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Sample records for transfer division asme

  1. 46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

  2. Report on the FY17 Development of Computer Program for ASME Section III, Division 5, Subsection HB, Subpart B Rules

    Energy Technology Data Exchange (ETDEWEB)

    Swindeman, M. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Jetter, R. I. [Argonne National Lab. (ANL), Argonne, IL (United States); Sham, T. -L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    One of the objectives of the high temperature design methodology activities is to develop and validate both improvements and the basic features of ASME Boiler and Pressure Vessel Code, Section III, Rules for Construction of Nuclear Facility Components, Division 5, High Temperature Reactors, Subsection HB, Subpart B (HBB). The overall scope of this task is to develop a computer program to aid assessment procedures of components under specified loading conditions in accordance with the elevated temperature design requirements for Division 5 Class A components. There are many features and alternative paths of varying complexity in HBB. The initial focus of this computer program is a basic path through the various options for a single reference material, 316H stainless steel. However, the computer program is being structured for eventual incorporation all of the features and permitted materials of HBB. This report will first provide a description of the overall computer program, particular challenges in developing numerical procedures for the assessment, and an overall approach to computer program development. This is followed by a more comprehensive appendix, which is the draft computer program manual for the program development. The strain limits rules have been implemented in the computer program. The evaluation of creep-fatigue damage will be implemented in future work scope.

  3. Activated sludge models ASM1, ASM2, ASM2d and ASM3

    DEFF Research Database (Denmark)

    Henze, Mogens; Gujer, W.; Mino, T.

    This book has been produced to give a total overview of the Activated Sludge Model (ASM) family at the start of 2000 and to give the reader easy access to the different models in their original versions. It thus presents ASM1, ASM2, ASM2d and ASM3 together for the first time.Modelling of activated...... sludge processes has become a common part of the design and operation of wastewater treatment plants. Today models are being used in design, control, teaching and research.ContentsASM3: Introduction, Comparison of ASM1 and ASM3, ASM3: Definition of compounds in the model, ASM3: Definition of processes...... in the Model, ASM3: Stoichiometry, ASM3: Kinetics, Limitations of ASM3, Aspects of application of ASM3, ASM3C: A Carbon based model, Conclusion ASM 2d: Introduction, Conceptual Approach, ASM 2d, Typical Wastewater Characteristics and Kinetic and Stoichiometric Constants, Limitations, Conclusion ASM 2...

  4. Activated sludge models ASM1, ASM2, ASM2d and ASM3

    DEFF Research Database (Denmark)

    Henze, Mogens; Gujer, W.; Mino, T.

    sludge processes has become a common part of the design and operation of wastewater treatment plants. Today models are being used in design, control, teaching and research.ContentsASM3: Introduction, Comparison of ASM1 and ASM3, ASM3: Definition of compounds in the model, ASM3: Definition of processes...... in the Model, ASM3: Stoichiometry, ASM3: Kinetics, Limitations of ASM3, Aspects of application of ASM3, ASM3C: A Carbon based model, Conclusion ASM 2d: Introduction, Conceptual Approach, ASM 2d, Typical Wastewater Characteristics and Kinetic and Stoichiometric Constants, Limitations, Conclusion ASM 2...... Oxidation Nitrification and Denitrification, Characterization of Wastewater and Estimation of Parameter Values, Typical Parameter Ranges, Default Values, and Effects of Environmental Factors, Assumptions, Restrictions and Constraints, Implementation of the Activated Sludge Model...

  5. Activated sludge models ASM1, ASM2, ASM2d and ASM3

    DEFF Research Database (Denmark)

    Henze, Mogens; Gujer, W.; Mino, T.

    This book has been produced to give a total overview of the Activated Sludge Model (ASM) family at the start of 2000 and to give the reader easy access to the different models in their original versions. It thus presents ASM1, ASM2, ASM2d and ASM3 together for the first time.Modelling of activated......: Introduction, ASM 2, Typical Wastewater Characteristics and Kinetic and Stoichiometric Constants, Wastewater Characterization for Activated Sludge Processes, Calibration of the ASM 2, Model Limitations, Conclusion, Bibliography ASM 1: Introduction, Method of Model Presentation, Model Incorporating Carbon...... Oxidation Nitrification and Denitrification, Characterization of Wastewater and Estimation of Parameter Values, Typical Parameter Ranges, Default Values, and Effects of Environmental Factors, Assumptions, Restrictions and Constraints, Implementation of the Activated Sludge Model...

  6. Report No. 3 -- Background of the factors of safety used in Divisions 1 of Sections III and XI of the ASME rules for nuclear vessels

    International Nuclear Information System (INIS)

    Cooper, W.E.

    1993-01-01

    This paper was prepared in 1984 as a quick background summary of the factors of safety used in the various Code rules as they apply to Class 1 reactor pressure vessels (RPVs). This document should be interpreted as the individual viewpoint of the author on the matters under discussion. The general approach followed is to cite basic reference documents, to lead the reader to the more important aspects which are pertinent to the subject material, and to provide a viewpoint on additional rules which might be either needed or desirable. After a discussion of the differences between Sections 3 and 11 in categorizing the loadings to be considered, the sequence of consideration is as follows: (1) The rules of the code that control initial construction, Section 3, Division (Construction = materials + design + examination + testing + inspection + certification). (2) The rules of Section 3 that specifically affect operation, Appendix G, which forms the basis of the pressure-temperature limits of the Technical Specifications. (3) The rules of Section 11 as they affect ''Acceptance by Examination'' and ''Acceptance by Evaluation''. (4) The special considerations of: (a) Limits for Emergency and Faulted Conditions (b) Elastic-Plastic Fracture Mechanics (c) Low Upper-Shelf Energy (USE) Materials (d) Pressure Thermal Shock (PTS)

  7. ASME Material Challenges for Advanced Reactor Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Piyush Sabharwall; Ali Siahpush

    2013-07-01

    This study presents the material Challenges associated with Advanced Reactor Concept (ARC) such as the Advanced High Temperature Reactor (AHTR). ACR are the next generation concepts focusing on power production and providing thermal energy for industrial applications. The efficient transfer of energy for industrial applications depends on the ability to incorporate cost-effective heat exchangers between the nuclear heat transport system and industrial process heat transport system. The heat exchanger required for AHTR is subjected to a unique set of conditions that bring with them several design challenges not encountered in standard heat exchangers. The corrosive molten salts, especially at higher temperatures, require materials throughout the system to avoid corrosion, and adverse high-temperature effects such as creep. Given the very high steam generator pressure of the supercritical steam cycle, it is anticipated that water tube and molten salt shell steam generators heat exchanger will be used. In this paper, the ASME Section III and the American Society of Mechanical Engineers (ASME) Section VIII requirements (acceptance criteria) are discussed. Also, the ASME material acceptance criteria (ASME Section II, Part D) for high temperature environment are presented. Finally, lack of ASME acceptance criteria for thermal design and analysis are discussed.

  8. Cisco ASM Router

    CERN Multimedia

    2001-01-01

    One of the two "ASM/2-32EM" boxes installed in 1988, from "Cisco Systems Inc." - then an unknown 20-employee company in Menlo Park, California (USA). This is one of the first two Cisco boxes to appear in Switzerland, and possibly Europe. The 220v power supply was a special modification made for use at CERN. They supported IP address filtering, which seemed just what CERN needed to help protect the new Cray XMP-48 super computer from network hackers. The two ASM boxes were both routers and terminal servers. They protected a secure private Ethernet segment used by the Cray project, as well as providing secure terminal connections to that segment, including CERN's first dialback terminal service, which allowed Cray and CERN system analysts to work on the machine from home, using another Cisco feature called TACACS. (Kindly offered by B. Segal who discovered this company while at a Usenix Conference in Phoenix, Arizona in June 1987.)

  9. Accelerator System Model (ASM) user manual with physics and engineering model documentation. ASM version 1.0

    International Nuclear Information System (INIS)

    1993-07-01

    The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the open-quotes constructionclose quotes of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc

  10. Application of ASME code AG-1 to YGN 3 ampersand 4 plants, South Korea

    International Nuclear Information System (INIS)

    Kim, Y.K.; Porco, R.D.; York, Y.D.

    1993-01-01

    Yonggwang Nuclear Power Plant Units 3 ampersand 4 are located on the southwestern coast of South Korea on the Yellow Sea. The plant is owned by Korea Electric Power Corp. (KEPCO), with the engineering being performed by Korea Power Engineering Co., Inc. (KOPEC) and Sargent and Lundy under a technology transfer agreement. The plants are both 950 Megawatt (electric) pressurized water reactors of US design. Under contract to KEPCO, Korea Heavy Industries and Construction Co., Ltd. and Ellis and Watts, Division of Dynamics Corporation of America, Batavia, Ohio, supplied major components to the YGN plants in compliance to ASME AG-1. These components included safety related Air Cleaning Units, Reactor containment Fan Cooler Units, Air Handling Units, Cubicle Coolers, Duct Electric Heaters, and fans. This paper details the extent of applicability of ASME Code AG-1 to the specific equipment, description of the equipment, conformance, testing, and design required. The paper also discusses the problems encountered in implementing ASME AG-1, working around Code sections that were not complete at contract inception, conflicts in project documents and related problems. Also discussed are the logistics problems, material availability, and quality assurance aspects complicating the applications of ASME AG-1, due to the required Korean content for some components. Based on successfully supplying the equipment referenced above, it has been concluded that AG-1 is a working document and can be successfully implemented. It provides the requirements necessary for performance, design, construction, acceptance testing, and quality assurance of equipment used as components in nuclear air and gas treatment systems in nuclear facilities. The paper also addresses lessons learned and aspects of mixing US design and US built components in Korean built assemblies

  11. FY16 ASME High Temperature Code Activities

    Energy Technology Data Exchange (ETDEWEB)

    Swindeman, M. J. [Chromtech Inc., Oak Ridge, TN (United States); Jetter, R. I. [R. I Jetter Consulting, Pebble Beach, CA (United States); Sham, T. -L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-09-01

    One of the objectives of the ASME high temperature Code activities is to develop and validate both improvements and the basic features of Section III, Division 5, Subsection HB, Subpart B (HBB). The overall scope of this task is to develop a computer program to be used to assess whether or not a specific component under specified loading conditions will satisfy the elevated temperature design requirements for Class A components in Section III, Division 5, Subsection HB, Subpart B (HBB). There are many features and alternative paths of varying complexity in HBB. The initial focus of this task is a basic path through the various options for a single reference material, 316H stainless steel. However, the program will be structured for eventual incorporation all the features and permitted materials of HBB. Since this task has recently been initiated, this report focuses on the description of the initial path forward and an overall description of the approach to computer program development.

  12. Proceedings of the ANS/ASME/NRC international topical meeting on nuclear reactor thermal-hydraulics: fundamental aspects of two-phase flow and boiling heat transfer

    International Nuclear Information System (INIS)

    1980-08-01

    Separate abstracts are included for each of the papers presented concerning critical flow of two-phase mixtures; two-phase flow instrumentation; critical heat flux and effects of local disturbances; heat transfer and rewetting during reflood; hydrodynamic mechanisms in boiling heat transfer; and entrainment and droplet deposition in two-phase flow. Five papers have been previously abstracted and input to the data base

  13. ASME Code requirements for multi-canister overpack design and fabrication

    International Nuclear Information System (INIS)

    SMITH, K.E.

    1998-01-01

    The baseline requirements for the design and fabrication of the MCO include the application of the technical requirements of the ASME Code, Section III, Subsection NB for containment and Section III, Subsection NG for criticality control. ASME Code administrative requirements, which have not historically been applied at the Hanford site and which have not been required by the US Nuclear Regulatory Commission (NRC) for licensed spent fuel casks/canisters, were not invoked for the MCO. As a result of recommendations made from an ASME Code consultant in response to DNFSB staff concerns regarding ASME Code application, the SNF Project will be making the following modifications: issue an ASME Code Design Specification and Design Report, certified by a Registered Professional Engineer; Require the MCO fabricator to hold ASME Section III or Section VIII, Division 2 accreditation; and Use ASME Authorized Inspectors for MCO fabrication. Incorporation of these modifications will ensure that the MCO is designed and fabricated in accordance with the ASME Code. Code Stamping has not been a requirement at the Hanford site, nor for NRC licensed spent fuel casks/canisters, but will be considered if determined to be economically justified

  14. Effect of soil temperature on optical frequency transfer through unidirectional dense-wavelength-division-multiplexing fiber-optic links

    NARCIS (Netherlands)

    Pinkert, T.J.; Boll, O.; Willmann, L.; Jansen, G.S.M.; Dijck, E.A.; Groeneveld, B.G.H.M.; Smets, R.; Bosveld, F.C.; Ubachs, W.M.G.; Jungmann, K.; Eikema, K.S.E.; Koelemeij, J.C.J.

    2015-01-01

    Results of optical frequency transfer over a carrier-grade dense-wavelength-division-multiplexing (DWDM) optical fiber network are presented. The relation between soil temperature changes on a buried optical fiber and frequency changes of an optical carrier through the fiber is modeled. Soil

  15. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2010-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  16. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2011-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  17. ASME Code Efforts Supporting HTGRs

    Energy Technology Data Exchange (ETDEWEB)

    D.K. Morton

    2012-09-01

    In 1999, an international collaborative initiative for the development of advanced (Generation IV) reactors was started. The idea behind this effort was to bring nuclear energy closer to the needs of sustainability, to increase proliferation resistance, and to support concepts able to produce energy (both electricity and process heat) at competitive costs. The U.S. Department of Energy has supported this effort by pursuing the development of the Next Generation Nuclear Plant, a high temperature gas-cooled reactor. This support has included research and development of pertinent data, initial regulatory discussions, and engineering support of various codes and standards development. This report discusses the various applicable American Society of Mechanical Engineers (ASME) codes and standards that are being developed to support these high temperature gascooled reactors during construction and operation. ASME is aggressively pursuing these codes and standards to support an international effort to build the next generation of advanced reactors so that all can benefit.

  18. Analysis of preservice inspection relief requests and recommendations for ASME code changes

    International Nuclear Information System (INIS)

    Cook, J.F.

    1985-05-01

    NRC regulations require that preservice inspection (PSI) of nuclear plants be performed in accordance with referenced editions and addenda of Division 1 rules of Section XI, ''Rules for Inservice Inspection of Nuclear Power Plant Components'', of the ASME Boiler and Pressure Vessel Code (ASME Code). The regulations permit applicants to request and obtain relief from the NRC from specific ASME Code requirements that are determined to be impractical. Applicant requests for relief from preservice inspection (PSI) requirements were compiled and analyzed. From this data, covering a total of 178 relief requests, common problems with examination requirements were identified. Changes to examination requirements to solve selected problems are proposed. By following later ASME Code requirements, 46 out of the 178 relief requests can be eliminated. Implementing proposed Code changes would eliminate another 25 relief requests, leaving 107 relief requests out of the original 178 relief requests covered by this survey

  19. 77 FR 3073 - American Society of Mechanical Engineers (ASME) Codes and New and Revised ASME Code Cases...

    Science.gov (United States)

    2012-01-23

    ...-AI35 American Society of Mechanical Engineers (ASME) Codes and New and Revised ASME Code Cases... addenda to the ASME Boiler and Pressure Vessel (B&PV) Code, and the ASME Code for Operation and... on their use) ASME B&PV Code Cases N-722-1 and N-770-1. This document is necessary to correct...

  20. Rethinking ASME III seismic analysis for piping operability evaluations

    International Nuclear Information System (INIS)

    Adams, T.M.; Stevenson, J.D.

    1994-01-01

    It has been recognized since the mid 1980's that there are very large seismic margins to failure for nuclear piping systems when designed using current industry practice, design criteria, and methods. As a result of this realization there are or have been approximately eighteen initiatives within the ASME , Boiler and Pressure Vessel Code Section III, Division 1, in the form of proposed code cases and proposed code text changes designed to reduce these failure margins to more realistic values. For the most part these initiatives have concentrated on reclassifying seismic inertia stresses in the piping as secondary and increasing the allowable stress limits permitted by Section III of the ASME, Boiler Code. This paper focuses on the application of non-linear spectral analysis methods as a method to reduce the input seismic demand determination and thereby reduce the seismic failure margins. The approach is evaluated using the ASME Boiler Pressure Vessel Code Section III Subgroup on Design benchmark procedure as proposed by the Subgroup's Special Task Group on Integrated Piping Criteria. Using this procedure, criteria are compared to current code criterion and analysis methods, and several other of the currently proposed Boiler and Pressure Vessel, Section III, changes. Finally, the applicability of the non-linear spectral analysis to continued Safe Operation Evaluations is reviewed and discussed

  1. Globalization of ASME Nuclear Codes and Standards

    International Nuclear Information System (INIS)

    Swayne, Rick; Erler, Bryan A.

    2006-01-01

    With the globalization of the nuclear industry, it is clear that the reactor suppliers are based in many countries around the world (such as United States, France, Japan, Canada, South Korea, South Africa) and they will be marketing their reactors to many countries around the world (such as US, China, South Korea, France, Canada, Finland, Taiwan). They will also be fabricating their components in many different countries around the world. With this situation, it is clear that the requirements of ASME Nuclear Codes and Standards need to be adjusted to accommodate the regulations, fabricating processes, and technology of various countries around the world. It is also very important for the American Society of Mechanical Engineers (ASME) to be able to assure that products meeting the applicable ASME Code requirements will provide the same level of safety and quality assurance as those products currently fabricated under the ASME accreditation process. To do this, many countries are in the process of establishing or changing their regulations, and it is important for ASME to interface with the appropriate organizations in those countries, in order to ensure there is effective use of ASME Codes and standards around the world. (authors)

  2. Effect of soil temperature on optical frequency transfer through unidirectional dense-wavelength-division-multiplexing fiber-optic links.

    Science.gov (United States)

    Pinkert, T J; Böll, O; Willmann, L; Jansen, G S M; Dijck, E A; Groeneveld, B G H M; Smets, R; Bosveld, F C; Ubachs, W; Jungmann, K; Eikema, K S E; Koelemeij, J C J

    2015-02-01

    Results of optical frequency transfer over a carrier-grade dense-wavelength-division-multiplexing (DWDM) optical fiber network are presented. The relation between soil temperature changes on a buried optical fiber and frequency changes of an optical carrier through the fiber is modeled. Soil temperatures, measured at various depths by the Royal Netherlands Meteorology Institute (KNMI) are compared with observed frequency variations through this model. A comparison of a nine-day record of optical frequency measurements through the 2×298  km fiber link with soil temperature data shows qualitative agreement. A soil temperature model is used to predict the link stability over longer periods (days-months-years). We show that optical frequency dissemination is sufficiently stable to distribute and compare, e.g., rubidium frequency standards over standard DWDM optical fiber networks using unidirectional fibers.

  3. International Accreditation of ASME Codes and Standards

    International Nuclear Information System (INIS)

    Green, Mervin R.

    1989-01-01

    ASME established a Boiler Code Committee to develop rules for the design, fabrication and inspection of boilers. This year we recognize 75 years of that Code and will publish a history of that 75 years. The first Code and subsequent editions provided for a Code Symbol Stamp or mark which could be affixed by a manufacturer to a newly constructed product to certify that the manufacturer had designed, fabricated and had inspected it in accordance with Code requirements. The purpose of the ASME Mark is to identify those boilers that meet ASME Boiler and Pressure Vessel Code requirements. Through thousands of updates over the years, the Code has been revised to reflect technological advances and changing safety needs. Its scope has been broadened from boilers to include pressure vessels, nuclear components and systems. Proposed revisions to the Code are published for public review and comment four times per year and revisions and interpretations are published annually; it's a living and constantly evolving Code. You and your organizations are a vital part of the feedback system that keeps the Code alive. Because of this dynamic Code, we no longer have columns in newspapers listing boiler explosions. Nevertheless, it has been argued recently that ASME should go further in internationalizing its Code. Specifically, representatives of several countries, have suggested that ASME delegate to them responsibility for Code implementation within their national boundaries. The question is, thus, posed: Has the time come to franchise responsibility for administration of ASME's Code accreditation programs to foreign entities or, perhaps, 'institutes.' And if so, how should this be accomplished?

  4. Improvement of ASME NH for Grade 91

    Energy Technology Data Exchange (ETDEWEB)

    Bernard Riou

    2007-10-09

    This report has been prepared in the context of Task 3 of the ASME/DOE Gen IV material project. It has been identified that creep-fatigue evaluation procedures presently available in ASME (1) and RCC-MR (2) have been mainly developed for austenitic stainless steels and may not be suitable for cyclic softening materials such as mod 9 Cr 1 Mo steel (grade 91). The aim of this document is, starting from experimental test results, to perform a review of the procedures and, if necessary, provide recommendations for their improvements.

  5. ASME Based Quality Documentation Guidelines for Power- and Recovery Boilers

    OpenAIRE

    Lappalainen, Tuomas

    2015-01-01

    The goal of this thesis was to create ASME-based quality documentation guidelines for power- and recovery boilers. The client was a large international power- and recovery boiler manufacturer. The content of this thesis is mainly a report of ASME code and its effects on quality documentation. In thesis are widely compared ASME based quality documention differences between PED/EN projects quality documentation. Also ASMEs most important elements for power- and recovery boiler projects needs fo...

  6. Activated sludge model No. 2d, ASM2d

    DEFF Research Database (Denmark)

    Henze, M.

    1999-01-01

    The Activated Sludge Model No. 2d (ASM2d) presents a model for biological phosphorus removal with simultaneous nitrification-denitrification in activated sludge systems. ASM2d is based on ASM2 and is expanded to include the denitrifying activity of the phosphorus accumulating organisms (PAOs......). This extension of ASM2 allows for improved modeling of the processes, especially with respect to the dynamics of nitrate and phosphate. (C) 1999 IAWQ Published by Elsevier Science Ltd. All rights reserved....

  7. Nupack, the new ASME code for radioactive material transportation packaging containments

    International Nuclear Information System (INIS)

    Turula, P.

    1998-01-01

    The American Society of Mechanical Engineers (ASME) has added a new division to the nuclear construction section of its Boiler and Pressure Vessel Code (B and PVC). This Division, commonly referred to as Nupack, has been written to provide a consistent set of technical requirements for containment vessels of transportation packagings for high-level radioactive materials. This paper provides an introduction to Nupack, discusses some of its technical provisions, and describes how it can be used for the design and construction of packaging components. Nupack's general provisions and design requirements are emphasized, while treatment of materials, fabrication and inspection is left for another paper

  8. 78 FR 37848 - ASME Code Cases Not Approved for Use

    Science.gov (United States)

    2013-06-24

    ... COMMISSION ASME Code Cases Not Approved for Use AGENCY: Nuclear Regulatory Commission. ACTION: Draft... public comment draft regulatory guide (DG), DG-1233, ``ASME Code Cases not Approved for Use.'' This regulatory guide lists the American Society of Mechanical Engineers (ASME) Code Cases that the NRC has...

  9. Proceedings: 2000 ASME/EPRI Radwaste Workshop

    International Nuclear Information System (INIS)

    2001-01-01

    Nuclear utilities are continually evaluating methods to improve operations and reduce costs associated with radioactive waste management. The continuing deregulation process has added increased emphasis to this activity. The Annual ASME/EPRI Workshop facilitates this effort by communicating technological and managerial improvements throughout the industry. This workshop, restricted to utility radwaste professionals, also serves to communicate practical in-plant improvements with the opportunity to discuss them in detail

  10. Proceedings: 2001 ASME/EPRI Radwaste Workshop

    International Nuclear Information System (INIS)

    2001-01-01

    Nuclear utilities continually evaluate methods to improve operations and reduce costs associated with radioactive waste management. The continuing deregulation process has increased the emphasis on this activity. The Annual ASME/EPRI Workshop facilitates this effort by communicating technology and management improvements throughout the industry. This workshop, restricted to utility radwaste professionals, also serves to communicate practical in-plant improvements with the opportunity to discuss them in detail

  11. Temporal Deductive Verification of Basic ASM Models

    OpenAIRE

    Daho, Hocine El-Habib; University of Oran; Benhamamouch, Djillali; University of Oran

    2010-01-01

    Abstract State Machines (ASMs, for short) provide a practical new computational model which has been applied in the area of software engineering for systems design and analysis. However, reasoning about ASM models occurs, not within a formal deductive system, but basically in the classical informal proofs style of mathematics. Several formal verification approaches for proving correctness of ASM models have been investigated. In this paper we consider the use of the TLA+logic for the deductive...

  12. Application of the ASME code in designing containment vessels for packages used to transport radioactive materials

    International Nuclear Information System (INIS)

    Raske, D.T.; Wang, Z.

    1992-01-01

    The primary concern governing the design of shipping packages containing radioactive materials is public safety during transport. When these shipments are within the regulatory jurisdiction of the US Department of Energy, the recommended design criterion for the primary containment vessel is either Section III or Section VIII, Division 1, of the ASME Boiler and Pressure Vessel Code, depending on the activity of the contents. The objective of this paper is to discuss the design of a prototypic containment vessel representative of a packaging for the transport of high-level radioactive material

  13. Draft ASME code case on ductile cast iron for transport packaging

    Energy Technology Data Exchange (ETDEWEB)

    Saegusa, T. [Central Research Inst. of Electric Power Industry, Abiko (Japan); Arai, T. [Central Research Inst. of Electric Power Industry, Yokosuka (Japan); Hirose, M. [Nuclear Fuel Transport Co., Ltd., Tokyo (Japan); Kobayashi, T. [Nippon Chuzo, Kawasaki (Japan); Tezuka, Y. [Mitsubishi Materials Co., Tokyo (Japan); Urabe, N. [Kokan Keisoku K. K., Kawasaki (Japan); Hueggenberg, R. [GNB, Essen (Germany)

    2004-07-01

    The current Rules for Construction of ''Containment Systems for Storage and Transport Packagings of Spent Nuclear Fuel and High Level Radioactive Material and Waste'' of Division 3 in Section III of ASME Code (2001 Edition) does not include ductile cast iron in its list of materials permitted for use. The Rules specify required fracture toughness values of ferritic steel material for nominal wall thickness 5/8 to 12 inches (16 to 305 mm). New rule for ductile cast iron for transport packaging of which wall thickness is greater than 12 inches (305mm) is required.

  14. AsmL Specification of a Ptolemy II Scheduler

    DEFF Research Database (Denmark)

    Lázaro Cuadrado, Daniel; Koch, Peter; Ravn, Anders Peter

    2003-01-01

    Ptolemy II is a tool that combines different computational models for simulation and design of embedded systems. AsmL is a software specification language based on the Abstract State Machine formalism. This paper reports on development of an AsmL model of the Synchronous Dataflow domain scheduler...

  15. Nupack, the new Asme code for radioactive material transportation packaging containments

    International Nuclear Information System (INIS)

    Turula, P.

    1998-01-01

    The American Society of Mechanical Engineers (ASME) has added a new division to the nuclear construction section of its Boiler and Pressure Vessel Code (B and PVC). This Division, commonly referred to as 'Nupack', has been written to provide a consistent set of technical requirements for containment vessels of transportation packagings for high-level radioactive materials. This paper provides an introduction to Nupack, discusses some of its technical provisions, and describes how it can be used the design and construction of packaging components. Nupack's general provisions and design requirements are emphasized, while treatment of materials, fabrication and inspection is left for another paper. Participation in the Nupack development work described in this paper was supported by the U.S. Department of Energy. (authors)

  16. 1985 ASME-EPRI radwaste workshop: proceedings

    International Nuclear Information System (INIS)

    Coplan, B.V.

    1985-07-01

    The proceedings of the seventh ASME/EPRI jointly sponsored radwaste workshop are presented. The workshop presentations and discussion sessions addressed the following pertinent issues: Meeting Radwaste Regulatory Requirements; Mobile Services; and Radwaste Equipment and Reducing Costs. Interest in meeting regulatory requirements centered on the various aspects of 10CFR61. Proper sampling, compliance methodology, hydrogen generation in stored radwaste and process control programs were the major topics of discussion. Use of mobile services provided by outside organizations is increasing. An extensive summary of available mobile services was presented in the areas of radwaste processing, solidification and decontamination, as well as information on special on-site storage containers. Under the areas of radwaste equipment and reducing costs, the principal items were the status of a mobile incinerator for Commonwealth Edison, establishment of a deminimis level for waste at Ginna, resin volume reduction at Brunswick and a dry active waste segregation program at TVA. Presentations were also made on radwaste transportation and burial and on two planned regional radwaste incineration facilities. The meeting concluded with an open discussion period for all participants on a variety of radwaste items

  17. Auriculoterapia en pacientes asmáticos

    Directory of Open Access Journals (Sweden)

    Adolfo González Salvador

    1997-04-01

    Full Text Available Se realiza un estudio para evaluar la eficacia de la auriculopuntura en 30 asmáticos del área de salud de Aguada de Pasajeros, durante los meses de noviembre de 1992 a abril de 1993. El tratamiento se aplicó durante un mes, con seguimiento durante los 5 meses posteriores. Se observó una disminución en la frecuencia, intensidad y duración de las crisis de asma; la mayoría de los pacientes tuvo una evolución satisfactoria y no se presentaron complicaciones. Se concluye que la auriculoterapia es un método útil en pacientes con asma bronquial debido a su eficacia e inocuidadA study was conducted to evaluate the efficacy of auriculopuncture in 30 asthmatic patients from the health area of Aguada de Pasajeros between November, 1992, and April, 1993. The treatment was applied for a month, with a follow-up during the next 5 months. It was observed a reduction in the frequency, intensity and duration of the asthma crises. Most of the patients had a satisfactory evolution and there were no complications. It is concluded that auriculotherapy is a useful method for patients with bronchial asthma due to its effectiveness and innocuousness.

  18. An example of a component replacement when applying ASME N509 and ASME N510 to older ventilation systems

    Energy Technology Data Exchange (ETDEWEB)

    Arndt, T.E. [Westinghouse Hanford Company, Richland, WA (United States)

    1995-02-01

    This paper presents an example of a component replacement (electric heater) when installed in an older ventilation system that was constructed before the issuance of ASME N509{sup 1} and N510{sup 2}. Many of the existing ventilation systems at the Hanford Site were designed, fabricated, and installed before the issuance of ASME N509{sup 1} and N510{sup 2}. Requiring the application of these codes to existing ventilation systems presents challenges to the engineer when design changes are needed. Although it may seem that the application of ASME N509{sup 1} or N510{sup 2} may be a hindrance at times, this does not need to occur. Proper preparation at the start of project or design modifications can minimize frustration to the engineer when it is judged that portions of ASME N509{sup 1} and N510{sup 2} do not apply in a particular application.

  19. ASME nuclear codes and standards risk management strategic planning

    International Nuclear Information System (INIS)

    Hill, Ralph S. III; Balkey, Kenneth R.; Erler, Bryan A.; Wesley Rowley, C.

    2007-01-01

    This paper is prepared in honor and in memory of the late Professor Emeritus Yasuhide Asada to recognize his contributions to ASME Nuclear Codes and Standards initiatives, particularly those related to risk-informed technology and System Based Code developments. For nearly two decades, numerous risk-informed initiatives have been completed or are under development within the ASME Nuclear Codes and Standards organization. In order to properly manage the numerous initiatives currently underway or planned for the future, the ASME Board on Nuclear Codes and Standards (BNCS) has an established Risk Management Strategic Plan (Plan) that is maintained and updated by the ASME BNCS Risk Management Task Group. This paper presents the latest approved version of the plan beginning with a background of applications completed to date, including the recent probabilistic risk assessment (PRA) standards developments for nuclear power plant applications. The paper discusses planned applications within ASME Nuclear Codes and Standards that will require expansion of the ASME PRA Standard to support new advanced light water reactor and next generation reactor developments, such as for high temperature gas-cooled reactors. Emerging regulatory developments related to risk-informed, performance- based approaches are summarized. A long-term vision for the potential development and evolution to a nuclear systems code that adopts a risk-informed approach across a facility life-cycle (design, construction, operation, maintenance, and closure) is also summarized. Finally, near term and long term actions are defined across the ASME Nuclear Codes and Standards organizations related to risk management, including related U.S. regulatory activities. (author)

  20. ASME Section VIII Recertification of a 33,000 Gallon Vacuum-jacketed LH2 Storage Vessel for Densified Hydrogen Testing at NASA Kennedy Space Center

    Science.gov (United States)

    Swanger, Adam M.; Notardonato, William U.; Jumper, Kevin M.

    2015-01-01

    The Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) has been developed at NASA Kennedy Space Center in Florida. GODU-LH2 has three main objectives: zero-loss storage and transfer, liquefaction, and densification of liquid hydrogen. A cryogenic refrigerator has been integrated into an existing, previously certified, 33,000 gallon vacuum-jacketed storage vessel built by Minnesota Valley Engineering in 1991 for the Titan program. The dewar has an inner diameter of 9.5 and a length of 71.5; original design temperature and pressure ranges are -423 F to 100 F and 0 to 95 psig respectively. During densification operations the liquid temperature will be decreased below the normal boiling point by the refrigerator, and consequently the pressure inside the inner vessel will be sub-atmospheric. These new operational conditions rendered the original certification invalid, so an effort was undertaken to recertify the tank to the new pressure and temperature requirements (-12.7 to 95 psig and -433 F to 100 F respectively) per ASME Boiler and Pressure Vessel Code, Section VIII, Division 1. This paper will discuss the unique design, analysis and implementation issues encountered during the vessel recertification process.

  1. ASME code considerations for the compact heat exchanger

    Energy Technology Data Exchange (ETDEWEB)

    Nestell, James [MPR Associates Inc., Alexandria, VA (United States); Sham, Sam [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-08-31

    The mission of the U.S. Department of Energy (DOE), Office of Nuclear Energy is to advance nuclear power in order to meet the nation's energy, environmental, and energy security needs. Advanced high temperature reactor systems such as sodium fast reactors and high and very high temperature gas-cooled reactors are being considered for the next generation of nuclear reactor plant designs. The coolants for these high temperature reactor systems include liquid sodium and helium gas. Supercritical carbon dioxide (sCO₂), a fluid at a temperature and pressure above the supercritical point of CO₂, is currently being investigated by DOE as a working fluid for a nuclear or fossil-heated recompression closed Brayton cycle energy conversion system that operates at 550°C (1022°F) at 200 bar (2900 psi). Higher operating temperatures are envisioned in future developments. All of these design concepts require a highly effective heat exchanger that transfers heat from the nuclear or chemical reactor to the chemical process fluid or the to the power cycle. In the nuclear designs described above, heat is transferred from the primary to the secondary loop via an intermediate heat exchanger (IHX) and then from the intermediate loop to either a working process or a power cycle via a secondary heat exchanger (SHX). The IHX is a component in the primary coolant loop which will be classified as "safety related." The intermediate loop will likely be classified as "not safety related but important to safety." These safety classifications have a direct bearing on heat exchanger design approaches for the IHX and SHX. The very high temperatures being considered for the VHTR will require the use of very high temperature alloys for the IHX and SHX. Material cost considerations alone will dictate that the IHX and SHX be highly effective; that is, provide high heat transfer area in a small volume. This feature must be accompanied by low pressure drop and mechanical reliability and

  2. Comparison between ASME and ISO standards on surface texture

    Science.gov (United States)

    Hu, Kai; Jiang, Xiangqian; Liu, Xiaojun; Xu, Zhengao

    2006-11-01

    Surface texture is generally a significant technique requirement of high-tech products. Surface quality information can usually play an increasing role in achieving interoperability among existing products, create order in markets, simplify production and ensure safety. As the most authoritative standard organizations, ASME and ISO services are used throughout the world, their codes and standards influence global manufacturers and consumers. ASME B46.1 is one of many vital tools to promote surface measurement techniques, while ISO has a set standard system for surface measurement, analysis and evaluation. This paper compares the ASME B46.1 (2002) standard (Surface texture: surface roughness, waviness, and lay) with ISO 3274 (1997) standard on methods of surface profiles filtering. It preformed the present research in order to show the latest developments of the ASME B46.1 (2002) in the regime of contact profiling techniques where the degree of measurement control is highly advanced, and a large range of other techniques that present valid and useful descriptions of surface texture. Also, this paper shows the differences of terms, definitions and surface texture parameters between ASME B46.1 (2002) and ISO 4287 (1998). The different evaluation results have been calculated based on above two standards for the same surface data. Obviously, it is necessary to consider the divergence above to develop China's standards (GB) on surface texture.

  3. Penetration of ASM 981 in canine skin: a comparative study.

    Science.gov (United States)

    Gutzwiller, Meret E Ricklin; Reist, Martin; Persohn, Elke; Peel, John E; Roosje, Petra J

    2006-01-01

    ASM 981 has been developed for topical treatment of inflammatory skin diseases. It specifically inhibits the production and release of pro-inflammatory cytokines. We measured the skin penetration of ASM 981 in canine skin and compared penetration in living and frozen skin. To make penetration of ASM 981 visible in dog skin, tritium labelled ASM 981 was applied to a living dog and to defrosted skin of the same dog. Using qualitative autoradiography the radioactive molecules were detected in the lumen of the hair follicles until the infundibulum, around the superficial parts of the hair follicles and into a depth of the dermis of 200 to 500 microm. Activity could not be found in deeper parts of the hair follicles, the dermis or in the sebaceous glands. Penetration of ASM 981 is low in canine skin and is only equally spread in the upper third of the dermis 24 hours after application. Penetration in frozen skin takes even longer than in living canine skin but shows the same distribution.

  4. Index to place of publication of ASME Papers, 1978--1988

    International Nuclear Information System (INIS)

    Youngen, G.K.

    1990-06-01

    This index is a list of American Society of Mechanical Engineers (ASME) Papers that are reprinted in the ASME Transactions series of journals. ASME Papers are often cited only by their paper number, making it difficult to determine if the article has ever appeared in print in the journal literature. This index will be useful for tracking down those papers published as journal articles by the ASME. It will also serve as a guide for retention for subscribers to the ASME Papers and Transaction Series. Paper numbers that appear in the journals may be weeded from the collection of ASME Papers

  5. Flanged joints with contact outside the bolt circle: ASME Part B design rules

    International Nuclear Information System (INIS)

    Rodabaugh, E.C.; Moore, S.E.

    1976-05-01

    The ASME Boiler and Pressure Vessel Code, Section VIII, Division 1, gives rules which are subdivided into ''Part A'' and ''Part B''. Part A covers flanged joints where contact between flanges occurs through a gasket located inside the bolt holes. Part B covers flanged joints with contact outside the bolt holes. This report (a) summarizes the theory for Part B flanged joints, (b) presents examples which show the significant differences between Part A flanged joints and Part B flanged joints, (c) presents the available test data relevant to the characteristics of Part B flanged joints, (d) gives listings of two computer programs which can be used to evaluate the characteristics of Part B flanged joints, and (e) gives recommendations for Code revisions and other aspects of Part B flanged-joint design

  6. Comparative study of design of piping supports class 1, 2 and 3 considering german code KTA and ASME III - NF

    International Nuclear Information System (INIS)

    Faloppa, Altair A.; Fainer, Gerson; Mattar Neto, Miguel; Elias, Marcos V.

    2013-01-01

    The objective of this paper is developing a comparative study of the design criteria for class 1, 2, 3 piping supports considering the American Code ASME Section III - NF and the German Code KTA 3205.1 to the Primary Circuit, KTA 3205.2 to the others systems and KTA 3205.3 series-production standards supports of a PWR nuclear power plant. An additional purpose of the paper is a general analysis of the main design concepts of the American Code ASME Boiler and Pressure Vessel Code, Section III, Division 1 and German Nuclear Design Code KTA that was performed in order to aid the comparative study proposed. The relevance of this study is to show the differences between codes ASME and KTA since they were applied in the design of the Nuclear Power Plants Angra 1 and Angra 2, and to the design of Angra 3, which is at the moment under construction. It is also considered their use in the design of nuclear installations such as RMB - Reator MultiProposito Brasileiro and LABGENE - Laboratorio de Geracao Nucleoeletrica. (author)

  7. Inservice inspection procedures and training according to the ASME code

    International Nuclear Information System (INIS)

    Greenwald, S.M.; Chockie, L.J.

    1987-01-01

    Mandatory training of the technical staff at a nuclear power plant is of paramount importance if we are to avoid costly plant shutdowns. This training should include the requirements for both Preservice and Inservice Inspection, in addition to Quality Assurance procedures as required by the American Society of Mechanical Engineers (ASME) Code. The training is best accomplished by utilizing instructors who are thoroughly familiar with plant operations and the ASME Code, as well as serving on one of the Code committees. This paper focuses on the Inservice Inspection procedures and the results of an intensive training effort to implement such procedures. (author)

  8. Inservice inspection procedures and training according to the ASME code

    Energy Technology Data Exchange (ETDEWEB)

    Greenwald, S.M.; Chockie, L.J.

    1988-01-01

    Mandatory training of the technical staff at a nuclear power plant is of paramount importance if we are to avoid costly plant shutdowns. This training should include the requirements for both Preservice and inservice Inspection, in addition to Quality Assurance procedures as required by the American Society of Mechanical Engineers (ASME) Code. The training is best accomplished by utilizing instructors who are thoroughly familiar with plant operations and the ASME Code, as well as serving on one of the code committees. This paper focuses on the Inservice Inspection procedures and the results of an intensive training effort to implement such procedures.

  9. AsmL Specification of a Ptolemy II Scheduler

    DEFF Research Database (Denmark)

    Lázaro Cuadrado, Daniel; Koch, Peter; Ravn, Anders Peter

    2003-01-01

    Ptolemy II is a tool that combines different computational models for simulation and design of embedded systems. AsmL is a software specification language based on the Abstract State Machine formalism. This paper reports on development of an AsmL model of the Synchronous Dataflow domain scheduler...... of Ptolemy II. By building this model we can give precise semantics to the implementation. Furthermore it allows us to isolate the scheduling problem from the tool and make the potential parallelism of the implementation explicit. The model is executable and is tested against the implementation...

  10. The human ASM (adult skeletal muscle) gene: expression and chromosomal assignment to 11p15.

    Science.gov (United States)

    Leibovitch, M P; Nguyen, V C; Gross, M S; Solhonne, B; Leibovitch, S A; Bernheim, A

    1991-11-14

    A rat adult skeletal muscle probe (Asm15) originated from a rhabdomyosarcoma was used to isolate the human homologous sequence from a placenta cDNA library. Among several positive clones the longest EcoRI-EcoRI insert (ASM1) obtained was 1875 bp long with 72% homology with rat Asm15 cDNA sequence. Important variations of ASM1 RNA level were observed in different adult skeletal muscles. Expression of a 29kD ASM1 protein was demonstrated in human adult skeletal muscle lysates using an antiserum (PB1579) raised against the C terminal region of the rat Asm15 protein. The human ASM gene was assigned by somatic cell analysis with human (ASM1) and rat (Asm15) probes to chromosome 11, and by in situ hybridization with the human probe to 11p15, a chromosome region involved in human embryonal rhabdomyosarcomas. Except for the presence of a HindII restriction site, the results obtained for the restriction map and the sequence of ASM1 cDNA (data not shown) exhibited extensive homology with the human H19 DNA sequence which have been mapped with a mouse probe also in 11p15. This suggests that ASM/Asm and H19 may represent the same sequence (in this hypothesis the presence of the supplementary HindII site in our ASM1 probe is explained by polymorphic variability). However it was reported that human and mouse H19 mRNA did not encode for a protein but acted as an RNA molecule whereas in our present study ASM protein was detected in human adult skeletal muscle. This could be explained by important regulation of ASM protein expression during development and cell differentiation. However we cannot exclude for the different species studied (mouse, rat, and man) the hypothesis that H19 and ASM/Asm mRNA may represent two distinct messengers from the same gene or even from duplicated genes.

  11. 14 CFR 330.31 - What data must air carriers submit concerning ASMs or RTMs?

    Science.gov (United States)

    2010-01-01

    ... combination passenger/cargo carrier, you must have submitted your August 2001 total completed ASM report to... correct an error that you document to the Department, you must not alter the ASM or RTM reports you...

  12. Asm-1(+), a Neurospora Crassa Gene Related to Transcriptional Regulators of Fungal Development

    OpenAIRE

    Aramayo, R.; Peleg, Y.; Addison, R.; Metzenberg, R.

    1996-01-01

    This report describes the identification, cloning, and molecular analysis of Asm-1(+) (Ascospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1(+) gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1(+) (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd...

  13. Abelian Sandpile Model (ASM) and Infinite Volume Limit

    Indian Academy of Sciences (India)

    Self Organised Criticality (SOC). SOC- dynamics drive a system towards stationary state characterized by power law correlations in space and time. SOC- was proposed by [BTW 87,88] as a mechanism which could explain occurrence of fractal structures in diverse natural phenomena. ASM is a simple model where SOC ...

  14. ASM News Volume 71 Number 9, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Tamar Barkay and Barth F. Smets

    2005-01-01

    Genetic exchanges among prokaryotes, formerly considered only a marginal phenomenon, increasingly are being viewed as profoundly affecting evolution. Indeed, some researchers argue for utterly revamping our concept of microbial speciation and phylogeny by replacing the traditional ''tree'' with a newer ''net'' to account for these horizontal transfers of genes. This conceptual ferment is occurring while molecular biologists reveal how horizontal gene transfers occur even as microbes protect the integrity of their genomes. Other studies reveal the number and diversity and abundance of genetic elements that mediate horizontal gene transfers (HGTs) or facilitate genome rearrangements, deletions, and insertions. Taken together, this information suggests that microbial communities collectively possess a dynamic gene pool, where novel genetic combinations act as a driving force in genomic innovation, compensating individual microbial species for their inability to reproduce sexually. These microbial genomic dynamics can present both environmental threats and promise to humans. One major threat, for example, comes from the spread of antibiotic resistance and virulence genes among pathogenic microbes. Another less-documented issue involves transgenic plants and animals, whose uses are being restricted because of concerns that genes may be transferred to untargeted organisms where they might cause harm. A possible benefit from HGT comes from its potential to enhance the functional diversity of microbial communities and to improve their performance in changing or extreme environments. Such changes might be exploited, for example, as part of efforts to manage environmental pollution and might be achieved by spreading genes into resident microbes to confer specific biochemical activities.

  15. 46 CFR 57.02-2 - Adoption of section IX of the ASME Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section IX of the ASME Code. 57.02-2 Section... AND BRAZING General Requirements § 57.02-2 Adoption of section IX of the ASME Code. (a) The... accordance with section IX of the ASME (American Society of Mechanical Engineers) Code, as limited, modified...

  16. Evaluation of conservatisms and environmental effects in ASME Code, Section III, Class 1 fatigue analysis

    International Nuclear Information System (INIS)

    Deardorff, A.F.; Smith, J.K.

    1994-08-01

    This report documents the results of a study regarding the conservatisms in ASME Code Section 3, Class 1 component fatigue evaluations and the effects of Light Water Reactor (LWR) water environments on fatigue margins. After review of numerous Class 1 stress reports, it is apparent that there is a substantial amount of conservatism present in many existing component fatigue evaluations. With little effort, existing evaluations could be modified to reduce the overall predicted fatigue usage. Areas of conservatism include design transients considerably more severe than those experienced during service, conservative grouping of transients, conservatisms that have been removed in later editions of Section 3, bounding heat transfer and stress analysis, and use of the ''elastic-plastic penalty factor'' (K 3 ). Environmental effects were evaluated for two typical components that experience severe transient thermal cycling during service, based on both design transients and actual plant data. For all reasonable values of actual operating parameters, environmental effects reduced predicted margins, but fatigue usage was still bounded by the ASME Section 3 fatigue design curves. It was concluded that the potential increase in predicted fatigue usage due to environmental effects should be more than offset by decreases in predicted fatigue usage if re-analysis were conducted to reduce the conservatisms that are present in existing component fatigue evaluations

  17. ASME stress linearization and classification - a discussion based on a case study

    International Nuclear Information System (INIS)

    Miranda, Carlos A. de J.; Faloppa, Altair A.; Mattar Neto, Miguel; Fainer, Gerson

    2011-01-01

    The ASME code, specially in its Nuclear Division (Subsection NB - Class I Components), gives some recommendations to the structural analyst on how to perform the verifications required to prove the design as good as the by-analysis prevented failures modes. Each of these failure modes has specific stress limits which are established based on simple but conservative hypothesis like the material perfectly plastic behavior and the shell theory with its typical membrane and bending stresses with linear distribution along the thickness. Other detail to keep in mind is the code distinction between primary and secondary stresses (respectively, stress that came due to equilibrium and due to displacement compatibility). In general, the numerical models used in the analyses are developed with plane or 3D solid elements and due this fact no direct comparison with the code limits can be done and, besides that, the programs do not distinguish between primary and secondary stresses. Mostly, the later are produced due to the temperature variation but they also appear near discontinuities. Sometimes, this classification is not so clear or direct. To perform the required ASME Code verifications the analyst should obtain the membrane and bending stresses from the plane or 3-D model which is called stress linearization and, also, should classify them as primary and secondary. (The excess between the maximum stress at a point and the sum of these linearized values is called peak stress and is included in the fatigue verification.) This task, most of the time is not a simple one due to the nature of the involved load and/or the complex geometry under analysis. In fact, there are several studies discussing on how to perform these stress classification and linearization. The present paper shows a discussion on how to perform these verifications based on a generic geometry found in many plants, from petrochemical to nuclear, which emphasizes some of theses issues. (author)

  18. Bibliometric Analyses Reveal Patterns of Collaboration between ASMS Members

    Science.gov (United States)

    Palmblad, Magnus; van Eck, Nees Jan

    2018-01-01

    We have explored the collaborative network of the current American Society for Mass Spectrometry (ASMS) membership using bibliometric methods. The analysis shows that 4249 members are connected in a single, large, co-authorship graph, including the majority of the most published authors in the field of mass spectrometry. The map reveals topographical differences between university groups and national laboratories, and that the co-authors with the strongest links have long worked together at the same location. We have collected and summarized information on the geographical distribution of members, showing a high coverage of active researchers in North America and Western Europe. Looking at research fields, we could also identify a number of new or `hot' topics among ASMS members. Interactive versions of the maps are available on-line at https://goo.gl/UBNFMQ (collaborative network) and https://goo.gl/WV25vm (research topics).

  19. Bibliometric Analyses Reveal Patterns of Collaboration between ASMS Members.

    Science.gov (United States)

    Palmblad, Magnus; van Eck, Nees Jan

    2018-03-01

    We have explored the collaborative network of the current American Society for Mass Spectrometry (ASMS) membership using bibliometric methods. The analysis shows that 4249 members are connected in a single, large, co-authorship graph, including the majority of the most published authors in the field of mass spectrometry. The map reveals topographical differences between university groups and national laboratories, and that the co-authors with the strongest links have long worked together at the same location. We have collected and summarized information on the geographical distribution of members, showing a high coverage of active researchers in North America and Western Europe. Looking at research fields, we could also identify a number of new or 'hot' topics among ASMS members. Interactive versions of the maps are available on-line at https://goo.gl/UBNFMQ (collaborative network) and https://goo.gl/WV25vm (research topics). Graphical Abstract ᅟ.

  20. Bibliometric Analyses Reveal Patterns of Collaboration between ASMS Members

    Science.gov (United States)

    Palmblad, Magnus; van Eck, Nees Jan

    2018-03-01

    We have explored the collaborative network of the current American Society for Mass Spectrometry (ASMS) membership using bibliometric methods. The analysis shows that 4249 members are connected in a single, large, co-authorship graph, including the majority of the most published authors in the field of mass spectrometry. The map reveals topographical differences between university groups and national laboratories, and that the co-authors with the strongest links have long worked together at the same location. We have collected and summarized information on the geographical distribution of members, showing a high coverage of active researchers in North America and Western Europe. Looking at research fields, we could also identify a number of new or `hot' topics among ASMS members. Interactive versions of the maps are available on-line at https://goo.gl/UBNFMQ (collaborative network) and https://goo.gl/WV25vm (research topics). [Figure not available: see fulltext.

  1. Activated sludge model (ASM) based modelling of membrane bioreactor (MBR) processes: a critical review with special regard to MBR specificities.

    Science.gov (United States)

    Fenu, A; Guglielmi, G; Jimenez, J; Spèrandio, M; Saroj, D; Lesjean, B; Brepols, C; Thoeye, C; Nopens, I

    2010-08-01

    Membrane bioreactors (MBRs) have been increasingly employed for municipal and industrial wastewater treatment in the last decade. The efforts for modelling of such wastewater treatment systems have always targeted either the biological processes (treatment quality target) as well as the various aspects of engineering (cost effective design and operation). The development of Activated Sludge Models (ASM) was an important evolution in the modelling of Conventional Activated Sludge (CAS) processes and their use is now very well established. However, although they were initially developed to describe CAS processes, they have simply been transferred and applied to MBR processes. Recent studies on MBR biological processes have reported several crucial specificities: medium to very high sludge retention times, high mixed liquor concentration, accumulation of soluble microbial products (SMP) rejected by the membrane filtration step, and high aeration rates for scouring purposes. These aspects raise the question as to what extent the ASM framework is applicable to MBR processes. Several studies highlighting some of the aforementioned issues are scattered through the literature. Hence, through a concise and structured overview of the past developments and current state-of-the-art in biological modelling of MBR, this review explores ASM-based modelling applied to MBR processes. The work aims to synthesize previous studies and differentiates between unmodified and modified applications of ASM to MBR. Particular emphasis is placed on influent fractionation, biokinetics, and soluble microbial products (SMPs)/exo-polymeric substances (EPS) modelling, and suggestions are put forward as to good modelling practice with regard to MBR modelling both for end-users and academia. A last section highlights shortcomings and future needs for improved biological modelling of MBR processes. (c) 2010 Elsevier Ltd. All rights reserved.

  2. Investigating ASME allowable loads with finite element analyses

    International Nuclear Information System (INIS)

    Mattar Neto, Miguel; Bezerra, Luciano M.; Miranda, Carlos A. de J.; Cruz, Julio R.B.

    1995-01-01

    The evaluation of nuclear components using finite element analysis (FEA) does not generally fall into the shell type verification adopted by the ASME Code. Consequently, the demonstration that the modes of failure are avoided sometimes is not straightforward. Allowable limits, developed by limit load theory, require the computation of shell membrane and bending stresses. How to calculate these stresses from FEA is not necessarily self-evident. One approach to be considered is to develop recommendations in a case-by-case basis for the most common pressure vessel geometries and loads based on comparison between the results of elastic and plastic FEA. In this paper, FE analyses of common 2D and complex 3D geometries are examined and discussed. It will be clear that in the cases studied, stress separation and categorization are not self-evident and simple tasks to undertake. Certain unclear recommendations of ASME Code can lead the stress analyst to non conservative designs as will be demonstrated in this paper. At the endo of this paper, taking into account comparison between elastic and elastic-plastic FE results from ANSYS some observations, suggestions and conclusions about the degree of conservatism of the ASME recommendations will be addressed. (author)

  3. Design Procedure of Graphite Components by ASME HTR Codes

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Ji-Ho; Jo, Chang Keun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    In this study, the ASME B and PV Code, Subsection HH, Subpart A, design procedure for graphite components of HTRs was reviewed and the differences from metal materials were remarked. The Korean VHTR has a prismatic core which is made of multiple graphite blocks, reflectors, and core supports. One of the design issues is the assessment of the structural integrity of the graphite components because the graphite is brittle and shows quite different behaviors from metals in high temperature environment. The American Society of Mechanical Engineers (ASME) issued the latest edition of the code for the high temperature reactors (HTR) in 2015. In this study, the ASME B and PV Code, Subsection HH, Subpart A, Graphite Materials was reviewed and the special features were remarked. Due the brittleness of graphites, the damage-tolerant design procedures different from the conventional metals were adopted based on semi-probabilistic approaches. The unique additional classification, SRC, is allotted to the graphite components and the full 3-D FEM or equivalent stress analysis method is required. In specific conditions, the oxidation and viscoelasticity analysis of material are required. The fatigue damage rule has not been established yet.

  4. Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

    International Nuclear Information System (INIS)

    Riley, D; Dodson, K

    2001-01-01

    The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

  5. Computer Program of SIE ASME-NH (Revision 1.0) Code

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Gyeong Hoi; Lee, J. H

    2008-01-15

    In this report, the SIE ASME (Structural Integrity Evaluations by ASME-NH) (Revision 1.0), which has a computerized implementation of ASME Pressure Vessels and Piping Code Section III Subsection NH rules, is developed to apply to the next generation reactor design subjecting to the elevated temperature operations over 500 .deg. C and over 30 years design lifetime, and the user's manual for this program is described in detail.

  6. Computer Program of SIE ASME-NH (Revision 1.0) Code

    International Nuclear Information System (INIS)

    Koo, Gyeong Hoi; Lee, J. H.

    2008-01-01

    In this report, the SIE ASME (Structural Integrity Evaluations by ASME-NH) (Revision 1.0), which has a computerized implementation of ASME Pressure Vessels and Piping Code Section III Subsection NH rules, is developed to apply to the next generation reactor design subjecting to the elevated temperature operations over 500 .deg. C and over 30 years design lifetime, and the user's manual for this program is described in detail

  7. ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas.

    Science.gov (United States)

    Israël-Assayag, Evelyne; Beaulieu, Marie-Josée; Cormier, Yvon

    2015-01-01

    Inhaled β2-adrenoreceptor agonists are widely used in asthma and chronic obstructive pulmonary disease (COPD) for bronchoconstriction relief. β2-Adrenoreceptor agonists relax airway smooth muscle cells via cyclic adenosine monophosphate (cAMP) mediated pathways. However, prolonged stimulation induces functional desensitization of the β2-adrenoreceptors (β2-AR), potentially leading to reduced clinical efficacy with chronic or prolonged administration. ASM-024, a small synthetic molecule in clinical stage development, has shown activity at the level of nicotinic receptors and possibly at the muscarinic level and presents anti-inflammatory and bronchodilator properties. Aerosolized ASM-024 reduces airway resistance in mice and promotes in-vitro relaxation of tracheal and bronchial preparations from animal and human tissues. ASM-024 increased in vitro relaxation response to maximally effective concentration of short-acting beta-2 agonists in dog and human bronchi. Although the precise mechanisms by which ASM-024 promotes airway smooth muscle (ASM) relaxation remain unclear, we hypothesized that ASM-024 will attenuate and/or abrogate agonist-induced contraction and remain effective despite β2-AR tachyphylaxis. β2-AR tachyphylaxis was induced with salbutamol, salmeterol and formoterol on guinea pig tracheas. The addition of ASM-024 relaxed concentration-dependently intact or β2-AR desensitized tracheal rings precontracted with methacholine. ASM-024 did not induce any elevation of intracellular cAMP in isolated smooth muscle cells; moreover, blockade of the cAMP pathway with an adenylate cyclase inhibitor had no significant effect on ASM-024-induced guinea pig trachea relaxation. Collectively, these findings show that ASM-024 elicits relaxation of β2-AR desensitized tracheal preparations and suggest that ASM-024 mediates smooth muscle relaxation through a different target and signaling pathway than β2-adrenergic receptor agonists. These findings suggest ASM-024

  8. Simulation analysis of ASM/Takács models in the BSM1 configuration.

    Science.gov (United States)

    Sorour, M T; Bahgat, L M F

    2006-10-01

    The present paper summarizes the outlines of a simulation analysis study conducted on the BSM1 (formerly the COST benchmark) configuration using activated sludge models (ASM1, ASM2d and ASM3) coupled to Takács settler model. The prime objective was to develop reliable simulation software programs to implement these complex models according to the working conditions of a realistic plant. The analysis focused on comparing the steady state predictions of models ASM1/ ASM3 when imposed to pulse/ step type disturbances on wastewater characteristics and control variables, then on assessing the capability of the simulated configuration for bio-P removal using model ASM2d. Section 1 of the paper briefly presents problem definition/ solution approach while section 2 demonstrates some examples showing the main indications of the simulation analysis. ASM1/ ASM3 predictions indicate the presence of some significant differences between both models that could be related to their underlying concepts. ASM2d simulations show that adverse effects on the permissible limit of effluent's ammonia concentration should be expected when the plant is operated to achieve dual nutrient removal.

  9. Significant issues and changes for ANSI/ASME OM-1 1981, part 1, ASME OMc code-1994, and ASME OM Code-1995, Appendix I, inservice testing of pressure relief devices in light water reactor power plants

    Energy Technology Data Exchange (ETDEWEB)

    Seniuk, P.J.

    1996-12-01

    This paper identifies significant changes to the ANSI/ASME OM-1 1981, Part 1, and ASME Omc Code-1994 and ASME OM Code-1995, Appendix I, {open_quotes}Inservice Testing of Pressure Relief Devices in Light-Water Reactor Power Plants{close_quotes}. The paper describes changes to different Code editions and presents insights into the direction of the code committee and selected topics to be considered by the ASME O&M Working Group on pressure relief devices. These topics include scope issues, thermal relief valve issues, as-found and as-left set-pressure determinations, exclusions from testing, and cold setpoint bench testing. The purpose of this paper is to describe some significant issues being addressed by the O&M Working Group on Pressure Relief Devices (OM-1). The writer is currently the chair of OM-1 and the statements expressed herein represents his personal opinion.

  10. TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice.

    Science.gov (United States)

    Li, Xiang; Han, Wei-Qing; Boini, Krishna M; Xia, Min; Zhang, Yang; Li, Pin-Lan

    2013-01-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor, death receptor 4 (DR4), have been implicated in the development of endothelial dysfunction and atherosclerosis. However, the signaling mechanism mediating DR4 activation leading to endothelial injury remains unclear. We recently demonstrated that ceramide production via hydrolysis of membrane sphingomyelin by acid sphingomyelinase (ASM) results in membrane raft (MR) clustering and the formation of important redox signaling platforms, which play a crucial role in amplifying redox signaling in endothelial cells leading to endothelial dysfunction. The present study aims to investigate whether TRAIL triggers MR clustering via lysosome fusion and ASM activation, thereby conducting transmembrane redox signaling and changing endothelial function. Using confocal microscopy, we found that TRAIL induced MR clustering and co-localized with DR4 in coronary arterial endothelial cells (CAECs) isolated from wild-type (Smpd1 (+/+)) mice. Furthermore, TRAIL triggered ASM translocation, ceramide production, and NADPH oxidase aggregation in MR clusters in Smpd1 ( +/+ ) CAECs, whereas these observations were not found in Smpd1 (-/-) CAECs. Moreover, ASM deficiency reduced TRAIL-induced O(2) (-[Symbol: see text]) production in CAECs and abolished TRAIL-induced impairment on endothelium-dependent vasodilation in small resistance arteries. By measuring fluorescence resonance energy transfer, we found that Lamp-1 (lysosome membrane marker protein) and ganglioside G(M1) (MR marker) were trafficking together in Smpd1 (+/+) CAECs, which was absent in Smpd1 (-/-) CAECs. Consistently, fluorescence imaging of living cells with specific lysosome probes demonstrated that TRAIL-induced lysosome fusion with membrane was also absent in Smpd1 (-/-) CAECs. Taken together, these results suggest that ASM is essential for TRAIL-induced lysosomal trafficking, membrane fusion and formation of MR redox signaling platforms

  11. ASM Based Synthesis of Handwritten Arabic Text Pages

    Directory of Open Access Journals (Sweden)

    Laslo Dinges

    2015-01-01

    Full Text Available Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available.

  12. ASM Based Synthesis of Handwritten Arabic Text Pages.

    Science.gov (United States)

    Dinges, Laslo; Al-Hamadi, Ayoub; Elzobi, Moftah; El-Etriby, Sherif; Ghoneim, Ahmed

    2015-01-01

    Document analysis tasks, as text recognition, word spotting, or segmentation, are highly dependent on comprehensive and suitable databases for training and validation. However their generation is expensive in sense of labor and time. As a matter of fact, there is a lack of such databases, which complicates research and development. This is especially true for the case of Arabic handwriting recognition, that involves different preprocessing, segmentation, and recognition methods, which have individual demands on samples and ground truth. To bypass this problem, we present an efficient system that automatically turns Arabic Unicode text into synthetic images of handwritten documents and detailed ground truth. Active Shape Models (ASMs) based on 28046 online samples were used for character synthesis and statistical properties were extracted from the IESK-arDB database to simulate baselines and word slant or skew. In the synthesis step ASM based representations are composed to words and text pages, smoothed by B-Spline interpolation and rendered considering writing speed and pen characteristics. Finally, we use the synthetic data to validate a segmentation method. An experimental comparison with the IESK-arDB database encourages to train and test document analysis related methods on synthetic samples, whenever no sufficient natural ground truthed data is available.

  13. Radiation-induced temperature shift of thhe ASME KIc curve

    International Nuclear Information System (INIS)

    Nanstad, R.K.; Haggag, F.M.; Iskander, S.K.

    1989-01-01

    The objective of this study was to determine the effects of neutron irradiation on the temperature shift and shape of the K Ic curve described in Sect. XI of the ASME Boiler and pressure Vessel Code. Two submerged-arc welds with copper contents of 0.23 and 0.31 wt % were commercially fabricated in 215-mm-thick plate. Charpy impact, tensile, dropweight, and compact specimens up to 203.2 mm thick were fabricated and tested to provide a large data for unirradiated material. Similar specimens with compacts up to 101.6 mm thick, irradiated at about 288 degree C to a mean fluence of about 1.6 times 10 19 neutrons/cm 2 in the Oak Ridge Research Reactor, were tested to provide a similarly large data base with which to evaluate the temperature shift and shape of the ASME K Ic curves. Testing was performed by both Oak Ridge National Laboratory and Materials Engineering Associates. Both linear-elastic and elastic-plastic fracture mechanics techniques were used to analyze test results. 3 refs., 4 figs., 1 tab

  14. Limitations of ASM1 and ASM3: a comparison based on batch oxygen uptake rate profiles from different full-scale wastewater treatment plants.

    Science.gov (United States)

    Guisasola, A; Sin, G; Baeza, J A; Carrera, J; Vanrolleghem, P A

    2005-01-01

    The two most popular models for the description of the biological COD removal are ASM1 and ASM3. However, some numerical inconsistencies arise when using these models to interpret the data obtained in short-term respirometric batch experiments. In this study, both models are fitted to four different respirometric batch profiles obtained with biomass from different WWTP. The parameter estimation results and the practical (local) identifiability are analysed, and the limitations of both models are discussed. The growth yield obtained by fitting ASM1 to the short-term respirometric batch profiles is higher than the default one, as well as the storage yield obtained by fitting ASM3 is lower than the default one. Based on these values, possible improvements to the modelling of the biological COD removal, such as the inclusion of simultaneous growth and storage on external substrate, are proposed.

  15. Intramolecular Energy Transfer, Charge Transfer & Hydrogen Bond

    Indian Academy of Sciences (India)

    Ultrafast Dynamics of Chemical Reactions in Condensed Phase: Intramolecular Energy Transfer, Charge Transfer & Hydrogen Bond. Dipak K. Palit Radaition & Photochemistry Division Bhabha Atomic Research Centre Mumbai 400 085, India.

  16. Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma.

    Science.gov (United States)

    Teoh, Chun Ming; Tam, John Kit Chung; Tran, Thai

    2012-01-01

    Airway hyperresponsiveness (AHR) is one of the cardinal features of asthma. Contraction of airway smooth muscle (ASM) cells that line the airway wall is thought to influence aspects of AHR, resulting in excessive narrowing or occlusion of the airway. ASM contraction is primarily controlled by agonists that bind G protein-coupled receptor (GPCR), which are expressed on ASM. Integrins also play a role in regulating ASM contraction signaling. As therapies for asthma are based on symptom relief, better understanding of the crosstalk between GPCRs and integrins holds good promise for the design of more effective therapies that target the underlying cellular and molecular mechanism that governs AHR. In this paper, we will review current knowledge about integrins and GPCRs in their regulation of ASM contraction signaling and discuss the emerging concept of crosstalk between the two and the implication of this crosstalk on the development of agents that target AHR.

  17. ASM1-based activated sludge model with biopolymer kinetics for integrated simulation of membrane bioreactors for wastewater treatment

    OpenAIRE

    Janus, Tomasz; Ulanicki, Bogumil

    2015-01-01

    This paper presents an activated sludge model suitable for modelling membrane bioreactors (MBRs) for wastewater treatment. The model, later referred to as combined EPS and SMP production ASM1-based model (CES-ASM1), extends Activated Sludge Model No. 1 (ASM1) with biokinetics of two types of bacterial biopolymers: soluble microbial products (SMP) and extracellular polymeric substances (EPS). The biopolymer kinetics in CES-ASM1 are, in their majority, borrowed from Laspidou and Rittmann[1] ...

  18. Nuclear component design ontology building based on ASME codes

    International Nuclear Information System (INIS)

    Bao Shiyi; Zhou Yu; He Shuyan

    2005-01-01

    The adoption of ontology analysis in the study of concept knowledge acquisition and representation for the nuclear component design process based on computer-supported cooperative work (CSCW) makes it possible to share and reuse numerous concept knowledge of multi-disciplinary domains. A practical ontology building method is accordingly proposed based on Protege knowledge model in combination with both top-down and bottom-up approaches together with Formal Concept Analysis (FCA). FCA exhibits its advantages in the way it helps establish and improve taxonomic hierarchy of concepts and resolve concept conflict occurred in modeling multi-disciplinary domains. With Protege-3.0 as the ontology building tool, a nuclear component design ontology based ASME codes is developed by utilizing the ontology building method. The ontology serves as the basis to realize concept knowledge sharing and reusing of nuclear component design. (authors)

  19. 76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Science.gov (United States)

    2011-03-01

    ... Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code AGENCY... the electronic availability of the American Society of Mechanical Engineers' (ASME) Boiler and... the ANPRM published on December 23, 2010 (ANPRM; 75 FR 80765). The ASME Boiler and Pressure Vessel...

  20. Regulation of dynein-mediated autophagosomes trafficking by ASM in CASMCs.

    Science.gov (United States)

    Xu, Ming; Zhang, Qiufang; Li, Pin-Lan; Nguyen, Thaison; Li, Xiang; Zhang, Yang

    2016-01-01

    Acid sphingomyelinase (ASM; gene symbol Smpd1) has been shown to play a crucial role in autophagy maturation by controlling lysosomal fusion with autophagosomes in coronary arterial smooth muscle cells (CASMCs). However, the underlying molecular mechanism by which ASM controls autophagolysosomal fusion remains unknown. In primary cultured CASMCs, lysosomal Ca2+ induced by 7-ketocholesterol (7-Ket, an atherogenic stimulus and autophagy inducer) was markedly attenuated by ASM deficiency or TRPML1 gene silencing suggesting that ASM signaling is required for TRPML1 channel activity and subsequent lysosomal Ca(2+) release. In these CASMCs, ASM deficiency or TRPML1 gene silencing markedly inhibited 7-Ket-induced dynein activation. In addition, 7-Ket-induced autophagosome trafficking, an event associated with lysosomal Ca(2+) release and dynein activity, was significantly inhibited in ASM-deficient (Smpd1(-/-)) CASMCs compared to that in Smpd1(+/+) CASMCs. Finally, overexpression of TRPML1 proteins restored 7-Ket-induced lysosomal Ca(2+) release and autophagosome trafficking in Smpd1-/- CASMCs. Collectively, these results suggest that ASM plays a critical role in regulating lysosomal TRPML1-Ca(2+) signaling and subsequent dynein-mediated autophagosome trafficking, which leads its role in controlling autophagy maturation in CASMCs under atherogenic stimulation.

  1. Reactor Engineering Division annual report

    International Nuclear Information System (INIS)

    Hirota, Jitsuya; Asaoka, Takumi; Suzuki, Tomoo; Mitani, Hiroshi; Akino, Fujiyoshi

    1977-09-01

    Research activities in the Division of Reactor Engineering in fiscal 1976 are described. Works of the division concern mainly the development of multi-purpose Very High Temperature Gas Cooled Reactor, fusion reactor engineering, and the development of Liquid Metal Fast Breeder Reactor in Power Reactor and Nuclear Fuel Development Corporation. Contents of the report are nuclear data and group constants, theoretical method and code development, integral experiment and analysis, shielding, heat transfer and fluid dynamics, reactor and nuclear instrumentation, dynamics analysis and control method development, fusion reactor technology, and activities of the Committee on Reactor Physics. (auth.)

  2. Reactor Engineering Division annual report

    International Nuclear Information System (INIS)

    1975-11-01

    Research activities in fiscal 1974 in Reactor Engineering Division of eight laboratories and computing center are described. Works in the division are closely related with the development of a multi-purpose High-temperature Gas Cooled Reactor, the development of a Liquid Metal Fast Breeder Reactor in Power Reactor and Nuclear Fuel Development Corporation, and engineering of thermonuclear fusion reactors. They cover nuclear data and group constants, theoretical method and code development, integral experiment and analysis, shielding, heat transfer and fluid dynamics, reactor and nuclear instrumentation, dynamics analysis and control method development, fusion reactor technology and aspects of the computing center. (auth.)

  3. Reactor Engineering Division annual report

    International Nuclear Information System (INIS)

    1976-09-01

    Research activities conducted in Reactor Engineering Division in fiscal 1975 are summarized in this report. Works in the division are closely related to the development of multi-purpose High-temperature Gas Cooled Reactor, the development of Liquid Metal Fast Breeder Reactor by Power Reactor and Nuclear Fuel Development Corporation, and engineering research of thermonuclear fusion reactor. Many achievements are described concerning nuclear data and group constants, theoretical method and code development, integral experiment and analysis, shielding, heat transfer and fluid dynamics, reactor and nuclear instrumentation, dynamics analysis and control method development, fusion reactor technology and activities of the Committee on Reactor Physics. (auth.)

  4. Passport of global nuclear business. ASME code certificate acquirement and inspection practices

    International Nuclear Information System (INIS)

    Kawabata, Hiroyuki; Terajima, Makoto; Anami, Kazuhiro

    2010-01-01

    There are possibilities of Japanese nuclear industries to participate in global business such as new and additional construction of nuclear power plants in US and also Asian and other developing countries in the world. It is requisite to acquire ASME code certificate for global business participation, just as passport. This article consists of five papers on present status of ASME code certificate acquirement and inspection practices of nuclear components vendors in the area of Japanese nuclear business. Activities of JSME Committee on Power Generation Facility Codes to make JSME codes corresponded to ASME nuclear codes and standards for their international deployment are also described. (T. Tanaka)

  5. [Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

    Science.gov (United States)

    Sweeney, David; Hollins, Fay; Gomez, Edith; Saunders, Ruth; Challiss, R A John; Brightling, Christopher E

    2014-07-01

    The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation. © 2014 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology.

  6. The ASM Curriculum Guidelines for Undergraduate Microbiology: A Case Study of the Advocacy Role of Societies in Reform Efforts.

    Science.gov (United States)

    Horak, Rachel E A; Merkel, Susan; Chang, Amy

    2015-05-01

    A number of national reports, including Vision and Change in Undergraduate Biology Education: A Call to Action, have called for drastic changes in how undergraduate biology is taught. To that end, the American Society for Microbiology (ASM) has developed new Curriculum Guidelines for undergraduate microbiology that outline a comprehensive curriculum for any undergraduate introductory microbiology course or program of study. Designed to foster enduring understanding of core microbiology concepts, the Guidelines work synergistically with backwards course design to focus teaching on student-centered goals and priorities. In order to qualitatively assess how the ASM Curriculum Guidelines are used by educators and learn more about the needs of microbiology educators, the ASM Education Board distributed two surveys to the ASM education community. In this report, we discuss the results of these surveys (353 responses). We found that the ASM Curriculum Guidelines are being implemented in many different types of courses at all undergraduate levels. Educators indicated that the ASM Curriculum Guidelines were very helpful when planning courses and assessments. We discuss some specific ways in which the ASM Curriculum Guidelines have been used in undergraduate classrooms. The survey identified some barriers that microbiology educators faced when trying to adopt the ASM Curriculum Guidelines, including lack of time, lack of financial resources, and lack of supporting resources. Given the self-reported challenges to implementing the ASM Curriculum Guidelines in undergraduate classrooms, we identify here some activities related to the ASM Curriculum Guidelines that the ASM Education Board has initiated to assist educators in the implementation process.

  7. Design analysis report for the 244-AR vault Interim Stabilization interior transfer system

    International Nuclear Information System (INIS)

    CARLSON, A.B.

    2002-01-01

    The purpose of this calculation note is to verify that the 244-AR Vault Interior Transfer System piping installed in the vault meets ASME B31.3 code requirements. This calculation also evaluates the pipe support loads

  8. Recruiting and retaining geoscience students at a large public university: Balancing the needs of first-time freshman and upper-division transfer students

    Science.gov (United States)

    Bowman, D. D.; Clemens-Knott, D.

    2012-12-01

    The Department of Geological Sciences at California State University, Fullerton (CSUF) is one of the largest geology programs in the state. Approximately 4,000 students at CSUF take general education geology classes; this provides a large pool from which to recruit undergraduate students for either the Geology B.S. or Earth Sciences B.A. offered by the department. The department has seen a dramatic increase in majors over the last decade, from a low of 28 majors in 2002 to more than 110 in 2012. This increase does not appear to be driven by growth in the oil industry; in a recent survey of CSUF geoscience (BS or BA) students, 15% of respondents indicated an interest in a career in petroleum. The department has engaged in aggressive recruitment and outreach efforts over the last decade, with activities ranging from earthquake preparedness rallies in conjunction with the annual California ShakeOut, to an emerging high school and community college intern program at the department's paleontology curation facility. Despite these efforts, the majority of CSUF geoscience students declared the geology major after taking an introductory physical geology course either at CSUF or a local community college. Over the last ten years, approximately 50% of the geoscience majors at CSUF transferred from a community college. Among the geoscience students who began their career at CSUF, only one third had declared a geoscience major in their freshman year. Over two thirds of geoscience majors at CSUF declared their major after completing more than 60 units. The strong tendency for students to declare a geoscience major late in their career poses significant challenges to students' ability to graduate in a timely manner. To mitigate this problem, the department has an aggressive advising program, wherein students attend mandatory advising with a faculty member every semester. The department is also working closely with community college partners to improve the preparation of transfer

  9. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    Science.gov (United States)

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  10. Estimates of margins in ASME Code strength values for stainless steel nuclear piping

    International Nuclear Information System (INIS)

    Ware, A.G.

    1995-01-01

    The margins in the ASME Code stainless steel allowable stress values that can be attributed to the variations in material strength are evaluated for nuclear piping steels. Best-fit curves were calculated for the material test data that were used to determine allowable stress values for stainless steels in the ASME Code, supplemented by more recent data, to estimate the mean stresses. The mean yield stresses from the test data are about 15 to 20% greater than the ASME Code yield stress values (the stainless steel S m values are based on the yield stress). The ASME Code yield stress values are estimated to approximately coincide with the 97% confidence limit from the test data. The mean and 97% confidence limit values can be used in probabilistic risk assessments of nuclear piping

  11. 115-year-old society knows how to reach young scientists: ASM Young Ambassador Program.

    Science.gov (United States)

    Karczewska-Golec, Joanna

    2015-12-25

    With around 40,000 members in more than 150 countries, American Society for Microbiology (ASM) faces the challenge of meeting very diverse needs of its increasingly international members base. The newly launched ASM Young Ambassador Program seeks to aid the Society in this effort. Equipped with ASM conceptual support and financing, Young Ambassadors (YAs) design and pursue country-tailored approaches to strengthen the Society's ties with local microbiological communities. In a trans-national setting, the active presence of YAs at important scientific events, such as 16th European Congress on Biotechnology, forges new interactions between ASM and sister societies. The paper presents an overview of the Young Ambassadors-driven initiatives at both global and country levels, and explores the topic of how early-career scientists can contribute to science diplomacy and international relations. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. NRC needs and their implementation-ASME Section IX code

    International Nuclear Information System (INIS)

    Liaw, B.D.

    1985-01-01

    The guiding principle from the onset of government regulation for the peaceful use of nuclear energy has been to prescribe only the minimum requirements that are needed for safety. In the pioneer regulators' collective mind, the technical details could be left to the regulated industry through its agents like NSSS vendors and A/E's and their surrogate organizations like ASME, ANS, AIF, etc. However, it has evolved through the years, due either to the bureaucratic momentum or the vacuum in industry leadership, into a situation where one sees an ever increasing number of detailed ''requirements'' prescribed by the regulators. Within the scope of activities covered by Section XI, there is no exception: e.g., NUREG-067, -0531 -1061; NUREG-0313 Rev. 0, Rev. 1, and now Rev. 2; IE Bulletins 82-03, 83-02; and Generic Letters 84-11, and 84-07, etc. for one issue of pipe crack alone; and there are more to come. There appears a consensus among all concerned parties including regulators that this is not a desirable situation and that something must be done to reverse this trend. The purpose of this discussion is, therefore, to explore the areas where the Section XI Code can be restructured to meet this need, and to seek ideas from the representatives of the regulated industry on the methods of implementation that are effective, efficient, and acceptable to all concerned parties

  13. ASME Section XI trends in developing nuclear codes and standards

    International Nuclear Information System (INIS)

    Hedden, O.F.

    1995-01-01

    When the author began working on nuclear power many years ago, he knew that perfection was the only acceptable technical standard. Unfortunately, this became an obsession with perfection that has had unfavorable consequences in some of the non-technical areas of work in ASME nuclear power Codes and Standards. However, the economic problems of the nuclear power industry now demand a more pragmatic approach if the industry is to continue. Not only does each item considered for action need to be evaluated to criteria that may in some cases be less than perfection, but one needs to consider whether it contributes tangibly to either safety or to reduction in technical or administrative burden. These should be the governing, criteria. The introduction of risk-based inspection methodologies will certainly be an important element in doing this successfully. One needs to consider these criteria collectively, as one discusses each item at the committee level, and individually, as one votes on each item. In the past, the author has been concerned that the industry was not acting quickly enough in taking advantage of opportunities offered by the Code to increase safety or to reduce cost. While he still has some concern, he thinks communication channels have been greatly improved. Now he is becoming more concerned with both the collective and individual actions that delay beneficial changes. The second part of the author's talk has to do with the relevance of the code committees in the nuclear power industry regulatory process

  14. Measurement of large ground motions with the ASM gage

    International Nuclear Information System (INIS)

    Wright, B.L.; Alrick, K.R.; Fritz, J.N.

    1994-01-01

    Conversion of the energy from undergound explosions to distant seismic signals involves hydrodynamic flows sampling a wide range of pressures. For lower pressures a larger portion of the initial wave motion must be measured to obtain definitive results. The intermediate pressure range, where the initial wave is strong enough to destroy most instrumentation but does not contain definitive information in its initial amplitude, presents special difficulties. We present design considerations for an experiment implementing the ASM gage principle (induction of eddy currents in a moving conducting plate) that can sample wave motion for many milliseconds. In essence we hang a large metal plate (large in area) on a wall and watch the free-surface release. This is not an in-itu measurement of the wave profile because the incoming wave is modififed by the release propagating backward from the wall. However, this a relatively clean modification of the incoming wave and is a situation commonly handled in many shock-wave experiments. copyright American Institute of Physics

  15. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis.

    Science.gov (United States)

    Luger, T; Van Leent, E J; Graeber, M; Hedgecock, S; Thurston, M; Kandra, A; Berth-Jones, J; Bjerke, J; Christophers, E; Knop, J; Knulst, A C; Morren, M; Morris, A; Reitamo, S; Roed-Petersen, J; Schoepf, E; Thestrup-Pedersen, K; Van Der Valk, P G; Bos, J D

    2001-04-01

    SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. This study was designed to determine the safety and efficacy of SDZ ASM 981 cream at concentrations of 0.05%, 0.2%, 0.6% and 1.0% in the treatment of patients with atopic dermatitis and to select the concentration to be used in phase III studies. This was a double-blind, randomized, parallel-group, multicentre dose-finding study. A total of 260 patients were randomly assigned to treatment with SDZ ASM 981 cream at concentrations of 0.05%, 0.2%, 0.6%, or 1.0%, matching vehicle cream, or the internal control 0.1% betamethasone-17-valerate cream (BMV). Treatment was given twice daily for up to 3 weeks. A clear dose-response relationship for SDZ ASM 981 was evident, with 0.2%, 0.6% and 1.0% SDZ ASM 981 creams all being significantly more effective than vehicle (P = 0.041, 0.001 and 0.008, respectively) in terms of baseline to end-point changes in the Eczema Area Severity Index (EASI) and pruritus score. The 1.0% cream was the most effective SDZ ASM 981 concentration. BMV was more effective than the SDZ ASM 981 creams tested in this study. It appears that the efficacy plateau was not reached with the SDZ ASM 981 creams within 3 weeks treatment. SDZ ASM 981 was well tolerated. Burning or a feeling of warmth were the only adverse events reported more frequently in the 0.6% and 1.0% SDZ ASM 981 treatment groups than in the vehicle treatment group (42.9%, 48.9% and 34.9%, respectively). Few systemic adverse events were reported during the study (headache was the most frequent systemic event reported by 15 of 252 patients) and none was considered to be related to treatment. The local tolerability profile of the 1.0% cream was similar to that of the lower concentrations. 1.0% SDZ ASM 981 cream, which was shown to be safe, well tolerated and

  16. ASME nuclear codes and standards: Scope of coverage and current initiatives

    International Nuclear Information System (INIS)

    Eisenberg, G. M.

    1995-01-01

    The objective of this paper is to address the broad scope of coverage of nuclear codes, standards and guides produced and administered by the American Society of Mechanical Engineers (ASME). Background information is provided regarding the evolution of the present activities. Details are provided on current initiatives intended to permit ASME to meet the needs of a changing nuclear industry on a worldwide scale. During the early years of commercial nuclear power, ASME produced a code for the construction of nuclear vessels used in the reactor coolant pressure boundary, containment and auxiliary systems. In response to industry growth, ASME Code coverage soon broadened to include rules for construction of other nuclear components, and inservice inspection of nuclear reactor coolant systems. In the years following this, the scope of ASME nuclear codes, standards and guides has been broadened significantly to include air cleaning activities for nuclear power reactors, operation and maintenance of nuclear power plants, quality assurance programs, cranes for nuclear facilities, qualification of mechanical equipment, and concrete reactor vessels and containments. ASME focuses on globalization of its codes, standards and guides by encouraging and promoting their use in the international community and by actively seeking participation of international members on its technical and supervisory committees and in accreditation activities. Details are provided on current international representation. Initiatives are underway to separate the technical requirements from administrative and enforcement requirements, to convert to hard metric units, to provide for non-U. S. materials, and to provide for translations into non-English languages. ASME activity as an accredited ISO 9000 registrar for suppliers of mechanical equipment is described. Rules are being developed for construction of containment systems for nuclear spent fuel and high-level waste transport packagings. Intensive

  17. cASM: Obtaining the Ability to Capture Requirements Information Across the Installation Contracting Support Community

    Science.gov (United States)

    2016-04-22

    social impact to the local populace, but this effect must be closely tied to the strategic effects desired.19 An ill planned acquisition could lead to...21 EVALUATION – CONTINGENCY ACQUISTION SUPPORT MODEL (cASM...iv LIST OF FIGURES Figure 1: Top Twenty Contingency Acquisition Expenditures by PSC…………….……….18 Figure 2: Evaluation of cASM

  18. Acid Sphingomyelinase (ASM is a Negative Regulator of Regulatory T Cell (Treg Development

    Directory of Open Access Journals (Sweden)

    Yuetao Zhou

    2016-08-01

    Full Text Available Background/Aims: Regulatory T cell (Treg is required for the maintenance of tolerance to various tissue antigens and to protect the host from autoimmune disorders. However, Treg may, indirectly, support cancer progression and bacterial infections. Therefore, a balance of Treg function is pivotal for adequate immune responses. Acid sphingomyelinase (ASM is a rate limiting enzyme involved in the production of ceramide by breaking down sphingomyelin. Previous studies in T-cells have suggested that ASM is involved in CD28 signalling, T lymphocyte granule secretion, degranulation, and vesicle shedding similar to the formation of phosphatidylserine-exposing microparticles from glial cells. However, whether ASM affects the development of Treg has not yet been described. Methods: Splenocytes, isolated Naive T lymphocytes and cultured T cells were characterized for various immune T cell markers by flow cytometery. Cell proliferation was measured by Carboxyfluorescein succinimidyl ester (CFSE dye, cell cycle analysis by Propidium Iodide (PI, mRNA transcripts by q-RT PCR and protein expression by Western Blotting respectively. Results: ASM deficient mice have higher number of Treg compared with littermate control mice. In vitro induction of ASM deficient T cells in the presence of TGF-β and IL-2 lead to a significantly higher number of Foxp3+ induced Treg (iTreg compared with control T-cells. Further, ASM deficient iTreg has less AKT (serine 473 phosphorylation and Rictor levels compared with control iTreg. Ceramide C6 led to significant reduction of iTreg in both ASM deficient and WT mice. The reduction in iTreg leads to induction of IL-1β, IL-6 and IL-17 but not IFN-γ mRNA levels. Conclusion: ASM is a negative regulator of natural and iTreg.

  19. Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development.

    Science.gov (United States)

    Zhou, Yuetao; Salker, Madhuri S; Walker, Britta; Münzer, Patrick; Borst, Oliver; Gawaz, Meinrad; Gulbins, Erich; Singh, Yogesh; Lang, Florian

    2016-01-01

    Regulatory T cell (Treg) is required for the maintenance of tolerance to various tissue antigens and to protect the host from autoimmune disorders. However, Treg may, indirectly, support cancer progression and bacterial infections. Therefore, a balance of Treg function is pivotal for adequate immune responses. Acid sphingomyelinase (ASM) is a rate limiting enzyme involved in the production of ceramide by breaking down sphingomyelin. Previous studies in T-cells have suggested that ASM is involved in CD28 signalling, T lymphocyte granule secretion, degranulation, and vesicle shedding similar to the formation of phosphatidylserine-exposing microparticles from glial cells. However, whether ASM affects the development of Treg has not yet been described. Splenocytes, isolated Naive T lymphocytes and cultured T cells were characterized for various immune T cell markers by flow cytometery. Cell proliferation was measured by Carboxyfluorescein succinimidyl ester (CFSE) dye, cell cycle analysis by Propidium Iodide (PI), mRNA transcripts by q-RT PCR and protein expression by Western Blotting respectively. ASM deficient mice have higher number of Treg compared with littermate control mice. In vitro induction of ASM deficient T cells in the presence of TGF-β and IL-2 lead to a significantly higher number of Foxp3+ induced Treg (iTreg) compared with control T-cells. Further, ASM deficient iTreg has less AKT (serine 473) phosphorylation and Rictor levels compared with control iTreg. Ceramide C6 led to significant reduction of iTreg in both ASM deficient and WT mice. The reduction in iTreg leads to induction of IL-1β, IL-6 and IL-17 but not IFN-γ mRNA levels. ASM is a negative regulator of natural and iTreg. © 2016 The Author(s) Published by S. Karger AG, Basel.

  20. Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand.

    Science.gov (United States)

    Watson, Brittany M; Oliveria, John Paul; Nusca, Graeme M; Smith, Steven G; Beaudin, Sue; Dua, Benny; Watson, Rick M; Assayag, Evelynne Israël; Cormier, Yvon F; Sehmi, Roma; Gauvreau, Gail M

    2014-01-01

    Nicotinic acetylcholine receptors (nAChRs) were identified on eosinophils and shown to regulate inflammatory responses, but nAChR expression on basophils has not been explored yet. We investigated surface receptor expression of nAChR α4, α7 and α1/α3/α5 subunits on basophils. Furthermore, we examined the effects of ASM-024, a synthetic nicotinic ligand, on in vitro anti-IgE and in vivo allergen-induced basophil activation. Basophils were enriched from the peripheral blood of allergic donors and the expression of nAChR subunits and muscarinic receptors was determined. Purified basophils were stimulated with anti-IgE in the presence of ASM-024 with or without muscarinic or nicotinic antagonists for the measurement of CD203c expression and histamine release. The effect of 9 days of treatment with 50 and 200 mg ASM-024 on basophil CD203c expression was examined in the blood of mild allergic asthmatics before and after allergen inhalation challenge. nAChR α4, α7 and α1/α3/α5 receptor subunit expression was detected on basophils. Stimulation of basophils with anti-IgE increased CD203c expression and histamine release, which was inhibited by ASM-024 (10(-5) to 10(-)(3) M, p ASM-024 was reversed in the presence of muscarinic and nicotinic antagonists. In subjects with mild asthma, ASM-024 inhalation significantly inhibited basophil CD203c expression measured 24 h after allergen challenge (p = 0.03). This study shows that ASM-024 inhibits IgE- and allergen-induced basophil activation through both nicotinic and muscarinic receptors, and suggests that ASM-024 may be an efficacious agent for modulating allergic asthma responses. © 2015 S. Karger AG, Basel.

  1. Revision of the ASME nuclear quality assurance standard and its historical background

    International Nuclear Information System (INIS)

    Suzuki, Tetsuya

    2009-01-01

    ASME NQA-1-2008 'Quality Assurance Requirements for Nuclear Facility Applications' will be endorsed by US NRC by the end of 2009. This standard will apply to design, construction and operation of nuclear power plants newly erected in USA. It is important to Japanese vendors developing nuclear business in USA. Historical background, significance of revision and main revised points of the ASME nuclear quality assurance standard are described in the present paper. (T. Tanaka)

  2. Application procedures and analysis examples of the SIE ASME-NH program

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seok Hoon; Koo, G. H.; Kim, J. B. [KAERI, Daejeon (Korea, Republic of)

    2010-12-15

    In this report, the design rule of the ASME-NH Code was briefly summarized and the application procedures of SIE ASME-NH program were analysed, the analysis examples were described. The SIE ASME-NH program was developed according to the ASME Code Section III Subsection NH rules to perform the primary stress limits, the accumulated inelastic strain limits and the creep fatigue damage evaluations in the structural design of nuclear power plants operating with high temperatures over creep temperature at normal operating conditions. In the analysis examples, the benchmark problem for the high temperature reactor vessel which was discussed in the SIE ASME-NH user's seminar was described. Also, the preliminary structural analysis of an Advanced Burner Test Reactor internal structure was described. Considering the load combinations of the various cycle types submitted from significant operating conditions, the integrity of a reactor internal structure was reviewed according to the stress and strain limits of the ASME-NH rules and the analysis and evaluation results were summarized

  3. Application procedures and analysis examples of the SIE ASME-NH program

    International Nuclear Information System (INIS)

    Kim, Seok Hoon; Koo, G. H.; Kim, J. B.

    2010-12-01

    In this report, the design rule of the ASME-NH Code was briefly summarized and the application procedures of SIE ASME-NH program were analysed, the analysis examples were described. The SIE ASME-NH program was developed according to the ASME Code Section III Subsection NH rules to perform the primary stress limits, the accumulated inelastic strain limits and the creep fatigue damage evaluations in the structural design of nuclear power plants operating with high temperatures over creep temperature at normal operating conditions. In the analysis examples, the benchmark problem for the high temperature reactor vessel which was discussed in the SIE ASME-NH user's seminar was described. Also, the preliminary structural analysis of an Advanced Burner Test Reactor internal structure was described. Considering the load combinations of the various cycle types submitted from significant operating conditions, the integrity of a reactor internal structure was reviewed according to the stress and strain limits of the ASME-NH rules and the analysis and evaluation results were summarized

  4. A Minimal Path Searching Approach for Active Shape Model (ASM)-based Segmentation of the Lung.

    Science.gov (United States)

    Guo, Shengwen; Fei, Baowei

    2009-03-27

    We are developing a minimal path searching method for active shape model (ASM)-based segmentation for detection of lung boundaries on digital radiographs. With the conventional ASM method, the position and shape parameters of the model points are iteratively refined and the target points are updated by the least Mahalanobis distance criterion. We propose an improved searching strategy that extends the searching points in a fan-shape region instead of along the normal direction. A minimal path (MP) deformable model is applied to drive the searching procedure. A statistical shape prior model is incorporated into the segmentation. In order to keep the smoothness of the shape, a smooth constraint is employed to the deformable model. To quantitatively assess the ASM-MP segmentation, we compare the automatic segmentation with manual segmentation for 72 lung digitized radiographs. The distance error between the ASM-MP and manual segmentation is 1.75 ± 0.33 pixels, while the error is 1.99 ± 0.45 pixels for the ASM. Our results demonstrate that our ASM-MP method can accurately segment the lung on digital radiographs.

  5. Equilíbrio corporal em crianças e adolescentes asmáticos e não asmáticos

    Directory of Open Access Journals (Sweden)

    Marta Cristina Rodrigues da Silva

    2013-06-01

    Full Text Available O objetivo foi analisar e comparar o equilíbrio corporal em crianças e adolescentes asmáticos e não asmáticos. Fizeram parte do grupo de estudos 24 sujeitos com idades de 7 a 14 anos divididos em dois grupos: grupo asmático e grupo controle. Para avaliação do equilíbrio corporal utilizou-se uma plataforma de força. Foram utilizadas as condições, olhos abertos e fechados com três tentativas aleatórias, com duração de 30 segundos cada uma. Os resultados apontaram diferença significativa entre os grupos, no teste de equilíbrio com olhos abertos apresentando maior amplitude de deslocamento na direção ântero-posterior (COPap (p = 0,04, e médio lateral (COPml (p = 0,02 no grupo asmático. Enquanto que no teste com olhos fechados a diferença foi significante apenas na amplitude de deslocamento ântero-posterior (COPap (p = 0,02 e Área de Elipse (p=0,03. Desse modo, a asma com suas limitações e consequências parece influenciar negativamente no equilíbrio corporal de seus portadores quando comparados com crianças sem a patologia e da mesma faixa etária.

  6. 46 CFR 56.01-5 - Adoption of ASME B31.1 for power piping, and other standards.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of ASME B31.1 for power piping, and other... ENGINEERING PIPING SYSTEMS AND APPURTENANCES General § 56.01-5 Adoption of ASME B31.1 for power piping, and... accordance with ASME B31.1 (incorporated by reference; see 46 CFR 56.01-2), as limited, modified, or replaced...

  7. Roles of the Outer Membrane Protein AsmA of Salmonella enterica in the Control of marRAB Expression and Invasion of Epithelial Cells▿

    OpenAIRE

    Prieto, Ana I.; Hernández, Sara B.; Cota, Ignacio; Pucciarelli, M. Graciela; Orlov, Yuri; Ramos-Morales, Francisco; García-del Portillo, Francisco; Casadesús, Josep

    2009-01-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S....

  8. Science of Casting and Solidification: ASM Handbook Contributions — Honoring Professor Doru Michael Stefanescu

    Science.gov (United States)

    Lupulescu, Afina; Henry, Scott; Marken, Karen; Lampman, Steven

    Many of the metal casting processes are still empirical in nature. Many others are deeply rooted in mathematics and therefore, suitable for modeling. Science of casting and solidification is a major technical asset for foundry operations and of extreme importance in understanding different length scales microstructural changes and evolution as well as developing new processes and materials. In his attempt to describe combinations of solidification theory, research results and industrial practice, Professor Doru Michael Stefanescu (ASM Fellow, 1997) has made tremendous contributions to the field. Many of his views on casting and solidification are valued as important impacts within professional environments such as TMS and ASM International. He has written many articles for the ASM Handbook series on subjects including basic metallurgy of cast iron, compacted graphite irons, solidification, thermodynamic properties of iron-base alloys, and computational modeling. He was also Volume Chair for Volume 15: Casting, of the 9th Edition Metals Handbook.

  9. Basic requirements of mechanical properties for nuclear pressure vessel materials in ASME-BPV code

    International Nuclear Information System (INIS)

    Ning Dong; Yao Weida

    2011-01-01

    The four basic aspects of strengths, ductility, toughness and fatigue strengths can be summarized for overall mechanical properties requirements of materials for nuclear pressure-retaining vessels in ASME-BPV code. These mechanical property indexes involve in the factors of melting, manufacture, delivery conditions, check or recheck for mechanical properties and chemical compositions, etc. and relate to degradation and damage accumulation during the use of materials. This paper specifically accounts for the basic requirements and theoretic basis of mechanical properties for nuclear pressure vessel materials in ASME-BPV code and states the internal mutual relationships among the four aspects of mechanical properties. This paper focuses on putting forward at several problems on mechanical properties of materials that shall be concerned about during design and manufacture for nuclear pressure vessels according to ASME-BPV code. (author)

  10. Corticosteroids reduce IL-6 in ASM cells via up-regulation of MKP-1.

    Science.gov (United States)

    Quante, Timo; Ng, Yee Ching; Ramsay, Emma E; Henness, Sheridan; Allen, Jodi C; Parmentier, Johannes; Ge, Qi; Ammit, Alaina J

    2008-08-01

    The mechanisms by which corticosteroids reduce airway inflammation are not completely understood. Traditionally, corticosteroids were thought to inhibit cytokines exclusively at the transcriptional level. Our recent evidence, obtained in airway smooth muscle (ASM), no longer supports this view. We have found that corticosteroids do not act at the transcriptional level to reduce TNF-alpha-induced IL-6 gene expression. Rather, corticosteroids inhibit TNF-alpha-induced IL-6 secretion by reducing the stability of the IL-6 mRNA transcript. TNF-alpha-induced IL-6 mRNA decays at a significantly faster rate in ASM cells pretreated with the corticosteroid dexamethasone (t(1/2) = 2.4 h), compared to vehicle (t(1/2) = 9.0 h; P ASM cells.

  11. Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition.

    Science.gov (United States)

    Allen, Jodi C; Seidel, Petra; Schlosser, Tobias; Ramsay, Emma E; Ge, Qi; Ammit, Alaina J

    2012-01-01

    Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics. We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G(1) cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB. While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone. This was independent of a repressive effect on glucocorticoid receptor translocation. Our results corroborate evidence demonstrating that corticosteroids inhibit mitogen-induced proliferation only in ASM cells from subjects without asthma and suggest that there are corticosteroid-insensitive proliferative pathways in asthmatics.

  12. Reactor Engineering Division annual report

    International Nuclear Information System (INIS)

    1975-02-01

    This report summarizes main research achievements in the 48th fiscal year which were made by Reactor Engineering Division consisted of eight laboratories and Computing Center. The major research and development projects, with which the research programmes in the Division are associated, are development of High Temperature Gas Cooled Reactor for multi-purpose use, development of Liquid Metal Fast Breeder Reactor conducted by Power Reactor and Nuclear Fuel Development Corporation, and Engineering Research Programme for Thermonuclear Fusion Reactor. Many achievements are reported in various research items such as nuclear data and group constants, theoretical method and code development, integral experiment and analysis, shielding, heat transfer and fluid dynamics, reactor and nuclear instrumentation, dynamics analysis and control method development, fusion reactor technology and activities of Computing Center. (auth.)

  13. ASME and RCC-MR comparison for the prevention of fatigue analysis

    International Nuclear Information System (INIS)

    Autrusson, B.; Acker, D.

    1989-01-01

    The purpose of this survey is to compare the simplified methods, without reference to the safety factor allowed for the mechanical properties. An application of both codes, RCC-MR and ASME, on the design of the wall mock-up of the NET project is made and also an estimation with an elastoplastic analysis. In the case of fatigue analysis according to ASME in the plastic field, the elastic stress is magnified by a K e factor derived from stress variation, S n , disregarding geometrical discontinuities. According to RCC-MR, the elastic maximum strain will magnified by two coefficients accounting for plasticity and variation of Poisson ratio

  14. A Survey of Variable Extragalactic Sources with XTE's All Sky Monitor (ASM)

    Science.gov (United States)

    Jernigan, Garrett

    1998-01-01

    The original goal of the project was the near real-time detection of AGN utilizing the SSC 3 of the ASM on XTE which does a deep integration on one 100 square degree region of the sky. While the SSC never performed sufficiently well to allow the success of this goal, the work on the project has led to the development of a new analysis method for coded aperture systems which has now been applied to ASM data for mapping regions near clusters of galaxies such as the Perseus Cluster and the Coma Cluster. Publications are in preparation that describe both the new method and the results from mapping clusters of galaxies.

  15. ASM LabCap's contributions to disease surveillance and the International Health Regulations (2005).

    Science.gov (United States)

    Specter, Steven; Schuermann, Lily; Hakiruwizera, Celestin; Sow, Mah-Séré Keita

    2010-12-03

    The revised International Health Regulations [IHR(2005)], which requires the Member States of the World Health Organization (WHO) to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005) Core Capacity #8, "Laboratory", requires that laboratory services be a part of every phase of alert and response.Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM) established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM's vast resources and its membership's expertise-40,000 microbiologists worldwide-to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap's program activities align with HR(2005) by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes.ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC) and under a sub-contract with the Program for Appropriate Technology in Health (PATH) funded by the United States Agency for International Development (USAID

  16. 46 CFR 52.01-2 - Adoption of section I of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section I of the ASME Boiler and Pressure... and Pressure Vessel Code. (a) Main power boilers and auxiliary boilers shall be designed, constructed, inspected, tested, and stamped in accordance with section I of the ASME Boiler and Pressure Vessel Code...

  17. 46 CFR 53.01-3 - Adoption of section IV of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Adoption of section IV of the ASME Boiler and Pressure... Boiler and Pressure Vessel Code. (a) Heating boilers shall be designed, constructed, inspected, tested, and stamped in accordance with section IV of the ASME Boiler and Pressure Vessel Code (incorporated by...

  18. Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency.

    Science.gov (United States)

    Acuña, Mariana; Castro-Fernández, Víctor; Latorre, Mauricio; Castro, Juan; Schuchman, Edward H; Guixé, Victoria; González, Mauricio; Zanlungo, Silvana

    2016-10-21

    Niemann-Pick disease (NPD) type A and B are recessive hereditary disorders caused by deficiency in acid sphingomyelinase (ASM). The p.Ala359Asp mutation has been described in several patients but its functional and structural effects in the protein are unknown. In order to characterize this mutation, we modeled the three-dimensional ASM structure using the recent available crystal of the mammalian ASM as a template. We found that the p.Ala359Asp mutation is localized in the hydrophobic core and far from the sphingomyelin binding site. However, energy function calculations using statistical potentials indicate that the mutation causes a decrease in ASM stability. Therefore, we investigated the functional effect of the p.Ala359Asp mutation in ASM expression, secretion, localization and activity in human fibroblasts. We found a 3.8% residual ASM activity compared to the wild-type enzyme, without changes in the other parameters evaluated. These results support the hypothesis that the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity. A similar effect was observed in other previously described NPDB mutations located outside the active site of the enzyme. This work shows the first full size ASM mutant model describe at date, providing a complete analysis of the structural and functional effects of the p.Ala359Asp mutation over the stability and activity of the enzyme. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. The 1997 NRC IST workshops and the status of questions and issues directed to the ASME O and M committee

    International Nuclear Information System (INIS)

    DiBiasio, A.M.

    1998-05-01

    This paper describes the results of the four NRC Inservice Testing (IST) Workshops which were held in early 1997 pertaining to NRC Inspection Procedure P 73756, Inservice Testing of Pumps and Valves. It also presents the status of the ASME code committees' resolution of certain questions forwarded to the ASME by the NRC. These questions relate to code interpretations, inconsistencies in the code, and industry concerns that are most appropriately resolved through the ASME consensus process. The ASME committees reviewed the questions at their December 1997 and March 1998 code meetings. Of particular interest are those questions for which the ASME code committees did not agree with the NRC response. These questions, as well as those which the committees provided some additional insight or input, are presented in this paper

  20. Roles of the outer membrane protein AsmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells.

    Science.gov (United States)

    Prieto, Ana I; Hernández, Sara B; Cota, Ignacio; Pucciarelli, M Graciela; Orlov, Yuri; Ramos-Morales, Francisco; García-del Portillo, Francisco; Casadesús, Josep

    2009-06-01

    A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S. enterica, suggesting that lack of AsmA activates expression of the marRAB operon. Hence, asmA mutations may enhance bile resistance by inducing gene expression changes in the marRAB-controlled Mar regulon. In silico analysis of AsmA structure predicted the existence of one transmembrane domain. Biochemical analysis of subcellular fractions revealed that the asmA gene of S. enterica encodes a protein of approximately 70 kDa located in the outer membrane. Because AsmA is unrelated to known transport and/or efflux systems, we propose that activation of marRAB in asmA mutants may be a consequence of envelope reorganization. Competitive infection of BALB/c mice with asmA(+) and asmA isogenic strains indicated that lack of AsmA attenuates Salmonella virulence by the oral route but not by the intraperitoneal route. Furthermore, asmA mutants showed a reduced ability to invade epithelial cells in vitro.

  1. Researching on knowledge architecture of design by analysis based on ASME code

    International Nuclear Information System (INIS)

    Bao Shiyi; Zhou Yu; He Shuyan

    2003-01-01

    The quality of knowledge-based system's knowledge architecture is one of decisive factors of knowledge-based system's validity and rationality. For designing the ASME code knowledge based system, this paper presents a knowledge acquisition method which is extracting knowledge through document analysis consulted domain experts' knowledge. Then the paper describes knowledge architecture of design by analysis based on the related rules in ASME code. The knowledge of the knowledge architecture is divided into two categories: one is empirical knowledge, and another is ASME code knowledge. Applied as the basement of the knowledge architecture, a general procedural process of design by analysis that is met the engineering design requirements and designers' conventional mode is generalized and explained detailed in the paper. For the sake of improving inference efficiency and concurrent computation of KBS, a kind of knowledge Petri net (KPN) model is proposed and adopted in expressing the knowledge architecture. Furthermore, for validating and verifying of the empirical rules, five knowledge validation and verification theorems are given in the paper. Moreover the research production is applicable to design the knowledge architecture of ASME codes or other engineering standards. (author)

  2. Impact of ACI-ASME code on design and construction of nuclear containment structures

    International Nuclear Information System (INIS)

    Reedy, R.F.

    1978-01-01

    The effect of the ACI-ASME code for design and construction of concrete containment structures on the nuclear and concrete industries is examined. Topics covered include purpose of the code, general requirements, responsibilities and duties, design and construction specifications, quality assurance, inspection, the liner, and stamping

  3. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis.

    NARCIS (Netherlands)

    Luger, T.; Leent, E.J. van; Graeber, M.; Hedgecock, S.; Thurston, M.; Kandra, A.; Berth-Jones, J.; Bjerke, J.; Christophers, E.; Knop, J.; Knulst, A.C.; Morren, M.; Morris, A.; Reitamo, S.; Roed-Petersen, J.; Schoepf, E.; Thestrup-Pedersen, K.; Valk, P.G.M. van der; Bos, J.D.

    2001-01-01

    BACKGROUND: SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. OBJECTIVES: This study was designed to determine

  4. Parameter subset selection for the dynamic calibration of activated sludge models (ASMs): experience versus systems analysis

    DEFF Research Database (Denmark)

    Ruano, MV; Ribes, J; de Pauw, DJW

    2007-01-01

    In this work we address the issue of parameter subset selection within the scope of activated sludge model calibration. To this end, we evaluate two approaches: (i) systems analysis and (ii) experience-based approach. The evaluation has been carried out using a dynamic model (ASM2d) calibrated...

  5. Technical justification for ASME code section xi crack detection by visual examination

    International Nuclear Information System (INIS)

    Nickell, R.E.; Rashid, Y.R.

    2001-01-01

    A critical technical element of nuclear power plant license renewal in the United States is the demonstration that the effects of aging do not compromise the intended safety function(s) of a system, structure, or component during the extended term of operation. The demonstration may take either of two forms. First, it can be shown that the design basis for the system, structure, or component is sufficiently robust that the aging effects have been insignificant through the current license term, and will continue to be insignificant through the extended term. Alternatively, it can be shown that, while the aging effects may be potentially significant, those effects can be managed and functionality maintained by defined programmatic activities during the extended term of operation. The first of the two approaches is generally provided by the construction basis, such as construction in accordance with the ASME Code Section III and other consensus codes and standards. The second of the two approaches is often provided by periodic inservice inspection and testing, in accordance with the ASME Code Section XI. The purpose of the ASME Section XI inspections and tests is to assure that systems, components, and structures are fit for continued service until the next scheduled inspection or test. The purpose of this paper is to document the effectiveness of the current ASME Code Section XI visual examination procedures in detecting the effects of aging for systems, structures, and components that are tolerant of mature cracks. (author)

  6. Reaction invariant-based reduction of the activated sludge model ASM1 for batch applications

    DEFF Research Database (Denmark)

    Santa Cruz, Judith A.; Mussati, Sergio F.; Scenna, Nicolás J.

    2016-01-01

    to batch activated sludge processes described by the Activated Sludge Model No. 1 (ASM1) for carbon and nitrogen removal. The objective of the model reduction is to describe the exact dynamics of the states predicted by the original model with a lower number of ODEs. This leads to a reduction...

  7. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis

    NARCIS (Netherlands)

    Luger, T.; van Leent, E. J.; Graeber, M.; Hedgecock, S.; Thurston, M.; Kandra, A.; Berth-Jones, J.; Bjerke, J.; Christophers, E.; Knop, J.; Knulst, A. C.; Morren, M.; Morris, A.; Reitamo, S.; Roed-Petersen, J.; Schoepf, E.; Thestrup-Pedersen, K.; van der Valk, P. G.; Bos, J. D.

    2001-01-01

    SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. This study was designed to determine the safety and efficacy

  8. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis

    NARCIS (Netherlands)

    Luger, T; Van Leent, EJM; Graeber, M; Hedgecock, S; Thurston, M; Kandra, A; Berth-Jones, J; Bjerke, J; Christophers, E; Knulst, AC; Morren, M; Morris, A; Reitamo, S; Roed-Petersen, J; Schoepf, E; Thestrup-Pedersen, K; van der Valk, P. G. M.; Bos, JD

    Background SDZ ASM 981 is a selective inhibitor of the production of pro-inflammatory cytokines from T cells and mast cells in vitro. It is the first ascomycin macrolactam derivative under development for the treatment of inflammatory skin diseases. Objectives This study was: designed to determine

  9. Simulation and optimization of a coking wastewater biological treatment process by activated sludge models (ASM).

    Science.gov (United States)

    Wu, Xiaohui; Yang, Yang; Wu, Gaoming; Mao, Juan; Zhou, Tao

    2016-01-01

    Applications of activated sludge models (ASM) in simulating industrial biological wastewater treatment plants (WWTPs) are still difficult due to refractory and complex components in influents as well as diversity in activated sludges. In this study, an ASM3 modeling study was conducted to simulate and optimize a practical coking wastewater treatment plant (CWTP). First, respirometric characterizations of the coking wastewater and CWTP biomasses were conducted to determine the specific kinetic and stoichiometric model parameters for the consecutive aeration-anoxic-aeration (O-A/O) biological process. All ASM3 parameters have been further estimated and calibrated, through cross validation by the model dynamic simulation procedure. Consequently, an ASM3 model was successfully established to accurately simulate the CWTP performances in removing COD and NH4-N. An optimized CWTP operation condition could be proposed reducing the operation cost from 6.2 to 5.5 €/m(3) wastewater. This study is expected to provide a useful reference for mathematic simulations of practical industrial WWTPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Technical report on comparative analysis of ASME QA requirements and ISO series

    International Nuclear Information System (INIS)

    Kim, Kwan Hyun

    2000-06-01

    This technical report provides the differences on the QA requirement ASME and ISO in nuclear fields. This report applies to the quality assurance(QA) programmes of the design of two requirement. The organization having overall responsibility for the nuclear design, preservation, fabrication shall be described in this report in each stage of design project

  11. Division of atomic physics

    International Nuclear Information System (INIS)

    Kroell, S.

    1994-01-01

    The Division of Atomic Physics, Lund Institute of Technology (LTH), is responsible for the basic physics teaching in all subjects at LTH and for specialized teaching in Optics, Atomic Physics, Atomic and Molecular Spectroscopy and Laser Physics. The Division has research activities in basic and applied optical spectroscopy, to a large extent based on lasers. It is also part of the Physics Department, Lund University, where it forms one of eight divisions. Since the beginning of 1980 the research activities of our division have been centred around the use of lasers. The activities during the period 1991-1992 is described in this progress reports

  12. ASM LabCap’s contributions to disease surveillance and the International Health Regulations (2005

    Directory of Open Access Journals (Sweden)

    Hakiruwizera Celestin

    2010-12-01

    Full Text Available Abstract The revised International Health Regulations [IHR(2005], which requires the Member States of the World Health Organization (WHO to develop core capacities to detect, assess, report, and respond to public health threats, is bringing new challenges for national and international surveillance systems. As more countries move toward implementation and/or strengthening of their infectious disease surveillance programs, the strengthening of clinical microbiology laboratories becomes increasingly important because they serve as the first line responders to detect new and emerging microbial threats, re-emerging infectious diseases, the spread of antibiotic resistance, and the possibility of bioterrorism. In fact, IHR(2005 Core Capacity #8, “Laboratory”, requires that laboratory services be a part of every phase of alert and response. Public health laboratories in many resource-constrained countries require financial and technical assistance to build their capacity. In recognition of this, in 2006, the American Society for Microbiology (ASM established an International Laboratory Capacity Building Program, LabCap, housed under the ASM International Board. ASM LabCap utilizes ASM’s vast resources and its membership’s expertise—40,000 microbiologists worldwide—to strengthen clinical and public health laboratory systems in low and low-middle income countries. ASM LabCap’s program activities align with HR(2005 by building the capability of resource-constrained countries to develop quality-assured, laboratory-based information which is critical to disease surveillance and the rapid detection of disease outbreaks, whether they stem from natural, deliberate or accidental causes. ASM LabCap helps build laboratory capacity under a cooperative agreement with the U.S. Centers for Disease Control and Prevention (CDC and under a sub-contract with the Program for Appropriate Technology in Health (PATH funded by the United States Agency for

  13. Interpreting ASME limits and philosophy in FEA of pressure vessel parts

    International Nuclear Information System (INIS)

    Bezerra, L.M.; Cruz, J.R.B.; Miranda, C.A.J.; Neto, M.M.

    1995-01-01

    In recent years there has been an effort to interpret finite element (FE) stress results on the light of the ASME B and PV rules and philosophy. Many task groups have issued guidelines on stress linearization and classifications. All those attempts have come up trying to cope modern FE techniques with the rules imposed by the ASME Code. This paper is an independent contribution to the Pressure Vessel Research Council (PVRC) groups which are studying the stress classification and the failure mechanism in a FE framework. This work tries to complement the interesting work by Hollinger and Hechmer presented in the PVP-94 in Minneapolis. In that paper, the authors examined a typical support skirt and showed relations between the skirt collapse load obtained by finite element analysis and the loads allowed from the ASME stress limits. To complement such paper, in the present article, different skirt geometry configurations are analyzed. The configurations here investigated consist of similar support skirts but with different angles of attachments between cylinder and cone parts. It will be possible to observe the influence of the bending stress in the collapse load and its relation to the allowable loads inferred from the ASME limits. A pressure vessel with torispherical head under internal pressure is also examined. Using elastic and limit load FEA, the present paper determines the collapse loads of the configurations. It sets up the relations between these collapse loads, stress categories, and limits dictated by the ASME Code Subsection NB. On the light of NB rules and philosophy, this paper shows how different methods of stress assessment, classification, and limits may influence in the design of a pressure vessel

  14. Statistical analysis of geomagnetic field intensity differences between ASM and VFM instruments onboard Swarm constellation

    Science.gov (United States)

    De Michelis, Paola; Tozzi, Roberta; Consolini, Giuseppe

    2017-02-01

    From the very first measurements made by the magnetometers onboard Swarm satellites launched by European Space Agency (ESA) in late 2013, it emerged a discrepancy between scalar and vector measurements. An accurate analysis of this phenomenon brought to build an empirical model of the disturbance, highly correlated with the Sun incidence angle, and to correct vector data accordingly. The empirical model adopted by ESA results in a significant decrease in the amplitude of the disturbance affecting VFM measurements so greatly improving the vector magnetic data quality. This study is focused on the characterization of the difference between magnetic field intensity measured by the absolute scalar magnetometer (ASM) and that reconstructed using the vector field magnetometer (VFM) installed on Swarm constellation. Applying empirical mode decomposition method, we find the intrinsic mode functions (IMFs) associated with ASM-VFM total intensity differences obtained with data both uncorrected and corrected for the disturbance correlated with the Sun incidence angle. Surprisingly, no differences are found in the nature of the IMFs embedded in the analyzed signals, being these IMFs characterized by the same dominant periodicities before and after correction. The effect of correction manifests in the decrease in the energy associated with some IMFs contributing to corrected data. Some IMFs identified by analyzing the ASM-VFM intensity discrepancy are characterized by the same dominant periodicities of those obtained by analyzing the temperature fluctuations of the VFM electronic unit. Thus, the disturbance correlated with the Sun incidence angle could be still present in the corrected magnetic data. Furthermore, the ASM-VFM total intensity difference and the VFM electronic unit temperature display a maximal shared information with a time delay that depends on local time. Taken together, these findings may help to relate the features of the observed VFM-ASM total intensity

  15. Computational Fair Division

    DEFF Research Database (Denmark)

    Branzei, Simina

    Fair division is a fundamental problem in economic theory and one of the oldest questions faced through the history of human society. The high level scenario is that of several participants having to divide a collection of resources such that everyone is satisfied with their allocation -- e.g. two...... heirs dividing a car, house, and piece of land inherited. The literature on fair division was developed in the 20th century in mathematics and economics, but computational work on fair division is still sparse. This thesis can be seen as an excursion in computational fair division divided in two parts....... The first part tackles the cake cutting problem, where the cake is a metaphor for a heterogeneous divisible resource such as land, time, mineral deposits, and computer memory. We study the equilibria of classical protocols and design an algorithmic framework for reasoning about their game theoretic...

  16. Case study of the propagation of a small flaw under PWR loading conditions and comparison with the ASME code design life. Comparison of ASME Code Sections III and XI

    International Nuclear Information System (INIS)

    Yahr, G.T.; Gwaltney, R.C.; Richardson, A.K.; Server, W.L.

    1986-01-01

    A cooperative study was performed by EG and G Idaho, Inc., and Oak Ridge National Laboratory to investigate the degree of conservatism and consistency in the ASME Boiler and Pressure Vessel Code Section III fatigue evaluation procedure and Section XI flaw acceptance standards. A single, realistic, sample problem was analyzed to determine the significance of certain points of criticism made of an earlier parametric study by staff members of the Division of Engineering Standards of the Nuclear Regulatory Commission. The problem was based on a semielliptical flaw located on the inside surface of the hot-leg piping at the reactor vessel safe-end weld for the Zion 1 pressurized-water reactor (PWR). Two main criteria were used in selecting the problem; first, it should be a straight pipe to minimize the computational expense; second, it should exhibit as high a cumulative usage factor as possible. Although the problem selected has one of the highest cumulative usage factors of any straight pipe in the primary system of PWRs, it is still very low. The Code Section III fatigue usage factor was only 0.00046, assuming it was in the as-welded condition, and fatigue crack-growth analyses predicted negligible crack growth during the 40-year design life. When the analyses were extended past the design life, the usage factor was less than 1.0 when the flaw had propagated to failure. The current study shows that the criticism of the earlier report should not detract from the conclusion that if a component experiences a high level of cyclic stress corresponding to a fatigue usage factor near 1.0, very small cracks can propagate to unacceptable sizes

  17. 1:N Space Division Switches for Optical Routing, Reconfigurable Interconnections, and Time and Wavelength-Division Switching Applications

    National Research Council Canada - National Science Library

    Shire, D

    1998-01-01

    ... of time-division multiplexing and demultiplexing operations. Hysteresis in the input-output transfer characteristics of the coupled in-plane lasers and VCSELs also leads to bistable operation over a range of bias conditions...

  18. Divisible ℤ-modules

    Directory of Open Access Journals (Sweden)

    Futa Yuichi

    2016-03-01

    Full Text Available In this article, we formalize the definition of divisible ℤ-module and its properties in the Mizar system [3]. We formally prove that any non-trivial divisible ℤ-modules are not finitely-generated.We introduce a divisible ℤ-module, equivalent to a vector space of a torsion-free ℤ-module with a coefficient ring ℚ. ℤ-modules are important for lattice problems, LLL (Lenstra, Lenstra and Lovász base reduction algorithm [15], cryptographic systems with lattices [16] and coding theory [8].

  19. Parametric study of emerging high power accelerator applications using Accelerator Systems Model (ASM)

    International Nuclear Information System (INIS)

    Berwald, D.H.; Mendelsohn, S.S.; Myers, T.J.; Paulson, C.C.; Peacock, M.A.; Piaszczyk, CM.; Rathke, J.W.; Piechowiak, E.M.

    1996-01-01

    Emerging applications for high power rf linacs include fusion materials testing, generation of intense spallation neutrons for neutron physics and materials studies, production of nuclear materials and destruction of nuclear waste. Each requires the selection of an optimal configuration and operating parameters for its accelerator, rf power system and other supporting subsystems. Because of the high cost associated with these facilities, economic considerations become paramount, dictating a full evaluation of the electrical and rf performance, system reliability/availability, and capital, operating, and life cycle costs. The Accelerator Systems Model (ASM), expanded and modified by Northrop Grumman during 1993-96, provides a unique capability for detailed layout and evaluation of a wide variety of normal and superconducting accelerator and rf power configurations. This paper will discuss the current capabilities of ASM, including the available models and data base, and types of trade studies that can be performed for the above applications. (author)

  20. Comparisons of ratchetting analysis methods using RCC-M, RCC-MR and ASME codes

    International Nuclear Information System (INIS)

    Yang Yu; Cabrillat, M.T.

    2005-01-01

    The present paper compares the simplified ratcheting analysis methods used in RCC-M, RCC-MR and ASME with some examples. Firstly, comparisons of the methods in RCC-M and efficiency diagram in RCC-MR are investigated. A special method is used to describe these two methods with curves in one coordinate, and the different conservation is demonstrated. RCC-M method is also be interpreted by SR (second ratio) and v (efficiency index) which is used in RCC-MR. Hence, we can easily compare the previous two methods by defining SR as abscissa and v as ordinate and plotting two curves of them. Secondly, comparisons of the efficiency curve in RCC-MR and methods in ASME-NH APPENDIX T are investigated, with significant creep. At last, two practical evaluations are performed to show the comparisons of aforementioned methods. (authors)

  1. Design and test of ASME strainer for primary cooling system in HANARO

    International Nuclear Information System (INIS)

    Park, Yong-Chul; Ryu, Jeong-Soo

    1999-01-01

    The ASME strainers have been newly installed at the suction side of each reactor coolant pump to get rid of the foreign materials which may damage the pump impeller or interfere with the coolant path of fuel flow tube or primary plate type heat exchanger. The strainer was designed in accordance with ASME SEC. III, DIV. 1, ND and the structural integrity was verified by seismic analysis. The screen was designed in accordance with the effective void area from the result of flow analysis for T-type strainer. After installation of the strainer, it was confirmed through the field test that the flow characteristics of primary cooling system were not adversely affected. The pressure loss coefficient was calculated by Darcy equation using the pressure difference through each strainer and the flow rate measured during the strainer performance test. And these are useful data to predict flow variations by the pressure difference. (author)

  2. Extended activated sludge model no. 1 (ASM1 for simulating biodegradation process using bacterial technology

    Directory of Open Access Journals (Sweden)

    Ya-jing Song

    2012-09-01

    Full Text Available Phosphorus is one of the most important nutrients required to support various kinds of biodegradation processes. As this particular nutrient is not included in the activated sludge model no. 1 (ASM1, this study extended this model in order to determine the fate of phosphorus during the biodegradation processes. When some of the kinetics parameters are modified using observed data from the restoration project of the Xuxi River in Wuxi City, China, from August 25 to 31 in 2009, the extended model shows excellent results. In order to obtain optimum values of coefficients of nitrogen and phosphorus, the mass fraction method was used to ensure that the final results were reasonable and practically relevant. The temporal distribution of the data calculated with the extended ASM1 approximates that of the observed data.

  3. Underwater Sound Reference Division

    Data.gov (United States)

    Federal Laboratory Consortium — The Underwater Sound Reference Division (USRD) serves as the U.S. standardizing activity in the area of underwater acoustic measurements, as the National Institute...

  4. On Geometric Infinite Divisibility

    OpenAIRE

    Sandhya, E.; Pillai, R. N.

    2014-01-01

    The notion of geometric version of an infinitely divisible law is introduced. Concepts parallel to attraction and partial attraction are developed and studied in the setup of geometric summing of random variables.

  5. Theoretical physics division

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    Research activities of the theoretical physics division for 1979 are described. Short summaries are given of specific research work in the following fields: nuclear structure, nuclear reactions, intermediate energy physics, elementary particles [fr

  6. Appropriate nominal stresses for use with ASME Code pressure-loading stress indices for nozzles

    International Nuclear Information System (INIS)

    Rodabaugh, E.C.

    1976-06-01

    This program is part of a cooperative effort with industry to develop and verify analytical methods for assessing the safety of nuclear pressure-vessel and piping-system design. The study of nominal stresses and stress indices described is part of a continuing study of design rules for nozzles in pressure vessels being coordinated by the PVRC Subcommittee on Reinforced Openings and External Loadings. Results from these studies are used by appropriate ASME Code groups in drafting new and improved design rules

  7. The control of safety allowance for nuclear power plant components in ASME-BPVC

    International Nuclear Information System (INIS)

    Yao Weida; Ning Dong; Yang Ren'an; He Yinbiao; Xie Yongcheng; Zhang Ming; Yao Yangui

    2011-01-01

    How to control the 'safety allowance' reasonably at each phase of materials, design, fabrication, test, examination, building, pre-service and in-service operation and others in ASME-BPVC was preliminarily discussed. The two quantitative requirements of 'safety factor' and 'acceptance criteria' were dissected. The responsibilities of controlled documents and personnel to assure 'safety allowance' were also represented. (authors)

  8. Report on ANSI/ASME nuclear air and gas treatment standards for nuclear power plants

    International Nuclear Information System (INIS)

    Fish, J.F.

    1979-01-01

    Original N Committee, N45-8, has completed and published through the approved American National Standards Institute process two Standards, N-509 and N-510. This committee has been dissolved and replaced by ASME Committee on Nuclear Air and Gas Treatment with expanded scope to cover not only air cleaning, but thermal treatment equipment. Current efforts are directed to produce Code documents rather than Standards type publications. This report summarizes changed scope, current organization and sub-committee coverage areas

  9. Meeting report on the ASM Conference on Mechanisms of Interbacterial Cooperation and Competition.

    Science.gov (United States)

    Lories, Bram; Parijs, Ilse; Foster, Kevin R; Steenackers, Hans P

    2017-08-14

    The ASM Conference on Mechanisms of Interbacterial Cooperation and Competition was held in Washington DC, from 1 to 4 March 2017. The conference provided an international forum for sociomicrobiologists from different disciplines to present and discuss new findings. The meeting covered a wide range of topics, spanning molecular mechanisms, ecology, evolution, computation and manipulation of interbacterial interactions, and encompassed social communities in medicine, the natural environment, and industry. This report summarizes the presentations and emerging themes. Copyright © 2017 American Society for Microbiology.

  10. Division Level Social Media

    Science.gov (United States)

    2015-06-12

    consumes, and the disparity of demographics at the division level. Organic reach across Facebook is decreasing due to more paid advertisements and...U.S. Army units of all sizes have their own social media pages on Facebook , Instagram, Twitter, or a combination of all three sites. Social media...TERMS Division, Facebook , Internet, Social Media 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME

  11. The Cadre Division

    Science.gov (United States)

    1992-05-20

    NAME OF MONITORING ORGANIZATION U.S. Army War College (if & pika ble) Carlisle Barracks I 6c. ADDRESS (City, State, and ZIP Code) 7b. ADDRESS (City...divisions in the shortest possible time with the smallest feasible cost to the American taxpayer. This concept puts a cadre of active and reserve soldiers in...fighting divisions in the shortest possible time with the smallest feasible cost to the American taxpayer. This concept puts a cadre of active and

  12. RXTE ASM Observations of GRB991216 - A One Hour Old X-ray Afterglow

    Science.gov (United States)

    Corbet, R.; Smith, D. A.

    The Gamma-ray Burst 991216 (the ``Beethoven" burst) was both very bright itself and also had an unusually bright X-ray afterglow. This afterglow was observed and localized by the RXTE PCA 4 hours after the burst occurred (Takeshima et al. 1999). This position determination then enabled an optical afterglow to be found (Uglesich et al 1999). Serendipitously, the RXTE ASM obtained a sequence of 7 observations covering this source in a period of 11 minutes starting just 1 hour after the burst peak. From these 7 dwells, a flux of 32 +/- 8 mCrabs (1 sigma error) was determined which is consistent with a power-law extrapolation of RXTE PCA flux measurements. While GRB afterglows are generally faint and thus difficult for the RXTE ASM to study, due to its modest collecting area and short observation times, we believe that this unusually bright afterglow has indeed been detected. These results indicate that the RXTE ASM has provided a measurement of an X-ray afterglow light curve at times which have previously not been studied.

  13. Modification of the ASME code z-factor for circumferential surface crack in nuclear ferritic pipings

    International Nuclear Information System (INIS)

    Choi, Young Hwan; Chung, Yon Ki; Koh, Wan Young; Lee, Joung Bae

    1996-01-01

    The purpose of this paper is to modify the ASME Code Z-Factor, which is used in the evaluation of circumferential surface crack in nuclear ferritic pipings. The ASME Code Z-Factor is a load multiplier to compensate plastic load with elasto-plastic load. The current ASME Code Z-Factor underestimates pipe maximum load. In this study, the original SC. TNP method is modified first because the original SC. TNP method has a problem that the maximum allowable load predicted from the original SC. TNP method is slightly higher than that measured from the experiment. Then the new Z-Factor is developed using the modified SC. TNP method. The desirability of both the modified SC. TNP method and the new Z-Factor is examined using the experimental results for the circumferential surface crack in pipings. The results show that (1) the modified SC. TNP method is good for predicting the circumferential surface crack behavior in pipings, and (2) the Z-Factor obtained from the modified SC. TNP method well predicts the behavior of circumferential surface crack in ferritic pipings. 30 refs., 13 figs., 4 tabs. (author)

  14. Linearization of the activated sludge model ASM1 for fast and reliable predictions.

    Science.gov (United States)

    Smets, Ilse Y; Haegebaert, Jeroen V; Carrette, Ronald; Van Impe, Jan F

    2003-04-01

    In this paper a strategy is proposed to reduce the complexity of the activated sludge model no. 1 (ASM1) which describes the biotransformation processes in a common activated sludge process with N-removal. The key feature of the obtained reduced model is that it combines high predictive value (all state variables keep their biological interpretation) with very low computation time. Therefore, this model is a valuable tool in a risk assessment environment (designed for the evaluation of wastewater treatment plants facing stricter effluent norms) as well as in on-line (MPC) control strategies. The complexity reduction procedure consists of four steps. In the first step representative input/output data sets are generated by simulating the full ASM1 model. In the second step the ASM1 model is rewritten in state space format with linear approximations of the nonlinear (kinetic) terms. In the third step the unknown parameters in the linear terms are identified based on the generated input/output data. To reduce the amount of parameter sets that have to be identified (to cover the full operation range of the plant), a Multi-Model interpolation procedure is introduced as a last step.

  15. Comparison of SKIFS 2004:1 and Tillsynshandbok PSA against the ASME PRA Standard and European requirements on PSA; Jaemfoerelse av SKIFS 2004:1 och Tillsynshandbok PSA mot ASME PRA Standard och Europeiska krav paa PSA

    Energy Technology Data Exchange (ETDEWEB)

    Hellstroem, Per

    2005-04-15

    Requirements on PSA for risk informed applications are expressed in different international documents. The ASME PRA standard published in spring 2002 is one such document, PSA requirements are also expressed in the European Utility Requirements (EUR) for new reactors. The Swedish PSA requirements are provided in the Swedish regulators (SKI) statutes SKIFS 2004:1. SKI also has a review handbook for PSA activities (SKI report 2003:48). The review handbook is a support during review of the utilities PSA activities and the PSAs themselves. The review handbook expresses SKIs expectations by providing so called important aspects for both the PSA work and the PSAs, A comparison of SKIFS requirements and the important aspects in the Review handbook, on one side, and the requirements on PSA in EUR and ASME on the other side, is presented. The comparison shows a large difference in the level of detail in the different documents, where ASME is most detailed and specific. This is expected since the SKI review handbook not is a 'PSA guide' in the same way as the ASME PRA standard. A direct comparison of the ASME PRA standard requirements with the important aspects in the review handbook cannot answer the question which ASME capacity level that is achieved by a PSA meeting all important aspects. The conclusion is that it is not likely to achieve capacity level 2 and 3, since very few ASME level 3 attributes are explicitly expressed as important aspects, though many are expressed in general terms. The review handbook important aspects that are most similar to the ASME capacity level 1 attributes are initiating events, sequence analysis, and system analysis while less similarity is found for analysis of operator actions data analysis, quantification and containment analysis (level 2). Less similarity is found for capacity level 2 and 3. However, the number of additional ASME attributes on capacity level 2 and 3 are few. There are also important aspects in the review

  16. GC-ASM: Synergistic Integration of Graph-Cut and Active Shape Model Strategies for Medical Image Segmentation.

    Science.gov (United States)

    Chen, Xinjian; Udupa, Jayaram K; Alavi, Abass; Torigian, Drew A

    2013-05-01

    Image segmentation methods may be classified into two categories: purely image based and model based. Each of these two classes has its own advantages and disadvantages. In this paper, we propose a novel synergistic combination of the image based graph-cut (GC) method with the model based ASM method to arrive at the GC-ASM method for medical image segmentation. A multi-object GC cost function is proposed which effectively integrates the ASM shape information into the GC framework. The proposed method consists of two phases: model building and segmentation. In the model building phase, the ASM model is built and the parameters of the GC are estimated. The segmentation phase consists of two main steps: initialization (recognition) and delineation. For initialization, an automatic method is proposed which estimates the pose (translation, orientation, and scale) of the model, and obtains a rough segmentation result which also provides the shape information for the GC method. For delineation, an iterative GC-ASM algorithm is proposed which performs finer delineation based on the initialization results. The proposed methods are implemented to operate on 2D images and evaluated on clinical chest CT, abdominal CT, and foot MRI data sets. The results show the following: (a) An overall delineation accuracy of TPVF > 96%, FPVF segmentation step compared to GC which requires seed specification and improves on the accuracy of GC. (e) One disadvantage of GC-ASM is its increased computational expense owing to the iterative nature of the algorithm.

  17. Densidade Mineral Óssea em Mulheres Asmáticas, na Fase Perimenopausa

    Directory of Open Access Journals (Sweden)

    Anne K. Laatikainen

    1999-07-01

    Full Text Available RESUMO: Os corticóides inalados, constituem a terapêutica anti-inflamatória de eleição, utilizada nos asmáticos, por longos penodos.Para além dos corticóides inalados utilizados como terapêutica preventiva, a corticoterapia oral e endovenosa é por vezes necessária nos períodos de exacerbação da doença.É bem conhecido o risco de osteoporose em doentes com asma grave medicados com corticoterapta oral a longo prazo O efeito dos corticóides inalados a nivel da densidade óssea, não é bem conhecido, pelo que tem sido alvo de estudos recentes.A menopausa é considerada o principal factor de risco da osteoporose. Ainda não é bem conhecido qual o papel da asma como factor de risco de ostcoporose equal o impacto dos corticóides inalados na densitometria óssea.Os autores procederam a urn estudo inicialmente dingido a uma população de 14220 mulheres dos 47 aos 56 anos de idade (período perimenopausa, residentes na Província de Kuopio, no Leste da Finlândia.Foi enviado urn inquérito incluindo a história ginecológica, uso de terapêutica hormonal de substituição, paridade, peso, altura, actividade fisica, consumo de produtos lácteos, hábitos tabágicos, morbilidade e teraêuticas habituais. Houve resposta em 84 4% dos inquiridos.Foi realizada osteodensitometria óssea (BMD do colo do fémur esquerdo e coluna em 3222 mulheres, de acordo com um estudo randomizado simples, estratificado.Após exclusão de alguns registos considerados inválidos, a população estudada consistia em 2941 mulheres, das quais 119 eram asmáticas. A estas foi feito um inquérito adicional acerca do uso de cortticóides, dose diária, duração e regularidade.Os autores verificaram que 72 doentes (60.5% estavam medicadas com corticóides inalados. Dez asmáticas faziam regularmente corticoterapia oral. Em 61 doentes havia referência a pelo menos um curso de corticóide oral nos últimos 6 meses. Vinte e oito asmáticas nunca tinham feito terap

  18. Understanding the Long-Term Spectral Variability of Cygnus X-1 from BATSE and ASM Observations

    Science.gov (United States)

    Zdziarski, Andrzej A.; Poutanen, Juri; Paciesas, William S.; Wen, Linqing; Six, N. Frank (Technical Monitor)

    2002-01-01

    We present a spectral analysis of observations of Cygnus X-1 by the RXTE/ASM (1.5-12 keV) and CGRO/BATSE (20-300 keV), including about 1200 days of simultaneous data. We find a number of correlations between intensities and hardnesses in different energy bands from 1.5 keV to 300 keV. In the hard (low) spectral state, there is a negative correlation between the ASM 1.5-12 keV flux and the hardness at any energy. In the soft (high) spectral state, the ASM flux is positively correlated with the ASM hardness (as previously reported) but uncorrelated with the BATSE hardness. In both spectral states, the BATSE hardness correlates with the flux above 100 keV, while it shows no correlation with the flux in the 20-100 keV range. At the same time, there is clear correlation between the BATSE fluxes below and above 100 keV. In the hard state, most of the variability can be explained by softening the overall spectrum with a pivot at approximately 50 keV. The observations show that there has to be another, independent variability pattern of lower amplitude where the spectral shape does not change when the luminosity changes. In the soft state, the variability is mostly caused by a variable hard (Comptonized) spectral component of a constant shape superimposed on a constant soft blackbody component. These variability patterns are in agreement with the dependence of the rms variability on the photon energy in the two states. We interpret the observed correlations in terms of theoretical Comptonization models. In the hard state, the variability appears to be driven mostly by changing flux in seed photons Comptonized in a hot thermal plasma cloud with an approximately constant power supply. In the soft state, the variability is consistent with flares of hybrid, thermal/nonthermal, plasma with variable power above a stable cold disk. Also, based on broadband pointed observations simultaneous with those of the ASM and BATSE, we find the intrinsic bolometric luminosity increases by a

  19. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.

    Directory of Open Access Journals (Sweden)

    Yongsoon Kim

    Full Text Available In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals.

  20. ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target

    Science.gov (United States)

    Kim, Yongsoon; Sun, Hong

    2012-01-01

    In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS) pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals. PMID:23049887

  1. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.

    Science.gov (United States)

    Kim, Yongsoon; Sun, Hong

    2012-01-01

    In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor signaling (IIS) pathway regulates longevity, metabolism, reproduction and development. In mammals, acid sphingomyelinase (ASM) is an enzyme that hydrolyzes sphingomyelin to produce ceramide. ASM has been implicated in CD95 death receptor signaling under certain stress conditions. However, the involvement of ASM in growth factor receptor signaling under physiological conditions is not known. Here, we report that in vivo ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans. We have shown that inactivation of asm-3 extends animal lifespan and promotes dauer arrest, an alternative developmental process. A significant cooperative effect on lifespan is observed between asm-3 deficiency and loss-of-function alleles of the age-1/PI 3-kinase, with the asm-3; age-1 double mutant animals having a mean lifespan 259% greater than that of the wild-type animals. The lifespan extension phenotypes caused by the loss of asm-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN. We have demonstrated that inactivation of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targeting genes of DAF-16. Together, our findings reveal a novel role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway. Importantly, we have found that two drugs known to inhibit mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type animals, in a manner similar to that achieved by genetic inactivation of the asm genes. Our studies illustrate a novel strategy of anti-aging by targeting ASM, which may potentially be extended to mammals.

  2. Theoretical Division progress report

    International Nuclear Information System (INIS)

    Cooper, N.G.

    1979-04-01

    This report presents highlights of activities in the Theoretical (T) Division from October 1976-January 1979. The report is divided into three parts. Part I presents an overview of the Division: its unique function at the Los Alamos Scientific Laboratory (LASL) and within the scientific community as a whole; the organization of personnel; the main areas of research; and a survey of recent T-Division initiatives. This overview is followed by a survey of the 13 groups within the Division, their main responsibilities, interests, and expertise, consulting activities, and recent scientific accomplisments. The remainder of the report, Parts II and III, is devoted to articles on selected research activities. Recent efforts on topics of immediate interest to energy and weapons programs at LASL and elsewhere are described in Part II, Major National Programs. Separate articles present T-Divison contributions to weapons research, reactor safety and reactor physics research, fusion research, laser isotope separation, and other energy research. Each article is a compilation of independent projects within T Division, all related to but addressing different aspects of the major program. Part III is organized by subject discipline, and describes recent scientific advances of fundamental interest. An introduction, defining the scope and general nature of T-Division efforts within a given discipline, is followed by articles on the research topics selected. The reporting is done by the scientists involved in the research, and an attempt is made to communicate to a general audience. Some data are given incidentally; more technical presentations of the research accomplished may be found among the 47 pages of references. 110 figures, 5 tables

  3. Power Dissipation in Division

    DEFF Research Database (Denmark)

    Liu, Wei; Nannarelli, Alberto

    2008-01-01

    A few classes of algorithms to implement division in hardware have been used over the years: division by digit-recurrence, by reciprocal approximation by iterative methods and by polynomial approximation. Due to the differences in the algorithms, a comparison among their implementation in terms o...... of performance and precision is sometimes hard to make. In this work, we use power dissipation and energy consumption as metrics to compare among those different classes of algorithms. There are no previous works in the literature presenting such a comparison....

  4. Digital Arithmetic: Division Algorithms

    DEFF Research Database (Denmark)

    Montuschi, Paolo; Nannarelli, Alberto

    2017-01-01

    implement it in hardware to not compromise the overall computation performances. This entry explains the basic algorithms, suitable for hardware and software, to implement division in computer systems. Two classes of algorithms implement division or square root: digit-recurrence and multiplicative (e.......g., Newton–Raphson) algorithms. The first class of algorithms, the digit-recurrence type, is particularly suitable for hardware implementation as it requires modest resources and provides good performance on contemporary technology. The second class of algorithms, the multiplicative type, requires...

  5. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma.

    Directory of Open Access Journals (Sweden)

    Evelyne Israël Assayag

    Full Text Available Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP, has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg. The methacholine ED250 values indicated that airway hyperresponsivenness (AHR to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145 ± 0.032 mg/kg for ASM 024-treated group as compared to 0.088 ± 0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD.

  6. Neurospora crassa ASM-1 complements the conidiation defect in a stuA mutant of Aspergillus nidulans.

    Science.gov (United States)

    Chung, Dawoon; Upadhyay, Srijana; Bomer, Brigitte; Wilkinson, Heather H; Ebbole, Daniel J; Shaw, Brian D

    2015-01-01

    Aspergillus nidulans StuA and Neurospora crassa ASM-1 are orthologous APSES (ASM-1, PHD1, SOK2, Efg1, StuA) transcription factors conserved across a diverse group of fungi. StuA and ASM-1 have roles in asexual (conidiation) and sexual (ascospore formation) development in both organisms. To address the hypothesis that the last common ancestor of these diverse fungi regulated conidiation with similar genes, asm-1 was introduced into the stuA1 mutant of A. nidulans. Expression of asm-1 complemented defective conidiophore morphology and restored conidia production to wild type levels in stuA1. Expression of asm-1 in the stuA1 strain did not rescue the defect in sexual development. When the conidiation regulator AbaA was tagged at its C-terminus with GFP in A. nidulans, it localized to nuclei in phialides. When expressed in the stuA1 mutant, AbaA::GFP localized to nuclei in conidiophores but no longer was confined to phialides, suggesting that expression of AbaA in specific cell types of the conidiophore was conditioned by StuA. Our data suggest that the function in conidiation of StuA and ASM-1 is conserved and support the view that, despite the great morphological and ontogenic diversity of their condiphores, the last common ancestor of A. nidulans and N. crassa produced an ortholog of StuA that was involved in conidiophore development. © 2015 by The Mycological Society of America.

  7. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma.

    Science.gov (United States)

    Assayag, Evelyne Israël; Beaulieu, Marie-Josée; Cormier, Yvon

    2014-01-01

    Conventional asthma and COPD treatments include the use of bronchodilators, mainly β2-adrenergic agonists, muscarinic receptor antagonists and corticosteroids or leukotriene antagonists as anti-inflammatory agents. These active drugs are administered either separately or given as a fixed-dose combination medication into a single inhaler. ASM-024, a homopiperazinium compound, derived from the structural modification of diphenylmethylpiperazinium (DMPP), has been developed to offer an alternative mechanism of action that could provide symptomatic control through combined anti-inflammatory and bronchodilator properties in a single entity. A dose-dependent inhibition of cellular inflammation in bronchoalveolar lavage fluid was observed in ovalbumin-sensitized mice, subsequently treated for 3 days by nose-only exposure with aerosolized ASM-024 at doses up to 3.8 mg/kg (ED50 = 0.03 mg/kg). The methacholine ED250 values indicated that airway hyperresponsivenness (AHR) to methacholine decreased following ASM-024 administration by inhalation at a dose of 1.5 mg/kg, with a value of 0.145 ± 0.032 mg/kg for ASM 024-treated group as compared to 0.088 ± 0.023 mg/kg for untreated mice. In in vitro isometric studies, ASM-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. ASM-024 showed also a dose and time dependant protective effect on methacholine-induced contraction. Overall, with its combined anti-inflammatory, bronchodilating and bronchoprotective properties, ASM-024 may represent a new class of drugs with a novel pharmacological approach that could prove useful for the chronic maintenance treatment of asthma and, possibly, COPD.

  8. Solid State Division

    International Nuclear Information System (INIS)

    Green, P.H.; Watson, D.M.

    1989-08-01

    This report contains brief discussions on work done in the Solid State Division of Oak Ridge National Laboratory. The topics covered are: Theoretical Solid State Physics; Neutron scattering; Physical properties of materials; The synthesis and characterization of materials; Ion beam and laser processing; and Structure of solids and surfaces

  9. Solid State Division

    Energy Technology Data Exchange (ETDEWEB)

    Green, P.H.; Watson, D.M. (eds.)

    1989-08-01

    This report contains brief discussions on work done in the Solid State Division of Oak Ridge National Laboratory. The topics covered are: Theoretical Solid State Physics; Neutron scattering; Physical properties of materials; The synthesis and characterization of materials; Ion beam and laser processing; and Structure of solids and surfaces. (LSP)

  10. Theoretical Physics Division

    International Nuclear Information System (INIS)

    This report is a survey of the studies done in the Theoretical Physics Division of the Nuclear Physics Institute; the subjects studied in theoretical nuclear physics were the few-nucleon problem, nuclear structure, nuclear reactions, weak interactions, intermediate energy and high energy physics. In this last field, the subjects studied were field theory, group theory, symmetry and strong interactions [fr

  11. THE SPRINGBOK SIXTH DIVISION

    African Journals Online (AJOL)

    The Springboks showed the enemy that they were on the ball. On Lordly Mont' Sorrate they trained their ... From peak to peak in front of them the message was relayed. By the Reichsfuehrer Division, the SS corps d' ... Between the Sixth Div front line and the German rock-bound lair. Lay a sinister stretch of no-man's land of ...

  12. On infinitely divisible semimartingales

    DEFF Research Database (Denmark)

    Basse-O'Connor, Andreas; Rosiński, Jan

    2015-01-01

    processes, including linear fractional processes, mixed moving averages, and supOU processes, as particular cases. The proof of the main theorem relies on series representations of jumps of cadlag infinitely divisible processes given in Basse-O'Connor and Rosinski [2013, Ann. Probab. 41(6)] combined...... with techniques of stochastic analysis....

  13. The ASM-NSF Biology Scholars Program: An Evidence-Based Model for Faculty Development

    Directory of Open Access Journals (Sweden)

    Amy L. Chang

    2016-05-01

    Full Text Available The American Society for Microbiology (ASM established its ASM-NSF (National Science Foundation Biology Scholars Program (BSP to promote undergraduate education reform by 1 supporting biologists to implement evidence-based teaching practices, 2 engaging life science professional societies to facilitate biologists’ leadership in scholarly teaching within the discipline, and 3 participating in a teaching community that fosters disciplinary-level science, technology, engineering, and mathematics (STEM reform. Since 2005, the program has utilized year-long residency training to provide a continuum of learning and practice centered on principles from the scholarship of teaching and learning (SoTL to more than 270 participants (“scholars” from biology and multiple other disciplines. Additionally, the program has recruited 11 life science professional societies to support faculty development in SoTL and discipline-based education research (DBER. To identify the BSP’s long-term outcomes and impacts, ASM engaged an external evaluator to conduct a study of the program’s 2010­–2014 scholars (n = 127 and society partners. The study methods included online surveys, focus groups, participant observation, and analysis of various documents. Study participants indicate that the program achieved its proposed goals relative to scholarship, professional society impact, leadership, community, and faculty professional development. Although participants also identified barriers that hindered elements of their BSP participation, findings suggest that the program was essential to their development as faculty and provides evidence of the BSP as a model for other societies seeking to advance undergraduate science education reform. The BSP is the longest-standing faculty development program sponsored by a collective group of life science societies. This collaboration promotes success across a fragmented system of more than 80 societies representing the life

  14. The ASM-NSF Biology Scholars Program: An Evidence-Based Model for Faculty Development.

    Science.gov (United States)

    Chang, Amy L; Pribbenow, Christine M

    2016-05-01

    The American Society for Microbiology (ASM) established its ASM-NSF (National Science Foundation) Biology Scholars Program (BSP) to promote undergraduate education reform by 1) supporting biologists to implement evidence-based teaching practices, 2) engaging life science professional societies to facilitate biologists' leadership in scholarly teaching within the discipline, and 3) participating in a teaching community that fosters disciplinary-level science, technology, engineering, and mathematics (STEM) reform. Since 2005, the program has utilized year-long residency training to provide a continuum of learning and practice centered on principles from the scholarship of teaching and learning (SoTL) to more than 270 participants ("scholars") from biology and multiple other disciplines. Additionally, the program has recruited 11 life science professional societies to support faculty development in SoTL and discipline-based education research (DBER). To identify the BSP's long-term outcomes and impacts, ASM engaged an external evaluator to conduct a study of the program's 2010-2014 scholars (n = 127) and society partners. The study methods included online surveys, focus groups, participant observation, and analysis of various documents. Study participants indicate that the program achieved its proposed goals relative to scholarship, professional society impact, leadership, community, and faculty professional development. Although participants also identified barriers that hindered elements of their BSP participation, findings suggest that the program was essential to their development as faculty and provides evidence of the BSP as a model for other societies seeking to advance undergraduate science education reform. The BSP is the longest-standing faculty development program sponsored by a collective group of life science societies. This collaboration promotes success across a fragmented system of more than 80 societies representing the life sciences and helps

  15. ASME N510 test results for Savannah River Site AACS filter compartments

    Energy Technology Data Exchange (ETDEWEB)

    Paul, J.D.; Punch, T.M. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1995-02-01

    The K-Reactor at the Savannah River Site recently implemented design improvements for the Airborne Activity Confinement System (AACS) by procuring, installing, and testing new Air Cleaning Units, or filter compartments, to ASME AG-11, N509, and N510 requirements. Specifically, these new units provide documentable seismic resistance to a Design Basis Accident earthquake, provide 2 inch adsorber beds with 0.25 second residence time, and meet all AG-1, N509, and N510 requirements for testability and maintainability. This paper presents the results of the Site acceptance testing and discusses an issue associated with sample manifold qualification testing.

  16. ASTM and ASME-BPE Standards--Complying with the Needs of the Pharmaceutical Industry.

    Science.gov (United States)

    Huitt, William M

    2011-01-01

    Designing and building a pharmaceutical facility requires the owner, engineer of record, and constructor to be knowledgeable with regard to the industry codes and standards that apply to this effort. Up until 1997 there were no industry standards directed at the needs and requirements of the pharmaceutical industry. Prior to that time it was a patchwork effort at resourcing and adopting nonpharmaceutical-related codes and standards and then modifying them in order to meet the more stringent requirements of the Food and Drug Administration (FDA). In 1997 the American Society of Mechanical Engineers (ASME) published the first Bioprocessing Equipment (BPE) Standard. Through harmonization efforts this relatively new standard has brought together, scrutinized, and refined industry accepted methodologies together with FDA compliance requirements, and has established an American National Standard that provides a comprehensive set of standards that are integral to the pharmaceutical industry. This article describes various American National Standards, including those developed and published by the American Society for Testing and Materials (ASTM), and how they apply to the pharmaceutical industry. It goes on to discuss the harmonization effort that takes place between the various standards developers in an attempt to prevent conflicts and omissions between the many standards. Also included are examples of tables and figures taken from the ASME-BPE Standard. These examples provide the reader with insight to the relevant content of the ASME-BPE Standard. Designing and building a pharmaceutical facility requires the owner, engineer of record, and constructor to be knowledgeable with regard to the industry codes and standards that apply to this effort. Up until 1997 there were no industry standards directed at the needs and requirements of the pharmaceutical industry. Prior to that time it was a patchwork effort at resourcing and adopting nonpharmaceutical-related codes and

  17. Radiografia Torácica em Crise Asmática

    OpenAIRE

    Sanches, Marcos; Marques, Patricia; Oliveira, Elisabete; Lopes, Aldina Canteiro

    2013-01-01

    Criança de oito anos, asmática que iniciou de forma súbita opressão torácica, disfagia e cansaço, motivo pelo qual recorreu ao serviço de urgência. Ao exame físico apresentava tiragem intercostal, polipneia e edema supraclavicular à direita crepitante. A auscultação pulmonar revelava murmúrio vesicular diminuído bilateralmente, aumento do tempo expiratório com sibilos dispersos. A radiografia (Rx) de tórax demonstrou sinais de pneumomediastino (figura 1), pelo que iniciou repouso e tratamento...

  18. Materials and design bases issues in ASME Code Case N-47

    International Nuclear Information System (INIS)

    Huddleston, R.L.; Swindeman, R.W.

    1993-04-01

    A preliminary evaluation of the design bases (principally ASME Code Case N-47) was conducted for design and operation of reactors at elevated temperatures where the time-dependent effects of creep, creep-fatigue, and creep ratcheting are significant. Areas where Code rules or regulatory guides may be lacking or inadequate to ensure the operation over the expected life cycles for the next-generation advanced high-temperature reactor systems, with designs to be certified by the US Nuclear Regulatory Commission, have been identified as unresolved issues. Twenty-two unresolved issues were identified and brief scoping plans developed for resolving these issues

  19. Batse/Sax and Batse/RXTE-ASM Joint Spectral Studies of GRBs

    Science.gov (United States)

    Paciesas, William S.

    2002-01-01

    We proposed to make joint spectral analysis of gamma-ray bursts (GRBs) in the BATSE data base that are located within the fields of view of either the BeppoSAX wide field cameras (WFCs) or the RXTE all-sky monitor (ASM). The very broad-band coverage obtained in this way would facilitate various studies of GRB spectra that are difficult to perform with BATSE data alone. Unfortunately, the termination of the CGRO mission in June 2000 was not anticipated at the time of the proposal, and the sample of common events turned out to be smaller than we would have liked.

  20. Robust boundary detection of left ventricles on ultrasound images using ASM-level set method.

    Science.gov (United States)

    Zhang, Yaonan; Gao, Yuan; Li, Hong; Teng, Yueyang; Kang, Yan

    2015-01-01

    Level set method has been widely used in medical image analysis, but it has difficulties when being used in the segmentation of left ventricular (LV) boundaries on echocardiography images because the boundaries are not very distinguish, and the signal-to-noise ratio of echocardiography images is not very high. In this paper, we introduce the Active Shape Model (ASM) into the traditional level set method to enforce shape constraints. It improves the accuracy of boundary detection and makes the evolution more efficient. The experiments conducted on the real cardiac ultrasound image sequences show a positive and promising result.

  1. Summary of design of nuclear vessels and piping to ASME III (NB, NC, ND) and vessels to BS 5500

    International Nuclear Information System (INIS)

    Harrop, L.P.

    1992-01-01

    There is a hierarchy of design code requirements for pressurised components, starting with non-nuclear codes as the minimum and progressing through the ASME III nuclear Classes 3, 2, 1. In establishing and assessing the safety justifications of nuclear plants it is important to have an appreciation of the gradation of requirements in the ASME III design rules and how these go beyond non-nuclear component design rules. There are two broad aspects to the structural integrity of pressurised components, namely the achievement of integrity and the demonstration of integrity. The technical requirements of design codes are associated with achieving integrity while the documentary aspects are usually associated with demonstrating integrity. In practice documents also have a part in achieving integrity in the communication of information between different organisations and personnel involved in the design process. It is not possible to assign simple numerical measures to the relative integrity afforded by non-nuclear codes and the three Classes of ASME III. Instead it is necessary to compare the different requirements of the rules for the various technical and documentary aspects. This paper summarises the most important technical and documentary aspects of the three Classes of the ASME III Code for vessels and the non-nuclear code BS 5500. A similar summary is also provided for the three Classes of ASME III rules for piping. The intention is that the paper provides a basis for appreciating the relative integrity afforded by these various rules. (author)

  2. Podcast: The Electronic Crimes Division

    Science.gov (United States)

    Sept 26, 2016. Chris Lukas, the Special Agent in Charge of the Electronic Crimes Division within the OIG's Office of Investigations talks about computer forensics, cybercrime in the EPA and his division's role in criminal investigations.

  3. 2016 T Division Lightning Talks

    Energy Technology Data Exchange (ETDEWEB)

    Ramsey, Marilyn Leann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Adams, Luke Clyde [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Ferre, Gregoire Robing [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Grantcharov, Vesselin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Iaroshenko, Oleksandr [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Krishnapriyan, Aditi [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Kurtakoti, Prajvala Kishore [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Le Thien, Minh Quan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Lim, Jonathan Ng [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Low, Thaddeus Song En [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Lystrom, Levi Aaron [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Ma, Xiaoyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Nguyen, Hong T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Pogue, Sabine Silvia [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Orandle, Zoe Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Reisner, Andrew Ray [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Revard, Benjamin Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Roy, Julien [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Sandor, Csanad [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Slavkova, Kalina Polet [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Weichman, Kathleen Joy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Wu, Fei [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division; Yang, Yang [Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Division

    2016-11-29

    These are the slides for all of the 2016 T Division lightning talks. There are 350 pages worth of slides from different presentations, all of which cover different topics within the theoretical division at Los Alamos National Laboratory (LANL).

  4. 2017 T Division Lightning Talks

    Energy Technology Data Exchange (ETDEWEB)

    Ramsey, Marilyn Leann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Abeywardhana, Jayalath AMM [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Adams, Colin Mackenzie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Adams, Luke Clyde [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carter, Austin Lewis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ducru, Pablo Philippe [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Duignan, Thomas John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gifford, Brendan Joel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hills, Benjamin Hale [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hoffman, Kentaro Jack [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Khair, Adnan Ibne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kochanski, Kelly Anne Pribble [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ledwith, Patrick John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Leveillee, Joshua Anthony [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lewis, Sina Genevieve [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ma, Xiaoyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Merians, Hugh Drake [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Moore, Bryan Alexander [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Nijjar, Parmeet Kaur [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Oles, Vladyslav [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olszewski, Maciej W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Philipbar, Brad Montgomery [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Reisner, Andrew Ray [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Roberts, David Benjamin [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rufa, Dominic Antonio [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sifain, Andrew E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Smith, Justin Steven [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Smith, Lauren Taylor Wisbey [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Svolos, Lampros [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Thibault, Joshua Ryan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ushijima-Mwesigwa, Hayato Montezuma [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Weaver, Claire Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Witzen, Wyatt Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Zentgraf, Sabine Silvia [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Alred, John Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-06

    All members of the T Division Community, students, staff members, group leaders, division management, and other interested individuals are invited to come and support the following student(s) as they present their Lightning Talks.

  5. Division of Integrity and Materials

    International Nuclear Information System (INIS)

    Zdarek, J.

    1995-01-01

    The organization structure is described of the Division of Integrity and Materials, Institute of Nuclear Research plc, Rez, and the main fields of their activities given. Listed are the major research projects of the Division in 1994. (Z.S.)

  6. Broncoespasmo induzido pelo exercício em adolescentes asmáticos obesos e não-obesos

    OpenAIRE

    Lopes,Wendell Arthur; Rosário,Nelson; Leite,Neiva

    2010-01-01

    OBJETIVO: Avaliar e comparar a frequência e intensidade do broncoespasmo induzido pelo exercício (BIE) em adolescentes asmáticos obesos e não-obesos. MÉTODOS: Estudo transversal e descritivo realizado com 39 adolescentes de ambos os sexos, com idade entre dez e 16 anos, divididos em dois grupos conforme o histórico clínico de asma e/ou rinite alérgica e o índice de massa corporal: asmáticos obesos (n=18); asmáticos não-obesos (n=21). Utilizou-se o teste de broncoprovocação com exercício para ...

  7. Comparison of ASME Code NB-3200 and NB-3600 results for fatigue analysis of B31.1 branch nozzles

    International Nuclear Information System (INIS)

    Nitzel, M.E.; Ware, A.G.; Morton, D.K.

    1996-01-01

    Fatigue analyses wre conducted on two reactor coolant system branch nozzles in an operating PWR designed to the B31.1 Code, for which no explicit fatigue analysis was required by the licensing basis. These analyses were performed as part of resolving issues connected with NRC's Fatigue Action Plan to determine if the cumulative usage factor (CUF) for these nozzles, using the 1992 ASME Code and representative PWR transients, were comparable to nozzles designed and analyzed to the ASME Code. Both NB-3200 and NB-3600 ASME Code methods were used. NB-3200 analyses included the development of finite element models for each nozzle. Although detailed thermal transients were not available for the plant analyzed, representative transients from similar PWRs were applied in each method. CUFs calculated using NB-3200 methods were significantly less than using NB-3600. The paper points out differences in analysis methods and highlights difficulties and unknowns in performing more detailed analyses to reduce conservative assumptions

  8. When a Plant Resistance Inducer Leaves the Lab for the Field: Integrating ASM into Routine Apple Protection Practices.

    Science.gov (United States)

    Marolleau, Brice; Gaucher, Matthieu; Heintz, Christelle; Degrave, Alexandre; Warneys, Romain; Orain, Gilles; Lemarquand, Arnaud; Brisset, Marie-Noëlle

    2017-01-01

    Plant resistance inducers, also called elicitors, could be useful to reduce the use of pesticides. However, their performance in controlling diseases in the field remains unsatisfactory due to lack of specific knowledge of how they can integrate crop protection practices. In this work, we focused on apple crop and acibenzolar- S -methyl (ASM), a well-known SAR (systemic acquired resistance) inducer of numerous plant species. We provide a protocol for orchard-effective control of apple scab due to the ascomycete fungus Venturia inaequalis , by applying ASM in combination with a light integrated pest management program. Besides we pave the way for future optimization levers by demonstrating in controlled conditions (i) the high influence of apple genotypes, (ii) the ability of ASM to prime defenses in newly formed leaves, (iii) the positive effect of repeated elicitor applications, (iv) the additive effect of a thinning fruit agent.

  9. Division of Labor

    KAUST Repository

    Oke, Muse

    2014-09-12

    The first assignment of DNA polymerases at the eukaryotic replication fork was possible after the in vitro reconstitution of the simian virus 40 (SV40) replication system. In this system, DNA polymerase α (Pol α) provides both leading and lagging strands with RNA-DNA primers that are extended by DNA polymerase δ (Pol δ). Extrapolating the architecture of the replication fork from the SV40 model system to an actual eukaryotic cell has been challenged by the discovery of a third DNA polymerase in Saccharomyces cerevisiae, DNA polymerase ε (Pol ε). A division of labor has been proposed for the eukaryotic replication fork whereby Pol ε replicates the leading strand and Pol δ replicates the lagging strand. However, an alternative model of unequal division of labor in which Pol δ can still participate in leading-strand synthesis is plausible.

  10. Code cases for implementing risk-based inservice testing in the ASME OM code

    Energy Technology Data Exchange (ETDEWEB)

    Rowley, C.W.

    1996-12-01

    Historically inservice testing has been reasonably effective, but quite costly. Recent applications of plant PRAs to the scope of the IST program have demonstrated that of the 30 pumps and 500 valves in the typical plant IST program, less than half of the pumps and ten percent of the valves are risk significant. The way the ASME plans to tackle this overly-conservative scope for IST components is to use the PRA and plant expert panels to create a two tier IST component categorization scheme. The PRA provides the quantitative risk information and the plant expert panel blends the quantitative and deterministic information to place the IST component into one of two categories: More Safety Significant Component (MSSC) or Less Safety Significant Component (LSSC). With all the pumps and valves in the IST program placed in MSSC or LSSC categories, two different testing strategies will be applied. The testing strategies will be unique for the type of component, such as centrifugal pump, positive displacement pump, MOV, AOV, SOV, SRV, PORV, HOV, CV, and MV. A series of OM Code Cases are being developed to capture this process for a plant to use. One Code Case will be for Component Importance Ranking. The remaining Code Cases will develop the MSSC and LSSC testing strategy for type of component. These Code Cases are planned for publication in early 1997. Later, after some industry application of the Code Cases, the alternative Code Case requirements will gravitate to the ASME OM Code as appendices.

  11. Modelling the biological performance of a side-stream membrane bioreactor using ASM1.

    Science.gov (United States)

    Tian, Ke-Jun; Liu, Xin-Ai; Jiang, Tao; Kennedy, M D; Schippers, J C; Vanrolleghem, P A

    2004-01-01

    Membrane bioreactors (MBRs) are attracting global interest but the mathematical modeling of the biological performance of MBRs remains very limited. This study focuses on the modelling of a side-stream MBR system using Activated Sludge Model No. 1 (ASM1), and comparing the results with the modelling of traditional activated sludge processes. ASM1 parameters relevant for the long-term biological behaviour in MBR systems were calibrated (i.e. Y(H) = 0.72gCOD/gCOD, Y(A) = 0.25gCOD/gN, b(H) = 0.25 d(-1), b(A) = 0.080 d(-1) and f(P) = 0.06), and generally agreed with the parameters in traditional activated sludge processes, with the exception that a higher autotrophic biomass decay rate was observed in the MBR. A sensitivity analysis for steady state operation and DO dynamics suggested that the biological performance of the MBR system (the sludge concentration, effluent quality and the DO dynamics) are very sensitive to the parameters(i.e. Y(H), Y(A), b(H), b(A), micro(maxH) and micro(maxA)), and influent wastewater components(X(I), S(S), X(S), S(NH)).

  12. ASM1 dynamic calibration and long-term validation for an intermittently aerated WWTP.

    Science.gov (United States)

    Marquot, A; Stricker, A E; Racault, Y

    2006-01-01

    Activated sludge models, and ASM1 in particular, are well recognised and useful mathematical representations of the macroscopic processes involved in the biological degradation of the pollution carried by wastewater. Nevertheless, the use of these models through simulation software requires a careful methodology for their calibration (determination of the model parameters' values) and the validation step (verification with an independent data set). This paper presents the methodology and the results of dynamic calibration and validation tasks as a prior work to a modelling project for defining a reference guideline destined to French designers and operators. To reach these goals, a biological nutrient removal (BNR) wastewater treatment plant (WWTP) with intermittent aeration was selected and monitored for 2 years. Two sets of calibrated parameters are given and discussed. The results of the long-term validation task are presented through a 2-month simulation with lots of operation changes. Finally, it is concluded that, even if calibrating ASM1 with a high degree of confidence with a single set of parameters was not possible, the results of the calibration are sufficient to obtain satisfactory results over long-term dynamic simulation. However, simulating long periods reveals specific calibration issues such as the variation of the nitrification capacity due to external events.

  13. A strategy for implementation of experience based seismic equipment qualification in IEEE and ASME industry standards

    International Nuclear Information System (INIS)

    Adams, T.M.

    1996-01-01

    In the past 20 years, extensive data on the performance of mechanical and electric equipment during actual strong motion earthquakes and seismic qualification tests has been accumulated. Recognizing that an experience based approach provides a technically sound and cost effective method for the seismic qualification of some or certain equipment, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment established a Special Working Group to investigate the incorporation of experienced based methods into the industry consensus codes and standards currently used in the seismic qualification of Seismic Category Nuclear Power Plant equipment. This paper presents the strategy (course of action) which was developed by the Special Working Group for meeting this objective of incorporation of experience based seismic qualification standards used in the design and seismic qualification of seismic category nuclear power plant equipment. This strategy was recommended to both chartering organizations, the IEEE Nuclear Power Engineering Committee and the ASME Committee on Qualification of Mechanical Equipment for their consideration and implementation. The status of the review and implementation of the Special Working Group's recommended strategy by the sponsoring organization is also discussed

  14. Description of comprehensive pump test change to ASME OM code, subsection ISTB

    International Nuclear Information System (INIS)

    Hartley, R.S.

    1994-01-01

    The American Society of Mechanical Engineers (ASME) Operations and Maintenance (OM) Main Committee and Board on Nuclear Codes and Standards (BNCS) recently approved changes to ASME OM Code-1990, Subsection ISTB, Inservice Testing of Pumps in Light-Water Reactor Power Plants. The changes will be included in the 1994 addenda to ISTB. The changes, designated as the comprehensive pump test, incorporate a new, improved philosophy for testing safety-related pumps in nuclear power plants. An important philosophical difference between the open-quotes old codeclose quotes inservice testing (IST) requirements and these changes is that the changes concentrate on less frequent, more meaningful testing while minimizing damaging and uninformative low-flow testing. The comprehensive pump test change establishes a more involved biannual test for all pumps and significantly reduces the rigor of the quarterly test for standby pumps. The increased rigor and cost of the biannual comprehensive tests are offset by the reduced cost of testing and potential damage to the standby pumps, which comprise a large portion of the safety-related pumps at most plants. This paper provides background on the pump testing requirements, discusses potential industry benefits of the change, describes the development of the comprehensive pump test, and gives examples and reasons for many of the specific changes. This paper also describes additional changes to ISTB that will be included in the 1994 addenda that are associated with, but not part of, the comprehensive pump test

  15. 3. Theoretical Physics Division

    International Nuclear Information System (INIS)

    For the period September 1980 - Aug 1981, the studies in theoretical physics divisions have been compiled under the following headings: in nuclear physics, nuclear structure, nuclear reactions and intermediate energies; in particle physics, NN and NantiN interactions, dual topological unitarization, quark model and quantum chromodynamics, classical and quantum field theories, non linear integrable equations and topological preons and Grand unified theories. A list of publications, lectures and meetings is included [fr

  16. Reconsidering Division Cavalry Squadrons

    Science.gov (United States)

    2017-05-25

    February of 1970, with the US Army’s withdrawal from Vietnam underway, 1-4 CAV assumed rearguard duty—an economy -of-force mission traditionally assigned to...operations case study in Vietnam , and a reconnaissance operations case study in the Persian Gulf, this study proposes a series of organizational...troop; squadron; regiment; division; corps; reconnaissance; security; Persian Gulf War; Vietnam ; task force; brigade combat team; modularity; tank

  17. Mapping Urban Social Divisions

    Directory of Open Access Journals (Sweden)

    Susan Ball

    2010-05-01

    Full Text Available Against the background of increased levels of interest in space and images beyond the field of geography, this article (re- introduces earlier work on the semiotics of maps undertaken by geographers in the 1960s. The data limitations, purpose and cultural context in which a user interprets a map's codes and conventions are highlighted in this work, which remains relevant to the interpretation of maps—new and old—forty years later. By means of drawing on geography's contribution to the semiotics of maps, the article goes on to examine the concept of urban social divisions as represented in map images. Using a small number of map images, including two of the most widely known maps of urban social division in Europe and North America, the roles of context, data and purpose in the production and interpretation of maps are discussed. By presenting the examples chronologically the article shows that although advances in data collection and manipulation have allowed researchers to combine different social variables in maps of social division, and to interact with map images, work by geographers on the semiotics of maps is no less relevant today than when it was first proposed forty years ago. URN: urn:nbn:de:0114-fqs1002372

  18. Application of adjusted subpixel method (ASM) in HRCT measurements of the bronchi in bronchial asthma patients and healthy individuals.

    Science.gov (United States)

    Mincewicz, Grzegorz; Rumiński, Jacek; Krzykowski, Grzegorz

    2012-02-01

    Recently, we described a model system which included corrections of high-resolution computed tomography (HRCT) bronchial measurements based on the adjusted subpixel method (ASM). To verify the clinical application of ASM by comparing bronchial measurements obtained by means of the traditional eye-driven method, subpixel method alone and ASM in a group comprised of bronchial asthma patients and healthy individuals. The study included 30 bronchial asthma patients and the control group comprised of 20 volunteers with no symptoms of asthma. The lowest internal and external diameters of the bronchial cross-sections (ID and ED) and their derivative parameters were determined in HRCT scans using: (1) traditional eye-driven method, (2) subpixel technique, and (3) ASM. In the case of the eye-driven method, lower ID values along with lower bronchial lumen area and its percentage ratio to total bronchial area were basic parameters that differed between asthma patients and healthy controls. In the case of the subpixel method and ASM, both groups were not significantly different in terms of ID. Significant differences were observed in values of ED and total bronchial area with both parameters being significantly higher in asthma patients. Compared to ASM, the eye-driven method overstated the values of ID and ED by about 30% and 10% respectively, while understating bronchial wall thickness by about 18%. Results obtained in this study suggest that the traditional eye-driven method of HRCT-based measurement of bronchial tree components probably overstates the degree of bronchial patency in asthma patients. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  19. Low appendicular skeletal muscle mass (ASM) with limited mobility and poor health outcomes in middle-aged African Americans.

    Science.gov (United States)

    Malmstrom, Theodore K; Miller, Douglas K; Herning, Margaret M; Morley, John E

    2013-09-01

    Recent efforts to provide a consensus definition propose that sarcopenia be considered a clinical syndrome associated with the loss of both skeletal muscle mass and muscle function that occurs with aging. Validation of sarcopenia definitions that include both low muscle mass and poor muscle function is needed. In the population-based African American Health (AAH) study (N = 998 at baseline/wave 1), muscle mass and mobility were evaluated in a clinical testing center in a subsample of N = 319 persons (ages 52-68) at wave 4 (2004). Muscle mass was measured using dual energy x-ray absorptiometry and mobility by a 6-min walk test and 4-m gait walk test. Height corrected appendicular skeletal mass (ASM; 9.0 ± 1.5 in n = 124 males, 8.3 ± 2.2 in n = 195 females) was computed as total lean muscle mass in arms and legs (kilograms) divided by the square of height (meters). Cross-sectional and longitudinal (6-year) associations of low ASM (bottom 25 % AAH sample; ASM with limited mobility (4-m gait walk ≤1 m/s or 6-min walk ASM with limited mobility was associated with IADL difficulties (p = .008) and frailty (p = .040) but not with ADL difficulties or falls in cross-sectional analyses; and with ADL difficulties (p = .022), IADL difficulties (p = .006), frailty (p = .039), and mortality (p = .003) but not with falls in longitudinal analyses adjusted for age and gender. Low ASM alone was marginally associated with mortality (p = .085) but not with other outcomes in cross-sectional or longitudinal analyses. Low ASM with limited mobility is associated with poor health outcomes among late middle-aged African Americans.

  20. 3D automatic anatomy segmentation based on iterative graph-cut-ASM

    International Nuclear Information System (INIS)

    Chen, Xinjian; Bagci, Ulas

    2011-01-01

    Purpose: This paper studies the feasibility of developing an automatic anatomy segmentation (AAS) system in clinical radiology and demonstrates its operation on clinical 3D images. Methods: The AAS system, the authors are developing consists of two main parts: object recognition and object delineation. As for recognition, a hierarchical 3D scale-based multiobject method is used for the multiobject recognition task, which incorporates intensity weighted ball-scale (b-scale) information into the active shape model (ASM). For object delineation, an iterative graph-cut-ASM (IGCASM) algorithm is proposed, which effectively combines the rich statistical shape information embodied in ASM with the globally optimal delineation capability of the GC method. The presented IGCASM algorithm is a 3D generalization of the 2D GC-ASM method that they proposed previously in Chen et al.[Proc. SPIE, 7259, 72590C1-72590C-8 (2009)]. The proposed methods are tested on two datasets comprised of images obtained from 20 patients (10 male and 10 female) of clinical abdominal CT scans, and 11 foot magnetic resonance imaging (MRI) scans. The test is for four organs (liver, left and right kidneys, and spleen) segmentation, five foot bones (calcaneus, tibia, cuboid, talus, and navicular). The recognition and delineation accuracies were evaluated separately. The recognition accuracy was evaluated in terms of translation, rotation, and scale (size) error. The delineation accuracy was evaluated in terms of true and false positive volume fractions (TPVF, FPVF). The efficiency of the delineation method was also evaluated on an Intel Pentium IV PC with a 3.4 GHZ CPU machine. Results: The recognition accuracies in terms of translation, rotation, and scale error over all organs are about 8 mm, 10 deg. and 0.03, and over all foot bones are about 3.5709 mm, 0.35 deg. and 0.025, respectively. The accuracy of delineation over all organs for all subjects as expressed in TPVF and FPVF is 93.01% and 0.22%, and

  1. 3D automatic anatomy segmentation based on iterative graph-cut-ASM.

    Science.gov (United States)

    Chen, Xinjian; Bagci, Ulas

    2011-08-01

    This paper studies the feasibility of developing an automatic anatomy segmentation (AAS) system in clinical radiology and demonstrates its operation on clinical 3D images. The AAS system, the authors are developing consists of two main parts: object recognition and object delineation. As for recognition, a hierarchical 3D scale-based multiobject method is used for the multiobject recognition task, which incorporates intensity weighted ball-scale (b-scale) information into the active shape model (ASM). For object delineation, an iterative graph-cut-ASM (IGCASM) algorithm is proposed, which effectively combines the rich statistical shape information embodied in ASM with the globally optimal delineation capability of the GC method. The presented IGCASM algorithm is a 3D generalization of the 2D GC-ASM method that they proposed previously in Chen et al. [Proc. SPIE, 7259, 72590C1-72590C-8 (2009)]. The proposed methods are tested on two datasets comprised of images obtained from 20 patients (10 male and 10 female) of clinical abdominal CT scans, and 11 foot magnetic resonance imaging (MRI) scans. The test is for four organs (liver, left and right kidneys, and spleen) segmentation, five foot bones (calcaneus, tibia, cuboid, talus, and navicular). The recognition and delineation accuracies were evaluated separately. The recognition accuracy was evaluated in terms of translation, rotation, and scale (size) error. The delineation accuracy was evaluated in terms of true and false positive volume fractions (TPVF, FPVF). The efficiency of the delineation method was also evaluated on an Intel Pentium IV PC with a 3.4 GHZ CPU machine. The recognition accuracies in terms of translation, rotation, and scale error over all organs are about 8 mm, 10 degrees and 0.03, and over all foot bones are about 3.5709 mm, 0.35 degrees and 0.025, respectively. The accuracy of delineation over all organs for all subjects as expressed in TPVF and FPVF is 93.01% and 0.22%, and all foot bones for

  2. Division Quilts: A Measurement Model

    Science.gov (United States)

    Pratt, Sarah S.; Lupton, Tina M.; Richardson, Kerri

    2015-01-01

    As teachers seek activities to assist students in understanding division as more than just the algorithm, they find many examples of division as fair sharing. However, teachers have few activities to engage students in a quotative (measurement) model of division. Efraim Fischbein and his colleagues (1985) defined two types of whole-number…

  3. Chemical Technology Division annual technical report, 2001

    International Nuclear Information System (INIS)

    Lewis, D.; Gay, E. C.; Miller, J. C.; Boparai, A. S.

    2002-01-01

    The Chemical Technology Division (CMT) is one of eight engineering research divisions within Argonne National Laboratory, one of the U.S. government's oldest and largest research laboratories. The University of Chicago oversees the laboratory on behalf of the U.S. Department of Energy (DOE). Argonne's mission is to conduct basic scientific research, to operate national scientific facilities, to enhance the nation's energy resources, and to develop better ways to manage environmental problems. Argonne has the further responsibility of strengthening the nation's technology base by developing innovative technology and transferring it to industry. CMT is a diverse early-stage engineering organization, specializing in the treatment of spent nuclear fuel, development of advanced electrochemical power sources, and management of both high- and low-level nuclear wastes. Although this work is often indistinguishable from basic research, our efforts are directed toward the practical devices and processes that are covered by Argonne's mission. Additionally, the Division operates the Analytical Chemistry Laboratory and Environment, Safety, and Health Analytical Chemistry services, which provide a broad range of analytical services to Argonne and other organizations. The Division is multidisciplinary. Its people have formal training as ceramists; physicists; material scientists; electrical, mechanical, chemical, and nuclear engineers; and chemists. They have experience working in academia; urban planning; and the petroleum, aluminum, and automotive industries. Their skills include catalysis, ceramics, electrochemistry, metallurgy, nuclear magnetic resonance spectroscopy, and petroleum refining, as well as the development of nuclear waste forms, batteries, and high-temperature superconductors

  4. 46 CFR 56.60-1 - Acceptable materials and specifications (replaces 123 and Table 126.1 in ASME B31.1).

    Science.gov (United States)

    2010-10-01

    ... iron Conform to applicable American National Standards or refer to UCI-23 or UCD-23, Sec. VIII of the... acceptable iron castings are in UCI-23 and UCD-23 of section VIII of the ASME Boiler and Pressure Vessel Code... pressure temperature limitations refer to UCI-3 of section VIII of the ASME Boiler and Pressure Vessel Code...

  5. Incorporation of the concept of microbial product formation into ASM3 and the modeling of a membrane bioreactor for wastewater treatment

    Directory of Open Access Journals (Sweden)

    K. P. Oliveira-Esquerre

    2006-12-01

    Full Text Available This paper proposes a modification of ASM3 in a way that takes into account the process of production and consumption of microbial products (MPs in a submerged membrane bioreactor fed with the effluent of a particular precoagulation sedimentation unit. A comparative representation of the modeling results obtained with ASM3 and ASM1 is performed and it highlights the importance of considering the process of storage of organic substrate, including MPs, as a prior step to bacterial growth. In addition to the suspended solids and microorganisms, various soluble organic substances, which might be either undecomposed organic substances contained in the raw water or MPs, are assumed to be selectively retained within the bioreactor. The results show that the carbonaceous materials are more accurately estimated by ASM3, while ASM1 performs slightly better than ASM3 in the estimation of nitrate. The estimated MP concentration in the mixed liquor and permeate agrees with the experimental evidence, and as expected, MPs play a role in supplying organic substrate to heterotrophs in both ASM1 and ASM3.

  6. Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca(2+) regulation in airway smooth muscle (ASM).

    Science.gov (United States)

    Delmotte, Philippe; Sieck, Gary C

    2015-02-01

    Airway inflammation is a key aspect of diseases such as asthma. Several inflammatory cytokines (e.g., TNFα and IL-13) increase cytosolic Ca(2+) ([Ca(2+)]cyt) responses to agonist stimulation and Ca(2+) sensitivity of force generation, thereby enhancing airway smooth muscle (ASM) contractility (hyper-reactive state). Inflammation also induces ASM proliferation and remodeling (synthetic state). In normal ASM, the transient elevation of [Ca(2+)]cyt induced by agonists leads to a transient increase in mitochondrial Ca(2+) ([Ca(2+)]mito) that may be important in matching ATP production with ATP consumption. In human ASM (hASM) exposed to TNFα and IL-13, the transient increase in [Ca(2+)]mito is blunted despite enhanced [Ca(2+)]cyt responses. We also found that TNFα and IL-13 induce reactive oxidant species (ROS) formation and endoplasmic/sarcoplasmic reticulum (ER/SR) stress (unfolded protein response) in hASM. ER/SR stress in hASM is associated with disruption of mitochondrial coupling with the ER/SR membrane, which relates to reduced mitofusin 2 (Mfn2) expression. Thus, in hASM it appears that TNFα and IL-13 result in ROS formation leading to ER/SR stress, reduced Mfn2 expression, disruption of mitochondrion-ER/SR coupling, decreased mitochondrial Ca(2+) buffering, mitochondrial fragmentation, and increased cell proliferation.

  7. Engineering Physics and Mathematics Division progress report for period ending December 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Sincovec, R.F.

    1995-07-01

    This report provides a record of the research activities of the Engineering Physics and Mathematics Division for the period January 1, 1993, through December 31, 1994. This report is the final archival record of the EPM Division. On October 1, 1994, ORELA was transferred to Physics Division and on January 1, 1995, the Engineering Physics and Mathematics Division and the Computer Applications Division reorganized to form the Computer Science and Mathematics Division and the Computational Physics and Engineering Division. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL`s research in the mathematical sciences prior to 1984 when those activities moved into the Engineering Physics and Mathematics Division.

  8. Engineering Physics and Mathematics Division progress report for period ending December 31, 1994

    International Nuclear Information System (INIS)

    Sincovec, R.F.

    1995-07-01

    This report provides a record of the research activities of the Engineering Physics and Mathematics Division for the period January 1, 1993, through December 31, 1994. This report is the final archival record of the EPM Division. On October 1, 1994, ORELA was transferred to Physics Division and on January 1, 1995, the Engineering Physics and Mathematics Division and the Computer Applications Division reorganized to form the Computer Science and Mathematics Division and the Computational Physics and Engineering Division. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research in the mathematical sciences prior to 1984 when those activities moved into the Engineering Physics and Mathematics Division

  9. Development of a software for the ASME code qualification of class-I nuclear piping systems

    International Nuclear Information System (INIS)

    Mishra, Rajesh; Umashankar, C.; Soni, R.S.; Kushwaha, H.S.; Venkat Raj, V.

    1999-11-01

    In nuclear industry, the designer often comes across the requirements of Class-1 piping systems which need to be qualified for various normal and abnormal loading conditions. In order to have quick design changes and the design reviews at various stages of design, it is quite helpful if a dedicated software is available for the qualification of Class-1 piping systems. BARC has already purchased a piping analysis software CAESAR-II and has used it for the life extension of heavy water plant, Kota. CAESAR-II facilitates the qualification of Class-2 and Class-3 piping systems among others. However, the present version of CAESAR-II does not have the capability to perform stress checks for the ASME Class-1 nuclear piping systems. With this requirement in mind and the prohibitive costs of commercially available software for the Class-1 piping analyses, it was decided to develop a separate software for this class of piping in such a way that the input and output details of the piping from the CAESAR-II software can be made use of. This report principally contains the details regarding development of a software for codal qualification of Class-1 nuclear piping as per ASME code section-III, NB-3600. The entire work was carried out in three phases. The first phase consisted of development of the routines for reading the output files obtained from the CAESAR-II software, and converting them into required format for further processing. In this phase, the nodewise informations available from the CAESAR-II output file were converted into element-wise informations. The second phase was to develop a general subroutine for reading the various input parameters such as diameter, wall thickness, corrosion allowance, bend radius and also to recognize the bend elements based on the bend radius, directly from the input file of CAESAR-II software. The third phase was regarding the incorporation of the required steps for performing the ASME codal checks as per NB-3600 for Class-1 piping

  10. Aspects of Fair Division,

    Science.gov (United States)

    1980-04-01

    Kuhn, H. W. "On Games of Fair Division," in Essays in Mathematical Economics in honor of Oskar Morgenstern , Princeton University Press, 1967, [9] Neyman...valuation of the ith participant. If the game (N,v) is symmetric in the Von Nuemann- Morgenstern sense (14], Ch.X), it can be shown that D = = " = tn...Mathematicae, Vol. 16, 1930, pp. 140-150. [14] Von Neumann, J., and 0. Morgenstern , Theory of Games and Economic Behavior, Princeton University Press, Princeton, 1944.

  11. Impact of the A18.1 ASME Standard on Platform Lifts and Stairway Chairlifts on Accessibility and Usability

    Science.gov (United States)

    Balmer, David C.

    2010-01-01

    This article summarizes the effect of the ASME A18.1 Standard concerning accessibility and usability of Platform Lifts and their remaining technological challenges. While elevators are currently the most effective means of vertical transportation related to speed, capacity, rise and usability, their major drawbacks for accessibility are cost and…

  12. Modeling Nitrous Oxide Production during Biological Nitrogen Removal via Nitrification and Denitrification: Extensions to the General ASM Models

    DEFF Research Database (Denmark)

    Ni, Bing-Jie; Ruscalleda, Maël; Pellicer i Nàcher, Carles

    2011-01-01

    Nitrous oxide (N2O) can be formed during biological nitrogen (N) removal processes. In this work, a mathematical model is developed that describes N2O production and consumption during activated sludge nitrification and denitrification. The well-known ASM process models are extended to capture N2O...

  13. Simulation of municipal-industrial full scale WWTP in an arid climate by application of ASM3

    Directory of Open Access Journals (Sweden)

    Abdelsalam Elawwad

    2017-03-01

    Full Text Available In developing countries, and due to the high cost of treatment of industrial wastewater, municipal wastewater treatment facilities usually receive a mixture of municipal wastewater and partially treated industrial wastewater. As a result, an increased potential for shock loads with high pollutant concentrations is expected. The use of mathematical modelling of wastewater treatment is highly efficient in such cases. A dynamic model based on activated sludge model no. 3 (ASM3 describing the performance of the activated sludge process at a full scale wastewater treatment plant (WWTP receiving mixed domestic–industrial wastewater located in an arid area is presented. ASM3 was extended by adding the Arrhenius equation to respond to changes in temperature. BioWin software V.4 was used as the model platform. The model was calibrated under steady-state conditions, adjusting only three kinetic and stoichiometric parameters: maximum heterotrophic growth rate (μH = 8 d−1, heterotrophic aerobic decay rate (bH, O2 = 0.18 d−1, and aerobic heterotrophic yield (YH,O2 = 0.4 (gCOD/gCOD. ASM3 was successful in predicting the WWTP performance, as the model was validated with 10 months of routine daily measurements. ASM3 extended with the Arrhenius equation could be helpful in the design and operation of WWTPs with mixed municipal–industrial influent in arid areas.

  14. Nuclear Power Division

    International Nuclear Information System (INIS)

    Anon.

    1981-01-01

    The 1981-85 research program planned by the Nuclear Power Division of EPRI places major emphasis on the assurance of safety and realiability of light water reactors (LWRs). Of high priority is a better knowledge of LWR-system behavior undeer abnormal conditions and the behavior of structural materials used for pressure vessels, piping, and large nuclear-plant components. Strong emphasis is also placed on achieving the most-effective performance and utilization of nuclear fuels and improving the corrosion resistance of pressurized-water-reactor steam generators. Efforts are underway to reduce radiation exposure and outage duration and to investigate the human factors involved in plant operation and maintenance. Substantial emphasis is placed on short-range goals designed to achieve useful results in the next two to seven years. The Division's mid- and long-range goal is to improve the use of fissionable and fertile materials and aid in the realization of other reactor systems. A series of general goals, categorized into three time frames and planned expenditures shows the trend of work to be undertaken. 53 figures

  15. Change of nonlinear acoustics in ASME grade 122 steel welded joint during creep

    Science.gov (United States)

    Ohtani, Toshihiro; Honma, Takumi; Ishii, Yutaka; Tabuchi, Masaaki; Hongo, Hiromichi; Hirao, Masahiko

    2016-02-01

    In this paper, we described the changes of two nonlinear acoustic characterizations; resonant frequency shift and three-wave interaction, with electromagnetic acoustic resonance (EMAR) throughout the creep life in the welded joints of ASME Grade 122, one of high Cr ferritic heat resisting steels. EMAR was a combination of the resonant acoustic technique with a non-contact electromagnetic acoustic transducer (EMAT). These nonlinear acoustic parameters decreased from the start to 50% of creep life. After slightly increased, they rapidly increased from 80% of creep life to rupture. We interpreted these phenomena in terms of dislocation recovery, recrystallization, and restructuring related to the initiation and growth of creep void, with support from the SEM and TEM observation.

  16. ASME B89.4.19 Performance Evaluation Tests and Geometric Misalignments in Laser Trackers.

    Science.gov (United States)

    Muralikrishnan, B; Sawyer, D; Blackburn, C; Phillips, S; Borchardt, B; Estler, W T

    2009-01-01

    Small and unintended offsets, tilts, and eccentricity of the mechanical and optical components in laser trackers introduce systematic errors in the measured spherical coordinates (angles and range readings) and possibly in the calculated lengths of reference artifacts. It is desirable that the tests described in the ASME B89.4.19 Standard [1] be sensitive to these geometric misalignments so that any resulting systematic errors are identified during performance evaluation. In this paper, we present some analysis, using error models and numerical simulation, of the sensitivity of the length measurement system tests and two-face system tests in the B89.4.19 Standard to misalignments in laser trackers. We highlight key attributes of the testing strategy adopted in the Standard and propose new length measurement system tests that demonstrate improved sensitivity to some misalignments. Experimental results with a tracker that is not properly error corrected for the effects of the misalignments validate claims regarding the proposed new length tests.

  17. Technical Review on Fitness-for-Service for Buried Pipe by ASME Code Case N-806

    International Nuclear Information System (INIS)

    Park, Sang Kyu; Lee, Yo Seop; So, Il Su; Lim, Bu Taek

    2012-01-01

    Fitness-for-Service is a useful technology to determine replacement timing, next inspection timing or in-service when nuclear power plant's buried pipes are damaged. If is possible for buried pipes to be aged by material loss, cracks and occlusion as operating time goes by. Therefore Fitness-for-Service technology for buried pipe is useful for plant industry to perform replacement and repair. Fitness-for-Service for buried pipe is studied in terms of existing code and standard for Fitness-for-Service and a current developing code case. Fitness-for-Service for buried pipe was performed according to Code Case N-806 developed by ASME (American Society of Mechanical Engineers)

  18. Linearization in ASM1 model for the solution of pollutants transport equations

    Directory of Open Access Journals (Sweden)

    Neyva Maria Lopes Romeiro

    2008-08-01

    Full Text Available It is proposed to reduce the complexity existing in non-linear BIOMOC and ASM1 models using Taylor’s frst-order series expansion in the terms whose reactive processes are non-linear. One of the advantages of linear models is the conservation of non-linear model variables. However, the main characteristic of this methodology refers to the computational time obtained in the numeral simulations, which is much shorter than that concerning the non-linear model results. Numerical results are presented, showing the effciency, precision and solidity of the proposed technique in well-known cases in the literature, using the semi-discrete method of finite elements.

  19. ASME power test code ptc 4.1 for steam generators; Codigo de pruebas de potencia ASME ptc 4.1 para generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Plauchu Alcantara, Jorge Alberto [Plauchu Consultores, Morelia, Michoacan (Mexico)

    2001-07-01

    This presentation is oriented towards those who in this subject have experience in the design and equipment specification, plant projects, factory and field testing, operation or result analyses. An important fraction of the national energy supply, approximately 13%, is applied to the steam generation in the different aspects of the industrial activity, in the electrical industry of public service and in the commercial and services sector. The development of the national programs of energy efficiency verifies this when dedicating to this use of the energy important projects, some of them with support of the USAID. The measurement of the energy utilization or the efficiency of steam generators (or boilers) is made applying some procedure agreed by the parts and the one of greater acceptance and best known in Mexico and internationally is the ASME Power Test Code PTC 4.1 for Steam Generators. The purpose and formality in the determination of efficiency and of steam generation capacity behavior, thermal basic regime or fulfillment of guarantees, radically changes the exigencies of strict attachment to the PTC 4.1 This definition will determine the importance of the test method selected, the deviations and convened exceptions, the influence of the precision and the measurement errors, the consideration of auxiliary equipment, etc. An interpretation or incorrect application of the Test Code has lead and will lead to results and nonreliable decisions. [Spanish] Esta exposicion se orienta a quienes en este tema cuenta con experiencia en diseno y especificacion de equipo, proyecto de planta, pruebas en fabrica y campo, operacion o analisis de resultados. Una fraccion importante de la oferta nacional de energia, 13% aproximadamente, se aplica a la generacion de vapor en diferentes giros de actividad industrial, en la industria electrica, de servicio publico y en el sector de servicios y comercial. El desarrollo de los programas nacionales de eficiencia energetica comprueba

  20. Using ASM Podcasts to Excite Undergraduate Students about Current Microbiological Research

    Directory of Open Access Journals (Sweden)

    Stacey E. Lettini

    2014-08-01

    Full Text Available Innovative technology is often used as a mechanism to engage students in and out of the classroom and can be used to increase critical thinking skills. Podcasts are an excellent way to introduce students to current topics and research in microbiology. The American Society for Microbiology (ASM produces three podcasts that are microbiologically focused: This Week in Microbiology (TWiM, This Week in Parasitology (TWiP, and This Week in Virology (TWiV. These podcasts are usually presented in a manner similar to a journal club, as the presenters regularly invite guests to discuss current research papers. Since students often find reading scientific literature difficult and get bogged down in the details rather than seeing the over-arching purpose of a paper, these podcasts have been used in a General Microbiology course to introduce recent research articles. The students were first assigned an original research article to read and review, and they were asked to generate questions pertaining to things they did not understand. Next, students listened to the corresponding podcast that discussed the article and used it to answer their questions. This was followed by a classroom discussion of the article and the podcast. The ASM podcast helped to demystify original research by providing details of the experimental design and presentation of the results in a language that is more casual and relatable. Students demonstrated greater critical thinking and comprehension of microbiology literature after listening to the podcast. This activity can be used in a variety of courses in the biology curriculum.

  1. User-inspired design methodology using Affordance Structure Matrix (ASM for construction projects

    Directory of Open Access Journals (Sweden)

    Maheswari J. Uma

    2017-01-01

    Full Text Available Traditionally, design phase of construction projects is often performed with incomplete and inaccurate user preferences. This is due to inefficiencies in the methodologies used for capturing the user requirements that can subsequently lead to inconsistencies and result in non-optimised end-result. Iterations and subsequent reworks due to such design inefficiencies is one of the major reasons for unsuccessful project delivery as they impact project performance measures such as time and cost among others. The existing design theories and practice are primarily based on functional requirements. Function-based design deals with design of artifact alone, which may yield favourable or unfavourable consequences with the design artifact. However, incorporating other interactions such as interactions between user & designer is necessary for optimised end-result. Hence, the objective of this research work is to devise a systematic design methodology considering all the three interactions among users, designers and artefacts for improved design efficiency. In this study, it has been attempted to apply the theory of affordances in a case project that involves the design of an offshore facility. A step-by-step methodology for developing Affordance Structure Matrix (ASM, which integrates House of Quality (HOQ and Design Structure Matrix (DSM, is proposed that can effectively capture the user requirements. HOQ is a popular quality management tool for capturing client requirements and DSM is a matrix-based tool that can capture the interdependency among the design entities. The proposed methodology utilises the strengths of both the tools, as DSM compliments HOQ in the process. In this methodology, different affordances such as AUA (Artifact-User-Affordance, AAA (Artifact-Artifact-Affordance and DDA (Designer-Designer-Affordance are captured systematically. Affordance is considered to be user-driven in this context that is in contrast to prevailing design

  2. Live birth potential of good morphology and vitrified blastocysts presenting abnormal cell divisions.

    Science.gov (United States)

    Azzarello, Antonino; Hoest, Thomas; Hay-Schmidt, Anders; Mikkelsen, Anne Lis

    2017-06-01

    This study included 238 good morphology blastocysts, which were transferred after vitrification-warming to 152 women by single blastocyst transfer in Holbæk Fertility Clinic, Denmark. Time-lapse recordings of transferred good morphology blastocysts were reassessed to recognize every abnormal cell division (ACD) from the 1st to the 4th cell cycle. ACDs were distinguished as failed cell divisions and multi-cell divisions. ACDs were recognized in 37.0% (no. 88/238) of good morphology blastocysts that were vitrified-warmed and transferred in our clinic. Good morphology blastocysts with ACDs showed a lower live birth rate (17.0%) than blastocyst with solely regular cell divisions (29.3%). ACDs could occur at more than one cell division in the same good morphology blastocyst. Reported as independent events, we observed ACDs occurring more frequently at the later cell cycles (1st: 1.3%; 2nd: 8.0%; 3rd: 18.5%; 4th: 18.1%). More blastocysts presented failed cell divisions (no. 95) than multi-cell divisions (no. 14). Live births were achieved from blastocysts showing multi-cell divisions at any cell cycle and failed cell divisions from the 2nd cell cycle. Analyses of the subgroup of first blastocyst transferred to each patient showed similar to results. In conclusion, good morphology blastocysts presenting ACDs can result in live birth although lower compared to blastocysts with solely regular cell division. Pre-implantation embryos in vitro may undergo self-selection or correcting processes. This supports the transfer of blastocysts instead of cleavage stage embryos, giving first priority to blastocyst showing solely regular cell divisions, and giving second priority to blastocysts presenting ACDs at any cell cycle. Copyright © 2017 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  3. Comparative evaluation of structural integrity for ITER blanket shield block based on SDC-IC and ASME code

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Hee-Jin [ITER Korea, National Fusion Research Institute, 169-148 Gwahak-Ro, Yuseong-Gu, Daejeon (Korea, Republic of); Ha, Min-Su, E-mail: msha12@nfri.re.kr [ITER Korea, National Fusion Research Institute, 169-148 Gwahak-Ro, Yuseong-Gu, Daejeon (Korea, Republic of); Kim, Sa-Woong; Jung, Hun-Chea [ITER Korea, National Fusion Research Institute, 169-148 Gwahak-Ro, Yuseong-Gu, Daejeon (Korea, Republic of); Kim, Duck-Hoi [ITER Organization, Route de Vinon sur Verdon - CS 90046, 13067 Sant Paul Lez Durance (France)

    2016-11-01

    Highlights: • The procedure of structural integrity and fatigue assessment was described. • Case studies were performed according to both SDC-IC and ASME Sec. • III codes The conservatism of the ASME code was demonstrated. • The study only covers the specifically comparable case about fatigue usage factor. - Abstract: The ITER blanket Shield Block is a bulk structure to absorb radiation and to provide thermal shielding to vacuum vessel and external vessel components, therefore the most significant load for Shield Block is the thermal load. In the previous study, the thermo-mechanical analysis has been performed under the inductive operation as representative loading condition. And the fatigue evaluations were conducted to assure structural integrity for Shield Block according to Structural Design Criteria for In-vessel Components (SDC-IC) which provided by ITER Organization (IO) based on the code of RCC-MR. Generally, ASME code (especially, B&PV Sec. III) is widely applied for design of nuclear components, and is usually well known as more conservative than other specific codes. For the view point of the fatigue assessment, ASME code is very conservative compared with SDC-IC in terms of the reflected K{sub e} factor, design fatigue curve and other factors. Therefore, an accurate fatigue assessment comparison is needed to measure of conservatism. The purpose of this study is to provide the fatigue usage comparison resulting from the specified operating conditions shall be evaluated for Shield Block based on both SDC-IC and ASME code, and to discuss the conservatism of the results.

  4. Verification of Allowable Stresses In ASME Section III Subsection NH For Grade 91 Steel & Alloy 800H

    Energy Technology Data Exchange (ETDEWEB)

    R. W. Swindeman; M. J. Swindeman; B. W. Roberts; B. E. Thurgood; D. L. Marriott

    2007-11-30

    The database for the creep-rupture of 9Cr-1Mo-V (Grade 91) steel was collected and reviewed to determine if it met the needs for recommending time-dependent strength values, S{sub t}, for coverage in ASME Section III Subsection NH (ASME III-NH) to 650 C (1200 F) and 600,000 hours. The accumulated database included over 300 tests for 1% total strain, nearly 400 tests for tertiary creep, and nearly 1700 tests to rupture. Procedures for analyzing creep and rupture data for ASME III-NH were reviewed and compared to the procedures used to develop the current allowable stress values for Gr 91 for ASME II-D. The criteria in ASME III-NH for estimating S{sub t} included the average strength for 1% total strain for times to 600,000 hours, 80% of the minimum strength for tertiary creep for times to 600,000 hours, and 67% of the minimum rupture strength values for times to 600,000 hours. Time-temperature-stress parametric formulations were selected to correlate the data and make predictions of the long-time strength. It was found that the stress corresponding to 1% total strain and the initiation of tertiary creep were not the controlling criteria over the temperature-time range of concern. It was found that small adjustments to the current values in III-NH could be introduced but that the existing values were conservative and could be retained. The existing database was found to be adequate to extend the coverage to 600,000 hours for temperatures below 650 C (1200 F).

  5. Corticosteroid-Induced MKP-1 Represses Pro-Inflammatory Cytokine Secretion by Enhancing Activity of Tristetraprolin (TTP) in ASM Cells.

    Science.gov (United States)

    Prabhala, Pavan; Bunge, Kristin; Ge, Qi; Ammit, Alaina J

    2016-10-01

    Exaggerated cytokine secretion drives pathogenesis of a number of chronic inflammatory diseases, including asthma. Anti-inflammatory pharmacotherapies, including corticosteroids, are front-line therapies and although they have proven clinical utility, the molecular mechanisms responsible for their actions are not fully understood. The corticosteroid-inducible gene, mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1, DUSP1) has emerged as a key molecule responsible for the repressive effects of steroids. MKP-1 is known to deactivate p38 MAPK phosphorylation and can control the expression and activity of the mRNA destabilizing protein-tristetraprolin (TTP). But whether corticosteroid-induced MKP-1 acts via p38 MAPK-mediated modulation of TTP function in a pivotal airway cell type, airway smooth muscle (ASM), was unknown. While pretreatment of ASM cells with the corticosteroid dexamethasone (preventative protocol) is known to reduce ASM synthetic function in vitro, the impact of adding dexamethasone after stimulation (therapeutic protocol) had not been explored. Whether dexamethasone modulates TTP in a p38 MAPK-dependent manner in this cell type was also unknown. We address this herein and utilize an in vitro model of asthmatic inflammation where ASM cells were stimulated with the pro-asthmatic cytokine tumor necrosis factor (TNF) and the impact of adding dexamethasone 1 h after stimulation assessed. IL-6 mRNA expression and protein secretion was significantly repressed by dexamethasone acting in a temporally distinct manner to increase MKP-1, deactivate p38 MAPK, and modulate TTP phosphorylation status. In this way, dexamethasone-induced MKP-1 acts via p38 MAPK to switch on the mRNA destabilizing function of TTP to repress pro-inflammatory cytokine secretion from ASM cells. J. Cell. Physiol. 231: 2153-2158, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  6. Spectrum of SMPD1 mutations in Asian-Indian patients with acid sphingomyelinase (ASM)-deficient Niemann-Pick disease.

    Science.gov (United States)

    Ranganath, Prajnya; Matta, Divya; Bhavani, Gandham SriLakshmi; Wangnekar, Savita; Jain, Jamal Mohammed Nurul; Verma, Ishwar C; Kabra, Madhulika; Puri, Ratna Dua; Danda, Sumita; Gupta, Neerja; Girisha, Katta M; Sankar, Vaikom H; Patil, Siddaramappa J; Ramadevi, Akella Radha; Bhat, Meenakshi; Gowrishankar, Kalpana; Mandal, Kausik; Aggarwal, Shagun; Tamhankar, Parag Mohan; Tilak, Preetha; Phadke, Shubha R; Dalal, Ashwin

    2016-10-01

    Acid sphingomyelinase (ASM)-deficient Niemann-Pick disease is an autosomal recessive lysosomal storage disorder caused by biallelic mutations in the SMPD1 gene. To date, around 185 mutations have been reported in patients with ASM-deficient NPD world-wide, but the mutation spectrum of this disease in India has not yet been reported. The aim of this study was to ascertain the mutation profile in Indian patients with ASM-deficient NPD. We sequenced SMPD1 in 60 unrelated families affected with ASM-deficient NPD. A total of 45 distinct pathogenic sequence variants were found, of which 14 were known and 31 were novel. The variants included 30 missense, 4 nonsense, and 9 frameshift (7 single base deletions and 2 single base insertions) mutations, 1 indel, and 1 intronic duplication. The pathogenicity of the novel mutations was inferred with the help of the mutation prediction software MutationTaster, SIFT, Polyphen-2, PROVEAN, and HANSA. The effects of the identified sequence variants on the protein structure were studied using the structure modeled with the help of the SWISS-MODEL workspace program. The p. (Arg542*) (c.1624C>T) mutation was the most commonly identified mutation, found in 22% (26 out of 120) of the alleles tested, but haplotype analysis for this mutation did not identify a founder effect for the Indian population. To the best of our knowledge, this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Infrastructure Engineering and Deployment Division

    Data.gov (United States)

    Federal Laboratory Consortium — Volpe's Infrastructure Engineering and Deployment Division advances transportation innovation by being leaders in infrastructure technology, including vehicles and...

  8. Situational Awareness and Logistics Division

    Data.gov (United States)

    Federal Laboratory Consortium — Volpe's Situational Awareness and Logistics Division researches, develops, implements, and analyzes advanced systems to protect, enhance, and ensure resilienceof the...

  9. Security and Emergency Management Division

    Data.gov (United States)

    Federal Laboratory Consortium — Volpe's Security and Emergency Management Division identifies vulnerabilities, risks, and opportunities to improve the security of transportation systems, critical...

  10. Systems Safety and Engineering Division

    Data.gov (United States)

    Federal Laboratory Consortium — Volpe's Systems Safety and Engineering Division conducts engineering, research, and analysis to improve transportation safety, capacity, and resiliency. We provide...

  11. Detail Design And Construction Of ''Rabbit Transfer System''

    International Nuclear Information System (INIS)

    Hasibuan, Djaruddin

    2001-01-01

    The rabbit transfer system facility is a facility that a function to decrease the transfer times of the irradiated samples from isotop cell to counting room. Base on the planning to increase the research activity and the service quality to the rabbit system user's is necessary to realized manufacturing and installation of the mention facility. The detail design purpose needs 35 m length of polypinil hose by 36 mm inner diameter and 42 mm outer diameter. By doing analysis the transfer time needs to move the sample is 3 seconds. As a reference use ASME, ASTM and AISC standard

  12. Progress report [of] Technical Physics Division

    International Nuclear Information System (INIS)

    Vijendran, P.; Deshpande, R.Y.

    1975-01-01

    Activities of the Technical Physics Division of the Bhabha Atomic Research Centre, Bombay, over the last few years are reported. This division is engaged in developing various technologies supporting the development of nuclear technology. The various fields in which development is actively being carried out are : (i) vacuum technology, (ii) mass spectrometry, (iii) crystal technology, (iv) cryogenics, and (v) magnet technology. For surface studies, the field emission microscope and the Auger electron spectrometer and other types of spectrometers have been devised and perfected. Electromagnets of requisite strength to be used in MHD programme and NMR instruments are being fabricated. Various crystals such as NaI(Tl), Ge, Fluorides, etc. required as windows and prisms in X and gamma-ray spectroscopy, have been grown. In the cryogenics field, expansion engines required for air liquefaction plants, vacuum insulated dewars, helium gas thermometers etc. have been constructed. In addition to the above, the Division provides consultancy and training to personnel from various institutions and laboratories. Equipment and systems perfected are transferred to commercial organizations for regular production. (A.K.)

  13. E-Division activities report

    International Nuclear Information System (INIS)

    Barschall, H.H.

    1979-07-01

    This report describes some of the activities in E (Experimental Physics) Division during the past year. E-Division carries out research and development in areas related to the missions of the Laboratory. Many of the activities are in pure and applied atomic and nuclear physics. In addition, this report describes work on accelerators, radiation damage, microwaves, and plasma diagnostics

  14. Developmental control of cell division

    NARCIS (Netherlands)

    Boxem, M. (Mike)

    2002-01-01

    During development of multicellular organisms, cell divisions need to be coordinated with the developmental program of the entire organism. Although the mechanisms that drive cells through the division cycle are well understood, very little is known about the pathways that link extracellular signals

  15. Division of Analytical Chemistry, 1998

    DEFF Research Database (Denmark)

    Hansen, Elo Harald

    1999-01-01

    The article recounts the 1998 activities of the Division of Analytical Chemistry (DAC- formerly the Working Party on Analytical Chemistry, WPAC), which body is a division of the Federation of European Chemical Societies (FECS). Elo Harald Hansen is the Danish delegate, representing The Danish...... Chemical Society/The Society for Analytical Chemistry....

  16. Important projects of the Division

    International Nuclear Information System (INIS)

    2008-01-01

    In this chapter important projects of the Division for Radiation Safety, NPP Decommissioning and Radwaste Management of the VUJE, a. s. are presented. Division for Radiation Safety, NPP Decommissioning and Radwaste Management has successfully carried out variety of significant projects. The most significant projects that were realised, are implemented and possible future projects are introduced in the following part of presentation.

  17. Lightning Talks 2015: Theoretical Division

    Energy Technology Data Exchange (ETDEWEB)

    Shlachter, Jack S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-25

    This document is a compilation of slides from a number of student presentations given to LANL Theoretical Division members. The subjects cover the range of activities of the Division, including plasma physics, environmental issues, materials research, bacterial resistance to antibiotics, and computational methods.

  18. 75 FR 64303 - Vermont Marble Power, Division of Omya Inc.; Central Vermont Public Service Corporation; Notice...

    Science.gov (United States)

    2010-10-19

    ..., Division of Omya Inc. (transferor) and Central Vermont Public Service Corporation (transferee) filed an... Energy Regulatory Commission Vermont Marble Power, Division of Omya Inc.; Central Vermont Public Service Corporation; Notice of Application of Transfer of Licenses, Substitution of Relicense Applicant, and...

  19. Divisions-ST Formation

    CERN Document Server

    Henny, L

    2001-01-01

    Au CERN la formation est une partie intégrante des activités de l'Organisation. Mentionnée dans le Statut du Personnel depuis l'origine, elle figure au Règlement depuis 1981 et est largement explicitée dans la Circulaire Administrative N° 16. L'organe réglementaire est constitué par la Commission Paritaire de Formation (Joint Training Board dont le sigle est JTB) qui a pour but de conseiller le Directeur Général en matière de formation, de définir la politique de formation et d'en faire l'évaluation. Des organes spécifiques ont été mis en place pour organiser les différents programmes : le Groupe Formation et Développement, le Comité exécutif de formation (sigle TEC), le Comité d'enseignement académique. Des délégués divisionnaires à la formation (sigle DTO) servent de courroie de transmission entre ces organes, le personnel et le Service de l'Enseignement (Div. HR). La Division ST dont les activités présentent une grande variété se doit de poursuivre une politique de formation s...

  20. Metals and Ceramics Division progress report for period ending December 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Craig, D.F.; Weir, J.R. Jr.

    1993-04-01

    This report provides a brief overview of the activities and accomplishments of the division, whose purpose is to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by US DOE. Activities range from basic research to industrial research and technology transfer. The division (and the report) is divided into the following: Engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials, program activities, collaborative research facilities and technology transfer, and educational programs.

  1. Transfer Pricing And Taxation Implications Disclosure In Segmental Reporting: Malaysian Evidence

    OpenAIRE

    Mohammad Talha; Syed Shah Alam; Abdullah Sallehhuddin

    2011-01-01

    Transfer pricing has emerged as common practice among highly diversified companies. Company goes for either domestic transfer pricing or international transfer pricing for several distinctive reasons. While domestic transfer pricing aims for enhancing divisional autonomy and divisions managers, international transfer pricing expects for less taxes, tariff, duties and excises. Therefore, international transfer pricing has significant taxation implication. With expansion of transfer pricing, fi...

  2. IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM.

    Science.gov (United States)

    Henness, Sheridan; van Thoor, Eveline; Ge, Qi; Armour, Carol L; Hughes, J Margaret; Ammit, Alaina J

    2006-06-01

    Human airway smooth muscle (ASM) plays an immunomodulatory role in asthma. Recently, IL-17A has become of increasing interest in asthma, being found at elevated levels in asthmatic airways and emerging as playing an important role in airway neutrophilia. IL-17A predominantly exerts its neutrophil orchestrating role indirectly via the induction of cytokines by resident airway structural cells. Here, we perform an in vitro study to show that although IL-17A did not induce secretion of the CXC chemokine IL-8 from ASM cells, IL-17A significantly potentiates TNF-alpha-induced IL-8 protein secretion and gene expression in a concentration- and time-dependent manner (P ASM cells, acting via a p38 MAPK-dependent posttranscriptional pathway to augment TNF-alpha-induced secretion of the potent neutrophil chemoattractant IL-8 from ASM cells.

  3. Flujo espiratorio máximo en niños asmáticos: Casos y controles

    Directory of Open Access Journals (Sweden)

    Arturo Recabarren Lozada

    1995-04-01

    Full Text Available Con el fin de determinar las variaciones del Flujo Espiratorio Máximo (PEF, se estudiaron a 38 niños asmáticos (CASOS en período intercrítico de la enfermedad y a 38 niños sanos (CONTROLES, de ambos sexos comprendidos entre los 5 y 15 años de edad. Los niños asmáticos fueron clasificados por parámetros clínicos en determinado grado de severidad de asma bronquial, determinando el PEF de cada niño objeto de estudio conel mini-Wright Peak Flow Meter, en 2 registros diarios a los 06 y 18 horas, durante 7 días consecutivos, obteniendo la variabilidad del mismo. Se encuentra diferencia en la variabilidad global de niños asmáticos de todos los grados de severidad de la enfermedad comprada con la de los niños normales, con diferencia estadística altamente significativa (p<0.000001. Las variaciones diurnas del PEF ayuda en el diagnóstico del asma bronquial y también son útiles para realizar la catalogación de severidad de la enfermedad. El PEF correlaciona bien con los síntomas presentados por los pacientes y por lo tanto guarda correspondencia con la Hiperreactividad bronquial (HRB del niño asmático. Postulamos que un niño con historia clínica sugestiva, una variabilidad global mayor del 8% indica que el diagnóstico de asma es altamente probable (Rev Med Hered 1995; 6: 76-82

  4. ASME B89.4.19 Performance Evaluation Tests and Geometric Misalignments in Laser Trackers

    Directory of Open Access Journals (Sweden)

    Muralikrishnan, Bala

    2009-01-01

    Full Text Available Small and unintended offsets, tilts, and eccentricity of the mechanical and optical components in laser trackers introduce systematic errors in the measured spherical coordinates (angles and range readings and possibly in the calculated lengths of reference artifacts. It is desirable that the tests described in the ASME B89.4.19 Standard [1] be sensitive to these geometric misalignments so that any resulting systematic errors are identified during performance evaluation. In this paper, we present some analysis, using error models and numerical simulation, of the sensitivity of the length measurement system tests and two-face system tests in the B89.4.19 Standard to misalignments in laser trackers. We highlight key attributes of the testing strategy adopted in the Standard and propose new length measurement system tests that demonstrate improved sensitivity to some misalignments. Experimental results with a tracker that is not properly error corrected for the effects of the misalignments validate claims regarding the proposed new length tests.

  5. Interim status report on the revision of ASME PTC 12.1 -- closed feedwater heaters

    International Nuclear Information System (INIS)

    Stellern, J.L.; Hoobler, J.V.; Milton, J.W.; Welch, T.; Kona, C.; Thompson, H.N.; Tsou, J.L.

    1993-01-01

    The ASME Performance Test Code (PTC) 12.1-1978 for the performance testing of feedwater heaters is being revised extensively and updated. The committee anticipates that the final draft of the proposed Code will be ready for industry review in 1993. This Code revision will greatly enhance the usefulness and cost effectiveness of feedwater heater performance testing. This paper has been prepared to report on the progress of the committee and to disseminate information on the nature of the revision. Included in this paper are some of the notable changes intended for the Code. The most extensive change is the calculation method, which is described in step-by-step detail. An approach is also described for using ultrasonic flow techniques to test individual or split-string feedwater heaters, when flow nozzles are not available. Additionally some educational information on the use and limitations of ultrasonic measurement instrumentation is included. Discussion is also included on the required uncertainty analysis. 3 refs., 2 figs., 2 tabs

  6. ASM-Triggered Too Observations of Kilohertz Oscillations in Three Atoll Sources

    Science.gov (United States)

    Kaaret, P.; Swank, Jean (Technical Monitor)

    2000-01-01

    Three Rossi Timing Explorer (RXTE) observations were carried out for this proposal based on target of opportunity triggers derived from the All-Sky Monitor (ASM) on RXTE. We obtained short observations of 4U1636-536 (15ks) and 4U1735-44 (23ks) and a longer observation of 4U0614+091 (117ks). Our analysis of our observations of the atoll neutron star x-ray binary 4U1735-44 lead to the discovery of a second high frequency quasiperiodic oscillation (QPO) in this source. These results were published in the Astrophysical Journal Letters. The data obtained on the source 4U0614+091 were used in a comprehensive study of this source, which will be published in the Astrophysical Journal. The data from this proposal were particularly critical for that study as they lead to the detection of the highest QPO frequency every found in the x-ray emission from an x-ray binary which will be important in placing limits on the equation of state of nuclear matter.

  7. 2016 ASMS Workshop Review: Next Generation LC/MS: Critical Insights and Future Perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Hongying; Makarov, Alexander; Smith, Richard D.

    2017-04-17

    The pilot workshop on BNext Generation LC/MS: Critical Insights and Future Perspectives was held on the evening of June 6, 2016 at the 64th ASMS Conference on Mass Spectrometry and Allied Topics held in San Antonio, TX. The workshop, chaired by Hongying Gao (Pfizer), consisted of stimulating talks from distinguished speakers and open discussion among the audience and invited presenters.The objectives of this workshop were to better understand the advances and limitations of current technologies; to exchange perspectives on the next generation LC/MS; and to discuss/debate the features of next generation LC/MS focusing on the following three questions: (1) What would the next generation LC/MS look like? (2) How would it change the way we do analysis? and (3) What fundamental issues need to be resolved? A real-world case in the biopharmaceutical industry was presented by Hongying Gao on the needs by industry for LC/MS innovation and technology advancements. The primary invited speakers were Alexander Makarov (Thermo Fisher Scientific) and Richard (Dick) Smith (Pacific Northwest National Laboratory). The open discussions started with Q&A and comments for Alexander Makarov and Dick Smith, followed by insights and perspectives from members of the audience and other invited presenters who shared their thoughts addressing the above questions.

  8. Section XI of the ASME code: A new approach to qualifying procedures and personnel

    International Nuclear Information System (INIS)

    Chokie, L.J.

    1985-01-01

    Following the results of numerous programs and trials which measured the effectiveness of the nondestructive examinations required by Section XI of the ASME Code on Nuclear Inservice Inspection of Nuclear Power Plant Components, revisions have been made to the Code to improve the over-all reliability. The results of the round-robin programs designed to measure the reliability of detection and the reliability of correctly sizing the flaws indicated that the rather specific requirements in Section XI did not always achieve the desired results in both heavy section pressure vessel steels, nor in austenitic stainless steel piping welds. One of the two major contributors to the less-than-desired reliability was identified as being the training, understanding and qualification of the personnel; the other was principally due to the fact that the exact methods specified in the Code were not always applicable on every steel or every weld joint configuration. Revisions to the Code were proposed and approved to address these deficiencies, and which revisions have been issued for immediate implementation. The new approach is to permit any procedure or method to be used provided the procedure can be qualified on actual specimens containing the type of flaws to be detected, and following the qualification of the procedure, the personnel must be trained and qualified to obtain a certain level of proficiency using the qualified procedure on actual samples. The qualification of each procedure and each individual is required before examining an actual nuclear plant

  9. The application of RCM to ASME code requirements for in-service testing

    International Nuclear Information System (INIS)

    Rowley, C.W.

    1990-01-01

    This paper reports that the high reliability of nuclear power plant systems and components is highly important for both nuclear safety and electrical power production economics. The optimum operating performance of these plant systems and components is heavily dependent on the original or modified design for its inherent reliability and the appropriate trade-off in preventive and corrective maintenance for its developed reliability. In developing this optimum operating performance goal, the plant staff could rely solely on the experience of its personnel. However using this internal subjective approach, the average nuclear power availability has been far less than 80%. Obviously the production economics of a nuclear power plant is the province of the owner-operator, but the safety system and component performance impacts the entire industry. Hence the nuclear industry needs to have in-service testing requirements that maintain the necessary safety standards. Historically the ASME Inservice Testing Code has been a vehicle for defining some of those necessary safety standards, such as inservice testing of pumps, valves, and snubbers. The nuclear industry needs to expand the code testing to include all the systems that affect these necessary safety standards

  10. ASPEK PERPAJAKAN DALAM PRAKTEK TRANSFER PRICING

    Directory of Open Access Journals (Sweden)

    Yenni Mangoting

    2000-01-01

    Full Text Available Transfer pricing is defined as a special price for sale that is used in exchange of interdivisional to record the revenue of the selling division and expense of the buying division. The main goal of transfer pricing is to evaluate and measure the performance of a company. But transfer pricing is often used by multinational companies to minimize tax paid through the re-engineering of price transferred among divisions. The key to a successful practice of transfer pricing from tax standpoint is the existence of related parties transactions. Related parties is relationship between one company with other company and this relationship happens because of such relationship between each company does not exist naturally.To regulate the tranfer pricing practice, the regulations govern the authority to realocate transfer price among divisions that have related parties transactions. Abstract in Bahasa Indonesia : Transfer pricing didefenisikan sebagai suatu harga jual khusus yang dipakai dalam pertukaran antardivisional untuk mencatat pendapatan divisi penjual (selling division dan biaya divisi pembeli (buying division. Tujuan utama dari transfer pricing adalah mengevaluasi dan mengukur kinerja perusahaan. Tetapi sering juga transfer pricing digunakan oleh perusahaan-perusahaan multinasional untuk meminimalkan jumlah pajak yang dibayar melalui rekayasa harga yang ditransfer antardivisi. Kunci utama keberhasilan transfer pricing dari sisi pajak adalah adanya transaksi karena adanya hubungan istimewa. Hubungan istimewa merupakan hubungan kepemilikan antara satu perusahaan dengan perusahaan lain dan hubungan ini terjadi karena adanya keterkaitan satu pihak dengan pihak lain yang tidak terdapat pada hubungan biasa. Untuk mengatur transfer pricing ini, undang-undang memberikan kewenangan kepada pihak fiskus untuk menentukan kembali jumlah harga transfer antar pihak-pihak yang mempunyai hubungan istimewa. Kata kunci: transfer pricing, hubungan istimewa, perusahaan

  11. Iterative and non-iterative solutions of engine flows using ASM and k-ε turbulence models

    International Nuclear Information System (INIS)

    Khaleghi, H.; Fallah, E.

    2003-01-01

    Various turbulent models are widely developed in order to make a good prediction of turbulence phenomena in different applications. The standard k-ε model shows a poor prediction for some applications. The Reynolds Stress Model (RSM) is expected to give a better prediction of turbulent characteristics, because a separate differential equation for each Reynolds stress component is solved in this model. In order to save both time and memory in this calculation a new Algebraic Stress Model (ASM) which was developed by Lumly et al in 1995 is used for calculations of flow characteristics in the internal combustion engine chamber. With using turbulent realizability principles, this model becomes a powerful and reliable turbulence model. In this paper the abilities of the model is examined in internal combustion engine flows. The results of ASM and k-ε models are compared with the experimental data. It is shown that the poor predictions of k-ε model are modified by ASM model. Also in this paper non-iterative PISO and iterative SIMPLE solution algorithms are compared. The results show that the PISO solution algorithm is the preferred and more efficient procedure in the calculation of internal combustion engine. (author)

  12. Elastic-plastic stress analysis and ASME code evaluation of a bottomhead penetration in a reactor pressure vessel

    International Nuclear Information System (INIS)

    Ranganath, S.

    1979-01-01

    Nuclear pressure vessel components are designed to meet the requirements of Section III of the ASME Boiler and Pressure Vessel Code. Specifically, the design must satisfy the limits on stress range and fatigue usage prescribed in NB-3200, Section III ASME Code for the various design and operating conditions for the component. The Code requirements assure that the component does not experience gross yielding and that in general, elastic shakedown occurs following cyclic loading. When elastic stress analysis is performed this can be shown by meeting the limits in the Code on Primary and Primary plus Secondary (P+Q) stress intensities. However, when the P+Q limits cannot be met and elastic Shakedown cannot be demonstrated, plastic analysis may be performed to meet the requirements of the Code. This paper describes the elastic-plastic stress analysis of a Boiling Water Reactor Vessel bottom head in-core penetration and illustrates how plastic analysis can be used in ASME Code evaluations to show Code compliance. Details of the thermal analysis, elastic-plastic stress analysis and fatigue evaluation are presented and it is shown that the in-core penetration satisfies the code requirements. 6 refs

  13. Statistical re-evaluation of the ASME K{sub IC} and K{sub IR} fracture toughness reference curves

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K.; Rintamaa, R. [Valtion Teknillinen Tutkimuskeskus, Espoo (Finland)

    1998-11-01

    Historically the ASME reference curves have been treated as representing absolute deterministic lower bound curves of fracture toughness. In reality, this is not the case. They represent only deterministic lower bound curves to a specific set of data, which represent a certain probability range. A recently developed statistical lower bound estimation method called the `Master curve`, has been proposed as a candidate for a new lower bound reference curve concept. From a regulatory point of view, the Master curve is somewhat problematic in that it does not claim to be an absolute deterministic lower bound, but corresponds to a specific theoretical failure probability that can be chosen freely based on application. In order to be able to substitute the old ASME reference curves with lower bound curves based on the master curve concept, the inherent statistical nature (and confidence level) of the ASME reference curves must be revealed. In order to estimate the true inherent level of safety, represented by the reference curves, the original data base was re-evaluated with statistical methods and compared to an analysis based on the master curve concept. The analysis reveals that the 5% lower bound Master curve has the same inherent degree of safety as originally intended for the K{sub IC}-reference curve. Similarly, the 1% lower bound Master curve corresponds to the K{sub IR}-reference curve. (orig.)

  14. Development and application of proposed ASME Section XI Code changes for risk-based inspection of piping

    International Nuclear Information System (INIS)

    West, R.A.

    1996-01-01

    This synopsis has been written to describe a perspective on the development and application of ASME Section XI Code changes for risk-based inspection of piping. The content is specifically related to the use of risk-based technology for Inservice Inspection (ISI) of piping and efforts made to support the ASME Research/Westinghouse Owners Group/Millstone Unit 3 approach for use of this technology. The opinions contained herein may or may not reflect those of the ASME Codes and Standards Committees responsible for these activities. In order to take such a detailed technical subject and put it into an understandable format, the author has chosen to provide an analogy to simplify what is actually taking place. Risk-based technology in the ISI of piping can be likened to the process of making and using specifically ground prescription glasses to allow for better vision. It provides a process to develop and use these uniquely ground glasses that will dynamically focus on all the locations and obstacles within a plant's piping systems that could cause that plant to trip and fall; more importantly it identifies the locations where the fall could possibly hurt someone else. In this way, Nuclear Safety is being addressed

  15. Modeling a bench-scale alternating aerobic/anoxic activated sludge system for nitrogen removal using a modified ASM1.

    Science.gov (United States)

    Kim, Hyunook; Noh, Soohong; Colosimo, Mark

    2009-07-01

    The Activated Sludge Model No. 1 (ASM1), developed by The International Association of Water Pollution Research and Control, was applied to model dynamics of NH4+, and NO3- in a bench scale alternating aerobic-anoxic (AAA) activated sludge system for nitrogen removal. The model was modified by eliminating inert soluble COD (S(I)) and inert particulate COD (X(I)) from the model's state variables as these two variables are not involved in any biological reaction and are not readily measurable with conventional routine COD analysis. It was assumed that the soluble COD and particulate COD of wastewater represent readily biodegradable COD (S(S)) and slowly biodegradable (X(S)) in the model, respectively. In addition, alkalinity was also removed from the model, since alkalinity of an AAA system remains stable due to the cyclic modes of the system. Even with the elimination of the three state variables and the assumption made, the model could reasonably predict the NH4+ and NO3- dynamics of the AAA system, and effluent NH4+ and NO3- concentrations with adjustment of only a few kinetic parameters. Compared to the original ASM1, it is expected that the modified ASM1 presented in this study can be more easily utilized by engineers in designing or operating an AAA system in practice, since it requires simple characterization of wastewater COD.

  16. Función adrenal y metabolismo lipídico en niños asmáticos tratados con budesonida

    Directory of Open Access Journals (Sweden)

    Paoli-de Valeri Mariela

    1999-01-01

    Full Text Available Objetivo. Evaluar el efecto de bajas dosis de budesonida inhalado sobre la función adrenal y el metabolismo lipídico en niños asmáticos. Material y métodos. Se estudiaron: 10 niños asmáticos (edad promedio, 8.6 años tratados con budesonida inhalado (200-300 µg/día por un lapso mayor a tres meses (grupo A; 15 niños asmáticos (edad promedio, 7.8 años sin tratamiento esteroideo (grupo B, y 10 niños no asmáticos (grupo C. Se determinaron los niveles de cortisol basal y postestímulo con ACTH, andrógenos adrenales, lípidos y cortisol urinario. Resultados. Entre los grupos A y B no hubo diferencias significativas en las variables estudiadas. En los niños asmáticos (grupo A-B el cortisol urinario fue significativamente mayor en relación con el grupo C. Los niveles de triglicéridos, colesterol total, colesterol de la lipoproteína de baja densidad e índices aterogénicos fueron mayores en el grupo de niños asmáticos, con y sin budesonida, comparados con el grupo C. Conclusiones. El tratamiento con dosis bajas de budesonida inhalado en niños asmáticos no modificó la función del eje adrenal ni el metabolismo lipídico. Los pacientes asmáticos presentaron un perfil lipídico aterogénico que podría incrementar el riesgo de enfermedad cardiovascular.

  17. The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study.

    Science.gov (United States)

    Queille-Roussel, C; Paul, C; Duteil, L; Lefebvre, M C; Rapatz, G; Zagula, M; Ortonne, J P

    2001-03-01

    SDZ ASM 981 is a selective inhibitor of inflammatory cytokines released from T lymphocytes and mast cells, which has been developed for the treatment of inflammatory skin diseases. In the present study, the atrophogenic potential of SDZ ASM 981 1% cream in humans was compared with that of medium and highly potent topical steroids, and vehicle. Four different preparations, SDZ ASM 981 1% cream, the corresponding vehicle of SDZ ASM 981 1% cream, betamethasone-17-valerate 0.1% cream and triamcinolone acetonide 0.1% cream, were applied to the volar aspect of the forearms of 16 healthy volunteers, twice daily, 6 days a week, for 4 weeks. Skin thickness was evaluated by ultrasound examination, clinical signs of atrophy by stereomicroscopy, and epidermal thickness was assessed by histology. Both topical corticosteroids induced a significant reduction in skin thickness, as compared with SDZ ASM 981 1% cream and vehicle, which were shown to be equivalent. The difference in skin thickness (measured by ultrasound examination) between patients treated with SDZ ASM 981 1% cream and those receiving either of the two topical steroids was significant from day 8 onwards. Histological analysis performed at day 29 showed significant epidermal thinning with topical steroids compared with SDZ ASM 981 1% cream or the vehicle. Conclusion The lack of atrophogenic properties of SDZ ASM 981 1% cream in this short-term study demonstrates its potential as long-term treatment for inflammatory skin diseases, thus overcoming a major drawback of topical steroids. This may also be important for the treatment of children, and sensitive areas of skin, such as the face and skin-folds.

  18. Physics division annual report 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Glover, J.; Physics

    2008-02-28

    This report highlights the activities of the Physics Division of Argonne National Laboratory in 2006. The Division's programs include the operation as a national user facility of ATLAS, the Argonne Tandem Linear Accelerator System, research in nuclear structure and reactions, nuclear astrophysics, nuclear theory, investigations in medium-energy nuclear physics as well as research and development in accelerator technology. The mission of nuclear physics is to understand the origin, evolution and structure of baryonic matter in the universe--the core of matter, the fuel of stars, and the basic constituent of life itself. The Division's research focuses on innovative new ways to address this mission.

  19. Draft ASME Boiler and Pressure Vessel Code Section III, Division 5, Section HB, Subsection B, Code Case for Alloy 617 and Background Documentation

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Julie Knibloe [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-08-01

    Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor. To evaluate the behavior of this material in the expected service conditions, strain controlled cyclic tests that include long hold times up to 240 minutes at maximum tensile strain were conducted at 850°C. In terms of the total number of cycles to failure, the fatigue resistance decreased when a hold time was added at peak tensile strain. Increases in the tensile hold duration degraded the creep fatigue resistance, at least to the investigated strain controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. The creep fatigue deformation mode is considered relative to the lack of saturation, or continually decreasing number of cycles to failure with increasing hold times. Additionally, preliminary values from the 850°C creep fatigue data are calculated for the creep fatigue damage diagram and have higher values of creep damage than those from tests at 950°C.

  20. Annual report of the Division of High Temperature Engineering

    International Nuclear Information System (INIS)

    1982-10-01

    Research activities conducted in the Division of High Temperature Engineering during fiscal 1981 are described. R and D works of our division are mainly related to a multi-purpose very high-temperature gas-cooled reactor (VHTR) and a fusion reactor. This report deals with the main results obtained on material test, development of computer codes, heat transfer, fluid-dynamics, structural mechanics and the construction of an M + A (Mother and Adapter) section of a HENDEL (Helium Engineering Demonstration Loop) as well. (author)

  1. E-Division activities report

    International Nuclear Information System (INIS)

    Barschall, H.H.

    1984-07-01

    E (Experimental Physics) Division carries out basic and applied research in atomic and nuclear physics, in materials science, and in other areas related to the missions of the Laboratory. Some of the activities are cooperative efforts with other divisions of the Laboratory, and, in a few cases, with other laboratories. Many of the experiments are directly applicable to problems in weapons and energy, some have only potential applied uses, and others are in pure physics. This report presents abstracts of papers published by E (Experimental Physics) Division staff members between July 1983 and June 1984. In addition, it lists the members of the scientific staff of the division, including visitors and students, and some of the assignments of staff members on scientific committees. A brief summary of the budget is included

  2. Computers in Nuclear Physics Division

    International Nuclear Information System (INIS)

    Kowalczyk, M.; Tarasiuk, J.; Srebrny, J.

    1997-01-01

    Improving of the computer equipment in Nuclear Physics Division is described. It include: new computer equipment and hardware upgrading, software developing, new programs for computer booting and modernization of data acquisition systems

  3. Metals and Ceramics Division progress report for period ending December 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Craig, D.F.; Bradley, R.A.; Weir, J.R. Jr.

    1994-07-01

    This report provides an overview of activities and accomplishsments of the division from October 1992 through December 1993; the division is organized to provide technical support, mainly in the area of high-temperature materials, for technologies being developed by DOE. Activities span the range from basic research to industrial interactions (cooperative research and technology transfer). Sections 1-5 describe the different functional groups (engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials). Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines. Sect. 7 summarizes external interactions including cooperative R and D programs and technology transfer functions. Finally, Sect. 8 briefly describes the division`s involvement in educational activities. Several organizational changes were effected during this period.

  4. A literature survey on numerical heat transfer

    Science.gov (United States)

    Shih, T. M.

    1982-12-01

    Technical papers in the area of numerical heat transfer published from 1977 through 1981 are reviewed. The journals surveyed include: (1) ASME Journal of Heat Transfer, (2) International Journal of Heat and Mass Transfer, (3) AIAA Journal, (4) Numerical Heat Transfer, (5) Computers and Fluids, (6) International Journal for Numerical Methods in Engineering, (7) SIAM Journal of Numerical Analysis, and (8) Journal of Computational Physics. This survey excludes experimental work in heat transfer and numerical schemes that are not applied to equations governing heat transfer phenomena. The research work is categorized into the following areas: (A) conduction, (B) boundary-layer flows, (C) momentum and heat transfer in cavities, (D) turbulent flows, (E) convection around cylinders and spheres or within annuli, (F) numerical convective instability, (G) radiation, (H) combustion, (I) plumes, jets, and wakes, (J) heat transfer in porous media, (K) boiling, condensation, and two-phase flows, (L) developing and fully developed channel flows, (M) combined heat and mass transfer, (N) applications, (O) comparison and properties of numerical schemes, and (P) body-fitted coordinates and nonuniform grids.

  5. An ASM/ADM model interface for dynamic plant-wide simulation.

    Science.gov (United States)

    Nopens, Ingmar; Batstone, Damien J; Copp, John B; Jeppsson, Ulf; Volcke, Eveline; Alex, Jens; Vanrolleghem, Peter A

    2009-04-01

    Mathematical modelling has proven to be very useful in process design, operation and optimisation. A recent trend in WWTP modelling is to include the different subunits in so-called plant-wide models rather than focusing on parts of the entire process. One example of a typical plant-wide model is the coupling of an upstream activated sludge plant (including primary settler, and secondary clarifier) to an anaerobic digester for sludge digestion. One of the key challenges when coupling these processes has been the definition of an interface between the well accepted activated sludge model (ASM1) and anaerobic digestion model (ADM1). Current characterisation and interface models have key limitations, the most critical of which is the over-use of X(c) (or lumped complex) variable as a main input to the ADM1. Over-use of X(c) does not allow for variation of degradability, carbon oxidation state or nitrogen content. In addition, achieving a target influent pH through the proper definition of the ionic system can be difficult. In this paper, we define an interface and characterisation model that maps degradable components directly to carbohydrates, proteins and lipids (and their soluble analogues), as well as organic acids, rather than using X(c). While this interface has been designed for use with the Benchmark Simulation Model No. 2 (BSM2), it is widely applicable to ADM1 input characterisation in general. We have demonstrated the model both hypothetically (BSM2), and practically on a full-scale anaerobic digester treating sewage sludge.

  6. Isolation and characterization of plantaricin ASM1: a new bacteriocin produced by Lactobacillus plantarum A-1.

    Science.gov (United States)

    Hata, Tomomi; Tanaka, Rie; Ohmomo, Sadahiro

    2010-01-31

    Bacteriocins produced by lactic acid bacteria showing stability even in neutral and weak alkaline pH were screened, and a new bacteriocin produced by Lactobacillus plantarum A-1, plantaricin ASM1 (PASM1) was purified and characterized. This bacteriocin which is heat-stable but digested by trypsin inhibits the growth of lactic acid bacterial species, such as Lactobacillus, Leuconostoc, and Enterococcus. PASM1 showed stability in a wide pH range compared to nisin A. The bacteriocin was purified using cation exchange, hydrophobic interaction, and reverse-phase high-performance liquid chromatography. The activity of the purified bacteriocin was obtained as one fraction. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of the fraction showed a mass of 5045.7Da. Combining the data obtained from amino acid and DNA sequencing, the primary sequence of PASM1 was determined. The sequence of the corresponding gene revealed that the peptide is ribosomally synthesized as a 64 amino acid precursor containing a 21 amino acid N-terminal extension of the double-glycine type. The mature peptide consists of 43 amino acids, which could contain two intramolecular disulfide bonds in the structure. Three putative open reading frames were located upstream of the PLNA1 gene. These genes may encode the thioredoxin family proteins and a response regulator both of which have been suggested to regulate expression of the PASM1 gene and the processing of its leader peptide. PASM1 has no reported homologue bacteriocins. Stability in a wide pH range and heat indicates its potential for application in food preservation. Copyright 2009 Elsevier B.V. All rights reserved.

  7. Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma.

    Science.gov (United States)

    Boulet, Louis-Philippe; Gauvreau, Gail M; Cockcroft, Donald W; Davis, Beth; Vachon, Luc; Cormier, Yvon; O'Byrne, Paul M

    2015-01-01

    To evaluate the safety, tolerability and clinical activity of ASM-024, a new cholinergic compound with dual nicotinic and muscarinic activity, in mild allergic asthma. The present study involved 24 stable, mild allergic asthmatic subjects. In a cross-over design, ASM-024 (50 mg or 200 mg) or placebo were administered once daily by nebulization over three periods of nine consecutive days separated by a three-week washout. The effect of each treatment on the forced expiratory volume in 1 s (FEV1), provocative concentration of methacholine causing a 20% decline in FEV1 (PC20), early and late asthmatic responses, and allergen-induced inflammation were measured. Seventeen subjects completed the study. During treatment with ASM-024 at 50 mg or 200 mg, the PC20 value increased respectively from a mean (± SD) 2.56±3.86 mg/mL to 4.11 mg/mL (P=0.007), and from 3.12±4.37 mg/mL to 5.23 mg/mL (P=0.005) (no change with placebo). On day 7 (day preceding allergen challenge), postdosing FEV1 increased by 2.0% with 50 mg (P=0.005) and 1.9% with 200 mg (P=0.008) (placebo -1.1%). ASM-24 had no inhibitory effect on early and late asthmatic responses, nor on sputum eosinophil or neutrophil levels. ASM-024 induced no serious adverse events, but caused cough in 22% and 48% of the subjects with 50 mg and 200 mg, respectively, compared with 10% who were on placebo. ASM-024 did not inhibit allergen-induced asthmatic response and related airway inflammation, but reduced methacholine airway responsiveness and slightly improved lung function. The mechanism by which ASM-024 improves these outcomes requires further study.

  8. Beyond Cookies: Understanding Various Division Models

    Science.gov (United States)

    Jong, Cindy; Magruder, Robin

    2014-01-01

    Having a deeper understanding of division derived from multiple models is of great importance for teachers and students. For example, students will benefit from a greater understanding of division contexts as they study long division, fractions, and division of fractions. The purpose of this article is to build on teachers' and students'…

  9. Technical activities, 1990: Surface Science Division

    International Nuclear Information System (INIS)

    Powell, C.J.

    1991-05-01

    The report summarizes technical activities and accomplishments of the NIST Surface Science Division during Fiscal Year 1990. Overviews are presented of the Division and of its three constituent groups: Surface Dynamical Processes, Thin Films and Interfaces, and Surface Spectroscopies and Standards. These overviews are followed by reports of selected technical accomplishments during the year. A summary is given of Division outputs and interactions that includes lists of publications, talks, committee assignments, seminars (including both Division seminars and Interface Science seminars arranged through the Division), conferences organized, and a standard reference material certified. Finally, lists are given of Division staff and of guest scientists who have worked in the Division during the past year

  10. Fueling the Cell Division Cycle.

    Science.gov (United States)

    Salazar-Roa, María; Malumbres, Marcos

    2017-01-01

    Cell division is a complex process with high energy demands. However, how cells regulate the generation of energy required for DNA synthesis and chromosome segregation is not well understood. Recent data suggest that changes in mitochondrial dynamics and metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis crosstalk with, and are tightly regulated by, the cell division machinery. Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism. Some of these connections are altered in human disease, and their manipulation may help in designing therapeutic strategies for specific diseases including cancer. We review here recent studies describing the control of metabolism by the cell-cycle machinery. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Towards a consensus-based biokinetic model for green microalgae - The ASM-A.

    Science.gov (United States)

    Wágner, Dorottya S; Valverde-Pérez, Borja; Sæbø, Mariann; Bregua de la Sotilla, Marta; Van Wagenen, Jonathan; Smets, Barth F; Plósz, Benedek Gy

    2016-10-15

    Cultivation of microalgae in open ponds and closed photobioreactors (PBRs) using wastewater resources offers an opportunity for biochemical nutrient recovery. Effective reactor system design and process control of PBRs requires process models. Several models with different complexities have been developed to predict microalgal growth. However, none of these models can effectively describe all the relevant processes when microalgal growth is coupled with nutrient removal and recovery from wastewaters. Here, we present a mathematical model developed to simulate green microalgal growth (ASM-A) using the systematic approach of the activated sludge modelling (ASM) framework. The process model - identified based on a literature review and using new experimental data - accounts for factors influencing photoautotrophic and heterotrophic microalgal growth, nutrient uptake and storage (i.e. Droop model) and decay of microalgae. Model parameters were estimated using laboratory-scale batch and sequenced batch experiments using the novel Latin Hypercube Sampling based Simplex (LHSS) method. The model was evaluated using independent data obtained in a 24-L PBR operated in sequenced batch mode. Identifiability of the model was assessed. The model can effectively describe microalgal biomass growth, ammonia and phosphate concentrations as well as the phosphorus storage using a set of average parameter values estimated with the experimental data. A statistical analysis of simulation and measured data suggests that culture history and substrate availability can introduce significant variability on parameter values for predicting the reaction rates for bulk nitrate and the intracellularly stored nitrogen state-variables, thereby requiring scenario specific model calibration. ASM-A was identified using standard cultivation medium and it can provide a platform for extensions accounting for factors influencing algal growth and nutrient storage using wastewater resources. Copyright

  12. Reactor Engineering Division annual report

    International Nuclear Information System (INIS)

    Matsuura, Shojiro; Nakahara, Yasuaki; Takano, Hideki

    1982-09-01

    Research and development activities in the Division of Reactor Engineering in fiscal 1981 are described. The work of the Division is closely related to development of multipurpose Very High Temperature Gas Cooled Reactor and fusion reactor, and development of Liquid Metal Fast Breeder Reactor carried out by Power Reactor and Nuclear Fuel Development Corporation. Contents of the report are achievements in fields such as nuclear data and group constants, theoretical method and code development, integral experiment and analysis, shielding, reactor and nuclear instrumentation, reactor control and diagnosis, and fusion reactor technology, and activities of the Committee on Reactor Physics. (author)

  13. Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

    International Nuclear Information System (INIS)

    Hoge, K.G.

    1976-01-01

    A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

  14. Comparisons of ASME-code fatigue-evaluation methods for nuclear Class 1 piping with Class 2 or 3 piping

    International Nuclear Information System (INIS)

    Rodabaugh, E.C.

    1983-06-01

    The fatigue evaluation procedure used in the ASME Boiler and Pressure Vessel Code, Sect. III, Nuclear Power Plant Components, for Class 1 piping is different from the procedure used for Class 2 or 3 piping. The basis for each procedure is described, and correlations between the two procedures are presented. Conditions under which either procedure or both may be unconservative are noted. Potential changes in the Class 2 or 3 piping procedure to explicitly cover all loadings are discussed. However, the report is intended to be informative, and while the contents of the report may guide future Code changes, specific recommendations are not given herein

  15. Acid sphingomyelinase (Asm) deficiency patients in The Netherlands and Belgium: disease spectrum and natural course in attenuated patients.

    Science.gov (United States)

    Hollak, C E M; de Sonnaville, E S V; Cassiman, D; Linthorst, G E; Groener, J E; Morava, E; Wevers, R A; Mannens, M; Aerts, J M F G; Meersseman, W; Akkerman, E; Niezen-Koning, K E; Mulder, M F; Visser, G; Wijburg, F A; Lefeber, D; Poorthuis, B J H M

    2012-11-01

    Niemann-Pick disease (NPD) is a neurovisceral lysosomal storage disorder caused by acid sphingomyelinase (ASM) deficiency, which can be categorized as either Niemann-Pick disease type A [NPD-A], with progressive neurological disease and death in early childhood, or as Niemann-Pick disease type B [NPD-B], with a more variable spectrum of manifestations. Enzyme replacement therapy (ERT) with recombinant sphingomyelinase is currently studied as potential treatment for NPD-B patients. The objective of this study is to characterize the clinical features of patients with ASM deficiency in the Netherlands and Belgium with focus on the natural disease course of NPD-B patients. Prospective and retrospective data on ASM deficient patients were collected in The Netherlands and part of Belgium. Patients with NPD-B that could be followed prospectively were evaluated every 6-12 months for pulmonary function tests, 6 minute walk test (6 MWT), imaging (bone marrow infiltration measured by QCSI, organ volumes by MRI and CT scan of the lungs) and biochemical markers. Twenty-five patients with ASM deficiency were identified (13 males, 12 females, median age 13years, range 1-59 years). Nine patients had died at the time of the study, including four NPD-A patients at the age of 1,1, 2, 3 and five NPDB patents at the age of 5, 6, 43, 56 and 60 years. There was a high prevalence of homozygosity and compound heterozygosity for the common p.Arg608del mutation in 43% and 19% of NPD-B patients, respectively. In NPD-B patients, thrombocytopenia was present in most, while anemia and leucopenia were less common (33% and 6 % respectively). HDL cholesterol was reduced in most patients. Pulmonary disease was severe in several patients. Follow-up up to 11 years revealed a gradual decrease in platelet count. Detailed investigations in 6 NPD-B patients with follow-up in 4 patients revealed remarkable stable disease parameters up to 6 years, with some decline in pulmonary function and 6 MWT. Bone

  16. Division of Information Technology - Overview

    International Nuclear Information System (INIS)

    Szlachciak, J.

    2007-01-01

    I have a great pleasure to introduce the youngest division in our Institute, namely the Division of Information Technology. The division was created in 2005, but this is the first time when it reports its activities. The main purpose of creation was a better management of al IT activities in different departments, lowering IT costs and increase security over all computer systems used be the Institute. Although we have started with small human resources, we have received a big support from other departments. Special thanks go to the Department of Detectors and Nuclear Electronics. Our division handles many service-oriented activities. In daily work we answer many IT-related questions and deliver our help in order to solve hardware and software problems. The style of our work can be described as a result-oriented one. Here is the list of our biggest achievements: · construction of the server room; · implementation of two electronic bank systems; · development of the dynamic hardware and software inventory system; · development of the Scientific Activity Database. (author)

  17. Environmental Transport Division: 1979 report

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, C.E. Jr.; Schubert, J.F.; Bowman, W.W.; Adams, S.E.

    1980-03-01

    During 1979, the Environmental Transport Division (ETD) of the Savannah River Laboratory conducted atmospheric, terrestrial, aquatic, and marine studies, which are described in a series of articles. Separate abstracts were prepared for each. Publications written about the 1979 research are listed at the end of the report.

  18. Environmental Transport Division: 1979 report

    International Nuclear Information System (INIS)

    Murphy, C.E. Jr.; Schubert, J.F.; Bowman, W.W.; Adams, S.E.

    1980-03-01

    During 1979, the Environmental Transport Division (ETD) of the Savannah River Laboratory conducted atmospheric, terrestrial, aquatic, and marine studies, which are described in a series of articles. Separate abstracts were prepared for each. Publications written about the 1979 research are listed at the end of the report

  19. Nuclear Physics division progress report

    International Nuclear Information System (INIS)

    Lees, E.W.; Longworth, G.; Scofield, C.J.

    1981-07-01

    Work undertaken by the Nuclear Physics Division of AERE, Harwell during 1980 is presented under the headings: (1) Nuclear Data and Technology for Nuclear Power. (2) Nuclear Studies. (3) Applications of Nuclear and Associated Techniques. (4) Accelerator Operation, Maintenance and Development. Reports, publications and conference papers presented during the period are given and members of staff listed. (U.K.)

  20. 75 FR 16178 - Antitrust Division

    Science.gov (United States)

    2010-03-31

    ..., 15 U.S.C. 4301 et seq. (``the Act''), Joint Venture Agreement Between Cambridge Major Laboratories... Antitrust Division Notice Pursuant to the National Cooperative Research and Production Act of 1993--Joint Venture Agreement Between Cambridge Major Laboratories, Inc. and Konarka Technologies, Inc., in...

  1. Nuclear Physics Division progress report

    International Nuclear Information System (INIS)

    West, D.; Cookson, J.A.; Findlay, D.J.S.

    1984-06-01

    The 1983 progress report of the Nuclear Physics Division, UKAEA Harwell, is divided into four main topics. These are a) nuclear data and technology for nuclear power; b) nuclear studies; c) applications of nuclear and associated techniques, including ion beam techniques and moessbauer spectroscopy; and d) accelerator operation, maintenance and development. (U.K.)

  2. The Trouble with Long Division

    Science.gov (United States)

    Sellers, Patricia A.

    2010-01-01

    The fourth graders were ready to learn long division; however, their teachers were hesitant to begin the unit--just as they are every year. In a grade-level meeting with the school's math consultant, the teachers voiced their typical concerns. The math consultant was a university mathematics education professor spending a semester of sabbatical…

  3. Creating a Context for Learning: Activating Children’s Whole Number Knowledge Prepares Them to Understand Fraction Division

    Directory of Open Access Journals (Sweden)

    Pooja Gupta Sidney

    2017-07-01

    Full Text Available When children learn about fractions, their prior knowledge of whole numbers often interferes, resulting in a whole number bias. However, many fraction concepts are generalizations of analogous whole number concepts; for example, fraction division and whole number division share a similar conceptual structure. Drawing on past studies of analogical transfer, we hypothesize that children’s whole number division knowledge will support their understanding of fraction division when their relevant prior knowledge is activated immediately before engaging with fraction division. Children in 5th and 6th grade modeled fraction division with physical objects after modeling a series of addition, subtraction, multiplication, and division problems with whole number operands and fraction operands. In one condition, problems were blocked by operation, such that children modeled fraction problems immediately after analogous whole number problems (e.g., fraction division problems followed whole number division problems. In another condition, problems were blocked by number type, such that children modeled all four arithmetic operations with whole numbers in the first block, and then operations with fractions in the second block. Children who solved whole number division problems immediately before fraction division problems were significantly better at modeling the conceptual structure of fraction division than those who solved all of the fraction problems together. Thus, implicit analogies across shared concepts can affect children’s mathematical thinking. Moreover, specific analogies between whole number and fraction concepts can yield a positive, rather than a negative, whole number bias.

  4. Live birth potential of good morphology and vitrified blastocysts presenting abnormal cell divisions

    DEFF Research Database (Denmark)

    Azzarello, Antonino; Høst, Thomas; Hay-Schmidt, Anders

    2017-01-01

    division (ACD) from the 1st to the 4th cell cycle. ACDs were distinguished as failed cell divisions and multi-cell divisions. ACDs were recognized in 37.0% (no. 88/238) of good morphology blastocysts that were vitrified-warmed and transferred in our clinic. Good morphology blastocysts with ACDs showed...... a lower live birth rate (17.0%) than blastocyst with solely regular cell divisions (29.3%). ACDs could occur at more than one cell division in the same good morphology blastocyst. Reported as independent events, we observed ACDs occurring more frequently at the later cell cycles (1st: 1.3%; 2nd: 8.0%; 3rd......: 18.5%; 4th: 18.1%). More blastocysts presented failed cell divisions (no. 95) than multi-cell divisions (no. 14). Live births were achieved from blastocysts showing multi-cell divisions at any cell cycle and failed cell divisions from the 2nd cell cycle. Analyses of the subgroup of first blastocyst...

  5. Comparative studies on the effects of a yucca extract and acibenzolar-S-methyl (ASM) on inhibition of Venturia inaequalis in apple leaves

    DEFF Research Database (Denmark)

    Bengtsson, Marianne Vibeke; Wulff, Ednar Gadelha; Jørgensen, Hans Jørgen Lyngs

    2009-01-01

    and pathogen sporulation on leaves and both showed similar control efficacies as the reference treatment, sulphur. Whereas yucca extract and sulphur gave significant inhibition of conidial germination in vitro, ASM did not inhibit germination. Histopathological studies of the infection process of V. inaequalis...... in apple leaves showed that the yucca extract primarily acted by inhibiting pre-penetration events and penetration itself. In contrast, the ASM treatment significantly inhibited more stages of the infection process (pre-penetration, penetration and post-penetration events). These observations suggest...... was up-regulated following yucca treatment, to a level similar to that observed after treatment with ASM. The fungitoxic effect of sulphur on V. inaequalis was also confirmed in this study....

  6. Influência das variáveis biopsicossociais na qualidade de vida em asmáticos

    Directory of Open Access Journals (Sweden)

    Ana Paula Soares de Matos

    Full Text Available A asma brônquica é uma doença complexa e interfere com a qualidade de vida desses doentes. Pretendemos, com a presente investigação, estudar a relação das variáveis sócio-demográficas (género, idade e grau de instrução, clínicas (gravidade da doença, duração e tipo clínico e psicológicas (cognições, emoções e comportamentos com a qualidade de vida do doente asmático. Cinqüenta doentes asmáticos do Departamento de Pneumologia e Imunoalergologia dos Hospitais da Universidade de Coimbra preencheram cinco questionários de auto-resposta que avaliavam as variáveis psicológicas em estudo. Os dados clínicos relativamente à doença foram igualmente recolhidos.Os nossos resultados revelam-nos que a qualidade de vida se relaciona com um conjunto de variáveis que podemos denominar biopsicossociais (e.g., uma menor qualidade de vida relaciona-se com uma maior idade, menor escolaridade, uma atitude mais negativa face à asma, designada "estigma", cognições disfuncionais e comportamentos/emoções-problema relacionados com a asma. Implicações ao nível do tratamento são apresentadas.

  7. Intervención educativa para población infanto-juvenil asmática

    Directory of Open Access Journals (Sweden)

    Maria Antonia Acevedo Veja

    2015-11-01

    Full Text Available Se realizó una intervención educativa a la población infanto-juvenil asmática con edades entre ocho y once años en el policlínico de Manatí, Las Tunas, entre enero y julio de 2012, con el objetivo de evaluar la eficacia de la misma. La población de estudio estuvo formada por los 258 pacientes asmáticos de los 29 Consultorios de Médico de Familia (CMF del área, y la muestra por los 50 seleccionados por muestreo aleatorio simple. La información se obtuvo mediante un cuestionario que fue aplicado antes y después de la intervención educativa y los datos fueron recogidos durante la consulta y de la historia clínica individual. Se concluyó que predominó el sexo masculino, con antecedentes de primera línea de asma bronquial, con factores desencadenantes tales como: infecciones respiratorias agudas, polvo y humedad, así como aquellos que presentan signos clínicos de reflujo y que tienen una mala técnica de aplicación de spray. Se apreció un insuficiente nivel de conocimientos sobre la evaluación de severidad de la crisis, los factores desencadenantes, el manejo del spray y el tratamiento intercrisis, y las exacerbaciones.

  8. Non Destructive Test Dye Penetrant and Ultrasonic on Welding SMAW Butt Joint with Acceptance Criteria ASME Standard

    Science.gov (United States)

    Endramawan, T.; Sifa, A.

    2018-02-01

    The purpose of this research is to know the type of discontinuity of SMAW welding result and to determine acceptance criteria based on American Society of Mechanical Engineer (ASME) standard. Material used is mild steel 98,71% Fe and 0,212% C with hardness 230 VHN with specimen diameter 20 cm and thickness 1.2 cm which is welded use SMAW butt joint with electrode for rooting LB 52U diameter 2.6 mm, current 70 Ampere and voltage 380 volt, filler used LB 5218 electrode diameter 3.2 mm with current 80 Ampere and 380 volt. The method used to analyze the welded with non destructive test dye penetrant (PT) method to see indication on the surface of the object and Ultrasonic (UT) to see indication on the sub and inner the surface of the object, the result is discontinuity recorded and analyzed and then the discontinuity is determine acceptance criteria based on the American Society of Mechanical Engineer (ASME) standards. The result show the discontinuity of porosity on the surface of the welded and inclusion on sub material used ultrasonic test, all indication on dye penetrant or ultrasonic test if there were rejected of result of welded that there must be gouging on part which rejected and then re-welding.

  9. Health, Safety, and Environment Division

    Energy Technology Data Exchange (ETDEWEB)

    Wade, C [comp.

    1992-01-01

    The primary responsibility of the Health, Safety, and Environmental (HSE) Division at the Los Alamos National Laboratory is to provide comprehensive occupational health and safety programs, waste processing, and environmental protection. These activities are designed to protect the worker, the public, and the environment. Meeting these responsibilities requires expertise in many disciplines, including radiation protection, industrial hygiene, safety, occupational medicine, environmental science and engineering, analytical chemistry, epidemiology, and waste management. New and challenging health, safety, and environmental problems occasionally arise from the diverse research and development work of the Laboratory, and research programs in HSE Division often stem from these applied needs. These programs continue but are also extended, as needed, to study specific problems for the Department of Energy. The results of these programs help develop better practices in occupational health and safety, radiation protection, and environmental science.

  10. Ontario Hydro Research Division, 1980

    International Nuclear Information System (INIS)

    The work of the Research Division of Ontario Hydro provides technical and scientific support for the engineering and operation of a power system that includes hydraulic, fossil-fired, and nuclear generation. It also relates to the transmission and distribution of electricity and to the need to help customers use electricity with safety and economy. Among the examples of projects given are qualification of CANDU heat transport system components, pressure tube replacement, steam generator integrity, testing for earthquake resistance, and radioactive waste disposal

  11. Materials division facilities and equipment

    International Nuclear Information System (INIS)

    Biest, O. v.d.

    1984-01-01

    The research activities of the Division at the Petten Establishment have the aims of characterising the properties of high temperature materials in industrial process environments and of understanding the structures involved in order to gain an insight into behavioural mechanisms. Metallic materials fall within the scope of the programme; the activities are, at present, almost entirely concerned with austenitic steels and nickel based alloys. Starting in 1984, advanced ceramic materials will be studied as well. The equipment available permits the study of mechanical properties in controlled gaseous environments, of the rates and mechanisms of corrosive reactions between materials and those environments, and of the surface and bulk structures by advanced physical techniques. Special preparation and treatment techniques are available. The Division has developed a Data Bank on high temperature alloys. It also operates an information Centre, the activities of which include the organisation of scientific meetings, the commissioning of ''state of the art'' studies on topics in the field of high temperature materials and their applications and the development of a inventory of current research activities in the field in Europe. This booklet is intended to present the facilities and services of the Division to the organizations which are interested in its programmes of work

  12. Prokaryotic cell division: flexible and diverse

    NARCIS (Netherlands)

    den Blaauwen, T.

    2013-01-01

    Gram-negative rod-shaped bacteria have different approaches to position the cell division initiating Z-ring at the correct moment in their cell division cycle. The subsequent maturation into a functional division machine occurs in vastly different species in two steps with appreciable time in

  13. 7 CFR 29.16 - Division.

    Science.gov (United States)

    2010-01-01

    ... INSPECTION Regulations Definitions § 29.16 Division. Tobacco Division, Agricultural Marketing Service, U.S... 7 Agriculture 2 2010-01-01 2010-01-01 false Division. 29.16 Section 29.16 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing...

  14. Making Connections between Multiplication and Division

    Science.gov (United States)

    Downton, Ann

    2013-01-01

    This paper reports on 13 Grade 3 students' approaches to partitive and quotitive division word problems. Of particular interest was the extent to which students drew on their knowledge of multiplication to solve division problems. The findings suggest that developing a relationship between multiplication and division is more significant than…

  15. Division of household tasks and financial management

    NARCIS (Netherlands)

    Antonides, G.

    2011-01-01

    Both the standard economic model and bargaining theory make predictions about financial management and the division of household labor between household partners. Using a large Internet survey, we have tested several predictions about task divisions reported by Dutch household partners. The division

  16. 75 FR 16843 - Core Manufacturing, Multi-Plastics, Inc., Division, Sipco, Inc., Division, Including Leased...

    Science.gov (United States)

    2010-04-02

    ... Employment and Training Administration Core Manufacturing, Multi-Plastics, Inc., Division, Sipco, Inc..., 2009, applicable to workers of Core Manufacturing, Multi-Plastics, Inc., Division and Sipco, Inc... of Core Manufacturing, Multi-Plastics, Inc., Division and Sipco, Inc., Division, including leased...

  17. Strategic transfer pricing, absorption costing and vertical integration

    OpenAIRE

    Göx, Robert F

    1998-01-01

    This paper analyzes the use of transfer pricing as a strategic device in divisionalized firms facing duopolistic price competition. When transfer prices are observable, both firms' headquarters will exclude their marketing division from the external input market and charge a transfer price above the market price of the intermediate product to induce their marketing managers to behave as softer competitors on the final product market. When transfer prices are not observable, strategic transfer...

  18. Physics, Computer Science and Mathematics Division annual report, 1 January-31 December 1983

    International Nuclear Information System (INIS)

    Jackson, J.D.

    1984-08-01

    This report summarizes the research performed in the Physics, Computer Science and Mathematics Division of the Lawrence Berkeley Laboratory during calendar year 1983. The major activity of the Division is research in high-energy physics, both experimental and theoretical, and research and development in associated technologies. A smaller, but still significant, program is in computer science and applied mathematics. During 1983 there were approximately 160 people in the Division active in or supporting high-energy physics research, including about 40 graduate students. In computer science and mathematics, the total staff, including students and faculty, was roughly 50. Because of the creation in late 1983 of a Computing Division at LBL and the transfer of the Computer Science activities to the new Division, this annual report is the last from the Physics, Computer Science and Mathematics Division. In December 1983 the Division reverted to its historic name, the Physics Division. Its future annual reports will document high energy physics activities and also those of its Mathematics Department

  19. Physics, Computer Science and Mathematics Division annual report, 1 January-31 December 1983

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, J.D.

    1984-08-01

    This report summarizes the research performed in the Physics, Computer Science and Mathematics Division of the Lawrence Berkeley Laboratory during calendar year 1983. The major activity of the Division is research in high-energy physics, both experimental and theoretical, and research and development in associated technologies. A smaller, but still significant, program is in computer science and applied mathematics. During 1983 there were approximately 160 people in the Division active in or supporting high-energy physics research, including about 40 graduate students. In computer science and mathematics, the total staff, including students and faculty, was roughly 50. Because of the creation in late 1983 of a Computing Division at LBL and the transfer of the Computer Science activities to the new Division, this annual report is the last from the Physics, Computer Science and Mathematics Division. In December 1983 the Division reverted to its historic name, the Physics Division. Its future annual reports will document high energy physics activities and also those of its Mathematics Department.

  20. Division of labour in the yeast

    DEFF Research Database (Denmark)

    Wloch-Salamon, Dominika M.; Fisher, Roberta May; Regenberg, Birgitte

    2017-01-01

    Division of labour between different specialized cell types is a central part of how we describe complexity in multicellular organisms. However, it is increasingly being recognized that division of labour also plays an important role in the lives of predominantly unicellular organisms....... Saccharomyces cerevisiae displays several phenotypes that could be considered a division of labour, including quiescence, apoptosis and biofilm formation, but they have not been explicitly treated as such. We discuss each of these examples, using a definition of division of labour that involves phenotypic...... mechanisms and selective pressures that can lead to the evolution of the very first stages of a division of labour....

  1. Structural diversity in gallium(III) complexes of the tripodal triarsine MeC(CH2AsMe2)3.

    Science.gov (United States)

    Cheng, Fei; Hector, Andrew L; Levason, William; Reid, Gillian; Webster, Michael; Zhang, Wenjian

    2007-06-07

    The preparation and crystal structures of the first examples of gallium halide complexes with the tripodal arsine, MeC(CH(2)AsMe(2))3, reveal three distinctly different coordination modes for the ligand; the neutral [{micro(3)-MeC(CH(2)AsMe(2))3-kappaAs:kappaAs':kappaAs''}(GaI(3))3] with the triarsine coordinating to three GaI(3) units, [{Me(2)AsCH(2)C(Me)(CH(2)AsMe(2))2-kappa(2)AsAs'}GaCl(2)][GaCl(4)] involving bidentate chelation to a GaCl2+ cationic unit with the third As donor atom uncoordinated, and [{MeC(CH(2)AsMe(2))3-kappaAs:kappa(2)As'As''}(GaCl3)(GaCl2)][GaCl4] in which the triarsine forms a bidentate chelate to the GaCl2+ unit and the third As donor atom binds to a further GaCl3 unit.

  2. Dynamic experiments with high bisphenol-A concentrations modelled with an ASM model extended to include a separate XOC degrading microorganism

    DEFF Research Database (Denmark)

    Lindblom, Erik Ulfson; Press-Kristensen, Kåre; Vanrolleghem, P.A.

    2009-01-01

    with the endocrine disrupting XOC bisphenol-A (BPA) in an activated sludge process with real wastewater were used to hypothesize an ASM-based process model including aerobic growth of a specific BPA-degrading microorganism and sorption of BPA to sludge. A parameter estimation method was developed, which...

  3. Comportamiento de variables clínico-epidemiológicas en pacientes asmáticos. Consultorio Médico de Familia 14, Puerto Padre

    Directory of Open Access Journals (Sweden)

    José Ramón Martínez Pérez

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal en 40 pacientes asmáticos de todas las edades, pertenecientes al Consultorio 14 del área de salud de Puerto Padre, provincia de Las Tunas, durante los meses de enero a junio de 2008; con el objetivo de determinar el comportamiento de variables clínico-epidemiológicas en dichos pacientes. Para cumplimentar los objetivos se diseñó una encuesta que recogió las variables de interés. El análisis se hizo a través del sistema Statistix, permitiendo  obtener  la distribución de frecuencia y los porcientos. El test de Chi-Cuadrado se empleó en la comparación de variables cualitativas. Los resultados fueron descritos, interpretados y comparados con otros estudios. Se concluye que los pacientes grado I según Kraeppelin son los mas representados en nuestra población de pacientes asmáticos;  los broncodilatadores son los medicamentos mas utilizados por la población asmática estudiada; el incumplimiento del tratamiento medicamentoso no se relacionó con la severidad de la enfermedad en la población estudiada;  las malas condiciones de la vivienda y  el tabaquismo influyeron de forma negativa en la evolución del paciente asmático.

  4. Comparisons of ANS, ASME, AWS, and NFPA standards cited in the NRC standard review plan, NUREG-0800, and related documents

    Energy Technology Data Exchange (ETDEWEB)

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Spiesman, J.B. [Pacific Northwest Lab., Richland, WA (United States)

    1995-11-01

    This report provides the results of comparisons of the cited and latest versions of ANS, ASME, AWS and NFPA standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC`s Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review.

  5. Optimization of the Production of Sludge in an Activated Sludge System Through the Calibration of the ASM1 Model

    Directory of Open Access Journals (Sweden)

    Espinosa-Rodríguez M.A

    2015-01-01

    Full Text Available Recently several protocols have been proposed for the calibration the ASM1 model and each one of them emphasizes obtaining a good adjustment in the production of sludge. Precisely here is where the discrepancies are evaluated and adjustments made to data, through a mass balance. The objective of this work was to conduct first a balance of flows in the wastewater treatment plant "Dulces Nombres" in Monterrey, Nuevo Leon, Mexico, and then adjust them until closing properly the mass balance for the total phosphorus, total suspended solids, and inorganic suspended solids (ISS. On might say that to calibrate the biological model was important to determine reliably the flow of sludge (QWAS since on it depends the cell retention mean time (θC in the reactor; this was accomplished successfully through the balance of the ISS and using of GPS-X software for the simulation of scenarios of optimization.

  6. Comparisons of ANS, ASME, AWS, and NFPA standards cited in the NRC standard review plan, NUREG-0800, and related documents

    International Nuclear Information System (INIS)

    Ankrum, A.R.; Bohlander, K.L.; Gilbert, E.R.; Spiesman, J.B.

    1995-11-01

    This report provides the results of comparisons of the cited and latest versions of ANS, ASME, AWS and NFPA standards cited in the NRC Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants (NUREG 0800) and related documents. The comparisons were performed by Battelle Pacific Northwest Laboratories in support of the NRC's Standard Review Plan Update and Development Program. Significant changes to the standards, from the cited version to the latest version, are described and discussed in a tabular format for each standard. Recommendations for updating each citation in the Standard Review Plan are presented. Technical considerations and suggested changes are included for related regulatory documents (i.e., Regulatory Guides and the Code of Federal Regulations) citing the standard. The results and recommendations presented in this document have not been subjected to NRC staff review

  7. Aeração nasal em crianças asmáticas Nasal ventilation in asthmatics children

    Directory of Open Access Journals (Sweden)

    Daniele Andrade da Cunha

    2011-10-01

    Full Text Available OBJETIVO: identificar a presença de sinais de alterações na expiração de crianças asmáticas. MÉTODO: este estudo foi realizado com 30 crianças com idades entre 6 e 10 anos de ambos os sexos com diagnóstico clínico de asma confirmado pelo prontuário médico e 30 crianças não asmáticas também de ambos os sexos na mesma faixa etária. Foi avaliada a aeração nasal com o espelho milimetrado de Altmann, sendo mensurado o escape de ar nasal objetivando a verificação da saída uni ou bilateral do ar e a relação de simetria entre a narina direita e a esquerda. As imagens foram importadas para o computador por meio do scanner HP da série Scanjet 2400. A análise foi realizada no software Scion Image for Windows (Alpha 4.0.3.2. Para análise das variáveis quantitativas entre grupos foi aplicado o teste t-student e para a análise intragrupos foi aplicado o teste t-Student pareado.Todas as conclusões foram tomadas ao nível de significância de 5%, sendo usados o Excel 2000 e o SPSS v8.0, para as análises. RESULTADOS: não foram encontradas diferenças estatisticamente significantes entre as crianças asmáticas e não-ásmáticas, acerca das mensurações quanto à área total e quanto às áreas das narinas direita e esquerda. CONCLUSÃO: não foi identificada a presença de sinais de alterações na expiração de crianças asmáticas, desta forma, faz-se necessário um estudo mais específico das funções nasal e pulmonar.PURPOSE: to identify the symptoms of changes in the exhalation of asthmatic children. METHOD: this study was conducted with 30 children from 6 to 10 year-old, of both genders and with asthma clinical diagnosis confirmed by medical records and 30 non-asthmatic children from 6 to 10 year-old, of both genders, and with same age. We evaluated the nasal ventilation with Altmann millimeter nasal mirror measuring the nasal air escape in order to check their unilateral or bilateral air output and the relation of

  8. Pengaruh pH, Kecepatan Putar dan Asam Asetat terhadap Karakteristik CO2 Corrosion Baja ASME SA516 grade 70

    Directory of Open Access Journals (Sweden)

    Faris Adham

    2017-01-01

    Full Text Available Fenomena korosi merupakan sesuatu yang pasti terjadi pada setiap logam. Laju korosi dari suatu material dipengaruhi oleh beberapa faktor diantaranya yaitu nilai pH lingkungan dan karakteristik aliran fluida yang kontak langsung dengan logam. Pada oil and gas industry, baja ASME SA 516 grade 70 sering digunakan sebagai material flowline dan banyak terjadi CO2 Corrosion. Penelitian ini bertujuan untuk melakukan studi laju korosi material baja ASME SA 516 grade 70 yang mengandung CO2. Penelitian dilakukan dengan metoda weight loss menggunakan alat Rotating Cylinder Electrode (RCE selama 10 hari dan metode Polarization selama 1 jam. Selain itu digunakan pula XRD dan SEM guna mendukung data-data analisa. Pada penelitian ini digunakan media elektrolit NaCl 3,5% dengan kandungan CH3COOH sebesar 0 ppm dan 1500 ppm dengan variasi kecepatan putaran yaitu 0 RPM, 150 RPM, 300 RPM, dan 450 RPM pada pH 5 dan 6. Pada pengujian polarization, didapatkan hasil laju korosi tertinggi sebesar 9.9323 mm/y pada larutan CH3COOH 1500 ppm pH 5 dan kecepatan putar 450 RPM, sedangkan data dari pengujian weight loss sebesar 4.8795 mm/y. Hasil pengamatan SEM menunjukkan adanya perbedaan morfologi pada permukaan spesimen karena pengaruh kecepatan putaran. Kecepatan putaran mengakibatkan tergerusnya produk korosi oleh aliran. Pada pengujian XRD dengan menggunakan spesimen pH 5 dengan kandungan 0 ppm dan 1500 ppm 0 RPM ditemukan FeCO3, Fe(OH3 dan senyawa FeOOH sebagai produk korosi.

  9. On the fair division of greenhouse gas abatement cost

    Energy Technology Data Exchange (ETDEWEB)

    Boehringer, Christoph [University of Oldenburg, Department of Economics, Ammerlaender Heerstrasse 114-118, D-26111 Oldenburg (Germany); Centre for European Economic Research (ZEW), Mannheim (Germany); Helm, Carsten [Darmstadt University of Technology, Department of Law and Economics, Marktplatz 15, D-64283 Darmstadt (Germany)

    2008-05-15

    This paper introduces a solution for the fair division of emission reduction costs in the climate change regime. Our primary focus is on the fair division of efficiency gains that arise from exchanging the initial allocation of emission entitlements, rather than the initial allocation itself. We propose to complement the competitive Walrasian solution with welfare bounds, the ethical justification of which rests on commonality of ownership. Simulations with an intertemporal computable general equilibrium model illustrate the relevance of such welfare bounds. For a wide range of initial allocations of emission entitlements - including an equal per capita allocation - we find that developing countries should be fully compensated for their emission abatement efforts, but should not receive any further transfers. (author)

  10. Physics division annual report - 1999

    International Nuclear Information System (INIS)

    Thayer, K.

    2000-01-01

    This report summarizes the research performed in the past year in the Argonne Physics Division. The Division's programs include operation of ATLAS as a national heavy-ion user facility, nuclear structure and reaction research with beams of heavy ions, accelerator research and development especially in superconducting radio frequency technology, nuclear theory and medium energy nuclear physics. The Division took significant strides forward in its science and its initiatives for the future in the past year. Major progress was made in developing the concept and the technology for the future advanced facility of beams of short-lived nuclei, the Rare Isotope Accelerator. The scientific program capitalized on important instrumentation initiatives with key advances in nuclear science. In 1999, the nuclear science community adopted the Argonne concept for a multi-beam superconducting linear accelerator driver as the design of choice for the next major facility in the field a Rare Isotope Accelerator (RIA) as recommended by the Nuclear Science Advisory Committee's 1996 Long Range Plan. Argonne has made significant R and D progress on almost all aspects of the design concept including the fast gas catcher (to allow fast fragmentation beams to be stopped and reaccelerated) that in large part, defined the RIA concept the superconducting rf technology for the driver accelerator, the multiple-charge-state concept (to permit the facility to meet the design intensity goals with existing ion-source technology), and designs and tests of high-power target concepts to effectively deal with the full beam power of the driver linac. An NSAC subcommittee recommended the Argonne concept and set as tie design goal Uranium beams of 100-kwatt power at 400 MeV/u. Argonne demonstrated that this goal can be met with an innovative, but technically in-hand, design

  11. A decade of Radiometallurgy Division

    International Nuclear Information System (INIS)

    Ganguly, C.; Bahl, J.K.

    1988-12-01

    The main thrust of the Research and Development (R and D) activities of the Radiometallurgy Division of the Bhabha Atomic Research Centre is on (1) R and D work and production of plutonium bearing nuclear fuels, (2) Post-Irradiation Examination (PIE) of fuels and structural materials, and (3) failure analysis of power reactor components. The main activities and achievements of the Division during the decade beginning from April 1978 are highlighted and the new thrust areas oriented towards installing a series of 235 MWe and 500 MWe PHWR units and prototype fast breeder reactor (PFBR) of 500 MWe capacity during the next 15 years are described in brief. The major achievements during last ten years are: (1) development and irradiation testing of mixed uranium plutonium oxide (MOX), as an alternative fuel for boiling water reactors at Tarapur, (2) setting up of a 10 tons/year pilot plant for fabrication of oxide fuels and technical support for setting up such plants, (3) development and production of plutonium rich, advanced mixed uranium plutonium monocarbide driver fuel for the Fast Breeder Test Reactor comm issioned at Kalpakkam, (4) development and fabrication of Al- 233 U plate fuel elements for KAMINI reactor, (5) PIE of fuel elements from Indian reactors in operation, (6) failure analysis of reactor components, and (7) in-pile performance analysis of power reactor structural materials. A list of publications during 1978-88 by the scientists of the Division is given at the end. The publications are listed under the headings: (1) fuels, (2) non-destructive evaluation, (3) engineering development, (4) welding development, (5) characterization and property evaluation, and (6) post irradiation examination. The entire text is illustrated with a number of diagrams and photographs - many of them coloured . (M.G.B.)

  12. Heparan sulfate and cell division

    Directory of Open Access Journals (Sweden)

    Porcionatto M.A.

    1999-01-01

    Full Text Available Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic transformation. Several lines of experimental evidence suggest that heparan sulfate plays a role in cellular recognition, cellular adhesion and growth control. Heparan sulfate can participate in the process of cell division in two distinct ways, either as a positive or negative modulator of cellular proliferation, or as a response to a mitogenic stimulus.

  13. Progress report : Technical Physics Division

    International Nuclear Information System (INIS)

    Gopalaraman, C.P.; Deshpande, R.Y.

    1978-01-01

    The research and development work carried out in the Technical Physics Division of the Bhabha Atomic Research Centre, Bombay, is reported. Some of the achievements are: (1) fabrication of mass spectrometers for heavy water analysis and lithium 6/7 isotope ratio measurement, (2) fabrication of electronic components for mass spectrometers, (3) growing of sodium iodide crystals for radiation detectors, (4) development of sandwich detectors comprising of NaI(Tl) and CaI(Na), (5) fabrication of mass spectrometer type leak detectors and (6) fabrication of the high vacuum components of the vacuum system of the variable energy cyclotron based at Calcutta. (M.G.B.)

  14. Regulatory Safety Issues in the Structural Design Criteria of ASME Section III Subsection NH and for Very High Temperatures for VHTR and GEN IV

    International Nuclear Information System (INIS)

    O'Donnell, William J.; Griffin, Donald S.

    2007-01-01

    The objective of this task is to identify issues relevant to ASME Section III, Subsection NH [1], and related Code Cases that must be resolved for licensing purposes for VHTGRs (Very High Temperature Gas Reactor concepts such as those of PBMR, Areva, and GA); and to identify the material models, design criteria, and analysis methods that need to be added to the ASME Code to cover the unresolved safety issues. Subsection NH was originally developed to provide structural design criteria and limits for elevated-temperature design of Liquid Metal Fast Breeder Reactor (LMFBR) systems and some gas-cooled systems. The U.S. Nuclear Regulatory Commission (NRC) and its Advisory Committee for Reactor Safeguards (ACRS) reviewed the design limits and procedures in the process of reviewing the Clinch River Breeder Reactor (CRBR) for a construction permit in the late 1970s and early 1980s, and identified issues that needed resolution. In the years since then, the NRC and various contractors have evaluated the applicability of the ASME Code and Code Cases to high-temperature reactor designs such as the VHTGRs, and identified issues that need to be resolved to provide a regulatory basis for licensing. This Report describes: (1) NRC and ACRS safety concerns raised during the licensing process of CRBR , (2) how some of these issues are addressed by the current Subsection NH of the ASME Code; and (3) the material models, design criteria, and analysis methods that need to be added to the ASME Code and Code Cases to cover unresolved regulatory issues for very high temperature service.

  15. Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect.

    Science.gov (United States)

    Patel, Brijeshkumar S; Kugel, Michael J; Baehring, Gina; Ammit, Alaina J

    2017-08-01

    The xanthine doxofylline has been examined in clinical trials and shown to have efficacy and greater tolerability than theophylline in asthma and chronic obstructive pulmonary disease. The 'novofylline' doxofylline has demonstrated bronchodilatory and anti-inflammatory actions in in vivo and ex vivo experimental models of respiratory disease. However, there are limited studies in vitro. We address this herein and examine whether doxofylline has anti-inflammatory impact on primary cultures of airway smooth muscle (ASM) cells. We conduct a series of investigations comparing and contrasting doxofylline with the archetypal xanthine, theophylline, and the specific phosphodiesterase (PDE) 4 inhibitor, cilomilast. We confirm that the xanthine drugs do not have action as PDE inhibitors in ASM cells. Unlike cilomilast, doxofylline (and theophylline) do not increase cAMP production in ASM cells induced by long-acting β 2 -agonist formoterol. Similar to theophylline, and consistent with the lack of cAMP potentiation, doxofylline does not augment formoterol-induced upregulation of the anti-inflammatory protein mitogen-activated protein kinase phosphatase 1 (MKP-1). However, when we examine the effect of doxofylline on secretion of the interleukin 8 from ASM cells stimulated by tumour necrosis factor (an in vitro surrogate measure of inflammation), there was no repression of inflammation. This is in contrast to the anti-inflammatory impact exerted by theophylline and cilomilast in confirmatory experiments. In summary, our study is the first to examine the effect of doxofylline on ASM cells in vitro and highlights some distinct differences between two key members of xanthine drug family, doxofylline and theophylline. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Stochastic models for cell division

    Science.gov (United States)

    Stukalin, Evgeny; Sun, Sean

    2013-03-01

    The probability of cell division per unit time strongly depends of age of cells, i.e., time elapsed since their birth. The theory of cell populations in the age-time representation is systematically applied for modeling cell division for different spreads in generation times. We use stochastic simulations to address the same issue at the level of individual cells. Our approach unlike deterministic theory enables to analyze the size fluctuations of cell colonies at different growth conditions (in the absence and in the presence of cell death, for initially synchronized and asynchronous cell populations, for conditions of restricted growth). We find the simple quantitative relation between the asymptotic values of relative size fluctuations around mean values for initially synchronized cell populations under growth and the coefficients of variation of generation times. Effect of initial age distribution for asynchronous growth of cell cultures is also studied by simulations. The influence of constant cell death on fluctuations of sizes of cell populations is found to be essential even for small cell death rates, i.e., for realistic growth conditions. The stochastic model is generalized for biologically relevant case that involves both cell reproduction and cell differentiation.

  17. Chemical Technology Division annual technical report 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    The Chemical Technology (CMT) Division is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. The Division conducts research and development in three general areas: (1) development of advanced power sources for stationary and transportation applications and for consumer electronics, (2) management of high-level and low-level nuclear wastes and hazardous wastes, and (3) electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, and the chemistry of technology-relevant materials and electrified interfaces. In addition, the Division operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at Argonne National Laboratory (ANL) and other organizations. Technical highlights of the Division`s activities during 1997 are presented.

  18. Utilização de Ecolife® e Acibenzolar-s-metil (ASM no controle da antracnose da banana em pós-colheita Use of Ecolife® and Acibenzolar-S-metil (ASM on the control of antracnosis in banana post-harvest

    Directory of Open Access Journals (Sweden)

    Luciano Marinho Furtado

    2010-09-01

    Full Text Available O objetivo deste trabalho foi avaliar a ação dos produtos ASM e Ecolife no controle da antracnose pós-colheita em frutos de banana. Frutos sadios de banana, variedades maçã, prata, pacovan e cacau , em fase intermediária de maturação, foram imersos previamente em soluções de ASM e Ecolife e inoculados com Colletotrichum musae. Utilizou-se o delineamento inteiramente casualizado, em esquema fatorial com quatro repetições. Os resultados apresentados demonstraram a eficácia dos produtos nas concentrações de 5 ml/ L (Ecolife e 0,50g/ L (ASM no controle da antracnose nas variedades analisa das. A variedade cacau apresentou menor lesão quando tratada com o Ecolife (5,79 mm. Com relação ao efeito do ASM, a bana na prata demonstrou um melhor resultado, com tamanho médio de lesão de 5,62 mm. Com o decorrer do processo de maturação dos frutos houve um decréscimo na severidade da doença nas quatro variedades estudadas, exceto no tratamento testemunha, que continuou apresentando aumento no tamanho das lesões nos frutos e atingir a polpa ao final da maturação.The aim of this work was to evaluate the effects of ASM and Ecolife on the control of post-harvest antracnosis in banana. Banana fruits of Maçã, Prata, Pacovan and Figo varieties, at intermediate stage of maturation, were immersed in solutions of ASM and Ecolife and inoculated with Colletotrichum musae A completely randomized design was used, at a factorial scheme 4x2 (four varieties x two products with four replicates. The presented results demonstrated the susceptibility of the fruits to the disease, mainly Maça variety with lesion of 17,99 mm. It was demosntrated the effectiveness of products at concentrations of 5ml. L-1 (Ecolife and 0.50g. L-1 (ASM on antracnosis control. The Figo variety presented the smallest injuries when treated with Ecolife (5.79 mm. Regarding ASM effects, Prata variety demonstrated the best performance, with 5.62 mm of injuries diameter

  19. The 1988 Leti Division progress report

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    The 1988 progress report of the CEA's LETI Division (Division of Electronics, Technology and Instrumentation, France) is presented. The missions of LETI Division involve military and nuclear applications of electronics and fundamental research. The research programs developed in 1988 are the following: materials and components, non-volatile silicon memories, silicon-over-insulator, integrated circuits technologies, common experimental laboratory (opened to the European community), mass memories, photodetectors, micron sensors and flat screens [fr

  20. Chloroplast division checkpoint in eukaryotic algae

    Science.gov (United States)

    Sumiya, Nobuko; Fujiwara, Takayuki; Era, Atsuko; Miyagishima, Shin-ya

    2016-01-01

    Chloroplasts evolved from a cyanobacterial endosymbiont. It is believed that the synchronization of endosymbiotic and host cell division, as is commonly seen in existing algae, was a critical step in establishing the permanent organelle. Algal cells typically contain one or only a small number of chloroplasts that divide once per host cell cycle. This division is based partly on the S-phase–specific expression of nucleus-encoded proteins that constitute the chloroplast-division machinery. In this study, using the red alga Cyanidioschyzon merolae, we show that cell-cycle progression is arrested at the prophase when chloroplast division is blocked before the formation of the chloroplast-division machinery by the overexpression of Filamenting temperature-sensitive (Fts) Z2-1 (Fts72-1), but the cell cycle progresses when chloroplast division is blocked during division-site constriction by the overexpression of either FtsZ2-1 or a dominant-negative form of dynamin-related protein 5B (DRP5B). In the cells arrested in the prophase, the increase in the cyclin B level and the migration of cyclin-dependent kinase B (CDKB) were blocked. These results suggest that chloroplast division restricts host cell-cycle progression so that the cell cycle progresses to the metaphase only when chloroplast division has commenced. Thus, chloroplast division and host cell-cycle progression are synchronized by an interactive restriction that takes place between the nucleus and the chloroplast. In addition, we observed a similar pattern of cell-cycle arrest upon the blockage of chloroplast division in the glaucophyte alga Cyanophora paradoxa, raising the possibility that the chloroplast division checkpoint contributed to the establishment of the permanent organelle. PMID:27837024

  1. Genes involved in cell division in mycoplasmas

    OpenAIRE

    Alarcón, Frank; Vasconcelos, Ana Tereza Ribeiro de; Yim, Lucia; Zaha, Arnaldo

    2007-01-01

    Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important to compare their genomes to analyze putative genes involved in cell division processes. The division and cell wall (dcw) cluster, which ...

  2. Current programmes of Metallurgy Division (1991)

    International Nuclear Information System (INIS)

    1991-01-01

    Current research and development programmes of the Metallurgy Division are listed under the headings: 1)Thrust Areas, 2)High Temperature Materials Section, 3)Chemical Metallurgy Section, 4)Metallurgical Thermochemistry Section, 5)Physical Metallurgy Section, 6)Mechanical Metallurgy Section, 7)Corrosion Metallurgy Section, 8)Electrochemical Science and Technology Section, 9)Ceramics Section, and 10)Fabrication and Maintenance Group. A list of equipment in the Division and a list of sciientific personnel of the Division are also given. (M.G.B.)

  3. Physics division annual report 2005

    International Nuclear Information System (INIS)

    Glover, J.

    2007-01-01

    This report highlights the research performed in 2005 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory, medium energy nuclear research and accelerator research and development. The mission of Nuclear Physics is to understand the origin, evolution and structure of baryonic matter in the universe--the matter that makes up stars, planets and human life itself. The Division's research focuses on innovative new ways to address this mission and 2005 was a year of great progress. One of the most exciting developments is the initiation of the Californium Rare Ion Breeder Upgrade, CARIBU. By combining a Cf-252 fission source, the gas catcher technology developed for rare isotope beams, a high-resolution isobar separator, and charge breeding ECR technology, CARIBU will make hundreds of new neutron-rich isotope beams available for research. The cover illustration shows the anticipated intensities of low-energy beams that become available for low-energy experiments and for injection into ATLAS for reacceleration. CARIBU will be completed in early 2009 and provide us with considerable experience in many of the technologies developed for a future high intensity exotic beam facility. Notable results in research at ATLAS include a measurement of the isomeric states in 252 No that helps pin down the single particle structure expected for superheavy elements, and a new low-background measurement of 16 N beta-decay to determine the 12 C(α, γ) 16 O reaction rate that is so important in astrophysical environments. Precise mass measurements shed new light on the unitarity of the quark weak-mixing matrix in the search for physics beyond the standard model. ATLAS operated for 4686 hours of research in FY2005 while achieving 95% efficiency of beam delivery for experiments. In Medium-Energy Physics, radium isotopes were trapped in an atom trap for

  4. Physics division annual report 2005.

    Energy Technology Data Exchange (ETDEWEB)

    Glover, J.; Physics

    2007-03-12

    This report highlights the research performed in 2005 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory, medium energy nuclear research and accelerator research and development. The mission of Nuclear Physics is to understand the origin, evolution and structure of baryonic matter in the universe--the matter that makes up stars, planets and human life itself. The Division's research focuses on innovative new ways to address this mission and 2005 was a year of great progress. One of the most exciting developments is the initiation of the Californium Rare Ion Breeder Upgrade, CARIBU. By combining a Cf-252 fission source, the gas catcher technology developed for rare isotope beams, a high-resolution isobar separator, and charge breeding ECR technology, CARIBU will make hundreds of new neutron-rich isotope beams available for research. The cover illustration shows the anticipated intensities of low-energy beams that become available for low-energy experiments and for injection into ATLAS for reacceleration. CARIBU will be completed in early 2009 and provide us with considerable experience in many of the technologies developed for a future high intensity exotic beam facility. Notable results in research at ATLAS include a measurement of the isomeric states in {sup 252}No that helps pin down the single particle structure expected for superheavy elements, and a new low-background measurement of {sup 16}N beta-decay to determine the {sup 12}C({alpha},{gamma}){sup 16}O reaction rate that is so important in astrophysical environments. Precise mass measurements shed new light on the unitarity of the quark weak-mixing matrix in the search for physics beyond the standard model. ATLAS operated for 4686 hours of research in FY2005 while achieving 95% efficiency of beam delivery for experiments. In Medium-Energy Physics, radium

  5. Power Efficient Division and Square Root Unit

    DEFF Research Database (Denmark)

    Liu, Wei; Nannarelli, Alberto

    2012-01-01

    Although division and square root are not frequent operations, most processors implement them in hardware to not compromise the overall performance. Two classes of algorithms implement division or square root: digit-recurrence and multiplicative (e.g., Newton-Raphson) algorithms. Previous work...... shows that division and square root units based on the digit-recurrence algorithm offer the best tradeoff delay-area-power. Moreover, the two operations can be combined in a single unit. Here, we present a radix-16 combined division and square root unit obtained by overlapping two radix-4 stages...

  6. Negotiating transfer pricing using the Nash bargaining solution

    Directory of Open Access Journals (Sweden)

    Clempner Julio B.

    2017-12-01

    Full Text Available This paper analyzes and proposes a solution to the transfer pricing problem from the point of view of the Nash bargaining game theory approach. We consider a firm consisting of several divisions with sequential transfers, in which central management provides a transfer price decision that enables maximization of operating profits. Price transferring between divisions is negotiable throughout the bargaining approach. Initially, we consider a disagreement point (status quo between the divisions of the firm, which plays the role of a deterrent. We propose a framework and a method based on the Nash equilibrium approach for computing the disagreement point. Then, we introduce a bargaining solution, which is a single-valued function that selects an outcome from the feasible pay-offs for each bargaining problem that is a result of cooperation of the divisions of the firm involved in the transfer pricing problem. The agreement reached by the divisions in the game is the most preferred alternative within the set of feasible outcomes, which produces a profit-maximizing allocation of the transfer price between divisions. For computing the bargaining solution, we propose an optimization method. An example illustrating the usefulness of the method is presented.

  7. An activated sludge modeling framework for xenobiotic trace chemicals (ASM-X): assessment of diclofenac and carbamazepine.

    Science.gov (United States)

    Plósz, Benedek Gy; Langford, Katherine H; Thomas, Kevin V

    2012-11-01

    Conventional models for predicting the fate of xenobiotic organic trace chemicals, identified, and calibrated using data obtained in batch experiments spiked with reference substances, can be limited in predicting xenobiotic removal in wastewater treatment plants (WWTPs). At stake is the level of model complexity required to adequately describe a general theory of xenobiotic removal in WWTPs. In this article, we assess the factors that influence the removal of diclofenac and carbamazepine in activated sludge, and evaluate the complexity required for the model to effectively predict their removal. The results are generalized to previously published cases. Batch experimental results, obtained under anoxic and aerobic conditions, were used to identify extensions to, and to estimate parameter values of the activated sludge modeling framework for Xenobiotic trace chemicals (ASM-X). Measurement and simulation results obtained in the batch experiments, spiked with the diclofenac and carbamazepine content of preclarified municipal wastewater shows comparably high biotransformation rates in the presence of growth substrates. Forward dynamic simulations were performed using full-scale data obtained from Bekkelaget WWTP (Oslo, Norway) to evaluate the model and to estimate the level of re-transformable xenobiotics present in the influent. The results obtained in this study demonstrate that xenobiotic loading conditions can significantly influence the removal capacity of WWTPs. We show that the trace chemical retransformation in upstream sewer pipes can introduce considerable error in assessing the removal efficiency of a WWTP, based only on parent compound concentration measurements. The combination of our data with those from the literature shows that solids retention time (SRT) can enhance the biotransformation of diclofenac, which was not the case for carbamazepine. Model approximation of the xenobiotic concentration, detected in the solid phase, suggest that between

  8. Rehabilitación integral y tolerancia al ejercicio físico en escolares asmáticos severos

    Directory of Open Access Journals (Sweden)

    . Héctor Alejandro Cruz Oliver

    1995-04-01

    Full Text Available Se realizó un estudio en 99 escolares asmáticos severos, incluidos en un programa de rehabilitación integral en el centro para niños asmáticos de la Ciudad de los Pioneros "José Martí" en Tarará, durante el curso escolar 1991-1992. A todos los escolares se les sometió antes de comenzar el programa, a una prueba de tolerancia al ejercicio físico mediante la carrera libre, y acorde con los resultados de ésta se clasificaron en 2 grupos; grupo I, con asma inducida por el ejercicio (AIE y grupo II, sin AIE. Al finalizar el programa de rehabilitación al grupo I se le sometió nuevamente a la prueba de tolerancia al ejercicio físico. Todos los escolares se evaluaron mediante la espirometría en condiciones basales antes del programa de rehabilitación y al finalizar éste. En 55 escolares (55,5 % se constató la presencia inicial de AIE. Al finalizar el programa de rehabilitación sólo en 23 de ellos se mantuvo este fenómeno. Con excepción de un escolar perteneciente al grupo I el resto de los niños toleraron sin dificultad las actividades físicas programadas. En relación con los parámetros de función respiratoria no se hallaron diferencias significativas en ninguno de ellos, cuando se compararon ambos grupos entre sí antes del programa de rehabilitación, y después de él. Comparando cada grupo consigo mismo sólo se observó un incremento significativo del flujo máximo medio (MMF en ambos grupos, lo que reflejó una disminución del componente obstructivo bronquial periférico.

  9. Investigation of the Stress Intensity Limits of ASME Section III Div.5 for Structure Design Criteria of SFR Fuel Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Jin-Yup; Kim, Hyung-Kyu; Cheon, Jin-Sik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    These affect the mechanical design of the fuel assembly components. And thus, appropriate structural design criteria should also be chosen to incorporate the specific design conditions of the SFR fuel assemblies. Among them, the temperature is one of the most crucial conditions to be concerned because the sodium coolant temperature is normally more than 500ºC which is much higher than that of the LWR (< 350ºC). This implies that a thermal creep should be significantly considered in the SFR fuel assembly mechanical design. In addition to the high temperature condition, an irradiation swelling is also an important behavior that the SFR fuel assembly material should accommodate. To incorporate the temperature and irradiation impacts, the material of the fuel assembly components is presently determined to be made of HT-9, the ferriticmartensitic steel. In this paper, the ASME Sec. III Div. 5 (referred to as ‘Div. 5’ hereinafter), which was developed for a ‘high temperature reactor’, is considered as one of the structural design criteria for the mechanical design of SFR fuel assemblies. In this paper, the stress intensity limits, S{sub m} and S{sub t} of HT-9 were built for the structural criteria of an SFR fuel assembly. S{sub m} is obtained from the ultimate strength. As for S{sub t}, it is more complicated because of its dependency of time duration in addition to temperature. Following the definition of S{sub mt}, the method in the ASME Sec. III Div. 1, Subsec. NH was consulted. We found that the Sm is adopted as S{sub mt} under the temperature about 470ºC which is relatively low temperature range and over 470ºC with relatively short time duration as 1000 hours. And the S{sub t} is adopted as Smt at over 470ºC and long time duration over 34800 hours, and over 520ºC and 10{sup 4} hours too. And at over 570ºC and 1000 hours, and at over 630ºC and 100 hours, S{sub t} is also adopted for S{sub mt}.

  10. Moral Reasoning of Division III and Division I Athletes: Is There a Difference?

    Science.gov (United States)

    Stoll, Sharon Kay; And Others

    This study sought to examine the potentially corrupting influences of media attention, money, and the accompanying stress on the moral reasoning of student athletes at both Division I and Division III National College Athletics Association (NCAA) schools. Subjects were 718 nonathletes and 277 randomly selected athletes at a Division I school and…

  11. Deepening Students' Understanding of Multiplication and Division by Exploring Divisibility by Nine

    Science.gov (United States)

    Young-Loveridge, Jenny; Mills, Judith

    2012-01-01

    This article explores how a focus on understanding divisibility rules can be used to help deepen students' understanding of multiplication and division with whole numbers. It is based on research with seven Year 7-8 teachers who were observed teaching a group of students a rule for divisibility by nine. As part of the lesson, students were shown a…

  12. Physics Division annual report 2004.

    Energy Technology Data Exchange (ETDEWEB)

    Glover, J.

    2006-04-06

    This report highlights the research performed in 2004 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory, medium energy nuclear research and accelerator research and development. The intellectual challenges of this research represent some of the most fundamental challenges in modern science, shaping our understanding of both tiny objects at the center of the atom and some of the largest structures in the universe. A great strength of these efforts is the critical interplay of theory and experiment. Notable results in research at ATLAS include a measurement of the charge radius of He-6 in an atom trap and its explanation in ab-initio calculations of nuclear structure. Precise mass measurements on critical waiting point nuclei in the rapid-proton-capture process set the time scale for this important path in nucleosynthesis. An abrupt fall-off was identified in the subbarrier fusion of several heavy-ion systems. ATLAS operated for 5559 hours of research in FY2004 while achieving 96% efficiency of beam delivery for experiments. In Medium Energy Physics, substantial progress was made on a long-term experiment to search for the violation of time-reversal invariance using trapped Ra atoms. New results from HERMES reveal the influence of quark angular momentum. Experiments at JLAB search for evidence of color transparency in rho-meson production and study the EMC effect in helium isotopes. New theoretical results include a Poincare covariant description of baryons as composites of confined quarks and non-point-like diquarks. Green's function Monte Carlo techniques give accurate descriptions of the excited states of light nuclei and these techniques been extended to scattering states for astrophysics studies. A theoretical description of the phenomena of proton radioactivity has been extended to triaxial nuclei. Argonne

  13. News from the Library: A new key reference work for the engineer: ASME's Boiler and Pressure Vessel Code at the CERN Library

    CERN Multimedia

    CERN Library

    2011-01-01

    The Library is aiming at offering a range of constantly updated reference books, to cover all areas of CERN activity. A recent addition to our collections strengthens our offer in the Engineering field.   The CERN Library now holds a copy of the complete ASME Boiler and Pressure Vessel Code, 2010 edition. This code establishes rules of safety governing the design, fabrication, and inspection of boilers and pressure vessels, and nuclear power plant components during construction. This document is considered worldwide as a reference for mechanical design and is therefore important for the CERN community. The Code published by ASME (American Society of Mechanical Engineers) is kept current by the Boiler and Pressure Committee, a volunteer group of more than 950 engineers worldwide. The Committee meets regularly to consider requests for interpretations, revision, and to develop new rules. The CERN Library receives updates and includes them in the volumes until the next edition, which is expected to ...

  14. Radioactive Waste and Clean-up Division

    International Nuclear Information System (INIS)

    Collard, G.

    2001-01-01

    The main objectives of the Radioactive Waste and Clean-up division of SCK-CEN are outlined. The division's programme consists of research, development and demonstration projects and aims to contribute to the objectives of Agenda 21 on sustainable development in the field of radioactive waste and rehabilitation of radioactively contaminated sites

  15. Hemispheric Division of Labour in Reading

    Science.gov (United States)

    Shillcock, Richard C.; McDonald, Scott A.

    2005-01-01

    We argue that the reading of words and text is fundamentally conditioned by the splitting of the fovea and the hemispheric division of the brain, and, furthermore, that the equitable division of labour between the hemispheres is a characteristic of normal visual word recognition. We report analyses of a representative corpus of the eye fixations…

  16. Materials Sciences Division 1990 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-31

    This report is the Materials Sciences Division`s annual report. It contains abstracts describing materials research at the National Center for Electron Microscopy, and for research groups in metallurgy, solid-state physics, materials chemistry, electrochemical energy storage, electronic materials, surface science and catalysis, ceramic science, high tc superconductivity, polymers, composites, and high performance metals.

  17. Radiochemistry Division annual progress report : 1992

    International Nuclear Information System (INIS)

    Natarajan, V.; Godbole, S.V.; Iyer, R.H.

    1994-01-01

    The research and development activities of the Radiochemistry Division during 1992 are briefly described in the form of individual summaries grouped under the headings: 1) Nuclear Chemistry, 2) Actinide Chemistry, 3) Spectroscopy, and 4) Instrumentation. A list of publications numbering 95 by the scientific staff of the Division is also included in the report. (author). 35 figs., 56 tabs

  18. Medical Sciences Division report for 1993

    International Nuclear Information System (INIS)

    1993-01-01

    This year's Medical Sciences Division (MSD) Report is organized to show how programs in our division contribute to the core competencies of Oak Ridge Institute for Science and Education (ORISE). ORISE's core competencies in education and training, environmental and safety evaluation and analysis, occupational and environmental health, and enabling research support the overall mission of the US Department of Energy (DOE)

  19. Polarized Cell Division of Chlamydia trachomatis.

    Directory of Open Access Journals (Sweden)

    Yasser Abdelrahman

    2016-08-01

    Full Text Available Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections and trachoma, lacks FtsZ, it has been assumed to divide by binary fission. We show here that Chlamydia divides by a polarized cell division process similar to the budding process of a subset of the Planctomycetes that also lack FtsZ. Prior to cell division, the major outer-membrane protein of Chlamydia is restricted to one pole of the cell, and the nascent daughter cell emerges from this pole by an asymmetric expansion of the membrane. Components of the chlamydial cell division machinery accumulate at the site of polar growth prior to the initiation of asymmetric membrane expansion and inhibitors that disrupt the polarity of C. trachomatis prevent cell division. The polarized cell division of C. trachomatis is the result of the unipolar growth and FtsZ-independent fission of this coccoid organism. This mechanism of cell division has not been documented in other human bacterial pathogens suggesting the potential for developing Chlamydia-specific therapeutic treatments.

  20. On Durkheim's Explanation of Division of Labor.

    Science.gov (United States)

    Rueschemeyer, Dietrich

    1982-01-01

    In De la Division du Travail Social, Durkheim's causal explanation for secular increases in the division of labor and the differentiation of social structure is flawed. His metatheoretical concerns expressed in the critique of utilitarian social theory flawed his contributions to a causal explanation of social differentiation. (Author/AM)

  1. Division Unit for Binary Integer Decimals

    DEFF Research Database (Denmark)

    Lang, Tomas; Nannarelli, Alberto

    2009-01-01

    In this work, we present a radix-10 division unit that is based on the digit-recurrence algorithm and implements binary encodings (binary integer decimal or BID) for significands. Recent decimal division designs are all based on the binary coded decimal (BCD) encoding. We adapt the radix-10 digit...

  2. "American Gothic" and the Division of Labor.

    Science.gov (United States)

    Saunders, Robert J.

    1987-01-01

    Provides historical review of gender-based division of labor. Argues that gender-based division of labor served a purpose in survival of tribal communities but has lost meaning today and may be a handicap to full use of human talent and ability in the arts. There is nothing in various art forms which make them more appropriate for males or…

  3. instU_3d_asm_Cp: MERRA 3D IAU State, Meteorology Diurnal 1.25 x 1.25 degree V5.2.0 (MAIUCPASM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAIUCPASM or instU_3d_asm_Cp data product is the MERRA Data Assimilation System 3-Dimensional assimilated state on pressure, at a reduced resolution. It is a...

  4. inst3_3d_asm_Cp: MERRA 3D IAU State, Meteorology Instantaneous 3-hourly 1.25 x 1.25 degree V5.2.0 (MAI3CPASM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAI3CPASM or inst3_3d_asm_Cp data product is the MERRA Data Assimilation System 3-Dimensional assimilated state on pressure, at a reduced resolution. It is a...

  5. instM_3d_asm_Cp: MERRA 3D IAU State, Meteorology Monthly Mean 1.25 x 1.25 degree V5.2.0 (MAIMCPASM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAIMCPASM or instM_3d_asm_Cp data product is the MERRA Data Assimilation System 3-Dimensional assimilated state on pressure, at a reduced resolution. It is a...

  6. 9 July 2012 - Academy of Sciences Malaysia (ASM), Chairman, Mathematical and Physical Sciences Discipline Group M. Yahaya FASc and his delegation visiting the LHC superconducting magnet test hall with Technology Department G. De Rijk.

    CERN Document Server

    Maximilien Brice

    2012-01-01

    9 July 2012 - Academy of Sciences Malaysia (ASM), Chairman, Mathematical and Physical Sciences Discipline Group M. Yahaya FASc and his delegation visiting the LHC superconducting magnet test hall with Technology Department G. De Rijk.

  7. const_2d_asm_Nx: MERRA DAS 2d constants 0.667 x 0.5 degree V5.2.0 (MAC0NXASM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAC0NXASM or const_2d_asm_Nx data product is the MERRA Data Assimilation System 2-Dimensional Constants at native resolution. MERRA, or the Modern Era...

  8. Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A.

    Science.gov (United States)

    Kaur, Manminder; Holden, Neil S; Wilson, Sylvia M; Sukkar, Maria B; Chung, Kian Fan; Barnes, Peter J; Newton, Robert; Giembycz, Mark A

    2008-09-01

    In diseases such as asthma, airway smooth muscle (ASM) cells play a synthetic role by secreting inflammatory mediators such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, or IL-8 and by expressing surface adhesion molecules, including ICAM-1. In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells. IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective. In each case, repression of these inflammatory indexes was prevented by adenoviral overexpression of PKIalpha, a highly selective PKA inhibitor. These data indicate a PKA-dependent mechanism of repression and suggest that agents that elevate intracellular cAMP, and thereby activate PKA, may have a widespread anti-inflammatory effect in ASM cells. Since ICAM-1 and GM-CSF are highly NF-kappaB-dependent genes, we used an adenoviral-delivered NF-kappaB-dependent luciferase reporter to examine the effects of forskolin and the beta(2)-adrenoceptor agonists on NF-kappaB activation. There was no effect on luciferase activity measured in the presence of forskolin or beta(2)-adrenoceptor agonists. This finding is consistent with the observation that IL-1beta-induced expression of IL-6, a known NF-kappaB-dependent gene in ASM, was also unaffected by beta(2)-adrenoceptor agonists, forskolin, PGE(2), 8-bromo-cAMP, or rolipram. Collectively, these results indicate that repression of IL-1beta-induced ICAM-1 expression and GM-CSF release by cAMP-elevating agents, including beta(2)-adrenoceptor agonists, may not occur through a generic effect on NF-kappaB.

  9. Molecular coordination of Staphylococcus aureus cell division

    Science.gov (United States)

    Cotterell, Bryony E; Walther, Christa G; Fenn, Samuel J; Grein, Fabian; Wollman, Adam JM; Leake, Mark C; Olivier, Nicolas; Cadby, Ashley; Mesnage, Stéphane; Jones, Simon

    2018-01-01

    The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. PMID:29465397

  10. Chemical Technology Division annual technical report 1997

    International Nuclear Information System (INIS)

    1998-06-01

    The Chemical Technology (CMT) Division is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. The Division conducts research and development in three general areas: (1) development of advanced power sources for stationary and transportation applications and for consumer electronics, (2) management of high-level and low-level nuclear wastes and hazardous wastes, and (3) electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, and the chemistry of technology-relevant materials and electrified interfaces. In addition, the Division operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at Argonne National Laboratory (ANL) and other organizations. Technical highlights of the Division's activities during 1997 are presented

  11. 1998 Chemical Technology Division Annual Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Ackerman, J.P.; Einziger, R.E.; Gay, E.C.; Green, D.W.; Miller, J.F.

    1999-08-06

    The Chemical Technology (CMT) Division is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. The Division conducts research and development in three general areas: (1) development of advanced power sources for stationary and transportation applications and for consumer electronics, (2) management of high-level and low-level nuclear wastes and hazardous wastes, and (3) electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, and the chemistry of technology-relevant materials. In addition, the Division operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at Argonne National Laboratory (ANL) and other organizations. Technical highlights of the Division's activities during 1998 are presented.

  12. Granulomatose broncocêntrica idiopática em jovem não asmática

    Directory of Open Access Journals (Sweden)

    Santos José Wellington Alves dos

    2003-01-01

    Full Text Available Granulomatose broncocêntrica é um achado histopatológico descritivo, caracterizado pela inflamação granulomatosa necrosante, centrada em brônquios e bronquíolos, e que ocorre associada a doenças infecciosas, imunológicas e neoplásicas, ou de forma idiopática. Este trabalho relata o caso de uma jovem não asmática de 26 anos com dor torácica, febre e tosse produtiva havia um mês, que apresentou consolidação e cavitação em segmento lingular, observadas na radiografia e na tomografia computadorizada de tórax. Punção aspirativa transbrônquica evidenciou lesão inflamatória inespecífica, sem etiologia identificada. O exame histológico de material obtido por biópsia pulmonar a céu aberto foi compatível com granulomatose broncocêntrica idiopática. Após tratamento com prednisona, houve melhora clínica, sem recidivas.

  13. CEASEMT system: the TEDEL code. Pipings - Plasticity - Dynamics - Statics - Buckling - Thermoplasticity - Creep - Large displacements - FLUIDS - SEISMS - ASME

    International Nuclear Information System (INIS)

    Hoffmann, Alain; Jeanpierre, Francoise; Axisa, Francois; Chevalier, Gerard; Lepareux, Michel.

    1977-01-01

    The TEDEL code is intended for elastic and plastic computation of three-dimensional pipes and frames with possible junction to shells. The structures are described with using assemblies of beam elements, or piping elements such as, curved pipes, 90 0 elbows, tees, any elements, the stiffness properties of which are given to TEDEL. TEDEL allows the dynamic computation of the structures: search of eigenfrequencies and eigenmodes of vibration, time response to any time-dependent canvassing. This response can be obtained either from recombining a number of eigenmodes, or from a direct numerical integration of the dynamics equation. In these last two cases TEDEL accounts for some possible damping. A TEDEL option allows critical buckling loads to be computed (Euler). The structures can offer any shapes comprising any number of materials. The data are readout without any format, and distributed in optional commands with a precise physical meaning: GEOMETRY, MATERIALS, LOAD, COMPUTATION, END. A dynamical memory control allows the size of the routine to be adapted to the problem to be treated. For pipings, an option is intended for an automatic checking of the stress level with regard to the limiting values of the ASME. Geometrical data, node positions, element numbering are given by COCO which also delivers perspective drawings for the structure to be studied. The results on magnetic tapes can be treated by the subroutines ESPACE-VISU-TEMPS [fr

  14. More on fatigue verification of Class 1 nuclear power piping according to ASME BPV III NB-3600

    International Nuclear Information System (INIS)

    Zeng, Lingfu; Dahlström, Lars; Jansson, Lennart G.

    2011-01-01

    In this paper, fatigue verification of Class 1 nuclear power piping according to ASME Boiler and Pressure Vessel Code, Section III, NB-3600, and relevant issues that are often discussed in connection to the power uprate of several Swedish BWR reactors in recent years, are dealt with. Key parameters involved in the fatigue verification, i.e. the alternating stress intensity S alt , the penalty factor K e and the cumulative damage factor U, and relevant computational procedures applicable for the assessment of low-cycle fatigue failure using strain-controlled data, are particularly addressed. A so-called simplified elastic-plastic discontinuity analysis for alternative verification when basic fatigue requirements found unsatisfactory, and the procedures provided in NB-3600 for evaluating the alternating stress intensity S alt , are reviewed in detail. Our emphasis is placed on other procedures alternative to the simplified elastic-plastic discontinuity analysis. A more in-depth discussion is given to an alternative suggested earlier by the authors using nonlinear finite element analyses. This paper is a continuation of our work presented in ICONE16/17/18, which attempted to categorize design rules in the code into linear design rules and non-linear design rules and to clarify corresponding design requirements and finite element analyses, in particular, those non-linear ones. (author)

  15. Optimization of A(2)O BNR processes using ASM and EAWAG Bio-P models: model performance.

    Science.gov (United States)

    El Shorbagy, Walid E; Radif, Nawras N; Droste, Ronald L

    2013-12-01

    This paper presents the performance of an optimization model for a biological nutrient removal (BNR) system using the anaerobic-anoxic-oxic (A(2)O) process. The formulated model simulates removal of organics, nitrogen, and phosphorus using a reduced International Water Association (IWA) Activated Sludge Model #3 (ASM3) model and a Swiss Federal Institute for Environmental Science and Technology (EAWAG) Bio-P module. Optimal sizing is attained considering capital and operational costs. Process performance is evaluated against the effect of influent conditions, effluent limits, and selected parameters of various optimal solutions with the following results: an increase of influent temperature from 10 degrees C to 25 degrees C decreases the annual cost by about 8.5%, an increase of influent flow from 500 to 2500 m(3)/h triples the annual cost, the A(2)O BNR system is more sensitive to variations in influent ammonia than phosphorus concentration and the maximum growth rate of autotrophic biomass was the most sensitive kinetic parameter in the optimization model.

  16. Modeling nitrous oxide production during biological nitrogen removal via nitrification and denitrification: extensions to the general ASM models.

    Science.gov (United States)

    Ni, Bing-Jie; Ruscalleda, Maël; Pellicer-Nàcher, Carles; Smets, Barth F

    2011-09-15

    Nitrous oxide (N(2)O) can be formed during biological nitrogen (N) removal processes. In this work, a mathematical model is developed that describes N(2)O production and consumption during activated sludge nitrification and denitrification. The well-known ASM process models are extended to capture N(2)O dynamics during both nitrification and denitrification in biological N removal. Six additional processes and three additional reactants, all involved in known biochemical reactions, have been added. The validity and applicability of the model is demonstrated by comparing simulations with experimental data on N(2)O production from four different mixed culture nitrification and denitrification reactor study reports. Modeling results confirm that hydroxylamine oxidation by ammonium oxidizers (AOB) occurs 10 times slower when NO(2)(-) participates as final electron acceptor compared to the oxic pathway. Among the four denitrification steps, the last one (N(2)O reduction to N(2)) seems to be inhibited first when O(2) is present. Overall, N(2)O production can account for 0.1-25% of the consumed N in different nitrification and denitrification systems, which can be well simulated by the proposed model. In conclusion, we provide a modeling structure, which adequately captures N(2)O dynamics in autotrophic nitrification and heterotrophic denitrification driven biological N removal processes and which can form the basis for ongoing refinements.

  17. A Retrospective Look at 20 Years of ASM Education Programs (1990-2010) and a Prospective Look at the Next 20 Years (2011-2030).

    Science.gov (United States)

    Chang, Amy

    2011-01-01

    Professional societies provide visibility and legitimacy to the work of their post secondary educator members, advocate best practices in courses and sponsored student research, and establish deep networks and communities that catalyze members to collectively engage in undergraduate teaching and learning scholarship. Within the American Society for Microbiology (ASM), the Education Board, established in the mid-1970s, assumes this role. I have been fortunate enough to watch several pivotal programs support our growth and change the status quo by providing opportunities for biology educators to flourish. In this retrospective review, the background and details I offer about each initiative help explain ASM Education offerings, how our growth has been supported and how the status quo has changed. In this prospective look, I offer my vision of the future in post secondary education where classroom learning is student-centered and focused on global problems affecting our health and environment. For the profession to proliferate, the ASM must provide members as many opportunities in learning biology as they do with advancing biology to new frontiers.

  18. DFT study of isomers of the ruthenium dihydride complex RuH2(CO)2(AsMe2Ph)2.

    Science.gov (United States)

    Said, R Ben; Essalah, K; Sanhoury, M A K; Hussein, K; Boughdiri, S; Chermette, H

    2017-04-01

    A density functional theory (DFT) study of cct-As, ccc, and cct-CO isomers of the ruthenium dihydride complex RuH 2 (CO) 2 (AsMe 2 Ph) 2 is reported (see Scheme for the labeling isomer 34 structures of RuH 2 (CO) 2 (AsMe 2 Ph) 2 ). Complex geometries and relative energies of different isomers have been calculated with both B3LYP and M06-2X functionals. The results show that the B3LYP calculated Boltzmann populations of cct-As, ccc, and cct-CO isomers are 65.5, 34.2, and 0.3%, respectively. These are in better agreement with the experimental data than those calculated at the M06-2X level. However, the calculations of 1 H NMR chemical shifts were found to be better described with M06-2X than with B3LYP or with HF level of theories. In addition, a transition state between the two most stable isomers was determined through DFT/(B3LYP or M06-2X) calculations. Graphical Abstract Scheme: Labeling structure of RuH 2 (CO) 2 (AsMe 2 Ph) 2 .

  19. EDH 'Millionaire' in PS Division

    CERN Document Server

    2001-01-01

    Christmas cheer! Left to right: Gerard Lobeau receives a bottle of Champagne from Derek Mathieson and Jurgen De Jonghe in recognition of EDH's millionth document. At 14:33 on Monday 3 December a technician in PS division, Gerard Lobeau, unwittingly became part of an important event in the life of CERN's Electronic Document Handling system (EDH). While ordering some pieces of aluminum for one of the PS's 10Mhz RF cavities, he created EDH document number 1,000,000. To celebrate the event Derek Mathieson (EDH Project Leader) and Jurgen De Jonghe (Original EDH Project Leader) presented Mr Lobeau with a bottle of champagne. As with 93% of material requests, Mr Lobeau's order was delivered within 24 hours. 'I usually never win anything' said Mr Lobeau as he accepted his prize, 'I initially though there may have been a problem with EDH when the document number had so many zeros in it, and was then surprised to get a phone call from you a few minutes later.' The EDH team had been monitoring the EDH document number ...

  20. Division of Information Technology - Overview

    International Nuclear Information System (INIS)

    Szlachciak, J.

    2008-01-01

    Full text: The Division of Information Technology continued its service-oriented activities in 2007. Our main duty was a day-to-day support to all units in the Institute in IT related matters. One of our tasks was the acquiring, configuration and delivery of new computer equipment to our users. We prepared technical specification for several biddings and we verified bids received from the point of view of correctness. Due to financial support from our government, we purchased about one-fourth of our existing computer equipment. This hardware has partially replaced the old units and partially supported our new staff. Implemented at the end of 2006 the Scientific Activity Database has continued its operation and has been extended by several useful reports and fields containing important information. We started preliminary activities related to implementation of video conferencing services in our Institute. Apart of taking part in seminars and consulting several companies, we have managed to transmit a few scientific seminars from Warsaw to our department in Lodz. (author)

  1. Physics division annual report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Thayer, K., ed.; Physics

    2000-12-06

    This report summarizes the research performed in the past year in the Argonne Physics Division. The Division's programs include operation of ATLAS as a national heavy-ion user facility, nuclear structure and reaction research with beams of heavy ions, accelerator research and development especially in superconducting radio frequency technology, nuclear theory and medium energy nuclear physics. The Division took significant strides forward in its science and its initiatives for the future in the past year. Major progress was made in developing the concept and the technology for the future advanced facility of beams of short-lived nuclei, the Rare Isotope Accelerator. The scientific program capitalized on important instrumentation initiatives with key advances in nuclear science. In 1999, the nuclear science community adopted the Argonne concept for a multi-beam superconducting linear accelerator driver as the design of choice for the next major facility in the field a Rare Isotope Accelerator (WA) as recommended by the Nuclear Science Advisory Committee's 1996 Long Range Plan. Argonne has made significant R&D progress on almost all aspects of the design concept including the fast gas catcher (to allow fast fragmentation beams to be stopped and reaccelerated) that in large part defined the RIA concept the superconducting rf technology for the driver accelerator, the multiple-charge-state concept (to permit the facility to meet the design intensity goals with existing ion-source technology), and designs and tests of high-power target concepts to effectively deal with the full beam power of the driver linac. An NSAC subcommittee recommended the Argonne concept and set as tie design goal Uranium beams of 100-kwatt power at 400 MeV/u. Argonne demonstrated that this goal can be met with an innovative, but technically in-hand, design. The heavy-ion research program focused on GammaSphere, the premier facility for nuclear structure gamma-ray studies. One example

  2. Division algebras with integral elements

    International Nuclear Information System (INIS)

    Koca, M.; Ozdes, N.

    1988-06-01

    Pairing two elements of a given division algebra furnished with a multiplication rule leads to an algebra of higher dimension restricted by 8. This fact is used to obtain the roots of SO(4) and SP(2) from the roots ±1 of SU(2) and the weights ±1/2 of its spinor representation. The root lattice of SO(8) described by 24 integral quaternions are obtained by pairing two sets of roots of SP(2). The root system of F 4 is constructed in terms of 24 integral and 24 ''half-integral'' quaternions. The root lattice of E 8 expressed as 240 integral octonions are obtained by pairing two sets of roots of F 4 . 24 integral quaternions of SO(8) forming a discrete subgroup of SU(2) is shown to be the automorphism group of the root lattices of SO(8), F 4 and E 8 . The roots of maximal subgroups SO(16), E 7 XSU(2), E 6 XSU(3), SU(9) and SU(5)XSU(5) of E 8 are identified with a simple method. Subsets of the discrete subgroup of SU(2) leaving maximal subgroups of E 8 are obtained. Constructions of E 8 root lattice with integral octonions in 7 distinct ways are made. Magic square of integral lattices of Goddard, Nahm, Olive, Ruegg and Schwimmer are derived. Possible physical applications are suggested. (author). 16 refs, 6 figs, 5 tabs

  3. 49 CFR 1242.03 - Made by accounting divisions.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Made by accounting divisions. 1242.03 Section 1242... accounting divisions. The separation shall be made by accounting divisions, where such divisions are maintained, and the aggregate of the accounting divisions reported for the quarter and for the year. ...

  4. Metals and Ceramics Division progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    This report provides a brief overview of the activities and accomplishments of the Metals and Ceramics (M C) Division during fiscal year (FY) 1991. The division is organized to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by the US Department of Energy (DOE). Activities span the range from basic research (through applied research and engineering development) to industrial interactions (through cooperative research and a strong technology transfer program). The division is organized in functional groups that encompass nearly all of the disciplines needed to develop and to apply materials in high-temperature applications. Sections I through 5 describe the different functional groups; Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines; and Sect. 7 summarizes external interactions including cooperative research and development programs, educational activities, and technology transfer functions. Appendices describe the organizational structure, note personnel changes, present honors and awards received by division members, and contain listings of publications completed and presentations made at technical meetings.

  5. Metals and Ceramics Division progress report for period ending September 30, 1991

    International Nuclear Information System (INIS)

    1992-03-01

    This report provides a brief overview of the activities and accomplishments of the Metals and Ceramics (M ampersand C) Division during fiscal year (FY) 1991. The division is organized to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by the US Department of Energy (DOE). Activities span the range from basic research (through applied research and engineering development) to industrial interactions (through cooperative research and a strong technology transfer program). The division is organized in functional groups that encompass nearly all of the disciplines needed to develop and to apply materials in high-temperature applications. Sections I through 5 describe the different functional groups; Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines; and Sect. 7 summarizes external interactions including cooperative research and development programs, educational activities, and technology transfer functions. Appendices describe the organizational structure, note personnel changes, present honors and awards received by division members, and contain listings of publications completed and presentations made at technical meetings

  6. Energy Division annual progress report for period ending September 30, 1990

    Energy Technology Data Exchange (ETDEWEB)

    Selden, R.H. (ed.)

    1991-06-01

    The Energy Division is one of 17 research divisions at Oak Ridge National Laboratory. The goals and accomplishments of the Energy Division are described in this annual progress report for FY 1990. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of how societies make choices in energy use; (2) improving society's understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy efficient technologies; and (4) developing improved transportation planning and policy. Disciplines of the 129 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division's programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include building equipment (thermally activated heat pumps, chemical heat pumps, refrigeration systems, novel cycles), building enveloped (walls, foundations, roofs, attics, and materials), retrofits for existing buildings, and electric power systems. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination. 48 refs., 34 figs., 7 tabs.

  7. Insights into the Mechanisms of Chloroplast Division

    Directory of Open Access Journals (Sweden)

    Yamato Yoshida

    2018-03-01

    Full Text Available The endosymbiosis of a free-living cyanobacterium into an ancestral eukaryote led to the evolution of the chloroplast (plastid more than one billion years ago. Given their independent origins, plastid proliferation is restricted to the binary fission of pre-existing plastids within a cell. In the last 25 years, the structure of the supramolecular machinery regulating plastid division has been discovered, and some of its component proteins identified. More recently, isolated plastid-division machineries have been examined to elucidate their structural and mechanistic details. Furthermore, complex studies have revealed how the plastid-division machinery morphologically transforms during plastid division, and which of its component proteins play a critical role in generating the contractile force. Identifying the three-dimensional structures and putative functional domains of the component proteins has given us hints about the mechanisms driving the machinery. Surprisingly, the mechanisms driving plastid division resemble those of mitochondrial division, indicating that these division machineries likely developed from the same evolutionary origin, providing a key insight into how endosymbiotic organelles were established. These findings have opened new avenues of research into organelle proliferation mechanisms and the evolution of organelles.

  8. Division of Scientific Equipment - Overview

    International Nuclear Information System (INIS)

    Halik, J.

    2002-01-01

    Full text: The Scientific Equipment Division consists of the Design Group and the Mechanical Workshop. The activity of the Division includes the following: * designs of devices and equipment for experiments in physics; their mechanical construction and assembly. In particular, these are vacuum chambers and installations for HV and UHV;* maintenance and upgrading of the existing installations and equipment in our Institute; * participation of our engineers and technicians in design works, equipment assembly and maintenance for experiments in foreign laboratories. The Design Group is equipped with PC-computers and AutoCAD graphic software (release 2000 and Mechanical Desktop 4.0) and an A0 plotter, which allow us to make drawings and 2- and 3-dimensional mechanical documentation to the world standards. The Mechanical Workshop offers a wide range of machining and treatment methods with satisfactory tolerances and surface quality. They include: * turning - cylindrical elements of a length up to 2000 mm and a diameter up to 400 mm, and also disc type elements of a diameter up to 600 mm and a length not exceeding 300 mm, * milling - elements of length up to 1000 mm and gear wheels of diameter up to 300 mm, * grinding - flat surfaces of dimensions up to 300 mm x 1000 mm and cylindrical elements of a diameter up to 200 mm and a length up to 800 mm, * drilling - holes of a diameter up to 50 mm, * welding - electrical and gas welding, including TIG vacuum-tight welding, * soft and hard soldering, * mechanical works including precision engineering, * plastics treatment - machining and polishing using diamond milling, modelling, lamination of various shapes and materials, including plexiglas, scintillators and light-guides, * painting - paint spraying with possibility of using furnace-fired drier of internal dimensions of 800 mm x 800 mm x 800 mm. Our workshop is equipped with the CNC milling machine which can be used for machining of work pieces up to 500 kg. The machine

  9. Cell growth and division cycle

    International Nuclear Information System (INIS)

    Darzynkiewicz, Z.

    1986-01-01

    The concept of the cell cycle in its present form was introduced more than three decades ago. Studying incorporation of DNA precursors by autoradiography, these authors observed that DNA synthesis in individual cells was discontinuous and occupied a discrete portion of the cell life (S phase). Mitotic division was seen to occur after a certain period of time following DNA replication. A distinct time interval between mitosis and DNA replication was also apparent. Thus, the cell cycle was subdivided into four consecutive phases, G/sub 1/, S, G/sub 2/, and M. The G/sub 1/ and G/sub 2/ phases represented the ''gaps'' between mitosis and the start of DNA replication, and between the end of DNA replication and the onset of mitosis, respectively. The cell cycle was defined as the interval between the midpoint of mitosis and the midpoint of the subsequent mitosis of the daughter cell(s). The authors' present knowledge on the cell cycle benefited mostly from the development of four different techniques: autoradiography, time-lapse cinematography, cell synchronization and flow cytometry. Of these, autoradiography has been the most extensively used, especially during the past two decades. By providing a means to analyse incorporation of precursors of DNA, RNA or proteins by individual cells and, in combination with various techniques of cell synchronization, autoradiography yielded most of the data fundamental to the current understanding of the cell cycle-related phenomena. Kinetics of cell progression through the cell cycle could be analysed in great detail after development of such sophisticated autoradiographic approaches as measurements of the fraction of labeled mitoses (''FLM curves'') or multiple sequential cell labelling with /sup 3/H- and /sup 14/C-TdR

  10. 49 CFR 175.630 - Special requirements for Division 6.1 (poisonous) material and Division 6.2 (infectious...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Special requirements for Division 6.1 (poisonous... Classification of Material § 175.630 Special requirements for Division 6.1 (poisonous) material and Division 6.2... humans or animals unless: (1) The Division 6.1 or Division 6.2 material and the foodstuff, feed, or other...

  11. Transfer Pricing

    OpenAIRE

    Larsen, Mads Grenaa; Nørgaard, Mads Frid; Hansen, Manjarita

    2013-01-01

    This project seeks to highlight some of the criticisms given towards the OECD Transfer Pricing Guidelines and the challenges Danish companies experience by pricing their goods and the problems this causes for trade. The project is based on a series of interviews that represent the different agents who are operating in Transfer Pricing business. These interviews, combined with the Transfer Pricing Guidelines, gives us the basis to analyse the challenges we want to clarify based on the hypothes...

  12. Chemical Sciences Division annual report 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The division is one of ten LBL research divisions. It is composed of individual research groups organized into 5 scientific areas: chemical physics, inorganic/organometallic chemistry, actinide chemistry, atomic physics, and chemical engineering. Studies include structure and reactivity of critical reaction intermediates, transients and dynamics of elementary chemical reactions, and heterogeneous and homogeneous catalysis. Work for others included studies of superconducting properties of high-{Tc} oxides. In FY 1994, the division neared completion of two end-stations and a beamline for the Advanced Light Source, which will be used for combustion and other studies. This document presents summaries of the studies.

  13. Biology and Medicine Division: Annual report 1986

    International Nuclear Information System (INIS)

    1987-04-01

    The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future

  14. Earth Sciences Division collected abstracts: 1979

    International Nuclear Information System (INIS)

    Henry, A.L.; Schwartz, L.L.

    1980-01-01

    This report is a compilation of abstracts of papers, internal reports, and talks presented during 1979 at national and international meetings by members of the Earth Sciences Division, Lawrence Livermore Laboratory. The arrangement is alphabetical (by author). For a given report, a bibliographic reference appears under the name of each coauthor, but the abstract iself is given only under the name of the first author or the first Earth Sciences Division author. A topical index at the end of the report provides useful cross references, while indicating major areas of research interest in the Earth Sciences Division

  15. Biology and Medicine Division: Annual report 1986

    Energy Technology Data Exchange (ETDEWEB)

    1987-04-01

    The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

  16. Energy Division annual progress report for period ending September 30, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J.N. [ed.

    1992-04-01

    The Energy Division is one of 17 research divisions at Oak Ridge Laboratory. Its goals and accomplishments are described in this annual progress report for FY 1991. The division`s total expenditures in FY 1991 were $39.1 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 124 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The Energy Division`s programmatic activities focus on three major areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities cover energy and resource analysis, the preparation of environmental assessments and impact statements, research on waste management, analysis of emergency preparedness for natural and technological disasters, analysis of the energy and environmental needs of developing countries, technology transfer, and analysis of civilian transportation. Energy conservation technologies include electric power systems, building equipment (thermally activated heat pumps, advanced refrigeration systems, novel cycles), building envelopes (walls, foundations, roofs, attics, and materials), and technical issues for improving energy efficiency in existing buildings. Military transportation systems concentrate on research for sponsors within the US military on improving the efficiency of military deployment, scheduling, and transportation coordination.

  17. Transfer Pricing

    DEFF Research Database (Denmark)

    Rohde, Carsten; Rossing, Christian Plesner

    trade internally as the units have to decide what prices should be paid for such inter-unit transfers. One important challenge is to uncover the consequences that different transfer prices have on the willingness in the organizational units to coordinate activities and trade internally. At the same time...... the determination of transfer price will affect the size of the profit or loss in the organizational units and thus have an impact on the evaluation of managers‟ performance. In some instances the determination of transfer prices may lead to a disagreement between coordination of the organizational units...

  18. Chemical and Laser Sciences Division annual report 1989

    Energy Technology Data Exchange (ETDEWEB)

    Haines, N. (ed.)

    1990-06-01

    The Chemical and Laser Sciences Division Annual Report includes articles describing representative research and development activities within the Division, as well as major programs to which the Division makes significant contributions.

  19. Chemical and Laser Sciences Division annual report 1989

    International Nuclear Information System (INIS)

    Haines, N.

    1990-06-01

    The Chemical and Laser Sciences Division Annual Report includes articles describing representative research and development activities within the Division, as well as major programs to which the Division makes significant contributions

  20. Calidad de vida en el adolescente asmático Quality of life in the asthmatic adolescent

    Directory of Open Access Journals (Sweden)

    Orquídea Aguirre Pérez

    2010-12-01

    Full Text Available INTRODUCCIÓN: la mejoría de la calidad de vida es clave en el tratamiento del niño-adolescente con asma. OBJETIVO: identificar la afectación que provoca el asma bronquial en la calidad de vida del adolescente asmático. MÉTODOS: se realizó un estudio descriptivo, longitudinal y prospectivo de 103 adolescentes asmáticos con diagnóstico de asma leve intermitente, asma leve persistente y asma moderada persistente en la Escuela Secundaria Básica "Antonio José de Sucre", en la localidad de Cojímar, en el período entre el 1ro. de enero de 2006 y el 31 de diciembre del propio año. RESULTADOS: los síntomas principales fueron la tos, la disnea y la sibilancia, y las molestias más frecuentes, el cansancio, la dificultad para respirar hondo y la sensación de quedar sin aire. Predominó el sexo masculino y las edades de 12 y 13 años. El mayor número de respuestas de las alteraciones de la función emocional se concentraba en las categorías más bajas del nivel de afectación, y las respuestas sobre la limitación de la actividad motora se inclinaron hacia las categorías de muchísimo, mucho, bastante y regular. Predominó la afectación moderada de la calidad de vida. El asma persistente moderada fue la mayormente referida en la afectación de calidad de vida severa.INTRODUCTION: the improvement in quality of life is a key element in treatment of asthmatic child-adolescent. OBJECTIVE: to identify the affection provoking the bronchial asthma in the quality of life of the asthmatic adolescent. METHODS: a prospective longitudinal and descriptive study was conducted in 103 asthmatic adolescents diagnosed with intermittent slight asthma from the "Antonio José de Sucre" Secondary Basic School in the Cojimar place, from January 1, to December 31, 2006. RESULTS: the major symptoms included cough, dyspnea and sibilation and the more frequent nuisances were the tiredness, profound breathlessness and the feeling of lack of air. There was

  1. Progress report, Health Sciences Division

    International Nuclear Information System (INIS)

    1980-11-01

    A re-designed automatic TLD reader has been constructed. The thermoluminescent material MgB 4 O 7 :Dy appears to be attractive for environmental gamma monitoring. The field prototype of a simple, light weight tritium monitor is being built, and field-tests of a pocket warning dosimeter have been completed. A computer program for the calculation of beta doses from point and plane sources has been used to calculate distributions for 90 nuclides. Research into the adsorption of 134 Cs, 60 Co and 90 Sr onto soil particles and processes associated with the release of these nuclides is continuing. Studies are being carried out into the culture of algae in municipal wastewater, heat and solute transfer in lakes, and groundwater seepage flow into lakes. Radiation biology work continues to deal with radiation damage of DNA and cellular repair mechanisms. A metabolic model for the tellurium-iodine decay chain has been completed. (LL)

  2. Seguimiento del paciente asmático: qué debe saber el farmacéutico comunitario

    Directory of Open Access Journals (Sweden)

    Plaza Zamora J

    2013-03-01

    Full Text Available El asma tiene una prevalencia de entre un 1 y un 18% dependiendo del país. En el proceso de atención al paciente, y a través de los síntomas que presenta (disnea, tos, sibilancias, opresión torácica, el farmacéutico comunitario puede hacer educación sanitaria para evitar los agentes causales del asma, sobre cómo usar el dispositivo de inhalación prescrito por el médico, explicar al paciente su medicación, cómo es su tratamiento para conocer mejor su enfermedad, qué signos y síntomas denotan una falta de control de la misma, qué métodos se pueden usar para monitorizar la evolución del asma, detectar una posible falta de efectividad del tratamiento por tener sintomatología a pesar de estar usando adecuadamente el dispositivo de inhalación, sospechar que exista algún medicamento causante del asma, repasar el resto de medicación que usa por si existieran interacciones que afectaran tanto a la efectividad como a la seguridad del tratamiento. Existe un importante infradiagnóstico del asma, un 57,5% según el ECRHS (siglas del inglés European Community Respiratory Health Survey. En la farmacia comunitaria se puede hacer cribado de la enfermedad con la ayuda de cuestionarios validados en niños y no validados en adultos. Mediante la presente revisión se pretende ofrecer al farmacéutico comunitario una herramienta práctica para su labor diaria de atención al paciente asmático.

  3. Maduración sexual en una muestra de niños asmáticos

    Directory of Open Access Journals (Sweden)

    Gladys Abreu Suárez

    1996-04-01

    Full Text Available Con el objetivo de evaluar la repercusión del asma bronquial sobre la maduración sexual, se estudiaron en un corte transversal 180 niños asmáticos de uno y otro sexos, entre 7 y 15 años de edad, procedentes de la consulta externa del Hospital Pediátrico Docente de Centro Habana. A todos los niños se les evaluó el peso, la talla, los pliegues grasos y la maduración sexual y esquelética. Las medias de peso, talla y pliegues grasos se correspondieron con valores reportados en niños sanos. No se encontró retardo en la maduración sexual; la mayoría de los niños con estadios puberales avanzados se agruparon en los canales más altos de edad ósea.With the aim of assessing the effects of bronchial asthma on sex maturation, a cross-sectional study was carried out in 180 asthmatic children of both sexes, between 7 and 15 years old, outpatients coming from the Educational Pediatric Hospital at Centro Habana. An evaluation was made to all the children, and it included body weight, body height, skinfold thickness, bone development and sex maturation. Means in weight, height, and skinfold thickness were correspondent with the values reported for healthy children. No retardation was found in sex maturation; most part of the children with advanced pubertal stages were gathered in the highest channels of skeletal age.

  4. Applications of isotopy to real division algebras

    Energy Technology Data Exchange (ETDEWEB)

    Benkart, G. (Univ. of Wisconsin, Madison); Osborn, J.M.; Britten, D.

    1981-02-01

    In this paper we illustrate how the notion of isotopy can be used to solve various problems concerning finite-dimensional division algebras over the real numbers. In particular, we show that the 8-dimensional division algebras which have the same derivation algebra as the octonions, and hence which most resemble the octonions, are not in general isotopes of the octonions. Secondly, using a result of Hopf, we argue that every commutative division algebra is the reals or is isomorphic to a special kind of isotope of the complex numbers. Finally, by considering a certain class of algebras, we show how isotopy is a useful tool for determining necessary and sufficient conditions on the multiplication constants in order to have a division algebra.

  5. Spatial Divisions and Fertility in India

    Directory of Open Access Journals (Sweden)

    Vijayan Pillai

    2012-01-01

    Full Text Available The Indian subcontinent can be divided into four geographical divisions. In this paper, we characterize three of the four divisions; the Northern Plains, the Deccan Plateau, and the Northern Mountains or the Himalayan as regions with dissimilar climatic and physical resources. It is argued that human adaptations to these variations would be varied by differences in social organization of production and consumption resulting in differences in fertility differences across the three divisions. We found significant differences in the median age at motherhood as well as in the total family size. The effects of the three selected fertility determinants, age at marriage, years of woman's education, and level of child loss on family size also varied significantly across the three divisions. There is considerable homogeneity with respect to fertility levels within the zones considered in this study.

  6. Chemical Sciences Division: Annual report 1992

    International Nuclear Information System (INIS)

    1993-10-01

    The Chemical Sciences Division (CSD) is one of twelve research Divisions of the Lawrence Berkeley Laboratory, a Department of Energy National Laboratory. The CSD is composed of individual groups and research programs that are organized into five scientific areas: Chemical Physics, Inorganic/Organometallic Chemistry, Actinide Chemistry, Atomic Physics, and Physical Chemistry. This report describes progress by the CSD for 1992. Also included are remarks by the Division Director, a description of work for others (United States Office of Naval Research), and appendices of the Division personnel and an index of investigators. Research reports are grouped as Fundamental Interactions (Photochemical and Radiation Sciences, Chemical Physics, Atomic Physics) or Processes and Techniques (Chemical Energy, Heavy-Element Chemistry, and Chemical Engineering Sciences)

  7. Chemical Sciences Division: Annual report 1992

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The Chemical Sciences Division (CSD) is one of twelve research Divisions of the Lawrence Berkeley Laboratory, a Department of Energy National Laboratory. The CSD is composed of individual groups and research programs that are organized into five scientific areas: Chemical Physics, Inorganic/Organometallic Chemistry, Actinide Chemistry, Atomic Physics, and Physical Chemistry. This report describes progress by the CSD for 1992. Also included are remarks by the Division Director, a description of work for others (United States Office of Naval Research), and appendices of the Division personnel and an index of investigators. Research reports are grouped as Fundamental Interactions (Photochemical and Radiation Sciences, Chemical Physics, Atomic Physics) or Processes and Techniques (Chemical Energy, Heavy-Element Chemistry, and Chemical Engineering Sciences).

  8. Environmental Research Division's Data Access Program (ERDDAP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ERDDAP (the Environmental Research Division's Data Access Program) is a data server that gives you a simple, consistent way to download subsets of scientific...

  9. Earth Sciences Division annual report 1981

    International Nuclear Information System (INIS)

    1982-09-01

    Separate abstracts were prepared for the 59 papers of the 1981 annual report of the Earth Sciences Division at Lawrence Berkeley Laboratory. The general topics covered included nuclear waste isolation, geophysics and reservoir engineering, and geosciences

  10. Theoretical Division annual report, FY 1975

    International Nuclear Information System (INIS)

    Carruthers, P.A.

    1976-02-01

    This report presents an overview of the activities in the Theoretical Division and a summary of research highlights during FY 1975. It is intended to inform a wide audience about the theoretical work of the LASL and, therefore, contains introductory material which places recent advances in a broader context. The report is organized into two special interest reports: reactor safety research and the Advanced Research Committee, and 11 reports from the T-Division group leaders on the work of their respective groups. Main interests and responsibilities are outlined including the relationship of the group's work to the work of other T-Division groups and other divisions at the Laboratory. The description of research highlights for FY 1975 explains in a fairly simple, straightforward manner the major recent advances and their significance. Each group report is followed by a publication list for FY 1975 (330 references) and a list of talks given outside the Laboratory (140 references). 29 figures

  11. Civil Remedies Division Administrative Law Judge Decisions

    Data.gov (United States)

    U.S. Department of Health & Human Services — Decisions issued by Administrative Law Judges of the Departmental Appeals Board's Civil Remedies Division concerning fraud and abuse determinations by the Office of...

  12. Accelerator Technology Division: Annual Report FY 1990

    National Research Council Canada - National Science Library

    Schriber, Stanley

    1991-01-01

    The Accelerator Technology (AT) Division continued in fiscal year 1990 to fulfill its mission of developing accelerator science and technology for application to research, defense, energy, and other problems of national interest...

  13. DNR Division of Enforcement Officer Patrol Areas

    Data.gov (United States)

    Minnesota Department of Natural Resources — This theme shows the DNR Division of Enforcement Office Patrol Areas as of January 1, 2003. Patrol areas were defined and verified by Patrol Officers during the fall...

  14. Energy Division annual progress report for period ending September 30, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Counce, D.M.; Wolff, P.P. [eds.

    1993-04-01

    Energy Division`s mission is to provide innovative solutions to energy and related Issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY 1992. Energy Division`s total expenditures in FY 1992 were $42.8 million. The work is supported by the US Department of Energy, the US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 116.5 technical staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy conservation technologies, and (3) military transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on waste management, technology transfer, analysis of energy and environmental needs in developing countries, and civilian transportation analysis. Energy conservation technologies focus on electric power systems, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Military transportation systems conduct research for sponsors within the US military to improve the efficiency of military deployment, scheduling, and transportation coordination. Much of Energy Division`s research is valuable to other organizations as well as to sponsors. This information is disseminated by the staff`s involvement in professional and trade organizations and workshops; joint research with universities and private-sector firms; collaboration with state and local governments; presentation of work at conferences; and publication of research results in journals, reports, and conference proceedings.

  15. Energy Division annual progress report for period ending September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, P.P. [ed.

    1994-07-01

    One of 17 research divisions at Oak Ridge National Laboratory, Energy Division`s mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this annual progress report for FY1993. Energy Division is committed to (1) understanding the mechanisms by which societies make choices in energy use; (2) improving society`s understanding of the environmental, social, and economic implications of technological change; (3) developing and transferring energy-efficient technologies; (4) improving transportation policy and planning; (5) enhancing basic knowledge in the social sciences as related to energy and associated issues. Energy Division`s expenditures in FY1993 totaled $42 million. The work was supported by the US DOE, DOD, many other federal agencies, and some private organizations. Disciplines of the 126.5 technical staff members include engineering, social sciences, physical and life sciences, and computer sciences and data systems. The division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) energy use and delivery technologies, and (3) transportation systems. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, research on emergency preparedness, transportation analysis, and analysis of energy and environmental needs in developing countries. Energy use and delivery technologies focus on electric power systems, building equipment, building envelopes (walls, foundations, roofs, attics, and materials), and methods to improve energy efficiency in existing buildings. Transportation systems research is conducted both to improve the quality of civilian transportation and for sponsors within the US military to improve the efficiency of deployment, scheduling, and transportation coordination.

  16. Transfer Pricing

    DEFF Research Database (Denmark)

    Rohde, Carsten; Rossing, Christian Plesner

    trade internally as the units have to decide what prices should be paid for such inter-unit transfers. One important challenge is to uncover the consequences that different transfer prices have on the willingness in the organizational units to coordinate activities and trade internally. At the same time...

  17. Radiochemistry Division annual progress report : 1991

    International Nuclear Information System (INIS)

    Natarajan, V.; Godbole, S.V.; Iyer, R.H.

    1993-01-01

    The research and development activities of the Radiochemistry Division during 1991 are briefly described under the headings: (i) Nuclear chemistry, (ii) Actinide chemistry, and (iii) Spectroscopy. In the field of nuclear chemistry, the main emphasis has been on the studies of fission process induced by reactor neutrons and light and heavy ions on actinides and low Z (Z c superconductors. A list of publications by the scientific staff of the Division is given at the end. (author). 31 figs., 49 tabs

  18. Stationary infinitely divisible processes

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole E.

    Several recent strands of work has led to the consideration of various types of continuous time stationary and infinitely divisible processes. A review of these types, with some new results, is presented.......Several recent strands of work has led to the consideration of various types of continuous time stationary and infinitely divisible processes. A review of these types, with some new results, is presented....

  19. Nuclear Science Division: 1993 Annual report

    International Nuclear Information System (INIS)

    Myers, W.D.

    1994-06-01

    This report describes the activities of the Nuclear Science Division for the 1993 calendar year. This was another significant year in the history of the Division with many interesting and important accomplishments. Activities for the following programs are covered here: (1) nuclear structure and reactions program; (2) the Institute for Nuclear and Particle Astrophysics; (3) relativistic nuclear collisions program; (4) nuclear theory program; (5) nuclear data evaluation program, isotope project; and (6) 88-inch cyclotron operations

  20. TAX ASPECTS REGARDING THE MERGER AND DIVISION

    Directory of Open Access Journals (Sweden)

    BRAGĂ FILOFTEIA VIORICA

    2014-05-01

    Full Text Available In this paper, we want to present the tax issues that influencing the merger and division starting from the economic context characterized by a lack of liquidity, business reorganization to streamline the business and from the advantages and disadvantages of this operation achievement. The documentation was performed by consulting the Tax Code, the Methodological Norms regarding the accounting operations of merger, division, liquidation and professional literature.

  1. Medical Sciences Division report for 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    This year`s Medical Sciences Division (MSD) Report is organized to show how programs in our division contribute to the core competencies of Oak Ridge Institute for Science and Education (ORISE). ORISE`s core competencies in education and training, environmental and safety evaluation and analysis, occupational and environmental health, and enabling research support the overall mission of the US Department of Energy (DOE).

  2. Earth Sciences Division, collected abstracts, 1978

    International Nuclear Information System (INIS)

    Taasevigen, D.K.; Henry, A.L.; Madsen, S.K.

    1979-01-01

    Abstracts of papers, internal reports, and talks presented during 1978 at national and international meetings by members of the Earth Sciences Division of the Lawrence Livermore Laboratory are compiled. The arrangement is alphabetical (by author). For any given report, a bibliographic reference appears under the name of each coauthor. A topical index at the end provides useful cross references, while indicating major areas of research interest in the Earth Sciences Division

  3. A division algebra classification of generalized supersymmetries

    International Nuclear Information System (INIS)

    Toppan, Francesco

    2004-10-01

    Generalized supersymmetries admitting bosonic tensor central charges are classified in accordance with their division algebra properties. Division algebra consistent constraints lead (in the complex and quaternionic cases) to the classes of hermitian and holomorphic generalized supersymmetries. Applications to the analytic continuation of the M-algebra to the Euclidean and the systematic investigation of certain classes of models in generic space-times are briefly mentioned. (author)

  4. Earth Sciences Division annual report 1989

    Energy Technology Data Exchange (ETDEWEB)

    1990-06-01

    This Annual Report presents summaries of selected representative research activities from Lawrence Berkeley Laboratory grouped according to the principal disciplines of the Earth Sciences Division: Reservoir Engineering and Hydrology, Geology and Geochemistry, and Geophysics and Geomechanics. We are proud to be able to bring you this report, which we hope will convey not only a description of the Division's scientific activities but also a sense of the enthusiasm and excitement present today in the Earth Sciences.

  5. Weapons Experiments Division Explosives Operations Overview

    Energy Technology Data Exchange (ETDEWEB)

    Laintz, Kenneth E. [Los Alamos National Laboratory

    2012-06-19

    Presentation covers WX Division programmatic operations with a focus on JOWOG-9 interests. A brief look at DARHT is followed by a high level overview of explosives research activities currently being conducted within in the experimental groups of WX-Division. Presentation covers more emphasis of activities and facilities at TA-9 as these efforts have been more traditionally aligned with ongoing collaborative explosive exchanges covered under JOWOG-9.

  6. The stem cell division theory of cancer.

    Science.gov (United States)

    López-Lázaro, Miguel

    2018-03-01

    All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and lung cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations and epigenetic mistakes occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the

  7. Nuclear Science Division: 1993 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Myers, W.D. [ed.

    1994-06-01

    This report describes the activities of the Nuclear Science Division for the 1993 calendar year. This was another significant year in the history of the Division with many interesting and important accomplishments. Activities for the following programs are covered here: (1) nuclear structure and reactions program; (2) the Institute for Nuclear and Particle Astrophysics; (3) relativistic nuclear collisions program; (4) nuclear theory program; (5) nuclear data evaluation program, isotope project; and (6) 88-inch cyclotron operations.

  8. Nuclear Physics Division annual report 1992

    International Nuclear Information System (INIS)

    Betigeri, M.G.

    1993-01-01

    The report covers the research and development activities of the Nuclear Physics Division for the period January to December 1992. These research and development activities are reported under the headings: 1) Experiments, 2) Theory, 3) Applications, 4) Instrumentation, and 5) The Pelletron Accelerator. At the end a list of publications by the staff scientists of the Division is given. Colloquia and seminars held during the year are also listed. (author). refs., tabs., figs

  9. Fuel Chemistry Division: progress report for 1987

    International Nuclear Information System (INIS)

    1990-01-01

    The progress of research and development activities of the Fuel Chemistry Division of the Bhabha Atomic Research Centre, Bombay, during 1987 is reported in the form of summaries which are arranged under the headings: Fuel Development Chemistry, Chemistry of Actinides, Chemical Quality Control of Fuel, and Studies related to Nuclear Material Accounting. A list of publications by the members of the Division during the report period is given at the end of the report. (M.G.B.). refs., 15 figs., 85 tabs

  10. Earth Sciences Division collected abstracts: 1980

    Energy Technology Data Exchange (ETDEWEB)

    Henry, A.L.; Hornady, B.F. (eds.)

    1981-10-15

    This report is a compilation of abstracts of papers, reports, and talks presented during 1980 at national and international meetings by members of the Earth Sciences Division, Lawrence Livermore National Laboratory. The arrangement is alphabetical (by author). For a given report, a bibliographic reference appears under the name of each coauthor, but the abstract itself is given only under the name of the first author (indicated in capital letters) or the first Earth Sciences Division author.

  11. Earth Sciences Division collected abstracts: 1980

    International Nuclear Information System (INIS)

    Henry, A.L.; Hornady, B.F.

    1981-01-01

    This report is a compilation of abstracts of papers, reports, and talks presented during 1980 at national and international meetings by members of the Earth Sciences Division, Lawrence Livermore National Laboratory. The arrangement is alphabetical (by author). For a given report, a bibliographic reference appears under the name of each coauthor, but the abstract itself is given only under the name of the first author (indicated in capital letters) or the first Earth Sciences Division author

  12. Transfer Pricing

    DEFF Research Database (Denmark)

    Nielsen, Søren Bo

    2014-01-01

    Against a background of rather mixed evidence about transfer pricing practices in multinational enterprises (MNEs) and varying attitudes on the part of tax authorities, this paper explores how multiple aims in transfer pricing can be pursued across four different transfer pricing regimes. A MNE has...... a production subsidiary in one country, from where it sells the produced good locally as well as to a sales subsidiary in a second country. The latter subsidiary is engaged in duopolistic competition with a local competitor. The MNE has two aims in setting the transfer price: strategic delegation and tax...... minimization. We examine the extent to which the four transfer pricing regimes we set up allow the MNE to pursue these aims. While neither strategic delegation nor tax minimization will be eliminated, trade-offs are inevitable, albeit to varying degree....

  13. Transfer Pricing

    DEFF Research Database (Denmark)

    Nielsen, Søren Bo

    2014-01-01

    a production subsidiary in one country, from where it sells the produced good locally as well as to a sales subsidiary in a second country. The latter subsidiary is engaged in duopolistic competition with a local competitor. The MNE has two aims in setting the transfer price: strategic delegation and tax......Against a background of rather mixed evidence about transfer pricing practices in multinational enterprises (MNEs) and varying attitudes on the part of tax authorities, this paper explores how multiple aims in transfer pricing can be pursued across four different transfer pricing regimes. A MNE has...... minimization. We examine the extent to which the four transfer pricing regimes we set up allow the MNE to pursue these aims. While neither strategic delegation nor tax minimization will be eliminated, trade-offs are inevitable, albeit to varying degree....

  14. Energy Technology Division research summary 2001

    International Nuclear Information System (INIS)

    2001-01-01

    The Energy Technology Division provides materials and engineering technology support to a wide range of programs important to the U.S. Department of Energy. As shown on the preceding page, the Division is organized into eight sections, four with concentrations in the materials area and four in engineering technology. Materials expertise includes fabrication, mechanical properties, corrosion, friction and lubrication, and irradiation effects. Our major engineering strengths are in heat and mass flow, sensors and instrumentation, nondestructive testing, transportation, and electromechanics and superconductivity applications. The Division Safety Coordinator, Environmental Compliance Officer, Quality Assurance Representative, Financial Administrator, and Communication Coordinator report directly to the Division Director. The Division Director is personally responsible for cultural diversity and is a member of the Laboratory-wide Cultural Diversity Advisory Committee. This Overview highlights some major ET research areas. Research related to the operational safety of commercial light water nuclear reactors (LWRs) for the U.S. Nuclear Regulatory Commission (NRC) remains a significant area of interest for the Division. We currently have programs on environmentally assisted cracking, steam generator integrity, and the integrity of high-burnup fuel during loss-of-coolant accidents. The bulk of the NRC research work is carried out by three ET sections: Corrosion and Mechanics of Materials; Irradiation Performance; and Sensors, Instrumentation, and Nondestructive Evaluation

  15. Division of Information Technology - Overview

    International Nuclear Information System (INIS)

    Szlachciak, J.

    2010-01-01

    Full text: The Division of Information Technology continued its service-oriented activities in 2009. Our main duty was day-to-day support to all units in the Institute in IT related matters. One of our tasks was the acquiring, configuration and delivery of new computer equipment to our users. We automated the standard software installation task and decreased the delivery time for new and fully reconfigured computers to end users. We prepared the technical specifications for several bid and we verified thai the received bids complied with the specification. In addition to regular purchasing of computer equipment we supported the special software -related needs of EU projects. We purchased new licenses for: Computer Simulation Technology Studio Suite, Pulsar Physics General Particle Tracerm. Altium Designer. Autodesk Inventor. Autodesk AutoCAD Electrical, Altera Quartus II. Lahey/Fujitsu Fortran Professional. Code Gear Delphi, Steema Software TeeChart Pro, ANSYS Academic Research, Math Works Matlab, Keil PK51 Professional Developer's Kit, Corel Corporation CorelDraw Graphics Suite, Abbyy FineReader Professional, Adobe Acrobat Professional. We also renewed and increased the number of licenses for Microsoft and GFI products. We implemented a full high definition video conferencing system based on equipment from Lifesize. One-video conferencing terminal is placed in Swierk. another, enabling 4-way conferences, is located in Warsaw. This equipment is mainly used for teleconferences between our Institute and our partners in DESY and CERN. By the implementation of such a system we significantly improved the exchange of information and saved on travel costs. In addition the rooms housing the video conferencing systems were equipped with professional data projectors. We continued the modernization of the Local Area Network infrastructure. The first main achievement was a full replacement of cables and active network devices in the building where the Departments of Plasma

  16. Telemonitorização domiciliária de insuficientes respiratórios crónicos graves e de doentes asmáticos Home telemonitoring of severe chronic respiratory insufficient and asthmatic patients

    Directory of Open Access Journals (Sweden)

    Manuela Zamith

    2009-05-01

    Full Text Available Durante nove meses avaliámos um dispositivo portátil para transferência de dados pela Internet entre doentes e profissionais de saúde: oximetria, ECG, respostas a questionários e mensagens. Foram incluídos 51 insuficientes respiratórios crónicos (IRC graves acompanhados no Hospital de Pulido Valente (Lisboa e no Hospital do Espírito Santo (Évora e 21 asmáticos deste último hospital. A utilização e a aceitação deste dispositivo foram avaliadas através de questionários que registaram a opinião dos doentes e dos profissionais de saúde. Nos IRC de Lisboa avaliou -se a repercussão deste programa sobre internamentos hospitalares e qualidade de vida dos doentes. Aprender a utilizar o sistema foi mais difícil para os doentes IRC; a maioria (80% teve problemas com o equipamento, qualificados como raros/ocasionais em 62% dos casos. Para 31 doentes IRC seguidos no hospital de Lisboa, a utilização do sistema foi classificada como correcta em12 doentes, incorrecta em 7 e razoável em12 doentes. Os primeiros tiveram redução do número e duração dos internamentos em relação a igual período anterior ao programa de telemonitorização e melhoria da qualidade de vida, em particular no domínio da actividade. Com este sistema de telemonitorização 80% dos doentes IRC sentiram -se mais/muito mais apoiados e 33 (75% utilizariam este sistema no futuro, se ele estivesse disponível. No grupo de doentes asmáticos, 81% gostariam de manter este tipo de vigilância. O serviço foi considerado útil pelos investigadores. Concluímos que a telemonitorização domiciliária constitui uma contribuição positiva para a gestão dos doentes crónicos e a sua divulgação deverá ser considerada no futuro.For 9 months we evaluated a portable device to transfer patient-clinician data by Internet: oximetry, ECG, clinical questionnaires and messages from the doctor. Fifty-one patients with severe chronic respiratory insufficiency (CRI were followed

  17. Energy Technology Division research summary - 1999.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-31

    The Energy Technology Division provides materials and engineering technology support to a wide range of programs important to the US Department of Energy. As shown on the preceding page, the Division is organized into ten sections, five with concentrations in the materials area and five in engineering technology. Materials expertise includes fabrication, mechanical properties, corrosion, friction and lubrication, and irradiation effects. Our major engineering strengths are in heat and mass flow, sensors and instrumentation, nondestructive testing, transportation, and electromechanics and superconductivity applications. The Division Safety Coordinator, Environmental Compliance Officers, Quality Assurance Representative, Financial Administrator, and Communication Coordinator report directly to the Division Director. The Division Director is personally responsible for cultural diversity and is a member of the Laboratory-wide Cultural Diversity Advisory Committee. The Division's capabilities are generally applied to issues associated with energy production, transportation, utilization, or conservation, or with environmental issues linked to energy. As shown in the organization chart on the next page, the Division reports administratively to the Associate Laboratory Director (ALD) for Energy and Environmental Science and Technology (EEST) through the General Manager for Environmental and Industrial Technologies. While most of our programs are under the purview of the EEST ALD, we also have had programs funded under every one of the ALDs. Some of our research in superconductivity is funded through the Physical Research Program ALD. We also continue to work on a number of nuclear-energy-related programs under the ALD for Engineering Research. Detailed descriptions of our programs on a section-by-section basis are provided in the remainder of this book.

  18. The History of Metals and Ceramics Division

    Energy Technology Data Exchange (ETDEWEB)

    Craig, D.F.

    1999-01-01

    The division was formed in 1946 at the suggestion of Dr. Eugene P. Wigner to attack the problem of the distortion of graphite in the early reactors due to exposure to reactor neutrons, and the consequent radiation damage. It was called the Metallurgy Division and assembled the metallurgical and solid state physics activities of the time which were not directly related to nuclear weapons production. William A. Johnson, a Westinghouse employee, was named Division Director in 1946. In 1949 he was replaced by John H Frye Jr. when the Division consisted of 45 people. He was director during most of what is called the Reactor Project Years until 1973 and his retirement. During this period the Division evolved into three organizational areas: basic research, applied research in nuclear reactor materials, and reactor programs directly related to a specific reactor(s) being designed or built. The Division (Metals and Ceramics) consisted of 204 staff members in 1973 when James R. Weir, Jr., became Director. This was the period of the oil embargo, the formation of the Energy Research and Development Administration (ERDA) by combining the Atomic Energy Commission (AEC) with the Office of Coal Research, and subsequent formation of the Department of Energy (DOE). The diversification process continued when James O. Stiegler became Director in 1984, partially as a result of the pressure of legislation encouraging the national laboratories to work with U.S. industries on their problems. During that time the Division staff grew from 265 to 330. Douglas F. Craig became Director in 1992.

  19. Expression of the nucleus-encoded chloroplast division genes and proteins regulated by the algal cell cycle.

    Science.gov (United States)

    Miyagishima, Shin-Ya; Suzuki, Kenji; Okazaki, Kumiko; Kabeya, Yukihiro

    2012-10-01

    Chloroplasts have evolved from a cyanobacterial endosymbiont and their continuity has been maintained by chloroplast division, which is performed by the constriction of a ring-like division complex at the division site. It is believed that the synchronization of the endosymbiotic and host cell division events was a critical step in establishing a permanent endosymbiotic relationship, such as is commonly seen in existing algae. In the majority of algal species, chloroplasts divide once per specific period of the host cell division cycle. In order to understand both the regulation of the timing of chloroplast division in algal cells and how the system evolved, we examined the expression of chloroplast division genes and proteins in the cell cycle of algae containing chloroplasts of cyanobacterial primary endosymbiotic origin (glaucophyte, red, green, and streptophyte algae). The results show that the nucleus-encoded chloroplast division genes and proteins of both cyanobacterial and eukaryotic host origin are expressed specifically during the S phase, except for FtsZ in one graucophyte alga. In this glaucophyte alga, FtsZ is persistently expressed throughout the cell cycle, whereas the expression of the nucleus-encoded MinD and MinE as well as FtsZ ring formation are regulated by the phases of the cell cycle. In contrast to the nucleus-encoded division genes, it has been shown that the expression of chloroplast-encoded division genes is not regulated by the host cell cycle. The endosymbiotic gene transfer of minE and minD from the chloroplast to the nuclear genome occurred independently on multiple occasions in distinct lineages, whereas the expression of nucleus-encoded MIND and MINE is regulated by the cell cycle in all lineages examined in this study. These results suggest that the timing of chloroplast division in algal cell cycle is restricted by the cell cycle-regulated expression of some but not all of the chloroplast division genes. In addition, it is

  20. Station Transfers

    Data.gov (United States)

    Department of Homeland Security — ixed rail transit external system transfers for systems within the Continental United States, Alaska, Hawaii, the District of Columbia, and Puerto Rico. The modes of...

  1. Energy and Environmental Systems Division 1981 research review

    International Nuclear Information System (INIS)

    1982-04-01

    To effectively manage the nation's energy and natural resources, government and industry leaders need accurate information regarding the performance and economics of advanced energy systems and the costs and benefits of public-sector initiatives. The Energy and Environmental Systems Division (EES) of Argonne National Laboratory conducts applied research and development programs that provide such information through systems analysis, geophysical field research, and engineering studies. During 1981, the division: analyzed the production economics of specific energy resources, such as biomass and tight sands gas; developed and transferred to industry economically efficient techniques for addressing energy-related resource management and environmental protection problems, such as the reclamation of strip-mined land; determined the engineering performance and cost of advanced energy-supply and pollution-control systems; analyzed future markets for district heating systems and other emerging energy technologies; determined, in strategic planning studies, the availability of resources needed for new energy technologies, such as the imported metals used in advanced electric-vehicle batteries; evaluated the effectiveness of strategies for reducing scarce-fuel consumption in the transportation sector; identified the costs and benefits of measures designed to stabilize the financial condition of US electric utilities; estimated the costs of nuclear reactor shutdowns and evaluated geologic conditions at potential sites for permanent underground storage of nuclear waste; evaluated the cost-effectiveness of environmental regulations, particularly those affecting coal combustion; and identified the environmental effects of energy technologies and transportation systems

  2. A avaliação da Qualidade de Vida no Doente Asmático

    Directory of Open Access Journals (Sweden)

    C.H. Leroyer

    1998-11-01

    Full Text Available RESUMO: A avaliarção da Qualidade de Vida (QV do doente respiratório crónico, tem suscitado um interesse cresceote nos últimos anos. O conceito de QV é complexo, sendo, segundo o grupo de trabalho da OMS sobre este tema: “… influenciado pelo estado de saúde fisico, psicológico, o grau de independência, a inserrção social e as relarções com os constituintes essenciais do meio ambiente”. Neste trabalho, os autores abordam a importância e o lugar da avaliação da QV no estudo do doente com asma brônquica e analisam OS diferéntes métodos de avaliação disponíveis.Tal como as outras doenças respiratórias crónicas, a asma tem repercussões na qualidade de vida dos doentes. Como resposta, o.doente asmàtico pode desenvolver mecanismos de adaptação complexos, ex: diminuir o seu nível de actividade funcional (fenómeno de “normalidade ajustada” em que ao fim de certo tempo, a incapacidade para a realização de certas actividades fisicas é assumido pelo doente como “normal”. A avaliação da qualidade de vida deve, nestes casos, ser capaz de evidenciar a real limitação da actividade do doente.Os factores exteriores (ex: elirna, também exercem uma influência determinante sobre o doente asmátìco. Em resposta a estes, o doente pode limitar a sua actividadc (ex: evitar ambientcs enfumarados ou evitar o exercicio ao ar livre nos dias frios ou pode alterar o meio ambientc (ex: medidas de evicção dos ácaros.A asma brônquica afecta três domínios da vida do indivíduo: Físico, Psíquico e Social. Como resultado, a avaliarção da QV do doente asmático é um estudo pluridimensional e deve ser encarada como complementar dos restantes indicadores habitualmente empregues no estudo da asma (estudo funcional respiratório, análiscs, “scores” clinicos, etc.. Além disso

  3. Nuclear Physics Division biennial report 1993-1994

    International Nuclear Information System (INIS)

    Kumar, K.; Kataria, S.K.

    1995-01-01

    The activities of the Nuclear Physics Division of Bhabha Atomic Research Centre for the two year period January 1993 to December 1994 are summarised. The experimental nuclear physics research activities are centred around the 14 UD Pelletron accelerator. Instrumentation development for the research utilization of the accelerator as well as accelerator development activities connected with the superconducting LINAC booster are included. During the period the conversion of the 5.5 MV single stage Van de Graaff Accelerator into a 7 MV folded tandem accelerator for light and heavy ions, for use not only in low energy nuclear physics but also in various inter-disciplinary areas was carried out. The research activity in the field of study of heavy ion reactions involving elastic scattering, transfer reactions, fusion-fission phenomena, heavy ion resonances, high energy photons in nuclear reactions and level density determination from charged particle spectra emitted in heavy ion reactions are given. (author). refs., figs., tabs

  4. A practical example of code comparison evaluation of conformance to the Asme 3 code of large nuclear replacement parts manufactured according to RCC-M

    International Nuclear Information System (INIS)

    Dunand-Roux, L.; Berger, T.; Grandemange, J.M.; Lemoine, M.

    2004-01-01

    This paper summarizes the work carried out to evaluate the compliance of a French RCC-M practice with the ASME Code, for installation of pressurized water reactor closure heads manufactured as per the French regulations, on American nuclear power plants. This evaluation covers all requirements regarding: - Materials and purchases, - Design and analysis, - Manufacturing, welding and related qualifications, - Non-destructive inspections. On completion of this evaluation, a number of additional justifications were produced, revealing that the technical solutions retained are compatible with both construction codes. (authors)

  5. Report on the activities of the ASME-NQA Committee Working Group on Quality Assurance Requirements for Research and Development, April 1990 to August 1991

    Energy Technology Data Exchange (ETDEWEB)

    Dronkers, J.J.

    1991-09-01

    This report transmits to the public eye the activities of the American Society of Mechanical Engineers-Nuclear Quality Assurance (ASME-NQA) Committee Working Group on Quality Assurance Requirements for Research and Development. The appendix lists the members of this group as of August 1991. The report covers a period of 17 months. The working group met eight times in this period, and much intellectual ground was traversed. There was seldom agreement on the nature of the task, but there was no doubt as to its urgency. The task was how to adapt the nuclear quality assurance standard, the NQA-1, to research and development work. 1 fig., 7 tabs.

  6. Função respiratória em filhos de mães asmáticas

    Directory of Open Access Journals (Sweden)

    Marco A. Valadares

    2013-04-01

    Full Text Available OBJETIVO: Avaliar a função pulmonar e as manifestações clínicas sugestivas de asma em filhos de mães com diagnóstico médico referido de asma. MÉTODOS: Estudo observacional transversal analítico aninhado a uma coorte de 4.757 parturientes. Foram avaliadas 86 crianças aos seis anos de idade, filhas de mães com diagnóstico médico de asma antes da gestação. Foram coletadas informações referentes a sintomatologias clínicas de atopias e doenças respiratórias, variáveis socioeconômicas e de exposição; tendo sido as crianças submetidas à espirometria. RESULTADOS: Foram encontrados 30,3% de alterações espirométricas, havendo predomínio do diagnóstico de asma nos que apresentaram padrão obstrutivo. Diagnóstico médico pregresso de asma ocorreu em 9,3% das crianças; contudo, o diagnóstico estabelecido a partir da presença e frequência dos sintomas de asma representou 18,6%. Das 86 crianças participantes, 37,2% tiveram um escore de cinco ou mais pontos no questionário ISAAC, estando isso associado à alteração do padrão espirométrico (p = 0,002. Após a regressão logística múltipla, maior escolaridade paterna, maior número de quartos no domicílio e o fato de a mãe não ter apresentado "chiado" durante a gestação foram estatisticamente significantes como fatores protetores para a presença de distúrbio ventilatório à espirometria. CONCLUSÕES: A frequência de alterações do teste espirométrico em filhos de mães asmáticas foi alta, com o padrão restritivo ocorrendo mais vezes que o obstrutivo. Houve uma maior ocorrência de exames obstrutivos naqueles que apresentavam sintomatologia clínica de asma, com uma frequência de diagnóstico clínico de asma superior à encontrada na literatura.

  7. The effectiveness of fish oil supplementation in asthmatic rats is limited by an inefficient action on ASM function.

    Science.gov (United States)

    Miranda, D T S Z; Zanatta, A L; Dias, B C L; Fogaça, R T H; Maurer, J B B; Donatti, L; Calder, P C; Nishiyama, A

    2013-09-01

    Episodes of acute exacerbation are the major clinical feature of asthma and therefore represent an important focus for developing novel therapies for this disease. There are many reports that the n-3 fatty acids found in fish oil exert anti-inflammatory effects, but there are few studies of the action of fish oil on airway smooth muscle (ASM) function. In the present investigation, we evaluated the effect of fish oil supplementation on smooth muscle force of contraction in ovalbumin-induced asthmatic Wistar rats, and its consequences on static lung compliance, mucus production, leukocyte chemotaxis and production of proinflammatory cytokines. Fish oil supplementation suppressed the infiltration of inflammatory cells into the lung in asthmatic animals (2.04 ± 0.19 × 10(6) cells vs. 3.33 ± 0.43 × 10(6) cells in the control asthmatic group; P < 0.05). Static lung compliance increased with fish oil supplementation in asthmatic rats (0.640 ± 0.053 mL/cm H2O vs. 0.399 ± 0.043 mL/cm H2O; P < 0.05). However, fish oil did not prevent asthma-associated lung eosinophilia and did not affect the concentrations of tumor necrosis factor-α and interleukin-1β in lung tissue or the proportion of the airways obliterated with mucus. Fish oil had no effect on the force of contraction in asthmatic rats in response to acetylcholine (3.026 ± 0.274 mN vs. 2.813 ± 0.364 mN in the control asthmatic group). In conclusion, although fish oil exerts some benefits in this model of asthma, its effectiveness appears to be limited by an inefficient action on airway smooth muscle function.

  8. Nuclear Chemistry Division annual report FY83

    International Nuclear Information System (INIS)

    Struble, G.

    1983-01-01

    The purpose of the annual reports of the Nuclear Chemistry Division is to provide a timely summary of research activities pursued by members of the Division during the preceding year. Throughout, details are kept to a minimum; readers desiring additional information are encouraged to read the referenced documents or contact the authors. The Introduction presents an overview of the Division's scientific and technical programs. Next is a section of short articles describing recent upgrades of the Division's major facilities, followed by sections highlighting scientific and technical advances. These are grouped under the following sections: nuclear explosives diagnostics; geochemistry and environmental sciences; safeguards technology and radiation effect; and supporting fundamental science. A brief overview introduces each section. Reports on research supported by a particular program are generally grouped together in the same section. The last section lists the scientific, administrative, and technical staff in the Division, along with visitors, consultants, and postdoctoral fellows. It also contains a list of recent publications and presentations. Some contributions to the annual report are classified and only their abstracts are included in this unclassified portion of the report (UCAR-10062-83/1); the full article appears in the classified portion (UCAR-10062-83/2)

  9. Fuel Chemistry Division: progress report for 1985

    International Nuclear Information System (INIS)

    1988-01-01

    Fuel Chemistry Division was formed in May 1985 to give a larger emphasis on the research and development in chemistry of the nuclear fuel cycle. The areas of research in Fuel Chemistry Division are fuel development and its chemical quality control, understanding of the fuel behaviour and post irradiation examinations, chemistry of reprocessing and waste management processes as also the basic aspects of actinide and relevant fission product elements. This report summarises the work by the staff of the Division during 1985 and also some work from the previous periods which was not reported in the progress reports of the Radiochemistry Division. The work related to the FBTR fuel was one of the highlights during this period. In the area of process chemistry useful work has been carried out for processing of plutonium bearing solutions. In the area of mass spectrometry, the determination of trace constituents by spark source mass spectrometry has been a major area of research. Significant progress has also been made in the use of alpha spectromet ry techniques for the determination of plutonium in dissolver solution and other samples. The technology of plutonium utilisation is quite complex and the Division would continue to look into the chemical aspects of this technology and provide the necessary base for future developments in this area. (author)

  10. Nuclear Chemistry Division annual report FY83

    Energy Technology Data Exchange (ETDEWEB)

    Struble, G. (ed.)

    1983-01-01

    The purpose of the annual reports of the Nuclear Chemistry Division is to provide a timely summary of research activities pursued by members of the Division during the preceding year. Throughout, details are kept to a minimum; readers desiring additional information are encouraged to read the referenced documents or contact the authors. The Introduction presents an overview of the Division's scientific and technical programs. Next is a section of short articles describing recent upgrades of the Division's major facilities, followed by sections highlighting scientific and technical advances. These are grouped under the following sections: nuclear explosives diagnostics; geochemistry and environmental sciences; safeguards technology and radiation effect; and supporting fundamental science. A brief overview introduces each section. Reports on research supported by a particular program are generally grouped together in the same section. The last section lists the scientific, administrative, and technical staff in the Division, along with visitors, consultants, and postdoctoral fellows. It also contains a list of recent publications and presentations. Some contributions to the annual report are classified and only their abstracts are included in this unclassified portion of the report (UCAR-10062-83/1); the full article appears in the classified portion (UCAR-10062-83/2).

  11. Energy Technology Division research summary -- 1994

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    Research funded primarily by the NRC is directed toward assessing the roles of cyclic fatigue, intergranular stress corrosion cracking, and irradiation-assisted stress corrosion cracking on failures in light water reactor (LWR) piping systems, pressure vessels, and various core components. In support of the fast reactor program, the Division has responsibility for fuel-performance modeling and irradiation testing. The Division has major responsibilities in several design areas of the proposed International Thermonuclear Experimental Reactor (ITER). The Division supports the DOE in ensuring safe shipment of nuclear materials by providing extensive review of the Safety Analysis Reports for Packaging (SARPs). Finally, in the nuclear area they are investigating the safe disposal of spent fuel and waste. In work funded by DOE`s Energy Efficiency and Renewable Energy, the high-temperature superconductivity program continues to be a major focal point for industrial interactions. Coatings and lubricants developed in the division`s Tribology Section are intended for use in transportation systems of the future. Continuous fiber ceramic composites are being developed for high-performance heat engines. Nondestructive testing techniques are being developed to evaluate fiber distribution and to detect flaws. A wide variety of coatings for corrosion protection of metal alloys are being studied. These can increase lifetimes significant in a wide variety of coal combustion and gasification environments.

  12. Analytical Chemistry Division : annual report (for) 1985

    International Nuclear Information System (INIS)

    Mahadevan, N.

    1986-01-01

    An account of the various activities of the Analytical Chemistry Division of the Bhabha Atomic Research Centre, Bombay, during 1985 is presented. The main function of the Division is to provide chemical analysis support to India's atomic energy programme. In addition, the Division also offers its analytical services, mostly for measurement of concentrations at trace levels to Indian industries and other research organization in the country. A list of these determinations is given. The report also describes the research and development (R and D) activities - both completed and in progress, in the form of individual summaries. During the year an ultra trace analytical laboratory for analysis of critical samples without contamination was set up using indigenous material and technology. Publications and training activities of the staff, training of the staff from other institution, guidance by the staff for post-graduate degree and invited talks by the staff are listed in the appendices at the end of the report. (M.G.B.)

  13. Meiotic Divisions: No Place for Gender Equality.

    Science.gov (United States)

    El Yakoubi, Warif; Wassmann, Katja

    2017-01-01

    In multicellular organisms the fusion of two gametes with a haploid set of chromosomes leads to the formation of the zygote, the first cell of the embryo. Accurate execution of the meiotic cell division to generate a female and a male gamete is required for the generation of healthy offspring harboring the correct number of chromosomes. Unfortunately, meiosis is error prone. This has severe consequences for fertility and under certain circumstances, health of the offspring. In humans, female meiosis is extremely error prone. In this chapter we will compare male and female meiosis in humans to illustrate why and at which frequency errors occur, and describe how this affects pregnancy outcome and health of the individual. We will first introduce key notions of cell division in meiosis and how they differ from mitosis, followed by a detailed description of the events that are prone to errors during the meiotic divisions.

  14. Radiochemistry Division annual progress report: 1988

    International Nuclear Information System (INIS)

    1990-01-01

    The report covers the research and development (R and D) work carried out by Radiochemistry Division, Bhabha Atomic Research Centre, Bombay during the period 1987-1988. The R and D work is reported in the form of individual summari es grouped under the headings: (1)Actinide Chemistry, (2)Nuclear Chemistry, and (3)Spectroscopy. Some of the highlights of the work are studies on : (a)solvent extraction and complexation behaviour of actinides, (b)helium ion induced fission of 238 U and 165 Ho and fission yield of 252 Cf(sf), (c)separation of rare earths from fission products, (d)positron annihilation spectroscopy of high Tc superconductors, and (e)EPR spectroscopy of high Tc superconductors. Radioanalytical services and radiation sources given to the other Divisions and Organisations are listed. A list of publications and symposia papers by scientists of the Division is also given. 45 figs., 49 tabs

  15. Chemical Technology Division annual technical report, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    CMT is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. It conducts R&D in 3 general areas: development of advanced power sources for stationary and transportation applications and for consumer electronics, management of high-level and low-level nuclear wastes and hazardous wastes, and electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, materials chemistry of electrified interfaces and molecular sieves, and the theory of materials properties. It also operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at ANL and other organizations. Technical highlights of the Division`s activities during 1996 are presented.

  16. Organization structure. Main activities of the Division

    International Nuclear Information System (INIS)

    2008-01-01

    In this chapter the organization structure as well as main activities of the Division for radiation safety, NPP decommissioning and radioactive waste management are presented. This Division of the VUJE, a.s. consists of the following sections and departments: Section for economic and technical services; Section for radiation protection of employees; Department for management of emergency situations and risk assessment; Department for implementation of nuclear power facilities decommissioning and RAW management; Department for personnel and environmental dosimetry; Department for preparation of NPP decommissioning; Department for RAW treatment technologies; Department for chemical regimes and physico-chemical analyses; Department for management of nuclear power facilities decommissioning and RAW management. Main activities of this Division are presented.

  17. Biology Division progress report, October 1, 1991--September 30, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Hartman, F.C.; Cook, J.S.

    1993-10-01

    This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1991, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report.

  18. Parkin suppresses Drp1-independent mitochondrial division

    International Nuclear Information System (INIS)

    Roy, Madhuparna; Itoh, Kie; Iijima, Miho; Sesaki, Hiromi

    2016-01-01

    The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much Drp1-mediated mitochondrial division accounts for the connectivity of mitochondria. The role of a Parkinson’s disease-associated protein—parkin, which biochemically and genetically interacts with Drp1—in mitochondrial connectivity also remains poorly understood. Here, we quantified the number and connectivity of mitochondria using mitochondria-targeted photoactivatable GFP in cells. We show that the loss of Drp1 increases the connectivity of mitochondria by 15-fold in mouse embryonic fibroblasts (MEFs). While a single loss of parkin does not affect the connectivity of mitochondria, the connectivity of mitochondria significantly decreased compared with a single loss of Drp1 when parkin was lost in the absence of Drp1. Furthermore, the loss of parkin decreased the frequency of depolarization of the mitochondrial inner membrane that is caused by increased mitochondrial connectivity in Drp1-knockout MEFs. Therefore, our data suggest that parkin negatively regulates Drp1-indendent mitochondrial division. -- Highlights: •A Drp1-mediated mechanism accounts for ∼95% of mitochondrial division. •Parkin controls the connectivity of mitochondria via a mechanism that is independent of Drp1. •In the absence of Drp1, connected mitochondria transiently depolarize. •The transient depolarization is independent of calcium signaling and uncoupling protein 2.

  19. Parkin suppresses Drp1-independent mitochondrial division

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Madhuparna, E-mail: mroy17@jhmi.edu; Itoh, Kie, E-mail: kito5@jhmi.edu; Iijima, Miho, E-mail: miijima@jhmi.edu; Sesaki, Hiromi, E-mail: hsesaki@jhmi.edu

    2016-07-01

    The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much Drp1-mediated mitochondrial division accounts for the connectivity of mitochondria. The role of a Parkinson’s disease-associated protein—parkin, which biochemically and genetically interacts with Drp1—in mitochondrial connectivity also remains poorly understood. Here, we quantified the number and connectivity of mitochondria using mitochondria-targeted photoactivatable GFP in cells. We show that the loss of Drp1 increases the connectivity of mitochondria by 15-fold in mouse embryonic fibroblasts (MEFs). While a single loss of parkin does not affect the connectivity of mitochondria, the connectivity of mitochondria significantly decreased compared with a single loss of Drp1 when parkin was lost in the absence of Drp1. Furthermore, the loss of parkin decreased the frequency of depolarization of the mitochondrial inner membrane that is caused by increased mitochondrial connectivity in Drp1-knockout MEFs. Therefore, our data suggest that parkin negatively regulates Drp1-indendent mitochondrial division. -- Highlights: •A Drp1-mediated mechanism accounts for ∼95% of mitochondrial division. •Parkin controls the connectivity of mitochondria via a mechanism that is independent of Drp1. •In the absence of Drp1, connected mitochondria transiently depolarize. •The transient depolarization is independent of calcium signaling and uncoupling protein 2.

  20. On-chip mode division multiplexing technologies

    DEFF Research Database (Denmark)

    Ding, Yunhong; Frellsen, Louise Floor; Guan, Xiaowei

    2016-01-01

    Space division multiplexing (SDM) is currently widely investigated in order to provide enhanced capacity thanks to the utilization of space as a new degree of multiplexing freedom in both optical fiber communication and on-chip interconnects. Basic components allowing the processing of spatial...... using one-dimensional (1D) photonic crystal silicon waveguides. We furthermore use the fabricated devices to demonstrate on-chip point-to-point mode division multiplexing transmission, and all-optical signal processing by mode-selective wavelength conversion. Finally, we report an efficient silicon...

  1. Life Sciences Division annual report, 1988

    International Nuclear Information System (INIS)

    Marrone, B.L.; Cram, L.S.

    1989-04-01

    This report summarizes the research and development activities of Los Alamos National Laboratory's Life Sciences Division for the calendar year 1988. Technical reports related to the current status of projects are presented in sufficient detail to permit the informed reader to assess their scope and significance. Summaries useful to the casual reader desiring general information have been prepared by the Group Leaders and appear in each group overview. Investigators on the staff of the Life Sciences Division will be pleased to provide further information

  2. Quantum internet using code division multiple access

    Science.gov (United States)

    Zhang, Jing; Liu, Yu-xi; Özdemir, Şahin Kaya; Wu, Re-Bing; Gao, Feifei; Wang, Xiang-Bin; Yang, Lan; Nori, Franco

    2013-01-01

    A crucial open problem inS large-scale quantum networks is how to efficiently transmit quantum data among many pairs of users via a common data-transmission medium. We propose a solution by developing a quantum code division multiple access (q-CDMA) approach in which quantum information is chaotically encoded to spread its spectral content, and then decoded via chaos synchronization to separate different sender-receiver pairs. In comparison to other existing approaches, such as frequency division multiple access (FDMA), the proposed q-CDMA can greatly increase the information rates per channel used, especially for very noisy quantum channels. PMID:23860488

  3. Life Sciences Division annual report, 1988

    Energy Technology Data Exchange (ETDEWEB)

    Marrone, B.L.; Cram, L.S. (comps.)

    1989-04-01

    This report summarizes the research and development activities of Los Alamos National Laboratory's Life Sciences Division for the calendar year 1988. Technical reports related to the current status of projects are presented in sufficient detail to permit the informed reader to assess their scope and significance. Summaries useful to the casual reader desiring general information have been prepared by the Group Leaders and appear in each group overview. Investigators on the staff of the Life Sciences Division will be pleased to provide further information.

  4. Nuclear Physics Division: annual report 1991

    International Nuclear Information System (INIS)

    Betigeri, M.G.

    1993-01-01

    A brief account of the research and development activities carried out by the Nuclear Physics Division, Bhabha Atomic Research Centre, Bombay during the period January 1991 to December 1991 is presented. These R and D activities are reported under the headings : 1) Accelerator Facilities, 2) Research Activities, and 3) Instrumentation. At the end, a list of publications by the staff scientists of the Division is given. The list includes papers published in journals, papers presented at conferences, symposia etc., and technical reports. (author). figs., tabs

  5. TRIUMF: Technology transfer

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    In our occasional series highlighting the increasingly important area of technology transfer and industrial spinoff from high energy physics, this month the CERN Courier focuses on TRIUMF in Vancouver, Canada's major national facility for research in subatomic physics, a particularly illustrative example of the rewards and challenges involved. TRIUMF is based on a 520 MeV negative hydrogen ion cyclotron meson factory operated by a consortium of Canadian universities. Although the primary funding from the Canadian government is earmarked for support of basic research, the laboratory has always fostered applications of the technologies available, supporting them with funds from other sources. At first this ''applied programme'' involved simply the provision of particle beams for other scientific, medical and industrial uses - protons for the development of neutrondeficient radioisotopes, neutrons for activation analysis, pions for cancer therapy, and muons for chemistry and condensed-matter physics. Twenty five years on, the technology transfer process has resulted not only in a significantly expanded internal applied programme, with many areas of activity quite independent of the big cyclotron, but also in a number of successful commercial operations in the Vancouver area. Radioisotope production has been a particularly fruitful source for technology transfer, the early development work leading to two important initiatives - the establishment of a commercial radioisotope production facility on site and the inauguration of a positron emission tomography (PET) program at the University of British Columbia nearby. In 1979 Atomic Energy of Canada Ltd's isotope production division (now Nordion International Inc.) decided to establish a western Canadian facility at TRIUMF, to produce the increasingly important neutron-deficient radioisotopes obtainable with accelerator beams, primarily for medical applications. This would complement their

  6. Exercise-induced Bronchospasm In Obese And Non-obese Asthmatic Adolescents [broncoespasmo Induzido Pelo Exercício Em Adolescentes Asmáticos Obesos E Não-obesos

    OpenAIRE

    Lopes W.A.; Leite N.; Rosario N.

    2010-01-01

    OBJETIVO: Avaliar e comparar a frequência e intensidade do broncoespasmo induzido pelo exercício (BIE) em adolescentes asmáticos obesos e não-obesos. MÉTODOS: Estudo transversal e descritivo realizado com 39 adolescentes de ambos os sexos, com idade entre dez e 16 anos, divididos em dois grupos conforme o histórico clínico de asma e/ou rinite alérgica e o índice de massa corporal: asmáticos obesos (n=18); asmáticos não-obesos (n=21). Utilizou-se o teste de broncoprovocação com exercício para ...

  7. Assessment of crack-like flaws - Comparison of procedures in BS 7910, API 579-1/ASME FFS-1, RSE-M AND FITNET

    International Nuclear Information System (INIS)

    Chaudouet, A.

    2007-01-01

    Among all Fitness For Service Codes enabling to assess flaws in metallic structures and to evaluate their remaining life, new editions of the most important ones at the international level have been issued recently. The latest edition of BS 7910 in United Kingdom has been released in October 2005. In the USA, API and ASME have edited a new standard in 2007, API579-1/ASME FFS-1, dedicated to pressure equipment. In France, the rules concerning the of Light Water Reactors, RSE-M, have been updated in 2005. Finally, in Europe, the FITNET network is writing a document based on BS 7910 but extended with the most recent results in this domain. Rules given in these documents to assess crack-like flaws with respect to fracture and fatigue propagation are presented. They are compared in order to point out the most interesting aspects of each ones and to identify those which could be generalized. An example assessed with the above mentioned 'Codes' enlightens the differences in the results with respect to the 'Code' used. (author) [fr

  8. Technology Transfer

    Science.gov (United States)

    Smith, Nanette R.

    1995-01-01

    The objective of this summer's work was to attempt to enhance Technology Application Group (TAG) ability to measure the outcomes of its efforts to transfer NASA technology. By reviewing existing literature, by explaining the economic principles involved in evaluating the economic impact of technology transfer, and by investigating the LaRC processes our William & Mary team has been able to lead this important discussion. In reviewing the existing literature, we identified many of the metrics that are currently being used in the area of technology transfer. Learning about the LaRC technology transfer processes and the metrics currently used to track the transfer process enabled us to compare other R&D facilities to LaRC. We discuss and diagram impacts of technology transfer in the short run and the long run. Significantly, it serves as the basis for analysis and provides guidance in thinking about what the measurement objectives ought to be. By focusing on the SBIR Program, valuable information regarding the strengths and weaknesses of this LaRC program are to be gained. A survey was developed to ask probing questions regarding SBIR contractors' experience with the program. Specifically we are interested in finding out whether the SBIR Program is accomplishing its mission, if the SBIR companies are providing the needed innovations specified by NASA and to what extent those innovations have led to commercial success. We also developed a survey to ask COTR's, who are NASA employees acting as technical advisors to the SBIR contractors, the same type of questions, evaluating the successes and problems with the SBIR Program as they see it. This survey was developed to be implemented interactively on computer. It is our hope that the statistical and econometric studies that can be done on the data collected from all of these sources will provide insight regarding the direction to take in developing systematic evaluations of programs like the SBIR Program so that they can

  9. Radiochemistry Division annual progress report for 1977

    International Nuclear Information System (INIS)

    Iyer, R.H.; Natarajan, P.R.

    1979-01-01

    The research and development work carried by the Radiochemistry Division of the Bhabha Atomic Research Centre, Bombay, during the calendar year 1977 in the areas of reactor chemistry, actinide chemistry, process chemistry of neptunium and plutonium-239, radioanalytical chemistry and nuclear chemistry has been reported. (M.G.B.)

  10. 2018 News Articles | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  11. 2013 News Articles | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  12. 2014 News Articles | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  13. Administrative Resource Center | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  14. Earth Sciences Division annual report, 1976

    International Nuclear Information System (INIS)

    Hornady, B.; Duba, A.

    1977-01-01

    This compilation lists abstracts of papers, internal reports, and talks presented during 1976 at national and international meetings by members of the Earth Sciences Division, Lawrence Livermore Laboratory. Subjects include: coal gasification, gas stimulation, geothermal fields, oil shale retorting, radioactive waste management, geochemistry, geophysics, seismology, explosive phenomenology, and miscellaneous studies

  15. Easy come-easy go divisible cash

    Energy Technology Data Exchange (ETDEWEB)

    Chan, A.; Tsiounis, Y. [Northeastern Univ., Boston, MA (United States). Coll. of Computer Science; Frankel, Y. [Sandia National Labs., Albuquerque, NM (United States)

    1996-10-16

    Recently, there has been an interest in making electronic cash protocols more practical for electronic commerce by developing e-cash which is divisible (e.g., a coin which can be spent incrementally but total purchases are limited to the monetary value of the coin). In Crypto`95, T. Okamoto presented the first practical divisible, untraceable, off-line e-cash scheme, which requires only O(log N) computations for each of the withdrawal, payment and deposit procedures, where N = (total coin value)/(smallest divisible unit). However, Okamoto`s set-up procedure is quite inefficient (on the order of 4,000 multi-exponentiations and depending on the size of the RSA modulus). The authors formalize the notion of range-bounded commitment, originally used in Okamoto`s account establishment protocol, and present a very efficient instantiation which allows one to construct the first truly efficient divisible e-cash system. The scheme only requires the equivalent of one (1) exponentiation for set-up, less than 2 exponentiations for withdrawal and around 20 for payment, while the size of the coin remains about 300 Bytes. Hence, the withdrawal protocol is 3 orders of magnitude faster than Okamoto`s, while the rest of the system remains equally efficient, allowing for implementation in smart-cards. Similar to Okamoto`s, the scheme is based on proofs whose cryptographic security assumptions are theoretically clarified.

  16. Sarah Temkin, MD | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  17. Materials Sciences Division 1990 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    This report is the Materials Sciences Division's annual report. It contains abstracts describing materials research at the National Center for Electron Microscopy, and for research groups in metallurgy, solid-state physics, materials chemistry, electrochemical energy storage, electronic materials, surface science and catalysis, ceramic science, high tc superconductivity, polymers, composites, and high performance metals.

  18. Theoretical Division annual report, FY 1975. [LASL

    Energy Technology Data Exchange (ETDEWEB)

    Carruthers, P.A.

    1976-02-01

    This report presents an overview of the activities in the Theoretical Division and a summary of research highlights during FY 1975. It is intended to inform a wide audience about the theoretical work of the LASL and, therefore, contains introductory material which places recent advances in a broader context. The report is organized into two special interest reports: reactor safety research and the Advanced Research Committee, and 11 reports from the T-Division group leaders on the work of their respective groups. Main interests and responsibilities are outlined including the relationship of the group's work to the work of other T-Division groups and other divisions at the Laboratory. The description of research highlights for FY 1975 explains in a fairly simple, straightforward manner the major recent advances and their significance. Each group report is followed by a publication list for FY 1975 (330 references) and a list of talks given outside the Laboratory (140 references). 29 figures. (auth)

  19. Budget Setting Strategies for the Company's Divisions

    NARCIS (Netherlands)

    Berg, M.; Brekelmans, R.C.M.; De Waegenaere, A.M.B.

    1997-01-01

    The paper deals with the issue of budget setting to the divisions of a company. The approach is quantitative in nature both in the formulation of the requirements for the set-budgets, as related to different general managerial objectives of interest, and in the modelling of the inherent

  20. Research Award: CommunicaƟons Division

    International Development Research Centre (IDRC) Digital Library (Canada)

    Corey Piccioni

    As a member of the Division's team, you will also contribute for half a year to a variety of other communicaon tasks. Your research proposal should address one or more aspects of successful communicaon. For example: • How can the outcomes and impacts of communicaon iniaves be measured (branding, website, media.

  1. Nutritional Science Staff | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  2. Physics Division activities report, 1986--1987

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    This report summarizes the research activities of the Physics Division for the years 1986 and 1987. Areas of research discussed in this paper are: research on e/sup +/e/sup /minus// interactions; research on p/bar p/ interactions; experiment at TRIUMF; double beta decay; high energy astrophysics; interdisciplinary research; and advanced technology development and the SSC.

  3. Earth Sciences Division annual report 1990

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-06-01

    This Annual Report presents summaries of selected representative research activities grouped according to the principal disciplines of the Earth Sciences Division: Reservoir Engineering and Hydrogeology, Geology and Geochemistry, and Geophysics and Geomechanics. Much of the Division`s research deals with the physical and chemical properties and processes in the earth`s crust, from the partially saturated, low-temperature near-surface environment to the high-temperature environments characteristic of regions where magmatic-hydrothermal processes are active. Strengths in laboratory and field instrumentation, numerical modeling, and in situ measurement allow study of the transport of mass and heat through geologic media -- studies that now include the appropriate chemical reactions and the hydraulic-mechanical complexities of fractured rock systems. Of particular note are three major Division efforts addressing problems in the discovery and recovery of petroleum, the application of isotope geochemistry to the study of geodynamic processes and earth history, and the development of borehole methods for high-resolution imaging of the subsurface using seismic and electromagnetic waves. In 1989 a major DOE-wide effort was launched in the areas of Environmental Restoration and Waste Management. Many of the methods previously developed for and applied to deeper regions of the earth will in the coming years be turned toward process definition and characterization of the very shallow subsurface, where man-induced contaminants now intrude and where remedial action is required.

  4. Physics Division activities report, 1986--1987

    International Nuclear Information System (INIS)

    1987-01-01

    This report summarizes the research activities of the Physics Division for the years 1986 and 1987. Areas of research discussed in this paper are: research on e + e/sup /minus// interactions; research on p/bar p/ interactions; experiment at TRIUMF; double beta decay; high energy astrophysics; interdisciplinary research; and advanced technology development and the SSC

  5. Research Award: Donor Partnership Division | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-09-07

    Sep 7, 2016 ... IDRC's Donor Partnerships division (DPD) initiates, builds, and maintains relationships with donors, international organizations, and research funders ... We are particularly interested in research related to public-private partnerships for development, bilateral investments in research, trends in private ...

  6. Materials Sciences Division 1990 annual report

    International Nuclear Information System (INIS)

    1990-01-01

    This report is the Materials Sciences Division's annual report. It contains abstracts describing materials research at the National Center for Electron Microscopy, and for research groups in metallurgy, solid-state physics, materials chemistry, electrochemical energy storage, electronic materials, surface science and catalysis, ceramic science, high tc superconductivity, polymers, composites, and high performance metals

  7. Energy Technology Division research summary -- 1994

    International Nuclear Information System (INIS)

    1994-09-01

    Research funded primarily by the NRC is directed toward assessing the roles of cyclic fatigue, intergranular stress corrosion cracking, and irradiation-assisted stress corrosion cracking on failures in light water reactor (LWR) piping systems, pressure vessels, and various core components. In support of the fast reactor program, the Division has responsibility for fuel-performance modeling and irradiation testing. The Division has major responsibilities in several design areas of the proposed International Thermonuclear Experimental Reactor (ITER). The Division supports the DOE in ensuring safe shipment of nuclear materials by providing extensive review of the Safety Analysis Reports for Packaging (SARPs). Finally, in the nuclear area they are investigating the safe disposal of spent fuel and waste. In work funded by DOE's Energy Efficiency and Renewable Energy, the high-temperature superconductivity program continues to be a major focal point for industrial interactions. Coatings and lubricants developed in the division's Tribology Section are intended for use in transportation systems of the future. Continuous fiber ceramic composites are being developed for high-performance heat engines. Nondestructive testing techniques are being developed to evaluate fiber distribution and to detect flaws. A wide variety of coatings for corrosion protection of metal alloys are being studied. These can increase lifetimes significant in a wide variety of coal combustion and gasification environments

  8. Study of the Division of Allied Health.

    Science.gov (United States)

    Perelle, Ira B.

    This study examines student outcomes in the seven curriculum programs (chemical technology, dental hygiene, dental laboratory, medical laboratory, nursing, opthalmic dispensing, and radiologic technology) of the Division of Allied Health and Natural Sciences at New York City Community College. The following variables are examined: student…

  9. Problems on Divisibility of Binomial Coefficients

    Science.gov (United States)

    Osler, Thomas J.; Smoak, James

    2004-01-01

    Twelve unusual problems involving divisibility of the binomial coefficients are represented in this article. The problems are listed in "The Problems" section. All twelve problems have short solutions which are listed in "The Solutions" section. These problems could be assigned to students in any course in which the binomial theorem and Pascal's…

  10. Wavelet based multicarrier code division multiple access ...

    African Journals Online (AJOL)

    This paper presents the study on Wavelet transform based Multicarrier Code Division Multiple Access (MC-CDMA) system for a downlink wireless channel. The performance of the system is studied for Additive White Gaussian Noise Channel (AWGN) and slowly varying multipath channels. The bit error rate (BER) versus ...

  11. Selected Publications of the Division of Nursing.

    Science.gov (United States)

    Public Health Service (DHEW), Arlington, VA. Div. of Nursing.

    Publications are organized under the following topics: (1) Division of Nursing Program, (2) Nurse Training Act of 1964, (3) Nursing (general interest), (4) Nursing Manpower, (5) Nursing Services in Hospitals, (6) Public Health Nursing, (7) Nursing Education, (8) Nursing Research and Research Training, and (9) Nurse Training Manuals. Single copies…

  12. Ontario Hydro Research Division annual report 1988

    International Nuclear Information System (INIS)

    1988-01-01

    The Research Division of Ontario Hydro conducts research in the fields of chemistry, civil engineering, electrical engineering, mechanical engineering, metallurgy, and operations. Much of the research has a bearing on the safe, environmentally benign operation of Ontario Hydro's nuclear power plants. Particular emphasis has been placed on nuclear plant component aging and plant life assurance

  13. Genes involved in cell division in mycoplasmas

    Directory of Open Access Journals (Sweden)

    Frank Alarcón

    2007-01-01

    Full Text Available Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important to compare their genomes to analyze putative genes involved in cell division processes. The division and cell wall (dcw cluster, which in E. coli and B. subtilis is composed of 16 and 17 genes, respectively, is represented by only three to four genes in mycoplasmas. Even the most conserved protein, FtsZ, is not present in all mycoplasma genomes analyzed so far. A model for the FtsZ protein from Mycoplasma hyopneumoniae and Mycoplasma synoviae has been constructed. The conserved residues, essential for GTP/GDP binding, are present in FtsZ from both species. A strong conservation of hydrophobic amino acid patterns is observed, and is probably necessary for the structural stability of the protein when active. M. synoviae FtsZ presents an extended amino acid sequence at the C-terminal portion of the protein, which may participate in interactions with other still unknown proteins crucial for the cell division process.

  14. Declassification and divisiveness in human services.

    Science.gov (United States)

    Tambor, M

    1983-01-01

    The issue of declassification can be used to promote divisions between professional social workers and other human service workers. The author examines the experience of declassification and Benchmark in the Michigan Human Services Employment Unit. Collective bargaining is suggested as a means for both addressing social work education qualifications and career ladders for human service workers.

  15. Quality assurance plan, Westinghouse Water Reactor Divisions

    Energy Technology Data Exchange (ETDEWEB)

    1976-03-01

    The Quality Assurance Program used by Westinghouse Nuclear Energy Systems Water Reactor Divisions is described. The purpose of the program is to assure that the design, materials, and workmanship on Nuclear Steam Supply System (NSSS) equipment meet applicable safety requirements, fulfill the requirements of the contracts with the applicants, and satisfy the applicable codes, standards, and regulatory requirements.

  16. Chemical Biodynamics Division. Annual report 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    The Chemical Biodynamics Division of LBL continues to conduct basic research on the dynamics of living cells and on the interaction of radiant energy with organic matter. Many aspects of this basic research are related to problems of environmental and health effects of fossil fuel combustion, solar energy conversion and chemical/ viral carcinogenesis.

  17. Operational momentum in multiplication and division?

    Science.gov (United States)

    Katz, Curren; Knops, André

    2014-01-01

    Biases are commonly seen in numerical cognition. The operational momentum (OM) effect shows that responses to addition and subtraction problems are biased in the whole-number direction of the operation. It is not known if this bias exists for other arithmetic operations. To determine whether OM exists in scalar operations, we measured response bias in adults performing symbolic (Arabic digits) and non-symbolic (dots) multiplication and division problems. After seeing two operands, with either a multiplication (×) or division (÷) sign, participants chose among five response choices. Both non-random performance profiles and the significant contribution of both operands in a multiple regression analysis predicting the chosen values, suggest that adults were able to use numerical information to approximate the outcomes in both notations, though they were more accurate on symbolic problems. Performance on non-symbolic problems was influenced by the size of the correct choice relative to alternatives. Reminiscent of the bias in addition and subtraction, we found a significant response bias for non-symbolic problems. Non-symbolic multiplication problems were overestimated and division problems were underestimated. These results indicate that operational momentum is present in non-symbolic multiplication and division. Given the influence of the size of the correct choice relative to alternatives, an interaction between heuristic bias and approximate calculation is possible.

  18. Technology transfer

    International Nuclear Information System (INIS)

    Boury, C.

    1986-01-01

    This paper emphasizes in the specific areas of design, engineering and component production. This paper presents what Framatome has to offer in these areas and its export oriented philosophy. Then, a typical example of this technology transfer philosophy is the collaboration with the South Korean firm, Korea Heavy Industries Corporation (KHIC) for the supply of KNU 9 and KNU 10 power stations

  19. Experimental characterization and modeling of the creep strength at 550 C of ASME Grade 92 steel welded joints

    International Nuclear Information System (INIS)

    Kalck, Ch.

    2012-01-01

    In the framework of the development of Generation IV nuclear power plants, ASME Grade 92 ferritic-martensitic steel is a candidate material for components subjected to long-term creep at high temperature. The aim of this study is to characterize the microstructure of Grade 92 butt welded joints and to model their creep behavior at 550 C. Two filler rods were used for this study. The microstructure of the different weld regions was quantitatively characterized. In order to understand the weaker mechanical properties of the ICHAZ compared to the other regions of the welded joint, the microstructures of the base metal and the ICHAZ were compared at different scales (SEM, EBSD, TEM on thin foils and extractive replicas). No significant difference regarding micro-texture, sub-structure and precipitation state was highlighted between both microstructures. The origin of the weaker resistance of the ICHAZ to viscoplastic flow is still not fully understood. A softer zone was found in the base metal close to the ICHAZ, yet with finer sub-grains than the base metal. It was supposed to be a thermo-mechanically-affected zone (TMAZ). At high temperatures and low stress levels, Grade 92 welded joints may be sensitive to type IV cracking, which occurs in the inter-critical heat affected zone (ICHAZ). Creep tests conducted at 550 C on cross-weld specimens revealed that fracture takes place in the ICHAZ, even for short-term creep tests (i.e., lifetime lower than 1000 h). In order to model the creep behavior of the welded joint, viscoplastic constitutive equations for the different regions of the weld assembly were required. The viscoplastic behavior of the base metal, weld metal and of the ICHAZ were modeled using a phenomenological approach. The viscoplastic flow behavior of the weld metal and of the ICHAZ was experimentally determined (i) from tensile tests with displacement field measurements and (ii) from creep tests on tensile bars notched in the region of interest. An

  20. Energy Technology Division research summary 1997.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-21

    The Energy Technology Division provides materials and engineering technology support to a wide range of programs important to the US Department of Energy. As shown on the preceding page, the Division is organized into ten sections, five with concentrations in the materials area and five in engineering technology. Materials expertise includes fabrication, mechanical properties, corrosion, friction and lubrication, and irradiation effects. Our major engineering strengths are in heat and mass flow, sensors and instrumentation, nondestructive testing, transportation, and electromechanics and superconductivity applications. The Division Safety Coordinator, Environmental Compliance Officers, Quality Assurance Representative, Financial Administrator, and Communication Coordinator report directly to the Division Director. The Division Director is personally responsible for cultural diversity and is a member of the Laboratory-wide Cultural Diversity Advisory Committee. The Division's capabilities are generally applied to issues associated with energy production, transportation, utilization or conservation, or with environmental issues linked to energy. As shown in the organization chart on the next page, the Division reports administratively to the Associate Laboratory Director (ALD) for Energy and Environmental Science and Technology (EEST) through the General Manager for Environmental and Industrial Technologies. While most of our programs are under the purview of the EEST ALD, we also have had programs funded under every one of the ALDs. Some of our research in superconductivity is funded through the Physical Research Program ALD. We also continue to work on a number of nuclear-energy-related programs under the ALD for Engineering Research. Detailed descriptions of our programs on a section-by-section basis are provided in the remainder of this book. This Overview highlights some major trends. Research related to the operational safety of commercial light water

  1. Energy Technology Division research summary 1997

    International Nuclear Information System (INIS)

    1997-01-01

    The Energy Technology Division provides materials and engineering technology support to a wide range of programs important to the US Department of Energy. As shown on the preceding page, the Division is organized into ten sections, five with concentrations in the materials area and five in engineering technology. Materials expertise includes fabrication, mechanical properties, corrosion, friction and lubrication, and irradiation effects. Our major engineering strengths are in heat and mass flow, sensors and instrumentation, nondestructive testing, transportation, and electromechanics and superconductivity applications. The Division Safety Coordinator, Environmental Compliance Officers, Quality Assurance Representative, Financial Administrator, and Communication Coordinator report directly to the Division Director. The Division Director is personally responsible for cultural diversity and is a member of the Laboratory-wide Cultural Diversity Advisory Committee. The Division's capabilities are generally applied to issues associated with energy production, transportation, utilization or conservation, or with environmental issues linked to energy. As shown in the organization chart on the next page, the Division reports administratively to the Associate Laboratory Director (ALD) for Energy and Environmental Science and Technology (EEST) through the General Manager for Environmental and Industrial Technologies. While most of our programs are under the purview of the EEST ALD, we also have had programs funded under every one of the ALDs. Some of our research in superconductivity is funded through the Physical Research Program ALD. We also continue to work on a number of nuclear-energy-related programs under the ALD for Engineering Research. Detailed descriptions of our programs on a section-by-section basis are provided in the remainder of this book. This Overview highlights some major trends. Research related to the operational safety of commercial light water nuclear

  2. Optical Code-Division Multiple-Access and Wavelength Division Multiplexing: Hybrid Scheme Review

    OpenAIRE

    P. Susthitha Menon; Sahbudin Shaari; Isaac A.M. Ashour; Hesham A. Bakarman

    2012-01-01

    Problem statement: Hybrid Optical Code-Division Multiple-Access (OCDMA) and Wavelength-Division Multiplexing (WDM) have flourished as successful schemes for expanding the transmission capacity as well as enhancing the security for OCDMA. However, a comprehensive review related to this hybrid system are lacking currently. Approach: The purpose of this paper is to review the literature on OCDMA-WDM overlay systems, including our hybrid approach of one-dimensional coding of SAC OCDMA with WDM si...

  3. Technology transfer

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    Illustrated by the example of the FRG's nuclear energy exports, it is shown that the nuclear technology transfer leads to new dimensions of intergovernmental relations, which hold within themselves on account of multiple state-to-state, scientific, industrial and - last but not least - personal contacts the chance of far-reaching friendships between countries and people. If the chance is taken, this can also be seen as an important contribution towards maintaining the peace. (orig.) [de

  4. Anatomy Transfer

    OpenAIRE

    Dicko, Ali Hamadi; Liu, Tiantian; Gilles, Benjamin; Kavan, Ladislav; Faure, François; Palombi, Olivier; Cani, Marie-Paule

    2013-01-01

    International audience; Characters with precise internal anatomy are important in film and visual effects, as well as in medical applications. We propose the first semi-automatic method for creating anatomical structures, such as bones, muscles, viscera and fat tissues. This is done by transferring a reference anatomical model from an input template to an arbitrary target character, only defined by its boundary representation (skin). The fat distribution of the target character needs to be sp...

  5. Transfer Zymography.

    Science.gov (United States)

    Pan, Daniel; Wilson, Karl A; Tan-Wilson, Anna

    2017-01-01

    The technique described here, transfer zymography, was developed to overcome two limitations of conventional zymography. When proteolytic enzymes are resolved by nonreducing SDS-PAGE into a polyacrylamide gel with copolymerized protein substrate, the presence of the protein substrate can result in anomalous, often slower, migration of the protease and an estimated mass higher than its actual mass. A further drawback is that the presence of a high background of substrate protein interferes with proteomic analysis of the protease band by excision, tryptic digestion, and LC-MS/MS analysis. In transfer zymography, the proteolytic enzymes are resolved by conventional nonreducing SDS-PAGE, without protein substrate in the gel. The proteins in the resolving gel are then electrophoretically transferred to a receiving gel that contains the protein substrate, by a process similar to western blotting. The receiving gel is then processed in a manner similar to conventional zymography. SDS is removed by Triton X-100 and incubated in conditions suitable for the proteolytic activity. After protein staining, followed by destaining, bands representing regions with active protease are visualized as clear bands in a darkly stained background. For proteomic analysis, electrophoresis is carried out simultaneously on a second resolving gel, and the bands corresponding to the clear regions in the receiving gel after zymogram development are excised for proteomic analysis.

  6. DNR Division of Parks and Trails District Boundaries

    Data.gov (United States)

    Minnesota Department of Natural Resources — This data shows the DNR Division of Parks and Trails District Boundaries as of May 2010. The boundaries were created by the Division Leadership Team. Boundaries are...

  7. Engineering Research Division publication report, calendar year 1980

    Energy Technology Data Exchange (ETDEWEB)

    Miller, E.K.; Livingston, P.L.; Rae, D.C. (eds.)

    1980-06-01

    Each year the Engineering Research Division of the Electronics Engineering Department at Lawrence Livermore Laboratory has issued an internal report listing all formal publications produced by the Division during the calendar year. Abstracts of 1980 reports are presented.

  8. Engineering Research Division publication report, calendar year 1980

    International Nuclear Information System (INIS)

    Miller, E.K.; Livingston, P.L.; Rae, D.C.

    1980-06-01

    Each year the Engineering Research Division of the Electronics Engineering Department at Lawrence Livermore Laboratory has issued an internal report listing all formal publications produced by the Division during the calendar year. Abstracts of 1980 reports are presented

  9. Radiochemistry Division annual progress report : 1990

    International Nuclear Information System (INIS)

    Iyer, R.H.

    1992-01-01

    This progress report provides an account of the research and development activities of the Radiochemistry Division during the year 1990 in the areas of nuclear chemistry, actinide chemistry and spectroscopy. The main area of work in nuclear chemistry is centered around the fission process induced by reactor neutrons, and light and heavy ions on actinides and low Z (Z<80) elements. Actinide chemistry research is concerned mostly with extraction, complexation and separation of actinide ions from aqueous media using a variety of organic reagents under different experimental conditions. Spectroscopic studies include development and optimisation of chemical/analytical methods for separation and determination of trace metallic impurities and rare earths in fuel materials and EPR and microwave studies on several compounds to understand their superconducting, structural and magnetic properties. A list of publications by the scientific staff of the Division during 1990 is also given in the report. (author). 45 figs., 44 tabs

  10. Chemical Technology Division annual technical report, 1996

    International Nuclear Information System (INIS)

    1997-06-01

    CMT is a diverse technical organization with principal emphases in environmental management and development of advanced energy sources. It conducts R ampersand D in 3 general areas: development of advanced power sources for stationary and transportation applications and for consumer electronics, management of high-level and low-level nuclear wastes and hazardous wastes, and electrometallurgical treatment of spent nuclear fuel. The Division also performs basic research in catalytic chemistry involving molecular energy resources, mechanisms of ion transport in lithium battery electrolytes, materials chemistry of electrified interfaces and molecular sieves, and the theory of materials properties. It also operates the Analytical Chemistry Laboratory, which conducts research in analytical chemistry and provides analytical services for programs at ANL and other organizations. Technical highlights of the Division's activities during 1996 are presented

  11. Radiochemistry Division: annual progress report: 1987

    International Nuclear Information System (INIS)

    1989-01-01

    The progress of Research and Development (R and D) activities during the year 1987 are reported in the form of summaries, which are presented under the headings (1) Actinide Chemistry, (2) Nuclear Chemistry, and (3) Spectroscopy. Microwave absorption studies of the high Tsub(c) oxide superconductor YBa 2 Cu 3 Osub(7-x) using electron paramagnetic resonance techniques are the new feature during the report year. Radioanalytical services and radiation sources in the form of electrodeposited sources or standard soluti ons were also given to the other Divisions, other units of the Department of Atomic Energy, and other organisations in the country. A list of papers by the members of the Division published in various journals and presented at various symposia, conferences etc. is given at the end of the report. (M.G.B.). refs., 51 tabs., 33 figs

  12. Investigation of divisibility in a spreadsheet environment

    Directory of Open Access Journals (Sweden)

    Stanislav Lukáč

    2016-07-01

    Full Text Available This classroom note is focused on the application of inquiry approaches to teaching divisibility in the set of whole numbers. The main attention is devoted to the composition of a sequence of questions implemented within the spreadsheet environment, the solution of which should encourage students to actively learn and discover the divisibility rule for number eleven. This is an extra-curricular topic in Slovakia aimed to be taught in extended Mathematics classes as many of their students encounter it in competitions. An important part of the development of the questions on workbook sheets is the implementation of feedback which provides evaluation of students' solutions and auxiliary instructions for the guidance of learning.

  13. Chemical Technology Division. Annual technical report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Laidler, J.J.; Myles, K.M.; Green, D.W.; McPheeters, C.C.

    1996-06-01

    Highlights of the Chemical Technology (CMT) Division`s activities during 1995 are presented. In this period, CMT conducted research and development in the following areas: (1) electrochemical technology, including advanced batteries and fuel cells; (2) methods for treatment of hazardous waste and mixed hazardous/radioactive waste; (3) the reaction of nuclear waste glass and spent fuel under conditions expected for an unsaturated repository; (4) processes for separating and recovering selected elements from waste streams, concentrating low-level radioactive waste streams with advanced evaporator technology, and producing {sup 99}Mo from low-enriched uranium; (5) electrometallurgical treatment of different types of spent nuclear fuel in storage at Department of Energy sites; and (6) physical chemistry of selected materials in environments simulating those of fission and fusion energy systems.

  14. The Division of Labor, Investment, and Capital

    OpenAIRE

    Xiaokai Yang

    1999-01-01

    This paper uses a dynamic general equilibrium model based on corner solutions to formalize the classical theory of investment and capital which considers investment to be a vehicle for developing a high level of division of labor in roundabout productive activities. If it takes time for a specialist producer of tractors to learn the right method in producing commercially viable tractors, specialization in producing tractors is infeasible in the absence of investment in terms of consumption go...

  15. Energy and Environment Division annual report, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Camp, J.A. (ed.)

    1978-01-01

    Research activities of this Division are reported under nine separate programs, namely: Energy Analysis; Solar Energy; Energy-Efficient Buildings; Chemical Process Research and Development; Environmental Research; Atmospheric Aerosol Research; Oil Shale Research; Instrumentation Development; and Combustion Research. A separate abstract was prepared for each of the nine programs, each of which contained several individual research summaries, with responsible researchers listed. All of the abstracts will appear in Energy Research Abstracts (ERA), and five will appear in Energy Abstracts for Policy Analysis (EAPA).

  16. Division algebras, extended supersymmetries and applications

    Energy Technology Data Exchange (ETDEWEB)

    Toppan, F

    2001-09-01

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N = 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N = 8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given.

  17. Division algebras, extended supersymmetries and applications

    Science.gov (United States)

    Toppan, F.

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N = 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N = 8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given.

  18. Earth Sciences Division annual report 1980

    Energy Technology Data Exchange (ETDEWEB)

    1981-07-01

    Summaries of the highlights of programs in the Earth Sciences Division are presented under four headings; Geosciences, Geothermal Energy Development, Nuclear Waste Isolation, and Marine Sciences. Utilizing both basic and applied research in a wide spectrum of topics, these programs are providing results that will be of value in helping to secure the nation's energy future. Separate abstracts have been prepared for each project for inclusion in the Energy Data Base. (DMC)

  19. Division algebras, extended supersymmetries and applications

    International Nuclear Information System (INIS)

    Toppan, F.

    2001-01-01

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N = 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N = 8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given

  20. Division algebras, extended supersymmetries and applications

    International Nuclear Information System (INIS)

    Toppan, F.

    2001-03-01

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N= 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N=8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given. (author)