj traženje optimalnih načina za integraciju različitih tipova mreža. U radu su analizirane postojeće tehnologije za mobilnu televiziju, s posebnim osvrtom na DVB-H (Digital Video Broadcasting - Handheld tehnologiju. Analizirani su preduslovi, razlozi i mogućnosti za integraciju DVB-H i 3G mreže UMTS (Universal Mobile Telecommunications System, a zaključci ovih analiza su potkrepljeni rezultatima praktičnog rada. Na osnovu svih ovih istraživanja donesen je zaključak o opravdanosti realizacije hibridne DVB-H/UMTS mreže.

  9. A 'college of astrology and medicine'? Charles V, Gervais Chrétien, and the scientific manuscripts of Maître Gervais's College.

    Science.gov (United States)

    Boudet, Jean-Patrice

    2010-06-01

    Considered an institution mainly devoted to astrology and medicine by Simon de Phares and by some historians who believe that he was reliable, the college founded in 1371 by Charles V's first physician, Gervais Chrétien, was in fact primarily dedicated to theological students. It was not before 1377 that there were created there two bursaries for scholares regis, specialising in 'licit mathematical sciences', and two medical fellowships. Yet the influence of the activity of these fellows seems to have been rather moderate and-as far as we can learn from the material still extant, notably from manuscripts that belonged to Maître Gervais' College and to some of its members-this institution was devoted much more to theological studies than to medicine and the quadrivium.

  10. Tragédie et comédie : deux représentations de la pauvreté et de la marginalité dans le théâtre acadien contemporain

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    Denis Bourque

    2012-05-01

    Full Text Available Le théâtre acadien contemporain est né de façon fulgurante avec une mise en scène à la fois tragique et comique de la pauvreté et de la marginalité sociale. Pour la première fois en Acadie, Antonine Maillet, dans Les Crasseux et La Sagouine : Pièce pour une femme seule, donnait, dans leur langage propre, la parole aux miséreux, aux exclus, aux parias de la société. Cette représentation de la pauvreté et de la marginalité comme étant à la fois tragique et comique s’est poursuivie dans le théâtre acadien. On la retrouve dans la pièce Le Djibou de Laval Goupil, par exemple, créée en 1975 et réécrite pour une nouvelle représentation en 1997 sous le titre de Le Djibou ou l’Ange déserteur. Dans les années 2000, Herménégilde Chiasson et Marcel-Romain Thériault reprendront ce thème de la pauvreté et de la marginalité en Acadie, Chiasson le fait de façon directe et comique dans Laurie ou la vie de galerie (2002, puis de façon tragique dans Le Christ est apparu au Gun Club (2005 ; Thériault, pour sa part, n’accorde la parole à ceux-ci que de façon indirecte et tragique dans Le filet : Une tragédie maritime (2009.

  11. SOLUȚIONAREA „CHESTIUNII ARMENEȘTI” DE CĂTRE GUBERNATORUL BASARABIEI S.D. URUSOV (1903-1904

    Directory of Open Access Journals (Sweden)

    Valentin ARAPU

    2017-08-01

    Full Text Available Gubernatorul Basarabiei S.D. Urusov a soluționat „chestiunea armenească” pe cale amiabilă. Armenii basarabeni au acceptat să cedeze statului rus o parte din bani și proprietăți, păstrându-și intacte privilegiile și statutul de odinioară. În Basarabia, spre deosebire de alte gubernii în care au existat tensiuni în acest sens, grație unei politici abile și tolerante, promovate față de armeni de către S.D. Urusov, procesul de expropriere parțială a comunității armenești s-a desfășurat calm și fără excese.SETTLEMENT OF THE „ARMENIAN ISSUE” BY THE GOVERNOR OF BESSARABIA S.D. URUSOV (1903-1904The governor of Bessarabia S.D. Urusov settled the „Armenian issue” in an amicable way. Armenians from Bessarabiaagreed to cede to Russian state some money and properties, in order to keep intact the privileges and status they held. In Bessarabia, unlike other gubernias, where there were tensions in this regard, thanks to skilful and tolerant policy, promoted by S.D. Urusov, the process of partial expropriation of the Armenian community was held calmly and without excesses.

  12. Disparaître dans la fiction. La traversée du miroir du Docteur Pasavento

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    Charline Pluvinet

    2010-09-01

    Full Text Available Cet article s’attache à explorer dans Docteur Pasavento les modalités et les enjeux d’une réinvention fictionnelle de soi qui se déploie selon un dispositif complexe : le personnage éponyme, qui orchestre sa propre disparition pour se donner de nouvelles identités fictives, est lui-même une projection de l’écrivain. Se réalise dans le roman une alliance entre l’aspiration à disparaître et le désir de rendre indistinctes fiction et réalité, que nous proposons d’éclairer par la métaphore carrollienne de la traversée du miroir où ces mouvements se conjuguent. Il s’agira de rendre perceptible la dynamique fictionnelle qui anime l’écriture romanesque d’Enrique Vila-Matas. This article endeavours to explore the stakes and modalities of the fictional re-invention of the self that takes place in Docteur Pasavento.In the novel, this reinvention arranges itself in accordance to a complex scheme : by orchestrating his own disappearance in order to confer upon himself new fictitious identities, the eponymous character of the novel becomes a projection of the author himself. In the novel, the aspiration to disappear is thus unified with a desire to blur the boundaries between fiction and reality. I intend to shed light on this union by invoking the Carrollian metaphor of passing “through the looking-glass”. The intention of this article is to render evident the fictional dynamism that underpins the novelistic writings of Enrique Vila-Matas.

  13. Cosmology of a Friedmann-Lamaître-Robertson-Walker 3-brane, late-time cosmic acceleration, and the cosmic coincidence.

    Science.gov (United States)

    Doolin, Ciaran; Neupane, Ishwaree P

    2013-04-05

    A late epoch cosmic acceleration may be naturally entangled with cosmic coincidence--the observation that at the onset of acceleration the vacuum energy density fraction nearly coincides with the matter density fraction. In this Letter we show that this is indeed the case with the cosmology of a Friedmann-Lamaître-Robertson-Walker (FLRW) 3-brane in a five-dimensional anti-de Sitter spacetime. We derive the four-dimensional effective action on a FLRW 3-brane, from which we obtain a mass-reduction formula, namely, M(P)(2) = ρ(b)/|Λ(5)|, where M(P) is the effective (normalized) Planck mass, Λ(5) is the five-dimensional cosmological constant, and ρ(b) is the sum of the 3-brane tension V and the matter density ρ. Although the range of variation in ρ(b) is strongly constrained, the big bang nucleosynthesis bound on the time variation of the effective Newton constant G(N) = (8πM(P)(2))(-1) is satisfied when the ratio V/ρ ≳ O(10(2)) on cosmological scales. The same bound leads to an effective equation of state close to -1 at late epochs in accordance with astrophysical and cosmological observations.

  14. O sednie terminu „social media”. „Web 2.0” a sprawność użytkowników w „generowaniu treści”.

    OpenAIRE

    Toczyski, Piotr

    2014-01-01

    Wychodząc od ilościowego nadmiaru definicji „social media” i zarazem ich niedoboru pod względem jakości, wykonuję przegląd definicji tego pojęcia od 1896 roku. Okazuje się, że terminem „social media” w naukach społecznych posługiwano się już na ponad sto lat przed internetem. Współczesne rozstrzygnięcia definicyjne rozbijają się nie tylko o kompetencje definiujących „social media”, ale także o takie pojęcia jak „treść”, „użytkownik”, „społeczność” czy „Web 2.0” oraz ich wzajemne relacje w śro...

  15. Phenomenological constraints on Lemaître-Tolman-Bondi cosmological inhomogeneities from solar system dynamics

    Science.gov (United States)

    Iorio, Lorenzo

    2010-06-01

    We, first, analytically work out the long-term, i.e. averaged over one orbital revolution, perturbations on the orbit of a test particle moving in a local Fermi frame induced therein by the cosmological tidal effects of the inhomogeneous Lemaître-Tolman-Bondi (LTB) model. The LTB solution has recently attracted attention, among other things, as a possible explanation of the observed cosmic acceleration without resorting to dark energy. Then, we phenomenologically constrain both the parameters K1 doteq ddot frakR / frakR and K2 doteq ddot frakR' / frakR' of the LTB metric in the Fermi frame by using different kinds of solar system data. The corrections Δdot varpi to the standard Newtonian/Einsteinian precessions of the perihelia of the inner planets recently estimated with the EPM ephemerides, compared to our predictions for them, yield preliminarily K1 = (4±8) × 10-26 s-2, K2 = (3±7) × 10-23 s-2. The residuals of the Cassini-based Earth-Saturn range, compared with the numerically integrated LTB range signature, allow to preliminarily obtain K1 approx K2 approx 10-27 s-2. Actually, the LTB effects should be explicitly modeled in the ephemerides softwares, so that the entire planetary and spacecraft data sets should be accordingly re-processed. The LTB-induced distortions of the orbit of a typical object of the Oort cloud with respect to the commonly accepted Newtonian picture, based on the observations of the comet showers from that remote region of the solar system, point towards K1 approx K2lesssim10-30-10-32 s-2. Such figures have to be compared with those inferred from cosmological data which are of the order of K1 approx K2 = -4 × 10-36 s-2.

  16. The iTreAD project: a study protocol for a randomised controlled clinical trial of online treatment and social networking for binge drinking and depression in young people.

    Science.gov (United States)

    Kay-Lambkin, F J; Baker, A L; Geddes, J; Hunt, S A; Woodcock, K L; Teesson, M; Oldmeadow, C; Lewin, T J; Bewick, B M; Brady, K; Spring, B; Deady, M; Barrett, E; Thornton, L

    2015-10-06

    Depression and binge drinking behaviours are common clinical problems, which cause substantial functional, economic and health impacts. These conditions peak in young adulthood, and commonly co-occur. Comorbid depression and binge drinking are undertreated in young people, who are reluctant to seek help via traditional pathways to care. The iTreAD project (internet Treatment for Alcohol and Depression) aims to provide and evaluate internet-delivered monitoring and treatment programs for young people with depression and binge drinking concerns. Three hundred sixty nine participants will be recruited to the trial, and will be aged 18-30 years will be eligible for the study if they report current symptoms of depression (score 5 or more on the depression subscale of the Depression Anxiety Stress Scale) and concurrent binge drinking practices (5 or more standard drinks at least twice in the prior month). Following screening and online baseline assessment, participants are randomised to: (a) online monthly self-assessments, (b) online monthly self-assessments + 12-months of access to a 4 week online automated cognitive behaviour therapy program for binge drinking and depression (DEAL); or (c) online monthly assessment + DEAL + 12-months of access to a social networking site (Breathing Space). Independent, blind follow-up assessments occur at 26, 39, 52 and 64-weeks post-baseline. The iTreAD project is the first randomised controlled trial combining online cognitive behaviour therapy, social networking and online monitoring for young people reporting concerns with depression and binge drinking. These treatments represent low-cost, wide-reach youth-appropriate treatment, which will have significantly public health implications for service design, delivery and health policy for this important age group. Australian and New Zealand Clinical Trials Registry ACTRN12614000310662. Date registered 24 March 2014.

  17. La maison bourgeoise en milieu rural : de la maison de maître à la résidence secondaire. Préhistoire des campagnes periurbaines (début XIXe-1970)

    OpenAIRE

    Thébault, Vincent

    2015-01-01

    L'importance et la diffusion du bâti bourgeois en milieu rural demeure une des questions les moins explorées du paysage social des campagnes françaises contemporaines. Dans un essai de géographie du capital foncier, Louis Bergeron notait que le xixe siècle n'était pas seulement celui de la reconstruction et de la multiplication des châteaux, mais aussi des maisons de maître et des bâtiments d'exploitation dont l'allure et les matériaux témoignent d'un nouvel aménagement, plus capitalistique,...

  18. Bilans w warunkach utraty kontynuacji działalności– zasada ostrożności czy treść ekonomiczna

    Directory of Open Access Journals (Sweden)

    Ewa Walińska

    2009-10-01

    Full Text Available Przedmiotem rozważań w niniejszym artykule są obecnie obowiązujące zasady sporządzania bilansu przedsiębiorstwa, które straciło zdolność do kontynuacji działalności z powodu postępowania upadłościowego. Bilans likwidacyjny rozpoczyna ostatni cykl życia przedsiębiorstwa – zakończenie jego działalności. W tym okresie zmieniają się cele działalności gospodarczej: jedynym celem staje się sprzedaż jego majątku. Brak zasady kontynuacji działalności przedsiębiorstwa upoważnia, zdaniem autorów, do odstępstw od pewnych zasad rachunkowości, głównie ostrożności, na rzecz zasady treści ekonomicznej. Takie odstępstwo realizuje zapisaną w prawie bilansowym koncepcję true and fair. W artykule postuluje się przyjęcie do wyceny majątku w bilansie likwidacyjnym wartości zbywczej niezależnie od tego, czy jest ona wyższa, czy niższa od jego wartości księgowej.

  19. La variabilité génétique chez l'huître plate Ostrea edulis (L. 1758) : inférence du nombre de géniteurs instantané d'une population

    OpenAIRE

    Da Silva, Sara Maria Mira

    2001-01-01

    Les études de génétique des populations des bivalves marins ont fréquemment mit en évidence une relation hétérozygotie / valeur sélective, et un fort déficit en hétérozygotes. Parmi les hypothèses explicatives de ces deux phénomènes, la création d'individus consanguins dans les populations est particulièrement intéressante à tester. Le but de ce travail était de vérifier s'il pouvait y avoir un nombre faible de géniteurs à la base d'un événement de reproduction donné chez l'huître plate Ostre...

  20. La chiesa di Richard Meier a Tor Tre Teste e il suo contributo al consolidamento identitario dei nuovi quartieri romani oltre il GRA / The church designed by Richard Meier in Tor Tre Teste and the identity consolidation in the new roman neighbourhoods beyond the Great Circular Road

    Directory of Open Access Journals (Sweden)

    Giuseppe Bonaccorso

    2014-06-01

    Full Text Available Il contributo proposto ha l’obiettivo di analizzare alcuni significativi brani del tessuto urbano della periferia est di Roma, adottando metodi interpretativi legati alla storia, alla società, alla programmazione urbanistica e alla costruzione. Gli aspetti salienti del quadrante orientale della periferia romana verranno così delineati partendo “dal di dentro”, sottolineandone i percorsi, gli spazi e i nuclei compositivi che sono all’origine della struttura e della forma stessa dei quartieri disposti a cavallo del Grande Raccordo Anulare. In questo ambito, si pone l’attenzione su alcuni episodi chiave che vedono protagoniste le nuove chiese che riescono a creare una centralità all’interno dei quartieri periferici sostituendo le biblioteche, le piazze e i centri commerciali.  Analizzando da vicino questi esempi, si scopre come di recente sono state realizzate chiese firmate da architetti di fama internazionale proprio allo scopo di rafforzare, o meglio di costruire, un fattore identitario per ciascun quartiere ubicato nel settore orientale della città. Partendo quindi dal generale si arriva a indagare una chiesa e un quartiere che possono essere considerati un modello da seguire per tutta la periferia a ridosso del GRA: la chiesa giubilare di Dio Padre Misericordioso progettata da Richard Meier nel quartiere di Tor Tre Teste. La sequenzialità degli eventi che hanno contraddistinto il concorso per la progettazione della chiesa, la scelta della proposta di Richard Meier, la complessità del cantiere, l’analisi tecnica, stilistica e simbolica della realizzazione finale sono quindi analizzate nell’ambito del rapporto con il quartiere e del tentativo di realizzare (attraverso di essa un centro di attrazione per tutta la periferia.   The article analyses some significant parts of the urban tissue at the eastern periphery of Rome, using the interpretative methods inherent to history, society, urban programming and construction

  1. A (giant) void is not mandatory to explain away dark energy with a Lemaître-Tolman model

    Science.gov (United States)

    Célérier, M.-N.; Bolejko, K.; Krasiński, A.

    2010-07-01

    Context. Lemaître-Tolman (L-T) toy models with a central observer have been used to study the effect of large scale inhomogeneities on the SN Ia dimming. Claims that a giant void is mandatory to explain away dark energy in this framework are currently dominating. Aims: Our aim is to show that L-T models exist that reproduce a few features of the ΛCDM model, but do not contain the giant cosmic void. Methods: We propose to use two sets of data - the angular diameter distance together with the redshift-space mass-density and the angular diameter distance together with the expansion rate - both defined on the past null cone as functions of the redshift. We assume that these functions are of the same form as in the ΛCDM model. Using the Mustapha-Hellaby-Ellis algorithm, we numerically transform these initial data into the usual two L-T arbitrary functions and solve the evolution equation to calculate the mass distribution in spacetime. Results: For both models, we find that the current density profile does not exhibit a giant void, but rather a giant hump. However, this hump is not directly observable, since it is in a spacelike relation to a present observer. Conclusions: The alleged existence of the giant void was a consequence of the L-T models used earlier because their generality was limited a priori by needless simplifying assumptions, like, for example, the bang-time function being constant. Instead, one can feed any mass distribution or expansion rate history on the past light cone as initial data to the L-T evolution equation. When a fully general L-T metric is used, the giant void is not implied.

  2. Characterization and expression patterns of a membrane-bound trehalase from Spodoptera exigua

    Directory of Open Access Journals (Sweden)

    Xu Weihua

    2008-05-01

    Full Text Available Abstract Background The chitin biosynthesis pathway starts with trehalose in insects and the main functions of trehalases are hydrolysis of trehalose to glucose. Although insects possess two types, soluble trehalase (Tre-1 and membrane-bound trehalase (Tre-2, very little is known about Tre-2 and the difference in function between Tre-1 and Tre-2. Results To gain an insight into trehalase functions in insects, we investigated a putative membrane-bound trehalase from Spodoptera exigua (SeTre-2 cloned from the fat body. The deduced amino acid sequence of SeTre-2 contains 645 residues and has a predicted molecular weight of ~74 kDa and pI of 6.01. Alignment of SeTre-2 with other insect trehalases showed that it contains two trehalase signature motifs and a putative transmembrane domain, which is an important characteristic of Tre-2. Comparison of the genomic DNA and cDNA sequences demonstrated that SeTre-2 comprises 13 exons and 12 introns. Southern blot analysis revealed that S. exigua has two trehalase genes and that SeTre-2 is a single-copy gene. Northern blot analyses showed that the SeTre-2 transcript is expressed not only in the midgut, as previously reported for Bombyx mori, but also in the fat body and Malpighian tubules, although expression patterns differed between the midgut and fat body. SeTre-2 transcripts were detected in the midgut of feeding stage larvae, but not in pupae, whereas SeTre-2 mRNA was detected in the fat body of fifth instar larvae and pupae. Conclusion These findings provide new data on the tissue distribution, expression patterns and potential function of membrane-bound trehalase. The results suggest that the SeTre-2 gene may have different functions in the midgut and fat body.

  3. Trehalose 6-phosphate signal is closely related to sorbitol in apple (Malus domestica Borkh. cv. Gala

    Directory of Open Access Journals (Sweden)

    Wen Zhang

    2017-02-01

    Full Text Available Trehalose-6-phosphate (Tre6P is a precursor of trehalose, which is widespread in nature and greatly influences plant growth and development. Tre6P acts as a signal of carbon availability in many plants, but little is known about the function of Tre6P in rosaceous plants, which have specific sorbitol biosynthesis and transportation pathways. In the present study, Tre6P levels and Sorbitol:Tre6P ratios were analyzed in apple (Malus domestica, Borkh. cv. Gala. Tre6P levels were positively correlated with sorbitol content but negatively correlated with sucrose, glucose, and fructose content in developing fruit. However, under sorbitol-limited conditions, Tre6P levels were positively correlated with both sorbitol and sucrose. In the presence of different exogenous sugar supply, Tre6P levels increased corresponding with sorbitol, but this was not the case with sucrose. In addition, Tre6P content and sorbitol:Tre6P ratios were more highly correlated with ADP-glucose levels under sorbitol-limited conditions and fruit development stages, respectively. These results suggest that Tre6P is more closely related to sorbitol than other soluble sugars and has an important role in influencing carbon metabolism in apple.

  4. Trehalose 6-phosphate signal is closely related to sorbitol in apple (Malus domestica Borkh. cv. Gala)

    Science.gov (United States)

    Zhang, Wen; Lunn, John E.; Feil, Regina; Wang, Yufei; Zhao, Jingjing; Tao, Hongxia; Zhao, Zhengyang

    2017-01-01

    ABSTRACT Trehalose-6-phosphate (Tre6P) is a precursor of trehalose, which is widespread in nature and greatly influences plant growth and development. Tre6P acts as a signal of carbon availability in many plants, but little is known about the function of Tre6P in rosaceous plants, which have specific sorbitol biosynthesis and transportation pathways. In the present study, Tre6P levels and Sorbitol:Tre6P ratios were analyzed in apple (Malus domestica, Borkh. cv. Gala). Tre6P levels were positively correlated with sorbitol content but negatively correlated with sucrose, glucose, and fructose content in developing fruit. However, under sorbitol-limited conditions, Tre6P levels were positively correlated with both sorbitol and sucrose. In the presence of different exogenous sugar supply, Tre6P levels increased corresponding with sorbitol, but this was not the case with sucrose. In addition, Tre6P content and sorbitol:Tre6P ratios were more highly correlated with ADP-glucose levels under sorbitol-limited conditions and fruit development stages, respectively. These results suggest that Tre6P is more closely related to sorbitol than other soluble sugars and has an important role in influencing carbon metabolism in apple. PMID:28069587

  5. Differential sensory cortical involvement in auditory and visual sensorimotor temporal recalibration: Evidence from transcranial direct current stimulation (tDCS).

    Science.gov (United States)

    Aytemür, Ali; Almeida, Nathalia; Lee, Kwang-Hyuk

    2017-02-01

    Adaptation to delayed sensory feedback following an action produces a subjective time compression between the action and the feedback (temporal recalibration effect, TRE). TRE is important for sensory delay compensation to maintain a relationship between causally related events. It is unclear whether TRE is a sensory modality-specific phenomenon. In 3 experiments employing a sensorimotor synchronization task, we investigated this question using cathodal transcranial direct-current stimulation (tDCS). We found that cathodal tDCS over the visual cortex, and to a lesser extent over the auditory cortex, produced decreased visual TRE. However, both auditory and visual cortex tDCS did not produce any measurable effects on auditory TRE. Our study revealed different nature of TRE in auditory and visual domains. Visual-motor TRE, which is more variable than auditory TRE, is a sensory modality-specific phenomenon, modulated by the auditory cortex. The robustness of auditory-motor TRE, unaffected by tDCS, suggests the dominance of the auditory system in temporal processing, by providing a frame of reference in the realignment of sensorimotor timing signals. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Localization and registration accuracy in image guided neurosurgery: a clinical study

    Energy Technology Data Exchange (ETDEWEB)

    Shamir, Reuben R.; Joskowicz, Leo [Hebrew University of Jerusalem, School of Engineering and Computer Science, Jerusalem (Israel); Spektor, Sergey; Shoshan, Yigal [Hadassah University Hospital, Department of Neurosurgery, School of Medicine, Jerusalem (Israel)

    2009-01-15

    To measure and compare the clinical localization and registration errors in image-guided neurosurgery, with the purpose of revising current assumptions. Twelve patients who underwent brain surgeries with a navigation system were randomly selected. A neurosurgeon localized and correlated the landmarks on preoperative MRI images and on the intraoperative physical anatomy with a tracked pointer. In the laboratory, we generated 612 scenarios in which one landmark pair was defined as the target and the remaining ones were used to compute the registration transformation. Four errors were measured: (1) fiducial localization error (FLE); (2) target registration error (TRE); (3) fiducial registration error (FRE); (4) Fitzpatrick's target registration error estimation (F-TRE). We compared the different errors and computed their correlation. The image and physical FLE ranges were 0.5-2.0 and 1.6-3.0 mm, respectively. The measured TRE, FRE and F-TRE were 4.1{+-}1.6, 3.9{+-}1.2, and 3.7{+-}2.2 mm, respectively. Low correlations of 0.19 and 0.37 were observed between the FRE and TRE and between the F-TRE and the TRE, respectively. The differences of the FRE and F-TRE from the TRE were 1.3{+-}1.0 mm (max=5.5 mm) and 1.3{+-}1.2 mm (max=7.3 mm), respectively. Contrary to common belief, the FLE presents significant variations. Moreover, both the FRE and the F-TRE are poor indicators of the TRE in image-to-patient registration. (orig.)

  7. Different functions of the insect soluble and membrane-bound trehalase genes in chitin biosynthesis revealed by RNA interference.

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    Jie Chen

    Full Text Available BACKGROUND: Trehalase, an enzyme that hydrolyzes trehalose to yield two glucose molecules, plays a pivotal role in various physiological processes. In recent years, trehalase proteins have been purified from several insect species and are divided into soluble (Tre-1 and membrane-bound (Tre-2 trehalases. However, no functions of the two trehalases in chitin biosynthesis in insects have yet been reported. PRINCIPAL FINDINGS: The membrane-bound trehalase of Spodoptera exigua (SeTre-2 was characterized in our laboratory previously. In this study, we cloned the soluble trehalase gene (SeTre-1 and investigated the tissue distribution and developmental expression pattern of the two trehalase genes. SeTre-1 was expressed highly in cuticle and Malpighian tubules, while SeTre-2 was expressed in tracheae and fat body. In the midgut, the two trehalase genes were expressed in different locations. Additionally, the expression profiles of both trehalase mRNAs and their enzyme activities suggest that they may play different roles in chitin biosynthesis. The RNA interference (RNAi of either SeTre-1 or SeTre-2 was gene-specific and effective, with efficiency rates up to 83% at 72 h post injection. After RNAi of SeTre-1 and SeTre-2, significant higher mortality rates were observed during the larva-pupa stage and pupa-adult stage, and the lethal phenotypes were classified and analyzed. Additionally, the change trends of concentration of trehalose and glucose appeared reciprocally in RNAi-mutants. Moreover, knockdown of SeTre-1 gene largely inhibited the expression of chitin synthase gene A (CHSA and reduced the chitin content in the cuticle to two-thirds relative to the control insects. The chitin synthase gene B (CHSB expression, however, was inhibited more by the injection of dsRNA for SeTre-2, and the chitin content in the midgut decreased by about 25%. CONCLUSIONS: SeTre-1 plays a major role in CHSA expression and chitin synthesis in the cuticle, and SeTre-2

  8. Réponses comportementales du brochet (Esox lucius L. à un extrait épidermique de carassin doré (Carassius auratus L. en olfactomètre

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    SAGLIO Ph.

    1993-04-01

    Full Text Available Les effets de solutions brutes (EE et d'une fraction d'acides aminés libres reconstituée (FAA, issues d'un extrait épidermique de Carassin doré (Carassius auratus L., ont été analysés sur l'attraction et le comportement exploratoire du Brochet (Esox lucius L. en olfactomètre. Des effets significatifs ont été observés en réponse aux différentes solutions et doses testées (EE = 0,005 ; 0,05 ; 0,5 équivalent-carassin/l ; FAA = 0,5 équivalent-carassin/l. L'effet stimulant des solutions épidermiques brutes sur l'exploration varie en raison inverse de la concentration testée. L'activité de ces solutions sur l'attraction augmente avec la concentration. L'effet stimulant de la fraction d'acides aminés libres reconstituée sur l'exploration et sur l'attraction est apparu inférieur à celui observé en réponse à la solution brute. Ces résultats sont discutés à la lueur de données sur le rôle des sécrétions de la peau et des acides aminés dans la communication chimique chez les poissons.

  9. Localization and registration accuracy in image guided neurosurgery: a clinical study

    International Nuclear Information System (INIS)

    Shamir, Reuben R.; Joskowicz, Leo; Spektor, Sergey; Shoshan, Yigal

    2009-01-01

    To measure and compare the clinical localization and registration errors in image-guided neurosurgery, with the purpose of revising current assumptions. Twelve patients who underwent brain surgeries with a navigation system were randomly selected. A neurosurgeon localized and correlated the landmarks on preoperative MRI images and on the intraoperative physical anatomy with a tracked pointer. In the laboratory, we generated 612 scenarios in which one landmark pair was defined as the target and the remaining ones were used to compute the registration transformation. Four errors were measured: (1) fiducial localization error (FLE); (2) target registration error (TRE); (3) fiducial registration error (FRE); (4) Fitzpatrick's target registration error estimation (F-TRE). We compared the different errors and computed their correlation. The image and physical FLE ranges were 0.5-2.0 and 1.6-3.0 mm, respectively. The measured TRE, FRE and F-TRE were 4.1±1.6, 3.9±1.2, and 3.7±2.2 mm, respectively. Low correlations of 0.19 and 0.37 were observed between the FRE and TRE and between the F-TRE and the TRE, respectively. The differences of the FRE and F-TRE from the TRE were 1.3±1.0 mm (max=5.5 mm) and 1.3±1.2 mm (max=7.3 mm), respectively. Contrary to common belief, the FLE presents significant variations. Moreover, both the FRE and the F-TRE are poor indicators of the TRE in image-to-patient registration. (orig.)

  10. Exogenous trehalose improves growth under limiting nitrogen through upregulation of nitrogen metabolism.

    Science.gov (United States)

    Lin, Yingchao; Zhang, Jie; Gao, Weichang; Chen, Yi; Li, Hongxun; Lawlor, David W; Paul, Matthew J; Pan, Wenjie

    2017-12-19

    The trehalose (Tre) pathway has strong effects on growth and development in plants through regulation of carbon metabolism. Altering either Tre or trehalose 6-phosphate (T6P) can improve growth and productivity of plants as observed under different water availability. As yet, there are no reports of the effects of modification of Tre orT6P on plant performance under limiting nutrition. Here we report that nitrogen (N) metabolism is positively affected by exogenous application of Tre in nitrogen-deficient growing conditions. Spraying foliage of tobacco (Nicotiana tabacum) with trehalose partially alleviated symptoms of nitrogen deficiency through upregulation of nitrate and ammonia assimilation and increasing activities of nitrate reductase (NR), glycolate oxidase (GO), glutamine synthetase (GS) and glutamine oxoglutarate aminotransferase (GOGAT) with concomitant changes in ammonium (NH 4 + ) and nitrate (NO 3 - ) concentrations, glutamine and amino acids. Chlorophyll and total nitrogen content of leaves and rates of photosynthesis were increased compared to nitrogen-deficient plants without applied Tre. Total plant biomass accumulation was also higher in Tre -fed nitrogen-deficient plants, with a smaller proportion of dry weight partitioned to roots, compared to nitrogen-deficient plants without applied Tre. Consistent with higher nitrogen assimilation and growth, Tre application reduced foliar starch. Minimal effects of Tre feeding were observed on nitrogen-sufficient plants. The data show, for the first time, significant stimulatory effects of exogenous Tre on nitrogen metabolism and growth in plants growing under deficient nitrogen. Under such adverse conditions metabolism is regulated for survival rather than productivity. Application of Tre can alter this regulation towards maintenance of productive functions under low nitrogen. This has implications for considering approaches to modifying the Tre pathway for to improve crop nitrogen-use efficiency and

  11. Être dans la musique Getting into the Music. Aesthetic Experience and “Mind Tripping”

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    Laurent Legrain

    2011-02-01

    Full Text Available “Être dans la musique”… cette expression maintes fois entendue dans le cadre d’interviews ou de discussions informelles menées avec des amateurs de jazz montre toute l’importance de ces moments musicaux particuliers dans les trajectoires des amateurs. Mais comment approcher analytiquement cet état fugace et, à la manière des amateurs, le placer au centre de nos préoccupations ? En dénouant le corset kantien qui enserre l’esthétique, de nombreux auteurs ont esquissé les contours d’une notion, celle de l’expérience esthétique, qui s’approche de ce que les amateurs évoquent par cette expression. Le plaisir, l’oubli de soi y sont vus comme des dimensions constitutives. Les concepts de déambulation et de logique dispositive chers au sociologue Emmanuel Belin peuvent nous aider, d’une part, à mieux cerner le dynamisme propre de cette forme d’expérience, et d’autre part, à mieux comprendre comment elle émerge d’un travail collectif sur l’environnement. Sur base de l’ethnographie d’un groupe d’amateurs se mettant en condition pour le concert du soir, cet article propose de rapprocher la notion d’expérience esthétique de celle de déambulation et de dégager la plus-value de ce rapprochement.“Getting into the music”… this expression, often heard in the context of interviews or abstract discussions held with jazz lovers, shows the major importance of these particular musical moments along the paths of jazz lovers. But how to approach this fugacious state analytically and, like jazz lovers, place it at the centre of our concerns ? In untying the Kantian corset bound around aesthetics, many authors have outlined the contours of a concept, that of aesthetic experience, approaching what jazz lovers evoke via this expression. Pleasure and forgetting oneself are seen as constitutive dimensions here. The concepts of “mind tripping” and “dispositive logic” dear to the sociologist Emmanuel

  12. Molecular cloning and expression of a novel trehalose synthase gene from Enterobacter hormaechei

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    Yue Ming

    2009-06-01

    Full Text Available Abstract Background Trehalose synthase (TreS which converts maltose to trehalose is considered to be a potential biocatalyst for trehalose production. This enzymatic process has the advantage of simple reaction and employs an inexpensive substrate. Therefore, new TreS producing bacteria with suitable enzyme properties are expected to be isolated from extreme environment. Results Six TreS producing strains were isolated from a specimen obtained from soil of the Tibetan Plateau using degenerate PCR. A novel treS gene from Enterobacter hormaechei was amplified using thermal asymmetric interlaced PCR. The gene contained a 1626 bp open reading frame encoding 541 amino acids. The gene was expressed in Escherichia coli, and the recombinant TreS was purified and characterized. The purified TreS had a molecular mass of 65 kDa and an activity of 18.5 U/mg. The optimum temperature and pH for the converting reaction were 37°C and 6, respectively. Hg2+, Zn2+, Cu2+and SDS inhibited the enzyme activity at different levels whereas Mn2+ showed an enhancing effect by 10%. Conclusion In this study, several TreS producing strains were screened from a source of soil bacteria. The characterization of the recombinant TreS of Enterobacter hormaechei suggested its potential application. Consequently, a strategy for isolation of TreS producing strains and cloning of novel treS genes from natural sources was demonstrated.

  13. [Increase of entomological indices during the pre-epidemic period of dengue in Ben Tre, South Vietnam].

    Science.gov (United States)

    Nguyen, T P Q; Luu, L L; Vu, T Q H; Buisson, Y

    2011-10-01

    Dengue has emerged in Vietnam 50 years ago and since has become endemo-epidemic throughout the whole country. Each year, major epidemics of dengue fever (DF) and dengue hemorrhagic fever (DHF) hit South Vietnam during the rainy season, causing significant morbidity and mortality, especially among young children. The only preventive measure is vector control, but it is often implemented too late or indiscriminately. The aim of this study was to investigate, in the pre-epidemic stage, the existence of significant changes in vector indices, which will predict DF/DHF outbreaks. We conducted a descriptive transversal study, repeated once a month for four months (March to June) in the village of Locthuan (province Ben Tre) in the Mekong's delta. Adult mosquitoes were caught in 30 houses, and larvae were collected in water holding containers of 50 houses. The houses were randomly selected. Vector densities were calculated according to the indices recommended by WHO. Virological analysis was carried out on lots of female Aedes and larvae in order to determine viral infection rates. Catches of adult mosquitoes collected 496 specimens including 329 Aedes, 139 Culex and 28 Anopheles. Aedes aegypti was present in 63% of visited homes that is an average density of 1.8 mosquitoes per house. The increase in imaginal indices during the 4 months was not significant. The survey of breeding sites of Ae. aegypti identified 1292 water containers in which 71,569 larval specimens were collected. The values of house index, container index [CI] and Breteau index [BI] increased each month, the latter from 166 to 442. This increase was significant for CI and BI. Breeding sites were mostly intra-home, mainly consisting of large and small ceramic jars. Larval density of Ae. aegypti in the containers also increased significantly over the 4 months. It was correlated with the lack of cover and predators such as Mesocyclops spp., Micronecta spp. and larvivorous fishes. Cultivation of 15 pools of

  14. Exogenous Trehalose Largely Alleviates Ionic Unbalance, ROS Burst and PCD Occurrence Induced by High Salinity in Arabidopsis Seedlings

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    Lei eYang

    2014-10-01

    Full Text Available Trehalose (Tre has been reported to play a critical role in plant response to salinity and the involved mechanisms remain to be investigated in detail. Here, the putative roles of Tre in regulation of ionic balance, cellular redox state, cell death were studied in Arabidopsis under high salt condition. Our results found that the salt-induced restrictions on both vegetative and reproductive growth in salt-stressed plants were largely alleviated by exogenous supply with Tre. The microprobe analysis of ionic dynamics in the leaf and stem of florescence highlighted the Tre ability to retain K and K/Na ratio in plant tissues to improve salt tolerance. The flow cytometric (FCM assay of cellular levels of ROS (reactive oxygen species and PCD (programmed cell death displayed that Tre was able to antagonized salt-induced damages in redox state and cell death and sucrose did not play the same role with Tre. By comparing ionic distribution in leaf and IS (inflorescence stem, we found that Tre was able to restrict Na transportation to IS from leaves since that the ratio of Na accumulation in leaves relative to IS was largely improved due to Tre. The marked decrease of Na ion and improved sucrose level in IS might account for the promoted floral growth when Tre was included in the saline solution. At the same time, endogenous soluble sugars and antioxidant enzyme activities in the salt-stressed plants were also elevated by Tre to counteract high salt stress. We concluded that Tre could improve Arabidopsis salt resistance with respect to biomass accumulation and floral transition in the means of regulating plant redox state, cell death and ionic distribution.

  15. Development of automatic navigation measuring system using template-matching software in image guided neurosurgery

    International Nuclear Information System (INIS)

    Watanabe, Yohei; Hayashi, Yuichiro; Fujii, Masazumi; Wakabayashi, Toshihiko; Kimura, Miyuki; Tsuzaka, Masatoshi; Sugiura, Akihiro

    2010-01-01

    An image-guided neurosurgery and neuronavigation system based on magnetic resonance imaging has been used as an indispensable tool for resection of brain tumors. Therefore, accuracy of the neuronavigation system, provided by periodic quality assurance (QA), is essential for image-guided neurosurgery. Two types of accuracy index, fiducial registration error (FRE) and target registration error (TRE), have been used to evaluate navigation accuracy. FRE shows navigation accuracy on points that have been registered. On the other hand, TRE shows navigation accuracy on points such as tumor, skin, and fiducial markers. This study shows that TRE is more reliable than FRE. However, calculation of TRE is a time-consuming, subjective task. Software for QA was developed to compute TRE. This software calculates TRE automatically by an image processing technique, such as automatic template matching. TRE was calculated by the software and compared with the results obtained by manual calculation. Using the software made it possible to achieve a reliable QA system. (author)

  16. Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin.

    Science.gov (United States)

    Ridolfi, Daniela M; Marcato, Priscyla D; Justo, Giselle Z; Cordi, Lívia; Machado, Daisy; Durán, Nelson

    2012-05-01

    Tretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. The hydrodynamic mean diameter and zeta potential were 162.7±1.4 nm and -31.9±2.0 mV for SLN-TRE, and 284.8±15.0 nm and 55.9±3.1 mV for SLN-chitosan-TRE. The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acne. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Effects of dietary supplementation with turmeric rhizome extract on growth performance, carcass characteristics, antioxidant capability, and meat quality of Wenchang broiler chickens

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    Dingfa Wang

    2015-07-01

    Full Text Available Our study aimed to determine the effect of increasing dietary levels of turmeric rhizome extract (TRE on performance, carcass characteristics, antioxidant capability and meat quality of Wenchang broiler chickens. Three hundred, 1-day-old Wenchang broiler chickens were brooded together for 2 weeks, then randomly allocated into four treatments with five replicates of 15 birds each. Birds were fed a corn-soybean basal diet supplemented with TRE at 0, 100, 200 and 300 mg/kg for 12 weeks. The results revealed that a TRE-supplemented diet had no significant effect (P>0.05 on the body weight, although birds fed a diet with TRE at 100 and 200 mg/kg had higher average daily weight gains and average daily feed as compared to controls from 9 to 12 week (P<0.05. Also, the addition of TRE at 100 to 300 mg/kg had a better feed conversion ratio compared to controls from week 9 to 12 (P<0.05. Dietary supplementation with TRE at 300 mg/kg increased the breast muscle weight ratio (P<0.05. Meanwhile, dietary supplementation with TRE at 100 to 300 mg/kg reduced the abdominal fat ratio (P<0.05, compared to that of the control group. TRE increased enzymatic activities of superoxide dismutase and glutathione peroxidase, and reduced malondiadehhyde concentrations, compared to the control group. Dietary TRE supplementation at 300 mg/kg decreased the drip loss in both breast muscle and thigh muscles, compared with the control group (P<0.05. In conclusion, dietary TRE supplementation enhanced antioxidant capability, growth performance, breast muscle weight ratio, and reduced the abdominal fat ratio of Wenchang broiler chickens.

  18. Christophe Couderc, Le théâtre tragique au Siècle d’or. Cristóbal de Virués, Lope de Vega, Calderón de la Barca - Christophe Couderc and Hélène Tropé, eds., La tragédie espagnole et son contexte européen. xvie-xviie siècles

    Directory of Open Access Journals (Sweden)

    Luigi Giuliani

    2015-01-01

    Full Text Available Review of Christophe Couderc, Le théâtre tragique au Siècle d’or. Cristóbal de Virués, Lope de Vega, Calderón de la Barca, CNED, Paris, 2012, 170 pp. ISBN: 978213060871 and Christophe Couderc and Hélène Tropé, eds., La tragédie espagnole et son contexte européen. xvie-xviie siècles, Presses Sorbonne Nouvelle, Paris, 2013, 266 pp. ISBN: 9782878546118.

  19. Flux through trehalose synthase flows from trehalose to the alpha anomer of maltose in mycobacteria.

    Science.gov (United States)

    Miah, Farzana; Koliwer-Brandl, Hendrik; Rejzek, Martin; Field, Robert A; Kalscheuer, Rainer; Bornemann, Stephen

    2013-04-18

    Trehalose synthase (TreS) was thought to catalyze flux from maltose to trehalose, a precursor of essential trehalose mycolates in mycobacterial cell walls. However, we now show, using a genetic approach, that TreS is not required for trehalose biosynthesis in Mycobacterium smegmatis, whereas two alternative trehalose-biosynthetic pathways (OtsAB and TreYZ) are crucial. Consistent with this direction of flux, trehalose levels in Mycobacterium tuberculosis decreased when TreS was overexpressed. In addition, TreS was shown to interconvert the α anomer of maltose and trehalose using (1)H and (19)F-nuclear magnetic resonance spectroscopies using its normal substrates and deoxyfluoromaltose analogs, with the nonenzymatic mutarotation of α/β-maltose being slow. Therefore, flux through TreS in mycobacteria flows from trehalose to α-maltose, which is the appropriate anomer for maltose kinase of the GlgE α-glucan pathway, which in turn contributes to intracellular and/or capsular polysaccharide biosynthesis. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Indeklimamærkning af byggevarer

    DEFF Research Database (Denmark)

    Wolkoff, P.; Nielsen, P.A.

    Denne rapport beskriver laboratorieforsøg med ni byggevarer - tre fugemasser, tre malinger og tre tekstile gulvbelægninger - samt modelberegninger og sundhedsmæssige vurderinger. Resultaterne heraf udgør det faglige og tekniske grundlag for indeklimamærkningsordningen. Formålet har været at under...

  1. En tragisk parodi

    DEFF Research Database (Denmark)

    Etemadi, Maziar Haghpaidar

    2004-01-01

    Tre skikkelser symboliserer den europæiske ånds gang gennem historien; disse tre er antikkens homeriske helt Odysseus; Dantes opdigtede selvbiografi i den førmoderne og kristne middelalderlige fortælling Den guddommelige komedie og endelig Goethes moderne historie om Faust.......Tre skikkelser symboliserer den europæiske ånds gang gennem historien; disse tre er antikkens homeriske helt Odysseus; Dantes opdigtede selvbiografi i den førmoderne og kristne middelalderlige fortælling Den guddommelige komedie og endelig Goethes moderne historie om Faust....

  2. Il est beau le lavabo, il est laid le bidet

    DEFF Research Database (Denmark)

    Nølke, Henning

    1998-01-01

    Artiklen analyserer dislokering af subjektet på fransk. Der skelnes mellem tre hovedtyper: venstredislokering med og uden intonationsbrud og højre dislokering. I alle tilfælde indeholder sætningskernen principielt en pronominel kopi af subjektet. Det påvises, at de tre typer svarer til tre forske...

  3. Modulation of inflammation and autophagy pathways by trehalose containing eye drop formulation in corneal epithelial cells: implications for dry eye disease

    Directory of Open Access Journals (Sweden)

    Trailokyanath Panigrahi

    2017-10-01

    Full Text Available Ocular surface inflammation is an immunological perturbation activated in response to various adverse conditions and is a key biomarker to understand the disease pathology and its underlying immunological landscape [1]. The molecular link between Inflammation and autophagy, often implicated in disease conditions, is poorly understood. The aim of this study is to understand the regulation of inflammation signaling pathways by using a well-established modulator of autophagy, trehalose (TRE, on desiccation stress-induced inflammation in SV40 immortalized human corneal epithelial cells. To mimic the dry eye condition, HCE cells were exposed to desiccation stress at 80% confluency in a six well tissue culture plate. The medium was completely aspirated and cells were kept for drying at room temperature for 10 min. Fresh medium with TRE was added and incubated for 6 hrs. The regulation of induced inflammatory and autophagic gene expression and protein activation by TRE formulation (1.2% was studied. Optimal drug treatment concentrations were determined by dose escalation cytotoxicity studies. Gene expression was evaluated by quantitative PCR, while protein expression and functions were tested by immunoblotting and fluorescence imaging (Cyto-ID, Lysotracker Red. TRE formulation was able to rescue the morphological changes due to desiccation stress. Live to dead cell ratio increased upon TRE treatment. TRE treatment reduced inflammation induced gene expression of IL-6 (2%, MCP-1 (33.31%, IL-8 (9.56%, MMP-9 (18.96%, and TNFα (58.16% in HCE. Active form of p38, p44/42, and p65 protein levels were altered significantly by TRE treatment. LAMP1 and LC3 autophagy protein markers were also altered with desiccation stress and TRE treatment. The data demonstrate that TRE formulation is effective in reducing desiccation stress induced inflammation in HCE. Further increased phosphorylation of p38, p44/42 and elevated levels of LC3 and LAMP1 suggest that induction

  4. Hand-eye calibration using a target registration error model.

    Science.gov (United States)

    Chen, Elvis C S; Morgan, Isabella; Jayarathne, Uditha; Ma, Burton; Peters, Terry M

    2017-10-01

    Surgical cameras are prevalent in modern operating theatres and are often used as a surrogate for direct vision. Visualisation techniques (e.g. image fusion) made possible by tracking the camera require accurate hand-eye calibration between the camera and the tracking system. The authors introduce the concept of 'guided hand-eye calibration', where calibration measurements are facilitated by a target registration error (TRE) model. They formulate hand-eye calibration as a registration problem between homologous point-line pairs. For each measurement, the position of a monochromatic ball-tip stylus (a point) and its projection onto the image (a line) is recorded, and the TRE of the resulting calibration is predicted using a TRE model. The TRE model is then used to guide the placement of the calibration tool, so that the subsequent measurement minimises the predicted TRE. Assessing TRE after each measurement produces accurate calibration using a minimal number of measurements. As a proof of principle, they evaluated guided calibration using a webcam and an endoscopic camera. Their endoscopic camera results suggest that millimetre TRE is achievable when at least 15 measurements are acquired with the tracker sensor ∼80 cm away on the laparoscope handle for a target ∼20 cm away from the camera.

  5. Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

    Science.gov (United States)

    Djonović, Slavica; Urbach, Jonathan M; Drenkard, Eliana; Bush, Jenifer; Feinbaum, Rhonda; Ausubel, Jonathan L; Traficante, David; Risech, Martina; Kocks, Christine; Fischbach, Michael A; Priebe, Gregory P; Ausubel, Frederick M

    2013-03-01

    Pseudomonas aeruginosa strain PA14 is a multi-host pathogen that infects plants, nematodes, insects, and vertebrates. Many PA14 factors are required for virulence in more than one of these hosts. Noting that plants have a fundamentally different cellular architecture from animals, we sought to identify PA14 factors that are specifically required for plant pathogenesis. We show that synthesis by PA14 of the disaccharide trehalose is required for pathogenesis in Arabidopsis, but not in nematodes, insects, or mice. In-frame deletion of two closely-linked predicted trehalose biosynthetic operons, treYZ and treS, decreased growth in Arabidopsis leaves about 50 fold. Exogenously co-inoculated trehalose, ammonium, or nitrate, but not glucose, sulfate, or phosphate suppressed the phenotype of the double ΔtreYZΔtreS mutant. Exogenous trehalose or ammonium nitrate does not suppress the growth defect of the double ΔtreYZΔtreS mutant by suppressing the plant defense response. Trehalose also does not function intracellularly in P. aeruginosa to ameliorate a variety of stresses, but most likely functions extracellularly, because wild-type PA14 rescued the in vivo growth defect of the ΔtreYZΔtreS in trans. Surprisingly, the growth defect of the double ΔtreYZΔtreS double mutant was suppressed by various Arabidopsis cell wall mutants that affect xyloglucan synthesis, including an xxt1xxt2 double mutant that completely lacks xyloglucan, even though xyloglucan mutants are not more susceptible to pathogens and respond like wild-type plants to immune elicitors. An explanation of our data is that trehalose functions to promote the acquisition of nitrogen-containing nutrients in a process that involves the xyloglucan component of the plant cell wall, thereby allowing P. aeruginosa to replicate in the intercellular spaces in a leaf. This work shows how P. aeruginosa, a multi-host opportunistic pathogen, has repurposed a highly conserved "house-keeping" anabolic pathway (trehalose

  6. Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

    Directory of Open Access Journals (Sweden)

    Slavica Djonović

    2013-03-01

    Full Text Available Pseudomonas aeruginosa strain PA14 is a multi-host pathogen that infects plants, nematodes, insects, and vertebrates. Many PA14 factors are required for virulence in more than one of these hosts. Noting that plants have a fundamentally different cellular architecture from animals, we sought to identify PA14 factors that are specifically required for plant pathogenesis. We show that synthesis by PA14 of the disaccharide trehalose is required for pathogenesis in Arabidopsis, but not in nematodes, insects, or mice. In-frame deletion of two closely-linked predicted trehalose biosynthetic operons, treYZ and treS, decreased growth in Arabidopsis leaves about 50 fold. Exogenously co-inoculated trehalose, ammonium, or nitrate, but not glucose, sulfate, or phosphate suppressed the phenotype of the double ΔtreYZΔtreS mutant. Exogenous trehalose or ammonium nitrate does not suppress the growth defect of the double ΔtreYZΔtreS mutant by suppressing the plant defense response. Trehalose also does not function intracellularly in P. aeruginosa to ameliorate a variety of stresses, but most likely functions extracellularly, because wild-type PA14 rescued the in vivo growth defect of the ΔtreYZΔtreS in trans. Surprisingly, the growth defect of the double ΔtreYZΔtreS double mutant was suppressed by various Arabidopsis cell wall mutants that affect xyloglucan synthesis, including an xxt1xxt2 double mutant that completely lacks xyloglucan, even though xyloglucan mutants are not more susceptible to pathogens and respond like wild-type plants to immune elicitors. An explanation of our data is that trehalose functions to promote the acquisition of nitrogen-containing nutrients in a process that involves the xyloglucan component of the plant cell wall, thereby allowing P. aeruginosa to replicate in the intercellular spaces in a leaf. This work shows how P. aeruginosa, a multi-host opportunistic pathogen, has repurposed a highly conserved "house-keeping" anabolic

  7. La première traduction slave de Molière et la naissance du théâtre slovène

    Directory of Open Access Journals (Sweden)

    Boštjan Marko Turk

    2008-12-01

    Full Text Available Trois ans après sa première représentation à Versailles, Georges Dandin de Molière a fait l 'objet d'une traduction partielle en slovène réalisée par Franjo Krsto Frankopan. Cette traduction des trois premières scènes peut être objectivement considérée comme l'un des défis les plus ardus de l'histoire littéraire contemporaine. La recherche slovène et internationale l'a tantôt ignoré, tantôt considéré comme lettre morte. La raison en est que, dans ce fragment, Frankopan aurait utilisé le slovène comme langue servant à ridiculiser, comme l'ayaient fait les dramaturges italiens de la Renaissance avec les dialectes slaves. Or, rien n'est plus éloigné de la vérité. Le texte est intégralement écrit en slovène, langue de la mère de Frankopan. Du reste, comme le montre ne serait-ce que l'analyse bergsonienne du comique, Georges Dandin n'est pas un texte comique. Il convient, par contre, de voir le lien entre la traduction du fragment de la pièce de Molière et l'action de Frankopan contre la monarchie habsbourgeoise. Par l'intermédiaire de la diplomatie viennoise, ce dernier cherchait en effet des appuis à la cour du .roi Louis XIV dont l'auteur dramatique comique en titre était précisément Molière. En conclusion, il convient de souligner que le fragment traduit par Frankopan, en tant que premier texte dramatique en langue slovène, invite à remettre en question la datation des débuts du théâtre slovène proposée par les historiens de la littérature.

  8. Politik som fiktion

    DEFF Research Database (Denmark)

    Aagaard, Peter

    2017-01-01

    Hvor politisk kommunikation tidligere var domineret af tre M’er – Marketing, Meningsmåling og Massemedier - så er vi i dag trådt ind i en ny epoke domineret af tre F’er: Følelser, Fiktioner og Facebook. Med udgangspunkt i et casestudie af Trumps kampagne i 2016. og de tre begreber - politisk...

  9. First echinoderm trehalase from a tropical sea cucumber (Holothuria leucospilota): Molecular cloning and mRNA expression in different tissues, embryonic and larval stages, and under a starvation challenge.

    Science.gov (United States)

    Huo, Da; Jiang, Xiao; Wu, Xiaofen; Ren, Chunhua; Yu, Zonghe; Liu, Jinshang; Li, Hongmei; Ruan, Yao; Wen, Jin; Chen, Ting; Hu, Chaoqun

    2018-04-29

    Trehalases are a group of enzymes that catalyse the conversion of trehalose to glucose, and they are observed in most organisms. In this study, the first echinoderm trehalase, designated Hl-Tre, was identified from a tropical sea cucumber, Holothuria leucospilota. The full-length cDNA of H. leucospilota trehalase (Hl-Tre) is 2461 bp in length with an open reading frame (ORF) of 1788 bp that encodes a 595-amino-acid protein with a deduced molecular weight of 67.95 KDa. The Hl-Tre protein contains a signal peptide at the N-terminal and a functional trehalase domain, which includes the signature motifs 1 and 2. The mRNA expression of Hl-Tre was ubiquitously detected in all selected tissues, with the highest level being detected in the intestine. By in situ hybridization (ISH), the positive Hl-Tre signals were observed in the brush borders of the intestinal mucosa. In embryonic and larval stages, the transcript levels of Hl-Tre decreased during embryonic development and increased after the pentactula stage. After a challenge of starvation, the intestinal Hl-Tre mRNA levels were observed to be first decreased and partially recovered thereafter. Overall, our study provided the first evidence for trehalase in echinoderms and showed that this enzyme was potentially linked to a trehalose metabolic pathway in sea cucumbers. Copyright © 2017. Published by Elsevier B.V.

  10. Tre uger 'over there'

    DEFF Research Database (Denmark)

    Brandt, Eva; Binder, Thomas

    2007-01-01

    Vi ser ofte mod USA når der skal findes inspiration for udviklingen af det hjemlige. IDEO er en af de mest interessante design konsulentvirksomheder, og Institute of Design på IIT i Chicago (ID) er den første amerikanske uddannelsesinstitution, der har påbegyndt forskeruddannelsen i design. Vi tog...

  11. 40 CFR 63.118 - Process vent provisions-periodic reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... device or other means to achieve and maintain a TRE index value greater than 1.0 but less than 4.0 as... subpart and who elects to demonstrate compliance with the TRE index value greater than 4.0 under § 63.113... § 63.115(e) of this subpart, is made that causes a Group 2 process vent with a TRE greater than 4.0 to...

  12. An update to the HIV-TRePS system: the development of new computational models that do not require a genotype to predict HIV treatment outcomes.

    Science.gov (United States)

    Revell, Andrew D; Wang, Dechao; Wood, Robin; Morrow, Carl; Tempelman, Hugo; Hamers, Raph; Alvarez-Uria, Gerardo; Streinu-Cercel, Adrian; Ene, Luminita; Wensing, Annemarie; Reiss, Peter; van Sighem, Ard I; Nelson, Mark; Emery, Sean; Montaner, Julio S G; Lane, H Clifford; Larder, Brendan A

    2014-04-01

    The optimal individualized selection of antiretroviral drugs in resource-limited settings is challenging because of the limited availability of drugs and genotyping. Here we describe the development of the latest computational models to predict the response to combination antiretroviral therapy without a genotype, for potential use in such settings. Random forest models were trained to predict the probability of a virological response to therapy (HIV RNA/mL) following virological failure using the following data from 22,567 treatment-change episodes including 1090 from southern Africa: baseline viral load and CD4 cell count, treatment history, drugs in the new regimen, time to follow-up and follow-up viral load. The models were assessed during cross-validation and with an independent global test set of 1000 cases including 100 from southern Africa. The models' accuracy [area under the receiver-operating characteristic curve (AUC)] was evaluated and compared with genotyping using rules-based interpretation systems for those cases with genotypes available. The models achieved AUCs of 0.79-0.84 (mean 0.82) during cross-validation, 0.80 with the global test set and 0.78 with the southern African subset. The AUCs were significantly lower (0.56-0.57) for genotyping. The models predicted virological response to HIV therapy without a genotype as accurately as previous models that included a genotype. They were accurate for cases from southern Africa and significantly more accurate than genotyping. These models will be accessible via the online treatment support tool HIV-TRePS and have the potential to help optimize antiretroviral therapy in resource-limited settings where genotyping is not generally available.

  13. La recherche sur la sécurité alimentaire améliore les conditions de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 mai 2016 ... ... accroître l'accès à la terre et aux ressources pour assurer l'autonomisation des femmes et lutter contre les inégalités entre les sexes; faire connaître les technologies aquacoles et postrécoltes qui permettent aux agriculteurs d'accéder aux marchés; accroître la production et la consommation de petits mils ...

  14. Active site characterization and molecular cloning of Tenebrio molitor midgut trehalase and comments on their insect homologs.

    Science.gov (United States)

    Gomez, Ana; Cardoso, Christiane; Genta, Fernando A; Terra, Walter R; Ferreira, Clélia

    2013-08-01

    The soluble midgut trehalase from Tenebrio molitor (TmTre1) was purified after several chromatographic steps, resulting in an enzyme with 58 kDa and pH optimum 5.3 (ionizing active groups in the free enzyme: pK(e1) = 3.8 ± 0.2 pK(e2) = 7.4 ± 0.2). The purified enzyme corresponds to the deduced amino acid sequence of a cloned cDNA (TmTre1-cDNA), because a single cDNA coding a soluble trehalase was found in the T. molitor midgut transcriptome. Furthermore, the mass of the protein predicted to be coded by TmTre1-cDNA agrees with that of the purified enzyme. TmTre1 has the essential catalytic groups Asp 315 and Glu 513 and the essential Arg residues R164, R217, R282. Carbodiimide inactivation of the purified enzyme at different pH values reveals an essential carboxyl group with pKa = 3.5 ± 0.3. Phenylglyoxal modified a single Arg residue with pKa = 7.5 ± 0.2, as observed in the soluble trehalase from Spodoptera frugiperda (SfTre1). Diethylpyrocarbonate modified a His residue that resulted in a less active enzyme with pK(e1) changed to 4.8 ± 0.2. In TmTre1 the modified His residue (putatively His 336) is more exposed than the His modified in SfTre1 (putatively His 210) and that affects the ionization of an Arg residue. The architecture of the active site of TmTre1 and SfTre1 is different, as shown by multiple inhibition analysis, the meaning of which demands further research. Trehalase sequences obtained from midgut transcriptomes (pyrosequencing and Illumina data) from 8 insects pertaining to 5 different orders were used in a cladogram, together with other representative sequences. The data suggest that the trehalase gene went duplication and divergence prior to the separation of the paraneopteran and holometabolan orders and that the soluble trehalase derived from the membrane-bound one by losing the C-terminal transmembrane loop. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Raccontare la storia al tempo delle crisi

    OpenAIRE

    La Valle, Paolo

    2015-01-01

    La ricerca analizza il tema della relazione tra storia e narrazione nella letteratura degli ultimi quindici anni in tre contesti nazionali: Italia, Spagna e Portogalo. Per indagare un campo così vasto si sono identificate tre direttrici principali connesse tra loro, coincidenti con tre "crisi": la crisi del rapporto tra letteratura e mercato, la crisi del concetto di verità e la crisi dello stato nazione. Attraverso le riflessioni sul postmoderno (Lyotard, Jameson Hutcheon) e l’analisi di...

  16. Offers

    CERN Multimedia

    Staff association

    2014-01-01

        Envie de soirée au théâtre, n’hésitez pas à bénéficier de nos offres pour nos membres ! Théâtre de Carouge : Réduction de 5 CHF pour tous les spectacles (30 CHF au lieu de 35 CHF) Le théâtre de Carouge vous présente sa nouvelle pièce : La double insconstance Du vedredi 21 mars au dimanche 6 avril 2014 De Marivaux Mise en scène de Philippe Mentha Audio-description le mardi 1er avril et le samedi 5 avril 2014 Il règne un doux mélange de révoltes et de séductions, de ruses et de fatalité dans cette Double Inconstance de Marivaux que met en scène Philippe Mentha, membre fondateur du Théâtre de Carouge et directeur depuis plus de trente ans du Théâtre Kléber-Méleau. L’allure d...

  17. Feedback Inhibition of Starch Degradation in Arabidopsis Leaves Mediated by Trehalose 6-Phosphate1[W][OPEN

    Science.gov (United States)

    Martins, Marina Camara Mattos; Hejazi, Mahdi; Fettke, Joerg; Steup, Martin; Feil, Regina; Krause, Ursula; Arrivault, Stéphanie; Vosloh, Daniel; Figueroa, Carlos María; Ivakov, Alexander; Yadav, Umesh Prasad; Piques, Maria; Metzner, Daniela; Stitt, Mark; Lunn, John Edward

    2013-01-01

    Many plants accumulate substantial starch reserves in their leaves during the day and remobilize them at night to provide carbon and energy for maintenance and growth. In this paper, we explore the role of a sugar-signaling metabolite, trehalose-6-phosphate (Tre6P), in regulating the accumulation and turnover of transitory starch in Arabidopsis (Arabidopsis thaliana) leaves. Ethanol-induced overexpression of trehalose-phosphate synthase during the day increased Tre6P levels up to 11-fold. There was a transient increase in the rate of starch accumulation in the middle of the day, but this was not linked to reductive activation of ADP-glucose pyrophosphorylase. A 2- to 3-fold increase in Tre6P during the night led to significant inhibition of starch degradation. Maltose and maltotriose did not accumulate, suggesting that Tre6P affects an early step in the pathway of starch degradation in the chloroplasts. Starch granules isolated from induced plants had a higher orthophosphate content than granules from noninduced control plants, consistent either with disruption of the phosphorylation-dephosphorylation cycle that is essential for efficient starch breakdown or with inhibition of starch hydrolysis by β-amylase. Nonaqueous fractionation of leaves showed that Tre6P is predominantly located in the cytosol, with estimated in vivo Tre6P concentrations of 4 to 7 µm in the cytosol, 0.2 to 0.5 µm in the chloroplasts, and 0.05 µm in the vacuole. It is proposed that Tre6P is a component in a signaling pathway that mediates the feedback regulation of starch breakdown by sucrose, potentially linking starch turnover to demand for sucrose by growing sink organs at night. PMID:24043444

  18. Cura Annonae-Chemically Boosting Crop Yields Through Metabolic Feeding of a Plant Signaling Precursor.

    Science.gov (United States)

    Vocadlo, David J

    2017-05-22

    The cream of the crop: With the world facing a projected shortfall of crops by 2050, new approaches are needed to boost crop yields. Metabolic feeding of plants with photocaged trehalose-6-phosphate (Tre6P) can increase levels of the signaling metabolite Tre6P in the plant. Reprogramming of cellular metabolism by Tre6P stimulates a program of plant growth and enhanced crop yields, while boosting starch content. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. TU-AB-202-06: Quantitative Evaluation of Deformable Image Registration in MRI-Guided Adaptive Radiation Therapy

    International Nuclear Information System (INIS)

    Mooney, K; Zhao, T; Green, O; Mutic, S; Yang, D; Duan, Y; Zhang, M

    2016-01-01

    Purpose: To assess the performance of the deformable image registration algorithm used for MRI-guided adaptive radiation therapy using image feature analysis. Methods: MR images were collected from five patients treated on the MRIdian (ViewRay, Inc., Oakwood Village, OH), a three head Cobalt-60 therapy machine with an 0.35 T MR system. The images were acquired immediately prior to treatment with a uniform 1.5 mm resolution. Treatment sites were as follows: head/neck, lung, breast, stomach, and bladder. Deformable image registration was performed using the ViewRay software between the first fraction MRI and the final fraction MRI, and the DICE similarity coefficient (DSC) for the skin contours was reported. The SIFT and Harris feature detection and matching algorithms identified point features in each image separately, then found matching features in the other image. The target registration error (TRE) was defined as the vector distance between matched features on the two image sets. Each deformation was evaluated based on comparison of average TRE and DSC. Results: Image feature analysis produced between 2000–9500 points for evaluation on the patient images. The average (± standard deviation) TRE for all patients was 3.3 mm (±3.1 mm), and the passing rate of TRE<3 mm was 60% on the images. The head/neck patient had the best average TRE (1.9 mm±2.3 mm) and the best passing rate (80%). The lung patient had the worst average TRE (4.8 mm±3.3 mm) and the worst passing rate (37.2%). DSC was not significantly correlated with either TRE (p=0.63) or passing rate (p=0.55). Conclusions: Feature matching provides a quantitative assessment of deformable image registration, with a large number of data points for analysis. The TRE of matched features can be used to evaluate the registration of many objects throughout the volume, whereas DSC mainly provides a measure of gross overlap. We have a research agreement with ViewRay Inc.

  20. TU-AB-202-06: Quantitative Evaluation of Deformable Image Registration in MRI-Guided Adaptive Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Mooney, K; Zhao, T; Green, O; Mutic, S; Yang, D [Washington University School of Medicine, Saint Louis, MO (United States); Duan, Y [University of Missouri, Columbia, Missouri (United States); Zhang, M [Oregon Health and Science University, Portland, Oregon (United States)

    2016-06-15

    Purpose: To assess the performance of the deformable image registration algorithm used for MRI-guided adaptive radiation therapy using image feature analysis. Methods: MR images were collected from five patients treated on the MRIdian (ViewRay, Inc., Oakwood Village, OH), a three head Cobalt-60 therapy machine with an 0.35 T MR system. The images were acquired immediately prior to treatment with a uniform 1.5 mm resolution. Treatment sites were as follows: head/neck, lung, breast, stomach, and bladder. Deformable image registration was performed using the ViewRay software between the first fraction MRI and the final fraction MRI, and the DICE similarity coefficient (DSC) for the skin contours was reported. The SIFT and Harris feature detection and matching algorithms identified point features in each image separately, then found matching features in the other image. The target registration error (TRE) was defined as the vector distance between matched features on the two image sets. Each deformation was evaluated based on comparison of average TRE and DSC. Results: Image feature analysis produced between 2000–9500 points for evaluation on the patient images. The average (± standard deviation) TRE for all patients was 3.3 mm (±3.1 mm), and the passing rate of TRE<3 mm was 60% on the images. The head/neck patient had the best average TRE (1.9 mm±2.3 mm) and the best passing rate (80%). The lung patient had the worst average TRE (4.8 mm±3.3 mm) and the worst passing rate (37.2%). DSC was not significantly correlated with either TRE (p=0.63) or passing rate (p=0.55). Conclusions: Feature matching provides a quantitative assessment of deformable image registration, with a large number of data points for analysis. The TRE of matched features can be used to evaluate the registration of many objects throughout the volume, whereas DSC mainly provides a measure of gross overlap. We have a research agreement with ViewRay Inc.

  1. Isolation and identification of a thermophilic strain producing trehalose synthase from geothermal water in China.

    Science.gov (United States)

    Zhu, Yueming; Zhang, Jun; Wei, Dongsheng; Wang, Yufan; Chen, Xiaoyun; Xing, Laijun; Li, Mingchun

    2008-08-01

    A slightly thermophilic strain, CBS-01, producing trehalose synthase (TreS), was isolated from geothermal water in this study. According to the phenotypic characteristics and phylogenetic analysis of the 16s rRNA gene sequence, it was identified as Meiothermus ruber. The trehalose synthase gene of Meiothermus ruber CBS-01 was cloned by polymerase chain reaction and sequenced. The TreS gene consisted of 2,895 nucleotides, which specified a 964-amino-acid protein. This novel TreS catalyzed reversible interconversion of maltose and trehalose.

  2. 54 grønlandske slædehunde kom under lup

    DEFF Research Database (Denmark)

    Kortegaard, Hanne Ellen; Nielsen, Dorte Hald

    2009-01-01

    Tre dyrlæger, tre veterinærstuderende og en veterinærsygeplejerske fra Institut for Mindre Husdyrs Sygdomme på KU LIFE kom på oplevelsesrigt og udfordrende klinisk projekt på et af Danmarks yderpunkter...

  3. Undersøgelsen af brugernes evaluering af kontorpakker på Århus Sygehus og i Psykiatrien i Århus

    DEFF Research Database (Denmark)

    Hørlück, Jens

    En analyse af brugernes opfattelse af kvaliteten af tre office pakker: MS Office 2003 / 2007 og OpenOffice.  ......En analyse af brugernes opfattelse af kvaliteten af tre office pakker: MS Office 2003 / 2007 og OpenOffice.  ...

  4. Dramatik, dialog, duel

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2006-01-01

    Introduktion til instrumentalkoncerten som genre i Bent Lorentzens oeuvre, og beskrivelse af tre koncerter: Klaverkoncerten, Italiensk koncert og Jagtkoncert......Introduktion til instrumentalkoncerten som genre i Bent Lorentzens oeuvre, og beskrivelse af tre koncerter: Klaverkoncerten, Italiensk koncert og Jagtkoncert...

  5. Stiilsed emad ja tütred / Keilit Aedma

    Index Scriptorium Estoniae

    Aedma, Keilit

    2016-01-01

    Sisearhitekt Aet Pieli ja tema tütre Anrike Pieli, moedisainer Roberta Eineri ja tema ema Ljudmilla Eineri, tekstiilikunstnik Signe Kivi ja tema tütre Liisa Kivi, ajakirjanik Keilit Aedma ja tema ema Kadi Aedma-Reiningu riietumisstiilist

  6. Musik, Sprog og Integration

    DEFF Research Database (Denmark)

    Holst, Finn

    2010-01-01

    Evaluering af projektet Musik, Sprog og Integration, Søndermarkskolen, Horsens. Andenårsevaluering af et treårigt projekt.......Evaluering af projektet Musik, Sprog og Integration, Søndermarkskolen, Horsens. Andenårsevaluering af et treårigt projekt....

  7. Hepatic stellate cells lack AP-1 responsiveness to electrophiles and phorbol 12-myristate-13-acetate

    International Nuclear Information System (INIS)

    Reichard, John F.; Petersen, Dennis R.

    2004-01-01

    Stellate cell profibrotic gene induction and transdifferentiation are central events in liver fibrosis. Oxidative stress has been implicated as an activator of the transcription factors Nrf2 and AP-1 through shared kinase signaling pathways that also purportedly contribute to stellate cell activation. The present study examined the role of oxidative stress in ARE- and TRE-regulated gene induction in isolated hepatic stellate cells. Using a portion of the human Nqo1 promoter consisting of an ARE imbedded TRE, it was demonstrated that while the ARE was responsible for mediating inducible gene expression in response to the electrophiles 4-HNE and tBHQ, the TRE was refractory to induction by either electrophiles or PMA. It was demonstrated that stellate cells possess nuclear TRE-binding proteins that were identified as JunB, JunD, Fra1, and Fra2, which were unaffected by either electrophiles or PMA treatment. This report demonstrates that, in contrast to the ARE, the TRE and its binding cognate AP-1 did not mediate independent gene induction in hepatic stellate cells. This observation is significant given the presumed importance attributed to AP-1 in mediating profibrogenic gene expression

  8. Comparative Effectiveness of Low-Volume Time-Efficient Resistance Training Versus Endurance Training in Patients With Heart Failure

    DEFF Research Database (Denmark)

    Munch, Gregers Winding; Birgitte Rosenmeier, Jaya; Petersen, Morten

    2018-01-01

    -related quality of life in lower New York Heart Association-stage HF patients, despite less time required as well as lower energy expenditure during TRE than during AMC. Therefore, TRE might represent a time-efficient exercise modality for improving adherence to exercise in patients with class I-II HF.......PURPOSE: Cardiorespiratory fitness is positively related to heart failure (HF) prognosis, but lack of time and low energy are barriers for adherence to exercise. We, therefore, compared the effect of low-volume time-based resistance exercise training (TRE) with aerobic moderate-intensity cycling...... (AMC) on maximal and submaximal exercise capacity, health-related quality of life, and vascular function. METHODS: Twenty-eight HF patients (New York Heart Association class I-II) performed AMC (n = 14) or TRE (n = 14). Maximal and submaximal exercise capacity, health-related quality of life...

  9. Structural and functional analysis of an enhancer GPEI having a phorbol 12-O-tetradecanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene.

    Science.gov (United States)

    Okuda, A; Imagawa, M; Maeda, Y; Sakai, M; Muramatsu, M

    1989-10-05

    We have recently identified a typical enhancer, termed GPEI, located about 2.5 kilobases upstream from the transcription initiation site of the rat glutathione transferase P gene. Analyses of 5' and 3' deletion mutants revealed that the cis-acting sequence of GPEI contained the phorbol 12-O-tetradecanoate 13-acetate responsive element (TRE)-like sequence in it. For the maximal activity, however, GPEI required an adjacent upstream sequence of about 19 base pairs in addition to the TRE-like sequence. With the DNA binding gel-shift assay, we could detect protein(s) that specifically binds to the TRE-like sequence of GPEI fragment, which was possibly c-jun.c-fos complex or a similar protein complex. The sequence immediately upstream of the TRE-like sequence did not have any activity by itself, but augmented the latter activity by about 5-fold.

  10. An introduction to the edition of two Lemaître’s original manuscripts

    Directory of Open Access Journals (Sweden)

    Maere Catherine de

    2017-04-01

    Full Text Available The aim of this paper is to explain the contributions of G. Lemaître to Spinor Theory. At the end of the paper, we edited also, for the first time two short manuscripts: Spineurs et Quanta and Les spineurs et la physique quantique, written by Lemaître in December 1955 and in January 1956. This edition is a way of honouring Professor Michael Heller because he was the first, with Professor Odon Godart, who discovered, classified and published unedited manuscripts of G. Lemaître.

  11. Maître et Disciple

    Directory of Open Access Journals (Sweden)

    Ioan HUMĂ

    2009-10-01

    Full Text Available Abstract: Cultural values, including those of knowledge and intellectual training, do not represent hypostasis entities; only the man creates them and he is the only one who lives in a noological horizon. But this process cannot be achieved by its self. Thinkers and their disciples have always assumed great existential challenges, seeking answers to their appropriate time. The paradigm of the Master – Disciple has played a major formative role in the history of spirit.

  12. TRE ~ANGUAGE LOTTERY: PROMISES, PROMISES ...

    African Journals Online (AJOL)

    dual children, about which expressions a certain child heard and registered and with what frequency at ... scientific theorizing, suggested the need for another model, allowing d simpler account of the phenotype or .... (1) generate base structures, which are mapped to abstract S-structures including trace by tranSformations,.

  13.  Spis treści

    Directory of Open Access Journals (Sweden)

    ANNA BARTOSZEWICZ

    2015-03-01

    Full Text Available  Od Zespołu Redakcyjnego – Editorial .......................................................................................................... 7 Anna Bartoszewicz – Praktyczna realizacja Programu zapewnienia i poprawy jakości w komórkach audytu wewnętrznego na wybranych przykładach – Implementation of Quality Assurance and Improvement Program by internal audit teams on selected examples ................................................................ 9 Anna Białek-Jaworska, Natalia Nehrebecka – Struktura kapitałowa przedsiębiorstw w świetle wyników badań – Capital structure of companies in the light of research results ..................... 29 Magda Chraścina – Determinanty tworzenia rezerw oraz ich skutki bilansowo- -wynikowe na przykładzie spółek notowanych na Giełdzie Papierów Wartościowych w Warszawie – Determinants of creating provisions and their effect on the balance sheet and income statement on the example of companies listed on the Warsaw Stock Exchange .................................................................................................. 53 Małgorzata Garstka – Dobry obyczaj jako norma kształtująca zachowanie księgowych – Good practice as a norm shaping the behavior of accountants ...................... 73 Przemysław Kabalski, Joanna Szwajcar – Feminizacja studiów w zakresie rachunkowości w Polsce – przyczyny i skutki – Feminization of accounting studies in Poland – causes and consequences .. 85 Anna Kasperowicz – Znaki i kody rachunkowości w procesie komunikacji – Accounting signs and codes in the communication process .......................... 107 Marcin Kędzior – Dobrowolne stosowanie MSSF przez spółki giełdowe w wybranych krajach Europy Zachodniej – Voluntary adoption of IFRS by listed companies in selected Western European countries ................................................................................................. 123 Ewelina Zarzycka – Rola międzynarodowych kwalifikacji w procesie rozwoju i kształcenia specjalistów ds. rachunkowości zarządczej w Polsce – The role of international management accounting qualifications in the process of education and development of management accountants in Poland .... 137 Z historii rachunkowości / History of Accounting Sławomir Sojak, Monika Kowalska – Księgowość podwójna według Pacioliego i jego włoskich naśladowców z XVI i XVII wieku – Double-entry bookkeeping by Pacioli and his Italian followers in XVI–XVII century ............................................................................................ 155 Konferencje naukowe w dziedzinie rachunkowości i finansów organizowane w 2015 r. przez szkoły wyższe w Polsce – Scientific conferences in the field of accounting and finance held in 2015 by higher education institutions in Poland... ..................................................... 181 Informacja dla autorów ......................................................................................... 185 Instructions for authors.......................................................................................... 195

  14. Tre citazioni: Corazzini, Sbarbaro, Montale

    Directory of Open Access Journals (Sweden)

    Giorgio Bàrberi Squarotti

    2010-12-01

    Full Text Available Twentieth-century Italian literature is deeply rooted in the tradition. This is demonstrated by numerous examples, such as the echo of Gabriele D’Annunzio’s tragedy La fiaccola sotto il moggio (The Torch under the Bushel in a famous poem by Sandro Corazzini. Other examples include the presence of Dante’s Paradiso (Paradise in Camillo Sbarbaro’s verses and the influence of a famous episode taken from I Promessi Sposi (The Betrothed on a poem by Eugenio Montale. Indeed, great Authors’ texts are constantly reformulated, modified, distorted, and even reversed. Every time, quotations illustrate how close but also how far that indispensable past is.

  15. Vene ööhuligaan Eestis. Super-hüperüritus noortele. Lustlik ja arendav karaoke

    Index Scriptorium Estoniae

    2008-01-01

    Vene poplauljast Dima Bilanist, heliplaadist "I am a Night Hooligan" ja kontserdist 15. veebr. Tallinna Linnahallis. Muusikaüritusest "Tre supershow" 8. veebr. Tartus A. Le Coqi spordimajas (vt. www.tre.ee). Eestikeelsete lauludega lastekaraoke plaatidest (vt. www.lastekaraoke.ee)

  16. TENLAW: Tenancy Law and Housing Policy in Multi-level Europe: »Intra-team Comparison Report for DENMARK, FINLAND, SWEDEN«

    DEFF Research Database (Denmark)

    Juul-Sandberg, Jakob; Norberg, Per; Ralli, Tommi

    2015-01-01

    Komparativ analyse af den lejeretlige regulering og generelle regulering af vilkårene for udlejning af boliger i de tre nordiske EU lande. Baseret på rapporter fra hvert af de tre lande (Jakob Juul-Sandberg forfatter til rapporten fra Danmark)....

  17. A percepção dos gestores operacionais sobre os impactos gerados nos processos de trabalho após a implementação das melhores práticas de governança de TI no TRE/SC

    Directory of Open Access Journals (Sweden)

    Rosangela Klumb

    2014-08-01

    Full Text Available Este estudo objetivou compreender a percepção dos gestores operacionais da Secretaria de Tecnologia da Informação (STI do TRE/SC acerca dos impactos gerados nos processos de trabalho internos do órgão após a implementação das melhores práticas de governança de TI. Em termos metodológicos, trata-se de um estudo de caso descritivo-avaliativo, de abordagem qualitativa no que concerne às características e ao modo de investigação. Como resultados, verificou-se que até março de 2013 foram implementados oito dos 24 processos de governança de TI baseados no modelo Cobit, versão 4.1, definidos como meta do Planejamento Estratégico de TI para 2013. Concluiu-se que a percepção dos gestores é positiva em relação à governança de TI, embora existam algumas falhas, como na comunicação intra e interáreas e na centralização de informações por alguns setores.

  18. Mellem lovregulering og frivillighed

    DEFF Research Database (Denmark)

    Mailand, Mikkel

    Dette notat analyserer Corporate Social Responsibility (CSR) og Virksomhedernes Sociale Engagement i tre lande. Herunder diskuteres rammebetingelsernes betydning herfor.  Diskussionen om frivillighed eller tvang er central i CSR-debatten. Analysen i notatet viser, at aktørerne i ingen af de tre...

  19. Comparison of estimated core body temperature measured with the BioHarness and rectal temperature under several heat stress conditions.

    Science.gov (United States)

    Seo, Yongsuk; DiLeo, Travis; Powell, Jeffrey B; Kim, Jung-Hyun; Roberge, Raymond J; Coca, Aitor

    2016-08-01

    Monitoring and measuring core body temperature is important to prevent or minimize physiological strain and cognitive dysfunction for workers such as first responders (e.g., firefighters) and military personnel. The purpose of this study is to compare estimated core body temperature (Tco-est), determined by heart rate (HR) data from a wearable chest strap physiology monitor, to standard rectal thermometry (Tre) under different conditions.  Tco-est and Tre measurements were obtained in thermoneutral and heat stress conditions (high temperature and relative humidity) during four different experiments including treadmill exercise, cycling exercise, passive heat stress, and treadmill exercise while wearing personal protective equipment (PPE).  Overall, the mean Tco-est did not differ significantly from Tre across the four conditions. During exercise at low-moderate work rates under heat stress conditions, Tco-est was consistently higher than Tre at all-time points. Tco-est underestimated temperature compared to Tre at rest in heat stress conditions and at a low work rate under heat stress while wearing PPE. The mean differences between the two measurements ranged from -0.1 ± 0.4 to 0.3 ± 0.4°C and Tco-est correlated well with HR (r = 0.795 - 0.849) and mean body temperature (r = 0.637 - 0.861).  These results indicate that, the comparison of Tco-est to Tre may result in over- or underestimation which could possibly lead to heat-related illness during monitoring in certain conditions. Modifications to the current algorithm should be considered to address such issues.

  20. Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities

    Directory of Open Access Journals (Sweden)

    Miaw-Ling Chen

    2015-01-01

    Full Text Available This study was to investigate antiallergic effects of triterpenoids (Gt-TRE and polysaccharide (Gt-PS extracts from Ganoderma tsugae, using mast cell line RBL-2H3, T cell line EL4, primary T cells, and transfected RAW264.7 macrophage cells. The results showed that histamine secreted from activated RBL-2H3 mast cells was significantly suppressed by Gt-TRE but not Gt-PS. Interleukin- (IL- 4 secreted from activated EL4 cells was significantly suppressed by Gt-TRE but not Gt-PS. Further primary CD4+ T cells cultures also confirmed that Gt-TRE (5~50 µg/mL significantly suppressed Th2 cytokines IL-4 and IL-5 secretions but had no effect on Th1 cytokines IL-2 and interferon (IFN-γ. Gt-PS did not affect IL-4 and IL-5 secretions until higher doses (400, 500 µg/mL and significantly suppressed IFNγ secretions but enhanced IL-2 at these high doses. The reporter gene assay indicated that Gt-TRE inhibited but Gt-PS enhanced the transcriptional activity of NF-κB in activated transfected RAW264.7 cells and transfected EL4 cells. IL-4 secreted by this transfected EL-4 cells was also significantly decreased by Gt-TRE but not by Gt-PS, suggesting that these two fractions may exert different effects on NF-κB related cytokines expression. These data suggested that triterpenoids fraction of Ganoderma tsugae might be the main constituents to alleviate allergic asthma.

  1. An integrated TQM-model for continuous cost, process and product improvement. Konferencebidrag

    DEFF Research Database (Denmark)

    Kongsberg, Flemming

    Paperet beskriver hvorledes de tre teknikker: kvalitetsomkostningssystemer, target costing og benchmarking kan anvendes til at skabe bedre resultater i forbindelse med TQM.......Paperet beskriver hvorledes de tre teknikker: kvalitetsomkostningssystemer, target costing og benchmarking kan anvendes til at skabe bedre resultater i forbindelse med TQM....

  2. Kraski Pritshudja / Natalja Veber

    Index Scriptorium Estoniae

    Veber, Natalja

    2008-01-01

    Näitus "Peipsi maalid - vene kunstnikud" Tallinnas Lindakivi keskuses. Oma töid näitavad Tallinnas elavad Peipsiäärsest pärit Ljubov Zhukova koos tütre Valentina ja poja Jevgeniga ning Jelena Mironova koos tütre Karina Saberiga. Autoritest

  3. 400 siders sms fra emo-land

    DEFF Research Database (Denmark)

    Haarder, Jon Helt

    2009-01-01

    HENRIK LIST: KÆRE FUCKING DAGBOG 384 sider (illustreret), 250 kr. Lindhardt og Ringhof UDKOMMER I DAG Tre stjerner. Udgivelsesdato: 05.03......HENRIK LIST: KÆRE FUCKING DAGBOG 384 sider (illustreret), 250 kr. Lindhardt og Ringhof UDKOMMER I DAG Tre stjerner. Udgivelsesdato: 05.03...

  4. In vitro fermentation characteristics of two mushroom species, an herb, and their polysaccharide fractions, using chicken cecal contents as inoculum

    NARCIS (Netherlands)

    Guo, F.; Williams, B.A.; Kwakkel, R.P.; Verstegen, M.W.A.

    2003-01-01

    In vitro fermentabilities of two mushrooms (Lentinus edodes - LenS; Tremella fuciformis - TreS), an herb (Astragalus membranaceus - AstS), and their polysaccharide fractions (LenE, TreE, and AstE) were investigated using microflora from chicken ceca. Polysaccharides were extracted using the hot

  5. Otwartoźródłowe aplikacje CMS w uczelnianym systemie biblioteczno-informacyjnym: Joomla!, Omeka, SubjectPlus, a może Xibo?

    OpenAIRE

    Piotrowski, Dominik Mirosław

    2016-01-01

    Systemy zarządzania treścią (ang. content management systems, CMS) to aplikacje sieciowe odpowiedzialne za gromadzenie, zarządzanie i publikowanie różnych typów elektronicznej treści. Celem artykułu jest wskazanie na wybrane CMS typu open source w kontekście ich implementacji w roli platform do realizacji usług i transmisji specjalistycznej treści w zintegrowanej sieci bibliotecznej w obrębie uczelni, tj. w bibliotece głównej oraz w bibliotekach wydziałowych i zakładowych. W polskim piśmienni...

  6. Effects of menthol application on the skin during prolonged immersion in swimmers and controls.

    Science.gov (United States)

    Botonis, P G; Geladas, N D; Kounalakis, S N; Cherouveim, E D; Koskolou, M D

    2017-12-01

    We hypothesized that menthol application on the skin would enhance vasoconstriction of subjects immersed in cool water, which would reduce heat loss and rectal temperature (Tre) cooling rate. Furthermore, it was hypothesized that this effect would be greater in individuals acclimatized to immersion in 24 °C water, such as swimmers. Seven swimmers (SW) and seven physical education students (CON) cycled at 60% VO 2 max until Tre attained 38 °C, and were then immediately immersed in stirred water maintained at 24 °C on two occasions: without (NM) and with (M; 4.6 g per 100 mL of water) whole-body skin application of menthol cream. Heart rate, Tre, proximal-distal skin temperature gradient, oxygen uptake (VO 2 ), electromyographic activity (EMG), and thermal sensation were measured. Tre reduction was similar among SW and CON in NM and CON in M (-0.71±0.31 °C in average), while it was smaller for SW in M (-0.37±0.18 °C, P immersion reduces heat loss, but defends Tre decline more effectively in swimmers than in non-swimmers. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. The Build-Up Course of Visuo-Motor and Audio-Motor Temporal Recalibration

    Directory of Open Access Journals (Sweden)

    Yoshimori Sugano

    2011-10-01

    Full Text Available The sensorimotor timing is recalibrated after a brief exposure to a delayed feedback of voluntary actions (temporal recalibration effect: TRE (Heron et al., 2009; Stetson et al., 2006; Sugano et al., 2010. We introduce a new paradigm, namely ‘synchronous tapping’ (ST which allows us to investigate how the TRE builds up during adaptation. In each experimental trial, participants were repeatedly exposed to a constant lag (∼150 ms between their voluntary action (pressing a mouse and a feedback stimulus (a visual flash / an auditory click 10 times. Immediately after that, they performed a ST task with the same stimulus as a pace signal (7 flashes / clicks. A subjective ‘no-delay condition’ (∼50 ms served as control. The TRE manifested itself as a change in the tap-stimulus asynchrony that compensated the exposed lag (eg, after lag adaptation, the tap preceded the stimulus more than in control and built up quickly (∼3–6 trials, ∼23–45 sec in both the visuo- and audio-motor domain. The audio-motor TRE was bigger and built-up faster than the visuo-motor one. To conclude, the TRE is comparable between visuo- and audio-motor domain, though they are slightly different in size and build-up rate.

  8. 2018-IJBCS-Article-François Matty

    African Journals Online (AJOL)

    hp

    pour une meilleure utilisation des terres de la vallée de Tamra. © 2014 International ... thermiques entre les maxima et les minima annuels sont .... matériau est bariolé ocre rougeâtre et jaunâtre ..... existantes afin de favoriser le stockage des.

  9. Audio-motor but not visuo-motor temporal recalibration speeds up sensory processing

    NARCIS (Netherlands)

    Sugano, Y.; Keetels, M.N.; Vroomen, J.; Mouraux, André

    2017-01-01

    Perception of synchrony between one's own action (a finger tap) and the sensory feedback thereof (a visual flash or an auditory pip) can be recalibrated after exposure to an artificially inserted delay between them (temporal recalibration effect: TRE). TRE might be mediated by a compensatory shift

  10. Sådan bliver whistleblowing moralsk tilladeligt

    DEFF Research Database (Denmark)

    Rønn, Kira Vrist

    2017-01-01

    Der er brug for en mere nuanceret debat om det moralske aspekt af whistleblowing. Derfor er her tre kriterier, der kan bruges som rettesnore......Der er brug for en mere nuanceret debat om det moralske aspekt af whistleblowing. Derfor er her tre kriterier, der kan bruges som rettesnore...

  11. Udvikling af arbejdet i callcentre - sådan gik det

    DEFF Research Database (Denmark)

    Wiegman, Inger-Marie; Møller, Niels

    Et treårigt projekt om arbejdet i callcentre blev afsluttet i 2006. Projektet startede i 2003 og gennemførte udvikling af arbejdet, organisationen og kompetencerne i tre store danske virksomheder. Det var Nykredit, Danske Bank og TDC, som har deres egne callcentre. 700 medarbejdere og ledere deltog...

  12. Drivsel - drift og trivsel i callcentre

    DEFF Research Database (Denmark)

    Møller, Niels; Wiegman, Inger-Marie; Pedersen, Jens Voxtrup

    Bogen fortæller om resultaterne af et treårigt projekt om arbejdet i callcentre som blev afsluttet i 2006. Projektet ”Callcentre – udvikling af arbejdet” gennemførte udvikling af arbejdet, arbejdsorganiseringen og kompetencerne i tre store danske virksomheder Nykredit, Danske Bank og TDC, som har...

  13. Fichte

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2016-01-01

    af en udefrakommende andethed. Disse tre temaer behandles med udgangspunkt i tre tekster, som Fichte skrev og publicerede umiddelbart før og under sin ansættelse som professor ved universitetet i Jena i perioden 1794- 1799: "Über den Begriff der Wissenschaftslehre oder der sogenannten Philosophie...

  14. Led strategisk med 3 F'er

    DEFF Research Database (Denmark)

    Klausen, Kurt Klaudi

    2017-01-01

    Artiklen gennemgår kort de tre F'er: at fremskrive, forudse og forestille som strategiske værktøjer til strategic forecast......Artiklen gennemgår kort de tre F'er: at fremskrive, forudse og forestille som strategiske værktøjer til strategic forecast...

  15. Engineered Trehalose Permeable to Mammalian Cells.

    Directory of Open Access Journals (Sweden)

    Alireza Abazari

    Full Text Available Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and extracellular trehalose has been shown to confer improved tolerance against freezing and desiccation. Since mammalian cells do not synthesize nor import trehalose, the development of novel methods for efficient intracellular delivery of trehalose has been an ongoing investigation. Herein, we studied the membrane permeability of engineered lipophilic derivatives of trehalose. Trehalose conjugated with 6 acetyl groups (trehalose hexaacetate or 6-O-Ac-Tre demonstrated superior permeability in rat hepatocytes compared with regular trehalose, trehalose diacetate (2-O-Ac-Tre and trehalose tetraacetate (4-O-Ac-Tre. Once in the cell, intracellular esterases hydrolyzed the 6-O-Ac-Tre molecules, releasing free trehalose into the cytoplasm. The total concentration of intracellular trehalose (plus acetylated variants reached as high as 10 fold the extracellular concentration of 6-O-Ac-Tre, attaining concentrations suitable for applications in biopreservation. To describe this accumulation phenomenon, a diffusion-reaction model was proposed and the permeability and reaction kinetics of 6-O-Ac-Tre were determined by fitting to experimental data. Further studies suggested that the impact of the loading and the presence of intracellular trehalose on cellular viability and function were negligible. Engineering of trehalose chemical structure rather than manipulating the cell, is an innocuous, cell-friendly method for trehalose delivery, with demonstrated potential for trehalose loading in different types of cells and cell lines, and can facilitate the wide-spread application of trehalose as an intracellular protective agent in biopreservation studies.

  16. Det dynamiske drama

    DEFF Research Database (Denmark)

    Schneider, Magnus Tessing

    2006-01-01

    Artiklen behandler forskydningerne i Jan Kotts tre læsninger af A Midsummer Night's Dream fra hhv. 1964 ('Titania and the Ass's Head'), 1981 ('The Bottom Translation') og 1993 ('Bottom and the Boys'). Da de er skrevet på baggrund af forskellige historiske situationer, repræsenterer de tre essays ...

  17. Barriers to healthcare seeking, beliefs about cancer and the role of socio-economic position. A Danish population-based study

    DEFF Research Database (Denmark)

    Hvidberg, Line; Wulff, Christian Nielsen; Pedersen, Anette Fischer

    2014-01-01

    besvaret den danske version af måleredskabet ”Awareness and Beliefs about Cancer”. Måleredskabet inkluderer bl.a. fire udsagn om forventede barrierer for lægesøgning samt tre positive og tre negative forestillinger om kræft. Resultaterne viser, at personer med lavt uddannelsesniveau og med lav...

  18. Hvordan foregår mesterlære i elitesport?

    DEFF Research Database (Denmark)

    Lund, Ole

    af afhandlingen består af et multi-case studie af tre elitesportskontekster i Danmark. De tre cases består af henholdsvis en dame dobbeltsculler, et mandligt trampolin-synkron-par og et kvindeligt håndboldhold. Disse konstellationer befinder sig alle på et højt internationalt niveau. Afhandlingens...

  19. Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion.

    Directory of Open Access Journals (Sweden)

    Swarnalee Dutta

    Full Text Available The outcome of an interaction between plant growth promoting rhizobacteria and plants may depend on the chemical composition of root exudates (REs. We report the colonization of tobacco, and not groundnut, roots by a non-rhizospheric Bacillus cereus (MTCC 430. There was a differential alteration in the cell wall components of B. cereus in response to the REs from tobacco and groundnut. Attenuated total reflectance infrared spectroscopy revealed a split in amide I region of B. cereus cells exposed to tobacco-root exudates (TRE, compared to those exposed to groundnut-root exudates (GRE. In addition, changes in exopolysaccharides and lipid-packing were observed in B. cereus grown in TRE-amended minimal media that were not detectable in GRE-amended media. Cell-wall proteome analyses revealed upregulation of oxidative stress-related alkyl hydroperoxide reductase, and DNA-protecting protein chain (Dlp-2, in response to GRE and TRE, respectively. Metabolism-related enzymes like 2-amino-3-ketobutyrate coenzyme A ligase and 2-methylcitrate dehydratase and a 60 kDa chaperonin were up-regulated in response to TRE and GRE. In response to B. cereus, the plant roots altered their exudate-chemodiversity with respect to carbohydrates, organic acids, alkanes, and polyols. TRE-induced changes in surface components of B. cereus may contribute to successful root colonization and subsequent plant growth promotion.

  20. Partial oxidation of landfill leachate in supercritical water: Optimization by response surface methodology

    International Nuclear Information System (INIS)

    Gong, Yanmeng; Wang, Shuzhong; Xu, Haidong; Guo, Yang; Tang, Xingying

    2015-01-01

    Highlights: • Partial oxidation of landfill leachate in supercritical water was investigated. • The process was optimized by Box–Behnken design and response surface methodology. • GY H2 , TRE and CR could exhibit up to 14.32 mmol·gTOC −1 , 82.54% and 94.56%. • Small amounts of oxidant can decrease the generation of tar and char. - Abstract: To achieve the maximum H 2 yield (GY H2 ), TOC removal rate (TRE) and carbon recovery rate (CR), response surface methodology was applied to optimize the process parameters for supercritical water partial oxidation (SWPO) of landfill leachate in a batch reactor. Quadratic polynomial models for GY H2 , CR and TRE were established with Box–Behnken design. GY H2 , CR and TRE reached up to 14.32 mmol·gTOC −1 , 82.54% and 94.56% under optimum conditions, respectively. TRE was invariably above 91.87%. In contrast, TC removal rate (TR) only changed from 8.76% to 32.98%. Furthermore, carbonate and bicarbonate were the most abundant carbonaceous substances in product, whereas CO 2 and H 2 were the most abundant gaseous products. As a product of nitrogen-containing organics, NH 3 has an important effect on gas composition. The carbon balance cannot be reached duo to the formation of tar and char. CR increased with the increase of temperature and oxidation coefficient

  1. Deconstructing learning games as fun, educative and realistic

    DEFF Research Database (Denmark)

    Duus Henriksen, Thomas

    2011-01-01

    Denne artikel udfordrer de tre kongstanker inden for læringsspilsforskning og praksis om, at læringsspil skal være hhv. sjove, indholdsrige og realistiske, og fremviser en række af de alternativer, som bliver tilgængelige, når man tillader sig at forlade disse tre dominerende konstruktioner....

  2. Genetisk variation og langt liv

    DEFF Research Database (Denmark)

    Sørensen, Mette

    2013-01-01

    andre ikke gør. I dette ph.d.-projekt undersøgte vi sammenhængen mellem levetid og variation i tre biologiske skadesprocesser. De tre er: antioxidanter, væksthormon/insulin-signalering og DNA-reparation. Vi fandt nye genvariationer, hvoraf nogle har positiv indflydelse på chancen for at blive meget...

  3. Energirenovering af parcelhuse

    DEFF Research Database (Denmark)

    Aggerholm, Søren

    af de tre huse består i efterisolering af lofter op til 300 mm, udskiftning af almindelige termoruder til energiruder, og installation af solvarmeanlæg til produktion af varmt brugsvand. I de tre huse er der ved energirenoveringen opnået en reduktion af energiforbruget på 16-22 procent. Rapporten...

  4. Glycogen Phosphorylase and Glycogen Synthase: Gene Cloning and Expression Analysis Reveal Their Role in Trehalose Metabolism in the Brown Planthopper, Nilaparvata lugens Stål (Hemiptera: Delphacidae).

    Science.gov (United States)

    Zhang, Lu; Wang, Huijuan; Chen, Jianyi; Shen, Qida; Wang, Shigui; Xu, Hongxing; Tang, Bin

    2017-01-01

    RNA interference has been used to study insects' gene function and regulation. Glycogen synthase (GS) and glycogen phosphorylase (GP) are two key enzymes in carbohydrates' conversion in insects. Glycogen content and GP and GS gene expression in several tissues and developmental stages of the Brown planthopper Nilaparvata lugens Stål (Hemiptera: Delphacidae) were analyzed in the present study, using quantitative reverse-transcription polymerase chain reaction to determine their response to double-stranded trehalases (dsTREs), trehalose-6-phosphate synthases (dsTPSs), and validamycin injection. The highest expression of both genes was detected in the wing bud, followed by leg and head tissues, and different expression patterns were shown across the developmental stages analyzed. Glycogen content significantly decreased 48 and 72 h after dsTPSs injection and 48 h after dsTREs injection. GP expression increased 48 h after dsTREs and dsTPSs injection and significantly decreased 72 h after dsTPSs, dsTRE1-1, and dsTRE1-2 injection. GS expression significantly decreased 48 h after dsTPS2 and dsTRE2 injection and 72 h after dsTRE1-1 and dsTRE1-2 injection. GP and GS expression and glycogen content significantly decreased 48 h after validamycin injection. The GP activity significantly decreased 48 h after validamycin injection, while GS activities of dsTPS1 and dsTRE2 injection groups were significantly higher than that of double-stranded GFP (dsGFP) 48 h after injection, respectively. Thus, glycogen is synthesized, released, and degraded across several insect tissues according to the need to maintain stable trehalose levels. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America.

  5. SU-F-J-88: Comparison of Two Deformable Image Registration Algorithms for CT-To-CT Contour Propagation

    Energy Technology Data Exchange (ETDEWEB)

    Gopal, A; Xu, H; Chen, S [University of Maryland School of Medicine, Columbia, MD (United States)

    2016-06-15

    Purpose: To compare the contour propagation accuracy of two deformable image registration (DIR) algorithms in the Raystation treatment planning system – the “Hybrid” algorithm based on image intensities and anatomical information; and the “Biomechanical” algorithm based on linear anatomical elasticity and finite element modeling. Methods: Both DIR algorithms were used for CT-to-CT deformation for 20 lung radiation therapy patients that underwent treatment plan revisions. Deformation accuracy was evaluated using landmark tracking to measure the target registration error (TRE) and inverse consistency error (ICE). The deformed contours were also evaluated against physician drawn contours using Dice similarity coefficients (DSC). Contour propagation was qualitatively assessed using a visual quality score assigned by physicians, and a refinement quality score (0TRE = 3.2 mm) performed better than the biomechanical DIR (TRE = 4.3 mm) with landmark tracking. Both algorithms had comparable DSC (DSC > 0.9 for lungs, > 0.85 for heart, > 0.8 for liver) and similar qualitative assessments (VQS < 0.35, RQS > 0.75 for lungs). When anatomical structures were used to control the deformation, the DSC improved more significantly for the biomechanical DIR compared to the hybrid DIR, while the VQS and RQS improved only for the controlling structures. However, while the inclusion of controlling structures improved the TRE for the hybrid DIR, it increased the TRE for the biomechanical DIR. Conclusion: The hybrid DIR was found to perform slightly better than the biomechanical DIR based on lower TRE while the DSC, VQS, and RQS studies yielded comparable results for both. The use of controlling structures showed considerable improvement in the hybrid DIR results and is recommended for clinical use in

  6. A Preclinical Assessment of Early Continuous Passive Motion and Treadmill Therapeutic Exercises for Generating Chondroprotective Effects After Anterior Cruciate Ligament Rupture.

    Science.gov (United States)

    Chang, Nai-Jen; Lee, Kuan-Wei; Chu, Chih-Jou; Shie, Ming-You; Chou, Pei-Hsi; Lin, Chih-Chan; Liang, Peir-In

    2017-08-01

    Anterior cruciate ligament (ACL) injury is a well-known risk factor for the development of posttraumatic osteoarthritis (PTOA). However, whether using continuous passive motion (CPM) with or without additional treadmill exercise (TRE) in early ACL injury might provide chondroprotective effects and further decrease the risk of PTOA has yet to be determined. CPM may offer an enhanced chondroprotective effect, but TRE may attenuate that effect due to the mechanical stress on the joint and inflammatory cytokines in the joint. Controlled laboratory study. Thirty adult New Zealand White male rabbits were randomly allocated to sedentary (SED), CPM, TRE, or CPM+TRE groups. Each rabbit underwent an ACL transection (ACLT) on the right knee, with the contralateral knee used as an internal control (sham). The 4 joint surfaces (ie, medial and lateral femoral condyles and tibial plateaus) were evaluated 4 weeks after surgery for gross appearance, histological characteristics, and quantitative osteoarthritis (OA) scores. Overall, at the end of testing, the CPM group experienced the best protective therapeutic effects in all compartments. In gross appearance, CPM resulted in normal articular surfaces, while the TRE and SED groups exhibited surface abrasion. Histological analysis showed significant differences in articular cartilage status. The CPM group had significantly better histological OA scores ( P CPM+TRE group displayed visible pathological changes in the superficial cartilage, indicating that early loading exercise may contribute to osteoarthritis. The sham treatment showed no difference in the changes in all compartments between groups. Immediate CPM therapy produces a superior in situ microenvironment for reducing the occurrence of PTOA after ACL injury without reconstruction in rabbits. These data suggest that immediate application of CPM therapy may be necessary to create a sound microenvironment in joints and possibly to decrease the risk of PTOA without or while

  7. Egens sundhedsproblemer på grundvandsnære jorde

    DEFF Research Database (Denmark)

    Callesen, Ingeborg; Jørgensen, Bruno Bilde; Fischer, Lene

    2017-01-01

    , at klimatiske forandringer med stigende og mere svingende nedbørsmængder kunne være en forklaring på de observerede pludselige skader. Fire deltagende distrikter udpegede hver tre usunde og tre sunde bevoksninger, som blev genstand for en lokalitetsanalyse samt måling af vandstand i 2015 til 2017. Forekomst af...

  8. Immunogenicity evaluation of MS2 phage-mediated chimeric nanoparticle displaying an immunodominant B cell epitope of foot-and-mouth disease virus

    Directory of Open Access Journals (Sweden)

    Guoqiang Wang

    2018-05-01

    Full Text Available Foot-and-mouth disease (FMD is a highly contagious disease of cloven-hoofed animals that has caused tremendous economic losses worldwide. In this study, we designed a chimeric nanoparticles (CNPs vaccine that displays the predominant epitope of the serotype O foot-and-mouth disease virus (FMDV VP1 131-160 on the surface of MS2 phage. The recombinant protein was expressed in Escherichia Coli and can self-assemble into CNPs with diameter at 25–30 nm in vitro. A tandem repeat peptide epitopes (TRE was prepared as control. Mice were immunized with CNPs, TRE and commercialized synthetic peptide vaccines (PepVac, respectively. The ELISA results showed that CNPs stimulated a little higher specific antibody levels to PepVac, but was significantly higher than the TRE groups. Moreover, the results from specific IFN-γ responses and lymphocyte proliferation test indicated that CNP immunized mice exhibited significantly enhanced cellular immune response compared to TRE. These results suggested that the CNPs constructed in current study could be a potential alternative vaccine in future FMDV control.

  9. Efficacy of independence sampling in replica exchange simulations of ordered and disordered proteins.

    Science.gov (United States)

    Lee, Kuo Hao; Chen, Jianhan

    2017-11-15

    Recasting temperature replica exchange (T-RE) as a special case of Gibbs sampling has led to a simple and efficient scheme for enhanced mixing (Chodera and Shirts, J. Chem. Phys., 2011, 135, 194110). To critically examine if T-RE with independence sampling (T-REis) improves conformational sampling, we performed T-RE and T-REis simulations of ordered and disordered proteins using coarse-grained and atomistic models. The results demonstrate that T-REis effectively increase the replica mobility in temperatures space with minimal computational overhead, especially for folded proteins. However, enhanced mixing does not translate well into improved conformational sampling. The convergences of thermodynamic properties interested are similar, with slight improvements for T-REis of ordered systems. The study re-affirms the efficiency of T-RE does not appear to be limited by temperature diffusion, but by the inherent rates of spontaneous large-scale conformational re-arrangements. Due to its simplicity and efficacy of enhanced mixing, T-REis is expected to be more effective when incorporated with various Hamiltonian-RE protocols. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  10. Vapor cycle energy system for implantable circulatory assist devices. Annual progress report Jul 1974--Jun 1975

    International Nuclear Information System (INIS)

    Hagen, K.G.

    1975-06-01

    The report describes the development status of a heart assist system driven by a nuclear fueled, electronically controlled vapor cycle engine termed the tidal regenerator engine (TRE). The TRE pressurization (typically from 5-160 psia) is controlled by a torque motor coupled to a displacer. The electrical power for the sensor, electronic logic and actuator is provided by a thermoelectric module interposed between the engine superheater and boiler. The TRE is direct coupled to an assist blood pump which also acts as a blood-cooled heat exchanger, pressure-volume transformer and sensor for the electronic logic. Engine efficiencies in excess of 14% have been demonstrated. Efficiency values as high as 13% have been achieved to date

  11. Bourse de perfectionnement professionnel : Agriculture et sécurité ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 août 2017 ... Type. Subventions. Admissibilité. Pour être admissible, vous devez remplir les conditions suivantes : Être citoyen canadien, résident permanent du Canada ou citoyen d'un pays en développement et détenir un permis de travail canadien valide jusqu'au 30 septembre 2018;; Être inscrit au doctorat dans ...

  12. L'architecture évolutive de la gouvernance locale scandinave

    DEFF Research Database (Denmark)

    Bogason, Peter; Pierre, Jon; Aarsæther, Nils

    2006-01-01

    Diskussion af fremkomsten af governance i Skandinavien, der ses som et kerneområde for fænomenet. De tre landes lokale styreformer gennemgås fra det perspektiv........Diskussion af fremkomsten af governance i Skandinavien, der ses som et kerneområde for fænomenet. De tre landes lokale styreformer gennemgås fra det perspektiv.....

  13. Nye militære trends i den syriske borgerkrig

    DEFF Research Database (Denmark)

    Engen, Torben Toftgaard; Kjellund, Jon

    2018-01-01

    I den flerårige syriske borgerkrig har der fundet tre nye militære trends sted, der peger imod, at fremtidens landmilitære kampplads vil være væsensforskellig fra indsatserne i Irak og Afghanistan. Denne rapport analyserer de tre trends inden for digitaliseringen af den hybride krigsførelse og ka...

  14. Partial oxidation of landfill leachate in supercritical water: Optimization by response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Yanmeng; Wang, Shuzhong; Xu, Haidong; Guo, Yang; Tang, Xingying

    2015-09-15

    Highlights: • Partial oxidation of landfill leachate in supercritical water was investigated. • The process was optimized by Box–Behnken design and response surface methodology. • GY{sub H2}, TRE and CR could exhibit up to 14.32 mmol·gTOC{sup −1}, 82.54% and 94.56%. • Small amounts of oxidant can decrease the generation of tar and char. - Abstract: To achieve the maximum H{sub 2} yield (GY{sub H2}), TOC removal rate (TRE) and carbon recovery rate (CR), response surface methodology was applied to optimize the process parameters for supercritical water partial oxidation (SWPO) of landfill leachate in a batch reactor. Quadratic polynomial models for GY{sub H2}, CR and TRE were established with Box–Behnken design. GY{sub H2}, CR and TRE reached up to 14.32 mmol·gTOC{sup −1}, 82.54% and 94.56% under optimum conditions, respectively. TRE was invariably above 91.87%. In contrast, TC removal rate (TR) only changed from 8.76% to 32.98%. Furthermore, carbonate and bicarbonate were the most abundant carbonaceous substances in product, whereas CO{sub 2} and H{sub 2} were the most abundant gaseous products. As a product of nitrogen-containing organics, NH{sub 3} has an important effect on gas composition. The carbon balance cannot be reached duo to the formation of tar and char. CR increased with the increase of temperature and oxidation coefficient.

  15. Deliriumincidens på tre danske intensivafsnit

    DEFF Research Database (Denmark)

    Svenningsen, Helle; Tønnesen, Else

    2009-01-01

    sedated patients (with or without medication) had a 10-fold increased risk of ICU-delirium. Age was not associated with any difference in incidence. Patients were mostly unsedated when scored to have delirium; no sedation medication significantly increased ICU-delirium. Fentanyl used as analgesic showed...

  16. Théâtre les 50

    CERN Multimedia

    Théâtre les 50

    2011-01-01

    Vendredi 4 février à 20h30 Le Groupe Théâtral Gessien présente: BALLADE ANDALOUSE Textes : Frederico Garcia Lorca Avec Roger Grosrey Accompagnement à la guitare : David Maurer et Sophie Maurer Ce spectacle est l’occasion d’entrer poétiquement dans l’année 2011 en compagnie de Federico Garcia Lorca.   Quand un homme, une fois, se donne, pleinement et en vérité, à l’appel de ce qu’il est ici et maintenant, il se livre pour toujours, et de partout on le découvre. Poète de naissance, irrémédiablement et ne se voulant pas autre chose, s’étant situé une fois pour toutes du côté de ceux qui n’ont rien et à qui on dénie jusqu’à la tranquillité du n&...

  17. Théâtre de Carouge

    CERN Multimedia

    Théâtre de Carouge

    2012-01-01

    UBU ENCHAÎNE D'alfred Jarry Mise en scène de Dan Jemmett Cornegidouille, le Père Ubu ne veut plus dire le mot ! Las d'être roi, il se fait esclave. Despote entravé par les fers, il tuera quand même à tour de bras, entraînant au passage l'aliénation volontaire des "Hommes libres", avant de finir sur une galère l'emportant n'importe ou, mais ailleurs ! En s'emparant de ce chef-d'oeuvre pataphysique, Dan Jemmett offre à Eric Cantonna un rôle à sa (dé)mesure. Jusqu’au 25 janvier 2012 Salle François-Simon - Première en Suisse SEPT CONTES DIVERS Mise en scène de Jean-Claude Issenmann Jean-Claude Issenmann a besoin de toucher les choses, de griffonner des silhouettes, d'esquisser des lieux et d'imaginer des décors (g...

  18. Le tre età del riso

    Directory of Open Access Journals (Sweden)

    Elisabetta Abignente

    2017-02-01

    Full Text Available Questo saggio introduttivo prova una sistemazione teorica della questione del­l’umo­­rismo (nella sua fondamentale articolazione tra forme parodiche, satiriche e antinarrative e propone un sommario excursus attraverso le diverse sezioni del volume, risultato del Convegno Compalit Chi ride ultimo: Parodia satira umorismi (Napoli, 16-18 dicembre 2015: dalle “lezioni magistrali” comprese nella prima alle relazioni sviluppate nelle altre cinque, e incentrate rispettivamente su: una verifica dell’attuale efficacia euristica della concezione bachtiniana; un’indagine sulle parodie del sacro nella letteratura e nelle arti contemporanee; una genealogia delle scritture antinarrative riconducibili all’archetipo settecentesco del Tristram Shandy di Sterne; una morfologia delle opere letterarie segnate da «risata dianoetica» e umori apocalittici; un attraversamento transmediale dei «palinsesti» novecenteschi, con particolare riferimento al teatro e al cinema (ma guardando anche alla televisione, al fumetto e al web.

  19. Kinas kapabiliteter i cyberspace

    DEFF Research Database (Denmark)

    Hjortdal, Magnus

    Briefet præsenterer tre årsager til at stater anvender deres evner i cyberspace på en offensiv måde, og viser at cyberspace er – og vil blive ved med at være – et afgørende element i Kinas strategi for opstigningen i det internationale system. De tre årsager er: 1) afskrækkelse via infiltration, ...

  20. Den signede dag

    DEFF Research Database (Denmark)

    Balslev-Clausen, Peter

    2010-01-01

    Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition.......Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition....

  1. Tro og Viden

    DEFF Research Database (Denmark)

    Pedersen, Jens Olaf Pepke

    2015-01-01

    tid at være forskere og troende kristne. Georges Lemaître kunne således som professor i astronomi udvikle Big Bang teorien, samtidig med at han var katolsk præst.Det har affødt en kritisk kommentar (den 24. juli) fra Torben Smith Sørensen, der har opfattet det, som om Lemaître blandede naturvidenskab...

  2. Måltidsvaner for voksne med kort uddannelse 2005-2008

    DEFF Research Database (Denmark)

    Christensen, Lene Møller; Kørup, Karsten; Trolle, Ellen

    tre hovedmåltider og tre mellemmåltider samt hverdag/weekend. Resultaterne vises for mænd og kvinder separat og samlet. Rapporten er baseret på data fra Den nationale undersøgelse af danskernes kostvaner og fysiske aktivitet indsamlet i 2005-2008. I alt 537 mænd og 535 kvinder i alderen 20-75 år...

  3. Participation des agriculteurs à la conception d’un projet de reconversion à l’irrigation localisée dans le périmètre du Tadla

    Directory of Open Access Journals (Sweden)

    Maha Hadioui

    2014-11-01

    Full Text Available Les périmètres de grande hydraulique au Maroc utilisent pour l’essentiel l’irrigation gravitaire ou l’aspersion. Dans ces périmètres, plusieurs projets pilotes de reconversion collective à l’irrigation localisée sont en cours. Nous avons mené une étude sur la participation des agriculteurs à la conception d’un projet pilote dans le périmètre du Tadla. Le projet ne prévoyait pas initialement de gérer l’aménagement de l’irrigation localisée au niveau des parcelles, mais cet aspect a été inclus par la suite. Les associations d’usagers de l’eau ont été redynamisées, avec notamment la nomination de chefs de bloc, qui doivent jouer le rôle d’intermédiaires entre les agriculteurs et le conseil d’administration. De nombreuses réunions d’information et de coordination ont été organisées. Ces différentes initiatives ont permis une bonne qualité de dialogue entre une minorité d’agriculteurs et les acteurs de développement en charge du projet. Cependant, une majorité d’agriculteurs n’ont pas ou peu participé aux réunions et aux visites de formation sur l’irrigation localisée, et ce, pour trois principales raisons : 1 une majorité des exploitations enquêtées sont gérées par plusieurs héritiers qui exploitent de façon indépendante des lots séparés, mais utilisent la même borne et ainsi sont peu visibles pour l’administration ; 2 l’absence de définition initiale d’une méthode explicite pour s’assurer d’une large participation ; et 3 le rôle limité qu’a joué les associations d’irrigants dans la circulation de l’information. Malgré ces limites, l’expérience a aussi été un lieu important d’apprentissage pour l’ensemble des acteurs, avec une amélioration progressive des conditions et résultats de la participation des agriculteurs.

  4. Le theatre d'Afrique noire francophone: un art tourne vers le ...

    African Journals Online (AJOL)

    Cette étude a pour objectif de porter un regard analytique sur le théâtre d'Afrique noire francophone, depuis les années d'indépendances jusqu'à nos jours, afin de mettre en relief sa contribution au développement du continent. Il est à remarquer, en effet, que ce théâtre, dans son cheminement, est essentiellement un ...

  5. Gestion intégrée de l'eau et des nutriments pour la production ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Sahel, la sécheresse et la piètre fertilité des sols limitent grandement le rendement des cultures. En 2005 et 2010, ces deux facteurs ont conduit à des pénuries alimentaires au Niger. Pourtant, des technologies novatrices comme le microdosage des engrais associé à la récupération des eaux de pluie peuvent accroître ...

  6. Correlation of structure, function and protein dynamics in GH7 cellobiohydrolases from Trichoderma atroviride, T. reesei and T. harzianum.

    Science.gov (United States)

    Borisova, Anna S; Eneyskaya, Elena V; Jana, Suvamay; Badino, Silke F; Kari, Jeppe; Amore, Antonella; Karlsson, Magnus; Hansson, Henrik; Sandgren, Mats; Himmel, Michael E; Westh, Peter; Payne, Christina M; Kulminskaya, Anna A; Ståhlberg, Jerry

    2018-01-01

    The ascomycete fungus Trichoderma reesei is the predominant source of enzymes for industrial conversion of lignocellulose. Its glycoside hydrolase family 7 cellobiohydrolase (GH7 CBH) Tre Cel7A constitutes nearly half of the enzyme cocktail by weight and is the major workhorse in the cellulose hydrolysis process. The orthologs from Trichoderma atroviride ( Tat Cel7A) and Trichoderma harzianum ( Tha Cel7A) show high sequence identity with Tre Cel7A, ~ 80%, and represent naturally evolved combinations of cellulose-binding tunnel-enclosing loop motifs, which have been suggested to influence intrinsic cellobiohydrolase properties, such as endo-initiation, processivity, and off-rate. The Tat Cel7A, Tha Cel7A, and Tre Cel7A enzymes were characterized for comparison of function. The catalytic domain of Tat Cel7A was crystallized, and two structures were determined: without ligand and with thio-cellotriose in the active site. Initial hydrolysis of bacterial cellulose was faster with Tat Cel7A than either Tha Cel7A or Tre Cel7A. In synergistic saccharification of pretreated corn stover, both Tat Cel7A and Tha Cel7A were more efficient than Tre Cel7A, although Tat Cel7A was more sensitive to thermal inactivation. Structural analyses and molecular dynamics (MD) simulations were performed to elucidate important structure/function correlations. Moreover, reverse conservation analysis (RCA) of sequence diversity revealed divergent regions of interest located outside the cellulose-binding tunnel of Trichoderma spp. GH7 CBHs. We hypothesize that the combination of loop motifs is the main determinant for the observed differences in Cel7A activity on cellulosic substrates. Fine-tuning of the loop flexibility appears to be an important evolutionary target in Trichoderma spp., a conclusion supported by the RCA data. Our results indicate that, for industrial use, it would be beneficial to combine loop motifs from Tat Cel7A with the thermostability features of Tre Cel7A. Furthermore

  7. Effects of menthol application on the skin during prolonged immersion in cool and cold water.

    Science.gov (United States)

    Botonis, P G; Kounalakis, S N; Cherouveim, E D; Koskolou, M D; Geladas, N D

    2018-03-01

    The aim of the study was to compare the effect of skin surface menthol application on rectal temperature (Tre) during prolonged immersion in cool and cold water. We hypothesized that menthol application would lead to a slower Tre decline due to the reduced heat loss as a consequence of the menthol-induced vasoconstriction and that this effect would be attenuated during cold-water immersion. Six male subjects were immersed for 55 minutes in stirred cool (24°C) or cold (14°C) water immediately after attaining a Tre of 38°C by cycling at 60% of maximum heart rate on two occasions: without (ΝM) and with (M) whole-body skin application of menthol cream. Tre, the proximal-distal skin temperature gradient, and oxygen uptake were continuously measured. ANOVA with repeated measures was employed to detect differences among variables. Significance level was set at 0.05. The area under the curve for Tre was calculated and was greater in 24°C M (-1.81 ± 8.22 a.u) compared to 24°C NM (-27.09 ± 19.09 a.u., P = .03, r = .90), 14°C NM (-18.08 ± 10.85 a.u., P = .03, r = .90), and 14°C M (-11.71 ± 12.58 a.u, P = .05, r = .81). In cool water, oxygen uptake and local vasoconstriction were increased (P ≤ .05) by 39 ± 25% and 56 ± 37%, respectively, with menthol compared to ΝM, while no differences were observed in cold water. Menthol application on the skin before prolonged immersion reduces heat loss resulting in a blunted Tre decline. However, such a response is less obvious at 14°C water immersion, possibly because high-threshold cold-sensitive fibers are already maximally recruited and the majority of cold receptors saturated. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. 2180-IJBCS-Article-epolyste Adjeffa

    African Journals Online (AJOL)

    hp

    pédologique, une analyse des indicateurs physico-chimiques et une instrumentation piézométrique du périmètre ... Sondage pédologique et analyse de sols. Pour réaliser le sondage pédologique du périmètre irrigué de ..... terres dans les pays du sahel. Diagnostic et conseil aux paysans. Collection « le point sur », 397p.

  9. A social sustainability approach to birth environment design

    DEFF Research Database (Denmark)

    Jangaard, Karin; Folmer, Mette Blicher

    RESEARCH PROCESS Measuring on welness, lifequality and experience of user involvement in all processes. DESIGN PROCESS Research and design thinking USERINVOLVEMENT Ownership of design solutions CARE MODEL / ORGANISATION Humanity, vison for care and tre......RESEARCH PROCESS Measuring on welness, lifequality and experience of user involvement in all processes. DESIGN PROCESS Research and design thinking USERINVOLVEMENT Ownership of design solutions CARE MODEL / ORGANISATION Humanity, vison for care and tre...

  10. Æstetik er tilbage som nøgle til at forstå samtiden

    DEFF Research Database (Denmark)

    Sharma, Devika

    2013-01-01

    Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" .......Casper Christensen er gakket, Hello Kitty er nuttet og konceptkunsten er interessant. Her er tre nye kategorier at forstå senkapitalismen med. I anledning af Sianne Ngais bog "Our aesthetic categories: zany, cute, interesting" ....

  11. Aktuelt om virus

    DEFF Research Database (Denmark)

    Kryger, Per; Nielsen, Steen Lykke; Hansen, Lars Monrad

    2008-01-01

    DJF har i de sidste tre år arbejdet med at klarlægge forekomst af 6 bivira i Danmark. Vores resultater viser forskelle fra år til år og med årstiderne. Resultaterne har endvidere vist, at de 6 vira har begrænset holdbarhed i døde bier. I de kommende tre år vil vores fokus være på at forebygge vir...

  12. Strategisk ledelse i det offentlige

    DEFF Research Database (Denmark)

    Klausen, Kurt Klaudi

    Bogen opsamler 10 års forskning og undervisning i strategisk ledelse i det offentlige og udvikler en ny koncepttænkning om at se ind i fremtiden og foregribe den gennem de tre F'er......Bogen opsamler 10 års forskning og undervisning i strategisk ledelse i det offentlige og udvikler en ny koncepttænkning om at se ind i fremtiden og foregribe den gennem de tre F'er...

  13. The Benefits of Being a Student of Teacher Researchers Experiences (sotre)

    Science.gov (United States)

    Eubanks, E.; Guinan, E.; Chiste, M.; Lavoie, A.

    2016-02-01

    Being a Student of Teacher Researcher Experiences (SoTRE), gets students excited for science. Eubanks brings real, current science to the classroom because of time spent in Teacher Researcher Experiences (TRE), where she works with researchers in and out of the field. She involves students in many programs including the National Oceanographic and Atmospheric Administration (NOAA), Polar TREC (Teachers and Researchers & Exploring & Collaboration), National Science Foundation (NSF) funded researchers, (EARTH) Education and Research: Testing Hypothesis, the RJ Dunlap Marine Conservation Program, C-DEBI (Center for Dark Energy Biosphere Investigations and (STARS) Sending Teachers Aboard Research Ships. Being in these programs gives students special privileges such as understanding unique research ideas, tracking tagged sharks, following daily journals written on location, taking part in cross-continental experiments, tracking real time data, exploring current research via posters or visiting universities. Furthermore, contacts made by a TRE give students an added set of resources. When doing experiments for class or advancing their education or career goals, Mrs. Eubanks helps students connect with scientists. This gives students a unique opportunity to learn from real scientists. Being part of these relationships with NOAA, Polar TREC, EARTH, RJ Dunlap, STARS and NSF funded scientists who are actively working, makes being SoTRE the ultimate learning experience. Many students have felt so strongly about the TRE relationship that they have presented at several local and international science conferences. Their message is to encourage scientists to partner with teachers. The benefits of participation in such conferences have included abstract writing and submission, travel, poster creation, networking and presentation, all tools that they will carry with them for a lifetime.

  14. Genetic evolutionary taboo search for optimal marker placement in infrared patient setup

    International Nuclear Information System (INIS)

    Riboldi, M; Baroni, G; Spadea, M F; Tagaste, B; Garibaldi, C; Cambria, R; Orecchia, R; Pedotti, A

    2007-01-01

    In infrared patient setup adequate selection of the external fiducial configuration is required for compensating inner target displacements (target registration error, TRE). Genetic algorithms (GA) and taboo search (TS) were applied in a newly designed approach to optimal marker placement: the genetic evolutionary taboo search (GETS) algorithm. In the GETS paradigm, multiple solutions are simultaneously tested in a stochastic evolutionary scheme, where taboo-based decision making and adaptive memory guide the optimization process. The GETS algorithm was tested on a group of ten prostate patients, to be compared to standard optimization and to randomly selected configurations. The changes in the optimal marker configuration, when TRE is minimized for OARs, were specifically examined. Optimal GETS configurations ensured a 26.5% mean decrease in the TRE value, versus 19.4% for conventional quasi-Newton optimization. Common features in GETS marker configurations were highlighted in the dataset of ten patients, even when multiple runs of the stochastic algorithm were performed. Including OARs in TRE minimization did not considerably affect the spatial distribution of GETS marker configurations. In conclusion, the GETS algorithm proved to be highly effective in solving the optimal marker placement problem. Further work is needed to embed site-specific deformation models in the optimization process

  15. Characterization of the Lλ phase in trehalose-stabilized dry membranes by solid-state NMR and X-ray diffraction

    International Nuclear Information System (INIS)

    Lee, C.W.B.; Das Gupta, S.K.; Mattai, J.; Shipley, G.G.; Abdel-Mageed, O.H.; Makriyannis, A.; Griffin, R.G.

    1989-01-01

    Solid-state nuclear magnetic resonance (NMR) spectroscopy and X-ray powder diffraction were used to investigate the mechanism of trehalose (TRE) stabilization of lipid bilayers. Calorimetric investigation of dry TRE-stabilized bilayers reveals a first-order phase transition at temperatures similar to the transition of hydrated lipid bilayers. X-ray diffraction studies show that dry mixtures of TRE and 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) have a lamellar structure with excess crystalline TRE being present. 2 H spectra of the choline headgroup show hindered molecular motions as compared to dry DPPC alone, and 13 C spectra of the sn-2-carbonyl show rigid lattice powder patterns indicting very little motion at the headgroup and interfacial regions. Thus, the sugar interacts extensively with the hydrophilic regions of the lipid, from the choline and the phosphate moieties in the headgroup to the glycerol and carbonyls in the interfacial region. The authors postulate that the sugar and the lipid form an extensive hydrogen-bonded network with the sugar acting as a spacer to expand the distance between lipids in the bilayer. The fluididty of the hydrophobic region in the L λ phase together with the bilayer stabilization at the headgroup contributes to membrane viability in anhydrobiotic organisms

  16. Body Temperatures During Exercise in Deconditioned Dogs: Effect of NACL and Glucose Infusion

    Science.gov (United States)

    Greenleaf, J. E.; Kruk, B.; Nazar, K.; Kaciuba-Usciko, H.

    2000-01-01

    Infusion of glucose (Glu) into normal exercising dogs attenuates the rise in rectal temperature (Delta-Tre) when compared with delta-Tre during FFA infusion or no infusion. Rates of rise and delta-=Tre levels are higher during exercise after confinement. Therefore, the purpose of this study was to determine if Glu infusion would attenuate the exercise-induced excess hyperthermia after deconditioning. Rectal and quadricep femoris muscle temperatures (Tmu) were measured in 7 male, mongrel dogs dogs (19.6 +/- SD 3.0 kg) during 90 minutes of treadmill exercise (3.1 +/-SD 0.2 W/kg) with infusion (30ml/min/kg) of 40% Glu or 0.9% NaCL before BC) and after confinement (AC) in cages (40 x 110 x 80 cm) for 8 wk. Mean (+/-SE body wt. were 19.6 +/- 1.1 kg BC and 19.5 +/- 1.1kg AC, exercise VO2 were not different (40.0 - 42.0 mi/min/kg-1). With NaCl AC, NaCl BC, GluAC, and GluBC: Delta-Tre were, 1.8, 1.4, 1.3 and 0.9C respectively; and Delta-Tmu were 2.3, 1.9, 1.6, and 1.4C. respectively (Pbody temperature with Glu infusion must affect avenues of heat dissipation.

  17. Thermoregulatory responses to skin wetting during prolonged treadmill running.

    Science.gov (United States)

    Bassett, D R; Nagle, F J; Mookerjee, S; Darr, K C; Ng, A V; Voss, S G; Napp, J P

    1987-02-01

    We examined the physiological responses to skin wetting during a 120-min level treadmill run to assess whether skin wetting would reduce the dehydration and the increase in core temperature associated with prolonged exercise. Testing was conducted in an environmental chamber (T = 29.5 degrees C, wind velocity = 3 m X sec-1) under two different humidity conditions (33 or 66% relative humidity). Ten male subjects performed two runs in each humidity condition; one served as a control run. The other included spraying the body with 50 ml of water (T = 29.5 degrees C) every 10 min. Spraying had no effect on rectal temperature (Tre), heart rate, oxygen consumption, perceived exertion, sweat loss, or percent change in plasma volume in both the humid and the dry conditions. Spraying produced a significant reduction in mean skin temperature (Tsk), which increased the (Tre - Tsk) gradient. At the same time, overall skin conductance (K) was decreased, presumably as a result of cutaneous vasoconstriction due to the low Tsk. Since heat transfer from the body's core to the skin is expressed by the equation: heat transfer = K X (Tre - Tsk) the spraying had no effect on heat transfer away from the core, and Tre remained unchanged.

  18. Presentazione

    OpenAIRE

    Ceccatelli Gurrieri, Giovanna

    2017-01-01

    Gli ultimi tre decenni hanno visto introdurre, nel dibattito sulle scienze sociali e sulla sociologia in particolare, alcuni radicali mutamenti di prospettiva, legati come è noto, in estrema sintesi, a tre principali riferimenti: la teoria dei sistemi, la fenomenologia, l’approccio ermeneutico. Si sono così andati imponendo, insieme al riconoscimento della sostanziale precarietà di ogni tentativo di conoscenza della realtà sociale, alcuni paradigmi che hanno trasformato irreversibilmente i fo...

  19. Vol. 9, No. 3, 200:3

    African Journals Online (AJOL)

    notre patient. Chez la femme, les tumeurs de l'urètre antérieur se manifestent plutôt par une urétrorragie, une dysurie, ou même par une masse perçue au méat ... Le traitement du cancer de l'urètre fait appel à la chirurgie, à la radiothérapie et à la chimiothérapie”. La Chirurgie”1o. Elle peut être conservatrice ou mutilante.

  20. C:\\Users\\AISA\\Desktop\\KALLEL SADREDDINE.xps

    African Journals Online (AJOL)

    AISA

    dans des récipients en plastique avec un couvercle de 12 cm de hauteur et présentant une base circulaire de 11cm de diamètre. Les sols sont par la suite humidifiés et déposés sur un papier filtre de 13 cm de diamètre préalablement humidifié et recevant soit des œufs de criquets soit des chenilles de Galleria mellonella.

  1. Depth-resolved registration of transesophageal echo to x-ray fluoroscopy using an inverse geometry fluoroscopy system

    Energy Technology Data Exchange (ETDEWEB)

    Hatt, Charles R. [Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53705 (United States); Tomkowiak, Michael T.; Dunkerley, David A. P.; Slagowski, Jordan M. [Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705 (United States); Funk, Tobias [Triple Ring Technologies, Inc., Newark, California 94560 (United States); Raval, Amish N. [Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53792 (United States); Speidel, Michael A., E-mail: speidel@wisc.edu [Departments of Medical Physics and Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705 (United States)

    2015-12-15

    Purpose: Image registration between standard x-ray fluoroscopy and transesophageal echocardiography (TEE) has recently been proposed. Scanning-beam digital x-ray (SBDX) is an inverse geometry fluoroscopy system designed for cardiac procedures. This study presents a method for 3D registration of SBDX and TEE images based on the tomosynthesis and 3D tracking capabilities of SBDX. Methods: The registration algorithm utilizes the stack of tomosynthetic planes produced by the SBDX system to estimate the physical 3D coordinates of salient key-points on the TEE probe. The key-points are used to arrive at an initial estimate of the probe pose, which is then refined using a 2D/3D registration method adapted for inverse geometry fluoroscopy. A phantom study was conducted to evaluate probe pose estimation accuracy relative to the ground truth, as defined by a set of coregistered fiducial markers. This experiment was conducted with varying probe poses and levels of signal difference-to-noise ratio (SDNR). Additional phantom and in vivo studies were performed to evaluate the correspondence of catheter tip positions in TEE and x-ray images following registration of the two modalities. Results: Target registration error (TRE) was used to characterize both pose estimation and registration accuracy. In the study of pose estimation accuracy, successful pose estimates (3D TRE < 5.0 mm) were obtained in 97% of cases when the SDNR was 5.9 or higher in seven out of eight poses. Under these conditions, 3D TRE was 2.32 ± 1.88 mm, and 2D (projection) TRE was 1.61 ± 1.36 mm. Probe localization error along the source-detector axis was 0.87 ± 1.31 mm. For the in vivo experiments, mean 3D TRE ranged from 2.6 to 4.6 mm and mean 2D TRE ranged from 1.1 to 1.6 mm. Anatomy extracted from the echo images appeared well aligned when projected onto the SBDX images. Conclusions: Full 6 DOF image registration between SBDX and TEE is feasible and accurate to within 5 mm. Future studies will focus on

  2. Depth-resolved registration of transesophageal echo to x-ray fluoroscopy using an inverse geometry fluoroscopy system

    International Nuclear Information System (INIS)

    Hatt, Charles R.; Tomkowiak, Michael T.; Dunkerley, David A. P.; Slagowski, Jordan M.; Funk, Tobias; Raval, Amish N.; Speidel, Michael A.

    2015-01-01

    Purpose: Image registration between standard x-ray fluoroscopy and transesophageal echocardiography (TEE) has recently been proposed. Scanning-beam digital x-ray (SBDX) is an inverse geometry fluoroscopy system designed for cardiac procedures. This study presents a method for 3D registration of SBDX and TEE images based on the tomosynthesis and 3D tracking capabilities of SBDX. Methods: The registration algorithm utilizes the stack of tomosynthetic planes produced by the SBDX system to estimate the physical 3D coordinates of salient key-points on the TEE probe. The key-points are used to arrive at an initial estimate of the probe pose, which is then refined using a 2D/3D registration method adapted for inverse geometry fluoroscopy. A phantom study was conducted to evaluate probe pose estimation accuracy relative to the ground truth, as defined by a set of coregistered fiducial markers. This experiment was conducted with varying probe poses and levels of signal difference-to-noise ratio (SDNR). Additional phantom and in vivo studies were performed to evaluate the correspondence of catheter tip positions in TEE and x-ray images following registration of the two modalities. Results: Target registration error (TRE) was used to characterize both pose estimation and registration accuracy. In the study of pose estimation accuracy, successful pose estimates (3D TRE < 5.0 mm) were obtained in 97% of cases when the SDNR was 5.9 or higher in seven out of eight poses. Under these conditions, 3D TRE was 2.32 ± 1.88 mm, and 2D (projection) TRE was 1.61 ± 1.36 mm. Probe localization error along the source-detector axis was 0.87 ± 1.31 mm. For the in vivo experiments, mean 3D TRE ranged from 2.6 to 4.6 mm and mean 2D TRE ranged from 1.1 to 1.6 mm. Anatomy extracted from the echo images appeared well aligned when projected onto the SBDX images. Conclusions: Full 6 DOF image registration between SBDX and TEE is feasible and accurate to within 5 mm. Future studies will focus on

  3. Case report

    African Journals Online (AJOL)

    ebutamanya

    11 juil. 2013 ... Les auteurs rapportent l'observation d'un patient admis dans un tableau de cellulite préseptale, avec escarre noirâtre étendue de la paupière supérieure et œdème extensif de l´hémiface, faisant suspecter une localisation palpébrale de la maladie du .... ulcère à bord réguliers de 1 à 3 cm de diamètre [9].

  4. Sécurité alimentaire et nutrition : des innovations qui aident les plus ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    28 oct. 2010 ... Le CRDI contribue à accroître la sécurité alimentaire et à améliorer la valeur nutritive des aliments depuis qu'il a vu le jour en 1970. Les recherches menées en vue de trouver des moyens de nourrier les populations pauvres ont permis de mettre au point des variétés végétales améliorées, d'accroître ...

  5. Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cells.

    OpenAIRE

    Okuda, A; Imagawa, M; Sakai, M; Muramatsu, M

    1990-01-01

    We have recently identified an enhancer, termed GPEI, in the 5'-flanking region of the rat glutathione transferase P gene, that is composed of two imperfect TPA (phorbol 12-O-tetradecanoate 13-acetate) responsive elements (TREs). Unlike other TRE-containing enhancers, GPEI exhibits a strong transcriptional enhancing activity in F9 embryonic stem cells. Mutational analyses have revealed that the high activity of GPEI is mediated by two imperfect TREs. Each TRE-like sequence has no activity by ...

  6. Building Bridges: Deference and National Interests

    DEFF Research Database (Denmark)

    Roslyng-Jensen, Palle

    2016-01-01

    Dansk, norsk og svensk tv-udsendelser om Sovjetblokken og sovjetisk politik. Der var i udsendelser fra alle tre stationer hensyntagen til sovjetiske interesser og synspunkter, men i højere grad i svenske udsendelser end i danske og norske.......Dansk, norsk og svensk tv-udsendelser om Sovjetblokken og sovjetisk politik. Der var i udsendelser fra alle tre stationer hensyntagen til sovjetiske interesser og synspunkter, men i højere grad i svenske udsendelser end i danske og norske....

  7. 1842-IJBCS-Article -MOussa Boubacar

    African Journals Online (AJOL)

    hp

    6,18%) et, d'autre part de fréquences élevées en surface productrice de ruissellement (51,3 à 90,54%). La structure en diamètre des peuplements ligneux des agroécosystèmes dégradés se caractérise par une distribution en « J renversé » avec le paramètre de forme (c) de valeur inférieure à 1. Ces résultats montrent ...

  8. Output

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2010-01-01

    Hvad får vi egentlig ud af internationale komparative undersøgelser som PISA, PIRLS og TIMSS? Hvordan påvirker de dansk uddannelsespolitik? Asterisk har talt med tre forskere med ekspertise på området.......Hvad får vi egentlig ud af internationale komparative undersøgelser som PISA, PIRLS og TIMSS? Hvordan påvirker de dansk uddannelsespolitik? Asterisk har talt med tre forskere med ekspertise på området....

  9. Iværksætter får stor lysordre til Saudi-Arabien

    DEFF Research Database (Denmark)

    Poulsen, Peter Behrensdorff; Mogensen, Ib

    2015-01-01

    Firmaet out-sider lander ordre på næsten tre millioner kroner i solcelledrevet lys til oliefirma i Saudi-Arabien. Succesen bygger på viden fra en række netop afsluttede forskningsprojekter inden for LED- og solcelleteknologi......Firmaet out-sider lander ordre på næsten tre millioner kroner i solcelledrevet lys til oliefirma i Saudi-Arabien. Succesen bygger på viden fra en række netop afsluttede forskningsprojekter inden for LED- og solcelleteknologi...

  10. Vapor cycle energy system for implantable circulatory assist devices. Final summary May--Oct 1976

    International Nuclear Information System (INIS)

    Watelet, R.P.; Ruggles, A.E.; Hagen, K.G.

    1977-03-01

    The report describes the development status of a heart assist system driven by a nuclear-fueled, electronically controlled vapor cycle engine termed the tidal regenerator engine (TRE). The TRE pressurization is controlled by a torque motor coupled to a displacer. The electrical power for the sensor, electronic logic and actuator is provided by thermoelectric modules interposed between the engine superheater and boiler. The TRE is direct-coupled to an assist blood pump which also acts as a blood-cooled heat exchanger, pressure-volume trasformer and sensor for the electronic logic. Engine cycle efficiency in excess of 14% has been demonstrated routinely. Overall system efficiency on 33 watts of over 9% has been demonstrated (implied 13% engine cycle efficiency). A binary version of this engine in the annular configuration is now being tested. The preliminary tests demonstrated 10% cycle efficiency on the first buildup which ran well and started easily

  11. Minimally invasive or open surgery for lung cancer

    DEFF Research Database (Denmark)

    Bendixen, Morten

    Denne PhD.-afhandling er udført under min ansættelse ved Klinisk Institut, Syddansk Universitet, og Hjerte- lunge- og karkirurgisk afdeling T, Odense Universitetshospital. Afhandlingen består af en oversigt og manuskripter til tre artikler. Baggrund: Siden introduktionen af video-assisteret torak......Denne PhD.-afhandling er udført under min ansættelse ved Klinisk Institut, Syddansk Universitet, og Hjerte- lunge- og karkirurgisk afdeling T, Odense Universitetshospital. Afhandlingen består af en oversigt og manuskripter til tre artikler. Baggrund: Siden introduktionen af video...... omkostningerne i forbindelse med operationerne, men ingen har lavet cost-utility analyse (CUA) til sammenligning af de to operationsteknikker. Formål: Formålet med dette studie var at sammenligne VATS lobektomi med åben lobektomi for ikke-småcellet lunge kræft (NSCLC). Vi definerede tre fokus områder. 1) Smerter...

  12. The Margins of Me

    DEFF Research Database (Denmark)

    Petersen, Sandra Lori

    2017-01-01

    Denne afhandlings hovedargument er at radioprogrammer er soundscapes – lydlandskaber – der medierer relationer på specifikke måder. Ved at analysere de tre programmer og efterfølgende sammenfatte dem udforskes det, hvordan den iboende afstand i radiomediet kombineret med det medieredes lydlige...... kvalitet er med til at forme og producere relationer i hver af disse programmers soundscapes. Kompositionen af hver af de forskellige soundscapes intensiverer lytternes oplevelser på forskellige måder, og gør at relationerne formes på forskellige måder. Således viser denne afhandling, hvordan tre...... soundscapes gør det muligt for deres lyttere at generere forskellige intense relationer, og hvordan de specifikke former, som disse relationer får, er tæt forbundne til den franske radiotradition, som de undersøgte soundscapes kommer ud af. Afhandlingen er baseret på otte måneders feltarbejde omkring tre...

  13. Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.

    Directory of Open Access Journals (Sweden)

    Anna G Drannik

    Full Text Available BACKGROUND: Upon viral recognition, innate and adaptive antiviral immune responses are initiated by genital epithelial cells (ECs to eradicate or contain viral infection. Such responses, however, are often accompanied by inflammation that contributes to acquisition and progression of sexually transmitted infections (STIs. Hence, interventions/factors enhancing antiviral protection while reducing inflammation may prove beneficial in controlling the spread of STIs. Serine antiprotease trappin-2 (Tr and its cleaved form, elafin (E, are alarm antimicrobials secreted by multiple cells, including genital epithelia. METHODOLOGY AND PRINCIPAL FINDINGS: We investigated whether and how each Tr and E (Tr/E contribute to antiviral defenses against a synthetic mimic of viral dsRNA, polyinosine-polycytidylic acid (polyI:C and vesicular stomatitis virus. We show that delivery of a replication-deficient adenovector expressing Tr gene (Ad/Tr to human endometrial epithelial cells, HEC-1A, resulted in secretion of functional Tr, whereas both Tr/E were detected in response to polyI:C. Moreover, Tr/E were found to significantly reduce viral replication by either acting directly on virus or through enhancing polyI:C-driven antiviral protection. The latter was associated with reduced levels of pro-inflammatory factors IL-8, IL-6, TNFα, lowered expression of RIG-I, MDA5 and attenuated NF-κB activation. Interestingly, enhanced polyI:C-driven antiviral protection of HEC-Ad/Tr cells was partially mediated through IRF3 activation, but not associated with higher induction of IFNβ, suggesting multiple antiviral mechanisms of Tr/E and the involvement of alternative factors or pathways. CONCLUSIONS AND SIGNIFICANCE: This is the first evidence of both Tr/E altering viral binding/entry, innate recognition and mounting of antiviral and inflammatory responses in genital ECs that could have significant implications for homeostasis of the female genital tract.

  14. Prostate multimodality image registration based on B-splines and quadrature local energy.

    Science.gov (United States)

    Mitra, Jhimli; Martí, Robert; Oliver, Arnau; Lladó, Xavier; Ghose, Soumya; Vilanova, Joan C; Meriaudeau, Fabrice

    2012-05-01

    Needle biopsy of the prostate is guided by Transrectal Ultrasound (TRUS) imaging. The TRUS images do not provide proper spatial localization of malignant tissues due to the poor sensitivity of TRUS to visualize early malignancy. Magnetic Resonance Imaging (MRI) has been shown to be sensitive for the detection of early stage malignancy, and therefore, a novel 2D deformable registration method that overlays pre-biopsy MRI onto TRUS images has been proposed. The registration method involves B-spline deformations with Normalized Mutual Information (NMI) as the similarity measure computed from the texture images obtained from the amplitude responses of the directional quadrature filter pairs. Registration accuracy of the proposed method is evaluated by computing the Dice Similarity coefficient (DSC) and 95% Hausdorff Distance (HD) values for 20 patients prostate mid-gland slices and Target Registration Error (TRE) for 18 patients only where homologous structures are visible in both the TRUS and transformed MR images. The proposed method and B-splines using NMI computed from intensities provide average TRE values of 2.64 ± 1.37 and 4.43 ± 2.77 mm respectively. Our method shows statistically significant improvement in TRE when compared with B-spline using NMI computed from intensities with Student's t test p = 0.02. The proposed method shows 1.18 times improvement over thin-plate splines registration with average TRE of 3.11 ± 2.18 mm. The mean DSC and the mean 95% HD values obtained with the proposed method of B-spline with NMI computed from texture are 0.943 ± 0.039 and 4.75 ± 2.40 mm respectively. The texture energy computed from the quadrature filter pairs provides better registration accuracy for multimodal images than raw intensities. Low TRE values of the proposed registration method add to the feasibility of it being used during TRUS-guided biopsy.

  15. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

    International Nuclear Information System (INIS)

    Hong, Wei; Li, Jinru; Wang, Bo; Chen, Linfeng; Niu, Wenyan; Yao, Zhi; Baniahmad, Aria

    2011-01-01

    Highlights: ► Corepressor Alien interacts with histone methyltransferase ESET in vivo. ► Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TRβ1. ► ESET-mediated H3K9 methylation is required for liganded TRβ1-repressed transcription. ► ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by which Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TRβ1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TRβ1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TRβ1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TRβ1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.

  16. Pour paraître à la cour : les habits de Marie-Fortunée d’Este, princesse de Conti (1731-1803 

    Directory of Open Access Journals (Sweden)

    Aurélie Chatenet-Calyste

    2012-02-01

    Full Text Available Par son mariage en 1759 avec Louis-François-Joseph de Bourbon-Conti, Marie-Fortunée d’Este (1731-1803, fille du duc italien François III d’Este de Modène, devient princesse du sang en France. L’heureuse conservation de ses comptes permet d’étudier sa garde-robe et de réfléchir aux modalités du paraître vestimentaire à la cour de la fin du XVIIIe siècle. Tenir son rang à Versailles passe pour la princesse par des dépenses élevées, le port d’étoffes luxueuses et le choix de marchands réputés. Cette étude de cas invite au-delà à envisager la spécificité de l’apparence à la cour d’une princesse devenue en 1776 une épouse séparée au budget limité. Elle interroge également les contraintes physiques de l’habit de cour à la lumière des nouvelles valeurs de confort et de liberté, tout particulièrement pour une femme d’âge mûr et maladive qui ne paraît plus guère dans le monde aulique.To be received at court: the clothes of Mary Fortunate d'Este, Princess of Conti (1731-1803 - Aurélie Chatenet-Calyste is a French researcher and also teaches at the University of Champagne-Ardenne. After passing the French high-level competitive examination for recruitment of teachers in history (In French Agrégation, she has defended her thesis “A feminine and aristocratic consumption at the end of the 18th century : Marie-Fortunée d’Este, princesse de Conti” on November the 27 th at the University of Limoges. Her researches concern gender, consumption and court history. Her recent papers are « La femme, maîtresse de maison ? », Histoire, économie et société, 2009/4, p. 21-34 ; « Une princesse et son livret de comptes : Marie-Fortunée d’Este, princesse de Conti (1731-1803 », dans Entre mémoire et histoire : écriture ordinaire et émergence de l'individu, éd. par Nicole Lemaitre et Sylvie Mouysset (édition électronique, 134e Congrès national des sociétés historiques et scientifiques

  17. Nanotechnologies : la course au nanomètre

    NARCIS (Netherlands)

    Robillard, Georges T.

    1999-01-01

    Observer et manipuler atomes et molécules pour construire des «machines moléculaires», à l’image de la nature. Telle est l’idée qui gouverne les nanotechnologies, dont les applications en biotechnologie s’annoncent porteuses: biocapteurs, ciblage des médicaments, thérapie génique...

  18. Industrija 4.0 - sadašnjost ili budućnost u Hrvatskoj

    OpenAIRE

    Matejak, Nedeljko

    2017-01-01

    Tehnološki razvoj generator je dinamičnih promjena gotovo u svim područjima koje dotiče. Jedno od područja koje prolazi kroz intenzivnu tranziciju je industrijska proizvodnja. U prilog tome govori transformacija iz treće industrijske revolucije u četvrtu, dok zapravo dio globalne ekonomije nije napravio potpunu transformaciju u treću industrijsku revoluciju. Pojam Industrija 4.0 opisuje što se nalazi na putu transformacije postojeće industrijske proizvodnje u novu, primarn...

  19. Virkeligheder i Second Life

    DEFF Research Database (Denmark)

    Jensen, Sisse Siggaard

    "Virkeligheder i Second Life" er en beretning, der bygger på tre case studier samt omfattende observationer i den virtuelle verden Second Life i perioden 2006 til 2008. Beretningen er den ene af to bøger der bygger på forskning i virtuelle verdener; de tre case studier er: Wonderful Denmark, en...... virtuel virksomhed, Literary, et virtuelt bibliotek, Times, en afdeling af en real life virksomhed. Den anden bog: "Oplevelser i en virtuel verden" omhandler den virtuelle verden EverQuest - et masserollespil....

  20. The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.

    OpenAIRE

    Diccianni, M B; Imagawa, M; Muramatsu, M

    1992-01-01

    Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE). GPEI is active in AP1-lacking F9 cells as well in AP1-containing HeLa cells. Despite GPEI's similarity to a TRE, c-jun co-transfection has only a minimal effect on transactivation. Antisense c-jun and c-fos co-transfection experiments further demonstrate the lac...

  1. Reformpædagogikken revitaliseret

    DEFF Research Database (Denmark)

    Petersen, Benedikte Vilslev; Krogh_Jespersen, Kirsten; Kirkegaard, Preben Olund

    2014-01-01

    Bogen er en introduktion til Dales norske udgivelser fra 1999 til 2011 samlet under tre hovedoverskrifter: 'Skolereformer i videnssamfundet', 'Fællesskolen - fra reproduktion af social ulighed til skolefaglig læring for alle' og 'Uddannelsesvidenskab og pædagogik'. I indledningen......Bogen er en introduktion til Dales norske udgivelser fra 1999 til 2011 samlet under tre hovedoverskrifter: 'Skolereformer i videnssamfundet', 'Fællesskolen - fra reproduktion af social ulighed til skolefaglig læring for alle' og 'Uddannelsesvidenskab og pædagogik'. I indledningen...

  2. Da Vinci Linjen

    DEFF Research Database (Denmark)

    Nissen, Poul

    Afsluttende evalueringsrapport fra følgeforskningen gennem tre år i forbindelse med dety pædagogiske arbejde på Blåbjerggårdskolens Da Vinci Linje for skolemotiverede og underpræsterende elever på 7. til 9. klassetrin.......Afsluttende evalueringsrapport fra følgeforskningen gennem tre år i forbindelse med dety pædagogiske arbejde på Blåbjerggårdskolens Da Vinci Linje for skolemotiverede og underpræsterende elever på 7. til 9. klassetrin....

  3. Instrumenter til at måle små børns trivsel

    DEFF Research Database (Denmark)

    Pontoppidan, Maiken W.; Niss, Nete Krogsgaard

    validerede instrumenter til det sociale område. Rapporten peger særligt på tre velegnede instrumenter. De har alle form af spørgeskemaer, der er letlæselige og kan udfyldes af udfyldes af forældre eller andre omsorgspersoner på under 10 min. De tre redskaber er 1) Ages & Stages Questionnaires: Social-Emotional...... (ASQ-SE), 2) Devereux Early Childhood Assessment for Infants and Toddlers (DECA-I/T), og 3) Social-Emotional Assessment/Evaluation Measure (SEAM™), Research Edition. -...

  4. Les codes du paraître dans l'espace scolaire. Les manuels de civilité en Espagne au XIXe siècle et au début du XXe

    Directory of Open Access Journals (Sweden)

    Jean-Louis Guereña

    2009-12-01

    Full Text Available L'intérêt du manuel scolaire pour l'histoire des idéologies et des mentalités n'est plus à démontrer, d'autant qu'il se trouve soumis en Espagne à un double contrôle idéologique, tant du pouvoir civil comme des instances religieuses. Vecteurs de systèmes de valeurs, les manuels scolaires servent d'instruments dans la consolidation des formes et des codes moraux et sociaux : défense de la propriété privée, conservation de l'ordre public, protection de l'ordre moral. Dans les manuels de civilité (urbanidad, la jeunesse scolarisée pouvait apprendre les normes essentielles des usages sociaux, les codes, les valeurs, les comportements et les conduites qui définissaient le modèle d'homme et de femme « civilisés » que les classes dominantes prétendaient diffuser pour asseoir leur pouvoir. La civilité vise donc une entreprise de rationalisation, de régulation des conduites, une mise en ordre qui affecte toutes les sphères de la vie, tant privée (espace domestique que publique (école, Église, rue, magasin… et, dans l’ensemble, toutes les activités (travail et loisirs. Au cœur de ce dispositif se retrouvent les notions d'usage, de bienséance (decoro, variable selon les civilisations et les peuples, et de respect : respect de soi-même en premier lieu (hygiène corporelle et tenue vestimentaire, mais toujours vis-à-vis des autres (odeurs, formes, couleurs…, respect des autres (tant êtres humains qu'animaux, et même les plantes. Ces notions sont toutes deux fondées sur l'apparence et le paraître. La norme sociale, le comportement se trouve en effet réglé par une codification sociale des usages, des rôles, et, comme l'indique un manuel, si « les animaux font ce qu'ils veulent », « les personnes font ce que commande la décence ». Nous examinons donc les différents codes du paraître à l'œuvre dans ces manuels espagnols de civilité du XIXe siècle.El interés del libro de texto para la historia de

  5. Linear motion feed through with thin wall rubber sealing element

    Science.gov (United States)

    Mikhailov, V. P.; Deulin, E. A.

    2017-07-01

    The patented linear motion feedthrough is based on elastic thin rubber walls usage being reinforced with analeptic string fixed in the middle part of the walls. The pneumatic or hydro actuators create linear movement of stock. The length of this movement is two times more the rubber wall length. This flexible wall is a sealing element of feedthrough. The main advantage of device is negligible resistance force that is less then mentioned one in sealing bellows that leads to positioning error decreasing. Nevertheless, the thin wall rubber sealing element (TRE) of the feedthrough is the main unreliable element that was the reason of this element longevity research. The theory and experimental results help to create equation for TRE longevity calculation under vacuum or extra high pressure difference action. The equation was used for TRE longevity determination for hydraulic or vacuum equipment realization also as it helps for gas flow being leaking through the cracks in thin walls of rubber sealing element of linear motion feedthrough calculation.

  6. Positive effects of cell-free porous PLGA implants and early loading exercise on hyaline cartilage regeneration in rabbits.

    Science.gov (United States)

    Chang, Nai-Jen; Lin, Chih-Chan; Shie, Ming-You; Yeh, Ming-Long; Li, Chien-Feng; Liang, Peir-In; Lee, Kuan-Wei; Shen, Pei-Hsun; Chu, Chih-Jou

    2015-12-01

    The regeneration of hyaline cartilage remains clinically challenging. Here, we evaluated the therapeutic effects of using cell-free porous poly(lactic-co-glycolic acid) (PLGA) graft implants (PGIs) along with early loading exercise to repair a full-thickness osteochondral defect. Rabbits were randomly allocated to a treadmill exercise (TRE) group or a sedentary (SED) group and were prepared as either a PGI model or an empty defect (ED) model. TRE was performed as a short-term loading exercise; SED was physical inactivity in a free cage. The knees were evaluated at 6 and 12 weeks after surgery. At the end of testing, none of the knees developed synovitis, formed osteophytes, or became infected. Macroscopically, the PGI-TRE group regenerated a smooth articular surface, with transparent new hyaline-like tissue soundly integrated with the neighboring cartilage, but the other groups remained distinct at the margins with fibrous or opaque tissues. In a micro-CT analysis, the synthesized bone volume/tissue volume (BV/TV) was significantly higher in the PGI-TRE group, which also had integrating architecture in the regeneration site. The thickness of the trabecular (subchondral) bone was improved in all groups from 6 to 12 weeks. Histologically, remarkable differences in the cartilage regeneration were visible. At week 6, compared with SED groups, the TRE groups manifested modest inflammatory cells with pro-inflammatory cytokines (i.e., TNF-α and IL-6), improved collagen alignment and higher glycosaminoglycan (GAG) content, particularly in the PGI-TRE group. At week 12, the PGI-TRE group had the best regeneration outcomes, showing the formation of hyaline-like cartilage, the development of columnar rounded chondrocytes that expressed enriched levels of collagen type II and GAG, and functionalized trabecular bone with osteocytes. In summary, the combination of implanting cell-free PLGA and performing an early loading exercise can significantly promote the full

  7. Danmarkshistorisk debat 1-3

    DEFF Research Database (Denmark)

    Jensen, Kurt Villads

    2011-01-01

    tre udsendelser på you tube http://www.youtube.com/watch?v=X_fhKCG2inQ&feature=results_main&playnext=1&list=PLF0F929EE31C1542A og på Danmarkshistorie.dk. 3 x 7-8 minutter......tre udsendelser på you tube http://www.youtube.com/watch?v=X_fhKCG2inQ&feature=results_main&playnext=1&list=PLF0F929EE31C1542A og på Danmarkshistorie.dk. 3 x 7-8 minutter...

  8. Generation of OCIAD1 inducible overexpression human embryonic stem cell line: BJNhem20-OCIAD1-Tet-On

    Directory of Open Access Journals (Sweden)

    Deeti K. Shetty

    2016-03-01

    Full Text Available Human embryonic stem cell line BJNhem20-OCIAD1-Tet-On was generated using non-viral method. The constructs pCAG-Tet-On and pTRE-Tight vector driving OCIAD1 expression were transfected using microporation procedure. pCAG-Tet-On cells can be used for inducible expression of any coding sequence cloned into pTRE-Tight vector. For example, in human embryonic stem cells, Tet-On system has been used to generate SOX2 overexpression cell line (Adachi et al., 2010.

  9. God Adfærd i Videnskaberne

    DEFF Research Database (Denmark)

    Hansen, Vagn Lundsgaard

    2006-01-01

    Hvad er videnskabelig uredelighed? Hvordan håndterer man problemet? Hvordan forebygger man det? De tre spørgsmål diskuteres i et internationalt perspektiv med forkus på veje til at opnå og opretholde god adfærd i videnskaberne.......Hvad er videnskabelig uredelighed? Hvordan håndterer man problemet? Hvordan forebygger man det? De tre spørgsmål diskuteres i et internationalt perspektiv med forkus på veje til at opnå og opretholde god adfærd i videnskaberne....

  10. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  11. Det var, som om de havde en slags kærlighed til det, de gjorde

    DEFF Research Database (Denmark)

    Hansen, Finn Thorbjørn

    Dette er en videnskabelig rapport bestilt af Folkehøjskolernes Forening i Danmark (FFD) med det formål at undersøge, den eksistentielle dimension i højskolens uddannelses- og erhvervsvejledning. På baggrund af tre empiriske studier på tre forskellige folkehøjskoler og teoretiske (pædagogisk-filos......-filosofiske) studier omkring begrebet "det eksistentielle" og "filosofisk vejledning" gøres der rede for og diskuteres, hvorledes man kan tænke og praktisere "eksistentiel vejledning" i højskolens uddannelses- og erhvervsvejledning....

  12. Mestringsteorier i sygeplejen

    DEFF Research Database (Denmark)

    Glinsvad, Birte

    2014-01-01

    Kapitlet indledes med refleksioner over begrebet mestring. Dernæst præsenteres tre teoretikere, der på hver deres måde har beskæftiget sig med mestring: Arthur Kleinman, Aaron Antonovsky og Richard S. Lazarus. Teorierne relateres til en case.......Kapitlet indledes med refleksioner over begrebet mestring. Dernæst præsenteres tre teoretikere, der på hver deres måde har beskæftiget sig med mestring: Arthur Kleinman, Aaron Antonovsky og Richard S. Lazarus. Teorierne relateres til en case....

  13. La Diversidad del Islam: Del Desconocimiento al Entendimiento

    Directory of Open Access Journals (Sweden)

    Dolors Bramon

    2003-01-01

    Full Text Available Resumen: A partir de la idea de que judíos, cristianos y musulmanes se diferencian por su fe en un mismo Dios, se exponen las creencias y prácticas del is lam (sus dog mas y los llamados cinco pilares. Así pueden entenderse las principales divergencias que existen en tre los musulmanes y los otros fieles monoteístas. En tre ellas, la que parece insalvable es la de la consideración de la divinidad de Jesús.

  14. God IKT-praksis

    DEFF Research Database (Denmark)

    Wentzer, Helle

    Afhandlingen afdækker tværvidenskabelige problemstillinger for informatik fra et humanistisk perspektiv. 'God IKT-praksis' bidrager med udgangspunkt i sundhedssektoren med tre begreber til konstruktive design- og læreprocesser ved implementering og evaluering af IKT. Begreberne er: ‘E-tekstens po......Afhandlingen afdækker tværvidenskabelige problemstillinger for informatik fra et humanistisk perspektiv. 'God IKT-praksis' bidrager med udgangspunkt i sundhedssektoren med tre begreber til konstruktive design- og læreprocesser ved implementering og evaluering af IKT. Begreberne er: ‘E...

  15. Improvement and amplification of the I modulate CDSM (control sub device modulates) of the system DECADES

    International Nuclear Information System (INIS)

    Turtos Carbonell, Leonor

    1999-01-01

    The present work consists on the improvement and amplification of the module CDSM of the one System DECADES starting from the experience acquired in the use of the same one. It was implemented The calculation for all the Technologies of Reduction of Emissions (TRE) included in the one System for all the levels of foreseen analysis (it plants, chain and Electroenergetic Systems ), a case of test was evaluated with all the TRE and those were validated results obtained with available data in the reference bibliography

  16. Ud at se med Erasmus

    DEFF Research Database (Denmark)

    Frandsen, Pernille

    2009-01-01

    Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus.......Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus....

  17. Être là ou ne pas être là – esquisse de typologie du spectral dans quelques œuvres littéraires occidentales contemporaines

    Directory of Open Access Journals (Sweden)

    Catherine Grall

    2017-06-01

    esthétique plastique (Warburg, Foster, Didi-Hubermann et à des considérations culturalistes et philosophiques (Bhabha, Zizek, Derrida. Ces fictions qui mettent en scène un monde réaliste font éprouver une altérité radicale en son sein même, comme une nécessité à reconnaître : il s’agit d’une nouvelle dimension idéographique de la fiction (selon le mot de Pavel dans La Pensée du roman, où la paradigme actantiel cède au profit de formes pathétiques qui expriment des enjeux collectifs.

  18. Effects of adding food by-products mainly including noodle waste to total mixed ration silage on fermentation quality, feed intake, digestibility, nitrogen utilization and ruminal fermentation in wethers.

    Science.gov (United States)

    Ishida, Kyohei; Yani, Srita; Kitagawa, Masayuki; Oishi, Kazato; Hirooka, Hiroyuki; Kumagai, Hajime

    2012-11-01

    Four wethers were used in a 4 × 4 Latin square design experiment to evaluate the applicability of two types of total mixed ration (TMR) silage with food by-products. Four food by-products (i.e., potato waste, soy sauce cake, soybean curd residue and noodle waste) were obtained and mixed with commercial concentrate (CC) as TMR silage. The two types of TMR silage, T1 and T2, each contained CC, in addition to all by-products for T1 (TRE1), and soy sauce cake and noodle waste for T2 (TRE2) on a dry matter (DM) basis. The silage was well-fermented with low pH values and high lactic acid concentration. As the experimental treatments, T1, T2 and CC (CTL) were fed with a basal diet. The result showed that the digestibility of DM and organic matter (OM) were higher for T1 than for CC (P < 0.05), while crude protein digestibility was not significantly different among T1, T2 and CC. The retained nitrogen was not affected by inclusion of food by-products. Ruminal pH in TRE1 and TRE2 immediately decreased compared to that in CTL. The study suggested that the two types of TMR silage, including food by-products, might be used as a substitute for commercial concentrate. © 2012 The Authors. Animal Science Journal © 2012 Japanese Society of Animal Science.

  19. Single-step generation of gene knockout-rescue system in pluripotent stem cells by promoter insertion with CRISPR/Cas9.

    Science.gov (United States)

    Matsunaga, Taichi; Yamashita, Jun K

    2014-02-07

    Specific gene knockout and rescue experiments are powerful tools in developmental and stem cell biology. Nevertheless, the experiments require multiple steps of molecular manipulation for gene knockout and subsequent rescue procedures. Here we report an efficient and single step strategy to generate gene knockout-rescue system in pluripotent stem cells by promoter insertion with CRISPR/Cas9 genome editing technology. We inserted a tetracycline-regulated inducible gene promoter (tet-OFF/TRE-CMV) upstream of the endogenous promoter region of vascular endothelial growth factor receptor 2 (VEGFR2/Flk1) gene, an essential gene for endothelial cell (EC) differentiation, in mouse embryonic stem cells (ESCs) with homologous recombination. Both homo- and hetero-inserted clones were efficiently obtained through a simple selection with a drug-resistant gene. The insertion of TRE-CMV promoter disrupted endogenous Flk1 expression, resulting in null mutation in homo-inserted clones. When the inserted TRE-CMV promoter was activated with doxycycline (Dox) depletion, Flk1 expression was sufficiently recovered from the downstream genomic Flk1 gene. Whereas EC differentiation was almost completely perturbed in homo-inserted clones, Flk1 rescue with TRE-CMV promoter activation restored EC appearance, indicating that phenotypic changes in EC differentiation can be successfully reproduced with this knockout-rescue system. Thus, this promoter insertion strategy with CRISPR/Cas9 would be a novel attractive method for knockout-rescue experiments. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. A toxicity reduction evaluation for an oily waste treatment plant exhibiting episodic effluent toxicity.

    Science.gov (United States)

    Erten-Unal, M; Gelderloos, A B; Hughes, J S

    1998-07-30

    A Toxicity Reduction Evaluation (TRE) was conducted on the oily wastewater treatment plant (Plant) at a Naval Fuel Depot. The Plant treats ship and ballast wastes, berm water from fuel storage areas and wastes generated in the fuel reclamation plant utilizing physical/chemical treatment processes. In the first period of the project (Period I), the TRE included chemical characterization of the plant wastewaters, monitoring the final effluent for acute toxicity and a thorough evaluation of each treatment process and Plant operating procedures. Toxicity Identification Evaluation (TIE) procedures were performed as part of the overall TRE to characterize and identify possible sources of toxicity. Several difficulties were encountered because the effluent was saline, test organisms were marine species and toxicity was sporadic and unpredictable. The treatability approach utilizing enhancements, improved housekeeping, and operational changes produced substantial reductions in the acute toxicity of the final effluent. In the second period (Period II), additional acute toxicity testing and chemical characterization were performed through the Plant to assess the long-term effects of major unit process improvements for the removal of toxicity. The TIE procedures were also modified for saline wastewaters to focus on suspected class of toxicants such as surfactants. The TRE was successful in reducing acute toxicity of the final effluent through process improvements and operational modifications. The results indicated that the cause of toxicity was most likely due to combination of pollutants (matrix effect) rather than a single pollutant.

  1. Confronting the ’Essence of Decision’: Canada and the Cuban Missile Crisis

    Science.gov (United States)

    2010-11-01

    mesures faisables, voire idéales, étaient en place à l’époque et que le Comité des chefs d’état-major aurait pu y recourir pour accroître les niveaux de...direction militaire et pourquoi ne les ont-ils pas utilisées? Dans la présente étude, on avance que les chefs d’état-major auraient pu accroître les...appointment as a Companion of the Order of Canada for his long service to Canada.45 Some accounts highlight Bryce’s central role in coordinating

  2. Fra selvdannelse til eksistensoplysning

    DEFF Research Database (Denmark)

    Hansen, Finn Thorbjørn

    2002-01-01

    Dette indledningskapitel for KVANs temanummer om børn og modernitet gør rede for modernitetsfænomenet beskrevet gennem henholdsvis Foucaults, Rortys og Schanzs optik og det diskuteres hvordan disse tre forskellige optikker tegner en oplysningsforståelse i dag. Artiklen afsluttes med en perspektiv......Dette indledningskapitel for KVANs temanummer om børn og modernitet gør rede for modernitetsfænomenet beskrevet gennem henholdsvis Foucaults, Rortys og Schanzs optik og det diskuteres hvordan disse tre forskellige optikker tegner en oplysningsforståelse i dag. Artiklen afsluttes med en...

  3. Menneske eller borger

    DEFF Research Database (Denmark)

    Komischke-Konnerup, Leo

    Menneske eller borger er en almenpædagogisk indføring i spørgsmålet om skolens pædagogiske og politiske opgave: Er skolen og dens pædagogiske praksis til for det frie menneske eller den forpligtede borger? Dette pædagogiske grundproblem belyses gennem studiet af tre centrale pædagogiske tænkeres ...... teorier: J.-J. Rousseau, W. von Humboldt og D. Benner. Bogens tre studier er forsynet med studiespørgsmål. Bogen afsluttes med et didaktisk appendix af lektor ved læreruddannelsen N. Leding Olsen....

  4. De Caniba ou Cannibale de Christophe Colomb à Caliban d’Aime Cesaire

    Directory of Open Access Journals (Sweden)

    Ece Yassıtepe Ayyıldız

    2017-12-01

    Full Text Available Le mot « caniba » apparaît dans la littérature dès le début de la colonisation du Nouveau Monde. Christophe Colomb, explorateur du nouveau continent, a appelé des Indiens comme « caniba » qui devient « cannibale » dans les « Essais » de Montaigne. Ce mot a un sens péjoratif qui signifie « mangeurs d’hommes » dans la langue des Indiens. William Shakespeare a écrit une pièce de théâtre intitulée « La Tempête » dans laquelle il a nommé l’un de ses caractères principaux comme Caliban qui est un substantif transformé du mot « Cannibale ». Caliban, le roi d’une île, a déjà perdu son règne et est devenu esclave après l’arrivée de Prospero, duc de Milan, sur l'île de Caliban. La pièce intitulée « La Tempête » écrite en 1611 est la dernière pièce de Shakespeare dont le sujet est la relation maître-esclave entre Caliban et Prospero. Aimé Césaire, aussi, dramaturge martiniquais, a écrit une pièce de théâtre intitulée « Une Tempête » qui est une adaptation pour un « théâtre nègre ». Aimé Césaire qui a écrit cette pièce dans la période postcoloniale et utilise Caliban comme le porte-parole des Noirs opprimés au cours de l’histoire. Dans cette étude, notre but est d'insister sur l’étymologie du mot « caniba » et ses apparitions dans le théâtre shakespearien et césairien et de montrer en analysant le changement du mot caniba, qui a un sens péjoratif dès le départ.

  5. 3D prostate histology image reconstruction: Quantifying the impact of tissue deformation and histology section location

    Directory of Open Access Journals (Sweden)

    Eli Gibson

    2013-01-01

    Full Text Available Background: Guidelines for localizing prostate cancer on imaging are ideally informed by registered post-prostatectomy histology. 3D histology reconstruction methods can support this by reintroducing 3D spatial information lost during histology processing. The need to register small, high-grade foci drives a need for high accuracy. Accurate 3D reconstruction method design is impacted by the answers to the following central questions of this work. (1 How does prostate tissue deform during histology processing? (2 What spatial misalignment of the tissue sections is induced by microtome cutting? (3 How does the choice of reconstruction model affect histology reconstruction accuracy? Materials and Methods: Histology, paraffin block face and magnetic resonance images were acquired for 18 whole mid-gland tissue slices from six prostates. 7-15 homologous landmarks were identified on each image. Tissue deformation due to histology processing was characterized using the target registration error (TRE after landmark-based registration under four deformation models (rigid, similarity, affine and thin-plate-spline [TPS]. The misalignment of histology sections from the front faces of tissue slices was quantified using manually identified landmarks. The impact of reconstruction models on the TRE after landmark-based reconstruction was measured under eight reconstruction models comprising one of four deformation models with and without constraining histology images to the tissue slice front faces. Results: Isotropic scaling improved the mean TRE by 0.8-1.0 mm (all results reported as 95% confidence intervals, while skew or TPS deformation improved the mean TRE by <0.1 mm. The mean misalignment was 1.1-1.9΀ (angle and 0.9-1.3 mm (depth. Using isotropic scaling, the front face constraint raised the mean TRE by 0.6-0.8 mm. Conclusions: For sub-millimeter accuracy, 3D reconstruction models should not constrain histology images to the tissue slice front faces and

  6. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Wei, E-mail: hongwei@tijmu.edu.cn [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Li, Jinru; Wang, Bo [College of Basic Medicine, Tianjin Medical University, 300070 Tianjin (China); Chen, Linfeng [Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, 02115 MA (United States); Niu, Wenyan; Yao, Zhi [Department of Immunology, Tianjin Medical University, 300070 Tianjin (China); Baniahmad, Aria, E-mail: aban@mti.uni-jena.de [Institute for Human Genetics, Jena University Hospital, 07740 Jena (Germany)

    2011-12-02

    Highlights: Black-Right-Pointing-Pointer Corepressor Alien interacts with histone methyltransferase ESET in vivo. Black-Right-Pointing-Pointer Alien/ESET complex is recruited to nTRE of T3-responsive gene by liganded TR{beta}1. Black-Right-Pointing-Pointer ESET-mediated H3K9 methylation is required for liganded TR{beta}1-repressed transcription. Black-Right-Pointing-Pointer ESET is involved in T3-repressed G1/S phase transition and proliferation. -- Abstract: The ligand-bound thyroid hormone receptor (TR) is known to repress via a negative TRE (nTRE) the expression of E2F1, a key transcription factor that controls the G1/S phase transition. Alien has been identified as a novel interacting factor of E2F1 and acts as a corepressor of E2F1. The detailed molecular mechanism by which Alien inhibits E2F1 gene expression remains unclear. Here, we report that the histone H3 lysine 9 (H3K9) methyltransferase (HMT) ESET is an integral component of the corepressor Alien complex and the Alien/ESET complex is recruited to both sites, the E2F1 and the nTRE site of the E2F1 gene while the recruitment to the negative thyroid hormone response element (nTRE) is induced by the ligand-bound TR{beta}1 within the E2F1 gene promoter. We show that, overexpression of ESET promotes, whereas knockdown of ESET releases, the inhibition of TR{beta}1-regulated gene transcription upon T3 stimulation; and H3K9 methylation is required for TR{beta}1-repressed transcription. Furthermore, depletion of ESET impairs thyroid hormone-repressed proliferation as well as the G1/S transition of the cell cycle. Taken together, our data indicate that ESET is involved in TR{beta}1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation.

  7. De-phosphorylation of TRα-1 by p44/42 MAPK inhibition enhances T3-mediated GLUT5 gene expression in the intestinal cell line Caco-2 cells

    International Nuclear Information System (INIS)

    Mochizuki, Kazuki; Sakaguchi, Naomi; Takabe, Satsuki; Goda, Toshinao

    2007-01-01

    Thyroid hormone and p44/42 MAPK inactivation are important in intestinal differentiation. We demonstrated not only that treatment with p44/42 MAPK inhibitor U0126 in intestinal cell line Caco-2 cells reduced the phosphorylation of serine and threonine residues of TRα-1, but also that T 3 and U0126 synergistically induced GLUT5 gene expression. EMSA demonstrated that the binding activity of TRα-1-RXR heterodimer on GLUT5-TRE in nuclear proteins of Caco-2 cells was synergistically enhanced by co-incubation in vitro with T 3 and CIAP, which strongly de-phosphorylates proteins. ChIP and transfection assays revealed that co-treatment of T 3 and U0126 induces TRα-1-RXR binding to GLUT5-TRE on the human GLUT5 enhancer region, and recruitment of the transcriptional complex in cells. These results suggest that inactivation of p44/42 MAPK enhances T 3 -induced GLUT5 gene expression in Caco-2 cells through increasing TRα-1 transactivity and binding activity to the GLUT5-TRE, probably due to de-phosphorylation of TRα-1

  8. Utilisation des mousses et des pâtes syntactiques pour combler les lacunes des poteries archéologiques

    Directory of Open Access Journals (Sweden)

    Viviane Bechoux

    2008-10-01

    Full Text Available Filling potteries missing parts with plaster raises now complex problems during the de-restoration treatments. Ceramics restorers have recurrently questions on the use of plaster in the field of archaeological ceramics restoration. Some researches point to the choice of other filling materials. At the present time other methods can be devised by proposing plaster replacement by a lightened composite material: syntactic foams and pastes.Le comblement des lacunes des poteries à partir du plâtre pose actuellement des problèmes complexes lors des traitements de dérestauration. Les restaurateurs de céramiques s'interrogent de manière récurrente sur l'utilisation du plâtre dans le domaine de la restauration des céramiques archéologiques. Des recherches s'orientent vers le choix d'autres matériaux d'obturation. Actuellement, d'autres méthodes peuvent être mises en place en proposant le remplacement du plâtre par un matériau composite allégé, les mousses et les pâtes syntactiques.

  9. Inducible expression of trehalose synthase in Bacillus licheniformis.

    Science.gov (United States)

    Li, Youran; Gu, Zhenghua; Zhang, Liang; Ding, Zhongyang; Shi, Guiyang

    2017-02-01

    Trehalose synthase (TreS) could transform maltose into trehalose via isomerization. It is a crucial enzyme in the process of trehalose enzymatical transformation. In this study, plasmid-based inducible expression systems were constructed to produce Thermomonospora curvata TreS in B. licheniformis. Xylose operons from B. subtilis, B. licheniformis and B. megaterium were introduced to regulate the expression of the gene encoding TreS. It was functionally expressed, and the BlsTs construct yielded the highest enzyme activity (12.1 U/mL). Furthermore, the effect of different cultural conditions on the inducible expression of BlsTs was investigated, and the optimal condition was as follows: 4% maltodextrin, 0.4% soybean powder, 1% xylose added after 10 h of growth and an induction time of 12 h at 37 °C. As a result, the maximal yield reached 24.7 U/mL. This study contributes to the industrial application of B. licheniformis, a GRAS workhorse for enzyme production. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. L’individu comme problème phénoménologique chez Hannah Arendt et Michel Henry

    Directory of Open Access Journals (Sweden)

    Jan Cerny

    2012-12-01

    Full Text Available Cette étude, dans un premier temps, apporte des preuves à la possibilité d’interpréter la pensée politique de Hannah Arendt comme un projet phénoménologique original dont le but est d’élever l’apparence de la personne au rang de mode unique de l’apparaître. Puis elle présente brièvement la phénoménologie matérielle de Michel Henry dans laquelle le Soi individuel joue un rôle tout aussi central, puisqu’il est la condition de l’apparence de la vie et le fondement de tout apparaître. En conclusion, l’étude esquisse les conséquences d’une telle position privilégiée du sujet individuel pour la conception théorique de la réalité effective de l’apparaître, de même que pour les problèmes pratiques de l’action de l’homme dans le monde.

  11. SU-F-J-88: Comparison of Two Deformable Image Registration Algorithms for CT-To-CT Contour Propagation

    International Nuclear Information System (INIS)

    Gopal, A; Xu, H; Chen, S

    2016-01-01

    Purpose: To compare the contour propagation accuracy of two deformable image registration (DIR) algorithms in the Raystation treatment planning system – the “Hybrid” algorithm based on image intensities and anatomical information; and the “Biomechanical” algorithm based on linear anatomical elasticity and finite element modeling. Methods: Both DIR algorithms were used for CT-to-CT deformation for 20 lung radiation therapy patients that underwent treatment plan revisions. Deformation accuracy was evaluated using landmark tracking to measure the target registration error (TRE) and inverse consistency error (ICE). The deformed contours were also evaluated against physician drawn contours using Dice similarity coefficients (DSC). Contour propagation was qualitatively assessed using a visual quality score assigned by physicians, and a refinement quality score (0 0.9 for lungs, > 0.85 for heart, > 0.8 for liver) and similar qualitative assessments (VQS 0.75 for lungs). When anatomical structures were used to control the deformation, the DSC improved more significantly for the biomechanical DIR compared to the hybrid DIR, while the VQS and RQS improved only for the controlling structures. However, while the inclusion of controlling structures improved the TRE for the hybrid DIR, it increased the TRE for the biomechanical DIR. Conclusion: The hybrid DIR was found to perform slightly better than the biomechanical DIR based on lower TRE while the DSC, VQS, and RQS studies yielded comparable results for both. The use of controlling structures showed considerable improvement in the hybrid DIR results and is recommended for clinical use in contour propagation.

  12. A Teacher Research Experience: Immersion Into the World of Practicing Ocean Scientists

    Science.gov (United States)

    Payne, D. L.

    2006-12-01

    Professional development standards for science teachers encourage opportunities for intellectual professional growth, including participation in scientific research (NRC, 1996). Strategies to encourage the professional growth of teachers of mathematics and science include partnerships with scientists and immersion into the world of scientists and mathematicians (Loucks-Horsley, Love, Stiles, Mundry, & Hewson, 2003). A teacher research experience (TRE) can often offer a sustained relationship with scientists over a prolonged period of time. Research experiences are not a new method of professional development (Dubner, 2000; Fraser-Abder & Leonhardt, 1996; Melear, 1999; Raphael et al., 1999). Scientists serve as role models and "coaches" for teachers a practice which has been shown to dramatically increase the transfer of knowledge, skill and application to the classroom (Joyce & Showers, 2002). This study investigated if and how secondary teachers' beliefs about science, scientific research and science teaching changed as a result of participation in a TRE. Six secondary science teachers participated in a 12 day research cruise. Teachers worked with scientists, the ships' crew and other teachers conducting research and designing lessons for use in the classroom. Surveys were administered pre and post TRE to teachers and their students. Additionally, teachers were interviewed before, during and after the research experience, and following classroom observations before and after the research cruise. Teacher journals and emails, completed during the research cruise, were also analyzed. Results of the study highlight the use of authentic research experiences to retain and renew science teachers, the impact of the teachers' experience on students, and the successes and challenges of implementing a TRE during the academic year.

  13. Multivariate Hawkes process models of the occurrence of regulatory elements

    DEFF Research Database (Denmark)

    Carstensen, L; Sandelin, A; Winther, Ole

    2010-01-01

    distribution of the occurrences of these TREs along the genome. RESULTS: We present a model of TRE occurrences known as the Hawkes process. We illustrate the use of this model by analyzing two different publically available data sets. We are able to model, in detail, how the occurrence of one TRE is affected....... For each of the two data sets we provide two results: first, a qualitative description of the dependencies among the occurrences of the TREs, and second, quantitative results on the favored or avoided distances between the different TREs. CONCLUSIONS: The Hawkes process is a novel way of modeling the joint...

  14. Crescere errando: minori immigrati non accompagnati" (Clara Silva - Giovanna Campani

    Directory of Open Access Journals (Sweden)

    Olivia Salimbeni

    2005-12-01

    Full Text Available La presenza in Italia di minori immigrati non accompagnati è un fenomeno recente e tuttavia in forte crescita. Questo testo raccoglie i risultati di quella che potremmo definire la seconda di tre tappe di una ricerca europea incentrata sullo studio del fenomeno dei minori immigrati non accompagnati, avviata nel 2000 e da poco terminata. L’indagine è stata svolta nel quadro di finanziamento del 'Programma Daphne' della Commissione Europea e ha riguardato nelle prime due fasi tre realtà europee, Italia, Germania e Finlandia e nella terza altre realtà quali il Portogallo, la Spagna, la Francia e la Grecia.

  15. Bibliographie

    OpenAIRE

    2015-01-01

    Abirached (R.), 1992, Le théâtre et le prince : 1981-1991, Paris, Plon. Abirached (R.) dir., 1994, La décentralisation théâtrale, t. III : 1968 : Le tournant, Actes-Sud-Papiers, Cahiers n° 8. Abirached (R.), 1999, « Le théâtre service public, les avatars d’une notion », L’Observatoire, Bulletin de l’Observatoire des politiques culturelles, supplément n° 17, printemps. ADU (Agence de développement et d’urbanisme), 1991, étudiants de Lille 3, Nouvelles villes internationales : profil et planifi...

  16. Synthetic Aperture Processing of Wideband Scattering Measurements Made in the DRDC Atlantic Acoustic Calibration Tank

    Science.gov (United States)

    2008-09-01

    as represented by the Minister of National Defence, 2008 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la...des mines ventouses d’entraînement réelles, sur un disque de un mètre de diamètre qui était suspendu dans le bassin d’étalonnage acoustique de RDDC...Atlantique à l’aide d’une perche rotative. Deux disques ont été examinés : un en aluminium et l’autre en fibre de verre . Ces disques ont été tournés

  17. African-American English i direkt anföring : Etta James självbiografi översatt till svenska – att anpassa översättningen efter en varietet som inte har någon motsvarighet på svenska

    OpenAIRE

    Anteryd, Linn

    2015-01-01

    Detta examensarbete är indelat i tre delar. Examensarbetet består av en översättning av tre kapitel ur Etta James självbiografi Rage to survive: the Etta James story skriven av James och spökförfattaren David Ritz, samt ett kapitel om vilka textspecifika översättningsproblem som uppstod vid översättningen. Den tredje delen består av en djupanalys av hur varieteten African-American English (AAE) översatts i två andra verk, nämligen I know why the caged bird sings av Maya Angelou och The bluest...

  18. Fascinaţia romanticilor germani faţă de Asia de Sud Robert Cowan , The Indo - German identification : reconciling South Asian origins and European destinies, 1765 - 188 5 , ( Camden House, 2010, 225 pagini

    Directory of Open Access Journals (Sweden)

    Silviu PETRE

    2013-01-01

    Full Text Available Cartea lui Robert Cowan spune povestea instrumentalizării Indiei în articularea mitului arian de către diferiţii scriitori de secol XVIII- XIX şi XX. Cartea nu se ocupă de preluarea mitului arian de către cel de - al III-lea Reich, fapt de altfel foarte documentat, în mod serios sau senzaţional dar alocă un spaţiu marginal şi modului cum arianismul a devenit un bun al ultranaţionaliştilor hinduşi de dupăindependenţa din 1947.

  19. Fossiler i Grønland. 2. del

    DEFF Research Database (Denmark)

    Harper, David Alexander Taylor; Lindow, Bent Erik Kramer

    2009-01-01

    Dette er anden og sidste del af POST Greenlands serie om fossiler i Grønland med tre frimærker, der beretter om de mange og spændende fossilfund fra Grønland. Mærkerne fortsætter vores rejse gennem nogle af nøglebegivenhederne i livets historie, smukt illustreret af endnu flere unikke fossiler....... Disse tre fossiler, en plante, et bløddyr og et hvirveldyr, er fra de yngre aflejringer i Grønland med aldre spændende fra for 200 millioner og indtil kun 8.000 år siden....

  20. Print og netaviser i Danmark, USA og Frankrig

    DEFF Research Database (Denmark)

    Ørsten, Mark; Willig, Ida

    2013-01-01

    Denne artikel undersøger forskelle og ligheder mellem print og netaviser i Danmark, USA og Frankrig, både på tværs af platforme og på tværs af de tre analyserede lande. Den komparative analyse sker med udgangspunkt i mediesystemteori, hvor Danmark er placeret i den korporative/demokratiske model,...... vinde indpas på bekostning af de andre modeller. Denne artikels resultater peger dog på, at kommercielle aspekter muligvis har større indflydelse på tværs af alle tre modeller, når det komparative fokus skifter fra print til net....

  1. Kompetenceopbygning i tre succesfulde danske fødevarevirksomheder

    DEFF Research Database (Denmark)

    Jensen, Bjarne; Harmsen, Hanne

    2000-01-01

    that the companies are good at compared to their competitors. These competences are called distinctive competences. 2. In total, the participating five food companies pointed at 11 different distinctive competences of which the competences product development, customer relations and quality management are the three....... Furthermore, in those cases where more than one food company has pointed at a particular competence as a distinctive competence, it is evident that the companies have structured the competence very differently. This also indicates that there is "room" for building up a particular competence in different ways...... and still - or rather therefore - be successful with the competence. 4. The study reveals that competence structures are complex entities that are made up of six different competence elements that are interrelated and interdependent. The six competence elements are 1) activities, 2) management and control...

  2. Être humain, être dans la lune ?

    Directory of Open Access Journals (Sweden)

    Augustin Berque

    2010-09-01

    Full Text Available L’ouvrage commence par une épigraphe de Heidegger : […] ce sont les structures constituant l’existence qu’il s’agit de dégager l’une après l’autre. L’ensemble que forment ces structures réunies, nous l’appelons l’existentialité. Son analytique a le caractère d’une entente non pas existentielle mais existentiale . « […] nicht eines existenziellen, sondern existenzialen Verstehens » (Heidegger, [1927] 1993, p. 12. Il faut en effet savoir, ce que nous ...

  3. Robust methods for automatic image-to-world registration in cone-beam CT interventional guidance

    International Nuclear Information System (INIS)

    Dang, H.; Otake, Y.; Schafer, S.; Stayman, J. W.; Kleinszig, G.; Siewerdsen, J. H.

    2012-01-01

    Purpose: Real-time surgical navigation relies on accurate image-to-world registration to align the coordinate systems of the image and patient. Conventional manual registration can present a workflow bottleneck and is prone to manual error and intraoperator variability. This work reports alternative means of automatic image-to-world registration, each method involving an automatic registration marker (ARM) used in conjunction with C-arm cone-beam CT (CBCT). The first involves a Known-Model registration method in which the ARM is a predefined tool, and the second is a Free-Form method in which the ARM is freely configurable. Methods: Studies were performed using a prototype C-arm for CBCT and a surgical tracking system. A simple ARM was designed with markers comprising a tungsten sphere within infrared reflectors to permit detection of markers in both x-ray projections and by an infrared tracker. The Known-Model method exercised a predefined specification of the ARM in combination with 3D-2D registration to estimate the transformation that yields the optimal match between forward projection of the ARM and the measured projection images. The Free-Form method localizes markers individually in projection data by a robust Hough transform approach extended from previous work, backprojected to 3D image coordinates based on C-arm geometric calibration. Image-domain point sets were transformed to world coordinates by rigid-body point-based registration. The robustness and registration accuracy of each method was tested in comparison to manual registration across a range of body sites (head, thorax, and abdomen) of interest in CBCT-guided surgery, including cases with interventional tools in the radiographic scene. Results: The automatic methods exhibited similar target registration error (TRE) and were comparable or superior to manual registration for placement of the ARM within ∼200 mm of C-arm isocenter. Marker localization in projection data was robust across all

  4. Influence of freeze-drying and γ-irradiation in preclinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using d-(+)-trehalose and polyethylene glycol.

    Science.gov (United States)

    Ramos Yacasi, Gladys Rosario; García López, María Luisa; Espina García, Marta; Parra Coca, Alexander; Calpena Campmany, Ana Cristina

    This study investigated the suspension of poly(ε-caprolactone) nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs) in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.5%) and submitted individually for freeze-drying and γ-irradiation with polyethylene glycol 3350 (PEG3350) and d-(+)-trehalose (TRE). Both formulations satisfied criteria according to all physicochemical parameters required for ocular pharmaceuticals. The FB-PεCL-NP formulations showed non-Newtonian behavior and sustained drug release. Ex vivo permeation analysis using isolated ocular pig tissues suggested that the presence of PEG3350 results in a reduction of FB transcorneal permeation. Moreover, TRE improved the penetration of FB across the cornea, especially after γ-irradiation. In addition, both formulations did not show a significant affinity in increasing FB transscleral permeation. Both formulations were classified as nonirritating, safe products for ophthalmic administration according to hen's egg test-chorioallantoic membrane and Draize eye test. Furthermore, an in vivo anti-inflammatory efficacy test showed that irradiated FB-PεCL-NPs prepared with PEG3350 (IR-NPsPEG) have longer anti-inflammatory effects than those presented with irradiated FB-PεCL-NPs prepared with TRE (IR-NPsTRE). IR-NPsPEG showed a suitable physical stability after an aqueous reconstitution over >30 days. This study concludes that both formulations meet the Goldman's criteria and demonstrate how irradiated nanoparticles, with innovative permeation characteristics, could be used as a feasible alternative to a flurbiprofen solution for ocular application in clinical trials.

  5. Trehalose metabolism genes render rice white tip nematode Aphelenchoides besseyi (Nematoda: Aphelenchoididae) resistant to an anaerobic environment

    Science.gov (United States)

    Chen, Qiaoli; Zhang, Ruizhi; Ling, Yaming

    2018-01-01

    ABSTRACT After experiencing anaerobic environments, Aphelenchoides besseyi will enter a state of suspended animation known as anoxybiosis, during which it may use trehalose as an energy supply to survive. To explore the function of trehalose metabolism, two trehalose-6-phosphate synthase (TPS) genes (Ab-tps1 and Ab-tps2) encoding enzymes catalysing trehalose synthesis, and three trehalase (TRE) genes (Ab-ntre1, Ab-ntre2 and Ab-atre) encoding enzymes catalysing the hydrolysis of trehalose, were identified and investigated. Ab-tps1 and Ab-tps2 were active during certain periods of anoxybiosis for A. besseyi, and Ab-tps2, Ab-ntre1, Ab-ntre2 and Ab-atre were active during certain periods of recovery. The results of RNA interference experiments suggested that TRE genes regulated each other and both TPS genes, while a single TPS gene only regulated the other TPS gene. However, two TPS genes together could regulate TRE genes, which indicated a feedback mechanism between these genes. All these genes also positively regulated the survival and resumption of active metabolism of the nematode. Genes functioning at re-aeration have a greater impact on nematode survival, suggesting that these genes could play roles in anoxybiosis regulation, but may function within restricted time frames. Changes in trehalose levels matched changes in TRE activity during the anoxybiosis–re-aeration process, suggesting that trehalose may act as an energy supply source. The observation of up-regulation of TPS genes during anoxybiosis suggested a possible signal role of trehalose. Trehalose metabolism genes could also work together to control trehalose levels at a certain level when the nematode is under anaerobic conditions. PMID:29158222

  6. The acute effects of a caffeine-containing supplement on bench press strength and time to running exhaustion.

    Science.gov (United States)

    Beck, Travis W; Housh, Terry J; Malek, Moh H; Mielke, Michelle; Hendrix, Russell

    2008-09-01

    The purpose of the present study was to examine the acute effects of a caffeine-containing supplement (SUPP) on one-repetition maximum (1-RM) bench press strength and time to running exhaustion (TRE) at a velocity that corresponded to 85% of the peak oxygen uptake ([latin capital V with dot above]O2peak). The study used a double-blinded, placebo-controlled, crossover design. Thirty-one men (mean +/- SD age = 23.0 +/- 2.6 years) were randomly assigned to take either the SUPP or placebo (PLAC) first. The SUPP contained 201 mg of caffeine, and the PLAC was microcrystalline cellulose. All subjects were tested for 1-RM bench press strength and TRE at 45 minutes after taking either the SUPP or PLAC. After 1 week of rest, the subjects returned to the laboratory and ingested the opposite substance (SUPP or PLAC) from what was taken during the previous visit. The 1-RM bench press and TRE tests were then performed in the same manner as before. The results indicated that the SUPP had no effect on 1-RM bench press strength or TRE at 85% [latin capital V with dot above]O2peak. It is possible that the acute effects of caffeine are affected by differences in training status and/or the relative intensity of the exercise task. Future studies should examine these issues, in addition to testing the acute effects of various caffeine doses on performance during maximal strength, power, and aerobic activities. These findings do not, however, support the use of caffeine as an ergogenic aid in untrained to moderately trained individuals.

  7. Viewing ISS Data in Real Time via the Internet

    Science.gov (United States)

    Myers, Gerry; Chamberlain, Jim

    2004-01-01

    EZStream is a computer program that enables authorized users at diverse terrestrial locations to view, in real time, data generated by scientific payloads aboard the International Space Station (ISS). The only computation/communication resource needed for use of EZStream is a computer equipped with standard Web-browser software and a connection to the Internet. EZStream runs in conjunction with the TReK software, described in a prior NASA Tech Briefs article, that coordinates multiple streams of data for the ground communication system of the ISS. EZStream includes server components that interact with TReK within the ISS ground communication system and client components that reside in the users' remote computers. Once an authorized client has logged in, a server component of EZStream pulls the requested data from a TReK application-program interface and sends the data to the client. Future EZStream enhancements will include (1) extensions that enable the server to receive and process arbitrary data streams on its own and (2) a Web-based graphical-user-interface-building subprogram that enables a client who lacks programming expertise to create customized display Web pages.

  8. The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.

    Science.gov (United States)

    Diccianni, M B; Imagawa, M; Muramatsu, M

    1992-10-11

    Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE). GPEI is active in AP1-lacking F9 cells as well in AP1-containing HeLa cells. Despite GPEI's similarity to a TRE, c-jun co-transfection has only a minimal effect on transactivation. Antisense c-jun and c-fos co-transfection experiments further demonstrate the lack of a role for AP1 in GPEI mediated trans-activation in F9 cells, although endogenously present AP1 can influence GPEI in HeLa cells. Co-transfection of delta fosB with c-jun, which forms an inactive c-Jun/delta FosB heterodimer that binds TRE sequences, inhibits GPEI-mediated transcription in AP1-lacking F9 cells as well as AP1-containing HeLa cells. These data suggest novel factor(s) other than AP1 are influencing GPEI. Binding studies reveal multiple nucleoproteins bind to GPEI. These factors are likely responsible for the high level of GPEI-mediated transcription observed in the absence of AP1 and during hepatocarcinogenesis.

  9. Metabolic, thermoregulatory, and perceptual responses during exercise after lower vs. whole body precooling.

    Science.gov (United States)

    White, Andrea T; Davis, Scott L; Wilson, Thad E

    2003-03-01

    The purpose of this investigation was to compare the thermoregulatory, metabolic, and perceptual effects of lower body (LBI) and whole body (WBI) immersion precooling techniques during submaximal exercise. Eleven healthy men completed two 30-min cycling bouts at 60% of maximal O(2) uptake preceded by immersion to the suprailiac crest (LBI) or clavicle (WBI) in 20 degrees C water. WBI produced significantly lower rectal temperature (T(re)) during minutes 24-30 of immersion and lower T(re), mean skin temperature, and mean body temperature for the first 24, 14, and 16 min of exercise, respectively. Body heat storage rates differed significantly for LBI and WBI during immersion and exercise, although no net differences were observed between conditions. For WBI, metabolic heat production and heart rate were significantly higher during immersion but not during exercise. Thermal sensation was significantly lower (felt colder) and thermal discomfort was significantly higher (less comfortable) for WBI during immersion and exercise. In conclusion, WBI and LBI attenuated T(re) increases during submaximal exercise and produced similar net heat storage over the protocol. LBI minimized metabolic increases and negative perceptual effects associated with WBI.

  10. Políticas para la Diversidad: Hospitalidad contra Extranjería

    Directory of Open Access Journals (Sweden)

    Vicent Martínez Guzmán

    2003-01-01

    Full Text Available En este trabajo tomaremos como punto de partida las “razones” que podríamos tener para no ser solidarios con los “de fuera”, con los que tienen culturas “diferentes” analizando argumento de autores como Hun ting ton y Sartori. En segundo lugar, analizaremos las tensiones en tre cultura como característica de los seres humanos y la diversidad de culturas, la aparición de la noción de extraño y extranjero, el miedo a la diferencia y, en cualquier caso, la sólida relación que se manifiesta en tre los seres humanos incluso cuando nos consideramos extraños. Defenderemos que la relación en tre los seres humanos será violenta, cuando rompa esos vínculos sólidos que constituyen la solidaridad originaria de nuestras relaciones. Finalmente recapitularemos para dar indicadores de solidaridad basados en el derecho a la hospitalidad como constitutivo de la capacidad humana de ser mo rales. La tesis será que somos inmorales si no somos hospitalarios, de ahí que necesitemos políticas para la diversidad.

  11. Théâtre de masques : allégories et déguisements sur la scène comique française des XVe et XVIe siècles.

    Directory of Open Access Journals (Sweden)

    Estelle Doudet

    2008-08-01

    Full Text Available Résumé : Sur la scène comique française des XVe et XVIe siècles abondent masques et déguisements. Tous les acteurs n’en sont pas pourtant revêtus et le sens du costume change selon l’identité du personnage, notamment dans le conflit qui, dans les sotties ou les moralités, opposent Sots et allégories. Le port du masque désigne le Sot et sa parole dénonciatrice : le « faux visage » est, paradoxalement, gage de liberté. Mais lorsque les allégories se déguisent, c’est le fonctionnement de la figure qui est mis en jeu : celle dont l’apparence était l’essence ne peut normalement porter le masque. Les divers types de relations entre l’allégorie et le déguisement créent sur scène une confusion comique autant qu’inquiétante, qui est souvent le moteur de l’action. Les relations au masque des divers personnages de théâtre sont une voie d’analyse pour mieux comprendre une époque majeure de la réflexion sur la représentation et sur les tensions entre apparence et essence.Abstract : Masks in Drama : Allegory and Costume on the French Comic Stage (15th-16th c.. In French comic theatre of the 15th and 16th centuries, masks are commonplace. However, they are worn only by specific figures, and dress changes its meaning from one character to another, especially in the conflict between Fools and allegories in morality plays or sotties. Wearing a mask marks out the Fool and his provocative speech : paradoxically, a ‘false face’ means freedom of expression. But when allegories put on disguises, the very trope of allegory is threatened : its essence lies in appearance, and therefore precludes the use of masks. The different ways in which allegory can be ‘disguised’ on stage provoke comic and often disturbing confusions, which often drive the action. The links between mask and character provide an important approach to the problem of representation in a period which saw considerable reflection on this

  12. Fra konfliktkultur til udvikling i fællesskab - social capital i danske slagterier

    DEFF Research Database (Denmark)

    Hasle, Peter; Møller, Niels

    2005-01-01

    En undersøgelse af tre slagterier som har væsentligt lavere sygefravær, lave personaleomsætning og færre strejker en gennemsnitligt for branchen. Resultaterne viser at ledelse og medarbejdere har formået at opbygge social capital med vægt på tillid, gensidig respekt og anerkendelse.......En undersøgelse af tre slagterier som har væsentligt lavere sygefravær, lave personaleomsætning og færre strejker en gennemsnitligt for branchen. Resultaterne viser at ledelse og medarbejdere har formået at opbygge social capital med vægt på tillid, gensidig respekt og anerkendelse....

  13. Osigurateljev subrogacijski zahtjev prema prijevozniku : tumačenje Čl. III 6A Haško-Visbyjskih pravila : [prikaz presude

    Directory of Open Access Journals (Sweden)

    Vesna Skorupan

    2003-12-01

    Full Text Available Osigurateljev subrogacijski zahtjev prema prijevozniku nije zahtjev za naknadu prema trećoj osobi u smislu čl. III 6A Haško-Visbyjkih pravila. Prijevoznik je tužena strana u sporu s pošiljateljem stvari i činjenica da (subrogacijom osiguratelj zauzima mjesto pošiljatelja ne stavlja prijevoznika u poziciju treće osobe. Položaj prijevoznika se ne mijenja ako pravo osobe koja je s njim sklopila ugovor bude prenijeto na temelju subrogacije na osiguratelja. Zbog toga se i na osiguratelja odnose rokovi zastare koji se primjenjuju prema osiguraniku za tražbine prema prijevozniku.

  14. Sådan bruger du Big Data i din virksomhed

    DEFF Research Database (Denmark)

    Ritter, Thomas; Merolli Poulsen, Christina

    2015-01-01

    Tidligere var der plads til to-tre ligeværdige konkurrenter i en branche. Ikke længere. I fremtiden vil de virksomeder, der formår at høste og bruge Big Data i deres forretning, rydde bordet og sætte sig tungt på alle brancher, skriver to eksperter fra CBS......Tidligere var der plads til to-tre ligeværdige konkurrenter i en branche. Ikke længere. I fremtiden vil de virksomeder, der formår at høste og bruge Big Data i deres forretning, rydde bordet og sætte sig tungt på alle brancher, skriver to eksperter fra CBS...

  15. La Fortification de Troyes en Champagne. Un grand chantier urbain Fin XVe–première moitié du XVIe siècle

    Directory of Open Access Journals (Sweden)

    Brice Collet

    2011-05-01

    Full Text Available Composition du JuryMonsieur Patrick Boucheron, maître de conférence à l’Université de Paris I,Madame Odette Chapelot, maître de conférence à l’ÉHESS,Monsieur Jean Chapelot, directeur de recherche au CNRS (directeur de la thèse,Monsieur Nicolas Faucherre, professeur à l’Université de Nantes,Monsieur Etienne Hamon, professeur à l’Université de Picardie–Jules Verne,Monsieur Pierre Monnet, directeur d’études à l’ÉHESS.Thèse soutenue le 16 décembre 2010RésuméIl ne reste actuellement plus rien ou ...

  16. R.H. MARIJNISSEN, The Masters' and the Forgers' Secrets

    Directory of Open Access Journals (Sweden)

    Muriel Verbeeck-Boutin

    2010-04-01

    Full Text Available Ponctuant une bibliographie impressionnante, variée et traduite en de multiples langues le dernier opus de Rogier-Hendrick Marijnissen est consacré aux Secrets des Maîtres de la peinture flamande et de leurs faussaires. La voie privilégiée pour connaître et reconnaître les uns et les autres demeure la radiographie, clairement désignée dans le sous-titre comme méthode d’authentification.L’auteur a évoqué à plusieurs reprises la révélation qu’a constitué pour lui, au début de sa carrière, l’ouv...

  17. Cours de magnétisme en sept leçons augmenté du rapport sur les expériences magnétiques faites par la commission de l'Académie Royale de Médecine en 1831

    CERN Document Server

    du Potet, Baron

    2015-01-01

    Extrait : ""Pénétré des bienfaits qui doivent résulter pour le genre humain de la découverte du magnétisme animal, je me suis décidé à venir vous en entretenir. Ce n'est pas sans quelque crainte toutefois, car les phénomènes magnétiques que j'ai à vous faire connaître sont si étonnants qu'ils pourront souvent vous paraître exagérés : mais plus ils vous paraîtront extraordinaires et plus ils mériteront de fixer votre attention, s'ils sont vrais.""

  18. International Markedsføring på World Wide Web

    DEFF Research Database (Denmark)

    Rask, Morten; Buch, Niels Jakob

    1999-01-01

    Denne artikel tager udgangspunkt i en gruppe af danske virksomheders anvendelse af World Wide Web til international markedsføring i en periode fra 1996 til 1998. Der identificeres tre interaktionstyper for virksomhedernes profil på Web, nemlig Brochuren, Håndbogen og Handelspladsen. Der reflekteres...... over de krav de enkelte interaktionstyper i forhold til automatisering, formalisering, integration og evaluering kunne kræve. Konklusionen bliver, at de tre interaktionstyper afspejler de udfordringer og muligheder, der er i anvendelsen af Web til markedsføring primært i et internationalt perspektiv......, men kan også bruges som input til nationale Web markedsføringsaktiviteter....

  19. GPS Based Tracking of Mobile Objects

    DEFF Research Database (Denmark)

    Jensen, Christian Søndergaard; Torp, Kristian

    2006-01-01

    Denne artikel beskriver hvorledes man med eksisterende teknologi, herunder Global Position System og General Packet Radio Service, effektivt kan tracke mobile objekter som f.eks. køretøjer med en garanteret nøjagtighed. Først beskrives den teknologiske platform. Herefter beskrives tre forskellige...... teknikker til at tracke mobile objekter. Teknikkerne bliver gradvis mere avancerede. De tre teknikker evalueres, og omkostningen for at tracke et mobilt objekt med en nøjagtighed på cirka 150 meter estimeres til mindre end 1 kr. pr. døgn baseret på priser fra et forsøg udført i 2004. Udgivelsesdato...

  20. Estudio con tomografía de resistividad eléctrica del efecto del tráfico de maquinaria en un suelo agrícola

    OpenAIRE

    Garcia-Tomillo, Aitor; Figueiredo, Tomás de; Dafonte, J.; Almeida, Arlindo; Paz-González, A.

    2015-01-01

    La compactación es un grave problema cuya incidencia aumenta ya que es difícil de localizar y revertir al tratarse de un fenómeno sub-superficial. La tomografía de resistividad eléctrica (TRE) es un método geofísico no invasivo que se puede usar para identificación de áreas compactadas, espesor de horizontes y clasificación de propiedades físicas del suelo. Este trabajo estudia la relación entre la resistividad eléctrica del suelo y la compactación del mismo. Los datos de TRE se tomaron en un...

  1. "Shakespeare Revisited" : Théâtre et métathéâtre dans les comédies de Thomas Kilroy

    OpenAIRE

    Logez-Carpentier, Godeleine

    2017-01-01

    L'œuvre de Kilroy, qui se démarque nettement de la traditon théâtrale réaliste irlandaise longtemps représentée par l'Abbey Theatre, frappe avant tout par sa modernité et son originalité scénique. Si les thèmes de ses pièces restent les mêmes que ceux abordés par les dramaturges de l'Abbaye, leur traitement est cependant radicalement différent, intégrant les bouleversements sociaux, économiques, culturels et spirituels qui caractérisent l'Irlande de la seconde moitié du XXème siècle. A une ap...

  2. Effects of thermal underwear on thermal and subjective responses in winter.

    Science.gov (United States)

    Choi, Jeong-Wha; Lee, Joo-Young; Kim, So-Young

    2003-01-01

    This study was conducted to obtain basic data in improving the health of Koreans, saving energy and protecting environments. This study investigated the effects of wearing thermal underwear for keeping warm in the office in winter where temperature is not as low as affecting work efficiency, on thermoregulatory responses and subjective sensations. In order to create an environment where every subject feels the same thermal sensation, two experimental conditions were selected through preliminary experiments: wearing thermal underwear in 18 degrees C air (18-condition) and not wearing thermal underwear in 23 degrees C air (23-condition). Six healthy male students participated in this study as experiment subjects. Measurement items included rectal temperature (T(re)), skin temperature (T(sk)), clothing microclimate temperature (T(cm)), thermal sensation and thermal comfort. The results are as follows: (1) T(re) of all subjects was maintained constant at 37.1 degrees C under both conditions, indicating no significant differences. (2) (T)(sk) under the 18-condition and the 23-condition were 32.9 degrees C and 33.7 degrees C, respectively, indicating a significant level of difference (pcomfortable under both conditions. It was found (T)(sk) decreased due to a drop in the skin temperature of hands and feet, and the subjects felt cooler wearing only one layer of normal thermal underwear at 18 degrees C. Yet, the thermal comfort level, T(re) and T(cm) of chest part under the 18-condition were the same as those under the 23-condition. These results show that the same level of comfort, T(re) and T(cm) can be maintained as that of an environment about 5 degrees C higher in the office in winter, by wearing one layer of thermal underwear. In this regard, this study suggests that lowering indoor temperature by wearing thermal underwear in winter can contribute to saving energy and improving health.

  3. Development and application of pulmonary structure-function registration methods: towards pulmonary image-guidance tools for improved airway targeted therapies and outcomes

    Science.gov (United States)

    Guo, Fumin; Pike, Damien; Svenningsen, Sarah; Coxson, Harvey O.; Drozd, John J.; Yuan, Jing; Fenster, Aaron; Parraga, Grace

    2014-03-01

    Objectives: We aimed to develop a way to rapidly generate multi-modality (MRI-CT) pulmonary imaging structurefunction maps using novel non-rigid image registration methods. This objective is part of our overarching goal to provide an image processing pipeline to generate pulmonary structure-function maps and guide airway-targeted therapies. Methods: Anatomical 1H and functional 3He MRI were acquired in 5 healthy asymptomatic ex-smokers and 7 ex-smokers with chronic obstructive pulmonary disease (COPD) at inspiration breath-hold. Thoracic CT was performed within ten minutes of MRI using the same breath-hold volume. Landmark-based affine registration methods previously validated for imaging of COPD, was based on corresponding fiducial markers located in both CT and 1H MRI coronal slices and compared with shape-based CT-MRI non-rigid registration. Shape-based CT-MRI registration was developed by first identifying the shapes of the lung cavities manually, and then registering the two shapes using affine and thin-plate spline algorithms. We compared registration accuracy using the fiducial localization error (FLE) and target registration error (TRE). Results: For landmark-based registration, the TRE was 8.4±5.3 mm for whole lung and 7.8±4.6 mm for the R and L lungs registered independently (p=0.4). For shape-based registration, the TRE was 8.0±4.6 mm for whole lung as compared to 6.9±4.4 mm for the R and L lung registered independently and this difference was significant (p=0.01). The difference for shape-based (6.9±4.4 mm) and landmark-based R and L lung registration (7.8±4.6 mm) was also significant (p=.04) Conclusion: Shape-based registration TRE was significantly improved compared to landmark-based registration when considering L and R lungs independently.

  4. Obese type 2 diabetics have a blunted hypotensive response to acute hyperthermia therapy that does not affect the perception of thermal stress or physiological strain compared to healthy adults.

    Science.gov (United States)

    Rivas, Eric; Newmire, Dan E; Ben-Ezra, Vic

    2016-10-15

    The objective of this study was to test the hypothesis that a hyperthermia-hypotensive challenge via whole body hot water immersion would alter the perception of hyperthermia and physiological strain in obese type 2 diabetics (T2DM) compared to healthy non-obese (HC) individuals. Additionally, we hypothesize that the mechanisms would be attributed to impaired blood pressure adjustments and afferent signals (via changes in internal and mean skin temperatures). In random order, eleven obese T2DM (50±12y, 45±7% fat mass, 7.5±1.8% HbA1c) and nine similar aged (41±14y, P>0.05) HC non-obese (33±8% fat mass, Pperception of thermal sensation (TS, scale range: 1-13), calculated physiological strain (PSI), internal (Tre, rectal) and mean skin (Tsk) temperatures, heart rate (HR) and blood pressures (BP) were the primary dependent variables. Hyperthermia similarly increased Tre by 1.4±0.4°C, Tsk by 6.5±0.8°C and HR by 34±8bpm in both groups (P>0.5). Hyperthermia reduced diastolic BP (27% in T2DM and 33% in HC, Pdifferent between groups. Pearson product correlation reported strong correlations (r=0.69-0.89) with Tre and Tsk with TS in both populations. The linear stepwise regression analysis revealed similar relative contributions for Tre (~60%) and Tsk (~40%) on TS for both groups. These data indicate that obese T2DM with moderate metabolic control have an attenuated hyperthermia-hypotensive response that does not affect TS and PSI. This also may suggest behavioral thermoregulation is intact in this study group. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    International Nuclear Information System (INIS)

    Michael, Bindhu; Nair, Amrithraj M.; Datta, Antara; Hiraragi, Hajime; Ratner, Lee; Lairmore, Michael D.

    2006-01-01

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13 II and p30 II , which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30 II , a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30 II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30 II , a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30 II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30 II -dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30 II -mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30 II -mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30 II -mediated LTR repression. Collectively, our data indicate that HTLV-1 p30 II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  6. Le discours scientifique sur la scène britannique : lecture croisée d’On Ego de Mick Gordon et A Disappearing Number de Simon McBurney

    OpenAIRE

    campos , liliane

    2009-01-01

    International audience; Simon McBurney et Mick Gordon ont tous deux cherché à présenter la rencontre du théâtre et des sciences comme le résultat d’affinités évidentes. Gordon, qui a créé ce qu’il appelle des « essais théâtraux » en collaboration avec le neurologue Paul Broks, parle d’un « langage commun » à la neurologie et au théâtre, qui nourrit l'expérience de pensée théâtralisée qu'est le spectacle On Ego. McBurney, qui s’est inspiré de la neurologie et des mathématiques, insiste égaleme...

  7. Vejbygning i områder med permafrost

    DEFF Research Database (Denmark)

    Jørgensen, Anders Stuhr

    2009-01-01

    Siden begyndelsen af 1990’erne er der registreret en markant stigning i den årlige middeltemperatur i Nunavik, Québec Canada. Dette har ført til en reduktion i udbredelsen af permafrost, hvilket truer stabiliteten af lufthavne og veje i området. I sommeren 2007 blev en teststrækning opført i...... Tasiujaq Lufthavn for at studere effekten af tre forskellige metoder, som skal være med til at reducere optøningen af permafrost under landingsbanen. De tre metoder, som er blevet undersøgt, er konvektionskøling (air convection embankment), varmeudtrækning (heat drain) samt et forsøg med ændring af...

  8. Target Registration Error minimization involving deformable organs using elastic body splines and Particle Swarm Optimization approach.

    Science.gov (United States)

    Spinczyk, Dominik; Fabian, Sylwester

    2017-12-01

    In minimally invasive surgery one of the main challenges is the precise location of the target during the intervention. The aim of the study is to present usability of elastic body splines (EBS) to minimize TRE error. The method to find the desired EBS parameters values is presented with usage of Particle Swarm optimization approach. This ability of TRE minimization has been achieved for the respiratory phases corresponding to minimum FRE for abdominal (especially liver) surgery. The proposed methodology was verified during experiments conducted on 21 patients diagnosed with liver tumors. This method has been developed to perform operations in real-time on a standard workstation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Dokumentationsprojektet: Kommunernes omstilling til øget inklusion pr. marts 2014

    DEFF Research Database (Denmark)

    Dyssegaard, Camilla Brørup; Baviskar, Siddhartha; Lausten, Mette

    Denne rapport udgør en redegørelse for status på inklusionsprocessen i tolv danske kommuner pr. marts 2014. Den samlede undersøgelse, der går under navnet "Dokumentationsprojektet", løber i tre år og blev givet til et konsortium bestående af Aarhus Universitet og SFI den 16. januar 2013.......Denne rapport udgør en redegørelse for status på inklusionsprocessen i tolv danske kommuner pr. marts 2014. Den samlede undersøgelse, der går under navnet "Dokumentationsprojektet", løber i tre år og blev givet til et konsortium bestående af Aarhus Universitet og SFI den 16. januar 2013....

  10. Max Weber: posición política, posición teórica y relación con el marxismo en la primera etapa de su producción

    Directory of Open Access Journals (Sweden)

    María Celia Duek

    2009-01-01

    Full Text Available Max Weber redactó sus primeros trabajos en tre 1889 y 1898. Si bien las obras más conocidas del sociólogo alemán fueron escritas en tre 1903 y 1920, es en la producción de la primera etapa en donde ponemos la atención en este artículo. Particularmente nos interesa responder a la siguiente interrogante: ¿cuál fue la relación teórica de Weber con Marx o con el materialismo histórico en dicha fase de su carrera y cómo se vincula esto con las posiciones políticas de ambos clásicos?.

  11. Human thermoregulatory function during exercise and immersion after 35 days of horizontal bed-rest and recovery.

    Science.gov (United States)

    Mekjavic, Igor B; Golja, Petra; Tipton, Michael J; Eiken, Ola

    2005-10-01

    The present study evaluated the effect of 35 days of experimental horizontal bed-rest on exercise and immersion thermoregulatory function. Fifteen healthy male volunteers were assigned to either a Control (n = 5) or Bed-rest (n = 10) group. Thermoregulatory function was evaluated during a 30-min bout of submaximal exercise on a cycle ergometer, followed immediately by a 100-min immersion in 28 degrees C water. For the Bed-rest group, exercise and immersion thermoregulatory responses observed post-bed-rest were compared with those after a 5 week supervised active recovery period. In both trials, the absolute work load during the exercise portion of the test was identical. During the exercise and immersion, we recorded skin temperature, rectal temperature, the difference in temperature between the forearm and third digit of the right hand (DeltaT(forearm-fingertip))--an index of skin blood flow, sweating rate from the forehead, oxygen uptake and heart rate at minute intervals. Subjects provided ratings of temperature perception and thermal comfort at 5-min intervals. Exercise thermoregulatory responses after bed-rest and recovery were similar. Subjective ratings of temperature perception and thermal comfort during immersion indicated that subjects perceived similar combinations of Tsk and Tre to be warmer and thermally less uncomfortable after bed-rest. The average (SD) exercise-induced increase in Tre relative to resting values was not significantly different between the Post-bed-rest (0.4 (0.2) degrees C) and Recovery (0.5 (0.2) degrees C) trials. During the post-exercise immersion, the decrease in Tre, relative to resting values, was significantly (P forearm-fingertip) was 5.2 (0.9) degrees C and 5.8 (1.0) degrees C at the end of the post-bed-rest and recovery immersions, respectively. The gain of the shivering response (increase in VO(2) relative to the decrease in Tre; VO(2)/Tre) was 1.19 l min(-1) degrees C(-1) in the Recovery trial, and was significantly

  12. PET-MR image fusion in soft tissue sarcoma: accuracy, reliability and practicality of interactive point-based and automated mutual information techniques

    International Nuclear Information System (INIS)

    Somer, Edward J.R.; Marsden, Paul K.; Benatar, Nigel A.; O'Doherty, Michael J.; Goodey, Joanne; Smith, Michael A.

    2003-01-01

    The fusion of functional positron emission tomography (PET) data with anatomical magnetic resonance (MR) or computed tomography images, using a variety of interactive and automated techniques, is becoming commonplace, with the technique of choice dependent on the specific application. The case of PET-MR image fusion in soft tissue is complicated by a lack of conspicuous anatomical features and deviation from the rigid-body model. Here we compare a point-based external marker technique with an automated mutual information algorithm and discuss the practicality, reliability and accuracy of each when applied to the study of soft tissue sarcoma. Ten subjects with suspected sarcoma in the knee, thigh, groin, flank or back underwent MR and PET scanning after the attachment of nine external fiducial markers. In the assessment of the point-based technique, three error measures were considered: fiducial localisation error (FLE), fiducial registration error (FRE) and target registration error (TRE). FLE, which represents the accuracy with which the fiducial points can be located, is related to the FRE minimised by the registration algorithm. The registration accuracy is best characterised by the TRE, which is the distance between corresponding points in each image space after registration. In the absence of salient features within the target volume, the TRE can be measured at fiducials excluded from the registration process. To assess the mutual information technique, PET data, acquired after physically removing the markers, were reconstructed in a variety of ways and registered with MR. Having applied the transform suggested by the algorithm to the PET scan acquired before the markers were removed, the residual distance between PET and MR marker-pairs could be measured. The manual point-based technique yielded the best results (RMS TRE =8.3 mm, max =22.4 mm, min =1.7 mm), performing better than the automated algorithm (RMS TRE =20.0 mm, max =30.5 mm, min =7.7 mm) when

  13. Afsluttende kommentar til Jens Ravnkildes tre artikler om retskildebegrebet

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.; Olsen, Henrik Palmer

    2014-01-01

    I dette andet svar til Dr. Jur. Jens Ravnkildes fortsatte forsvar for sit tidligere fremsatte forslag til et retskildebegreb klargør og udbygger lektor Jakob v. H. Holtermann og professor Henrik Palmer Olsen deres kritik yderligere. I den forbindelse afviser de også Ravnkildes ganske sensationell...... påstand om, at Ross blot fem år før sin død i 1979 helt skulle have forladt sit livsværk og opgivet sin karakteristiske version af retsrealismen til fordel for traditionel kelseniansk retspositivisme...

  14. 2018 bliver afgørende for tre danske erhvervsikoner

    DEFF Research Database (Denmark)

    Ørholst, Henrik

    2018-01-01

    Klumme. LEGO, A.P. Møller og Novo Nordisk står alle overfor vigtige strategiske beslutninger i det nye år. Det vil sætte virksomhedernes topchefer på alvorlige prøver, og allerede nu tegner der sig et billede af, hvem der har de bedste kort på hånden....

  15. La conception de l’Étre chez Mélissus

    Directory of Open Access Journals (Sweden)

    Bohdan Wiśniewski

    1985-06-01

    Full Text Available The author tries to demonstrate that the abstract world and the sensible one are independent one from the other in Melissus. The world of physical phaenomena does not arise from the abstract Being according to Melissus, contrary to the opinion held by other philosophers, specially by Parmenides. Melissus' opinion is the first step to deny the abstract Being postulated afterwards by the Sophists.

  16. Tre ipotesi di pedonalizzazione facilitata tra Posillipo e Marechiaro

    Directory of Open Access Journals (Sweden)

    Aldo Capasso

    2010-10-01

    Full Text Available Several publications on pedestrian ways in Naples considered as a tourist attractions, have been published recently. They are based on research works carried out by Naples University scholars. Several Projects taking into account the specific environment of Borgo Marino have been submitted in order to facilitate the connection between Posillipo and Marechiaro area which is besieged by factors that alter its natural, cultural and environmental resources. It should be planned a transportation system less polluting than the existing one, re-evaluating the rehabilitation of the tramway connection between these areas. It should be upgraded the public roads, by improving environmental pathways and their equipment in order to encourage and to increase pedestrian access to the sea. It should also assess the feasibility of mechanical lifts, mini electric buses and marine transport. The three proposals presented here provide a line of small electric buses, that goes from Capo Posillipo to Marechiaro square; a cable railway that starts from the exedra of Coroglio slope gets to the square ; a leaning lift or a lightweight one carriage funicular that travels along the green area between the two roads. The three proposals must be tested functionally, environmentally and technologically. It is interesting to involve residents and traders in the planning.

  17. Mowat-Wilson-syndrom hos tre danske børn

    DEFF Research Database (Denmark)

    Nissen, Karin Bækgaard; Søndergaard, Charlotte; Thelle, Thomas

    2011-01-01

    Mowat-Wilson syndrome (MWS) is an autosomal dominant intellectual disability syndrome characterised by unique facial features and congenital anomalies such as Hirschsprung disease, congenital heart defects, corpus callosum agenesis and urinary tract anomalies. Some cases also present epilepsy......, growth retardation and microcephaly. The syndrome is caused by mutations or deletions of the ZEB2 gene at chromosome 2q22-q23. MWS was first described in 1998 and until now approximately 180 cases have been reported worldwide. We report the first three molecularly confirmed Danish cases with MWS....

  18. Être Normaliens et pratiquants de Mixed Martial Arts

    OpenAIRE

    Quidu, Matthieu; Delalandre, Matthieu

    2018-01-01

    La rencontre est a priori improbable entre d’une part le Mixed Martial Arts (MMA), cette discipline de combat sulfureuse et, d’autre part, les élèves de l’École normale supérieure de Lyon, aux parcours académiques d’excellence. Après avoir déconstruit l’illusion d’une dissonance culturelle en termes de légitimité, nous identifions les significations effectives que les Normaliens investissent dans leur pratique. Celles-ci s’avèrent en grande partie génériques et non spécifiques au MMA (dévelop...

  19. Fulltext PDF

    Indian Academy of Sciences (India)

    Sponsored by: Jawaharlal Nehru Ce~tre for Advanced Scientific Research ... Physical Sciences: Elementary particle and nuclear physics, relativity and ... materials and topics in electronic/electrical engineering and computer science.

  20. Dotsheri Ivana Sõssojeva hotjat vernut prahh ottsa na rodinu / Andrei Babin

    Index Scriptorium Estoniae

    Babin, Andrei

    2007-01-01

    Vene ohvitseri tütre Ezmiralda Menshikova soovist 1944. aastal hukkunud ja Tõnismäele maetud isa Ivan Sõssojevi säilmete ümbermatmisest Venemaale. Punase Risti ja kaitseministeeriumi seisukohtadest

  1. OL Copenhagen 2020: Strategisk utopi?

    DEFF Research Database (Denmark)

    Østergaard, Katrine; Møller Christensen, Søren

    2006-01-01

    Ny rapport anbefaler, at København ansøger om værtskabet for sommer-OL i 2020. Kulturminister Brian Mikkelsen vil tidligst tage stilling til en reel ansøgning om tre år. Der er da også god grund til at tænke sig rigtig godt om, før man engagerer sig med verdens største event......Ny rapport anbefaler, at København ansøger om værtskabet for sommer-OL i 2020. Kulturminister Brian Mikkelsen vil tidligst tage stilling til en reel ansøgning om tre år. Der er da også god grund til at tænke sig rigtig godt om, før man engagerer sig med verdens største event...

  2. Einstein's conversion from his static to an expanding universe

    Science.gov (United States)

    Nussbaumer, Harry

    2014-02-01

    In 1917 Einstein initiated modern cosmology by postulating, based on general relativity, a homogenous, static, spatially curved universe. To counteract gravitational contraction he introduced the cosmological constant. In 1922 Alexander Friedman showed that Albert Einstein's fundamental equations also allow dynamical worlds, and in 1927 Georges Lemaître, backed by observational evidence, concluded that our universe was expanding. Einstein impetuously rejected Friedman's as well as Lemaître's findings. However, in 1931 he retracted his former static model in favour of a dynamic solution. This investigation follows Einstein on his hesitating path from a static to the expanding universe. Contrary to an often advocated belief the primary motive for his switch was not observational evidence, but the realisation that his static model was unstable.

  3. Grèce, pays d’immigration : Perspectives historiques et sociologiques

    Directory of Open Access Journals (Sweden)

    Dimitrios Parsanoglou

    2010-05-01

    Full Text Available Thèse soutenue le 4 mai 2009Composition du JuryMarie - Claude Blanc - Chaléard, Maître de conférences à l’Université Paris 1, Georges Dertilis, Directeur d'études à l’ÉHESS, Nancy Green, Directrice d'études à l’ÉHESS (direction de thèse, Pierre Sintès, Maître de conférences à l’Université de Provence, Maryse Tripier, Professeur émérite à l’Université Paris 7.RésuméCette thèse se divise en trois parties relativement autonomes mais reliées. La première partie, intitulée « L’histoire migratoire...

  4. Le massacre de la mariée

    Directory of Open Access Journals (Sweden)

    Bastiaan van der Velden

    2016-06-01

    Full Text Available Le Massacre des innocents a été pour Marcel Duchamp l’une de ses sources en composant Le Grand Verre. Ce ‘massacre’ est dans ce cas plus précisément une attraction foraine. D’autre part l’infanticide à Bethlehem constitue un sujet maintes fois représenté par différents peintres. Pour Alfred Jarry, auteur littéraire et de théâtre qui a plus particulièrement inspiré Duchamp, le tableau Le Massacre des innocents de Breughel l’Ancien était une pièce clé qui lui permettait de démontrer pourquoi il rejetait l’art historisant en peinture et dans le théâtre.

  5. Dicty_cDB: Contig-U13006-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available A-FP_182294 Lysiphlebus testaceipes adult whol... 34 3.0 2 ( BU896130 ) X036A07 Populus wood cDNA library Populus tremul...1.r GM_WBc Glycine max genomic clone ... 34 2.9 2 ( DN492755 ) X036A07.3pR Populus wood cDNA library Populus tre...... 34 2.9 2 ( DN502768 ) X036A07.5pR Populus wood cDNA library Populus tre... 34 2.9 2 ( EH014215 ) USD..... 34 2.4 2 ( EU795178 ) Uncultured bacterium HF0010_09O16 genomic sequence. 34 2.4 2 ( AC182691 ) Populus tric...itermes flavipes symbiont library ... 36 3.2 2 ( DQ927304 ) Tetrahymena paravorax strain RP m

  6. Hommage à Georges Duby

    Directory of Open Access Journals (Sweden)

    Dominique Iogna-Prat

    2006-09-01

    Full Text Available Dix ans après le décès du grand maître des études médiévales, le temps est sans nul doute venu de revisiter l’œuvre de Georges Duby et d’en discuter l’actualité du point de vue de l’histoire sociale du Moyen Âge. À une seule exception – Claudie Amado, qui fut son assistante –, les historiens invités n’ont pas travaillé au contact direct de Georges Duby ; il leur a été demandé de faire, chacun dans leur domaine, le bilan des apports du maître et de mettre en perspective ses principales thèses ...

  7. Eesti Picasso / Jüri Muttika

    Index Scriptorium Estoniae

    Muttika, Jüri

    2006-01-01

    Mart Kivastiku kunstniketriloogia kolmandas osas "Kits viiuli ja õngega" on peategelane Elmar Kits. Näidendi aluseks on kunstniku päevikud, antud tütre Saskia Kasemaa poolt. Harry Liivranna kommentaar

  8. Üks võõramaine lind

    Index Scriptorium Estoniae

    1999-01-01

    lühirefereering Rootsi maastikuarhitektide ajakirja "Utblick/Landskap" 1998.a. erinumbris "Tre profiler" ilmunud Tove Jonstoj'i 8-leheküljelisest artiklist eesti päritolu aiaarhitektist Hele Lüüsist

  9. Pratiche di Social Networking: una prima sperimentazione nei corsi di italiano L2 per studenti Erasmus

    Directory of Open Access Journals (Sweden)

    Emanuela Cotroneo

    2012-04-01

    Full Text Available Tre Social Network realizzati con ilPratiche di social networking:  web service Ning in affiancamento alla didattica presenziale di alcuni corsi di lingua italiana per studenti Erasmus

  10. Belgia printsessi tervitatakse "Everybody" viisile tehtud lauluga

    Index Scriptorium Estoniae

    2001-01-01

    Belgia kroonprintsessi Mathilde tõi eelmisel nädalal ilmale tütre, kelle nimeks on Elisabeth Therese Marie Helene. Belgia pensionärid tervitasid kroonprintsessi eesti eurolaulu viisile tehtud lauluga

  11. Il desiderio Kitsch: i troppi paradisi di Walter Siti

    Directory of Open Access Journals (Sweden)

    Ornella Tajani

    2013-06-01

    Full Text Available Cosa ne è del desiderio all’interno del Kitsch, sistema in cui la vita è vissuta come uno spot pubblicitario e l’identità come una eterna performance? In una dimensione utopistica in cui l’uomo non cerca altro che una continua soddisfazione come possono trovare spazio le tensioni e le mancanze che muovono il desiderio? Dopo una premessa teorica su cosa è il Kitsch, l’intervento si propone di rispondere al quesito attraverso tre opere di Walter Siti: i romanzi Troppi paradisi e Autopsia dell’ossessione e il reportage narrativo Il canto del diavolo. In queste opere vengono individuati tre paradigmi dell’esperienza Kitsch: il turismo, la televisione e un certo tipo di prostituzione. Indagandone le modalità e analizzando le riflessioni dell’autore in merito si vedrà come si deforma il desiderio quando si trova a dover fare i conti con il perpetuo sforzo del Kitschmensch di camuffarsi, per dirla con Kundera, «dans le miroir du mensonge embellissant et de s’y reconnaître avec une satisfaction émue». La meravigliosa e sostenibilissima leggerezza dell’essere che assurge a cifra interpretativa dell’utopia Kitsch non prevede la presenza del desiderio se non nella sua veste di “realizzabilità”: il desiderio Kitsch, il surrogato del desiderio, è offerto in omaggio col prodotto che lo appaga.

  12. Whole body cooling by immersion in water at moderate temperatures.

    Science.gov (United States)

    Marino, F; Booth, J

    1998-06-01

    This study investigated the potential use of whole body cooling by water immersion for lowering body temperatures prior to endurance exercise. Rectal temperature (Tre), mean skin temperature (Tsk), oxygen consumption (VO2), and ventilation (VE) were measured in 7 male and 3 female subjects who were immersed in a water bath for up to 60 min. Initial water temperature was 28.8+/-1.5 degrees C and decreased to 23.8+/-1.1 degrees C by the end of immersion. Pre-immersion Tre of 37.34+/-0.36 degrees C was not altered by 60 min water immersion but decreased to 36.64+/-0.34 degrees C at 3 min post immersion (p immersion. Reductions in Tre and Tsk resulted in reduced body heat content (Hc) of approximately 545 kJ (p immersion. VO2 and VE increased from pre-immersion values of 0.34+/-0.08 L x min(-1) and 6.2+/-1.4 L x min(-1) to 0.54+/-0.09 L x min(-) and 11.5+/-5.4 L x min(-1) at the end of immersion, respectively. Heart rate remained unchanged throughout immersion. These results indicate that whole body immersion in moderately cold water temperatures is an effective cooling maneuver for lowering body temperatures and body Hc in the absence of severe physiological responses generally associated with sudden cold stress.

  13. Drug: D02810 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available TIKDPAVGFL ETISPGYSIH TYLWRRQ ... ATC code: A16AB01 ... beta-glucocerebrosidase [HSA...:2629] [KO:K01201] [EC:3.2.1.45] ... Alglucerase is glucocerebrosidase derived from human placental tissue. Tre

  14. Maailmaparandajad / Ole Ry, Susanne Andres

    Index Scriptorium Estoniae

    Ry, Ole

    2012-01-01

    Terapeudid Ole Ry ja Susanne Andres räägivad Dr David Berceli loodud TRE (Tension & Trauma Releasing Exercises) harjutuste kasutamise kogemusest erinevate psüühiliste traumade ja pingetega klientide tervise parandamisel

  15. The influence of freeze drying and ϒ-irradiation in pre-clinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using D-(+-trehalose and polyethylene glycol

    Directory of Open Access Journals (Sweden)

    Ramos Yacasi GR

    2016-08-01

    Full Text Available Gladys Rosario Ramos Yacasi, María Luisa García López, Marta Espina García, Alexander Parra Coca, Ana Cristina Calpena Campmany Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain Abstract: This study investigated the suspension of poly(ε-caprolactone nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.5% and submitted individually for freeze-drying and γ-irradiation with polyethylene glycol 3350 (PEG3350 and d-(+-trehalose (TRE. Both formulations satisfied criteria according to all physicochemical parameters required for ocular pharmaceuticals. The FB-PεCL-NP formulations showed non-Newtonian behavior and sustained drug release. Ex vivo permeation analysis using isolated ocular pig tissues suggested that the presence of PEG3350 results in a reduction of FB transcorneal permeation. Moreover, TRE improved the penetration of FB across the cornea, especially after γ-irradiation. In addition, both formulations did not show a significant affinity in increasing FB transscleral permeation. Both formulations were classified as nonirritating, safe products for ophthalmic administration according to hen’s egg test-chorioallantoic membrane and Draize eye test. Furthermore, an in vivo anti-inflammatory efficacy test showed that irradiated FB-PεCL-NPs prepared with PEG3350 (IR-NPsPEG have longer anti-inflammatory effects than those presented with irradiated FB-PεCL-NPs prepared with TRE (IR-NPsTRE. IR-NPsPEG showed a suitable physical stability after an aqueous reconstitution over .30 days. This study concludes that both formulations meet the Goldman’s criteria and demonstrate how irradiated nanoparticles, with innovative permeation characteristics

  16. Assessment of renal artery stenosis of transplanted kidney by time resolved gadolinium-enhanced three-dimensional MR angiography. Preliminary phantom study and clinical evaluation

    International Nuclear Information System (INIS)

    Hayano, Toshio

    2001-01-01

    The purpose of this study was to determine a suitable imaging parameters of time-resolved Gd-enhanced three-dimensional MR angiography (TRE3DMRA) for the evaluation of renal artery stenosis of transplanted kidneys and to investigate the usefulness of TRE3DMRA in 166 clinical cases. Source images were obtained 3dFLASH with zero-filling interpolation (turbo MRA) using Siemens Magneton 1.5T. Acrylate tubes with 6 mm inner diameter filled with diluted Gd-DTPA were used as special phantoms. In the tubes, 25%, 50%, and 75% stenosis were made for simulating arterial stenosis, respectively. According to our clinical experiences, we decided 10 seconds or less acquisition time to obtaining renal artery images without overlapping with renal veins. To determine slice thickness, the degrees of stenosis of the phantom images obtained 8-second acquisition time in variable slice thickness were independently interpreted with visual inspection by two experienced diagnostic radiologists. One hundred sixty-six patients underwent renal transplantation were evaluated clinically. Using a power injector, 0.1 mmol/kg Gd-DTPA was injected after the test scan with 1 ml Gd-DTPA for the determination of acquisition timing. MR images were obtained in the following imaging parameters; 4-mm slice thickness and 8-second acquisition time based on the results of phantom studies. Source images were noted in oblique coronal direction encompassing the entire renal arteries from iliac arteries to renal hili. Based on phantom study, slice thickness must be less than 4-mm to demonstrate the significant stenotic portion (>50%) of the phantom simulating transplanted renal artery. In 150 of 166 patients, excellent images of renal arteries were obtained without overlapping with renal veins. Causes of poor images were mainly inadequate timing of image acquisition. We can decide the imaging parameters of TRE3DMRA for the evaluation of renal artery stenosis of transplanted kidneys. Using these parameters, in 150

  17. Muusikamaailm : Wien Modern 2000. Muusikateater Huddersfieldis. Sibeliuse konkurss Helsingis. Penderecki uus teos Tokyos / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    Nüüdismuusikafestivalist "Wien Modern" 28. okt.-26. nov. Muusikalavastustest Huddersfieldi kaasaegse muusika festivalil. VIII Sibeliuse nim. rahvusvahelisest viiuldajate konkursist. 30. nov. toimus Tokyos K. Penderecki teose "Concerto grosso per tre violoncelli ed orchestra"

  18. Comparative FISH mapping of BMPR1B, BMP15 and GDF9 ...

    Indian Academy of Sciences (India)

    from INRA bovine BAC library (Biological Resources Cen- tre dedicated to livestock ... Iannuzzi L. 2001 International system for chromosome nomen- clature of domestic ... Published on the Web: 6 December 2013. Journal of Genetics, Vol.

  19. Sustainable development applied to the Italian territorial planning, sustainable management of the renewable and un renewable resources; Problematiche territoriali relative al suolo, al sottosuolo, alle acque e contributo allo sviluppo sostenibile nazionale

    Energy Technology Data Exchange (ETDEWEB)

    Basili, M; Colonna, N; Del Ciello, R; Grauso, S; Napoleoni, S; Zarlenga, F [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1998-07-01

    The paper carries out on analysis on the state of the art about sustainable development applied to the territorial planning. Tree types of approach to the sustainability are described: social, economic and environmental, using a large bibliography starting from the Bruntland report. The Italian situation is discussed. An operative proposal on the sustainable management of the renewable and un renewable resources: groundwater, soil and building materials are defined for the Italian context. [Italian] Nel lavoro vengono descritti i principi generali dello sviluppo sostenibile ed i tre tipi di approccio derivanti dall'analisi dell'imponente bibliografia degli ultimi quindici anni, a partire dal rapporto Bruntland che per primo ne ha preso in considerazione i concetti. Vengono proposte tre architetture logiche per procedure di gestione sostenibile delle risorse nel contesto istituzionale italiano.

  20. Macchine per giuoco nella proposta di Leopardi

    Directory of Open Access Journals (Sweden)

    Laura Neri

    2017-06-01

    Full Text Available Un’operetta morale di Leopardi, la Proposta di premi fatta dall’Accademia dei Sillografi, adotta il linguaggio tecnico di un bando di concorso per proporre tre premi agli inventori di tre macchine umane perfette: l’amicizia, la magnanimità, la fedeltà coniugale sono gli obiettivi delle invenzioni scientifiche. Il tono serio cela in realtà la  polemica contro l’antropocentrismo e soprattutto contro l’ottimismo del suo tempo.  One of Leopardi’s Operette morali, Proposta di premi fatta dall’Accademia dei Sillografi, adopts the gergon of a competition notice to propose three prizes to the inventors of three perfect human machines: friendship, magnanimity, conjugal fidelity are the aims of scientific inventions. The serious tone really conceals the controversy against anthropocentrism and above all against the optimism of its time.

  1. Sustainable development applied to the Italian territorial planning, sustainable management of the renewable and un renewable resources; Problematiche territoriali relative al suolo, al sottosuolo, alle acque e contributo allo sviluppo sostenibile nazionale

    Energy Technology Data Exchange (ETDEWEB)

    Basili, M.; Colonna, N.; Del Ciello, R.; Grauso, S.; Napoleoni, S.; Zarlenga, F. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1998-07-01

    The paper carries out on analysis on the state of the art about sustainable development applied to the territorial planning. Tree types of approach to the sustainability are described: social, economic and environmental, using a large bibliography starting from the Bruntland report. The Italian situation is discussed. An operative proposal on the sustainable management of the renewable and un renewable resources: groundwater, soil and building materials are defined for the Italian context. [Italian] Nel lavoro vengono descritti i principi generali dello sviluppo sostenibile ed i tre tipi di approccio derivanti dall'analisi dell'imponente bibliografia degli ultimi quindici anni, a partire dal rapporto Bruntland che per primo ne ha preso in considerazione i concetti. Vengono proposte tre architetture logiche per procedure di gestione sostenibile delle risorse nel contesto istituzionale italiano.

  2. Økologisk Risikovurdering af Genmodificerede Planter i 2008

    DEFF Research Database (Denmark)

    Kjellsson, Gösta; Damgaard, Christian; Strandberg, Morten

    Rapporten giver en oversigt over DMU’s arbejde med økologisk risikovurdering af genmodificerede planter (GMP) i 2008, der understøtter Miljøstyrelsens myndighedsopgave vedrørende økologiske effekter og konsekvenser af GMP. Der var 87 nye forsøgsudsætninger med 15 forskellige plantearter i EU i 2008...... fruktan-rajgræs, mens et forsøg med GM-Gåsemad blev afsluttet. Der var 27 nye markedsføringsansøgninger i EU i 2008: Tre insekt- og herbicidtolerante bomuld, fem herbicidtolerante bomuld, en insektresistent bomuld, otte insekt- og herbicidtolerante majs, tre insektresistente majs, en herbicidtolerant majs...... EU blev der atter dyrket Bt-majs MON810 på 107.725 ha i syv lande med de største arealer i Spanien men ingen i Frankrig....

  3. Avaliação do teste de respiração espontânea na extubação de neonatos pré-termo Spontaneous breathing trial evaluation in preterm newborns extubation

    Directory of Open Access Journals (Sweden)

    Lívia Barboza Andrade

    2010-06-01

    Full Text Available OBJETIVO: O teste de respiração espontânea (TRE antes da extubação fornece informações sobre a capacidade de respirar espontaneamente. O objetivo desse estudo foi verificar se o TRE é preditor de sucesso da extubação. MÉTODOS: Estudo de perfil observacional, longitudinal e prospectivo. Após eleitos para extubação, 60 recém nascidos pré-termo foram divididos em dois grupos: TRE (n= 30, pressão positiva contínua de vias aéreas durante 30 minutos, e controle (n=30, extubados sem o teste. Foram avaliados antes, aos 10, 20 e 30 minutos do grupo TRE, a freqüência respiratória e cardíaca, saturação de pulso de oxigênio e boletim de Silverman e Andersen. Peso, idade gestacional, Apgar, pressão média de vias aéreas, fração inspirada de oxigênio (FiO2 e tempo de cânula orotraqueal foram analisadas intra-grupos e quanto ao sucesso e falha na extubação. O Qui-quadrado para associações das variáveis categóricas e Mann-Whitney para distribuição não-normal. O sucesso na extubação foi 48 horas sem necessidade de reintubação. RESULTADOS: Não houve diferença significante nas variáveis analisadas, exceto pressão média de vias aéreas. As variáveis analisadas durante o TRE (freqüência respiratória e cardíaca, saturação de oxigênio e boletim de Silverman e Andersen não demonstraram alterações significantes. Comparado sucesso e falha na extubação houve diferença significativa para FiO2 e peso atual no controle, indicando que a FiO2 maior e o peso menor indicam falha na extubação. Houve associação significante entre realização do TRE e sucesso na extubação. CONCLUSÃO: Houve associação significante do TRE e o sucesso na extubação, indicando que, no grupo que realizou o teste observou-se maior sucesso na extubação comparado ao controle.OBJECTIVE: Neonates mechanic ventilation weaning has become a major clinical challenge, and constitutes a large portion of neonatal intensive care units

  4. Music and public health - a Nordic Perspective

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    Antologi med bidrag af førende nordiske forskere. Tre dele: 1) Epidemiologisk forskning i musik og sundhed; 2) Teoretiske perspektiver på musik og folkesundhed; 3) Beskrivelse af konkrete musik/sundhedsprojekter med et folkesundhedsperspektiv...

  5. Suppression of Thyroid Hormone Receptor-Mediated Transcription ...

    African Journals Online (AJOL)

    TH)-induced TR-mediated transcription. We further examined the effects of methamidophos on TR-thyroid hormone response element (TRE) binding using the liquid chemiluminescent DNA pull-down assay (LCDPA), and found no dissociation of ...

  6. Spring ud i arbejdet med LGBT+ ligestilling

    DEFF Research Database (Denmark)

    Friis Christensen, Jannick; Voergård-Olesen, Rikke

    2017-01-01

    Det er i hele arbejdspladsens interesse, at medarbejderes trivsel sikres uanset deres kønsidentitet eller seksuelle orientering. Her er tre gode råd til, hvordan man kan skabe et mere rummeligt arbejdsmiljø....

  7. Adaptation dans les zones cruciales au regard des changements ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ) vise à accroître la résilience des populations pauvres dans trois « zones cruciales » au regard des changements climatiques : les bassins hydrographiques, les deltas et les régions semi-arides.

  8. Gender | Page 179 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... et font connaître des solutions pratiques pour la culture des légumineuses à ... Language French ... Language French ... Language French ... Language French ... A project supported by the Canadian International Food Security Research ...

  9. Kusagil struktuurides on kallutatud jõud / Lasse Lehis

    Index Scriptorium Estoniae

    Lehis, Lasse, 1972-

    2010-01-01

    Kõrgete riigiametnike ja poliitikute kohtuasjadest: kauaaegse Baieri peaministri Franz-Josef Straußi tütre Monika Hohlmeieri juhtumist, Prantsusmaa endise peaministri, linnapea ja europarlamendi liikme Alain Juppé kohtulahendist ja Itaalia peaministri Silvio Berlusconi kohtuasjadest

  10. Hvad får rekvirenter, studerende og forskere ud af Videnskabsbutiks-projekter?

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    2003-01-01

    Artiklen beskriver erfaringerne med tre danske videnskabsbutiksprojekte inden for miljøområdet i form af deres baggrund, vidensprocesser i projektforløbet og projekternes efterfølgende betydning for rekvirenter, studerende/vejledere og videnskabsbutik....

  11. The strategic use of evidence on teacher education

    DEFF Research Database (Denmark)

    Bjerre, Jørn; Reimer, David

    2014-01-01

    Denne artikel analyserer tre forskellige rapporter. Alle rapporter omhandler læreruddannelse, er produceret af forskellige analyseinstitutter i Danmark og er brugt som evidens indenfor uddannelsessektoren. Analysen identificerer kritiske metodologiske og konceptuelle forhold, der er relateret til...

  12. Philologikes Paratereseis gia ten proime proslepse ton ergon tu Ch. K. Antersen sten Hellada: He periptose tes ”Historias mias meteras”

    DEFF Research Database (Denmark)

    Nørgaard, Lars

    2010-01-01

    Sproglig litterær analyse af tre græske oversættelser af H.C. Andersens ”Historien om en Moder”. Bidrag til mindekonference for Sophia Scopetea, afholdt 2009 af det Filosofiske Fakultet, Universitetet i Thessaloniki....

  13. Sexospécificités | Page 186 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... et font connaître des solutions pratiques pour la culture des légumineuses à graines ... Langue French ... Langue French ... Langue French ... Langue French ... A project supported by the Canadian International Food Security Research Fund ...

  14. Nye oplysningsforpligtelser på Fondsbørsen

    DEFF Research Database (Denmark)

    Clausen, Nis Jul

    2008-01-01

    Artiklen indeholder en gennemgang og analyse af den nye harmoniserede oplysningsforpligtelser for selskaber der har aktier optaget til notering på de tre nordiske OMX's børser - OMX Nordic Exchanges Copenhagen, Stockholm og Helsinki Udgivelsesdato: august...

  15. Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance.

    Science.gov (United States)

    Arai, Chikako; Arai, Norie; Mizote, Akiko; Kohno, Keizo; Iwaki, Kanso; Hanaya, Toshiharu; Arai, Shigeyuki; Ushio, Simpei; Fukuda, Shigeharu

    2010-12-01

    Trehalose has been shown to evoke lower insulin secretion than glucose in oral saccharide tolerance tests in humans. Given this hypoinsulinemic effect of trehalose, we hypothesized that trehalose suppresses adipocyte hypertrophy by reducing storage of triglyceride and mitigates insulin resistance in mice fed a high-fat diet (HFD). Mice were fed an HFD and given drinking water containing 2.5% saccharide (glucose [Glc], trehalose [Tre], maltose [Mal], high-fructose corn syrup, or fructose [Fru]) ad libitum. After 7 weeks of HFD and saccharide intake, fasting serum insulin levels in the Tre/HFD group were significantly lower than in the Mal/HFD and Glc/HFD groups (P fructose corn syrup/HFD, or Fru/HFD group. Analysis of gene expression in mesenteric adipocytes showed that no statistically significant difference in the expression of monocyte chemoattractant protein-1 (MCP-1) messenger RNA (mRNA) was observed between the Tre/HFD group and the distilled water/standard diet group, whereas a significant increase in the MCP-1 mRNA expression was observed in the Glc/HFD, Mal/HFD, Fru/HFD, and distilled water/HFD groups. Thus, our data indicate that trehalose prevents adipocyte hypertrophy and mitigates insulin resistance in HFD-fed mice by reducing insulin secretion and down-regulating mRNA expression of MCP-1. These findings further suggest that trehalose is a functional saccharide that mitigates insulin resistance. Copyright © 2010 Elsevier Inc. All rights reserved.

  16. Does Acute Normobaric Hypoxia Induce Anapyrexia in Adult Humans?

    Science.gov (United States)

    Seo, Yongsuk; Gerhart, Hayden D; Vaughan, Jeremiah; Kim, Jung-Hyun; Glickman, Ellen L

    2017-06-01

    Seo, Yongsuk, Hayden D. Gerhart, Jeremiah Vaughan, Jung-Hyun Kim, and Ellen L. Glickman. Does acute normobaric hypoxia induce anapyrexia in adult humans? High Alt Med Biol. 18:185-190, 2017.-Exposure to hypoxia is known to induce a reduction in core body temperature as a protective mechanism, which has been shown in both animals and humans. The purpose of this study was to test if acute exposure to normobaric hypoxia (NH) induces anapyrexia in adult humans in association with decreased peripheral oxygen saturation (SpO 2 ). Ten healthy male subjects were seated in atmospheres of normobaric normoxia 21% (NN21), NH 17% (NH17), and 13% (NH13) O 2 for 60 minutes in a counterbalanced manner. Rectal temperature (Tre) was continuously monitored together with the quantification of metabolic heat production (MHP) and body heat storage (S). Baseline physiological measurements showed no differences between the three conditions. SpO 2 was significantly decreased in NH17 and NH13 compared with NN21 (p ≤ 0.001). Tre decreased following 60 minutes of resting in all conditions, but, independent of the conditions, showed no association between Tre and levels of hypoxic SpO 2 . There was also no significant difference in either MHP or S between conditions. The present results showed no evidence of hypoxia-induced anapyrexia in adult humans during 1 hour of resting after exposure to NH either at 13% or 17% O 2 .

  17. Real-time estimation of FLE for point-based registration

    Science.gov (United States)

    Wiles, Andrew D.; Peters, Terry M.

    2009-02-01

    In image-guide surgery, optimizing the accuracy in localizing the surgical tools within the virtual reality environment or 3D image is vitally important, significant effort has been spent reducing the measurement errors at the point of interest or target. This target registration error (TRE) is often defined by a root-mean-square statistic which reduces the vector data to a single term that can be minimized. However, lost in the data reduction is the directionality of the error which, can be modelled using a 3D covariance matrix. Recently, we developed a set of expressions that modeled the TRE statistics for point-based registrations as a function of the fiducial marker geometry, target location and the fiducial localizer error (FLE). Unfortunately, these expressions are only as good as the definition of the FLE. In order to close the gap, we have subsequently developed a closed form expression that estimates the FLE as a function of the estimated fiducial registration error (FRE, the error between the measured fiducials and the best fit locations of those fiducials). The FRE covariance matrix is estimated using a sliding window technique and used as input into the closed form expression to estimate the FLE. The estimated FLE can then used to estimate the TRE which, can be given to the surgeon to permit the procedure to be designed such that the errors associated with the point-based registrations are minimized.

  18. Dynamique de structuration spatio-temporelle des populations de ...

    African Journals Online (AJOL)

    Dynamique de structuration spatio-temporelle des populations de familles de macroinvertébrés dans un continuum lac de barrage-effluent-fleuve issu de périmètre irrigué. Bassin de la Volta (Burkina Faso)

  19. Le cerveau sous effet placebo

    OpenAIRE

    Touzet , Claude

    2017-01-01

    International audience; Comment le fait de croire qu’on nous injecte de la morphine (alors qu’il s’agit de sérum physiologique) peut-il faire disparaître la douleur ? Investigation sur le cerveau sous placebo.

  20. Hvilke emner mener du som praktiserende læge, at der skal forskes i?

    DEFF Research Database (Denmark)

    Ølgod, Jutta

    1997-01-01

    Knapt 100 alment praktiserende læger angav i en enquete, at man efterlyste forskning på en lang række felter. De tre hyppigst nævnte var "lægernes udbrændthed og manglende trivsel", "rygproblemer" og "psykosomatiske problemstillinger". Derudover udtryktes også stor interesse for "læge-patient for......Knapt 100 alment praktiserende læger angav i en enquete, at man efterlyste forskning på en lang række felter. De tre hyppigst nævnte var "lægernes udbrændthed og manglende trivsel", "rygproblemer" og "psykosomatiske problemstillinger". Derudover udtryktes også stor interesse for "læge......-patient forholdet", "definition af lægernes arbejdsområder", "rollen som forebygger og sundhedsfremmer" og "samarbejdsforhold". Resultaterne blev fremlagt på det 3. almenmedicinske forskningsseminar i Køge i 1996. Udgivelsesdato: 1997/7/15...

  1. Interfon

    CERN Multimedia

    Interfon

    2011-01-01

    Pour vos projets d'été... Pensez à nos partenaires... * * * * * Déco 74 Barrisol Faux plafonds tendus et suspendus Isolation phonique plafond Hall d’expo 30, Chemin de la Courbe – Z.I. de Findrol 74130 CONTAMINE SUR ARVE Tél. : 04 50 03 69 75 ou 06 09 78 22 51 www.deco74barrisol.com * * * * * Rhône-Alpes Rénovation 20, Rue Tacon 01100 OYONNAX Tél. : 04 74 73 53 12 www.rhone-alpes-renovation.com * * * * * Entreprise de peinture extérieure et intérieure, revêtements sols et murs, cloisons sèches, isolation, plâtre et produits en plâtre. VAURS 133, Rue St Maurice 01630 CHALLEX Tél. : 04 50 56 37 36 * * * * * - Information bureau du CERN (Bât. 504)   Coopérative : T&...

  2. An ongoing hydro-biogeochemical characterization of a partly drained lowland in a clay till subcatchment

    DEFF Research Database (Denmark)

    Prinds, Christian; Petersen, Rasmus Jes; Iversen, Bo Vangsø

    2016-01-01

    as well as novel approaches e.g. remote sensing using UAV’s (Unmanned Aerial Vehicles commonly known as drones), a newly developed redox probe, and novel uses of geophysical methods. More information about TReNDS can be found at www.nitrat.dk. The project is funded by Innovation Fund Denmark......Riparian lowlands may have significant impact on the catchment nitrate balance. As a part of the strategic research project TReNDS (“Transport and reduction of nitrate in Danish landscapes at various scales”) extensive field investigations have commenced in the Fensholt subcatchment situated within...... Norsminde Fjord catchment, Odder, Denmark. The riparian lowlands are surrounded by a hilly landscape composed of mainly clayey till, and hence the landscape is heavily drained. Drainpipes are either disconnected at the hillslope bordering the riparian lowland or discharging partly through the riparian zone...

  3. Technology Readiness Evaluation For Aluminum Removal And Sodium Hydroxide Regenration From Hanford Tank Waste By Lithium Hydrotalcite Precipitation

    International Nuclear Information System (INIS)

    Sams, T.L.; Massie, H.L.

    2011-01-01

    A Technology Readiness Evaluation (TRE) performed by AREV A Federal Services, LLC (AFS) for Washington River Protection Solutions, LLC (WRPS) shows the lithium hydrotalcite (LiHT) process invented and patented (pending) by AFS has reached an overall Technology Readiness Level (TRL) of 3. The LiHT process removes aluminum and regenerates sodium hydroxide. The evaluation used test results obtained with a 2-L laboratory-scale system to validate the process and its critical technology elements (CTEs) on Hanford tank waste simulants. The testing included detailed definition and evaluation for parameters of interest and validation by comparison to analytical predictions and data quality objectives for critical subsystems. The results of the TRE would support the development of strategies to further mature the design and implementation of the LiHT process as a supplemental pretreatment option for Hanford tank waste.

  4. Teskedsgumman – en publikationshistoria på tre språk

    OpenAIRE

    Sundmark, Björn

    2015-01-01

    The article, ”Mrs Pepperpot: a publication history in three languages,” is an attempt at providing a chronological and comprehensive overview of Alf Prøysen’s Mrs Pepperpot stories. The underlying argument is that only by looking at the publication history of the Mrs Pepperpot books in both Norway, Sweden and Great Britain is it possible to establish a complete corpus of the published stories. The overview shows that 56 stories were published between 1956 and 2010. It also shows a much greate...

  5. Teskedsgumman – en publikationshistoria på tre språk

    Directory of Open Access Journals (Sweden)

    Sundmark, Björn

    2015-01-01

    Full Text Available The article, ”Mrs Pepperpot: a publication history in three languages,” is an attempt at providing a chronological and comprehensive overview of Alf Prøysen’s Mrs Pepperpot stories. The underlying argument is that only by looking at the publication history of the Mrs Pepperpot books in both Norway, Sweden and Great Britain is it possible to establish a complete corpus of the published stories. The overview shows that 56 stories were published between 1956 and 2010. It also shows a much greater degree of correspondence between the Swedish and English publications than with the Norwegian. Finally, a major discrepancy has to do with the varying degree of inclusion (and time of publication of the 26 stories originally issued in the Swedish periodical Veckorevyn 1968–69. The article also charts the publication of Mrs Pepperpot stories in other media, such as periodicals, radio, and TV, and points to the media versatility of the Mrs Pepperpot stories as well as to Prøysen’s own improvisatory storytelling style and his willingness to recycle and remediate his stories.

  6. Tåtourniquetsyndrom hos barn på tre måneder

    DEFF Research Database (Denmark)

    Monrad, Rikke Nygaard; Rytter, Søren

    2011-01-01

    Toe tourniquet syndrome is a rare condition in which a hair or thread becomes tightly wrapped around an appendage, which causes ischaemic strangulation. We present a three month-old infant with strangulation of one toe to direct attention to this condition. Prompt recognition and complete removal...

  7. Tre års erfaringer med epilepsikirurgi på Hvidovre Hospital

    DEFF Research Database (Denmark)

    Rogvi-Hansen, B; Alving, J; Andersen, A R

    1991-01-01

    The results of a retrospective survey of 48 patients submitted to neurosurgery for medically intractable epilepsy are presented. Twenty-eight patients were treated with selective amygdalohippocampectomy, one with temporal lobe resection, 12 with anterior callosotomy and seven with a total calloso....... The callosotomized patients, with two exceptions, were all mentally and physically handicapped. In the callosotomy group, two patients died, one from a intracerebral hematoma three months after the operation and another patient seven months postoperatively from unknown causes....

  8. The power plant among Three Gorges; Kraftstasjonen blant Tre kloefter

    Energy Technology Data Exchange (ETDEWEB)

    Stensvold, Tore

    2003-07-01

    In 2009 the Three Gorges power station on the Yangtze River in China will be completed, with 26 turbines that together will produce 84.60 TWh/year. In this article a Norwegian expert describes his experience from a tourist visit, approaching the plant onboard a cruise ship. In addition to giving the main technical data he comments on peoples' resistance against being transferred, on scepticism and fear of a dam break, on the shortcomings of the power grid and on the not very extensive Norwegian contribution to the world's largest power plant.

  9. Case01: BIM hos mindre arkitektrådgiver

    DEFF Research Database (Denmark)

    Vestergaard, Flemming; Karlshøj, Jan; Hauch, Peter

    Casen beskriver et IKT-koncept, hvor en hovedrådgiver, en mindre arkitektvirksomhed specialiseret i renovering og ombygning af mindre boligprojekter, anvender en modelbaseret arbejdsmetode i tre hovedleverancer for tegnestuen: et dispositionsplanforslag, et forprojekt/myndighedsprojekt og et ho-v...

  10. Case01

    DEFF Research Database (Denmark)

    Vestergaard, Flemming; Karlshøj, Jan; Hauch, Peter

    Casen beskriver et IKT-koncept, hvor en hovedrådgiver, en mindre arkitektvirksomhed specialiseret i renovering og ombygning af mindre boligprojekter, anvender en modelbaseret arbejdsmetode i tre hovedleverancer for tegnestuen: et dispositionsplanforslag, et forprojekt/myndighedsprojekt og et ho-v...

  11. African Journal of Neurological Sciences - 2009 Vol. 28 No 1

    African Journals Online (AJOL)

    et sa franchise pouvaient paraître brutales. Son extrême ... accomplished feats in our medical specialty: providing care and support to epilepsy patients and victims of heart attacks ... incredibly - with a positive financial balance! As always, Eric ...

  12. [Dennis Hormuth. Livonia est omnis divisa in partes tres : Studien zu mental mapping der livländischen Chronistik in der Frühen Neuzeit (1558-1710) ] / Stefan Donecker

    Index Scriptorium Estoniae

    Donecker, Stefan, 1977-

    2014-01-01

    Arvustus: Hormuth, Dennis. Livonia est omnis divisa in partes tre : Studien zu mental mapping der livländischen Chronistik in der Frühen Neuzeit (1558-1710). (Quellen und Studien zur Geschichte des östlichen Europa, 79). Stuttgard, 2012

  13. Skoling af lyst

    DEFF Research Database (Denmark)

    Bjerg, Helle

    2011-01-01

    På baggrund af interview med tre elevgenerationer fremanalyseres skolens virkningsfuldhed i skoling af lyst i et historisk perspektiv. I afhandlingen udvikles to teoretisk-analytiske optikker: Skolen som ideologisk rum - med inspiration fra Slavoj Zizeks ideologikritik, samt Skolen som affektivt...

  14. Muusikamaailm : Bachi orel Leipzigis valmis. XX sajandi ooperid laval. Huddersfieldi festivalil. "Liszt ja Bach" Weimaris / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2000-01-01

    Lepzigi Thomaskirches taastati Bachi-aegne barokkorel. Flandria Ooperis, Hamburgi Riigiooperis ja Brüsseli Thétre de la Monnaie's lavastuvatest XX saj. heliloojate ooperitest. 16.-26. nov. toimuvast Huddersfieldi kaasaegse muusika festivalist Inglismaal. Festivalist "Liszt ja Bach" Weimaris

  15. Anthropogenic and impact spherules: Morphological similarity and ...

    Indian Academy of Sciences (India)

    Spherule; road dust; meteoritic impact; microtektites; fly ash. ... of Allahabad city with sample locations and number of spherules recovered per location shown with ..... Education. T raining. C en tre,. Civil. Lines. L ittle g reenery; heav y traffic. 20.

  16. On the Commercialization of Shostakovich’s ‘Waltz No. 2’

    DEFF Research Database (Denmark)

    Bonde, Anders

    2009-01-01

    Artiklen omhandler ledsagemusiks semantiske potentiale i audiovisuelle medietekster. Som case-studier anvendes tre film (repræsenterende hver sin genre), der alle inddrager Sjosakovitjs "Vals nr. 2" som musikledsagelse. Der er tale om hhv. spillefilmen "Eyes Wide Shut", dokumentarfilmen "Fogh bag...

  17. Genetic differentiation in Gammarus fossarum and G. caparti (Crustacea, Amphipoda) with reference to G. pulex pulex in northwestern Europe

    NARCIS (Netherlands)

    Scheepmaker, Maarten; Dalfsen, van Jan

    1989-01-01

    Genetic differentiation among G. fossarum Koch, 1835 from different stations in Germany, Switzerland, Belgium and northern France, and the closely related Belgian form G. caparti Pètre-Stroobants, 1980 was investigated by electrophoresis at 20 enzyme loci. Although morphologically variable,

  18. Skulptur med dobbel identitet. Gjenbruk av en katolsk madonnaskulptur i et luthersk epitafium = A statue with a dual identity : reuse of a late medieval wooden sculpture in a post-reformation memorial / Rognald Bergesen

    Index Scriptorium Estoniae

    Bergesen, Rognald

    2006-01-01

    Kahese identiteediga puuskulptuurist - katoliku kirikust pärineva Madonna pühakuju kasutamisest abikaasa ja tütre hauatähisena pärast reformatsiooni Vågani kirikus Põhja-Norras. Tänapäeval säilitatakse seda Tromsø Muuseumis

  19. Congenital anomalies: Prospective study of pattern and associated ...

    African Journals Online (AJOL)

    2017-04-02

    Apr 2, 2017 ... tre from high voltage electricity transmission cables. Distances ... 48% in the maternal age group of 26-30 years and drops ... Table 4: Distribution of the anomalies ... (23.1%) and the central nervous system (16.7%) (Table. 4).

  20. Résultats de recherche | Page 16 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    acheminent vers une plus grande intégration économique, on voit apparaître tout un éventail de difficultés interreliées ayant trait aux garanties constitutionnelles et aux garanties des droits de la personn. Projet ...

  1. Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention

    DEFF Research Database (Denmark)

    Fosbøl, Emil L; Ju, Christine; Anstrom, Kevin J

    2016-01-01

    BACKGROUND: Guidelines recommend the use of adenosine diphosphate receptor inhibitor (ADPri) therapy for 1 year postacute myocardial infarction; yet, early cessation of therapy occurs frequently in clinical practice. METHODS AND RESULTS: We examined 11 858 acute myocardial infarction patients tre...

  2. Immunization against east coast fever by infection and treatment ...

    African Journals Online (AJOL)

    testing of the infection and tre:ltment method of immunization against ECF. This method has now been introduced on private farms and it is accepted in ... on days 0 and 4 of sporozoite stahilatc inoculation. This regime of chemotherapy was ...

  3. Hvis din attraktion var et computerspil...-Iscenesættelse af oplevelsesattraktioner

    DEFF Research Database (Denmark)

    Lindof, Thessa; Christensen, Lars Holmgaard; Gram, Malene

    2007-01-01

    Artiklen beskriver en undersøgelse af tre attraktioner (Randers Regnskov, Nordjyllands Kunstmuseum og Storcenteret i Aalborg). Der ses på, hvordan familier med mindre børn oplever attraktionerne, og hvorfor det går galt de fleste steder....

  4. Kenya | Page 94 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Mais si les liquidités que rapporte la culture du tabac sont intéressantes, les planteurs commencent à reconnaître le ... Langue French ... Nations, Stuart Gillespie spent six months examining the connection between HIV/AIDS and food security.

  5. Club's news

    CERN Multimedia

    Clubs

    2006-01-01

    The club of the week: conCERNed for Humanity; Artemusa; Yoga; Pétanque; Orientation; NatureNotre; Ciné-Club (Hannah and her sisters - Shine - Astérix et Obélix : Mission Cléopâtre); Running; Cricket; Concerts Club.

  6. Validating module network learning algorithms using simulated data.

    Science.gov (United States)

    Michoel, Tom; Maere, Steven; Bonnet, Eric; Joshi, Anagha; Saeys, Yvan; Van den Bulcke, Tim; Van Leemput, Koenraad; van Remortel, Piet; Kuiper, Martin; Marchal, Kathleen; Van de Peer, Yves

    2007-05-03

    In recent years, several authors have used probabilistic graphical models to learn expression modules and their regulatory programs from gene expression data. Despite the demonstrated success of such algorithms in uncovering biologically relevant regulatory relations, further developments in the area are hampered by a lack of tools to compare the performance of alternative module network learning strategies. Here, we demonstrate the use of the synthetic data generator SynTReN for the purpose of testing and comparing module network learning algorithms. We introduce a software package for learning module networks, called LeMoNe, which incorporates a novel strategy for learning regulatory programs. Novelties include the use of a bottom-up Bayesian hierarchical clustering to construct the regulatory programs, and the use of a conditional entropy measure to assign regulators to the regulation program nodes. Using SynTReN data, we test the performance of LeMoNe in a completely controlled situation and assess the effect of the methodological changes we made with respect to an existing software package, namely Genomica. Additionally, we assess the effect of various parameters, such as the size of the data set and the amount of noise, on the inference performance. Overall, application of Genomica and LeMoNe to simulated data sets gave comparable results. However, LeMoNe offers some advantages, one of them being that the learning process is considerably faster for larger data sets. Additionally, we show that the location of the regulators in the LeMoNe regulation programs and their conditional entropy may be used to prioritize regulators for functional validation, and that the combination of the bottom-up clustering strategy with the conditional entropy-based assignment of regulators improves the handling of missing or hidden regulators. We show that data simulators such as SynTReN are very well suited for the purpose of developing, testing and improving module network

  7. MO-G-18C-03: Evaluation of Deformable Image Registration for Lung Motion Estimation Using Hyperpolarized Gas Tagging MRI

    International Nuclear Information System (INIS)

    Huang, Q; Zhang, Y; Liu, Y; Hu, L; Yin, F; Cai, J; Miller, W

    2014-01-01

    Purpose: Hyperpolarized gas (HP) tagging MRI is a novel imaging technique for direct measurement of lung motion during breathing. This study aims to quantitatively evaluate the accuracy of deformable image registration (DIR) in lung motion estimation using HP tagging MRI as references. Methods: Three healthy subjects were imaged using the HP MR tagging, as well as a high-resolution 3D proton MR sequence (TrueFISP) at the end-of-inhalation (EOI) and the end-of-exhalation (EOE). Ground truth of lung motion and corresponding displacement vector field (tDVF) was derived from HP tagging MRI by manually tracking the displacement of tagging grids between EOI and EOE. Seven different DIR methods were applied to the high-resolution TrueFISP MR images (EOI and EOE) to generate the DIR-based DVFs (dDVF). The DIR methods include Velocity (VEL), MIM, Mirada, multi-grid B-spline from Elastix (MGB) and 3 other algorithms from DIRART toolbox (Double Force Demons (DFD), Improved Lucas-Kanade (ILK), and Iterative Optical Flow (IOF)). All registrations were performed by independent experts. Target registration error (TRE) was calculated as tDVF – dDVF. Analysis was performed for the entire lungs, and separately for the upper and lower lungs. Results: Significant differences between tDVF and dDVF were observed. Besides the DFD and IOF algorithms, all other dDVFs showed similarity in deformation magnitude distribution but away from the ground truth. The average TRE for entire lung ranged 2.5−23.7mm (mean=8.8mm), depending on the DIR method and subject's breathing amplitude. Larger TRE (13.3–23.7mm) was found in subject with larger breathing amplitude of 45.6mm. TRE was greater in lower lung (2.5−33.9 mm, mean=12.4mm) than that in upper lung (2.5−11.9 mm, mean=5.8mm). Conclusion: Significant differences were observed in lung motion estimation between the HP gas tagging MRI method and the DIR methods, especially when lung motion is large. Large variation among different

  8. MO-G-18C-03: Evaluation of Deformable Image Registration for Lung Motion Estimation Using Hyperpolarized Gas Tagging MRI

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Q; Zhang, Y [Duke University, Durham, NC (United States); Liu, Y [Duke University (United States); Hu, L; Yin, F; Cai, J [Duke University Medical Center, Durham, NC (United States); Miller, W [University of Virginia, Charlottesville, VA (United States)

    2014-06-15

    Purpose: Hyperpolarized gas (HP) tagging MRI is a novel imaging technique for direct measurement of lung motion during breathing. This study aims to quantitatively evaluate the accuracy of deformable image registration (DIR) in lung motion estimation using HP tagging MRI as references. Methods: Three healthy subjects were imaged using the HP MR tagging, as well as a high-resolution 3D proton MR sequence (TrueFISP) at the end-of-inhalation (EOI) and the end-of-exhalation (EOE). Ground truth of lung motion and corresponding displacement vector field (tDVF) was derived from HP tagging MRI by manually tracking the displacement of tagging grids between EOI and EOE. Seven different DIR methods were applied to the high-resolution TrueFISP MR images (EOI and EOE) to generate the DIR-based DVFs (dDVF). The DIR methods include Velocity (VEL), MIM, Mirada, multi-grid B-spline from Elastix (MGB) and 3 other algorithms from DIRART toolbox (Double Force Demons (DFD), Improved Lucas-Kanade (ILK), and Iterative Optical Flow (IOF)). All registrations were performed by independent experts. Target registration error (TRE) was calculated as tDVF – dDVF. Analysis was performed for the entire lungs, and separately for the upper and lower lungs. Results: Significant differences between tDVF and dDVF were observed. Besides the DFD and IOF algorithms, all other dDVFs showed similarity in deformation magnitude distribution but away from the ground truth. The average TRE for entire lung ranged 2.5−23.7mm (mean=8.8mm), depending on the DIR method and subject's breathing amplitude. Larger TRE (13.3–23.7mm) was found in subject with larger breathing amplitude of 45.6mm. TRE was greater in lower lung (2.5−33.9 mm, mean=12.4mm) than that in upper lung (2.5−11.9 mm, mean=5.8mm). Conclusion: Significant differences were observed in lung motion estimation between the HP gas tagging MRI method and the DIR methods, especially when lung motion is large. Large variation among different

  9. Evaluating Effectiveness of Green Infrastructure Application of Stormwater Best Management Practices in Protecting Stream Habitat and Biotic Condition in New England

    Science.gov (United States)

    The US EPA is developing assessment tools to evaluate the effectiveness of green infrastructure (GI) applied in stormwater best management practices (BMPs) at the small watershed (HUC12 or finer) scale. Based on analysis of historical monitoring data using boosted regression tre...

  10. family Vitaceae

    African Journals Online (AJOL)

    use

    crystals were present in all the varieties, the shape of the stem, petiole, midrib, ... anatomically different as well as the presence of trichomes among the varieties. .... 16870 Afr. J. Biotechnol. B. A. C. Figure 5a. Vitis vinifera midrib, A- Tre rash ...

  11. Enzymatic Production of Ceramide

    DEFF Research Database (Denmark)

    Zhang, Long

    organiske fase cirkulerede kontinuerligt. Bland det ti membran som blev afprøvede, bibeholdt enzymet i membranen RC 70PP, men med lav immobiliserings effektivitet. Når tre immobiliserings metoder, filtrering, kovalent binding samt cross-linking sammenlignedes, havde enzym som var immobiliseret ved...

  12. Characterization of Microfibrillar-associated Protein 4 in the Development of Pulmonary Emphysema-like Changes

    DEFF Research Database (Denmark)

    Holm, Anne Trommelholt

    Ph.D.-afhandlingen er baseret på tre karakteriseringsstudier. Disse studier omhandler den strukturalle organisering af mikrofibrillar-associeret protein 4 (MFAP4) og dets interaktion med komponenter af lungevævet. Derudover også den basale karakterisering af de pulmonale konsekvenser associeret m...

  13. Simultaneous detection and serotyping of Salmonellae by immunomagnetic separation and label-free surface enhanced Raman spectroscopy

    Science.gov (United States)

    Salmonella spp. are one of the leading causes of foodborne outbreaks in the United States and globally. Current detection and characterization techniques for Salmonellae are time consuming and costly, and rapid methods could greatly benefit outbreak investigation, new case prevention and disease tre...

  14. Quelle personne!? : naise pilk / Monika Salu

    Index Scriptorium Estoniae

    Salu, Monika

    2006-01-01

    Tallinna Ülikooli kantsler, OÜ Inotex grupp juht ja omanik, Eesti Mittetulundusühingute ja Sihtasutuste Liidu nõukogu liige, Tallinna Nõmme Gümnaasiumi hoolekogu liige, majandusteaduste doktor, kolme tütre ema, naine ja tütar Monika Salu naise rollidest

  15. Per Diem Tables

    International Development Research Centre (IDRC) Digital Library (Canada)

    Marissa Farruggia

    15 avr. 2017 ... Subject to the conditions specified in 8.8.5 (b) of MPM Volume 1 / Taux par kilomètre parcouru. ... The maximum meal allowance paid when an employee is working overtime / l'indemnité maximale pour les .... HONG KONG.

  16. Immigrazione Senegalese in Italia: stato dell¿arte

    NARCIS (Netherlands)

    G. Sinatti (Giulia)

    2007-01-01

    textabstractÈ trascorso ormai circa un trentennio da quando i primi immigrati senegalesi giungevano in Italia nella seconda metà degli anni Ottanta. Nel corso di questi tre decenni, essi hanno stabilmente rappresentato la presenza straniera più significativa in provenienza dall’Africa

  17. Fondamenti di meccanica relativistica redatti dal Prof. E. Persico

    CERN Document Server

    Levi-Civita, T

    1982-01-01

    Evoluzione della meccanica e dell'ottica geometrica, loro subordinazione ad uno schema quadridimensionale secondo Einstein ; le equazioni gravitationali e la relatività generale ; sulla curvatura degli spazi riemanniani a tre dimensioni ; Tullio Regge : il trasporto parallelo di Levi-Civita e sue generalizzazioni.

  18. Alment, afgrænset, altædende

    DEFF Research Database (Denmark)

    Eriksson, Birgit

    2006-01-01

    Artiklen omhandler smagens funktionsforandring. Gennem tre historiske nedslag belyser jeg, hvordan teorierne om den kulturelle smags relation til det sociale liv har forandret sig. Udgangspunktet er den tidligt moderne forestilling om kultivering af smagen, som den blev formuleret af Immanuel Kant...

  19. Quality in VPL

    DEFF Research Database (Denmark)

    Jørgensen, Ulla Nistrup; Hansen, Kirsten Aagaard; Andersson, Per

    2017-01-01

    Artiklen præsenterer den nordiske model for kvalitet i realkomptencer (validering) og kvalitetsbegrebet i forhold til realkompetencer Forskningsprojektets interaktive tilgang bliver kort introduceret. De foreløbige resultater fra tre casestudier i Danmark, Finland og Sverige bliver præsenteret og...

  20. Mellem kommunikation og kreativitet

    DEFF Research Database (Denmark)

    Eriksson, Birgit

    2014-01-01

    Den franske filosof og kunstteoretiker Yves Michaud har argumenteret for, at moderniteten er karakteriseret ved tre utopier: Utopien om demokratisk medborgerskab, arbejdets utopi og kunstens utopi. Kunstens utopi sporer han tilbage til Immanuel Kants æstetik og hans forestilling om, at vi i...

  1. Muuga / Mary von Grünewaldt ; tõlk. Mati Sirkel

    Index Scriptorium Estoniae

    Grünewaldt, Mary von

    2004-01-01

    Leo Zoegelt ostetud Muuga mõisahoone korrastamisest ja uue hoone ehitamisest C. T. von Neffi kunstikogu paigutamise tarbeks. Tütre mälestused. Tõlgitud raamatust: Skizzen und Bilder aus dem Leben Carl Timoleon von Neff / Mary von Grünewaldt. Darmstadt, 1887

  2. Comparison of ambrosia beetle communities in two hosts with laurel wilt: swampbay vs. avocado

    Science.gov (United States)

    The invasive redbay ambrosia beetle, Xyleborus glabratus (Coleoptera: Curculionidae: Scolytinae), is an exotic wood-boring pest first detected in 2002 near Savannah, Georgia. The beetle’s dominant fungal symbiont, Raffaelea lauricola, is the pathogen that causes laurel wilt, a lethal disease of tre...

  3. Fagre hvide verden

    DEFF Research Database (Denmark)

    Hjortsø, Marianne

    2006-01-01

    Artiklen tager afsæt i specialet: Fagre hvide verden. Konstruktion af faglig identitet i tre studiesamtaler i sygeplejeuddannelsen. Ved hjælp af diskurspsykologi (Zimmerman, Antaki og Weddocombe 1998, mikrosociologi (Goffman 1981) og Conversation Analysis - CA (Sacks, Schegloff og Jefferson 1974...

  4. Torsional stresses in the transverse fillet weld tubular joints

    NARCIS (Netherlands)

    Gunay, D.; Aydemir, A.; Özer, H.

    1996-01-01

    Torsional stresses, 'tre and tel , in tbe transverse fillet tubular weld joint subjected to torsional load have been analyzed by the finite element method using triangular and quadrilateral izoparametric axisymmetric fourier type torus finite elements. There is an axisymmetry with respect to

  5. Kenya | Page 88 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Language French ... Mais si les liquidités que rapporte la culture du tabac sont intéressantes, les planteurs commencent à reconnaître le ... In 1989, while working at the Food and Agriculture Organization of the United Nations, Stuart Gillespie ...

  6. HR Public meeting

    CERN Multimedia

    CERN. Geneva

    2010-01-01

    Chef du Département des Ressources humaines *Cette réunion sera retransmise simultanément dans l’Amphithéâtre BE de Prévessin (Bâtiment 864) et également disponible à l’adresse suivante : http://webcast.cern.ch -------------------------------------------------------- ...

  7. 25 Utilisation d'un nouveau bio-floculant extrait de cactus marocain ...

    African Journals Online (AJOL)

    AKA BOKO

    chimique (coagulation floculation) afin de traiter des rejets liquides chargés en chrome. (VI). Ce bio-floculant nous a permis de réduire la turbidité d'un effluent industriel, en .... Spectrophotomètre UV-Visible, type UV-160 mode SHIMADZU.

  8. Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide

    DEFF Research Database (Denmark)

    Hasselbalch, Benedikte; Lassen, Ulrik; Hansen, Steinbjørn

    2010-01-01

    The aim of this clinical trial was to investigate safety and efficacy when combining cetuximab with bevacizumab and irinotecan in patients with recurrent primary glioblastoma multiforme (GBM). Patients were included with recurrent primary GBM and progression within 6 months of ending standard tre...

  9. Multiple embolier efter DC-konvertering hos en patient forbehandlet med dabigatran

    DEFF Research Database (Denmark)

    Buch, Torben Nicolai; Holm, Jakob; Munck, Lars Kristian

    2013-01-01

    A 65-year-old man, who had been treated with dabigatran for 66 days prior to electrical cardioversion, developed extensive intestinal, renal and cerebral thromboembolism five days after cardioversion. There is limited information available on the treatment of thromboembolism in patients being tre...

  10. "To be honest I don´t think she has much to say..."

    DEFF Research Database (Denmark)

    Bjerg, Helle; Lenz, Claudia

    2007-01-01

    Artiklen er baseret på forskningsprojektet 'Traditions of Historical Consciousness', hvor danske og norske familier i tre generationer er blevet interviewet om deres historiebevidsthed om anden verdenskrig. Artiklen fokuserer på køn som analytisk kategori i konstruktionen af nationale og private ...

  11. Optical Sensors based on Raman Effects

    DEFF Research Database (Denmark)

    Jernshøj, Kit Drescher

    Formålet med denne afhandling er at give en systematisk og uddybende videnskabelig diskussion af molekylær Raman spredning, som kan danne grundlag for udviklingen af molekylespecifikke optiske sensorer til on-site, ikke-destruktiv måling. Afhandlingen falder i tre dele, to teoriafsnit, hvor første...... del omhandler den tilgangelige molekylære information ved overfladeforstærket resonans Raman spredning (SERRS), samt hvordan adgangen til denne information kan optimeres. Anden del omhandler, hvordan det molekylære informationsindhold kan forøges ved at kombinere polariserede Raman og resonans Raman...... målinger på frie molekyler med multivariat analyse. I tredje og sidste del, som er et eksperimentelt afsnit, præsenteres og diskuteres overfladeforstærkede Raman målinger (SERS) på tre udvalgte pesticider. Afhandlingen indledes med en diskussion af teorien bag SERRS med speciel fokus på den molekylære...

  12. Functional cooperativity between two TPA responsive elements in undifferentiated F9 embryonic stem cells.

    Science.gov (United States)

    Okuda, A; Imagawa, M; Sakai, M; Muramatsu, M

    1990-01-01

    We have recently identified an enhancer, termed GPEI, in the 5'-flanking region of the rat glutathione transferase P gene, that is composed of two imperfect TPA (phorbol 12-O-tetradecanoate 13-acetate) responsive elements (TREs). Unlike other TRE-containing enhancers, GPEI exhibits a strong transcriptional enhancing activity in F9 embryonic stem cells. Mutational analyses have revealed that the high activity of GPEI is mediated by two imperfect TREs. Each TRE-like sequence has no activity by itself but acts synergistically to form a strong enhancer which is active even in the very low level of AP-1 activity in F9 cells. Furthermore, we show that synthetic DNAs containing two perfect TREs in certain arrangements have strong transcriptional enhancing activities in F9 cells and the activity is greatly influenced by the relative orientation and the distance of two TREs. Images Fig. 1. Fig. 2. Fig. 3. PMID:2323334

  13. Offers

    CERN Multimedia

    Staff Association

    2013-01-01

    Do not hesitate to benefit of our offers in our partners: Théâtre de Carouge Discount of 5 CHF for all shows (30 CHF instead of 35 CHF) and on season tickets « first performance » ( 132 CHF instead 162 CHF) and also on « classical » ( 150 CHF instead of 180 CHF) upon presentation of your Staff Association membership card before payment. Théâtre La Comédie de Genève  20% off on tickets (full price – also available for partner): from 24 to 32 CHF a ticket instead of 30 to 40 CHF depending on the shows. 40% off on annual subscriptions (access to the best seats, pick up tickets at the last minute): 200 CHF for 9 shows (about 22 CHF a ticket instead of 30 to 40 CHF. Discounted card: 60 CHF and single price ticket of 16 CHF.

  14. The Jungle Universe: coupled cosmological models in a Lotka-Volterra framework

    Science.gov (United States)

    Perez, Jérôme; Füzfa, André; Carletti, Timoteo; Mélot, Laurence; Guedezounme, Lazare

    2014-06-01

    In this paper, we exploit the fact that the dynamics of homogeneous and isotropic Friedmann-Lemaître universes is a special case of generalized Lotka-Volterra system where the competitive species are the barotropic fluids filling the Universe. Without coupling between those fluids, Lotka-Volterra formulation offers a pedagogical and simple way to interpret usual Friedmann-Lemaître cosmological dynamics. A natural and physical coupling between cosmological fluids is proposed which preserves the structure of the dynamical equations. Using the standard tools of Lotka-Volterra dynamics, we obtain the general Lyapunov function of the system when one of the fluids is coupled to dark energy. This provides in a rigorous form a generic asymptotic behavior for cosmic expansion in presence of coupled species, beyond the standard de Sitter, Einstein-de Sitter and Milne cosmologies. Finally, we conjecture that chaos can appear for at least four interacting fluids.

  15. Boligmarkedet uden for de store byer

    DEFF Research Database (Denmark)

    Larsen, Jacob Norvig; Andersen, Hans Thor; Haldrup, Karin

    landet som helhed, hvor den østjyske millionby og hovedstaden er migrationens mål. Dermed må der på steder langt fra de store byers infrastruktur og arbejdspladser forventes faldende eller meget begrænset efterspørgsel efter boliger. Det gælder især gamle, dårligt vedligeholdte boliger og boliger med...... og lokalpolitiske planer og indsatser. Tre casestudier belyser, hvordan man i lokalsamfund i tre kommuner uden for de store byer aktivt tager den udfordring op, som følger af en generel strukturændring med øget urbanisering og aldrende befolkning i områderne uden for de store byer. Med blandt andet...... nye samarbejdsformer mellem private, frivillige og kommunale aktører og aktivitets- og beboerhuse som base for foreningsaktivitet er det flere steder lykkedes at tiltrække tilflyttere til samfund langt uden for de store byer....

  16. Brugerdeltagelse og motivation i rehabilitering

    DEFF Research Database (Denmark)

    Christensen, Elsebeth Hovmøller

    2005-01-01

    vil herunder nærmere undersøge, om inddragelse af brugerdeltagelse i en rehabiliteringsproces påvirker borgerens motivation. Vores hypotese er, at brugerdeltagelse øger motivationen hos borgeren, således at borgeren er mere klar til at tage ansvar for egen rehabiliteringsproces og den derved bliver...... brugerdeltagelse og empowerment og om motivation - herunder selvbestemmelse, autonomi, self-efficacy og forholdet mellem læring og motivation. Datamateriale Datamaterialet består seks interview med seks forskellige respondenter, som er strategisk udvalgte. Der er tale om tre kvinder og tre mænd i alderen 26 – 50...... år, der alle er fysisk funktionshæmmede, i arbejde og bosat i Jylland. Interviewene er optaget på bånd og herefter transskriberede Konklusion Konklusionen er, at brugerdeltagelse påvirker borgerens motivation i et rehabiliteringsforløb. Den ønskede grad af brugerdeltagelse er et individuelt...

  17. Antioxidant activity of a new aromatic geranyl derivative of the resinous exudates from Heliotropium glutinosum Phil.

    Science.gov (United States)

    Modak, Brenda; Rojas, Macarena; Torres, René; Rodilla, Jesús; Luebert, Federico

    2007-05-21

    Heliotropium glutinosum Phil. (Heliotropiceae) is a resinous bush that grows at a height of 2000 m in Chañaral, Chile. From the resinous exudates of Heliotropium glutinosum Phil. a new aromatic geranyl derivative: 4-methoxy-3-[(2)-7'-methyl-3'-hydroxymethyl-2',6'-octadienyl] phenol (1) and three flavonoids: 5,3'-dihydroxy-7,4'-dimethoxyflavanone (2), 5,4'-dihydroxy-7-methoxyflavanone (3) and 4'-acetyl-5-hydroxy-7-methoxyflavanone (4) were isolated and their structures were determined. Their antioxidant activity were evaluated using the bleaching of ABTS and DPPH derived cation radical methods and expressed in terms of FRE (fast reacting equivalents) and TRE (total reacting equivalents), where FRE is a good measure of the quick protection of a given compound against oxidants and TRE measures the degree of long-term protection of the antioxidant, or how effective it is against a strong oxidative stress.

  18. ‘My Language! Heavens!’: Strange Tongues and the Denial of Mimesis in The Tempest ‘My Language! Heavens!’ : langues étrangères et déni de la mimesis dans The Tempest

    Directory of Open Access Journals (Sweden)

    Claire Guéron

    2009-06-01

    Full Text Available The Tempest est la dernière pièce « italienne » de Shakespeare. Cet article se penche sur quelques unes des conséquences poétiques et métaphysiques de la convention qui consiste à faire correspondre l’anglais de la pièce à l’italien que sont sensés parler les personnages. Nous montrerons que cette convention est un paramètre essentiel de l’action dramatique et qu’elle contribue à la mise en évidence du caractère fondamentalement « Autre » de la langue du théâtre. Dans The Tempest, l’imbrication d’une langue inconnue et d’une langue familière débouche par métonymie et par métaphore sur un déni du principe classique de mimesis.

  19. Concerts-club

    CERN Multimedia

    Concerts-club

    2012-01-01

      Avis à tous les musiciens et mélomanes Le Concerts-Club du CERN reprend du service ! Après une longue pause due, entre autres, aux travaux de rénovation de l’Amphithéâtre, une nouvelle équipe s’est lancée dans la reprise de l’organisation du Concerts-Club, à raison d’un concert par mois. 1er concert : mardi 20 mars à 20h30 Lieu : CERN-Meyrin : Entrée B – Bâtiment 500 – Amphithéâtre Prochaines dates : Mardi 24 avril 2012 Mardi 15 mai  2012 Mardi 19 juin  2012 Pour donner au Club l’élan nécessaire au redémarrage, les changements suivants ont été mis en place : – Possibilité d’être membre du Club : carte à Fr 25.00 par an. – Entr&e...

  20. Analysis of Point Based Image Registration Errors With Applications in Single Molecule Microscopy.

    Science.gov (United States)

    Cohen, E A K; Ober, R J

    2013-12-15

    We present an asymptotic treatment of errors involved in point-based image registration where control point (CP) localization is subject to heteroscedastic noise; a suitable model for image registration in fluorescence microscopy. Assuming an affine transform, CPs are used to solve a multivariate regression problem. With measurement errors existing for both sets of CPs this is an errors-in-variable problem and linear least squares is inappropriate; the correct method being generalized least squares. To allow for point dependent errors the equivalence of a generalized maximum likelihood and heteroscedastic generalized least squares model is achieved allowing previously published asymptotic results to be extended to image registration. For a particularly useful model of heteroscedastic noise where covariance matrices are scalar multiples of a known matrix (including the case where covariance matrices are multiples of the identity) we provide closed form solutions to estimators and derive their distribution. We consider the target registration error (TRE) and define a new measure called the localization registration error (LRE) believed to be useful, especially in microscopy registration experiments. Assuming Gaussianity of the CP localization errors, it is shown that the asymptotic distribution for the TRE and LRE are themselves Gaussian and the parameterized distributions are derived. Results are successfully applied to registration in single molecule microscopy to derive the key dependence of the TRE and LRE variance on the number of CPs and their associated photon counts. Simulations show asymptotic results are robust for low CP numbers and non-Gaussianity. The method presented here is shown to outperform GLS on real imaging data.

  1. Thermoregulation in reindeer

    Directory of Open Access Journals (Sweden)

    Päivi Soppela

    1986-06-01

    Full Text Available Thermoregulation was studied in Finnish reindeer (Rangifer tarandus L on captive and herded individuals during 1977-85. Newborn calves maintained a high rectal temperature (Tre (+39 to +41°C even at —23°C by increasing heat production 5- to 6-fold through non-shivering thermogenesis, stimulated by cold-induced noradrenaline (NA. Plasma NA and thyroxine (T4 were high (18 ng/ml and 459 nmol/1 in neonatal reindeer. Sensitivity to exogenous NA was lost during the first 3-4 weeks of life. At +20°C and above, calves increased Tre (ca 1°C, oxygen consumption and heart rate, thereby showing poor heat tolerance. Thermal conductance was low in a cold environment, but rose sharply as ambient temperature (Ta increased above + 10°C. The Tre of adults (+ 38 to +39°C was independent of Ta (—28 to +15°C. Coarse (hollow hair density and length in adults averaged 2000/cm2 and 12 mm on the legs, 1000/cm3 and 30 mm on the abdomen and 1700/cm2 and 30 mm on the back (calves 3200/cm2, 10 mm, respectively. The dependence of skin temperature on the Ta was linear in excised fur samples, but complex in living animals being strongest in the legs. Serum adrenaline correlated with the weight, age and total lipids. Serum NA and dopamine-fi-hydroxylase were highest in spring and decreased by autumn. Serum T4 was highest in summer and lowest in spring.

  2. Spotlight census of the red fox (Vulpes vulpes and the domestic cat (Felis catus in three sample areas of the Marches region (Central Italy / Censimento notturno di Volpe (Vulpes vulpes e di Gatto domestico (Felis catus in tre aree campione delle Marche

    Directory of Open Access Journals (Sweden)

    Massimo Pandolfi

    1991-07-01

    Full Text Available Abstract In order to evaluate the density of the red fox and of the domestic cat, 55 transects were made from 1986 to 1989 using spotlight census method in three sample areas. The mean density of foxes agreed substantially with its biological cycle and the hightes values (2.01 foxes/km² in spring and 4.3 foxes/km² in winter were recorded in the study area with the better natural characteristics. Foxes selected the shrub woodland (macchia all year round, the inhabited area in spring. The domestic cat was widely spread and abundant, and selected especially inhabited areas where the density varied from 4.27 cats/km² (in winter to 12.42 cat/km² (in spring. Riassunto Dal 1986 al 1989, con il metodo dei percorsi notturni con fari, sono stati effettuati complessivamente 55 conteggi in tre aree campione per valutare la densità della Volpe (Vulpes vulpes e del Gatto domestico (Felis catus nonché le loro preferenze ambientali limitatamente ad una zona campione. Per la Volpe le densità medie rilevate sono sostanzialmente in accordo con il ciclo biologico della specie e quelle più elevate (2,O1 volpi/km² in primavera e 4,3 volpi/km² in inverno sono state registrate nella zona campione con maggior presenza di boschi ed aree incolte. La Volpe seleziona le zone con vegetazione "di macchia" in ogni periodo dell'anno, e le aree abitate in primavera. Per il Gatto domestico le densità rilevate evidenziano la presenza di una diffusa ed abbondante popolazione. La specie mostra una spiccata preferenza per le aree abitate dove raggiunge densità di 4,27 individui/km² e 12,42 individui/km² in inverno e primavera rispettivamente.

  3. The betwixt and between family class

    DEFF Research Database (Denmark)

    Knudsen, Hanne

    2009-01-01

    Artiklen analyserer familieklassen gennem tre teoretiske perspektiver. Først som empowerment teknologi ved hjælp af Michel Foucaults begreb om selvteknologi og governmentality. Dertil trækkes på det systemteoretiske begreb om sociale styringsteknologier, og endelig trækkes begrebet om "boundary o...

  4. Soutien organisationnel de la phase 2 de l'ITT : Grupo FARO | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La recherche pour influencer les politiques ... -accroître la visibilité du Grupo FARO dans les médias et les cercles d'élaboration de ... TTI Phase 2 Institutional Support: Fundacio´n Salvadoren~a para el Desarrollo Econo´mico y Social.

  5. Les Burkinabè du Gabon : une migration à l'aune des aléas ...

    African Journals Online (AJOL)

    24 juin 2015 ... dans le cadre de la politique de recrutement de main-d'œuvre initiée .... dans les entreprises de construction qui tentent de promouvoir la culture ...... Le Gabon peut apparaître dans les stratégies migratoires burkinabè comme.

  6. Résultats de recherche | Page 44 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Une étude examine les liens qui existent entre la protection sociale et la ... Programme de recherche sur le virus Zika Canada-Amérique latine et ... Le salaire minimum n'est pas toujours le meilleur moyen d'accroître le bien-être social.

  7. Cute and Cool in Contemporary Japanese Visual Arts

    DEFF Research Database (Denmark)

    Borggreen, Gunhild Ravn

    2011-01-01

    Med udgangspunkt i officiel japansk promovering af tre unge kvinder inden for modebranchen som kulturambassadører inden for "Japan Cool" diskuterer artiklen forskellige kulturelle aspekter af det japanske begreb kawaii (nuttet) som både brand for japansk kultureksport og som et kritisk subversivt...

  8. Meninger er gratis - og næsten umulige at måle

    DEFF Research Database (Denmark)

    Andersen, Steffen; Nielsen, Hans Jørgen

    2015-01-01

    Gang på gang rammer meningsmålinger forkert - senest ved parlamentsvalget i Storbritannien. Det er der mindst tre gode grunde til, at de vil blive ved med. Men der findes en metode, som giver bedre pejlinger: Køb aktier i et forventet valgresultat...

  9. Technological change as social proces

    DEFF Research Database (Denmark)

    Jamison, Andrew

    2004-01-01

    The article distinguishes between different meanings that technology has as well as the different 'roles' that technologies play in society. udfoldes tre forståelser af teknologisk forandring. Der sigtes på at fremstille forskellige meningsdannelser, som i sit samspil konstituerer et samfunds opf...

  10. Group Contribution sPC-SAFT Equation of State

    DEFF Research Database (Denmark)

    Tihic, Amra

    2008-01-01

    Modellering af termodynamiske egenskaber og faseligevægte er en udfordring for den kemiske industri. Forenklet Perturbed Chains-Statistical Associating Fluid Theory (sPC-SAFT) er en tilstandsligning med udbredt anvendelse i en række industrielle sammenhænge. Modellen anvender tre parametre: segment...

  11. Effect of Methamidophos on cerebellar neuronal cells | Ibhazehiebo ...

    African Journals Online (AJOL)

    We have previously reported that methamidophos suppressed thyroid hormone receptor (TR)-mediated transcription, but did not dissociate the interaction between TR and its response element (thyroid hormone response element; TRE), neither did it interact with nuclear cofactors. In the present study, we investigated the ...

  12. APPUNTI PASOLINIANI PER UN'ORESTIADE AFRICANA

    African Journals Online (AJOL)

    User

    in versi del 1964, L'uomo di Bandung, in P. P. Pasolini, Bestemmia, a cura di G. Chiarcossi e W. Siti ... aver visitato Bombay, Calcutta e Nuova Delhi, in febbraio i tre amici ..... africani mossi dal vento, nei silenzi sovraumani, nel cieco istinto di.

  13. Observations on Ecology and National Security

    Science.gov (United States)

    1975-03-01

    central business district.8"* To others, human ecology is concerned almost solely with the interaction between the human species and pathogenic ... aphid population," in Animal Populations in Relation to Their Food Resources. Blackwell, Oxford, England (1970). 14. T.R.E. Southwood and

  14. Når sex er en ret, hvem har så pligt?

    DEFF Research Database (Denmark)

    Munk-Madsen, Eva

    2007-01-01

    Socialministeriet har fastslået i en vejledning, at samfundet har omsorgspligt for funktionshæmmedes borgeres  seksuelle udfoldelsesmulighder. Tre grupper er udpeget som dem der skal varetage denne omsorgspligt på samfundets vegne: ansatte hjælpepersoner, seksualvejledere og prostituerede. I modt...

  15. Stjerner med hjerner

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2007-01-01

    Hvordan inspireres pædagogiske forskere, og hvad bruger de inspirationen til? Læs om tre engagerede forskere, der i særlig grad er blevet inspireret af én bestemt teoretiker - Staf Callewaert, Bente Elkjær og Susanne V. Knudsen Udgivelsesdato: Februar...

  16. Den gode blasfemi

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.

    2014-01-01

    Dette bidrag til Henning Kochs festskrift diskuterer hans karakteristiske forsvar for blasfemiparagraffen, som det har udfoldet sig i forbindelse med Jyllandspostens kontroversielle Muhammedtegninger. Bidraget indeholder en kritik af dette forsvar, og det falder i følgende tre dele. For det først...

  17. : tous les projets | Page 200 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Université Carleton à Ottawa, à faire paraître trois volumes de Canada Among Nations (CAN), ouvrage dont on a dit qu'il s'agissait des meilleures annales publiées au pays sur les relations internationales du Canada. End Date: 18 janvier ...

  18. Soutien organisationnel de la phase 2 de l'ITT : Asociación de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Son programme de recherche est axé sur l'économie, les sciences politiques ... inclusif dans une société multiculturelle, la croissance économique et l'éducation; ... -accroître son capital humain et mobiliser ses ressources afin d'assurer une ...

  19. Ecological periodic tables for bentkhic macrofauna and nekton usage in estuarine habitats

    Science.gov (United States)

    In his presidential address to the British Ecological Society, T.R.E. Southwood (1977: Habitat, the templet for ecological strategies? Journal of Animal Ecology 46: 337-365; http://www.jstor.org/stable/3817) compared the situation in ecology to that in chemistry before the devel...

  20. STATUS OF WOOD PROCESSING AND STORAGE IN NIGERIA

    African Journals Online (AJOL)

    ES Obe

    [5] Dry wood has good insulating prop- erties against heat, sound, and electricity. It tends to absorb and ... Wood is primarily com- posed of hollow, elongate, spindle-shaped cells ... (F), a small core of tissue located at the cen- tre of tree stems, ...

  1. Feltarbejde i demokratiets tjeneste

    DEFF Research Database (Denmark)

    Mogensen, Kirsten; Skovbo, Stig; Kok Hansen, Ib

    Forord ved Jørgen Elklit og Merete Bech Seeberg. Bogen er skrevet af tre erfarne valgobservatører på opfordring fra NIRAS, som administrerer Udenrigsministeriets Freds og Stabiliserings Beredskab (FSB). Den indeholder en kombination af forsknings-baseret viden, praktiske erfaringer fra arbejdet s...

  2. Digital kulturarvsformidling

    DEFF Research Database (Denmark)

    Jensen, Jens F.

    2010-01-01

    Der er tre fremtrædende tendenser i aktuel museums- og kulturarvsformidling. Den første er den kreative inddragelse af nye teknologier - især digitale, interaktive teknologier - i udstillingsdesign og i repræsentationen af udstillingsobjekter. Den anden er brugen af nye oplevelsesorienterede...

  3. Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

    DEFF Research Database (Denmark)

    Zhuang, Hongqin; Jiang, Weiwei; Cheng, Wei

    2010-01-01

    Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) has recently emerged as a cancer therapeutic agent because it preferentially induces apoptosis in human cancer over normal cells. Most tumor cells, including lung cancer cell line A549, unfortunately, are resistant to TRAIL tre...

  4. Dicty_cDB: Contig-U11234-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Y327498 |pid:none) Actinoplanes missouriensis glycoge... 564 e-159 CP000908_2675( CP000908 |pid:none) Methyl.... trifol... 559 e-157 EF364109_2( EF364109 |pid:none) Actinoplanes sp. SN223/29 treS gen... 559 e-157 CP0008

  5. Valutasikring og insiderhandel : belyst juridisk, finansielt og regnskabsmæssigt

    DEFF Research Database (Denmark)

    Clausen, Nis Jul; Pedersen, Frank; Thinggaard, Frank

    Valutasikring og insiderhandel behandler de tre vigtige emner fra Danmarkshistoriens første dom om insiderhandel med aktier: finansiel valutasikring, sikring i årsregnskabet og reglerne om insiderhandel. Ved eksempler analyseres, om det virkelig er rigtigt, at oplysninger om tab på kommercielle v...

  6. Når mødet med livet bliver et møde med døden

    DEFF Research Database (Denmark)

    Flodager, Helle

    2009-01-01

    Begrebsanalysen undersøger, hvilken aktuel status begrebet sorg i relation til perinatal spædbarnsdød har i sygeplejedisciplinen. Hertil anvendes Rodgers metodiske og filosofiske begrebsforståelse. De tre aspekter definition, betydning og anvendelse giver information om begrebets aktuelle status og...

  7. Caries og de nye nationale indkaldeintervaller

    DEFF Research Database (Denmark)

    Ekstrand, Kim; Bruun, Gitte; Bakhshandeh, Azam

    2015-01-01

    obligatorisk at gøre under de nye retningslinjer. Det gennemgås, hvilke behandlinger der er relevante for patienten i forhold til de tre cariesdiagnoser: Caries dentalis progressiva superficialis (CS), Caries dentalis progressiva media (CM) og Caries dentalis progressiva profunda (CP). Diagnoserne angiver...

  8. Reactive transport modeling of uranium 238 and radium 226 in groundwater of the Königstein uranium mine, Germany

    Science.gov (United States)

    Nitzsche, O.; Merkel, B.

    Knowledge of the transport behavior of radionuclides in groundwater is needed for both groundwater protection and remediation of abandoned uranium mines and milling sites. Dispersion, diffusion, mixing, recharge to the aquifer, and chemical interactions, as well as radioactive decay, should be taken into account to obtain reliable predictions on transport of primordial nuclides in groundwater. This paper demonstrates the need for carrying out rehabilitation strategies before closure of the Königstein in-situ leaching uranium mine near Dresden, Germany. Column experiments on drilling cores with uranium-enriched tap water provided data about the exchange behavior of uranium. Uranium breakthrough was observed after more than 20 pore volumes. This strong retardation is due to the exchange of positively charged uranium ions. The code TReAC is a 1-D, 2-D, and 3-D reactive transport code that was modified to take into account the radioactive decay of uranium and the most important daughter nuclides, and to include double-porosity flow. TReAC satisfactorily simulated the breakthrough curves of the column experiments and provided a first approximation of exchange parameters. Groundwater flow in the region of the Königstein mine was simulated using the FLOWPATH code. Reactive transport behavior was simulated with TReAC in one dimension along a 6000-m path line. Results show that uranium migration is relatively slow, but that due to decay of uranium, the concentration of radium along the flow path increases. Results are highly sensitive to the influence of double-porosity flow. Résumé La protection des eaux souterraines et la restauration des sites miniers et de prétraitement d'uranium abandonnés nécessitent de connaître le comportement des radionucléides au cours de leur transport dans les eaux souterraines. La dispersion, la diffusion, le mélange, la recharge de l'aquifère et les interactions chimiques, de même que la décroissance radioactive, doivent être

  9. Treinamento físico durante a recuperação nutricional não afeta o metabolismo muscular da glicose de ratos La educación física durante la recuperación nutritiva no afecta el metabolismo muscular de la glucosa en ratones Physical training during nutritional recovery does not affect the muscular glucose metabolism in rats

    Directory of Open Access Journals (Sweden)

    Vanessa Santhiago

    2006-04-01

    Full Text Available O presente estudo visou avaliar a ingestão alimentar, ganho de peso e metabolismo muscular da glicose em ratos submetidos ao treinamento aeróbio durante recuperação de desnutrição protéica. Para isso, 60 ratos da linhagem Wistar, machos, foram separados nos grupos normoprotéico (NP e hipoprotéico (HP, de acordo com a dieta NP (17% de proteína ou HP (6% de proteína, respectivamente, recebida do desmame (21 dias aos 90 dias de idade. Todos os animais passaram então, a receber a dieta NP e foram submetidos (treinado TRE ou não (sedentário - SED ao treinamento físico, que consistiu de corrida em esteira rolante, 25m/min, 50 minutos ao dia, cinco dias na semana, durante 30 dias, compondo os grupos NP-SED, NP-TRE, HP/NP-SED e HP/NP-TRE. Foi avaliado o metabolismo da glicose em fatias de músculo sóleo incubado em presença de insulina (100miU/L e glicose (5,5mM, contendo [C14] glicose e [H³] 2-deoxiglicose. A ingestão alimentar diária (g/100g de peso corporal do grupo HP/NP-TRE (24,39 ± 4,07 foi maior do que o grupo HP/NP-SED (21,62 ± 4,69. O ganho de peso (g foi semelhante nos grupos HP/NP-TRE (203,80 ± 34,03 e HP/NP-SED (214,43 ± 30,54. Não houve diferença entre estes dois grupos quanto aos parâmetros: captação de glicose, oxidação de glicose e síntese de glicogênio pelo músculo sóleo. Desse modo, pudemos concluir que o treinamento aeróbio não teve impacto sobre a recuperação nutricional, visto que não houve diferenças metabólicas ou somáticas entre animais recuperados em presença ou ausência do treinamento.El estudio presente buscó evaluar la ingestión alimentaría, y la ganancia de peso y el metabolismo muscular de la glucosa en ratones sometidos al entrenamiento aeróbico durante la recuperación protéica de la desnutrición. Para esto, 60 ratones del linaje Wistar, los varones estaban separados en grupos: normoprotéico (NP e hipoprotéico (HP, de acuerdo con la dieta NP (17% de proteína o HP (6

  10. The Politics of Humanitarian Technology

    DEFF Research Database (Denmark)

    Jacobsen, Katja Lindskov

    Med udgangspunkt i teori og koncepter fra Michel Foucaults værker,såvel som indsigter fra Science and Technology Studies (STS), udforsker bogen tre forskellige eksempler på humanitære aktørers brug af ny teknologi: vacciner, genmodificerede majs og biometrisk registreringsteknologi....

  11. Mechanical Stresses in Carotid Plaques

    DEFF Research Database (Denmark)

    Samuel, Samuel Alberg

    simulationer, som tillod beregning af longitudinelle stress-niveauer i den fibrøse kappe. Afhandlingen indeholder tre artikler, som beskriver denne metode. Den første; “Mechanical Stresses in Carotid Plaques using MRI-Based Fluid Structure Interaction Models”, beskriver i detaljer metoden til at danne de...

  12. Moreno

    International Development Research Centre (IDRC) Digital Library (Canada)

    nos, como la gestión de residuos sólidos, la vulne- rabilidad y agricultura ... tre 1991 y 2001, lo cual está muy por encima del promedio del Gran Buenos Aires. Argentina. Moreno ... nueva gestión integrada de residuos sólidos urbanos el.

  13. Kabaree kaminaserval ehk ehisskulptuuri õitseaeg sajandi algul / Mirjam Peil

    Index Scriptorium Estoniae

    Peil, Mirjam, 1939-

    1998-01-01

    Art deco pisiplastikast, millele moodne interjöör pakkus sobivaid paiku. Skulptorite armastatuim tegelane - moodne naine. Materjalidest, meelistehnikast -krüüselelefantiinist. Tegutsenud kunstnikke: saksa skulptor Ferdinand Preiss, Pariisis tegutsenud rumeenlane Dem̊tre Chiparus, belglanna Claire-Jeanne-Roberte Colinet, Marcel Bouraine, austerlane Bruno Zach

  14. Amet kohustab / Sandra Peetso

    Index Scriptorium Estoniae

    Peetso, Sandra

    2008-01-01

    18.-22. okt. Pärnu teatris Endla toimunud rahvusvahelisest laste- ja noorteteatrite festivalist "NB festival 2008". Pikemalt lavastustest "Võimaluste aed" (Prantsuse teatritrupp Association 16 rue de Plaisance), "Sailor & Pekka" (Rootsi teater TRE), "Misantroop" (VAT-teater), "Maria Bonita" (Taani teater Batida), "Avatud ring" (Leedu teatrilabor Open Circle)

  15. Mellem musik, litteratur og oplysning

    DEFF Research Database (Denmark)

    Michelsen, Morten

    2015-01-01

    Michelsen har fokus på mellemkrigstiden og specielt blik for de radiofoniske genrer i en mere generel diskussion. Formålet er at opstille en samlet typologi for mellemkrigstidens genrer for at kunne kode de enkelte udsendelser i en database. Michelsen opstiller tre hovedkategorier: udsendelser ba...

  16. Hjemkomst til Homer

    DEFF Research Database (Denmark)

    Skyum-Nielsen, Erik

    2015-01-01

    Erik Skyum-Nielsen beskriver i sin artikel hvordan tre moderne danske forfattere, Bjørnvig, Nordbrandt og Rifbjerg, har henvist til og genbrugt de homeriske digte eller motiver herfra i deres digtning. Med udgangspunkt i Gérard Genettes overbegreb transtekstualitet viser Skyum-Nielsen os først...

  17. Filaggrin and skin reactivity to irritants - Epidemiological and Experimental studies

    DEFF Research Database (Denmark)

    Bandier, Josefine

    2015-01-01

    grupper i henhold til børneeksem og filaggrinmutationsstatus. Vi analyserede hudens reaktion over for en kendt hudirriterende detergent, natrium lauryl sulfat (SLS), ved tre forskellige doser (0,25, 0,50 og 1% SLS). Graden af barrierepåvirkning blev vurderet ved laser Doppler flowmetry, transepidermalt...

  18. Vidensbaseret indsats over for udsatte børn i dagtilbud - modelprogram - uddannelse og implementering

    DEFF Research Database (Denmark)

    VIDA-modelrapport 2 præsenterer den samlede uddannelses- og implementeringsproces, der har fundet sted i VIDA-projektet 2011-2013. Rapporten beskriver i detaljer, hvordan VIDA-uddannelsesforløbet er bygget op i tre faser samt det curriculum, uddannelsen var bygget op over. Rapporten er udarbejdet...

  19. Lektoranmodning

    DEFF Research Database (Denmark)

    Lewinsky, Anne-Dorte

    2017-01-01

    I denne lektoranmodningen reflekteres over undervisning og udvikling ved Sygeplejerske-uddannelsen i Svendborg. Anmodningen er forankret i tre områder: Det første er i grunduddannelsen, hvor der reflekteres over de studerendes læringsforud-sætninger ved undervisningen i faget Biokemi. Dewey’s...

  20. Atomoxetine/Methylphenidate Effects on Social Play Behavior

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2015-02-01

    Full Text Available Researchers at Utrecht University, The Netherlands, and University “Roma Tre,” Rome, Italy, studied the neural substrates of the previously identified social play-suppressant effects of methylphenidate (MPH and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorder (ADHD.

  1. DNA EMP Awareness Course Notes. Supplement to Third Edition.

    Science.gov (United States)

    1978-07-31

    produce withes then ctomagnet fedsnn the- additional interior fields (SGEMP) and anseles enor i strcin te veoiat chas TRE effects through interaction of...ATTN: R. Plebuch ATTN: B. Gasten ATTN: 0. Adams ATTN: G. Carpenter ATTN: H. Holloway ATTN: W. Gargaro Systems, Science & Software, Inc. ATTN: L

  2. Præstationsledelse gentænkt

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård; Sørensen, Niels Henrik

    2016-01-01

    smidige styrings- og vurderingssystemer, som er integreret i en dagligdags ledelsespraksis, der nedbryder KPI’er, opstiller meningsfulde mål og giver kontinuerlig, konkret og konstruktiv feedback. Vi diskuterer, med afsæt i tre caseeksempler, faldgruber i en klassisk tilgang til præstationsledelse og...

  3. Résultats de recherche | Page 158 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Compétences, gouvernance et nanotechnologies : pleins feux sur l'Inde. La nanotechnologie est la fabrication ou l'utilisation de matières ayant des dimensions comprises entre 1 et 100 nanomètres (1 mètre = 1 milliard de nanomètres) environ. Projet ...

  4. Multiculturalità ottomana e scrittori italiani da Saul Israel a Miro Silvera e Daniel Fishman

    NARCIS (Netherlands)

    Speelman, R.M.

    2007-01-01

    Dall’ex Impero Ottomano, società multiculturale per eccellenza, della quale facevano parte fra l’altro Grecia e Bulgaria, Siria, Egitto, Libia e Israele, provengono molti ebrei scrittori in lingua italiana. Esaminiamo tre di essi: Saul Israel, scienziato nato a Selanik (Salonicco) e autore di un

  5. Mellem deltagelse og publikumsudvikling

    DEFF Research Database (Denmark)

    Bjørnsen, Egil; Hansen, Louise Ejgod; Vatne, Ingrid

    2015-01-01

    Aarhus 2017 (Aarhus som europæisk kulturhovedstad). Vi undersøger, hvor-dan de positionerer sig i feltet mellem den brede deltagelsesdiskurs og den snævre publikumsudviklingsdiskurs ved at se på tre forskellige dimensioner: produkt- vs. modtagerorientering, holdnings- vs. handlingsændring og empowerment...

  6. Emissioner af SO2 og NOX fra kraftværker

    DEFF Research Database (Denmark)

    Illerup, J. B.; Bruun, H. G.

    Rapporten indeholder beregninger af SO2- og NOx- emissioner fra kraftværker, der er reguleret af kvoteloven. Emissionerne er for tre forskellige produktionsscenarier beregnet ud fra emissionsfaktorer baseret på EU-direktivet om store forbrændingsanlæg og emissionsfaktorer beregnet ud fra en...

  7. Résultats de recherche | Page 434 | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... point et diffuser des techniques d''embouche et des pratiques agrofo-restières permettant d''accroître la sécurité alimentaire des exploitat. Published date. 29 août 2014. Rapports. FLOOD CONTROL URBAN POPULATION COMMUNITY PARTICIPATION URBAN PLANNING VULNERABLE GROUPS BUILDING DESIGN ...

  8. Anvendelse af webkonference på Syddansk Universitet

    DEFF Research Database (Denmark)

    Kjær, Christopher; Christensen, Inger-Marie F.; Blok, Rasmus

    2009-01-01

    Artiklen videregiver en række praktiske erfaringer med anvendelse af webkonferencesystemet Adobe Connect Pro i forbindelse med undervisning på Syddansk Universitet (SDU). Via tre pilotprojekter fra forskellige fagområder præsenteres de første konkrete og indledende erfaringer med anvendelsen af det...

  9. Examen de la visualisation de données (version abrégée)

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    3). » [TRADUCTION LIBRE]. Le présent examen évalue les possibilités qu'offre ... 3 sations sont bien conçues, elles peuvent non seu- lement accroître la ...... Now You See It: Simple Visu- ... Information is Beautiful, ... “Choosing Colors for Da-.

  10. Ecological periodic tables for US Pacific Northwest estuarine habitats

    Science.gov (United States)

    In his presidential address to the British Ecological Society, T.R.E. Southwood (1977; J Anim Ecol (1977), 46: 337-365) compared the situation in ecology to that in chemistry before the development of the periodic table when each fact, for example, the solubility or reactivity of...

  11. Politik og organisation, organisation og politik

    DEFF Research Database (Denmark)

    Christensen, Jørgen Grønnegård

    2006-01-01

    Artiklen beskæftiger isg med samspillet mellem politiske og organisatoriske variable i analysen af administrativ adfærd. Gennem tre casestudier beslyses situationer, hvor skift i politiske præferencer og politisk dagsorden sklår umiddelbart igennem i administrativ praksis (Udlændingestyrelsen), h...

  12. Hvordan kan det selvstyrende team kvalificere sine arbejdsprocesser?

    DEFF Research Database (Denmark)

    Bro, Kirsten

    2015-01-01

    Artiklen beskriver tre processer, beslutningsprocesser, forhandlingsprocesser og læringsprocesser, der har hvert sit særkende. Styringen af disse processer set i relation til den fælles opgave, ses som en mulig vej til kvalificering af teamsamarbejdet. Af Kirsten Bro, cand.pæd.psyk...

  13. Det indskrevne publikum i politiske kommentarer

    DEFF Research Database (Denmark)

    Bengtsson, Mette

    2016-01-01

    I denne artikel fremsættes en kritik af kommentargenren i en dansk kontekst. Med udgangspunkt i 90 kommentarartikler fra landsdækkende aviser under folketingsvalget i 2011 laves en analyse af genrens indskrevne publikum efter Edwin Blacks analyseforskrifter i tre trin: Først analyseres materialet...

  14. Frihedens ø, lighedens landevej og broderskabets sten

    DEFF Research Database (Denmark)

    Ladegaard, Jakob

    2010-01-01

    filosof Jacques Rancière udvikler afhandlingens indledning en teoretisk ramme for forståelsen af romantikkens revolutionerende litteraturopfattelse og dens mulige forbindelse til demokratisk teori og praksis. I de tre følgende hovedafsnit udmøntes det teoretiske afsæt i historisk og filosofisk...

  15. Retten til privathed i det danske sundhedsvæsen

    DEFF Research Database (Denmark)

    Bjerre, Hanne Pihl; Juel Vang, Katrine

    2014-01-01

    på en tilfredsstillende måde. Artiklens primære perspektiv er deontologisk, men for at nuancere vores diskussion inddrages lejlighedsvist også utilitaristiske argumenter. Endvidere inddrages i artiklen Helen Nissenbaum, Tom L. Beauchamp og James F. Childress samt John Rawls. I artiklen vil tre...

  16. Fra kulturmøde til fragmentet og 'den anden'

    DEFF Research Database (Denmark)

    Madsen, Ulla Ambrosius

    2017-01-01

    Artiklen introducerer til tre postkoloniale teorier - Edward Said, Homi Bhabha og Jean Baudrillard. Med inddragelse af etnografisk materiale skrevet frem som fragmenter diskuteres hvilke konsekvenser det får for vores forståelse af kulturmøde, når det reflekteres ind i postkoloniale teoridannelser....

  17. Effects of Mushroom and Herb Polysaccharides on Cellular and Humoral Immune Responses of Eimeria tenella-Infected Chickens

    NARCIS (Netherlands)

    Guo, F.C.; Kwakkel, R.P.; Williams, B.A.; Parmentier, H.K.; Li, W.K.; Yang, Z.Q.; Verstegen, M.W.A.

    2004-01-01

    We investigated the effects of polysaccharide extracts from 2 mushrooms, Lentinus edodes (LenE) and Tremella fuciformis (TreE), and an herb, Astragalus membranaceus (AstE), on cellular and humoral immune responses of Eimeria tenella-infected chickens. A total of 150 broiler chicks were assigned to 5

  18. Coccidiosis Immunization: Effects of Mushroom and Herb Polysaccharides on Immune Responses of Chickens Infected with Eimeria Tenella

    NARCIS (Netherlands)

    Guo, F.C.; Kwakkel, R.P.; Williams, B.A.; Suo, X.; Li, W.K.; Verstegen, M.W.A.

    2005-01-01

    An experiment was conducted to investigate the effects of polysaccharide extracts (E) of two mushrooms, Lentinus edodes (LenE) and Tremella fuciformis (TreE), and an herb, Astragalus membranaceus (AstE), on the immune responses of chickens infected with Eimeria tenella. A total of 180 broiler

  19. The relational model is dead, SQL is dead, and i don't feel so good myself

    DEFF Research Database (Denmark)

    Atzeni, Paolo; Jensen, Christian S .; Orsi, Giorgio

    2013-01-01

    on Conceptual Modeling. The panelists include: Paolo Atzeni (Università Roma Tre, Italy), Umeshwar Dayal (HP Labs, USA), Christian S. Jensen (Aarhus University, Denmark), and Sudha Ram (University of Arizona, USA). Quotations from movies are used as a playful though effective way to convey the dramatic changes...

  20. ouargla

    African Journals Online (AJOL)

    O. Melouah*, A. Zeddouri

    erreurs dans le choix de l'indice ... l'intervention du paramètre humain, Thompson (1982),a développé un algorithme mathématique ... champ de potentiel, la méthode a était utilisé pour la localisation des corps à fort contraste.

  1. Populariseringen af Sjostakovitjs “Vals nr. 2”

    DEFF Research Database (Denmark)

    Bonde, Anders

    2008-01-01

    komposition, og på den anden side den betydning, der realiseres via musikkens interaktion med andre semiotiske ressourcer, nonverbale og verbale, visuelle og auditive. Jeg har valgt tre genremæssigt forskellige eksempler, hvori valsen indgår; nemlig spillefilmen Eyes Wide Shut (Kubrick, 1999), en reklamefilm...

  2. Information from the Cultural Kiosk - Geneva Welcome Centre (UNOG)

    CERN Multimedia

    2010-01-01

    The Geneva Welcome Centre has the pleasure to inform you that the Cultural Kiosk at the UNOG is now able, thanks to a new partnership with FNAC, to sell tickets for a number of additional cultural events, among others those of the Grand Théâtre de Genève.   To celebrate this new feature,   the Grand Théâtre de Genève   in association with the Geneva Welcome Centre and the magazine UN Special   has decided to make a special offer for its next performance,   Francesco Cavalli's " La Calisto "   which will be represented from 13 April to 28 April 2010.   This offer is meant for international civil servants, members of diplomatic missions as well as official delegates under presentation of their legitimation or accreditation card. The tickets at the reduced price can be bought at the Cultural Kiosk (door 6).   This opera, rarely performed, will...

  3. IT Project Portfolio Management: Vertical and Horizontal Work Design Problems in a Public Organization

    DEFF Research Database (Denmark)

    Hansen, Lars Kristian

    2013-01-01

    arbejder på at forbedre dens IT PPM praksisser. Undersøgelsen anvender Work Design Teori til at analysere kommunens IT PPM praksisser på tværs af hierarkiske niveauer og organisatoriske enheder i bestræbelsen på, at besvare følgende tre forskningsspørgsmål:(1) Hvordan udfører en offentlig organisation...... and Van De Ven’s (2005) Work Design Teori, der sondrer mellem vertikal- og horisontal arbejdsdeling. Vertikal deling af arbejde bliver betragtet som fordelingen af autoritet, viden og resurser, hvilket undersøgelsen finder værende delt ud på fire hierarkiske niveauer: (1) det politiske niveau med den...... af det andet forskningsspørgsmål anvendes Work Design Teori til at identificere problemer indenfor tre relaterede problemområder: hierarkiske dekompositions problemer, modularitets problemer og komplekse netværks problemer. De identificerede problemer er sammenfattet i en model bestående af 14...

  4. IT Project Portfolio Management: Vertical and Horizontal Work Design Problems in a Public Organization

    DEFF Research Database (Denmark)

    Hansen, Lars Kristian

    dansk kommune, der arbejder på at forbedre dens IT PPM praksisser. Undersøgelsen anvender Work Design Teori til at analysere kommunens IT PPM praksisser på tværs af hierarkiske niveauer og organisatoriske enheder i bestræbelsen på, at besvare følgende tre forskningsspørgsmål:(1) Hvordan udfører en...... at trække på Sinha and Van De Ven’s (2005) Work Design Teori, der sondrer mellem vertikal- og horisontal arbejdsdeling. Vertikal deling af arbejde bliver betragtet som fordelingen af autoritet, viden og resurser, hvilket undersøgelsen finder værende delt ud på fire hierarkiske niveauer: (1) det politiske...... kommunens IT projektgrupper. I besvarelsen af det andet forskningsspørgsmål anvendes Work Design Teori til at identificere problemer indenfor tre relaterede problemområder: hierarkiske dekompositions problemer, modularitets problemer og komplekse netværks problemer. De identificerede problemer er...

  5. Quantization ambiguities and bounds on geometric scalars in anisotropic loop quantum cosmology

    Science.gov (United States)

    Singh, Parampreet; Wilson-Ewing, Edward

    2014-02-01

    We study quantization ambiguities in loop quantum cosmology that arise for space-times with non-zero spatial curvature and anisotropies. Motivated by lessons from different possible loop quantizations of the closed Friedmann-Lemaître-Robertson-Walker cosmology, we find that using open holonomies of the extrinsic curvature, which due to gauge-fixing can be treated as a connection, leads to the same quantum geometry effects that are found in spatially flat cosmologies. More specifically, in contrast to the quantization based on open holonomies of the Ashtekar-Barbero connection, the expansion and shear scalars in the effective theories of the Bianchi type II and Bianchi type IX models have upper bounds, and these are in exact agreement with the bounds found in the effective theories of the Friedmann-Lemaître-Robertson-Walker and Bianchi type I models in loop quantum cosmology. We also comment on some ambiguities present in the definition of inverse triad operators and their role.

  6. Identifying depression among adolescents using three key questions

    DEFF Research Database (Denmark)

    Haugen, Wenche; Haavet, Ole Rikard; Sirpal, Manjit Kaur

    2016-01-01

    Depression rammer mange voksne mennesker. Dette studie, som er omtalt i BMJ, viser, at et spørgeskema med blot tre spørgsmål ret præcist kan identificere voksne med depression. Undersøgelsen viser også, at de samme spørgsmål med fordel kan stilles verbalt ved diagnosticering af depression hos unge...... mennesker. Studiet ledsages af en redaktionel kommentar, der understreger betydningen af diagnosticering af depression hos mennesker. Mange unge har kun sjældent kontakt med deres praktiserende læge. Derfor kan mange gå i lang tid med depression, uden at det bliver opdaget og behandlet. De tre enkle...... spørgsmål, der kredser om interesse (eller mangel på interesse) for daglige aktiviteter og følelser som nedtrykthed eller håbløshed, kan være et godt pejlemærke for evt. depression hos unge, som ellers let kan blive overset....

  7. Deinococcus gobiensis cold shock protein improves salt stress tolerance of escherichia coli

    International Nuclear Information System (INIS)

    Jiang Shijie; Wang Jin; Yang Mingkun; Chen Ming; Zhang Wei; Luo Xuegang

    2013-01-01

    The Deinococcus gobiensis I-0, an extremely radiation-resistant bacterium, isolated from the Gobi, has superior resistance to abiotic stress (e.g radiation, oxidation, dehydration and so on). The two cold-shock proteins encoded by csp1 (Dgo_CA1136) and csp2 (Dgo_PA0041) were identified in the complete genome sequence of D. gobiensis. In this study, we showed that D. gobiensis Csp1 protected Escherichia coli cells against cold shock and other abiotic stresses such as salt and osmotic shocks. The quantitative real-time PCR assay shows that the expression of trehalose synthase (otsA, otsB) was up-regulated remarkably under salt stress in the csp1-expressing strain, while no difference in the expression of the genes involved in trehalose degradation (treB and treC). The results suggested that Csp1 caused the accumulation of the trehalose was a major feature for improving tolerance to salt stress in E. coli. (authors)

  8. Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen

    Directory of Open Access Journals (Sweden)

    Klaus Bruhn Jensen

    2008-06-01

    Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.

  9. Lyd som kommunikation. En tværfaglig forskningsoversigt og en dagsorden for medieforskningen

    Directory of Open Access Journals (Sweden)

    Klaus Bruhn Jensen

    2006-06-01

    Full Text Available Lyden har ikke noget videnskabeligt hjem – i modsætning til f.eks. faste og levende billeder, der traditionelt er blevet studeret af henholdsvis kunsthistorien og filmvidenskaben. Denne artikel giver en oversigt over de mange, meget forskellige slags forskning om lyd. Formålet er at stimulere og kvalificere mere medieforskning om lyd. Hovedvægten ligger på lyd som kommunikation i og omkring medierne – som en kilde til mening og en ressource i social og kulturel handling, snarere end på lyd i et teknisk eller akustisk perspektiv (se f.eks. Plomp, 2002. Første del af artiklen gennemgår forskellige humanistiske og samfundsvidenskabelige tilgange til lydens tre grundformer – tale, musik og soundscapes eller lydmiljøer. Det midterste afsnit diskuterer den tidligere forsknings relevans for forskellige slags medier; artiklen skelner her mellem tre grader af medier. Og artiklens sidste del samler de tværfaglige indsigter i en dagsorden for (meget mere medieforskning om lyd som kommunikation.

  10. Du texte mis entre parenthèses au texte dit à part

    Directory of Open Access Journals (Sweden)

    Xavier Leroux

    2010-12-01

    Full Text Available L’étude de l’aparté dans La Celestina est ici fondée sur une approche codicologique de plusieurs imprimés de l’œuvre de Fernando de Rojas. Une définition théorique de l’aparté permet d’en préciser les différentes réalisations au théâtre : l’aparté au public, l’aparté sélectif et l’aparté au moi, qui se distingue nettement du monologue. Dans le texte dramatique, le repérage de cette forme dramatique se révèle cependant plus délicate. L’étude de l’emploi des parenthèses dans plusieurs imprimés qui conservent La Celestina fait apparaître un usage très vigilant de ces signes de ponctuation pour marquer le recours à l’aparté.

  11. Rugby-metoden SCRUM

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Pries-Heje, Lene

    2012-01-01

    En ny måde at bedrive projekter på breder sig i disse år med overraskende fart. Selv om de første tanker om ”Scrum” – hvor navnet og fremgangsmåden er inspireret af Rugby-spillet – blev tænkt for mere end 10 år siden, så er det først nu at fremgangsmåden for alvor har vundet udbredelse i Danmark....... Denne artikel gennemgår metoden og fortæller om både positive resultater og udfordringer i tre danske organisationer: Et softwarehus, en bank, og et universitet. De tre cases illustrer meget forskellige anvendelsessituationer af Scrum set i forhold til projekternes størrelse, karakter og den...... organisatoriske kontekst. Artiklen slutter med at diskutere, hvad det er der gør, at Scrum er blevet så populær, og i dag fremstår som et reelt alternativ til klassisk plandreven projektledelse...

  12. Rugby-metoden SCRUM: En ny måde at bedrive projekter på

    DEFF Research Database (Denmark)

    Pries-Heje, Lene; Pries-Heje, Jan

    2012-01-01

    En ny måde at bedrive projekter på breder sig i disse år med overraskende fart. Selv om de første tanker om ”Scrum” – hvor navnet og fremgangsmåden er inspireret af Rugby-spillet – blev tænkt for mere end 10 år siden, så er det først nu at fremgangsmåden for alvor har vundet udbredelse i Danmark....... Denne artikel gennemgår metoden og fortæller om både positive resultater og udfordringer i tre danske organisationer: Et softwarehus, en bank, og et universitet. De tre cases illustrer meget forskellige anvendelsessituationer af Scrum set i forhold til projekternes størrelse, karakter og den...... organisatoriske kontekst. Artiklen slutter med at diskutere, hvad det er der gør, at Scrum er blevet så populær, og i dag fremstår som et reelt alternativ til klassisk plandreven projektledelse...

  13. Tv-reklamens musik i et tekstanalytisk perspektiv

    Directory of Open Access Journals (Sweden)

    Nicolai Jørgensgaard Graakjær

    2010-05-01

    Full Text Available Denne artikel omhandler musik i tv-reklamer i et tekstanalytisk perspektiv. Der tilbydes en analytisk ramme, som involverer tre sammenhængende niveauer: tekst, ko-tekst og kontekst. Niveauet for kontekst præsenteres som et spørgsmål om transtekstualitet omhandlende relationen mellem musikken i tv-reklamen og musik udenfor tv-reklamen. Niveauet for ko-tekst præsenteres som et spørgsmål om relationerne mellem tv-reklamens tekstuelle elementer, og der identificeres et primært niveau for audiovisuel betydningsdannelse. Tekst niveauet præsenteres som et spørgsmål om struktureringen af selve musikken i tv-reklamer, og der identificeres en række forskellige musikformater. Hvert af de tre niveauer er diskuteret og differentieret i forhold til yderligere en række analytiske kategorier, og gennemgående er disse analytiske kategorier eksemplificeret med reference til tv-reklamer vist på dansk tv.

  14. Når specialer gør en forskel

    DEFF Research Database (Denmark)

    Dirckinck-Holmfeld, Lone; Iversen, Torben; Konnerup, Ulla

    2008-01-01

    I denne antologi fremlægger og diskuterer en række forskere deres konkrete erfaring med og overvejelser over didaktisk design og brugen af digitale medier i forskellige undervisnings- og læringskontekster fra grundskole til universitetsniveau. Bogens tre dele behandler: Børns og unges brug af dig...

  15. Trialkyltin rexinoid-X receptor agonists selectively potentiate thyroid hormone induced programs of xenopus laevis metamorphosis

    NARCIS (Netherlands)

    Mengeling, Brenda J.; Murk, Albertinka J.; Furlow, J.D.

    2016-01-01

    The trialkyltins tributyltin (TBT) and triphenyltin (TPT) can function as rexinoid-X receptor (RXR) agonists. We recently showed that RXR agonists can alter thyroid hormone (TH) signaling in a mammalian pituitary TH-responsive reporter cell line, GH3.TRE-Luc. The prevalence of TBT and TPT in the

  16. Metoder til den børnefaglige undersøgelse

    DEFF Research Database (Denmark)

    Sørensen, Kresta Munkholt

    Denne afhandling omhandler rammerne for sagsbehandlingen i forhold til udsatte børn, unge og deres familier. Afhandlingen er centreret omkring, hvordan socialarbejderne oplever metoderne til den børnefaglige undersøgelse, og er udarbejdet i et komparativt perspektiv med fokus på følgende tre...

  17. Vandfugle i Vadehavet 1996-99

    DEFF Research Database (Denmark)

    Laursen, K.; Frikke, J.

    1999-01-01

    Denne rapport præsenterer Miljø- og Energiministeriets seks feltstationer med beskrivelse af deres historie, naturforhold og overvågningsprogram. Resultaterne af fugleobservationer i 1997 beskrives i sammenhæng med tidligere års udvikling. Desuden præsenteres resultater af tre undersøgelser af he...

  18. Tællinger af vandfugle i Danmark 1998-99

    DEFF Research Database (Denmark)

    Pihl, S.; Laubek, B.

    1999-01-01

    Denne rapport præsenterer Miljø- og Energiministeriets seks feltstationer med beskrivelse af deres historie, naturforhold og overvågningsprogram. Resultaterne af fugleobservationer i 1997 beskrives i sammenhæng med tidligere års udvikling. Desuden præsenteres resultater af tre undersøgelser af he...

  19. International study of flashbulb and event memory of 9/11

    DEFF Research Database (Denmark)

    Shapiro, Lauren; Hansen, Tia; Polage, Danielle

    2005-01-01

    Det her præsenterede uddrag af en større international spørgeskemaundersøgelse med ca. 1100 deltagere fra fire amerikanske stater og tre europæiske nationer (Danmark, Holland, England) undersøger sammenhænge mellem nationalitet, alder, metakognition, medieforbrug og hukommelse for begivenhederne ...

  20. Distribution spatiale du singe à ventre rouge, Cercopithecus ...

    African Journals Online (AJOL)

    danger et endémique du Dahomey Gap est très peu documenté au Togo. Pour connaître sa ..... chaque secteur prospecté ainsi que celui du complexe en entier. ..... 2008-009 portant loi-cadre sur l'environnement au Togo. JO du 06 juin. 2008.

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