WorldWideScience

Sample records for tracer synthesis resources

  1. Synthesis of tracers using automated radiochemistry and robotics

    International Nuclear Information System (INIS)

    Dannals, R.F.

    1992-07-01

    Synthesis of high specific activity radiotracers labeled with short-lived positron-emitting radionuclides for positron emission tomography (PET) often requires handling large initial quantities of radioactivity. High specific activities are required when preparing tracers for use in PET studies of neuroreceptors. A fully automated approach for tracer synthesis is highly desirable. This proposal involves the development of a system for the Synthesis of Tracers using Automated Radiochemistry and Robotics (STARR) for this purpose. While the long range objective of the proposed research is the development of a totally automated radiochemistry system for the production of major high specific activity 11 C-radiotracers for use in PET, the specific short range objectives are the automation of 11 C-methyl iodide ( 11 CH 3 I) production via an integrated approach using both radiochemistry modular labstations and robotics, and the extension of this automated capability to the production of several radiotracers for PET (initially, 11 C-methionine, 3-N-[ 11 C-methyl]spiperone, and [ 11 C]-carfentanil)

  2. Optimization of Iron Oxide Tracer Synthesis for Magnetic Particle Imaging

    Directory of Open Access Journals (Sweden)

    Sabina Ziemian

    2018-03-01

    Full Text Available The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs. We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol gallic acid polymer and phase transferred to water (SC-SPIONs. Our aim was to obtain long-term stable particles in aqueous media with high MPI performance. We found that the amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS at 10 mT is 2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealing excellent MPI potential as compared to other reported MPI tracer particle preparations. We show that the reconstructed MPI images of phantoms using optimized multicore and specifically single-core particles are superior to that of commercially available Resovist, which we utilize as a reference standard, as predicted by MPS.

  3. Influence of nutrition on protein synthesis and 15N tracer data in man

    International Nuclear Information System (INIS)

    Faust, H.

    1984-01-01

    Quantitative studies and measurements of parameters of the protein metabolism in vivo require the isotope methodology. Different 15 N tracer methods with special modifications are available which can be used depending on clinical problems. The oral single pulse application of [ 15 N]glycine is equal to other isotope tracer techniques provided that the basic assumptions of the application are fullfilled. The protein metabolism is clearly influenced by the nutritional status whereby the protein synthesis is more sensitive than the breakdown to altered dietary intakes of protein and energy. The importance of standardized experimental conditions is emphasized for studies with 15 N and the interpretation of tracer data. (author)

  4. Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications

    Energy Technology Data Exchange (ETDEWEB)

    Visser, Anniek K.D.; Waarde, Aren van; Willemsen, Antoon T.M. [University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); Bosker, Fokko J. [University of Groningen, University Medical Center Groningen, University Center of Psychiatry, Groningen (Netherlands); Luiten, Paul G.M. [University of Groningen, Center for Behavior and Neurosciences, Department of Molecular Neurobiology, Haren (Netherlands); Boer, Johan A. den [University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University of Groningen, University Medical Center Groningen, University Center of Psychiatry, Groningen (Netherlands); Kema, Ido P. [University of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, Groningen (Netherlands); Dierckx, Rudi A.J.O. [University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen (Netherlands); University Hospital Ghent, Department of Nuclear Medicine, Ghent (Belgium)

    2011-03-15

    The serotonergic system of the brain is complex, with an extensive innervation pattern covering all brain regions and endowed with at least 15 different receptors (each with their particular distribution patterns), specific reuptake mechanisms and synthetic processes. Many aspects of the functioning of the serotonergic system are still unclear, partially because of the difficulty of measuring physiological processes in the living brain. In this review we give an overview of the conventional methods of measuring serotonin synthesis and methods using positron emission tomography (PET) tracers, more specifically with respect to serotonergic function in affective disorders. Conventional methods are invasive and do not directly measure synthesis rates. Although they may give insight into turnover rates, a more direct measurement may be preferred. PET is a noninvasive technique which can trace metabolic processes, like serotonin synthesis. Tracers developed for this purpose are {alpha}-[{sup 11}C]methyltryptophan ([{sup 11}C]AMT) and 5-hydroxy-L-[{beta}-{sup 11}C]tryptophan ([{sup 11}C]5-HTP). Both tracers have advantages and disadvantages. [{sup 11}C]AMT can enter the kynurenine pathway under inflammatory conditions (and thus provide a false signal), but this tracer has been used in many studies leading to novel insights regarding antidepressant action. [{sup 11}C]5-HTP is difficult to produce, but trapping of this compound may better represent serotonin synthesis. AMT and 5-HTP kinetics are differently affected by tryptophan depletion and changes of mood. This may indicate that both tracers are associated with different enzymatic processes. In conclusion, PET with radiolabelled substrates for the serotonergic pathway is the only direct way to detect changes of serotonin synthesis in the living brain. (orig.)

  5. Imaging of Enzymes in the Steroid Biosynthetic Pathway: Synthesis of 18F-Labelled Tracers

    International Nuclear Information System (INIS)

    Erlandsson, Maria

    2009-01-01

    This thesis deals with the synthesis and development of 18 F-labelled alkyl etomidate and vorozole analogues, and their use as positron emission tomography (PET) tracers for the imaging of the steroid enzymes 11β-hydroxylase and aromatase. Two synthetic 18 F-labelling approaches to the etomidate and vorozole analogues were developed, and the analogues were evaluated in some biological assays. The two-step labelling method was used to synthesise many compounds for biological evaluation. In the first step, a 18 F-labelled intermediate based on a ditosylate or a halogenated diethyl ether was synthesised and used directly in the next alkylation step. The decay-corrected (d.c.) radiochemical yield was higher compared to other known two-step labelling methods. Once an appropriate candidate has been chosen for clinical evaluation, a one-step labelling method will be more suitable. We therefore developed a method based on precursors that had leaving groups at the end of their alkyl chains, and used these directly in the 18 F-labelling synthesis. The one-step 18 F-labelling synthesis required less reaction time and produced higher specific radioactivity and d.c. radiochemical yield than our two-step synthesis. With microwave heating, the reaction time was reduced to seconds and the d.c. radiochemical yield was better than that obtained with conventional heating. The one-step synthesis simplified the technical handling by allowing the tracer syntheses to be automated on the TRACERLab FX FN

  6. Sustainable processes synthesis for renewable resources

    International Nuclear Information System (INIS)

    Halasz, L.; Povoden, G.; Narodoslawsky, M.

    2005-01-01

    Renewable resources pose special challenges to process synthesis. Due to decentral raw material generation, usually low transport densities and the perishable character of most renewable raw materials in combination with their time dependent availability, logistical questions as well as adaptation to regional agricultural structures are necessary. This calls for synthesis of structures not only of single processes but of the whole value chain attached to the utilisation of a certain resource. As most of the innovative technologies proposed to build on a renewable raw material base face stiff economic competition from fossil based processes, economic optimality of the value chain is crucial to their implementation. On top of this widening of the process definition for synthesis, many processes on the base of renewable resources apply technologies (like membrane separations, chromatographic purification steps, etc.) for which the heuristic knowledge is still slim. This reduces the choice of methods for process synthesis, mainly to methods based on combinatorial principles. The paper investigates applicability as well as impact on technology development of process synthesis for renewable raw material utilisation. It takes logistic considerations into account and applies process synthesis to the case study of the green biorefinery concept. The results show the great potential of process synthesis for technology development of renewable resource utilisation. Applied early in the development phase, it can point towards the most promising utilisation pathways, thus guiding the engineering work. On top of that, and even more important, it can help avoid costly development flops as it also clearly indicates 'blind alleys' that have to be avoided

  7. Contribution of isotopic and geochemical tracers to the administration of water resources: the strontium case

    International Nuclear Information System (INIS)

    Verdoux, P.; Lancelot, J.; Faillat, J.P.

    1995-01-01

    A better understanding of groundwater origin(s) and a quantitative and qualitative evaluation of exploited resources is a preliminary condition for rational administration and preventive actions. The determination of Sr contents and isotopic compositions associated or not to other elements is a new method applied in underground domains which has proven to be effective for example in Languedoc-Rousillon, particularly in areas where classical natural and even artificial tracers are unreliable. The use of 87 Sr/ 86 Sr tracer is based on the condition that each analysed rock-system is defined by a typical isotopic composition. In the Cevennes and Lozere, sedimentary carbonate rocks display 87 Sr/ 86 Sr ratios ranging from 0.707 to 0.709, similar to those of seawater,while silicate rocks exhibit values from 0.710 to 0.750, depending on Rb/Sr ratios, ages and resistance of the different minerals to weathering processes. Sr data obtained in the Lozere suggest important binary mixing of water between an homogeneous end member representing the composition of water flowing on the crystalline basement and a second component corresponding to water from karstic springs and to captive waters of the lower aquifer reached at 200 m in depth by borehole. Calculated mixing curves between the basement and the karstic water end members would allow to define the nature and volumetric importance of storage and to evaluate pollution risks. (J.S.). 17 refs., 9 figs., 3 tabs

  8. Environmental Tracers

    Directory of Open Access Journals (Sweden)

    Trevor Elliot

    2014-10-01

    Full Text Available Environmental tracers continue to provide an important tool for understanding the source, flow and mixing dynamics of water resource systems through their imprint on the system or their sensitivity to alteration within it. However, 60 years or so after the first isotopic tracer studies were applied to hydrology, the use of isotopes and other environmental tracers are still not routinely necessarily applied in hydrogeological and water resources investigations where appropriate. There is therefore a continuing need to promote their use for developing sustainable management policies for the protection of water resources and the aquatic environment. This Special Issue focuses on the robustness or fitness-for-purpose of the application and use of environmental tracers in addressing problems and opportunities scientifically, to promote their wider use and to address substantive issues of vulnerability, sustainability, and uncertainty in (groundwater resources systems and their management.

  9. Semi-automatic synthesis and biological evaluation of 18F-FCH as an oncologic PET tracer

    International Nuclear Information System (INIS)

    Wu Zhanhong; Wang Shizhen; Zhou Qian; Fu Zhe; Qiu Feichan; Huo Li

    2005-01-01

    18 F-fluromethylcholine ( 18 F-FCH) as a PET tracer is synthesized. The semi-automatic synthesis assembly of 18 F-FCH is modified from CPCU(CTI). The radiochemical purity is measured by analytical HPLC. The radiochemical yield and the radiochemical purity of 18 F-FCH are 15% and >99%, respectively. The total radiosynthesis time is 55 min after EOB. The labeled product exhibited low toxicity. The biodistribution in normal mice and the toxicity are studied. PET imaging with 18 F-FCH is performed on tumor xenograft murine model. The semi-automatic synthesis assembly is promising to be used for routine clinic radiopharmaceutical preparation and preliminary study has shown the usefulness of 18 F-FCH as an oncologic PET tracer. (authors)

  10. Synthesis of 1-[11C]-D,L-homocysteine thiolactone: a potential tracer for myocardial ischemia using PET

    International Nuclear Information System (INIS)

    Hamacher, K.; Hanus, J.

    1989-01-01

    The synthesis of 1-[ 11 C]-D,L-homocysteine thiolactone, a potential tracer for PET imaging of ischemic heart regions, is described. The labelling is achieved by reaction of [ 11 C]carbon dioxide with α-lithiated S-(tetrahydro-pyran-2-yl)3-thiopropylisonitrile. Deprotection of the mercapto group and lactonisation of the resulting thioamino acid is accomplished in an acid catalysed reaction. The radiochemical yield obtained is 10 to 15% and the synthesis time, including the HPLC purification is about 45 min. (author)

  11. Constraining Glacial Runoff Contributions to Water Resources in the Cordillera Real, Bolivia using Environmental Tracers

    Science.gov (United States)

    Guido, Z.; McIntosh, J. C.; Papuga, S. A.

    2013-12-01

    Warming temperatures in recent decades have contributed to substantial reductions in glaciers in many mountain regions around the globe, including the South American Andes. Melting of these glaciers taps water resources accumulated in past climates, and the diminishing ice marks a decrease in a nonrenewable water source that begs the question: how will future water supplies be impacted by climate change. Water resource management and climate adaptation efforts can be informed by knowledge of the extent to which glaciers contribute to seasonal streamflows, but remote locations and scant monitoring often limit this quantification. In Bolivia, more than two million people draw water from watersheds fed, in part, by glaciers. The amount to which these glaciers contribute to the water supply, however, is not well constrained. We apply elemental and isotopic tracers in an end-member mixing model to quantify glacial runoff contributions to local water supplies. We present oxygen and deuterium isotopes and major anion concentrations (sulfate and chloride) of shallow groundwater, streams, reservoirs, small arroyos, and glacial runoff. Isotopic and anion mixing models suggest between 45-67% of the water measured in high altitude streams originated from within the glacial footprint during the 2011 wet season, while glacial runoff contributed about 42-53% of the water in reservoirs in the 2012 dry season. Data also show that shallow groundwater is connected to glacial-fed streams. Any future decrease in glacial runoff may contribute to a reduction in surface water supplies and lower groundwater levels downstream, perhaps below the depth of hand-dug wells common in rural communities.

  12. Fully automated synthesis of 11C-acetate as tumor PET tracer by simple modified solid-phase extraction purification

    International Nuclear Information System (INIS)

    Tang, Xiaolan; Tang, Ganghua; Nie, Dahong

    2013-01-01

    Introduction: Automated synthesis of 11 C-acetate ( 11 C-AC) as the most commonly used radioactive fatty acid tracer is performed by a simple, rapid, and modified solid-phase extraction (SPE) purification. Methods: Automated synthesis of 11 C-AC was implemented by carboxylation reaction of MeMgBr on a polyethylene Teflon loop ring with 11 C-CO 2 , followed by acidic hydrolysis with acid and SCX cartridge, and purification on SCX, AG11A8 and C18 SPE cartridges using a commercially available 11 C-tracer synthesizer. Quality control test and animals positron emission tomography (PET) imaging were also carried out. Results: A high and reproducible decay-uncorrected radiochemical yield of (41.0±4.6)% (n=10) was obtained from 11 C-CO 2 within the whole synthesis time about 8 min. The radiochemical purity of 11 C-AC was over 95% by high-performance liquid chromatography (HPLC) analysis. Quality control test and PET imaging showed that 11 C-AC injection produced by the simple SPE procedure was safe and efficient, and was in agreement with the current Chinese radiopharmaceutical quality control guidelines. Conclusion: The novel, simple, and rapid method is readily adapted to the fully automated synthesis of 11 C-AC on several existing commercial synthesis module. The method can be used routinely to produce 11 C-AC for preclinical and clinical studies with PET imaging. - Highlights: • A fully automated synthesis of 11 C-acetate by simple modified solid-phase extraction purification has been developed. • Typical non-decay-corrected yields were (41.0±4.6)% (n=10) • Radiochemical purity was determined by radio-HPLC analysis on a C18 column using the gradient program, instead of expensive organic acid column or anion column. • QC testing (RCP>99%)

  13. Synthesis of radiolabelled organic compounds for use as water tracers in oil reservoirs

    International Nuclear Information System (INIS)

    Eriksen, D.Oe.; Bjoernstad, V.

    1999-01-01

    Injection of water into oil containing strata to maintain field pressure and to replace oil is usually the primary choice to enhance oil-recovery. Use of tracer methods is becoming an important part of the oil companies' basis for making economical decisions. Such water tracing requires passive tracers, i.e. compounds that behave exactly like the substance studied under the conditions of interest. This implies that a water-tracer in a water-flooded oil-field must fulfil requirements like no absorption to reservoir rock, no partitioning (or distribution) with respect to the other fluids present, long time thermal stability, microbial resistance and high detectability. In addition, the tracer compound has to be environmentally acceptable and available at a reasonable cost. Among the extensive number of compounds tested according to these criteria in the laboratory we have qualified four compounds as tracers for water in oil reservoirs. For three of them we propose radiolabelling syntheses with 14 C as radioactive label to lower detection limits. The compounds are benzene 1,2- and 1,3-dicarboxylic acids and benzene 1,3,5-tricarboxylic acid. (author)

  14. The single-biopsy approach in determining protein synthesis in human slow-turning-over tissue: use of flood-primed, continuous infusion of amino acid tracer

    DEFF Research Database (Denmark)

    Holm, Lars; Reitelseder, Søren; Dideriksen, Kasper

    2014-01-01

    Muscle protein synthesis (MPS) rate is determined conventionally by obtaining two or more tissue biopsies during a primed, continuous infusion of a stable isotopically labeled amino acid. The purpose of the present study was to test whether tracer priming given as a flooding dose, thereby securing....... In conclusion, the flood-primed, continuous infusion protocol using phenylalanine as tracer can validly be used to measure the protein synthesis rate in human in vivo experiments by obtaining only a single tissue biopsy after a prolonged infusion period....

  15. Multi-contrast attenuation map synthesis for PET/MR scanners: assessment on FDG and Florbetapir PET tracers

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, Ninon [University College London, Translational Imaging Group, Centre for Medical Image Computing, London (United Kingdom); Cardoso, M.J.; Modat, Marc; Ourselin, Sebastien [University College London, Translational Imaging Group, Centre for Medical Image Computing, London (United Kingdom); University College London, Dementia Research Centre, Institute of Neurology, London (United Kingdom); Thielemans, Kris; Dickson, John [University College London, Institute of Nuclear Medicine, London (United Kingdom); Schott, Jonathan M. [University College London, Dementia Research Centre, Institute of Neurology, London (United Kingdom); Atkinson, David [University College London, Centre for Medical Imaging, London (United Kingdom); Arridge, Simon R. [University College London, Centre for Medical Image Computing, London (United Kingdom); Hutton, Brian F. [University College London, Institute of Nuclear Medicine, London (United Kingdom); University of Wollongong, Centre for Medical Radiation Physics, Wollongong, NSW (Australia)

    2015-08-15

    Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) scanners are expected to offer a new range of clinical applications. Attenuation correction is an essential requirement for quantification of PET data but MRI images do not directly provide a patient-specific attenuation map. Methods We further validate and extend a Computed Tomography (CT) and attenuation map (μ-map) synthesis method based on pre-acquired MRI-CT image pairs. The validation consists of comparing the CT images synthesised with the proposed method to the original CT images. PET images were acquired using two different tracers ({sup 18}F-FDG and {sup 18}F-florbetapir). They were then reconstructed and corrected for attenuation using the synthetic μ-maps and compared to the reference PET images corrected with the CT-based μ-maps. During the validation, we observed that the CT synthesis was inaccurate in areas such as the neck and the cerebellum, and propose a refinement to mitigate these problems, as well as an extension of the method to multi-contrast MRI data. Results With the improvements proposed, a significant enhancement in CT synthesis, which results in a reduced absolute error and a decrease in the bias when reconstructing PET images, was observed. For both tracers, on average, the absolute difference between the reference PET images and the PET images corrected with the proposed method was less than 2%, with a bias inferior to 1%. Conclusion With the proposed method, attenuation information can be accurately derived from MRI images by synthesising CT using routine anatomical sequences. MRI sequences, or combination of sequences, can be used to synthesise CT images, as long as they provide sufficient anatomical information. (orig.)

  16. Synthesis of isotopically modified ZnO nanoparticles and their potential as nanotoxicity tracers

    Energy Technology Data Exchange (ETDEWEB)

    Dybowska, Agnieszka D., E-mail: a.dybowska@nhm.ac.u [Department of Mineralogy, Natural History Museum London, Cromwell Road, London, SW7 5BD (United Kingdom); Croteau, Marie-Noele [U.S. Geological Survey, 345 Middlefield Road, MS 496, Menlo Park, CA 94025 (United States); Misra, Superb K.; Berhanu, Deborah [Department of Mineralogy, Natural History Museum London, Cromwell Road, London, SW7 5BD (United Kingdom); Luoma, Samuel N. [Department of Mineralogy, Natural History Museum London, Cromwell Road, London, SW7 5BD (United Kingdom); U.S. Geological Survey, 345 Middlefield Road, MS 496, Menlo Park, CA 94025 (United States); Christian, Paul; O' Brien, Paul [School of Chemistry, University of Manchester, M13 9PL, Manchester (United Kingdom); Valsami-Jones, Eugenia [Department of Mineralogy, Natural History Museum London, Cromwell Road, London, SW7 5BD (United Kingdom)

    2011-01-15

    Understanding the behavior of engineered nanoparticles in the environment and within organisms is perhaps the biggest obstacle to the safe development of nanotechnologies. Reliable tracing is a particular issue for nanoparticles such as ZnO, because Zn is an essential element and a common pollutant thus present at elevated background concentrations. We synthesized isotopically enriched (89.6%) with a rare isotope of Zn ({sup 67}Zn) ZnO nanoparticles and measured the uptake of {sup 67}Zn by L. stagnalis exposed to diatoms amended with the particles. Stable isotope technique is sufficiently sensitive to determine the uptake of Zn at an exposure equivalent to lower concentration range (<15 {mu}g g{sup -1}). Without a tracer, detection of newly accumulated Zn is significant at Zn exposure concentration only above 5000 {mu}g g{sup -1} which represents some of the most contaminated Zn conditions. Only by using a tracer we can study Zn uptake at a range of environmentally realistic exposure conditions. - ZnO nanoparticles with distinct isotopic composition can be tailor synthesized to be used as tracers of environmental fate and uptake by organisms.

  17. Synthesis of isotopically modified ZnO nanoparticles and their potential as nanotoxicity tracers

    International Nuclear Information System (INIS)

    Dybowska, Agnieszka D.; Croteau, Marie-Noele; Misra, Superb K.; Berhanu, Deborah; Luoma, Samuel N.; Christian, Paul; O'Brien, Paul; Valsami-Jones, Eugenia

    2011-01-01

    Understanding the behavior of engineered nanoparticles in the environment and within organisms is perhaps the biggest obstacle to the safe development of nanotechnologies. Reliable tracing is a particular issue for nanoparticles such as ZnO, because Zn is an essential element and a common pollutant thus present at elevated background concentrations. We synthesized isotopically enriched (89.6%) with a rare isotope of Zn ( 67 Zn) ZnO nanoparticles and measured the uptake of 67 Zn by L. stagnalis exposed to diatoms amended with the particles. Stable isotope technique is sufficiently sensitive to determine the uptake of Zn at an exposure equivalent to lower concentration range ( -1 ). Without a tracer, detection of newly accumulated Zn is significant at Zn exposure concentration only above 5000 μg g -1 which represents some of the most contaminated Zn conditions. Only by using a tracer we can study Zn uptake at a range of environmentally realistic exposure conditions. - ZnO nanoparticles with distinct isotopic composition can be tailor synthesized to be used as tracers of environmental fate and uptake by organisms.

  18. Total synthesis of [2-11C]thymidine from [11C]urea: A tracer of choice for measurement of cellular proliferation using PET

    International Nuclear Information System (INIS)

    Labar, D.; Vander Borght, T.

    1990-01-01

    In preliminary studies of cellular proliferation with [methyl- 11 C]thymidine, the labelled degradative products mask the progressive incorporation of the tracer into DNA. The authors have developed a procedure for the synthesis of [2- 11 C]thymidine to circumvent this difficulty, using a [ 11 C]urea precursor

  19. Double-tracer autoradiographic study of protein synthesis and glucose consumption in rats with focal cerebral ischemia

    DEFF Research Database (Denmark)

    Christensen, Thomas; Balchen, T; Bruhn, T

    1999-01-01

    A double-tracer autoradiographic method for simultaneous measurement of regional glucose utilization (rCMRglc) and regional protein synthesis (PS) in consecutive brain sections is described and applied to study the metabolism of the ischemic penumbra 2 h after occlusion of the middle cerebral...... artery (MCAO) in rats. In halothane anesthesia, the left middle cerebral artery was permanently occluded. Two hours after MCAO an i.v. bolus injection of 14C-deoxyglucose and 3H-leucine was given and circulated for 45 min. Two sets of brain sections were processed for quantitative autoradiography....... Neighboring brain sections exposed an X-ray film (3H-insensitive), and a 3H-sensitive for determination of rCMRglc and PS, respectively. Sections for PS determination were washed in trichloroacetic acid (TCA) prior to film exposure in order to remove 14C-deoxyglucose and unincorporated 3H-leucine. Regional...

  20. Synthesis of isotopically modified ZnO nanoparticles and their potential as nanotoxicity tracers.

    Science.gov (United States)

    Dybowska, Agnieszka D; Croteau, Marie-Noele; Misra, Superb K; Berhanu, Deborah; Luoma, Samuel N; Christian, Paul; O'Brien, Paul; Valsami-Jones, Eugenia

    2011-01-01

    Understanding the behavior of engineered nanoparticles in the environment and within organisms is perhaps the biggest obstacle to the safe development of nanotechnologies. Reliable tracing is a particular issue for nanoparticles such as ZnO, because Zn is an essential element and a common pollutant thus present at elevated background concentrations. We synthesized isotopically enriched (89.6%) with a rare isotope of Zn (67Zn) ZnO nanoparticles and measured the uptake of 67Zn by L. stagnalis exposed to diatoms amended with the particles. Stable isotope technique is sufficiently sensitive to determine the uptake of Zn at an exposure equivalent to lower concentration range (<15 μg g(-1)). Without a tracer, detection of newly accumulated Zn is significant at Zn exposure concentration only above 5000 μg g(-1) which represents some of the most contaminated Zn conditions. Only by using a tracer we can study Zn uptake at a range of environmentally realistic exposure conditions. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. Synthesis of isotopically modified ZnO nanoparticles and their potential as nanotoxicity tracers

    Science.gov (United States)

    Dybowska, A.D.; Croteau, M.-N.; Misra, S.K.; Berhanu, D.; Luoma, S.N.; Christian, P.; O'Brien, P.; Valsami-Jones, E.

    2011-01-01

    Understanding the behavior of engineered nanoparticles in the environment and within organisms is perhaps the biggest obstacle to the safe development of nanotechnologies. Reliable tracing is a particular issue for nanoparticles such as ZnO, because Zn is an essential element and a common pollutant thus present at elevated background concentrations. We synthesized isotopically enriched (89.6%) with a rare isotope of Zn (67Zn) ZnO nanoparticles and measured the uptake of 67Zn by L. stagnalis exposed to diatoms amended with the particles. Stable isotope technique is sufficiently sensitive to determine the uptake of Zn at an exposure equivalent to lower concentration range (<15 ??g g-1). Without a tracer, detection of newly accumulated Zn is significant at Zn exposure concentration only above 5000 ??g g-1 which represents some of the most contaminated Zn conditions. Only by using a tracer we can study Zn uptake at a range of environmentally realistic exposure conditions. ?? 2010 Elsevier Ltd. All rights reserved.

  2. In vitro estimation of rumen microbial protein synthesis of water buffaloes using 30S as tracer

    International Nuclear Information System (INIS)

    Hendratno, C.; Abidin, Z.; Bahaudin, R.; Sastrapradja, D.

    1977-01-01

    An experiment to study the effect of diet and individual differences of animals on the in vitro estimation of rumen microbial protein synthesis in young female water buffaloes using the technique of inorganic 35 S incorporation, is described. The dietary treatments were four combinations of roughage supplemented with cassava meal. From the value of rate constant for dilution of radioactivity in the sulphide pool and percentage of inorganic 35 S incorporated into microbial protein, it can be concluded that individual differences of animals have no influence on the efficiency of microbial protein synthesis. Feed composition, on the other hand, tends to have some influence on the efficiency of protein synthesis(P3O.15). (author)

  3. Radionuclides as tracers of coastal processes in Brazil: review, synthesis, and perspectives

    International Nuclear Information System (INIS)

    Santos, Isaac R.; Burnett, William C.

    2008-01-01

    We review the usefulness, limitations, significance, and coastal management implications of radionuclide measurements in Brazilian coastal environments. We focus on the use of radionuclides as tracers of sedimentary processes and submarine groundwater discharge (SGD). We also discuss artificial radionuclide contamination and high natural radioactivity areas. The interpretation of 14 C-, 137 Cs-, and 210 Pb-derived sedimentation rates has provided evidence that inappropriate soil use by urban and agricultural activities has intensified erosion processes on land, which is reflected in depositional environments, such as coastal lagoons, estuaries and mangroves. Of the processes discussed in this paper, SGD is the one that requires the most scientific effort in the short-term. There have been only two case studies using 222 Rn and radium isotopes as groundwater tracers in Brazil. These investigations showed that SGD can be a major source of nutrients and other dissolved species to the coastal ocean. Baseline 137 Cs, 90 Sr, 239+240 Pu, and 238 Pu concentrations in seawater from the whole Brazilian coastal zone are very low. Therefore, in spite of contamination problems in many ecosystems in the northern hemisphere, artificial radionuclide pollution appears to be negligible along the Brazilian coast. Phosphate fertilizer industries and petroleum processing facilities are the main economic activities producing Technologically Enhanced Naturally Occurring Radioactive Materials (TENORM). Even though a few attempts have been made to assess the radiological effects of these activities, their potential threats indicate a need for the radiological control of their wastes. This review showed that the number of studies within the field of environmental radioactivity is still small in Brazil and much more research is needed to understand processes of high interest for environmental managers. In the near future, it is likely that such studies in Brazil will move from descriptive

  4. Radionuclides as tracers of coastal processes in Brazil: review, synthesis, and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Isaac R.; Burnett, William C., E-mail: santos@ocean.fsu.edu [Florida State University, Tallahassee, FL (United States). Dept. of Oceanography. Environmental Radioactivity Measurement Facility; Godoy, Jose M. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2008-04-15

    We review the usefulness, limitations, significance, and coastal management implications of radionuclide measurements in Brazilian coastal environments. We focus on the use of radionuclides as tracers of sedimentary processes and submarine groundwater discharge (SGD). We also discuss artificial radionuclide contamination and high natural radioactivity areas. The interpretation of {sup 14}C-, {sup 137}Cs-, and {sup 210}Pb-derived sedimentation rates has provided evidence that inappropriate soil use by urban and agricultural activities has intensified erosion processes on land, which is reflected in depositional environments, such as coastal lagoons, estuaries and mangroves. Of the processes discussed in this paper, SGD is the one that requires the most scientific effort in the short-term. There have been only two case studies using {sup 222}Rn and radium isotopes as groundwater tracers in Brazil. These investigations showed that SGD can be a major source of nutrients and other dissolved species to the coastal ocean. Baseline {sup 137}Cs, {sup 90}Sr, {sup 239+240}Pu, and {sup 238}Pu concentrations in seawater from the whole Brazilian coastal zone are very low. Therefore, in spite of contamination problems in many ecosystems in the northern hemisphere, artificial radionuclide pollution appears to be negligible along the Brazilian coast. Phosphate fertilizer industries and petroleum processing facilities are the main economic activities producing Technologically Enhanced Naturally Occurring Radioactive Materials (TENORM). Even though a few attempts have been made to assess the radiological effects of these activities, their potential threats indicate a need for the radiological control of their wastes. This review showed that the number of studies within the field of environmental radioactivity is still small in Brazil and much more research is needed to understand processes of high interest for environmental managers. In the near future, it is likely that such studies

  5. Guiding principles for estimation of whole-body synthesis rates by tracer experiments

    International Nuclear Information System (INIS)

    Krawielitzki, K.; Schadereit, R.; Wuensche, J.

    1989-01-01

    Methodical recommendations are suggested-predominantly for laboratory and small animals (rats and young chickens)-for the determination of parameters of the protein metabolism of the whole body after single dosis of a mixture of 15 N-labelled amino acids by means of the determination of the temporal course of cumulative 15 N excretion in urine and the assessment of the tracer kinetic data in a compartment model. These recommendations are to make it possible to carry out purposefully such experiments under comparable conditions. The advantages of this method are: (1) the non-invasive character of the method; (2) the possibility of repeating the experiment with the same animal; (3) the adaptability to other methods of investigation (e.g. measuring energy metabolism); (4) the relatively low expenditure of labour and requirement of test animals; (5) the relatively good reproducibility of the method. Thus this method is a good supplement to the flooding and permanent infusion methods and should be used wherever the determination of parameters of the protein metabolism of the total body is sufficient. (author)

  6. Synthesis of high specific activity carbon-11 labeled tracers for neuroreceptor studies

    International Nuclear Information System (INIS)

    Dannals, R.F.; Ravert, H.T.; Wilson, A.A.; Wagner, H.N. Jr; Johns Hopkins Medical Institutions, Baltimore, MD

    1989-01-01

    The use of short-lived positron-emitting radiotracers together with positron emission tomography (PET) has allowed scientists to acquire previously inaccessible information regarding problems in physiology, biochemistry, and pharmacology in the living human body. In the past five years, successes in the application of PET to the non-invasive determination of the spatial distribution and regional concentration of a variety of neurotransmitter binding sites within the living brain often followed the successful selections and syntheses of appropriately radiolabeled ligands. This presentation concentrates on the synthesis of these high specific activity radiotracers for neuroreceptor PET studies labeled specifically with carbon-11. (author). 15 refs.; 1 fig

  7. Fully automated synthesis of ¹¹C-acetate as tumor PET tracer by simple modified solid-phase extraction purification.

    Science.gov (United States)

    Tang, Xiaolan; Tang, Ganghua; Nie, Dahong

    2013-12-01

    Automated synthesis of (11)C-acetate ((11)C-AC) as the most commonly used radioactive fatty acid tracer is performed by a simple, rapid, and modified solid-phase extraction (SPE) purification. Automated synthesis of (11)C-AC was implemented by carboxylation reaction of MeMgBr on a polyethylene Teflon loop ring with (11)C-CO2, followed by acidic hydrolysis with acid and SCX cartridge, and purification on SCX, AG11A8 and C18 SPE cartridges using a commercially available (11)C-tracer synthesizer. Quality control test and animals positron emission tomography (PET) imaging were also carried out. A high and reproducible decay-uncorrected radiochemical yield of (41.0 ± 4.6)% (n=10) was obtained from (11)C-CO2 within the whole synthesis time about 8 min. The radiochemical purity of (11)C-AC was over 95% by high-performance liquid chromatography (HPLC) analysis. Quality control test and PET imaging showed that (11)C-AC injection produced by the simple SPE procedure was safe and efficient, and was in agreement with the current Chinese radiopharmaceutical quality control guidelines. The novel, simple, and rapid method is readily adapted to the fully automated synthesis of (11)C-AC on several existing commercial synthesis module. The method can be used routinely to produce (11)C-AC for preclinical and clinical studies with PET imaging. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Tumoral tracers

    International Nuclear Information System (INIS)

    Camargo, E.E.

    1979-01-01

    Direct tumor tracers are subdivided in the following categories:metabolite tracers, antitumoral tracers, radioactive proteins and cations. Use of 67 Ga-citrate as a clinically important tumoral tracer is emphasized and gallium-67 whole-body scintigraphy is discussed in detail. (M.A.) [pt

  9. Fully automated preparation of [11C]choline and [18F]fluoromethylcholine using TracerLab synthesis modules and facilitated quality control using analytical HPLC

    International Nuclear Information System (INIS)

    Shao Xia; Hockley, Brian G.; Hoareau, Raphael; Schnau, Paul L.; Scott, Peter J.H.

    2011-01-01

    Modifications of a GE TracerLab FX C-Pro , which can be implemented for solid-phase [ 11 C]methylation are described. The simplified procedure for synthesis of [ 11 C]choline uses a single Sep-Pak CM-Light cation-exchange cartridge for both solid-supported reaction and purification. Compared with the commonly used two Sep-Pak method, the low back-pressure of this Sep-Pak enables efficient and reliable production of [ 11 C]choline using a TracerLab FX C-Pro without requirement for any gas pressure adjustment. Typical radiochemical yields (RCY) are >60%, radiochemical purity (RCP) is 99.9% and levels of residual precursor in the final product, which may inhibit the uptake of [ 11 C]choline, are reduced to 1 μg/mL. Similarly, modification of a GE TracerLab FX FN is reported which enables gas-phase production of [ 18 F]fluoromethylcholine, suitable for pre-clinical use, (in 4-6% RCY and >99.7% RCP) using a related Sep-Pak method. These modifications can be utilized for solid-phase [ 11 C]methylation and [ 18 F]fluoromethylation of other radiotracers, and allow straightforward switching to other module configurations for solution-phase radiochemistry or loop chemistry. In addition, we report a convenient HPLC ion chromatography method, which can monitor residual precursor and the radiochemical purity of product at the same time, providing highly efficient quality control for routine clinical application. The reported HPLC method is appropriate for analysis of doses of both [ 11 C]choline and [ 18 F]fluoromethylcholine, and eliminates the need for a GC method to determine residual precursor levels. -- Graphical abstract: Simplified procedures for the automated synthesis of [ 11 C]choline and [ 18 F]fluoromethylcholine using TracerLab FX C-Pro and TracerLab FX FN synthesis modules are presented. In addition, we report a convenient HPLC ion chromatography method, which can monitor residual precursor and radiochemical purity of the product at the same time. Display Omitted

  10. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey

    International Nuclear Information System (INIS)

    Hostetler, Eric D.; Sanabria-Bohórquez, Sandra; Fan Hong; Zeng, Zhizhen; Gammage, Linda; Miller, Patricia; O'Malley, Stacey; Connolly, Brett; Mulhearn, James; Harrison, Scott T.; Wolkenberg, Scott E.; Barrow, James C.; Williams, David L.; Hargreaves, Richard J.; Sur, Cyrille; Cook, Jacquelynn J.

    2011-01-01

    Introduction: An 18 F-labeled positron emission tomography (PET) tracer for amyloid plaque is desirable for early diagnosis of Alzheimer's disease, particularly to enable preventative treatment once effective therapeutics are available. Similarly, such a tracer would be useful as a biomarker for enrollment of patients in clinical trials for evaluation of antiamyloid therapeutics. Furthermore, changes in the level of plaque burden as quantified by an amyloid plaque PET tracer may provide valuable insights into the effectiveness of amyloid-targeted therapeutics. This work describes our approach to evaluate and select a candidate PET tracer for in vivo quantification of human amyloid plaque. Methods: Ligands were evaluated for their in vitro binding to human amyloid plaques, lipophilicity and predicted blood–brain barrier permeability. Candidates with favorable in vitro properties were radiolabeled with 18 F and evaluated in vivo. Baseline PET scans in rhesus monkey were conducted to evaluate the regional distribution and kinetics of each tracer using tracer kinetic modeling methods. High binding potential in cerebral white matter and cortical grey matter was considered an unfavorable feature of the candidate tracers. Results: [ 18 F]MK-3328 showed the most favorable combination of low in vivo binding potential in white matter and cortical grey matter in rhesus monkeys, low lipophilicity (Log D=2.91) and high affinity for human amyloid plaques (IC 50 =10.5±1.3 nM). Conclusions: [ 18 F]MK-3328 was identified as a promising PET tracer for in vivo quantification of amyloid plaques, and further evaluation in humans is warranted.

  11. A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells

    International Nuclear Information System (INIS)

    Saeed, Muhammad; Tewson, Timothy J.; Erdahl, Colbin E.; Kohen, Amnon

    2012-01-01

    Introduction: Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11 CH 3 Ito[ 11 C]-formaldehyde ( 11 CH 2 O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a preferential uptake of [11- 14 C]-(R)-N 5 ,N 10 -methylene-5,6,7,8-tetrahydrofolate ( 14 CH 2 H 4 folate) by cancerous cell vs. normal cells from the same organ (Saeed M., Sheff D. and Kohen A. Novel positron emission tomography tracer distinguishes normal from cancerous cells. J Biol Chem 2011;286:33872–33878), pointing out 11 CH 2 H 4 folate as a positron emission tomography (PET) tracer for cancer imaging. Herein we report the synthesis of 11 CH 2 H 4 folate, which may serve as a potential PET tracer. Methods: In a remotely controlled module, methyl iodide ( 11 CH 3 I) was bubbled into a reaction vial containing trimethylamine N-oxide in N,N-Dimethylformamide (DMF) and heated to 70°C for 2 min. Formaldehyde ( 11 CH 2 O) formed after the completion of reaction was then mixed with a solution of freshly prepared tetrahydrofolate (H 4 folate) by using a fast chemoenzymatic approach to accomplish synthesis of 11 CH 2 H 4 folate. Purification of the product was carried out by loading the crude reaction mixture on a SAX cartridge, washing with water to remove unbound impurities and finally eluting with a saline solution. Results: The synthesis and purification of 11 CH 2 H 4 folate were completed within 5 min. High-performance liquid chromatography analysis of the product after SAX purification indicates that more than 90% of the radioactivity that was retained on the SAX cartridge was in 11 CH 2 H 4 folate, with minor ( 11 CH 2 O. Conclusion: We present a fast (∼5 min) synthesis and purification of 11 CH 2 H 4 folate as a potential PET tracer. The final product is received in physiologically compatible buffer (100 mM sodium phosphate, pH 7

  12. Synthesis and preclinical evaluation of [{sup 11}C]PAQ as a PET imaging tracer for VEGFR-2

    Energy Technology Data Exchange (ETDEWEB)

    Samen, Erik; Stone-Elander, Sharon [Karolinska University Hospital Solna, Karolinska Pharmacy, Stockholm (Sweden); Karolinska Institutet, Clinical Neurosciences, Stockholm (Sweden); Thorell, Jan-Olov [Karolinska University Hospital Solna, Karolinska Pharmacy, Stockholm (Sweden); Lu, Li [Karolinska Institutet, Clinical Neurosciences, Stockholm (Sweden); Tegnebratt, Tetyana; Holmgren, Lars [Karolinska Institutet, Cancer Center Karolinska, Oncology-Pathology, Stockholm (Sweden)

    2009-08-15

    (R,S)-N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methoxy)-4-quinazolinamine (PAQ) is a tyrosine kinase inhibitor with high affinity for the vascular endothelial growth factor receptor 2 (VEGFR-2), which plays an important role in tumour angiogenesis. The aim of this work was to develop and evaluate in mice the {sup 11}C-labelled analogue as an in vivo tracer for VEGFR-2 expression in solid tumours. [{sup 11}C]PAQ was synthesized by an N-methylation of desmethyl-PAQ using [{sup 11}C]methyl iodide. The tracer's pharmacokinetic properties and its distribution in both subcutaneous and intraperitoneal tumour models were evaluated with positron emission tomography (PET). [{sup 18}F]FDG was used as a reference tracer for tumour growth. PET results were corroborated by ex vivo and in vitro phosphor imaging and immunohistochemical analyses. In vitro assays and PET in healthy animals revealed low tracer metabolism, limited excretion over 60 min and a saturable and irreversible binding. Radiotracer uptake in subcutaneous tumour masses was low, while focal areas of high uptake (up to 8% ID/g) were observed in regions connecting the tumour to the host. Uptake was similarly high but more distributed in tumours growing within the peritoneum. The pattern of radiotracer uptake was generally different from that of the metabolic tracer [{sup 18}F]FDG and correlated well with variations in VEGFR-2 expression determined ex vivo by immunohistochemical analysis. These results suggest that [{sup 11}C]PAQ has potential as a noninvasive PET tracer for in vivo imaging of VEGFR-2 expression in angiogenic ''hot spots''. (orig.)

  13. Synthesis and preclinical evaluation of [11C]PAQ as a PET imaging tracer for VEGFR-2

    International Nuclear Information System (INIS)

    Samen, Erik; Stone-Elander, Sharon; Thorell, Jan-Olov; Lu, Li; Tegnebratt, Tetyana; Holmgren, Lars

    2009-01-01

    R,S-N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methox y)-4-quinazolinamine (PAQ) is a tyrosine kinase inhibitor with high affinity for the vascular endothelial growth factor receptor 2 (VEGFR-2), which plays an important role in tumour angiogenesis. The aim of this work was to develop and evaluate in mice the 11 C-labelled analogue as an in vivo tracer for VEGFR-2 expression in solid tumours. [ 11 C]PAQ was synthesized by an N-methylation of desmethyl-PAQ using [ 11 C]methyl iodide. The tracer's pharmacokinetic properties and its distribution in both subcutaneous and intraperitoneal tumour models were evaluated with positron emission tomography (PET). [ 18 F]FDG was used as a reference tracer for tumour growth. PET results were corroborated by ex vivo and in vitro phosphor imaging and immunohistochemical analyses. In vitro assays and PET in healthy animals revealed low tracer metabolism, limited excretion over 60 min and a saturable and irreversible binding. Radiotracer uptake in subcutaneous tumour masses was low, while focal areas of high uptake (up to 8% ID/g) were observed in regions connecting the tumour to the host. Uptake was similarly high but more distributed in tumours growing within the peritoneum. The pattern of radiotracer uptake was generally different from that of the metabolic tracer [ 18 F]FDG and correlated well with variations in VEGFR-2 expression determined ex vivo by immunohistochemical analysis. These results suggest that [ 11 C]PAQ has potential as a noninvasive PET tracer for in vivo imaging of VEGFR-2 expression in angiogenic ''hot spots''. (orig.)

  14. Synthesis and preclinical evaluation of [(11)C]PAQ as a PET imaging tracer for VEGFR-2.

    Science.gov (United States)

    Samén, Erik; Thorell, Jan-Olov; Lu, Li; Tegnebratt, Tetyana; Holmgren, Lars; Stone-Elander, Sharon

    2009-08-01

    (R,S)-N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)methoxy)-4-quinazolinamine (PAQ) is a tyrosine kinase inhibitor with high affinity for the vascular endothelial growth factor receptor 2 (VEGFR-2), which plays an important role in tumour angiogenesis. The aim of this work was to develop and evaluate in mice the (11)C-labelled analogue as an in vivo tracer for VEGFR-2 expression in solid tumours. [(11)C]PAQ was synthesized by an N-methylation of desmethyl-PAQ using [(11)C]methyl iodide. The tracer's pharmacokinetic properties and its distribution in both subcutaneous and intraperitoneal tumour models were evaluated with positron emission tomography (PET). [(18)F]FDG was used as a reference tracer for tumour growth. PET results were corroborated by ex vivo and in vitro phosphor imaging and immunohistochemical analyses. In vitro assays and PET in healthy animals revealed low tracer metabolism, limited excretion over 60 min and a saturable and irreversible binding. Radiotracer uptake in subcutaneous tumour masses was low, while focal areas of high uptake (up to 8% ID/g) were observed in regions connecting the tumour to the host. Uptake was similarly high but more distributed in tumours growing within the peritoneum. The pattern of radiotracer uptake was generally different from that of the metabolic tracer [(18)F]FDG and correlated well with variations in VEGFR-2 expression determined ex vivo by immunohistochemical analysis. These results suggest that [(11)C]PAQ has potential as a noninvasive PET tracer for in vivo imaging of VEGFR-2 expression in angiogenic "hot spots".

  15. Tracer theory

    International Nuclear Information System (INIS)

    Margrita, R.

    1988-09-01

    Tracers are used in many fields of science to investigate mass transfer. The scope of tracers applications in Service of Applications Radioisotopes (S.A.R.-France) is large and concerns natural and industrial systems such as Sciences of earth: hydrology - civil engineering - Sedimentology - environmental studies. Industrial field: chemical engineering - mechanical engineering. A general tracer methodology has been developed in our laboratories from these different applications fields and this paper shows these different points of view in using tracers; our wish is that the methods used in an experimental field can be employed in an another one

  16. Development of a New Positron Emission Tomography Tracer for Targeting Tumor Angiogenesis: Synthesis, Small Animal Imaging, and Radiation Dosimetry

    Directory of Open Access Journals (Sweden)

    David S. Lalush

    2013-05-01

    Full Text Available Angiogenesis plays a key role in cancer progression and correlates with disease aggressiveness and poor clinical outcomes. Affinity ligands discovered by screening phage display random peptide libraries can be engineered to molecularly target tumor blood vessels for noninvasive imaging and early detection of tumor aggressiveness. In this study, we tested the ability of a phage-display-selected peptide sequence recognizing specifically bone marrow- derived pro-angiogenic tumor-homing cells, the QFP-peptide, radiolabeled with 64Cu radioisotope to selectively image tumor vasculature in vivo by positron emission tomography (PET. To prepare the targeted PET tracer we modified QFP-phage with the DOTA chelator and radiolabeled the purified QFP-phage-DOTA intermediate with 64Cu to obtain QFP-targeted radioconjugate with high radiopharmaceutical yield and specific activity. We evaluated the new PET tracer in vivo in a subcutaneous (s.c. Lewis lung carcinoma (LLC mouse model and conducted tissue distribution, small animal PET/CT imaging study, autoradiography, histology, fluorescence imaging, and dosimetry assessments. The results from this study show that, in the context of the s.c. LLC immunocompetent mouse model, the QFP-tracer can target tumor blood vessels selectively. However, further optimization of the biodistribution and dosimetry profile of the tracer is necessary to ensure efficient radiopharmaceutical applications enabled by the biological specificity of the QFP-peptide.

  17. Development of a new structure for in vivo tracers synthesis: application to tumor neo-angiogenesis imaging

    International Nuclear Information System (INIS)

    Martinage, O.

    2012-01-01

    Molecular imaging is an essential non-invasive tool usable for diagnosis and characterisation of many diseases. Technetium-based tracers are the most popular ones due to availability, cost and radiochemical properties of 99m Tc. Nevertheless, effective tracers development requires a long, expensive, and mainly empirical optimisation process. This context prompted us to carry on the development of a new technetium structure which exhibits lots of potential functionalization spots compatible with a combinatorial approach. We synthesised 12 N 3 X (X = N, O, S) different ligands. Each of them includes a triazole moiety, (formed via a click-chemistry reaction), which is involved in the metal complexation that implies one of its nitrogen atoms. Then we evaluated their ability to readily form oxo-technetium complexes in conditions that are compatible with medical use in hospital. One complex was formed in quantitative yields and its stability in mice plasma was investigated. A complex called TriaS- 99m Tc, stable to more than 90% after 6 h incubation, was selected. In vivo study of TriaS- 99m Tc revealed an efficient blood clearance via the urinary excretion pathway with very low degradation. As an application, we used this structure for the development of tracers that target integrin α v β 3 , a known bio-marker of tumor neo-angiogenesis. First, we synthesised functionalized TriaS-based integrated complexes. Functional modification of TriaS by addition of side chains and substituents did not affect its ability to chelate oxo-technetium quantitatively. In addition, its stability in mice plasma was satisfactory. We also developed a bifunctional approach using c(RGDfK) peptide as the targeting biomolecule. In this way, a variable moiety (herein a PEG moiety) can be inserted in the structure through click-chemistry in order to modulate tracers solubility, biodistribution and excretion. (author) [fr

  18. Synthesis of carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives as new potential PET tracers for imaging of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

    Science.gov (United States)

    Gao, Mingzhang; Wang, Min; Zheng, Qi-Huang

    2016-03-01

    The target tracer carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives, N-(3-[(11)C]methoxy-4-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (3-[(11)C]4a) and N-(4-[(11)C]methoxy-3-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (4-[(11)C]4a); 2-((6-amino-9H-purin-8-yl)thio)-N-(3-[(11)C]methoxy-4-methoxyphenyl)acetamide (3-[(11)C]8a) and 2-((6-amino-9H-purin-8-yl)thio)-N-(4-[(11)C]methoxy-3-methoxyphenyl)acetamide (4-[(11)C]8a), were prepared by O-[(11)C]methylation of their corresponding precursors with [(11)C]CH3OTf under basic condition (2N NaOH) and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [(11)C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 23min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 185-555GBq/μmol. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Partnerships panel: natural, resource partnerships: literature synthesis and research agenda

    Science.gov (United States)

    Steve Selin; Nancy Myers

    1995-01-01

    This paper presents a summary of an annotated bibliography on natural resource partnerships. Resource areas and management functions addressed in the partnership literature are examined. Partnership research is summarized and broken into categories including: Partnership outcomes, assessing the potential for partnerships, characteristics of successful partnerships,...

  20. Phonetic alignment for speech synthesis in under-resourced languages

    CSIR Research Space (South Africa)

    Van Niekerk, DR

    2009-09-01

    Full Text Available to a lack of resources and expertise necessary for large scale development. Under these circumstances many techniques toward accurate segmentation are not feasible and it is unclear which approaches should be followed. In this paper the authors...

  1. A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans

    Science.gov (United States)

    Wilkinson, Daniel J.; Franchi, Martino V.; Brook, Matthew S.; Narici, Marco V.; Williams, John P.; Mitchell, William K.; Szewczyk, Nathaniel J.; Greenhaff, Paul L.; Atherton, Philip J.

    2013-01-01

    Quantification of muscle protein synthesis (MPS) remains a cornerstone for understanding the control of muscle mass. Traditional [13C]amino acid tracer methodologies necessitate sustained bed rest and intravenous cannulation(s), restricting studies to ∼12 h, and thus cannot holistically inform on diurnal MPS. This limits insight into the regulation of habitual muscle metabolism in health, aging, and disease while querying the utility of tracer techniques to predict the long-term efficacy of anabolic/anticatabolic interventions. We tested the efficacy of the D2O tracer for quantifying MPS over a period not feasible with 13C tracers and too short to quantify changes in mass. Eight men (22 ± 3.5 yr) undertook one-legged resistance exercise over an 8-day period (4 × 8–10 repetitions, 80% 1RM every 2nd day, to yield “nonexercised” vs. “exercise” leg comparisons), with vastus lateralis biopsies taken bilaterally at 0, 2, 4, and 8 days. After day 0 biopsies, participants consumed a D2O bolus (150 ml, 70 atom%); saliva was collected daily. Fractional synthetic rates (FSRs) of myofibrillar (MyoPS), sarcoplasmic (SPS), and collagen (CPS) protein fractions were measured by GC-pyrolysis-IRMS and TC/EA-IRMS. Body water initially enriched at 0.16–0.24 APE decayed at ∼0.009%/day. In the nonexercised leg, MyoPS was 1.45 ± 0.10, 1.47 ± 0.06, and 1.35 ± 0.07%/day at 0–2, 0–4, and 0–8 days, respectively (∼0.05–0.06%/h). MyoPS was greater in the exercised leg (0–2 days: 1.97 ± 0.13%/day; 0–4 days: 1.96 ± 0.15%/day, P < 0.01; 0–8 days: 1.79 ± 0.12%/day, P < 0.05). CPS was slower than MyoPS but followed a similar pattern, with the exercised leg tending to yield greater FSRs (0–2 days: 1.14 ± 0.13 vs. 1.45 ± 0.15%/day; 0–4 days: 1.13 ± 0.07%/day vs. 1.47 ± 0.18%/day; 0–8 days: 1.03 ± 0.09%/day vs. 1.40 ± 0.11%/day). SPS remained unchanged. Therefore, D2O has unrivaled utility to quantify day-to-day MPS in humans and inform on short

  2. Synthesis and radioiodination of 1-(B-D-2-iodo-2-eoxyfuranoarabinosy1)-2-nitroimidazole (N-2-IAZA), a novel radio-tracer for tissue hypoxia imaging

    International Nuclear Information System (INIS)

    Beiki, D.; Weibe, L.I.; Kumar, P.

    2002-01-01

    Viable tumors cells that reside in hypoxic cellular environment are 3 times more resistant to ionizing radiation than oxygenated cells. A non-invasive approach to study the extent of hypoxia involves the use of radio-tracer that selectively accumulates in hypoxic cells and does not damage normal cells. Hypoxia-selective uptake of 5-a- [125 I] iodo azomycin arabinoside (5-a-IAZA) has been demonstrated in a number of patient with varying pathological disorders including cancer, diabetes, arthritis and peripheral vascular disease, making it the most widely studied hypoxia marker in clinical research. The primary alkyl iodide of 5-a-IAZA is much more susceptible to heterodendria than secondary iodides and the compound undergoes d iodination, which necessarily increases the radiation dose to the thyroid gland and also contributes to undesired background radioactivity in later time images 2. It is also known that 5-a- IAZA, is not transported by cellular nucleoside transporters 3, where as, many B-arabinosyl nucleosides are efficiently internalized by these transporters. The present study reports the synthesis of a novel iodo azomycin arabinoside (B-2-IAZA), which designed to be chemically more stable than 5-a-IAZA by reducing extent of deiodination and poli c cleavage of the nucleoside bond by introducing steric bulk near the site of hydrolysis to be a substrate for cellular trans-membrane transport. The previous method for the thesis of B - azomycin arabinoside involves direct coupling of benzylated sugar with thylin moiety. The disadvantages of this method are formation of a - anomers which is 5 times than B-Anomers and the low chemical yield. This investigation also describes the synthesis B- azomycin arabinoside by C-2, inversion of centrifugation of the corresponding B-nucleoside and the resulting change made it possible to obtain only one anomers (B-anomers) reasonable yield. Microwave-assisted radio halogenation of these compounds gave higher of relatively pure

  3. Synthesis and preclinical evaluation of the choline transport tracer deshydroxy-[18F]fluorocholine ([18F]dOC)

    International Nuclear Information System (INIS)

    Henriksen, G.; Herz, M.; Hauser, A.; Schwaiger, M.; Wester, H.-J.

    2004-01-01

    11 C-labeled choline ([ 11 C]CHO) and 18 F-fluorinated choline analogues have been demonstrated to be valuable tracers for in vivo imaging of neoplasms by means of positron emission tomography (PET). The objective of the present study was to evaluate whether deshydroxy-[ 18 F]fluorocholine, ([ 18 F]dOC), a non-metabolizable [ 18 F]fluorinated choline analogue, can serve as a surrogate for cholines that are able to be phosphorylated and thus allow PET-imaging solely by addressing the choline transport system. The specificity of uptake of [ 18 F]dOC was compared with that of [ 11 C]choline ([ 11 C]CHO) in cultured rat pancreatic carcinoma and PC-3 human prostate cancer cells in vitro. In addition, biodistribution of [ 18 F]dOC and [ 11 C]CHO was compared in AR42J- and PC-3 tumor bearing mice. The in vitro studies revealed that membrane transport of both compounds can be inhibited in a concentration dependent manner by similar concentrations of cold choline (IC 50 [ 18 F]dOC= 11 μM; IC 50 [ 11 C]CHO=13 μM. In vitro studies with PC-3 and AR42J cells revealed that the internalized fraction of [ 18 F]dOC after 5 min incubation time is comparable to that of [ 11 C]CHO, whereas the uptake of [ 11 C]CHO was superior after 20 min incubation time. As for [ 11 C]CHO, kidney and liver were also the primary sites of uptake for [ 18 F]dOC in vivo. Biodistribution data after simultaneous injection of both tracers into AR42J tumor bearing mice revealed slightly higher tumor uptake for [ 18 F]dOC at 10 min post-injection, whereas [ 11 C]CHO uptake was higher at later time points. In conclusion, [ 18 F]dOC is taken up into AR42J rat pancreatic carcinoma and PC-3 human prostate cancer cells by a choline specific transport system. Similar transport rates of [ 18 F]dOC and [ 11 C]CHO result in comparable cellular uptake levels at early time points. In contrast to [ 18 F]dOC, which is transported but not intracellularily trapped, the choline kinase substrate [ 11 C]CHO is transported

  4. California GAMA Special Study: Analysis of Carbamazepine, Oxcarbazepine and Metabolites as Wastewater Tracers in Water Resource Studies

    Energy Technology Data Exchange (ETDEWEB)

    Owens, J. E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vu, A. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Esser, B. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-08-20

    The Groundwater Ambient Monitoring and Assessment (GAMA) Program is a comprehensive groundwater quality monitoring program managed by the California State Water Resources Control Board (SWRCB). The GAMA Special Studies project provides analyses and interpretation of constituents of concern that allow assessment of current groundwater conditions. In addition, the Special Studies project develops analyses that will enhance the monitoring and assessment effort by focusing on specific constituents of concern and water quality parameters, such as disinfection byproducts (DBP), wastewater indicators, and redox conditions, as it relates to irrigation and groundwater management. This study developed a robust analytical method for the quantitation of CBZ, OXC, CBZ-E, CBZ-DiOH, and CBZ-10-OH in wastewater treatement plant (WWTP) effluent and in groundwater in the parts per trillion range.

  5. Food resources of stream macroinvertebrates determined by natural-abundance stable C and N isotopes and a 15N tracer addition

    Science.gov (United States)

    Patrick J. Mulholland; Jennifer L. Tank; Diane M. Sanzone; Wilfrid M. Wollheim; Bruce J. Peterson; Jackson R. Webster; Judy L. Meyer

    2000-01-01

    Trophic relationships were examined using natural-abundance 13C and 15N analyses and a 15N-tracer addition experiment in Walker Branch, a 1st-order forested stream in eastern Tennessee. In the 15N-tracer addition experiment, we added 15NH4...

  6. Rapeseed Oil as Renewable Resource for Polyol Synthesis

    Science.gov (United States)

    Stirna, Uldis; Fridrihsone, Anda; Misane, Marija; Vilsone, Dzintra

    2011-01-01

    Vegetable oils are one of the most important platform chemicals due to their accessibility, specific structure of oils and low price. Rapeseed oil (RO) polyols were prepared by amidization of RO with diethanolamine (DEA). To determine the kinetics of amidization reaction, experiments were carried out. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), amine (NH) value was determined. Group contribution method by Fedor‵s was used to calculate solubility parameters, van der Waals volume was calculated by Askadskii. Obtained polyol‵s OH and NH value are from 304 up to 415 mg KOH/g. RO polyols synthesis meets the criteria of "green chemistry". In the present study, reaction of RO amidization with DEA was investigated, as well as optimum conditions for polyol synthesis was established to obtain polyols for polyurethane production. Calculations of solubility parameter and cohesion energy density were calculated, as RO polyols will be used as side chains in polymers, and solubility parameter will be used to explain properties of polymers.

  7. Biological activity determination of I-BSP, a potent MMP 2 inhibitor, and its 123I tracer synthesis

    International Nuclear Information System (INIS)

    Oltenfreiter, R.; Staelens, L.; Slegers, G.; Lejeune, A.; Frankenne, F.; Dierckx, R.A.

    2002-01-01

    Aim: Matrix metalloproteinases (MMPs) are a family of at least 18 secreted and membrane-bound zinc endopeptidases. Collectively they function in the degradation of extracellular matrix proteins and play an important role in both normal and pathological tissue remodelling. Increased MMP activity is detected in a wide range of cancers and seems to be correlated to their invasive and metastatic potential. MMPs thus seem an attractive target for both diagnostic (SPECT tracer) and therapeutic purposes. Therefore, we synthesised a 123 I-labelled MMP 2 inhibitor and evaluated it in vitro. Materials and methods: The 123 I-labelled compound was synthesised by a Cu-assisted nucleophilic non-isotopic exchange starting from Br-BSP. After reaction, the mixture was purified by HPLC. IC 50 values were obtained by in vitro enzyme assays. A 1:1 mix between non-radiolabelled inhibitor (concentration range: 300 nM - 0.05 nM) and enzymes (MMP2, cMT1-MMP, cMT3-MMP) was incubated for 15 minutes at 37 0 C. The fluorescent substrate (Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2) was added and the increase of fluorescence versus time, due to the hydrolysis of substrate, was measured (GEMINI-XS, λ exc = 328 nm and λ em = 393nm). Initial velocities were calculated for different concentrations of inhibitor and the IC 50 values were then determined. Results: Radiochemical yield was 30% ±3%. Radiochemical purity was >95%. IC 50 values for inhibition of MMP2, cMT3-MMP and cMT1-MMP were 0.5 nM, 7.1 nM and 16.9 nM respectively. Conclusion: 123 I-BSP was synthesised with 30% ±3% yield. After HPLC the radiochemical purity was >95%. In vitro enzyme assays of I-BSP showed an inhibition of MMP2, cMT3-MMP and cMT1-MMP in the low nM range (0.5 nM, 7.1 nM and 16.9 nM respectively). In vivo studies (biodistribution, metabolizing) in mice will be performed in the near future

  8. Microfluidics without channels: highly-flexible synthesis on a digital-microfluidic chip for production of diverse PET tracers

    Energy Technology Data Exchange (ETDEWEB)

    Van Dam, Robert Michael [Univ. of California, Los Angeles, CA (United States)

    2010-09-01

    Positron emission tomography (PET) imaging is used for fundamental studies of living biological organisms and microbial ecosystems in applications ranging from biofuel production to environmental remediation to the study, diagnosis, and treatment monitoring of human disease. Routine access to PET imaging, to monitor biochemical reactions in living organisms in real time, could accelerate a broad range of research programs of interest to DOE. Using PET requires access to short-lived radioactive-labeled compounds that specifically probe the desired living processes. The overall aims of this project were to develop a miniature liquid-handling technology platform (called “microfluidics”) that increases the availability of diverse PET probes by reducing the cost and complexity of their production. Based on preliminary experiments showing that microfluidic chips can synthesis such compounds, we aimed to advance this technology to improve its robustness, increase its flexibility for a broad range of probes, and increase its user-friendliness. Through the research activities of this project, numerous advances were made; Tools were developed to enable the visualization of radioactive materials within microfluidic chips; Fundamental advances were made in the microfluidic chip architecture and fabrication process to increase its robustness and reliability; The microfluidic chip technology was shown to produce useful quantities of an example PET probes, and methods to further increase the output were successfully pursued; A “universal” chip was developed that could produce multiple types of PET probes, enabling the possibility of “on demand” synthesis of different probes; and Operation of the chip was automated to ensure minimal radiation exposure to the operator Based on the demonstrations of promising technical feasibility and performance, the microfluidic chip technology is currently being commercialized. It is anticipated that costs of microfluidic chips can be

  9. Assessment of surface water resources availability using catchment modelling and the results of tracer studies in the mesoscale Migina Catchment, Rwanda

    Science.gov (United States)

    Munyaneza, O.; Mukubwa, A.; Maskey, S.; Uhlenbrook, S.; Wenninger, J.

    2014-12-01

    In the present study, we developed a catchment hydrological model which can be used to inform water resources planning and decision making for better management of the Migina Catchment (257.4 km2). The semi-distributed hydrological model HEC-HMS (Hydrologic Engineering Center - the Hydrologic Modelling System) (version 3.5) was used with its soil moisture accounting, unit hydrograph, liner reservoir (for baseflow) and Muskingum-Cunge (river routing) methods. We used rainfall data from 12 stations and streamflow data from 5 stations, which were collected as part of this study over a period of 2 years (May 2009 and June 2011). The catchment was divided into five sub-catchments. The model parameters were calibrated separately for each sub-catchment using the observed streamflow data. Calibration results obtained were found acceptable at four stations with a Nash-Sutcliffe model efficiency index (NS) of 0.65 on daily runoff at the catchment outlet. Due to the lack of sufficient and reliable data for longer periods, a model validation was not undertaken. However, we used results from tracer-based hydrograph separation from a previous study to compare our model results in terms of the runoff components. The model performed reasonably well in simulating the total flow volume, peak flow and timing as well as the portion of direct runoff and baseflow. We observed considerable disparities in the parameters (e.g. groundwater storage) and runoff components across the five sub-catchments, which provided insights into the different hydrological processes on a sub-catchment scale. We conclude that such disparities justify the need to consider catchment subdivisions if such parameters and components of the water cycle are to form the base for decision making in water resources planning in the catchment.

  10. The optimization of 18F-nucleophilic fluorination reaction and its application in synthesis of VMAT2 imaging tracer: [18F]AV-133

    International Nuclear Information System (INIS)

    Liu Yajing; Zhu Lin; Karl, P.; Qu Wenchao

    2010-01-01

    Objective: The nucleophilic introduction of n.c.a. [ 18 F]F- into alkanes by nucleophilic reaction is the main method of preparing 18 F-labelled radiopharmaceuticals, and the efficient and rapid reaction is important in 18 F-labelled radiopharmaceuticals. Method: Using 2-(3-substitute propoxy)naphthalene as model compound, the optimal reaction condition was achieved by comparing the different [ 18 F]fluorination condition: 1)different leaving groups (-OTs, -I, -Br and -Cl), 2) different [ 18 F]fluorination catalysts (Kryptofix222/K 2 CO 3 and TBAHCO 3 ), 3) different reaction solvent (ACN, DMSO and DMF), 4) [ 18 F]fluorination temperature (40, 50 and 60 degree C) and 5) reaction time. The radiochemical yields were analyzed by TLC and HPLC. VMAT2 imaging tracer [ 18 F]AV-133 was synthesized under the optimal conditions. Results: From the experiment results, the reation activity was the highest when using -OTs as the leaving group, followed by -I and -Br, -Clunder the [ 18 F]fluorination condition of using K222/K 2 CO 3 as catalyst and ACN as solvent. And also, the radiochemical yield raised as the reaction time and temperature increased. The higher temperature, the shorter time to reach the equilibrium. When changing the solvent from ACN to DMSO, the radiochemical yields were increased. On the contrary, the radiochemical yields were decreasing by using DMF. Comparing the catalyst K222/K 2 CO 3 with TBAHCO 3 , the [ 18 F] fluorination of -OTs gave a higher radiochemical yield in the presence of K222/K 2 CO 3 . So the optimized [ 18 F]fluorination reaction condition was that choosing -OTs as the leaving group, the [ 18 F]fluorination reaction was efficient and gave higher radiochemical yield catalyzed by K222/K 2 CO 3 in DMSO at high temperature. [ 18 F]fluorination of AV-244 was found to provide the VMAT2 imaging tracer [ 18 F]AV-133 in 80 ± 2% radiochemical yield after reaction at 120 degree C for 3 min under optimized conditions. Conclusion: We have described an

  11. Educational Resources and Implementation of a Greek Sign Language Synthesis Architecture

    Science.gov (United States)

    Karpouzis, K.; Caridakis, G.; Fotinea, S.-E.; Efthimiou, E.

    2007-01-01

    In this paper, we present how creation and dynamic synthesis of linguistic resources of Greek Sign Language (GSL) may serve to support development and provide content to an educational multitask platform for the teaching of GSL in early elementary school classes. The presented system utilizes standard virtual character (VC) animation technologies…

  12. A synthesis of thermokarst lake water balance in high-latitude regions of North America from isotope tracers

    Science.gov (United States)

    MacDonald, Lauren A.; Wolfe, Brent B.; Turner, Kevin W.; Anderson, Lesleigh; Arp, Christopher D.; Birks, Jean; Bouchard, Frédéric; Edwards, Thomas W.D.; Farquharson, Nicole; Hall, Roland I.; McDonald, Ian; Narancic, Biljana; Ouimet, Chantal; Pienitz, Reinhard; Tondu, Jana; White, Hilary

    2017-01-01

    Numerous studies utilizing remote sensing imagery and other methods have documented that thermokarst lakes are undergoing varied hydrological transitions in response to recent climate changes, from surface area expansion to drainage and evaporative desiccation. Here, we provide a synthesis of hydrological conditions for 376 lakes of mainly thermokarst origin across high-latitude North America. We assemble surface water isotope compositions measured during the past decade at five lake-rich landscapes including Arctic Coastal Plain (Alaska), Yukon Flats (Alaska), Old Crow Flats (Yukon), northwestern Hudson Bay Lowlands (Manitoba), and Nunavik (Quebec). These landscapes represent the broad range of thermokarst environments by spanning gradients in meteorological, permafrost, and vegetation conditions. An isotope framework was established based on flux-weighted long-term averages of meteorological conditions for each lake to quantify water balance metrics. The isotope composition of source water and evaporation-to-inflow ratio for each lake were determined, and the results demonstrated a substantial array of regional and subregional diversity of lake hydrological conditions. Controls on lake water balance and how these vary among the five landscapes and with differing environmental drivers are assessed. Findings reveal that lakes in the Hudson Bay Lowlands are most vulnerable to evaporative desiccation, whereas those in Nunavik are most resilient. However, we also identify the complexity in predicting hydrological responses of these thermokarst landscapes to future climate change.

  13. Synthesis quality control and biodistribution of technetium-99m triamcinolone (99mTc-TA) complex: An inflammation tracer agent

    International Nuclear Information System (INIS)

    Rizvii, Faheem Askari; Naqvi, Syed Ali Raza; Mehdi, Muhammad; Roohi, Samina; Zahoor, Ameer Fawad; Khan, Zulfiqar Ali; Sohaib, Muhammad; Rasheed, Rashid

    2017-01-01

    In present study synthesis of 99m Tc-triamcinolone acetonide ( 99m Tc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99m Tc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99m Tc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99m Tc-TA complex uptake (8.44 ±1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99m Tc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99m Tc-TA complex could be further studied to identify the inflammation based diseases

  14. Materials Synthesis Of Barium Hexa ferrite Used Local Natural Resources

    International Nuclear Information System (INIS)

    Ridwan; Sulungbudi, Grace Tj.; Mujamilah

    2003-01-01

    The magnetic materials of barium hexa ferrites, Ba O.6Fe 2 O 3 successfully synthesized by powder metallurgy method used local natural resources from materials waste of steel fabrication (HSM, CRM), waste of polymer fabrication (LK) as well as iron sands (PBA). These waste as well as iron sands were the main resources of iron oxide, Fe 2 O 3 . The barium oxide used in this experiments are from BaCO 3 product of Merck, and BaCO 4 which is commercially available in the market as barite. Phase identification by x-ray diffraction technique show the synthesized magnetic materials are agreed with the available commercial product, (SUMI). The energy product maximum (BH) max measured by vibrating sample magnetometer (VSM) for the samples used HSM-, CRM- and BaCO 3 as basic materials are 1.141 MGOe and 1.136 MGOe while SUMI is 1.142 MGOe. However for the samples made from LK-, PBA- used of BaCO 3 or CRM- with barite, the energy product maximum (BH) max are relatively lower than commercial product

  15. Sustainable synthesis gas from biomass. A bridge to a sustainable supply of energy and resources

    International Nuclear Information System (INIS)

    Den Uil, H.; Van Ree, R.; Van der Drift, A.; Boerrigter, H.

    2004-04-01

    Synthesis gas is currently primarily used in the (petro)chemical industry and for the production of liquid fuels. Smaller amounts are being used for electricity and synthetic natural gas (=SNG) production. Finite fossil resources, the dependence on political instable regimes and the Kyoto-protocol are drivers for the attention for renewable synthesis gas. In this report the market for, production of, use of and economy of renewable synthesis gas are analysed. Current synthesis gas use is limited to about 3% of the Dutch primary energy consumption; worldwide this is about 2%. Driven by the targets for renewable energy and the wide range of possible uses, the market for renewable synthesis gas has a large potential. When using synthesis gas for the production of SNG, electricity, liquid fuels and chemicals, the Dutch market for renewable synthesis gas can be 150 PJ in 2010, doubling about every decade to 1500 PJ in 2040. SNG and electricity, together about 80%. To reach these market volumes, import of biomass will be required due to the limited availability of local biomass resources in the Netherlands. The specifications for synthesis gas are dependent on the application. For (petro)chemical use and the production of liquid fuels high H2 and CO concentrations are required, for SNG and electricity production high CH4 concentrations are preferred. Due to the different specifications the names synthesis gas and product gas are used in this study. The name synthesis gas is claimed for a large number of gasification processes under development. But only for a number of processes this claim is justified. The gasification temperature determines the type of gas produced. At high temperatures, above 1300C, synthesis gas is produced, at low temperatures, 700-1000C, so-called product gas is being produced. Entrained-flow gasification is the only possibility for large-scale synthesis gas production in one step. For this process the particle size of the feed has to be small

  16. Assessment of surface water resources availability using catchment modeling and the results of tracer studies in the meso-scale Migina Catchment, Rwanda

    Science.gov (United States)

    Munyaneza, O.; Mukubwa, A.; Maskey, S.; Wenninger, J.; Uhlenbrook, S.

    2013-12-01

    In the last couple of years, different hydrological research projects were undertaken in the Migina catchment (243.2 km2), a tributary of the Kagera river in Southern Rwanda. These projects were aimed to understand hydrological processes of the catchment using analytical and experimental approaches and to build a pilot case whose experience can be extended to other catchments in Rwanda. In the present study, we developed a hydrological model of the catchment, which can be used to inform water resources planning and decision making. The semi-distributed hydrological model HEC-HMS (version 3.5) was used with its soil moisture accounting, unit hydrograph, liner reservoir (for base flow) and Muskingum-Cunge (river routing) methods. We used rainfall data from 12 stations and streamflow data from 5 stations, which were collected as part of this study over a period of two years (May 2009 and June 2011). The catchment was divided into five sub-catchments each represented by one of the five observed streamflow gauges. The model parameters were calibrated separately for each sub-catchment using the observed streamflow data. Calibration results obtained were found acceptable at four stations with a Nash-Sutcliffe Model Efficiency of 0.65 on daily runoff at the catchment outlet. Due to the lack of sufficient and reliable data for longer periods, a model validation (split sample test) was not undertaken. However, we used results from tracer based hydrograph separation from a previous study to compare our model results in terms of the runoff components. It was shown that the model performed well in simulating the total flow volume, peak flow and timing as well as the portion of direct runoff and base flow. We observed considerable disparities in the parameters (e.g. groundwater storage) and runoff components across the five sub-catchments, that provided insights into the different hydrological processes at sub-catchment scale. We conclude that such disparities justify the need

  17. Terpene and dextran renewable resources for the synthesis of amphiphilic biopolymers.

    Science.gov (United States)

    Alvès, Marie-Hélène; Sfeir, Huda; Tranchant, Jean-François; Gombart, Emilie; Sagorin, Gilles; Caillol, Sylvain; Billon, Laurent; Save, Maud

    2014-01-13

    The present work shows the synthesis of amphiphilic polymers based on the hydrophilic dextran and the hydrophobic terpenes as renewable resources. The first step concerns the synthesis of functional terpene molecules by thiol-ene addition chemistry involving amino or carboxylic acid thiols and dihydromyrcenol terpene. The terpene-modified polysaccharides were subsequently synthesized by coupling the functional terpenes with dextran. A reductive amination step produced terpene end-modified dextran with 94% of functionalization, while the esterification step produced three terpene-grafted dextrans with a number of terpene units per dextran of 1, 5, and 10. The amphiphilic renewable grafted polymers were tested as emulsifiers for the stabilization of liquid miniemulsion of terpene droplets dispersed in an aqueous phase. The average hydrodynamic diameter of the stable droplets was observed at about 330 nm.

  18. Studies on the distribution of radioactivity in the organism during constant intravenous infusion of tracer amino acids and on the calculation of the rate of tissue protein synthesis in rats

    International Nuclear Information System (INIS)

    Simon, O.; Bergner, H.; Wolf, E.

    1978-01-01

    Male wistar rats (100 p body weight) were infused into the tail vein with 14 C-leucine and 14 C-lysine simultaneously for 0.5; 1.0; 2.0; 3.0; 4.5; 6.0 and 7.0 hours. At the end of the infusion the specific radioactivity was determined of the free leucine and lysine in the blood plasma, liver, M. gastrocnemius, small intestine, and colon as well as of the protein-bound leucine and lysine. In all the tissues tested the specific radioactivity of the free amino acids attained a plateau during the 6-hour and 7-hour infusions. The rate constants for the increase were calculated for each organ tested. The two amino acids used are suitable for calculating the fractional rate of protein synthesis in tissues. The values of the fractional rate of protein synthesis calculated on the basis of the 6-hour and 7-hour infusions were: 54+-7.7%/day for the liver, 9.4+-1.2%/day for the muscles, 89+-12.2%/day for the small intestine, and 42+-5.9%/day for the colon. The simultaneous application of two tracer amino acids is recommendable for estimating the precursor pool of the protein synthesis and the more accurate calculation of the rate of protein synthesis. (author)

  19. Fifty years of radiochemical tracers

    International Nuclear Information System (INIS)

    Evans, E.A.

    1992-01-01

    During the past 50 years radiochemical tracers, usually in the form of isotopically labelled organic compounds, have been essential tools to further advance our knowledge at the frontiers of a great variety of scientific developments in the life sciences. This plenary lecture reviews necessarily selected highlights in the synthesis and applications of such radiochemical tracers. Included are examples where important advances, made possible by using radiochemicals, have contributed to improving the quality of life on this planet. The principal radioisotopes involved, 14 C, 3 H, 35 S, 32 P, 125 I, are all relatively safe to handle and are commercially available at maximum theoretical specific activity (carrier free). The compounds labeled with these radioisotopes are used in many fields of research which include biosynthesis and biotechnology studies, cell biology, drug metabolism, clinical research and environmental applications, and are briefly reviewed. (author). 55 refs

  20. Packet Tracer network simulator

    CERN Document Server

    Jesin, A

    2014-01-01

    A practical, fast-paced guide that gives you all the information you need to successfully create networks and simulate them using Packet Tracer.Packet Tracer Network Simulator is aimed at students, instructors, and network administrators who wish to use this simulator to learn how to perform networking instead of investing in expensive, specialized hardware. This book assumes that you have a good amount of Cisco networking knowledge, and it will focus more on Packet Tracer rather than networking.

  1. Climate and Land Use Change Effects on Ecological Resources in Three Watersheds: A Synthesis Report (Final Report)

    Science.gov (United States)

    EPA announced the availability of the final report, Climate and Land-Use Change Effects on Ecological Resources in Three Watersheds: A Synthesis Report. This report provides a summary of climate change impacts to selected watersheds and recommendations for how to improv...

  2. Synthesis and preliminary evaluation of {sup 18}F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation

    Energy Technology Data Exchange (ETDEWEB)

    DeGrado, Timothy R. E-mail: trd@petsparc.mc.duke.edu; Wang Shuyan; Holden, James E.; Nickles, R. Jerome; Taylor, Michael; Stone, Charles K

    2000-04-01

    Interest remains strong for the development of a noninvasive technique for assessment of regional fatty acid oxidation rate in the myocardium. {sup 18}F-labeled 4-thia palmitate (FTP, 16-[{sup 18}F]fluoro-4-thia-hexadecanoic acid) has been synthesized and preliminarily evaluated as a metabolically trapped probe of myocardial fatty acid oxidation for positron emission tomography (PET). The radiotracer is synthesized by Kryptofix 2.2.2/K{sub 2}CO{sub 3} assisted nucleophilic radiofluorination of an iodo-ester precursor, followed by alkaline hydrolysis and by purification by reverse phase high performance liquid chromatography. Biodistribution studies in rats showed high uptake and long retention of FTP in heart, liver, and kidneys consistent with relatively high fatty acid oxidation rates in these tissues. Inhibition of carnitine palmitoyl-transferase-I caused an 80% reduction in myocardial uptake, suggesting the dependence of trapping on the transport of tracer into the mitochondrion. Experiments with perfused rat hearts showed that the estimates of the fractional metabolic trapping rate (FR) of FTP tracked inhibition of oxidation rate of palmitate with hypoxia, whereas the FR of the 6-thia analog 17-[{sup 18}F]fluoro-6-thia-heptadecanoic acid was insensitive to hypoxia. In vivo defluorination of FTP in the rat was evidenced by bone uptake of radioactivity. A PET imaging study with FTP in normal swine showed excellent myocardial images, prolonged myocardial retention, and no bone uptake of radioactivity up to 3 h, the last finding suggesting a species dependence for defluorination of the omega-labeled fatty acid. The results support further investigation of FTP as a potential PET tracer for assessing regional fatty acid oxidation rate in the human myocardium.

  3. Synthesis and preliminary evaluation of 18F-labeled 4-thia palmitate as a PET tracer of myocardial fatty acid oxidation

    International Nuclear Information System (INIS)

    DeGrado, Timothy R.; Wang Shuyan; Holden, James E.; Nickles, R. Jerome; Taylor, Michael; Stone, Charles K.

    2000-01-01

    Interest remains strong for the development of a noninvasive technique for assessment of regional fatty acid oxidation rate in the myocardium. 18 F-labeled 4-thia palmitate (FTP, 16-[ 18 F]fluoro-4-thia-hexadecanoic acid) has been synthesized and preliminarily evaluated as a metabolically trapped probe of myocardial fatty acid oxidation for positron emission tomography (PET). The radiotracer is synthesized by Kryptofix 2.2.2/K 2 CO 3 assisted nucleophilic radiofluorination of an iodo-ester precursor, followed by alkaline hydrolysis and by purification by reverse phase high performance liquid chromatography. Biodistribution studies in rats showed high uptake and long retention of FTP in heart, liver, and kidneys consistent with relatively high fatty acid oxidation rates in these tissues. Inhibition of carnitine palmitoyl-transferase-I caused an 80% reduction in myocardial uptake, suggesting the dependence of trapping on the transport of tracer into the mitochondrion. Experiments with perfused rat hearts showed that the estimates of the fractional metabolic trapping rate (FR) of FTP tracked inhibition of oxidation rate of palmitate with hypoxia, whereas the FR of the 6-thia analog 17-[ 18 F]fluoro-6-thia-heptadecanoic acid was insensitive to hypoxia. In vivo defluorination of FTP in the rat was evidenced by bone uptake of radioactivity. A PET imaging study with FTP in normal swine showed excellent myocardial images, prolonged myocardial retention, and no bone uptake of radioactivity up to 3 h, the last finding suggesting a species dependence for defluorination of the omega-labeled fatty acid. The results support further investigation of FTP as a potential PET tracer for assessing regional fatty acid oxidation rate in the human myocardium

  4. Novel low temperature synthesis of spinel nano-magnesium chromites from secondary resources

    Energy Technology Data Exchange (ETDEWEB)

    El-Sheikh, S.M., E-mail: selsheikh2001@gmail.com [Nanostructured Materials Laboratory, Advanced Material Department, Central Metallurgical R and D Institute (CMRDI), P.O. Box 78, Helwan, 11421 Cairo (Egypt); Rabbah, M., E-mail: mahmoud.rabah@ymail.com [Electrochemical and Chemical Treatment Laboratory, Minerals Department, Central Metallurgical R and D Institute (CMRDI), P.O. Box 78, Helwan, 11421 Cairo (Egypt)

    2013-09-20

    Graphical abstract: FE-SEM micrograph and TEM image of magnesium chromite sample heated at 500 °C. - Highlights: • No study has been reported to prepare spinel magnesium chromite form waste resources. • Novel low synthesis temperature of magnesium chromite. • Selective removal of Ca ions from industrial waste tannery solution is rarely reported. • The method applied is simple and safe. - Abstract: A novel low temperature method for synthesis of nano-crystalline magnesium chromites from the tannery waste solution was investigated. Magnesium and chromium hydroxides gel was co-precipitated at pH 8.5 using ammonia solution. MgCr{sub 2}O{sub 4} was obtained by heating the gel formed at different temperatures 300–500 °C for to 8 h. FT-IR, TG-DTG-DTA, FE-SEM and TEM were used to investigate the produced materials. XRD patterns of the primary oxides revealed the formation of amorphous oxide phase by heating at 300 °C. Heating at 400 °C produces nano-crystallite magnesium chromites partly having the structure MgCrO{sub 4} and mainly MgCr{sub 2}O{sub 4} and traces of Cr{sub 2}O{sub 3}{sup +} 500 °C MgCrO{sub 4} mostly decomposed into MgCr{sub 2}O{sub 4} structure{sub .} After 8 h of heating at 500 °C, Cr{sub 2}O{sub 3} completely disappeared. A high surface area about 42.6 m{sup 2}/g and mesoporous structure was obtained for the produced sample at 500 °C for 8 h. A thermodynamic model has been suggested to explain the findings.

  5. National Uranium Resource Evaluation. Groundwater prospecting for sandstone-type uranium deposits: the merits of mineral-solution equilibria versus single element tracer methods. Final report

    International Nuclear Information System (INIS)

    Chatham, J.R.; Wanty, R.B.; Langmuir, D.

    1981-02-01

    Groundwaters from aquifers in two different sandstone-type uranium mining districts in Texas and Wyoming were collected and chemically analyzed. The data were used to compare the merits of using the computed saturation state of the groundwater with respect to uranium minerals, to that of single-element tracers in the groundwater for geochemical prospecting. Chemical properties of the Texas waters were influenced locally by preferred groundwater flow within buried fluvial channel deposits; upward leakage of brines along growth faults into the aquifer; and the establishment of a redox interface (Eh = 0 volts) within the aquifer. Chemical characteristics of aquifer waters in Wyoming changed gradually downdip, reflecting regional homogeneity in groundwater flow and a more gradual downdip reduction of Eh values than in Texas. The most reliable indicator of reduced uranium ore in both study sites was the saturation state of groundwater with respect to uraninite or coffinite. For both minerals, this saturation state increased from 15 to 20 log units as reduced ore deposits were approached over distances of 3 to 4.5 km in both sites. Tyuyamunite and carnotite approached or exceeded saturation in some oxidized waters of the Texas site reflecting possible occurrences of these minerals. The radiogenic elements Ta and Rn were excellent indicators of ore directly within the deposits, where anomalous values were 2 to 3 orders of magnitude above background. Helium also increased near the ore, although anomalies were generally displaced in the direction of groundwater flow. Uranium and uranium isotope values did not individually pinpoint ore, but may be used together to classify groundwater samples in terms of their position relative to uranium mineralization

  6. Final Progress Report for Project Entitled: Quantum Dot Tracers for Use in Engineered Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Peter [Univ. of Utah, Salt Lake City, UT (United States); Bartl, Michael [Univ. of Utah, Salt Lake City, UT (United States); Reimus, Paul [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Williams, Mark [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mella, Mike [Univ. of Utah, Salt Lake City, UT (United States)

    2015-09-12

    The objective of this project was to develop and demonstrate a new class of tracers that offer great promise for use in characterizing fracture networks in EGS reservoirs. From laboratory synthesis and testing through numerical modeling and field demonstrations, we have demonstrated the amazing versatility and applicability of quantum dot tracers. This report summarizes the results of four years of research into the design, synthesis, and characterization of semiconductor nanocrystals (quantum dots) for use as geothermal tracers.

  7. Remote-controlled module-assisted synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine as tumor PET tracer using two different radiochemical routes

    International Nuclear Information System (INIS)

    Wang Mingwei; Yin Duanzhi; Zhang Lan; Zhou Wei; Wang Yongxian

    2006-01-01

    The positron-emitter fluorine-18 labeled amino acid O-(2-[ 18 F]fluoroethyl)-L-tyrosine ([ 18 F]FET) has shown very promising perspectives for brain tumor diagnosis with positron emission tomography (PET). There have been two existing preparation routes of [ 18 F]FET named direct nucleophilic radiofiuorination of protected L-tyrosine and radiofiuoroallcylation of unprotected L-tyrosine, respectively. A general module was designed specifically for the routine synthesis of [ 18 F]FET, which could be suitable for the present two chemical methods with simple modifications. The fluorinated intermediates and the final product were separated and purified using solid phase extraction (SPE) on the Sep-Pak silica plus cartridge instead of the time-consuming high performance liquid chromatography (HPLC) procedures. The total synthesis time was about 50-60 rain with good radiochemical yield (about 20-40%, no-decay-corrected) and good radiochemical purity (more than 97%) for both the synthetic methods. (authors)

  8. Fluorinated tracers for imaging cancer with positron emission tomography

    International Nuclear Information System (INIS)

    Couturier, Olivier; Chatal, Jean-Francois; Luxen, Andre; Vuillez, Jean-Philippe; Rigo, Pierre; Hustinx, Roland

    2004-01-01

    2-[ 18 F]fluoro-2-deoxy-d-glucose (FDG) is currently the only fluorinated tracer used in routine clinical positron emission tomography (PET). Fluorine-18 is considered the ideal radioisotope for PET imaging owing to the low positron energy (0.64 MeV), which not only limits the dose rate to the patient but also results in a relatively short range of emission in tissue, thereby providing high-resolution images. Further, the 110-min physical half-life allows for high-yield radiosynthesis, transport from the production site to the imaging site and imaging protocols that may span hours, which permits dynamic studies and assessment of potentially fairly slow metabolic processes. The synthesis of fluorinated tracers as an alternative to FDG was initially tested using nucleophilic fluorination of the molecule, as performed when radiolabelling with iodine-124 or bromide-76. However, in addition to being long, with multiple steps, this procedure is not recommended for bioactive molecules containing reactive groups such as amine or thiol groups. Radiochemical yields are also often low. More recently, radiosynthesis from prosthetic group precursors, which allows easier radiolabelling of biomolecules, has led to the development of numerous fluorinated tracers. Given the wide availability of 18 F, such tracers may well develop into important routine tracers. This article is a review of the literature concerning fluorinated radiotracers recently developed and under investigation for possible PET imaging in cancer patients. Two groups can be distinguished. The first includes ''generalist'' tracers, i.e. tracers amenable to use in a wide variety of tumours and indications, very similar in this respect to FDG. These are tracers for non-specific cell metabolism, such as protein synthesis, amino acid transport, nucleic acid synthesis or membrane component synthesis. The second group consists of ''specific'' tracers for receptor expression (i.e. oestrogens or somatostatin), cell

  9. Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Murillo L., E-mail: murillolongo@gmail.com [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen (Denmark); Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618–970 Botucatu SP (Brazil); Calabresi, Marcos F.; Quini, Caio; Matos, Juliana F.; Miranda, José R.A.; Saeki, Margarida J. [Instituto de Biociências, Universidade Estadual Paulista, CP 510, 18618–970 Botucatu SP (Brazil); Bordallo, Heloisa N. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen (Denmark)

    2015-03-01

    Alternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn–Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH = 3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system.

  10. Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel

    International Nuclear Information System (INIS)

    Martins, Murillo L.; Calabresi, Marcos F.; Quini, Caio; Matos, Juliana F.; Miranda, José R.A.; Saeki, Margarida J.; Bordallo, Heloisa N.

    2015-01-01

    Alternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn–Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH = 3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system

  11. Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel.

    Science.gov (United States)

    Martins, Murillo L; Calabresi, Marcos F; Quini, Caio; Matos, Juliana F; Miranda, José R A; Saeki, Margarida J; Bordallo, Heloisa N

    2015-03-01

    Alternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn-Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH=3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Synthesis and preliminary evaluation of [18F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo

    International Nuclear Information System (INIS)

    Zhang Mingrong; Tsuchiyama, Akio; Haradahira, Terushi; Furutsuka, Kenji; Yoshida, Yuichiro; Junko Noguchi, Takayo Kida; Irie, Toshiaki; Suzuki, Kazutoshi

    2002-01-01

    N-[ 18 F]Fluoroethyl-4-piperidyl acetate ([ 18 F]FEtP4A), an analog of [ 11 C]MP4A for mapping brain acetylcholineseterase (AchE) activity, was prepared by reacting 4-piperidyl acetate (P4A) with [ 18 F]fluoroethyl bromide ([ 18 F]FEtBr) using a newly developed automated system. Preliminary evaluation showed that the initial uptake of [ 18 F]FEtP4A in the mouse brain was > 8% injected dose/g tissue. The distribution pattern of [ 18 F]FEtP4A in the brain was striatum>cerebral cortex>cerebellum within 10-120 min post-injection, which reflected the distribution rank pattern of AchE activity in the brain. Moreover, chemical analysis of in vivo radioactive metabolites in the mouse brain indicated that 83% of [ 18 F]FEtP4A was hydrolyzed to N-[ 18 F]fluoroethyl-4-piperidinol ([ 18 F]FEtP4OH) after 1 min intravenous injection. From these results, [ 18 F]FEtP4A may become a promising PET tracer for mapping the AchE in vivo

  13. Characteristics of waste automotive glasses as silica resource in ferrosilicon synthesis.

    Science.gov (United States)

    Farzana, Rifat; Rajarao, Ravindra; Sahajwalla, Veena

    2016-02-01

    This fundamental research on end-of-life automotive glasses, which are difficult to recycle, is aimed at understanding the chemical and physical characteristics of waste glasses as a resource of silica to produce ferrosilicon. Laboratory experiments at 1550°C were carried out using different automotive glasses and the results compared with those obtained with pure silica. In situ images of slag-metal separation showed similar behaviour for waste glasses and silica-bearing pellets. Though X-ray diffraction (XRD) showed different slag compositions for glass and silica-bearing pellets, formation of ferrosilicon was confirmed. Synthesized ferrosilicon alloy from waste glasses and silica were compared by Raman, X-ray photoelectron spectroscopy and scanning electron microscopy (SEM) analysis. Silicon concentration in the synthesized alloys showed almost 92% silicon recovery from the silica-bearing pellet and 74-92% silicon recoveries from various waste glass pellets. The polyvinyl butyral (PVB) plastic layer in the windshield glass decomposed at low temperature and did not show any detrimental effect on ferrosilicon synthesis. This innovative approach of using waste automotive glasses as a silica source for ferrosilicon production has the potential to create sustainable pathways, which will reduce specialty glass waste in landfill. © The Author(s) 2015.

  14. Tracer attenuation in groundwater

    Science.gov (United States)

    Cvetkovic, Vladimir

    2011-12-01

    The self-purifying capacity of aquifers strongly depends on the attenuation of waterborne contaminants, i.e., irreversible loss of contaminant mass on a given scale as a result of coupled transport and transformation processes. A general formulation of tracer attenuation in groundwater is presented. Basic sensitivities of attenuation to macrodispersion and retention are illustrated for a few typical retention mechanisms. Tracer recovery is suggested as an experimental proxy for attenuation. Unique experimental data of tracer recovery in crystalline rock compare favorably with the theoretical model that is based on diffusion-controlled retention. Non-Fickian hydrodynamic transport has potentially a large impact on field-scale attenuation of dissolved contaminants.

  15. Isotopic marking and tracers

    International Nuclear Information System (INIS)

    Morel, F.

    1997-01-01

    The use of radioactive isotopes as tracers in biology has been developed thanks to the economic generation of the required isotopes in accelerators and nuclear reactors, and to the multiple applications of tracers in the life domain; the most usual isotopes employed in biology are carbon, hydrogen, phosphorus and sulfur isotopes, because these elements are present in most of organic molecules. Most of the life science knowledge appears to be dependent to the extensive use of nuclear tools and radioactive tracers; the example of the utilization of radioactive phosphorus marked ATP to study the multiple reactions with proteins, nucleic acids, etc., is given

  16. Suitability of tracers

    International Nuclear Information System (INIS)

    Klotz, D.

    1999-01-01

    Hydrological tracer techniques are a means of making statements on the direction and speed of underground water. One of the simpler tasks is to find out whether there is hydrological communication between two given points. This requires a determination of the direction of flow, which places less exacting demands on the properties of the tracer than does the task of determining the flow velocity of underground water. Tracer methods can serve to infer from flow velocity the distance (flow) velocity, which is defined as the ratio between the distance between two points located in flow direction and the actual time it takes water to flow from one to the other [de

  17. Improving Marine Ecosystem Models with Biochemical Tracers

    Science.gov (United States)

    Pethybridge, Heidi R.; Choy, C. Anela; Polovina, Jeffrey J.; Fulton, Elizabeth A.

    2018-01-01

    Empirical data on food web dynamics and predator-prey interactions underpin ecosystem models, which are increasingly used to support strategic management of marine resources. These data have traditionally derived from stomach content analysis, but new and complementary forms of ecological data are increasingly available from biochemical tracer techniques. Extensive opportunities exist to improve the empirical robustness of ecosystem models through the incorporation of biochemical tracer data and derived indices, an area that is rapidly expanding because of advances in analytical developments and sophisticated statistical techniques. Here, we explore the trophic information required by ecosystem model frameworks (species, individual, and size based) and match them to the most commonly used biochemical tracers (bulk tissue and compound-specific stable isotopes, fatty acids, and trace elements). Key quantitative parameters derived from biochemical tracers include estimates of diet composition, niche width, and trophic position. Biochemical tracers also provide powerful insight into the spatial and temporal variability of food web structure and the characterization of dominant basal and microbial food web groups. A major challenge in incorporating biochemical tracer data into ecosystem models is scale and data type mismatches, which can be overcome with greater knowledge exchange and numerical approaches that transform, integrate, and visualize data.

  18. Tracers Detect Aquifer Contamination

    National Research Council Canada - National Science Library

    Enfield, Carl

    1995-01-01

    The EPA's National Laboratory (NRMRL) at Ada, OK, along with the University of Florida and the University of Texas, have developed a tracer procedure to detect the amount of contamination in aquifer formations...

  19. Radio-isotopic tracers

    International Nuclear Information System (INIS)

    Wolfangel, R.G.

    1976-01-01

    The invention concerns the dispersions that may be used for preparing radio-isotopic tracers, technetium labelled dispersions, processes for preparing these dispersions and their use as tracers. Technetium 99m sulphur colloids are utilized as scintillation tracers to give a picture of the reticulo-endothelial system, particularly the liver and spleen. A dispersion is provided which only requires the addition of a radioactive nuclide to form a radioactively labelled dispersion that can be injected as a tracer. It is formed of a colloid of tin sulphur dispersed in an aqueous buffer solution. Such a reagent has the advantage of being safe and reliable and is easier to use. The colloid can be prepared more quickly since additions of several different reagents are avoided. There is no need to heat up and no sulphuretted hydrogen, which is a toxic gas, is used [fr

  20. Synthesis and evaluation of 1'-[[sup 18]F]fluorometoprolol as a potential tracer for the visualization of [beta]-adrenoceptors with PET

    Energy Technology Data Exchange (ETDEWEB)

    Groot, T.J. de; Waarde, A. van; Elsinga, P.H.; Visser, G.M.; Vaalburg, Willem (Groningen Univ. Hospital (Netherlands)); Brodde, O.-E. (Essen Univ. (Germany). Biochemisches Forschungslabor)

    1993-07-01

    ([+-])-1'[[sup 18]F]Fluorometoprol 4 was prepared from desisopropylmetoprolol and [[sup 18]F]fluoroisopropyl tosylate 2 with a radiochemical yield of 2% [corrected for decay to end of bombardment (EOB), synthesis time 90 min]. Synthon 2 was prepared from (S)-1,2-propanediol di(p-toluenesulfonate) in 45% radiochemical yield. Compound 4 shows in two in vitro assays a similar affinity at [beta]-adrenoceptors (about 0.3 [mu]M) as metroprolol 5, but with a slightly higher [beta][sub 1]/[beta][sub 2]-adrenoceptor selectivity ratio (48.6 vs 30.7). In vivo experiments with 4 showed almost no receptor-mediated uptake in the heart probably because the affinity of (fluoro)metoprolol for the [beta][sub 1]-adrenoceptors is too low for successful imaging. However, the in vitro experiments suggest that the fluoroisopropyl group is suitable for the synthesis of [[sup 18]F]fluorinated [beta][sub 1]-adrenergic receptor binding ligands. (Author).

  1. Synthesis of carbon-11-labeled 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine derivatives as new potential PET tracers for imaging of p38α mitogen-activated protein kinase.

    Science.gov (United States)

    Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang

    2014-08-15

    The reference standards methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (10a), methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (10b) and corresponding precursors 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (11a), methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (11b) were synthesized from methyl crotonate and 3-amino-4-methylbenzoic acid in multiple steps with moderate to excellent yields. The target tracer [(11)C]methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate ([(11)C]10a) and [(11)C]methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate ([(11)C]10b) were prepared from their corresponding precursors with [(11)C]CH3OTf under basic condition through O-[(11)C]methylation and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields at end of bombardment (EOB) with 185-555 GBq/μmol specific activity at end of synthesis (EOS). Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Tracer techniques in microelectronics

    International Nuclear Information System (INIS)

    Flachowsky, J.; Freyer, K.

    1981-01-01

    Tracer technique and neutron activation analysis are capable of measuring impurities in semiconductor material or on the semiconductor surface in a very low concentration range. The methods, combined with autoradiography, are also suitable to determine dopant distributions in silicon. However, both techniques suffer from certain inherent experimental difficulties and/or limitations which are discussed. Methods of tracer technique practicable in the semiconductor field are described. (author)

  3. Synthesis of the Sex Pheromone of the Tea Tussock Moth Based on a Resource Chemistry Strategy

    Directory of Open Access Journals (Sweden)

    Hong-Li Zhang

    2018-06-01

    Full Text Available Synthesis of the sex pheromone of the tea tussock moth in 33% overall yield over 10 steps was achieved. Moreover, the chiral pool concept was applied in the asymmetric synthesis. The synthesis used a chemical available on a large-scale from recycling of wastewater from the steroid industry. The carbon skeleton was constructed using the C4+C5+C8 strategy. Based on this strategy, the original chiral center was totally retained.

  4. Tracers and tracing methods

    International Nuclear Information System (INIS)

    Leclerc, J.P.

    2001-01-01

    The first international congress on 'Tracers and tracing methods' took place in Nancy in May 2001. The objective of this second congress was to present the current status and trends on tracing methods and their applications. It has given the opportunity to people from different fields to exchange scientific information and knowledge about tracer methodologies and applications. The target participants were the researchers, engineers and technologists of various industrial and research sectors: chemical engineering, environment, food engineering, bio-engineering, geology, hydrology, civil engineering, iron and steel production... Two sessions have been planned to cover both fundamental and industrial aspects: 1)fundamental development (tomography, tracer camera visualization and particles tracking; validation of computational fluid dynamics simulations by tracer experiments and numerical residence time distribution; new tracers and detectors or improvement and development of existing tracing methods; data treatments and modeling; reactive tracer experiments and interpretation) 2)industrial applications (geology, hydrogeology and oil field applications; civil engineering, mineral engineering and metallurgy applications; chemical engineering; environment; food engineering and bio-engineering). The program included 5 plenary lectures, 23 oral communications and around 50 posters. Only 9 presentations are interested for the INIS database

  5. Tracer applications in oil reservoirs in Brazil

    International Nuclear Information System (INIS)

    Moreira, R.M.; Ferreira Pinto, A.M.

    2004-01-01

    Radiotracer applications in oil reservoirs in Brazil started in 1997 at the request of the State Oil Company (Petrobras) at the Carmoplois oilfield. 1 Ci of HTO was injected in a regular five-spot plot and the results obtained were quite satisfactory. Shortly after this test one other request asked for distinguishing the contribution of different injection wells to a production well. It was then realized that other tracers should be available. As a first choice 35 SCN - has been selected since it could be produced at CDTN. An alternative synthesis path was defined which shortened post-irradiation manipulations. The tracer was tested in core samples and a field injection, simultaneously with HTO, was carried out at the Buracica field; again the HTO performed well but 35 SCN - showed up well ahead. Presently the HTO applications are being done on a routine basis. All in all, four tests were performed (some are still ongoing), and the detection limits for both 3 H and 35 S were optimized by refining the sample preparation stage. Lanthanide complexes used as activable tracers are also an appealing option, however core tests performed so far with La-, Ce- and Eu-EDTA indicated some delay of the tracer, so other complexants such as DOTA are to be tried in further laboratory tests and in a field application. Thus, a deeper understanding of their complexation chemistry and carefully conducted tests must be performed before lanthanide complexes can be qualified as reliable oil reservoir tracers. More recently, Petrobras has been asking for partitioning tracers intended for SOR measurement

  6. Wairakei tracer tests 1983

    International Nuclear Information System (INIS)

    McCabe, W.J.; Barry, B.J.

    1984-05-01

    Tracer tests, with and without, hot water reinjection into WK213 showed returns of tracer iodine-131; in wells in both the Waiora Valley and the eastern end of the field. The effect of reinjection at a rate of 200 cu. m/h was to reduce the arrived time from 15 to 7 days. Increasing the rate of reinjection into WK62 from 30 cu. m/h to 200 cu. m/h seemed to increase the initial velocity of the tracer wave and the distance it moved. However, returns were recorded only in the adjacent wells WK61 and WK63 with a very small, and three days delayed, response in WK43

  7. Perceptual evaluation of corpus-based speech synthesis techniques in under-resourced environments

    CSIR Research Space (South Africa)

    Van Niekerk, DR

    2009-11-01

    Full Text Available With the increasing prominence and maturity of corpus-based techniques for speech synthesis, the process of system development has in some ways been simplified considerably. However, the dependence on sufficient amounts of relevant speech data...

  8. Models for tracer flow

    International Nuclear Information System (INIS)

    Zuber, A.

    1983-01-01

    A review and discussion is given of mathematical models used for interpretation of tracer experiments in hydrology. For dispersion model, different initial and boundary conditions are related to different injection and detection modes. Examples of applications of various models are described and commented. (author)

  9. Xanthine tracers and their preparation

    International Nuclear Information System (INIS)

    Groman, E.V.; Cabelli, M.D.

    1980-01-01

    Compounds useful as tracers in the radioimmunoassay of xanthine derivatives such as theophylline and pharmacologically related drugs are described. They are substituted xanthines in which at least one substituted radical contains radioiodine. The tracers are made by linking radioiodinatable or preradioiodinated radicals to the xanthine derivative which is to be assayed. The tracers may be employed in known radioimmunoassay techniques. (author)

  10. Synthesis of (meth)acrylamide-based glycomonomers using renewable resources and their polymerization in aqueous systems

    NARCIS (Netherlands)

    Adharis, Azis; Vesper, Dennis; Koning, Nick; Loos, Katja

    2018-01-01

    In this work, we present the kinetically-controlled enzymatic synthesis of novel glycosyl-(meth)acrylamide monomers using [small beta]-glucosidase. Cellobiose served as the glycosyl donor in the enzyme catalyzed transglycosylation reaction and hydroxyl-alkyl (meth)acrylamides as the glycosyl

  11. Tracer tests Wairakei

    International Nuclear Information System (INIS)

    McCabe, W.J.; Manning, M.R.; Barry, B.J.

    1980-07-01

    The report summarises the radioactive tracer tests, using iodine-131 and bromine-82, made in the Wairakei geothermal field over the period 1978-80. Injection of tracer into three wells with strong cool water downflows at about 300-400m below ground level, produced strong rapid responses from the only deep wells feeding from about 800-1000m and lying in the south-westerly direction from the injection wells, i.e. parallel to the fault planes. Shallower wells, even though in some cases much closer to the injection well, reacted much more slowly. Velocities, as measured by peak arrival times, as high as 22m/h over 200m and 11m/h over 650m, were found. The flow patterns for the cool water feeds to the production area are discussed

  12. Radioactive tracers in Sedimentology

    International Nuclear Information System (INIS)

    Rodrigues, H.T.

    1973-01-01

    First is given a broad description of the uses of radioactive tracers in Sedimentology. The general method is established, including determinations of probability and standard deviation. Following are determined: the response law of the detector, the minimum mass for statistical detection, and the minimum mass for dynamic detection. The granularity is an important variable in these calculations. Final conclusions are given, and results are compared with existing theories

  13. Journal: Efficient Hydrologic Tracer-Test Design for Tracer ...

    Science.gov (United States)

    Hydrological tracer testing is the most reliable diagnostic technique available for the determination of basic hydraulic and geometric parameters necessary for establishing operative solute-transport processes. Tracer-test design can be difficult because of a lack of prior knowledge of the basic hydraulic and geometric parameters desired and the appropriate tracer mass to release. A new efficient hydrologic tracer-test design (EHTD) methodology has been developed to facilitate the design of tracer tests by root determination of the one-dimensional advection-dispersion equation (ADE) using a preset average tracer concentration which provides a theoretical basis for an estimate of necessary tracer mass. The method uses basic measured field parameters (e.g., discharge, distance, cross-sectional area) that are combined in functional relatipnships that descrive solute-transport processes related to flow velocity and time of travel. These initial estimates for time of travel and velocity are then applied to a hypothetical continuous stirred tank reactor (CSTR) as an analog for the hydrological-flow system to develop initial estimates for tracer concentration, tracer mass, and axial dispersion. Application of the predicted tracer mass with the hydraulic and geometric parameters in the ADE allows for an approximation of initial sample-collection time and subsequent sample-collection frequency where a maximum of 65 samples were determined to be necessary for descri

  14. Halon-1301, a new Groundwater Age Tracer

    Science.gov (United States)

    Beyer, Monique; van der Raaij, Rob; Morgenstern, Uwe; Jackson, Bethanna

    2015-04-01

    Groundwater dating is an important tool to assess groundwater resources in regards to direction and time scale of groundwater flow and recharge and to assess contamination risks and manage remediation. To infer groundwater age information, a combination of different environmental tracers, such as tritium and SF6, are commonly used. However ambiguous age interpretations are often faced, due to a limited set of available tracers and limitations of each tracer method when applied alone. There is a need for additional, complementary groundwater age tracers. We recently discovered that Halon-1301, a water soluble and entirely anthropogenic gaseous substance, may be a promising candidate [Beyer et al, 2014]. Halon-1301 can be determined along with SF6, SF5CF3 and CFC-12 in groundwater using a gas chromatography setup with attached electron capture detector developed by Busenberg and Plummer [2008]. Halon-1301 has not been assessed in groundwater. This study assesses the behaviour of Halon-1301 in water and its suitability as a groundwater age tracer. We determined Halon-1301 in 17 groundwater and various modern (river) waters sites located in 3 different groundwater systems in the Wellington Region, New Zealand. These waters have been previously dated with tritium, CFC-12, CFC-11 and SF6 with mean residence times ranging from 0.5 to over 100 years. The waters range from oxic to anoxic and some show evidence of CFC contamination or degradation. This allows us to assess the different properties affecting the suitability of Halon-1301 as groundwater age tracer, such as its conservativeness in water and local contamination potential. The samples are analysed for Halon-1301 and SF6simultaneously, which allows identification of issues commonly faced when using gaseous tracers such as contamination with modern air during sampling. Overall we found in the assessed groundwater samples Halon-1301 is a feasible new groundwater tracer. No sample indicated significantly elevated

  15. Tracers and Tracer Testing: Design, Implementation, Tracer Selection, and Interpretation Methods

    Energy Technology Data Exchange (ETDEWEB)

    G. Michael Shook; Shannon L.; Allan Wylie

    2004-01-01

    Conducting a successful tracer test requires adhering to a set of steps. The steps include identifying appropriate and achievable test goals, identifying tracers with the appropriate properties, and implementing the test as designed. When these steps are taken correctly, a host of tracer test analysis methods are available to the practitioner. This report discusses the individual steps required for a successful tracer test and presents methods for analysis. The report is an overview of tracer technology; the Suggested Reading section offers references to the specifics of test design and interpretation.

  16. Heat tracer methods

    Science.gov (United States)

    Healy, Richard W.; Scanlon, Bridget R.

    2010-01-01

    The flow of heat in the subsurface is closely linked to the movement of water (Ingebritsen et al., 2006). As such, heat has been used as a tracer in groundwater studies for more than 100 years (Anderson, 2005). As with chemical and isotopic tracers (Chapter 7), spatial or temporal trends in surface and subsurface temperatures can be used to infer rates of water movement. Temperature can be measured accurately, economically, at high frequencies, and without the need to obtain water samples, facts that make heat an attractive tracer. Temperature measurements made over space and time can be used to infer rates of recharge from a stream or other surface water body (Lapham, 1989; Stonestrom and Constantz, 2003); measurements can also be used to estimate rates of steady drainage through depth intervals within thick unsaturated zones (Constantz et al., 2003; Shan and Bodvarsson, 2004). Several thorough reviews of heat as a tracer in hydrologic studies have recently been published (Constantz et al., 2003; Stonestrom and Constantz, 2003; Anderson, 2005; Blasch et al., 2007; Constantz et al., 2008). This chapter summarizes heat-tracer approaches that have been used to estimate recharge.Some clarification in terminology is presented here to avoid confusion in descriptions of the various approaches that follow. Diffuse recharge is that which occurs more or less uniformly across large areas in response to precipitation, infiltration, and drainage through the unsaturated zone. Estimates of diffuse recharge determined using measured temperatures in the unsaturated zone are referred to as potential recharge because it is possible that not all of the water moving through the unsaturated zone will recharge the aquifer; some may be lost to the atmosphere by evaporation or plant transpiration. Estimated fluxes across confining units in the saturated zone are referred to as interaquifer flow (Chapter 1). Focused recharge is that which occurs directly from a point or line source, such

  17. Multiyear Synthesis of Limnological Data from 1993 to 2001 for the Long Term Resource Monitoring Program

    National Research Council Canada - National Science Library

    Houser, Jeffrey N; Bierman, David W; Burdis, Robert M; Fischer, James R; Rogala, James T; Soeken-Gittinger, Lori A; Hoff, Kraig L; Harms, Erik

    2005-01-01

    .... The Long Term Resource Monitoring Program (LTRMP) provides a systemic perspective through the collection and analysis of monitoring data from six study reaches representing the upper, lower, and open river reaches of the UMRS...

  18. Development of radioisotope tracer technology

    International Nuclear Information System (INIS)

    Jin, Joon Ha; Lee, Myun Joo; Jung, Sung Hee; Park, Soon Chul; Lim, Dong Soon; Kim, Jae Ho; Lee, Jae Choon; Lee, Doo Sung; Cho, Yong Suk; Shin, Sung Kuan

    2000-04-01

    The purpose of this study is to develop the radioisotope tracer technology, which can be used in solving industrial and environmental problems and to build a strong tracer group to support the local industries. In relation to the tracer technology in 1999, experiments to estimate the efficiencies of a sludge digester of a waste water treatment plant and a submerged biological reactor of a dye industry were conducted. As a result, the tracer technology for optimization of facilities related to wastewater treatment has been developed and is believed to contribute to improve their operation efficiency. The quantification of the experimental result was attempted to improve the confidence of tracer technology by ECRIN program which basically uses the MCNP simulation principle. Using thin layer activation technique, wear of tappet shim was estimated. Thin layer surface of a tappet shim was irradiated by proton beam and the correlation between the measured activity loss and the amount of wear was established. The equipment was developed to adjust the energy of proton which collides with the surface of tappet. The tracer project team has participated into the tracer test for estimating the efficiency of RFCC system in SK cooperation. From the experiment the tracer team has obtained the primary elements to be considered for judging the efficiency of RFCC unit. By developing the tracer techniques to test huge industrial units like RFCC, the tracer team will be able to support the local industries that require technical services to solve any urgent trouble. (author)

  19. Chemical Tracer Methods: Chapter 7

    Science.gov (United States)

    Healy, Richard W.

    2017-01-01

    Tracers have a wide variety of uses in hydrologic studies: providing quantitative or qualitative estimates of recharge, identifying sources of recharge, providing information on velocities and travel times of water movement, assessing the importance of preferential flow paths, providing information on hydrodynamic dispersion, and providing data for calibration of water flow and solute-transport models (Walker, 1998; Cook and Herczeg, 2000; Scanlon et al., 2002b). Tracers generally are ions, isotopes, or gases that move with water and that can be detected in the atmosphere, in surface waters, and in the subsurface. Heat also is transported by water; therefore, temperatures can be used to trace water movement. This chapter focuses on the use of chemical and isotopic tracers in the subsurface to estimate recharge. Tracer use in surface-water studies to determine groundwater discharge to streams is addressed in Chapter 4; the use of temperature as a tracer is described in Chapter 8.Following the nomenclature of Scanlon et al. (2002b), tracers are grouped into three categories: natural environmental tracers, historical tracers, and applied tracers. Natural environmental tracers are those that are transported to or created within the atmosphere under natural processes; these tracers are carried to the Earth’s surface as wet or dry atmospheric deposition. The most commonly used natural environmental tracer is chloride (Cl) (Allison and Hughes, 1978). Ocean water, through the process of evaporation, is the primary source of atmospheric Cl. Other tracers in this category include chlorine-36 (36Cl) and tritium (3H); these two isotopes are produced naturally in the Earth’s atmosphere; however, there are additional anthropogenic sources of them.

  20. Novel tracer for radiation treatment planning

    International Nuclear Information System (INIS)

    Schwarzenboeck, S.; Krause, B.J.; Herrmann, K.; Gaertner, F.; Souvatzoglou, M.; Klaesner, B.

    2011-01-01

    PET and PET/CT with innovative tracers gain increasing importance in diagnosis and therapy management, and radiation treatment planning in radio-oncology besides the widely established FDG. The introduction of [ 18 F]Fluorothymidine ([ 18 F]FLT) as marker of proliferation, [ 18 F]Fluoromisonidazole ([ 18 F]FMISO) and [ 18 F]Fluoroazomycin-Arabinoside ([ 18 F]FAZA) as tracer of hypoxia, [ 18 F]Fluoroethyltyrosine ([ 18 F]FET) and [ 11 C]Methionine for brain tumour imaging, [ 68 Ga]DOTATOC for somatostatin receptor imaging, [ 18 F]FDOPA for dopamine synthesis and radioactively labeled choline derivatives for imaging phospholipid metabolism have opened novel approaches to tumour imaging. Some of these tracers have already been implemented into radio-oncology: Amino acid PET and PET/CT have the potential to optimise radiation treatment planning of brain tumours through accurate delineation of tumour tissue from normal tissue, necrosis and edema. Hypoxia represents a major therapeutic problem in radiation therapy. Hypoxia imaging is very attractive as it may allow to increase the dose in hypoxic tumours potentially allowing for a better tumour control. Advances in hybrid imaging, i.e. the introduction of MR/PET, may also have an impact in radio-oncology through synergies related to the combination of molecular signals of PET and a high soft tissue contrast of MRI as well as functional MRI capabilities. (orig.)

  1. Energy and resource basis of an Italian coastal resort region integrated using emergy synthesis.

    Science.gov (United States)

    Vassallo, Paolo; Paoli, Chiara; Tilley, David R; Fabiano, Mauro

    2009-10-01

    Sustainable development of coastal zones must balance economic development that encourages human visitation from a larger population with desires that differ from the local residents with the need to maintain opportunities for the local resident society and conserve ecological capital, which may serve as the basis for residents. We present a case study in which the sustainability level of a coastal zone (Riviera del Beigua), located along the Ligurian coast of north-western Italy, was assessed through the lens of systems ecology using emergy synthesis to integrate across economic, social and environmental sub-systems. Our purposes were (1) to quantify the environmental sustainability level of this coastal zone, (2) to evaluate the role of tourism in affecting the economy, society and environment, and (3) to compare emergy synthesis to Butler's Tourism Area Life Cycle model (TALC). Results showed that 81% of the total emergy consumption in the coastal zone was derived from external sources, indicating that this tourist-heavy community was not sustainable. Tourism, as the dominant economic sub-system, consumed 42% of the total emergy budget, while local residents used the remaining 58%. The progressive stages of the TALC model were found to parallel the dynamic changes in the ratio of external emergy inputs to local emergy inputs, suggesting that emergy synthesis could be a useful tool for detecting a tourist region's TALC stage. Use of such a quantitative tool could expedite sustainability assessment to allow administrative managers to understand the complex relationship between a region's economy, environment and resident society so sound policies can be developed to improve overall sustainability.

  2. A resource for developing an evidence synthesis report for policy-making

    DEFF Research Database (Denmark)

    Eklund Karlsson, Leena; Takahashi, Ryoko

    to public health questions by summarizing the best available global and local findings from peer-reviewed and grey literature, as well as policy options, and proposes general directions, strategies and actions for consideration. This resource has been developed to outline key approaches, methods...

  3. Lanthanide-based fluorescent tracers in complex media

    International Nuclear Information System (INIS)

    Brichart, Thomas

    2014-01-01

    Tracers are objects allowing the determination of the position or the distribution of a product; tracers are currently used in a great variety of domains. Despite the fact that each field has it's own specifications, it is possible to find tracers in medicine (contrast agents), anti-counterfeiting or geological exploration. We have developed lanthanide complex tracers for oil field injection waters. Those tracers, derived from the DOTA, have been detected at concentration lower than 1 ppb, thanks to a simple and compact apparatus. This detection has been made possible by the use of time-resolved fluorescence spectroscopy, this technique allows us to get rid of the background noise created by the intrinsic fluorescence of oil residues that are present in production waters. We also demonstrated how we can, through a reverse microemulsion synthesis, encapsulate several different dyes inside a single nanoparticle composed of a gold core and a silica shell. We showed as well, how those particles can be used as smart tracers to gather data, such as temperature, pH, solvents, etc. inside the well. Finally the use of lanthanides and scale inhibitors properties allowed us to create a simple and fast dosing protocol of such scale inhibitors in injection waters. This dosage will then allow the quick adjustment of their concentration inside each well. (author) [fr

  4. Radionuclides as tracers

    International Nuclear Information System (INIS)

    Ganatra, R.D.

    1992-01-01

    Importance of radioisotopes in medicine is because of their two characteristics: their biological behaviour is identical to their stable counterparts, and because they are radioactive their emissions can be detected by a suitable instrument. All isotopes of iodine will behave in the same way and will concentrate in the thyroid gland. There is no way of detecting the stable, natural iodine in the thyroid gland, but the presence of radioactive iodine can be detected externally in vivo by a detector. Thus, the radioactive iodine becomes a tracer, a sport of a spy, which mimics the behaviour of natural iodine and relays information to a detector. The radioactive tracers are popular because of the ease with which they can be detected in vivo and the fact that the measurement of their presence in the body can be in quantitative terms. The measurement can be very accurate and sensitive. Whenever the measurements can be done in vivo, the information is obtained in dynamic terms, as it is happening, as if the physiological events become transparent

  5. Construction and use of a three-dimensional model as a teaching resource for protein synthesis

    Directory of Open Access Journals (Sweden)

    Alberto Alexandre Lazzaroni

    2017-12-01

    Full Text Available A lot of biology topics are complex and abstract. So, the use of models that can simplify without trivializing knowledge, are important tools for the transposition of academic knowledge in school settings. By understanding the needs of its construction and, due to the lack of a concrete model that exemplifies the protein synthesis, the objective of this work was to elaborate this referred model. For this, the active teaching method was applied as a challenge proposal: the conception of a model conducted by High School students. Once the prototype was built, this strategy was applied to biology graduates, who evaluated and made some criticisms about it. Our results show that the tactic used   was effective. It was verified that the model should be reproduced and that its application facilitated learning of both high school students and undergraduates. We conclude that the availability of this model should contribute to the learning of biochemistry / molecular biology in formal education.

  6. Verification and controller synthesis for resource-constrained real-time systems

    DEFF Research Database (Denmark)

    Li, Shuhao; Pettersson, Paul

    2010-01-01

    -TIGA to check whether a given control objective can be enforced, and if so, we synthesize a controller for the system. We carry out a case study of this approach on a battery-powered autonomous truck. Experimental results indicate that the method is effective and computationally feasible.......An embedded system is often subject to timing constraints, resource constraints, and it should operate properly no matter how its environment behaves. This paper proposes to use timed game automata to characterize the timed behaviors and the environment uncertainties, and use piece-wise constant...... integer functions to approximate the continuous resources in real-time embedded systems. Based on these formal models and techniques, we employ the realtime model checker UPPAAL to verify a system against a given functional and/or timing requirement. Furthermore, we employ the timed game solver UPPAAL...

  7. Resilience design: toward a synthesis of cognition, learning, and collaboration for adaptive problem solving in conservation and natural resource stewardship

    Directory of Open Access Journals (Sweden)

    Charles G. Curtin

    2014-06-01

    Full Text Available Through the resilience design approach, I propose to extend the resilience paradigm by re-examining the components of adaptive decision-making and governance processes. The approach can be divided into three core components: (1 equity design, i.e., the integration of collaborative approaches to conservation and adaptive governance that generates effective self-organization and emergence in conservation and natural resource stewardship; (2 process design, i.e., the generation of more effective knowledge through strategic development of information inputs; and (3 outcome design, i.e., the pragmatic synthesis of the previous two approaches, generating a framework for developing durable and dynamic conservation and stewardship. The design of processes that incorporate perception and learning is critical to generating durable solutions, especially in developing linkages between wicked social and ecological challenges. Starting from first principles based on human cognition, learning, and collaboration, coupled with nearly two decades of practical experience designing and implementing ecosystem-level conservation and restoration programs, I present how design-based approaches to conservation and stewardship can be achieved. This context is critical in helping practitioners and resources managers undertake more effective policy and practice.

  8. The Synthesis of the Hierarchical Structure of Information Resources for Management of Electronic Commerce Entities

    Directory of Open Access Journals (Sweden)

    Krutova Anzhelika S.

    2017-06-01

    Full Text Available The aim of the article is to develop the theoretical bases for the classification and coding of economic information and the scientific justification of the content of information resources of an electronic commerce enterprise. The essence of information resources for management of electronic business entities is investigated. It is proved that the organization of accounting in e-commerce systems is advisable to be built on the basis of two circuits: accounting for financial flows and accounting associated with transformation of business factors in products and services as a result of production activities. There presented a sequence of accounting organization that allows to combine the both circuits in a single information system, which provides a possibility for the integrated replenishment and distributed simultaneous use of the e-commerce system by all groups of users. It is proved that the guarantee of efficient activity of the information management system of electronic commerce entities is a proper systematization of the aggregate of information resources on economic facts and operations of an enterprise in accordance with the management tasks by building the hierarchy of accounting nomenclatures. It is suggested to understand nomenclature as an objective, primary information aggregate concerning a certain fact of the economic activity of an enterprise, which is characterized by minimum requisites, is entered into the database of the information system and is to be reflected in the accounting system. It is proposed to build a database of e-commerce systems as a part of directories (constants, personnel, goods / products, suppliers, buyers and the hierarchy of accounting nomenclatures. The package of documents regulating the organization of accounting at an enterprise should include: the provision on the accounting services, the order on the accounting policy, the job descriptions, the schedules of information exchange, the report card and

  9. Radon as geological tracer

    Energy Technology Data Exchange (ETDEWEB)

    Lacerda, T.; Anjos, R.M. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Inst. de Fisica; Valladares, D.L.; Rizzotto, M.; Velasco, H.; Ayub, J. Juri [Universidad Nacional de San Luis (Argentina). Inst. de Matematica Aplicada San Luis (IMASL); Silva, A.A.R. da; Yoshimura, E.M. [Universidade de Sao Paulo (IF/USP), SP (Brazil). Inst. de Fisica

    2012-07-01

    Full text: This work presents measurements of {sup 222}Rn levels performed in La Carolina gold mine and Los Condores tungsten mine at the province of San Luis, Argentina, today used for tourist visitation, and can evaluate the potential use of such radioactive noble gas as tracer or marker for geological processes in underground environments. By concentrations of {sup 40}K, {sup 232}Th and {sup 23}'8U were also measured in the walls of tunnels were determined the rocks mineral composition, what indicated that the mines have the same composition. In this sense, we used nuclear trace plastic detectors CR-39, gamma spectrometry of rock samples and Geiger-Muller (GM) monitors The patterns of radon gas transportation processes revealed that La Carolina could be interpreted through a model based on a radioactive gas confined into a single entrance tube, with constant cross section and air velocity. Los Condores, which has a second main entrance, could be interpreted through a model based on a radioactive gas confined into a two entrance tube, allowing a chimney effect for air circulation. The results showed the high potential of using {sup 222}Rn as a geological tracer. In what concerns the occupational hazard, in summer (time of more intense tourist activity in the mine) La Carolina presented a mean concentration of the radioactive noble gas that exceeds in four times the action level of 1,5 kBq m{sup -3} recommended by the International Commission of Radiological Protection (ICRP). The chimney effect shows the low mean concentration of radon in Los Condores. (author)

  10. Radon as geological tracer

    International Nuclear Information System (INIS)

    Lacerda, T.; Anjos, R.M.; Silva, A.A.R. da; Yoshimura, E.M.

    2012-01-01

    Full text: This work presents measurements of 222 Rn levels performed in La Carolina gold mine and Los Condores tungsten mine at the province of San Luis, Argentina, today used for tourist visitation, and can evaluate the potential use of such radioactive noble gas as tracer or marker for geological processes in underground environments. By concentrations of 40 K, 232 Th and 23 '8U were also measured in the walls of tunnels were determined the rocks mineral composition, what indicated that the mines have the same composition. In this sense, we used nuclear trace plastic detectors CR-39, gamma spectrometry of rock samples and Geiger-Muller (GM) monitors The patterns of radon gas transportation processes revealed that La Carolina could be interpreted through a model based on a radioactive gas confined into a single entrance tube, with constant cross section and air velocity. Los Condores, which has a second main entrance, could be interpreted through a model based on a radioactive gas confined into a two entrance tube, allowing a chimney effect for air circulation. The results showed the high potential of using 222 Rn as a geological tracer. In what concerns the occupational hazard, in summer (time of more intense tourist activity in the mine) La Carolina presented a mean concentration of the radioactive noble gas that exceeds in four times the action level of 1,5 kBq m -3 recommended by the International Commission of Radiological Protection (ICRP). The chimney effect shows the low mean concentration of radon in Los Condores. (author)

  11. Development of Models to Simulate Tracer Tests for Characterization of Enhanced Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Mark D.; Reimus, Paul; Vermeul, Vincent R.; Rose, Peter; Dean, Cynthia A.; Watson, Tom B.; Newell, D.; Leecaster, Kevin; Brauser, Eric

    2013-05-01

    A recent report found that power and heat produced from enhanced (or engineered) geothermal systems (EGSs) could have a major impact on the U.S energy production capability while having a minimal impact on the environment. EGS resources differ from high-grade hydrothermal resources in that they lack sufficient temperature distribution, permeability/porosity, fluid saturation, or recharge of reservoir fluids. Therefore, quantitative characterization of temperature distributions and the surface area available for heat transfer in EGS is necessary for the design and commercial development of the geothermal energy of a potential EGS site. The goal of this project is to provide integrated tracer and tracer interpretation tools to facilitate this characterization. This project was initially focused on tracer development with the application of perfluorinated tracer (PFT) compounds, non-reactive tracers used in numerous applications from atmospheric transport to underground leak detection, to geothermal systems, and evaluation of encapsulated PFTs that would release tracers at targeted reservoir temperatures. After the 2011 midyear review and subsequent discussions with the U.S. Department of Energy Geothermal Technology Program (GTP), emphasis was shifted to interpretive tool development, testing, and validation. Subsurface modeling capabilities are an important component of this project for both the design of suitable tracers and the interpretation of data from in situ tracer tests, be they single- or multi-well tests. The purpose of this report is to describe the results of the tracer and model development for simulating and conducting tracer tests for characterizing EGS parameters.

  12. Tracer dating and ocean ventilation

    International Nuclear Information System (INIS)

    Thiele, G.; Sarmiento, J.L.

    1990-01-01

    The interpretation of transient tracer observations depends on difficult to obtain information on the evolution in time of the tracer boundary conditions and interior distributions. Recent studies have attempted to circumvent this problem by making use of a derived quantity, age, based on the simultaneous distribution of two complementary tracers, such as tritium and its daughter, helium 3. The age is defined with reference to the surface such that the boundary condition takes on a constant value of zero. The authors use a two-dimensional model to explore the circumstances under which such a combination of conservation equations for two complementary tracers can lead to a cancellation of the time derivative terms. An interesting aspect of this approach is that mixing can serve as a source or sink of tracer based age. The authors define an idealized ventilation age tracer that is conservative with respect to mixing, and they explore how its behavior compares with that of the tracer-based ages over a range of advective and diffusive parameters

  13. Tracer research in process engineering

    International Nuclear Information System (INIS)

    Iller, E.

    1992-01-01

    The book is a review of modern applications of tracer techniques in chemical and process engineering studies. The next topics have been extensively presented: 1) media flow through apparatus; 2) the tracers in the study of media flow dynamics through apparatus; 3) mathematical interpretation of experimental data from impulse-response method; 4) the models of media flow through chemical reactors and apparatus; 5) radiotracers in mass transport study; 6) examples of practical applications of tracer methods in industrial objects. 84 refs, 96 figs, 31 tabs

  14. Tracer dispersion - experiment and CFD

    International Nuclear Information System (INIS)

    Zitny, R.

    2004-01-01

    Description of tracer distribution by means of dispersion models is a method successfully used in process engineering for fifty years. Application of dispersion models in reactor engineering for characterization of flows in column apparatus, heat exchangers, etc. is summarized and experimental tracer techniques as well as CFD methods for dispersion coefficients evaluation are discussed. Possible extensions of thermal axial dispersion model (ADM) and a core-wall ADM model suitable for description of tracer dispersion in laminar flows are suggested as well as CFD implementation as 1D finite elements. (author)

  15. Meteorological tracers in regional planning

    International Nuclear Information System (INIS)

    Mueller, K.H.

    1974-11-01

    Atmospheric tracers can be used as indicators to study both the ventilation of an urban region and its dispersion meteorology for air pollutants. A correlation analysis applied to the space-time dependent tracer concentrations is able to give transfer functions, the structure and characteristic parameters of which describe the meteorological and topographical situation of the urban region and its surroundings in an integral manner. To reduce the number of persons usually involved in a tracer experiment an automatic air sampling system had to be developed

  16. Proceedings of the atmospheric tracers and tracer application workshop

    International Nuclear Information System (INIS)

    Barr, S.; Gedayloo, T.

    1979-12-01

    In addition to presentations by participating members a general discussion was held in order to summarize and outline the goals and objectives of the workshop. A number of new low level background tracers such as heavy methanes, perfluorocarbons, multiply labeled isotopes such as 13 C 18 O 2 , helium 3, in addition to sample collection techniques and analytical methods for various tracers were discussed. This report is a summary of discussions and papers presented at this workshop

  17. Novel tracer for radiation treatment planning; Welche neuen PET-Tracer braucht die Strahlentherapie?

    Energy Technology Data Exchange (ETDEWEB)

    Schwarzenboeck, S.; Krause, B.J. [Rostock Univ. (Germany). Klinik fuer Nuklearmedizin; Herrmann, K.; Gaertner, F.; Souvatzoglou, M. [Technische Univ. Muenchen (Germany). Klinik fuer Nuklearmedizin; Klaesner, B. [Klinikum Bogenhausen, Muenchen (Germany). Inst. fuer Radiologie und Nuklearmedizin

    2011-07-15

    PET and PET/CT with innovative tracers gain increasing importance in diagnosis and therapy management, and radiation treatment planning in radio-oncology besides the widely established FDG. The introduction of [{sup 18}F]Fluorothymidine ([{sup 18}F]FLT) as marker of proliferation, [{sup 18}F]Fluoromisonidazole ([{sup 18}F]FMISO) and [{sup 18}F]Fluoroazomycin-Arabinoside ([{sup 18}F]FAZA) as tracer of hypoxia, [{sup 18}F]Fluoroethyltyrosine ([{sup 18}F]FET) and [{sup 11}C]Methionine for brain tumour imaging, [{sup 68}Ga]DOTATOC for somatostatin receptor imaging, [{sup 18}F]FDOPA for dopamine synthesis and radioactively labeled choline derivatives for imaging phospholipid metabolism have opened novel approaches to tumour imaging. Some of these tracers have already been implemented into radio-oncology: Amino acid PET and PET/CT have the potential to optimise radiation treatment planning of brain tumours through accurate delineation of tumour tissue from normal tissue, necrosis and edema. Hypoxia represents a major therapeutic problem in radiation therapy. Hypoxia imaging is very attractive as it may allow to increase the dose in hypoxic tumours potentially allowing for a better tumour control. Advances in hybrid imaging, i.e. the introduction of MR/PET, may also have an impact in radio-oncology through synergies related to the combination of molecular signals of PET and a high soft tissue contrast of MRI as well as functional MRI capabilities. (orig.)

  18. Tracer studies with aortic infusion result in improper tracer distribution

    International Nuclear Information System (INIS)

    Wisneski, J.A.; Brooks, G.A.; Neese, R.A.; Stanley, W.C.; Morris, D.L.; Gertz, E.W.

    1986-01-01

    It has been suggested that lactate turnover can be accurately assessed by infusing radioactive lactate tracer into the aorta and sampling blood in the vena cava. However, there may be streaming of newly infused tracer in the aorta, resulting in a nonuniform arterial specific activity (SA). Furthermore vena caval blood may not be representative of mixed venous blood. The authors examined this problem in 7 anesthetized dogs with sampling catheters in the pulmonary (PA), carotid (CA), and femoral (FA) arteries, and the superior (SVC) and inferior (IVC) vena cavi. [1- 14 C]lactate was continuously infused into the left ventricle through a catheter introduced through the femoral artery. The same SA (dpm/μmol) was found in the CA and FA, indicating adequate mixing of newly infused tracer with trace. Three dogs showed differences between SVC, IVC and PA, suggesting a mixed venous sample can not be obtained from the VC. When the catheter was moved into the aorta, wide differences in SA appeared between the CA and FA, clearly reflecting streaming of tracer. These differences also appeared in the SVC and IVC. In conclusion, adequate mixing does not occur between tracer and trace in arterial blood with aortic infusion. Further, VC sampling will not give a consistent mixed venous SA. Therefore, for practical reasons, aortic tracer infusion with vena caval sampling will lead to erroneous turnover values

  19. Tracer transport in fractured rocks

    International Nuclear Information System (INIS)

    Tsang, C.F.; Tsang, Y.W.; Hale, F.V.

    1988-07-01

    Recent interest in the safety of toxic waste underground disposal and nuclear waste geologic repositories has motivated many studies of tracer transport in fractured media. Fractures occur in most geologic formations and introduce a high degree of heterogeneity. Within each fracture, the aperture is not constant in value but strongly varying. Thus for such media, tracer tends to flow through preferred flowpaths or channels within the fractures. Along each of these channels, the aperture is also strongly varying. A detailed analysis is carried out on a 2D single fracture with variable apertures and the flow through channels is demonstrated. The channels defined this way are not rigidly set pathways for tracer transport, but are the preferred flow paths in the sense of stream-tubes in the potential theory. It is shown that such variable-aperture channels can be characterized by an aperture probability distribution function, and not by the exact deterministic geometric locations. We also demonstrate that the 2D tracer transport in a fracture can be calculated by a model of a system of 1D channels characterized by this distribution function only. Due to the channeling character of tracer transport in fractured rock, random point measurements of tracer breakthrough curves may give results with a wide spread in value due to statistical fluctuations. The present paper suggests that such a wide spread can probably be greatly reduced by making line/areal (or multiple) measurements covering a few spatial correlation lengths. 13 refs., 11 figs., 1 tab

  20. Measurement of open streams by using tracers

    International Nuclear Information System (INIS)

    Ramos, German F.; Tarquino, W.; Curcuy, H.; Orozco, C.

    1999-01-01

    This paper presents an intercomparison study to be carried out between flux measurements by using tracers and moulinet. This intercomparison is scheduled to be performed at the measurement station belonging to the National Service of Meteorology and Hydrology (SENAMHI). Two techniques of tracer dilution are outstanded: total evaluation with tracer punctual injection and punctual evaluation with tracer continuous injection. Total evaluation with tracer punctual injection has been used since this technique is considered to be more suitable for hydrology purposes

  1. Radioactive tracers in the sea

    International Nuclear Information System (INIS)

    Jenkins, W.J.; Livingston, H.D.

    1980-01-01

    Artificial radionuclides introduced to the oceans during the last four decades have proved invaluable tools for study of many processes in marine water columns and sediments. Both global and close-in fallout of radioactivity from atmospheric nuclear weapons testing have distributed these radionuclides widely, and in amounts sufficient to be useful as tracers. An additional source of considerable significance and tracer potential comes from coastal discharges of European nuclear fuel reprocessing wastes. The nature of these sources, types and amounts of radionuclides introduced and the time histories of their introduction generate a variety of tracer distributions which illuminate a broad spectrum of physical and chemical processes active over a wide range of timescales. Depending on their respective chemistries, artificial radionuclides have been demonstrated to exhibit both conservative and non-conservative properties in the oceans. Some examples are given of the uses made of soluble, conservative tracers for the study of oceanic transport processes and of non-conservative tracers for studies of processes which move them to, and mix them within, marine sediments. Sampling and measurement techniques which have been used in these studies are described

  2. Radiochemical tracers in marine biology

    International Nuclear Information System (INIS)

    Petrocelli, S.R.; Anderson, J.W.; Neff, J.M.

    1977-01-01

    Tracers have been used in a great variety of experimentation. More recently, labeled materials have been applied in marine biological research. Some of the existing tracer techniques have been utilized directly, while others have been modified to suit the specific needs of marine biologists. This chapter describes some of the uses of tracers in marine biological research. It also mentions the problems encountered as well as offering possible solutions and discusses further applications of these techniques. Only pertinent references are cited and additional information may be obtained by consulting these references. Due to their relative ease of maintenance, freshwater species are also utilized in studies which involve radiotracer techniques. Since most of these techniques e directly applicable to marine species, some of these studies will also be included

  3. Radioisotope tracer applications in industry

    International Nuclear Information System (INIS)

    Rao, S.M.

    1987-01-01

    Radioisotope tracers have many advantages in industrial trouble-shooting and studies on process kinetics. The applications are mainly of two types: one leading to qualitative (Yes or No type) information and the other to quantitative characterisation of flow processes through mass balance considerations and flow models. ''Yes or No'' type methods are mainly used for leakage and blockage locations in pipelines and in other industrial systems and also for location of water seepage zones in oil wells. Flow measurements in pipelines and mercury inventory in electrolytic cells are good examples of tracer methods using the mass balance approach. Axial dispersion model and Tanks-in-Series model are the two basic flow models commonly used with tracer methods for the characterisation of kinetic processes. Examples include studies on flow processes in sugar crystallisers as well as in a precalcinator in a cement plant. (author). 18 figs

  4. Tracers of cancer cells in nuclear oncology

    International Nuclear Information System (INIS)

    Tamgac, F.; Baillet, G.; Moretti, J.L.; Safi, N.; Weinmann, P.; Beco, V. de

    1997-01-01

    Evaluating the extent of disease is important in planning cancer treatment. Different types of tracers are used in vivo to diagnose tumors and these tracers can give supplementary information on the differentiation degree of tumors and response to therapy. (authors)

  5. Atmospheric tracer experiments for regional dispersion studies

    International Nuclear Information System (INIS)

    Heffter, J.L.; Ferber, G.J.

    1980-01-01

    Tracer experiments are being conducted to verify atmospheric transport and dispersion calculations at distances from tens to hundreds of km from pollutant sources. In one study, a 2 1/2 year sampling program has been carried out at 13 sites located 30 to 140 km from a source of 85 Kr at the Savannah River Plant in South Carolina. Average weekly concentrations as well as twice-daily concentrations were obtained. Sampling data and meteorological data, including surface, tower, and rawinsonde observations are available on magnetic tape for model verification studies. Some verification results for the Air Resources Laboratories Atmospheric Transort and Dispersion Model (ARL-ATAD) are shown for averaging periods from one week to two years

  6. Thiocyanate use as radioactive tracer in a petroleum field

    International Nuclear Information System (INIS)

    Pereira, Elaine Henriques Teixeira; Souza, Fabiane Ferreira de; Pinto, Amenonia Maria Ferreira; Moreira, Rubens Martins

    2002-01-01

    Currently, most of the oil exploration in reservoirs is made out if the assistance of the injection of different fluids, waters in particular, to increase production. For this reason it has been largely spread the application of chemical and/or radioactive tracers in the study of the characteristics of transport of the injected fluid between injection and production wells. K 35 SCN is considered a good tracer due to its higher solubility in water and low adsorption. This work presents a brief review of the methods described in literature for obtain S-35. It was found out to be the most appropriate method the synthesis of thiocyanate starting from the reaction of KCN and S-35. It was also investigated the efficiency of the reaction for the obtention of KSCN. (author)

  7. Primordial helium abundance determination using sulphur as metallicity tracer

    Science.gov (United States)

    Fernández, Vital; Terlevich, Elena; Díaz, Angeles I.; Terlevich, Roberto; Rosales-Ortega, F. F.

    2018-05-01

    The primordial helium abundance YP is calculated using sulphur as metallicity tracer in the classical methodology (with YP as an extrapolation of Y to zero metals). The calculated value, YP, S = 0.244 ± 0.006, is in good agreement with the estimate from the Planck experiment, as well as, determinations in the literature using oxygen as the metallicity tracer. The chemical analysis includes the sustraction of the nebular continuum and of the stellar continuum computed from simple stellar population synthesis grids. The S+2 content is measured from the near infrared [SIII]λλ9069Å, 9532Å lines, while an ICF(S3 +) is proposed based on the Ar3 +/Ar2 + fraction. Finally, we apply a multivariable linear regression using simultaneously oxygen, nitrogen and sulphur abundances for the same sample to determine the primordial helium abundance resulting in YP - O, N, S = 0.245 ± 0.007.

  8. Tracer-tracer relations as a tool for research on polar ozone loss

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Rolf

    2010-07-01

    The report includes the following chapters: (1) Introduction: ozone in the atmosphere, anthropogenic influence on the ozone layer, polar stratospheric ozone loss; (2) Tracer-tracer relations in the stratosphere: tracer-tracer relations as a tool in atmospheric research; impact of cosmic-ray-induced heterogeneous chemistry on polar ozone; (3) quantifying polar ozone loss from ozone-tracer relations: principles of tracer-tracer correlation techniques; reference ozone-tracer relations in the early polar vortex; impact of mixing on ozone-tracer relations in the polar vortex; impact of mesospheric intrusions on ozone-tracer relations in the stratospheric polar vortex calculation of chemical ozone loss in the arctic in March 2003 based on ILAS-II measurements; (4) epilogue.

  9. Synthesis of O-[2-[18F]fluoro-3-(2-nitro-1H-imidazole-1-yl)propyl]tyrosine ([18F]FNT]) as a new class of tracer for imaging hypoxia

    International Nuclear Information System (INIS)

    Noeen Malik; Xian Lin; Christoph Solbach; Hans-Juergen Machulla; Bin Shen; Gerald Reischl; Wolfgang Voelter

    2012-01-01

    For detection of hypoxic tumor tissue, all radiotracers synthesized until now, are based on the concept that cellular uptake is being controlled by diffusion. As a new approach, we chose the concept to have the tracer hypothetically transported into the cells by well known carrier systems like the amino acid transporters. For this purpose, radiosynthesis of O-[2-[ 18 F]fluoro-3-(2-nitro-1H-imidazole-1yl)propyl]tyrosine ([18F]FNT]) was carried out from methyl 2-(benzyloxycarbonyl)-3-(4-3-(2-nitro-1H-imidazol-1-yl) -2-(tosyloxy)propoxy) phenyl)propanoate via no-carrier-added nucleophilic aliphatic substitution. After labelling, 81 ± 0.9% of labelled intermediate i.e. methyl 2-(benzyloxycarbonyl)-3-(4-(2-[ 18 F]fluoro-3- (2-nitro-1H-imidazole-1-yl)propoxy) phenyl)propanoate was obtained at 140 deg C. At the end of radiosynthesis, [ 18 F]FNT was obtained in an overall radiochemical yield of 40 ± 0.9% (not decay corrected) within 90 min in a radiochemical purity of >98% in a formulation ready for application in the clinical studies for PET imaging of hypoxia. (author)

  10. New SPECT tracers: Example of tracers of proteoglycans and melanin

    International Nuclear Information System (INIS)

    Cachin, F.; Mestas, D.; Kelly, A.; Merlin, C.; Veyre, A.; Maublant, J.; Cachin, F.; Chezal, J.M.; Miot-Noirault, E.; Moins, N.; Auzeloux, P.; Vidal, A.; Bonnet-Duquennoy, M.; Boisgard, S.; D'Incan, M.; Madelmont, J.C.; Maublant, J.; Boisgard, S.; D'Incan, M.; Redini, F.; Filaire, M.

    2009-01-01

    The majority of research program on new radiopharmaceuticals turn to tracers used for positron emission tomography (PET). Only a few teams work on new non fluorine labeled tracers. However, the coming of SPECT/CT gamma cameras, the arrival of semi-conductors gamma cameras should boost the development of non-PET tracers. We exhibit in this article the experience acquired by our laboratory in the conception and design of two new non fluorine labelled compounds. The 99m Tc-N.T.P. 15-5 (N.T.P. 15-5 for N-[tri-ethyl-ammonium]-3-propyl-[15]ane-N5) which binds to proteoglycans could be used for the diagnosis and staging of osteoarthritis and chondrosarcoma. The iodo benzamides, specific to the melanin, are nowadays compared to 18 F-fluorodeoxyglucose in a phase III clinical trial for the diagnosis and detection of melanoma metastasis. Our last development focus on N-[2-(diethyl-amino)ethyl]-4 and 2-iodo benzamides respectively B.Z.A. and B.Z.A.2 hetero-aromatic analogues usable for melanoma treatment. (authors)

  11. Complex functionality with minimal computation: Promise and pitfalls of reduced-tracer ocean biogeochemistry models

    Science.gov (United States)

    Galbraith, Eric D.; Dunne, John P.; Gnanadesikan, Anand; Slater, Richard D.; Sarmiento, Jorge L.; Dufour, Carolina O.; de Souza, Gregory F.; Bianchi, Daniele; Claret, Mariona; Rodgers, Keith B.; Marvasti, Seyedehsafoura Sedigh

    2015-12-01

    Earth System Models increasingly include ocean biogeochemistry models in order to predict changes in ocean carbon storage, hypoxia, and biological productivity under climate change. However, state-of-the-art ocean biogeochemical models include many advected tracers, that significantly increase the computational resources required, forcing a trade-off with spatial resolution. Here, we compare a state-of-the art model with 30 prognostic tracers (TOPAZ) with two reduced-tracer models, one with 6 tracers (BLING), and the other with 3 tracers (miniBLING). The reduced-tracer models employ parameterized, implicit biological functions, which nonetheless capture many of the most important processes resolved by TOPAZ. All three are embedded in the same coupled climate model. Despite the large difference in tracer number, the absence of tracers for living organic matter is shown to have a minimal impact on the transport of nutrient elements, and the three models produce similar mean annual preindustrial distributions of macronutrients, oxygen, and carbon. Significant differences do exist among the models, in particular the seasonal cycle of biomass and export production, but it does not appear that these are necessary consequences of the reduced tracer number. With increasing CO2, changes in dissolved oxygen and anthropogenic carbon uptake are very similar across the different models. Thus, while the reduced-tracer models do not explicitly resolve the diversity and internal dynamics of marine ecosystems, we demonstrate that such models are applicable to a broad suite of major biogeochemical concerns, including anthropogenic change. These results are very promising for the further development and application of reduced-tracer biogeochemical models that incorporate "sub-ecosystem-scale" parameterizations.

  12. Tracer techniques in food industry

    International Nuclear Information System (INIS)

    Pertsovskij, E.S.; Sakharov, Eh.V.; Dolinin, V.A.

    1980-01-01

    The appicability of radioactive tracer techniques to process control in food industry are considered. Investigations in the field of food industry carried out using the above method are classified. The 1 class included investigations with preliminary preparation of a radioactive indicator and its following introduction in the system studied. The 2 class includes investigations based on the introduction in the system studied of a non-active indicator which is activated in a neutron flux being in samples selected in or after the process investigated. The 3 class includes studies based on investigations of natural radioactivity of certain nuclides in food stuff. The application of tracer techniques to the above classes of investigations in various fields of food industry and the equipment applied are considered in detail [ru

  13. The Accurate Particle Tracer Code

    OpenAIRE

    Wang, Yulei; Liu, Jian; Qin, Hong; Yu, Zhi

    2016-01-01

    The Accurate Particle Tracer (APT) code is designed for large-scale particle simulations on dynamical systems. Based on a large variety of advanced geometric algorithms, APT possesses long-term numerical accuracy and stability, which are critical for solving multi-scale and non-linear problems. Under the well-designed integrated and modularized framework, APT serves as a universal platform for researchers from different fields, such as plasma physics, accelerator physics, space science, fusio...

  14. Tracer Equivalent Latitude: A Diagnostic Tool for Isentropic Transport Studies.

    Science.gov (United States)

    Allen, Douglas R.; Nakamura, Noboru

    2003-01-01

    Area equivalent latitude based on potential vorticity (PV) is a widely used diagnostic for isentropic transport in the stratosphere and upper troposphere. Here, an alternate method for calculating equivalent latitude is explored, namely, a numerical synthesis of a PV-like tracer from a long-term integration of the advection-diffusion equation on isentropic surfaces. It is found that the tracer equivalent latitude (TrEL) behaves much like the traditional PV equivalent latitude (PVEL) despite the simplified governing physics; this is evidenced by examining the kinematics of the Arctic lower stratospheric vortex. Yet in some cases TrEL performs markedly better as a coordinate for long-lived trace species such as ozone. These instances include analysis of lower stratospheric ozone during the Stratospheric Aerosol and Gas Experiment (SAGE) III Ozone Loss and Validation Experiment (SOLVE) campaign and three-dimensional reconstruction of total column ozone during November-December 1999 from fitted ozone-equivalent latitude relationship. It is argued that the improvement is due to the tracer being free from the diagnostic errors and certain diabatic processes that affect PV. The sensitivity of TrEL to spatial and temporal resolution, advection scheme, and driving winds is also examined.

  15. Effects of the source of energy and minerals on microbial protein synthesis in rumen using 35S as indicator. Part of a coordinated programme on tracer techniques in studies on the use of non-protein nitrogen in ruminants

    International Nuclear Information System (INIS)

    Durant, M.

    1976-05-01

    Part I. The effect of the nature of carbohydrates and minerals on microbial growth in vitro was studied in vitro to intensify rumen microbial protein synthesis from non-protein nitrogen, using phosphorus incorporation (PR). The nature of starch greatly influences urea utilization. Among the tropical tubers studied, yam Cayenesis and canna Edulis give lower urea utilization than cassava and yam Dumetorum. However, this can be improved by processing. The effects are greatest when the proportion of urea to processed cereal is ca. 4-5%. S-addition as sulfate improves urea utilization with both natural and purified diets. Part II. Results from the Jouy and Ghent laboratories were analyzed statistically, to check the accuracy of the 32 P method for estimating microbial growth, using protein-free substrates. The linear relationship between PR and every other variable was studied. Two multivariate analyses, principal components and multiple regression, were applied. Net NH 3 utilization was predicted using the equations for substrates with proteins likely to be degraded. This method appears more accurate than using the N/P ratio in microflora. Equations should only be used under the specific experiments described

  16. Preparation of the metabotropic glutamate receptor 5 (mGluR5) PET tracer [18F]FPEB for human use: An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor

    International Nuclear Information System (INIS)

    Lim, Keunpoong; Labaree, David; Li, Songye; Huang, Yiyun

    2014-01-01

    The radiotracer 3-[ 18 F]fluoro-5-(2-pyridinylethynyl)benzonitrile, or [ 18 F]FPEB, is a promising PET imaging agent for the metabotropic glutamate subtype 5 receptor (mGluR5). In an effort to develop a routine production method of this radiotracer for use in clinical research we adapted its radiosynthesis to an automated chemistry module. In the meanwhile, we also developed a simplified “one-pot” method for the preparation of the nitrobenzonitrile radiolabeling precursor for [ 18 F]FPEB and its reference standard to replace the existing multi-step synthetic approach. - Highlights: • Radiosynthesis of [ 18 F]FPEB was performed in a Tracerlab FX-FN automated module. • The radiolabeling precursor was prepared from a “one-pot” Suzuki coupling method. • Total synthesis time from EOB to a final injectable dose was about 90 min. • The procedure was applied in the routine preparation of [ 18 F]FPEB for human use

  17. Doublet Tracer Testing in Klamath Falls, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    Gudmundsson, J.S.; Johnson, S.E.; Horne, R.N.; Jackson, P. B. [Pet. Eng. Dept., Stanford University; Culver, G.G. [Geo-Heat Center, Oregon Institute of Technology, Klamath Falls, OR

    0001-01-01

    A tracer test was carried out in a geothermal doublet system to study the injection behavior of a developed reservoir known to be fractured. The doublet produces about 320 gpm of 160 degrees Fahrenheit water that is used for space heating and then injected; the wells are spaced 250 ft apart. Tracer breakthrough was observed in 2 hours and 45 minutes in the production well, indicating fracture flow. However, the tracer concentrations were low and indicated porous media flow; the tracers mixed with a reservoir volume much larger than a fracture.

  18. Doublet Tracer Testing in Klamath Falls, Oregon

    Energy Technology Data Exchange (ETDEWEB)

    Gudmundsson, J S; Johnson, S E; Horne, R N; Jackson, P B [Pet. Eng. Dept., Stanford University; Culver, G G [Geo-Heat Center, Oregon Institute of Technology, Klamath Falls, OR

    0000-12-30

    A tracer test was carried out in a geothermal doublet system to study the injection behavior of a developed reservoir known to be fractured. The doublet produces about 320 gpm of 160 degrees Fahrenheit water that is used for space heating and then injected; the wells are spaced 250 ft apart. Tracer breakthrough was observed in 2 hours and 45 minutes in the production well, indicating fracture flow. However, the tracer concentrations were low and indicated porous media flow; the tracers mixed with a reservoir volume much larger than a fracture.

  19. Tracer a application in marine outfall studies

    International Nuclear Information System (INIS)

    Genders, S.

    1979-01-01

    The applicability of radioactive and fluorescent tracers for field studies to predict or investigate waste water transport and dispersion from marine outfalls is evaluated. The application of either instantaneous or continuous tracer release, 'in situ' detection of tracers and data processing are considered. The necessity of a combined use of tracer techniques and conventional hydrographic methods for a statistical prediction of transport and dillution of waste water are pointed out. A procedure to determine an outlet distance from the coast, which satisfy bathing water criteria is outlined. (M.A.) [pt

  20. Principles and techniques of gamma ray tracers

    International Nuclear Information System (INIS)

    Claxton, K.T.

    1978-01-01

    Radioactive tracer techniques provide a very sensitive means of studying physical and chemical processes in a whole variety of different media. Some of the techniques and principles of radioactive tracers and their application to practical engineering systems are discussed. Information which has been found useful in the design of high temperature liquid sodium facilities employing radio-tracers, is presented. The report deals solely with the use of gamma-emitting species as the tracer. These find particular application for in-situ studies on engineering systems where the highly penetrating properties of gamma rays are needed for detection through strongly absorbent media such as stainless steel pepe walls. (author)

  1. Use of artificial tracers in hydrology

    International Nuclear Information System (INIS)

    1991-05-01

    The IAEA has convened an Advisory Group Meeting with the following objectives: To define the role of artificial radioactive tracers for water tracing in comparison with other non-radioactive tracers. To evaluate the real needs of artificial radioactive tracers in hydrology. To identify the fields for which artificial radioactive tracers are useful as well as those in which they can be substituted by other tracers. To discuss the strategy to be adopted to overcome the difficulties derived from the restrictions on the use of radioactive tracers in hydrology. The meeting was held at IAEA Headquarters from 19 to 22 March 1990, and was attended by 30 participants from 15 Member States. The conclusions and recommendations are that the use of artificial radioactive tracers should be restricted to cases where other tracers cannot be used or do not provide the same quality of information. Tritium, iodine-131, bromine-82, chromium-51 in the form of Cr-EDTA, technetium-99m obtained from 99 Mo-generators and gold-198 as an adsorbable tracer are, practically, the only radionuclides used for water tracing. The use of other radionuclides for this purpose does not appear to be necessary, possible and/or convenient. Refs, figs and tabs

  2. Quadratic tracer dynamical models tobacco growth

    International Nuclear Information System (INIS)

    Qiang Jiyi; Hua Cuncai; Wang Shaohua

    2011-01-01

    In order to study the non-uniformly transferring process of some tracer dosages, we assume that the absorption of some tracer by tobacco is a quadratic function of the tracer quantity of the tracer in the case of fast absorption, whereas the exclusion of the tracer from tobacco is a linear function of the tracer quantity in the case of slow exclusion, after the tracer is introduced into tobacco once at zero time. A single-compartment quadratic dynamical model of Logistic type is established for the leaves of tobacco. Then, a two-compartment quadratic dynamical model is established for leaves and calms of the tobacco. Qualitative analysis of the models shows that the tracer applied to the leaves of the tobacco is excluded finally; however, the tracer stays at the tobacco for finite time. Two methods are also given for computing the parameters in the models. Finally, the results of the models are verified by the 32 P experiment for the absorption of tobacco. (authors)

  3. Analysis of the Economic Impact of Large-Scale Deployment of Biomass Resources for Energy and Materials in the Netherlands. Macro-economics biobased synthesis report

    International Nuclear Information System (INIS)

    Hoefnagels, R.; Dornburg, V.; Faaij, A.; Banse, M.

    2009-03-01

    The Bio-based Raw Materials Platform (PGG), part of the Energy Transition in The Netherlands, commissioned the Agricultural Economics Research Institute (LEI) and the Copernicus Institute of Utrecht University to conduct research on the macro-economic impact of large scale deployment of biomass for energy and materials in the Netherlands. Two model approaches were applied based on a consistent set of scenario assumptions: a bottom-up study including technoeconomic projections of fossil and bio-based conversion technologies and a topdown study including macro-economic modelling of (global) trade of biomass and fossil resources. The results of the top-down and bottom-up modelling work are reported separately. The results of the synthesis of the modelling work are presented in this report

  4. Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors

    International Nuclear Information System (INIS)

    Christiaans, Johannes A.M.; Klein, Pieter J.; Metaxas, Athanasios; Kooijman, Esther J.M.; Schuit, Robert C.; Leysen, Josée E.; Lammertsma, Adriaan A.; Berckel, Bart N.M. van; Windhorst, Albert D.

    2014-01-01

    Introduction: The N-methyl-D-Aspartate (NMDA) receptor plays an important role in learning and memory. Overactivation is thought to play an important role in neurodegenerative disorders such as Alzheimer's disease. Currently, it is not possible to assess N-methyl-D-aspartate receptor (NMDAr) bio-availability in vivo. The purpose of this study was to develop a positron emission tomography (PET) ligand for the NR2B binding site of the NMDA receptor. Methods: N-((5-(4-fluoro-2-methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine was radiolabelled with carbon-11 in the phenyl moiety. Biodistribution and blocking studies were carried out in anaesthetized mice and in non-anaesthetized rats. Results: N-((5-(4-fluoro-2-[ 11 C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine was prepared in 49 ± 3% (decay-corrected) yield, affording 4.1 ± 0.3 GBq of formulated product at the end of synthesis with a radiochemical purity of > 99% and with a specific activity of 78 ± 10 GBq/μmol. Conclusion: A new NR2B PET ligand was developed in high yield. [ 11 C]4 readily enters the brain and binds to the NR2B subunit-containing NMDAr in the rodent brain. High sigma-1 receptor binding may, however, limit its future application as a PET probe for imaging the NR2B subunit-containing NMDAr. Anaesthesia has an effect on NMDAr function and therefore can complicate interpretation of preclinical in vivo results. In addition, effects of endogenous compounds cannot be excluded. Despite these potential limitations, further studies are warranted to investigate the values of [ 11 C]4 as an NR2B PET ligand

  5. Tracing wastewater effluents in surface and groundwaters: a couple approach with organic/inorganic tracers and isotopes

    Science.gov (United States)

    Petelet-Giraud, Emmanuelle; Baran, Nicole; Soulier, Coralie

    2017-04-01

    In the context of land use change, the origins of contamination of water resources are often multiple, including for a single chemical element or molecule. For instance, excess of nitrates in both surface and groundwater can originate from agricultural practices and wastewater effluents. The discrimination of the origins and vectors of contamination in the environment is both an environmental and societal issue in order to define an integrated water resources management at the catchment or water body scale by implementing appropriate measures to effectively struggle against pollution. The objective of this study is to define a methodology for the identification of a "domestic wastewater" contamination within surface waters and groundwater. An ideal tracer should be conservative, persistent in the different water compartments, present in quantity above the detection limit and originate from a single type of pollution source. There is, however, no ideal tracer in the strict sense. Indeed, even chloride which is present in quantity in wastewater, and which behaves conservatively in the environment, is not an univocal tracer of wastewater, as it may come from atmospheric inputs, from the dissolution of evaporitic rocks, from the salting of roads or from fertilizers. To overcome this limitation, in this study, we propose a multi-tracer approach (chemical and isotopic) to identify and validate the relevance of foreseen tracers. Among the relevant tracers of wastewater, the following may be used for their intrinsic or combined discriminant power: 1) organic effluent tracers: nitrogen contents and isotopic ratios of nitrogen and oxygen of nitrates; 2) tracer of detergents: boron contents and boron isotopes; 3) pharmaceuticals tracers: e.g. carbamazepine, ibuprofen, paracetamol, gadolinium anomaly; 4) life-style tracers: e.g. caffeine. The originality of the study relies on small capacities wastewater treatment plants without tertiary treatment process. Results on a

  6. Nanoparticle tracers in calcium carbonate porous media

    KAUST Repository

    Li, Yan Vivian; Cathles, Lawrence M.; Archer, Lynden A.

    2014-01-01

    the fractures or channels where flow occurs and thus take much less time to travel between two points. In combination with a chemical tracer they can measure the degree of flow concentration. A prerequisite for tracer applications is that the particles

  7. Tracer filamentation at an unstable ocean front

    Science.gov (United States)

    Feng, Yen Chia; Mahadevan, Amala; Thiffeault, Jean-Luc; Yecko, Philip

    2017-11-01

    A front, where two bodies of ocean water with different physical properties meet, can become unstable and lead to a flow with high strain rate and vorticity. Phytoplankton and other oceanic tracers are stirred into filaments by such flow fields, as can often be seen in satellite imagery. The stretching and folding of a tracer by a two-dimensional flow field has been well studied. In the ocean, however, the vertical shear of horizontal velocity is typically two orders of magnitude larger than the horizontal velocity gradient. Theoretical calculations show that vertical shear alters the way in which horizontal strain affects the tracer, resulting in thin, sloping structures in the tracer field. Using a non-hydrostatic ocean model of an unstable ocean front, we simulate tracer filamentation to identify the effect of vertical shear on the deformation of the tracer. In a complementary laboratory experiment, we generate a simple, vertically sheared strain flow and use dye and particle image velocimetry to quantify the filamentary structures in terms of the strain and shear. We identify how vertical shear alters the tracer filaments and infer how the evolution of tracers in the ocean will differ from the idealized two-dimensional paradigm. Support of NSF DMS-1418956 is acknowledged.

  8. Dynamic dual-tracer PET reconstruction.

    Science.gov (United States)

    Gao, Fei; Liu, Huafeng; Jian, Yiqiang; Shi, Pengcheng

    2009-01-01

    Although of important medical implications, simultaneous dual-tracer positron emission tomography reconstruction remains a challenging problem, primarily because the photon measurements from dual tracers are overlapped. In this paper, we propose a simultaneous dynamic dual-tracer reconstruction of tissue activity maps based on guidance from tracer kinetics. The dual-tracer reconstruction problem is formulated in a state-space representation, where parallel compartment models serve as continuous-time system equation describing the tracer kinetic processes of dual tracers, and the imaging data is expressed as discrete sampling of the system states in measurement equation. The image reconstruction problem has therefore become a state estimation problem in a continuous-discrete hybrid paradigm, and H infinity filtering is adopted as the estimation strategy. As H infinity filtering makes no assumptions on the system and measurement statistics, robust reconstruction results can be obtained for the dual-tracer PET imaging system where the statistical properties of measurement data and system uncertainty are not available a priori, even when there are disturbances in the kinetic parameters. Experimental results on digital phantoms, Monte Carlo simulations and physical phantoms have demonstrated the superior performance.

  9. Tracer diffusion in ternary alloys

    International Nuclear Information System (INIS)

    Tahir-Kheli, R.A.

    1985-07-01

    An intuitive extension of the theory for diffusion in dynamic binary alloys given in the preceding paper is presented. This theory has also received an independent derivation, based on more formal procedures, by Holdsworth and Elliott. We present Monte Carlo estimates for diffusion correlation factors, fsup(A), fsup(B), and fsup(C) and compare them with the theory. The agreement between the theoretical results and the Monte Carlo estimates for the correlation factors of the slow particles, i.e., fsup(C) and fsup(B), is found to be generally good. In contrast, for the correlation factor, fsup(A), referring to the diffusion coefficient of fast particles in the system, the theoretical results are found to be systematically lower by a small but resolvable margin. It is suggested that this is occasioned by the neglect of spatial constraints on the scattering of coupled tracer-background particle field pairs. (author)

  10. Raw Materials Synthesis from Heavy Metal Industry Effluents with Bioremediation and Phytomining: A Biomimetic Resource Management Approach

    Directory of Open Access Journals (Sweden)

    Salmah B. Karman

    2015-01-01

    Full Text Available Heavy metal wastewater poses a threat to human life and causes significant environmental problems. Bioremediation provides a sustainable waste management technique that uses organisms to remove heavy metals from contaminated water through a variety of different processes. Biosorption involves the use of biomass, such as plant extracts and microorganisms (bacteria, fungi, algae, yeast, and represents a low-cost and environmentally friendly method of bioremediation and resource management. Biosorption-based biosynthesis is proposed as a means of removing heavy metals from wastewaters and soils as it aids the development of heavy metal nanoparticles that may have an application within the technology industry. Phytomining provides a further green method of managing the metal content of wastewater. These approaches represent a viable means of removing toxic chemicals from the effluent produced during the process of manufacturing, and the bioremediation process, furthermore, has the potential to save metal resources from depletion. Biomimetic resource management comprises bioremediation, biosorption, biosynthesis, phytomining, and further methods that provide innovative ways of interpreting waste and pollutants as raw materials for research and industry, inspired by materials, structures, and processes in living nature.

  11. Transuranic and tracer simulant resuspension

    International Nuclear Information System (INIS)

    Sehmel, G.A.

    1977-07-01

    Plutonium resuspension results are summarized for experiments conducted at Rocky Flats, onsite on the Hanford reservation, and for winds blowing from offsite onto the Hanford reservation near the Prosser barricade boundary. In each case, plutonium resuspension was shown by increased airborne plutonium concentrations as a function of either wind speed or as compared to fallout levels. All measured airborne concentrations were below maximum permissible concentrations (MPC). Both plutonium and cesium concentrations on airborne soil were normalized by the quantity of airborne soil sampled. Airborne radionuclide concentrations in μCi/g were related to published values for radionuclide concentrations on surface soils. For this ratio of radionuclide concentration per gram on airborne soil divided by that for ground surface soil, there are eight orders of magnitude uncertainty from 10 -4 to 10 4 . Horizontal plutonium fluxes on airborne nonrespirable soils at all three sites were bracketed within the same three to four orders of magnitude from 10 -7 to 10 -3 μCi/(m 2 day) for plutonium-239 and 10 -8 to 10 -5 μCi/(m 2 day) for plutonium-238. These are the entire experimental base for nonrespirable airborne plutonium transport. Airborne respirable plutonium-239 concentrations increased with wind speed for a southeast wind direction coming from offsite near the Hanford reservation Prosser barricade. Airborne plutonium fluxes on nonrespirable particles had isotopic ratios, 240 Pu/ 239+240 Pu, similar to weapons grade plutonium rather than fallout plutonium. Resuspension rates were summarized for controlled inert particle tracer simulant experiments. Wind resuspension rates for tracers increased with wind speed to about the fifth power

  12. Studies of Tracer Dispersion and Fluid Flow in Porous Media

    Energy Technology Data Exchange (ETDEWEB)

    Rage, T.

    1996-12-31

    This doctoral thesis explores the connection between the topology of a porous medium and its macroscopic transport properties and is based on computerized simulation. In porous media, both diffusion and convection contribute to the dispersion of a tracer and their combined effect is emphasized. The governing equations are solved numerically, using finite differences and Monte Carlo technique. The influence of finite Reynolds number on the outcome of echo-experiments is discussed. Comparing experiments and simulations it is found that nonlinear inertial forces lead to a visible deformation of a returned tracer at surprisingly small Reynolds numbers. In a study of tracer dispersion and fluid flow in periodic arrays of discs it is demonstrated that the mechanisms of mechanical dispersion in periodic media and in natural (non-periodic) porous media are essentially different. Measurements of the percolation probability distribution of a sandstone sample is presented. Local porosity theory predicts that this simple geometric function of a porous medium is of dominant importance for its macroscopic transport properties. It is demonstrated that many aspects of transport through fractures can be studied by using simple but realistic models and readily available computer resources. An example may be the transport of hydrocarbon fluids from the source rock to a reservoir. 165 refs., 44 figs., 1 table

  13. Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors

    Science.gov (United States)

    Sun, Aixia; Liu, Xiang; Tang, Ganghua

    2017-12-01

    Tumor cells have an increased nutritional demand for amino acids(AAs) to satisfy their rapid proliferation. Positron-emitting nuclide labeled AAs are interesting probes and are of great importance for imaging tumors using positron emission tomography (PET). Carbon-11 and fluorine-18 labeled AAs include the [1-11C] amino acids, labeling alpha-C- amino acids, the branched-chain of amino acids and N-substituted carbon-11 labeled amino acids. These tracers target protein synthesis or amino acid(AA) transport, and their uptake mechanism mainly involves AA transport. AA PET tracers have been widely used in clinical settings to image brain tumors, neuroendocrine tumors, prostate cancer, breast cancer, non–small cell lung cancer (NSCLC) and hepatocellular carcinoma. This review focuses on the fundamental concepts and the uptake mechanism of AAs, AA PET tracers and their clinical applications.

  14. Using Tracer Technology to Characterize Contaminated Pipelines

    Energy Technology Data Exchange (ETDEWEB)

    Maresca, Joseph, W., Jr., Ph.D.; Bratton, Wesley, L., Ph.D., P.E.; Dickerson, Wilhelmina; Hales, Rochelle

    2005-12-30

    The Pipeline Characterization Using Tracers (PCUT) technique uses conservative and partitioning, reactive or other interactive tracers to remotely determine the amount of contaminant within a run of piping or ductwork. The PCUT system was motivated by a method that has been successfully used to characterize subsurface soil contaminants and is similar in operation to that of a gas chromatography column. By injecting a ?slug? of both conservative and partitioning tracers at one end (or section) of the piping and measuring the time history of the concentration of the tracers at the other end (or another section) of the pipe, the presence, location, and amount of contaminant within the pipe or duct can be determined. The tracers are transported along the pipe or duct by a gas flow field, typically air or nitrogen, which has a velocity that is slow enough so that the partitioning tracer has time to interact with the contaminant before the tracer slug completely passes over the contaminate region. PCUT not only identifies the presence of contamination, it also can locate the contamination along the pipeline and quantify the amount of residual. PCUT can be used in support of deactivation and decommissioning (D&D) of piping and ducts that may have been contaminated with hazardous chemicals such as chlorinated solvents, petroleum products, radioactive materials, or heavy metals, such as mercury.

  15. Tracers vs. trajectories in a coastal region

    Science.gov (United States)

    Engqvist, A.; Döös, K.

    2008-12-01

    Two different methods of estimating the water exchange through a Baltic coastal region have been used, consisting of particle trajectories and passive tracers. Water is traced from and to a small discharge region near the coast. The discharge material in this region is treated as zero dimensional particles or tracers with neutral buoyancy. The real discharge material could be a leakage of radio-nuclides through the sea floor from an underground repository of nuclear waste. Water exchange rates between the discharge region and the model domain are estimated using both forward and backward trajectories as well as passive tracers. The Lagrangian trajectories can account for the time evolution of the water exchange while the tracers give one average age per model grid box. Water exchange times such as residence time, age and transient times have been calculated with trajectories but only the average age (AvA) for tracers. The trajectory calculations provide a more detailed time evolution than the tracers. On the other hand the tracers are integrated "on-line" simultaneously in the sea circulation model with the same time step while the Lagrangian trajectories are integrated "off-line" from the stored model velocities with its inherent temporal resolution, presently one hour. The sub-grid turbulence is parameterised as a Laplacian diffusion for the passive tracers and with an extra stochastic velocity for trajectories. The importance of the parameterised sub-grid turbulence for the trajectories is estimated to give an extra diffusion of the same order as the Laplacian diffusion by comparing the Lagrangian dispersions with and without parameterisation. The results of the different methods are similar but depend on the chosen diffusivity coefficient with a slightly higher correlation between trajectories and tracers when integrated with a lower diffusivity coefficient.

  16. Statistically Based Morphodynamic Modeling of Tracer Slowdown

    Science.gov (United States)

    Borhani, S.; Ghasemi, A.; Hill, K. M.; Viparelli, E.

    2017-12-01

    Tracer particles are used to study bedload transport in gravel-bed rivers. One of the advantages associated with using of tracer particles is that they allow for direct measures of the entrainment rates and their size distributions. The main issue in large scale studies with tracer particles is the difference between tracer stone short term and long term behavior. This difference is due to the fact that particles undergo vertical mixing or move to less active locations such as bars or even floodplains. For these reasons the average virtual velocity of tracer particle decreases in time, i.e. the tracer slowdown. In summary, tracer slowdown can have a significant impact on the estimation of bedload transport rate or long term dispersal of contaminated sediment. The vast majority of the morphodynamic models that account for the non-uniformity of the bed material (tracer and not tracer, in this case) are based on a discrete description of the alluvial deposit. The deposit is divided in two different regions; the active layer and the substrate. The active layer is a thin layer in the topmost part of the deposit whose particles can interact with the bed material transport. The substrate is the part of the deposit below the active layer. Due to the discrete representation of the alluvial deposit, active layer models are not able to reproduce tracer slowdown. In this study we try to model the slowdown of tracer particles with the continuous Parker-Paola-Leclair morphodynamic framework. This continuous, i.e. not layer-based, framework is based on a stochastic description of the temporal variation of bed surface elevation, and of the elevation specific particle entrainment and deposition. Particle entrainment rates are computed as a function of the flow and sediment characteristics, while particle deposition is estimated with a step length formulation. Here we present one of the first implementation of the continuum framework at laboratory scale, its validation against

  17. 15N tracer kinetic studies on the validity of various 15N tracer substances for determining whole-body protein parameters in very small preterm infants

    International Nuclear Information System (INIS)

    Plath, C.; Heine, W.; Wutzke, K.D.; Krienke, L.; Toewe, J.M.; Massute, G.; Windischmann, C.

    1987-01-01

    Reliable 15 N tracer substances for tracer kinetic determination of whole-body protein parameters in very small preterm infants are still a matter of intensive research, especially after some doubts have been raised about the validity of [ 15 N]glycine, a commonly used 15 N tracer. Protein turnover, synthesis, breakdown, and further protein metabolism data were determined by a paired comparison in four preterm infants. Their post-conceptual age was 32.2 +/- 0.8 weeks, and their body weight was 1670 +/- 181 g. Tracer substances applied in this study were a [ 15 N]amino acid mixture (Ia) and [ 15 N]glycine (Ib). In a second group of three infants with a post conceptual age of 15 N-labeled 32.0 +/- 1.0 weeks and a body weight of 1,907 +/- 137 g, yeast protein hydrolysate (II) was used as a tracer substance. A three-pool model was employed for the analysis of the data. This model takes into account renal and fecal 15 N losses after a single 15 N pulse. Protein turnovers were as follows: 11.9 +/- 3.1 g kg-1 d-1 (Ia), 16.2 +/- 2.5 g kg-1 d-1 (Ib), and 10.8 +/- 3.0 g kg-1 d-1 (II). We were able to demonstrate an overestimation of the protein turnover when Ib was used. There was an expected correspondence in the results obtained from Ia and II. The 15 N-labeled yeast protein hydrolysate is a relatively cheap tracer that allows reliable determination of whole-body protein parameters in very small preterm infants

  18. The accurate particle tracer code

    Science.gov (United States)

    Wang, Yulei; Liu, Jian; Qin, Hong; Yu, Zhi; Yao, Yicun

    2017-11-01

    The Accurate Particle Tracer (APT) code is designed for systematic large-scale applications of geometric algorithms for particle dynamical simulations. Based on a large variety of advanced geometric algorithms, APT possesses long-term numerical accuracy and stability, which are critical for solving multi-scale and nonlinear problems. To provide a flexible and convenient I/O interface, the libraries of Lua and Hdf5 are used. Following a three-step procedure, users can efficiently extend the libraries of electromagnetic configurations, external non-electromagnetic forces, particle pushers, and initialization approaches by use of the extendible module. APT has been used in simulations of key physical problems, such as runaway electrons in tokamaks and energetic particles in Van Allen belt. As an important realization, the APT-SW version has been successfully distributed on the world's fastest computer, the Sunway TaihuLight supercomputer, by supporting master-slave architecture of Sunway many-core processors. Based on large-scale simulations of a runaway beam under parameters of the ITER tokamak, it is revealed that the magnetic ripple field can disperse the pitch-angle distribution significantly and improve the confinement of energetic runaway beam on the same time.

  19. Development of Radioisotope Tracer Technology

    International Nuclear Information System (INIS)

    Jung, Sung Hee; Jin, Joon Ha; Kim, Jong Bum; Kim, Jin Seop; Kim, Jae Jo; Park, Soon Chul; Lim, Don Soon; Choi, Byung Jong; Jang, Dong Soon; Kim, Hye Sook

    2007-06-01

    The project is aimed to develop the radiotracer technology for process optimization and trouble-shooting to establish the environmental and industrial application of radiation and radioisotopes. The advanced equipment and software such as high speed data acquisition system, RTD model and high pressure injection tool have developed. Based on the various field application to the refinery/petrochemical industries, the developed technology was transfer to NDT company for commercial service. For the environmental application of radiotracer technology, injector, detector sled, core sampler, RI and GPS data logging system are developed and field tests were implemented successfully at Wolsung and Haeundae beach. Additionally tracer technology were also used for the performance test of the clarifier in a wastewater treatment plant and for the leak detection in reservoirs. From the experience of case studies on radiotracer experiment in waste water treatment facilities, 'The New Excellent Technology' is granted from the ministry of environment. For future technology, preliminary research for industrial gamma transmission and emission tomography which are new technology combined with radioisotope and image reconstruction are carried out

  20. Compartmental modeling and tracer kinetics

    CERN Document Server

    Anderson, David H

    1983-01-01

    This monograph is concerned with mathematical aspects of compartmental an­ alysis. In particular, linear models are closely analyzed since they are fully justifiable as an investigative tool in tracer experiments. The objective of the monograph is to bring the reader up to date on some of the current mathematical prob­ lems of interest in compartmental analysis. This is accomplished by reviewing mathematical developments in the literature, especially over the last 10-15 years, and by presenting some new thoughts and directions for future mathematical research. These notes started as a series of lectures that I gave while visiting with the Division of Applied ~1athematics, Brown University, 1979, and have developed in­ to this collection of articles aimed at the reader with a beginning graduate level background in mathematics. The text can be used as a self-paced reading course. With this in mind, exercises have been appropriately placed throughout the notes. As an aid in reading the material, the e~d of a ...

  1. Synthesis of poly(ethylene furandicarboxylate) polyester using monomers derived from renewable resources: thermal behavior comparison with PET and PEN.

    Science.gov (United States)

    Papageorgiou, George Z; Tsanaktsis, Vasilios; Bikiaris, Dimitrios N

    2014-05-07

    Poly(ethylene-2,5-furandicarboxylate) (PEF) is a new alipharomatic polyester that can be prepared from monomers derived from renewable resources like furfural and hydroxymethylfurfural. For this reason it has gained high interest recently. In the present work it was synthesized from the dimethylester of 2,5-furandicarboxylic acid and ethylene glycol by applying the two-stage melt polycondensation method. The thermal behavior of PEF was studied in comparison to its terephthalate and naphthalate homologues poly(ethylene terephthalate) (PET) and poly(ethylene naphthalate) (PEN), which were also synthesized following the same procedure. The equilibrium melting point of PEF was found to be 265 °C while the heat of fusion for the pure crystalline PEF was estimated to be about 137 J g(-1). The crystallization kinetics was analyzed using various models. PET showed faster crystallization rates than PEN and this in turn showed faster crystallization than PEF, under both isothermal and non-isothermal conditions. The spherulitic morphology of PEF during isothermal crystallization was investigated by polarized light microscopy (PLM). A large nucleation density and a small spherulite size were observed for PEF even at low supercoolings, in contrast to PET or PEN. Thermogravimetric analysis indicated that PEF is thermally stable up to 325 °C and the temperature for the maximum degradation rate was 438 °C. These values were a little lower than those for PET or PEN.

  2. Tracer surface diffusion on UO2

    International Nuclear Information System (INIS)

    Zhou, S.Y.; Olander, D.R.

    1983-06-01

    Surface diffusion on UO 2 was measured by the spreading of U-234 tracer on the surface of a duplex diffusion couple consisting of wafers of depleted and enriched UO 2 joined by a bond of uranium metal

  3. Exploring Hydrofluorocarbons as Groundwater Age Tracers (Invited)

    Science.gov (United States)

    Haase, K. B.; Busenberg, E.; Plummer, L. N.; Casile, G.; Sanford, W. E.

    2013-12-01

    Groundwater dating tracers are an essential tool for analyzing hydrologic conditions in groundwater systems. Commonly used tracers for dating post-1940's groundwater include sulfur hexafluoride (SF6), chlorofluorocarbons (CFCs), 3H-3He, and other isotopic tracers (85Kr, δ2H and δ18O isotopes, etc.). Each tracer carries a corresponding set of advantages and limitations imposed by field, analytical, and interpretive methods. Increasing the number available tracers is appealing, particularly if they possess inert chemical properties and unique temporal emission histories from other tracers. Atmospherically derived halogenated trace gases continue to hold untapped potential for new tracers, as they are generally inert and their emission histories are well documented. SF5CF3, and CFC-13 were previously shown to have application as dating tracers, though their low mixing ratios and low solubility require large amounts of water to be degassed for their quantification. Two related groups of compounds, hydrochlorofluorocarbons (HCFCs) and hydrofluorocarbons (HFCs) are hypothesized to be potential age tracers, having similar mixing ratios to the CFCs and relatively high solubility. However, these compounds yield gas chromatography electron capture detector (GC-ECD) responses that are 10-2 -10-5 less than CFC-12, making purge and trap or field stripping GC-ECD approaches impractical. Therefore, in order to use dissolved HCFCs and HFCs as age tracers, different approaches are needed. To solve this problem, we developed an analytical method that uses an atomic emission detector (GC-AED) in place of an ECD to detect fluorinated compounds. In contrast to the ECD, the AED is a universally sensitive, highly linear, elementally specific detector. The new GC-AED system is being used to measure chlorodifluoromethane (HCFC-22), 1,1,1,2-tetrafluoroethane (HFC-134a), and other fluorinated compounds in one liter water samples to study their potential as age dating tracers. HCFC-22 is a

  4. Response of Yellowstone grizzly bears to changes in food resources: A synthesis. Final report to the Interagency Grizzly Bear Committee and Yellowstone Ecosystem Subcommittee

    Science.gov (United States)

    ,; van Manen, Frank T.; Costello, Cecily M.; Haroldson, Mark A.; Bjornlie, Daniel D.; Ebinger, Michael R.; Gunther, Kerry A.; Mahalovich, Mary Frances; Thompson, Daniel J.; Higgs, Megan D.; Irvine, Kathryn M.; Legg, Kristin; Tyers, Daniel B.; Landenburger, Lisa; Cain, Steven L.; Frey, Kevin L.; Aber, Bryan C.; Schwartz, Charles C.

    2013-01-01

    The Yellowstone grizzly bear (Ursus arctos) was listed as a threatened species in 1975 (Federal Register 40 FR:31734-31736). Since listing, recovery efforts have focused on increasing population size, improving habitat security, managing bear mortalities, and reducing bear-human conflicts. The Interagency Grizzly Bear Committee (IGBC; partnership of federal and state agencies responsible for grizzly bear recovery in the lower 48 states) and its Yellowstone Ecosystem Subcommitte (YES; federal, state, county, and tribal partners charged with recovery of grizzly bears in the Greater Yelowston Ecosystem [GYE]) tasked the Interagency Grizzly Bear Study Team to provide information and further research relevant to three concerns arising from the 9th Circuit Court of Appeals November 2011 decision: 1) the ability of grizzly bears as omnivores to find alternative foods to whitebark pine seeds; 2) literature to support their conclusions; and 3) the non-intuitive biological reality that impacts can occur to individuals without causing the overall population to decline. Specifically, the IGBC and YES requested a comprehensive synthesis of the current state of knowledge regarding whitebark pinbe decline and individual and population-level responses of grizzly bears to changing food resources in the GYE. This research was particularly relevant to grizzly bear conservation given changes in the population trajectory observed during the last decade.

  5. Determination of protein turnover parameters in athletes using 15N tracers

    International Nuclear Information System (INIS)

    Krumbiegel, P.; Kuehne, K.; Faust, H.; Bornhak, H.; Junghans, P.; Zerbes, H.

    1985-01-01

    In 2 adolescent female athletes engaged in technical-acrobatic sports the influence of a high protein diet on the protein turnover rate under training conditions was investigated by means of 15 N-glycine. Protein synthesis was significantly increased, whereas the utilization of nutritive nitrogen was decreased as expected. The 15 N tracer technique is well suited to determine the protein requirements under special training conditions

  6. Radioisotope tracers in industrial flow studies

    International Nuclear Information System (INIS)

    Easey, J.F.

    1987-01-01

    The scope of radioisotope tracer work carried out by ANSTO has involved most sectors of Australian industry including iron and steel coal, chemical, petrochemical, natural gas, metallurgical, mineral, power generation, liquified air plant, as well as port authorities, water and sewerage instrumentalities, and environmental agencies. A major class of such studies concerns itself with flow and wear studies involving industrial equipment. Some examples are discussed which illustrate the utility of radioisotope tracer techniques in these applications

  7. Tracer monitoring of enhanced oil recovery projects

    Directory of Open Access Journals (Sweden)

    Kleven R.

    2013-05-01

    Full Text Available In enhanced oil recovery (EOR, chemicals are injected into the oil reservoir, either to increase macroscopic sweep efficiency, or to reduce remaining oil saturation in swept zones. Tracers can be used to identify reservoirs that are specifically suited for EOR operations. Injection of a selection of partitioning tracers, combined with frequent sample analysis of produced fluids, provides information suited for estimation of residual oil saturation. Tracers can also be used to evaluate and optimize the application of EOR chemicals in the reservoir. Suitable tracers will follow the EOR chemicals and assist in evaluation of retention, degradation or trapping. In addition to field applications, tracers also have a large potential as a tool to perform mechanistic studies of EOR chemicals in laboratory experiments. By labelling EOR chemicals with radioactive isotopes of elements such as H, C and S, detailed studies of transport mechanisms can be carried out. Co-injection of labelled compounds in dynamic flooding experiments in porous media will give information about retention or separation of the unique compounds constituting the chemical formulation. Separation of such compounds may be detrimental to obtaining the EOR effect expected. The paper gives new information of specific methods, and discusses current status for use of tracers in EOR operations.

  8. Tracer kinetics: Modelling of tracer behaviour in nonlinear and nonsteady state systems exemplified by the evaluation of protein turnover in plant organs

    International Nuclear Information System (INIS)

    Winkler, E.

    1991-01-01

    If nonlinear biological processes are investigated by means of tracer experiments they can be modelled with linear kinetic equations (compartment equations) as long as the total system is in a stationary state. But if nonstationary behaviour is included considerations on the kinetics of the individual processes are necessary. Within the range of biological and agricultural investigations especially first order reactions (constant fraction processes), zero order reactions (constant amount process) and saturation reactions (Michaelis-Menten-kinetics) are to be taken into account. A rigorous treatment of data based on system theory can be preceeded by graphic-algebraic procedure which may be more or less uncertain in its results but which can easily be handled. An example is given of methodological considerations concerning the combination of evaluation procedures and the discrimination between different reaction mechanisms. It treats protein turnover in 2 different parts of growing wheat plants investigated by means of an 15 N-tracer experiment. Whereas in a stationary system (upper stalk section) linear tracer equations were sufficient irrespective of the true reaction mechanism, for protein synthesis in the upper leaf as a nonstationary system it was necessary to decide between the hypotheses of a zero order and a first order reaction. In accordance with statements in the literature the unambiguous result was a combination of protein synthesis as a zero order process and of protein degradation as a first order process. (orig.) [de

  9. Dolphins. LC Science Tracer Bullet.

    Science.gov (United States)

    Niskern, Diana, Comp.

    The family Delphinidae is the largest family of toothed whales. It includes not only those mammals commonly referred to as dolphins, such as the bottlenosed dolphin often seen in captivity, but also the killer whale. This literature and resources guide is not intended to be a comprehensive bibliography on dolphins; the guide is designed--as the…

  10. Proceedings of Tracer 3. International Conference on Tracers and Tracing Methods

    International Nuclear Information System (INIS)

    2004-01-01

    Tracer 3 conference is a continuation of former Tracer 1 (1998) and Tracer 2 (2001) conferences organized by CNRS - Nancy France. The objective of this 3rd conference is presentation of different aspects of tracer method applications and development of tracer methodology.The new field of activity presented at the Conference was application of stable isotopes as natural tracers for investigations of environmental processes. The conference gave the possibility for scientific information exchange between specialists from different fields of activity such as chemical engineering, chemistry, bioengineering, environmental engineering, hydrology, civil engineering, metallurgy, etc. The presentations were divided into groups covering the principal items of Conference. Section A. Fundamental development - RTD and tracer methodology, - RTD methodology and Computational Fluid Dynamics (CFD), - New tracers and detectors. Section B. Industrial applications - Environment, - Geology, hydrogeology and oil field applications, - Civil engineering, mineral engineering and metallurgy applications, - Food engineering and bioengineering, - Material engineering, - Chemical engineering. During the Conference INIS promotion materials were exposed by INIS liaison officer for Poland

  11. Proceedings of Tracer 3. International Conference on Tracers and Tracing Methods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Tracer 3 conference is a continuation of former Tracer 1 (1998) and Tracer 2 (2001) conferences organized by CNRS - Nancy France. The objective of this 3rd conference is presentation of different aspects of tracer method applications and development of tracer methodology.The new field of activity presented at the Conference was application of stable isotopes as natural tracers for investigations of environmental processes. The conference gave the possibility for scientific information exchange between specialists from different fields of activity such as chemical engineering, chemistry, bioengineering, environmental engineering, hydrology, civil engineering, metallurgy, etc. The presentations were divided into groups covering the principal items of Conference. Section A. Fundamental development - RTD and tracer methodology, - RTD methodology and Computational Fluid Dynamics (CFD), - New tracers and detectors. Section B. Industrial applications - Environment, - Geology, hydrogeology and oil field applications, - Civil engineering, mineral engineering and metallurgy applications, - Food engineering and bioengineering, - Material engineering, - Chemical engineering. During the Conference INIS promotion materials were exposed by INIS liaison officer for Poland.

  12. Long residence times - bad tracer tests?

    Science.gov (United States)

    Ghergut, Julia; Behrens, Horst; Sauter, Martin

    2015-04-01

    Tracer tests conducted at geothermal well doublets or triplets in the Upper Rhine Rift Valley [1] all face, with very few exceptions so far, one common issue: lack of conclusive tracer test results, or tracer signals still undetectable for longer than one or two years after tracer injection. While the reasons for this surely differ from site to site (Riehen, Landau, Insheim, Bruchsal, ...), its effects on how the usefulness of tracer tests is perceived by the non-tracer community are pretty much the same. The 'poor-signal' frustration keeps nourishing two major 'alternative' endeavours : (I) design and execute tracer tests in single-well injection-withdrawal (push-pull), 'instead of' inter-well flow-path tracing configurations; (II) use 'novel' tracer substances instead of the 'old' ones which have 'obviously failed'. Frustration experienced with most inter-well tracer tests in the Upper Rhine Rift Valley has also made them be regarded as 'maybe useful for EGS' ('enhanced', or 'engineered' geothermal systems, whose fluid RTD typically include a major share of values below one year), but 'no longer worthwhile a follow-up sampling' in natural, large-scale hydrothermal reservoirs. We illustrate some of these arguments with the ongoing Bruchsal case [2]. The inter-well tracer test conducted at Bruchsal was (and still is!) aimed at assessing inter-well connectivity, fluid residence times, and characterizing the reservoir structure [3]. Fluid samples taken at the geothermal production well after reaching a fluid turnover of about 700,000 m3 showed tracer concentrations in the range of 10-8 Minj per m3, in the liquid phase of each sample (Minj being the total quantity of tracer injected as a short pulse at the geothermal re-injection well). Tracer signals might actually be higher, owing to tracer amounts co-precipitated and/or adsorbed onto the solid phase whose accumulation in the samples was unavoidable (due to pressure relief and degassing during the very sampling

  13. TRACER - TRACING AND CONTROL OF ENGINEERING REQUIREMENTS

    Science.gov (United States)

    Turner, P. R.

    1994-01-01

    TRACER (Tracing and Control of Engineering Requirements) is a database/word processing system created to document and maintain the order of both requirements and descriptive material associated with an engineering project. A set of hierarchical documents are normally generated for a project whereby the requirements of the higher level documents levy requirements on the same level or lower level documents. Traditionally, the requirements are handled almost entirely by manual paper methods. The problem with a typical paper system, however, is that requirements written and changed continuously in different areas lead to misunderstandings and noncompliance. The purpose of TRACER is to automate the capture, tracing, reviewing, and managing of requirements for an engineering project. The engineering project still requires communications, negotiations, interactions, and iterations among people and organizations, but TRACER promotes succinct and precise identification and treatment of real requirements separate from the descriptive prose in a document. TRACER permits the documentation of an engineering project's requirements and progress in a logical, controllable, traceable manner. TRACER's attributes include the presentation of current requirements and status from any linked computer terminal and the ability to differentiate headers and descriptive material from the requirements. Related requirements can be linked and traced. The program also enables portions of documents to be printed, individual approval and release of requirements, and the tracing of requirements down into the equipment specification. Requirement "links" can be made "pending" and invisible to others until the pending link is made "binding". Individuals affected by linked requirements can be notified of significant changes with acknowledgement of the changes required. An unlimited number of documents can be created for a project and an ASCII import feature permits existing documents to be incorporated

  14. Tracers of air-sea gas exchange

    International Nuclear Information System (INIS)

    Liss, P.S.

    1988-01-01

    The flux of gas across the air-sea interface is determined by the product of the interfacial concentration difference driving the exchange and a rate constant, often termed the transfer velocity. The concentration-difference term is generally obtained by direct measurement, whereas more indirect approaches are required to estimate the transfer velocity and its variation as a function of controlling parameters such as wind and sea state. Radioactive tracers have proved particularly useful in the estimation of air-sea transfer velocities and, recently, stable purposeful tracers have also started to be used. In this paper the use of the following tracers to determine transfer velocities at the sea surface is discussed: natural and bomb-produced 14 C, dissolved oxygen, 222 Rn and sulphur hexafluoride. Other topics covered include the relation between transfer velocity and wind speed as deduced from tracer and wind-tunnel studies, and the discrepancy between transfer velocities determined by using tracers and from eddy correlation measurements in the atmosphere. (author)

  15. Fracture Characterization in Reactive Fluid-Fractured Rock Systems Using Tracer Transport Data

    Science.gov (United States)

    Mukhopadhyay, S.

    2014-12-01

    Fractures, whether natural or engineered, exert significant controls over resource exploitation from contemporary energy sources including enhanced geothermal systems and unconventional oil and gas reserves. Consequently, fracture characterization, i.e., estimating the permeability, connectivity, and spacing of the fractures is of critical importance for determining the viability of any energy recovery program. While some progress has recently been made towards estimating these critical fracture parameters, significant uncertainties still remain. A review of tracer technology, which has a long history in fracture characterization, reveals that uncertainties exist in the estimated parameters not only because of paucity of scale-specific data but also because of knowledge gaps in the interpretation methods, particularly in interpretation of tracer data in reactive fluid-rock systems. We have recently demonstrated that the transient tracer evolution signatures in reactive fluid-rock systems are significantly different from those in non-reactive systems (Mukhopadhyay et al., 2013, 2014). For example, the tracer breakthrough curves in reactive fluid-fractured rock systems are expected to exhibit a long pseudo-state condition, during which tracer concentration does not change by any appreciable amount with passage of time. Such a pseudo-steady state condition is not observed in a non-reactive system. In this paper, we show that the presence of this pseudo-steady state condition in tracer breakthrough patterns in reactive fluid-rock systems can have important connotations for fracture characterization. We show that the time of onset of the pseudo-steady state condition and the value of tracer concentration in the pseudo-state condition can be used to reliably estimate fracture spacing and fracture-matrix interface areas.

  16. Coefficients of tracer transfer through membranes. Pt. 7

    Energy Technology Data Exchange (ETDEWEB)

    Dorabialska, A; Hawlicka, E; Plonka, A [Politechnika Lodzka (Poland)

    1974-01-01

    The doubled value of the tracer transfer coefficient in the self-diffusion process is equal to the sum of tracer transfer coefficients in the diffusion and interfusion processes. The fundamental phenomenological relation can be deduced for the coefficients of tracer transfer between two phases of electrolyte solutions spearated by a virtual boundary. Indeed, the doubled value of the tracer mobility in the self-diffusion experiment (no concentration gradient of the traced substance) is equal to the sum of the tracer mobilities in the diffusion (tracer movement along with the concentration gradient of the traced substance) and interfusion experiments (tracer movement against the concentration gradient of the traced substance). Thus the doubled value of the tracer transfer coefficient in the self-diffusion process should be equal to the sum of tracer transfer coefficients in the diffusion and interfusion processes. The experimental verification of that fundamental relation is presented.

  17. Simulation and interpretation of inter-well tracer tests

    Directory of Open Access Journals (Sweden)

    Dugstad Øyvind

    2013-05-01

    Full Text Available In inter-well tracer tests (IWTT, chemical compounds or radioactive isotopes are used to label injection water and gas to establish well connections and fluid patterns in petroleum reservoirs. Tracer simulation is an invaluable tool to ease the interpretation of IWTT results and is also required for assisted history matching application of tracer data. In this paper we present a new simulation technique to analyse and interpret tracer results. Laboratory results are used to establish and test formulations of the tracer conservation equations, and the technique is used to provide simulated tracer responses that are compared with observed tracer data from an extensive tracer program. The implemented tracer simulation methodology use a fast post-processing of previously simulated reservoir simulation runs. This provides a fast, flexible and powerful method for analysing gas tracer behaviour in reservoirs. We show that simulation time for tracers can be reduced by factor 100 compared to solving the tracer flow equations simultaneously with the reservoir fluid flow equations. The post-processing technique, combined with a flexible built-in local tracer-grid refinement is exploited to reduce numerical smearing, particularly severe for narrow tracer pulses.

  18. Enhanced Oil Recovery: Aqueous Flow Tracer Measurement

    Energy Technology Data Exchange (ETDEWEB)

    Joseph Rovani; John Schabron

    2009-02-01

    A low detection limit analytical method was developed to measure a suite of benzoic acid and fluorinated benzoic acid compounds intended for use as tracers for enhanced oil recovery operations. Although the new high performance liquid chromatography separation successfully measured the tracers in an aqueous matrix at low part per billion levels, the low detection limits could not be achieved in oil field water due to interference problems with the hydrocarbon-saturated water using the system's UV detector. Commercial instrument vendors were contacted in an effort to determine if mass spectrometry could be used as an alternate detection technique. The results of their work demonstrate that low part per billion analysis of the tracer compounds in oil field water could be achieved using ultra performance liquid chromatography mass spectrometry.

  19. Biological tracer for waste site characterization

    International Nuclear Information System (INIS)

    Strong-Gunderson, J.

    1995-01-01

    Remediating hazardous waste sites requires detailed site characterization. In groundwater remediation, characterizing the flow paths and velocity is a major objective. Various tracers have been used for measuring groundwater velocity and transport of contaminants, colloidal particles, and bacteria and nutrients. The conventional techniques use dissolved solutes, dyes. and gases to estimate subsurface transport pathways. These tracers can provide information on transport and diffusion into the matrix, but their estimates for groundwater flow through fractured regions are very conservative. Also, they do not have the same transport characteristics as bacteria and suspended colloid tracers, both of which must be characterized for effective in-place remediation. Bioremediation requires understanding bacterial transport and nutrient distribution throughout the acquifer, knowledge of contaminants s mobile colloidal particles is just essential

  20. Use of radioactive tracers in dynamic sedimentology

    International Nuclear Information System (INIS)

    Tola, Francois.

    1982-01-01

    In the first part, developments in the use of radioactive tracers in sedimentology are recalled together with the corresponding fields of application and the identities of the main users. The state-of-the-art in France is also discussed; The main characteristics of the method are then described and compared with those of more classical methods. The results that can be obtained with tracer methods are then outlined. The criteria employed to establish the granulometry characteristics of the tracer, the particular radioisotope to be used, and the masses and activities involved, are treated. A list is then given of the main isotopes available in France and their characteristics. The various different labelling techniques employed are studied together with their respective advantages and disadvantages. The special case of pelitic sediments is mentioned. The use of reduced model isotope generators, double labelling and applications to studies of the mud plug in the Gironde Estuary are also discussed. The methods and materials used for injecting and detecting tracers are described, emphasis being given to the economic factors associated with the use of radioactive tracers in sedimentology. The second part of the report contains two chapters: - studies of transport by driftage: presentation and analysis of results and the application of the Count Rate Balance method to obtain quantitative information on transport; - studies of in-suspension transport of fine sediments in the sea: the procedures adopted from the moment when the tracer is introduced up to the time when the results are analyzed and interpreted, enables the trajectories and mean velocities of the transported sediments to be determined together with their degree of dilution and their settling speeds and rates; it is also possible to investigate the evolution and horizontal dispersion of the sediments in this way. Results from recent experiments are presented in both parts of the report

  1. Geologic flow characterization using tracer techniques

    International Nuclear Information System (INIS)

    Klett, R.D.; Tyner, C.E.; Hertel, E.S. Jr.

    1981-04-01

    A new tracer flow-test system has been developed for in situ characterization of geologic formations. This report describes two sets of test equipment: one portable and one for testing in deep formations. Equations are derived for in situ detector calibration, raw data reduction, and flow logging. Data analysis techniques are presented for computing porosity and permeability in unconfined isotropic media, and porosity, permeability and fracture characteristics in media with confined or unconfined two-dimensional flow. The effects of tracer pulse spreading due to divergence, dispersion, and porous formations are also included

  2. SIMULASI JARINGAN KOMPUTER MENGGUNAKAN CISCO PACKET TRACER

    Directory of Open Access Journals (Sweden)

    M Mufadhol

    2012-01-01

    Full Text Available Perkembangan jaringan komputer saat ini begitu pesat, monitoring jaringan komputer akan menjadi suatu hal yang sulit dan rumit. Koneksi jaringan komputer merupakan suatu hal yang mendasar dalam suatu jaringan, karena bila koneksi itu bermasalah maka semua jenis aplikasi yang dijalankan melalui jaringan komputer tidak dapat digunakan. Cisco packet tracer dapat digunakan untuk simulasi yang mencerminkan arsitektur dan juga model dari jaringan komputer pada sistem jaringan yang digunakan. Dengan menggunakan aplikasi cisco packet tracer, simulasi mengenai jaringan dapat dimanfaatkan menjadi informasi tentang keadaan koneksi komputer dalam suatu jaringan.

  3. Selection of tracers for oil and gas evaluation

    International Nuclear Information System (INIS)

    Bjoernstad, T.

    1991-08-01

    The importance of tracer tests in reservoir descriptions is increasingly acknowledged by reservoir engineers as a method to obtain valuable dynamic information from the reservoir. The report describes the ''state-of-the art'' on tracer technology for interwell investigations. Experiences gained from a number of reported field tracer tests are reviewed, and results from detailed laboratory investigations on the static and dynamic behavior of various tracer molecules are discussed. A critical evaluation of the applicability of the various identified tracers is provided. Present and future trends in the development of tracer technology for reservoir description are sketched. 64 refs., 12 figs., 2 tabs

  4. Supplier Resource Mobilization

    DEFF Research Database (Denmark)

    Ellegaard, Chris; Kragh, Hanne; Andersen, Poul Houman

    theoretical perspectives. This review, synthesis, and resultant discussion allow us to propose that future research should look closer at the resource activation process on the supplier side, the role of the buyer-supplier relationship in resource mobilization, and the approach of the buying company...

  5. Groundwater circulations within a tropical humid andesitic volcanic watershed using the temperature as a tracer

    Science.gov (United States)

    Selles, Adrien; Violette, Sophie; Hendrayana, Heru

    2014-05-01

    Groundwater flow within volcano-detritic environment, is of prime importance to many human needs and activities, from the supply of clean drinking water to the extraction of hydrocarbons or geothermal energy. However, the heterogeneity of the geological formations makes difficult to quantify the groundwater spatial distribution. Moreover, its temporal variation in tropical humid regions is sometimes poorly known. For instance, the surronding of the Merapi volcano, in Central Java, Indonesia, is an area of high but seasonal rainfall, and extensive crop irrigation. It has a large population and a need to increase food and potable water supplies depending upon exploiting groundwater ressources. The stress on these resources increases with the intensification of the demography, the agricultural practices and the industrial exploitations. In order to implement a sustainable management of the water resources, the description of the groundwater circulations and the quantification of the resources is needed. A mutidisciplinary approach has been performed at the watershed scale, including geology, hydrogeochemistry and long term hydrogeological monitoring. The data synthesis and constisency have been confirm with a numerical model of physical processes. Based on a geological and geomorphological study, the hydrogeological watershed on the Eastern flank of the Merapi volcano is composed by an alternation of aquitards (mainly ashes, tuffs and clay) and aquifers (sand, gravel and boulders). The deep aquifers are agenced in conduit following the burried channel of the paleo-rivers. The eastern flank of Merapi provides excellent example of a volcanic-sedimentary environment. From 20 cold springs of 3 spring zones, sampled on 2 hydrological years (2011 to 2013), the study of the transfer into the saturated zone from upstream to downstream, given the geological context and topography, allows to estimate the role of supply from high and low altitudes to the recharge processes. The

  6. Tracer gas diffusion sampling test plan

    International Nuclear Information System (INIS)

    Rohay, V.J.

    1993-01-01

    Efforts are under way to employ active and passive vapor extraction to remove carbon tetrachloride from the soil in the 200 West Area an the Hanford Site as part of the 200 West Area Carbon Tetrachloride Expedited Response Action. In the active approach, a vacuum is applied to a well, which causes soil gas surrounding the well to be drawn up to the surface. The contaminated air is cleaned by passage through a granular activated carbon bed. There are questions concerning the radius of influence associated with application of the vacuum system and related uncertainties about the soil-gas diffusion rates with and without the vacuum system present. To address these questions, a series of tracer gas diffusion sampling tests is proposed in which an inert, nontoxic tracer gas, sulfur hexafluoride (SF 6 ), will be injected into a well, and the rates of SF 6 diffusion through the surrounding soil horizon will be measured by sampling in nearby wells. Tracer gas tests will be conducted at sites very near the active vacuum extraction system and also at sites beyond the radius of influence of the active vacuum system. In the passive vapor extraction approach, barometric pressure fluctuations cause soil gas to be drawn to the surface through the well. At the passive sites, the effects of barometric ''pumping'' due to changes in atmospheric pressure will be investigated. Application of tracer gas testing to both the active and passive vapor extraction methods is described in the wellfield enhancement work plan (Rohay and Cameron 1993)

  7. Use of labeled compounds in tracer experiments

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The use of radiotracers in research has become common. This chapter looks at some of the underlying assumptions and advantages of labeled compounds: advantages of radiotracers; availability of suitable tracers and labeled compounds; purity of labeled compounds; autoradiolysis; storage of labeled compounds; detection systems for chromatography and electrophoretic methods. 14 refs., 2 figs

  8. Rate tracer studies of heterogeneous catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Happel, J; Kiang, S

    1977-10-01

    An analysis is presented of the extent to which parameters involved in transient tracing of isotopic species in heterogeneous catalysis can be determined by experiments in which tracer concentrations are measured as a function of time. Different treatments for open and closed systems with the over-all reaction at equilibrium or irreversible were developed.

  9. Tracer dispersion in planar multipole flows

    International Nuclear Information System (INIS)

    Koplik, J.; Redner, S.; Hinch, E.J.

    1994-01-01

    We study the motion of passive Brownian tracer particles in steady two-dimensional potential flows between sources and sinks. Our primary focus is understanding the long-time properties of the transit time probability distribution for the tracer to reach the sink p(t) and the influence of the flow geometry on this probability. A variety of illustrative case studies is considered. For radial potential flow in an annular region, competition between convection and diffusion leads to nonuniversal decay of the transit time probability. Dipolar and higher multipole flows are found to exhibit generic features, such as a power-law decay in p(t) with an exponent determined by the multipole moment, an exponential cutoff related to stagnation points, and a ''shoulder'' in p(t) that is related to reflection from the system boundaries. For spatially extended sinks, it is also shown that the spatial distribution of the collected tracer is independent of the overall magnitude of the flow field and that p(t) decays as a power law with a geometry-dependent exponent. Our results may offer the possibility of using tracer measurements to characterize the flow geometry of porous media

  10. Nanoparticle tracers in calcium carbonate porous media

    KAUST Repository

    Li, Yan Vivian

    2014-07-15

    Tracers are perhaps the most direct way of diagnosing subsurface fluid flow pathways for ground water decontamination and for natural gas and oil production. Nanoparticle tracers could be particularly effective because they do not diffuse away from the fractures or channels where flow occurs and thus take much less time to travel between two points. In combination with a chemical tracer they can measure the degree of flow concentration. A prerequisite for tracer applications is that the particles are not retained in the porous media as the result of aggregation or sticking to mineral surfaces. By screening eight nanoparticles (3-100 nm in diameter) for retention when passed through calcium carbonate packed laboratory columns in artificial oil field brine solutions of variable ionic strength we show that the nanoparticles with the least retention are 3 nm in diameter, nearly uncharged, and decorated with highly hydrophilic polymeric ligands. The details of these column experiments and the tri-modal distribution of zeta potential of the calcite sand particles in the brine used in our tests suggests that parts of the calcite surface have positive zeta potential and the retention of negatively charged nanoparticles occurs at these sites. Only neutral nanoparticles are immune to at least some retention. © 2014 Springer Science+Business Media.

  11. Using neural networks to describe tracer correlations

    Directory of Open Access Journals (Sweden)

    D. J. Lary

    2004-01-01

    Full Text Available Neural networks are ideally suited to describe the spatial and temporal dependence of tracer-tracer correlations. The neural network performs well even in regions where the correlations are less compact and normally a family of correlation curves would be required. For example, the CH4-N2O correlation can be well described using a neural network trained with the latitude, pressure, time of year, and methane volume mixing ratio (v.m.r.. In this study a neural network using Quickprop learning and one hidden layer with eight nodes was able to reproduce the CH4-N2O correlation with a correlation coefficient between simulated and training values of 0.9995. Such an accurate representation of tracer-tracer correlations allows more use to be made of long-term datasets to constrain chemical models. Such as the dataset from the Halogen Occultation Experiment (HALOE which has continuously observed CH4  (but not N2O from 1991 till the present. The neural network Fortran code used is available for download.

  12. Using radioactive tracer technique in municipal hygiene

    International Nuclear Information System (INIS)

    Yurasova, O.I.

    1974-01-01

    Work of the A. N. Syrsin Institute of General and Municiapl Hygiene using raidoactive tracers is reviewed. The studies include research on protein metabolism in the living organism following action of unfavorable factors of the environment; determination of the paths of introduction into the organism of substances with an alien composition; and study of the rate of resorption of subcutaneous papuli. Results are shown of radioactive-tracer studies on the mechanism of action of poisonous substances on the living organism and of migration of alien chemical compounds in the organism and in objects in the environment. It is concluded that the radioactive tracer method has wide application in municipal hygiene and sanitary microbiology. The absence of laborious operations, economy of time, precision of the experiments, and the possibility of obtaining additional information on the mechanism of action of poisonous substances on the organism and the low cost of such studies compared with other methods makes the radioactive tracer method economically attractive. The studies made show the various types of use of the method in municipal hygiene and sanitary microbiology

  13. Hybrid tracers for sentinel node biopsy

    International Nuclear Information System (INIS)

    Van Den Berg, N. S.; Kleinjan, G. I.; Valdés-Olmos, R. A.; Buckle, T.; Van Leeuwen, F. I.; Klop, W. M.; Horenblas, S.; Van Der Poel, H. G.

    2014-01-01

    Conventional sentinel node (SN) mapping is performed by injection of a radiocolloid followed by lymphoscintigraphy to identify the number and location of the primary tumor draining lymph node(s), the so-called SN(s). Over the last decade research has focused on the introduction of new imaging agents that can further aid (surgical) SN identification. Different tracers for SN mapping, with varying sizes and isotopes have been reported, most of which have proven their value in a clinical setting. A major challenge lies in transferring this diagnostic information obtained at the nuclear medicine department to the operating theatre thereby providing the surgeon with (image) guidance. Conventionally, an intraoperative injection of vital blue dye or a fluorescence dye is given to allow intraoperative optical SN identification. However, for some indications, the radiotracer-based approach remains crucial. More recently, hybrid tracers, that contain both a radioactive and fluorescent label, were introduced to allow for direct integration of pre- and intraoperative guidance technologies. Their potential is especially high when they are used in combination with new surgical imaging modalities and navigation tools. Next to a description of the known tracers for SN mapping, this review discusses the application of hybrid tracers during SN biopsy and how the introduction of these new techniques can further aid in translation of nuclear medicine information into the operating theatre.

  14. Fractal tracer distributions in turbulent field theories

    DEFF Research Database (Denmark)

    Hansen, J. Lundbek; Bohr, Tomas

    1998-01-01

    We study the motion of passive tracers in a two-dimensional turbulent velocity field generated by the Kuramoto-Sivashinsky equation. By varying the direction of the velocity-vector with respect to the field-gradient we can continuously vary the two Lyapunov exponents for the particle motion and t...

  15. Suitability of tracers; Eignung von Tracern

    Energy Technology Data Exchange (ETDEWEB)

    Klotz, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany). Inst. fuer Hydrologie

    1999-02-01

    Hydrological tracer techniques are a means of making statements on the direction and speed of underground water. One of the simpler tasks is to find out whether there is hydrological communication between two given points. This requires a determination of the direction of flow, which places less exacting demands on the properties of the tracer than does the task of determining the flow velocity of underground water. Tracer methods can serve to infer from flow velocity the distance (flow) velocity, which is defined as the ratio between the distance between two points located in flow direction and the actual time it takes water to flow from one to the other. [Deutsch] Mit Hilfe der hydrologischen Markierungstechniken koennen Aussagen ueber die Richtung und die Geschwindigkeit von Bewegungen des unterirdischen Wassers gemacht werden. Der einfachere Fall liegt vor, wenn festgestellt werden soll, ob zwischen zwei Punkten eine hydrologische Verbindung besteht. Bei dieser Fliessrichtungsbestimmung sind die Forderungen an die Eigenschaften der einzusetzenden Tracer geringer als bei der Bestimmung der Geschwindigkeit des unterirdischen Wassers. Von den Geschwindigkeiten des unterirdischen Wassers ist die Abstands-(Fliess)geschwindigkeit, die definiert ist durch das Verhaeltnis aus dem Abstand und der wahren Fliesszeit zwischen zwei in Bewegungsrichtung gelegenen Punkten, durch Tracermethoden zu bestimmen. (orig.)

  16. Using radioactive tracer technique in municipal hygiene

    Energy Technology Data Exchange (ETDEWEB)

    Yurasova, O I [Institut Obshchej i Kommunal' noj Gigieny, Moscow (USSR)

    1974-01-01

    Work of the A. N. Syrsin Institute of General and Municiapl Hygiene using raidoactive tracers is reviewed. The studies include research on protein metabolism in the living organism following action of unfavorable factors of the environment; determination of the paths of introduction into the organism of substances with an alien composition; and study of the rate of resorption of subcutaneous papuli. Results are shown of radioactive-tracer studies on the mechanism of action of poisonous substances on the living organism and of migration of alien chemical compounds in the organism and in objects in the environment. It is concluded that the radioactive tracer method has wide application in municipal hygiene and sanitary microbiology. The absence of laborious operations, economy of time, precision of the experiments, and the possibility of obtaining additional information on the mechanism of action of poisonous substances on the organism and the low cost of such studies compared with other methods makes the radioactive tracer method economically attractive. The studies made show the various types of use of the method in municipal hygiene and sanitary microbiology.

  17. Pipeline leak detection using volatile tracers

    International Nuclear Information System (INIS)

    Thompson, G.M.; Golding, R.D.

    1993-01-01

    A method of leak detection for underground storage tanks and pipelines adds volatile tracers to the products in the tanks and analyzes the surrounding shallow soil gases for tracer vapors. This method has several advantages: the success of the test is not limited by the size and structural design of the vessels, tanks can be tested at any fill level without taking the tank out of service, the location of a leak along a pipeline is clearly marked by the location of the tracer, and liquid leaks as small as 0.2 liters per hour (lph) can be detected. A limitation is: the backfill material must have some degree of air permeability in the zone above the water table. Several field tests document the success achieved using this method. A tracer leak detection system was installed at Homestead AFB after several other testing methods failed to locate a leak at a valve pit location along approximately 4 kilometers of fuel transfer piping. The leak was detected to the side of the valve pit at a depth of approximately 2.5 meters below the ground surface. Another installation of Edwards AFB involved the collection of 415 soil gas samples along approximately 3,050 meters of 15.25-centimeter fiberglass pipeline. Fourteen separate leaks were detected

  18. Methods for conduct of atmospheric tracer studies at ANSTO

    Energy Technology Data Exchange (ETDEWEB)

    Clark, G H; Stone, D J.M.; Pascoe, J H [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia). Environment Division

    2000-07-01

    A perfluorocarbon atmospheric tracer system has been developed to investigate atmospheric dispersion processes in the region surrounding the Lucas Heights Science and Technology Centre. This report discusses the tracer release, sampling and analysis methods.

  19. Laplace transform in tracer kinetic modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hauser, Eliete B., E-mail: eliete@pucrs.br [Instituto do Cerebro (InsCer/FAMAT/PUC-RS), Porto Alegre, RS, (Brazil). Faculdade de Matematica

    2013-07-01

    The main objective this paper is to quantify the pharmacokinetic processes: absorption, distribution and elimination of radiopharmaceutical(tracer), using Laplace transform method. When the drug is administered intravenously absorption is complete and is available in the bloodstream to be distributed throughout the whole body in all tissues and fluids, and to be eliminated. Mathematical modeling seeks to describe the processes of distribution and elimination through compartments, where distinct pools of tracer (spatial location or chemical state) are assigned to different compartments. A compartment model is described by a system of differential equations, where each equation represents the sum of all the transfer rates to and from a specific compartment. In this work a two-tissue irreversible compartment model is used for description of tracer, [{sup 18}F]2-fluor-2deoxy-D-glucose. In order to determine the parameters of the model, it is necessary to have information about the tracer delivery in the form of an input function representing the time-course of tracer concentration in arterial blood or plasma. We estimate the arterial input function in two stages and apply the Levenberg-Marquardt Method to solve nonlinear regressions. The transport of FDG across de arterial blood is very fast in the first ten minutes and then decreases slowly. We use de Heaviside function to represent this situation and this is the main contribution of this study. We apply the Laplace transform and the analytical solution for two-tissue irreversible compartment model is obtained. The only approach is to determinate de arterial input function. (author)

  20. Guidebook on radioisotope tracers in industry

    International Nuclear Information System (INIS)

    1990-01-01

    The idea of using tracers (chemical, dyes, etc.) in the investigation of complex physical phenomena has always attracted the attention of scientists and engineers. When radioactive isotopes became available it was immediately recognized that they offered an almost ideal solution to tracer selection. This book is devoted to reviewing the present status of the tracer method as such and to its applications to those branches of industry which have derived large benefits from the use of this modern technology. The main objectives of the IAEA's Industrial Applications and Chemistry Section is to help Member States in introducing to their own industries the different isotope and radiation techniques which have become available as a result of developments in the nuclear sciences. This section proposed the preparation of this guidebook, putting together various radiotracer methods and the experience obtained so far in their industrial use. Chapters 2 to 4 cover the general concept of tracers, technology and safety aspects, as well as data evaluation and interpretation. In chapter 5, therefore, general applications are discussed. In chapter 6, specialists in selected fields discuss their experience in radiotracer applications in various types of industrial activity. Most case studies are illustrated by at least one detailed example of an experiment carried out at an industrial installation. Current trends in the development of radiotracer methods are discussed in chapter 7, from both a theoretical and a practical viewpoint. Some possible new RTT applications in the future are also discussed here. Sealed radioactive sources are used almost as often as radioisotope tracers in industrial measurements. Annex I gives a short review of these techniques. Readers who are interested in the basic principles of radioisotope production will find the necessary information in Annex II. Annexes III, V and VI provide a demonstration of fundamental relations and properties; useful

  1. Stable isotope usage in developing countries: Safe tracer tools to measure human nutritional status

    International Nuclear Information System (INIS)

    Klein, P.D.; Klein, E.R.

    1987-01-01

    How many calories are used when a nursing mother feeds her infant? How much milk does an infant receive in one week? What is the impact of the environment on the energy needs of children? How adequately does dietary protein sustain the synthesis of body constituents? What types of foods best nourish a child recovering from intestinal diseases such as diarrhoea? Quantitative answers to questions such as these can be obtained from the use of stable, non-radioactive isotopic tracers. Answers to these questions are important in assessing the nutritional status of infants, children, pregnant women and nursing mothers, as well as that of individuals who subsist on marginal food supplies. Because stable isotopic tracers are completely safe and without hazard, they can be used freely in health, nutrition, and agriculture studies in all populations

  2. New radioactive tracers can help find cause of jaundice

    International Nuclear Information System (INIS)

    Carrard, G.

    1987-01-01

    Radioactive tracers for the investigation of a condition known as persistent jaundice of the newborn, have been designed, prepared and tested at ANSTO. The tracers are chemical compounds of the radioactive elements gallium-67 and indium-111. They given lower radiation doses than the conventional radioactive tracer, iodine-131, used in these studies

  3. PET tracers for somatostatin receptor imaging of neuroendocrine tumors

    DEFF Research Database (Denmark)

    Johnbeck, Camilla Bardram; Knigge, Ulrich; Kjær, Andreas

    2014-01-01

    Neuroendocrine tumors have shown rising incidence mainly due to higher clinical awareness and better diagnostic tools over the last 30 years. Functional imaging of neuroendocrine tumors with PET tracers is an evolving field that is continuously refining the affinity of new tracers in the search...... these PET tracers further....

  4. Industrial tracer application in people's republic of china

    International Nuclear Information System (INIS)

    Sun Maoyi

    1987-01-01

    A number of important applications of radioisotopes and their compounds used as tracers in petroleum industry, metallurgical industry, mechanical industry, chemical industry, electronic industry, hydrology and water conservancy in China are introduced in this paper. And the tracer technique applied to entomology is also mentioned. The industrial tracer applications are successful and beneficial in People's Republic of China from the examples given. (author)

  5. Natural tracer profiles across argillaceous formations

    International Nuclear Information System (INIS)

    Mazurek, Martin; Alt-Epping, Peter; Bath, Adrian; Gimmi, Thomas; Niklaus Waber, H.; Buschaert, Stephane; Canniere, Pierre De; Craen, Mieke De; Gautschi, Andreas; Savoye, Sebastien; Vinsot, Agnes; Wemaere, Isabelle; Wouters, Laurent

    2011-01-01

    Highlights: → Solute transport processes in clay and shale formations at nine sites are examined. → Conservative pore-water tracers (e.g. Cl - , δ 18 O, δ 2 H, He) show regular profiles. → These indicate the dominance of diffusive transport over times of 10 5 -10 6 years. → The contribution of vertical advection to transport is limited or negligible. → Modelled evolution times are in line with independent palaeo-hydrogeological data. - Abstract: Argillaceous formations generally act as aquitards because of their low hydraulic conductivities. This property, together with the large retention capacity of clays for cationic contaminants, has brought argillaceous formations into focus as potential host rocks for the geological disposal of radioactive and other waste. In several countries, programmes are under way to characterise the detailed transport properties of such formations at depth. In this context, the interpretation of profiles of natural tracers in pore waters across the formations can give valuable information about the large-scale and long-term transport behaviour of these formations. Here, tracer-profile data, obtained by various methods of pore-water extraction for nine sites in central Europe, are compiled. Data at each site comprise some or all of the conservative tracers: anions (Cl - , Br - ), water isotopes (δ 18 O, δ 2 H) and noble gases (mainly He). Based on a careful evaluation of the palaeo-hydrogeological evolution at each site, model scenarios are derived for initial and boundary pore-water compositions and an attempt is made to numerically reproduce the observed tracer distributions in a consistent way for all tracers and sites, using transport parameters derived from laboratory or in situ tests. The comprehensive results from this project have been reported in . Here the results for three sites are presented in detail, but the conclusions are based on model interpretations of the entire data set. In essentially all cases, the

  6. Prospect of radon as a tracer in studying of landslide forecast

    International Nuclear Information System (INIS)

    Zhang Huifeng; Ding Dexin

    2004-01-01

    Radon, as a chemical element of radioactivity, is widely used in the fields of earth-quake monitoring, prospecting mine and exploring resource. This paper discussed the theory of radon's separating out from the soil and the theory and means of surveying radon. It also relates the radon anomaly in the measuring process of soil radon, caused by the interferring of the environmental factors in measurement results. It further clarifies the wilde application of radon as a tracer in landslide forecast. (authors)

  7. 15N tracer techniques in pediatric research

    International Nuclear Information System (INIS)

    Heine, W.; Richter, I.; Plath, C.; Wutzke, K.; Stolpe, H.J.; Tiess, M.; Toewe, J.

    1983-01-01

    The main topics of the review comprise mathematical fundamentals of the determination of N metabolism parameters using the 3-pool method, the value of different 15 N tracer substances for the determination of whole-body protein parameters, the utilization of parenterally applied D-amino acids, studies on the influence of different diets on the N metabolism of premature infants with the 15 N tracer technique, the application of the 15 N-glycine-STH-test for the evaluation of the therapeutic effect of STH in children suffering from hypothalamico-hypophyseal dwarfism, in vivo studies on urea utilization by the infant intestinal flora under various dietary regimens as well as in vitro investigations on the utilization of 15 N-labelled urea and NH 4 Cl, resp., by the intestinal flora

  8. Radioactive tracers and the cracking modelings

    International Nuclear Information System (INIS)

    Bettens, B.

    1982-01-01

    The use of tracers (3H and 14 C) labelled in specific positions is an intensive contribution to the understanding and the revealing of the very often complex cracking modeling. The pyrolytic decay of the phenol and the cresols, of the aniline, of the phenantrene and its hydrogenated derived products were investigated and are presented as examples. The decay mechanisms give a theoretical knowledge of the thermal cracking and allow to handle the results on an industrial scale. (AF)

  9. The medical applications of radioactive tracers

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, J.G.

    1947-12-31

    This report provides a broad yet in depth overview of the use of radioactive materials as tracers in medicine and biology for the period of 1935--1947. Particular attention is paid to is of radio-sodium, radio-iodine, radio-iron, radio-phosphorus, radio-strontium, and fission products. The main thrust of this paper is human rather than animal work and focuses in work that has been published.

  10. Tracer technology modeling the flow of fluids

    CERN Document Server

    Levenspiel, Octave

    2012-01-01

    A vessel’s behavior as a heat exchanger, absorber, reactor, or other process unit is dependent upon how fluid flows through the vessel.  In early engineering, the designer would assume either plug flow or mixed flow of the fluid through the vessel.  However, these assumptions were oftentimes inaccurate, sometimes being off by a volume factor of 100 or more.  The result of this unreliable figure produced ineffective products in multiple reaction systems.   Written by a pioneering researcher in the field of chemical engineering, the tracer method was introduced to provide more accurate flow data.  First, the tracer method measured the actual flow of fluid through a vessel.  Second, it developed a suitable model to represent the flow in question.  Such models are used to follow the flow of fluid in chemical reactors and other process units, like in rivers and streams, or solid and porous structures.  In medicine, the tracer method is used to study the flow of chemicals—harmful  and harmless—in the...

  11. Radon diagnostics and tracer gas measurements

    International Nuclear Information System (INIS)

    Jilek, K.; Brabec, M.

    2004-01-01

    An outline is presented of the tracer gas technique, which is used for continuous measurements of air ventilation rate (generally time-varying) and for simultaneous estimation of air ventilation rate and radon entry rate, and some of its limitations are discussed. The performance of this technique in the calculation of the air ventilation rate is demonstrated on real data from routine measurements. The potential for air ventilation rate estimation based on radon measurements only is discussed. A practical application is described of the tracer gas technique to a simultaneous estimation of the air ventilation rate and radon entry rate in a real house where the effectiveness of radon remedy was tested. The following main advantages of the CO tracer gas techniques are stressed: (i) The averaging method continuous determination of the ventilation rate with good accuracy (≤ 20 %). (ii) The newly presented and verified method based on simultaneous measurements of radon concentration and CO gas concentration enables separate continuous measurements of the radon entry rate and ventilation rate. The results of comparative measurements performed with the aim to estimate the inaccuracy in determination of radon entry rate showed acceptable and good agreement up to approximately 10 %. The results of comparative measurements performed with the aim to estimate the mutual commensuration of the method to the determination of the ventilation rate confirmed the expected unreliability the two parametric non-linear regression method, which is the most frequently used method in radon diagnostic in the Czech Republic

  12. The ATLAS DDM Tracer monitoring framework

    International Nuclear Information System (INIS)

    Zang Dongsong; Garonne, Vincent; Barisits, Martin; Lassnig, Mario; Andrew Stewart, Graeme; Molfetas, Angelos; Beermann, Thomas

    2012-01-01

    The DDM Tracer monitoring framework is aimed to trace and monitor the ATLAS file operations on the Worldwide LHC Computing Grid. The volume of traces has increased significantly since the framework was put in production in 2009. Now there are about 5 million trace messages every day and peaks can be near 250Hz, with peak rates continuing to climb, which gives the current structure a big challenge. Analysis of large datasets based on on-demand queries to the relational database management system (RDBMS), i.e. Oracle, can be problematic, and have a significant effect on the database's performance. Consequently, We have investigated some new high availability technologies like messaging infrastructure, specifically ActiveMQ, and key-value stores. The advantages of key value store technology are that they are distributed and have high scalability; also their write performances are usually much better than RDBMS, all of which are very useful for the Tracer monitoring framework. Indexes and distributed counters have been also tested to improve query performance and provided almost real time results. In this paper, the design principles, architecture and main characteristics of Tracer monitoring framework will be described and examples of its usage will be presented.

  13. Commercial applications of perfluorocarbon tracer (PFT) technology

    International Nuclear Information System (INIS)

    Dietz, R.N.

    1991-06-01

    Tracer technology can be successfully applied to many leak-checking and monitoring evaluations of operating systems (e.g., building HVACs), manufacturing processes and products (e.g., air conditioners), and subsurface components and systems (e.g., underground storage tanks). Perfluorocarbon tracer (PFT) technology is the most sensitive of all tracer technologies because the ambient background levels of the five (5) routinely-used PFTs are in the range of parts per 10 15 parts of air (i.e., parts per quadrillion-ppq) and this technology's instrumentation can measure down to those levels. The effectiveness of this technology is achieved both in terms of cost (very little PFT need to be used) and detectability; for example, very small leaks can be rapidly detected. The PFT compounds, which are environmentally and biologically safe to use, are commercially available as are the sampling and analysis instrumentation. This presentation concerns (1) the steps being taken to commercialize this technology, (2) new applications of processes currently under study, and (3) applications in areas of use that will be particularly beneficial to the environment. 21 refs., 2 figs., 2 tabs

  14. You are not always what we think you eat: selective assimilation across multiple whole-stream isotopic tracer studies

    Science.gov (United States)

    W. K. Dodds; S. M. Collins; S. K. Hamilton; J. L. Tank; S. Johnson; J. R. Webster; K. S. Simon; M. R. Whiles; H. M. Rantala; W. H. McDowell; S. D. Peterson; T. Riis; C. L. Crenshaw; S. A. Thomas; P. B. Kristensen; B. M. Cheever; A. S. Flecker; N. A. Griffiths; T. Crowl; E. J. Rosi-Marshall; R. El-Sabaawi; E. Martí

    2014-01-01

    Analyses of 21 15N stable isotope tracer experiments, designed to examine food web dynamics in streams around the world, indicated that the isotopic composition of food resources assimilated by primary consumers (mostly invertebrates) poorly reflected the presumed food sources. Modeling indicated that consumers assimilated only 33–50% of the N...

  15. Numerical flow models and their calibration using tracer based ages: Chapter 10

    Science.gov (United States)

    Sanford, W.

    2013-01-01

    Any estimate of ‘age’ of a groundwater sample based on environmental tracers requires some form of geochemical model to interpret the tracer chemistry (chapter 3) and is, therefore, referred to in this chapter as a tracer model age. the tracer model age of a groundwater sample can be useful for obtaining information on the residence time and replenishment rate of an aquifer system, but that type of data is most useful when it can be incorporated with all other information that is known about the groundwater system under study. groundwater fl ow models are constructed of aquifer systems because they are usually the best way of incorporating all of the known information about the system in the context of a mathematical framework that constrains the model to follow the known laws of physics and chemistry as they apply to groundwater flow and transport. It is important that the purpose or objective of the study be identified first before choosing the type and complexity of the model to be constructed, and to make sure such a model is necessary. The purpose of a modelling study is most often to characterize the system within a numerical framework, such that the hydrological responses of the system can be tested under potential stresses that might be imposed given future development scenarios. As this manual discusses dating as it applies to old groundwater, most readers are likely to be interested in studying regional groundwater flow systems and their water resource potential.

  16. A new approach to tracer transport analysis: From fracture systems to strongly heterogeneous porous media

    International Nuclear Information System (INIS)

    Tsang, Chin-Fu.

    1989-02-01

    Many current development and utilization of groundwater resources include a study of their flow and transport properties. These properties are needed in evaluating possible changes in groundwater quality and potential transport of hazardous solutes through the groundwater system. Investigation of transport properties of fractured rocks is an active area of research. Most of the current approaches to the study of flow and transport in fractured rocks cannot be easily used for analysis of tracer transport field data. A new approach is proposed based on a detailed study of transport through a fracture of variable aperture. This is a two-dimensional strongly heterogeneous permeable system. It is suggested that tracer breakthrough curves can be analyzed based on an aperture or permeability probability distribution function that characterizes the tracer flow through the fracture. The results are extended to a multi-fracture system and can be equally applied to a strongly heterogeneous porous medium. Finally, the need for multi-point or line and areal tracer injection and observation tests is indicated as a way to avoid the sensitive dependence of point measurements on local permeability variability. 30 refs., 15 figs

  17. Current radiosynthesis strategies for 5-HT2A receptor PET tracers

    DEFF Research Database (Denmark)

    Herth, Matthias M; Knudsen, Gitte M

    2015-01-01

    Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been...... made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning...

  18. Emission quantification using the tracer gas dispersion method: The influence of instrument, tracer gas species and source simulation

    DEFF Research Database (Denmark)

    Delre, Antonio; Mønster, Jacob; Samuelsson, Jerker

    2018-01-01

    The tracer gas dispersion method (TDM) is a remote sensing method used for quantifying fugitive emissions by relying on the controlled release of a tracer gas at the source, combined with concentration measurements of the tracer and target gas plumes. The TDM was tested at a wastewater treatment...... plant for plant-integrated methane emission quantification, using four analytical instruments simultaneously and four different tracer gases. Measurements performed using a combination of an analytical instrument and a tracer gas, with a high ratio between the tracer gas release rate and instrument...... precision (a high release-precision ratio), resulted in well-defined plumes with a high signal-to-noise ratio and a high methane-to-tracer gas correlation factor. Measured methane emission rates differed by up to 18% from the mean value when measurements were performed using seven different instrument...

  19. Asian Tracer Experiment and Atmospheric Modeling (TEAM) Project: Draft Field Work Plan for the Asian Long-Range Tracer Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Allwine, K Jerry; Flaherty, Julia E.

    2007-08-01

    This report provides an experimental plan for a proposed Asian long-range tracer study as part of the international Tracer Experiment and Atmospheric Modeling (TEAM) Project. The TEAM partners are China, Japan, South Korea and the United States. Optimal times of year to conduct the study, meteorological measurements needed, proposed tracer release locations, proposed tracer sampling locations and the proposed durations of tracer releases and subsequent sampling are given. Also given are the activities necessary to prepare for the study and the schedule for completing the preparation activities leading to conducting the actual field operations. This report is intended to provide the TEAM members with the information necessary for planning and conducting the Asian long-range tracer study. The experimental plan is proposed, at this time, to describe the efforts necessary to conduct the Asian long-range tracer study, and the plan will undoubtedly be revised and refined as the planning goes forward over the next year.

  20. Chemical and Isotopic Tracers of Groundwater Sustainability: an Overview of New Science Directions

    Science.gov (United States)

    Bullen, T.

    2002-12-01

    Groundwater sustainability is an emerging concept that is rapidly gaining attention from both scientists and water resource managers, particularly with regard to contamination and degradation of water quality in strategic aquifers. The sustainability of a groundwater resource is a complex function of its susceptibility to factors such as intrusion of poor-quality water from diverse sources, lack of sufficient recharge and reorganization of groundwater flowpaths in response to excessive abstraction. In theory the critical limit occurs when degradation becomes irreversible, such that remediative efforts may be fruitless on a reasonable human time scale. Chemical and isotopic tracers are proving to be especially useful tools for assessment of groundwater sustainability issues such as characterization of recharge, identification of potential sources, pathways and impacts of contaminants and prediction of how hydrology will change in response to excessive abstraction. A variety of relatively cost-efficient tracers are now available with which to assess the susceptibility of groundwater reserves to contamination from both natural and anthropogenic sources, and may provide valuable monitoring and regulatory tools for water resource managers. In this overview, the results of several ongoing groundwater studies by the U.S. Geological Survey will be discussed from the perspective of implications for new science directions for groundwater sustainability research that can benefit water policy development. A fundamental concept is that chemical and isotopic tracers used individually often provide ambiguous information, and are most effective when used in a rigorous "multi-tracer" context that considers the complex linkages between the hydrology, geology and biology of groundwater systems.

  1. CityFlux perfluorocarbon tracer experiments

    Directory of Open Access Journals (Sweden)

    F. K. Petersson

    2010-07-01

    Full Text Available In June 2006, two perfluorocarbon tracer experiments were conducted in central Manchester UK as part of the CityFlux campaign. The main aim was to investigate vertical dispersion in an urban area during convective conditions, but dispersion mechanisms within the street network were also studied. Paired receptors were used in most cases where one receptor was located at ground level and one at roof level. One receptor was located on the roof of Portland Tower which is an 80 m high building in central Manchester. Source receptor distances in the two experiments varied between 120 and 600 m.

    The results reveal that maximum concentration was sometimes found at roof level rather than at ground level implying the effectiveness of convective forces on dispersion. The degree of vertical dispersion was found to be dependent on source receptor distance as well as on building height in proximity to the release site.

    Evidence of flow channelling in a street canyon was also found. Both a Gaussian profile and a street network model were applied and the results show that the urban topography may lead to highly effective flow channelling which therefore may be a very important dispersion mechanism should the right meteorological conditions prevail.

    The experimental results from this campaign have also been compared with a simple urban dispersion model that was developed during the DAPPLE framework and show good agreement with this.

    The results presented here are some of the first published regarding vertical dispersion. More tracer experiments are needed in order to further characterise vertical concentration profiles and their dependence on, for instance, atmospheric stability. The impact of urban topography on pollutant dispersion is important to focus on in future tracer experiments in order to improve performance of models as well as for our understanding of the relationship between air quality and public health.

  2. CityFlux perfluorocarbon tracer experiments

    Science.gov (United States)

    Petersson, F. K.; Martin, D.; White, I. R.; Henshaw, S. J.; Nickless, G.; Longley, I.; Percival, C. J.; Gallagher, M.; Shallcross, D. E.

    2010-07-01

    In June 2006, two perfluorocarbon tracer experiments were conducted in central Manchester UK as part of the CityFlux campaign. The main aim was to investigate vertical dispersion in an urban area during convective conditions, but dispersion mechanisms within the street network were also studied. Paired receptors were used in most cases where one receptor was located at ground level and one at roof level. One receptor was located on the roof of Portland Tower which is an 80 m high building in central Manchester. Source receptor distances in the two experiments varied between 120 and 600 m. The results reveal that maximum concentration was sometimes found at roof level rather than at ground level implying the effectiveness of convective forces on dispersion. The degree of vertical dispersion was found to be dependent on source receptor distance as well as on building height in proximity to the release site. Evidence of flow channelling in a street canyon was also found. Both a Gaussian profile and a street network model were applied and the results show that the urban topography may lead to highly effective flow channelling which therefore may be a very important dispersion mechanism should the right meteorological conditions prevail. The experimental results from this campaign have also been compared with a simple urban dispersion model that was developed during the DAPPLE framework and show good agreement with this. The results presented here are some of the first published regarding vertical dispersion. More tracer experiments are needed in order to further characterise vertical concentration profiles and their dependence on, for instance, atmospheric stability. The impact of urban topography on pollutant dispersion is important to focus on in future tracer experiments in order to improve performance of models as well as for our understanding of the relationship between air quality and public health.

  3. PIV tracer behavior on propagating shock fronts

    International Nuclear Information System (INIS)

    Glazyrin, Fyodor N; Mursenkova, Irina V; Znamenskaya, Irina A

    2016-01-01

    The present work was aimed at the quantitative particle image velocimetry (PIV) measurement of a velocity field near the front of a propagating shock wave and the study of the dynamics of liquid tracers crossing the shock front. For this goal, a shock tube with a rectangular cross-section (48  ×  24 mm) was used. The flat shock wave with Mach numbers M  =  1.4–2.0 propagating inside the tube channel was studied as well as an expanding shock wave propagating outside the channel with M  =  1.2–1.8 at its main axis. The PIV imaging of the shock fronts was carried out with an aerosol of dioctyl sebacate (DEHS) as tracer particles. The pressures of the gas in front of the shock waves studied ranged from 0.013 Mpa to 0.1 MPa in the series of experiments. The processed PIV data, compared to the 1D normal shock theory, yielded consistent values of wake velocity immediately behind the plain shock wave. Special attention was paid to the blurring of the velocity jump on the shock front due to the inertial particle lag and peculiarities of the PIV technique. A numerical algorithm was developed for analysis and correction of the PIV data on the shock fronts, based on equations of particle-flow interaction. By application of this algorithm, the effective particle diameter of the DEHS aerosol tracers was estimated as 1.03  ±  0.12 μm. A number of different formulations for particle drag were tested with this algorithm, with varying success. The results show consistency with previously reported experimental data obtained for cases of stationary shock waves. (paper)

  4. Survey on industrial applications of radioactive tracers

    International Nuclear Information System (INIS)

    Kim, Jae Rok; Yoo, Young Soo; Lee, Jong Doo; Awh, Ok Doo; Kim, Jun Hyung

    1986-12-01

    Current status and future feasibilities of industrial tracer applications in the Republic of Korea have been surveyed. Microleak detection using Krypton-85 in eight electronics industrial companies, and efficiency tests of steam generators in four nuclear power plants using Sodium-24 are the principal applications in Korea. Future applications are expected for mercury inventory in one soda industrial company, and alkali movement studies in two cement industrial companies. Korean industries expressed deep interest in leak detection in underground pipelines, abrasion/corrosion studies, mixing rate and residence time measurements. (Author)

  5. Pharmaceuticals as Groundwater Tracers - Applications and Limitations

    Science.gov (United States)

    Scheytt, T. J.; Mersmann, P.; Heberer, T.

    2003-12-01

    Pharmaceutically active substances and metabolites are found at concentrations up to the microgram/L-level in groundwater samples from the Berlin (Germany) area and from several other places world wide. Among the compounds detected in groundwater are clofibric acid, propyphenazone, diclofenac, ibuprofen, and carbamazepine. Clofibric acid, the active metabolite of clofibrate and etofibrate (blood lipid regulators) is detected in groundwater at maximum concentrations of 7300 ng/L. Among the most important input paths of drugs are excretion and disposal into the sewage system. Groundwater contamination is likely to be due to leaky sewage systems, influent streams, bank filtration, and irrigation with effluent water from sewage treatment plants. There are no known natural sources of the above mentioned pharmaceuticals. The use of pharmaceuticals as tracers may include: (a) Quantification of infiltration from underground septic tanks (b) Detection of leaky sewage systems / leaky sewage pipes (c) Estimation of the effectiveness of sewage treatment plants (d) Identification of transport pathways of other organic compounds (e) Quantification of surface water / groundwater interaction (f) Characterization of the biodegradation potential. The use of pharmaceuticals as tracers is limited by variations in input. These variations depend on the amount of drugs prescribed and used in the study area, the social structure of the community, the amount of hospital discharge, and temporal concentration variations. Furthermore, the analysis of trace amounts of pharmaceuticals is sophisticated and expensive and may therefore limit the applicability of pharmaceuticals as tracers. Finally, the transport and degradation behavior of pharmaceuticals is not fully understood. Preliminary experiments in the laboratory were conducted using sediment material and groundwater from the Berlin area to evaluate the transport and sorption behavior of selected drugs. Results of the column experiments

  6. Tracer preparate and method for its production

    International Nuclear Information System (INIS)

    Pratt, F.P.; Gagnon, D.

    1978-01-01

    The injectable tracer preparate for investigations to determine the blood flow in organs or the effect of drugs on the blood flow consists of a core of ion exchanger resin coated with polyfuran or a polymer which is the reaction product of a monomer catalysable by acid or base. The nuclei have a diameter of 10 to 200 micron, the coating thickness is between 1 and 3 micron. Ions of Ce 141, Cr 51, Sr 85, Sr 46 or Co 57 of strength 0.1-100 millicurie are adsorbed on the nucleus. (DG) [de

  7. Tracer techniques in estimating nuclear materials holdup

    International Nuclear Information System (INIS)

    Pillay, K.K.S.

    1987-01-01

    Residual inventory of nuclear materials remaining in processing facilities (holdup) is recognized as an insidious problem for safety of plant operations and safeguarding of special nuclear materials (SNM). This paper reports on an experimental study where a well-known method of radioanalytical chemistry, namely tracer technique, was successfully used to improve nondestructive measurements of holdup of nuclear materials in a variety of plant equipment. Such controlled measurements can improve the sensitivity of measurements of residual inventories of nuclear materials in process equipment by several orders of magnitude and the good quality data obtained lend themselves to developing mathematical models of holdup of SNM during stable plant operations

  8. Measurements of waste tank passive ventilation rates using tracer gases

    International Nuclear Information System (INIS)

    Huckaby, J.L.; Olsen, K.B.; Sklarew, D.S.; Evans, J.C.; Remund, K.M.

    1997-09-01

    This report presents the results of ventilation rate studies of eight passively ventilated high-level radioactive waste tanks using tracer gases. Head space ventilation rates were determined for Tanks A-101, AX-102, AX-103, BY-105, C-107, S-102, U-103, and U-105 using sulfur hexafluoride (SF 6 ) and/or helium (He) as tracer gases. Passive ventilation rates are needed for the resolution of several key safety issues. These safety issues are associated with the rates of flammable gas production and ventilation, the rates at which organic salt-nitrate salt mixtures dry out, and the estimation of organic solvent waste surface areas. This tracer gas study involves injecting a tracer gas into the tank headspace and measuring its concentration at different times to establish the rate at which the tracer is removed by ventilation. Tracer gas injection and sample collection were performed by SGN Eurisys Service Corporation and/or Lockheed Martin Hanford Corporation, Characterization Project Operations. Headspace samples were analyzed for He and SF 6 by Pacific Northwest National Laboratory (PNNL). The tracer gas method was first demonstrated on Tank S-102. Tests were conducted on Tank S-102 to verify that the tracer gas was uniformly distributed throughout the tank headspace before baseline samples were collected, and that mixing was sufficiently vigorous to maintain an approximately uniform distribution of tracer gas in the headspace during the course of the study. Headspace samples, collected from a location about 4 in away from the injection point and 15, 30, and 60 minutes after the injection of He and SF 6 , indicated that both tracer gases were rapidly mixed. The samples were found to have the same concentration of tracer gases after 1 hour as after 24 hours, suggesting that mixing of the tracer gas was essentially complete within 1 hour

  9. Chemotherapeutic agent and tracer composition and use thereof

    International Nuclear Information System (INIS)

    Babb, A. L.

    1985-01-01

    A therapeutic composition suitable for extracorporeal treatment of whole blood comprises a dialyzable chemotherapeutic agent and a dialyzable fluorescable tracer means. The removal rate of the fluorescable tracer compound from treated blood during hemodialysis is a function of the removal rate of unreacted chemotherapeutic agent present. The residual chemotherapeutic agent concentration after hemodialysis is ascertained by measuring the concentration of the fluorescable tracer compound in a dialysate using fluorometric techniques

  10. Atmospheric Gas Tracers in Groundwater: Theory, Sampling. Measurement and Interpretation

    International Nuclear Information System (INIS)

    Bayari, C.S.

    2002-01-01

    Some of the atmospheric gasses posses features that are sought in an environmental tracer of hydrogeologic interest. Among these, chlorofluorocarbons, sulfur hegzafluoride, carbon tetrachloride, methyl chloroform, krypton-85 etc. have found increasing use in groundwater age dating studies during the last ten years. This paper explains the theory of their use as tracer and discusses the major concerns as related to their sampling and analyses. Factors affecting their applicability and the approach to interpret tracer gas data is briefly outlined

  11. Compilation and analyses of results from cross-hole tracer tests with conservative tracers

    Energy Technology Data Exchange (ETDEWEB)

    Hjerne, Calle; Nordqvist, Rune; Harrstroem, Johan (Geosigma AB (Sweden))

    2010-09-15

    Radionuclide transport in hydrogeological formations is one of the key factors for the safety analysis of a future repository of nuclear waste. Tracer tests have therefore been an important field method within the SKB investigation programmes at several sites since the late 1970's. This report presents a compilation and analyses of results from cross-hole tracer tests with conservative tracers performed within various SKB investigations. The objectives of the study are to facilitate, improve and reduce uncertainties in predictive tracer modelling and to provide supporting information for SKB's safety assessment of a final repository of nuclear waste. More specifically, the focus of the report is the relationship between the tracer mean residence time and fracture hydraulic parameters, i.e. the relationship between mass balance aperture and fracture transmissivity, hydraulic diffusivity and apparent storativity. For 74 different combinations of pumping and injection section at six different test sites (Studsvik, Stripa, Finnsjoen, Aespoe, Forsmark, Laxemar), estimates of mass balance aperture from cross-hole tracer tests as well as transmissivity were extracted from reports or in the SKB database Sicada. For 28 of these combinations of pumping and injection section, estimates of hydraulic diffusivity and apparent storativity from hydraulic interference tests were also found. An empirical relationship between mass balance aperture and transmissivity was estimated, although some uncertainties for individual data exist. The empirical relationship between mass balance aperture and transmissivity presented in this study deviates considerably from other previously suggested relationships, such as the cubic law and transport aperture as suggested by /Dershowitz and Klise 2002/, /Dershowitz et al. 2002/ and /Dershowitz et al. 2003/, which also is discussed in this report. No clear and direct empirical relationship between mass balance aperture and hydraulic

  12. Tracer Testing for Estimating Heat Transfer Area in Fractured Reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Pruess, Karsten; van Heel, Ton; Shan, Chao

    2004-05-12

    A key parameter governing the performance and life-time of a Hot Fractured Rock (HFR) reservoir is the effective heat transfer area between the fracture network and the matrix rock. We report on numerical modeling studies into the feasibility of using tracer tests for estimating heat transfer area. More specifically, we discuss simulation results of a new HFR characterization method which uses surface-sorbing tracers for which the adsorbed tracer mass is proportional to the fracture surface area per unit volume. Sorption in the rock matrix is treated with the conventional formulation in which tracer adsorption is volume-based. A slug of solute tracer migrating along a fracture is subject to diffusion across the fracture walls into the adjacent rock matrix. Such diffusion removes some of the tracer from the fluid in the fractures, reducing and retarding the peak in the breakthrough curve (BTC) of the tracer. After the slug has passed the concentration gradient reverses, causing back-diffusion from the rock matrix into the fracture, and giving rise to a long tail in the BTC of the solute. These effects become stronger for larger fracture-matrix interface area, potentially providing a means for estimating this area. Previous field tests and modeling studies have demonstrated characteristic tailing in BTCs for volatile tracers in vapor-dominated reservoirs. Simulated BTCs for solute tracers in single-phase liquid systems show much weaker tails, as would be expected because diffusivities are much smaller in the aqueous than in the gas phase, by a factor of order 1000. A much stronger signal of fracture-matrix interaction can be obtained when sorbing tracers are used. We have performed simulation studies of surface-sorbing tracers by implementing a model in which the adsorbed tracer mass is assumed proportional to the fracture-matrix surface area per unit volume. The results show that sorbing tracers generate stronger tails in BTCs, corresponding to an effective

  13. 18F-labelled annexin V: a PET tracer for apoptosis imaging

    International Nuclear Information System (INIS)

    Murakami, Yoshihiro; Tatsumi, Mitsuyoshi; Ichise, Rikiya; Nishimura, Shintaro; Takamatsu, Hiroyuki; Noda, Akihiro; Taki, Junichi; Tait, Jonathan F.

    2004-01-01

    Annexin V can be used to detect apoptotic cells in vitro and in vivo, based on its ability to identify extracellular phosphatidylserine, which arises during apoptosis. In the present study, we examined the synthesis of fluorine-18 labelled annexin V as a positron emission tomography tracer for apoptosis imaging. The distribution of [ 18 F]annexin V and technetium-99m labelled annexin V, a well-characterised SPET tracer for apoptosis imaging, was compared. [ 18 F]annexin V was synthesised using N-succinimidyl 4-[ 18 F]fluorobenzoate as an 18 F labelling reagent. Synthesised and purified [ 18 F]annexin V was confirmed by SDS-PAGE. In an ex vivo imaging experiment, [ 18 F]annexin V was intravenously injected into rats 24 h after the induction of myocardial ischaemia, and accumulation in the left ventricle was examined. [ 18 F]annexin V accumulated in the infarct area of the left ventricle, where apoptotic cells were observed. In separate experiments, [ 18 F]annexin V or [ 99m Tc]annexin V was intravenously injected into ischaemic or normal animals, and the distribution of the tracers was compared. In ischaemic animals, accumulation of [ 18 F]annexin V and [ 99m Tc]annexin V in the infarct area was about threefold higher than in the non-infarct area. Furthermore, the ratio of accumulation in the normal heart to the blood radioactivity was not significantly different between the tracers. In normal animals, however, the uptake of [ 18 F]annexin V in the liver, spleen and kidney was much lower than that of [ 99m Tc]annexin V. The low uptake of [ 18 F]annexin V in these organs might represent an advantage over [ 99m Tc]annexin V. (orig.)

  14. Performance Testing of Tracer Gas and Tracer Aerosol Detectors for use in Radionuclide NESHAP Compliance Testing

    Energy Technology Data Exchange (ETDEWEB)

    Fuehne, David Patrick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lattin, Rebecca Renee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-06-28

    The Rad-NESHAP program, part of the Air Quality Compliance team of LANL’s Compliance Programs group (EPC-CP), and the Radiation Instrumentation & Calibration team, part of the Radiation Protection Services group (RP-SVS), frequently partner on issues relating to characterizing air flow streams. This memo documents the most recent example of this partnership, involving performance testing of sulfur hexafluoride detectors for use in stack gas mixing tests. Additionally, members of the Rad-NESHAP program performed a functional trending test on a pair of optical particle counters, comparing results from a non-calibrated instrument to a calibrated instrument. Prior to commissioning a new stack sampling system, the ANSI Standard for stack sampling requires that the stack sample location must meet several criteria, including uniformity of tracer gas and aerosol mixing in the air stream. For these mix tests, tracer media (sulfur hexafluoride gas or liquid oil aerosol particles) are injected into the stack air stream and the resulting air concentrations are measured across the plane of the stack at the proposed sampling location. The coefficient of variation of these media concentrations must be under 20% when evaluated over the central 2/3 area of the stack or duct. The instruments which measure these air concentrations must be tested prior to the stack tests in order to ensure their linear response to varying air concentrations of either tracer gas or tracer aerosol. The instruments used in tracer gas and aerosol mix testing cannot be calibrated by the LANL Standards and Calibration Laboratory, so they would normally be sent off-site for factory calibration by the vendor. Operational requirements can prevent formal factory calibration of some instruments after they have been used in hazardous settings, e.g., within a radiological facility with potential airborne contamination. The performance tests described in this document are intended to demonstrate the reliable

  15. The ATLAS DDM Tracer monitoring framework

    CERN Document Server

    ZANG, D; The ATLAS collaboration; BARISITS, M; LASSNIG, M; Andrew STEWART, G; MOLFETAS, A; BEERMANN, T

    2012-01-01

    The DDM Tracer Service is aimed to trace and monitor the atlas file operations on the Worldwide LHC Computing Grid. The volume of traces has increased significantly since the service started in 2009. Now there are about ~5 million trace messages every day and peaks of greater than 250Hz, with peak rates continuing to climb, which gives the current service structure a big challenge. Analysis of large datasets based on on-demand queries to the relational database management system (RDBMS), i.e. Oracle, can be problematic, and have a significant effect on the database's performance. Consequently, We have investigated some new high availability technologies like messaging infrastructure, specifically ActiveMQ, and key-value stores. The advantages of key value store technology are that they are distributed and have high scalability; also their write performances are usually much better than RDBMS, all of which are very useful for the Tracer service. Indexes and distributed counters have been also tested to improve...

  16. Advection and dispersion of bed load tracers

    Science.gov (United States)

    Lajeunesse, Eric; Devauchelle, Olivier; James, François

    2018-05-01

    We use the erosion-deposition model introduced by Charru et al. (2004) to numerically simulate the evolution of a plume of bed load tracers entrained by a steady flow. In this model, the propagation of the plume results from the stochastic exchange of particles between the bed and the bed load layer. We find a transition between two asymptotic regimes. The tracers, initially at rest, are gradually set into motion by the flow. During this entrainment regime, the plume is strongly skewed in the direction of propagation and continuously accelerates while spreading nonlinearly. With time, the skewness of the plume eventually reaches a maximum value before decreasing. This marks the transition to an advection-diffusion regime in which the plume becomes increasingly symmetrical, spreads linearly, and advances at constant velocity. We analytically derive the expressions of the position, the variance, and the skewness of the plume and investigate their asymptotic regimes. Our model assumes steady state. In the field, however, bed load transport is intermittent. We show that the asymptotic regimes become insensitive to this intermittency when expressed in terms of the distance traveled by the plume. If this finding applies to the field, it might provide an estimate for the average bed load transport rate.

  17. Development and automation of a novel NET-PET tracer: [11C]Me@APPI.

    Science.gov (United States)

    Mark, Christina; Bornatowicz, Birgit; Mitterhauser, Markus; Hendl, Matthias; Nics, Lukas; Haeusler, Daniela; Lanzenberger, Rupert; Berger, Michael L; Spreitzer, Helmut; Wadsak, Wolfgang

    2013-02-01

    The norepinephrine transporter (NET) is an important target for research in neurology and psychology and is involved in the pathophysiology of many neurodegenerative diseases such as Alzheimer's disease and attention deficient hyperactivity disorder. For visualization of NET abundance and deregulation, a novel PET tracer--[(11)C]Me@APPI--has been developed. For precursor synthesis, a 4-step synthesis starting from N-phenyl-o-phenylenediamine was set up. Radiosynthesis was established and optimized using standard methods and subsequently automated in a GE TRACERlabFx C Pro synthesizer. Preclinical testing was performed comprising affinity and selectivity testing on human membranes as well as stability and blood-brain-barrier-penetration using in-vitro models. Precursor molecule (APPI:0) and reference compound (Me@APPI) were synthesized with 26.5% and 21.4% overall yield, respectively. So far, 1.25±0.72 GBq [(11)C]Me@APPI with 54.35±7.80 GBq/μmol specific activity were produced (n=11). Affinity of reference compounds was determined as 8.08±1.75 nM for Me@APPI and 19.31±2.91 nM for APPI:0, respectively (n≥9). IAM-chromatography experiments (n=3) revealed a P(m) value of 1.51±0.34 for Me@APPI. Stability testing using human liver microsomes revealed that 99.5% of the tracer was found to be still intact after 60 minutes (n=4). Present data indicate that [(11)C]Me@APPI has promising properties to become a clinically useful NET-PET-tracer. Further in-vitro and in-vivo evaluations are currently under way. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Development and automation of a novel NET-PET tracer: [11C]Me@APPI

    International Nuclear Information System (INIS)

    Mark, Christina; Bornatowicz, Birgit; Mitterhauser, Markus; Hendl, Matthias; Nics, Lukas; Haeusler, Daniela; Lanzenberger, Rupert; Berger, Michael L.; Spreitzer, Helmut; Wadsak, Wolfgang

    2013-01-01

    Introduction: The norepinephrine transporter (NET) is an important target for research in neurology and psychology and is involved in the pathophysiology of many neurodegenerative diseases such as Alzheimer's disease and attention deficient hyperactivity disorder. For visualization of NET abundance and deregulation, a novel PET tracer – [ 11 C]Me@APPI – has been developed. Methods: For precursor synthesis, a 4-step synthesis starting from N-phenyl-o-phenylenediamine was set up. Radiosynthesis was established and optimized using standard methods and subsequently automated in a GE TRACERlabFx C Pro synthesizer. Preclinical testing was performed comprising affinity and selectivity testing on human membranes as well as stability and blood–brain-barrier-penetration using in-vitro models. Results: Precursor molecule (APPI:0) and reference compound (Me@APPI) were synthesized with 26.5% and 21.4% overall yield, respectively. So far, 1.25 ± 0.72 GBq [ 11 C]Me@APPI with 54.35 ± 7.80 GBq/μmol specific activity were produced (n = 11). Affinity of reference compounds was determined as 8.08 ± 1.75 nM for Me@APPI and 19.31 ± 2.91 nM for APPI:0, respectively (n ≥ 9). IAM-chromatography experiments (n = 3) revealed a P m value of 1.51 ± 0.34 for Me@APPI. Stability testing using human liver microsomes revealed that 99.5% of the tracer was found to be still intact after 60 minutes (n = 4). Conclusion: Present data indicate that [ 11 C]Me@APPI has promising properties to become a clinically useful NET-PET-tracer. Further in-vitro and in-vivo evaluations are currently under way

  19. Online Resources

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Online Resources. Journal of Genetics. Online Resources. Volume 97. 2018 | Online resources. Volume 96. 2017 | Online resources. Volume 95. 2016 | Online resources. Volume 94. 2015 | Online resources. Volume 93. 2014 | Online resources. Volume 92. 2013 | Online resources ...

  20. Gas Phase Nanoparticle Synthesis

    Science.gov (United States)

    Granqvist, Claes; Kish, Laszlo; Marlow, William

    This book deals with gas-phase nanoparticle synthesis and is intended for researchers and research students in nanomaterials science and engineering, condensed matter physics and chemistry, and aerosol science. Gas-phase nanoparticle synthesis is instrumental to nanotechnology - a field in current focus that raises hopes for environmentally benign, resource-lean manufacturing. Nanoparticles can be produced by many physical, chemical, and even biological routes. Gas-phase synthesis is particularly interesting since one can achieve accurate manufacturing control and hence industrial viability.

  1. First research coordination meeting of the coordinated research project on validation of tracers and software for interwell investigations. Meeting report

    International Nuclear Information System (INIS)

    2004-01-01

    Interwell tracer test is an important reservoir engineering tool for secondary and tertiary recovery of oil. Most of the oil fields in many developing countries are in the stage of secondary recovery. Moreover, the oil industry remains at priority in these countries. It is therefore appropriate that further efforts should be channeled primarily towards promoting the radiotracer technology in this priority sector. The main purpose of interwell tracer tests in oil and geothermal reservoirs is to monitor qualitatively and quantitatively the fluid connections between injection and production wells and to map the flow field. Tracer is added into injection fluid via an injection well and observed in the surrounding production wells. Tracer response is then used to describe the flow pattern and obtain better understanding of the reservoir. This is important knowledge in order to optimize oil recovery. Radioactive tracers have been playing an important role in interwell tests because of their advantages, such as high sensitivity, stability and selectivity. Most of the information given by the tracer response curves cannot be obtained by means of other techniques. Interwell tracer test is also used in geothermal reservoirs to get better understanding of reservoir geology and to optimize production and re-injection program. High temperature geothermal resources are normally used for power generation. Whereas, middle and low temperature reservoirs are developing for civil living such as room heating and warm water supplying. Geothermal resource is now well recognized as a green and important part of follow-up energy sources in many developing countries. Over the years, the IAEA has contributed substantial funding and effort to the development of radiotracer technology and its transfer to developing Member States. Significant progress has been made enabling the countries to establish national radiotracer groups with an indigenous capacity to sustain and develop applications

  2. TMI cable tracer operation and maintenance manual for assembly 417910

    International Nuclear Information System (INIS)

    Sumstine, R.L.

    1983-11-01

    This manual provides technical information and instructions to operate and maintain the cable tracer designed for the Three Mile Island (TMI) Unit 2 Reactor Building. The TMI cable tracer was developed to allow TMI personnel to trace cables in cable trays that may be tested or sectioned for destructive examination

  3. Methane emission quantification from landfills using a double tracer approach

    DEFF Research Database (Denmark)

    Scheutz, Charlotte; Samuelsson, J.; Fredenslund, Anders Michael

    2007-01-01

    A tracer method was successfully used for quantification of the whole methane (CH4) emission from Fakse landfill. By using two different tracers the emission from different sections of the landfill could be quantified. Furthermore, is was possible to determine the emissions from local on site...

  4. Toxicity of fluorescent tracers and their degradation byproducts

    Directory of Open Access Journals (Sweden)

    Philippe Gombert

    2017-01-01

    Full Text Available Tracer tests are frequently used to delineate catchment area of water supply springs in karstic zones. In the karstic chalk of Normandy, the main tracers used are fluorescent: uranine, sulforhodamine B, naphtionate, and Tinopal®. In this area, a statistical analysis shows that less than half of the injected tracers joins the monitored restitution points and enters the drinking water system where they undergo chlorination. Most of the injected tracers is absorbed in the rock matrix or is thrown out of the aquifer via karstic springs: then it can join superficial waters where it is degraded due to the sun and air action. The paper presents firstly the laboratory degradation of a first batch of fluorescent tracers in contact with chlorine, in order to simulate their passage through a water treatment system for human consumption. A second batch of the same tracers is subjected to agents of natural degradation: ultraviolet illumination, sunlight and air sparging. Most tracers is degraded, and toxicity and ecotoxicity tests (on rats, daphniae and algae are performed on degradation byproducts. These tests do not show any acute toxicity but a low to moderate ecotoxicity. In conclusion, the most used fluorescent tracers of the Normandy karstic chalk and their artificial and natural degradation byproducts do not exhibit significant toxicity to humans and the aquatic environment, at the concentrations generally noted at the restitution points.

  5. National Biomedical Tracer Facility. Project definition study

    Energy Technology Data Exchange (ETDEWEB)

    Schafer, R.

    1995-02-14

    We request a $25 million government-guaranteed, interest-free loan to be repaid over a 30-year period for construction and initial operations of a cyclotron-based National Biomedical Tracer Facility (NBTF) in North Central Texas. The NBTF will be co-located with a linear accelerator-based commercial radioisotope production facility, funded by the private sector at approximately $28 million. In addition, research radioisotope production by the NBTF will be coordinated through an association with an existing U.S. nuclear reactor center that will produce research and commercial radioisotopes through neutron reactions. The combined facilities will provide the full range of technology for radioisotope production and research: fast neutrons, thermal neutrons, and particle beams (H{sup -}, H{sup +}, and D{sup +}). The proposed NBTF facility includes an 80 MeV, 1 mA H{sup -} cyclotron that will produce proton-induced (neutron deficient) research isotopes.

  6. Use of radioactive tracers in chemical reactions

    International Nuclear Information System (INIS)

    Paci, B.; Saiki, M.

    1979-01-01

    A method for the determination of small quantities of nickel by using radioactive tracers is presented. An analytical application of the displacement reaction between and zinc-ethylenediaminetetraacetate, (Zn-EDTA), labelled with 65 Zn is investigated. This method is based on the extraction of radioactive zinc, displaced by nickel from the zinc chelate, into a dithizone-carbon tetrachloride solution and the subsequent measurement of the activity of an aliquot of the extract. It is shown that the method is very sentitive and nickel can be measured in concentrations as small as 0,1μg/ml or even less, depending on the specific activity of the radioreagent used. The precision and accuracy of the method are determined. An attempt to eliminate the problem of interference by using masking agents or by means of a previous separation of nickel and other interfereing metals, is also made. (Author) [pt

  7. New SPECT and PET dementia tracers

    International Nuclear Information System (INIS)

    Vergote, J.; Chalon, S.; Emond, P.; Vercouillie, J.; Guilloteau, D.; Vergote, J.; Guilloteau, D.; Pappata, J.S.

    2009-01-01

    Single photon emission tomography (SPECT) and positron emission tomography (PET) are techniques to study in vivo neurotransmitter systems, neuro inflammation and amyloid deposits in normal human brain and in dementia. These methods used to explore the integrity of dopaminergic, cholinergic and serotonergic systems in Alzheimer's disease and in other dementias allowed to understand how the neurotransmission was modified in these disorders. Progress in the understanding of pathophysiological and clinical signs of dementia requires an evolution of the radioligands used to carry out an increasingly early and differential diagnosis in addition to monitoring the progression of disease and the effects of therapies. New emerging radiotracers for neuro inflammation or amyloid deposits are essential. In this article, new SPECT and PET tracers are presented. (authors)

  8. Positron emission tomography tracers for imaging angiogenesis

    International Nuclear Information System (INIS)

    Haubner, Roland; Beer, Ambros J.; Wang, Hui; Chen, Xiaoyuan

    2010-01-01

    Position emission tomography imaging of angiogenesis may provide non-invasive insights into the corresponding molecular processes and may be applied for individualized treatment planning of antiangiogenic therapies. At the moment, most strategies are focusing on the development of radiolabelled proteins and antibody formats targeting VEGF and its receptor or the ED-B domain of a fibronectin isoform as well as radiolabelled matrix metalloproteinase inhibitors or α v β 3 integrin antagonists. Great efforts are being made to develop suitable tracers for different target structures. All of the major strategies focusing on the development of radiolabelled compounds for use with positron emission tomography are summarized in this review. However, because the most intensive work is concentrated on the development of radiolabelled RGD peptides for imaging α v β 3 expression, which has successfully made its way from bench to bedside, these developments are especially emphasized. (orig.)

  9. Use of radioactive tracers in chemical reactions

    International Nuclear Information System (INIS)

    Paci, B.

    1979-01-01

    A method for the determination of small quantities of nickel using radioactive tracers is presented. An analytical application of the displacement reaction between nickel and zinc ethylenediaminetetraacetate labeled with zinc-65 is pursued. This method is based on the extraction of radioactive zinc displaced by nickel from the zinc chelate into a dithizone-carbon tetracloride solution and the subsequent measurement of the activity of an aliquot of the extract. The method is very sensitive and nickel can be measured in concentrations as small as 0.1μg/ml or even less, depending on the specific activity of the radioreagent used. The precision and the accuracy of the method are determined. The problem of interferences, trying to eliminate them by using masking agents or by means of a previous separation between nickel and other interfering metals, is also investigated [pt

  10. National Biomedical Tracer Facility. Project definition study

    International Nuclear Information System (INIS)

    Schafer, R.

    1995-01-01

    We request a $25 million government-guaranteed, interest-free loan to be repaid over a 30-year period for construction and initial operations of a cyclotron-based National Biomedical Tracer Facility (NBTF) in North Central Texas. The NBTF will be co-located with a linear accelerator-based commercial radioisotope production facility, funded by the private sector at approximately $28 million. In addition, research radioisotope production by the NBTF will be coordinated through an association with an existing U.S. nuclear reactor center that will produce research and commercial radioisotopes through neutron reactions. The combined facilities will provide the full range of technology for radioisotope production and research: fast neutrons, thermal neutrons, and particle beams (H - , H + , and D + ). The proposed NBTF facility includes an 80 MeV, 1 mA H - cyclotron that will produce proton-induced (neutron deficient) research isotopes

  11. Project definition study for the National Biomedical Tracer Facility

    Energy Technology Data Exchange (ETDEWEB)

    Roozen, K.

    1995-02-15

    The University of Alabama at Birmingham (UAB) has conducted a study of the proposed National Biomedical Tracer Facility (NBTF). In collaboration with General Atomics, RUST International, Coleman Research Corporation (CRC), IsoMed, Ernst and Young and the advisory committees, they have examined the issues relevant to the NBTF in terms of facility design, operating philosophy, and a business plan. They have utilized resources within UAB, CRC and Chem-Nuclear to develop recommendations on environmental, safety and health issues. The Institute of Medicine Panel`s Report on Isotopes for Medicine and the Life Sciences took the results of prior workshops further in developing recommendations for the mission of the NBTF. The IOM panel recommends that the NBTF accelerator have the capacity to accelerate protons to 80 MeV and a minimum of 750 microamperes of current. The panel declined to recommend a cyclotron or a linac. They emphasized a clear focus on research and development for isotope production including target design, separation chemistry and generator development. The facility needs to emphasize education and training in its mission. The facility must focus on radionuclide production for the research and clinical communities. The formation of a public-private partnership resembling the TRIUMF-Nordion model was encouraged. An advisory panel should assist with the NBTF operations and prioritization.

  12. Project definition study for the National Biomedical Tracer Facility

    International Nuclear Information System (INIS)

    Roozen, K.

    1995-01-01

    The University of Alabama at Birmingham (UAB) has conducted a study of the proposed National Biomedical Tracer Facility (NBTF). In collaboration with General Atomics, RUST International, Coleman Research Corporation (CRC), IsoMed, Ernst and Young and the advisory committees, they have examined the issues relevant to the NBTF in terms of facility design, operating philosophy, and a business plan. They have utilized resources within UAB, CRC and Chem-Nuclear to develop recommendations on environmental, safety and health issues. The Institute of Medicine Panel's Report on Isotopes for Medicine and the Life Sciences took the results of prior workshops further in developing recommendations for the mission of the NBTF. The IOM panel recommends that the NBTF accelerator have the capacity to accelerate protons to 80 MeV and a minimum of 750 microamperes of current. The panel declined to recommend a cyclotron or a linac. They emphasized a clear focus on research and development for isotope production including target design, separation chemistry and generator development. The facility needs to emphasize education and training in its mission. The facility must focus on radionuclide production for the research and clinical communities. The formation of a public-private partnership resembling the TRIUMF-Nordion model was encouraged. An advisory panel should assist with the NBTF operations and prioritization

  13. Suitable activated carbon-13 tracer techniques

    International Nuclear Information System (INIS)

    Zhang Weicheng; Peng Xiuru; Wang Yuhua

    1995-12-01

    Feasibility and applicability studies of the proton induced gamma ray emission (PIGE) have been performed. The graphite was firstly bombarded at various proton energies to determine gamma ray yield (and, thus, sensitivities) for the reaction of interest. The accuracy for the determination of 13 C abundance was checked, and the precision with which this value and ratios 13 C/ 12 C may be obtained was established by repetitive analysis samples. The performance of different standards in this determination was assessed. The mathematical treatment was developed for the determination of 13 C abundance in tracer studies, and to derive the equations that govern this method of analysis from first principles, to arrive finally at a simple expression by virtue of the observed regularities. The system was calibrated by measuring the gamma ray yield form the 12 C (p, γ) 13 N and 13 C(p,γ) 14 N reaction as a function of known 13 C enrichment. Using this experimentally determined calibration curve, unknown materials can be assayed. This technique is applicable to the analysis of samples with 13 C enrichments between 0.1% and 90%. The samples of human breath natural samples were analyzed against graphite and Cylinder CO 2 standards. Relative standard deviations were 13 C abundance, an increase in 13 C per cent isotopic abundance from the natural 1.11% (average) to only 1.39% may be ascertained. Finally, PIGE is compared with more classical techniques for analysis of 13 C tracer experiments. Ease and speed are important advantages of this technique over mass spectrometry, and its error is compatible with the natural variation of biological results. (9 refs., 11 figs., 9 tabs.)

  14. Rate equations for tracer studies in recirculating reactors

    Energy Technology Data Exchange (ETDEWEB)

    Happel, J [Columbia Univ., New York (USA). Dept. of Chemical Engineering

    1974-10-01

    The employment of isotopic tracers is a useful technique for gaining insight into the rate controlling steps of a complex chemical reaction such as is frequently encountered in heterogeneous catalysis. An effective procedure has been to superpose tracer transfer on a reaction which is occurring under steady state conditions. If tracer transfer is employed in this fashion it is often possible to assess the individual step velocities in an assumed reaction mechanism. If transient transfer of tracer is now introduced it is possible in addition to estimate surface concentrations of chemisorbed species. The purpose of the present paper is to present the mathematical relationships involved when transfer of the tracer is not differential in the investigation. For this purpose a simple example is chosen to illustrate the various possibilities involved.

  15. Molecular dynamics investigation of tracer diffusion in a simple liquid

    International Nuclear Information System (INIS)

    Ould-Kaddour, F.; Barrat, J.L.

    1991-05-01

    Extensive Molecular-Dynamics (MD) simulations have been carried out for a model trace-solvent system made up of 100 solvent molecules and 8 tracer molecules interacting through truncated Lennard-Jones potentials. The influence of the size ratio between solute and solvent, of their mass ratio and of the solvent viscosity on the diffusivity of a small tracer were investigated. Positive deviations from a Stokes-Einstein behaviour are observed, in qualitative agreement with experimental observations. It was also observed that as tracer and solvent become increasingly dissimilar, their respective dynamics becomes decoupled. We suggest that such decouplings can be interpreted by writing their mobility of the tracer as the sum of two terms, the first one arising from a coupling between tracer dynamics and hydrodynamics modes of the solvent, and the second one describing jump motion in a locally nearly frozen environment. (author). 17 refs, 4 figs, 6 tabs

  16. Rate equations for tracer studies in recirculatinng reactors

    International Nuclear Information System (INIS)

    Happel, J.

    1974-01-01

    The employment of isotopic tracers is a useful technique for gaining insight into the rate controlling steps of a complex chemical reaction such as is frequently encountered in heterogeneous catalysis. An effective procedure has been to superpose tracer transfer on a reaction which is occurring under steady state conditions. If tracer transfer is employed in this fashion it is often possible to assess the individual step velocities in an assumed reaction mechanism. If transient transfer of tracer is now introduced it is possible in addition to estimate surface concentrations of chemisorbed species. The purpose of the present paper is to present the mathematical relationships involved when transfer of the tracer is not differential in the investigation. For this purpose a simple example is chosen to illustrate the various possibilities involved. (auth.)

  17. Benefits of important industrial tracer applications in the GDR

    International Nuclear Information System (INIS)

    Leonhardt, J.W.; Goeldner, R.; Koennecke, H.G.; Kupsch, H.; Luther, D.; Otto, R.; Reinhardt, R.; Ulrich, H.

    1990-01-01

    Tracers can be used to label substances or objects in order to discriminate between them, to follow their movement, to record changes of concentration and distribution between phases, etc. The main advantages of tracer investigations are the contactless recording of signals without influencing the observed process (also under rigorous operation conditions), the high detection sensitivity, the large number of available tracer nuclides (problems of all branches of industry can be solved) and the fact that tracer investigation can be carried out on operating production units, so that they provide valuable checks of the validity of design and process data. The cost-to-benefit ratio can be as low as 1:50. In the following some selected examples of tracer applications and their benefits will be presented. (orig./BBR) [de

  18. 3-D migration experiment - report 2: Instrumentation and tracers

    International Nuclear Information System (INIS)

    Abelin, H.; Birgersson, L.; Gidlund, J.

    1987-11-01

    This report is one of the four reports describing the Stripa 3D experiment where water and tracer flow has been monitored in a specially excavated drift in the Stripa mine. The experiment was performed in a specially excavated drift at the 360 m level in granite. The whole ceiling and upper part of the walls were covered with more than 350 individual plastic sheets where the water flow into the drift could be collected. 11 different tracers were injected at distances between 11 and 50 m from the ceiling of the drift. The flow rate and tracer monitoring was kept up for more than two years. The tracer breakthrough curves and flow rate distributions were used to study the flow paths, velocities, hydraulic conductivities, dispersivities and channeling effects in the rock. The report describes the instrumentation developed and used as well as the tracers that were tested and used in the experiment. (orig.)

  19. Tracer migration experiments in the Stripa mine 1980-1991

    International Nuclear Information System (INIS)

    Birgersson, L.; Widen, H.; Aagren, T.; Neretnieks, I.

    1992-05-01

    During more than 10 years, tracer experiments have been performed in the Stripa mine as part of the Stripa project to investigate the properties of both 'average' fractured rock and fracture zones. Experiments have been performed that have ranged from a few decimeters, to examine the diffusion into the rock matrix, up to tracer migration to a drift more than 50 meters from the injection point. This report compiles the results and experience that have been gained from all these tracer experiments. The experiments that are described in this report are: * The in-situ diffusion experiment where simultaneous flow and diffusion of tracers in undisturbed rock were studied over more than 3 years to validate diffusivities obtained under laboratory conditions. * Migration in a single fracture where water flow distribution and tracer transport were studied using both conservative and sorbing tracers over migration distances up to 10 meters. * The 3-D migration experiment where water inflow and tracer transport to a drift covered with 350 plastic sheet were investigated to get information on flow porosity, dispersion and channeling. The transport distances were between 10 and 56 meters from the injection points to the drift. * The channeling experiments in which the aim was to examine the channeling properties of single fractures in detail. Pressure pulse tests and tracer experiments were performed over a distances of 2 meters. * The tracer migration experiment in the validation drift where the tracer were injected mainly in a fracture zone and the collection was inside both a drift covered with plastic sheets similar to in the 3-D experiment as well as in a borehole. The distances between injection and sampling location were between 10 and 25 meters. (57 refs.) (au)

  20. Methods and systems using encapsulated tracers and chemicals for reservoir interrogation and manipulation

    Science.gov (United States)

    Roberts, Jeffery; Aines, Roger D; Duoss, Eric B; Spadaccini, Christopher M

    2014-11-04

    An apparatus, method, and system of reservoir interrogation. A tracer is encapsulating in a receptacle. The receptacle containing the tracer is injected into the reservoir. The tracer is analyzed for reservoir interrogation.

  1. Bromide as a tracer for studying water movement and nitrate displacement in soils: comparison with stable isotope tracers

    International Nuclear Information System (INIS)

    Russow, R.; Knappe, S.

    1999-01-01

    Tracers are an ideal means of studying water movement and associated nitrate displacement. Often bromide is preferred as a tracer because it is considered a representative tracer for water and because, being a conservative tracer (i.e. not involved in chemical and biological soil processes), it can be used for studying anion transport in soils. Moreover, it is less expensive and easier to measure than the stable isotopes deuterium and 15 N. Its great advantage over radioactive tracers (e.g. tritium), which outweighs their extreme sensitivity and ease of measurement and which it has in common with stable isotopes, is that it does not require radiation protection measures. However, there are also constraints on the use of bromide as a tracer in soil/water/plant systems. Our own studies on different soils using D 2 O, bromide and [ 15 N]-nitrate in lysimeters suggest that the above assumptions on bromide tracers need not always be valid under conditions as they prevail in biologically active soils. As the present paper shows, these studies permit a good assessment of the possibilities and limits to these tracers [de

  2. Herpes - resources

    Science.gov (United States)

    Genital herpes - resources; Resources - genital herpes ... following organizations are good resources for information on genital herpes : March of Dimes -- www.marchofdimes.org/complications/sexually- ...

  3. Multiscale investigation of catchment functioning using environmental tracers: Insights from the mesoscale Attert basin in Luxembourg

    Science.gov (United States)

    Wrede, S.; Pfister, L.; Krein, A.; Bogaard, T. A.; Savenije, H. H. G.; Uhlenbrook, S.

    2009-04-01

    Experimental hydrology focuses traditionally on field investigations at smaller spatial and temporal scales and research is driven by small-scale, detailed and complex investigations of densely instrumented research sites. However, to improve operational water management and protection of water resources at the river basin scale, it is necessary to study the hydrological processes across a range of scales. Empirical studies investigating catchment structure and functioning across multiple scales are still rare and urgently needed. Besides geomorphologic and climatic catchment descriptors, environmental tracers have been recognized as a fundamental tool in experimental hydrology to assess the scaling gap, as they provide an independent and integrative perspective of catchment functioning and scaling. A three year tracer study is being carried out in the Attert river basin in Luxembourg to identify how major controls of runoff generation change across scales and to investigate the spatial and temporal functioning of larger basins. The mesoscale (300 km²) Attert catchment is located in the Midwestern part of Luxembourg and lies at the transition zone of contrasting bedrock lithology that is a major control for runoff generation: The Northern part is characterized by Devonian schist of the Ardennes massif, while sedimentary deposits of sandstone and marls dominate in the Southern part of the basin. Major hydrochemical tracers including stable water isotopes were grab sampled fortnightly and, where possible, also event-based at 13 nested stream locations ranging in size from 0.5 to 300 km² throughout the basin. Results using Deuterium and a range of hydrochemical tracers confirm the major role of bedrock lithology for runoff response of different geological parts of the basins: Hydrological response of schistose basins is characterized by seasonal variation and a delayed shallow groundwater component originating from a saprolitic zone, sandstone basins exhibit a

  4. A 99Tcm labeled HYNIC peptide 'tracer' libraries on continuous cellulose membrane supports

    International Nuclear Information System (INIS)

    Zeng Jun; Liu Ciyi; Xie Wenhui; Hu Silong; Jin Xiumu

    2007-01-01

    Objective: The interference of bifunctional ligands with activities of small peptides has long been recognized. To solve the problem, the hydrazine-nicotinamide (HYNIC) conjugated peptide 'tracer' libraries were synthesized on a continuous cellulose membrane support and the 99 Tc m labeled heat shock protein 70 (HSP70) binding peptides were identified by screening libraries with HSP70. Methods: Octapeptide libraries were prepared by manual spot synthesis. HYNIC peptides were C terminally attached to cellulose via a (β-Ala) 2 spacer. For screening, the cellulose membranes were incubated with human HSP70 (or biotin labeled HSP70) after nonspecific blocking. Alkaline phosphatase labeled streptavidin and Ab against HSP70 were used for the detection of HSP70 binding. Human lung cancer cell lines (A549 and H460) were cultured in RPMI1640 medium supplemented with 10% fetal calf serum and antibiotics. For in vivo test, 2 x l0 5 cells were subcutaneously transplanted into the chest of female nude mice. Results: Quality control of HYNIC peptide libraries was good as carried out by 99 Tc m labeling. Because peptide NLLRLTG had high affinity for HSP70 family members, 99 Tc m -HYNIC-NLLRLTG was used as the control. Fifteen HYNIC peptides were found with HSP70 binding property. Among them, eight peptides had higher uptake (percentage activity of injection dose pergram of tissue, %ID/g) values than 99 Tc m -HYNIC-NLLRLTG in tumor. 99 Tc m -HYNIC-QGVLTGTR had the best distribution in tumors. Six hours after injection, the %ID/g values of 99 Tc m HYNIC-QGVLTGTR and 99 Tc m -HYNIC-NLLRLTG in tumor were (1.15±0.32)% ID/g and (0.75±0.24)% ID/g respectively. In vivo replace studies and heat shock stress of tumors demonstrated that 99 Tc m -HYNIC-QGVLTGTR was the HSP70 binding peptide compound, but not 99 Tc m -HYNIC-NLLRLTG. Conclusions: The identification of 99 Tc m labeled HSP70 binding peptides from HYNIC conjugated octapeptide libraries facilitated the hypothesis of the 'tracer

  5. Ground water pollution by roof runoff infiltration evidenced with multi-tracer experiments.

    Science.gov (United States)

    Ammann, Adrian A; Hoehn, Eduard; Koch, Sabine

    2003-03-01

    The infiltration of urban roof runoff into well permeable subsurface material may have adverse effects on the ground water quality and endanger drinking water resources. Precipitation water from three different roofs of an industrial complex was channelled to a pit and infiltrated into a perialpine glaciofluvial gravel-and-sand aquifer. A shaft was constructed at the bottom of the pit and equipped with an array of TDR probes, lysimeters and suction cups that allowed measuring and sampling soil water at different depths. A fast infiltration flow was observed during natural rainfall events and during artificial infiltration experiments. For a better understanding of the behaviour of contaminants, experiments were conducted with cocktails of compounds of different reactivity (ammonium, strontium, atratone) and of non-reactive tracers (uranine, bromide, naphthionate), which represent different classes of pollutants. The experiment identified cation exchange reactions influencing the composition of the infiltrating water. These processes occurred under preferential flow conditions in macropores of the material. Measuring concentration changes under the controlled inflow of tracer experiments, the pollution potential was found to be high. Non-reactive tracers exhibited fast breakthrough and little sorption.

  6. Estimating the spatial distribution of artificial groundwater recharge using multiple tracers.

    Science.gov (United States)

    Moeck, Christian; Radny, Dirk; Auckenthaler, Adrian; Berg, Michael; Hollender, Juliane; Schirmer, Mario

    2017-10-01

    Stable isotopes of water, organic micropollutants and hydrochemistry data are powerful tools for identifying different water types in areas where knowledge of the spatial distribution of different groundwater is critical for water resource management. An important question is how the assessments change if only one or a subset of these tracers is used. In this study, we estimate spatial artificial infiltration along an infiltration system with stage-discharge relationships and classify different water types based on the mentioned hydrochemistry data for a drinking water production area in Switzerland. Managed aquifer recharge via surface water that feeds into the aquifer creates a hydraulic barrier between contaminated groundwater and drinking water wells. We systematically compare the information from the aforementioned tracers and illustrate differences in distribution and mixing ratios. Despite uncertainties in the mixing ratios, we found that the overall spatial distribution of artificial infiltration is very similar for all the tracers. The highest infiltration occurred in the eastern part of the infiltration system, whereas infiltration in the western part was the lowest. More balanced infiltration within the infiltration system could cause the elevated groundwater mound to be distributed more evenly, preventing the natural inflow of contaminated groundwater. Dedicated to Professor Peter Fritz on the occasion of his 80th birthday.

  7. The use of bromine as a tracer for studying infiltrations in mining processes

    International Nuclear Information System (INIS)

    Diaz, F; Andonie, O; Rojas, X

    2003-01-01

    The impact of mining activity on underground water is becoming increasingly important because of the scarcity of the resource and due to the different use if there is water under the mining. Once the resource is affected the source of infiltration should be identified in all the processes and systems that are involved in the production system in order to take the appropriate preventive or remedial measures, which should also be the most efficient ones. Tracers play an important role in studying infiltration from mining processes to underground bodies of water. Natural chemical and isotopic tracers can identify the hydrogeological setting and help to establish supported hypotheses about the possible origin of the infiltrations. After the different ideas about the processes or systems that could be infiltrated are presented, the application of additional artificial tracers can resolve any doubts This work presents the use of bromine as a tracer for such studies, because of its specific characteristics as a good tracer in water with low interaction in porous surroundings, generally, and its determination by Neutron Activation Analyzers (NAA) due to its low limits of detection and the technique's precision and accuracy for use at reasonable costs. Given that for this type of study a large number of samples are necessary and that it should be carried out in a time period that does not surpass the duration of the process (a few months), a change had to be made in the methodology usually used for the NAA, which included taking a fraction of significantly less sample while meeting the power requirements for differentiating small changes in concentrations between samples. With this modification a larger number of samples can be irradiated in available positions for these purposes in the RECH-1 and the requirements for the number of samples and response time can be met. After the practical performance of this modification, a comparison between both methodologies was carried

  8. Quantitative Analysis of Karst Conduit Structure Parameters and Hydraulic Parameters Based on Tracer Test

    Science.gov (United States)

    Qiang, Z.; Zhiqiang, Z.; Xu, M.; Jinyu, S.; Jihong, Q.

    2017-12-01

    The Old Town of Lijiang is famous as the world cultural heritage since 1997, while characterized by its ancient buildings and natural scenery, water is the soul of the town. Around Heilongtan Springs, there are a large quantity of springs at the Old Town of Lijiang , which is an important part of the World Cultural Heritage. Heilongtan Springs is 2420m above the sea level, the annual variation of the flow rate varies greatly (0 8042 x 104 m3 / year). Recharge area Jiuzihai depressions is 6km long, 3km wide and 2800m above sea level, as main karst water recharge area karst funnel and the sink hole are developing on this planation surface, in the research area medium to thick layers of limestone made up Beiya formation (T2b) of Triassic system distributed widely, karst is strongly developed and the fissure caves water occurrence. In order to exploring the application of tracer test in karst hydrogeology, a tracer test was conducted from Jiuzihai depressions to Ganze Spring. Based on the hydrogeological conditions in the study area, tracer test was used for analysis of groundwater connectivity and flow field characteristics, quantitative analysis of Tracer Breakthrough Curves (BTC) with code Qtracer2. The results demonstated that there are hydraulic connection between Jiuzihai depressions with Ganze Spring, and there are other karst conduits in this area. The longitudinal dispersivity coefficient is 0.24 m2/s, longitudinal dispersivity is 12.06m, flow-channel volume is 3.08×104 m3, flow-channel surface area is 3.27×107m2, mean diameter is 1.42m, Reynolds number is 25187, Froude number is 0.0061, respectively. The groundwater in this area is in a slow turbulent state. The results are of great significance to understand the law of groundwater migration, establish groundwater quality prediction model and exploit karst water resources effectively.

  9. The European Tracer Experiment - experimental results and database

    International Nuclear Information System (INIS)

    Nodop, K.; Connolly, R.; Girardi, F.

    1997-01-01

    As part of the European Tracer Experiment (ETEX) two successful atmospheric experiments were carried out in October and November, 1994. Perfluorocarbon (PFC) tracers were released into the atmosphere in Monterfil, Brittany, and air samples were taken at 168 stations in 17 European countries for 72 hours after the release. Upper air tracer measurements were made from three aircraft. During the first experiment a westerly air flow transported the tracer plume north-eastwards across Europe. During the second release the flow was eastwards. The results from the ground sampling network allowed the determination of the cloud evolution as far as Sweden, Poland and Bulgaria. Typical background concentrations of the tracer used are around 5 to 7 fl/l in ambient air. Concentrations in the plume ranged from 10 to above 200 fl/l. The tracer release characteristics, the tracer concentrations at the ground and in upper air, the routine and additional meteorological observations at the ground level and in upper air, trajectories derived from constant-level balloons and the meteorological input fields for long-range transport (LRT) models are assembled in the ETEX database. The ETEX database is accessible via the Internet

  10. Methods of 15N tracer research in biological systems

    International Nuclear Information System (INIS)

    Hirschberg, K.; Faust, H.

    1985-01-01

    The application of the stable isotope 15 N is of increasing importance in different scientific disciplines, especially in medicine, agriculture, and the biosciences. The close correlation between the growing interest and improvements of analytical procedures resulted in remarkable advances in the 15 N tracer technique. On the basis of the latest results of 15 N tracer research in life sciences and agriculture methods of 15 N tracer research in biological systems are compiled. The 15 N methodology is considered under three headings: Chemical analysis with a description of methods of sample preparation (including different separation and isolation methods for N-containing substances of biological and agricultural origin) and special procedures converting ammonia to molecular nitrogen. Isotopic analysis with a review on the most important methods of isotopic analysis of nitrogen: mass spectrometry (including the GC-MS technique), emission spectrometry, NMR spectroscopy, and other analytical procedures. 15 N-tracer techniques with a consideration of the role of the isotope dilution analysis as well as different labelling techniques and the mathematical interpretation of tracer data (modelling, N turnover experiments). In these chapters also sources of errors in chemical and isotopic analysis, the accuracy of the different methods and its importance on tracer experiments are discussed. Procedures for micro scale 15 N analysis and aspects of 15 N analysis on the level of natural abundance are considered. Furthermore some remarks on isotope effects in 15 N tracer experiments are made. (author)

  11. A tracer diffusion model derived from microstructure

    International Nuclear Information System (INIS)

    Lehikoinen, Jarmo; Muurinen, Arto; Olin, Markus

    2012-01-01

    Document available in extended abstract form only. Full text of publication follows: Numerous attempts have been made to explain the tracer diffusion of various solutes in compacted clays. These attempts have commonly suffered from an inability to describe the diffusion of uncharged and charged solutes with a single unified model. Here, an internally consistent approach to describing the diffusion of solutes in a heterogeneous porous medium, such as compacted bentonite, in terms of its microstructure is presented. The microstructure is taken to be represented by a succession of unit cells, which consist of two consecutive regions (Do, 1996). In the first region, the diffusion is viewed to occur in two parallel paths: one through microcrystalline units (micropores) and the other through meso-pores between the microcrystalline units. Solutes exiting these two paths are then joined together to continue diffusing through the second, disordered, region, connecting the two adjacent microcrystalline units. Adsorption (incl. co-ion exclusion) is thought to occur in the micropores, whereas meso-pores and the disordered region accommodate free species alone. Co-ions are also assumed to experience transfer resistance into and out of the micropores, which is characterized in the model by a transmission coefficient. Although the model is not new per se, its application to compacted clays has never been attempted before. It is shown that in the limit of strong adsorption, the effective diffusivity is limited from above only by the microstructural parameters of the model porous medium. As intuitive and logical as this result may appear, it has not been proven before. In the limit of vanishing disordered region, the effective diffusivity is no longer explicitly constrained by any of the model parameters. The tortuosity of the diffusion path, i.e. the quotient of the actual diffusion path length in the porous-medium coordinates and the characteristic length of the laboratory frame

  12. Microbial DNA; a possible tracer of groundwater

    Science.gov (United States)

    Sugiyama, Ayumi; Segawa, Takuya; Furuta, Tsuyumi; Nagaosa, Kazuyo; Tsujimura, Maki; Kato, Kenji

    2017-04-01

    chemical materials dissolved in groundwater. Though viral particle was employed as a tracer to chase the movement of groundwater, it doesn't tell the chemical and physical environmental condition where the particle was incorporated into groundwater. Thus, we propose microbial DNA as a new tracer to track the route of groundwater.

  13. Contamination Tracer Testing With Seabed Rock Drills: IODP Expedition 357

    Science.gov (United States)

    Orcutt, B.; Bergenthal, M.; Freudenthal, T.; Smith, D. J.; Lilley, M. D.; Schneiders, L.; Fruh-Green, G. L.

    2016-12-01

    IODP Expedition 357 utilized seabed rock drills for the first time in the history of the ocean drilling program, with the aim of collecting intact core of shallow mantle sequences from the Atlantis Massif to examine serpentinization processes and the deep biosphere. This new drilling approach required the development of a new system for delivering synthetic tracers during drilling to assess for possible sample contamination. Here, we describe this new tracer delivery system, assess the performance of the system during the expedition, provide an overview of the quality of the core samples collected for deep biosphere investigations based on tracer concentrations, and make recommendations for future applications of the system.

  14. Contamination tracer testing with seabed drills: IODP Expedition 357

    Science.gov (United States)

    Orcutt, Beth N.; Bergenthal, Markus; Freudenthal, Tim; Smith, David; Lilley, Marvin D.; Schnieders, Luzie; Green, Sophie; Früh-Green, Gretchen L.

    2017-11-01

    IODP Expedition 357 utilized seabed drills for the first time in the history of the ocean drilling program, with the aim of collecting intact sequences of shallow mantle core from the Atlantis Massif to examine serpentinization processes and the deep biosphere. This novel drilling approach required the development of a new remote seafloor system for delivering synthetic tracers during drilling to assess for possible sample contamination. Here, we describe this new tracer delivery system, assess the performance of the system during the expedition, provide an overview of the quality of the core samples collected for deep biosphere investigations based on tracer concentrations, and make recommendations for future applications of the system.

  15. Determination of human muscle protein fractional synthesis rate

    DEFF Research Database (Denmark)

    Bornø, Andreas; Hulston, Carl J; van Hall, Gerrit

    2014-01-01

    In the present study, different MS methods for the determination of human muscle protein fractional synthesis rate (FSR) using [ring-(13)C6 ]phenylalanine as a tracer were evaluated. Because the turnover rate of human skeletal muscle is slow, only minute quantities of the stable isotopically...

  16. Positron emitting tracers for studies of cocaine

    International Nuclear Information System (INIS)

    Fowler, J.S.; Gatley, S.J.; MacGregor, R.R.; Wolf, A.P.; Yu, D.W.; Dewey, S.L.; Schlyer, D.J.; Volkow, N.D.; Bendriem, B.; Logan, J.

    1990-01-01

    The use of PET to study the behavior and mechanism of action of therapeutic drugs and substances of abuse can be approached from a number of perspectives. The most common approach is to measure the effect of a drug on some aspect of metabolism and requires well characterized radiotracers whose behavior in vivo can be related to a discrete biochemical transformation. A second approach is to study the labeled drug itself. This provides information on the drug's regional distribution and kinetics as well as its pharmacological profile and metabolism. Cocaine has been labeled in different positions with carbon-11 and with fluorine-18 and the stereoisomers of cocaine have also been labeled to characterize its binding and metabolism in human and baboon brain. Regional cocaine binding as measured by PET is consistent with reversible binding to striatal dopamine reuptake sites and its time course parallels the behavioral activation of cocaine. The behaviorally inactive enantiomer (+)-cocaine is rapidly metabolized in serum preventing its entry into the brain. These PET tracers are useful in understanding the neurochemical basis of cocaine's action

  17. National Biomedical Tracer Facility: Project definition study

    International Nuclear Information System (INIS)

    Heaton, R.; Peterson, E.; Smith, P.

    1995-01-01

    The Los Alamos National Laboratory is an ideal institution and New Mexico is an ideal location for siting the National Biomedical Tracer Facility (NBTF). The essence of the Los Alamos proposal is the development of two complementary irradiation facilities that combined with our existing radiochemical processing hot cell facilities and waste handling and disposal facilities provide a low cost alternative to other proposals that seek to satisfy the objectives of the NBTF. We propose the construction of a 30 MeV cyclotron facility at the site of the radiochemical facilities, and the construction of a 100 MeV target station at LAMPF to satisfy the requirements and objectives of the NBTF. We do not require any modifications to our existing radiochemical processing hot cell facilities or our waste treatment and disposal facilities to accomplish the objectives of the NBTF. The total capital cost for the facility defined by the project definition study is $15.2 M. This cost estimate includes $9.9 M for the cyclotron and associated facility, $2.0 M for the 100 MeV target station at LAMPF, and $3.3 M for design

  18. Isotope and chemical tracers in groundwater hydrology

    International Nuclear Information System (INIS)

    Kendall, C.; Stewart, M.K.; Morgenstern, U.; Trompetter, V.

    1999-01-01

    The course sessions cover: session 1, Fundamentals of stable and radioactive isotopes; session 2, Stable oxygen and hydrogen isotopes in hydrology: background, examples, sampling strategy; session 3, Catchment studies using oxygen and hydrogen isotopes: background - the hydrologic water balance, evapotranspiration - the lion's share, runoff generation - new water/old water fractions, groundwater recharge - the crumbs; session 4, Isotopes in catchment hydrology: survey of applications, future developments; session 5, Applications of tritium in hydrology: background and measurement, interpretation, examples; session 6, Case studies using mixing models: Hutt Valley groundwater system, an extended mixing model for simulating tracer transport in the unsaturated zone; session 7, Groundwater dating using CFC concentrations: background, sampling and measurement, use and applications; session 8, Groundwater dating with carbon-14: background, sampling and measurement, use and applications; session 9, NZ case studies: Tauranga warm springs, North Canterbury Plains groundwater; session 10, Stable carbon and nitrogen isotopes: background and examples, biological applications of C-N-S isotopes; session 11, New developments in isotope hydrology: gas isotopes, compound specific applications, age dating of sediments etc; session 12, NZ case studies: North Canterbury Plains groundwater (continued), Waimea Plains groundwater. (author). refs., figs

  19. National Biomedical Tracer Facility: Project definition study

    Energy Technology Data Exchange (ETDEWEB)

    Heaton, R.; Peterson, E. [Los Alamos National Lab., NM (United States); Smith, P. [Smith (P.A.) Concepts and Designs (United States)

    1995-05-31

    The Los Alamos National Laboratory is an ideal institution and New Mexico is an ideal location for siting the National Biomedical Tracer Facility (NBTF). The essence of the Los Alamos proposal is the development of two complementary irradiation facilities that combined with our existing radiochemical processing hot cell facilities and waste handling and disposal facilities provide a low cost alternative to other proposals that seek to satisfy the objectives of the NBTF. We propose the construction of a 30 MeV cyclotron facility at the site of the radiochemical facilities, and the construction of a 100 MeV target station at LAMPF to satisfy the requirements and objectives of the NBTF. We do not require any modifications to our existing radiochemical processing hot cell facilities or our waste treatment and disposal facilities to accomplish the objectives of the NBTF. The total capital cost for the facility defined by the project definition study is $15.2 M. This cost estimate includes $9.9 M for the cyclotron and associated facility, $2.0 M for the 100 MeV target station at LAMPF, and $3.3 M for design.

  20. Chemical and pharmacological aspects of cerebral tracers

    International Nuclear Information System (INIS)

    Rapin, J.R.; Duterte, D.; Le Poncin-Lafitte, M.; Coornaert, S.; Desplanches, G.; Bardy, A.; Askienazy, S.; Moretti, J.L.; Raynaud, C.

    1983-01-01

    Among the iodophenylalkylamines studied and labelled with iodine 125 or iodine 123, N-isopropyl-iodo-amphetamin (IAMP) was selected and proposed as tracer for blood flow, a ''chemical embolus'' having almost 100% extraction in the brain. A new way of obtaining N-isopropyl-p-iodo-amphetamin is proposed and the easily-applied exchange reaction with iodine 125 or 123 gives a product with a radiochemical purity of more than 96% and an unexchanged radioactive iodine content of less than 1%. The pharmacokinetic study of this product in the Wistar rat showed distribution in three compartments and the appearance of a steady state by the fourth minute. The target organes are the lungs, liver and brain. The latter receives 3% of the radioactivity and the autoradiographic study shows that the early distribution in the brain for IAMP closely equal the blood flow as found by a diffusible indicator. In the first hour, the redistribution is very low and at this time although IAMP is proposed for the study of regional blood flow, it does not exactly determine the flow but allows the cell activity [fr

  1. Chemical and pharmacological aspects of cerebral tracers

    International Nuclear Information System (INIS)

    Rapin, J.R.; Duterte, D.; Le Poncin-Lafitte, M.; Coornaert, S.; Desplanches, G.; Bardy, A.; Moretti, J.L.; Raynaud, C.

    1983-01-01

    Among the iodophenylalkylamines studied and labelled with iodine 125 or iodine 123, N-isopropyl-iodo-amphetamin (IAMP) was selected and proposed as tracer for blood flow, a ''chemical embolus'' having almost 100% extraction in the brain. A new way of obtaining N-isopropyl-p-iodo-amphetamin is proposed and the easily-applied exchange reaction with iodine 125 or 123 gives product with a radiochemical purity of more than 96% and an unexchanged radioactive iodine content of less than 1%. The pharmacokinetic study of this product in the Wistar rat showed distribution in three compartments and the appearance of a steady state by the fourth minute. The target organs are the lungs, liver and brain. The latter receives 3% of the radioactivity and the autoradiographic study shows that the early distribution in the brain for IAMP closely equals the blood flow as found by a diffusible indicator. In the first hour, the redistribution is very low and at this time although IAMP is proposed for the study of regional blood flow, it does not exactly determine the flow but rather mirrors cell activity [fr

  2. Groundwater–surface water interactions, vegetation dependencies and implications for water resources management in the semi-arid Hailiutu River catchment, China – a synthesis

    Directory of Open Access Journals (Sweden)

    Y. Zhou

    2013-07-01

    Full Text Available During the last decades, large-scale land use changes took place in the Hailiutu River catchment, a semi-arid area in northwest China. These changes had significant impacts on the water resources in the area. Insights into groundwater and surface water interactions and vegetation-water dependencies help to understand these impacts and formulate sustainable water resources management policies. In this study, groundwater and surface water interactions were identified using the baseflow index at the catchment scale, and hydraulic and water temperature methods as well as event hydrograph separation techniques at the sub-catchment scale. The results show that almost 90% of the river discharge consists of groundwater. Vegetation dependencies on groundwater were analysed from the relationship between the Normalized Difference Vegetation Index (NDVI and groundwater depth at the catchment scale and along an ecohydrogeological cross-section, and by measuring the sap flow of different plants, soil water contents and groundwater levels at different research sites. The results show that all vegetation types, i.e. trees (willow (Salix matsudana and poplar (Populus simonii, bushes (salix – Salix psammophila, and agricultural crops (maize – Zea mays, depend largely on groundwater as the source for transpiration. The comparative analysis indicates that maize crops use the largest amount of water, followed by poplar trees, salix bushes, and willow trees. For sustainable water use with the objective of satisfying the water demand for socio-economical development and to prevent desertification and ecological impacts on streams, more water-use-efficient crops such as sorghum, barley or millet should be promoted to reduce the consumptive water use. Willow trees should be used as wind-breaks in croplands and along roads, and drought-resistant and less water-use intensive plants (for instance native bushes should be used to vegetate sand dunes.

  3. A Systematic Method For Tracer Test Analysis: An Example Using Beowawe Tracer Data

    Energy Technology Data Exchange (ETDEWEB)

    G. Michael Shook

    2005-01-01

    Quantitative analysis of tracer data using moment analysis requires a strict adherence to a set of rules which include data normalization, correction for thermal decay, deconvolution, extrapolation, and integration. If done correctly, the method yields specific information on swept pore volume, flow geometry and fluid velocity, and an understanding of the nature of reservoir boundaries. All calculations required for the interpretation can be done in a spreadsheet. The steps required for moment analysis are reviewed in this paper. Data taken from the literature is used in an example calculation.

  4. Effect of ornithine on ammonia utilization and urea synthesis in isolated hepatocytes from fed rats

    International Nuclear Information System (INIS)

    Garwacki, S.; Wiechetek, M.; Souffrant, W.B.

    1988-01-01

    The effect of ornithine on the ammonia utilization and urea synthesis in hepatocytes isolated from fed male Wistar rats was investigated. On the basis of the 15 N tracer technique, it was found that ornithine stimulated urea synthesis with an increased utilization of the exogenously marked ammonia for urea, but deminished its utilization in other N-metabolic processes. The results also showed that the stimulation of urea synthesis due to ornithine resulted from the utilization of both exogenous and endogenous sources. (author)

  5. Our experience of blood flow measurements using radioactive tracers

    International Nuclear Information System (INIS)

    Danet, Bernard.

    1974-01-01

    A critical study of blood flow measuring methods is proposed. After a review of the various diffusible and non-diffusible radioactive tracers and the corresponding detector systems, the principles which allow to measure blood flow from the data so obtained, are studied. There is a different principle of flow measurement for each type of tracer. The theory of flow measurement using non-diffusible tracers (human serum albumin labelled with 131 I or sup(99m)Tc, 113 In-labelled siderophiline) and its application to cardiac flow measurement are described first. Then the theory of flow measurement using diffusible tracers ( 133 Xe, 85 Kr) and its application to measurement of blood flow through tissues (muscles and kidney particularly) are described. A personal experience of this various flow measurements is reported. The results obtained, the difficulties encountered and the improvments proposed are developed [fr

  6. Diffusing passive tracers in random incompressible flows: Statistical topography aspects

    International Nuclear Information System (INIS)

    Klyatskin, V.I.; Woyczynski, W.A.; Gurarie, D.

    1996-01-01

    The paper studies statistical characteristics of the passive tracer concentrations and of its spatial gradient, in random incompressible velocity fields from the viewpoint of statistical topography. The statistics of interest include mean values, probability distributions, as well as various functionals characterizing topographic features of tracers. The functional approach is used. We consider the influence of the mean flow (the linear shear flow) and the molecular diffusion coefficient on the statistics of the tracer. Most of our analysis is carried out in the framework of the delta-correlated (in time) approximation and conditions for its applicability are established. But we also consider the diffusion approximation scheme for finite correlation radius. The latter is applied to a diffusing passive tracer that undergoes sedimentation in a random velocity field

  7. Application of fluorescent-and radioactive tracers in Sedimentalogy

    International Nuclear Information System (INIS)

    Alencar, L.M.L. de.

    1981-01-01

    The development of techniques of sediment labelling, creating the possibility of using fluorescent and radioactive tracers not yet applied in Brazil, in the area of sedimentology, is studied. (A.R.H.) [pt

  8. Simulation of Tracer Transport in Porous Media: Application to Bentonites

    International Nuclear Information System (INIS)

    Bru, A.; Casero, D.

    2001-01-01

    We present a formal framework to describe tracer transport in heterogeneous media, such as porous media like bentonites. In these media, mean field approximation is not valid because there exist some geometrical constraints and the transport is anomalous. (Author)

  9. Chlorine isotopes potential as geo-chemical tracers

    Digital Repository Service at National Institute of Oceanography (India)

    Shirodkar, P.V.; Pradhan, U.K.; Banerjee, R.

    The potential of chlorine isotopes as tracers of geo-chemical processes of earth and the oceans is highlighted based on systematic studies carried out in understanding the chlorine isotope fractionation mechanism, its constancy in seawater and its...

  10. Hydraulic characterisation of karst systems with man-made tracers

    International Nuclear Information System (INIS)

    Werner, A.

    1998-01-01

    Tracer experiments using man-made tracers are common in hydrogeological exploration of groundwater aquifers in karst systems. In the present investigation, a convection-dispersion model (multidispersion model with consideration of several flow paths) and a single-cleft model (consideration of the diffusion between the cleft and the surrounding rock matrix) were used for evaluating tracer experiments in the main hydrological system of the saturated zone of karst systems. In addition to these extended analytical solutions, a numerical transport model was developed for investigating the influence of the transient flow rate on the flow and transport parameters. Comparative evaluations of the model approaches for the evaluation of tracer experiments were made in four different karst systems: Danube-Aach, Paderborn, Slowenia and Lurbach, of which the Danube-Aach system was considered as the most important. The investigation also comprised three supplementary experiments in order to enable a complete hydraulic characterisation of the system. (orig./SR) [de

  11. Systems approach to tracer data in groundwater hydrology

    International Nuclear Information System (INIS)

    Saxena, R.K.

    1977-01-01

    A brief review of current mathematical methods for the analysis of tracer data in groundwater hydrology has been given. The description of the hydrological cycle as a whole or in part, by a system (compartment) or sub-system under linear and stationary conditions is discussed. Basic concepts of transit time, residence time, their distributions in time and response characteristics of a system are outlined. From the knowledge of tracer input, output and systems response function for a generalised system, reservoir capacity and storage for given period can be estimated. Use of a time series model for environmental tracer data in discreet time scale aimed at the solution of hydrological problems e.g. mean transit time and reservoir capacity is also explored. It is concluded that the combination of tracer data with systems approach can go a long way in the study of some complex hydrological problems. (author)

  12. Results of repeat tracer tests at Ohaaki, NZ

    International Nuclear Information System (INIS)

    McCabe, W.J.; Morris, C.

    1995-01-01

    During 20 years of tracer testing at Ohaaki a number of wells have been used more than once as tracer injection sites. In studying the various responses obtained it has been necessary to consider variations in the experimental test conditions before making comparisons which relate to field conditions. Some very significant changes have occurred in the field hydrology in recent years and water flow speeds as high as those encountered at Wairakei have been demonstrated. (author). 4 refs., 2 tabs., 10 figs

  13. Evaporation rate in containers used for storing radioactive tracer solutions

    International Nuclear Information System (INIS)

    Gascon, J.L.

    2002-01-01

    In radiochemical analysis, the storage of a tracer solution is an important issue to bear in mind. The evaporation of the tracer solution depends on the type of container used for storing. Evaporation rate in four kinds of containers, i.e., flame-sealed glass ampoule, sealed glass flask, flame-sealed polyethylene ampoule and screw glass vial was studied. It is concluded that the evaporation rate depends on the system of closing. (author)

  14. Labeling of fruitflies and their identification by tracer activation

    International Nuclear Information System (INIS)

    Haisch, A.; Forster, S.; Staerk, H.

    1975-01-01

    A technique was worked out to label and identify cherry fruit flies (Rhagoletic cerasi L.) in large numbers. For that purpose, the tracers dysprosium and samarium were mingled with a carrier substance (silica gel) which, mixed with silica sand, formed the substrate for emergence. The flies, the pupae of which were in this substrate, took up with their ptilinum-labeled silica gel during their crawling through the sand up to the surface. The tracer was detected after its activation by neutron irradiation

  15. Use of tracers for locating and designing sea outfalls

    International Nuclear Information System (INIS)

    Gauthier, M.; Quetin, B.

    1976-01-01

    Various tracers are used for investigating the propagation of substances in solution or suspension (radioactive, biological, chemical substances and floats). Floats and dyes are the most employed. The main problems associated with the use of such tracers and data interpretation are discussed and it is shown how effective quantitative data can be obtained, especially as regards estimation of turbulent diffusion parameters and identification of suitable dispersion methods for purposes of determining pollutant concentration and areas affected thereby [fr

  16. Movement of iodine and rain water from the atmosphere to the plant - soil - water system by the activable tracer techniques

    International Nuclear Information System (INIS)

    Yuita, Kouichi

    1996-01-01

    Iodine is one of the important elements in the environmental and agricultural sciences. It is requested to elucidate the long-term behavior of iodine in the atmosphere - soil·plant - soil water system. We developed the new tracer method, in which iodine released into the atmosphere from the stack of iodine manufacturing plant in Chiba prefecture was used as the activable tracer. Using this method, we traced the direct deposition of iodine in atmosphere onto the plant tops and the penetration of fallout iodine into soil in an open air over a long period. A quantitative evaluation of recharge function of water resources in agricultural and forest lands of Japan was eagerly requested from the nation. For it, we developed the new Br - tracer method combined with the soil water sampling system with the alumina porous ceramic cup. This tracer method was successfully applied to the agricultural and forest land in the catchment area of Sakawa river in Kanagawa prefecture. And the infiltration rate of the rain water and irrigation water, from the soil surface to the dept of 3m of the soil horizon in the forest land, tea garden and paddy field was quantitatively measured during two years. (J.P.N.)

  17. Determination of the self purification of streams using tracers

    International Nuclear Information System (INIS)

    Salviano, J.S.

    1982-04-01

    A methodology for the 'in situ' evaluation of the self purification of streams is discussed. It consists of the simultaneous injection of two tracers into the stream. One of the tracers is oxidized by biochemical processes. It can be either artificially supplied to the stream or a naturally present component can be used. This tracer is used for the determination of the self purification parameters. The other tracer is conservative and allows for the hydrodynamic effects. Tests have been carried out in two streams with quite different hydrodynamic and physicochemical conditions. In the first stream, with a flow-rate of about 0.9 m 3 /s, urea was used as the nonconservative tracer. In the other stream, which had a flow-rate of about 5 m 3 /s, only a radioactive tracer has been used, and the rate of biochemical oxidation has been determined from BOD measurements. Calculations have been implemented on a digital computer. In both cases it was found that the reoxygenation rate is more conveniently determined by empirical formulas. Results from both tests have been deemed realistic by comparison with similar experiments. (Author) [pt

  18. Root zone effects on tracer migration in arid zones

    International Nuclear Information System (INIS)

    Tyler, S.W.; Walker, G.R.

    1994-01-01

    The study of groundwater recharge and soil water movement in arid regions has received increased attention in the search for safe disposal sites for hazardous wastes. In passing through the upper 1 to 2 m of most soil profiles, tracers indicative of recharge such as Cl, 2 H, 18 O, Br, 3 H, and 56 Cl are subjected to a wide range of processes not encountered deeper in the profile. This transition zone, where water enters as precipitation and leaves as recharge, is often ignored when environmental tracers are used to estimate deep soil water flux and recharge, yet its effect may be profound. In this work, we reexamine the processes of root extraction and its effect on the velocity and distribution of tracers. Examples are presented for idealized conditions, which show clearly the relation between the root zone processes and the deep drainage or recharge. The results indicate that, when recharge is small and root zone processes are not accounted for, tracer techniques can significantly overestimate recharge until the tracer has moved well below the root zone. By incorporating simple models of root zone processes, a clearer understanding of tracer distributions and a more accurate estimate of recharge can then be made. 11 refs., 9 figs

  19. Quantifying solute transport processes: are chemically "conservative" tracers electrically conservative?

    Science.gov (United States)

    Singha, Kamini; Li, Li; Day-Lewis, Frederick D.; Regberg, Aaron B.

    2012-01-01

    The concept of a nonreactive or conservative tracer, commonly invoked in investigations of solute transport, requires additional study in the context of electrical geophysical monitoring. Tracers that are commonly considered conservative may undergo reactive processes, such as ion exchange, thus changing the aqueous composition of the system. As a result, the measured electrical conductivity may reflect not only solute transport but also reactive processes. We have evaluated the impacts of ion exchange reactions, rate-limited mass transfer, and surface conduction on quantifying tracer mass, mean arrival time, and temporal variance in laboratory-scale column experiments. Numerical examples showed that (1) ion exchange can lead to resistivity-estimated tracer mass, velocity, and dispersivity that may be inaccurate; (2) mass transfer leads to an overestimate in the mobile tracer mass and an underestimate in velocity when using electrical methods; and (3) surface conductance does not notably affect estimated moments when high-concentration tracers are used, although this phenomenon may be important at low concentrations or in sediments with high and/or spatially variable cation-exchange capacity. In all cases, colocated groundwater concentration measurements are of high importance for interpreting geophysical data with respect to the controlling transport processes of interest.

  20. Tracer verification and monitoring of containment systems (II)

    International Nuclear Information System (INIS)

    Williams, C.V.; Dunn, S.D.; Lowry, W.E.

    1997-01-01

    A tracer verification and monitoring system, SEAtrace trademark, has been designed and field tested which uses gas tracers to evaluate, verify, and monitor the integrity of subsurface barriers. This is accomplished using an automatic, rugged, autonomous monitoring system combined with an inverse optimization code. A gaseous tracer is injected inside the barrier and an array of wells outside the barrier are monitored. When the tracer gas is detected, a global optimization code is used to calculate the leak parameters, including leak size, location, and when the leak began. The multipoint monitoring system operates in real-time, can be used to measure both the tracer gas and soil vapor contaminants, and is capable of unattended operation for long periods of time (months). The global optimization code searches multi-dimensional open-quotes spaceclose quotes to find the best fit for all of the input parameters. These parameters include tracer gas concentration histories from multiple monitoring points, medium properties, barrier location, and the source concentration. SEAtrace trademark does not attempt to model all of the nuances associated with multi-phase, multi-component flow, but rather, the inverse code uses a simplistic forward model which can provide results which are reasonably accurate. The system has calculated leak locations to within 0.5 meters and leak radii to within 0.12 meters

  1. Copper ion as a new leakage tracer.

    Science.gov (United States)

    Modaresi, J; Baharizade, M; Shareghi, A; Ahmadi, M; Daneshkazemi, A

    2013-12-01

    Most failures of root canal treatments are caused by bacteria. Studies showed that the most common cause of endodontic failures were the incomplete obturation of the root canal and the lack of adequate apical seal. Some in-vitro methods are used to estimate sealing quality, generally by measuring microleakage that allows the tracer agent to penetrate the filled canal. Conventional methods of evaluating the seal of endodontically treated teeth are complicated and have some drawbacks. We used copper ion diffusion method to assess the leakage and the results were compared to dye penetration method. The crowns of 21 extracted teeth were cut off at the CEJ level. After preparing the canals, the teeth were placed in tubes containing saline. They were divided randomly into 15 experimental cases; 3 positive and 3 negative controls. Positive controls were filled by single cone without sealer while the experimental and the negative control groups were filled by lateral technique. The coronal portion of gutta was removed and 9mm was left. The external surface of each tooth was coated with nail polish. Two millimeters of apical portion was immersed into 9ml of distilled water and 0.3ml of CuSO4 solution was injected into the coronal portion. After 2 days, copper sulfate was measured by an atomic absorption spectrophotometer. The teeth were then immersed in 2% methylene blue for 24 hours, sectioned and the extent of dye penetration was measured by a stereomicroscope. The maximum and minimum recorded copper ion concentrations for the experimental group were 18.37 and 2.87ppm respectively. The maximum and minimum recorded dye penetrations for the experimental group were 8.5 and 3.5mm respectively. The statistical analysis, adopting paired samples test, showed poor correlation between average recorded results of two methods. Based on our results, there was no significant correlation between the dye penetration and the copper ion diffusion methods.

  2. Tracer verification and monitoring of containment systems

    International Nuclear Information System (INIS)

    Lowry, W.; Dunn, S.D.; Williams, C.

    1996-01-01

    In-situ barrier emplacement techniques and materials for the containment of high-risk contaminants in soils are currently being developed by the Department of Energy (DOE). Because of their relatively high cost, the barriers are intended to be used in cases where the risk is too great to remove the contaminants, the contaminants are too difficult to remove with current technologies, or the potential for movement of the contaminants to the water table is so high that immediate action needs to be taken to reduce health risks. Consequently, barriers are primarily intended for use in high-risk sites where few viable alternatives exist to stop the movement of contaminants in the near term. Assessing the integrity of the barrier once it is emplaced, and during its anticipated life, is a very difficult but necessary requirement. Existing surface-based and borehole geophysical techniques do not provide the degree of resolution required to assure the formation of an integral in-situ barrier. Science and Engineering Associates, Inc., (SEA) and Sandia National Laboratories (SNL) are developing a quantitative subsurface barrier assessment system using gaseous tracers. Called SEAtrace trademark, this system integrates an autonomous, multipoint soil vapor sampling and analysis system with a global optimization modeling methodology to pinpoint leak sources and sizes in real time. SEAtrace trademark is applicable to impermeable barrier emplacements above the water table, providing a conservative assessment of barrier integrity after emplacement, as well as a long term integrity monitoring function. The SEAtrace trademark system is being developed under funding by the DOE-EM Subsurface Contaminant Focus Area

  3. Biogeochemical tracers of the marine cyanobacterium Trichodesmium

    Science.gov (United States)

    Carpenter, Edward J.; Harvey, H. Rodger; Fry, Brian; Capone, Douglas G.

    1997-01-01

    We examined the utility of several biogeochemical tracers for following the fate of the planktonic diazotrophic cyanobacterium Trichodesmium in the sea. The presence of a (CIO) fatty acid previously reported was observed in a culture of Trichodesmium but was not found in natural samples. This cyanobacterium had high concentrations of C 14 and C 16 acids, with lesser amounts of several saturated and unsaturated C 18 fatty acids. This composition was similar to that of other marine cyanobacteria. The major hydrocarbon identified was the C 17n-alkane, which was present in all samples from the five stations examined. Sterols common to algae and copepods were observed in many samples along with hopanoids representative of bacteria, suggesting a varied community structure in colonies collected from different stations. We found no unique taxonomic marker of Trichodesmium among the sterols. Measurements of the σ 15N and σ 13C in Trichodesmium samples from the SW Sargasso and NW Caribbean Seas averaged -0.4960 (range from -0.7 to -0.25960) and -12.9%0 (range from -15.2 to -11.9960), respectively, thus confirming previous observations that this cyanobacterial diazotroph has both the lowest σ 15N and highest σ 13C of any marine phytoplankter observed to date. A culture of Trichodesmium grown under diazotrophic conditions had a σ 15N between -1.3 and -3.6960. Our results support the supposition that the relatively low σ 15N and high σ 13C values observed in suspended and sediment-trapped material from some tropical and subtropical seas result from substantial input of C and N by Trichodesmium.

  4. Marine chemistry and tracer applications of radiocaesium

    International Nuclear Information System (INIS)

    McKay, W.A.

    1983-03-01

    The general aims of this project were to study the marine chemistry of Windscale-derived radiocaesium and to continue previous research at Glasgow University on its tracer application in Scottish waters and sediments. It was found that a considerable percentage of sediment-associated 137 Cs (approximately 12 to 50%) may be contained by carbonate, oxide and organic coatings which appear to be relatively stable under a wide range of redox conditions. Whilst the partitioning of 137 Cs is related to the concentration of these oxides, organics and, to a much lesser extent, carbonates, their function is predominantly to prevent 137 Cs release from clay mineral exchange sites. 137 Cs activities per unit sediment weight were highest in the clay fraction with its uptake by coarse sediments appearing to be controlled by clay minerals coatings formed in the marine environment and cemented partly by oxides and organics. Though the sites sampled (Clyde Sea Area (C.S.A.) and L. Etive) encompassed a wide range of sediment types, the range of estimated 137 Cs distribution coefficients (K D ) was relatively small (360 to 890). Coatings may thus have more influence on K d s in the coastal marine environment than particle size distributions. Apparent concentration factors (C F s) of X325, X2800 and X1910 were determined for the associated carbonate, oxide and organic coatings, for a site off Greenock. Use of 'dry' sediments appeared to produce considerably overestimated values for the degree of 137 Cs fixation. Thus 'wet' sediments were used in these studies. Over the 1978-1981 period, approximately 35% of Windscale output passed through the C.S.A., diluted 26 times during transit. An estimated 0.3% of this water-borne inventory was removed into the sediments. Windscale to C.S.A. transit and residence times of 4 and 12 months respectively were derived. Monitoring the deeper levels of L. Etive allowed 137 Cs to be used to trace patterns of w

  5. Stable isotopes as tracers for radionuclides

    International Nuclear Information System (INIS)

    Giussani, A.; Bartolo, D. de; Cantone, M.C.; Zilker, T.; Greim, H.; Roth, P.; Werner, E.

    2000-01-01

    The assessment of internal dose after incorporation of radionuclides requires as input data the knowledge of the uptake into the systemic circulation, the distribution and retention in selected organs, the excretion pathways. Realistic biokinetic models are needed for reliable estimates, correct interpretation of bioassay measurements, appropriate decision-making in radiological emergencies. For many radionuclides, however, the biokinetic models currently recommended are often generic, with very few specific parameters, due to the lack of experimental human data. The use of stable isotopes as tracers enables to determine important biokinetic parameters such as the fractional uptake, the clearance from the transfer compartment, the excretion patterns under experimentally controlled conditions. The subjects investigated are not exposed to any radiation risk, so this technique enables to obtain biokinetic information also for sensitive groups of the population, such as children or pregnant women, and to determine age- and gender-specific model parameters. Sophisticated analytical method, able to discriminate and quantitate different isotopes of the same element in complex matrices such as biological fluids, have to be purposely developed and optimized. Activation analysis and mass spectrometry are the most proper techniques of choice. Experiments were conducted with molybdenum, tellurium, ruthenium and zirconium. Activation analysis with protons, thermal ionization mass spectrometry and inductively coupled mass spectrometry were employed for the determination of stable isotopes of these elements in blood plasma and urine samples. Several deviations from the predictions of the ICRP models were observed. For example, modifications to the current model for molybdenum have been suggested on the basis of these results. The dose coefficients to the target regions calculated with this proposed model are even of one order of magnitude different than the ICRP estimates

  6. Sistem Pre Kompilasi Data Tracer Studi Online Ditjen Belmawa Ristekdikti (Studi Kasus: Politeknik Harapan Bersama

    Directory of Open Access Journals (Sweden)

    Very Kurnia Bakti

    2017-01-01

    Full Text Available Tracer studi merupakan salah satu upaya yang diharapkan dapat menyediakan informasi untuk mengevaluasi hasil pendidikan di Politeknik Harapan Bersama dari kuisioner yang diberikan kepada alumni. Kegiatan tracer studi ini sudah dilaksanakan secara online, namun masih terdapat kendala pada bagian sistem yang digunakan saat ini, hal tersebut menyebabkan Politeknik Harapan Bersama tidak dapat melaporkan / mengunggah hasil tracer studi kepada Ditjen Belmawa Ristekdikti, dimana form kuisioner dan data export tracer studi yang dihasilkan berbeda dengan kebutuhan seperti yang tercantum pada surat edaran No. 313/B/SE/2016 tentang pelaksanaan tracer studi di tingkat perguruan tinggi. Mengingat pentingnya tracer studi sebagai umpan balik bagi Politeknik Harapan Bersama, maka perlu solusi untuk mengatasi kekurangan sistem ini. Dengan merubah sistem yang ada dengan sistem tracer studi yang baru merupakan solusi yang tepat dalam permasalahan ini. Sistem tracer studi yang baru mampu menghasilkan data tracer studi alumni dan pengisian form kuisioner sesuai dengan standar Ditjen Belmawa Ristekdikti yang dapat diunggah sistem tracer studi ristekdikti.

  7. Field measurements of tracer gas transport by barometric pumping

    International Nuclear Information System (INIS)

    Lagus, P.L.; McKinnis, W.B.; Hearst, J.R.; Burkhard, N.R.; Smith, C.F.

    1994-01-01

    Vertical gas motions induced by barometric pressure variations can carry radioactive gases out of the rubblized region produced by an underground nuclear explosion, through overburden rock, into the atmosphere. To better quantify transit time and amount of transport, field experiments were conducted at two sites on Pahute Mesa, Kapelli and Tierra, where radioactive gases had been earlier detected in surface cracks. At each site, two tracer gases were injected into the rubblized chimney 300-400 m beneath the surface and their arrival was monitored by concentration measurements in gas samples extracted from shallow collection holes. The first ''active'' tracer was driven by a large quantity of injected air; the second ''passive'' tracer was introduced with minimal gas drive to observe the natural transport by barometric pumping. Kapelli was injected in the fall of 1990, followed by Tierra in the fall of 1991. Data was collected at both sites through the summer of 1993. At both sites, no surface arrival of tracer was observed during the active phase of the experiment despite the injection of several million cubic feet of air, suggesting that cavity pressurization is likely to induce horizontal transport along high permeability layers rather than vertical transport to the surface. In contrast, the vertical pressure gradients associated with barometric pumping brought both tracers to the surface in comparable concentrations within three months at Kapelli, whereas 15 months elapsed before surface arrival at Tierra. At Kapelli, a quasisteady pumping regime was established, with tracer concentrations in effluent gases 1000 times smaller than concentrations thought to exist in the chimney. Tracer concentrations observed at Tierra were typically an order of magnitude smaller. Comparisons with theoretical calculations suggest that the gases are traveling through ∼1 millimeter vertical fractures spaced 2 to 4 meters apart. 6 refs., 18 figs., 3 tabs

  8. Characterization of a managed aquifer recharge system using multiple tracers.

    Science.gov (United States)

    Moeck, Christian; Radny, Dirk; Popp, Andrea; Brennwald, Matthias; Stoll, Sebastian; Auckenthaler, Adrian; Berg, Michael; Schirmer, Mario

    2017-12-31

    Knowledge about the residence times of artificially infiltrated water into an aquifer and the resulting flow paths is essential to developing groundwater-management schemes. To obtain this knowledge, a variety of tracers can be used to study residence times and gain information about subsurface processes. Although a variety of tracers exists, their interpretation can differ considerably due to subsurface heterogeneity, underlying assumptions, and sampling and analysis limitations. The current study systematically assesses information gained from seven different tracers during a pumping experiment at a site where drinking water is extracted from an aquifer close to contaminated areas and where groundwater is artificially recharged by infiltrating surface water. We demonstrate that the groundwater residence times estimated using dye and heat tracers are comparable when the thermal retardation for the heat tracer is considered. Furthermore, major ions, acesulfame, and stable isotopes (δ 2 H and δ 18 O) show that mixing of infiltrated water and groundwater coming from the regional flow path occurred and a vertical stratification of the flow system exist. Based on the concentration patterns of dissolved gases (He, Ar, Kr, N 2 , and O 2 ) and chlorinated solvents (e.g., tetrachloroethene), three temporal phases are observed in the ratio between infiltrated water and regional groundwater during the pumping experiment. Variability in this ratio is significantly related to changes in the pumping and infiltration rates. During constant pumping rates, more infiltrated water was extracted, which led to a higher dilution of the regional groundwater. An infiltration interruption caused however, the ratio to change and more regional groundwater is extracted, which led to an increase in all concentrations. The obtained results are discussed for each tracer considered and its strengths and limitations are illustrated. Overall, it is demonstrated that aquifer heterogeneity and

  9. Assessing preferential flow by simultaneously injecting nanoparticle and chemical tracers

    KAUST Repository

    Subramanian, S. K.; Li, Yan; Cathles, L. M.

    2013-01-01

    The exact manner in which preferential (e.g., much faster than average) flow occurs in the subsurface through small fractures or permeable connected pathways of other kinds is important to many processes but is difficult to determine, because most chemical tracers diffuse quickly enough from small flow channels that they appear to move more uniformly through the rock than they actually do. We show how preferential flow can be assessed by injecting 2 to 5 nm carbon particles (C-Dots) and an inert KBr chemical tracer at different flow rates into a permeable core channel that is surrounded by a less permeable matrix in laboratory apparatus of three different designs. When the KBr tracer has a long enough transit through the system to diffuse into the matrix, but the C-Dot tracer does not, the C-Dot tracer arrives first and the KBr tracer later, and the separation measures the degree of preferential flow. Tracer sequestration in the matrix can be estimated with a Peclet number, and this is useful for experiment design. A model is used to determine the best fitting core and matrix dispersion parameters and refine estimates of the core and matrix porosities. Almost the same parameter values explain all experiments. The methods demonstrated in the laboratory can be applied to field tests. If nanoparticles can be designed that do not stick while flowing through the subsurface, the methods presented here could be used to determine the degree of fracture control in natural environments, and this capability would have very wide ranging value and applicability.

  10. Stable isotope tracers and exercise physiology: past, present and future.

    Science.gov (United States)

    Wilkinson, Daniel J; Brook, Matthew S; Smith, Kenneth; Atherton, Philip J

    2017-05-01

    Stable isotope tracers have been invaluable assets in physiological research for over 80 years. The application of substrate-specific stable isotope tracers has permitted exquisite insight into amino acid, fatty-acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxidation, in a tissue-specific and whole-body fashion) in health, disease and response to acute and chronic exercise. Yet, despite many breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit physiological insight, e.g. the need for intravenous infusions and restriction to short-term studies (hours) in controlled laboratory settings. In recent years significant interest has developed in alternative stable isotope tracer techniques that overcome these limitations, in particular deuterium oxide (D 2 O or heavy water). The unique properties of this tracer mean that through oral administration, the turnover and flux through a number of different substrates (muscle proteins, lipids, glucose, DNA (satellite cells)) can be monitored simultaneously and flexibly (hours/weeks/months) without the need for restrictive experimental control. This makes it uniquely suited for the study of 'real world' human exercise physiology (amongst many other applications). Moreover, using D 2 O permits evaluation of turnover of plasma and muscle proteins (e.g. dynamic proteomics) in addition to metabolomics (e.g. fluxomics) to seek molecular underpinnings, e.g. of exercise adaptation. Here, we provide insight into the role of stable isotope tracers, from substrate-specific to novel D 2 O approaches, in facilitating our understanding of metabolism. Further novel potential applications of stable isotope tracers are also discussed in the context of integration with the snowballing field of 'omic' technologies. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

  11. Evaluating 10B-enriched Boric Acid, Bromide, and Heat as Tracers of Recycled Groundwater Flow near MAR Operations

    Science.gov (United States)

    Becker, T.; Clark, J. F.

    2012-12-01

    Coupled with the unpredictability of a changing climate, the projected growth in human population over the next century requires new and innovative ways to augment already-depleted water supplies. An increasingly popular and promising development is managed aquifer recharge (MAR), a cost-effective method of intentionally storing potable water in groundwater aquifers at engineered sites worldwide. Reclaimed (or recycled) water, defined as cleaned and treated wastewater, will account for a larger portion of MAR water in future years. A crucial component for managing groundwater recharged with reclaimed water is its subsurface travel time. The California Department of Public Health (CDPH), with the most recent draft of regulations issued on November 21, 2011, requires the application of groundwater tracers to demonstrate subsurface residence time. Residence time increases the quality of reclaimed water via soil-aquifer treatment (SAT), which includes mechanisms such as sorption, biological degradation, and microbial inactivation to remove potential contaminants or pathogens. This study addresses the need for an appropriate tracer to determine groundwater residence times near MAR facilities. Standard shallow groundwater dating techniques, such as T/3He and chlorofluorocarbon (CFC) methods, cannot be used because their uncertainties are typically ± 2 years, longer than the target CDPH retention time of ~6 months. These methods also cannot map preferential flow paths. Sulfur hexafluoride (SF6), a nonreactive synthetic gas, is well-established as a deliberate tracer for determining subsurface travel time; however, SF6 is a very strong greenhouse gas and the California Air Resources Board (CARB) is regulating its emission. Other tracers, such as noble gas isotopes, that have successfully determined subsurface retention times are impractical due to their high cost. A multi-tracer experiment at the San Gabriel Spreading Grounds test basin (Montebello Forebay, Los Angeles

  12. Integrated Synthesis of the Permian Basin: Data and Models for Recovering Existing and Undiscovered Oil Resources from the Largest Oil-Bearing Basin in the U.S.

    Energy Technology Data Exchange (ETDEWEB)

    John Jackson; Katherine Jackson

    2008-09-30

    Large volumes of oil and gas remain in the mature basins of North America. This is nowhere more true than in the Permian Basin of Texas and New Mexico. A critical barrier to recovery of this vast remaining resource, however, is information. Access to accurate geological data and analyses of the controls of hydrocarbon distribution is the key to the knowledge base as well as the incentives needed by oil and gas companies. The goals of this project were to collect, analyze, synthesize, and deliver to industry and the public fundamental information and data on the geology of oil and gas systems in the Permian Basin. This was accomplished in two ways. First we gathered all available data, organized it, and placed it on the web for ready access. Data include core analysis data, lists of pertinent published reports, lists of available cores, type logs, and selected PowerPoint presentations. We also created interpretive data such as type logs, geological cross sections, and geological maps and placed them in a geospatially-registered framework in ARC/GIS. Second, we created new written syntheses of selected reservoir plays in the Permian basin. Although only 8 plays were targeted for detailed analysis in the project proposal to DOE, 14 were completed. These include Ellenburger, Simpson, Montoya, Fusselman, Wristen, Thirtyone, Mississippian, Morrow, Atoka, Strawn, Canyon/Cisco, Wolfcamp, Artesia Group, and Delaware Mountain Group. These fully illustrated reports include critical summaries of published literature integrated with new unpublished research conducted during the project. As such these reports provide the most up-to-date analysis of the geological controls on reservoir development available. All reports are available for download on the project website and are also included in this final report. As stated in our proposal, technology transfer is perhaps the most important component of the project. In addition to providing direct access to data and reports through

  13. TracerLPM (Version 1): An Excel® workbook for interpreting groundwater age distributions from environmental tracer data

    Science.gov (United States)

    Jurgens, Bryant C.; Böhlke, J.K.; Eberts, Sandra M.

    2012-01-01

    TracerLPM is an interactive Excel® (2007 or later) workbook program for evaluating groundwater age distributions from environmental tracer data by using lumped parameter models (LPMs). Lumped parameter models are mathematical models of transport based on simplified aquifer geometry and flow configurations that account for effects of hydrodynamic dispersion or mixing within the aquifer, well bore, or discharge area. Five primary LPMs are included in the workbook: piston-flow model (PFM), exponential mixing model (EMM), exponential piston-flow model (EPM), partial exponential model (PEM), and dispersion model (DM). Binary mixing models (BMM) can be created by combining primary LPMs in various combinations. Travel time through the unsaturated zone can be included as an additional parameter. TracerLPM also allows users to enter age distributions determined from other methods, such as particle tracking results from numerical groundwater-flow models or from other LPMs not included in this program. Tracers of both young groundwater (anthropogenic atmospheric gases and isotopic substances indicating post-1940s recharge) and much older groundwater (carbon-14 and helium-4) can be interpreted simultaneously so that estimates of the groundwater age distribution for samples with a wide range of ages can be constrained. TracerLPM is organized to permit a comprehensive interpretive approach consisting of hydrogeologic conceptualization, visual examination of data and models, and best-fit parameter estimation. Groundwater age distributions can be evaluated by comparing measured and modeled tracer concentrations in two ways: (1) multiple tracers analyzed simultaneously can be evaluated against each other for concordance with modeled concentrations (tracer-tracer application) or (2) tracer time-series data can be evaluated for concordance with modeled trends (tracer-time application). Groundwater-age estimates can also be obtained for samples with a single tracer measurement at one

  14. Analysis of infiltration through mill tailings using a bromide tracer

    International Nuclear Information System (INIS)

    Lewis, G.J.; Stephens, D.B.

    1985-01-01

    Infiltration of precipitation into tailings impoundments as a means of recharge to underlying materials is often considered insignificant, particularly in arid and semi-arid environments. A series of experiments was performed to investigate the behavior of infiltrated precipitation into tailing soils, by the use of a bromide tracer. A bromide tracer was applied to the surface of columns driven into the tailings to monitor downward advancement of tracer-laden water. Controlled laboratory experiments on the behavior of the bromide tracer under varying precipitation events and initial soil moisture contents were also conducted. Results indicate that a definite downward migration of infiltrated precipitation occurs, particularly with large magnitude precipitation events, and that, eventually, some fraction of the infiltrated precipitation may continue downward below the zone affected by evaporation. The use of an artificially applied bromide tracer to monitor depth of infiltration of precipitation is a simple, safe technique that can provide valuable information for long-term tailings management strategies at low cost

  15. Development of radioisotope tracer technology and nucleonic control system

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Joon Ha; Lee, Myun Joo; Jung, Sung Hee and others

    1999-04-01

    The purpose of this study is to develop the radioisotope tracer technology, which can be used in solving industrial and environmental problems and basic technology of nuclear control systems that are widely used for automation of industrial plants, and to build a strong tracer group to support the local industries. In relation to the tracer technology, the data acquisition system, the column scanning equipment and the detection pig for a leakage test have been developed. In order to use in analyzing data of tracer experiments, a computer program for the analysis of residence time distribution has been created as well. These results were utilized in developing the tracer technologies, such as the column scanning, the flow measurement using the dilution method, the simultaneous monitoring rotational movement of piston rings and the optimization of a waste water treatment facility, and the technologies were successfully demonstrated in the local industrial. The stripper of RFCC reactor has been examined to find an unwanted structure in it by imminent request from the industry. Related to the development of nucleonic control system, the state of art report on the technology has been written and an equipment for the analysis of asphalt content has been developed. (author)

  16. Spectral analysis for evaluation of myocardial tracers for medical imaging

    International Nuclear Information System (INIS)

    Huesman, Ronald H.; Reutter, Bryan W.; Marshall, Robert C.

    2000-01-01

    Kinetic analysis of dynamic tracer data is performed with the goal of evaluating myocardial radiotracers for cardiac nuclear medicine imaging. Data from experiments utilizing the isolated rabbit heart model are acquired by sampling the venous blood after introduction of a tracer of interest and a reference tracer. We have taken the approach that the kinetics are properly characterized by an impulse response function which describes the difference between the reference molecule (which does not leave the vasculature) and the molecule of interest which is transported across the capillary boundary and is made available to the cell. Using this formalism we can model the appearance of the tracer of interest in the venous output of the heart as a convolution of the appearance of the reference tracer with the impulse response. In this work we parameterize the impulse response function as the sum of a large number of exponential functions whose predetermined decay constants form a spectrum, and each is required only to have a nonnegative coefficient. This approach, called spectral analysis, has the advantage that it allows conventional compartmental analysis without prior knowledge of the number of compartments which the physiology may require or which the data will support

  17. Analysis of some laboratory tracer runs in natural fissures

    International Nuclear Information System (INIS)

    Moreno, L.; Neretnieks, I.

    1984-01-01

    Tracer tests in natural fissures performed in the laboratory are analysed by means of fitting two different models. In the experiments, sorbing and non-sorbing tracers were injected into a natural fissure running parallel to the axis of a drill core. The models take into account advection, diffusion into the rock matrix, sorption onto the rock surface and dispersion. For the last mechanism, one of the models considers hydrodynamic dispersion while the other model assumes channeling dispersion. The models take into account time delays in the inlet and outlet channels. The dispersion characteristics and water residence time were determined from the experiments with non-sorbing tracers. Surface and volume sorption coefficients and data on diffusion into the rock matrix were determined for the sorbing tracers. The results are compared with values independently determined in the laboratory. Good agreement was obtained using either model. When these models are used for prediction of tracer transport over larger distances, the results will depend on the model. The model with channeling dispersion will show a greater dispersion than the model with hydrodynamic dispersion. (author)

  18. Renewable Resources, Capital Accumulation, and Economic Growth

    OpenAIRE

    Wei-Bin Zhang

    2011-01-01

    This paper proposes a dynamic economic model with physical capital and renewable resources. Different from most of the neoclassical growth models with renewable resources which are based on microeconomic foundation and neglect physical capital accumulation, this study proposes a growth model with dynamics of renewable resources and physical capital accumulation. The model is a synthesis of the neoclassical growth theory and the traditional dynamic models of renewable resources with an alterna...

  19. You are not always what we think you eat. Selective assimilation across multiple whole-stream isotopic tracer studies

    International Nuclear Information System (INIS)

    Dodds, W. K.; Collins, S. M.; Hamilton, S. K.; Johnson, S.; Webster, J. R.; Simon, K. S.; Whiles, M. R.; Rantala, H. M.; McDowell, W. H.; Peterson, S. D.; Riis, T.; Crenshaw, C. L.; Thomas, S. A.; Kristensen, P. B.; Cheever, B. M.; Flecker, A. S.; Griffiths, N. A.; Crowl, T.; Rosi-Marshall, E. J.; El-Sabaawi, R.; Marti, E.

    2014-01-01

    Analyses of 21 15 N stable isotope tracer experiments, designed to examine food web dynamics in streams around the world, indicated that the isotopic composition of food resources assimilated by primary consumers (mostly invertebrates) poorly reflected the presumed food sources. Modeling indicated that consumers assimilated only 33-50% of the N available in sampled food sources such as decomposing leaves, epilithon, and fine particulate detritus over feeding periods of weeks or more. Thus, common methods of sampling food sources consumed by animals in streams do not sufficiently reflect the pool of N they assimilate. Lastly, Isotope tracer studies, combined with modeling and food separation techniques, can improve estimation of N pools in food sources that are assimilated by consumers

  20. Test plan for determining breathing rates in single shell tanks using tracer gases. Revision 1

    International Nuclear Information System (INIS)

    Andersen, J.A.

    1997-01-01

    This test plan specifies the requirements and conditions for the injection of tracer gas (Helium (He)) into single shell tanks to determine breathing rates using periodic sampling. The eight tanks which have been selected at the time this Test Plan was developed are A-101, AX-102, AX-103, BY-105, C-107, U-103 (U-103 is counted twice, once during the winter months and once during the summer), and U-105. Other tanks to be sampled will be assigned by Pacific Northwest National Laboratory (PNNL) at a later date in the study process as resources allow, the document shall be revised as required. The sampling of headspace for each of these tanks shall be performed using available risers or the Standard Hydrogen Monitoring System (SHMS) cabinet as available. The tank farm vapor cognizant engineer shall assign the injection and sample testing point for each tank and document the point in the field work package. SUMMA TMI canisters, equipped in-line with dual particulate air filters and two silica gel sorbent traps will be used to collect the gas samples. The purpose of dual particulate air filters is to ensure no radioactive particulates are transferred to the SUMMA TMI canisters. The silica gel sorbent traps will effectively eliminate any tritiated water vapor that may be present in the sample gas stream. PNNL shall supply the tracer gases injection system and shall perform the analysis on the headspace samples. TWRS Characterization project shall inject the tracer gas and perform the sampling. Refer to Engineering Task Plan HNF-SD-TWR-ETP-002 for a detailed description of the responsibilities for this task

  1. Tracer travel time and model validation

    International Nuclear Information System (INIS)

    Tsang, Chin-Fu.

    1988-01-01

    The performance assessment of a nuclear waste repository demands much more in comparison to the safety evaluation of any civil constructions such as dams, or the resource evaluation of a petroleum or geothermal reservoir. It involves the estimation of low probability (low concentration) of radionuclide transport extrapolated 1000's of years into the future. Thus models used to make these estimates need to be carefully validated. A number of recent efforts have been devoted to the study of this problem. Some general comments on model validation were given by Tsang. The present paper discusses some issues of validation in regards to radionuclide transport. 5 refs

  2. Natural stream flow-rates measurements by tracer techniques

    International Nuclear Information System (INIS)

    Cuellar Mansilla, J.

    1982-01-01

    This paper presents the study of the precision obtained measuring the natural stream flow rates by tracer techniques, especially when the system presents a great slope and a bed constituted by large and extended particle size. The experiences were realized in laboratory pilot channels with flow-rates between 15 and 130 [1/s]; and in natural streams with flow-rates from 1 to 25 m 3 /s. Tracer used were In-133m and Br-82 for laboratory and field measurements respectively. In both cases the tracer was injected as a pulse and its dilution measured collecting samples in the measured section, at constant flow-rates, of 5[1] in laboratory experiences and 60[1] of water in field experiences. Precisions obtained at a 95% confidence level were about 2% for laboratory and 3% for field. (I.V.)

  3. Collective and tracer diffusion kinetics in the ternary random alloy

    International Nuclear Information System (INIS)

    Belova, I.V.; Murch, G.E.; Allnatt, A.R.

    2002-01-01

    In this study, collective and tracer diffusion kinetics is addressed for the ternary random alloy. A formal solution from the self-consistent theory of Moleko et al (Moleko L K, Allnatt A R and Allnatt E L 1989 Phil. Mag. A 59 141) is derived for collective diffusion and compared with the corresponding solution for the binary random alloy. Tracer diffusion in the ternary alloy is treated from the perspective of a special case of the quaternary random alloy. Results from Monte Carlo calculations for tracer and collective correlation factors (for the bcc ternary random alloy) are found to be in excellent agreement with this self-consistent theory but in only semi-quantitative agreement with the earlier theory of Manning (Manning J R 1971 Phys. Rev. B 4 1111). (author)

  4. Concentration dynamics in lakes and reservoirs. Studies using radioactive tracers

    International Nuclear Information System (INIS)

    Gilath, Ch.

    1983-01-01

    The use of radioactive tracers for the investigation of concentration dynamics of inert soluble matter in lakes and reservoirs is reviewed. Shallow and deep stratified lakes are considered. The mechanism of mixing in lakes, flow pattern and input - output response are discussed. The methodology of the use of radioactive tracers for concentration dynamic studies is described. Examples of various investigations are reviewed. The dynamics of shallow lakes can be found and expressed in terms of transfer functions, axial dispersion models, residence time distributions and sometimes only semiquantitative information about the flow pattern. The dynamics of deep, stratified lakes is more complex and difficult to investigate with tracers. Flow pattern, horizontal and vertical eddy diffusivities, mass transfer between the hypolimnion and epilimnion are tools used for describing this dynamics. (author)

  5. Application of artificial radioactive tracers for groundwater flow

    International Nuclear Information System (INIS)

    Hamza, M.S.; Aly, A.I.M.; Swailem, F.M.; Nada, A.A.; Awad, M.A.

    1989-01-01

    In this work, the groundwater velocity was estimated by applying radioactive tracer techniques: the single well and the multiple well methods. In the first single well method, radioactive iodine-131 was injected in the well and the radioactivity was monitored with time. The groundwater flow was estimated as a function of the concentration dilution factor of the tracer taking into consideration the permeability of the filter screen and the aquifer. The second method (the multiple well technique) is based on direct measuring of the period of time the tracer needs to disperse from the injection well to one of receptor well arranged in a circle around the injection. The latter method was found to be more accurate and reliable and has also the advantage of determining the groundwater velocity and direction of flow as well. The limitations of the single well technique are discussed and a detailed comparison between single and multi-well techniques is given

  6. Live controls for radioisotope tracer food chain experiments using meiofauna

    International Nuclear Information System (INIS)

    Montagna, P.A.

    1983-01-01

    Formalin poisoned samples are inadequate for measuring the amount of label to be subtracted as control values for certain food chain studies that employ radioactive tracers. In some studies, tracer is added just before incubation to label ''food'' during the feeding study. Commonly, parallel, poisoned incubations are used to distinguish between biotic and abiotic label incorporation. But, a poisoned control does not account for label that could enter a consumer via active transport, epicuticular microfloral uptake, or grazing on labeled, non-food particles. Experiments were performed to test if label uptake is greater in live non-grazing than dead organisms. Marine benthic meiofauna incoporate from 3 to 133 times more tracer when they are alive and not grazing than when they are formalin killed. These results suggest that control experiments with live animals be performed to measure all processes by which label can enter consumers in food chain experiments. (orig.)

  7. Holdup time measurement by radioactive tracers in pulp production

    International Nuclear Information System (INIS)

    Roetzer, H.; Donhoffer, D.

    1988-12-01

    A batch of pulp was to be labelled before passing two bleaching towers of a pulp plant. Activated glass fibres were used as a tracer, which contained 24-Na with a half-life of 15 hours. It was shown in laboratory tests, that the glass fibres were suitable for transport studies of wood pulp. For use in the tests the fibres were activated and suspended in water. Due to the small diameter of the fibres (2-5 micrometers) this suspension shows physical properties very similar to the pulp. For detection six scintillation probes were mounted at different positions outside the bleaching tower. Radiation protection during the test was very easy due to the low total activity of the tracer material. Residence time distributions for both towers were measured. The successful tracer experiments show, that the method of labelling is suited for investigations of material transport in the pulp and paper industry. 3 figs., 11 refs., 2 tabs. (Author)

  8. Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation

    DEFF Research Database (Denmark)

    Kjølby, Birgitte Fuglsang; Østergaard, Leif; Kiselev, Valerij G

    2006-01-01

    The concentration of MRI tracers cannot be measured directly by MRI and is commonly evaluated indirectly using their relaxation effect. This study develops a comprehensive theoretical model to describe the transverse relaxation in perfused tissue caused by intravascular tracers. The model takes...... into account a number of individual compartments. The signal dephasing is simulated in a semianalytical way by embedding Monte Carlo simulations in the framework of analytical theory. This approach yields a tool for fast, realistic simulation of the change in the transverse relaxation. The results indicate...... with bulk blood. The enhancement of relaxation in tissue is due to the contrast in magnetic susceptibility between blood vessels and parenchyma induced by the presence of paramagnetic tracer. Beyond the perfusion measurements, the results can be applied to quantitation of functional MRI and to vessel size...

  9. Contamination tracer testing with seabed drills: IODP Expedition 357

    Directory of Open Access Journals (Sweden)

    B. N. Orcutt

    2017-11-01

    Full Text Available IODP Expedition 357 utilized seabed drills for the first time in the history of the ocean drilling program, with the aim of collecting intact sequences of shallow mantle core from the Atlantis Massif to examine serpentinization processes and the deep biosphere. This novel drilling approach required the development of a new remote seafloor system for delivering synthetic tracers during drilling to assess for possible sample contamination. Here, we describe this new tracer delivery system, assess the performance of the system during the expedition, provide an overview of the quality of the core samples collected for deep biosphere investigations based on tracer concentrations, and make recommendations for future applications of the system.

  10. Dynamics and mechanics of bed-load tracer particles

    Directory of Open Access Journals (Sweden)

    C. B. Phillips

    2014-12-01

    Full Text Available Understanding the mechanics of bed load at the flood scale is necessary to link hydrology to landscape evolution. Here we report on observations of the transport of coarse sediment tracer particles in a cobble-bedded alluvial river and a step-pool bedrock tributary, at the individual flood and multi-annual timescales. Tracer particle data for each survey are composed of measured displacement lengths for individual particles, and the number of tagged particles mobilized. For single floods we find that measured tracer particle displacement lengths are exponentially distributed; the number of mobile particles increases linearly with peak flood Shields stress, indicating partial bed load transport for all observed floods; and modal displacement distances scale linearly with excess shear velocity. These findings provide quantitative field support for a recently proposed modeling framework based on momentum conservation at the grain scale. Tracer displacement is weakly negatively correlated with particle size at the individual flood scale; however cumulative travel distance begins to show a stronger inverse relation to grain size when measured over many transport events. The observed spatial sorting of tracers approaches that of the river bed, and is consistent with size-selective deposition models and laboratory experiments. Tracer displacement data for the bedrock and alluvial channels collapse onto a single curve – despite more than an order of magnitude difference in channel slope – when variations of critical Shields stress and flow resistance between the two are accounted for. Results show how bed load dynamics may be predicted from a record of river stage, providing a direct link between climate and sediment transport.

  11. How well do different tracers constrain the firn diffusivity profile?

    Directory of Open Access Journals (Sweden)

    C. M. Trudinger

    2013-02-01

    Full Text Available Firn air transport models are used to interpret measurements of the composition of air in firn and bubbles trapped in ice in order to reconstruct past atmospheric composition. The diffusivity profile in the firn is usually calibrated by comparing modelled and measured concentrations for tracers with known atmospheric history. However, in most cases this is an under-determined inverse problem, often with multiple solutions giving an adequate fit to the data (this is known as equifinality. Here we describe a method to estimate the firn diffusivity profile that allows multiple solutions to be identified, in order to quantify the uncertainty in diffusivity due to equifinality. We then look at how well different combinations of tracers constrain the firn diffusivity profile. Tracers with rapid atmospheric variations like CH3CCl3, HFCs and 14CO2 are most useful for constraining molecular diffusivity, while &delta:15N2 is useful for constraining parameters related to convective mixing near the surface. When errors in the observations are small and Gaussian, three carefully selected tracers are able to constrain the molecular diffusivity profile well with minimal equifinality. However, with realistic data errors or additional processes to constrain, there is benefit to including as many tracers as possible to reduce the uncertainties. We calculate CO2 age distributions and their spectral widths with uncertainties for five firn sites (NEEM, DE08-2, DSSW20K, South Pole 1995 and South Pole 2001 with quite different characteristics and tracers available for calibration. We recommend moving away from the use of a firn model with one calibrated parameter set to infer atmospheric histories, and instead suggest using multiple parameter sets, preferably with multiple representations of uncertain processes, to assist in quantification of the uncertainties.

  12. Distribution of Isotopic and Environmental Tracers in Groundwater, Northern Ada County, Southwestern Idaho

    Science.gov (United States)

    Adkins, Candice B.; Bartolino, James R.

    2010-01-01

    Residents of northern Ada County, Idaho, depend on groundwater for domestic and agricultural uses. The population of this area is growing rapidly and groundwater resources must be understood for future water-resource management. The U.S. Geological Survey, in cooperation with the Idaho Department of Water Resources, used a suite of isotopic and environmental tracers to gain a better understanding of groundwater ages, recharge sources, and flowpaths in northern Ada County. Thirteen wells were sampled between September and October 2009 for field parameters, major anions and cations, nutrients, oxygen and hydrogen isotopes, tritium, radiocarbon, chlorofluorocarbons, and dissolved gasses. Well depths ranged from 30 to 580 feet below land surface. Wells were grouped together based on their depth and geographic location into the following four categories: shallow aquifer, intermediate/deep aquifer, Willow Creek aquifer, and Dry Creek aquifer. Major cations and anions indicated calcium-bicarbonate and sodium-bicarbonate water types in the study area. Oxygen and hydrogen isotopes carried an oxygen-18 excess signature, possibly indicating recharge from evaporated sources or water-rock interactions in the subsurface. Chlorofluorocarbons detected modern (post-1940s) recharge in every well sampled; tritium data indicated modern water (post-1951) in seven, predominantly shallow wells. Nutrient concentrations tended to be greater in wells signaling recent recharge based on groundwater age dating, thus confirming the presence of recent recharge in these wells. Corrected radiocarbon results generated estimated residence times from modern to 5,100 years before present. Residence time tended to increase with depth, as confirmed by all three age-tracers. The disagreement among residence times indicates that samples were well-mixed and that the sampled aquifers contain a mixture of young and old recharge. Due to a lack of data, no conclusions about sources of recharge could be drawn

  13. MESYST, Simulation of 3-D Tracer Dispersion in Atmosphere

    International Nuclear Information System (INIS)

    Mastrangelo, V.; Mehilli, I.

    2000-01-01

    1 - Description of program or function: Mesyst code is used for the simulation of 3D tracer dispersion in atmosphere. Three packages are part of this system: Cre-topo: prepares the terrain data for the Mesyst. Noabl: code calculates three- dimensional free divergence wind fields over complex terrain. Pas: Computing of tracer concentrations and depositions on a given domain. 2 - Method of solution: NOABL - Line Over Relaxation + Special adaptation of Gauss procedure. PAS - Monte Carlo Method. 3 - Restrictions on the complexity of the problem: Computations: Mesh size: variable from some meters to some hundreds meters Mesh number: variable depending on available real data (some hundreds points on each directions)

  14. Key aspects of stratospheric tracer modeling using assimilated winds

    Directory of Open Access Journals (Sweden)

    B. Bregman

    2006-01-01

    Full Text Available This study describes key aspects of global chemistry-transport models and their impact on stratospheric tracer transport. We concentrate on global models that use assimilated winds from numerical weather predictions, but the results also apply to tracer transport in general circulation models. We examined grid resolution, numerical diffusion, air parcel dispersion, the wind or mass flux update frequency, and time interpolation. The evaluation is performed with assimilated meteorology from the "operational analyses or operational data" (OD from the European Centre for Medium-Range Weather Forecasts (ECMWF. We also show the effect of the mass flux update frequency using the ECMWF 40-year re-analyses (ERA40. We applied the three-dimensional chemistry-transport Tracer Model version 5 (TM5 and a trajectory model and performed several diagnoses focusing on different transport regimes. Covering different time and spatial scales, we examined (1 polar vortex dynamics during the Arctic winter, (2 the large-scale stratospheric meridional circulation, and (3 air parcel dispersion in the tropical lower stratosphere. Tracer distributions inside the Arctic polar vortex show considerably worse agreement with observations when the model grid resolution in the polar region is reduced to avoid numerical instability. The results are sensitive to the diffusivity of the advection. Nevertheless, the use of a computational cheaper but diffusive advection scheme is feasible for tracer transport when the horizontal grid resolution is equal or smaller than 1 degree. The use of time interpolated winds improves the tracer distributions, particularly in the middle and upper stratosphere. Considerable improvement is found both in the large-scale tracer distribution and in the polar regions when the update frequency of the assimilated winds is increased from 6 to 3 h. It considerably reduces the vertical dispersion of air parcels in the tropical lower stratosphere. Strong

  15. Lumped parameter models for the interpretation of environmental tracer data

    International Nuclear Information System (INIS)

    Maloszewski, P.; Zuber, A.

    1996-01-01

    Principles of the lumped-parameter approach to the interpretation of environmental tracer data are given. The following models are considered: the piston flow model (PFM), exponential flow model (EM), linear model (LM), combined piston flow and exponential flow model (EPM), combined linear flow and piston flow model (LPM), and dispersion model (DM). The applicability of these models for the interpretation of different tracer data is discussed for a steady state flow approximation. Case studies are given to exemplify the applicability of the lumped-parameter approach. Description of a user-friendly computer program is given. (author). 68 refs, 25 figs, 4 tabs

  16. Interpretation of the tracer testing conducted in the Leuggern borehole

    International Nuclear Information System (INIS)

    McNeish, J.A.; Andrews, R.W.; Vomvoris, S.

    1990-12-01

    Tracer testing was conducted in the Leuggern borehole from July to December 1988 to evaluate the hydraulic properties of the crystalline host rock. The tested interval was an approximately 50 m section of fractured crystalline rock at a depth of greater than 1,600 m. The testing consisted of three tracer injection/recovery periods (uranin - 44 days, eosin - 30 days, and naphtionat -14 days), which utilized tracer injection/circulation rates, ranging between 25 and 50 ml/min. During these testing periods, tracer was injected in either of two 1/4 flow lines ported at the top or bottom of the interval and recovered from the other. Following the three tracer injection periods, a natural outflow tracer recovery test was conducted from the central tubing at an average outflow of 12 l/min. The central tubing was ported near the center of the test interval. Data collected during the testing periods included: continuous monitoring of fluid temperature, injection pressure, and electrical conductivity as well as discrete measurement of flow rates, electrical conductivity, fluid temperature, and tracer concentration. Testing results indicate a downward vertical flow of approximately 195-225 ml/min in the isolated interval, from an upper fracture inflow zone to a lower fracture outflow zone. Through analysis of the dilution levels of uranin and eosin during the injection/recovery periods, and review of field data, the top of the upper inflow zone was determined to be approximately 13 m below the top flow line and the bottom of the outflow zone to be approximately 3 to 5 meters above the bottom flow line. The calculated transmissivity value of 6E-05 m 2 /s from observed outflow rate and pressure recovery data, is consistent with results derived from previous hydraulic packer testing in the interval. The effective porosity was determined to be 0.1. Dispersion coefficient values ranged from 1.0 m to 5.0 m. The lateral hydraulic gradient value calculated from tracer recovery

  17. Lumped parameter models for the interpretation of environmental tracer data

    Energy Technology Data Exchange (ETDEWEB)

    Maloszewski, P [GSF-Inst. for Hydrology, Oberschleissheim (Germany); Zuber, A [Institute of Nuclear Physics, Cracow (Poland)

    1996-10-01

    Principles of the lumped-parameter approach to the interpretation of environmental tracer data are given. The following models are considered: the piston flow model (PFM), exponential flow model (EM), linear model (LM), combined piston flow and exponential flow model (EPM), combined linear flow and piston flow model (LPM), and dispersion model (DM). The applicability of these models for the interpretation of different tracer data is discussed for a steady state flow approximation. Case studies are given to exemplify the applicability of the lumped-parameter approach. Description of a user-friendly computer program is given. (author). 68 refs, 25 figs, 4 tabs.

  18. Use of radioactive tracers in the semiconductor industry

    International Nuclear Information System (INIS)

    Akerman, Karol

    1975-01-01

    Manufacture of the semiconductor materials comprises production and purification of the raw materials (GeC14 or SiHC13), purification of the elemental semiconductors by metallurgical methods (including zone melting), production and doping of single crystals, dividing the crystals into slices of suitable size, formation of p-n junctions and fabrication of the finished semiconductor devices. In the sequence of operations, the behavior of very small quantities of an element must be monitored, and radioactive tracers are often used to solve these problems. Examples are given of the use of radioactive tracers in the semiconductor industry

  19. Tracer techniques for determination of groundwater flow parameters

    International Nuclear Information System (INIS)

    Drost, W.; Klotz, D.

    1988-05-01

    The most common one-borehole and multiple borehole methods using tracers for the direct determination of the groundwater flow parameters (velocity of flow, flow direction) and for the indirect determination of characteristic quantities of the aquifer (effective porosity, dispersivity, transmissivity) are presented methodically and their value is documented by practical examples. Especially, the properties of and measuring technique with suitable tracers are considered (e.g. T, Na-24, Cr-51, Co-58, Co-60, Br-82, Tc-99, I-125, I-131, Au-198). (orig./HP) [de

  20. A model for C-14 tracer evaporative rate analysis (ERA)

    International Nuclear Information System (INIS)

    Gardner, R.P.; Verghese, K.

    1993-01-01

    A simple model has been derived and tested for the C-14 tracer evaporative rate analysis (ERA) method. It allows the accurate determination of the evaporative rate coefficient of the C-14 tracer detector in the presence of variable evaporation rates of the detector solvent and variable background counting rates. The evaporation rate coefficient should be the most fundamental parameter available in this analysis method and, therefore, its measurements with the proposed model should allow the most direct correlations to be made with the system properties of interest such as surface cleanliness. (author)

  1. Interwell tracer analyses of a hydraulically fractured granitic geothermal reservoir

    International Nuclear Information System (INIS)

    Tester, J.W.; Potter, R.M.; Bivins, R.L.

    1979-01-01

    Field experiments using fluorescent dye and radioactive tracers (Br 82 and I 131 ) have been employed to characterize a hot, low-matrix permeability, hydraulically-fractured granitic reservoir at depths of 2440 to 2960 m (8000 to 9700 ft). Tracer profiles and residence time distributions have been used to delineate changes in the fracture system, particularly in diagnosing pathological flow patterns and in identifying new injection and production zones. The effectiveness of one- and two-dimensional theoretical dispersion models utilizing single and multiple porous, fractured zones with velocity and formation dependent effects are discussed with respect to actual field data

  2. Experiments to Evaluate and Implement Passive Tracer Gas Methods to Measure Ventilation Rates in Homes

    Energy Technology Data Exchange (ETDEWEB)

    Lunden, Melissa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Faulkner, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Heredia, Elizabeth [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cohn, Sebastian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dickerhoff, Darryl [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Noris, Federico [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Logue, Jennifer [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hotchi, Toshifumi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singer, Brett [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sherman, Max H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-10-01

    This report documents experiments performed in three homes to assess the methodology used to determine air exchange rates using passive tracer techniques. The experiments used four different tracer gases emitted simultaneously but implemented with different spatial coverage in the home. Two different tracer gas sampling methods were used. The results characterize the factors of the execution and analysis of the passive tracer technique that affect the uncertainty in the calculated air exchange rates. These factors include uncertainties in tracer gas emission rates, differences in measured concentrations for different tracer gases, temporal and spatial variability of the concentrations, the comparison between different gas sampling methods, and the effect of different ventilation conditions.

  3. On the use of flow-storage repartitions derived from artificial tracer tests for geothermal reservoir characterization in the Malm-Molasse basin: a theoretical study

    Science.gov (United States)

    Dewi, Dina Silvia; Osaigbovo Enomayo, Augustine; Mohsin, Rizwan; Karmakar, Shyamal; Ghergut, Julia; Sauter, Martin

    2016-04-01

    needed to calculate FSR. Looking at the Sauerlach example, we find that premature interruption of tracer sampling systematically leads to overestimating the reservoir's storage capacity and underestimating its flow capacity, with misestimation generally increasing as the bedded/reef interfacial area per volume is increased. It is interesting to correlate these findings with the tracer-based approach to facies identification for the shallower Malm aquifers of the Southern Franconian Alb, proposed by Seiler et al. (1989, 1995) and with expectations from the direct (i. e., distributed-parameter) modeling of matrix-diffusive effects (Maloszewski and Zuber 1985) on measured tracer signals. References: Maloszewski P, Zuber A (1985) On the theory of tracer experiments in fissured rocks with a porous matrix, Journal of Hydrology, 79, 333-358 Seiler K-P, Behrens H, Wolf M (1995) Use of artificial and environmental tracers to study storage and drainage of groundwater in the Franconian Alb, Germany, and the consequences for groundwater protection, Proc Isotopes in Water Resources Management, 2, 135-146 (IAEA, Vienna) Seiler K-P, Maloszewski P, Behrens H (1989) Hydrodynamic dispersion in karstified limestones and dolomites in the Upper Jurassic of the Franconian Alb, FRG, Journal of Hydrology, 108, 235-247 Shook G M (2003) A Simple, Fast Method of Estimating Fractured Reservoir Geometry from Tracer Tests, Geothermal Resources Council Transactions, 27, 407-411 Financial support from the German Federal Ministry for Economic Affairs and Energy is gratefully acknowledged. - Gefördert durch BMWi aufgrund eines Beschlusses des Deutschen Bundestages (FKZ 0325515 "TRENDS").

  4. A review: radiolabeled synthesis of pesticides

    International Nuclear Information System (INIS)

    Li Juying; Han Ailiang; Wang Haiyan; Wang Wei; Ye Qingfu

    2010-01-01

    Isotope tracer technique has been widely applied in studies of metabolism, mode action, fate and environmental behavior of pesticides. In such studies, the key point is to obtain suitable radiolabelled compounds. However, the radiotracers, especially the labelled pesticides which are novel compounds with complex structures and longer synthesis routes, are usually unavailable from domestic and /or foreign markets. Therefore, it is essential to explore the synthesis methods of radiolabelled pesticides, which are quite different from the conventional nonradiosynthesis, and are requested to obtain higher yield. This article is a review on current status of choosing the available radionuclide and labelled position, the main synthesis methods and problems in the process of preparing radiolabelled pesticides. (authors)

  5. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site characterization study

    International Nuclear Information System (INIS)

    Dombrowski, T.; Stetzenbach, K.

    1993-01-01

    This report is in two parts one for the fluorinated benzoic acids and one for the fluorinated aliphatic acids. The assumptions made in the report regarding the amount of tracer that will be used, dilution of the tracer during the test and the length of exposure (if any) to individuals drinking the water were made by the authors. These assumptions must really come from the USGS hydrologists in charge of the c-well tracer testing program. Accurate estimates of dilution of the tracer during the test are also important because of solubility limitations of some of the tracers. Three of the difluorobenzoic acids have relatively low solubilities and may not be usable if the dilution estimates are large. The toxicologist that reviewed the document agreed with our conclusion that the fluorinated benzoic and toluic acids do not represent a health hazard if used under the conditions as outlined in the report. We are currently testing 15 of these compounds, and if even if three difluorobenzoic acids cannot be used because of solubility limitations we will still have 12 tracers. The toxicologist felt that the aliphatic fluorinated acids potentially present more of a health risk than the aromatic. This assessment was based on the fact of a known allergic response to halothane anesthetic. This risk, although minimal, is known and he felt that was enough reason to recommend against their use. The authors feel that the toxicologists interpretation of this risk was overly conservative, however, we will not go against his recommendation at this time for the following reasons. First, without the aliphatic compounds we still have 12 to 15 fluorinated aromatic acids which, should be enough for the c-well tests. Second, to get a permit to use aliphatic compounds would undoubtedly require a hearing which could be quite lengthy

  6. Radon-222 and beryllium-7 as natural tracer; Radon-222 und Beryllium-7 als natuerliche Tracer

    Energy Technology Data Exchange (ETDEWEB)

    Frank, G.; Steinkopff, T. [Deutscher Wetterdienst, Offenbach (Germany). Radioaktivitaetsueberwachung; Salvamoser, J. [Institut fuer Angewandte Isotopen-, Gas- und Umweltuntersuchungen (IGU), Woerthsee (Germany)

    2016-07-01

    The Global Atmosphere Watch Program (GAW) is intended to analyse worldwide the influence of anthropogenic emissions to the atmosphere. Data are continuously transferred to the ''World Data Centre for Green House Gases'' of the WMO. For the study of atmospheric transports the natural radionuclides Rn-222, Be-7, Pb-210, Pb- 214 and Bi-214 are continuously measured at the Umweltforschungsstation Schneefernerhaus (2650 m) and at the Zugspitze (2962 m) by the Deutscher Wetterdienst (DWD, German Weather Service). The measurements support the classification of atmospheric transport, atmospheric dilution and dispersion models of gaseous and aerosol bond micro pollutants. Results are carried out in combination with meteorological data. It is shown the optimization and effect of a new sampling site for the measurement of Rn-222 activity at the Zugspitze. Results of Rn-222 and Be-7 concentrations are shown in relation to horizontal and vertical dispersion of air masses. The origin of natural Rn-222 and Be-7 are known, therefore both nuclides are well suited for the research of atmospheric transport. Rn-222 is an ideal tracer, because there is no influence by atmospheric processes (chemical processes, wash out effects).

  7. Iodine 123-antipyrine. A diffusible tracer for brain exploration

    International Nuclear Information System (INIS)

    Dantonel-Mathieu, Evelyne.

    1978-09-01

    Iodine 123-labelled iodoantipyrine is a liposoluble diffusible tracer which crosses the blood-brain barrier intact. Its build-up in brain tissue is proportional to the regional blood flow. Its behavior was studied in undervascularised brain lesions and in cases where research with traditional radioactive tracers (99mTc and its different vectors for example) has proved limited. Because of the great diffusibility of iodoantipyrine a brain parenchyma image is obtained within minutes after its injection, and this by the use of a non-invasive technique and under good gamma-camera exploration conditions. 81 brain explorations including 11 standards have been carried out on subjects averaging 51,2 years old; these examinations took place in three nuclear medicine centres. The 123 I iodoantipyrine used in each nuclear medicine centre is supplied by the CEA. Iodoantipyrine is labelled with a good yield (>98%) checked by chromatography by means of a CEA kit. After intraveinous injection of 4 to 6 mCi iodine-123 iodoantipyrine, a dynamic study (from 0 to 60 seconds) of the tracer passage in the brain tissue may be followed by static images taken in the next minutes according to a standard procedure. The table of results shows the major interest of this tracer for the exploration of vascular accidents with ischemic lesions, especially in the early phase of the accident. The lesion appears as a hypoactive zone and this lack of perfusion lasts for some minutes after the injection [fr

  8. Using radioactive tracers for the evaluation of industrial equipment

    International Nuclear Information System (INIS)

    Brandao, Luis Eduardo Barreira; Sa, Lidia Vasconcellos de; Sousa, Alvaro Serafim F. de

    2000-01-01

    This paper presents the radioactive tracer technique, giving as example some cases of the possible utilization developed by the Nuclear Engineering Institute, RJ, BR (Argonaut reactor) and through charged particle (CV-28 cyclotron), and also his production and aspects of radiological safety

  9. Accurate assessment of exposure using tracer gas measurements

    DEFF Research Database (Denmark)

    Kierat, Wojciech; Bivolarova, Mariya; Zavrl, Eva

    2018-01-01

    analyzers with short and long response times, respectively. The tracer gas concentration was characterized by the mean, standard deviation and 95th percentile values. The results revealed that the measurement time needed to determine, with sufficient accuracy, these parameters decreased substantially...

  10. Radiation dose estimates for carbon-11-labelled PET tracers

    International Nuclear Information System (INIS)

    Aart, Jasper van der; Hallett, William A.; Rabiner, Eugenii A.; Passchier, Jan; Comley, Robert A.

    2012-01-01

    Introduction: Carbon-11-labelled positron emission tomography (PET) tracers commonly used in biomedical research expose subjects to ionising radiation. Dosimetry is the measurement of radiation dose, but also commonly refers to the estimation of health risk associated with ionising radiation. This review describes radiation dosimetry of carbon-11-labelled molecules in the context of current PET research and the most widely used regulatory guidelines. Methods: A MEDLINE literature search returned 42 articles; 32 of these were based on human PET data dealing with radiation dosimetry of carbon-11 molecules. Radiation burden expressed as effective dose and maximum absorbed organ dose was compared between tracers. Results: All but one of the carbon-11-labelled PET tracers have an effective dose under 9 μSv/MBq, with a mean of 5.9 μSv/MBq. Data show that serial PET scans in a single subject are feasible for the majority of radiotracers. Conclusion: Although differing in approach, the two most widely used regulatory frameworks (those in the USA and the EU) do not differ substantially with regard to the maximum allowable injected activity per PET study. The predictive validity of animal dosimetry models is critically discussed in relation to human dosimetry. Finally, empirical PET data are related to human dose estimates based on homogenous distribution, generic models and maximum cumulated activities. Despite the contribution of these models to general risk estimation, human dosimetry studies are recommended where continued use of a new PET tracer is foreseen.

  11. Production of a tracer packet of heavier rare earth elements

    International Nuclear Information System (INIS)

    Lahiri, S.; Nayak, D.; Maji, S.

    2004-01-01

    Production of a tracer packet of heavier rare earth elements containing carrier-free radionuclides of 153,155 Tb, 153,155,157 Dy, 159 Ho, 159,161 Er, 161 Tm produced by medium energy 7 Li and 12 C irradiation on an europium oxide target and the subsequent separation of bulk europium from the carrier-free products is described. (author)

  12. Molecules as tracers of galaxy evolution: an EMIR survey

    DEFF Research Database (Denmark)

    Costagliola, F.; Aalto, S.; I. Rodriguez, M.

    2011-01-01

    We investigate the molecular gas properties of a sample of 23 galaxies in order to find and test chemical signatures of galaxy evolution and to compare them to IR evolutionary tracers. Observation at 3 mm wavelengths were obtained with the EMIR broadband receiver, mounted on the IRAM 30 m telesco...

  13. Uptake and transport of positron-emitting tracer in plants

    Energy Technology Data Exchange (ETDEWEB)

    Kume, Tamikazu; Matsuhashi, Shinpei; Shimazu, Masamitsu [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment; and others

    1997-03-01

    The transport of a positron-emitting isotope introduced into a plant was dynamically followed by a special observation apparatus called `Positron-Emitting Tracer Imaging System`. In the system, annihilation {gamma}-rays from the positron emitter are detected with two planer detectors (5 x 6 cm square). The water containing ca. 5 MBq/ml of {sup 18}F was fed to the cut stem of soybean for 2 min and then the images of tracer activity were recorded for 30 - 50 min. When the midrib of a leaf near the petiole was cut just before measurement, the activity in the injured leaf was decreased but detected even at the apex. This result suggests that the damaged leaf recovered the uptake of water through the lamina. Maximum tracer activities in leaves of unirradiated plant were observed within 10 min, whereas those of irradiated plant at 100 Gy were observed after over 25 min. The final activity of irradiated plant after 30 min was lower than that of unirradiated plant. In case of beans, there was a difference in the absorption behavior of the {sup 18}F-labeled water between unirradiated and irradiated samples. These results show that the system is effective to observe the uptake and transportation of water containing positron emitting tracer for the study of damage and recovery functions of plants. (author)

  14. Off-gassing induced tracer release from molten basalt pools

    International Nuclear Information System (INIS)

    Cronenberg, A.W.; Callow, R.A.

    1994-01-01

    Two in situ vitrification (ISV) field tests were conducted at the Idaho National Engineering Laboratory (INEL) during the summer of 1990 to assess ISV suitability for long-term stabilization of buried waste that contains transuranic and other radionuclide contaminants. The ISV process uses electrical resistance heating to melt buried waste and soil in place, which upon cooldown and resolidification fixes the waste into a vitrified (glass-like) form. In these two ISV field tests, small quantities of rare-earth oxides (tracers DY 2 O 3 , Yb 2 O 3 , and Tb 4 O 7 ) were placed in the test pits to simulate the presence of plutonium oxides and assess plutonium retention/release behavior. The analysis presented in this report indicates that dissolution of tracer oxides into basaltic melts can be expected with subsequent tracer molecular or microparticle carry-off by escaping gas bubbles, which is similar to adsorptive bubble separation and ion flotation processes employed in the chemical industry to separate dilute heavy species from liquids under gas sparging conditions. Gaseous bubble escape from the melt surface and associated aerosolization is believed to be responsible for small quantities of tracer ejection from the melt surface to the cover hood and off-gas collection system. Methods of controlling off-gassing during ISV would be expected to improve the overall retention of such heavy oxide contaminants during melting/vitrification of buried waste

  15. TRAC, a collaborative computer tool for tracer-test interpretation

    Directory of Open Access Journals (Sweden)

    Fécamp C.

    2013-05-01

    Full Text Available Artificial tracer tests are widely used by consulting engineers for demonstrating water circulation, proving the existence of leakage, or estimating groundwater velocity. However, the interpretation of such tests is often very basic, with the result that decision makers and professionals commonly face unreliable results through hasty and empirical interpretation. There is thus an increasing need for a reliable interpretation tool, compatible with the latest operating systems and available in several languages. BRGM, the French Geological Survey, has developed a project together with hydrogeologists from various other organizations to build software assembling several analytical solutions in order to comply with various field contexts. This computer program, called TRAC, is very light and simple, allowing the user to add his own analytical solution if the formula is not yet included. It aims at collaborative improvement by sharing the tool and the solutions. TRAC can be used for interpreting data recovered from a tracer test as well as for simulating the transport of a tracer in the saturated zone (for the time being. Calibration of a site operation is based on considering the hydrodynamic and hydrodispersive features of groundwater flow as well as the amount, nature and injection mode of the artificial tracer. The software is available in French, English and Spanish, and the latest version can be downloaded from the web site http://trac.brgm.fr.

  16. Circulation of cerebrospinal fluid. Comparative study of various tracers

    International Nuclear Information System (INIS)

    Bok, B.; Thebault, B.; Cavailloles, F.; Aboulker, J.

    1977-01-01

    The dynamics of cerebrospinal fluid in the spinal subarachnoid space is studied by gammamyelography. There are still controversies about the ideal properties of the tracer to be used. The influence of the tracer's molecular weight on the kinetic of ascent in the medullar cerebrospinal fluid with a view to rating the criterias for choice of an available radiopharmaceutical was evaluated. Three compounds injected simultaneously through a lombar puncture were compared: indium 111 labelled transferrin, iodine 131 labelled human serum albumin and technetium 99m labelled diethylenetriaminepentaacetic acid. The individual stability of the compounds and a possible interference between them was investigated especially by electrophoretic technics. A spectrometric study showed that it is possible to simultaneously identify and count each of the isotopes included in the mixture on the detector device: an hybrid scanner. The comparison of linear activity profils collected on phantoms and on ten patients showed a similar fate of the three compounds during the first hours of the investigation studying the ascent of tracers into basal cisterns either in normal or pathological patients. It is therefore concluded that molecular weight does not influence in a detectable manner the spinal C.S.F. kinetics of the radiopharmaceuticals. This allows the use of the most convenient and best tolerated tracer from the dosimetric and toxicological stand point [fr

  17. Accuracy of tracer stimulus response experiments in laminar flows

    Czech Academy of Sciences Publication Activity Database

    Chlup, Hynek; Novotný, Pavel; Žitný, R.

    2012-01-01

    Roč. 55, 23-24 (2012), s. 6458-6462 ISSN 0017-9310 Institutional research plan: CEZ:AV0Z20760514 Keywords : residence time distribution * tracer injection * laminar convective dominated flow Subject RIV: JB - Sensors, Measurment, Regulation Impact factor: 2.315, year: 2012 http://www.sciencedirect.com/science/article/pii/S001793101200470X

  18. Atlantic Coast Unique Regional Atmospheric Tracer Experiment (ACURATE)

    International Nuclear Information System (INIS)

    Schubert, J.F.; Heffter, J.L.; Mead, G.A.

    1985-01-01

    A long-range, long-term data set on the regional scale for air pollution model was developed for evaluation. The ACURATE model used Kr-85 emitted intermittently from the Savannah River Plant as a tracer of hourly source emission data at 5 sites for a total of 3858 measurements

  19. Joint interpretation of two tracer tests with reversed flow fields

    International Nuclear Information System (INIS)

    Kunstmann, H.; Kinzelbach, W.; Marschall, P.; Li, G.

    1995-01-01

    Two dipole tracer experiments were performed in a fractured rock at the Grimsel Test Site in February/March 1993. In both experiments NaCl was used as a tracer. The extraction rate was twice the injection rate. In the second experiment injection and extraction were interchanged (Reverse-Experiment). Long tailing was characteristic for the breakthrough curves in both experiments. The tests were interpreted using a single fracture flow model. Tracer transport is described by advection/dispersion along the fracture allowing for diffusion into an immobile matrix. The authors were able to interpret the breakthrough curves for both experiments by one unique set of parameters, describing transport and baseflow. Uniqueness could only be achieved when using the information of both experiments. The authors conclude that performing a Reverse-Experiment is an indispensable tool for parameter identification in dipole tracer tests. A sensitivity analysis suggested that not only matrix diffusion is responsible for the tailing in the breakthrough curves but also transversal dispersivity. Further, the typical exchange time between mobile and immobile media was too small to be attributed to matrix diffusion in the strict sense which will cause tailing even at large spatial and temporal scales. Analysis of the covariance matrices showed that the parameters have small errors but high correlation

  20. Diagnostic Implications of the Reactivity of Fluorescence Tracers

    Energy Technology Data Exchange (ETDEWEB)

    Sick, V; Westbrook, C

    2008-07-14

    Measurements of fuel concentration distributions with planar laser induced fluorescence of tracer molecules that are added to a base fuel are commonly used in combustion research and development. It usually is assumed that the tracer concentration follows the parent fuel concentration if physical properties such as those determining evaporation are matched. As an example to address this general issue a computational study of combustion of biacetyl/iso-octane mixtures was performed to investigate how well the concentration of biacetyl represents the concentration of iso-octane. For premixed mixture conditions with flame propagation the spatial concentration profiles of the two species in the flame front are separated by 110 {micro}m at 1 bar and by 11 {micro}m at 10 bar. For practical applications this spatial separation is insignificantly small. However, for conditions that mimic ignition and combustion in diesel and HCCI-like operation the differences in tracer and fuel concentration can be significant, exceeding hundreds of percent. At low initial temperature biacetyl was found to be more stable whereas at higher temperature (>1000K) iso-octane is more stable. Similar findings were obtained for a multi-component fuel comprised of iso-octane, n-heptane, methylcyclohexane, and toluene. It may be assumed that similar differences can exist for other tracer/fuel combinations. Caution has therefore to be applied when interpreting PLIF measurements in homogeneous reaction conditions such as in HCCI engine studies.

  1. Tracer investigations of natural and polluted sea sediment movement

    International Nuclear Information System (INIS)

    Pruszak, Z.

    1994-01-01

    Results of tracer investigations and bottom sediment movement analysis (natural and polluted) performed world-wide have been shown. Polish investigations have been compared to these results. A critical estimation and analysis of particular elements of sediment movement: thickness of the drag layer and various characteristics of bottom transport evaluated in different time-space scales has been performed. 14 refs, 9 figs

  2. Radioactive tracers in the assessment of cleaning of surgical appliances

    International Nuclear Information System (INIS)

    Mostafa, A.B.M.G.; Chackett, K.F.

    1975-01-01

    Radioactive tracers which may be used in the assessment of cleaning of surgical appliances are described. Five labelled compounds were used as soiling material and tested in the rather severe conditions that exist during cleaning cycles. Measurements of decontamination in two cases were considered reliable but in the other three some degree of decomposition of the soil occurred, which falsified the results. (author)

  3. General circulation and tracers: studies in the Western Indian Ocean

    International Nuclear Information System (INIS)

    Jamous, Daniel

    1991-01-01

    The main question addressed in this thesis is how to best use the information obtained from hydro-biogeochemical tracer data, to study the oceanic general circulation in the Western Indian Ocean. First, a principal component analysis is performed on a historical data set. The tracers considered are temperature, salinity, density, oxygen, phosphate and silica. The method reduces the amount of data to be considered by a factor of 5. It reproduces correctly and efficiently the large-scale distributions of these oceanic properties. The analysed data are then used in a finite-difference nonlinear inverse model. The grid has a resolution of 4 deg. by 4 deg.. Dynamical as well as tracer conservation constraints are used. These constraints are well satisfied by the obtained solutions but the associated errors remain large. Additional constraints would be required in order to discuss the different solutions in more detail. Finally, a qualitative study is done on the deep distribution of helium-3. The data show several important features linked to hydrothermal input in the Gulf of Aden and on the Central Indian Ridge, and to the origin of water masses and deep circulation characteristics. However additional data are required in order to clarify the distribution of this tracer in other key areas. (author) [fr

  4. Interest of radioactive tracers in fruit cultivation research

    International Nuclear Information System (INIS)

    Ferauge, M.T.; Dreze, Ph.

    1976-01-01

    The authors report some results related to the use of tracer techniques applied to nutrition and physiological diseases of fruit trees. Penetration and fate of several mineral and organic elements either by root system or by aerial parts of the trees are studied. (J.C.)

  5. How to Program a Domain Independent Tracer for Explanations

    Science.gov (United States)

    Ishizaka, Alessio; Lusti, Markus

    2006-01-01

    Explanations are essential in the teaching process. Tracers are one possibility to provide students with explanations in an intelligent tutoring system. Their development can be divided into four steps: (a) the definition of the trace model; (b) the extraction of the information from this model; (c) the analysis and abstraction of the extracted…

  6. The use of radioisotope tracers in the metallurgical industries

    International Nuclear Information System (INIS)

    Easey, J.F.

    1987-01-01

    Radioisotope techniques have been widely used in the metallurgical industries for many years. They have been shown to be very suitable for studying large scale plant and, in many cases, they are the most suitable techniques for such investigations. Applications of radioisotope tracers to some specific metallurgical problems are discussed. (author)

  7. Unit vent airflow measurements using a tracer gas technique

    Energy Technology Data Exchange (ETDEWEB)

    Adams, D.G. [Union Electric Company, Fulton, MO (United States); Lagus, P.L. [Lagus Applied Technology, Inc., San Diego, CA (United States); Fleming, K.M. [NCS Corp., Columbus, OH (United States)

    1997-08-01

    An alternative method for assessing flowrates that does not depend on point measurements of air flow velocity is the constant tracer injection technique. In this method one injects a tracer gas at a constant rate into a duct and measures the resulting concentration downstream of the injection point. A simple equation derived from the conservation of mass allows calculation of the flowrate at the point of injection. Flowrate data obtained using both a pitot tube and a flow measuring station were compared with tracer gas flowrate measurements in the unit vent duct at the Callaway Nuclear Station during late 1995 and early 1996. These data are presented and discussed with an eye toward obtaining precise flowrate data for release rate calculations. The advantages and disadvantages of the technique are also described. In those test situations for which many flowrate combinations are required, or in large area ducts, a tracer flowrate determination requires fewer man-hours than does a conventional traverse-based technique and does not require knowledge of the duct area. 6 refs., 10 figs., 6 tabs.

  8. In-situ testing methods using radioactive tracers

    International Nuclear Information System (INIS)

    Sauzay, G.

    1976-01-01

    Some typical applications of tracer techniques in hydrology are presented: study of the extraction of sands and gravels in a estuary; in-situ study of the transport of sediments by the swell at a depth ranging from 8 to 22m; study of the transport of sands on the site Bonne Anse - Saint Palais [fr

  9. 76 FR 71610 - Market Test of First-Class Tracer

    Science.gov (United States)

    2011-11-18

    ... electronically by accessing the ``Filing Online'' link in the banner at the top of the Commission's Web site... Commission. Id. at 6. A First-Class Tracer, which consists of a barcoded label, tracing number, and QR Code... 28, 2011. The filing can be accessed via the Commission's Web site ( http://www.prc.gov ). The...

  10. Lagrangian Transport Calculations Using UARS Data. Part I: Passive Tracers

    Science.gov (United States)

    Manney, G. L.; Lahoz, W. A.; Harwood, R. S.; Zurek, R. W.; Kumer, J. B.; Mergenthaler, J. L.; Roche, A. E.; O'Neill, A; Swinbank, R.; Waters, J. W.

    1994-01-01

    The transport of passive tracers observed by UARS has been simulated using computed trajectories of thousands of air parcels initialized on a three-dimensional stratospheric grid. These trajectories are calculated in isentropic coordinates using horizontal winds provided by the United Kingdom Meteorological Office data assimilation system and vertical (cross-isentropic) velocities computed using a fast radiation code.

  11. Synthesis of natural products of therapeutic significance

    Indian Academy of Sciences (India)

    system

    2015-11-07

    Nov 7, 2015 ... potential activity, while more natural products await the ... Treaty that prohibits commercial exploitation of Antarctic resources, the development of a synthetic strategy that allows the synthesis of palmerolide A and an array of its.

  12. Fluorescence guided surgery and tracer-dose, fact or fiction?

    International Nuclear Information System (INIS)

    KleinJan, Gijs H.; Olmos, Renato A.V.; Bunschoten, Anton; Berg, Nynke S. van den; Klop, W.M.C.; Horenblas, Simon; Poel, Henk G. van der; Wester, Hans-Juergen; Leeuwen, Fijs W.B. van

    2016-01-01

    Fluorescence guidance is an upcoming methodology to improve surgical accuracy. Challenging herein is the identification of the minimum dose at which the tracer can be detected with a clinical-grade fluorescence camera. Using a hybrid tracer such as indocyanine green (ICG)- 99m Tc-nanocolloid, it has become possible to determine the accumulation of tracer and correlate this to intraoperative fluorescence-based identification rates. In the current study, we determined the lower detection limit of tracer at which intraoperative fluorescence guidance was still feasible. Size exclusion chromatography (SEC) provided a laboratory set-up to analyze the chemical content and to simulate the migratory behavior of ICG-nanocolloid in tissue. Tracer accumulation and intraoperative fluorescence detection findings were derived from a retrospective analysis of 20 head-and-neck melanoma patients, 40 penile and 20 prostate cancer patients scheduled for sentinel node (SN) biopsy using ICG- 99m Tc-nanocolloid. In these patients, following tracer injection, single photon emission computed tomography fused with computed tomography (SPECT/CT) was used to identify the SN(s). The percentage injected dose (% ID), the amount of ICG (in nmol), and the concentration of ICG in the SNs (in μM) was assessed for SNs detected on SPECT/CT and correlated with the intraoperative fluorescence imaging findings. SEC determined that in the hybrid tracer formulation, 41 % (standard deviation: 12 %) of ICG was present in nanocolloid-bound form. In the SNs detected using fluorescence guidance a median of 0.88 % ID was present, compared to a median of 0.25 % ID in the non-fluorescent SNs (p-value < 0.001). The % ID values could be correlated to the amount ICG in a SN (range: 0.003-10.8 nmol) and the concentration of ICG in a SN (range: 0.006-64.6 μM). The ability to provide intraoperative fluorescence guidance is dependent on the amount and concentration of the fluorescent dye accumulated in the lesion(s) of

  13. Numerical simulations of the spread of floating passive tracer released at the Old Harry prospect

    Science.gov (United States)

    Bourgault, Daniel; Cyr, Frédéric; Dumont, Dany; Carter, Angela

    2014-05-01

    The Gulf of St Lawrence is under immediate pressure for oil and gas exploration, particularly at the Old Harry prospect. A synthesis of the regulatory process that has taken place over the last few years indicates that important societal decisions soon to be made by various ministries and environmental groups are going to be based on numerous disagreements between the private sector and government agencies. The review also shows that the regulatory process has taken place with a complete lack of independent oceanographic research. Yet, the Gulf of St Lawrence is a complex environment that has never been specifically studied for oil and gas exploitation. Motivated by this knowledge gap, preliminary numerical experiments are carried out where the spreading of a passive floating tracer released at Old Harry is examined. Results indicate that the tracer released at Old Harry may follow preferentially two main paths. The first path is northward along the French Shore of Newfoundland, and the second path is along the main axis of the Laurentian Channel. The most probable coastlines to be touched by water flowing through Old Harry are Cape Breton and the southern portion of the French Shore, especially Cape Anguille and the Port au Port Peninsula. The Magdalen Islands are less susceptible to being affected than those regions but the probability is not negligible. These preliminary results provide guidance for future more in-depth and complete multidisciplinary studies from which informed decision-making scenarios could eventually be made regarding the exploration and development of oil and gas at the Old Harry prospect in particular and, more generally, in the Gulf of St Lawrence.

  14. Numerical simulations of the spread of floating passive tracer released at the Old Harry prospect

    International Nuclear Information System (INIS)

    Bourgault, Daniel; Cyr, Frédéric; Dumont, Dany; Carter, Angela

    2014-01-01

    The Gulf of St Lawrence is under immediate pressure for oil and gas exploration, particularly at the Old Harry prospect. A synthesis of the regulatory process that has taken place over the last few years indicates that important societal decisions soon to be made by various ministries and environmental groups are going to be based on numerous disagreements between the private sector and government agencies. The review also shows that the regulatory process has taken place with a complete lack of independent oceanographic research. Yet, the Gulf of St Lawrence is a complex environment that has never been specifically studied for oil and gas exploitation. Motivated by this knowledge gap, preliminary numerical experiments are carried out where the spreading of a passive floating tracer released at Old Harry is examined. Results indicate that the tracer released at Old Harry may follow preferentially two main paths. The first path is northward along the French Shore of Newfoundland, and the second path is along the main axis of the Laurentian Channel. The most probable coastlines to be touched by water flowing through Old Harry are Cape Breton and the southern portion of the French Shore, especially Cape Anguille and the Port au Port Peninsula. The Magdalen Islands are less susceptible to being affected than those regions but the probability is not negligible. These preliminary results provide guidance for future more in-depth and complete multidisciplinary studies from which informed decision-making scenarios could eventually be made regarding the exploration and development of oil and gas at the Old Harry prospect in particular and, more generally, in the Gulf of St Lawrence

  15. Challenging (Strategic) Human Resource management Theory

    NARCIS (Netherlands)

    J. Paauwe (Jaap); J.P.P.E.F. Boselie (Paul)

    2002-01-01

    textabstractTo fully understand the relationship between human resource management and performance in different contexts, we are in need of a synthesis between resource-based theory and new institutionalism. We argue that differences in institutional settings (between for example countries or

  16. INTRAVAL Finnsjoen Test - modelling results for some tracer experiments

    International Nuclear Information System (INIS)

    Jakob, A.; Hadermann, J.

    1994-09-01

    This report presents the results within Phase II of the INTRAVAL study. Migration experiments performed at the Finnsjoen test site were investigated. The study was done to gain an improved understanding of not only the mechanisms of tracer transport, but also the accuracy and limitations of the model used. The model is based on the concept of a dual porosity medium, taking into account one dimensional advection, longitudinal dispersion, sorption onto the fracture surfaces, diffusion into connected pores of the matrix rock, and sorption onto matrix surfaces. The number of independent water carrying zones, represented either as planar fractures or tubelike veins, may be greater than one, and the sorption processes are described either by linear or non-linear Freundlich isotherms assuming instantaneous sorption equilibrium. The diffusion of the tracer out of the water-carrying zones into connected pore space of the adjacent rock is calculated perpendicular to the direction of the advective/dispersive flow. In the analysis, the fluid flow parameters are calibrated by the measured breakthrough curves for the conservative tracer (iodide). Subsequent fits to the experimental data for the two sorbing tracers strontium and cesium then involve element dependent parameters providing information on the sorption processes and on its representation in the model. The methodology of fixing all parameters except those for sorption with breakthrough curves for non-sorbing tracers generally worked well. The investigation clearly demonstrates the necessity of taking into account pump flow rate variations at both boundaries. If this is not done, reliable conclusions on transport mechanisms or geometrical factors can not be achieved. A two flow path model reproduces the measured data much better than a single flow path concept. (author) figs., tabs., 26 refs

  17. Use of natural geochemical tracers to improve reservoir simulation models

    Energy Technology Data Exchange (ETDEWEB)

    Huseby, O.; Chatzichristos, C.; Sagen, J.; Muller, J.; Kleven, R.; Bennett, B.; Larter, S.; Stubos, A.K.; Adler, P.M.

    2005-01-01

    This article introduces a methodology for integrating geochemical data in reservoir simulations to improve hydrocarbon reservoir models. The method exploits routine measurements of naturally existing inorganic ion concentration in hydrocarbon reservoir production wells, and uses the ions as non-partitioning water tracers. The methodology is demonstrated on a North Sea field case, using the field's reservoir model, together with geochemical information (SO{sub 4}{sup 2}, Mg{sup 2+} K{sup +}, Ba{sup 2+}, Sr{sup 2+}, Ca{sup 2+}, Cl{sup -} concentrations) from the field's producers. From the data-set we show that some of the ions behave almost as ideal sea-water tracers, i.e. without sorption to the matrix, ion-exchange with the matrix or scale-formation with other ions in the formation water. Moreover, the dataset shows that ion concentrations in pure formation-water vary according to formation. This information can be used to allocate produced water to specific water-producing zones in commingled production. Based on an evaluation of the applicability of the available data, one inorganic component, SO{sub 4}{sup 2}, is used as a natural seawater tracer. Introducing SO{sub 4}{sup 2} as a natural tracer in a tracer simulation has revealed a potential for improvements of the reservoir model. By tracking the injected seawater it was possible to identify underestimated fault lengths in the reservoir model. The demonstration confirms that geochemical data are valuable additional information for reservoir characterization, and shows that integration of geochemical data into reservoir simulation procedures can improve reservoir simulation models. (author)

  18. A comparison of resting images from two myocardial perfusion tracers

    International Nuclear Information System (INIS)

    Anagnostopoulos, C.; Laney, R.; Pennell, D.; Proukakis, H.; Underwood, R.

    1995-01-01

    We have compared stress-redistribution and delayed rest thallium-201 with rest technetium-99m methoxyisobutylisonitrile (MIBI) tomograms in order to compare the tracers for the assessment of myocardial viability and to validate a rapid protocol combining the two tracers. We studied 30 consecutive patients with known or suspected coronary artery disease [group 1: 16 with normal left ventricular function, mean left ventricular ejection fraction (LVEF) 55%, SD 6%; group 2: 14 with abnormal function, mean LVEF 28%, SD 8%]. 201 Tl was injected during infusion of adenosine followed by acquisition of conventional stress and redistribution tomograms. On a separate day, 201 Tl was injected at rest with imaging 4 h later. 99m Tc-MIBI was then given at rest and imaging was performed. Three images were compared: redistribution 201 Tl, rest 201 Tl, and rest 99m Tc-MIBI. Tracer activity was classified visually and quantitatively in nine segments and segments with>50% activity were defined as containing clinically significant viable myocardium. Mean global tracer uptake as a percentage of maximum was similar in group 1 (rest 201 Tl 69%±12%, redistribution 201 Tl 69%±15%, rest 99m Tc-MIBI 70%±13%), but in group 2 mean tracer uptake was significantly greater in the rest 201 Tl images (59%±16%) than in redistribution 201 Tl images (53%±17%) or rest 99m Tc-MIBI images (53%±19%). Overall agreement for regional uptake score was excellent (κ from 0.79 to 0.84), although there were a significant number of segments with less uptake shown by redistribution 201 Tl and by rest 99m Tc-MIBI than by rest 201 Tl in group 2. The number of segments with significant viable myocardium in group 1 was very similar between the three images but in group 2 rest 201 Tl identified significantly more segments as viable than the other images. (orig./MG) (orig.). With 1 fig., 7 tabs

  19. Organic synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, S.E.

    1991-01-01

    This paper reports on reactions of organoboranes. Organoboron routes to unsaturated hydrocarbons. Boronic ester homologation. Properties of organosilicon compounds. Alkene synthesis (Peterson olefination). Allylsilanes and acylsilanes.

  20. [18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors

    International Nuclear Information System (INIS)

    Gruender, G.; Lange-Asschenfeldt, C.; Vernaleken, I.; Lueddens, H.; Siessmeier, T.; Buchholz, H.-G.; Bartenstein, P.; Stoeter, P.; Drzezga, A.; Roesch, F.

    2001-01-01

    5-(2'-[ 18 F]Fluoroethyl)flumazenil ([ 18 F]FEF) is a fluorine-18 labelled positron emission tomography (PET) tracer for central benzodiazepine receptors. Compared with the established [ 11 C]flumazenil, it has the advantage of the longer half-life of the fluorine-18 label. After optimisation of its synthesis and determination of its in vitro receptor affinities, we performed first PET studies in humans. PET studies in seven healthy human volunteers were performed on a Siemens ECAT EXACT whole-body scanner after injection of 100-280 MBq [ 18 F]FEF. In two subjects, a second PET scan was conducted after pretreatment with unlabelled flumazenil (1 mg or 2.5 mg i.v., 3 min before tracer injection). A third subject was studied both with [ 18 F]FEF and with [ 11 C]flumazenil. Brain radioactivity was measured for 60-90 min p.i. and analysed with a region of interest-oriented approach and on a voxelwise basis with spectral analysis. Plasma radioactivity was determined from arterial blood samples and metabolites were determined by high-performance liquid chromatography. In human brain, maximum radioactivity accumulation was observed 4±2 min p.i., with a fast clearance kinetics resulting in 50% and 20% of maximal activities at about 10 and 30 min, respectively. [ 18 F]FEF uptake followed the known central benzodiazepine receptor distribution in the human brain (occipital cortex >temporal cortex >cerebellum >thalamus >pons). Pretreatment with unlabelled flumazenil resulted in reduced tracer uptake in all brain areas except for receptor-free reference regions like the pons. Parametric images of distribution volume and binding potential generated on a voxelwise basis revealed two- to three-fold lower in vivo receptor binding of [ 18 F]FEF compared with [ 11 C]flumazenil, while relative uptake of [ 18 F]FEF was higher in the cerebellum, most likely owing to its relatively higher affinity for benzodiazepine receptors containing the α6 subunit. Metabolism of [ 18 F]FEF was very

  1. The Synthesis of 58co-Naphthenate Complex Compound for Evaluation of Oil well Production Capacity

    International Nuclear Information System (INIS)

    Duyeh Setiawan; Marlina

    2009-01-01

    The nuclear technique using radioisotope as a tracer in oil industry has assisted to solve the degradation of oil production. Usually, the degradation of oil production in well caused by the formation changing of hydrostatic pressure of the oil layer in the well. This problem could be evaluated by injection of water to oil well, for recovering this hydrostatic pressure. The watcher of the water injection success is done by the way of nuclear technique radioactive tracer systems, applied radioisotope having short half life and low gamma radiation energy. Radioisotope cobalt-58 in the complex form with naphthenate ( 58 Co-naphthenate ) often used as the tracer in the water injection technique. The tracer 58 Co-naphthenate relatively easy to synthesis and radioisotope 58 Co has half life 70.86 days and gamma energy was 0.811 Me v. The synthesis method of 58 Co-naphthenate route has been carried out by mixing of 58 CoCl 2 radioisotope solution with sodium naphthenate (C 5 H 9 CH 2 COONa) in the optimum condition. The results shows that the optimal mole ratio of cobalt-58 and naphthenate was 1:6 which produced 87,38 % of ren dement and 82,5 % of efficiency labelling. This synthesis technique was made permanent procedure for making of 58 Co-naphthenate complex as radioactive tracer in service of radioisotope production especially industrial area. (author)

  2. Inert tracer wind resuspension as a function of wind speed, atmospheric stability, and initial tracer particle size

    International Nuclear Information System (INIS)

    Sehmel, G.A.; Lloyd, F.D.

    1979-01-01

    Wind-caused resuspension rates are being determined in three different, long-term, inert-tracer field experiments. Chemical results were recently received from an accumulated backlog of air filter samples. Resuspension rates are yet to be calculated from these data

  3. Tracing freshwater nitrate sources in pre-alpine groundwater catchments using environmental tracers

    Science.gov (United States)

    Stoewer, M. M.; Knöller, K.; Stumpp, C.

    2015-05-01

    Groundwater is one of the main resources for drinking water. Its quality is still threatened by the widespread contaminant nitrate (NO3-). In order to manage groundwater resources in a sustainable manner, we need to find options of lowering nitrate input. Particularly, a comprehensive knowledge of nitrate sources is required in areas which are important current and future drinking water reservoirs such as pre-alpine aquifers covered with permanent grassland. The objective of the present study was to identify major sources of nitrate in groundwater with low mean nitrate concentrations (8 ± 2 mg/L). To achieve the objective, we used environmental tracer approaches in four pre-alpine groundwater catchments. The stable isotope composition and tritium content of water were used to study the hydrogeology and transit times. Furthermore, nitrate stable isotope methods were applied to trace nitrogen from its sources to groundwater. The results of the nitrate isotope analysis showed that groundwater nitrate was derived from nitrification of a variety of ammonium sources such as atmospheric deposition, mineral and organic fertilizers and soil organic matter. A direct influence of mineral fertilizer, atmospheric deposition and sewage was excluded. Since temporal variation in stable isotopes of nitrate were detected only in surface water and locally at one groundwater monitoring well, aquifers appeared to be well mixed and influenced by a continuous nitrate input mainly from soil derived nitrogen. Hydrogeological analysis supported that the investigated aquifers were less vulnerable to rapid impacts due to long average transit times, ranging from 5 to 21 years. Our study revealed the importance of combining environmental tracer approaches and a comprehensive sampling campaign (local sources of nitrate, soil water, river water, and groundwater) to identify the nitrate sources in groundwater and its vulnerability. In future, the achieved results will help develop targeted

  4. Low-cost, High Flexibility I-V Curve Tracer for Photovoltaic Modules

    DEFF Research Database (Denmark)

    Ibirriaga, Julen Joseba Maestro; Pena, Xabier Miquelez de Mendiluce; Opritescu, Adrian

    2010-01-01

    This work presents the design, construction and test of an in-door low cost, high flexibility I-V curve tracer for photovoltaic modules. The tracer is connected to a Xenon lamp based flashing solar simulator. The designed tracer is able to deal with the very fast changing irradiation conditions...

  5. Water Resources

    International Nuclear Information System (INIS)

    Abira, M.A.

    1997-01-01

    Water is essential for life and ecological sustenance; its availability is essential component of national welfare and productivity.The country's socio-economic activities are largely dependent on the natural endowment of water resources. Kenya's water resources comprises of surface waters (rivers, lakes and wetlands) and ground water. Surface water forms 86% of total water resources while the rest is ground water Geological, topographical and climatic factors influence the natural availability and distribution of water with the rainfall distribution having the major influence. Water resources in Kenya are continuously under threat of depletion and quality degradation owing to rising population, industrialization, changing land use and settlement activities as well as natural changes. However, the anticipated climate change is likely to exacerbate the situation resulting in increased conflict over water use rights in particular, and, natural resource utilisation in general. The impacts of climate change on the water resources would lead to other impacts on environmental and socio-economic systems

  6. A multi-tracer approach to delineate groundwater dynamics in the Rio Actopan Basin, Veracruz State, Mexico

    Science.gov (United States)

    Pérez Quezadas, Juan; Heilweil, Victor M.; Cortés Silva, Alejandra; Araguas, Luis; Salas Ortega, María del Rocío

    2016-12-01

    Geochemistry and environmental tracers were used to understand groundwater resources, recharge processes, and potential sources of contamination in the Rio Actopan Basin, Veracruz State, Mexico. Total dissolved solids are lower in wells and springs located in the basin uplands compared with those closer to the coast, likely associated with rock/water interaction. Geochemical results also indicate some saltwater intrusion near the coast and increased nitrate near urban centers. Stable isotopes show that precipitation is the source of recharge to the groundwater system. Interestingly, some high-elevation springs are more isotopically enriched than average annual precipitation at higher elevations, indicating preferential recharge during the drier but cooler winter months when evapotranspiration is reduced. In contrast, groundwater below 1,200 m elevation is more isotopically depleted than average precipitation, indicating recharge occurring at much higher elevation than the sampling site. Relatively cool recharge temperatures, derived from noble gas measurements at four sites (11-20 °C), also suggest higher elevation recharge. Environmental tracers indicate that groundwater residence time in the basin ranges from 12,000 years to modern. While this large range shows varying groundwater flowpaths and travel times, ages using different tracer methods (14C, 3H/3He, CFCs) were generally consistent. Comparing multiple tracers such as CFC-12 with CFC-113 indicates piston-flow to some discharge points, yet binary mixing of young and older groundwater at other points. In summary, groundwater within the Rio Actopan Basin watershed is relatively young (Holocene) and the majority of recharge occurs in the basin uplands and moves towards the coast.

  7. Daily Migraine Prevention and Its Influence on Resource Utilization in the Military Health System

    Science.gov (United States)

    2006-08-01

    Connection Between Prevention and Resource Use .....................17 Synthesis of Literature Review...Utilization ..................................26 Treatment Evaluation with Observational Designs .........................31 Synthesis of Conceptual...amitriptyline atenolol cyproheptadine methysergide carbamazepine divalproex fluoxetine bupropion clomipramine propranolol gabapentin diltiazem

  8. Measuring Protein Synthesis Rate In Living Object Using Flooding Dose And Constant Infusion Methods

    OpenAIRE

    Ulyarti, Ulyarti

    2018-01-01

    Constant infusion is a method used for measuring protein synthesis rate in living object which uses low concentration of amino acid tracers. Flooding dose method is another technique used to measure the rate of protein synthesis which uses labelled amino acid together with large amount of unlabelled amino acid.  The latter method was firstly developed to solve the problem in determination of precursor pool arise from constant infusion method.  The objective of this writing is to com...

  9. Potential tracers for tracking septic tank effluent discharges in watercourses.

    Science.gov (United States)

    Richards, Samia; Withers, Paul J A; Paterson, Eric; McRoberts, Colin W; Stutter, Marc

    2017-09-01

    Septic tank effluent (STE) contributes to catchment nutrient and pollutant loads. To assess the role of STE discharges in impairment of surface water, it is essential to identify the sources of pollution by tracing contaminants in watercourses. We examined tracers that were present in STE to establish their potential for identifying STE contamination in two stream systems (low and high dilution levels) against the background of upstream sources. The studied tracers were microbial, organic matter fluorescence, caffeine, artificial sweeteners and effluent chemical concentrations. The results revealed that tracer concentration ratios Cl/EC, Cl/NH 4 -N, Cl/TN, Cl/TSS, Cl/turbidity, Cl/total coliforms, Cl/sucralose, Cl/saccharin and Cl/Zn had potential as tracers in the stream with low dilution level (P < 0.05). Fluorescence spectroscopy could detect STE inputs through the presence of the tryptophan-like peak, but was limited to water courses with low level of dilution and was positively correlated with stream Escherichia coli (E. coli) and soluble reactive phosphorus (SRP). The results also suggested that caffeine and artificial sweeteners can be suitable tracers for effluent discharge in streams with low and high level of dilution. Caffeine and saccharin were positively correlated with faecal coliforms, E. coli, total P and SRP, indicating their potential to trace discharge of a faecal origin and to be a marker for effluent P. Caffeine and SRP had similar attenuation behaviour in the receiving stream waters suggesting caffeine's potential role as a surrogate indicator for the behaviour of P downstream of effluent inputs. Taken together, results suggest that a single tracer alone was not sufficient to evaluate STE contamination of watercourses, but rather a combination of multiple chemical and physical tracing approaches should be employed. A multiple tracing approach would help to identify individual and cumulative STE inputs that pose risks to stream waters in

  10. Municipal Solid Waste Management: Recycling, Resource Recovery, and Landfills. LC Science Tracer Bullet.

    Science.gov (United States)

    Meikle, Teresa, Comp.

    Municipal solid waste refers to waste materials generated by residential, commercial, and institutional sources, and consists predominantly of paper, glass, metals, plastics, and food and yard waste. Within the definition of the Solid Waste Disposal Act, municipal solid waste does not include sewage sludge or hazardous waste. The three main…

  11. Strontium isotope geochemistry of alluvial groundwater: a tracer for groundwater resources characterisation

    Directory of Open Access Journals (Sweden)

    P. Négrel

    2004-01-01

    Full Text Available This study presents strontium isotope and major ion data of shallow groundwater and river water from the Ile du Chambon catchment, located on the Allier river in the Massif Central (France. There are large variations in the major-element contents in the surface- and groundwater. Plotting of Na vs. Cl contents and Ca, Mg, NO3, K, SO4, HCO3, Sr concentrations reflect water–rock interaction (carbonate dissolution for Ca, Mg, HCO3 and Sr because the bedrock contains marly limestones, agricultural input (farming and fertilising and sewage effluents (for NO3, K, SO4, although some water samples are unpolluted. Sr contents and isotope ratios (87Sr/86Sr vary from 0.70892 to 0.71180 along the hydrological cycle in the groundwater agree with previous work on groundwater in alluvial aquifers in the Loire catchment. The data plot along three directions in a 87Sr/86Sr v. 1/Sr diagram as a result of mixing, involving at least three geochemical signatures–Allier river water, and two distinct signatures that might be related to different water-rock interactions in the catchment. Mixing proportions are calculated and discussed. The alluvial aquifer of the Ile du Chambon catchment is considered, within the Sr isotope systematic, in a larger scheme that includes several alluvial aquifers of the Loire Allier catchment. Keywords: : Loire river, major and trace elements, Sr isotopic ratio, alluvial aquifer, hydrology

  12. Studies on the distribution of radioactivity in the organism and rate of incorporation of radioactivity into the tissue proteins of monogastric animals after intravenous injection of tracer amino acids

    International Nuclear Information System (INIS)

    Simon, O.; Muenchmeyer, R.; Bergner, H.; Zebrowska, T.

    1976-01-01

    Radioactive amino acids ( 14 C leucine and 3 H lysine) were administrated to pigs by means of a catheter tube into the jugular vein. Subsequently, the time pattern of the distribution of the specific amino acid radioactivity was followed in the TCE soluble and TCE precipitable fractions of the blood plasma (TCE = trichloroacetic acid). Rats were injected 14 C into the portal vein. The animals were killed after incorporation periods of 2 to 60 minutes, and the levels of specific radioactivity were estimated in the TCE soluble and TCE precipitable fractions of the blood plasma, in the liver and in the skeletal muscles. The experimental results indicated that the specific radioactivity of the tracer amino acids and the rate of incorporation of radioactivity into tissue proteins were influenced by the size of the free amino acid pool within the range of distribution of the tracer. An estimation of the magnitude of the pool of free amino acids within the distribution range of the tracer can be obtained from the curve pattern for the decline of specific radioactivity of the corresponding free amino acid in the blood plasma. This pool exhibits a high rate of turnover. In all studies made to evaluate in vivo processes of protein synthesis using radioactive tracer amino acids it will be particularly important that consideration is given to the specific radioactivity of the amino acid in the precursor pool for protein synthesis. (author)

  13. A monitoring system of radioactive tracers in hydroponic solution for research on plant physiology

    International Nuclear Information System (INIS)

    Suzui, N.; Kawachi, N.; Ishioka, N.; Fujimaki, S.; Yamaguchi, M.

    2009-01-01

    The mechanism of nutrient uptake in plants has received considerable attention in the field of plant science. Here we describe the development of a new monitoring system of radioactive tracers in hydroponic solution, which enables the noninvasive measurement of radioactive tracer uptake by an intact plant. In addition, we incorporated a weighing instrument into this system in order to simultaneously monitor water uptake by the same plant. For an evaluation of this monitoring system, we conducted a tracer experiment with a rice plant and a positron-emitting radioactive tracer, and successfully obtained continuous data for the amounts of radioactive tracer and water taken up by the intact plant over 36 h. (authors)

  14. A monitoring system of radioactive tracers in hydroponic solution for research on plant physiology

    Energy Technology Data Exchange (ETDEWEB)

    Suzui, N.; Kawachi, N.; Ishioka, N.; Fujimaki, S. [Quantum Beam Science Directorate, Japan Atomic Energy Agency, Takasaki, Gunma 370-1292 (Japan); Yamaguchi, M. [Takasaki Advanced Radiation Research Institute, Atomic Energy Agency, Takasaki, Gunma 370-1292 (Japan)

    2009-07-01

    The mechanism of nutrient uptake in plants has received considerable attention in the field of plant science. Here we describe the development of a new monitoring system of radioactive tracers in hydroponic solution, which enables the noninvasive measurement of radioactive tracer uptake by an intact plant. In addition, we incorporated a weighing instrument into this system in order to simultaneously monitor water uptake by the same plant. For an evaluation of this monitoring system, we conducted a tracer experiment with a rice plant and a positron-emitting radioactive tracer, and successfully obtained continuous data for the amounts of radioactive tracer and water taken up by the intact plant over 36 h. (authors)

  15. De Novo Glutamine Synthesis

    Science.gov (United States)

    He, Qiao; Shi, Xinchong; Zhang, Linqi; Yi, Chang; Zhang, Xuezhen

    2016-01-01

    Purpose: The aim of this study was to investigate the role of de novo glutamine (Gln) synthesis in the proliferation of C6 glioma cells and its detection with 13N-ammonia. Methods: Chronic Gln-deprived C6 glioma (0.06C6) cells were established. The proliferation rates of C6 and 0.06C6 cells were measured under the conditions of Gln deprivation along with or without the addition of ammonia or glutamine synthetase (GS) inhibitor. 13N-ammonia uptake was assessed in C6 cells by gamma counting and in rats with C6 and 0.06C6 xenografts by micro–positron emission tomography (PET) scanning. The expression of GS in C6 cells and xenografts was assessed by Western blotting and immunohistochemistry, respectively. Results: The Gln-deprived C6 cells showed decreased proliferation ability but had a significant increase in GS expression. Furthermore, we found that low concentration of ammonia was sufficient to maintain the proliferation of Gln-deprived C6 cells, and 13N-ammonia uptake in C6 cells showed Gln-dependent decrease, whereas inhibition of GS markedly reduced the proliferation of C6 cells as well as the uptake of 13N-ammoina. Additionally, microPET/computed tomography exhibited that subcutaneous 0.06C6 xenografts had higher 13N-ammonia uptake and GS expression in contrast to C6 xenografts. Conclusion: De novo Gln synthesis through ammonia–glutamate reaction plays an important role in the proliferation of C6 cells. 13N-ammonia can be a potential metabolic PET tracer for Gln-dependent tumors. PMID:27118759

  16. Plasma glutamine is a minor precursor for the synthesis of citrulline: A multispecies study

    Science.gov (United States)

    Glutamine is considered the main precursor for citrulline synthesis in many species, including humans. The transfer of 15N from 2[15N]-glutamine to citrulline has been used as evidence for this precursor-product relationship. However, work in mice has shown that nitrogen and carbon tracers follow di...

  17. Brain tumors : L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate

    NARCIS (Netherlands)

    Pruim, J; Willemsen, A T; Molenaar, W M; Waarde, A van; Paans, A M; Heesters, M A; Go, K G; Visser, Gerben; Franssen, E J; Vaalburg, W

    1995-01-01

    PURPOSE: Positron emission tomography (PET) with the amino acid tracer L-[1-C-11]-tyrosine was evaluated in 27 patients with primary and recurrent brain tumors. MATERIALS AND METHODS: Patients underwent either static (n = 14) or dynamic PET (n = 13), with quantification of protein synthesis rate

  18. In-EDTA as activable tracer in hydrogeological investigations

    International Nuclear Information System (INIS)

    Stanescu, S.P.; Gaspar, E.; Spiridon, S.; Farcasiu, O.M.; Catilina, R.

    1982-12-01

    Two experiments are presented, on the possibilities of the use of indium in the form of the In-EDTA complex, as an activable tracer for hydrogeological studies. The determination of indium concentrations in the sampled water has been carried out by using the coprecipitation of indium with bismuth hydroxide, the neutron activation at the VVR-S reactor of the Institute for Nuclear Physics and Engineering - Bucharest and the measurement on the 417.0 keV line of sup(116m)In with the Ge(Li) spectrometric device. The advantages of the utilization of In-EDTA as a tracer for marking large volumes of water and of some long transit waters (of the order of months) have resulted. (authors)

  19. Contributions to hydrological tracer methods and their application

    International Nuclear Information System (INIS)

    1982-04-01

    The activities of the Institut fuer Radiohydrometrie of the GSF are mainly devoted to the field of environmental research studying the quality, use and protection from pollution of drinking water which has become scarce in many parts of the world. The knowledge and experience of a variety of scientific disciplines are combined to the common task of developing new tracer methods and selecting suitable hydrogeological methods to allow quantitative studies of the hydrological cycle, from rainfall to surface or sub-surface run-off. The tracers used in these studies are for the most part stable, natural radioisotopes occurring in the hydrological cycle, as well as fluorescent dyes or radionuclides for water labelling. The contributions collected in this volume are grouped according to the above outline of tasks and present a survey of current methods and measurements, illustrating their efficiency in solving hydrological problems. (orig./RW) [de

  20. Tracer Methods for Characterizing Fracture Creation in Engineered Geothermal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Peter [Energy & Geoscience Institute at the University of Utah, Salt Lake City, UT (United States); Harris, Joel [Univ. of Utah, Salt Lake City, UT (United States)

    2014-05-08

    The aim of this proposal is to develop, through novel high-temperature-tracing approaches, three technologies for characterizing fracture creation within Engineered Geothermal Systems (EGS). The objective of a first task is to identify, develop and demonstrate adsorbing tracers for characterizing interwell reservoir-rock surface areas and fracture spacing. The objective of a second task is to develop and demonstrate a methodology for measuring fracture surface areas adjacent to single wells. The objective of a third task is to design, fabricate and test an instrument that makes use of tracers for measuring fluid flow between newly created fractures and wellbores. In one method of deployment, it will be used to identify qualitatively which fractures were activated during a hydraulic stimulation experiment. In a second method of deployment, it will serve to measure quantitatively the rate of fluid flowing from one or more activated fracture during a production test following a hydraulic stimulation.

  1. Scintigraphy of inflammation with nanometer-sixed colloidal tracers

    International Nuclear Information System (INIS)

    De Schrijver, M.

    1989-01-01

    This book describes a novel approach to the scintigraphy of inflammatory processes of the extremities. It presents a method specially developed to bring this diagnostic modality whithin the reach of every nuclear medicine centre without requiring a special infrastructure or extensively trained personnel. The author revieuws the existing nuclear medicine techniques and critically analyses their relative advantages and pitfalls before proceeding to a detailed account of the use of a colloidal tracer for detecting and monitoring inflammation. The author identifies the pathophysiological basis of his concept and gives extensive preclinical data prior to discussing a number of comparative clinical studies with the new technique. Additional benefits are brought by the book's emphasis on the importance of a solid radiopharmacological foundation to the medically used tracers and demonstrates with a few suprising examples how shortcomings at this level may lead to misleading findings in the daily practive of nuclear medicine, even with routinely used radiopharmaceuticals. (author). refs.; figs.; tabs

  2. Focuss algorithm application in kinetic compartment modeling for PET tracer

    International Nuclear Information System (INIS)

    Huang Xinrui; Bao Shanglian

    2004-01-01

    Molecular imaging is in the process of becoming. Its application mostly depends on the molecular discovery process of imaging probes and drugs, from the mouse to the patient, from research to clinical practice. Positron emission tomography (PET) can non-invasively monitor . pharmacokinetic and functional processes of drugs in intact organisms at tracer concentrations by kinetic modeling. It has been known that for all biological systems, linear or nonlinear, if the system is injected by a tracer in a steady state, the distribution of the tracer follows the kinetics of a linear compartmental system, which has sums of exponential solutions. Based on the general compartmental description of the tracer's fate in vivo, we presented a novel kinetic modeling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET), which can determine a parsimonious model consisting with the measured data. This kinetic modeling technique allows for estimation of parametric images from a voxel based analysis and requires no a priori decision about the tracer's fate in vivo, instead determining the most appropriate model from the information contained within the kinetic data. Choosing a set of exponential functions, convolved with the plasma input function, as basis functions, the time activity curve of a region or a pixel can be written as a linear combination of the basis functions with corresponding coefficients. The number of non-zero coefficients returned corresponds to the model order which is related to the number of tissue compartments. The system macro parameters are simply determined using the focal underdetermined system solver (FOCUSS) algorithm. The FOCUSS algorithm is a nonparametric algorithm for finding localized energy solutions from limited data and is a recursive linear estimation procedure. FOCUSS algorithm usually converges very fast, so demands a few iterations. The effectiveness is verified by simulation and clinical

  3. Application of enriched stable isotopes as tracers in biological systems

    DEFF Research Database (Denmark)

    Stürup, Stefan; Hansen, Helle Rüsz; Gammelgaard, Bente

    2008-01-01

    The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry...... (ICP-MS) instrumentation, such as reaction/collision cell ICP-MS and multicollector ICP-MS with improved isotope ratio measurement and interference removal capabilities. Adaptation and refinement of radioisotope tracer experiment methodologies for enriched stable isotope experiments......, and the development of new methodologies coupled with more advanced compartmental and mathematical models for the distribution of elements in living organisms has enabled a broader use of enriched stable isotope experiments in the biological sciences. This review discusses the current and future uses of enriched...

  4. Delayed appearance of tracer lead in facial hair

    International Nuclear Information System (INIS)

    Rabinowitz, M.; Wetherill, G.; Kopple, J.

    1976-01-01

    Three adult men were fed 204 Pb--a rare, stable isotope of lead--daily for about 100 days. Simultaneous blood and facial hair measurements of this tracer and of total lead concentrations were made by mass spectrometric isotope dilution analysis. Although the blood showed an immediate response to the intake of the tracer, the facial hair showed a more gradual response and a delay of approximately 35 days. Since the pattern of appearance of lead in hair does not appear to represent a simple time delay of blood lead concentration, the existence of a physiological pool of lead fed by the blood and giving rise to the content in hair is suggested. Hair lead values should therefore, be interpreted as the integral of the blood lead values over the mean life of this intermediate pool--about 100 days

  5. In-situ fracture mapping using geotomography and brine tracers

    International Nuclear Information System (INIS)

    Deadrick, F.J.; Ramirez, A.L.; Lytle, R.J.

    1981-01-01

    The Lawrence Livermore National Laboratory is currently assessing the capabilities of high resolution geophysical methods to characterize geologic sites for the disposal of high level nuclear waste. A successful experiment has recently been performed in which salt water tracers and high frequency electromagnetic waves were utilized to map rock mass fracture zones in-situ. Multiple cross-borehole EM transmissions were used to generate a tomographic image of the fractured rock region between two boreholes. The tomographs obtained correlate well with conventional wireline geophysical logs which can be used to infer the location of fractured zones in the rock mass. This indirect data suggests that the geotomography and brine tracer technique may have merit in mapping fractured zones between boreholes

  6. Bromide as a tracer for studying water movement and nitrate displacement in soils: comparison with stable isotope tracers; Bromid als Tracer zur Untersuchung der Wasserbewegung und der Nitratverlagerung in Boeden: Vergleich mit stabilisotopen Tracern

    Energy Technology Data Exchange (ETDEWEB)

    Russow, R.; Knappe, S. [UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Bad Lauchstaedt (Germany). Sektion Bodenforschung

    1999-02-01

    Tracers are an ideal means of studying water movement and associated nitrate displacement. Often bromide is preferred as a tracer because it is considered a representative tracer for water and because, being a conservative tracer (i.e. not involved in chemical and biological soil processes), it can be used for studying anion transport in soils. Moreover, it is less expensive and easier to measure than the stable isotopes deuterium and {sup 15}N. Its great advantage over radioactive tracers (e.g. tritium), which outweighs their extreme sensitivity and ease of measurement and which it has in common with stable isotopes, is that it does not require radiation protection measures. However, there are also constraints on the use of bromide as a tracer in soil/water/plant systems. Our own studies on different soils using D{sub 2}O, bromide and [{sup 15}N]-nitrate in lysimeters suggest that the above assumptions on bromide tracers need not always be valid under conditions as they prevail in biologically active soils. As the present paper shows, these studies permit a good assessment of the possibilities and limits to these tracers. [Deutsch] Fuer die Untersuchung der Wasserbewegung sowie der daran gekoppelten Nitrat-Verlagerung ist der Einsatz von Tracern das Mittel der Wahl. Dabei wird Bromid als Tracer haeufig bevorzugt, da es allgemein als ein repraesentativer Tracer fuer Wasser und als konservativer Tracer (nicht involviert in chemische und biologische Bodenprozesse) zur Untersuchung des Anionentransportes in Boeden angesehen wird und es gegenueber den stabilen Isotopen Deuterium und {sup 15}N billiger und einfacher zu bestimmen ist. Gegenueber den radioaktiven Tracern (z.B. Tritium), die zwar sehr empfindlich und einfach messbar sind, besteht der grosse Vorteil, dass, wie bei den stabilen Isotopen, keine Strahlenschutzmassnahmen ergriffen werden muessen. Es gibt jedoch auch einschraenkende Hinweise fuer die Verwendung von Bromid als Tracer im System Boden

  7. Application of separable parameter space techniques to multi-tracer PET compartment modeling

    International Nuclear Information System (INIS)

    Zhang, Jeff L; Michael Morey, A; Kadrmas, Dan J

    2016-01-01

    Multi-tracer positron emission tomography (PET) can image two or more tracers in a single scan, characterizing multiple aspects of biological functions to provide new insights into many diseases. The technique uses dynamic imaging, resulting in time-activity curves that contain contributions from each tracer present. The process of separating and recovering separate images and/or imaging measures for each tracer requires the application of kinetic constraints, which are most commonly applied by fitting parallel compartment models for all tracers. Such multi-tracer compartment modeling presents challenging nonlinear fits in multiple dimensions. This work extends separable parameter space kinetic modeling techniques, previously developed for fitting single-tracer compartment models, to fitting multi-tracer compartment models. The multi-tracer compartment model solution equations were reformulated to maximally separate the linear and nonlinear aspects of the fitting problem, and separable least-squares techniques were applied to effectively reduce the dimensionality of the nonlinear fit. The benefits of the approach are then explored through a number of illustrative examples, including characterization of separable parameter space multi-tracer objective functions and demonstration of exhaustive search fits which guarantee the true global minimum to within arbitrary search precision. Iterative gradient-descent algorithms using Levenberg–Marquardt were also tested, demonstrating improved fitting speed and robustness as compared to corresponding fits using conventional model formulations. The proposed technique overcomes many of the challenges in fitting simultaneous multi-tracer PET compartment models. (paper)

  8. Quantifying postfire aeolian sediment transport using rare earth element tracers

    Science.gov (United States)

    Dukes, David; Gonzales, Howell B.; Ravi, Sujith; Grandstaff, David E.; Van Pelt, R. Scott; Li, Junran; Wang, Guan; Sankey, Joel B.

    2018-01-01

    Grasslands, which provide fundamental ecosystem services in many arid and semiarid regions of the world, are undergoing rapid increases in fire activity and are highly susceptible to postfire-accelerated soil erosion by wind. A quantitative assessment of physical processes that integrates fire-wind erosion feedbacks is therefore needed relative to vegetation change, soil biogeochemical cycling, air quality, and landscape evolution. We investigated the applicability of a novel tracer technique—the use of multiple rare earth elements (REE)—to quantify soil transport by wind and to identify sources and sinks of wind-blown sediments in both burned and unburned shrub-grass transition zone in the Chihuahuan Desert, NM, USA. Results indicate that the horizontal mass flux of wind-borne sediment increased approximately threefold following the fire. The REE tracer analysis of wind-borne sediments shows that the source of the horizontal mass flux in the unburned site was derived from bare microsites (88.5%), while in the burned site it was primarily sourced from shrub (42.3%) and bare (39.1%) microsites. Vegetated microsites which were predominantly sinks of aeolian sediments in the unburned areas became sediment sources following the fire. The burned areas showed a spatial homogenization of sediment tracers, highlighting a potential negative feedback on landscape heterogeneity induced by shrub encroachment into grasslands. Though fires are known to increase aeolian sediment transport, accompanying changes in the sources and sinks of wind-borne sediments may influence biogeochemical cycling and land degradation dynamics. Furthermore, our experiment demonstrated that REEs can be used as reliable tracers for field-scale aeolian studies.

  9. Development of in-vessel source term analysis code, tracer

    International Nuclear Information System (INIS)

    Miyagi, K.; Miyahara, S.

    1996-01-01

    Analyses of radionuclide transport in fuel failure accidents (generally referred to source terms) are considered to be important especially in the severe accident evaluation. The TRACER code has been developed to realistically predict the time dependent behavior of FPs and aerosols within the primary cooling system for wide range of fuel failure events. This paper presents the model description, results of validation study, the recent model advancement status of the code, and results of check out calculations under reactor conditions. (author)

  10. Tracer studies of flotation in laboratory and plant

    International Nuclear Information System (INIS)

    Niemi, A.J.; Thereska, J.; Plasari, E.; Kacaj, M.

    1992-01-01

    Froth flotation is used for the industrial extraction of valuable minerals from ores. Its progress depends on the properties of minerals being processed and on flotation practices. While flotation is basically a kinetic process, it functions industrially in continuous flow vessels whose flow patterns influence the separation effected. Radioisotope tracers have proven to be a necessary tool in the acquisition of both kinetic and flow pattern data

  11. Tracer investigations of macroprocesses in mineral processing. 1

    International Nuclear Information System (INIS)

    Koch, P.

    1981-01-01

    Results obtained from tracer studies in mineral processing have been evaluated with regard to the effects of hydrodynamic and design parameters of the single cell on flotation kinetics, to the residence time in single and in series-connected cells, and to the possibility of designing process control models. An algorithm is given for technological interpretation of results obtained from residence time and process kinetics studies

  12. PC-based hardware and software for tracer measurements

    International Nuclear Information System (INIS)

    Kaemaeraeinen, V.J.; Kall, Leif; Kaeki, Arvo

    1990-01-01

    Cheap, efficient personal computers can be used for both measurement and analysis. The results can be calculated immediately after the measurements are made in order to exploit the real-time measuring capabilities of tracer techniques fully. In the analysis phase the measurement information is visualized using graphical methods. The programs are menu drive to make them easy to use and adaptable for field conditions. The measuring equipment is modular for easy installation and maintenance. (author)

  13. Hanford facilities tracer study report (315 Water Treatment Facility)

    International Nuclear Information System (INIS)

    Ambalam, T.

    1995-01-01

    This report presents the results and findings of a tracer study to determine contact time for the disinfection process of 315 Water Treatment Facility that supplies sanitary water for the 300 Area. The study utilized fluoride as the tracer and contact times were determined for two flow rates. Interpolation of data and short circuiting effects are also discussed. The 315 Water Treatment Facility supplies sanitary water for the 300 Area to various process and domestic users. The Surface Water Treatment Rule (SWTR), outlined in the 1986 Safe Drinking Water Act Amendments enacted by the EPA in 1989 and regulated by the Washington State Department of Health (DOH) in Section 246-290-600 of the Washington Administrative Code (WAC), stipulates filtration and disinfection requirements for public water systems under the direct influence of surface water. The SWTR disinfection guidelines require that each treatment system achieves predetermined inactivation ratios. The inactivation by disinfection is approximated with a measure called CxT, where C is the disinfectant residual concentration and T is the effective contact time of the water with the disinfectant. The CxT calculations for the Hanford water treatment plants were derived from the total volume of the contact basin(s). In the absence of empirical data to support CxT calculations, the DOH determined that the CxT values used in the monthly reports for the water treatment plants on the Hanford site were invalid and required the performance of a tracer study at each plant. In response to that determination, a tracer study will be performed to determine the actual contact times of the facilities for the CxT calculations

  14. Radioisotope tracer study in an aniline production reactor

    International Nuclear Information System (INIS)

    Pant, H.J.; Yelgoankar, V.N.; Mendhekar, G.N.

    1995-01-01

    A radioisotope tracer study was carried out in an aniline production reactor to investigate the cause of poor heat transfer from tube side to shell side in an aniline production (ANPO) reactor. The results of the study indicated that more than 50% of the shell volume was reduced due to deposition of the process material (i.e. fouling) on the shell walls and may be the cause of poor heat transfer in the reactor. (author). 2 refs., 2 figs

  15. Hanford 100-N Area Tracer Study Final Report

    International Nuclear Information System (INIS)

    Kretzschmar, S.P.; Bedi, G.S.; Martinez, P.; Ervin, K.

    1996-09-01

    This document provides an engineering tracer study final report for the determination of contact time for the disinfection process at Group A Nontransient Noncommunity water treatment plant for the 100- N Water Plant (located on the Hanford Site in Richland, Washington). The purpose of this study is to determine the actual detention time within the plant clearwell, and the disinfection contact time at several clearwell effluent flow rates

  16. The importance of tracer technology in combined borehole investigations

    International Nuclear Information System (INIS)

    Zojer, H.

    1998-01-01

    In an experimental field for a waste disposal site, investigations have been carried out applying methods from geology, hydrology hydrogeology, hydrochemistry, environmental isotope hydrology and tracer technology. All data obtained result to a dynamic drainage model of groundwater. The combined interpretation of borehole data guarantees a high-grade knowledge of groundwater exfiltrating to the surface drainage, which enables proper control measures of the disposal site and an effective groundwater protection. (author)

  17. Modelling tracer transport in fractured rock at Stripa

    International Nuclear Information System (INIS)

    Herbert, A.

    1992-01-01

    We present the results of a modelling study, making predictions for tracer transport experiments carried out within the H-zone feature in the Stripa mine. We use a direct fracture network approach to represent the system of interconnected flow-conducting fractures comprising this zone. It is a highly fractured granite, and our fracture-network models include up to 60000 fractures. We have had to develop efficient algorithms to calculate the flow and transport through these networks; these techniques are described and justified. The first stage of modelling addressed two saline injection experiments. The results of these were known to us and so in addition to 'predicting' the results of these experiments, we used them to calibrate a flow model of the experimental site. This model was then used to make true 'blind' predictions for a set of tracer experiments carried out in the natural head-field, caused by an open drift. Where our flow model was good, our predictions were found to be very accurate, explaining the dispersion in the tracer breakthrough in terms of the fracture network geometry. Discrepancies for experiments in less well characterised regions of the H-zone are presented, and we suggest that the errors in these predictions are a consequence of the inaccuracies of the flow-field. We have demonstrated the use of large-scale fracture network modelling. It has proved very successful, and made very accurate predictions of field experiments carried out at the Stripa mine. The measured dispersion of tracers can be accounted for by the geometry of the fracture network flow system. (14 refs.) (au)

  18. Waste tank ventilation rates measured with a tracer gas method

    International Nuclear Information System (INIS)

    Huckaby, J.L.; Evans, J.C.; Sklarew, D.S.; Mitroshkov, A.V.

    1998-08-01

    Passive ventilation with the atmosphere is used to prevent accumulation of waste gases and vapors in the headspaces of 132 of the 177 high-level radioactive waste Tanks at the Hanford Site in Southeastern Washington State. Measurements of the passive ventilation rates are needed for the resolution of two key safety issues associated with the rates of flammable gas production and accumulation and the rates at which organic salt-nitrate salt mixtures dry out. Direct measurement of passive ventilation rates using mass flow meters is not feasible because ventilation occurs va multiple pathways to the atmosphere (i.e., via the filtered breather riser and unsealed tank risers and pits), as well as via underground connections to other tanks, junction boxes, and inactive ventilation systems. The tracer gas method discussed in this report provides a direct measurement of the rate at which gases are removed by ventilation and an indirect measurement of the ventilation rate. The tracer gas behaves as a surrogate of the waste-generated gases, but it is only diminished via ventilation, whereas the waste gases are continuously released by the waste and may be subject to depletion mechanisms other than ventilation. The fiscal year 1998 tracer studies provide new evidence that significant exchange of air occurs between tanks via the underground cascade pipes. Most of the single-shell waste tanks are connected via 7.6-cm diameter cascade pipes to one or two adjacent tanks. Tracer gas studies of the Tank U-102/U-103 system indicated that the ventilation occurring via the cascade line could be a significant fraction of the total ventilation. In this two-tank cascade, air evidently flowed from Tank U-103 to Tank U-102 for a time and then was observed to flow from Tank U-102 to Tank U-103

  19. PET and SPET tracers for mapping the cardiac nervous system

    International Nuclear Information System (INIS)

    Langer, Oliver; Halldin, Christer

    2002-01-01

    The human cardiac nervous system consists of a sympathetic and a parasympathetic branch with (-)-norepinephrine and acetylcholine as the respective endogenous neurotransmitters. Dysfunction of the cardiac nervous system is implicated in various types of cardiac disease, such as heart failure, myocardial infarction and diabetic autonomic neuropathy. In vivo assessment of the distribution and function of cardiac sympathetic and parasympathetic neurones with positron emission tomography (PET) and single-photon emission tomography (SPET) can be achieved by means of a number of carbon-11-, fluorine-18-, bromine-76- and iodine-123-labelled tracer molecules. Available tracers for mapping sympathetic neurones can be divided into radiolabelled catecholamines, such as 6-[ 18 F]fluorodopamine, (-)-6-[ 18 F]fluoronorepinephrine and (-)-[ 11 C]epinephrine, and radiolabelled catecholamine analogues, such as [ 123 I]meta-iodobenzylguanidine, [ 11 C]meta-hydroxyephedrine, [ 18 F]fluorometaraminol, [ 11 C]phenylephrine and meta-[ 76 Br]bromobenzylguanidine. Resistance to metabolism by monoamine oxidase and catechol-O-methyl transferase simplifies the myocardial kinetics of the second group. Both groups of compounds are excellent agents for an overall assessment of sympathetic innervation. Biomathematical modelling of tracer kinetics is complicated by the complexity of the steps governing neuronal uptake, retention and release of these agents as well as by their high neuronal affinity, which leads to partial flow dependence of uptake. Mapping of cardiac parasympathetic neurones is limited by a low density and focal distribution pattern of these neurones in myocardium. Available tracers are derivatives of vesamicol, a molecule that binds to a receptor associated with the vesicular acetylcholine transporter. Compounds like (-)-[ 18 F]fluoroethoxybenzovesamicol display a high degree of non-specific binding in myocardium which restricts their utility for cardiac neuronal imaging. (orig.)

  20. Radon as tracer to identify discharge sections at Juatuba basin

    International Nuclear Information System (INIS)

    Chagas, Claudio Jose; Ferreira, Vinicius Verna Magalhaes; Fonseca, Raquel Luisa Mageste; Rocha, Zildete; Moreira, Rubens Martins; Lemos, Nayron Cosme; Menezes, Angela de Barros Correia; Santos, Talita Oliveira

    2015-01-01

    The use of natural tracers in hydrological studies is a very useful tool, being applied in several studies. One of these tracers is the radon, 222 Rn, noble gas derived from natural sources, been found in all underground waters, as a product of radioactive decay of the 226 Ra. This gas can be found in the air, water, rocks or soil. In this paper, the 222 Rn detection in surface water was used as tracer in order to identify aquifer discharge sections in surface water at the Fundao stream, which belongs to the Juatuba river basin, through the second semester of 2014 and the first semester of 2015, in three sampling campaigns. The 222 Rn measurements at Fundao stream were carried out using the equipment RAD 7. The results showed that 222 Rn is present in some sections of the water course suggesting that there is a connection between groundwater and surface water. It also justifies the variation in the water level in the stream, recorded by a fluviometric station. (author)

  1. Radon as tracer to identify discharge sections at Juatuba basin

    Energy Technology Data Exchange (ETDEWEB)

    Chagas, Claudio Jose; Ferreira, Vinicius Verna Magalhaes; Fonseca, Raquel Luisa Mageste; Rocha, Zildete; Moreira, Rubens Martins; Lemos, Nayron Cosme; Menezes, Angela de Barros Correia, E-mail: vvmf@cdtn.br, E-mail: rlmf@cdtn.br, E-mail: cjc@cdtn.br, E-mail: rochaz@cdtn.br, E-mail: rubens@cdtn.br, E-mail: menezes@cdtn.br, E-mail: lemosnc@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Santos, Talita Oliveira, E-mail: talitaolsantos@yahoo.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Escola de Engenharia. Departamento de Engenharia Nuclear. Programa de Pos-Graduacao em Ciencias e Tecnicas Nucleares

    2015-07-01

    The use of natural tracers in hydrological studies is a very useful tool, being applied in several studies. One of these tracers is the radon, {sup 222}Rn, noble gas derived from natural sources, been found in all underground waters, as a product of radioactive decay of the {sup 226}Ra. This gas can be found in the air, water, rocks or soil. In this paper, the {sup 222}Rn detection in surface water was used as tracer in order to identify aquifer discharge sections in surface water at the Fundao stream, which belongs to the Juatuba river basin, through the second semester of 2014 and the first semester of 2015, in three sampling campaigns. The {sup 222}Rn measurements at Fundao stream were carried out using the equipment RAD 7. The results showed that {sup 222}Rn is present in some sections of the water course suggesting that there is a connection between groundwater and surface water. It also justifies the variation in the water level in the stream, recorded by a fluviometric station. (author)

  2. Tritium as tracer of flow in constructed wetlands

    International Nuclear Information System (INIS)

    Wachniew, P.; Czuprynski, P.; Maloszewski, P.

    2005-01-01

    Constructed wetlands technology is a cost-effective and environmentally friendly method used world-wide to treat waste waters of different origins. The soluble pollutants are transformed and removed mainly through the processes that occur at surfaces of plants, plant debris or filtering media. The efficiency of soluble pollutants removal is thus primarily related to the extent of contact between waste waters and the reactive surfaces. Residence time distributions function (RTD)is basic characteristic of wetland hydraulic properties and can be obtained by combined use of tracer technique and mathematical modelling. Tritium was used as to obtain RTD's of three parallel cells of a sub-surface flow constructed wetland overgrown with Pharagmites australis in Nowa Slupia. Tritium as a part of water molecule, is an ideal tracer of flow in the highly reactive environment of constructed wetlands. Results of the tracer test interpreted by the assumed model (Multi Flow Dispersion Model) of conservative solute transport revealed a complex structure of flow through the wetland. (author)

  3. Radiolabeled cypoxic cell sensitizers: tracer for assessment of ischemia

    International Nuclear Information System (INIS)

    Mathias, C.J.; Welch, M.J.; Kilbourn, M.R.; Jerabek, P.A.; Patrick, T.B.; Raichle, M.E.; Krohn, K.A.; Rasey, J.S.; Shaw, D.W.

    1987-01-01

    Hypoxic, non-functional, but viable, tissue may exist in heart and brain following an arterial occlusion. Identification of such tissue in vivo is crucial to the development of effective treatment strategies. It has been suggested that certain compounds capable of sensitizing hypoxic tumor cells to killing by x-rays (i.e., misonidazole) might serve as in vivo markers of hypoxic tissue in ischemic myocardium or brain if properly radiolabeled. To this end the authors have radiolabeled two fluorinated analogs of nitroimidazole based hypoxic cell sensitizers with the 110 minute half-lived positron-emitting fluorine-18. The ability of these tracers to quantitate the presence of hypoxic tissue has been studied in a gerbil stroke model. The in vivo uptake of one of these tracers [F-18]-fluoronormethyoxymisonidazole is dependent on the extent of tissue hypoxia, and thus, appears to have potential as a diagnostic indicator of non-functional but viable tissue when the tracer is used in conjunction with positron emission tomography. 80 references, 2 figures, 1 table

  4. Discrete fracture modelling for the Stripa tracer validation experiment predictions

    International Nuclear Information System (INIS)

    Dershowitz, W.; Wallmann, P.

    1992-02-01

    Groundwater flow and transport through three-dimensional networks of discrete fractures was modeled to predict the recovery of tracer from tracer injection experiments conducted during phase 3 of the Stripa site characterization and validation protect. Predictions were made on the basis of an updated version of the site scale discrete fracture conceptual model used for flow predictions and preliminary transport modelling. In this model, individual fractures were treated as stochastic features described by probability distributions of geometric and hydrologic properties. Fractures were divided into three populations: Fractures in fracture zones near the drift, non-fracture zone fractures within 31 m of the drift, and fractures in fracture zones over 31 meters from the drift axis. Fractures outside fracture zones are not modelled beyond 31 meters from the drift axis. Transport predictions were produced using the FracMan discrete fracture modelling package for each of five tracer experiments. Output was produced in the seven formats specified by the Stripa task force on fracture flow modelling. (au)

  5. Five channel data acquisition system for tracer studies

    International Nuclear Information System (INIS)

    Narender Reddy, J.; Dhananjay Reddy, Y.; Dheeraj Reddy, J.

    2001-01-01

    Radioactive tracers are being used by many modern industries for trouble shooting, process control/quality control and optimization in the process plants. A five channel data acquisition system which has five independent scintillation detector based channels for data acquisition has been developed and made available. This system can be used for tracer studies involving Mean residence time, Resident time distribution and other similar parameters involving tracer movement. System developed can acquire data with dwell times ranging from 10 m sec to 100 sec into each channel and has a capacity to acquire data into 10K channels. Each channel electronics, has a 1x1 NaI Scintillation Detector probe, HV, AMP SCA, micro-controller based data acquisition card with independent dot matrix LCD display for visualization. Extensive use of serial bus (I 2 C, microwire) compatible devices has been incorporated in the design. Data acquisition is initiated simultaneously into all the channels. System design permits delayed/prompt data acquisition selectively. Dual counter switching technique has been employed to achieve faster dwell times for data acquisition. (author)

  6. Quantitative measurement of maritime sediment movement using radioactive tracers

    International Nuclear Information System (INIS)

    Makovski, E.; Grissener, G.

    1967-01-01

    The quantitative method described in the paper involves burying appropriate detectors over a given area of the sea bottom, the detectors being connected to recording equipment which is itself buried in the sediment or situated on the shore. Detectors arranged in this way are covered by a certain layer of radioactive sediment whose activity is proportional to its mass. Before the labelled sediments are removed, their initial activity is measured, and then, as the covering is removed, measurements are made of the gradual decrease in activity corresponding to loss of the surface layer of the bottom deposit area under investigation, expressed in g/cm 2 . The tracers used in the investigations discussed were natural ones such as sea with 31 Si and artificial ones such as activated fragments of sodium glass (with a 6.5% admixture of Fe 2 O 3 ) with 24 Na . The proportional dependence of activity on mass has been confirmed for both tracers; this is an essential point for a tracer intended for quantitative measurements. This proportionality is very well maintained if a sample of highly active sediment is introduced into a large mass of inactive sediments (10 -2 - 10 -3 ). The concluding section describes the advantages of this method as a possible way of using radioisotopes with a short half-life and a low total activity of the order of a few millicuries. (author)

  7. Use of Helium-3 and Tritium tracers in oceanography

    International Nuclear Information System (INIS)

    Andrie, Chantal

    1987-01-01

    As tritium considered as a transient tracer has become one of the most promising tool for the study of oceanic circulation and of the ocean capacity to absorb anthropogenic carbon, and as the simultaneous use of its radioactive descendant, Helium-3, brings an additional information (together, these tracers build up a clock in the study of water masses), and as all helium-3 and tritium measurements are made by mass spectroscopy, this research thesis addresses the analytical process, the detection limit, and the method reproducibility associated with this use of both tracers. The author reports and discusses helium-3 data obtained during a measurement campaign which allowed the localisation of an active source and the evidence of an intermediate back current, and tritium data obtained during another measurement campaign which allowed the description of the high time variability of convection processes, and an assessment of water renewal delays and of some deep water circulations. He also reports and discusses the simultaneous use of helium-3 data and tritium data to localize areas where convection processes occur. A theoretical approach to this simultaneous use is proposed which uses a mixing model which distinguishes the venting transit time. Measurement campaigns were performed in Red Sea, western Mediterranean Sea, and north-eastern Atlantic Ocean [fr

  8. Robotic synthesis of L-[1-11C]tyrosine

    International Nuclear Information System (INIS)

    Luurtsema, Gert; Medema, Jitze; Elsinga, P.H.; Visser, G.M.; Vaalburg, Willem

    1994-01-01

    L-[1- 11 C]tyrosine promises to become an important tracer for determination of the protein synthesis rate (PSR) in tumor tissue and brain. The commercially available Anatech RB-86 robotic system is utilized for the automation of the L-[1- 11 C]tyrosine production via the isocyanide method as reported by Bolster et al. (Eur. J. Nucl. Med. 12, 321-324, 1986). The total synthesis time, including HPLC-purification and enantiomeric separation is 60 min. With a practical yield of 20 mCi L-[1- 11 C]tyrosine at a specific activity > 1000 Ci/mmol. (author)

  9. Fuels planning: science synthesis and integration; fact sheet: The Fuels Synthesis Project overview

    Science.gov (United States)

    Rocky Mountain Research Station USDA Forest Service

    2004-01-01

    The geographic focus of the "Fuels Planning: Science Synthesis and Integration" project #known as the Fuels Synthesis Project# is on the dry forests of the Western United States. Target audiences include fuels management specialists, resource specialists, National Environmental Policy Act #NEPA# planning team leaders, line officers in the USDA Forest Service...

  10. Interpretation of Water Tracer Simulation in the H-1 Segment of the Gullfaks Field

    Energy Technology Data Exchange (ETDEWEB)

    Moid, Farrukh

    2000-07-01

    This thesis describes the water tracer simulation in the H-1 segment of the Gullfaks field. Three passive water tracer slugs were injected from the two producing wells during water flooding, pressure maintenance and reservoir monitoring program in the Gullfaks field. The same program is considered in this thesis. Computer Modelling Group's (CMG) simulator STARS is used for the general reservoir simulation and a separate module for tracer flow (ITRC-SIM) which is incorporated in the STARS and developed at Institute For Energy (IFE) is used for the tracer simulation. Water cut and tracer concentration data are used in history matching of the field. History matching is performed by changing the transmissibility and permeability of different layers; also the effect of changing saturations near the well bore on history matching is examined. It is noted that water cut is sensitive to transmissibility of the layers and the saturation around the well bore. Tracers are found to be moving in the most permeable layers. The corresponding history matching of water and tracer production shows a severe loss of first tracer injected because of imbibition process. Water phase velocity and areal communication between different wells are determined. Advance numerical features of tracer module ITRC-SIM such as flux limiting scheme and grid refinement scheme are evaluated and are found to be an important tool for reducing the numerical smearing. The effects of dispersion and diffusion on tracer response curve are also evaluated. Dispersion makes the tracer concentration curve smeared. Simulation results of water cut and tracer concentration show a good history match for this reservoir. The improved simulation model and the tracer module for this reservoir can be used for the prediction of future performance of the reservoir and interpretation of the tracer behaviour in the reservoir. (author)

  11. Organic synthesis

    International Nuclear Information System (INIS)

    Lallemand, J.Y.; Fetizon, M.

    1988-01-01

    The 1988 progress report of the Organic Synthesis Chemistry laboratory (Polytechnic School, France), is presented. The laboratory activities are centered on the chemistry of natural products, which have a biological activity and on the development of new reactions, useful in the organic synthesis. The research works involve the following domains: the natural products chemistry which are applied in pharmacology, the plants and insects chemistry, the organic synthesis, the radical chemistry new reactions and the bio-organic physicochemistry. The published papers, the congress communications and the thesis are listed [fr

  12. Uranium resources

    International Nuclear Information System (INIS)

    Gangloff, A.

    1978-01-01

    It is first indicated how to evaluate the mining resources as a function of the cost of production and the degree of certainty in the knowledge of the deposit. A table is given of the world resources (at the beginning 1977) and resources and reserves are compared. There is a concordance between requirements and possible production until 1990. The case of France is examined: known reserves, present and future prospection, present production (In 1978 2200 T of U metal will be produced from 3 French processing plants), production coming from Cogema. A total production of 2000 T in 1980 and 10.000 in 1985 is expected [fr

  13. Process Analysis in Chemical Plant by Means of Radioactive Tracers

    Energy Technology Data Exchange (ETDEWEB)

    Hirayama, T.; Hamada, K.; Osada, K. [Showa Denko K.K., Tokyo (Japan)

    1967-06-15

    Following the movement of solids and fluids is important in chemical processes to determine mixing efficiency and residence time. Since it is necessary to follow many complex substances such as raw materials, intermediates and reactants in plant investigations, it is often necessary to ascertain whether the behaviour of the radioisotope tracer and the substance to be traced are identical. The most difficult problem is to determine the best method of labelling, a factor which is a substantial key to the success of an experiment. Usually, there are three labelling techniques: radioisotope labelling, pre-.activation of the material and post-activation of the material. This paper deals with practical examples of the double-tracer technique, a combination of conventional radioisotope labelling and post-activation methods by means of activation analysis. In process analysis by means of tracers, a practical measurement method should also be devised and developed for each experiment. Phosphorus-32 and gold (non-radioactive) were used to measure retention time in a carbon-black plant. The radioisotope was pumped into a feed-stock pipe positioned before the reactor and samples were taken from each process of the plant, including the bag filter, mixer and product tank. After sampling from each step of the process, {sup 32}P in a semi-infinite powder sample was measured in situ by beta counting, and the gold was measured by gamma counting after activating the sample in a reactor. The experiment showed that both tracers had the same residence time, which was shorter than expected. Useful data were also obtained from the dispersion pattern of the material flow for future operation controls, including the time required to change from one grade of product to another. Practical tracer techniques to measure mixing characteristics in high-speed gas flows using {sup 85}Kr have been developed. A study of the measurement method was conducted by calculating the differential values of

  14. Tracer experiment by using radioisotope in surface water environment

    International Nuclear Information System (INIS)

    Suh, K.S.; Kim, K.C.; Chun, I.Y.; Jung, S.H.; Lee, C.W.

    2007-01-01

    Complete text of publication follows. 1. Objective An expansion of industrial activities and urbanization result in still increasing amount of pollutants discharged into surface water. Discharged pollutants in surface water have harmful effects on the ecology of a river system and human beings. Pollutants discharged into surface water is transported and dispersed under conditions characteristic to particular natural water receiver. Radiotracer method is a useful tool for monitoring the pollutant dispersion and description of mixing process taking place in natural streams. A tracer experiment using radioisotope was carried out to investigate the characteristics of a pollutant transport and a determination of the diffusion coefficients in a river system. 2. Methods The upper area of the Keum river was selected for the tracer experiment, which is located in a mid west of Korea. The measurements of the velocity and bathymetry before a tracer experiment were performed to select the sampling lines for a detection of the radioisotope. The radioisotope was instantaneously injected into a flow as a point source by an underwater glass-vial crusher. The detection was made with 60 2inch NaI(Tl) scintillation detectors at 3 transverse lines at a downstream position. The multi-channel data acquisition systems were used to collect and process the signals transmitted from the detectors. Two-dimensional numerical models were used to simulate the hydraulic parameters and the concentration distributions of the radioisotope injected into the river. 3. Results and Conclusion The calculated results such as velocity and concentrations were compared with the measured ones. The dispersion characteristics of the radioisotope were analyzed according to a variation of the flow rate, water level and diffusion coefficients. Also, the diffusion coefficients were calculated by using the measured concentrations and the coefficients obtained from the field experiment were compared with the ones

  15. Radioactive tracer studies of soil and litter arthropod food chains. Progress report, November 1, 1978-October 31, 1979

    International Nuclear Information System (INIS)

    Crossley, D.A. Jr.

    1979-01-01

    Research on soil and litter arthropod food chains, concerning measurement of nutrient flow using radioisotope techniques and investigations of the role of soil arthropods as regulators of the ecosystem-level processes of decomposition and mineralization of nutrients is described. Laboratory measurements of radiotracer turnover by predaceous macroarthropods are reported, as well as the status of research with microarthropod turnover of radioactive tracers. Implications of results are evaluated in context of current understanding of nutrient flows along arthropod food chains. The interactions of soil fauna and mycorrhizal fungi are also under investigation. Field work has been completed on granitic outcrop projects, and a synthesis of results is summarized. Input-output budgets revealed that granitic outcrop island ecosystems are essentially in balance as regards nutrient flows. The ecosystems showed a strong resistance component of stability, as opposed to resilience, following an applied chemical perturbation and a natural one

  16. Preparation of 19-iodocholestrol labelled with I-125 and its study as a 'tracer' of plasma lipoprotein

    International Nuclear Information System (INIS)

    Rodriquez Barquero, L.

    1988-01-01

    A technique of synthesis of the 19-iodocholesterol labelled with I-125, modified in some steps from other methods published previously, is described. We have obtained a product with high chemical (96%) and radiochemical (99,9%) purities. The yield was higher and the time necessary to prepare it was lower than other methods reported. The study of thermal and radiolytic stability showed that the 19-iodocholesterol-I-125 was not broken by autoradiolysis whereas the I-125 was separated from the molecule when the temperature was increased. The use of this 19-iodocholesterol-I-125 as a tracer of cholesterol of plasma lipoprotein showed some properties of LCAT and CETP and also showed the different capacity of VLDL and LDL to transport cholesteryl esters. (author) 105 refs

  17. Radioactive tracer studies of soil and litter arthropod food chains. Progress report, November 1, 1978-October 31, 1979

    Energy Technology Data Exchange (ETDEWEB)

    Crossley, Jr, D A

    1979-07-15

    Research on soil and litter arthropod food chains, concerning measurement of nutrient flow using radioisotope techniques and investigations of the role of soil arthropods as regulators of the ecosystem-level processes of decomposition and mineralization of nutrients is described. Laboratory measurements of radiotracer turnover by predaceous macroarthropods are reported, as well as the status of research with microarthropod turnover of radioactive tracers. Implications of results are evaluated in context of current understanding of nutrient flows along arthropod food chains. The interactions of soil fauna and mycorrhizal fungi are also under investigation. Field work has been completed on granitic outcrop projects, and a synthesis of results is summarized. Input-output budgets revealed that granitic outcrop island ecosystems are essentially in balance as regards nutrient flows. The ecosystems showed a strong resistance component of stability, as opposed to resilience, following an applied chemical perturbation and a natural one (drought).

  18. Seaweed resources

    Digital Repository Service at National Institute of Oceanography (India)

    Deshmukhe, G.V.; Dhargalkar, V.K.; Untawale, A.G.

    The chapter summarizes our present knowledge of the seaweed resources of the Indian Ocean region with regard to the phytogeographical distribution, composition, biomass, utilization, cultivation, conservation and management. The voluminous data...

  19. Arthritis - resources

    Science.gov (United States)

    Resources - arthritis ... The following organizations provide more information on arthritis : American Academy of Orthopaedic Surgeons -- orthoinfo.aaos.org/menus/arthritis.cfm Arthritis Foundation -- www.arthritis.org Centers for Disease Control and Prevention -- www. ...

  20. Mineral resources

    Digital Repository Service at National Institute of Oceanography (India)

    Valsangkar, A.B.

    (placers), biogenous (ooze, limestone) or chemogenous (phosphorites and polymetallic nodules) type. In recent years, hydrothermal deposits, cobalt crust and methane gas hydrates are considered as frontier resources. Their distribution depends upon proximity...

  1. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depression/ ...

  2. Hemophilia - resources

    Science.gov (United States)

    Resources - hemophilia ... The following organizations provide further information on hemophilia : Centers for Disease Control and Prevention -- www.cdc.gov/ncbddd/hemophilia/index.html National Heart, Lung, and Blood Institute -- www.nhlbi.nih.gov/ ...

  3. Diabetes - resources

    Science.gov (United States)

    Resources - diabetes ... The following sites provide further information on diabetes: American Diabetes Association -- www.diabetes.org Juvenile Diabetes Research Foundation International -- www.jdrf.org National Center for Chronic Disease Prevention and Health Promotion -- ...

  4. Forest Resources

    Energy Technology Data Exchange (ETDEWEB)

    None

    2016-06-01

    Forest biomass is an abundant biomass feedstock that complements the conventional forest use of wood for paper and wood materials. It may be utilized for bioenergy production, such as heat and electricity, as well as for biofuels and a variety of bioproducts, such as industrial chemicals, textiles, and other renewable materials. The resources within the 2016 Billion-Ton Report include primary forest resources, which are taken directly from timberland-only forests, removed from the land, and taken to the roadside.

  5. Evaluating Chemical Tracers in Suburban Groundwater as Indicators of Nitrate-Nitrogen Sources

    Science.gov (United States)

    Nitka, A.; DeVita, W. M.; McGinley, P.

    2015-12-01

    The CDC reports that over 15 million US households use private wells. These wells are vulnerable to contamination. One of the most common contaminants in private wells is nitrate. Nitrate has a health standard of 10 mg/L. This standard is set to prevent methemaglobinemia, or "blue baby" syndrome, in infants. In extreme cases it can affect breathing and heart function, and even lead to death. Elevated nitrate concentrations have also been associated with increased risk of thyroid disease, diabetes, and certain types of cancer. Unlike municipal wells, there is no mandatory testing of private wells. It is the responsibility of users to have their well water tested. The objective of this research was to identify the most useful chemical tracers for determining sources of nitrate in private water supplies. Chemical characteristics, such as mobility in groundwater and water solubility, as well as frequency of use, were considered when choosing source indicators. Fourteen pharmaceuticals and personal care products unique to human use were chosen to identify wells impacted by septic waste. A bovine antibiotic and five pesticide metabolites were used to identify contamination from agricultural sources. Eighteen private wells were selected in a suburban area with septic systems and adjacent agricultural land. The wells were sampled five times and analyzed to provide a temporal profile of nitrate and the tracers. The artificial sweetener sucralose was found in >70% of private wells. Wells with sucralose detected had nitrate concentrations between 5-15 mg/L. The herbicide metabolite metolachlor ESA was detected in 50% of the wells. These wells typically had the highest nitrate concentrations, often >10 mg/L. The common use and frequent detection of these two compounds made them the most reliable indicators of nitrate sources evaluated in this study. This information will help well owners determine appropriate treatment and remediation options and could direct future

  6. Noble gas and hydrocarbon tracers in multiphase unconventional hydrocarbon systems: Toward integrated advanced reservoir simulators

    Science.gov (United States)

    Darrah, T.; Moortgat, J.; Poreda, R. J.; Muehlenbachs, K.; Whyte, C. J.

    2015-12-01

    Although hydrocarbon production from unconventional energy resources has increased dramatically in the last decade, total unconventional oil and gas recovery from black shales is still less than 25% and 9% of the totals in place, respectively. Further, the majority of increased hydrocarbon production results from increasing the lengths of laterals, the number of hydraulic fracturing stages, and the volume of consumptive water usage. These strategies all reduce the economic efficiency of hydrocarbon extraction. The poor recovery statistics result from an insufficient understanding of some of the key physical processes in complex, organic-rich, low porosity formations (e.g., phase behavior, fluid-rock interactions, and flow mechanisms at nano-scale confinement and the role of natural fractures and faults as conduits for flow). Noble gases and other hydrocarbon tracers are capably of recording subsurface fluid-rock interactions on a variety of geological scales (micro-, meso-, to macro-scale) and provide analogs for the movement of hydrocarbons in the subsurface. As such geochemical data enrich the input for the numerical modeling of multi-phase (e.g., oil, gas, and brine) fluid flow in highly heterogeneous, low permeability formations Herein we will present a combination of noble gas (He, Ne, Ar, Kr, and Xe abundances and isotope ratios) and molecular and isotopic hydrocarbon data from a geographically and geologically diverse set of unconventional hydrocarbon reservoirs in North America. Specifically, we will include data from the Marcellus, Utica, Barnett, Eagle Ford, formations and the Illinois basin. Our presentation will include geochemical and geological interpretation and our perspective on the first steps toward building an advanced reservoir simulator for tracer transport in multicomponent multiphase compositional flow (presented separately, in Moortgat et al., 2015).

  7. Application of fluorescent tracer agent technology to point-of-care gastrointestinal permeability measurement

    Science.gov (United States)

    Dorshow, Richard B.; Shieh, Jeng-Jong; Rogers, Thomas E.; Hall-Moore, Carla; Shaikh, Nurmohammad; Talcott, Michael; Tarr, Phillip I.

    2016-03-01

    Gut dysfunction, often accompanied by increased mucosal permeability to gut contents, frequently accompanies a variety of human intestinal inflammatory conditions. These disorders include inflammatory bowel diseases (e.g., Crohn's Disease) and environmental enteropathy and enteric dysfunction, a condition strongly associated with childhood malnutrition and stunting in resource poor areas of the world. The most widely used diagnostic assay for gastrointestinal permeability is the lactulose to mannitol ratio (L:M) measurement. These sugars are administered orally, differentially absorbed by the gut, and then cleared from the body by glomerular filtration in the kidney. The amount of each sugar excreted in the urine is measured. The larger sugar, lactulose, is minimally absorbed through a healthy gut. The smaller sugar, mannitol, in contrast, is readily absorbed through both a healthy and injured gut. Thus a higher ratio of lactulose to mannitol reflects increased intestinal permeability. However, several issues prevent widespread use of the L:M ratio in clinical practice. Urine needs to be collected over time intervals of several hours, the specimen then needs to be transported to an analytical laboratory, and sophisticated equipment is required to measure the concentration of each sugar in the urine. In this presentation we show that fluorescent tracer agents with molecular weights similar to those of the sugars, selected from our portfolio of biocompatible renally cleared fluorophores, mimic the L:M ratio test for gut permeability. This fluorescent tracer agent detection technology can be used to overcome the limitations of the L:M assay, and is amenable to point-of-care clinical use.

  8. Measuring serotonin synthesis : From conventional methods to PET tracers and their (pre)clinical implications

    NARCIS (Netherlands)

    Visser, Anniek K. D.; van Waarde, Aren; Willemsen, Antoon T. M.; Bosker, Fokko J.; Luiten, Paul G. M.; den Boer, Johan A.; Kema, Ido P.; Dierckx, Rudi A. J. O.

    The serotonergic system of the brain is complex, with an extensive innervation pattern covering all brain regions and endowed with at least 15 different receptors (each with their particular distribution patterns), specific reuptake mechanisms and synthetic processes. Many aspects of the functioning

  9. Journal: A Review of Some Tracer-Test Design Equations for ...

    Science.gov (United States)

    Determination of necessary tracer mass, initial sample-collection time, and subsequent sample-collection frequency are the three most difficult aspects to estimate for a proposed tracer test prior to conducting the tracer test. To facilitate tracer-mass estimation, 33 mass-estimation equations are reviewed here, 32 of which were evaluated using previously published tracer-test design examination parameters. Comparison of the results produced a wide range of estimated tracer mass, but no means is available by which one equation may be reasonably selected over the others. Each equation produces a simple approximation for tracer mass. Most of the equations are based primarily on estimates or measurements of discharge, transport distance, and suspected transport times. Although the basic field parameters commonly employed are appropriate for estimating tracer mass, the 33 equations are problematic in that they were all probably based on the original developers' experience in a particular field area and not necessarily on measured hydraulic parameters or solute-transport theory. Suggested sampling frequencies are typically based primarily on probable transport distance, but with little regard to expected travel times. This too is problematic in that tends to result in false negatives or data aliasing. Simulations from the recently developed efficient hydrologic tracer-test design methodology (EHTD) were compared with those obtained from 32 of the 33 published tracer-

  10. Development of activable tracers for application in secondary recovering in petroleum reservoirs

    International Nuclear Information System (INIS)

    Martins, Polyana Fabricia Fernandes; Moreira, Rubens Martins . Servico de Meio Ambiente e Tecnicas Nucleares.

    2007-01-01

    Nuclear methods are instrumental in describing detailed flow patterns and other features of oil reservoirs that are unattainable to other methods. Tracer studies in oil fields are performed in a net of injection and producing wells. Thus, the use of only one tracer species would not discriminate the contributions of distinct injection wells to the output of a given production well. Hence, a multi-tracer experiment is required, and the use of activable tracers, capable of being measured by neutron activation analysis (NAA) is here proposed. As additional tracer choices lanthanum (La) and europium (Eu) were chosen from the rare earth series due to their large neutron cross sections and general availability. In order to decrease losses to the oil phase and the retardation of the tracer relatively to the aqueous phase, these elements were complexed with organic chelating ligands: the polyaminocarboxylic acids EDTA, DTPA and DOTA. Infrared spectrometry was used to check complexation. In order to check the partition of the tracer between the aqueous and organic phases, tests were carried stirring the two phases together and measuring the tracer concentrations in the aqueous phase; the partition coefficient (Kao) was then calculated for all the combinations of the two lanthanides and the three ligands. Tests in which the tracer was continuously pumped through reservoir rock samples were also carried out using tritiated water as a reference tracer and the complexed lanthanides. (author)

  11. Tracer simulation using a global general circulation model: Results from a midlatitude instantaneous source experiment

    International Nuclear Information System (INIS)

    Mahlman, J.D.; Moxim, W.J.

    1978-01-01

    An 11-level general circulation model with seasonal variation is used to perform an experiment on the dispersion of passive tracers. Specially constructed time-dependent winds from this model are used as input to a separate tracer model. The methodologies employed to construct the tracer model are described.The experiment presented is the evolution of a hypothetical instantaneous source of tracer on 1 Janaury with maximum initial concentration at 65 mb, 36 0 N, 180 0 E. The tracer is assumed to have no sources or sinks in the stratosphere, but is subject to removal processes in the lower troposphere.The experimental results reveal a number of similarities to observed tracer behavior, including the average poleward-downward slope of mixing ratio isopleths, strong tracer gradients across the tropopause, intrusion of tracer into the Southern Hemisphere lower stratosphere, and the long-term interhemispheric exchange rate. The model residence times show behavior intermediate to those exhibited for particulate radioactive debris and gaseous C 14 O 2 . This suggests that caution should be employed when either radioactive debris or C 14 O 2 data are used to develop empirical models for prediction of gaseous tracers which are efficiently removed in the troposphere.In this experiment, the tracer mixing ratio and potential vorticity evolve to very high correlations. Mechanisms for this correlation are discussed. The zonal mean tracer balances exhibit complex behavior among the various transport terms. At early stages, the tracer evolution is dominated by eddy effects. Later, a very large degree of self-cancellation between mean cell and eddy effects is observed. During seasonal transitions, however, this self-cancellation diminishes markedly, leading to significant changes in the zonal mean tracer distribution. A possible theoretical explanation is presented

  12. Sequential logic analysis and synthesis

    CERN Document Server

    Cavanagh, Joseph

    2007-01-01

    Until now, there was no single resource for actual digital system design. Using both basic and advanced concepts, Sequential Logic: Analysis and Synthesis offers a thorough exposition of the analysis and synthesis of both synchronous and asynchronous sequential machines. With 25 years of experience in designing computing equipment, the author stresses the practical design of state machines. He clearly delineates each step of the structured and rigorous design principles that can be applied to practical applications. The book begins by reviewing the analysis of combinatorial logic and Boolean a

  13. Granular controls on the dispersion of bed load tracers

    Science.gov (United States)

    Jerolmack, D. J.; Martin, R. L.; Phillips, C. B.

    2014-12-01

    Coarse particles are transported in a river as bed load, i.e., they move in frequent contact with and are supported by the granular bed. This movement is typically intermittent and may be described by a series of steps are rests, the distributions of which determine particle dispersion. Laboratory and field studies of bed load tracer dispersion have reported sub- and super-diffusive behavior, both of which have been successfully reproduced with stochastic transport models. Although researchers have invoked heavy-tailed step lengths as the cause of anomalous dispersion, most observations report thin-tailed distributions. Little attention has been paid to rest periods, and stochastic transport models have not been connected to the underlying mechanics of particle motion. Based on theoretical and experimental evidence, we argue that step lengths are thin-tailed and do not control the longterm dispersion of bed load tracers; they are determined by momentum balance between the fluid and solid. Using laboratory experiments with both marbles and natural sediments, we demonstrate that the rest time distribution is power law, and argue that this distribution controls asymptotic dispersion. Observed rest times far exceed any hydrodynamic timescale. Experiments reveal that rest times of deposited particles are governed by fluctuations in river bed elevation; in particular, the return time for the bed to scour to the base of a deposited particle. Stochastic fluctuations in bed elevation are describable by an Ornstein-Uhlenbeck (mean-reverting random walk) model that contains two parameters, which we show are directly related to the granular shear rate and range of bed elevation fluctuations, respectively. Combining these results with the theory of asymmetric random walks (particles only move downstream), we predict superdiffusive behavior that is in quantitative agreement with our observations of tracer dispersion in a natural river.

  14. Double tracer experiments to evaluate atmospheric transport and dose models

    International Nuclear Information System (INIS)

    Nielsen, S.P.; Gryning, S.-E.; Thykier-Nielsen, S.; Karlberg, O.; Lyck, E.

    1986-05-01

    Two tracers, sulphurhexafluoride (SF 6 ) and radioactive noble gases, were released simultaneously from a 110-m stack and detected downwind at distances of 3-4 km. The experiments were made at the Swedish nuclear power plant Ringhals in 1981. The radioactive tracer was routine emissions from unit 1 (BWR). The one-hour measurements yielded crosswind profiles at ground level of SF 6 -concentrations and of gamma radiation from the plume. The measured profiles were compared to profiles calculated with computer models. The comparison showed that the models sometimes underestimate and sometimes overestimate the results, which seems to indicate that the models within their limited accuracy yield unbiased results. The ratios between measured and calculated values range from 0.2 to 3. The measurements revealed a surplus of gamma radiations from the noble gas daughters compared to those from the gases. This was interpreted as due to ground desposition and the estimated deposition velocities range from 2 to 10 cm/s. The meteorological conditions were monitored from a 100-m meteorological tower and from an 11-m mast. Measurements were made of wind speed, wind direction, and temperatures at different heights, and during each experiment a mini-radiosonde was released giving information on a possible inversion layer. The SF 6 -tracer was injected to the stack prior to the experiments. Air-samples were collected downwind in plastic bags by radio-controlled sampling units. The SF 6 -concentrations in the bags were determined with gas chromatography. Measurements of the gamma radiation from the plume were made with ionisation chambers and GM-counters. Furthermore, a few mobile gamma spectrometers were available giving information on the unscattered gamma radiation, thereby permitting identification of the radioactive isotopes. The work was partly financed by the Nuclear Safety Board of the Swedish Utilities and by the Danish association of utilities in Jutland and on Funen, Elsam

  15. Natural tracer profiles across argillaceous formations: the Claytrac project

    International Nuclear Information System (INIS)

    Mazurek, M.; Alt-Epping, P.; Gimi, Th.; Niklaus Waber, H.; Bath, A.; Gimmi, Th.

    2009-01-01

    Disposal of high-level radioactive waste and spent nuclear fuel in engineered facilities, or repositories, located deep underground in suitable geological formations is being developed worldwide as the reference solution to protect humans and the environment both now and in the future. An important aspect of assessing the long-term safety of deep geological disposal is developing a comprehensive understanding of the geological environment in order to define the initial conditions for the disposal system as well as to provide a sound scientific basis for projecting its future evolution. The transport pathways and mechanisms by which contaminants could migrate in the surrounding host rock are key elements in any safety case. Relevant experiments in laboratories or underground test facilities can provide important information, but the challenge remains in being able to extrapolate the results to the spatial and temporal scales required for performance assessment, which are typically tens to hundreds of metres and from thousands to beyond a million years into the future. Profiles of natural tracers dissolved in pore water of argillaceous rock formations can be considered as large-scale and long-term natural experiments which enable the transport properties to be characterised. The CLAYTRAC Project on Natural Tracer Profiles Across Argillaceous Formations was established by the NEA Clay Club to evaluate the relevance of natural tracer data in understanding past geological evolution and in confirming dominant transport processes. Data were analysed for nine sites to support scientific understanding and development of geological disposal. The outcomes of the project show that, for the sites and clay-rich formations that were studied, there is strong evidence that solute transport is controlled mainly by diffusion. The results can improve site understanding and performance assessment in the context of deep geological disposal and have the potential to be applied to other

  16. Environmental radionuclides tracers and timers of terrestrial processes

    CERN Document Server

    Froehlich, Klaus

    2009-01-01

    The book presents a state-of-the-art summary of knowledge on the use of radionuclides to study processes and systems in the continental part of the Earth's environment. It is conceived as a companion to the two volumes of this series, which deal with isotopes as tracers in the marine environment (Livingston, Marine Radioactivity) and with the radioecology of natural and man-made terrestrial systems (Shaw, Radioactivity in Terrestrial Ecosystems). Although the book focuses on natural and anthropogenic radionuclides (radioactive isotopes), it also refers to stable environmental isotopes, which i

  17. Can radiocaesium be used as a tracer for vegetal nutrients?

    International Nuclear Information System (INIS)

    Anjos, R. M.; Mosquera, B.; Carvalho, C.; Sanches, N.; Bastos, J.; Macario, K.; Vezzone, M.; Gomes, P.R.S.

    2007-01-01

    In recent years, there has been a growing interest in the evaluation of nutrient fluxes and radioactive contaminants in forest and agricultural ecosystems. Several studies on forest ecosystems have been carried out, mostly in Europe, after the Chernobyl accident. These studies have been performed mainly in the development of models for predicting the radiocaesium behavior in the soil and plant compartments of forest systems. However, research on the use of radiocaesium as a tracer for vegetal nutrients has shown that, despite the fact that caesium is a weakly hydrated alkaline metal and has chemical similarities to potassium and ammonium, this is still a complex problem requiring, then, more experimental results. Additionally, very little is known about the mechanisms involved in the radionuclide uptake and retention by tropical plants. In order to contribute to the understanding of the relative behavior of caesium, potassium and ammonium and to investigate whether radiocaesium can be used as a tracer for vegetal nutrients, the Laboratory of Radioecology (LARA) of the Federal Fluminense University has been performing analysis of 137 Cs, 40 K and NH 4 concentrations in several vegetal compartments of agricultural tropical plants, such as guava (Psidium guajava), mango (Mangifera indica), avocado (Persea americana), pomegranate (Punica granatum), papaya (Carica Papaya), banana (Musa paradisiaca), manioc (Manihot Esculenta), and chili pepper (Capsicum fructescens) trees. Measurements of 137 Cs, 40 K and NH 4 concentrations show that these elements can be very mobile within a plant, exhibiting the highest values of concentration in the growing parts of the trees: fruits, leaves, twigs, barks and the outer growth layers. On the other hand, our results indicate that for wood trees (such as guava, mango, avocado, pomegranate and chili pepper trees) do both caesium and the vegetal nutrients have simultaneously higher concentrations in the youngest rather than in the oldest

  18. On the numerical simulation of tracer flows in porous media

    International Nuclear Information System (INIS)

    Aquino, J.; Pereira, F.; Amaral Souto, H.P.; Francisco, A.S.

    2007-01-01

    We discuss in detail a new Lagrangian, locally conservative procedure which has been proposed for the numerical solution of linear transport problems in porous media. The new scheme is computationally efficient, virtually free of numerical diffusion, and can be applied to investigate numerically the time evolution of radionuclide contaminant plumes. Results of two-dimensional simulations of tracer flows will be presented to show the influence on the computed solutions of distinct interpolation functions for evaluating the velocity field at any position of the physical domain, as required by the Lagrangian scheme. (author)

  19. Tracer sa route, en toute intransparence numérique ?

    Directory of Open Access Journals (Sweden)

    Philippe Vidal

    2015-12-01

    Full Text Available « Comme l’intransparence des vitres ferait tache dans une habitation et l’attristerait en obstruant le passage du regard, on a dû chercher au moyen de voir au travers sans être vu, et l’on a inventé le verre mousseline. » L’expression « tracer sa route » est souvent utilisée dans un sens familier. Elle signifie, ordinairement, partir à l’aventure, sans se soucier des éventuelles contraintes et conséquences d’un tel choix, qu’elles soient sociales, matérielles ou familiales. A l’image des trav...

  20. A single hole tracer test to determine longitudinal dispersion

    International Nuclear Information System (INIS)

    Noy, D.J.; Holmes, D.C.

    1986-03-01

    The paper concerns a single hole tracer test to determine longitudinal dispersion, which is an important parameter in assessing the suitability of a site for radioactive waste disposal. The theory, equipment and procedure for measuring longitudinal dispersion in a single borehole is described. Results are presented for field trials conducted in an aquifer, where the technique produced good results. The measured value of longitudinal dispersion, from a single hole test, relates only to a limited volume of rock immediately adjacent to the borehole. (U.K.)

  1. Preparation of radioactive tracer for studying sediment movement

    International Nuclear Information System (INIS)

    Hussain, S.D.; Ghauri, G.A.; Qureshi, M.H.; Khan, N.A.

    1983-06-01

    In order to study the movement of sediment in harbours, estuaries and streams, artificial sediment in the form of glass is prepared. A preselected nuclide is added to the glass during its manufacture. The density and size distribution of the glass particles is method with that of the natural sediment. The activation of the artificial sediment in a reactor changes the nuclide into a radioactive isotope thereby tagging it and making it possible to trace its movement with suitable radiation detector. The method of tracer preparation is described with special reference to sadiment movement studies at Karachi harbour. (authors)

  2. Use of medical imaging as an epidemiologic tracer

    International Nuclear Information System (INIS)

    Dartigues, J.F.

    1987-01-01

    Medical imaging is a source of data for clinical and epidemiological research just like any other factual information obtained during medical treatment. Medical imaging data, like any other information, are not really useful unless they are obtained in rigorously controlled and determined conditions, defined a priori in the research protocol. In order to be use as an epidemiologic tracer (that is, as a meaning of finding a given pathology in a given population and during a given time period), the imaging data have to be valid, reliable, and representative, of easy access and obtained at a low cost [fr

  3. Application of tracers in the fight against hydrological pollution

    International Nuclear Information System (INIS)

    Guizerix, J.; Margrita, R.

    1978-01-01

    A statement is made on the laboratory know-how in the field of the applications of tracers in the fight against hydrological pollution. In surface hydrology it concerns the determination of the self-purifying powers of watercourses and the treatment of a certain number of problems relating to the transfer of polluting substances to the hydrographical system. In hydrogeology, the various studies made and being made deal with the transfer of water, a vector of pollution, with the interaction of polluting agents with the porous environment, and thus with the general problem of the protection of underground water catchments [fr

  4. Radioactive tracer system to indicate drill bit wear or failure

    International Nuclear Information System (INIS)

    Fries, B.A.

    1975-01-01

    A radioactive tracer system for indicating drill bit wear or failure utilizing radioactive krypton 85 in clathrate form, in the form of water-soluble kryptonates, or dissolved grease, is described. Preferably the radioactive krypton is placed so that when drill bit wear or failure occurs, the radioactive krypton 85 is relased and effectively becomes diffused in the circulating drilling fluid. At the surface, the radioactive krypton 85 gas is separated from the circulating drilling fluid by gas-mud separating means and is transported as a gas to a counting chamber where an accurate radioactivity count of beta rays released from the krypton is obtained. (Patent Office Record)

  5. Dispersion of tracers by the oceanic eddy field modelling programme

    International Nuclear Information System (INIS)

    Richards, K.J.

    1986-01-01

    A numerical model has been developed to study the dispersion of tracers by the oceanic eddy field. The study is designed to investigate the horizontal and vertical structure of the eddies and how this structure is influenced by the bottom topography. It is found that hills and valleys have a strong effect on the eddies above them. The flow close to the bottom has a tendency to be steered by the height contours. The surface and bottom flows become decorrelated and the vertical variation of the kinetic energy of the eddies is increased with higher topographic features. (author)

  6. Dual-gas tracers for subsurface characterization and NAPL detection

    International Nuclear Information System (INIS)

    Gauglitz, P.A.; Peurrung, L.M.; Mendoza, D.P.; Pillay, G.

    1994-11-01

    Effective design of in situ remediation technologies often requires an understanding of the mass transfer limitations that control the removal of contaminants from the soil. In addition, the presence of nonaqueous phase liquids (NAPLs) in soils will affect the ultimate success or failure of remediation processes. Knowing the location of NAPLs within the subsurface is critical to designing the most effective remediation approach. This work focuses on demonstrating that gas tracers can detect the location of the NAPLs in the subsurface and elucidating the mass transfer limitations associated with the removal of contaminants from soils

  7. Preparation of uranium-230 as a new uranium tracer

    International Nuclear Information System (INIS)

    Hashimoto, T.; Kido, K.; Sotobayashi, T.

    1977-01-01

    A uranium isotope, 230 U(T=20.8 d), was produced from the 231 Pa(γ,n) 230 Pa→viaβ - decay 230 U process with a bremsstrahlung irradiation on a protactinium target. After standing for about one month to obtain a maximal growth of 230 U, the uranium was chemically purified, applying an ion-exchange method. The purity of the 230 U obtained was examined with alpha spectrometry and an intrinsic alpha peak due to 230 U as a new uranium tracer in an alpha spectrometric analysis of uranium isotopes is described. (author)

  8. Study of transport in unsaturated sands using radioactive tracers

    International Nuclear Information System (INIS)

    Merritt, W.F.; Pickens, J.F.; Allison, G.B.

    1979-01-01

    A laboratory experiment was conducted to investigate the mixing that occurs as a series of labelled pulses of water are transported by gravity drainage down through a sand filled column having a water table imposed at the bottom. It also demonstrated the utility of gamma-ray emitting radioactive tracers in studying transport in unsaturated or saturated porous media. The motivation for pursuing this topic was developed from observing that the content of oxygen-18, deuterium and tritium in rainwater shows marked temporal variations whereas their concentrations below the water table in shallow ground water flow systems are generally found to show much less variation. (auth)

  9. Determination of viscosity in recirculating fluidized bed using radioactive tracer

    International Nuclear Information System (INIS)

    Silva, G.G. da.

    1986-01-01

    The use of radioactive tracer for measuring viscosity is proposed. The methodology relates the terminal velocity of a radioactive sphere in interior of fluid with the viscosity, which can be a fluidized bed or total flow of solids. The arrangement is composed by two γ detectors placed externally and along the bed. Both detectors are coupled by amplifier to electronic clock. The drop time of sphere between two detectors is measured. The bed viscosity two detectors is measured. The bed viscosity is calculated from mathematical correlations of terminal velocity of the sphere. (M.C.K.)

  10. Water Vapor Tracers as Diagnostics of the Regional Hydrologic Cycle

    Science.gov (United States)

    Bosilovich, Michael G.; Schubert, Siegfried D.; Einaudi, Franco (Technical Monitor)

    2001-01-01

    Numerous studies suggest that local feedback of surface evaporation on precipitation, or recycling, is a significant source of water for precipitation. Quantitative results on the exact amount of recycling have been difficult to obtain in view of the inherent limitations of diagnostic recycling calculations. The current study describes a calculation of the amount of local and remote geographic sources of surface evaporation for precipitation, based on the implementation of three-dimensional constituent tracers of regional water vapor sources (termed water vapor tracers, WVT) in a general circulation model. The major limitation on the accuracy of the recycling estimates is the veracity of the numerically simulated hydrological cycle, though we note that this approach can also be implemented within the context of a data assimilation system. In the WVT approach, each tracer is associated with an evaporative source region for a prognostic three-dimensional variable that represents a partial amount of the total atmospheric water vapor. The physical processes that act on a WVT are determined in proportion to those that act on the model's prognostic water vapor. In this way, the local and remote sources of water for precipitation can be predicted within the model simulation, and can be validated against the model's prognostic water vapor. As a demonstration of the method, the regional hydrologic cycles for North America and India are evaluated for six summers (June, July and August) of model simulation. More than 50% of the precipitation in the Midwestern United States came from continental regional sources, and the local source was the largest of the regional tracers (14%). The Gulf of Mexico and Atlantic regions contributed 18% of the water for Midwestern precipitation, but further analysis suggests that the greater region of the Tropical Atlantic Ocean may also contribute significantly. In most North American continental regions, the local source of precipitation is

  11. Tritium and deuterium as water tracers in hydrologic systems. Completion report

    International Nuclear Information System (INIS)

    Stewart, G.L.; Stetson, J.R.

    1975-05-01

    A study was conducted to evaluate the suitability of deuterium and tritium as tracers to depict water and pollutant movement in porous media. This involved studying the interaction of these tracers with soil materials and evaluating this interaction in terms of retardation in tracer flow velocity, compared to bulk water flow. Previous work had suggested that tritium and deuterium interact with soils and are removed from tracer solution during flow. The data presented clearly show that a tracing front becomes diluted in tracer during infiltration into oven-dried soil. There appears to be very little difference between the degree of tritium and deuterium interaction. The source of interaction is demonstrated to be primarily hydroxyl associated with the clay minerals. These exchange sites are destroyed by heating soil to 70C which eliminates tracer loss during infiltration

  12. Use of (3H) and (125I) tracers in steroid radioimmunoassays

    International Nuclear Information System (INIS)

    Jeffcoate, S.L.

    1975-01-01

    The comparative use of 3 H and 125 I tracers in steroid radioimmunoassays will be discussed around the following points: - 3 H. Advantages: they can be purchased commercially and have a long shelf-life. Disadvantages: they may have reduced affinity for antibodies due to ''isotope effects''; the counting of β-emitters is more expensive and difficult; 3 H tracers are not available for all steroids. - 125 I. Advantages: gamma-counting is cheaper, simpler and more precise; 125 I tracers may have higher affinity for antibodies than unlabelled steroids; 125 I can be used to label any steroid. Disadvantages: 125 I tracers have a limited shelf-life (n.b. six months for 125 I histamine tracers). The high affinity of some tracers will be a big disadvantage if the unlabelled steroid cannot compete effectively

  13. An experimental study of tracers for labelling of injection gas in oil reservoirs

    International Nuclear Information System (INIS)

    Dugstad, Oe.

    1992-01-01

    This work demonstrates the feasibility of the PMCP and PMCH as tracers in field experiments. These compounds have properties which make them as well suited for well to well studies as the more common tracers CH 3 T and 85 Kr. In an injection project carried out at the Gullfaks field in the North Sea the two PFCs verified communication between wells. This implies communication between different geological layers in the reservoir and also communication across faults within the same layers. Laboratory studies carried out have focused on the retention of the tracers in dynamic flooding experiments under conditions comparable with those in the petroleum reservoirs. Simultaneous injection of a variety of tracers has shown individual variations in tracer retention which are caused by important reservoir parameters as fluid saturation and rock properties. By proper design of field injection programs the tracers response may therefore be used to estimate fluid saturation if actual rock properties are known. 45 refs., 20 figs., 13 tabs

  14. Development and Validation of Water Vapor Tracers as Diagnostics for the Atmospheric Hydrologic Cycle

    Science.gov (United States)

    Bosilovich, Michael G.; Schubert, Siegfried D.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    Understanding of the local and remote sources of water vapor can be a valuable diagnostic in understanding the regional atmospheric hydrologic cycle. In the present study, we have implemented passive tracers as prognostic variables to follow water vapor evaporated in predetermined regions until the water tracer precipitates. The formulation of the sources and sinks of tracer water is generally proportional to the prognostic water vapor variable. Because all water has been accounted for in tracers, the water vapor variable provides the validation of the tracer water and the formulation of the sources and sinks. The tracers have been implemented in a GEOS General Circulation Model (GCM) simulation consisting of several summer periods to determine the source regions of precipitation for the United States and India. The recycling of water and interannual variability of the sources of water will be examined. Potential uses in GCM sensitivity studies, predictability studies and data assimilation will be discussed.

  15. COMPARISON OF THREE TRACER TESTS AT THE RAFT RIVER GEOTHERMAL SITE

    Energy Technology Data Exchange (ETDEWEB)

    Earl D Mattson; Mitchell Plummer; Carl Palmer; Larry Hull; Samantha Miller; Randy Nye

    2011-02-01

    Three conservative tracer tests have been conducted through the Bridge Fault fracture zone at the Raft River Geothermal (RRG) site. All three tests were conducted between injection well RRG-5 and production wells RRG-1 (790 m distance) and RRG-4 (740 m distance). The injection well is used during the summer months to provide pressure support to the production wells. The first test was conducted in 2008 using 136 kg of fluorescein tracer. Two additional tracers were injected in 2010. The first 2010 tracer injected was 100 kg fluorescein disodium hydrate salt on June, 21. The second tracer (100 kg 2,6-naphthalene disulfonic acid sodium salt) was injected one month later on July 21. Sampling of the two productions wells is still being performed to obtain the tail end of the second 2010 tracer test. Tracer concentrations were measured using HPLC with a fluorescence detector. Results for the 2008 test, suggest 80% tracer recover at the two production wells. Of the tracer recovered, 85% of tracer mass was recovered in well RRG-4 indicating a greater flow pathway connection between injection well and RRG-4 than RRG-1. Fluorescein tracer results appear to be similar between the 2008 and 2010 tests for well RRG-4 with peak concentrations arriving approximately 20 days after injection despite the differences between the injection rates for the two tests (~950 gpm to 475 gpm) between the 2008 and 2010. The two 2010 tracer tests will be compared to determine if the results support the hypothesis that rock contraction along the flow pathway due to the 55 oC cooler water injection alters the flow through the ~140 oC reservoir.

  16. Tracer techniques in karst hydrogeology. Application to the location of karst aquifers

    International Nuclear Information System (INIS)

    Mangin, A.; Molinari, J.

    1976-01-01

    From the recent progress in karst aquifer simulation techniques and the improved knowledge of tracers, the old-established tracer technique has become an invaluable instrument for hydrogeological survey work. Typical information obtainable includes karst system boundaries features and location of hydrodynamic discontinuities, flow variation in both space and time. Tracer methods are a basic requirement for investigation of karst groundwater supplies and determining protection zones for water supply points [fr

  17. The use of tracer techniques to measure water flow rates in steam turbines

    International Nuclear Information System (INIS)

    Whitfield, O.J.; Blaylock, G.; Gale, R.W.

    1979-01-01

    Radioactive and chemical tracers offer some unique advantages in detailed flow measurement on steam turbine plant. A series of experiments on a nuclear power station are reported where tracers successfully measured water flow rates and the initial steam moisture with an accuracy suitable for performance and commissioning tests. Both radioactive and chemical tracer methods produced identical results. Straightforward practical procedures were evolved that ensured repeatable accuracy and in addition a quantitative method of detecting heater leaks on load was established. (author)

  18. Teaching Resources

    Science.gov (United States)

    Physics?" Poster Pamphlets/Books/SPIN-UP Resources Making and Sustaining Changes in Undergraduate AAPT.org - American Association of Physics Teachers Skip to content Skip to navigation Skip to local navigation AAPT - American Association of Physics Teachers Go Sign In / Online Services Join

  19. Resource Mobilization

    International Development Research Centre (IDRC) Digital Library (Canada)

    constitute endorsement of the product and is given only for information. ..... point where they could significantly impact an organization's financial viability. This alternative ... putting in place internal systems and processes that enable the resource .... control over the incorporation of non-profit organizations. ..... Accounting.

  20. Resource Mobilization

    International Development Research Centre (IDRC) Digital Library (Canada)

    Annex 1: The Scoping Study on Donor Funding for. Development Research in ... publication of the Resource Mobilization: A Practical Guide for Research .... applied the concept or technique, which validates the practical application of ... some other staff member would write up a grant application addressed to one, two, or a ...

  1. Wirelessly powered micro-tracer enabled by miniaturized antenna and microfluidic channel

    International Nuclear Information System (INIS)

    Duan, G; Zhao, X; Seren, H R; Chen, C; Zhang, X

    2015-01-01

    A miniaturized antenna, 380μm by 380μm in size, was fabricated and integrated with a commercialized passive RFID chip to form a micro-tracer, whose size was 2mm by 1mm in total. The micro-tracer was wirelessly powered and interrogated by a single layer spiral reader antenna through near field coupling. To maximize the working distance, the resonant frequency of micro-tracer and reader antenna were matched at 840MHz. Due to the ultra small size of the tracer antenna, power transfer efficiency decreased dramatically as the distance between tracer antenna and reader antenna increased, thus the working distance of the microtracer was limited within 1mm. To achieve massive operation of the micro-tracer, a microfluidic platform was fabricated with in channel focusing and separation. Acrylic sheets were laser cut to define the channel and cover structure, then bonded together layer by layer with a glass substrate, on which reader antenna was integrated. Pump oil was used as the fluidic media carrying the micro-tracer flowing inside the microfluidic channel. The wireless power transfer and real-time communication was demonstrated with the micro-tracer flowing above the reader antenna, as the ID of the micro-tracer was retrieved and displayed on a computer screen. (paper)

  2. On-line measurements of liquid carry-over from scrubbers using radioactive tracers

    Energy Technology Data Exchange (ETDEWEB)

    Haugan, A; Hassfjell, S [Institute for Energy Technology, Kjeller (Norway); Finborud, A [Mator, Porsgrunn (Norway)

    2004-07-01

    A method to measure liquid carry-over from scrubbers using gamma-emitting tracers is described and results from field tests at two onshore installations are presented. One water/1,2-ethanediol (MEG) and two hydrocarbon liquid (condensate) tracers have been used in the tests. One of the condensate tracers deposited to some extent inside the process pipe, while the other had a too high vapor pressure. The water/MEG tracer showed no MEG carry-over while the carry-over of MEG was documented to be considerable. (author)

  3. On-line measurements of liquid carry-over from scrubbers using radioactive tracers

    International Nuclear Information System (INIS)

    Haugan, A.; Hassfjell, S.; Finborud, A.

    2004-01-01

    A method to measure liquid carry-over from scrubbers using gamma-emitting tracers is described and results from field tests at two onshore installations are presented. One water/1,2-ethanediol (MEG) and two hydrocarbon liquid (condensate) tracers have been used in the tests. One of the condensate tracers deposited to some extent inside the process pipe, while the other had a too high vapor pressure. The water/MEG tracer showed no MEG carry-over while the carry-over of MEG was documented to be considerable. (author)

  4. Plan for radionuclide tracer studies of the residence time distribution in the Wilsonville dissolver and preheater

    International Nuclear Information System (INIS)

    Jolley, R.L.; Begovich, J.M.; Brashear, H.R.

    1983-12-01

    Stimulus-response measurements using radiotracers to measure residence time distribution (RTD) and hydrodynamic parameters for the preheaters and dissolvers at the Ft. Lewis Solvent Refined Coal (SRC) and the Exxon Donor Solvent (EDS) coal conversion pilot plants are reviewed. A plan is also presented for a series of radioactive tracer studies proposed for the Advanced Coal Liquefaction Facility at Wilsonville, Alabama, to measure the RTD for the preheater and dissolvers in the SRC-I mode. The tracer for the gas phase will be 133 Xe, and 198 Au (on carbonized resin or as an aqueous colloidal suspension) will be used as the slurry tracer. Four experimental phases are recommended for the RTD tracer studies: (1) preheater; (2) dissolver with 100% takeoff; (3) dissolver with 100% takeoff and solids withdrawal; and (4) dissolver with 50% takeoff. Eighteen gas-tracer and 22 liquid-tracer injections are projected to accomplish the four experimental phases. Two to four tracer injections are projected for preliminary tests to ensure the capability of safe injection of the radiotracers and the collection of statistically significant data. A complete projected cost and time schedule is provided, including procurement of necessary components, preparation of the radiotracers, assembly and testing of tracer injection apparatus and detection systems, onsite work and tracer injections, laboratory experimentation, data analysis, and report writing

  5. Tracer technique for measuring specific activity of 63 Ni, using 4πβ-γ

    International Nuclear Information System (INIS)

    Iwahara, A.

    1979-01-01

    The specific activity of a 6 3 Ni solution has been measured by an efficiency tracer technique using a 4 π β - γ coincidence system. 6 3 Ni was chosen. Because it's a very low energy pure beta emitter. Due to chemical compatibility and beta spectral shapes, 6 0 Co has been chosen as tracer. In the determination of 6 3 Ni, the specific activity. As the efficiency tracer techniques requires a previous knowledge of tracer activity, this has been measured by a conventional 4 π β -γ coincidence method. (author)

  6. USE OF PERFLUOROCARBON TRACER (PFT) TECHNOLOGY FOR SUBSURFACE BARRIER INTEGRITY VERIFICATION AT THE WALDO TEST SITE

    Energy Technology Data Exchange (ETDEWEB)

    SULLIVAN,T.; HEISER,J.; SENUM,G.; MILLIAN,L.

    2000-02-27

    Researchers from Brookhaven National Laboratory (BNL) tested perfluorocarbon (PFT) gas tracers on a subsurface barrier with known flaws at the Waldo test facility [operated by Science and Engineering Associates, Inc (SEA)]. The tests involved the use of five unique PFT tracers with a different tracer injected along the interior of each wall of the barrier. A fifth tracer was injected exterior to the barrier to examine the validity of diffusion controlled transport of the PFTs. The PFTs were injected for three days at a nominal flow rate of 15 cm{sup 3}/min and a concentrations in the range of a few hundred ppm. Approximately 65 liters of air laced with tracer was injected for each tracer. The tracers were able to accurately detect the presence of the engineered flaws. Two flaws were detected on the north and east walls and lane flaw was detected on the south and west walls. In addition, one non-engineered flaw at the seam between the north and east walls was also detected. The use of multiple tracers provided independent confirmation of the flaws and permitted a distinction between tracers arriving at a monitoring port after being released from a nearby flaw and non-engineered flaws. The PFTs detected the smallest flaw, 0.5 inches in diameter. Visual inspection of the data showed excellent agreement with the known flaw locations and the relative size of the flaws was accurately estimated.

  7. The use of synthetic colloids in tracer transport experiments in saturated rock fractures

    International Nuclear Information System (INIS)

    Reimus, P.W.

    1995-08-01

    Studies of groundwater flow and contaminant transport in saturated, fractured geologic media are of great interest to researchers studying the potential long-term storage of hazardous wastes in or near such media. A popular technique for conducting such studies is to introduce tracers having different chemical and physical properties into a system and then observe the tracers at one or more downstream locations, inferring flow and transport mechanisms from the breakthrough characteristics of the different tracers. Many tracer studies have been conducted in saturated, fractured media to help develop and/or refine models capable of predicting contaminant transport over large scales in such media

  8. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System.

    Science.gov (United States)

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 ((90)Y) and lutetium-177 ((177)Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. All syntheses were carried out using the Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) (177)Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. A total of 17 [(177)Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [(177)Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. The automated synthesis of [(177)Lu]-DOTATATE using Eckert & Ziegler Eurotope's Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA (177)Lu and almost negligible radiation exposure of the operators.

  9. Procedure guide for the implementation of quality management program in products and services link with the utilization of tracers technology (TT) and Nucleonic Control System

    International Nuclear Information System (INIS)

    Resnizky, S.; Banados Perez, H.; Longo, G.; Rodriguez Cardona, R.L.; Sebastian Calvo, C.; Kohnenkamp O, I.; Duran P, O.

    2000-01-01

    This Manual was elaborated in the mark of the project RLA/8/024 ARCAL XLII 'Industrial Applications of the Tracer Technology and Nucleonic Control Systems'. The objective of the present Quality Manual is to spread the Quality Policy and to describe the form of implementing the Quality Management System, according to the requirements of the Standard ISO 9001:2000. It is applied to the design, development, implementation and maintenance of the products of the Organization of Tracers Technology (TT) and Nucleonic Control Systems (SCN). It have 9 Section: I. Introduction, II. Normative references, III. Definitions, IV. Quality Management System; V. Direction Responsibility; VI. Resources Management; VII. Products Accomplishment; VIII. Measurement, Analysis and Improvement and 7 Annex

  10. Water tracers in the general circulation model ECHAM

    International Nuclear Information System (INIS)

    Hoffmann, G.; Heimann, M.

    1993-01-01

    We have installed a water tracer model into the ECHAM General Circulation Model (GCM) parameterizing all fractionation processes of the stable water isotopes ( 1 H 2 18 O and 1 H 2 H 16 O). A five year simulation was performed under present day conditions. We focus on the applicability of such a water tracer model to obtain information about the quality of the hydrological cycle of the GCM. The analysis of the simulated 1 H 2 18 O composition of the precipitation indicates too weak fractionated precipitation over the Antarctic and Greenland ice sheets and too strong fractionated precipitation over large areas of the tropical and subtropical land masses. We can show that these deficiencies are connected with problems of model quantities such as the precipitation and the resolution of the orography. The linear relationship between temperature and the δ 18 O value, i.e. the Dansgaard slope, is reproduced quite well in the model. The slope is slightly too flat and the strong correlation between temperature and δ 18 O vanishes at very low temperatures compared to the observations. (orig.)

  11. Acupuncture meridians demythified. A study using the radioactive tracer method

    International Nuclear Information System (INIS)

    Simon, J.; Esquerre, J.P.; Guiraud, R.; Guiraud, G.; Lazorthes, Y.

    1988-01-01

    Radioactive trajectories can be visualized by injecting a radioactive tracer, technetium 99 m, at the site of acupuncture points. To determine the exact nature of these trajectories we performed several experiments on healthy volunteers, and our results may be summarized as follows. The target organs of technetium 99 m, and notably the thyroid gland, were always visualized. The circulating radioactivity, visible on scintiscans and confirmed by venous blood counts, was not negligible. The radioactive trajectories we observed were often divided at their starting point and did not extend along the whole length of the acupuncture meridians they might have made visible. The radioactive trajectories disappeared after venous blockade to reappear when the blockade was lifted. Finally, the radioactive trajectories obtained were very similar after injection at the acupuncture point and at a control point. These findings indicate a lymphatic and venous drainage of the radioactive tracer at the site of injection followed by transportation through the veins, rather than visualization of acupuncture meridians as suggested by some authors [fr

  12. Acupuncture meridians demythified. A study using the radioactive tracer method

    Energy Technology Data Exchange (ETDEWEB)

    Simon, J.; Esquerre, J.P.; Guiraud, R.; Guiraud, G.; Lazorthes, Y.

    1988-07-01

    Radioactive trajectories can be visualized by injecting a radioactive tracer, technetium 99 m, at the site of acupuncture points. To determine the exact nature of these trajectories we performed several experiments on healthy volunteers, and our results may be summarized as follows. The target organs of technetium 99 m, and notably the thyroid gland, were always visualized. The circulating radioactivity, visible on scintiscans and confirmed by venous blood counts, was not negligible. The radioactive trajectories we observed were often divided at their starting point and did not extend along the whole length of the acupuncture meridians they might have made visible. The radioactive trajectories disappeared after venous blockade to reappear when the blockade was lifted. Finally, the radioactive trajectories obtained were very similar after injection at the acupuncture point and at a control point. These findings indicate a lymphatic and venous drainage of the radioactive tracer at the site of injection followed by transportation through the veins, rather than visualization of acupuncture meridians as suggested by some authors.

  13. Dispersion of dissolved tracers released at the seafloor

    International Nuclear Information System (INIS)

    Kupferman, S.L.; Moore, D.E.

    1983-01-01

    The authors present scenarios that describe the temporal and spatial development of a concentration field of a dissolved tracer released at the seafloor for one Pacific and two Atlantic study areas. The scenarios are closely tied to available data by means of simple analytical models, and they proceed in stages from short time and space scales in the immediate vicinity of a release point to those scales characteristic of entire ocean basins. They introduce and discuss the concepts of internal mixing time and residence time in the benthic mixed layer, which are useful for developing an intuitive feeling for the behavior of a tracer. They also introduce the concept of domain of occupation, which is useful in drawing distinctions between mixing and stirring in the ocean. From this study it is apparent that reliable estimation of mixing will require careful consideration of the dynamics of the eddy fields in the ocean. In addition they urgently need more information that relates isopycnal structure and bottom topography to local near-bottom circulation

  14. Soil homogeneity evaluation by radionuclide tracer breakthrough curve interpretation

    International Nuclear Information System (INIS)

    Brenizer, J.S. Jr.; Jarrett, A.R.; Jester, W.A.

    1980-01-01

    Increasing concern about the environmental impact of hazardous waste disposal has made site evaluation and site selection difficult and expensive. Pollutants, assumed to be absorbed by the soil immediately surrounding the burial trench, have been detected far from sites. Discrepancies between predicted migration distances based on indirect methods such as laboratory and computer modeling and those observed at the field site are often significant. The homogeneity of subsurface media, often assumed in laboratory and modeling studies, is seldom found in the field. The use of tracers to determine the flow characteristics of a potential disposal site involves time and expense, but offers a direct evaluation of solute transport and eliminates the assumptions inherent in indirect methods. Current modeling of solute transport in nonhomogeneous porous media is limited by the quantification of input parameters. Several general models can predict solute transport in saturated-unsaturated media from low-level disposal sites if the hydraulic characteristics and chemical reactions expected in each unique water-solute-media system can be defined. The objective of this research was to develop a method of evaluating potential shallow-land burial waste disposal sites by interpreting tracer breakthrough curve structure with respect to the hydrologic properties of the media at the potential disposal site. This methodology will be helpful in evaluating the potential performance of many types of shallow-land waste burial sites such as low-level radioactive waste disposal, surface disposal of flyash, chemical waste disposal, waste sedimentation ponds, and sanitary landfills

  15. Tracer Flux Balance at an Urban Canyon Intersection

    Science.gov (United States)

    Carpentieri, Matteo; Robins, Alan G.

    2010-05-01

    Despite their importance for pollutant dispersion in urban areas, the special features of dispersion at street intersections are rarely taken into account by operational air quality models. Several previous studies have demonstrated the complex flow patterns that occur at street intersections, even with simple geometry. This study presents results from wind-tunnel experiments on a reduced scale model of a complex but realistic urban intersection, located in central London. Tracer concentration measurements were used to derive three-dimensional maps of the concentration field within the intersection. In combination with a previous study (Carpentieri et al., Boundary-Layer Meteorol 133:277-296, 2009) where the velocity field was measured in the same model, a methodology for the calculation of the mean tracer flux balance at the intersection was developed and applied. The calculation highlighted several limitations of current state-of-the-art canyon dispersion models, arising mainly from the complex geometry of the intersection. Despite its limitations, the proposed methodology could be further developed in order to derive, assess and implement street intersection dispersion models for complex urban areas.

  16. Atlantic Coast Unique Regional Atmospheric Tracer Experiment (ACURATE)

    International Nuclear Information System (INIS)

    Schubert, J.F.; Heffter, J.L.; Mead, G.A.

    1983-05-01

    The Atlantic Coast Unique Regional Atmospheric Tracer Experiment (ACURATE) is a program designed to obtain data necessary to evaluate atmospheric transport and diffusion models used to calculate regional population doses caused by nuclear facility emissions to the atmosphere. This experiment will significantly improve the basis for evaluating the cost effectiveness of different methods of managing airborne nuclear wastes. During the period from March 1982 through September 1982, twice daily air samples have been collected at each of five sampling stations located on a radial from the SRP to Murray Hill, NJ (1000 km). Kr-85 emitted from the F and H area chemical separations facilities is being used as a tracer to determine the transport and diffusion of atmospheric releases from the SRP. The Kr-85 concentrations in the air samples will be compared with the calculated concentrations as predicted by the transport and diffusion models. The Kr-85 data and the meteorological data are being archived and will be made available to the modeling community

  17. Tracer dispersion in two-dimensional rough fractures.

    Science.gov (United States)

    Drazer, G; Koplik, J

    2001-05-01

    Tracer diffusion and hydrodynamic dispersion in two-dimensional fractures with self-affine roughness are studied by analytic and numerical methods. Numerical simulations were performed via the lattice-Boltzmann approach, using a boundary condition for tracer particles that improves the accuracy of the method. The reduction in the diffusive transport, due to the fractal geometry of the fracture surfaces, is analyzed for different fracture apertures. In the limit of small aperture fluctuations we derive the correction to the diffusive coefficient in terms of the tortuosity, which accounts for the irregular geometry of the fractures. Dispersion is studied when the two fracture surfaces are simply displaced normally to the mean fracture plane and when there is a lateral shift as well. Numerical results are analyzed using the Lambda parameter, related to convective transport within the fracture, and simple arguments based on lubrication approximation. At very low Péclet number, in the case where fracture surfaces are laterally shifted, we show using several different methods that convective transport reduces dispersion.

  18. Spectrally adapted red flare tracers with superior spectral performance

    Directory of Open Access Journals (Sweden)

    Ramy Sadek

    2017-12-01

    Full Text Available The production of bright light, with vivid color, is the primary purpose of signaling, illuminating devices, and fire control purposes. This study, reports on the development of red flame compositions with enhanced performance in terms of luminous intensity, and color quality. The light intensity and the imprint spectra of developed red flame compositions to standard NATO red tracer (R-284 NATO were measured using digital luxmeter, and UV–Vis. spectrometer. The main giving of this study is that the light intensity of standard NATO red tracer was increased by 72%, the color quality was also improved by 60% (over the red band from 650 to 780 nm. This enhanced spectral performance was achieved by means of deriving the combustion process to maximize the formation of red color emitting species in the combustion flame. Thanks to the optimum ratio of color source to color intensifier using aluminum metal fuel; this approach offered the highest intensity and color quality. Upon combustion, aluminum was found to maximize the formation SrCL (the main reactive red color emitting species and to minimize the interfering incandescent emission resulted from MgO and SrO. Quantification of active red color emitting species in the combustion flame was conducted using chemical equilibrium thermodynamic code named ICT. The improvement in red flare performance, established the rule that the color intensifier should be in the range from 10 to 15 Wt % of the total composition.

  19. Tracers discrimination of sediment provenience in rural catchment through EDXRF

    Energy Technology Data Exchange (ETDEWEB)

    Melquiades, Fabio L. [Universidade Estadual do Centro Oeste (UNICENTRO), Guarapuava, PR (Brazil). Dept. de Fisica; Thomaz, Edivaldo L. [Universidade Estadual do Centro Oeste (UNICENTRO), Guarapuava, PR (Brazil). Dept. de Geografia

    2010-07-01

    Full text: Sediment dynamics understanding in a drainage system is fundamental for soil and water conservation at hydro graphic basins. This work aim was to discriminate sediment provenance tracers in rural basin. Sediment samples from different points in the headwater (road, forest, riverbank, river sediment deposit) were collected. Energy Dispersive X-ray Fluorescence (EDXRF) was the analytical technique applied, which was efficient to detect the chemical composition of the sediments. The samples were dried for 48h at 50 deg C, ground and sieved for granulometry 1mm. In natura samples (3 g) were placed in cells covered with mylar film for irradiation. Titanium, Mn, Fe, Cu, Zn, Y and Zr were identified. It was concluded that the elements, when analyzed individually or paired, do not allow a clear environment distinction except for yttrium (Y) that indicates distinct characteristics between the riverbank materials related to the other environments. However, the cluster analysis provided discrimination between the different sources of sediment. Also, it was verified that the recent deposited sediment in the river channel displays greater similarity with the materials of the road than with the riverbank. It is probable that the roads has been the mainly sediment source in the studied headwater. The methodology is innovative for tracer determination in soil and erosion quantification. (author)

  20. Tracers discrimination of sediment provenience in rural catchment through EDXRF

    International Nuclear Information System (INIS)

    Melquiades, Fabio L.; Thomaz, Edivaldo L.

    2010-01-01

    Full text: Sediment dynamics understanding in a drainage system is fundamental for soil and water conservation at hydro graphic basins. This work aim was to discriminate sediment provenance tracers in rural basin. Sediment samples from different points in the headwater (road, forest, riverbank, river sediment deposit) were collected. Energy Dispersive X-ray Fluorescence (EDXRF) was the analytical technique applied, which was efficient to detect the chemical composition of the sediments. The samples were dried for 48h at 50 deg C, ground and sieved for granulometry 1mm. In natura samples (3 g) were placed in cells covered with mylar film for irradiation. Titanium, Mn, Fe, Cu, Zn, Y and Zr were identified. It was concluded that the elements, when analyzed individually or paired, do not allow a clear environment distinction except for yttrium (Y) that indicates distinct characteristics between the riverbank materials related to the other environments. However, the cluster analysis provided discrimination between the different sources of sediment. Also, it was verified that the recent deposited sediment in the river channel displays greater similarity with the materials of the road than with the riverbank. It is probable that the roads has been the mainly sediment source in the studied headwater. The methodology is innovative for tracer determination in soil and erosion quantification. (author)