Phosphors

International Nuclear Information System (INIS)

1975-01-01

This invention relates to phosphors that can be used in fluorescent lamps and display devices. The phosphor is comprised of a halophosphate of calcium and/or strontium of apatite crystal structure activated with trivalent cerium and trivalent terbium. The phosphor can further include manganese. Preferably, the phosphor includes up to 10% by weight of one or more of the alkali metals lithium, sodium and potassium in the form of a compound or compounds thereof. The emissions appear as a number of fairly narrow discrete bands. The temperature of preparation is 1000degC (as opposed to the usual 1450degC), therefore reducing costs (less energy is needed, more crucibles are readily obtainable and there is no need for special conditions to enable crucibles to overcome thermal shock)

Catalytic oxidation of methanol on Pt/X (X = CaTP, NaTP electrodes in sulfuric acid solution

Directory of Open Access Journals (Sweden)

Said Benmokhtar

2013-10-01

Full Text Available In this paper, we report the synthesis and characterization of electrodes based on NASICON type phosphates. The study of the electrochemical oxidation of methanol at ambient temperature on electrodes based on NASICON type Ca0,5Ti2(PO43 (CaTP and Na5Ti(PO43 (NaTP compared to that of the platinum electrode model has been conducted by cyclic voltammetry in acidic medium. The results showed a significant increase of current density on the electro oxidation of methanol on the material developed based NASICON structure CaTP, cons deactivation of the electro oxidation is observed the closed structure type NaTP.

Fundamentals of phosphors

CERN Document Server

Yen, William M; Yamamoto, Hajime

2006-01-01

Drawing from the second edition of the best-selling Handbook of Phosphors, Fundamentals of Phosphors covers the principles and mechanisms of luminescence in detail and surveys the primary phosphor materials as well as their optical properties. The book addresses cutting-edge developments in phosphor science and technology including oxynitride phosphors and the impact of lanthanide level location on phosphor performance.Beginning with an explanation of the physics underlying luminescence mechanisms in solids, the book goes on to interpret various luminescence phenomena in inorganic and organic materials. This includes the interpretation of the luminescence of recently developed low-dimensional systems, such as quantum wells and dots. The book also discusses the excitation mechanisms by cathode-ray and ionizing radiation and by electric fields to produce electroluminescence. The book classifies phosphor materials according to the type of luminescence centers employed or the class of host materials used and inte...

Practical applications of phosphors

CERN Document Server

Yen, William M; Yamamoto, Hajime

2006-01-01

Drawn from the second edition of the best-selling Phosphor Handbook, Practical Applications of Phosphors outlines methods for the production of various phosphors and discusses a broad spectrum of applications. Beginning with methods for synthesis and related technologies, the book sets the stage by classifying and then explaining practical phosphors according to usage. It describes the operating principle and structure of phosphor devices and the phosphor characteristics required for a given device, then covers the manufacturing processes and characteristics of phosphors. The book discusses research and development currently under way on phosphors with potential for practical usage and touches briefly on phosphors that have played a historical role, but are no longer of practical use. It provides a comprehensive treatment of applications including lamps and cathode-ray tubes, x-ray and ionizing radiation, and for vacuum fluorescent and field emission displays and covers inorganic and organic electroluminescen...

Thermoluminescent phosphor

Science.gov (United States)

Lasky, Jerome B.; Moran, Paul R.

1978-01-01

A thermoluminescent phosphor comprising LiF doped with boron and magnesium is produced by diffusion of boron into a conventional LiF phosphor doped with magnesium. Where the boron dopant is made to penetrate only the outer layer of the phosphor, it can be used to detect shallowly penetrating radiation such as tritium beta rays in the presence of a background of more penetrating radiation.

Rare earth phosphors and phosphor screens

International Nuclear Information System (INIS)

Buchanan, R.A.; Maple, T.G.; Sklensky, A.F.

1981-01-01

Advances in the use of stabilized rare earth phosphors and of conversion screens using these materials are examined. In particular the new phosphors discussed in this invention consist of oxybromides of yttrium, lanthanum and gadolinium with a luminescent activator ion stabilized by an oxychloride or oxyfluoride surface layer and the conversion screens include trivalent cerium as the activator ion. (U.K.)

TP53 Mutations in Nonsmall Cell Lung Cancer

Directory of Open Access Journals (Sweden)

Akira Mogi

2011-01-01

Full Text Available The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells. Human lung cancers are classified into two major types, small cell lung cancer (SCLC and nonsmall cell lung cancer (NSCLC. The latter accounts for approximately 80% of all primary lung cancers, and the incidence of NSCLC is increasing yearly. Most clinical studies suggest that NSCLC with TP53 alterations carries a worse prognosis and may be relatively more resistant to chemotherapy and radiation. A deep understanding of the role of TP53 in lung carcinogenesis may lead to a more reasonably targeted clinical approach, which should be exploited to enhance the survival rates of patients with lung cancer. This paper will focus on the role of TP53 in the molecular pathogenesis, epidemiology, and therapeutic strategies of TP53 mutation in NSCLC.

Study of the Antimicrobial Activity of Tilapia Piscidin 3 (TP3) and TP4 and Their Effects on Immune Functions in Hybrid Tilapia (Oreochromis spp.)

Science.gov (United States)

Pan, Chieh-Yu; Tsai, Tsung-Yu; Su, Bor-Chyuan; Hui, Cho-Fat; Chen, Jyh-Yih

2017-01-01

To address the growing concern over antibiotic-resistant microbial infections in aquatic animals, we tested several promising alternative agents that have emerged as new drug candidates. Specifically, the tilapia piscidins are a group of peptides that possess antimicrobial, wound-healing, and antitumor functions. In this study, we focused on tilapia piscidin 3 (TP3) and TP4, which are peptides derived from Oreochromis niloticus, and investigated their inhibition of acute bacterial infections by infecting hybrid tilapia (Oreochromis spp.) with Vibrio vulnificus and evaluating the protective effects of pre-treating, co-treating, and post-treating fish with TP3 and TP4. In vivo experiments showed that co-treatment with V. vulnificus and TP3 (20 μg/fish) or TP4 (20 μg/fish) achieved 95.3% and 88.9% survival rates, respectively, after seven days. When we co-injected TP3 or TP4 and V. vulnificus into tilapia and then re-challenged the fish with V. vulnificus after 28 days, the tilapia exhibited survival rates of 35.6% and 42.2%, respectively. Pre-treatment with TP3 (30 μg/fish) or TP4 (20 μg/fish) for 30 minutes prior to V. vulnificus infection resulted in high survival rates of 28.9% and 37.8%, respectively, while post-treatment with TP3 (20 μg/fish or 30 μg/fish) or TP4 (20 μg/fish) 30 minutes after V. vulnificus infection yielded high survival rates of 33.3% and 48.9%. In summary, pre-treating, co-treating, and post-treating fish with TP3 or TP4 all effectively decreased the number of V. vulnificus bacteria and promoted significantly lower mortality rates in tilapia. The minimum inhibitory concentrations (MICs) of TP3 and TP4 that were effective for treating fish infected with V. vulnificus were 7.8 and 62.5 μg/ml, respectively, whereas the MICs of kanamycin and ampicillin were 31.2 and 3.91 μg/ml. The antimicrobial activity of these peptides was confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM), both of which showed

Experimental manipulation of TN:TP ratiossuppress cyanobacterial biovolume and microcystinconcentration in large-scale in situ mesocosms

Science.gov (United States)

Harris, Theodore D.; Wilhelm, Frank M.; Graham, Jennifer L.; Loftin, Keith A.

2014-01-01

A global dataset was compiled to examine relations between the total nitrogen to total phosphorus ratio (TN:TP) and microcystin concentration in lakes and reservoirs. Microcystin concentration decreased as TN:TP ratios increased, suggesting that manipulation of the TN:TP ratio may reduce microcystin concentrations. This relationship was experimentally tested by adding ammonium nitrate to increase the TN:TP ratio in large-scale (70 m3), in situ mesocosms located in a eutrophic reservoir that routinely experiences toxic blooms of cyanobacteria. At a TN:TP ratio >75:1, chlorophytes dominated the phytoplankton community in the mesocosms, while cyanobacterial biovolume was significantly reduced and microcystin was not detected. In contrast, the unmanipulated reservoir was dominated by cyanobacteria, and microcystin was detected. Secchi depths were 1.1 to 1.8 times greater in the mesocosms relative to the reservoir. Cladoceran zooplankton had a larger body size (0.14 mm on average) in the mesocosms compared to conspecifics in the reservoir, which was likely related to the higher quality food. Combined, these empirical and experimental data indicate that although nutrient addition is counterintuitive to current cyanobacteria management practices, increasing the TN:TP ratio by adding nitrogen may be a potential short-term management strategy to reduce cyanobacteria and cyanotoxins when other alternatives (e.g., phosphorus reduction) are not possible. Additional experimental studies with careful controls are needed to define best management practices and identify any potential unintended consequences before nitrogen addition is implemented as a lake and reservoir management practice.

Oxidizer in phosphoric reactors

International Nuclear Information System (INIS)

Santos Benedetto, J. dos

1985-01-01

Oxidation during the manufacture of wet-process phosphoric acid affected the distribution of uranium and impurities between phosphoric acid and gypsum, by decreasing the uranium loss to gypsum and the impurities solubilization in phosphoric acid. (Author) [pt

TP53 dysfunction in CLL: Implications for prognosis and treatment.

Science.gov (United States)

Te Raa, Gera D; Kater, Arnon P

2016-03-01

Despite the availability of novel targeted agents, TP53 defects remain the most important adverse prognostic factor in chronic lymphocytic leukemia (CLL). Detection of deletion of TP53 locus (17p deletion) by fluorescent in situ hybridization (FISH) has become standard and performed prior to every line of treatment as the incidence dramatically increases as relapses occur. As monoallelic mutations of TP53 equally affect outcome, novel methods are being developed to improve detection of TP53 defects and include next-generation sequencing (NGS) and functional assays. TP53 defects highly affect outcome of immunochemotherapy but also alter response durations of tyrosine kinase inhibitors. Although BCR-targeting agents and Bcl-2-inhibitos have achieved durable responses in some patients with TP53 defects, long-term follow-up is currently lacking. In this review biological and clinical consequences of TP53 dysfunction as well as applicability of currently available methods to detect TP53 defects are described. In addition, proposed novel therapeutic strategies specifically for patients with TP53 dysfunction are discussed. In summary, the only curative treatment option for TP53-defective CLL is still allogeneic hematopoietic stem cell transplantation. Other treatment strategies such as rationale combinations of agents with different (TP53 independent) targets, including kinase inhibitors and inhibitors of anti-apoptotic molecules but also immunomodulatory agents need to be further explored. Copyright © 2016 Elsevier Ltd. All rights reserved.

Phosphors for LED lamps

Science.gov (United States)

Murphy, James Edward; Manepalli, Satya Kishore; Kumar, Prasanth Nammalwar

2013-08-13

A phosphor, a phosphor blend including the phosphor, a phosphor prepared by a process, and a lighting apparatus including the phosphor blend are disclosed. The phosphor has the formula (Ca.sub.1-p-qCe.sub.pK.sub.q).sub.xSc.sub.y(Si.sub.1-rGa.sub.r).sub.zO.su- b.12+.delta. or derived from a process followed using disclosed amounts of reactants. In the formula, (0

Antioxidant activity, total phenolic, and total flavonoid of extracts from stems of Jasminum nervosum Lour

Directory of Open Access Journals (Sweden)

Wei, Xiangyong

2011-06-01

Full Text Available Guangxi traditional Chinese Medical University Universidad de Medicina Tradicional China de Guangxi This study evaluated the antioxidant activities of the extracts of Jasminum nervosum Lour. stems along with the effects of different extract solvents on total phenolics (TP, total flavonoids (TF, and antioxidant potential. The antioxidant activity of the extracts was assessed using the following methods: DPPH, ABTS+ both free radicals scavenging assays, and reducing assays. TP and TF were detected by spectrophotometric and HPLC methods. In former methods, the highest amount of TP content was ethy lacetate extract (EAE, expressed as gallic acid equivalents. The greatest TF content was in the n-butanol extract (BE, expressed as lutin equivalents. No significant difference was observed in the TP/TF content between these two extracts. The antioxidant activity and TP/TF content of three extracts seemed to follow the same trend. This implied that there is a good correlation between antioxidant activities and TP/TF content. But in HPLC methods, EAE contained the highest content of lutin and gallic acid, which decreased in the same order of EAE > BE > PE, the rank order of TP/TF content of EAE and BE were different according to antioxidant ability. The overall results showed that the EAE and BE were richer in phenolics and flavonoids than petroleum ether extract (PE, and may represent a good source of antioxidants.Este estudio evaluó las actividades antioxidantes de extractos de tallos de Jasminum nervosum Lour., y el efecto de diferentes disolventes de extracción en los fenoles totales (TP y flavonoides totales (TF, y su potencial antioxidante. La actividad antioxidante de los extractos fue evaluada usando los siguientes métodos: DPPH, ABTS+ y ensayos reductores. TP y TF fueron detectados por métodos espectroscópicos y por HPLC. Con el primer método, el contenido más alto de TP se obtuvo en el extracto con acetato de etilo (EAE, expresado como

Phosphor scintillator structure

International Nuclear Information System (INIS)

Cusano, D.A.; Prener, J.S.

1980-01-01

A method of fabricating scintillators is described in which the phosphor is distributed within the structure in such a way as to enhance the escape of the visible wavelength radiation that would otherwise be dissipated within the scintillator body. Two embodiments of the present invention are disclosed: one in which the phosphor is distributed in a layered structure and another in which the phosphor is dispersed throughout a transparent matrix. (U.K.)

Structure and molecular assignment of lactococcal phage TP901-1 baseplate

DEFF Research Database (Denmark)

Bebeacua, Cecilia; Bron, Patrick; Lai, Livia

2010-01-01

on the host cell surface. We report here the electron microscopic structure of the phage TP901-1 wild-type BP as well as those of two mutants bppL (-) and bppU(-), lacking BppL (the RBPs) or both peripheral BP components (BppL and BppU), respectively. We also achieved an electron microscopic reconstruction...... of a partial BP complex, formed by BppU and BppL. This complex exhibits a tripod shape and is composed of nine BppLs and three BppUs. These structures, combined with light-scattering measurements, led us to propose that the TP901-1 BP harbors six tripods at its periphery, located around the central tube formed...... by ORF46 (Dit) hexamers, at its proximal end, and a ORF47 (Tal) trimer at its distal extremity. A total of 54 BppLs (18 RBPs) are thus available to mediate host anchoring with a large apparent avidity. TP901-1 BP exhibits an infection-ready conformation and differs strikingly from the lactococcal phage p...

Overexpressed TP73 induces apoptosis in medulloblastoma

International Nuclear Information System (INIS)

Castellino, Robert C; De Bortoli, Massimiliano; Lin, Linda L; Skapura, Darlene G; Rajan, Jessen A; Adesina, Adekunle M; Perlaky, Laszlo; Irwin, Meredith S; Kim, John YH

2007-01-01

Medulloblastoma is the most common malignant brain tumor of childhood. Children who relapse usually die of their disease, which reflects resistance to radiation and/or chemotherapy. Improvements in outcome require a better understanding of the molecular basis of medulloblastoma growth and treatment response. TP73 is a member of the TP53 tumor suppressor gene family that has been found to be overexpressed in a variety of tumors and mediates apoptotic responses to genotoxic stress. In this study, we assessed expression of TP73 RNA species in patient tumor specimens and in medulloblastoma cell lines, and manipulated expression of full-length TAp73 and amino-terminal truncated ΔNp73 to assess their effects on growth. We analyzed medulloblastoma samples from thirty-four pediatric patients and the established medulloblastoma cell lines, Daoy and D283MED, for expression of TP73 RNA including the full-length transcript and the 5'-terminal variants that encode the ΔNp73 isoform, as well as TP53 RNA using quantitative real time-RTPCR. Protein expression of TAp73 and ΔNp73 was quantitated with immunoblotting methods. Clinical outcome was analyzed based on TP73 RNA and p53 protein expression. To determine effects of overexpression or knock-down of TAp73 and ΔNp73 on cell cycle and apoptosis, we analyzed transiently transfected medulloblastoma cell lines with flow cytometric and TUNEL methods. Patient medulloblastoma samples and cell lines expressed full-length and 5'-terminal variant TP73 RNA species in 100-fold excess compared to non-neoplastic brain controls. Western immunoblot analysis confirmed their elevated levels of TAp73 and amino-terminal truncated ΔNp73 proteins. Kaplan-Meier analysis revealed trends toward favorable overall and progression-free survival of patients whose tumors display TAp73 RNA overexpression. Overexpression of TAp73 or ΔNp73 induced apoptosis under basal growth conditions in vitro and sensitized them to cell death in response to

Overexpressed TP73 induces apoptosis in medulloblastoma

Directory of Open Access Journals (Sweden)

Perlaky Laszlo

2007-07-01

Full Text Available Abstract Background Medulloblastoma is the most common malignant brain tumor of childhood. Children who relapse usually die of their disease, which reflects resistance to radiation and/or chemotherapy. Improvements in outcome require a better understanding of the molecular basis of medulloblastoma growth and treatment response. TP73 is a member of the TP53 tumor suppressor gene family that has been found to be overexpressed in a variety of tumors and mediates apoptotic responses to genotoxic stress. In this study, we assessed expression of TP73 RNA species in patient tumor specimens and in medulloblastoma cell lines, and manipulated expression of full-length TAp73 and amino-terminal truncated ΔNp73 to assess their effects on growth. Methods We analyzed medulloblastoma samples from thirty-four pediatric patients and the established medulloblastoma cell lines, Daoy and D283MED, for expression of TP73 RNA including the full-length transcript and the 5'-terminal variants that encode the ΔNp73 isoform, as well as TP53 RNA using quantitative real time-RTPCR. Protein expression of TAp73 and ΔNp73 was quantitated with immunoblotting methods. Clinical outcome was analyzed based on TP73 RNA and p53 protein expression. To determine effects of overexpression or knock-down of TAp73 and ΔNp73 on cell cycle and apoptosis, we analyzed transiently transfected medulloblastoma cell lines with flow cytometric and TUNEL methods. Results Patient medulloblastoma samples and cell lines expressed full-length and 5'-terminal variant TP73 RNA species in 100-fold excess compared to non-neoplastic brain controls. Western immunoblot analysis confirmed their elevated levels of TAp73 and amino-terminal truncated ΔNp73 proteins. Kaplan-Meier analysis revealed trends toward favorable overall and progression-free survival of patients whose tumors display TAp73 RNA overexpression. Overexpression of TAp73 or ΔNp73 induced apoptosis under basal growth conditions in vitro and

TP53 gene status affects survival in advanced mycosis fungoides

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Gitte Wooler

2016-11-01

Full Text Available TP53 is frequently mutated in different types of neoplasms including leukemia and lymphomas. Mutations of TP53 have also been reported in mycosis fungoides (MF, the most common type of cutaneous lymphoma. However, little is known about the frequency, spectrum of mutations and their prognostic significance in MF. In this study we have optimized the protocol for Sanger sequencing of TP53 using DNA extracted from archival paraffin-embedded biopsies. Of 19 samples from patients with stage IIB MF or higher, 31% harboured mutations in TP53. Overall survival of the patients with mutated TP53 was significantly shorter than median survival in the age- and stage-matched patients treated in our Institution. Distribution of mutations was heterogenous in TP53 exons, however C>T transitions were common suggesting the causal role of ultraviolet radiation. We propose that TP53 mutation status would be useful for risk stratification of patients with advanced MF.

Electron-beam-pumped phosphors

International Nuclear Information System (INIS)

Goldhar, J.; Krupke, W.F.

1985-01-01

Electron-beam excitation of solid-state scintillators, or phosphors, can result in efficient generation of visible light confined to relatively narrow regions of the spectrum. The conversion efficiency can exceed 20%, and, with proper choice of phosphors, radiation can be obtained anywhere from the near infrared (IR) to the near ultraviolet (UV). These properties qualify the phosphors as a potentially useful pump source for new solid-state lasers. New phosphors are being developed for high-brightness television tubes that are capable of higher power dissipation. Here, an epitaxial film of fluorescing material is grown on a crystalline substrate with good thermal properties. For example, researchers at North American Philips Laboratories have developed a cerium-doped yttrium aluminum garnet (YAG) grown on a YAG substrate, which has operated at 1 A/cm 2 at 20 kV without observed thermal quenching. The input power is higher by almost two orders of magnitude than that which can be tolerated by a conventional television phosphor. The authors describe tests of these new phosphors

High temperature thermometric phosphors

Science.gov (United States)

Allison, Stephen W.; Cates, Michael R.; Boatner, Lynn A.; Gillies, George T.

1999-03-23

A high temperature phosphor consists essentially of a material having the general formula LuPO.sub.4 :Dy.sub.(x),Eu.sub.y) wherein: 0.1 wt %.ltoreq.x.ltoreq.20 wt % and 0.1 wt %.ltoreq.y.ltoreq.20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopent. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions.

Spatial Variation of Phosphorous Retention Capacity in Subsurface Flow Constructed Wetlands: Effect of Wetland Type and Inflow Loading.

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Guangwei Yu

Full Text Available For verification of spatial distribution of phosphorous retention capacity in constructed wetlands systems(CWs, two horizontal subsurface flow(HSSF CWs and two vertical subsurface flow(VSSF CWs, using sand as substrate and Typha latifolia as wetland plants, were constructed and put into use for synthetic wastewater treatment. Five months later, significant spatial variations of TP and inorganic phosphorus(Ca-P, Fe-P and Al-P were observed, which were found to be greatly affected by CWs type and hydraulic loading. The results revealed that though spatial distribution of Fe-P and Al-P displayed a similar order of substrate content as "rhizosphere" > "near-rhizosphere" > "non-rhizosphere" and "inflow section" > "outflow section" regardless of types and loading, the distribution of Ca-P was positively correlated to that of Fe-P and Al-P in HSSF CWs, while negative correlation was shown in VSSF CWs. As a result, TP spatial distribution in HSSF CWs demonstrated a greater dissimilarity than that in VSSF CWs. For HSSF CWs with low hydraulic loading, the lowest TP content was found in non-rhizosphere substrate of outflow section, while the highest one was discovered in rhizonsphere substrate of inflow section. The values in 6 parts of areas ranged from 0.138 g·kg-1 to 2.710 g·kg-1, which also were from -33.5% to 1209% compared to the control value. On contrast, spatial difference of TP content in substrates of VSSF CWs was insignificant, with a variation ranging from 0.776 g·kg-1 to 1.080 g·kg-1, that was 275% to 421% higher than the control value. In addition, when hydraulic loading was increased, TP content in VSSF CWs sharply decreased, ranging from 0.210 g·kg-1 to 0.634 g·kg-1. Meanwhile, dissimilarity of TP spatial distribution in HSSF CWs was reduced, with TP content ranging from 0.258 g·kg-1 to 2.237 g·kg-1. The results suggested that P spatial distribution should be taken into account for CWs design and operation.

Prolonged Tp-e Interval in Down Syndrome Patients with Congenitally Normal Hearts.

Science.gov (United States)

Kucuk, Mehmet; Karadeniz, Cem; Ozdemir, Rahmi; Meşe, Timur

2018-03-25

Heterogeneity of ventricular repolarization has been assessed by using the QT dispersion in Down syndrome (DS) patients with congenitally normal hearts. However, novel repolarization indexes, the Tp-e interval and Tp-e/QT ratio, have not previously been evaluated in these patients. The aim of this study was to evaluate the Tp-e interval and Tp-e/QT ratio in DS patients without congenital heart defects. Twelve-lead surface electrocardiograms of 160 DS patients and 110 age- and sex-matched healthy controls were used to evaluate and compare the Tp-e interval, Tp-e dispersion, and Tp-e/QT ratio. Heart rate, Tp-e interval, Tp-e dispersion, Tp-e/QT and Tp-e/QTc ratios were significantly higher in DS group than in the controls. Myocardial repolarization indexes in DS patients with congenitally normal hearts were found to be prolonged compared to those in normal controls. Further evaluation is warranted to reveal a relationship between prolonged repolarization indexes and arrhythmic events in these patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The IARC TP53 mutation database: a resource for studying the significance of TP53 mutations in human cancers

Directory of Open Access Journals (Sweden)

Magali Olivier

2007-02-01

yeast and human cells to measure the impact of these mutations on various protein properties: (1 transactivation activities (TA of mutant proteins on reporter genes placed under the control of various p53 responseelements, (2 capacity of mutant proteins to induce cellcycle arrest or apoptosis, (3 ability to exert dominantnegative effect (DNE over the wild-type protein, (4 activities of mutant proteins that are independent and unrelated to the wild-type protein (gain of function, GOF. Prediction models based on interspecies protein sequence conservation have also been developed to predict the functional impact of all possible single amino-acid substitutions.

These data have been used to produce systematic functional classifications of mutant proteins and these classifications have been integrated in the IARC TP53 database. New tools have been implemented to visualize these data and analyze mutation frequencies in relation to their functional impact and intrinsic nucleotide substitution rates.

Thus, the database allows systematic analyses of the factors that shape the patterns and influence the phenotype of missense mutations in human cancers. In a recent analysis of the database, we showed that that loss of TA capacity is a key factor for the selection of missense mutations, and that difference in mutation frequencies is closely related to nucleotide substitution rates along TP53 coding sequence. TA capacity of inherited missense mutations was also found to be related the age at onset of specific tumor types, mutations with total loss of TA being associated with earlier cancer onset cancers compared to mutations that retain partial trans-activation capacity. Furthermore, 80% of the most common mutants show a capacity to exert dominant-negative effect (DNE over wildtype p53, compared to only 45% of

Ultraviolet dosimetry using thermoluminescent phosphors - an update

International Nuclear Information System (INIS)

Nagpal, J.S.

1998-04-01

Intrinsic response of various thermoluminescent (TL) materials such as CaSO 4 (Dy, Eu, Mn, Sm, Tb, or Tm), LiF (Mg, Cu, P), Mg 2 SiO 4 :Tb, CaF 2 :Dy, CaF 2 :Tb, ThO 2 :Tb and Al 2 O 3 (Si, Ti); cathodoluminescent phosphors Y 3 Al 5 O 12 :Ce, Y 3 Al 5 O 12 :Tb and Y(V,P)O 4 :Eu; and fluorescent lamp phosphors calcium halophosphate (Mn,Sb) and Ce Mg aluminate (Eu, Tb) to ultraviolet (UV) radiations has been studied. Intrinsic TL response of most of the phosphors is rate (radiant flux) dependent. For the first time, UV response of the materials is reported for a fixed total radiant energy (total UV dose), at a single radiant flux (260 μW.cm -2 ), for an appropriate comparison. A wide range of UV sensitivity is observed. Studies conducted using UV radiation from two unfiltered low pressure mercury lamps show significant differences in glow curves, as compared to those obtained with nearly monochromatic UV radiations. Photons of wavelength 365 nm induce bleaching of TL induced by 254 nm photons, in most of the materials. Sequential/tandem exposures to 254 nm and 365 nm photons have yielded new but alarming results in CaF 2 :Tb. Preferential induction and bleaching of specific TL glow peaks by 365 nm and 254 nm photons are interesting characteristics discovered in CaSO 4 :Eu. Photoluminescence studies of Tb 3+ and Eu 3+ activated phosphors have augmented the inferences drawn from the bleaching effects produced by 365 nm photons. Earlier work carried out on phototransferred thermoluminescence of CaSO 4 :Dy-teflon dosimeters, TLD-100, Mg 2 SiO 4 :Tb and Al 2 O 3 (Si,Ti) has also been reviewed. (author)

Main - TP Atlas | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...me: tp_atlas_en.zip File URL: ftp://ftp.biosciencedbc.jp/archive/tp_atlas/LATEST/...d License Update History of This Database Site Policy | Contact Us Main - TP Atlas | LSDB Archive ...

Unactivated yttrium tantalate phosphor

International Nuclear Information System (INIS)

Reddy, V.B.; Cheung, H.K.

1992-01-01

This patent describes an unactivated yttrium tantalate phosphor having M prime monoclinic structure and containing one or more additives of Rb and Al in an amount of between about 0.001 to 0.1 moles per mole of yttrium tantalate to improve brightness under X-radiation. This patent also describes an unactivated yttrium tantalate phosphor having M prime monoclinic structure and containing additives of Sr in an amount of between 0.001 to 0.1 moles per mole of yttrium tantalate and one or more of Rb and Al in an amount of between 0.001 to 0.1 moles per mole of yttrium tantalate the phosphor exhibiting a greater brightness under X-radiation than the phosphor absent Rb and Al

TP Organics - maheuuringute tehnoloogiaplatvorm

Index Scriptorium Estoniae

2015-01-01

TP Organics on 2008. a loodud Euroopa mahepõllumajanduse ja mahetoidu ning vähese sisendiga põllumajanduse tehnoloogiaplatvorm. Platvormi eesmärk on selgitada välja teadustöö ja uuenduste vajadused ning edastada see info poliitikutele

The influence of waterweeds in the removal of phosphor in content aquatic environments

Science.gov (United States)

Salamah, L. N.; Kurniawan, A.

2018-04-01

Over the last few decades phosphorus removal methods have increasingly been designed. One of the methods is using waterweed for uptake the phosphorus (P) from water and sediment. However, lack information of suitable waterweed for P removal. The goals of this research are to investigate the effect of waterweeds in the P removal and to find the suitable waterweeds for P removal. Five types of waterweeds (Phragmites australis, Egeria densa,, Bacupa myriophylloides, Eichornia crassipes, and Limnobium laevigatum) were collected and cultivated in pots. Water and sediment were collected from natural small pond, and sampling were perfomed at 0, 7, 14, 21 and 28 days. The result showed that P of water and sediment were reduced during the experiment. E. densa accumulated highest TP (505 mg/kg). It was suggested that E. densa is suitable for phosphor removal.

White light quality of phosphor converted light-emitting diodes: A phosphor materials perspective of view

International Nuclear Information System (INIS)

Sommer, Christian; Hartmann, Paul; Pachler, Peter; Hoschopf, Hans; Wenzl, Franz P.

2012-01-01

Highlights: ► We discuss the impact of the optical properties of a phosphor for colour temperature constancy in solid state lighting. ► Quantitative evaluation of permissible variations of the optical properties for batch-to-batch reproducibility. ► Quantitative evaluation of permissible variations of the optical properties upon temperature increase. ► Quantitative evaluation of permissible variations of the optical properties upon materials degradation. - Abstract: For a systematic approach to improve the white light quality of phosphor converted LEDs and to fulfil the demands for colour temperature reproducibility and constancy, it is imperative to understand how variations of the extinction coefficient and the quantum efficiency of the phosphor particles as well as variations of the excitation wavelength of the blue LED die affect the correlated colour temperature of the white LED source. Based on optical ray tracing of a phosphor converted white LED package we deduce permissible values for the variation of a given extinction coefficient and a given quantum efficiency of a phosphor material in order to maintain acceptable colour variations. These quantitative valuations of the required constancy of the optical properties of the phosphors will in particular provide some benchmarks for the synthesis of improved phosphor materials aiming at solid state lighting applications.

Analytical and clinical comparison of Elecsys syphilis (Roche®) - Architect syphilis TP and reformulated Architect syphilis TP (Abbott®) assay.

Science.gov (United States)

De Keukeleire, Steven; Desmet, Stefanie; Lagrou, Katrien; Oosterlynck, Julie; Verhulst, Manon; Van Besien, Jessica; Saegeman, Veroniek; Reynders, Marijke

2017-03-01

The performance of Elecsys Syphilis was compared to Architect Syphilis TP and Reformulated Architect Syphilis TP. The overall sensitivity and specificity were 98.4% and 99.5%, 97.7% and 97.1%, and 99.2% and 99.7% respectively. The assays are comparable and considered adequate for syphilis screening. Copyright © 2016 Elsevier Inc. All rights reserved.

Phosphor investigation in the production of Syrian phosphoric acid using Nuclear Magnetic Resonance

International Nuclear Information System (INIS)

Al-Hassanieh, O.; Al-Hameish, M.

2009-06-01

Nuclear magnetic resonance spectroscopy (NMR) was applied in this work to the industrial process of extraction of uranium from phosphoric acid and to the process of the purification of the phosphoric acid for food proposes. The structural changes of used extraction materials and the organic content of the final product was studied. 13 C , 1 H and 32 P-spectra of all material during the process were recorded. The spectra of the three used extraction materials Bis(2-ethylhexyl Phosphoric Acid)) DEHPA, TriOctyl Phosphine Oxide (TOPO) (C 8 H 1 7) 3 P=O and TriButyl Phosphate (TBP) (C 4 H 9 O) 3 P=O show a partial degradation during the process. The final product ( Phosphoric acid for Food proposes) doesn't contain any organic solvents or extraction material. (author)

Radioluminescent nuclear batteries with different phosphor layers

International Nuclear Information System (INIS)

Hong, Liang; Tang, Xiao-Bin; Xu, Zhi-Heng; Liu, Yun-Peng; Chen, Da

2014-01-01

Highlights: • We present and test the electrical properties of the nuclear battery. • The best thickness range for ZnS:Cu phosphor layer is 12–14 mg cm −2 for 147 Pm radioisotope. • The best thickness range for Y 2 O 2 S:Eu phosphor layer is 17–21 mg cm −2147 Pm radioisotope. • The battery with ZnS:Cu phosphor layer can provide higher energy conversion efficiency. • The mechanism affecting the nuclear battery output performance is revealed. - Abstract: A radioluminescent nuclear battery based on the beta radioluminescence of phosphors is presented, and which consists of 147 Pm radioisotope, phosphor layers, and GaAs photovoltaic cell. ZnS:Cu and Y 2 O 2 S:Eu phosphor layers for various thickness were fabricated. To investigate the effect of phosphor layer parameters on the battery, the electrical properties were measured. Results indicate that the optimal thickness ranges for the ZnS:Cu and Y 2 O 2 S:Eu phosphor layers are 12 mg cm −2 to 14 mg cm −2 and 17 mg cm −2 to 21 mg cm −2 , respectively. ZnS:Cu phosphor layer exhibits higher fluorescence efficiency compared with the Y 2 O 2 S:Eu phosphor layer. Its spectrum properly matches the spectral response of GaAs photovoltaic cell. As a result, the battery with ZnS:Cu phosphor layer indicates higher energy conversion efficiency than that with Y 2 O 2 S:Eu phosphor layer. Additionally, the mechanism of the phosphor layer parameters that influence the output performance of the battery is discussed through the Monte Carlo method and transmissivity test

Concentration and wavelength dependent frequency downshifting photoluminescence from a Tb3+ doped yttria nano-phosphor: A photochromic phosphor

Science.gov (United States)

Yadav, Ram Sagar; Rai, Shyam Bahadur

2018-03-01

In this article, the Tb3+ doped Y2O3 nano-phosphor has been synthesized through solution combustion method. The structural measurements of the nano-phosphor have been carried out by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques, which reveal nano-crystalline nature. The Fourier transform infrared (FTIR) measurements reveal the presence of different molecular species in the nano-phosphor. The UV-Vis-NIR absorption spectrum of the nano-phosphor shows large number of bands due to charge transfer band (CTB) and 4f-4f electronic transitions of Tb3+ ion. The Tb3+ doped Y2O3 nano-phosphor emits intense green downshifting photoluminescence centered at 543 nm due to 5D4 → 7F5 transition on excitation with 350 nm. The emission intensity of the nano-phosphor is optimized at 1.0 mol% concentration of Tb3+ ion. When the as-synthesized nano-phosphor is annealed at higher temperature the emission intensity of the nano-phosphor enhances upto 5 times. The enhancement in the emission intensity is due to an increase in crystallinity of the nano-phosphor, reduction in surface defects and optical quenching centers. The CIE diagram reveals that the Tb3+ doped nano-phosphor samples show the photochromic nature (color tunability) with a change in the concentration of Tb3+ ion and excitation wavelength. The lifetime measurement indicates an increase in the lifetime for the annealed sample. Thus, the Tb3+ doped Y2O3 nano-phosphor may be used in photochromic displays and photonic devices.

MULTI-PHOTON PHOSPHOR FEASIBILITY RESEARCH

Energy Technology Data Exchange (ETDEWEB)

R. Graham; W. Chow

2003-05-01

Development of multi-photon phosphor materials for discharge lamps represents a goal that would achieve up to a doubling of discharge (fluorescent) lamp efficacy. This report reviews the existing literature on multi-photon phosphors, identifies obstacles in developing such phosphors, and recommends directions for future research to address these obstacles. To critically examine issues involved in developing a multi-photon phosphor, the project brought together a team of experts from universities, national laboratories, and an industrial lamp manufacturer. Results and findings are organized into three categories: (1) Multi-Photon Systems and Processes, (2) Chemistry and Materials Issues, and (3) Concepts and Models. Multi-Photon Systems and Processes: This category focuses on how to use our current understanding of multi-photon phosphor systems to design new phosphor systems for application in fluorescent lamps. The quickest way to develop multi-photon lamp phosphors lies in finding sensitizer ions for Gd{sup 3+} and identifying activator ions to red shift the blue emission from Pr{sup 3+} due to the {sup 1}S{sub 0} {yields} {sup 1}I{sub 6} transition associated with the first cascading step. Success in either of these developments would lead to more efficient fluorescent lamps. Chemistry and Materials Issues: The most promising multi-photon phosphors are found in fluoride hosts. However, stability of fluorides in environments typically found in fluorescent lamps needs to be greatly improved. Experimental investigation of fluorides in actual lamp environments needs to be undertaken while working on oxide and oxyfluoride alternative systems for backup. Concepts and Models: Successful design of a multi-photon phosphor system based on cascading transitions of Gd{sup 3+} and Pr{sup 3+} depends critically on how the former can be sensitized and the latter can sensitize an activator ion. Methods to predict energy level diagrams and Judd-Ofelt parameters of multi

Phosphor blends for high-CRI fluorescent lamps

Science.gov (United States)

Setlur, Anant Achyut [Niskayuna, NY; Srivastava, Alok Mani [Niskayuna, NY; Comanzo, Holly Ann [Niskayuna, NY; Manivannan, Venkatesan [Clifton Park, NY; Beers, William Winder [Chesterland, OH; Toth, Katalin [Pomaz, HU; Balazs, Laszlo D [Budapest, HU

2008-06-24

A phosphor blend comprises at least two phosphors each selected from one of the groups of phosphors that absorb UV electromagnetic radiation and emit in a region of visible light. The phosphor blend can be applied to a discharge gas radiation source to produce light sources having high color rendering index. A phosphor blend is advantageously includes the phosphor (Tb,Y,LuLa,Gd).sub.x(Al,Ga).sub.yO.sub.12:Ce.sup.3+, wherein x is in the range from about 2.8 to and including 3 and y is in the range from about 4 to and including 5.

TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population

International Nuclear Information System (INIS)

Li, Yanli; Su, Jia; Cai, Lin; Yu, Shunzhang; Zhang, Zuo-Feng; Mu, Lina; Chang, Shen-Chih; Niu, Rungui; Liu, Li; Crabtree-Ide, Christina R; Zhao, Baoxing; Shi, Jianping; Han, Xiaoyou; Li, Jiawei

2013-01-01

A pathway-based genotyping analysis suggested rs2078486 was a novel TP53 SNP, but very few studies replicate this association. TP53 rs1042522 is the most commonly studied SNP, but very few studies examined its potential interaction with environmental factors in relation to lung cancer risk. This study aims to examine associations between two TP53 single-nucleotide polymorphisms (SNPs) (rs2078486, rs1042522), their potential interaction with environmental factors and risk of lung cancer. A case–control study was conducted in Taiyuan, China. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Multiplicative and additive interactions between TP53 SNPs and lifestyle factors were evaluated. Variant TP53 rs2078486 SNP was significantly associated with elevated lung cancer risk among smokers (OR: 1.70, 95% CI: 1.08 - 2.67) and individuals with high indoor air pollution exposure (OR: 1.51, 95% CI: 1.00-2.30). Significant or borderline significant multiplicative and additive interactions were found between TP53 rs2078486 polymorphism with smoking and indoor air pollution exposure. The variant genotype of TP53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors. This study confirmed that TP53 rs2078486 SNP is potentially a novel TP53 SNP that may affect lung cancer risk. Our study also suggested potential synergetic effects of TP53 rs2078486 SNP with smoking and indoor air pollution exposure on lung cancer risk

Effect of reciprocating agitation thermal processing (RA-TP) on quality of canned tomato (Solanum lycopersicum) puree.

Science.gov (United States)

Pratap Singh, Anubhav; Singh, Anika; Ramaswamy, Hosahalli S

2017-06-01

Reciprocating agitation thermal processing (RA-TP) is a recent innovation in the field of canning for obtaining high-quality canned food. The objective of this study was to compare RA-TP processing with conventional non-agitated (still) processing with respect to the impact on quality (color, antioxidant capacity, total phenols, carotenoid and lycopene contents) of canned tomato (Solanum lycopersicum) puree. Owing to a 63-81% reduction in process times as compared with still processing, tomato puree with a brighter red color (closer to fresh) was obtained during RA-TP. At 3 Hz reciprocation frequency, the loss of antioxidant, lycopene and carotenoid contents could be reduced to 34, 8 and 8% respectively as compared with 96, 41 and 52% respectively during still processing. In fact, the phenolic content for RA-TP at 3 Hz was 5% higher than in fresh puree. Quality retention generally increased with an increase in frequency, although the differences were less significant at higher reciprocation frequencies (between 2 and 3 Hz). Research findings indicate that RA-TP can be effective to obtain thermally processed foods with high-quality attribute retention. It can also be concluded that a very high reciprocation frequency (>3 Hz) is not necessarily needed and significant quality improvement can be obtained at lower frequencies (∼2 Hz). © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Technology of uranium recovery from wet-process phosphoric acid

Energy Technology Data Exchange (ETDEWEB)

Inoue, Katsutoshi [Saga Univ. (Japan). Faculty of Science and Engineering; Nakashio, Fumiyuki

1982-12-01

Rock phosphate contains from 0.005 to 0.02 wt.% of uranium. Though the content is a mere 5 to 10 % of that in uranium ore, the total recovery of uranium is significant since it is used for fertilizer manufacture in a large quantity. Wet-process phosphoric acid is produced by the reaction of rock phosphate with sulfuric acid. The recovery of uranium from this phosphoric acid is mostly by solvent extraction at present. According to U/sup 4 +/ or UO/sub 2//sup 2 +/ as the form of its existence, the technique of solvent extraction differs. The following matters are described: processing of rock phosphate; recovery techniques including the extraction by OPPA-octyl pyrophosphoric acid for U/sup 4 +/, and by mixed DEHPA-Di-(2)-ethylhexyl phosphoric acid and TOPO-tryoctyl phosphine oxide for UO/sub 2//sup 2 +/, and by OPAP-octylphenyl acid phosphate for U/sup 4 +/; the recent progress of the technology as seen in patents.

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.

Science.gov (United States)

Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H; Künkele, Annette

2017-04-25

Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40-70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. Reactivating TP53 functionality using small-molecule inhibitors, such as RITA, to disrupt TP53-MDM2 binding may have therapeutic potential. We show here that RITA decreased viability of all 4 analyzed medulloblastoma cell lines, regardless of TP53 functional status. The decrease in cell viability was accompanied in 3 of the 4 medulloblastoma cell lines by accumulation of TP53 protein in the cells and increased CDKN1A expression. RITA treatment in mouse models inhibited medulloblastoma xenograft tumor growth. These data demonstrate that RITA treatment reduces medulloblastoma cell viability in both in vitro and in vivo models, and acts independently of cellular TP53 status, identifying RITA as a potential therapeutic agent to treat medulloblastoma.

46 CFR 151.50-23 - Phosphoric acid.

Science.gov (United States)

2010-10-01

... 46 Shipping 5 2010-10-01 2010-10-01 false Phosphoric acid. 151.50-23 Section 151.50-23 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-23 Phosphoric acid. (a) The term phosphoric acid as used in this subpart shall include, in addition to phosphoric acid, aqueous solutions of...

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.

Science.gov (United States)

Zhukova, Nataliya; Ramaswamy, Vijay; Remke, Marc; Martin, Dianna C; Castelo-Branco, Pedro; Zhang, Cindy H; Fraser, Michael; Tse, Ken; Poon, Raymond; Shih, David J H; Baskin, Berivan; Ray, Peter N; Bouffet, Eric; Dirks, Peter; von Bueren, Andre O; Pfaff, Elke; Korshunov, Andrey; Jones, David T W; Northcott, Paul A; Kool, Marcel; Pugh, Trevor J; Pomeroy, Scott L; Cho, Yoon-Jae; Pietsch, Torsten; Gessi, Marco; Rutkowski, Stefan; Bognár, Laszlo; Cho, Byung-Kyu; Eberhart, Charles G; Conter, Cecile Faure; Fouladi, Maryam; French, Pim J; Grajkowska, Wieslawa A; Gupta, Nalin; Hauser, Peter; Jabado, Nada; Vasiljevic, Alexandre; Jung, Shin; Kim, Seung-Ki; Klekner, Almos; Kumabe, Toshihiro; Lach, Boleslaw; Leonard, Jeffrey R; Liau, Linda M; Massimi, Luca; Pollack, Ian F; Ra, Young Shin; Rubin, Joshua B; Van Meir, Erwin G; Wang, Kyu-Chang; Weiss, William A; Zitterbart, Karel; Bristow, Robert G; Alman, Benjamin; Hawkins, Cynthia E; Malkin, David; Clifford, Steven C; Pfister, Stefan M; Taylor, Michael D; Tabori, Uri

2014-12-24

TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6%±8.7%, respectively (p<0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89%±2% vs. 57.4%±1.8% (p<0.01)). In contrast, β-catenin mutation sensitized TP53 mutant cells to radiation (p<0.05). Lithium, an activator of the WNT pathway, sensitized TP53 mutant medulloblastoma to radiation (SF2 of 43.5%±1.5% in lithium treated cells vs. 56.6±3% (p<0.01)) accompanied by increased number of γH2AX foci. Normal neural stem cells were protected from lithium induced radiation damage (SF2 of 33%±8% for lithium treated cells vs. 27%±3% for untreated controls (p=0.05). Poor survival of patients with TP53 mutant medulloblastoma may be related to radiation resistance. Since constitutive activation of the WNT pathway by lithium sensitizes TP53 mutant medulloblastoma cells and protect normal neural stem cells from radiation, this oral drug may represent an attractive novel therapy for high-risk medulloblastomas.

Tuning the diurnal natural daylight with phosphor converted white LED – Advent of new phosphor blend composition

International Nuclear Information System (INIS)

Kim, Yoon Hwa; Arunkumar, Paulraj; Park, Seung Hyok; Yoon, Ho Shin; Im, Won Bin

2015-01-01

Highlights: • Designed phosphor blend that mimics diurnal daylight for health benefits. • Developed new phosphor blend composition that mimics natural sunlight under near UV. • The phosphor blend also exhibits high CRI (≥90) under blue LED excitation. • Fabricated WLED exhibited ∼91% spectral resemblance with daylight at 4500 K. • While ∼39.2% spectral resemblance were observed for YAG:Ce 3+ at 4500 K. - Abstract: We demonstrate the feasibility of developing phosphor converted white LED (pc-WLED) that mimics diurnal natural daylight with the newly designed phosphor blend in the color temperature (CCT) 2700–6000 K for health benefits. Natural daylight (sunlight) spectrum possesses broad emission in the visible region and closely approximates black body radiator, with color rendition index (CRI) of 100 under wide CCT (2500–6500 K). Current white light LEDs although are efficient and durable, they are not broad enough compared to daylight. We report new phosphor blend based on Sr 3 MgSi 2 O 8 :Eu 2+ blue phosphor with broad emission and high CRI ≥ 96 under both near UV and blue excitation. The fabricated WLED has exhibited ∼91% spectral resemblance with natural daylight compared to 39.2% for YAG:Ce 3+ white LED at 4500 K. The developed phosphor blend tunes the spectrum in wider CCT and would be a prospective candidate for full spectrum daylight WLED

Application of strong phosphoric acid to radiochemistry

International Nuclear Information System (INIS)

Terada, Kikuo

1977-01-01

Not only inorganic and organic compounds but also natural substrances, such as accumulations in soil, are completely decomposed and distilled by heating with strong phosphoric acid for 30 to 50 minutes. As applications of strong phosphoric acid to radiochemistry, determination of uranium and boron by use of solubilization effect of this substance, titration of uranyl ion by use of sulfuric iron (II) contained in this substance, application to tracer experiment, and determination of radioactive ruthenium in environmental samples are reviewed. Strong phosphoric acid is also applied to activation analysis, for example, determination of N in pyrographite with iodate potassium-strong phosphoric acid method, separation of Os and Ru with sulfuric cerium (IV) - strong phosphoric acid method or potassium dechromate-strong phosphoric acid method, analysis of Se, As and Sb rocks and accumulations with ammonium bromide, sodium chloride and sodium bromide-strong phosphoric acid method. (Kanao, N.)

21 CFR 182.1073 - Phosphoric acid.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Phosphoric acid. 182.1073 Section 182.1073 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN....1073 Phosphoric acid. (a) Product. Phosphoric acid. (b) Conditions of use. This substance is generally...

21 CFR 582.1073 - Phosphoric acid.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Phosphoric acid. 582.1073 Section 582.1073 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL... Additives § 582.1073 Phosphoric acid. (a) Product. Phosphoric acid. (b) Conditions of use. This substance is...

TP53 mutation spectrum in smokers and never smoking lung cancer patients

Directory of Open Access Journals (Sweden)

Ann Rita Halvorsen

2016-05-01

Full Text Available AbstractBackground: TP53 mutations are among the most common mutations found in lung cancers, identified as an independent prognostic factor in many types of cancers. The purpose of this study was to investigate the frequency and prognostic impact of TP53 mutations in never-smokers and in different histological subtypes of lung cancer.Methods: We analysed tumour tissue from 394 non-small cell carcinomas including adenocarcinomas (n=229, squamous cell carcinomas (n=112, large cell carcinomas (n=30 and others (n=23 for mutations in TP53 by the use of Sanger sequencing (n=394 and next generation sequencing (n=100. Results: TP53 mutations were identified in 47.2% of the samples, with the highest frequency (65% of mutations among squamous cell carcinomas. Among never-smokers, 36% carried a TP53 mutation, identified as a significant independent negative prognostic factor in this subgroup. For large cell carcinomas, a significantly prolonged progression free survival was found for those carrying a TP53 mutation. In addition, the frequency of frameshift mutations was doubled in squamous cell carcinomas (20.3% compared to adenocarcinomas (9.1%.Conclusion: TP53 mutation patterns differ between the histological subgroups of lung cancers, as also influenced by smoking history. This indicates that the histological subtypes in lung cancer are genetically different, and that smoking-induced TP53 mutations may have a different biological impact than TP53 mutations occurring in never-smokers.

Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran.

Directory of Open Access Journals (Sweden)

Behnoush Abedi-Ardekani

Full Text Available BACKGROUND: Golestan Province in northeastern Iran has one of the highest incidences of esophageal squamous cell carcinoma (ESCC in the world with rates over 50 per 100,000 person-years in both sexes. We have analyzed TP53 mutation patterns in tumors from this high-risk geographic area in search of clues to the mutagenic processes involved in causing ESCC. METHODOLOGY/PRINCIPAL FINDINGS: Biopsies of 119 confirmed ESCC tumor tissue from subjects enrolled in a case-control study conducted in Golestan Province were analyzed by direct sequencing of TP53 exons 2 through 11. Immunohistochemical staining for p53 was carried out using two monoclonal antibodies, DO7 and 1801. A total of 120 TP53 mutations were detected in 107/119 cases (89.9%, including 11 patients with double or triple mutations. The mutation pattern was heterogeneous with infrequent mutations at common TP53 "hotspots" but frequent transversions potentially attributable to environmental carcinogens forming bulky DNA adducts, including 40% at bases known as site of mutagenesis by polycyclic aromatic hydrocarbons (PAHs. Mutations showed different patterns according to the reported temperature of tea consumption, but no variation was observed in relation to ethnicity, tobacco or opium use, and alcoholic beverage consumption or urban versus rural residence. CONCLUSION/SIGNIFICANCE: ESCC tumors in people from Golestan Province show the highest rate of TP53 mutations ever reported in any cancer anywhere. The heterogeneous mutation pattern is highly suggestive of a causative role for multiple environmental carcinogens, including PAHs. The temperature and composition of tea may also influence mutagenesis.

Tuning the diurnal natural daylight with phosphor converted white LED – Advent of new phosphor blend composition

Energy Technology Data Exchange (ETDEWEB)

Kim, Yoon Hwa [School of Materials Science and Engineering, Chonnam National University, 300, Yongbong-dong, Buk-gu, Gwangju 500-757 (Korea, Republic of); Research Institute, Force4 Corp., Daechon-dong, Buk-gu, Gwangju 500-470 (Korea, Republic of); Arunkumar, Paulraj [School of Materials Science and Engineering, Chonnam National University, 300, Yongbong-dong, Buk-gu, Gwangju 500-757 (Korea, Republic of); Park, Seung Hyok; Yoon, Ho Shin [Research Institute, Force4 Corp., Daechon-dong, Buk-gu, Gwangju 500-470 (Korea, Republic of); Im, Won Bin, E-mail: imwonbin@jnu.ac.kr [School of Materials Science and Engineering, Chonnam National University, 300, Yongbong-dong, Buk-gu, Gwangju 500-757 (Korea, Republic of)

2015-03-15

Highlights: • Designed phosphor blend that mimics diurnal daylight for health benefits. • Developed new phosphor blend composition that mimics natural sunlight under near UV. • The phosphor blend also exhibits high CRI (≥90) under blue LED excitation. • Fabricated WLED exhibited ∼91% spectral resemblance with daylight at 4500 K. • While ∼39.2% spectral resemblance were observed for YAG:Ce{sup 3+} at 4500 K. - Abstract: We demonstrate the feasibility of developing phosphor converted white LED (pc-WLED) that mimics diurnal natural daylight with the newly designed phosphor blend in the color temperature (CCT) 2700–6000 K for health benefits. Natural daylight (sunlight) spectrum possesses broad emission in the visible region and closely approximates black body radiator, with color rendition index (CRI) of 100 under wide CCT (2500–6500 K). Current white light LEDs although are efficient and durable, they are not broad enough compared to daylight. We report new phosphor blend based on Sr{sub 3}MgSi{sub 2}O{sub 8}:Eu{sup 2+} blue phosphor with broad emission and high CRI ≥ 96 under both near UV and blue excitation. The fabricated WLED has exhibited ∼91% spectral resemblance with natural daylight compared to 39.2% for YAG:Ce{sup 3+} white LED at 4500 K. The developed phosphor blend tunes the spectrum in wider CCT and would be a prospective candidate for full spectrum daylight WLED.

Color stable manganese-doped phosphors

Science.gov (United States)

Lyons, Robert Joseph [Burnt Hills, NY; Setlur, Anant Achyut [Niskayuna, NY; Deshpande, Anirudha Rajendra [Twinsburg, OH; Grigorov, Ljudmil Slavchev [Sofia, BG

2012-08-28

A process for preparing color stable Mn.sup.+4 doped phosphors includes providing a phosphor of formula I; A.sub.x[MF.sub.y]:Mn.sup.+4 I and contacting the phosphor in particulate form with a saturated solution of a composition of formula II in aqueous hydrofluoric acid; A.sub.x[MF.sub.y]; II wherein A is Li, Na, K, Rb, Cs, NR.sub.4 or a combination thereof; M is Si, Ge, Sn, Ti, Zr, Al, Ga, In, Sc, Y, La, Nb, Ta, Bi, Gd, or a combination thereof; R is H, lower alkyl, or a combination thereof; x is the absolute value of the charge of the [MF.sub.y] ion; and y is 5, 6 or 7. In particular embodiments, M is Si, Ge, Sn, Ti, Zr, or a combination thereof. A lighting apparatus capable of emitting white light includes a semiconductor light source; and a phosphor composition radiationally coupled to the light source, and which includes a color stable Mn.sup.+4 doped phosphor.

Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum

International Nuclear Information System (INIS)

Brautigam, Chad A.; Deka, Ranjit K.; Norgard, Michael V.

2013-01-01

The soluble portion of TP0435, a putative periplasmic lipoprotein from the syphilis spirochete T. pallidum, has been purified and crystallized in a rhombohedral space group. A complete native data set has been collected to 2.4 Å resolution. Syphilis, caused by the bacterial spirochete Treponema pallidum, remains a prominent sexually transmitted infection worldwide. Despite sequencing of the genome of this obligate human pathogen 15 years ago, the functions of a large number of the gene products of T. pallidum are still unknown, particularly with respect to those of the organism’s periplasmic lipoproteins. To better understand their functions, a structural biology approach has been pursued. To this end, the soluble portion of the T. pallidum TP0435 lipoprotein (also known as Tp17) was cloned, hyper-expressed in Escherichia coli and purified to apparent homogeneity. The protein crystals obtained from this preparation diffracted to 2.4 Å resolution and had the symmetry of space group R3. In the hexagonal setting, the unit-cell parameters were a = b = 85.7, c = 85.4 Å

Improvements in x-ray image converters and phosphors

International Nuclear Information System (INIS)

Rabatin, J.G.

1981-01-01

Improvements to an X-ray image converter comprising crystals of rare earth phosphor admixtures are described. The phosphor admixtures utilize thulium-activated lanthanum and/or gadolinium oxyhalide phosphor material to increase the relative speed and resolution of an X-ray image compared with conventional rare earth phosphors. Examples of various radiographic screens containing one or more of the phosphor materials are given. (U.K.)

Fluorescent lighting with aluminum nitride phosphors

Science.gov (United States)

Cherepy, Nerine J.; Payne, Stephen A.; Seeley, Zachary M.; Srivastava, Alok M.

2016-05-10

A fluorescent lamp includes a glass envelope; at least two electrodes connected to the glass envelope; mercury vapor and an inert gas within the glass envelope; and a phosphor within the glass envelope, wherein the phosphor blend includes aluminum nitride. The phosphor may be a wurtzite (hexagonal) crystalline structure Al.sub.(1-x)M.sub.xN phosphor, where M may be drawn from beryllium, magnesium, calcium, strontium, barium, zinc, scandium, yttrium, lanthanum, cerium, praseodymium, europium, gadolinium, terbium, ytterbium, bismuth, manganese, silicon, germanium, tin, boron, or gallium is synthesized to include dopants to control its luminescence under ultraviolet excitation. The disclosed Al.sub.(1-x)M.sub.xN:Mn phosphor provides bright orange-red emission, comparable in efficiency and spectrum to that of the standard orange-red phosphor used in fluorescent lighting, Y.sub.2O.sub.3:Eu. Furthermore, it offers excellent lumen maintenance in a fluorescent lamp, and does not utilize "critical rare earths," minimizing sensitivity to fluctuating market prices for the rare earth elements.

Prediction of Microcystis Blooms Based on TN:TP Ratio and Lake Origin

Directory of Open Access Journals (Sweden)

Yoshimasa Amano

2008-01-01

Full Text Available We evaluated the relationship between TN:TP ratio and Microcystis growth via a database that includes worldwide lakes based on four types of lake origin (dammed, tectonic, coastal, and volcanic lakes. We used microcosm and mesocosm for the nutrient elution tests with lake water and four kinds of sediment (nontreated, MgO sprinkling treated, dissolved air flotation [DAF] treated, and combined treated sediment in order to control TN:TP ratio and to suppress Microcystis growth. Microcystis growth was related to TN:TP ratio, with the maximum value at an optimum TN:TP ratio and the minimum values when the TN:TP ratios reached to 0 or ∞. The kurtosis of the distribution curve varied with the type of lake origin; the lowest kurtosis was found in dammed lakes, while the highest was found in volcanic lakes. The lake trophic state could affect the change in the kurtosis, providing much lower kurtosis at eutrophic lakes (dammed lakes than that at oligotrophic lakes (volcanic lakes. The relationship between TN:TP ratio and Microcystis growth could be explained by the nutrient elution tests under controlled TN:TP ratios through the various sediment treatments. A significant suppression of Microcystis growth of 70% could be achieved when the TN:TP ratios exceeded 21. Lake origin could be regarded as an index including morphological and geographical factors, and controlling the trophic state in lakes. The origin rather than trophic state for lakes could be considered as an important factor of TN:TP influences on Microcystis growth.

TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.

Science.gov (United States)

Kucab, Jill E; Zwart, Edwin P; van Steeg, Harry; Luijten, Mirjam; Schmeiser, Heinz H; Phillips, David H; Arlt, Volker M

2016-03-01

3-Nitrobenzanthrone (3-NBA) is a highly mutagenic compound and possible human carcinogen found in diesel exhaust. 3-NBA forms bulky DNA adducts following metabolic activation and induces predominantly G:CT:A transversions in a variety of experimental systems. Here we investigated the influence of nucleotide excision repair (NER) on 3-NBA-induced mutagenesis of the human tumour suppressor gene TP53 and the reporter gene lacZ. To this end we utilised Xpa -knockout (Xpa-Null) human TP53 knock-in (Hupki) embryo fibroblasts (HUFs). As Xpa is essential for NER of bulky DNA adducts, we hypothesized that DNA adducts induced by 3-NBA would persist in the genomes of Xpa-Null cells and lead to an increased frequency of mutation. The HUF immortalisation assay was used to select for cells harbouring TP53 mutations following mutagen exposure. We found that Xpa-Null Hupki mice and HUFs were more sensitive to 3-NBA treatment than their wild-type (Xpa-WT) counterparts. However, following 3-NBA treatment and immortalisation, a similar frequency of TP53-mutant clones arose from Xpa-WT and Xpa-Null HUF cultures. In cells from both Xpa genotypes G:CT:A transversion was the predominant TP53 mutation type and mutations exhibited bias towards the non-transcribed strand. Thirty-two percent of 3-NBA-induced TP53 mutations occurred at CpG sites, all of which are hotspots for mutation in smokers' lung cancer (codons 157, 158, 175, 245, 248, 273, 282). We also examined 3-NBA-induced mutagenesis of an integrated lacZ reporter gene in HUFs, where we again observed a similar mutant frequency in Xpa-WT and Xpa-Null cells. Our findings suggest that 3-NBA-DNA adducts may evade removal by global genomic NER; the persistence of 3-NBA adducts in DNA may be an important factor in its mutagenicity. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

Uranium extraction from phosphoric acid

International Nuclear Information System (INIS)

Lounis, A.

1983-05-01

A study has been carried out for the extraction of uranium from phosphoric acid produced in Algeria. First of all, the Algerian phosphoric acid produced in Algeria by SONATRACH has been characterised. This study helped us to synthesize a phosphoric acid that enabled us to pass from laboratory tests to pilot scale tests. We have then examined extraction and stripping parameters: diluent, DZEPHA/TOPO ratio and oxidising agent. The laboratory experiments enabled us to set the optimum condition for the choice of diluent, extractant concentration, ratio of the synergic mixture, oxidant concentration, redox potential. The equilibrium isotherms lead to the determination of the number of theoretical stages for the uranium extraction and stripping of uranium, then the extraction from phosphoric acid has been verified on a pilot scale (using a mixer-settler)

Clear Plaque Mutants of Lactococcal Phage TP901-1

DEFF Research Database (Denmark)

Kot, Witold; Kilstrup, Mogens; Vogensen, Finn K.

2016-01-01

We report a method for obtaining turbid plaques of the lactococcal bacteriophage TP901-1 and its derivative TP901-BC1034. We have further used the method to isolate clear plaque mutants of this phage. Analysis of 8 such mutants that were unable to lysogenize the host included whole genome...

Phosphors for X-ray intensification screens

International Nuclear Information System (INIS)

Rebatin, J.G.

1980-01-01

An improved rare earth oxyhalide phosphor for x-ray intensification screens is described. The phosphors, of formula LnOX.T where Ln = La or Gd, X = Cl or Br and T = Tm or Tb, are mixed with a small amount of a trivalent antimony compound. The addition of antimony overcomes ageing due to attack by atmospheric moisture and renders the phosphor freeflowing so that dispersions can be readily made. Preferably the phosphor is washed with an aqueous solution of the antimony compound and the compound is the fluoride, chloride or butoxide, or potassium antimony tartrate. (U.K.)

[Evaluation of the Performance of Two Kinds of Anti-TP Enzyme-Linked Immunosorbent Assay].

Science.gov (United States)

Gao, Nan; Huang, Li-Qin; Wang, Rui; Jia, Jun-Jie; Wu, Shuo; Zhang, Jing; Ge, Hong-Wei

2018-06-01

To evaluate the accuracy and precision of 2 kinds of anti-treponema pallidum (anti-TP) ELISA reagents in our laboratory for detecting the anti-TP in voluntary blood donors, so as to provide the data support for use of ELISA reagents after introduction of chemiluminescene immunoassay (CLIA). The route detection of anti-TP was performed by using 2 kinds of ELISA reagents, then 546 responsive positive samples detected by anti-TP ELISA were collected, and the infections status of samples confirmed by treponema pallidum particle agglutination (TPPA) test was identified. The confirmed results of responsive samples detected by 2 kinds of anti-TP ELISA reagents were compared, the accuracy of 2 kinds of anti-TP ELISA reagents was analyzed by drawing ROC and comparing area under curve (AUC), and precision of 2 kinds of anti-TP ELISA reagents was compared by statistical analysis of quality control data from 7.1 2016 to 6.30 2017. There were no statistical difference in confirmed positive rate of responsive samples and weak positive samples between 2 kinds of anti-TP ELISA reagents. The responsive samples detected by 2 kinds of anti-TP ELISA reagents accounted for 85.53%(467/546) of all responsive samples, the positive rate confirmed by TPPA test was 82.87%. 44 responsive samples detected by anti-TP ELISA reagent A and 35 responsive samples detected by anti-TP ELISA reagent B were confirmed to be negative by TPPA test. Comparison of AUC showed that the accuracy of 2 kinds of anti-TP ELISA reagents was more high, the difference between 2 reagents was not statistically significant. The coefficient of variation (CV) of anti-TP ELISA reagent A and B was 14.98% and 18.04% respectively, which met the precision requirement of ELISA test. The accuracy and precision of 2 kinds of anti-TP ELISA reagents used in our laboratory are similar, and using any one of anti-TP ELISA reagents all can satisfy the requirements of blood screening.

Diagnostic value of recombinant Tp0821 protein in serodiagnosis for syphilis.

Science.gov (United States)

Xie, Y; Xu, M; Wang, C; Xiao, J; Xiao, Y; Jiang, C; You, X; Zhao, F; Zeng, T; Liu, S; Kuang, X; Wu, Y

2016-04-01

Syphilis is a multistage sexually transmitted disease that remains a serious public health concern worldwide. The coexistence of Treponema pallidum with other closely related members of spirochaeta, such as Leptospira spp. and Borrelia burgdorferi, has complicated the serodiagnosis due to cross-reactive antigens. In this study, recombinant Tp0821 protein was expressed in Escherichia coli and purified by metal affinity chromatography. Then enzyme-linked immunosorbent assays (ELISAs) based on Tp0821 for the detection of specific antibodies were established. The relative positive rates of the IgM ELISA and the IgG ELISA were found to be 91·0 and 98·3%, respectively, when screening 578 syphilis specimens. The specificities were 94·3 and 100%, respectively, when cross-checking with serum samples obtained from 30 patients with Lyme disease, five patients with leptospirosis, and 52 uninfected controls. In addition, relative positive rates and specificities of Tp0821 for human sera were all 100% in Western blotting. When compared to the syphilis diagnostic tests commonly used in clinical settings, we found that the results of Tp0821-based ELISAs correlated well with the results of the treponemal tests, specifically the T. pallidum particle agglutination (TP-PA) test and the chemiluminescent immunoassay (CIA). Thus, these findings identify Tp0821 as a novel serodiagnostic candidate for syphilis. In this study, we expressed and purified the Treponema pallidum protein Tp0821 and developed Tp0821-based enzyme-linked immunosorbent assays (ELISAs) for the detection of specific antibodies. The serodiagnostic performance of the recombinant protein was then evaluated. When compared to the results of syphilis diagnostic tests commonly used in clinical settings, we found that the reactivities of syphilitic sera with the recombinant antigen correlated well with the results of the treponemal tests, specifically the T. pallidum particle agglutination (TP-PA) test and the

Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis

Directory of Open Access Journals (Sweden)

Marilanda Ferreira Bellini

2012-01-01

Full Text Available TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis. Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH, overexpression of the p53 protein, and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response. Furthermore, Single Nucleotide Polymorphisms (SNPs of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development.

Method of preparing a thermoluminescent phosphor

Science.gov (United States)

Lasky, Jerome B.; Moran, Paul R.

1979-01-01

A thermoluminescent phosphor comprising LiF doped with boron and magnesium is produced by diffusion of boron into a conventional LiF phosphor doped with magnesium. Where the boron dopant is made to penetrate only the outer layer of the phosphor, it can be used to detect shallowly penetrating radiation such as tritium beta ays in the presence of a background of more penetrating radiation.

Whole blood coagulation time, haematocrit, haemoglobin and total ...

African Journals Online (AJOL)

The study was carried out to determine the values of whole blood coagulation time (WBCT), haematocrit (HM), haemaglobin (HB) and total protein (TP) of one hundred and eighteen apparently healthy turkeys reared under an extensive management system in Zaria. The mean values for WBCT, HM, HB and TP were 1.12 ...

Bioinformatics and phylogenetic analysis of human Tp73 gene ...

African Journals Online (AJOL)

The Tp73 gene encoding p73 protein belongs to the Tp53 gene family and it functions in the initiation of cell-cycle arrest or apoptosis and also involves in regulating a series of pathways including breast cancer, neuroblastoma and cholorectal cancer. New discoveries about the control and function of p73 are still in progress ...

The Influence of Phosphor and Binder Chemistry on the Aging Characteristics of Remote Phosphor Products

Energy Technology Data Exchange (ETDEWEB)

Davis, Lynn; Yaga, Robert; Lamvik, Michael; Mills, Karmann; Fletcher, B.

2017-06-30

The influence of phosphor and binder layer chemistries on the lumen maintenance and color stability of remote phosphor disks were examined using wet high-temperature operational lifetime testing (WHTOL). As part of the experimental matrix, two different correlated color temperature (CCT) values, 2700 K and 5000 K, were studied and each had a different binder chemistry. The 2700 K samples used a urethane binder whereas the 5000 K samples used an acrylate binder. Experimental conditions were chosen to enable study of the binder and phosphor chemistries and to minimize photo-oxidation of the polycarbonate substrate. Under the more severe WHTOL conditions of 85°C and 85% relative humidity (RH), absorption in the binder layer significantly reduced luminous flux and produced a blue color shift. The milder WHTOL conditions of 75°C and 75% RH, resulted in chemical changes in the binder layer that may alter its index of refraction. As a result, lumen maintenance remained high, but a slight yellow shift was found. The aging of remote phosphor products provides insights into the impact of materials on the performance of phosphors in an LED lighting system.

Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer

DEFF Research Database (Denmark)

Schildkraut, Joellen M; Goode, Ellen L; Clyde, Merlise A

2009-01-01

The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5,206 invasive ovarian cancer cases (2,829...

Protein - TP Atlas | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...p_atlas_protein.zip File URL: ftp://ftp.biosciencedbc.jp/archive/tp_atlas/LATEST/...story of This Database Site Policy | Contact Us Protein - TP Atlas | LSDB Archive ...

Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models

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Tao Lu

2017-01-01

Full Text Available Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson's disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic (DA neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibition of Tp53 function by pharmacological inhibitors and in traditional Tp53 knock-out mice, we examined the effects of DA-specific Tp53 gene deletion after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and methamphetamine exposure. Our data suggests that the Tp53 gene might be involved in both neuronal apoptosis and neuronal terminal damage caused by different neurotoxicants. Additional results from other studies also suggest that as a master regulator of many pathways that regulate apoptosis and synaptic terminal damage, it is possible that Tp53 may function as a signaling hub to integrate different signaling pathways to mediate distinctive target pathways. Tp53 protein as a signaling hub might be able to evaluate the microenvironment of neurons, assess the forms and severities of injury incurred, and determine whether apoptotic cell death or neuronal terminal degeneration occurs. Identification of the precise mechanisms activated in distinct neuronal damage caused by different forms and severities of injuries might allow for development of specific Tp53 inhibitors or ways to modulate distinct downstream target pathways involved.

Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

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Simona Ognjanovic

2012-01-01

Full Text Available The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. The reported prevalence of mutations in rhabdomyosarcoma (RMS varies widely, with recent larger studies suggesting that TP53 mutations in pediatric RMS may be extremely rare. Overexpression of MDM2 also attenuates p53 function. We have performed TP53 mutation/MDM2 amplification analyses in the largest series analyzed thus far, including DNA isolated from 37 alveolar and 38 embryonal RMS tumor samples obtained from the Cooperative Human Tissue Network (CHTN. Available samples were frozen tumor tissues (N=48 and histopathology slides. TP53 mutations in exons 4–9 were analyzed by direct sequencing in all samples, and MDM2 amplification analysis was performed by differential PCR on a subset of 22 samples. We found only one sample (1/75, 1.3% carrying a TP53 mutation at codon 259 (p.D259Y and no MDM2 amplification. Two SNPs in the TP53 pathway, associated with accelerated tumor onset in germline TP53 mutation carriers, (TP53 SNP72 (rs no. 1042522 and MDM2 SNP309 (rs no. 2279744, were not found to confer earlier tumor onset. In conclusion, we confirm the extremely low prevalence of TP53 mutations/MDM2 amplifications in pediatric RMS (1.33% and 0%, respectively. The possible inactivation of p53 function by other mechanisms thus remains to be elucidated.

Consumption of Pt anode in phosphoric acid

Energy Technology Data Exchange (ETDEWEB)

Kamiya, N.; Urata, K.; Motohira, N.; Ota, K. [Yokohama National University, Yokohama (Japan)

1997-12-05

Consumption of Pt anode was investigated in phosphoric acid of various concentration. In 30-70wt% phosphoric acid, Pt dissolved at the rate of 19{mu}gcm{sup -2}h{sup -1}. On the other hand, in 85 wt% phosphoric acid, the amount increased to 0.91 mgcm{sup -2}h{sup -1} which is ca. 180 and 1800 times as much as in 1M sulfuric acid and 1M alkaline solution, respectively. In the diluted phosphoric acid solution, the Pt surface was covered with Pt oxides during the electrolysis, which would prevent the surface from corrosion. However, in the concentrated phosphoric acid, no such oxide surface was observed. Concentrated phosphoric acid might form stable complex with Pt species, therefore the uncovered bare Pt surface is situated in the serious corrosion condition under the high overvoltage and Pt would dissolve into the solution directly instead of forming the Pt oxides. 11 refs., 9 figs., 1 tab.

Process for recovering a uranium containing concentrate and purified phosphoric acid from a wet process phosphoric acid containing uranium

International Nuclear Information System (INIS)

Weterings, C.A.M.; Janssen, J.A.

1985-01-01

A process is claimed for recovering from a wet process phosphoric acid which contains uranium, a uranium containing concentrate and a purified phosphoric acid. The wet process phosphoric acid is treated with a precipitant in the presence of a reducing agent and an aliphatic ketone

Process for recovering a uranium containing concentrate and purified phosphoric acid from a wet process phosphoric acid containing uranium

Energy Technology Data Exchange (ETDEWEB)

Weterings, C.A.M.; Janssen, J.A.

1985-04-30

A process is claimed for recovering from a wet process phosphoric acid which contains uranium, a uranium containing concentrate and a purified phosphoric acid. The wet process phosphoric acid is treated with a precipitant in the presence of a reducing agent and an aliphatic ketone.

Modelling of the estimated contributions of different sub-watersheds and sources to phosphorous export and loading from the Dongting Lake watershed, China.

Science.gov (United States)

Hou, Ying; Chen, Weiping; Liao, Yuehua; Luo, Yueping

2017-11-03

Considerable growth in the economy and population of the Dongting Lake watershed in Southern China has increased phosphorus loading to the lake and resulted in a growing risk of lake eutrophication. This study aimed to reveal the spatial pattern and sources of phosphorus export and loading from the watershed. We applied an export coefficient model and the Dillon-Rigler model to quantify contributions of different sub-watersheds and sources to the total phosphorus (TP) export and loading in 2010. Together, the upper and lower reaches of the Xiang River watershed and the Dongting Lake Area contributed 60.9% of the TP exported from the entire watershed. Livestock husbandry appeared to be the largest anthropogenic source of TP, contributing more than 50% of the TP exported from each secondary sub-watersheds. The actual TP loading to the lake in 2010 was 62.9% more than the permissible annual TP loading for compliance with the Class III water quality standard for lakes. Three primary sub-watersheds-the Dongting Lake Area, the Xiang River, and the Yuan River watersheds-contributed 91.2% of the total TP loading. As the largest contributor among all sources, livestock husbandry contributed nearly 50% of the TP loading from the Dongting Lake Area and more than 60% from each of the other primary sub-watersheds. This study provides a methodology to identify the key sources and locations of TP export and loading in large lake watersheds. The study can provide a reference for the decision-making for controlling P pollution in the Dongting Lake watershed.

Method of purifying phosphoric acid after solvent extraction

International Nuclear Information System (INIS)

Kouloheris, A.P.; Lefever, J.A.

1979-01-01

A method of purifying phosphoric acid after solvent extraction is described. The phosphoric acid is contacted with a sorbent which sorbs or takes up the residual amount of organic carrier and the phosphoric acid separated from the organic carrier-laden sorbent. The method is especially suitable for removing residual organic carrier from phosphoric acid after solvent extraction uranium recovery. (author)

TP53 dysfunction in CLL: Implications for prognosis and treatment

NARCIS (Netherlands)

te Raa, Gera D.; Kater, Arnon P.

2016-01-01

Despite the availability of novel targeted agents, TP53 defects remain the most important adverse prognostic factor in chronic lymphocytic leukemia (CLL). Detection of deletion of TP53 locus (17p deletion) by fluorescent in situ hybridization (FISH) has become standard and performed prior to every

Rare earth elements recycling from waste phosphor by dual hydrochloric acid dissolution

International Nuclear Information System (INIS)

Liu, Hu; Zhang, Shengen; Pan, Dean; Tian, Jianjun; Yang, Min; Wu, Maolin; Volinsky, Alex A.

2014-01-01

Highlights: • The article provides a new method for recycling rare earth (RE) from waste phosphor. • When compared with the traditional methods, leach rate was much higher. • Y–Eu concentrate and Tb–Ce concentrate were obtained successively. • It would reduce the burden of later extraction, separation and purification. - Abstract: This paper is a comparative study of recycling rare earth elements from waste phosphor, which focuses on the leaching rate and the technical principle. The traditional and dual dissolution by hydrochloric acid (DHA) methods were compared. The method of dual dissolution by hydrochloric acid has been developed. The Red rare earth phosphor (Y 0.95 Eu 0.05 ) 2 O 3 in waste phosphor is dissolved during the first step of acid leaching, while the Green phosphor (Ce 0.67 Tb 0.33 MgAl 11 O 19 ) and the Blue phosphor (Ba 0.9 Eu 0.1 MgAl 10 O 17 ) mixed with caustic soda are obtained by alkali sintering. The excess caustic soda and NaAlO 2 are removed by washing. The insoluble matter is leached by the hydrochloric acid, followed by solvent extraction and precipitation (the DHA method). In comparison, the total leaching rate of the rare earth elements was 94.6% by DHA, which is much higher than 42.08% achieved by the traditional method. The leaching rate of Y, Eu, Ce and Tb reached 94.6%, 99.05%, 71.45%, and 76.22%, respectively. DHA can decrease the consumption of chemicals and energy. The suggested DHA method is feasible for industrial applications

Limited importance of the dominant-negative effect of TP53 missense mutations

International Nuclear Information System (INIS)

Stoczynska-Fidelus, Ewelina; Liberski, Pawel P; Rieske, Piotr; Szybka, Malgorzata; Piaskowski, Sylwester; Bienkowski, Michal; Hulas-Bigoszewska, Krystyna; Banaszczyk, Mateusz; Zawlik, Izabela; Jesionek-Kupnicka, Dorota; Kordek, Radzislaw

2011-01-01

Heterozygosity of TP53 missense mutations is related to the phenomenon of the dominant-negative effect (DNE). To estimate the importance of the DNE of TP53 mutations, we analysed the percentage of cancer cases showing a single heterozygous mutation of TP53 and searched for a cell line with a single heterozygous mutation of this gene. This approach was based on the knowledge that genes with evident DNE, such as EGFR and IDH1, represent nearly 100% of single heterozygous mutations in tumour specimens and cell lines. Genetic analyses (LOH and sequencing) performed for early and late passages of several cell lines originally described as showing single heterozygous TP53 mutations (H-318, G-16, PF-382, MOLT-13, ST-486 and LS-123). Statistical analysis of IARC TP53 and SANGER databases. Genetic analyses of N-RAS, FBXW7, PTEN and STR markers to test cross-contamination and cell line identity. Cell cloning, fluorescence-activated cell sorting and SSCP performed for the PF-382 cell line. A database study revealed TP53 single heterozygous mutations in 35% of in vivo (surgical and biopsy) samples and only 10% of cultured cells (in vitro), although those numbers appeared to be overestimated. We deem that published in vivo TP53 mutation analyses are not as rigorous as studies in vitro, and we did not find any cell line showing a stable, single heterozygous mutation. G16, PF-382 and MOLT-13 cells harboured single heterozygous mutations temporarily. ST-486, H-318 and LS-123 cell lines were misclassified. Specific mutations, such as R175H, R273H, R273L or R273P, which are reported in the literature to exert a DNE, showed the lowest percentage of single heterozygous mutations in vitro (about 5%). We suggest that the currently reported percentage of TP53 single heterozygous mutations in tumour samples and cancer cell lines is overestimated. Thus, the magnitude of the DNE of TP53 mutations is questionable. This scepticism is supported by database investigations showing that retention

Total nitrogen and total phosphorus removal from brackish aquaculture wastewater using effective microorganism

Science.gov (United States)

Mohamad, K. A.; Mohd, S. Y.; Sarah, R. S.; Mohd, H. Z.; Rasyidah, A.

2017-09-01

Aquaculture is one of dominant food based industry in the world with 8.3% annual growth rate and its development had led to adverse effect on the environment. High nutrient production in form of nitrogenous compound and phosphorus contributed to environmental deterioration such as eutrophication and toxicity to the industry. Usage of Effective Microorganism (EM), one of the biological approaches to remove Total Nitrogen (TN) and Total Phosphorus (TP) in aquaculture pond was proposed. Samples were obtained from the Sea Bass intensive brackish aquaculture wastewater (AW) from fish farm at Juru, Penang and the parameters used to measure the removal of nitrogenous compounds include, pH, EM dosage, shaking, contact time and optimum variable conditions. From the study, for effective contact time, day 6 is the optimum contact time for both TN and TP with 99.74% and 62.78% removal respectively while in terms of optimum pH, the highest TN removal was at pH 7 with 66.89 %. The optimum dosage of EM is 1.5 ml with ratio 1:166 for 81.5 % TN removal was also found appropriate during the experiment. At varied optimum conditions of EM, the removal efficiency of TN and TP were 81.53% and 38.94% respectively while the removal mechanism of TN was highly dependent on the decomposition rate of specific bacteria such as Nitrobacter bacteria, Yeast and Bacillus Subtilis sp. The study has established the efficacy of EM's ability to treat excessive nutrient of TN and TP from AW.

Pediatric oncologist willingness to offer germline TP53 testing in osteosarcoma.

Science.gov (United States)

Shaul, Eliana; Roth, Michael; Lo, Yungtai; Geller, David S; Hoang, Bang; Yang, Rui; Malkin, David; Gorlick, Richard; Gill, Jonathan

2018-03-15

Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by mutations in the tumor-suppressor gene TP53. Osteosarcoma is a sentinel cancer in LFS. Prior studies using Sanger sequencing platforms have demonstrated that 3% of individuals with osteosarcoma harbor a mutation in TP53. New data from next-generation sequencing have demonstrated that 3.8% of patients with osteosarcoma have a known pathogenic variant, and an additional 5.7% carry exonic variants of unknown significance in TP53. Pediatric oncologists were e-mailed an anonymous 18-question survey assessing their willingness to offer TP53 germline testing to a child with osteosarcoma with or without a family history, and they were evaluated for changes in their choices with the prior data and the new data. One hundred seventy-seven pediatric oncologists (22%) responded to the survey. Respondents were more likely to offer TP53 testing to a patient with a positive family history (77.4% vs 12.4%; P offer TP53 testing once they were provided with the new data (25.4% vs 12.4%; P = .0038). The proportion of providers who responded that they were unsure increased significantly when they were presented with the new data (25.4% vs 10.2%; P = .0002). Potential implications for other family members and the possibility that surveillance imaging would detect new malignancies at an earlier stage were important factors influencing a provider's decision to offer TP53 testing. Recent data increase the proportion of providers willing to offer testing, and this suggests concern on the part of pediatric oncologists that variants of unknown significance may be disease-defining in rare cancers. Cancer 2018;124:1242-50. © 2018 American Cancer Society. © 2018 American Cancer Society.

White light-emitting diodes (LEDs) using (oxy)nitride phosphors

International Nuclear Information System (INIS)

Xie, R-J; Hirosaki, N; Sakuma, K; Kimura, N

2008-01-01

(Oxy)nitride phosphors have attracted great attention recently because they are promising luminescent materials for phosphor-converted white light-emitting diodes (LEDs). This paper reports the luminescent properties of (oxy)nitride phosphors in the system of M-Si-Al-O-N (M = Li, Ca or Sr), and optical properties of white LEDs using a GaN-based blue LED and (oxy)nitride phosphors. The phosphors show high conversion efficiency of blue light, suitable emission colours and small thermal quenching. The bichromatic white LEDs exhibit high luminous efficacy (∼55 lm W -1 ) and the multi-phosphor converted white LEDs show high colour rendering index (Ra 82-95). The results indicate that (oxy)nitride phosphors demonstrate their superior suitability to use as down-conversion luminescent materials in white LEDs

TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells

Directory of Open Access Journals (Sweden)

Nikolett Sándor

2015-10-01

Full Text Available Tumor protein 53-induced nuclear protein-1 (TP53inp1 is expressed by activation via p53 and p73. The purpose of our study was to investigate the role of TP53inp1 in response of fibroblasts to ionizing radiation. γ-Ray radiation dose-dependently induces the expression of TP53inp1 in human immortalized fibroblast (F11hT cells. Stable silencing of TP53inp1 was done via lentiviral transfection of shRNA in F11hT cells. After irradiation the clonogenic survival of TP53inp1 knockdown (F11hT-shTP cells was compared to cells transfected with non-targeting (NT shRNA. Radiation-induced senescence was measured by SA-β-Gal staining and autophagy was detected by Acridine Orange dye and microtubule-associated protein-1 light chain 3 (LC3B immunostaining. The expression of TP53inp1, GDF-15, and CDKN1A and alterations in radiation induced mitochondrial DNA deletions were evaluated by qPCR. TP53inp1 was required for radiation (IR induced maximal elevation of CDKN1A and GDF-15 expressions. Mitochondrial DNA deletions were increased and autophagy was deregulated following irradiation in the absence of TP53inp1. Finally, we showed that silencing of TP53inp1 enhances the radiation sensitivity of fibroblast cells. These data suggest functional roles for TP53inp1 in radiation-induced autophagy and survival. Taken together, we suppose that silencing of TP53inp1 leads radiation induced autophagy impairment and induces accumulation of damaged mitochondria in primary human fibroblasts.

[Change traits of phosphorous consumption structure in China and their effects on environmental phosphorous loads].

Science.gov (United States)

Ma, Dun-Chao; Hu, Shan-Ying; Chen, Ding-Jiang; Li, You-Run

2012-04-01

Substance flow analysis was used to construct a model to analyze change traits of China's phosphorous (P) consumption structure from 1980 to 2008 and their influences on environmental phosphorous loads, then the correlation between several socioeconomic factors and phosphorous consumption pollution was investigated. It is found that phosphorous nutrient inputs of urban life and rural life on a per capita level climbed to 1.20 kg x a(-1) and 0.99 kg x a(-1) from 0.83 kg x a(-1) and 0.75 kg x a(-1) respectively, but phosphorous recycling ratios of urban life fell to 15.6% from 62.6%. P inputs of animal husbandry and planting also kept increasing, but the recycling ratio of the former decreased from 67.5% to 40.5%, meanwhile much P input of the latter was left in agricultural soil. Correlation coefficients were all above 0.90, indicating that population, urbanization level, development levels of planting and animal husbandry were important incentives for P consumption pollution in China. Environmental Kuznets curve showed that China still stayed in the early development stage, promoting economic growth at an expense of environmental quality. This study demonstrates that China's P consumption system is being transformed into a linear and open structure, and that P nutrient loss and environmental P loads increase continually.

Analisis Jaringan VPN Menggunakan PPTP dan L2TP

Directory of Open Access Journals (Sweden)

Syariful Ikhwan

2017-08-01

Full Text Available VPN adalah teknologi yang membuat jaringan private (pribadi dengan menggunakan jaringan publik agar proses pertukaran data menjadi aman. Teknologi VPN biasanya diterapkan untuk koneksi antara kantor pusat dan kantor cabang. Dinhubkominfo Kabupaten Banyumas sebagai tempat penelitian memiliki beberapa kantor cabang (SKPD. Data yang dipertukarkan antar kantor cabang pada Dinhubkominfo terdiri dari beberapa jenis, namun pada penelitian ini hanya difokuskan pada pertukaran layanan FTP. Teknologi vpn yang saat ini digunakan pada jaringan Dinhubkominfo adalah PPTP. Akan tetapi, penggunaan teknologi tersebut belum tersebut masih belum diketahui tingkat performansi jaringan dibandingkan dengan penggunaan teknologi vpn yang lain. Pada penelitian ini akan dibandingkan penggunaan dua teknologi vpn yang berbeda yaitu antara PPTP dan L2TP, dimana parameter yang digunakan adalah throughput, delay, jitter, dan packet loss. Proses pengambilan data dilakukan dengan menambahkan beban trafik sebesar 512 kbps, 1024 kbps, dan 2048 kbps. Dari hasil penelitian diperoleh data bahwa, rata-rata nilai Delay pada L2TP lebih besar hingga 41% dibanding saat menggunakan PPTP, rata-rata Throughput PPTP naik hingga 34% dibandingkan L2TP, Rata-rata Jitter pada PPTP lebih besar hingga 44% dibandingkan L2TP, sedangkan packet loss yang terjadi pada masing-masing layanan vpn adalah 0

Re-processing CRT phosphors for mercury-free applications

International Nuclear Information System (INIS)

Dexpert-Ghys, Jeannette; Regnier, Sophie; Canac, Sophie; Beaudette, Tristan; Guillot, Philippe; Caillier, Bruno; Mauricot, Robert; Navarro, Julien; Sekhri, Salem

2009-01-01

This study is part of an operation in the framework of treatment and revalorization of IEEE (Informatics, Electronics and related) wastes. It aims to recover the active phosphors in cathode ray tubes (CRTs) and to re-cycle these powders by appropriate treatments as phosphors for mercury-free applications such as plasma display panels, flat lamps, advertising and lighting. The studied waste comes from a large panel of CRTs from any supplier. Several thermo-chemical treatments have been investigated. The removal of zinc sulfide-based phosphors and the recovery of a red phosphor Y 2 O 3 :Eu 3+ has been achieved by one (basic attack) route. The photoluminescence efficiency under VUV excitation of the obtained powders is at most 30% that of a commercial phosphor. The second route (acid attack) appears less promising. It has been established that silicate-based impurities could prevent isolating the yttrium based phosphor.

Re-processing CRT phosphors for mercury-free applications

Energy Technology Data Exchange (ETDEWEB)

Dexpert-Ghys, Jeannette, E-mail: jdexpert@cemes.f [CEMES, 29 rue Jeanne Marvig, BP 94347, 31055 Toulouse cedex 4 (France); Regnier, Sophie; Canac, Sophie [ICAM, 75 avenue de Grande Bretagne, 31300 Toulouse (France); Beaudette, Tristan; Guillot, Philippe; Caillier, Bruno [DPHE, Universite Jean Francois Champollion, place de Verdun, 81012 Albi cedex 9 (France); Mauricot, Robert; Navarro, Julien [CEMES, 29 rue Jeanne Marvig, BP 94347, 31055 Toulouse cedex 4 (France); Sekhri, Salem [ENVOI, Cheminement Glueck, 31100 Toulouse (France)

2009-12-15

This study is part of an operation in the framework of treatment and revalorization of IEEE (Informatics, Electronics and related) wastes. It aims to recover the active phosphors in cathode ray tubes (CRTs) and to re-cycle these powders by appropriate treatments as phosphors for mercury-free applications such as plasma display panels, flat lamps, advertising and lighting. The studied waste comes from a large panel of CRTs from any supplier. Several thermo-chemical treatments have been investigated. The removal of zinc sulfide-based phosphors and the recovery of a red phosphor Y{sub 2}O{sub 3}:Eu{sup 3+} has been achieved by one (basic attack) route. The photoluminescence efficiency under VUV excitation of the obtained powders is at most 30% that of a commercial phosphor. The second route (acid attack) appears less promising. It has been established that silicate-based impurities could prevent isolating the yttrium based phosphor.

Modeling granular phosphor screens by Monte Carlo methods

International Nuclear Information System (INIS)

Liaparinos, Panagiotis F.; Kandarakis, Ioannis S.; Cavouras, Dionisis A.; Delis, Harry B.; Panayiotakis, George S.

2006-01-01

The intrinsic phosphor properties are of significant importance for the performance of phosphor screens used in medical imaging systems. In previous analytical-theoretical and Monte Carlo studies on granular phosphor materials, values of optical properties, and light interaction cross sections were found by fitting to experimental data. These values were then employed for the assessment of phosphor screen imaging performance. However, it was found that, depending on the experimental technique and fitting methodology, the optical parameters of a specific phosphor material varied within a wide range of values, i.e., variations of light scattering with respect to light absorption coefficients were often observed for the same phosphor material. In this study, x-ray and light transport within granular phosphor materials was studied by developing a computational model using Monte Carlo methods. The model was based on the intrinsic physical characteristics of the phosphor. Input values required to feed the model can be easily obtained from tabulated data. The complex refractive index was introduced and microscopic probabilities for light interactions were produced, using Mie scattering theory. Model validation was carried out by comparing model results on x-ray and light parameters (x-ray absorption, statistical fluctuations in the x-ray to light conversion process, number of emitted light photons, output light spatial distribution) with previous published experimental data on Gd 2 O 2 S:Tb phosphor material (Kodak Min-R screen). Results showed the dependence of the modulation transfer function (MTF) on phosphor grain size and material packing density. It was predicted that granular Gd 2 O 2 S:Tb screens of high packing density and small grain size may exhibit considerably better resolution and light emission properties than the conventional Gd 2 O 2 S:Tb screens, under similar conditions (x-ray incident energy, screen thickness)

Uranium recovery from wet-process phosphoric acid

International Nuclear Information System (INIS)

McCullough, J.F.; Phillips, J.F. Jr.; Tate, L.R.

1979-01-01

A method of recovering uranium from wet-process phosphoric acid is claimed where the acid is treated with a mixture of an ammonium salt or ammonia, a reducing agent, and then a miscible solvent. Solids are separated from the phosphoric acid liquid phase. The solid consists of a mixture of metal phosphates and uranium. It is washed free of adhering phosphoric acid with fresh miscible solvent. The solid is dried and dissolved in acid whereupon uranium is recovered from the solution. Miscible solvent and water are distilled away from the phosphoric acid. The distillate is rectified and water discarded. All miscible solvent is recovered for recycle. 5 claims

Rare earth elements recycling from waste phosphor by dual hydrochloric acid dissolution

Energy Technology Data Exchange (ETDEWEB)

Liu, Hu [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Zhang, Shengen, E-mail: zhangshengen@mater.ustb.edu.cn [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Pan, Dean; Tian, Jianjun; Yang, Min; Wu, Maolin [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Volinsky, Alex A. [Department of Mechanical Engineering, University of South Florida, Tampa, FL 33620 (United States)

2014-05-01

Highlights: • The article provides a new method for recycling rare earth (RE) from waste phosphor. • When compared with the traditional methods, leach rate was much higher. • Y–Eu concentrate and Tb–Ce concentrate were obtained successively. • It would reduce the burden of later extraction, separation and purification. - Abstract: This paper is a comparative study of recycling rare earth elements from waste phosphor, which focuses on the leaching rate and the technical principle. The traditional and dual dissolution by hydrochloric acid (DHA) methods were compared. The method of dual dissolution by hydrochloric acid has been developed. The Red rare earth phosphor (Y{sub 0.95}Eu{sub 0.05}){sub 2}O{sub 3} in waste phosphor is dissolved during the first step of acid leaching, while the Green phosphor (Ce{sub 0.67}Tb{sub 0.33}MgAl{sub 11}O{sub 19}) and the Blue phosphor (Ba{sub 0.9}Eu{sub 0.1}MgAl{sub 10}O{sub 17}) mixed with caustic soda are obtained by alkali sintering. The excess caustic soda and NaAlO{sub 2} are removed by washing. The insoluble matter is leached by the hydrochloric acid, followed by solvent extraction and precipitation (the DHA method). In comparison, the total leaching rate of the rare earth elements was 94.6% by DHA, which is much higher than 42.08% achieved by the traditional method. The leaching rate of Y, Eu, Ce and Tb reached 94.6%, 99.05%, 71.45%, and 76.22%, respectively. DHA can decrease the consumption of chemicals and energy. The suggested DHA method is feasible for industrial applications.

Phosphorous-Containing Polymers for Regenerative Medicine

Science.gov (United States)

Watson, Brendan M.; Kasper, F. Kurtis; Mikos, Antonios G.

2014-01-01

Disease and injury have resulted in a large, unmet need for functional tissue replacements. Polymeric scaffolds can be used to deliver cells and bioactive signals to address this need for regenerating damaged tissue. Phosphorous-containing polymers have been implemented to improve and accelerate the formation of native tissue both by mimicking the native role of phosphorous groups in the body and by attachment of other bioactive molecules. This manuscript reviews the synthesis, properties, and performance of phosphorous-containing polymers that can be useful in regenerative medicine applications. PMID:24565855

Preparation of high purification and food grade phosphoric acid from technical grade phosphoric acid by liquid-liquid detraction method

International Nuclear Information System (INIS)

Alimoradi, M.; Borji, F.; Kishani, A.

2002-01-01

Pay attention to increasing consumption of high purification and food grade phosphoric acid in various industries and food industries and on in on hand and lack of preparation between production and distribution of this products its purification is so vital. In this article of liquid-liquid extraction method with normal hexane-mixture of ammonia and acetone-diisopropyl alcohol and normal butanol solvents and these determination of distribution coefficient each one with ph-me try titration we can evaluate effectiveness and sufficiency each one. Because of proper coefficient distribution and its local production of normal butanol solvent and low price is the best solvent. To phosphoric acid modifying coefficient distribution for extraction of phosphoric acid we can add a little value sulfuric acid to the mixture and to remove flouride impurity we add a little Na 2 O. After extraction stage extracted phosphoric acid in the normal strips by evaluating with distilled water and then by passing the carbon active bed and following passes of cationic resine column and concentrated with vacuum distillation. Conclusion of this article is produce of phosphoric acid 85% w/w and food grade from impure phosphoric acid 52% w/w with technical grade

TP508 accelerates fracture repair by promoting cell growth over cell death

International Nuclear Information System (INIS)

Li Xinmin; Wang Hali; Touma, Edward; Qi Yuchen; Rousseau, Emma; Quigg, Richard J.; Ryaby, James T.

2007-01-01

TP508 is a synthetic 23-amino acid peptide representing a receptor-binding domain of human thrombin. We have previously shown that a single injection of TP508 accelerates fracture healing in a rat femoral fracture model. To understand how TP508 acts at the protein level during fracture healing, we compared the translational profiles between saline-control and fractured femur at six time points after TP508 treatment using the second generation of BD Clontech TM Antibody Microarray. Here, we demonstrate that TP508 accelerates fracture healing by modulating expression levels of proteins primarily involved in the functional categories of cell cycle, cellular growth and proliferation, and cell death. The majority of those proteins are physically interrelated and functionally overlapped. The action of those proteins is highlighted by a central theme of promoting cell growth via balance of cell survival over cell death signals. This appears to occur through the stimulation of several bone healing pathways including cell cycle-G1/S checkpoint regulation, apoptosis, JAK/STAT, NF-κB, PDGF, PI3K/AKT, PTEN, and ERK/MAPK

Pretreatment of industrial phosphoric acid by Algerian filter-aids

International Nuclear Information System (INIS)

Mellah, A.; Setti, Louisa; Chegrouche, Salah

1993-01-01

The present work involves the filtration of industrial phosphoric acid by different filter-aids such as kieselguhr, celite and bleaching clay. The retention of substances contained in wet phosphoric acid was determined using the three filter-aids. Thus, the phosphoric acid, obtained by filtration on kieselguhr has the same specifications as technical phosphoric acid produced by Rhone-Poulenc (France) as standard

Uranium extraction from phosphoric acid

International Nuclear Information System (INIS)

Araujo Figueiredo, C. de

1984-01-01

The recovery of uranium from phosphoric liquor by two extraction process is studied. First, uranium is reduced to tetravalent condition and is extracted by dioctypyrophosphoric acid. The re-extraction is made by concentrated phosphoric acid with an oxidizing agent. The re-extract is submitted to the second process and uranium is extracted by di-ethylhexilphosphoric acid and trioctylphosphine oxide. (M.A.C.) [pt

Phosphate Phosphors for Solid-State Lighting

CERN Document Server

Shinde, Kartik N; Swart, H C; Park, Kyeongsoon

2012-01-01

The idea for this book arose out of the realization that, although excellent surveys and a phosphor handbook are available, there is no single source covering the area of phosphate based phosphors especially for lamp industry. Moreover, as this field gets only limited attention in most general books on luminescence, there is a clear need for a book in which attention is specifically directed toward this rapidly growing field of solid state lighting and its many applications. This book is aimed at providing a sound introduction to the synthesis and optical characterization of phosphate phosphor for undergraduate and graduate students as well as teachers and researchers. The book provides guidance through the multidisciplinary field of solid state lighting specially phosphate phosphors for beginners, scientists and engineers from universities, research organizations, and especially industry. In order to make it useful for a wide audience, both fundamentals and applications are discussed, together.

X-ray investigation of phosphors for black-white television

International Nuclear Information System (INIS)

Lazowy, B.

1975-01-01

The investigations of phosphors made by means of the powder diffraction method are presented. The diffraction patterns has been obtained by means of the DRON-1 diffractometer, using the Ksub(α) copper radiation and a nickel filter. Reflex intensity was estimated, indexing was made and lattice constants for particular structure types were calculated. The objects of the investigations were the phosphors from various firms of white luminescence and home phosphors of white, blue and yellow luminescence. On the base of the results it was found that all investigated phosphors of yellow luminescence belonged to the hexagonal system. These phosphors, depending on baking conditions, have structure of regular symmetry. The phosphors of white luminescence are a mixture of hexagonal and regular phase and any changes in elementary cell sizes were not observed. All phosphors of white luminescence have analogous structure, positions of all reflexes are identical, negligible differences in their intensities occur only, which proves somewhat different arrangement of atoms in mixed crystals. (author)

Pretreatment of phosphoric acid for uranium recovery by the wet phosphoric acid process

International Nuclear Information System (INIS)

Chern, S.L.P.; Chen, Y.C.L.; Chang, S.S.H.; Kuo, T.S.; Ting, G.C.M.

1980-01-01

The proposal deals with reprocessing of phosphoric acid arising from uranium separation according to the wet phosphoric acid process and being intended for recycling. In detail, the sludge will be removed by means of an inclined separating device containing corrugated plates, then the organic impurities are washed out with kerosene in suitable facilities, and the crude phase remaining in the settling tank will be separated from the kerosene in a separating centrifuge. The method has only got low cost of installation. (UWI) [de

Compact fluorescent lamp phosphors in accidental radiation monitoring

International Nuclear Information System (INIS)

Murthy, K. V. R.; Pallavi, S. P.; Ghildiyal, R.; Parmar, M. C.; Patel, Y. S.; Ravi Kumar, V.; Sai Prasad, A. S.; Natarajan, V.; Page, A. G.

2006-01-01

The application of lamp phosphors for accidental dosimetry is a new concept. Since the materials used in fluorescent lamps are good photo luminescent materials, if one can either use the inherent defects present in the phosphor or add suitable modifiers to induce thermoluminescence (TL) in these phosphors, then the device (fluorescent lamp) can be used as an accidental dosemeter. In continuation of our search for a suitable phosphor material, which can serve both as an efficient lamp phosphor and as a good radiation monitoring device, detailed examination has been carried out on cerium and terbium-doped lanthanum phosphate material. A 90 Sr beta source with 50 mCi strength (1.85 GBq) was used as the irradiation source for TL studies. The TL response as a function of dose received was examined for all phosphors used and it was observed that the intensity of the TL peak vs. dose received was a linear function in the dose range 0.1-200 Gy in each case. Incidentally LaPO 4 :Ce,Tb is a component of the compact fluorescent lamp marketed recently as an energy bright light source. Besides having very good luminescence efficiency, good dosimetric properties of these phosphors render them useful for their use in accidental dosimetry also. (authors)

Effect of grinding on photostimuable phosphors for x-ray screens

International Nuclear Information System (INIS)

Rao, R.B.

1988-01-01

Luminescence efficiency of a phosphor can be improved by minimizing the energy losses during excitation. The loss of excitation energy in the case of powdered samples is mainly due to scattering of incident radiation by the particles of phosphor. Thus, while considering the industrial applications of polycrystalline phosphors in lamps, screens, paints, etc., the effect of particle size on the light output has to be specially studied. It is very well established that the radiographic imaging with photostimuable (PS) phosphors has many advantages over conventional photographic film screens. In the new type of computer radiography, PS phosphors are to be used as memory materials for temporary storage of the x-ray image. Eu(2+) doped barium fluorohalide phosphors are most suitable for this purpose. The spatial resolution from the image plate can be improved to a certain extent with phosphors comprising fine particles. The fineness of the particles can be achieved by various means such as grinding, fast cooling after firing or incorporation of some flux materials during the firing processes. But the efficiency of the phosphor deteriorates with grinding. Fast cooling is a complicated process in the case of Eu(2+) doped phosphors. Incorporation of flux materials may change the characteristics of phosphor materials. In the present investigation, effect of grinding (ball milling) on particle size distribution, shape of the particles and luminescent properties of BaFCl phosphors have been studied

Update History of This Database - TP Atlas | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...List Contact us TP Atlas Update History of This Database Date Update contents 2013/12/16 The email address i...s ( http://www.tanpaku.org/tpatlas/ ) is opened. About This Database Database Description Download License Update History of Thi...s Database Site Policy | Contact Us Update History of This Database - TP Atlas | LSDB Archive ... ...n the contact information is corrected. 2013/11/19 TP Atlas English archive site is opened. 2008/4/1 TP Atla

High efficiency nitride based phosphores for white LEDs

NARCIS (Netherlands)

Li, Yuan Qiang; Hintzen, H.T.J.M.

2008-01-01

In this overview paper, novel rare-earth doped silicon nitride based phosphors for white LEDs applications have been demonstrated. The luminescence properties of orange-red-emitting phosphors (M2Si5N8:Eu2+) and green-to-yellow emitting phosphors (MSi2N2O2:Eu2+, M = Ca, Sr, Ba) are discussed in

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth.

Science.gov (United States)

Haricharan, Svasti; Brown, Powel

2015-06-23

Breast cancer is a leading cause of cancer-related death, and it is important to understand pathways that drive the disease to devise effective therapeutic strategies. Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell growth differentially based on the presence of TP53, a tumor suppressor. TP53 is mutationally inactivated in most types of cancer and is mutated in 30-50% of diagnosed breast tumors. We demonstrate that TLR4 activation inhibits growth of TP53 wild-type cells, but promotes growth of TP53 mutant breast cancer cells by regulating proliferation. This differential effect is mediated by changes in tumor cell cytokine secretion. Whereas TLR4 activation in TP53 mutant breast cancer cells increases secretion of progrowth cytokines, TLR4 activation in TP53 wild-type breast cancer cells increases type I IFN (IFN-γ) secretion, which is both necessary and sufficient for mediating TLR4-induced growth inhibition. This study identifies a novel dichotomous role for TLR4 as a growth regulator and a modulator of tumor microenvironment in breast tumors. These results have translational relevance, demonstrating that TP53 mutant breast tumor growth can be suppressed by pharmacologic TLR4 inhibition, whereas TLR4 inhibitors may in fact promote growth of TP53 wild-type tumors. Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the effect of TP53 mutational status on TLR4 activity may extend to ovarian, colon, and lung cancers, among others, suggesting that the viability of TLR4 as a therapeutic target depends on TP53 status in many different tumor types.

Tm3+ activated lanthanum phosphate: a blue PDP phosphor

International Nuclear Information System (INIS)

Rao, R.P.

2005-01-01

Plasma display panels (PDPs) are gaining attention due to their high performance and scalability as a medium for large format TVs. The performance and life of a PDP strongly depends upon the nature of phosphors. Currently, Eu 2+ activated barium magnesium aluminate (BAM) is being used as a blue component. Because of its low life, efforts are being made to explore new blue emitting phosphors. One of the alternatives to BAM is Tm 3+ activated lanthanum phosphate (LPTM) phosphor. LPTM phosphor samples are prepared by a solid-state as well as sol-gel process in presence of flux. The phosphor of the present investigation, having uniform and spherical shape particles in the range of 0.1-2 μm, is appropriate for thin phosphor screens required for PDP applications. It exhibits a narrow band emission in the blue region, peaking at 452 nm and also a number of narrow bands in the UV region when excited by 147 and 173 nm radiation from a xenon gas mixture. Various possible transitions responsible for UV and visible emission from Tm 3+ ion are presented. These phosphors also exhibit good color saturation and better stability when excited with VUV radiation. To achieve higher brightness, they are blended with other UV excited blue emitting phosphors such as BAM. Results related to morphology, excitation, after glow decay, emission and degradation of these phosphors in the powder form as well as in plasma display panels are presented and discussed

Method of recovering phosphoric acid type decontaminating electrolytes by electrodeposition

International Nuclear Information System (INIS)

Sasaki, Takashi; Wada, Koichi; Kobayashi, Toshio.

1985-01-01

Purpose: To recoving phosphoric acid type highly concentrated decontaminating liquid used for the electrolytic decontamination of contaminated equipments, components, etc in nuclear power plants or the like through electrodeposition by diaphragm electrolysis. Method: Before supplying phosphoric acid decontaminating liquid at high concentration used in the electrolytic decontaminating step to an electrodeposition recovering tank, phosphoric acid in the decontaminating electrolyte is extracted with solvents and decomposed liquid extracts (electrolyte reduced with the phosphoric acid component) are supplied to the cathode chamber of the electrodeposition recovering tank, where phosphoric acid is back-extracted with water from the solvents after extraction of phosphoric acid. Then, the back-extracted liquids (aqueous phosphoric acid solution scarcely containing metal ions) are sent to the anode chamber of the electrodeposition recovering tank. Metal ions in the liquid are captured by electrodeposition in the cathode chamber, as well as phosphoric acid in the liquids is concentrated to the initial concentration of the electrolyte in the anode chamber for reuse as the decontaminating electrolyte. As the phosphoric acid extracting agent used in the electrodeposition recovering step for the decontaminating electrolyte, water-insoluble and non-combustible tributyl phosphate (TBP) is most effective. (Horiuchi, T.)

Rare-earth doped phosphors: oldies or goldies?

International Nuclear Information System (INIS)

Moine, B.; Bizarri, G.

2003-01-01

The scientific research on phosphors has a long history starting more than 100 years ago. But recently the appearance of new kinds of displays and lighting devices (plasma display, fluorescent lamp without mercury, etc.) induced an increase of the research of new phosphors with better luminous efficiency than those available up to now. It has been shown that the behavior of 'classical' phosphors in a plasma display panel is quite different than in a cathode ray tube and that the vacuum ultraviolet (VUV) excitation process has to be studied with care in order to improve the phosphors efficiency. That is particularly true in PDPs. It is well established now that a good phosphor for electronic or ultraviolet excitation is not necessarily a good choice for excitation in VUV. This is probably due to the fact that the excitation process is very different in that case and also because the penetration depth of the VUV photons is extremely small inducing a large contribution of the surface of the phosphor. We will illustrate this with some examples. Methods to accelerate luminous intensity decrease under VUV excitation will be described. Low efficiency, fast aging process are both drawbacks that can be solved only in the framework of fundamental studies. Quantum cutting emission may be a solution for the first one but no satisfactory process was proposed for the moment to solve the second

White-electroluminescent device with horizontally patterned blue/yellow phosphor-layer structure

International Nuclear Information System (INIS)

Won Park, Boo; Sik Choi, Nam; Won Park, Kwang; Mo Son, So; Kim, Jong Su; Kyun Shon, Pong

2007-01-01

White-electroluminescent (EL) devices with stripe-patterned and square-patterned phosphor-layer structures are fabricated through a screen printing method: electrode/BaTiO 3 insulator layer/patterned blue ZnS:Cu, Cl and yellow ZnS:Cu, Mn phosphor layer/ITO PET substrate. The luminous intensities of EL devices with stripe-patterned and square-patterned phosphor-layer structures are 33% and 23% higher than a conventional device with the phosphor-layer structure without any patterns using the phosphor blend. It can be explained in terms of the absorption of the emitted blue light of blue phosphor layer by the yellow-emitting phosphor layer. The EL device of our patterned phosphor-layer structure gives the possibility to enhance the luminance

Photoluminescence of phosphors for PDP with VUV excitation

International Nuclear Information System (INIS)

Lu, H.-C.; Chen, H.-K.; Tseng, T.-Y.; Kuo, W.-L.; Alam, M.S.; Cheng, B.-M.

2005-01-01

In a plasma display panel (PDP) He-Xe or Ne-Xe gaseous mixtures are subjected to electric discharge between two glass panels, so to generate VUV light. Red, green and blue phosphors absorb this VUV radiation and re-radiate the energy as visible light to produce the colors that appear on the screen. The phosphor plays an important role in the working of a PDP. To improve the efficiency of phosphors, we have established a photoluminescence end station coupled to the beam line of a synchrotron to study the luminescence of PDP phosphors. This luminescence is analyzed with a 0.32 m monochromator having maximum resolution 0.04 nm, and is monitored with a photomultiplier tube operated in a photon-counting mode. Preliminary data demonstrate the powerful performance of this end-station for studying PDP phosphors

High Extraction Phosphors for Solid State Lighting

Energy Technology Data Exchange (ETDEWEB)

Summers, Chris [Phosphortech Corporation, Kennesaw, GA (United States); Menkara, Hisham [Phosphortech Corporation, Kennesaw, GA (United States); Wagner, Brent [Phosphortech Corporation, Kennesaw, GA (United States)

2011-09-01

We have developed high-index, high efficiency bulk luminescent materials and novel nano-sized phosphors for improved solid-state white LED lamps. These advances can potentially contribute to reducing the loss in luminous efficiencies due to scattering, re-absorption, and thermal quenching. The bulk and nanostructured luminescent materials investigated are index matched to GaN and have broad and size-tunable absorption bands, size and impurity tuned emission bands, size-driven elimination of scattering effects, and a separation between absorption and emission bands. These innovations were accomplished through the use of novel synthesis techniques suitable for high volume production for LED lamp applications. The program produced a full-color set of high quantum yield phosphors with high chemical stability. In the bulk phosphor study, the ZnSeS:Cu,Ag phosphor was optimized to achieve >91% efficiency using erbium (Er) and other activators as sensitizers. Detailed analysis of temperature quenching effects on a large number of ZnSeS:Cu,Ag,X and strontium- and calcium-thiogallate phosphors lead to a breakthrough in the understanding of the anti-quenching behavior and a physical bandgap model was developed of this phenomena. In a follow up to this study, optimized phosphor blends for high efficiency and color performance were developed and demonstrated a 2-component phosphor system with good white chromaticity, color temperature, and high color rendering. By extending the protocols of quantum dot synthesis, large nanocrystals, greater than 20 nm in diameter were synthesized and exhibited bulk-like behavior and blue light absorption. The optimization of ZnSe:Mn nanophosphors achieved ~85% QE The limitations of core-shell nanocrystal systems were addressed by investigating alternative deltadoped structures. To address the manufacturability of these systems, a one-pot manufacturing protocol was developed for ZnSe:Mn nanophosphors. To enhance the stability of these material

Electrolyte Additives for Phosphoric Acid Fuel Cells

DEFF Research Database (Denmark)

Gang, Xiao; Hjuler, H.A.; Olsen, C.A.

1993-01-01

, as a fuel-cell performance with the modified electrolytes. Specific conductivity measurements of some of the modified phosphoric acid electrolytes are reported. At a given temperature, the conductivity of the C4F9SO3K-modified electrolyte decreases with an increasing amount of the additive; the conductivity...... of the remains at the same value as the conductivity of the pure phosphoric acid. At a given composition, the conductivity of any modified electrolyte increases with temperature. We conclude that the improved cell performance for modified electrolytes is not due to any increase in conductivity.......Electrochemical characteristics of a series of modified phosphoric acid electrolytes containing fluorinated car on compounds and silicone fluids as additives are presented. When used in phosphoric acid fuel cells, the modified electrolytes improve the performance due to the enhanced oxygen...

Crystal growth of electroluminescent ZnS:Cu,Cl phosphor and its TiO2 coating by sol-gel method for thick-film EL device

International Nuclear Information System (INIS)

Han, Sang-Do; Singh, Ishwar; Singh, Devender; Lee, You-He; Sharma, Gaytri; Han, Chi-Hwan

2005-01-01

Bigger-sized spherical particle of ZnS:Cu,Cl to be employed for electroluminescent (EL) device has been synthesized using a new eutectic mixture as flux. The best composition of the flux was the mixture of BaCl 2 .2H 2 O, MgCl 2 .6H 2 O and NaCl in the mole percentage ratio of 13.8:39.9:46.2 and when the total amount of the mixture was 6% of the total weight of ZnS. The phosphor was synthesized firing at higher temperatures in two steps. First step firing at 1150 deg. C gave the hexagonal phase of the ZnS phosphor particles. Low intensity ball-milling of the phosphor pastes in solvents converted hexagonal phase partially to the cubic phase of the phosphor, which is an essential step. Mixing with copper sulfate or copper(I) halides and magnesium chloride and then firing (second step) at 750 deg. C gave a phosphor with better luminescent characteristics and converting to almost 100% cubic phase. The phosphor particles having size >0.020 mm size were sieved and coated with TiO 2 made by sol-gel process using titanium(IV)-isopropoxide as a precursor. The phosphor particles were coated twice with the TiO 2 sol and finally calcined at 400 deg C in nitrogen atmosphere. The EL devices were fabricated with the synthesized phosphor using a screen-printing method

Process for winning uranium from wet process phosphoric acid

International Nuclear Information System (INIS)

1980-01-01

A process is described for winning uranium from wet process phosphoric acid by means of liquid-liquid extraction with organic phosphoric acid esters. The process is optimised by keeping the sulphate percentage in the phosphoric acid below 2% by weight, and preferably below 0.6% by weight, as compared to P 2 O 5 in the phosphoric acid. This is achieved by adding an excess of Ba and/or Ca carbonate or sulfide solution and filtering off the formed calcium and/or barium sulphate precipitates. Solid KClO 3 is then added to the filtrate to oxidise U 4+ to U 6+ . The normal extraction procedure using organic phosphoric esters as extraction liquid, can then be applied. (Th.P.)

Agronomic behavior of phosphoric rock from Bahia Inglesa using isotopic techniques. 1. Field trial with concentrated and non concentrated rock

International Nuclear Information System (INIS)

Pino N, I.; Casa G, L.

1989-01-01

With the aim to assess the agronomic behaviour of the phosphoric rock from Bahia Inglesa, a field trial was carried out with concentrated and non concentrated 100 mesh sieved rock. The method of isotopic dilution was used with TSP labeled P32 (TSP-P32) as standard fertilizer. Total dry matter, total P by colorimetry and P32 by liquid scintillation using the Cerenkov effect were measured. Both agronomic and isotope parameters were analyzed. The concentrated phosphoric rock was 3.7 times better than the same non concentrated rock. These also was a positive effect from non concentrated at 400 kg P205/ha dose. This effect was attributed to a higher saturation in the points of P sorption. The TSP showed a better behaviour than the phosphoric rock under study. (author)

Total Pancreatectomy and Islet Auto-Transplantation in Children for Chronic Pancreatitis. Indication, Surgical Techniques, Post Operative Management and Long-Term Outcomes

Science.gov (United States)

Chinnakotla, Srinath; Bellin, Melena D.; Schwarzenberg, Sarah J.; Radosevich, David M.; Cook, Marie; Dunn, Ty B.; Beilman, Gregory J.; Freeman, Martin L.; Balamurugan, A.N.; Wilhelm, Josh; Bland, Barbara; Jimenez-Vega, Jose M; Hering, Bernhard J.; Vickers, Selwyn M.; Pruett, Timothy L.; Sutherland, David E.R.

2014-01-01

Objective Describe the surgical technique, complications and long term outcomes of total pancreatectomy and islet auto transplantation (TP-IAT) in a large series of pediatric patients. Summary Background Data Surgical management of childhood pancreatitis is not clear; partial resection or drainage procedures often provide transient pain relief, but long term recurrence is common due to the diffuse involvement of the pancreas. Total pancreatectomy (TP) removes the source of the pain, while islet auto transplantation (IAT) potentially can prevent or minimize TP-related diabetes. Methods Retrospective review of 75 children undergoing TP-IAT for chronic pancreatitis who had failed medical, endoscopic or surgical treatment between 1989–2012. Results Pancreatitis pain and the severity of pain statistically improved in 90% of patients after TP-IAT (p =Puestow (p=0.018), lower body surface area (p=0.048), IEQ per Kg Body Weight (p=0.001) and total IEQ (100,000) (0.004) were associated with insulin independence. By multivariate analysis, 3 factors were associated with insulin independence after TP-IAT:(1) male gender, (2) lower body surface area and the (3) higher total IEQ per kilogram body weight. Total IEQ (100,000) was the single factor most strongly associated with insulin independence (OR = 2.62; p value < 0.001). Conclusions TP-IAT provides sustained pain relief and improved quality of life. The β cell function is dependent on islet yield. TP-IAT is an effective therapy for children with painful pancreatitis that fail medical and or endoscopic management PMID:24509206

Industrial radiography with phosphor screens

International Nuclear Information System (INIS)

Broadhead, P.

1981-01-01

An experimental system that comprises a film of low silver content and a pair of high resolution phosphor intensifying screens and a commercial industrial X-ray film of similar speed are compared for image quality. It is concluded that the use of phosphor screens offers an increase in image quality when the information is limited by the graininess or quantum mottle of a radiograph which is frequently the case in practical radiography. (author)

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

International Nuclear Information System (INIS)

Anthoney, D Alan; Miwa, Masanori; Twelves, Christopher; Evans, TRJ; Naik, Jay; MacPherson, Iain RJ; Crawford, Donna; Hartley, John M; Hartley, Janet A; Saito, Tomohisa; Abe, Masaichi; Jones, Keith

2012-01-01

A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of TP300, a water soluble prodrug of the Topo-1 inhibitor TP3076, and active metabolite, TP3011. Eligible patients with refractory advanced solid tumors, adequate performance status, haematologic, renal, and hepatic function. TP300 was given as a 1-hour i.v. infusion 3-weekly and pharmacokinetic (PK) profiles of TP300, TP3076 and TP3011 were analysed. Polymorphisms in CYP2D6, AOX1 and UGT1A1 were studied and DNA strand-breaks measured in peripheral blood mononuclear cells (PBMCs). 32 patients received TP300 at 1, 2, 4, 6, 8, 10, 12 mg/m 2 . MTD was 10 mg/m 2 ; DLTs at 12 (2/4 patients) and 10 mg/m 2 (3/12) included thrombocytopenia and febrile neutropenia; diarrhoea was uncommon. Six patients (five had received irinotecan), had stable disease for 1.5-5 months. TP3076 showed dose proportionality in AUC and C max from 1–10 mg/m 2 . Genetic polymorphisms had no apparent influence on exposure. DNA strand-breaks were detected after TP300 infusion. TP300 had predictable hematologic toxicity, and diarrhoea was uncommon. AUC at MTD is substantially greater than for SN38. TP3076 and TP3011 are equi-potent with SN38, suggesting a PK advantage. EU-CTR2006-001345-33

Phosphate phosphors for solid-state lighting

Energy Technology Data Exchange (ETDEWEB)

Shinde, Kartik N. [N.S. Science and Arts College, Bhadrawati (India). Dept. of Physics; Swart, H.C. [University of the Orange Free State, Bloemfontein (South Africa). Dept. of Physics; Dhoble, S.J. [R.T.M. Nagpur Univ. (India). Dept. of Physics; Park, Kyeongsoon [Sejong Univ., Seoul (Korea, Republic of). Faculty of Nanotechnology and Advanced Materials Engineering

2012-07-01

Essential information for students in researchers working towards new and more efficient solid-state lighting. Comprehensive survey based on the authors' long experience. Useful both for teaching and reference. The idea for this book arose out of the realization that, although excellent surveys and a phosphor handbook are available, there is no single source covering the area of phosphate based phosphors especially for lamp industry. Moreover, as this field gets only limited attention in most general books on luminescence, there is a clear need for a book in which attention is specifically directed toward this rapidly growing field of solid state lighting and its many applications. This book is aimed at providing a sound introduction to the synthesis and optical characterization of phosphate phosphor for undergraduate and graduate students as well as teachers and researchers. The book provides guidance through the multidisciplinary field of solid state lighting specially phosphate phosphors for beginners, scientists and engineers from universities, research organizations, and especially industry. In order to make it useful for a wide audience, both fundamentals and applications are discussed, together.

A SrBPO5: Eu2+ phosphor for neutron imaging

International Nuclear Information System (INIS)

Sakasai, K.; Katagiri, M.; Toh, K.; Nakamura, T.

2001-01-01

A SrBPO 5 : Eu 2+ phosphor material has been investigated for neutron imaging. This phosphor showed photostimulated luminescence (PSL) by illumination of 635 nm laser light after X-ray irradiation. The spectral characteristics of the phosphor were similar to those of BaFBr: Eu 2+ , which is a commonly used phosphor of imaging plates. In addition, we found that this phosphor also showed PSL for neutron irradiation. It comes from the fact that it contains atomic boron in base matrix. Therefore, this phosphor can be used for neutron imaging without adding neutron sensitive materials such as Gd in commercially available neutron imaging plates. The PSL intensity and the neutron detection will be increased by using enriched boron instead of natural boron. (author)

Studies on organic carbon, nitrogen and phosphorous in the sediments of Mandovi Estuary, Goa

Digital Repository Service at National Institute of Oceanography (India)

Nasnolkar, C.M.; Shirodkar, P.V.; Singbal, S.Y.S.

indicated a significant linear variation with clay and silt. The organic carbon varies from 1.04 to 32.77 mg.g sup(-1) and the total nitrogen and total phosphorous varies from 3.81 to 32.71 mg.g sup(-1) and from 0.46 to 6.74 mg.g sup(-1) respectively. A...

CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53

International Nuclear Information System (INIS)

Taniguchi, Hidefumi; Ito, Saya; Ueda, Takashi; Morioka, Yukako; Kayukawa, Naruhiro; Ueno, Akihisa; Nakagawa, Hideo; Fujihara, Atsuko; Ushijima, So; Kanazawa, Motohiro; Hongo, Fumiya; Ukimura, Osamu

2017-01-01

Renal cell carcinoma (RCC) is the most common type of kidney cancer. However, the mechanisms underlying the progression of the disease are not well understood. The data in this report suggest that canopy FGF signaling regulator 2 (CNPY2) is a promoter of RCC progression. We found that CNPY2 significantly promoted growth of RCC cells and upregulated TP53 gene expression. Although TP53 is widely known as a tumor suppressor, in RCC TP53 promoted tumor cell growth. A typical p53 target gene, CDKN1A, was upregulated by both p53 and CNPY2 in RCC cells, suggesting that CNPY2 increased the expression level of TP53. Consistent with these results, CNPY2 and TP53 expression levels were positively correlated in RCC patients. These findings suggested that CNPY2 promoted cancer cell growth in RCC through regulating TP53 gene expression. - Highlights: • CNPY2 promoted growth of renal cell carcinoma (RCC) cells. • TP53 expression levels were increased by CNPY2 in RCC cells. • Growth of RCC cells was promoted by TP53. • CNPY2 expression positively correlated with TP53 expression in RCC patients.

TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth

OpenAIRE

Haricharan, Svasti; Brown, Powel

2015-01-01

This study fundamentally alters our understanding of how TLR4 drives breast cancer. Although TLR4 was previously considered a tumor promoter, we demonstrate a complex, TP53-dependent role for TLR4 in regulating tumor growth. TP53 is a tumor suppressor commonly inactivated across cancer types. In TP53 wild-type cancer cells, TLR4 activation causes secretion of IFN-γ into the microenvironment, resulting in induction of p21 and inhibition of cell growth. Conversely, TLR4 activation in TP53 mutan...

Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes.

Science.gov (United States)

Chinnakotla, Srinath; Bellin, Melena D; Schwarzenberg, Sarah J; Radosevich, David M; Cook, Marie; Dunn, Ty B; Beilman, Gregory J; Freeman, Martin L; Balamurugan, A N; Wilhelm, Josh; Bland, Barbara; Jimenez-Vega, Jose M; Hering, Bernhard J; Vickers, Selwyn M; Pruett, Timothy L; Sutherland, David E R

2014-07-01

Describe the surgical technique, complications, and long-term outcomes of total pancreatectomy and islet autotransplantation (TP-IAT) in a large series of pediatric patients. Surgical management of childhood pancreatitis is not clear; partial resection or drainage procedures often provide transient pain relief, but long-term recurrence is common due to the diffuse involvement of the pancreas. Total pancreatectomy (TP) removes the source of the pain, whereas islet autotransplantation (IAT) potentially can prevent or minimize TP-related diabetes. Retrospective review of 75 children undergoing TP-IAT for chronic pancreatitis who had failed medical, endoscopic, or surgical treatment between 1989 and 2012. Pancreatitis pain and the severity of pain statistically improved in 90% of patients after TP-IAT (P Puestow procedure (P = 0.018), lower body surface area (P = 0.048), higher islet equivalents (IEQ) per kilogram body weight (P = 0.001), and total IEQ (100,000) (P = 0.004) were associated with insulin independence. By multivariate analysis, 3 factors were associated with insulin independence after TP-IAT: (1) male sex, (2) lower body surface area, and (3) higher total IEQ per kilogram body weight. Total IEQ (100,000) was the single factor most strongly associated with insulin independence (odds ratio = 2.62; P < 0.001). Total pancreatectomy and islet autotransplantation provides sustained pain relief and improved quality of life. The β-cell function is dependent on islet yield. Total pancreatectomy and islet autotransplantation is an effective therapy for children with painful pancreatitis that failed medical and/or endoscopic management.

High resolution melting for mutation scanning of TP53 exons 5–8

International Nuclear Information System (INIS)

Krypuy, Michael; Dobrovic, Alexander; Ahmed, Ahmed Ashour; Etemadmoghadam, Dariush; Hyland, Sarah J; Australian Ovarian Cancer Study Group; Fazio, Anna de; Fox, Stephen B; Brenton, James D; Bowtell, David D

2007-01-01

p53 is commonly inactivated by mutations in the DNA-binding domain in a wide range of cancers. As mutant p53 often influences response to therapy, effective and rapid methods to scan for mutations in TP53 are likely to be of clinical value. We therefore evaluated the use of high resolution melting (HRM) as a rapid mutation scanning tool for TP53 in tumour samples. We designed PCR amplicons for HRM mutation scanning of TP53 exons 5 to 8 and tested them with DNA from cell lines hemizygous or homozygous for known mutations. We assessed the sensitivity of each PCR amplicon using dilutions of cell line DNA in normal wild-type DNA. We then performed a blinded assessment on ovarian tumour DNA samples that had been previously sequenced for mutations in TP53 to assess the sensitivity and positive predictive value of the HRM technique. We also performed HRM analysis on breast tumour DNA samples with unknown TP53 mutation status. One cell line mutation was not readily observed when exon 5 was amplified. As exon 5 contained multiple melting domains, we divided the exon into two amplicons for further screening. Sequence changes were also introduced into some of the primers to improve the melting characteristics of the amplicon. Aberrant HRM curves indicative of TP53 mutations were observed for each of the samples in the ovarian tumour DNA panel. Comparison of the HRM results with the sequencing results revealed that each mutation was detected by HRM in the correct exon. For the breast tumour panel, we detected seven aberrant melt profiles by HRM and subsequent sequencing confirmed the presence of these and no other mutations in the predicted exons. HRM is an effective technique for simple and rapid scanning of TP53 mutations that can markedly reduce the amount of sequencing required in mutational studies of TP53

Pretreatment of phosphoric acid of Annaba

International Nuclear Information System (INIS)

Kada, R.

1990-03-01

The most important step in the process of uranium recovery from phosphoric acid is the pretreatment operation. In this study, the adsorption of organic matters on activated carbon was carried out in a batch process and in a fixed bed column. First, the chemical and physical characterization of phosphoric acid, activated carbon and gypsum were performed. In addition, the organic matters were qualitatively analysed and a new and original quantitative method was experimented. Next, the various operating parameters such as agitation speed, granulometry, temperature, solid/liquid ratio, initial concentration, acid flowrate, and bed height were optimized. The experimental equilibrium isotherm was compared to the Langmuir, Freundlich, and Redlich-Peterson theoretical isotherms. It was noticed that the three models did not fit the experimental isotherm in the total concentration range. Thus, an original bilinear model was proposed. The influence of the operating conditions on the adsorption kinetics was also investigated. As a result of that, a new mathematical model was proposed to determine both the liquid and solid phases mass transfer and the solid phase diffusion coefficient. Finally, adsorption of organic matters on a fixed bed process allowed computation of the number of transfer units (NTU), the height of adsorption zone and the degree of saturation of activated carbon

TMACS Test Procedure TP011: Panalarm Interface

International Nuclear Information System (INIS)

Seghers, R.; Washburn, S.J.

1994-01-01

The TMACS Software Test Procedures translate the project's acceptance criteria into test steps. The TMACS Test Plan (WHC-SD-WM-TP-148) is fulfilled when all Test Cases are approved. This Test Procedure tests the TMACS Panalarm Interface functions

Encapsulation of strontium aluminate phosphors to enhance water resistance and luminescence

International Nuclear Information System (INIS)

Zhu Yong; Zeng Jianghua; Li Wenyu; Xu Li; Guan Qiu; Liu Yingliang

2009-01-01

Strontium aluminate SrAl 2 O 4 :Eu 2+ ,Dy 3+ phosphors are chemically unstable against water or even moisture. To enhance the water resistance of the phosphors, an encapsulation was performed by direct surface reactions with phosphoric acid (H 3 PO 4 ). The morphology, surface structure, surface element composition, water resistance, luminescence, and photoacoustic spectrum of the phosphors before and after encapsulation were discussed. Experimental results showed that phosphors were perfectly encapsulated by amorphous layers in nanoscale and crystalline layers in microscale under different conditions. The water resistance of phosphors was greatly enhanced by the two types of layer. More importantly, the amorphous layers enhanced the luminescence of phosphors markedly. The possible mechanism for the enhancements was also proposed.

Genetic variation in the TP53 pathway and bladder cancer risk. a comprehensive analysis.

Directory of Open Access Journals (Sweden)

Silvia Pineda

Full Text Available Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other related genes, including TP53 rs1042522 (Arg72Pro, still present controversial results. We carried out an in depth assessment of associations between common germline variants in the TP53 pathway and bladder cancer risk.We investigated 184 tagSNPs from 18 genes in 1,058 cases and 1,138 controls from the Spanish Bladder Cancer/EPICURO Study. Cases were newly-diagnosed bladder cancer patients during 1998-2001. Hospital controls were age-gender, and area matched to cases. SNPs were genotyped in blood DNA using Illumina Golden Gate and TaqMan assays. Cases were subphenotyped according to stage/grade and tumor p53 expression. We applied classical tests to assess individual SNP associations and the Least Absolute Shrinkage and Selection Operator (LASSO-penalized logistic regression analysis to assess multiple SNPs simultaneously.Based on classical analyses, SNPs in BAK1 (1, IGF1R (5, P53AIP1 (1, PMAIP1 (2, SERINPB5 (3, TP63 (3, and TP73 (1 showed significant associations at p-value≤0.05. However, no evidence of association, either with overall risk or with specific disease subtypes, was observed after correction for multiple testing (p-value≥0.8. LASSO selected the SNP rs6567355 in SERPINB5 with 83% of reproducibility. This SNP provided an OR = 1.21, 95%CI 1.05-1.38, p-value = 0.006, and a corrected p-value = 0.5 when controlling for over-estimation.We found no strong evidence that common variants in the TP53 pathway are associated with bladder cancer susceptibility. Our study suggests that it is unlikely that TP53 Arg72Pro is implicated in the UCB in white Europeans. SERPINB5 and TP63 variation deserve further exploration in extended studies.

Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer

DEFF Research Database (Denmark)

Holmila, Reetta; Bornholdt, Jette; Heikkilä, Pirjo

2010-01-01

The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure...... affected the ORs only slightly. Smoking did not influence the occurrence of TP53 mutation; however, it was associated with multiple mutations (p = 0.03). As far as we are aware, this is the first study to demonstrate a high prevalence of TP53 mutation-positive cases in a large collection of sinonasal...... cancers with data on occupational exposure. Our results indicate that mutational mechanisms, in particular TP53 mutations, are associated with work-related exposure to wood dust in sinonasal cancer....

Photocatalytic effects for the TiO2-coated phosphor materials

International Nuclear Information System (INIS)

Yoon, Jin-Ho; Jung, Sang-Chul; Kim, Jung-Sik

2011-01-01

Research highlights: → The photocatalytic behavior of the coupling of TiO 2 with phosphorescent materials. → The photobleaching of an MB aqueous solution under visible light irradiation. → The ALD TiO 2 -coated phosphor composite showed much higher photocatalytic reactivity. → The light emitted from the phosphors contributed to the photo-generation. - Abstract: This study investigated the photocatalytic behavior of the coupling of TiO 2 with phosphorescent materials. A TiO 2 thin film was deposited on CaAl 2 O 4 :Eu 2+ ,Nd 3+ phosphor particles by using atomic layer deposition (ALD), and its photocatalytic reaction was investigated by the photobleaching of an aqueous solution of methylene-blue (MB) under visible light irradiation. To clarify the mechanism of the TiO 2 -phosphorescent materials, two different samples of TiO 2 -coated phosphor and TiO 2 -Al 2 O 3 -coated phosphor particles were prepared. The photocatalytic mechanisms of the ALD TiO 2 -coated phosphor powders were different from those of the pure TiO 2 and TiO 2 -Al 2 O 3 -coated phosphor. The absorbance in a solution of the ALD TiO 2 -coated phosphor decreased much faster than that of pure TiO 2 under visible irradiation. In addition, the ALD TiO 2 -coated phosphor showed moderately higher photocatalytic degradation of MB solution than the TiO 2 -Al 2 O 3 -coated phosphor did. The TiO 2 -coated phosphorescent materials were characterized by transmission electron microscopy (TEM), Auger electron spectroscopy (AES) and X-ray photon spectroscopy (XPS).

Investigation of the synergic effect of some neutral organophosphoric compounds on the extraction of uranium from phosphoric acid solutions by D1-(2-Ethyl Hexyl) phosphoric acid

International Nuclear Information System (INIS)

Stas, J.; Khorfan, S.; Koudsi, Y.

1998-05-01

The extraction of uranium (VI) from pure phosphoric acid media by D2EHPA/Kerosene has been studied. The mechanism of the extraction was found as follows: The logarithm of the equilibrium constant of the extraction (LogKex) was found (3.06), (3.32), (3.24), (3.3) for the following phosphoric acid concentrations respectively (1), (2), (3), (4) Mol/1, and the enthalpy change DELTA H was found (-100.68 kj/mol). (-76 kj/mol) for (1), (2) mol/1 phosphoric acid concentrations. The synergic effect of TOPO, TBP, and TBPI with DEHPA have been studied during the extraction of uranium from pure phosphoric acid and Syrian commercial phosphoric acid. The synergic effect increases as follows: TBP< TBPI<< TOPO (In pure phosphoric acid), TBPI approx TBP<< TOPO (In Syrian commercial phosphoric acid). The difficulty of extracting uranium (VI) from Syrian commercial phosphoric acid in comparison with pure phosphoric acid is due to the presence of several impurities capable of complexing uranium, and a small amounts of solid and organic matters, all these are factors which reduce the distribution coefficient of uranium. (Author)

Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.

Science.gov (United States)

Dong, Zhiyong; Zheng, Longzhi; Liu, Weimin; Wang, Cunchuan

2018-01-01

The relationship between TP53 codon 72 Pro/Arg gene polymorphism and colorectal cancer risk in Asians is still controversial, and this bioinformatics analysis and meta-analysis was performed to assess the associations. The association studies were identified from PubMed, and eligible reports were included. RevMan 5.3.1 software, Oncolnc, cBioPortal, and Oncomine online tools were used for statistical analysis. A random/fixed effects model was used in meta-analysis. The data were reported as risk ratios or mean differences with corresponding 95% CI. We confirmed that TP53 was associated with colorectal cancer, the alteration frequency of TP53 was 53% mutation and 7% deep deletion, and TP53 mRNA expression was different in different types of colorectal cancer based on The Cancer Genome Atlas database. Then, 18 studies were included that examine the association of TP53 codon 72 gene polymorphism with colorectal cancer risk in Asians. The meta-analysis indicated that TP53 Pro allele and Pro/Pro genotype were associated with colorectal cancer risk in Asian population, but Arg/Arg genotype was not (Pro allele: odds ratios [OR]=1.20, 95% CI: 1.06 to 1.35, P =0.003; Pro/Pro genotype: OR=1.39, 95% CI: 1.15 to 1.69, P =0.0007; Arg/Arg genotype: OR=0.86, 95% CI: 0.74 to 1.00, P =0.05). Interestingly, in the meta-analysis of the controls from the population-based studies, we found that TP53 codon 72 Pro/Arg gene polymorphism was associated with colorectal cancer risk (Pro allele: OR=1.33, 95% CI: 1.15 to 1.55, P =0.0002; Pro/Pro genotype: OR=1.61, 95% CI: 1.28 to 2.02, P colorectal cancer, but the different value levels of mRNA expression were not associated with survival rate of colon and rectal cancer. TP53 Pro allele and Pro/Pro genotype were associated with colorectal cancer risk in Asians.

Tumor protein 53-induced nuclear protein 1 (TP53INP1 enhances p53 function and represses tumorigenesis

Directory of Open Access Journals (Sweden)

Jeyran eShahbazi

2013-05-01

Full Text Available Tumor protein 53-induced nuclear protein 1 (TP53INP1 is a stress-induced p53 target gene whose expression is modulated by transcription factors such as p53, p73 and E2F1. TP53INP1 gene encodes two isoforms of TP53INP1 proteins, TP53INP1α and TP53INP1β, both of which appear to be key elements in p53 function. When associated with homeodomain-interacting protein kinase-2 (HIPK2, TP53INP1 phosphorylates p53 protein at Serine 46, enhances p53 protein stability and its transcriptional activity, leading to transcriptional activation of p53 target genes such as p21, PIG-3 and MDM2, cell growth arrest and apoptosis upon DNA damage stress. The anti-proliferative and pro-apoptotic activities of TP53INP1 indicate that TP53INP1 has an important role in cellular homeostasis and DNA damage response. Deficiency in TP53INP1 expression results in increased tumorigenesis; while TP53INP1 expression is repressed during early stages of cancer by factors such as miR-155. This review aims to summarize the roles of TP53INP1 in blocking tumor progression through p53-dependant and p53-independent pathways, as well as the elements which repress TP53INP1 expression, hence highlighting its potential as a therapeutic target in cancer treatment.

A survey of phosphors novel for thermography

Energy Technology Data Exchange (ETDEWEB)

Bruebach, J., E-mail: bruebach@ekt.tu-darmstadt.d [Fachgebiet Reaktive Stroemungen und Messtechnik, Center of Smart Interfaces Technische Universitaet Darmstadt, Petersenstrasse 32, 64287 Darmstadt (Germany); Kissel, T. [Fachgebiet Reaktive Stroemungen und Messtechnik, Center of Smart Interfaces Technische Universitaet Darmstadt, Petersenstrasse 32, 64287 Darmstadt (Germany); Frotscher, M. [Eduard-Zintl-Institut fuer Anorganische und Physikalische Chemie, Technische Universitaet Darmstadt, Petersenstrasse 18, 64287 Darmstadt (Germany); Euler, M. [Fachgebiet Reaktive Stroemungen und Messtechnik, Center of Smart Interfaces Technische Universitaet Darmstadt, Petersenstrasse 32, 64287 Darmstadt (Germany); Albert, B. [Eduard-Zintl-Institut fuer Anorganische und Physikalische Chemie, Technische Universitaet Darmstadt, Petersenstrasse 18, 64287 Darmstadt (Germany); Dreizler, A. [Fachgebiet Reaktive Stroemungen und Messtechnik, Center of Smart Interfaces Technische Universitaet Darmstadt, Petersenstrasse 32, 64287 Darmstadt (Germany)

2011-04-15

With regard to phosphor thermometry, seven luminescent ceramic materials were synthesised and characterised, namely CaMoO{sub 4}:Eu{sup 3+}, CaTiO{sub 3}:Pr{sup 3+}, LaPO{sub 4}:Eu{sup 3+}, LaVO{sub 4}:Eu{sup 3+}, LiAl{sub 5}O{sub 8}:Fe{sup 3+}, TiMg{sub 2}O{sub 4}:Mn{sup 4+} and ZnGa{sub 2}O{sub 4}:Mn{sup 2+}. In this context, emission spectra and temperature lifetime characteristics are presented. Thus, a survey of phosphors novel for thermography is given in order to encourage further studies and more detailed characterisations of the respective materials. - Research Highlights: Seven phosphor materials novel for thermometry were synthesised. These materials were characterised diffractometrically as well as concerning their emission spectra and lifetime temperature characteristics. The number of phosphor materials characterised for thermometry purposes was extended by seven materials.

Characteristics of the Panasonic UD-802 phosphors

International Nuclear Information System (INIS)

Ben-Shachar, B.; Catchen, G.L.; Hoffman, J.M.

1989-01-01

Several basic dosimetric characteristics of Li 2 B 4 O 7 :Cu and CaSO 4 :Tm phosphors in Panasonic UD-802 dosemeters were measured. The TL dose response linearity was determined over the useful range of personnel and environmental dosimetry (0.005 - 10 mGy), and the minimum measurable doses were calculated. The intrinsic ultraviolet (UV) radiation sensitivity of both phosphors was checked before and after γ irradiation for the purpose of re-assessing high doses. The results indicate that Li 2 B 4 O 7 :Cu is UV sensitive and, therefore, re-assessment is not applicable. Although the CaSO 4 :Tm phosphor exhibited UV sensitivity after γ irradiation, the results were not consistent with those reported earlier and more study is required. The fading of both phosphors was evaluated in Panasonic UD-801 dosemeters for periods up to 90 days. (author)

Improvements in phosphors

International Nuclear Information System (INIS)

Rabatin, J.G.

1981-01-01

For X-ray image converter applications, especially when used in medical radiography, it is desirable to improve the speed and brightness of response for conversion of X-rays in phosphors. The rare earth oxyhalide phosphors coactivated with a combination of rare earth activators described in this patent are capable of exhibiting low afterglow with high ultraviolet emission. They have the general formula Lnsub(1-y-w)OX:Tbsub(y)Tmsub(w) where Ln is lanthanum or gadolinium, X is chlorine and/or bromine, y is from 0.0005 to 0.010 moles per mole and w is from 0.00005 to 0.005 moles per mole of the Lnsub(1-y-w)OX host. The method of preparation and characteristics of speed, afterglow and UV emission are described. (U.K.)

Angle-resolved photoluminescence spectrum of a uniform phosphor layer

Science.gov (United States)

Fujieda, Ichiro; Ohta, Masamichi

2017-10-01

A photoluminescence spectrum depends on an emission angle due to self-absorption in a phosphor material. Assuming isotropic initial emission and Lambert-Beer's law, we have derived simple expressions for the angle-resolved spectra emerging from the top and bottom surfaces of a uniform phosphor layer. The transmittance of an excitation light through the phosphor layer can be regarded as a design parameter. For a strongly-absorbing phosphor layer, the forward flux is less intense and more red-shifted than the backward flux. The red-shift is enhanced as the emission direction deviates away from the plane normal. When we increase the transmittance, the backward flux decreases monotonically. The forward flux peaks at a certain transmittance value. The two fluxes become similar to each other for a weakly-absorbing phosphor layer. We have observed these behaviors in experiment. In a practical application, self-absorption decreases the efficiency of conversion and results in angle-dependent variations in chromaticity coordinates. A patterned phosphor layer with a secondary optical element such as a remote reflector alleviates these problems.

Investigation of saturation effects in ceramic phosphors for laser lighting

DEFF Research Database (Denmark)

Krasnoshchoka, Anastasiia; Thorseth, Anders; Dam-Hansen, Carsten

2017-01-01

We report observation of saturation effects in a Ce:LuAG and Eu-doped nitride ceramic phosphor for conversion of blue laser light for white light generation. The luminous flux from the phosphors material increases linearly with the input power until saturation effects limit the conversion....... It is shown, that the temperature of the phosphor layer influences the saturation power level and the conversion efficiency. It is also shown that the correlated color temperature (CCT), phosphor conversion efficiency and color rendering index (CRI) are dependent both on incident power and spot size diameter...... of the illumination. A phosphor conversion efficiency up to 140.8 lm/W with CRI of 89.4 was achieved. The saturation in a ceramic phosphor, when illuminated by high intensity laser diodes, is estimated to play the main role in limiting the available luminance from laser based lighting systems....

Biogeochemical Cycling of Iron and Phosphorous in Deep Saprolite

Science.gov (United States)

Buss, H. L.; Bruns, M. A.; Williams, J. Z.; White, A. F.; Brantley, S. L.

2006-12-01

Few microbiological studies have been conducted within the unsaturated zones between rooting depth and bedrock and thus the relationships between biological activity and mineral nutrient cycling in deep regolith are poorly understood. Here we investigate the weathering of primary minerals containing iron (hornblende and biotite) and phosphorous (apatite) and the role of resident microorganisms in the cycling of these elements in the deep saprolite of the Rio Icacos watershed in Puerto Rico's Luquillo Mountains. In the Rio Icacos watershed, which has one of the fastest documented chemical weathering rates of granitic rock in the world, the quartz diorite bedrock weathers spheroidally, producing a complex interface comprised of partially weathered rock layers called rindlets. This rindlet zone (0.2-2 m thick) is overlain by saprolite (2-8 m) topped by soil (0.5-1 m). With the objective of understanding interactions among mineral weathering, substrate availability and resident microorganisms, we made geochemical and microbiological measurements as a function of depth in 5 m of regolith (soil + saprolite) and examined mineral weathering reactions within a 0.5 m thick spheroidally weathering rindlet zone. We measured total cell densities, culturable aerobic chemoorganotrophs, and microbial DNA yields; and performed biochemical tests for iron-oxidizing bacteria in the regolith samples. Total cell densities, which ranged from 2.5 x 106 to 1.6 x 1010 g-1 regolith, were higher than 108 g-1 at three depths: in the upper 1 m, at 2.1 m, and between 3.7-4.9 m, just above the rindlet zone. Biochemical tests for aerobic iron-oxidizers were also positive at 0.15-0.6 m, at 2.1-2.4 m, and at 4.9 m depths. High proportions of inactive or unculturable cells were indicated throughout the profile by very low percentages of culturable chemoorganotrophs. The observed increases in total and culturable cells and DNA yields at lower depths were correlated with an increase in HCl

Phosphors for solid-state lighting: New systems, deeper understanding

Science.gov (United States)

Denault, Kristin Ashley

We explore the structure-composition-property relationships in phosphor materials using a multitude of structural and optical characterization methods including high resolution synchrotron X-ray and neutron powder diffraction and total scattering, low-temperature heat capacity, temperature- and time-resolved photoluminescence, and density functional theory calculations. We describe the development of several new phosphor compositions and provide an in-depth description of the structural and optical properties. We show structural origins of improved thermal performance of photoluminescence and methods for determining structural rigidity in phosphor hosts that may lead to improved luminescent properties. New white light generation strategies are also explored. We begin by presenting the development of a green-yellow emitting oxyfluoride solid-solution phosphor Sr2Ba(AlO4F)1- x(SiO5)x:Ce3+. An examination of the host lattice, and the local structure around the Ce3+ activator ions points to how chemical substitutions play a crucial role in tuning the optical properties of the phosphor. The emission wavelength can be tuned from green to yellow by tuning the composition, x. Photoluminescent quantum yield is determined to be 70+/-5% for some of the examples in the series with excellent thermal properties. Phosphor-converted LED devices are fabricated using an InGaN LED and are shown to exhibit high color rendering white light. Next, we identify two new phosphor solid-solution systems, (Ba1- xSrx)9 Sc2Si6O24:Ce3+,Li+ and Ba9(Y1-ySc y)2Si6O24:Ce3+. The substitution of Sr for Ba in (Ba1-xSrx ) 9Sc2Si6O24:Ce 3+,Li + results in a decrease of the alkaline earth-oxygen bond distances at all three crystallographic sites, leading to changes in optical properties. The room temperature photoluminescent measurements show the structure has three excitation peaks corresponding to Ce3+ occupying the three independent alkaline earth sites. The emission of (Ba 1- xSrx) 9Sc2Si 6O24:Ce3

Laser discrimination by stimulated emission of a phosphor

Science.gov (United States)

Mathur, V. K.; Chakrabarti, K.

1991-01-01

A method for discriminating sources of UV, near infrared, and far infrared laser radiation was discovered. This technology is based on the use of a single magnesium sulfide phosphor doubly doped with rare earth ions, which is thermally/optically stimulated to generate colors correlatable to the incident laser radiation. The phosphor, after initial charging by visible light, exhibits green stimulated luminescence when exposed to a near infrared source (Nd: YAG laser). On exposure to far infrared sources (CO2 laser) the phosphor emission changes to orange color. A UV laser produces both an orange red as well as green color. A device using this phosphor is useful for detecting the laser and for discriminating between the near infrared, far infrared, and UV lasers. The technology is also capable of infrared laser diode beam profiling since the radiation source leaves an imprint on the phosphor that can be photographed. Continued development of the technology offers potential for discrimination between even smaller bandwidths within the infrared spectrum, a possible aid to communication or wavemixing devices that need to rapidly identify and process optical signals.

Bilateral wilms tumor with TP53-related anaplasia.

Science.gov (United States)

Popov, Sergey D; Vujanic, Gordan M; Sebire, Neil J; Chagtai, Tasnim; Williams, Richard; Vaidya, Sucheta; Pritchard-Jones, Kathy

2013-01-01

Wilms tumor (WT) with diffuse anaplasia has an unfavorable prognosis and is often (>70%) associated with mutations in the TP53 gene. Although most WTs are unilateral, 5-10% are bilateral, and they are almost always present with nephrogenic rests. The latter are considered a precursor of WT. Two cases of bilateral WTs with nephroblastomatosis, in which anaplastic changes were detected over a period of time, were analyzed using clinical, radiological, histopathological, and molecular-genetic data. TP53 was analyzed by direct sequencing of its full coding sequence and intron-exon boundaries in 11 fragments. DNA was extracted from paraffin-embedded or frozen specimens. High-resolution genomic copy number profiling was carried out by UCL Genomics on the Affymetrix Human Mapping 250K Nsp or Genome-Wide Human SNP Array 6.0 platform. Both cases demonstrated a strong association between the appearance of anaplastic clones and TP53 mutations. Synchronous ganglioneuroma was diagnosed in one case. Our cases are unique as they represent a long disease history and demonstrate the difficulties in managing rare cases of bilateral WT with anaplasia. These cases also emphasize the practical importance of modern molecular-genetic techniques and their clinical application. Moreover, they highlight the issue of the adequate sampling needed in order to gather comprehensive, efficient, and sufficient information about genetic events in a single tumor.

Synthesis and photoluminescence properties of Eu{sup 3+}, Sm{sup 3+} and Pr{sup 3+} doped Ca{sub 2}ZnWO{sub 6} phosphors for phosphor converted LED

Energy Technology Data Exchange (ETDEWEB)

Dabre, K.V. [Department of Physics, Arts, Commerce and Science College, Koradi, Nagpur-441111, Maharashtra (India); Dhoble, S.J., E-mail: sjdhoble@rediffmail.com [Department of Physics, R.T.M. Nagpur University, Nagpur-440033, Maharashtra (India)

2014-06-01

In this work, we report on the synthesis and photoluminescence (PL) properties of rare earth (Eu{sup 3+}, Sm{sup 3+} and Pr{sup 3+}) doped double perovskite tungstate Ca{sub 2}ZnWO{sub 6} phosphor. The phosphors were synthesized by two step modified solid state method. Phase purity and formation of phosphor were confirmed by XRD technique. PL spectra of Eu{sup 3+}, Sm{sup 3+} and Pr{sup 3+} doped phosphor show intense emission peaks in red region at 615, 604 and 650 nm respectively, upon the visible excitation of 466 nm (Eu{sup 3+}), 410 nm (Sm{sup 3+}) and 491 nm (Pr{sup 3+}). The CIE coordinates of the phosphors are in the yellow (Sm{sup 3+} doped sample) and orange (Eu{sup 3+} and Pr{sup 3+} doped sample) regions near the edge of color space which confirms their applicability in LEDs. -- Highlights: •Eu{sup 3+}, Sm{sup 3+} and Pr{sup 3+} doped and undoped samples of Ca{sub 2}ZnWO{sub 6} phosphor synthesized by Solid state method. •The phosphors have intense excitation in violet and blue region of visible spectrum. •Phosphors show intense emission peaks in red region. •CIE coordinates of phosphors are lie in yellow (Sm{sup 3+} doped phosphor) and orange (Eu{sup 3+} and Pr{sup 3+} doped phosphor) region near to edge of color space.

TP-model transformation-based-control design frameworks

CERN Document Server

Baranyi, Péter

2016-01-01

This book covers new aspects and frameworks of control, design, and optimization based on the TP model transformation and its various extensions. The author outlines the three main steps of polytopic and LMI based control design: 1) development of the qLPV state-space model, 2) generation of the polytopic model; and 3) application of LMI to derive controller and observer. He goes on to describe why literature has extensively studied LMI design, but has not focused much on the second step, in part because the generation and manipulation of the polytopic form was not tractable in many cases. The author then shows how the TP model transformation facilitates this second step and hence reveals new directions, leading to powerful design procedures and the formulation of new questions. The chapters of this book, and the complex dynamical control tasks which they cover, are organized so as to present and analyze the beneficial aspect of the family of approaches (control, design, and optimization). Additionally, the b...

Evaluation of Energy Consumption in the Mercury Treatment of Phosphor Powder from Spent Fluorescent Lamps Using a Thermal Process

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Yong Choi

2017-11-01

Full Text Available In a pilot-plant-scale thermal mercury treatment of phosphor powder from spent fluorescent lamps, energy consumption was estimated to control mercury content by the consideration of reaction kinetics. Mercury content was analyzed as a function of treatment temperature and time. The initial mercury content of the phosphor powder used in the thermal process was approximately 3500 mg/kg. The target mercury content in the phosphor powder thermal process of the phosphor powder was 5 mg/kg or less at 400 °C or higher because the target mercury content was recommended by Minamata Convention and Basel Convention. During thermal processing, the reaction rate was represented by a first order reaction with the Arrhenius equation. The reaction rate constant increased with temperature from 0.0112 min−1 at 350 °C to 0.0558 min−1 at 600 °C. The frequency factor was 2.51 min−1, and the activation energy was 6509.11 kcal/kg. Reaction rate constants were used to evaluate the treatment time required to reduce mercury content in phosphor powder to be less than 5 mg/kg. The total energy consumption in a pilot-plant-scale thermal process was evaluated to determine the optimal temperature for removing mercury in phosphor powder.

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group.

Science.gov (United States)

Ooms, Ariadne H A G; Gadd, Samantha; Gerhard, Daniela S; Smith, Malcolm A; Guidry Auvil, Jaime M; Meerzaman, Daoud; Chen, Qing-Rong; Hsu, Chih Hao; Yan, Chunhua; Nguyen, Cu; Hu, Ying; Ma, Yussanne; Zong, Zusheng; Mungall, Andrew J; Moore, Richard A; Marra, Marco A; Huff, Vicki; Dome, Jeffrey S; Chi, Yueh-Yun; Tian, Jing; Geller, James I; Mullighan, Charles G; Ma, Jing; Wheeler, David A; Hampton, Oliver A; Walz, Amy L; van den Heuvel-Eibrink, Marry M; de Krijger, Ronald R; Ross, Nicole; Gastier-Foster, Julie M; Perlman, Elizabeth J

2016-11-15

To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs). All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were analyzed for TP53 mutations and copy loss. Integrative genomic analysis was performed on 39 selected DAWTs. Following analysis of a single random sample, 57 DAWTs (48%) demonstrated TP53 mutations, 13 (11%) copy loss without mutation, and 48 (41%) lacked both [defined as TP53-wild-type (wt)]. Patients with stage III/IV TP53-wt DAWTs (but not those with stage I/II disease) had significantly lower relapse and death rates than those with TP53 abnormalities. In-depth analysis of a subset of 39 DAWTs showed seven (18%) to be TP53-wt: These demonstrated gene expression evidence of an active p53 pathway. Retrospective pathology review of TP53-wt DAWT revealed no or very low volume of anaplasia in six of seven tumors. When samples from TP53-wt tumors known to contain anaplasia histologically were available, abnormal p53 protein accumulation was observed by immunohistochemistry. These data support the key role of TP53 loss in the development of anaplasia in WT, and support its significant clinical impact in patients with residual anaplastic tumor following surgery. These data also suggest that most DAWTs will show evidence of TP53 mutation when samples selected for the presence of anaplasia are analyzed. This suggests that modifications of the current criteria to also consider volume of anaplasia and documentation of TP53 aberrations may better reflect the risk of relapse and death and enable optimization of therapeutic stratification. Clin Cancer Res; 22(22); 5582-91. ©2016 AACR. ©2016 American Association for Cancer Research.

Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia

Science.gov (United States)

Olszewska-Pazdrak, Barbara; Carney, Darrell H.

2015-01-01

Revascularization of chronic wounds and ischemic tissue is attenuated by endothelial dysfunction and the inability of angiogenic factors to stimulate angiogenesis. We recently showed that TP508, a nonproteolytic thrombin peptide, increases perfusion and NO-dependent vasodilation in hearts with chronic ischemia and stimulates NO production by endothelial cells. In this study, we investigated systemic in vivo effects of TP508 on VEGF-stimulated angiogenesis in vitro using aortic explants in normoxic and hypoxic conditions. Mice were injected with saline or TP508 and 24h later aortas were removed and cultured to quantify endothelial sprouting. TP508 injection increased endothelial sprouting and potentiated the in vitro response to VEGF. Exposure of control explants to hypoxia inhibited basal and VEGF-stimulated endothelial cell sprouting. This effect of hypoxia was significantly prevented by TP508 injection. Thus, TP508 systemic administration increases responsiveness of aortic endothelial cells to VEGF and diminishes the effect of chronic hypoxia on endothelial cell sprouting. Studies using human endothelial cells in culture suggest that protective effects of TP508 during hypoxia may involve stimulation of endothelial cell NO production. These data suggest potential clinical benefit of using a combination of systemic TP508 and local VEGF as a therapy for revascularization of ischemic tissue. PMID:23594718

Real-time estimation of TP load in a Mississippi Delta Stream using a dynamic data driven application system

Science.gov (United States)

Ying Ouyang; Theodor D. Leininger; Jeff Hatten

2013-01-01

Elevated phosphorus (P) in surface waters can cause eutrophication of aquatic ecosystems and can impair water for drinking, industry, agriculture, and recreation. Currently, no effort has been devoted to estimating real-time variation and load of total P (TP) in surface waters due to the lack of suitable and/or cost-effective wireless sensors. However, when considering...

TP53 status and taxane-platinum versus platinum-based therapy in ovarian cancer patients: A non-randomized retrospective study

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Markowska Janina

2008-01-01

Full Text Available Abstract Background Taxane-platinum therapy (TP has replaced platinum-based therapy (PC or PAC, DNA damaging chemotherapy in the postoperative treatment of ovarian cancer patients; however, it is not always effective. TP53 protein plays a differential role in response to DNA-damaging agents and taxanes. We sought to define profiles of patients who benefit the most from TP and also of those who can be treated with PC. Methods We compared the effectiveness of PC/PAC (n = 253 and TP (n = 199 with respect to tumor TP53 accumulation in ovarian cancer patients with FIGO stage IIB-IV disease; this was a non-randomized retrospective study. Immunohistochemical analysis was performed on 452 archival tumors; univariate and multivariate analysis by the Cox's and logistic regression models was performed in all patients and in subgroups with [TP53(+] and without TP53 accumulation [TP53(-]. Results The advantage of taxane-platinum therapy over platinum-based therapy was seen in the TP53(+, and not in the TP53(- group. In the TP53(+ group taxane-platinum therapy enhanced the probability of complete remission (p = .018, platinum sensitivity (p = .014, platinum highly sensitive response (p = .038 and longer survival (OS, p = .008. Poor tumor differentiation diminished the advantage from taxane-platinum therapy in the TP53(+ group. In the TP53(- group PC/PAC was at least equally efficient as taxane-platinum therapy and it enhanced the chance of platinum highly sensitive response (p = .010. However, in the TP53(- group taxane-platinum therapy possibly diminished the risk of death in patients over 53 yrs (p = .077. Among factors that positively interacted with taxane-platinum therapy in some analyses were endometrioid and clear cell type, FIGO III stage, bulky residual tumor, more advanced age of patient and moderate tumor differentiation. Conclusion Our results suggest that taxane-platinum therapy is particularly justified in patients with TP53(+ tumors or older

Oxycarbonitride phosphors and light emitting devices using the same

Science.gov (United States)

Li, Yuanqiang; Romanelli, Michael Dennis; Tian, Yongchi

2013-10-08

Disclosed herein is a novel family of oxycarbidonitride phosphor compositions and light emitting devices incorporating the same. Within the sextant system of M--Al--Si--O--N--C--Ln and quintuplet system of M--Si--O--N--C--Ln (M=alkaline earth element, Ln=rare earth element), the phosphors are composed of either one single crystalline phase or two crystalline phases with high chemical and thermal stability. In certain embodiments, the disclosed phosphor of silicon oxycarbidonitrides emits green light at wavelength between 530-550 nm. In further embodiments, the disclosed phosphor compositions emit blue-green to yellow light in a wavelength range of 450-650 nm under near-UV and blue light excitation.

Empirical Estimation of Total Nitrogen and Total Phosphorus Concentration of Urban Water Bodies in China Using High Resolution IKONOS Multispectral Imagery

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Jiaming Liu

2015-11-01

Full Text Available Measuring total nitrogen (TN and total phosphorus (TP is important in managing heavy polluted urban waters in China. This study uses high spatial resolution IKONOS imagery with four multispectral bands, which roughly correspond to Landsat/TM bands 1–4, to determine TN and TP in small urban rivers and lakes in China. By using Lake Cihu and the lower reaches of Wen-Rui Tang (WRT River as examples, this paper develops both multiple linear regressions (MLR and artificial neural network (ANN models to estimate TN and TP concentrations from high spatial resolution remote sensing imagery and in situ water samples collected concurrently with overpassing satellite. The measured and estimated values of both MLR and ANN models are in good agreement (R2 > 0.85 and RMSE < 2.50. The empirical equations selected by MLR are more straightforward, whereas the estimated accuracy using ANN model is better (R2 > 0.86 and RMSE < 0.89. Results validate the potential of using high resolution IKONOS multispectral imagery to study the chemical states of small-sized urban water bodies. The spatial distribution maps of TN and TP concentrations generated by the ANN model can inform the decision makers of variations in water quality in Lake Cihu and lower reaches of WRT River. The approaches and equations developed in this study could be applied to other urban water bodies for water quality monitoring.

The quality study of recycled glass phosphor waste for LED

Science.gov (United States)

Tsai, Chun-Chin; Chen, Guan-Hao; Yue, Cheng-Feng; Chen, Cin-Fu; Cheng, Wood-Hi

2017-02-01

To study the feasibility and quality of recycled glass phosphor waste for LED packaging, the experiments were conducted to compare optical characteristics between fresh color conversion layer and that made of recycled waste. The fresh color conversion layer was fabricated through sintering pristine mixture of Y.A.G. powder [yellow phosphor (Y3AlO12 : Ce3+). Those recycled waste glass phosphor re-melted to form Secondary Molten Glass Phosphor (S.M.G.P.). The experiments on such low melting temperature glass results showed that transmission rates of S.M.G.P. are 9% higher than those of first-sintered glass phosphor, corresponding to 1.25% greater average bubble size and 36% more bubble coverage area in S.M.G.P. In the recent years, high power LED modules and laser projectors have been requiring higher thermal stability by using glass phosphor materials for light mixing. Nevertheless, phosphor and related materials are too expensive to expand their markets. It seems a right trend and research goal that recycling such waste of high thermal stability and quality materials could be preferably one of feasible cost-down solutions. This technical approach could bring out brighter future for solid lighting and light source module industries.

Spectral properties of Dy3+ doped ZnAl2O4 phosphor

Science.gov (United States)

Prakash, Ram; Kumar, Sandeep; Mahajan, Rubby; Khajuria, Pooja; Kumar, Vinay; Choudhary, R. J.; Phase, D. M.

2018-05-01

Herein, Dy3+ doped ZnAl2O4 phosphor was synthesized by the solution combustion method. The synthesized phosphor was characterized by X-ray diffraction (XRD), photoluminescence (PL) spectroscopy, UV-Vis spectroscopy and X-ray photoelectron spectroscopy (XPS). The phase purity of the phosphor was confirmed by the XRD studies that showed cubic symmetry of the synthesized phosphor. Under UV excitation (388 nm) the PL emission spectrum of the phosphor shows characteristic transition from the Dy3+ ion. A band gap of 5.2 eV was estimated from the diffused reflectance spectroscopy. The surface properties of the phosphor were studied using the X-ray photoelectron spectroscopy.

Thermal and Electrical Conductivity Measurements of CDA 510 Phosphor Bronze

Science.gov (United States)

Tuttle, James E.; Canavan, Edgar; DiPirro, Michael

2009-01-01

Many cryogenic systems use electrical cables containing phosphor bronze wire. While phosphor bronze's electrical and thermal conductivity values have been published, there is significant variation among different phosphor bronze formulations. The James Webb Space Telescope (JWST) will use several phosphor bronze wire harnesses containing a specific formulation (CDA 510, annealed temper). The heat conducted into the JWST instrument stage is dominated by these harnesses, and approximately half of the harness conductance is due to the phosphor bronze wires. Since the JWST radiators are expected to just keep the instruments at their operating temperature with limited cooling margin, it is important to know the thermal conductivity of the actual alloy being used. We describe an experiment which measured the electrical and thermal conductivity of this material between 4 and 295 Kelvin.

High temperature thermometric phosphors for use in a temperature sensor

Science.gov (United States)

Allison, Stephen W.; Cates, Michael R.; Boatner, Lynn A.; Gillies, George T.

1998-01-01

A high temperature phosphor consists essentially of a material having the general formula LuPO.sub.4 :Dy.sub.(x),Eu.sub.(y), wherein: 0.1 wt %.ltoreq.x.ltoreq.20 wt % and 0.1 wt %.ltoreq.y.ltoreq.20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopent. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions.

Raman Spectra of Luminescent Graphene Oxide (GO-Phosphor Hybrid Nanoscrolls

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Janardhanan. R. Rani

2015-12-01

Full Text Available Graphene oxide (GO-phosphor hybrid nanoscrolls were synthesized using a simple chemical method. The GO-phosphor ratio was varied to find the optimum ratio for enhanced optical characteristics of the hybrid. A scanning electron microscope analysis revealed that synthesized GO scrolls achieved a length of over 20 μm with interior cavities. The GO-phosphor hybrid is extensively analyzed using Raman spectroscopy, suggesting that various Raman combination modes are activated with the appearance of a low-frequency radial breathing-like mode (RBLM of the type observed in carbon nanotubes. All of the synthesized GO-phosphor hybrids exhibit an intense luminescent emission around 540 nm along with a broad emission at approximately 400 nm, with the intensity ratio varying with the GO-phosphor ratio. The photoluminescence emissions were gauged using Commission Internationale d'Eclairage (CIE coordinates and at an optimum ratio. The coordinates shift to the white region of the color spectra. Our study suggests that the GO-phosphor hybrid nanoscrolls are suitable candidates for light-emitting applications.

On the feasibility of infrared phosphors in super-slow particle searches

International Nuclear Information System (INIS)

Hagstrom, R.; Rugari, A.D.

1984-01-01

This chapter proposes that super-slow projectiles will produce ionization signals in media with narrow bandgaps. A specific choice of narrow bandgap phosphors is recommended which would be economically suitable for use as detectors. Topics considered include the possibilities for practical detectors, a description of detectors based on narrow bandgap phosphors, the experimental determination of relevant properties of narrow bandgap phosphors, and the observation of ionizing particles using narrow bandgap phosphors. It is determined that the temperature dependence of the glow of the phosphors is strong enough that a reduction of operating temperature by about 60 C could be sufficient to produce the desired signal to background ratio

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children’s Oncology Group

Science.gov (United States)

Ooms, Ariadne H.A.G.; Gadd, Samantha; Gerhard, Daniela S.; Smith, Malcolm A.; Guidry Auvil, Jaime M.; Meerzaman, Daoud; Chen, Qing-Rong; Hsu, Chih Hao; Yan, Chunhua; Nguyen, Cu; Hu, Ying; Ma, Yussanne; Zong, Zusheng; Mungall, Andrew J.; Moore, Richard A.; Marra, Marco A.; Huff, Vicki; Dome, Jeffrey S.; Chi, Yueh-Yun; Tian, Jing; Geller, James I.; Mullighan, Charles G.; Ma, Jing; Wheeler, David A.; Hampton, Oliver A.; Walz, Amy L.; van den Heuvel-Eibrink, Marry M.; de Krijger, Ronald R.; Ross, Nicole; Gastier-Foster, Julie M.; Perlman, Elizabeth J.

2016-01-01

Purpose To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumor (DAWT). Experimental Design All DAWTs registered on National Wilms Tumor Study-5 (n=118) with available samples were analyzed for TP53 mutations and copy loss. Integrative genomic analysis was performed on 39 selected DAWTs. Results Following analysis of a single random sample, 57 DAWT (48%) demonstrated TP53 mutations, 13(11%) copy loss without mutation, and 48(41%) lacked both (defined as TP53-wildtype (wt)). Patients with Stage III/IV TP53-wt DAWTs (but not those with Stage I/II disease) had significantly lower relapse and death rates than those with TP53 abnormalities. In-depth analysis of a subset of 39 DAWT showed 7(18%) to be TP53-wt: these demonstrated gene expression evidence of an active p53 pathway. Retrospective pathology review of TP53-wt DAWT revealed no or very low volume of anaplasia in 6/7 tumors. When samples from TP53-wt tumors known to contain anaplasia histologically were available, abnormal p53 protein accumulation was observed by immunohistochemistry. Conclusion These data support the key role of TP53 loss in the development of anaplasia in WT, and support its significant clinical impact in patients with residual anaplastic tumor following surgery. These data also suggest that most DAWTs will show evidence of TP53 mutation when samples selected for the presence of anaplasia are analyzed. This suggests that modifications of the current criteria to also consider volume of anaplasia and documentation of TP53 aberrations may better reflect the risk of relapse and death and enable optimization of therapeutic stratification. PMID:27702824

Recuperation of uranium from phosphoric acid

International Nuclear Information System (INIS)

Cordero, G.; Jodra, L.G.; Otero, J.L.; Josa, J.M.

1977-01-01

The Spanish capacity for phosphoric acid production is 500.000 t P 2 O 5 /yr. This acid has an average concentration of 365 g U 3 O 8 / t P 2 O 5 . Therefore about 180 t U 3 O 8 /yr are dissolved. In 1969, the Junta de Energia Nuclear (JEN) developed, in bench scale, a solvent extraction process to recover the uranium from the phosphoric acid. The solvent used was a synergistic mixture of D2EHPA and TOPO. The results were very promising with good recovery and very high quality for the uranium concentrate. Later, the J.E.N. continued the studies in a pilot plant scale. For this purpose, was built an experimental facility in Huelva; it can treat about 7 cu. m/day of brown acid. Fosforico Espanol, S.A. (FESA) collaborated in the studies and agreed to setting up these installations in their factory. They also provided fresh phosphoric acid for the tests. In this pilot plant we studied the following stages: a) Clarification and conditioning of the phosphoric acid; b) Uranium extraction followed by stripping in a reducing medium; c) Purification by extraction and washing; d) Obtention of the concentrate by stripping with ammonia and CO 2 gas, followed by crystallization of the ammonium uranyl tricarbonate (AUT); and e) Calcination of the concentrate to decompose the AUT to uranium oxides. The results confirmed the laboratory test data. Recuperation levels were between 85 and 90%. The AUT calcined at 550 0 C. gave a product with 96-98% U 3 O 8 . In view of the pilot plant results we have prepared a black book for an industrial plant to treat about 3700 cu. m/day of phosphoric acid. At the present time the financial aspects of this installation are being studied [es

Process for recovering yttrium and lanthanides from wet-process phosphoric acid

Energy Technology Data Exchange (ETDEWEB)

Janssen, J.A.; Weterings, C.A.

1983-06-28

Process for recovering yttrium and lanthanides from wet-process phosphoric acid by adding a flocculant to the phosphoric acid, separating out the resultant precipitate and then recovering yttrium and lanthanides from the precipitate. Uranium is recovered from the remaining phosphoric acid.

CaSO4:DY,Mn: A new and highly sensitive thermoluminescence phosphor for versatile dosimetry

Science.gov (United States)

Bahl, Shaila; Lochab, S. P.; Kumar, Pratik

2016-02-01

With the advent of newer techniques for dose reduction coupled with the development of more sensitive detectors, the radiation doses in radiological medical investigation are decreasing. Nevertheless, keeping the tenet in mind that all radiation doses could entail risk, there is a need to develop more sensitive dosimeters capable of measuring low doses. This paper gives the account of the development of a new and sensitive phosphor CaSO4:Dy,Mn and its characterization. The standard production procedure based on the recrystallization method was used to prepare CaSO4:Dy,Mn. The Thermoluminescence (TL) studies were carried out by exposing it with gamma radiation (Cs-137) from 10 μGy to 100 Gy. The theoretical studies to determine the number of peaks and kinetic parameters related to the TL glow peaks in CaSO4:Dy,Mn was performed using the Computerized Glow Curve Deconvolution (CGCD) method. Experiments were performed to determine optimum concentration of the dopants Dysprosium (Dy) and Mangnese (Mn) in the host CaSO4 so that maximum sensitivity of the phosphor may be achieved. The optimum dopant concentration turned out to be 0.1 mol%. As there were two dopants Dy and Mn their relative ratio were varied in steps of 0.025 keeping the concentration of total dopant (Dy and Mn) 0.1 mol% always. The maximum TL intensity was seen in the CaSO4:Dy(0.025),Mn(0.075) combination. The TL sensitivity of this phosphor was found to be about 2 and 1.8 times higher than that of popular phosphor CaSO4:Dy and LiF:Mg,Cu,P (TLD-700H) respectively. This new phosphor CaSO4:Dy,Mn showed fading of 11% which is similar to that of the standard phosphor CaSO4:Dy. The paper concludes that the new, highly sensitive TL phosphor CaSO4:Dy,Mn has shown higher sensitivity and hence the potential to replace commonly used CaSO4:Dy.

Development of BaSO4:Eu thermoluminescence phosphor

International Nuclear Information System (INIS)

Madhusoodanan, U.; Jose, M.T.; Lakshmanan, A.R.

1999-01-01

A highly sensitive thermoluminescence (TL) phosphor based on BaSO 4 :Eu was developed following the coprecipitation technique and firing in argon atmosphere at 1123 K. Photoluminescence studies confirm that firing in argon atmosphere instead of air increased the incorporation of Eu ions in 2+ valence state. At low γ-ray doses, its TL sensitivity is nearly 2 to 3 times higher than that of CaSO 4 :Dy phosphor. The other salient features of this BaSO 4 :Eu TL phosphor are a constant glow curve shape and a nearly linear γ-ray dose response

Counter current extraction of phosphoric acid: Food grade acid production

International Nuclear Information System (INIS)

Shlewit, H.; AlIbrahim, M.

2009-01-01

Extraction, scrubbing and stripping of phosphoric acid from the Syrian wet-phosphoric acid was carried out using Micro-pilot plant of mixer settler type of 8 l/h capacity. Tributyl phosphate (TBP)/di-isopropyl ether (DIPE) in kerosene was used as extractant. Extraction and stripping equilibrium curves were evaluated. The number of extraction and stripping stages to achieve the convenient and feasible yield was determined. Detailed flow sheet was suggested for the proposed continuous process. Data obtained include useful information for the design of phosphoric acid extraction plant. The produced phosphoric acid was characterized using different analytical techniques. (author)

Point defect engineering strategies to retard phosphorous diffusion in germanium

KAUST Repository

Tahini, H. A.; Chroneos, Alexander I.; Grimes, Robin W.; Schwingenschlö gl, Udo; Bracht, Hartmut A.

2013-01-01

The diffusion of phosphorous in germanium is very fast, requiring point defect engineering strategies to retard it in support of technological application. Density functional theory corroborated with hybrid density functional calculations are used to investigate the influence of the isovalent codopants tin and hafnium in the migration of phosphorous via the vacancy-mediated diffusion process. The migration energy barriers for phosphorous are increased significantly in the presence of oversized isovalent codopants. Therefore, it is proposed that tin and in particular hafnium codoping are efficient point defect engineering strategies to retard phosphorous migration. © the Owner Societies 2013.

TP53 codon 72 polymorphism in pigmentary phenotypes

Indian Academy of Sciences (India)

2012-01-20

Jan 20, 2012 ... pigmentation by acting as a transcription factor for other genes that are ... skin phototype I-II, burns after exposure to UVR and the development of .... morphisms of TP53 codon 72 with breast carcinoma risk: evidence from ...

Phosphor Scanner For Imaging X-Ray Diffraction

Science.gov (United States)

Carter, Daniel C.; Hecht, Diana L.; Witherow, William K.

1992-01-01

Improved optoelectronic scanning apparatus generates digitized image of x-ray image recorded in phosphor. Scanning fiber-optic probe supplies laser light stimulating luminescence in areas of phosphor exposed to x rays. Luminescence passes through probe and fiber to integrating sphere and photomultiplier. Sensitivity and resolution exceed previously available scanners. Intended for use in x-ray crystallography, medical radiography, and molecular biology.

Synthesis and luminescence properties of Eu"2"+ doped CaSO_4 phosphor

International Nuclear Information System (INIS)

Aghalte, G.A.; Dhoble, S.J.; Pawar, N.R.

2016-01-01

Eu"2"+ doped CaSO_4 Phosphor were synthesized by precipitation method. PL analysis of Eu"2"+ activated CaSO_4 phosphor exhibited characteristic emission properties; CaSO_4:Eu Phosphor has received considerable attention because of its high sensitivity to X-ray and λ ray irradiation. CaSO_4:Eu phosphor powder was successfully synthesized by the wet chemical co-precipitation method. The structure morphology and luminescent properties of the phosphor were characterized by X-ray diffraction, scanning electron microscopy and photoluminescence spectroscopy

Purification of di-nonyl phenyl phosphoric acid (DNPPA) for synergistic extraction of uranium from strong phosphoric acid

International Nuclear Information System (INIS)

Singh, D.K.; Vijayalakshmi, R.; Singh, H.; Sharma, J.N.; Ruhela, R.

2009-01-01

Di-nonyl phenyl phosphoric acid (DNPPA) obtained from various synthesis methods is always associated with impurities such as mono-nonyl phenyl phosphoric acid and nonyl phenol which need to be separated for its effective use in the extraction of uranium from strong phosphoric acid. Two methods of purification namely liquid-solid separation method using neodymium salt and liquid-liquid separation method using methylene glycol have been described. In the liquid solid separation method the purity of DNPPA obtained was about 95% with less than 1.0% monoester, however it heavily suffers in the recovery aspect which is of the order of 50-60%. The methylene glycol treatment method, results in high purity and recovery of the product. Purity obtained was about 95.0% diester and less than 0.5% monoester and recovery was more than 90%. Analysis of DNPPA was done by potentiometric titration method using autotitrator. (author)

TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia.

Directory of Open Access Journals (Sweden)

Mariana Maschietto

Full Text Available The presence of diffuse anaplasia in Wilms tumours (DAWT is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers additional prognostic information.We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. The majority of cases were profiled by copy number (n = 32 and gene expression (n = 36 arrays. TP53 mutational status was correlated with patient event-free and overall survival, genomic copy number instability and gene expression profiling.From the 40 cases, 22 (55% had TP53 mutations (2 detected only after deep-sequencing, 20 of which also had 17p loss (91%; 18 (45% cases had no detectable mutation but three had 17p loss. Tumours with TP53 mutations and/or 17p loss (n = 25 had an increased risk of recurrence as a first event (p = 0.03, hazard ratio (HR, 3.89; 95% confidence interval (CI, 1.26-16.0 and death (p = 0.04, HR, 4.95; 95% CI, 1.36-31.7 compared to tumours lacking TP53 abnormalities. DAWT carrying TP53 mutations showed increased copy number alterations compared to those with wild-type, suggesting a more unstable genome (p = 0.03. These tumours showed deregulation of genes associated with cell cycle and DNA repair biological processes.This study provides evidence that TP53 mutational analysis improves risk stratification in DAWT. This requires validation in an independent cohort before clinical use as a biomarker.

TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia.

Science.gov (United States)

Maschietto, Mariana; Williams, Richard D; Chagtai, Tasnim; Popov, Sergey D; Sebire, Neil J; Vujanic, Gordan; Perlman, Elizabeth; Anderson, James R; Grundy, Paul; Dome, Jeffrey S; Pritchard-Jones, Kathy

2014-01-01

The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers additional prognostic information. We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. The majority of cases were profiled by copy number (n = 32) and gene expression (n = 36) arrays. TP53 mutational status was correlated with patient event-free and overall survival, genomic copy number instability and gene expression profiling. From the 40 cases, 22 (55%) had TP53 mutations (2 detected only after deep-sequencing), 20 of which also had 17p loss (91%); 18 (45%) cases had no detectable mutation but three had 17p loss. Tumours with TP53 mutations and/or 17p loss (n = 25) had an increased risk of recurrence as a first event (p = 0.03, hazard ratio (HR), 3.89; 95% confidence interval (CI), 1.26-16.0) and death (p = 0.04, HR, 4.95; 95% CI, 1.36-31.7) compared to tumours lacking TP53 abnormalities. DAWT carrying TP53 mutations showed increased copy number alterations compared to those with wild-type, suggesting a more unstable genome (p = 0.03). These tumours showed deregulation of genes associated with cell cycle and DNA repair biological processes. This study provides evidence that TP53 mutational analysis improves risk stratification in DAWT. This requires validation in an independent cohort before clinical use as a biomarker.

Self-adaptive phosphor coating technology for wafer-level scale chip packaging

International Nuclear Information System (INIS)

Zhou Linsong; Rao Haibo; Wang Wei; Wan Xianlong; Liao Junyuan; Wang Xuemei; Zhou Da; Lei Qiaolin

2013-01-01

A new self-adaptive phosphor coating technology has been successfully developed, which adopted a slurry method combined with a self-exposure process. A phosphor suspension in the water-soluble photoresist was applied and exposed to LED blue light itself and developed to form a conformal phosphor coating with self-adaptability to the angular distribution of intensity of blue light and better-performing spatial color uniformity. The self-adaptive phosphor coating technology had been successfully adopted in the wafer surface to realize a wafer-level scale phosphor conformal coating. The first-stage experiments show satisfying results and give an adequate demonstration of the flexibility of self-adaptive coating technology on application of WLSCP. (semiconductor devices)

Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition.

Science.gov (United States)

Xie, Xiaolei; Le, Li; Fan, Yanxin; Lv, Lin; Zhang, Junjie

2012-07-01

Mitoribosome in mammalian cells is responsible for synthesis of 13 mtDNA-encoded proteins, which are integral parts of four mitochondrial respiratory chain complexes (I, III, IV and V). ERAL1 is a nuclear-encoded GTPase important for the formation of the 28S small mitoribosomal subunit. Here, we demonstrate that knockdown of ERAL1 by RNA interference inhibits mitochondrial protein synthesis and promotes reactive oxygen species (ROS) generation, leading to autophagic vacuolization in HeLa cells. Cells that lack ERAL1 expression showed a significant conversion of LC3-I to LC3-II and an enhanced accumulation of autophagic vacuoles carrying the LC3 marker, all of which were blocked by the autophagy inhibitor 3-MA as well as by the ROS scavenger NAC. Inhibition of mitochondrial protein synthesis either by ERAL1 siRNA or chloramphenicol (CAP), a specific inhibitor of mitoribosomes, induced autophagy in HTC-116 TP53 (+/+) cells, but not in HTC-116 TP53 (-/-) cells, indicating that tumor protein 53 (TP53) is essential for the autophagy induction. The ROS elevation resulting from mitochondrial protein synthesis inhibition induced TP53 expression at transcriptional levels by enhancing TP53 promoter activity, and increased TP53 protein stability by suppressing TP53 ubiquitination through MAPK14/p38 MAPK-mediated TP53 phosphorylation. Upregulation of TP53 and its downstream target gene DRAM1, but not CDKN1A/p21, was required for the autophagy induction in ERAL1 siRNA or CAP-treated cells. Altogether, these data indicate that autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition.

IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients

Directory of Open Access Journals (Sweden)

Gergana Stancheva

2014-01-01

Full Text Available Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1 and 2 (IDH2 have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall survival 106 glioblastoma patients were analysed. IDH1 mutations were detected in 13 and IDH2 mutation in one patient. Two homozygous samples with R132H mutation in IDH1 gene and a novel aberration K129R in IDH2 gene were found. Sixty-four percent of IDH1/IDH2 mutated tumours harboured also a mutation in TP53 gene. Genetic aberrations in TP53 were present in 37 patients. Statistical analysis of the impact of the studied factors on the overall survival showed that the mutations in IDH1/IDH2, but not the ones in TP53, were associated with longer survival. Also, the impact of age on prognosis was confirmed. This is the first comprehensive study on glioblastomas in Bulgaria. Our results suggest that IDH1/IDH2 but not TP53 mutations together with other prognostic factors such as age might be applied in clinical practice for prediction of outcome in patients with glioblastomas.

Low lag luminescent phosphors

International Nuclear Information System (INIS)

1976-01-01

The addition of potassium or rubidium salts to europium-activated fluorohalide phosphors produces X-ray screens with low lag, even at very low europium concentrations. The chemical preparation and afterglow test results are described

Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy.

Science.gov (United States)

Kashofer, Karl; Regauer, Sigrid

2017-08-01

This study evaluates the frequency and type of TP53 gene mutations and HPV status in 72 consecutively diagnosed primary invasive vulvar squamous cell carcinomas (SCC) during the past 5years. DNA of formalin-fixed and paraffin embedded tumour tissue was analysed for 32 HPV subtypes and the full coding sequence of the TP53 gene, and correlated with results of p53 immunohistochemistry. 13/72 (18%) cancers were HPV-induced squamous cell carcinomas, of which 1/13 (8%) carcinoma harboured a somatic TP53 mutation. Among the 59/72 (82%) HPV-negative cancers, 59/72 (82%) SCC were HPV-negative with wild-type gene in 14/59 (24%) SCC and somatic TP53 mutations in 45/59 (76%) SCC. 28/45 (62%) SCC carried one (n=20) or two (n=8) missense mutations. 11/45 (24%) carcinomas showed a single disruptive mutation (3× frame shift, 7× stop codon, 1× deletion), 3/45 SCC a splice site mutation. 3/45 (7%) carcinomas had 2 or 3 different mutations. 18 different "hot spot" mutations were observed in 22/45 cancers (49%; 5× R273, 3× R282; 2× each Y220, R278, R248). Immunohistochemical p53 over expression was identified in most SCC with missense mutations, but not in SCC with disruptive TP53 mutations or TP53 wild-type. 14/45 (31%) patients with TP53 mutated SCC died of disease within 12months (range 2-24months) versus 0/13 patients with HPV-induced carcinomas and 0/14 patients with HPV-negative, TP53 wild-type carcinomas. 80% of primary invasive vulvar SCC were HPV-negative carcinomas with a high frequency of disruptive mutations and "hot spot" TP53 gene mutations, which have been linked to chemo- and radioresistance. The death rate of patients with p53 mutated vulvar cancers was 31%. Immunohistochemical p53 over expression could not reliably identify SCC with TP53 gene mutation. Pharmacological therapies targeting mutant p53 will be promising strategies for personalized therapy in patients with TP53 mutated vulvar cancers. Copyright © 2017. Published by Elsevier Inc.

Thermoluminescence of calcium-based phosphors

International Nuclear Information System (INIS)

Sunta, C.M.

1985-01-01

The paper reviews the thermoluminescence (TL) properties of calcium fluoride, calcium sulphate and calcium carbonate phosphors. In the case of the calcium fluoride mineral phosphor the main emitter of TL is the cerium impurity. Based on the TL emission spectra, two types of Ce 3+ centres can be easily distinguished; those associated with O 2- compensating ion and those which have either no local compensators or are associated with F - interstitial ions at the adjacent vacant body centre position. The spectra undergo remarkable changes at high doses. Such changes are associated with the probabilities of charge trapping at different types of traps and also with the probabilities of recombination at different types of luminescent centres. Some of the traps and recombination centres are spatially associated while others are distributed randomly. In calcium carbonate mineral, Mn 2+ is invariably the emitting impurity. Mn 2+ can be used as an efficient dopant for TL emission in all the three calcium based TL phosphors. A co-dopant like Ce 3+ intensifies the luminescence yield from Mn 2+ . Models of different types of electron and hole trapping centres are given. (author)

Photoluminescence analysis of Ce3+:Zn2SiO4 & Li++ Ce3+:Zn2SiO4: phosphors by a sol-gel method

Science.gov (United States)

Babu, B. Chandra; Vandana, C. Sai; Guravamma, J.; Rudramadevi, B. Hemalatha; Buddhudu, S.

2015-06-01

Here, we report on the development and photoluminescence analysis of Zn2SiO4, Ce3+:Zn2SiO4 & Li+ + Ce3+: Zn2SiO4 novel powder phosphors prepared by a sol-gel technique. The total amount of Ce3+ ions was kept constant in this experiment at 0.05 mol% total doping. The excitation and emission spectra of undoped (Zn2SiO4) and Ce3+ doped Zn2SiO4 and 0.05 mol% Li+ co-doped samples have been investigated. Cerium doped Zn2SiO4 powder phosphors had broad blue emission corresponding to the 2D3/2→2FJ transition at 443nm. Stable green-yellow-red emission has been observed from Zn2SiO4 host matrix and also we have been observed the enhanced luminescence of Li+ co-doped Zn2SiO4:Ce3+. Excitation and emission spectra of these blue luminescent phosphors have been analyzed in evaluating their potential as luminescent screen coating phosphors.

Use of the integration elements encoded by the temperate lactococcal bacteriophage TP901-1

DEFF Research Database (Denmark)

Brøndsted, Lone; Hammer, Karin

1999-01-01

Previously we showed that only one phage-expressed protein (Orf1), a 425-bp region upstream of the orf1 gene (presumably encoding a promoter), and the attP region are necessary and also sufficient for integration of the bacteriophage TP901-1 genome into the chromosome of Lactococcus lactis subsp......P region seem to be necessary for site-specific integration of the temperate bacteriophage TP901-1. By use of the integrative elements (attP and orf1) expressed by the temperate lactococcal bacteriophage TP901-1, a system for obtaining stable chromosomal single-copy transcriptional fusions in L. lactis...

Germline TP53 mutations and single nucleotide polymorphisms in children Mutaciones y polimorfismos de un único nucleótido del gen TP53 en línea germinal en niños

Directory of Open Access Journals (Sweden)

Pamela Valva

2009-02-01

Full Text Available Mutations in the gene TP53, which codifies the tumor suppressor protein p53, are found in about 50% of tumors. These mutations can occur not only at somatic level, but also in germline. Pediatric cancer patients, mostly with additional family history of malignancy, should be considered as potential TP53 germline mutation carriers. Germline TP53 mutations and polymorphisms have been widely studied to determine their relation with different tumors' pathogenesis. Our aim was to analyze the occurrence frequency of germline TP53 mutations and polymorphisms and to relate these to tumor development in a pediatric series. Peripheral blood mononuclear cell samples from 26 children with solid tumors [PST] and 21 pediatric healthy donors [HD] were analyzed for germline mutations and polymorphisms in TP53 gene spanning from exon 5 to 8 including introns 5 and 7. These PCR amplified fragments were sequenced to determine variations. A heterozygous mutation at codon 245 was found in 1/26 PST and 0/21 HD. Comparative polymorphisms distribution, at position 14181 and 14201(intron 7, between HD and PST revealed a trend of association (p= 0.07 with cancer risk. HD group disclosed a similar polymorphism distribution as published data for Caucasian and Central/South American populations. This is the first study about TP53 variant frequency and distribution in healthy individuals and cancer patients in Argentina.El gen que codifica para la proteína supresora de tumor p53 (TP53 se encuentra mutado en aproximadamente el 50% de los tumores. Estas mutaciones pueden presentarse como somáticas o en línea germinal. Los niños con tumores, sobre todo aquellos con historia familiar de enfermedad oncológica, deben considerarse potenciales portadores de mutaciones en línea germinal. Las mutaciones de TP53 y los polimorfismos son estudiados para determinar su relación con la patogénesis de diferentes tumores. El objetivo del trabajo fue analizar la frecuencia de

Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship.

Science.gov (United States)

Ardighieri, Laura; Mori, Luigi; Conzadori, Sara; Bugatti, Mattia; Falchetti, Marcella; Donzelli, Carla Maria; Ravaggi, Antonella; Odicino, Franco E; Facchetti, Fabio

2016-07-01

Pelvic carcinosarcomas (PCSs) are rare aggressive biphasic tumors that localize in the ovary, fallopian tube, or peritoneum and present frequently as bilateral disease. We undertook a morphological, p53 immunohistochemical and TP53 gene mutational analysis study in a single institution cohort of 16 PCSs in order to investigate the nature of bilateral tumors and to shed light on their origin and pathogenesis. Of the 16 patients, 10 presented with bilateral disease, 6 with a carcinosarcoma in both adnexa, and the remaining cases with a carcinosarcoma in one adnexum and a carcinoma in the opposite. The carcinoma component showed high-grade serous features in 13/16 of cases (81 %). In 10 patients (63 %), a serous tubal intraepithelial carcinoma (STIC) was found, in one case bilateral, making a total of 11 STICs. STIC was found only in cases with a carcinoma component with high-grade serous features. All 10 bilateral tumors and all 11 PCS-associated STICs showed a similar p53 immunostaining pattern. At mutation analysis of the TP53 gene, all five bilateral PCS contained an identical mutation in both localizations. Furthermore, a TP53 mutation was found in 8 of 10 STICs, with an identical mutation in the associated PCS. The finding of similar p53 immunostaining in all bilateral cases and identical TP53 mutations in most PCS-associated STIC provides evidence for a clonal relation between these neoplastic lesions, supporting a metastatic nature of bilateral PCS and suggesting that they have an extraovarian origin in a STIC.

Association of TP53 and MDM2 polymorphisms with survival in bladder cancer patients treated with chemoradiotherapy

International Nuclear Information System (INIS)

Shinohara, Asano; Sakano, Shigeru; Hinoda, Yuji; Nishijima, Jun; Kawai, Yoshihisa; Misumi, Taku; Nagao, Kazuhiro; Hara, Takahiko; Matsuyama, Hideyasu

2009-01-01

Platinum-based chemoradiotherapy (CRT) as bladder conservation therapy has shown promising results for muscle-invasive bladder cancer. However, CRT might diminish survival as a result of the delay in cystectomy for some patients with non-responding bladder tumors. Because the p53 tumor suppression pathway, including its MDM2 counterpart, is important in chemotherapy- and radiotherapy-associated effects, functional polymorphisms in the TP53 and MDM2 genes could influence the response to treatment and the prognosis following CRT. We investigated associations between two such polymorphisms, and p53 overexpression, and response or survival in bladder cancer patients treated with CRT. The study group comprised 96 patients who underwent CRT for transitional cell carcinoma of the bladder. Single nucleotide polymorphisms (SNPs) in TP53 (codon 72, arginine>proline) and MDM2 (SNP3O9, T>G) were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP), and nuclear expression levels of p53 were examined using immunohistochemistry. None of the genotypes or p53 overexpression was significantly associated with response to CRT. However, patients with MDM2 T/G+G/G genotypes had improved cancer-specific survival rates after CRT (P=0.009). In multivariate analysis, the MDM2 T/G+G/G genotypes, and more than two of total variant alleles in TP53 and MDM2, were independently associated with improved cancer-specific survival (P=0.031 and P=0.015, respectively). In addition, MDM2 genotypes were significantly associated with cystectomy-free survival (P=0.030). These results suggest that the TP53 and MDM2 genotypes might be useful prognostic factors following CRT in bladder cancer, helping patient selection for bladder conservation therapy. (author)

Calibração de modelo para a simulação de vazão e de fósforo total nas sub-bacias dos Rios Conrado e Pinheiro - Pato Branco (PR Model calibration for flow rate and total phosphorous export simulations in the watersheds of the rivers conrado and Pinheiro, Pato Branco (PR

Directory of Open Access Journals (Sweden)

Valmir Baltokoski

2010-02-01

ção do nutriente ao longo do ano.Hydrological models developed to predict the impacts of non-point source pollution and land use and occupation on water quality have been extremely useful in the study of agricultural systems. For this purpose, the objective of this study was to evaluate the sensitivity of the model SWAT 2005 (Soil and Water Assessment Tool to simulate the flow rate and total phosphorous flow mass. The research was conducted in two contiguous watersheds of the Conrado and Pinheiro rivers, affluents to the Pato Branco river, in Pato Branco and Mariopolis counties, state of Paraná. Climatological data of the period 1979-2006 and observation data of flow rate and total phosphorous export of the years 2004 and 2005 from two weather stations (in the lower part of the main water course of the Conrado and Pinheiro rivers were used. The model requires input data in spatial format of land use and soil data, associated to a digital elevation model (DEM. The AvSWAT-X interface was used with ArcView 3.3® and its extension Spatial Analyst 2.0®, for data input and manipulation. Monthly and yearly averages of flow rate and total phosphorous export were compared to the observed values. The Nash-Sutcliffe Coefficient (COE was used to evaluate the modeling efficiency. The modeling was improved by including the sensitivity analysis, autocalibration tool and manual adjustment, showing that, with regular sampling frequency, the SWAT 2005 model simulated the flow rate and total phosphorous export satisfactorily. In the case of irregular sampling frequency and limited dataset, however, autocalibration and sensitivity analysis were not efficient to simulate the flow rate and total phosphorous export results. Besides, different sensitivity levels were observed for the two stations, reflecting inequalities of the Hydrologic Response Units. The simulated monthly distribution of phosphorous export showed the heterogeneity of P application over the course of the year.

Comparison between mixed and spatially separated remote phosphor fabricated via a screen-printing process

Science.gov (United States)

Kim, Byung-Ho; Hwang, Jonghee; Lee, Young Jin; Kim, Jin-Ho; Jeon, Dae-Woo; Lee, Mi Jai

2016-08-01

We developed a fabrication method for remote phosphor by a screen-printing process, using green phosphor, red phosphor, and thermally stable glass frit. The glass frit was introduced for long-term stability. The optical properties of the remote phosphor were observed via an integrating sphere; the photoluminescence spectrum dramatically changed on incorporating a minor amount of the red phosphor. These unique optical properties were elucidated using four factors: phosphor ratio, scattering induced by packing density, light intensity per unit volume, and reabsorption. The thermal stability of the remote phosphor was investigated at 500°C, demonstrating its outstanding thermal properties.

Luminescent properties of phosphor converted LED using an orange-emitting Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} phosphor

Energy Technology Data Exchange (ETDEWEB)

Song, Hee Jo; Yim, Dong Kyun [Department of Materials Science and Engineering, College of Engineering, Seoul National University, Daehak-dong, Gwanak-gu, Seoul 151-744 (Korea, Republic of); Cho, In-Sun [Department of Mechanical Engineering, Stanford University, CA 94305 (United States); Roh, Hee-Suk; Kim, Ju Seong [Department of Materials Science and Engineering, College of Engineering, Seoul National University, Daehak-dong, Gwanak-gu, Seoul 151-744 (Korea, Republic of); Kim, Dong-Wan, E-mail: dwkim@ajou.ac.kr [Department of Materials Science and Engineering, Ajou University, Woncheon-dong, San 5, Yeongtong-gu, Suwon 443-749 (Korea, Republic of); Hong, Kug Sun, E-mail: kshongss@plaza.snu.ac.kr [Department of Materials Science and Engineering, College of Engineering, Seoul National University, Daehak-dong, Gwanak-gu, Seoul 151-744 (Korea, Republic of)

2012-12-15

Graphical abstract: Display Omitted Highlights: ► Phase-pure Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} powders were synthesized by a solid state reaction process. ► The optimum emission intensity was observed at the Eu{sup 2+} ion concentration of 0.006. ► The dipole–dipole interaction was the major concentration quenching mechanism. ► The pc-LED coated with Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} had higher CRI than commercial red phosphor. -- Abstract: A series of orange-emitting Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} phosphors were synthesized by a conventional solid-state reaction method. The as-prepared phosphors were characterized by X-ray powder diffraction (XRD), fluorescence spectroscopy, and spectroradiometry. XRD showed that all prepared samples exhibited a monoclinic Rb{sub 2}CaP{sub 2}O{sub 7} phase. Fluorescence spectroscopy showed that the photoluminescence efficiency of Rb{sub 2}Ca{sub 1−x}P{sub 2}O{sub 7}:Eu{sub x}{sup 2+} phosphors increased with increasing Eu{sup 2+} concentration until x = 0.006, then decreased at higher concentrations, due to a concentration quenching effect. The thermal activation energy was also measured to be 0.40 eV. Furthermore, a phosphor-converted LED (pc-LED) coated with Rb{sub 2}Ca{sub 0.994}P{sub 2}O{sub 7}:Eu{sub 0.006}{sup 2+} was fabricated, which exhibited bright orange emission under a forward bias, from 200 to 300 mA. The color rendering index (CRI) of pc-LED coated with Rb{sub 2}Ca{sub 0.994}P{sub 2}O{sub 7}:Eu{sub 0.006}{sup 2+} was higher than the CRI of pc-LED coated with commercial red phosphor, due to the broad emission band of Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} phosphor. In applying with three-band pc-LEDs, moreover, white pc-LED using Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} phosphor had a higher CRI, than using commercial phosphor. These results indicated that Rb{sub 2}CaP{sub 2}O{sub 7}:Eu{sup 2+} phosphor could be a good candidate for a near-UV based w-LED.

Recovering of uranium from phosphoric acid produced by the wet process

International Nuclear Information System (INIS)

Barreiro, A.J.; Lyon, W.L.; Holleman, R.A.; Randell, C.C.

1977-01-01

Process for recovering uranium as from an aqueous solution of phosphoric acid arising from a wet process, with a scrubbing agent essentially composed of a hydrocarbon whose boiling point is situated between 150 0 C and 300 0 C, which reacts with the contaminents formed in the sludge in the phosphoric acid, in an efficient enough quantity to wash the contamination products forming the phosphoric acid sludge, give a sludge phase and a purified phosphoric acid phase, after which the sludge phase is extracted [fr

Synthesis of novel Dy3+ activated phosphate phosphors for NUV excited LED

International Nuclear Information System (INIS)

Shinde, K.N.; Dhoble, S.J.; Kumar, Animesh

2011-01-01

The new trivalent dysprosium activated X 6 AlP 5 O 20 (where X=Sr, Ba, Ca and Mg) phosphors were prepared by the combustion method. The prepared phosphors are characterized by XRD, photoluminescence and SEM techniques. Excited by 350 nm near-ultraviolet (NUV) light, the phosphors show an efficient blue and yellow band emissions, which originates from the 4 F 9/2 → 6 H 15/2 and 4 F 9/2 → 6 H 13/2 transitions of Dy 3+ ion, respectively. The excitation spectra of the phosphors are broadband extending from 340 to 400 nm, which are characteristics of NUV excited LED. The effect of the Dy 3+ concentration on the luminescence properties of X 6 AlP 5 O 20 :Dy 3+ (where X=Sr, Ba, Ca and Mg) phosphors is studied. Ca 6 AlP 5 O 20 phosphors show strong PL emission intensity around 25 times more as compared to Ba 6 AlP 5 O 20 , Sr 6 AlP 5 O 20 and Mg 6 AlP 5 O 20 phosphors. The investigated prepared phosphors are suitable for a NUV excited LED. - Research highlights: → Novel Dy 3+ activated X 6 AlP 5 O 20 (where X=Sr,Ba,Ca and Mg) phosphors were prepared by combustion method which is very low cost and time saving synthesis method. → The excitation spectra of the phosphors are broad band extending from 340 nm to 400 nm, which is characteristics of NUV excited LED. → PL emission spectra show two emissions (485 and 573 nm) and X 6 AlP 5 O 20 :Dy 3+ 0.5 mol% (where X=Sr,Ba,Ca and Mg) phosphors shows strongest PL emission intensity. → SEM analysis indicates that phosphor particles have irregular shape, porous morphology and less than 3-4 μm in size, which is suitable for the solid state lighting (coating purpose).

Blue emitting KSCN:xCe phosphor for solid state lighting

Energy Technology Data Exchange (ETDEWEB)

Chikte, Devayani, E-mail: devi.awade@gmail.com [G.N. Khalsa College, Matunga, Mumbai 400019 (India); Omanwar, S.K. [Department of Physics, S.G.B. Amravati University, Amravati (India); Moharil, S.V. [Department of Physics, R.T.M. Nagpur University, Nagpur 440010 (India)

2014-01-15

The intense blue emitting phosphor KSCN:xCe (x=0.005, 0.01, 0.02, 0.04) is synthesized by a simple, time saving, economical method of re-crystallization through aqueous solution at 353 K. Photoluminescence measurements showed that the said phosphor exhibits emission with good intensity peaking at 450 nm corresponding to d→f transitions of Ce{sup 3+} ion. The excitation spectra monitored at 450 nm shows small peak at 282 nm and broad intense excitation band peaking at 350 nm. The latter lies in near ultraviolet (350–410 nm) emission of UV LED. The phosphor KSCN:0.02Ce{sup 3+} shows CIE 1931 color coordinates as (0.1484, 0.0602) whereas the commercial blue phosphor BAM:Eu{sup 2+} shows the color co-ordinates as (0.1417, 0.1072), respectively, indicating better color purity for KSCN: 0.02Ce{sup 3+} compared to the BAM:Eu{sup 2+} phosphor. The color coordinates of KSCN: 0.02Ce{sup 3+} phosphor (0.1484, 0.0602) are nearer to the color coordinate for blue color suggested by the color systems EBUPAL/SECAM, sRGB Blue as well as Adobe blue(0.15, 0.06). -- Highlights: • Novel phosphor KSCN:xCe prepared for the first time. • Method is simple, time saving, economical, easy to handle. • Intense, blue, Characteristic Ce{sup 3+} emission at 450 nm. • nUV excitation, suitable for solid state lighting.

TP53 mutations in clinically normal mucosa adjacent to oral carcinomas

DEFF Research Database (Denmark)

Thode, Christenze; Bilde, Anders; von Buchwald, Christian

2010-01-01

BACKGROUND: The tumour-suppressor protein p53 often accumulates in histologically normal epithelium adjacent to oral squamous cell carcinomas (OSCC). We investigated whether this was associated with mutations in TP53, the gene for p53, and might implicate impending malignancy. METHODS: Specimens...... products were separated by denatured gradient gel electrophoresis. Fragments with a deviant DGEE pattern were sequenced. RESULTS: TP53 mutations were found in six of 18 tumours. Fourteen specimens contained histologically normal mucosa adjacent to the tumour; 13 of these showed small clusters of p53...

Neutron scintillator using Ga-doped ZnO phosphor with high detection efficiency

International Nuclear Information System (INIS)

Koyama, Shin; Kinoshita, Atsushi; Fujiwara, Akihiko; Kobayashi, Haruki; Takei, Yoshinori; Nanto, Hidehito; Katagiri, Masaki

2009-01-01

Zinc Oxide (ZnO) family phosphors as phosphor for neutron detector have prepared using Spark Plasma Sintering (SPS) method. The optical properties of ZnO phosphor prepared are investigated. The following results were obtained. Two dominant photoluminescence (PL) emission peaks at 395 nm and 495 nm were observed. The lifetime of the PL emission peak at 395 nm (UV emission band) is about 20 ns, which is suitable for neutron detection. The Ga (30 mol%)-doped ZnO phosphor exhibited an intense UV emission band without the visible emission band. The Ga-doped ZnO phosphor can be prepared at the atmospheric pressure of about 8 Pa using SPS method. It was found that the PL intensity of UV emission band is increased with improving the crystallinity of the ZnO phosphor. (author)

Molecular Alterations of TP53 are a Defining Feature of Ovarian High-Grade Serous Carcinoma: A Rereview of Cases Lacking TP53 Mutations in The Cancer Genome Atlas Ovarian Study.

Science.gov (United States)

Vang, Russell; Levine, Douglas A; Soslow, Robert A; Zaloudek, Charles; Shih, Ie-Ming; Kurman, Robert J

2016-01-01

The Cancer Genome Atlas has reported that 96% of ovarian high-grade serous carcinomas (HGSCs) have TP53 somatic mutations suggesting that mutation of this gene is a defining feature of this neoplasm. In the current study, 5 gynecologic pathologists independently evaluated hematoxylin and eosin slides of 14 available cases from The Cancer Genome Atlas classified as HGSC that lacked a TP53 mutation. The histologic diagnoses rendered by these pathologists and the accompanying molecular genetic data are the subject of this report. Only 1 case (Case 5), which contained a homozygous deletion of TP53, had unanimous interobserver agreement for a diagnosis of pure HGSC. In 1 case (Case 3), all 5 observers (100%) rendered a diagnosis of HGSC; however, 3 observers (60%) noted that the histologic features were not classic for HGSC and suggested this case may have arisen from a low-grade serous carcinoma (arisen from an alternate pathway compared with the usual HGSC). In 2 cases (Cases 4 and 12), only 3 observers (60%) in each case, respectively, interpreted it as having a component of HGSC. In the remaining 10 (71%) of tumors (Cases 1, 2, 6-11, 13, and 14), the consensus diagnosis was not HGSC, with individual diagnoses including low-grade serous carcinoma, high-grade endometrioid carcinoma, HGSC, metastatic carcinoma, clear cell carcinoma, atypical proliferative (borderline) serous tumor, and adenocarcinoma, not otherwise specified. Therefore, 13 (93%) of the tumors (Cases 1-4 and 6-14) were either not a pure HGSC or represented a diagnosis other than HGSC, all with molecular results not characteristic of HGSC. Accordingly, our review of the TP53 wild-type HGSCs reported in The Cancer Genome Atlas suggests that 100% of de novo HGSCs contain TP53 somatic mutations or deletions, with the exception of the rare HGSCs that develop from a low-grade serous tumor precursor. We, therefore, propose that lack of molecular alterations of TP53 are essentially inconsistent with the

Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis

Directory of Open Access Journals (Sweden)

Sarah A. Hansen

2016-10-01

Full Text Available Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and rat models have significant phenotypic and genetic limitations, and often do not recapitulate certain aspects of human disease. We used a marker-assisted speed congenic approach to transfer a well-characterized Tp53-mutant allele from an outbred rat to the genetically inbred Fischer-344 (F344 rat to create the F344-Tp53tm1(EGFP-PacQly/Rrrc (F344-Tp53 strain. On the F344 genetic background, the tumor spectrum shifted, with the primary tumor types being osteosarcomas and meningeal sarcomas, compared to the hepatic hemangiosarcoma and lymphoma identified in the original outbred stock model. The Fischer model is more consistent with the early onset of bone and central nervous system sarcomas found in humans with germline Tp53 mutations. The frequency of osteosarcomas in F344-Tp53 homozygous and heterozygous animals was 57% and 36%, respectively. Tumors were highly representative of human disease radiographically and histologically, with tumors found primarily on long bones with frequent pulmonary metastases. Importantly, the rapid onset of osteosarcomas in this promising new model fills a current void in animal models that recapitulate human pediatric osteosarcomas and could facilitate studies to identify therapeutic targets.

A polymorphism (rs1042522) in TP53 gene is a risk factor for Down Syndrome in Sicilian mothers.

Science.gov (United States)

Salemi, Michele; Barone, Concetta; Salluzzo, Maria Grazia; Giambirtone, Mariaconcetta; Scillato, Francesco; Galati Rando, Rosanna; Romano, Carmelo; Morale, Maria Concetta; Ridolfo, Federico; Romano, Corrado

2017-11-01

Trisomy 21 is the most frequent genetic cause of intellectual disability. Tumor Protein 53 (TP53) gene down-regulation triggers chromosomal instability. A TP53 gene polymorphism c.215G > C (rs1042522) is associated with accumulation of aneuploid cells. We analyzed the TP53 c.215G > C (rs1042522) polymorphism in Sicilian mothers of subjects with Down Syndrome (DS) within a case-control study. Nucleotide polymorphism was detected by pyrosequencing technology. The distribution of TP53 c.215G > C polymorphism showed significant difference between mothers of subjects with DS and controls. Our data show that TP53 c.215G > C polymorphism is a risk factor for DS in Sicilian mothers.

Tilapia Piscidin 4 (TP4 Stimulates Cell Proliferation and Wound Closure in MRSA-Infected Wounds in Mice

Directory of Open Access Journals (Sweden)

Hang-Ning Huang

2015-05-01

Full Text Available Antimicrobial peptides (AMPs are endogenous antibiotics that directly affect microorganisms, and also have a variety of receptor-mediated functions. One such AMP, Tilapia piscidin 4 (TP4, was isolated from Nile tilapia (Oreochromis niloticus; TP4 has antibacterial effects and regulates the innate immune system. The aim of the present study was to characterize the role of TP4 in the regulation of wound closure in mice and proliferation of a keratinocyte cell line (HaCaT and fibroblast cell line (Hs-68. In vitro, TP4 stimulated cell proliferation and activated collagen I, collagen III, and keratinocyte growth factor (KGF gene expression in Hs-68 cells, which induces keratin production by HaCaT cells. This effect was detectable at TP4 concentrations of 6.25 µg/mL in both cell lines. In vivo, TP4 was found to be highly effective at combating peritonitis and wound infection caused by MRSA in mouse models, without inducing adverse behavioral effects or liver or kidney toxicity. Taken together, our results indicate that TP4 enhances the survival rate of mice infected with the bacterial pathogen MRSA through both antimicrobial and wound closure activities mediated by epidermal growth factor (EGF, transforming growth factor (TGF, and vascular endothelial growth factor (VEGF. The peptide is likely involved in antibacterial processes and regulation of tissue homeostasis in infected wounds in mice. Overall, these results suggest that TP4 may be suitable for development as a novel topical agent for wound dressing.

An in vitro comparison of diagnostic abilities of conventional radiography, storage phosphor, and cone beam computed tomography to determine occlusal and approximal caries

Energy Technology Data Exchange (ETDEWEB)

Kayipmaz, Saadettin, E-mail: kayipmaz@ktu.edu.tr [Karadeniz Technical University, Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Farabi, 61080 Trabzon (Turkey); Sezgin, Omer Said, E-mail: omersaidsezgin@gmail.com [Karadeniz Technical University, Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Farabi, 61080 Trabzon (Turkey); Saricaoglu, Senem Tugra, E-mail: senem_tugra@hotmail.com [Karadeniz Technical University, Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Farabi, 61080 Trabzon (Turkey); Can, Gamze, E-mail: gcanktu@yahoo.com [Karadeniz Technical University Faculty of Medicine Department of Public Health (Turkey)

2011-11-15

Aim: The aim of this study was to compare conventional radiography, storage phosphor plate, and cone beam computed tomography for in vitro determination of occlusal and approximal caries. Methods: A total of 72 extracted human premolar and molar teeth were selected. Teeth were radiographed with conventional intraoral radiography, a storage phosphor plate system, and cone beam computed tomography and evaluated by two observers. The teeth were then separated and examined with a stereomicroscope and a scanner at approximately 8x magnification. Results: CBCT was statistically superior to conventional radiography and phosphor plate for determining occlusal caries. No significant difference from CBCT, conventional radiography and the phosphor plate system for determining approximal caries was found. Conclusion: The CBCT system may be used as an auxiliary method for the detection of caries.

An in vitro comparison of diagnostic abilities of conventional radiography, storage phosphor, and cone beam computed tomography to determine occlusal and approximal caries

International Nuclear Information System (INIS)

Kayipmaz, Saadettin; Sezgin, Omer Said; Saricaoglu, Senem Tugra; Can, Gamze

2011-01-01

Aim: The aim of this study was to compare conventional radiography, storage phosphor plate, and cone beam computed tomography for in vitro determination of occlusal and approximal caries. Methods: A total of 72 extracted human premolar and molar teeth were selected. Teeth were radiographed with conventional intraoral radiography, a storage phosphor plate system, and cone beam computed tomography and evaluated by two observers. The teeth were then separated and examined with a stereomicroscope and a scanner at approximately 8x magnification. Results: CBCT was statistically superior to conventional radiography and phosphor plate for determining occlusal caries. No significant difference from CBCT, conventional radiography and the phosphor plate system for determining approximal caries was found. Conclusion: The CBCT system may be used as an auxiliary method for the detection of caries.

Light Converting Inorganic Phosphors for White Light-Emitting Diodes

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Chiao-Wen Yeh

2010-03-01

Full Text Available White light-emitting diodes (WLEDs have matched the emission efficiency of florescent lights and will rapidly spread as light source for homes and offices in the next 5 to 10 years. WLEDs provide a light element having a semiconductor light emitting layer (blue or near-ultraviolet (nUV LEDs and photoluminescence phosphors. These solid-state LED lamps, rather than organic light emitting diode (OLED or polymer light-emitting diode (PLED, have a number of advantages over conventional incandescent bulbs and halogen lamps, such as high efficiency to convert electrical energy into light, reliability and long operating lifetime. To meet with the further requirement of high color rendering index, warm light with low color temperature, high thermal stability and higher energy efficiency for WLEDs, new phosphors that can absorb excitation energy from blue or nUV LEDs and generate visible emissions efficiently are desired. The criteria of choosing the best phosphors, for blue (450-480 nm and nUV (380-400 nm LEDs, strongly depends on the absorption and emission of the phosphors. Moreover, the balance of light between the emission from blue-nUV LEDs and the emissions from phosphors (such as yellow from Y3Al5O12:Ce3+ is important to obtain white light with proper color rendering index and color temperature. Here, we will review the status of phosphors for LEDs and prospect the future development.

Light Converting Inorganic Phosphors for White Light-Emitting Diodes

Science.gov (United States)

Chen, Lei; Lin, Chun-Che; Yeh, Chiao-Wen; Liu, Ru-Shi

2010-01-01

White light-emitting diodes (WLEDs) have matched the emission efficiency of florescent lights and will rapidly spread as light source for homes and offices in the next 5 to 10 years. WLEDs provide a light element having a semiconductor light emitting layer (blue or near-ultraviolet (nUV) LEDs) and photoluminescence phosphors. These solid-state LED lamps, rather than organic light emitting diode (OLED) or polymer light-emitting diode (PLED), have a number of advantages over conventional incandescent bulbs and halogen lamps, such as high efficiency to convert electrical energy into light, reliability and long operating lifetime. To meet with the further requirement of high color rendering index, warm light with low color temperature, high thermal stability and higher energy efficiency for WLEDs, new phosphors that can absorb excitation energy from blue or nUV LEDs and generate visible emissions efficiently are desired. The criteria of choosing the best phosphors, for blue (450−480 nm) and nUV (380−400 nm) LEDs, strongly depends on the absorption and emission of the phosphors. Moreover, the balance of light between the emission from blue-nUV LEDs and the emissions from phosphors (such as yellow from Y3Al5O12:Ce3+) is important to obtain white light with proper color rendering index and color temperature. Here, we will review the status of phosphors for LEDs and prospect the future development.

Radiation-induced defects in manganese-doped lithium tetraborate phosphor.

Science.gov (United States)

Annalakshmi, O; Jose, M T; Madhusoodanan, U; Sridevi, J; Venkatraman, B; Amarendra, G; Mandal, A B

2015-01-01

Lithium tetraborate doped with manganese synthesised by solid-state sintering technique exhibits a dosimetric peak at 280°C. The high-temperature glow curve results in no fading for three months. The sensitivity of Li2B4O7:Mn is determined to be 0.9 times that of TLD-100. The infrared spectrum of this phosphor indicates the presence of bond vibrations corresponding to BO4 tetrahedral and BO3 triangles. The mechanism for thermoluminescence in this phosphor was proposed based on the thermoluminescence (TL) emission spectra, kinetic analysis of TL glow curves and electron paramagnetic resonance (EPR) measurements on non-irradiated and gamma-irradiated phosphors. It was identified that oxygen vacancies and Boron oxygen hole centre (BOHC) are the electron and hole trap centres for TL in this phosphor. When the phosphor is heated, the electrons are released from the electron trap and recombine with the trapped holes. The excitation energy during the recombination is transferred to the nearby Mn(2+) ions, which emit light at 580 nm. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

New Silicate Phosphors for a White LED(Electronic Displays)

OpenAIRE

Toda, Kenji; Kawakami, Yoshitaka; Kousaka, Shin-ichiro; Ito, Yutaka; Komeno, Akira; Uematsu, Kazuyoshi; Sato, Mineo

2006-01-01

We focus on the development of new silicate phosphors for a white LED. In the europium doped silicate system, four LED phosphor candidates-Li_2SrSiO_4:Eu^, Ba_9Sc_2Si_6O_:Eu^, Ca_3Si_2O_7:Eu^ and Ba_2MgSi_2O_7:Eu^ were found. Luminescent properties under near UV and visible excitation were investigated for the new Eu^ doped LED silicate phosphors. These new phosphors have a relatively strong absorption band in a long wavelength region.

Structural Biology of CI from Phage TP901-1

DEFF Research Database (Denmark)

Rasmussen, Kim Krighaar

(CTD), separated by a linker of various lengths. The NTD is responsible for DNA binding and the CTD is responsible for oligomerization of the CI protein. A Helix-turn-Helix motif is usually responsible for DNA binding. This thesis presents a structural characterization of the CI repressor from TP901...... condition of the CTD, responsible for the arrangement of the hexameric CI repressor. The arrangement of the CI repressor for TP901-1 has previously been described to have 32 point group symmetry based on SAXS studies. The CTD crystallizes with P3121 or P3221 symmetry with one molecule in the asymmetric unit......-length CI can only be answered unambiguously by solving the CTD crystal structure or by use of alternative techniques on the full-length CI....

Search for a developed method for the determination of Fe2 and Fe3 in Syrian Phosphoric acid

International Nuclear Information System (INIS)

Elian, Nuzhat; Kalak, Issam

1988-08-01

Phosphoric acid is the most important precursor for uranium production in Syria. Uranium extraction from phosphoric acid depends on the chemical composition of the acid, and most important is the relation between the proportions of iron I I/iron I II, and uranium I V/uranium V I, this proportion plays a very important role in different steps of the extraction. For this purposes two methods for determination of Iron I I and Iron I II in Syrian wet phosphoric acid spectrophotometrically were studied. The first one used 1.10 phenanthroline as complex agent. Iron I I formed red complex with 1.10 phenonstholine in the range of pH between 4 and 6, for determination of total iron. Iron I II was reduced to Iron I I with hydroxylamine hydrochloride. The second method used sulfosalycilic acid, Iron I II formed a yellow complex with sulfosalycilic acid. Total iron was determined in ammonium medium, but Iron I II was determined in pH=1.5. The sensibility of the tow methods and stability of their complex have been studied in normal laboratory conditions. 45 refs., 4 figs. (author)

Gaining insights into the codon usage patterns of TP53 gene across eight mammalian species.

Directory of Open Access Journals (Sweden)

Tarikul Huda Mazumder

Full Text Available TP53 gene is known as the "guardian of the genome" as it plays a vital role in regulating cell cycle, cell proliferation, DNA damage repair, initiation of programmed cell death and suppressing tumor growth. Non uniform usage of synonymous codons for a specific amino acid during translation of protein known as codon usage bias (CUB is a unique property of the genome and shows species specific deviation. Analysis of codon usage bias with compositional dynamics of coding sequences has contributed to the better understanding of the molecular mechanism and the evolution of a particular gene. In this study, the complete nucleotide coding sequences of TP53 gene from eight different mammalian species were used for CUB analysis. Our results showed that the codon usage patterns in TP53 gene across different mammalian species has been influenced by GC bias particularly GC3 and a moderate bias exists in the codon usage of TP53 gene. Moreover, we observed that nature has highly favored the most over represented codon CTG for leucine amino acid but selected against the ATA codon for isoleucine in TP53 gene across all mammalian species during the course of evolution.

A novel red-emitting phosphor for white light-emitting diodes

International Nuclear Information System (INIS)

Ren, Fuqiang; Chen, Donghua

2010-01-01

A novel red-emitting phosphor of Eu 3+ -activated molybdate was prepared at 850 o C by a modified solid-state reaction. Photoluminescence (PL) results showed that the phosphor can be efficiently excited by UV-visible light from 350 to 550 nm, and exhibited bright red emission at 614 nm. XPS are taken to investigate the structure and compositions of this material. The crystallization and particle sizes of the phosphor have been investigated by using powder X-ray diffraction (XRD) and transmission electron microscopy (TEM). TEM images show that the grain size of the phosphor is about 30 nm which is in full agreement with the theoretical calculation data from the XRD patterns.

Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively.

Directory of Open Access Journals (Sweden)

Lenka Mikalová

2017-03-01

Full Text Available Treponema pallidum subsp. endemicum (TEN is the causative agent of endemic syphilis (bejel. An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion from a patient that returned to France from Pakistan.The TEN 11q/j isolate was characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, the 11q/j isolate clustered with TEN strains Bosnia A and Iraq B as expected from previous TEN classification of the 11q/j isolate. However, the 11q/j sequence in a 505 bp-long region at the TP0488 locus was similar to Treponema pallidum subsp. pallidum (TPA strains, but not to TEN Bosnia A and Iraq B sequences, suggesting a recombination event at this locus. Similarly, the 11q/j sequence in a 613 bp-long region at the TP0548 locus was similar to Treponema pallidum subsp. pertenue (TPE strains, but not to TEN sequences.A detailed analysis of two recombinant loci found in the 11q/j clinical isolate revealed that the recombination event occurred just once, in the TP0488, with the donor sequence originating from a TPA strain. Since TEN Bosnia A and Iraq B were found to contain TPA-like sequences at the TP0548 locus, the recombination at TP0548 took place in a treponeme that was an ancestor to both TEN Bosnia A and Iraq B. The sequence of 11q/j isolate in TP0548 represents an ancestral TEN sequence that is similar to yaws-causing treponemes. In addition to the importance of the 11q/j isolate for reconstruction of the TEN phylogeny, this case emphasizes the possible role of TEN strains in development of syphilis-like lesions.

Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations

DEFF Research Database (Denmark)

Farooqui, Mohammed Z H; Valdez, Janet; Martyr, Sabrina

2015-01-01

BACKGROUND: Patients with chronic lymphocytic leukaemia (CLL) with TP53 aberrations respond poorly to first-line chemoimmunotherapy, resulting in early relapse and short survival. We investigated the safety and activity of ibrutinib in previously untreated and relapsed or refractory CLL with TP53...... aberrations. METHODS: In this investigator-initiated, single-arm phase 2 study, we enrolled eligible adult patients with active CLL with TP53 aberrations at the National Institutes of Health Clinical Center (Bethesda, MD, USA). Patients received 28-day cycles of ibrutinib 420 mg orally once daily until...... in one (2%) patient. INTERPRETATION: The activity and safety profile of single-agent ibrutinib in CLL with TP53 aberrations is encouraging and supports its consideration as a novel treatment option for patients with this high-risk disease in both first-line and second-line settings. FUNDING: Intramural...

ELISA with double antigen sandwich for screening specific serum anti-TP antibody in blood donors

International Nuclear Information System (INIS)

Wang Yiqing; Shi Zhixu

2002-01-01

Objective: To select a sensitive and specific laboratory examination suitable for screening serum anti-TP antibody in blood donors. Methods: The serum anti-TP antibody in 11271 blood donors were detected using ELISA with double antigen sandwich and the outcomes were compared with those using RPR assay. The conflicting specimen were confirmed by repeating the test with TPHA assay. Results: The positive rates of serum anti-TP antibody by ELISA with double antigen sandwich and RPR was 0.36% (41/11271) and 0.26% (29/11271), respectively. The coincidence of the detecting outcomes by ELISA with double antigen sandwich and RPR with TPHA was 97.5% (40/41) and 63.41%(26/41) respectively. Conclusion: Compared with RPR assay, ELISA with double antigen sandwich has higher sensibility and specificity for screening serum anti-TP antibody in blood donors

Perioperative management of endocrine insufficiency after total pancreatectomy for neoplasia.

Science.gov (United States)

Maker, Ajay V; Sheikh, Raashid; Bhagia, Vinita

2017-09-01

Indications for total pancreatectomy (TP) have increased, including for diffuse main duct intrapapillary mucinous neoplasms of the pancreas and malignancy; therefore, the need persists for surgeons to develop appropriate endocrine post-operative management strategies. The brittle diabetes after TP differs from type 1/2 diabetes in that patients have absolute deficiency of insulin and functional glucagon. This makes glucose management challenging, complicates recovery, and predisposes to hospital readmissions. This article aims to define the disease, describe the cause for its occurrence, review the anatomy of the endocrine pancreas, and explain how this condition differs from diabetes mellitus in the setting of post-operative management. The morbidity and mortality of post-TP endocrine insufficiency and practical treatment strategies are systematically reviewed from the literature. Finally, an evidence-based treatment algorithm is created for the practicing pancreatic surgeon and their care team of endocrinologists to aid in managing these complex patients. A PubMed, Science Citation Index/Social sciences Citation Index, and Cochrane Evidence-Based Medicine database search was undertaken along with extensive backward search of the references of published articles to identify studies evaluating endocrine morbidity and treatment after TP and to establish an evidence-based treatment strategy. Indications for TP and the etiology of pancreatogenic diabetes are reviewed. After TP, ~80% patients develop hypoglycemic episodes and 40% experience severe hypoglycemia, resulting in 0-8% mortality and 25-45% morbidity. Referral to a nutritionist and endocrinologist for patient education before surgery followed by surgical reevaluation to determine if the patient has the appropriate understanding, support, and resources preoperatively has significantly reduced morbidity and mortality. The use of modern recombinant long-acting insulin analogues, continuous subcutaneous insulin

Separation of rare earths from solutions of phosphoric acid

International Nuclear Information System (INIS)

Jones, E.A.

1977-01-01

Rare earths are separated from 6M phosphoric acid by adsorption onto cation resin BIORAD AG50W-X8. The phosphoric acid is then washed from the column, and the rare earths are eluted with 4M hydrochloric acid

Surface-Plasmon-Enhanced Emissions of Phosphors with Au Nanoparticles Embedded in ITO

Energy Technology Data Exchange (ETDEWEB)

Kim, Ja-Yeon [Korea Photonics Technology Institute (KOPTI), Gwangju (Korea, Republic of); Oh, Seung Jong; Park, Hyun-Sun; Kim, Min-Woo; Cho, Yoo-Hyun; Kwon, Min-Ki [Chosun University, Gwangju (Korea, Republic of)

2017-03-15

Au nanoparticles were embedded in a transparent conducting layer of indium tin oxide in order to evaluate the feasibility of applying a surface-plasmon (SP)-enhanced phosphor to light-emitting diodes (LEDs). The efficiency of the phosphor was improved by energy matching between the phosphor and the SP of the Au nanoparticles. After the density of the Au nanoparticles and the thickness of the spacer layer had been optimized, the efficiency of a green phosphor was improved by 64% compared to that of an isolated green phosphor. This work provides a way to fabricate high-efficiency LEDs with high color-rendering indices and wide color gamuts in white LEDs.

Effect of Thermal Annealing on Carbon in In-situ Phosphorous-Doped Si1-xCx films

International Nuclear Information System (INIS)

Adam, Thomas; Loubet, Nicolas; Reznicek, Alexander; Paruchuri, Vamsi; Sampson, Ron; Sadana, Devendra

2012-01-01

The effect of thermal heat treatment on carbon in in-situ phosphorous-doped silicon-carbon is studied as a function of annealing temperature and type. Films of 0 to 2% carbon were deposited using cyclic chemical vapor deposition at reduced pressures. Secondary ion-mass spectroscopy and high-resolution X-ray diffraction were employed to extract the total and substitutional carbon concentration in samples with phosphorous levels of mid-10 20 cm -3 . It was found that millisecond laser annealing drastically improves substitutionality while high thermal budget treatments (furnace, rapid-thermal, or spike annealing) resulted in an almost complete loss of substitutional carbon, independent of preceding or subsequent laser heat treatments.

Ultraviolet /UV/ sensitive phosphors for silicon imaging detectors

Science.gov (United States)

Viehmann, W.; Cowens, M. W.; Butner, C. L.

1981-01-01

The fluorescence properties of UV sensitive organic phosphors and the radiometric properties of phosphor coated silicon detectors in the VUV, UV, and visible wavelengths are described. With evaporated films of coronene and liumogen, effective quantum efficiencies of up to 20% have been achieved on silicon photodiodes in the vacuum UV. With thin films of methylmethacrylate (acrylic), which are doped with organic laser dyes and deposited from solution, detector quantum efficiencies of the order of 15% for wavelengths of 120-165 nm and of 40% for wavelengths above 190 nm have been obtained. The phosphor coatings also act as antireflection coatings and thereby enhance the response of coated devices throughout the visible and near IR.

Phosphorous loads evaluation from soil

International Nuclear Information System (INIS)

Mezzanotte, V.

1996-01-01

With reference to the well known difficulty of quantifying non point phosphorous loads, as well as to their growing relative importance where point source leads decrease, a literature review has been carried out concerning soil export coefficients. On such basis, the values which seem to be the most appropriate for Italy have been estimated for different land use categories. The main mechanisms determining non point phosphorous load generation and the factors affecting their importance are also described. In the end, criteria for estimating the importance of non point sources in a basin are suggested to be used for deciding whether a traditional, parametric assessment (inevitably involving a certain error) can be acceptable or experimental measures are needed

Lab-on-a-chip based total-phosphorus analysis device utilizing a photocatalytic reaction

Science.gov (United States)

Jung, Dong Geon; Jung, Daewoong; Kong, Seong Ho

2018-02-01

A lab-on-a-chip (LOC) device for total phosphorus (TP) analysis was fabricated for water quality monitoring. Many commercially available TP analysis systems used to estimate water quality have good sensitivity and accuracy. However, these systems also have many disadvantages such as bulky size, complex pretreatment processes, and high cost, which limit their application. In particular, conventional TP analysis systems require an indispensable pretreatment step, in which the fluidic analyte is heated to 120 °C for 30 min to release the dissolved phosphate, because many phosphates are soluble in water at a standard temperature and pressure. In addition, this pretreatment process requires elevated pressures of up to 1.1 kg cm-2 in order to prevent the evaporation of the heated analyte. Because of these limiting conditions required by the pretreatment processes used in conventional systems, it is difficult to miniaturize TP analysis systems. In this study, we employed a photocatalytic reaction in the pretreatment process. The reaction was carried out by illuminating a photocatalytic titanium dioxide (TiO2) surface formed in a microfluidic channel with ultraviolet (UV) light. This pretreatment process does not require elevated temperatures and pressures. By applying this simplified, photocatalytic-reaction-based pretreatment process to a TP analysis system, greater degrees of freedom are conferred to the design and fabrication of LOC devices for TP monitoring. The fabricated LOC device presented in this paper was characterized by measuring the TP concentration of an unknown sample, and comparing the results with those measured by a conventional TP analysis system. The TP concentrations of the unknown sample measured by the proposed LOC device and the conventional TP analysis system were 0.018 mgP/25 mL and 0.019 mgP/25 mL, respectively. The experimental results revealed that the proposed LOC device had a performance comparable to the conventional bulky TP analysis

Total phenol content and antioxidant activity of water solutions of plant extracts

Directory of Open Access Journals (Sweden)

Mirela Kopjar

2009-01-01

Full Text Available Water solutions of extracts were investigated for total phenol content, flavonoid content and antioxidant activity. Susceptibility to degradation of water solutions of plant extracts, under light and in the dark, during storage at room temperature was investigated in order to determine their stability prior to their application for fortification of food products. Large dispersion of total phenol (TP content in the investigated model solutions of selected extracts (olive leaves, green tea, red grape, red wine, pine bark PE 5:1, pine bark PE 95 %, resveratrol, ranging from 11.10 mg GAE/100 mL to 92.19 mg GAE/100 mL was observed. Consequently, large dispersion of total flavonoids (TF content (8.89 mg to 61.75 mg CTE/100 mL was also observed. Since phenols have been mostly responsible for antioxidant activity of extracts, in most cases, antioxidant activity followed the TP content. That was proven by estimation of correlation coefficient between the total phenol content and antioxidant activity. Correlation coefficients between investigated parameters ranged from 0.5749 to 0.9604. During storage of 5 weeks at room temperature loss of phenols and flavonoids occurred. Antioxidant activity decreased with the decrease of TP and TF content. Degradations of phenols and flavonoids were more pronounced in samples stored at light.

Analysis of phosphoric ore bacterial and eucaryal microbial diversity ...

African Journals Online (AJOL)

These findings provided new opportunities into phosphoric ore microbiology that could be useful in biological system removing waste gases generated from the phosphoric industry. Keywords: Microbial community, bacteria, archaea, eucarya, mining residue. African Journal of Biotechnology, Vol 13(30) 3023-3029 ...

Total pollution effect of urban surface runoff.

Science.gov (United States)

Luo, Hongbing; Luo, Lin; Huang, Gu; Liu, Ping; Li, Jingxian; Hu, Sheng; Wang, Fuxiang; Xu, Rui; Huang, Xiaoxue

2009-01-01

For pollution research with regard to urban surface runoff, most sampling strategies to date have focused on differences in land usage. With single land-use sampling, total surface runoff pollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river, this study assessed the total urban surface runoff pollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China. The water quality monitoring indices were COD (chemical oxygen demand), TSS (total suspend solid), TP (total phosphorus), TN (total nitrogen) and BOD (biochemical oxygen demand). The sums of total pollution loads discharged into the river for the four indices of COD, TSS, TN, and TP over all seven rainfall events were very different. The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters: rainfall intensity, total land area, impervious land area, and pervious land area. In order to treat surface runoff pollution, the values of MFF30 (mass first flush ratio) and FF30 (first 30% of runoff volume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs (best management practices) facilities.

Field and Evaluation Methods Used to Test the Performance of a Stormceptor® Class 1 Stormwater Treatment Device in Australia

Directory of Open Access Journals (Sweden)

Peter Nichols

2015-12-01

Full Text Available Field testing of a proprietary stormwater treatment device was undertaken over 14 months at a site located in Nambour, South East Queensland. Testing was undertaken to evaluate the pollution removal performance of a Stormceptor® treatment train for removing total suspended solids (TSS, total nitrogen (TN and total phosphorous (TP from stormwater runoff. Water quality sampling was undertaken using natural rainfall events complying with an a priori sampling protocol. More than 59 rain events were monitored, of which 18 were found to comply with the accepted sampling protocol. The efficiency ratios (ER observed for the treatment device were found to be 83% for TSS, 11% for TP and 23% for TN. Although adequately removing TSS, additional system components, such as engineered filters, would be required to satisfy minimum local pollution removal regulations. The results of dry weather sampling tests did not conclusively demonstrate that pollutants were exported between storm events or that pollution concentrations increased significantly over time.

Radioactivity Content in Phosphoric Acid Used for Fertilizer Production

International Nuclear Information System (INIS)

Ibrahiem, N.M.; Hamed, A.A.

2003-01-01

Uranium content in phosphoric acid used fertilizer production was measured by alpha spectrometry, laser fluorimetry high resolution gamma spectrometry. Also, polonium-210 content was determined in phosphoric acid by alpha spectrometry. Uranium-234 and uranium-238 concentrations, measured by alpha spectroscopy, were found to be 601 and 507 Bq I -1 , respectively. Total uranium content obtained by laser fluorimetry was about 545 BqI - (45.4ppm). Gamma spectroscopy analysis gave the concentrations of 40 K, 238 U, 235 U, 214 Pb, 214 Bi and 208 TI, as 17,644,19.5, 1.2,1.3 and 9.4 Bq I -1 , respectively. Polonium-210 concentration was found to be about 3.1 Bq I -1 . Uranium-232 and polonium-208 were used as yield tracers, for alpha measurements of uranium and polonium, respectively. Samples of the tri-super phosphate (TSP) and single-super phosphate (SSP) fertilizers and the phosphogypsum produced were also analyzed by gamma spectroscopy. Uranium content in both phosphate fertilizers was 3205 and 1440 Bq Kg -1 for 238 U and 83 and 35 Bq Kg -1 for, 235 U respectively

Intravascular imaging with a storage phosphor detector

Energy Technology Data Exchange (ETDEWEB)

Shikhaliev, Polad M; Petrek, Peter; Matthews, Kenneth L II; Fritz, Shannon G [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA (United States); Bujenovic, L Steven [PET Imaging Center, Our Lady of the Lake Medical Center, Baton Rouge, LA (United States); Xu Tong, E-mail: pshikhal@lsu.ed [Department of Physics, Carleton University, Ottawa (Canada)

2010-05-21

The aim of this study is to develop and test an intravascular positron imaging system based on a storage phosphor detector for imaging and detecting vulnerable plaques of human coronary arteries. The radiotracer F18-FDG accumulates in vulnerable plaques with inflammation of the overlying cap. The vulnerable plaques can, therefore, be imaged by recording positrons emitted from F18-FDG with a detector inserted into the artery. A prototype intravascular detector was constructed based on storage phosphor. The detector uses a flexible storage phosphor tube with 55 mm length, 2 mm diameter and 0.28 mm wall thickness. The intravascular detector is guided into the vessel using x-ray fluoroscopy and the accumulated x-ray signal must be erased prior to positron imaging. For this purpose, a light diffuser, 0.9 mm in diameter and 55 mm in length, was inserted into the detector tube. The light diffuser was connected to a laser source through a 2 m long optical fiber. The diffuser redirected the 0.38 W laser light to the inner surface of the phosphor detector to erase it. A heart phantom with 300 cm{sup 3} volume and three coronary arteries with 3.2 mm diameter and with several plaques was constructed. FDG solution with 0.5 {mu}Ci cm{sup -3} activity concentration was filled in the heart and coronary arteries. The detector was inserted in a coronary artery and the signal from the plaques and surrounding background activity was recorded for 2 min. Then the phosphor detector was extracted and read out using a storage phosphor reader. The light diffuser erased the signal resulting from fluoroscopic exposure to level below that encountered during positron imaging. Vulnerable plaques with area activities higher than 1.2 nCi mm{sup -2} were visualized by the detector. This activity is a factor of 10-20 lower than that expected in human vulnerable plaques. The detector was able to image the internal surface of the coronary vessels with 50 mm length and 360{sup 0} circumference. Spatial

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.

Directory of Open Access Journals (Sweden)

Tuoen Liu

Full Text Available Myelodysplastic syndromes (MDS are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis in MDS remains unknown. Up to 25% of MDS patients harbor and acquired interstitial deletion on the long arm of chromosome 5 [del(5q], creating haploinsufficiency for a large set of genes including HSPA9. Knockdown of HSPA9 in primary human CD34+ hematopoietic progenitor cells significantly inhibits growth and increases apoptosis. We show here that HSPA9 knockdown is associated with increased TP53 expression and activity, resulting in increased expression of target genes BAX and p21. HSPA9 protein interacts with TP53 in CD34+ cells and knockdown of HSPA9 increases nuclear TP53 levels, providing a possible mechanism for regulation of TP53 by HSPA9 haploinsufficiency in hematopoietic cells. Concurrent knockdown of TP53 and HSPA9 rescued the increased apoptosis observed in CD34+ cells following knockdown of HSPA9. Reduction of HSPA9 below 50% results in severe inhibition of cell growth, suggesting that del(5q cells may be preferentially sensitive to further reductions of HSPA9 below 50%, thus providing a genetic vulnerability to del(5q cells. Treatment of bone marrow cells with MKT-077, an HSPA9 inhibitor, induced apoptosis in a higher percentage of cells from MDS patients with del(5q compared to non-del(5q MDS patients and normal donor cells. Collectively, these findings indicate that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q-associated MDS.

Evaluation of the Lumipulse G TP-N Chemiluminescent Immunoassay as a Syphilis Screening Test.

Science.gov (United States)

Ortiz, Daniel A; Loeffelholz, Michael J

2017-11-01

A syphilis diagnosis is often aided by the detection of treponemal and nontreponemal antibodies. Automated treponemal antibody detection systems enable high-volume clinical laboratories to perform syphilis screening at a faster pace with lower labor costs. The Lumipulse G TP-N chemiluminescent immunoassay is an automated system that qualitatively detects IgG and IgM antibodies against Treponema pallidum antigens in human serum and plasma. To assess performance characteristics and workflow efficiency, the Lumipulse G TP-N assay was compared to the Bioplex 2200 Syphilis IgG multiplex flow immunoassay. Among the 4,134 routine and HIV samples tested by the two automated assays, the percentage of agreement was excellent at 99.0% (95% confidence interval [CI], 98.6% to 99.2%; κ, 0.89), with the Lumipulse G TP-N having a shorter time to first and subsequent results. All specimens with reactive syphilis screening results were further tested by rapid plasma reagin (RPR) and Treponema pallidum particle agglutination (TP·PA) testing ( n = 231). The results from the RPR-reactive samples ( n = 82) showed complete concordance with the two automated assays, while the TP·PA assay displayed some discrepancies. The positive percent agreement (PPA) and negative percent agreement (NPA) between the TP·PA test and the Lumipulse G TP-N test were 98.9% and 77.3%, respectively. The Bioplex 2200 Syphilis IgG immunoassay displayed a similar PPA (100%) but a substantially lower NPA (15.9%). Patient chart reviews of discrepant results suggested that the Lumipulse G TP-N assay produced 27 fewer falsely reactive results and can reduce the amount of additional confirmatory RPR and TP·PA testing needed. The analogous performance characteristics of the two automated systems indicate that the Lumipulse G TP-N assay is suitable for high-throughput syphilis screening. Copyright © 2017 American Society for Microbiology.

Development of BaSO sub 4 :Eu thermoluminescence phosphor

CERN Document Server

Madhusoodanan, U; Lakshmanan, A R

1999-01-01

A highly sensitive thermoluminescence (TL) phosphor based on BaSO sub 4 :Eu was developed following the coprecipitation technique and firing in argon atmosphere at 1123 K. Photoluminescence studies confirm that firing in argon atmosphere instead of air increased the incorporation of Eu ions in 2+ valence state. At low gamma-ray doses, its TL sensitivity is nearly 2 to 3 times higher than that of CaSO sub 4 :Dy phosphor. The other salient features of this BaSO sub 4 :Eu TL phosphor are a constant glow curve shape and a nearly linear gamma-ray dose response.

Rare Earth Doped Lanthanum Calcium Borate Polycrystalline Red Phosphors

Directory of Open Access Journals (Sweden)

H. H. Xiong

2014-01-01

Full Text Available Single-phased Sm3+ doped lanthanum calcium borate (SmxLa2−xCaB10O19, SLCB, x=0.06 polycrystalline red phosphor was prepared by solid-state reaction method. The phosphor has two main excitation peaks located at 398.5 nm and 469.0 nm, which are nicely in accordance with the emitting wavelengths of commercial near-UV and blue light emitting diode chips. Under the excitation of 398.0 nm, the dominant red emission of Sm3+ in SLCB phosphor is centered at 598.0 nm corresponding to the transition of 4G5/2 → 6H7/2. The Eu3+ fluorescence in the red spectral region is applied as a spectroscopic probe to reveal the local site symmetry in the host lattice and, hence, Judd-Ofelt parameters Ωt  (t=2, 4 of Eu3+ in the phosphor matrix are derived to be 3.62×10-20 and 1.97×10-20 cm2, indicating a high asymmetrical and strong covalent environment around rare earth luminescence centers. Herein, the red phosphors are promising good candidates employed in white light emitting diodes (LEDs illumination.

Validación del Cuestionario de Creencias Centrales de los Trastornos de la Personalidad (CCE-TP en población colombiana

Directory of Open Access Journals (Sweden)

Nora Helena Londoño A.

2010-07-01

Full Text Available Se construyó un cuestionario para evaluar creencias centrales asociadas con los trastornos de la personalidad, fundamentadas en el Modelo de la Terapia Cognitiva. Se realizó el análisis estructural y la validez de contenido de la prueba en población universitaria de la ciudad de Medellín, Colombia. La muestra fue representativa y elegida al azar a través de un procedimiento polietápico. Un número de 809 estudiantes universitarios contestaron el cuestionario de creencias centrales de los trastornos de la personalidad (CCE-TP. Se realizó un análisis factorial exploratorio de la prueba, reagrupándose los ítems en 14 factores (F que representan el 61,3% de la varianza. F1: CCE-TP antisocial (8 ítems, a 0,839; F2: CCE-TP esquizotípico/límite (8 ítems, a 0,846; F3: CCE-TP histriónico/patrón seductor (6 ítems, a 0,833; F4: CCE-TP paranoide (6 ítems, a 0,836; F5: CCE-TP por evitación / autopercepción negativa (5 ítems, a 0,755; F6: CCE-TP por dependencia (5 ítems, a 0,797; F7: CCE-TP histriónico/ dependencia emocional (4 ítems, a 0,755; F8: CCETP obsesivo-compulsivo/perfeccionista (4 ítems, a 0,808; F9: CCE-TP por evitación/hipersensible (4 ítems, a 0,766; F10: CCE-TP obsesivo-compulsivo/ crítico frente a los demás (3 ítems, a 0,851; F11: CCE-TP narcisista (4 ítems, a 0,717; F12: CCE-TP pasivo-agresivo / temor a ser dominado (3 ítems, a 0,719; F13: CCE-TP pasivo-agresivo/crítico frente a la autoridad (3 ítems, a 0,685, y F14: CCE-TP esquizoide (2 ítems, a 0,774. El alfa de Cronbach de la prueba fue de 0,931.

Validación del Cuestionario de Creencias Centrales de los Trastornos de la Personalidad (CCE-TP en población colombiana

Directory of Open Access Journals (Sweden)

Diego Castrillón M.

2007-06-01

Full Text Available Se construyó un cuestionario para evaluar creencias centrales asociadas con los trastornos de la personalidad, fundamentadas en el Modelo de la Terapia Cognitiva. Se realizó el análisis estructural y la validez de contenido de la prueba en población universitaria de la ciudad de Medellín, Colombia. La muestra fue representativa y elegida al azar a través de un procedimiento polietápico. Un número de 809 estudiantes universitarios contestaron el cuestionario de creencias centrales de los trastornos de la personalidad (CCE-TP. Se realizó un análisis factorial exploratorio de la prueba, reagrupándose los ítems en 14 factores (F que representan el 61,3% de la varianza. F1: CCE-TP antisocial (8 ítems, a 0,839; F2: CCE-TP esquizotípico/límite (8 ítems, a 0,846; F3: CCE-TP histriónico/patrón seductor (6 ítems, a 0,833; F4: CCE-TP paranoide (6 ítems, a 0,836; F5: CCE-TP por evitación / autopercepción negativa (5 ítems, a 0,755; F6: CCE-TP por dependencia (5 ítems, a 0,797; F7: CCE-TP histriónico/dependencia emocional (4 ítems, a 0,755; F8: CCETP obsesivo-compulsivo/perfeccionista (4 ítems, a 0,808; F9: CCE-TP por evitación/hipersensible (4 ítems, a 0,766; F10: CCE-TP obsesivo-compulsivo/ crítico frente a los demás (3 ítems, a 0,851; F11: CCE-TP narcisista (4 ítems, a 0,717; F12: CCE-TP pasivo-agresivo / temor a ser dominado (3 ítems, a 0,719; F13: CCE-TP pasivo-agresivo/crítico frente a la autoridad (3 ítems, a 0,685, y F14: CCE-TP esquizoide (2 ítems, a 0,774. El alfa de Cronbach de la prueba fue de 0,931.

Photoluminescence studies on holmium (III) and praseodymium (III) doped calcium borophosphate (CBP) phosphors

Science.gov (United States)

Reddy Prasad, V.; Damodaraiah, S.; Devara, S. N.; Ratnakaram, Y. C.

2018-05-01

Using solid state reaction method, Ho3+ and Pr3+ doped calcium borophosphate (CBP) phosphors were prepared. These phosphors were characterized using XRD, SEM, FT-IR, 31P solid state NMR, photoluminescence (PL) and decay profiles. Structural details were discussed from XRD and FT-IR spectra. From 31P NMR spectra of these phosphors, mono-phosphate complexes Q0-(PO43-) were observed. Photoluminescence spectra were measured for both Ho3+ and Pr3+ doped calcium borophosphate phosphors and the spectra were studied for different concentrations. Decay curves were obtained for the excited level, 5F4+5S2 of Ho3+ and 1D2 level of Pr3+ in these calcium borophosphate phosphors and lifetimes were measured. CIE color chromaticity diagrams are drawn for these two rare earth ions in calcium borophosphate phosphors. Results show that Ho3+ and Pr3+ doped CBP phosphors might be served as green and red luminescence materials.

Preparation of red phosphor (Y, Gd)BO3:Eu by soft chemistry methods

International Nuclear Information System (INIS)

Cui Xiangzhong; Zhuang Weidong; Yu Zhijian; Xia Tian; Huang Xiaowei; Li Hongwei

2008-01-01

The three soft chemistry methods were employed to prepare the red phosphor (Y, Gd)BO 3 :Eu, such as coprecipitation-combustion method, salt assisted combustion method and emulsion method. The main factors affecting particle size, particle distribution and luminescent properties of the product were investigated in detail, and as a result, the preparation processes were optimized. The phosphors were characterized by X-ray diffraction (XRD), scanning electronic microscope (SEM), transmission electronic microscope (TEM) and vacuum ultraviolet (VUV) spectra. Results reveal that phosphors with different morphology, small particle size and high luminescence intensity could be obtained by soft chemistry methods. The difference between the luminescence properties of phosphors in this work and commercial rare earth borate phosphor is discussed. The phosphor with grain shape and high luminescence intensity could be prepared by coprecipitation-combustion method, nanophosphor could be prepared by salt assisted combustion method, and spherical phosphor with a narrow size distribution could be obtained by using emulsion method

Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A> methylation

DEFF Research Database (Denmark)

Asmar, Fazila; Hother, Christoffer; Kulosman, Gorjan

2014-01-01

and MIR34A methylation ("double hit") and these patients have an exceedingly poor prognosis with a median survival of 9.4 months (Phit") influence on survival. The TP53/MIR34A "double-hit" is an independent...... negative prognostic factor for survival (P=0.0002). In 2 DLBCL-cell lines with both TP53 mutation and promoter methylation of MIR34A, miR34A-5p is upregulated by 5-aza-2'deoxycytidine. Thus, the TP53/MIR34A "double hit" characterizes a very aggressive subgroup of DLBCL, which may be treatable...

World wide IFC phosphoric acid fuel cell implementation

Energy Technology Data Exchange (ETDEWEB)

King, J.M. Jr

1996-04-01

International Fuel Cells, a subsidary of United technologies Corporation, is engaged in research and development of all types of fuel cell technologies and currently manufactures alkaline fuel cell power plants for the U.S. manned space flight program and natural gas fueled stationary power plants using phosphoric acid fuel cells. This paper describes the phosphoric acid fuel cell power plants.

Photovoltaic Performance Enhancement of Silicon Solar Cells Based on Combined Ratios of Three Species of Europium-Doped Phosphors.

Science.gov (United States)

Ho, Wen-Jeng; You, Bang-Jin; Liu, Jheng-Jie; Bai, Wen-Bin; Syu, Hong-Jhang; Lin, Ching-Fuh

2018-05-18

This paper presents a scheme for the enhancement of silicon solar cells in terms of luminescent emission band and photovoltaic performance. The proposed devices are coated with an luminescent down-shifting (LDS) layer comprising three species of europium (Eu)-doped phosphors mixed within a silicate film (SiO₂) using a spin-on film deposition. The three species of phosphor were mixed at ratios of 0.5:1:1.5, 1:1:1, or 1.5:1:0.5 in weight percentage (wt %). The total quantity of Eu-doped phosphors in the silicate solution was fixed at 3 wt %. The emission wavelengths of the Eu-doped phosphors were as follows: 518 nm (specie-A), 551 nm (specie-B), and 609 nm (specie-C). We examined the extended luminescent emission bands via photoluminescence measurements at room temperature. Closely matching the luminescent emission band to the high responsivity band of the silicon semiconductor resulted in good photovoltaic performance. Impressive improvements in efficiency were observed in all three samples: 0.5:1:1.5 (20.43%), 1:1:1 (19.67%), 1.5:1:0.5 (16.81%), compared to the control with a layer of pure SiO₂ (13.80%).

Initiation in the study of uranium recovery from the phosphoric acid

Energy Technology Data Exchange (ETDEWEB)

Anchondo Adalid, J M

1974-01-01

The loss of considerable amounts of uranium in the Mexican phosphoric acid industry makes it important to study economic methods of recovery; the studies can serve as a basis for the construction and operation of a pilot plant as a normal preliminary to larger-scale projects. Routine experimental techniques for solvent extraction were employed. Extraction efficiencies of the order of 90-95% were obtained using 0.09-0.18M solutions of a mixture of phosphoric octyl esters applied to 4 and 6M solutions of phosphoric acid (reagent grade) containing uranium in concentrations of 0.05-0.50g of U/sub 3/O/sub 8/ per litre of acid. The conclusion was reached that phosphoric octyl esters can be used for recovering uranium in satisfactory quantities from phosphoric acid solutions by means of solvent extraction, and that the uranium can be separated from the solvent by the established procedures.

Initiation in the study of uranium recovery from the phosphoric acid

International Nuclear Information System (INIS)

Anchondo Adalid, J.M.

1974-01-01

The loss of considerable amounts of uranium in the Mexican phosphoric acid industry makes it important to study economic methods of recovery; the studies can serve as a basis for the construction and operation of a pilot plant as a normal preliminary to larger-scale projects. Routine experimental techniques for solvent extraction were employed. Extraction efficiencies of the order of 90-95% were obtained using 0.09-0.18M solutions of a mixture of phosphoric octyl esters applied to 4 and 6M solutions of phosphoric acid (reagent grade) containing uranium in concentrations of 0.05-0.50g of U 3 O 8 per litre of acid. The conclusion was reached that phosphoric octyl esters can be used for recovering uranium in satisfactory quantities from phosphoric acid solutions by means of solvent extraction, and that the uranium can be separated from the solvent by the established procedures. (author)

Method for the recovery of uranium from a concentrate using pure phosphoric acid

International Nuclear Information System (INIS)

1980-01-01

Procedure for the recovery of an uranium bearing concentrate and pure phosphoric acid from a wet process phosphoric acid from the treatment fluid with a precipitation means in conjunction with an organic diluent, the thus formed precipitate to separate and from the remaining mixture of phosphoric acid and diluent the phosphoric acid to extract, characterised in that one applies an inorganic fluorine compound. (G.C.)

Phosphates and phosphoric acid

Energy Technology Data Exchange (ETDEWEB)

Becker, P [Compagnie Francaise de l' Azote, Paris (France)

1983-01-01

In chapter 8.5 the following aspects of uranium recovery are treated: basis of extraction process, extraction principle, solvents, strength of the acid to be treated, technology, main processes in use, impact of uranium recovery on phosphoric acid plants, and economics of uranium recovery plants.

Clinical performance evaluation of total protein measurement by digital refractometry and characterization of non-protein solute interferences

Directory of Open Access Journals (Sweden)

Joshua J.H. Hunsaker

2016-12-01

Full Text Available Objectives: Refractometric methods to measure total protein (TP in serum and plasma specimens have been replaced by automated biuret methods in virtually all routine clinical testing. A subset of laboratories, however, still report using refractometry to measure TP in conjunction with serum protein electrophoresis. The objective of this study was therefore to conduct a modern performance evaluation of a digital refractometer for TP measurement. Design and methods: Performance evaluation of a MISCO Palm Abbe™ digital refractometer was conducted through device familiarization, carryover, precision, accuracy, linearity, analytical sensitivity, analytical specificity, and reference interval verification. Comparison assays included a manual refractometer and an automated biuret assay. Results: Carryover risk was eliminated using a demineralized distilled water (ddH2O wash step. Precision studies demonstrated overall imprecision of 2.2% CV (low TP pool and 0.5% CV (high TP pool. Accuracy studies demonstrated correlation to both manual refractometry and the biuret method. An overall positive bias (+5.0% was observed versus the biuret method. On average, outlier specimens had an increased triglyceride concentration. Linearity was verified using mixed dilutions of: a low and high concentration patient pools, or b albumin-spiked ddH2O and high concentration patient pool. Decreased recovery was observed using ddH2O dilutions at low TP concentrations. Significant interference was detected at high concentrations of glucose (>267 mg/dL and triglycerides (>580 mg/dL. Current laboratory reference intervals for TP were verified. Conclusions: Performance characteristics of this digital refractometer were validated in a clinical laboratory setting. Biuret method remains the preferred assay for TP measurement in routine clinical analyses. Keywords: Refractometry, Digital refractometry, Total protein, Biuret, Serum protein electrophoresis, Monoclonal

Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilis.

Science.gov (United States)

Jiang, Chuanhao; Xiao, Jinhong; Xie, Yafeng; Xiao, Yongjian; Wang, Chuan; Kuang, Xingxing; Xu, Man; Li, Ranhui; Zeng, Tiebing; Liu, Shuanquan; Yu, Jian; Zhao, Feijun; Wu, Yimou

2016-02-01

Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum subsp. pallidum, and accurate diagnosis is important for the prevention and treatment of syphilis. Here, to identify appropriate diagnostic antigens for serodiagnosis of syphilis, 6 recombinant proteins were expressed in Escherichia coli and purified, including flagellins (FlaB1 [Tp0868], FlaB2 [Tp0792], and FlaB3 [Tp0870]), Tp0463, Tp0751, and Tp1038. The sensitivities were determined by screening sera from individuals with primary (n=82), secondary (n=115), latent (n=105), and congenital (n=65) syphilis. The specificities were determined by screening sera from uninfected controls (n=30) and potentially cross-reactive infections including Lyme disease (n=30), leptospirosis (n=5), and hepatitis B (n=30). Our data showed that FlaB1, FlaB2, FlaB3, Tp0463, and Tp1038 exhibited higher overall sensitivities and specificities for detecting IgG antibody, with 95.4% and 98.9%, 92.6% and 95.8%, 95.1% and 95.8%, 92.6% and 97.9%, and 95.9% and 98.9%, respectively. In contrast, Tp0751 demonstrated only an overall sensitivity of 39.2%. For comparison, the sensitivity and specificity of Architect Syphilis TP were determined to be 98.1% and 93.7%, respectively. In addition, FlaB1, FlaB2, FlaB3, and Tp0463 demonstrated excellent performance for detecting IgM antibody in primary and congenital syphilis, with sensitivities of 76.8% and 83.1%, 72.0% and 87.7%, 74.4% and 89.2%, and 64.6% and 75.3%, respectively. These results indicate that FlaB1, FlaB2, FlaB3, and Tp0463 could be as novel diagnostic candidates for serodiagnosis of syphilis. Copyright © 2016 Elsevier Inc. All rights reserved.

A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.

Science.gov (United States)

Neuzillet, Yann; Paoletti, Xavier; Ouerhani, Slah; Mongiat-Artus, Pierre; Soliman, Hany; de The, Hugues; Sibony, Mathilde; Denoux, Yves; Molinie, Vincent; Herault, Aurélie; Lepage, May-Linda; Maille, Pascale; Renou, Audrey; Vordos, Dimitri; Abbou, Claude-Clément; Bakkar, Ashraf; Asselain, Bernard; Kourda, Nadia; El Gaaied, Amel; Leroy, Karen; Laplanche, Agnès; Benhamou, Simone; Lebret, Thierry; Allory, Yves; Radvanyi, François

2012-01-01

TP53 and FGFR3 mutations are the most common mutations in bladder cancers. FGFR3 mutations are most frequent in low-grade low-stage tumours, whereas TP53 mutations are most frequent in high-grade high-stage tumours. Several studies have reported FGFR3 and TP53 mutations to be mutually exclusive events, whereas others have reported them to be independent. We carried out a meta-analysis of published findings for FGFR3 and TP53 mutations in bladder cancer (535 tumours, 6 publications) and additional unpublished data for 382 tumours. TP53 and FGFR3 mutations were not independent events for all tumours considered together (OR = 0.25 [0.18-0.37], p = 0.0001) or for pT1 tumours alone (OR = 0.47 [0.28-0.79], p = 0.0009). However, if the analysis was restricted to pTa tumours or to muscle-invasive tumours alone, FGFR3 and TP53 mutations were independent events (OR = 0.56 [0.23-1.36] (p = 0.12) and OR = 0.99 [0.37-2.7] (p = 0.35), respectively). After stratification of the tumours by stage and grade, no dependence was detected in the five tumour groups considered (pTaG1 and pTaG2 together, pTaG3, pT1G2, pT1G3, pT2-4). These differences in findings can be attributed to the putative existence of two different pathways of tumour progression in bladder cancer: the CIS pathway, in which FGFR3 mutations are rare, and the Ta pathway, in which FGFR3 mutations are frequent. TP53 mutations occur at the earliest stage of the CIS pathway, whereas they occur would much later in the Ta pathway, at the T1G3 or muscle-invasive stage.

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.

Science.gov (United States)

Seillier, Marion; Pouyet, Laurent; N'Guessan, Prudence; Nollet, Marie; Capo, Florence; Guillaumond, Fabienne; Peyta, Laure; Dumas, Jean-François; Varrault, Annie; Bertrand, Gyslaine; Bonnafous, Stéphanie; Tran, Albert; Meur, Gargi; Marchetti, Piero; Ravier, Magalie A; Dalle, Stéphane; Gual, Philippe; Muller, Dany; Rutter, Guy A; Servais, Stéphane; Iovanna, Juan L; Carrier, Alice

2015-06-01

The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors. A genome-wide association study (GWAS) published in 2010 identified TP53INP1 as a new T2D susceptibility locus, but a pathological mechanism was not identified. In this work, we show that mice lacking TP53INP1 are prone to redox-driven obesity and insulin resistance. Furthermore, we demonstrate that the reactive oxygen species increase in TP53INP1-deficient cells results from accumulation of defective mitochondria associated with impaired PINK/PARKIN mitophagy. This chronic oxidative stress also favors accumulation of lipid droplets. Taken together, our data provide evidence that the GWAS-identified TP53INP1 gene prevents metabolic syndrome, through a mechanism involving prevention of oxidative stress by mitochondrial homeostasis regulation. In conclusion, this study highlights TP53INP1 as a molecular regulator of redox-driven metabolic syndrome and provides a new preclinical mouse model for metabolic syndrome clinical research. © 2015 The Authors. Published under the terms of the CC BY 4.0 license.

Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions

International Nuclear Information System (INIS)

Jeong, Young-Il; Kim, Seung Hyun; Ju, Jung Won; Cho, Shin Hyeong; Lee, Won Ja; Park, Jin Wook; Park, Yeong-Min; Lee, Sang Eun

2011-01-01

Highlights: → Treatment with Clonorchis sinensis-derived total protein attenuates OVA-induced airway inflammation and AHR to methacholine. → Induction of CD4 + CD25 + Foxp3 + T cells and IL-10 along with suppression of splenocyte proliferation by C. sinensis-derived total protein. → C. sinensis-derived total protein interferes with the expression of co-stimulatory molecules in DCs. -- Abstract: Asthma is characterized by Th2-mediated inflammation, resulting in airway hyperresponsiveness (AHR) through airway remodeling. Recent epidemiological and experimental reports have suggested an inverse relationship between the development of allergy and helminth infections. Infection by Clonorchis sinensis, a liver fluke that resides in the bile duct of humans, is endemic predominantly in Asia including Korea and China. Using a murine model for asthma, we investigated the effects of C. sinensis-derived total protein (Cs-TP) on allergen-induced airway inflammation and the mechanism underlying the protective effects of Cs-TP administration on asthma. Treatment with Cs-TP attenuated OVA-induced airway inflammation and methacholine-induced AHR, as well as eosinophilia development, lymphocyte infiltration into the lung, and goblet cell metaplasia. This protective effect of Cs-TP is associated with markedly reduced OVA-specific IgE and Th1/Th2 cytokine production. Moreover, Cs-TP increased the number of CD4 + CD25 + Foxp3 + regulatory T (Treg) cells as well as their suppressive activity. In fact, proliferation of OVA-restimulated splenocytes was suppressed significantly. Cs-TP also inhibited the expression of such co-stimulatory molecules as CD80, CD86, and CD40 in LPS- or OVA-stimulated dendritic cells (DCs), suggesting that Cs-TP could interfere with the capacity of airway DCs to prime naive T cells. These data demonstrate the capacity of C. sinensis to ameliorate allergic asthma and broaden our understanding of the paradoxical relationship between the allergic immune

Long term steam oxidation of TP 347H FG in power plants

DEFF Research Database (Denmark)

Hansson, Anette Nørgaard; Korcakova, Leona; Hald, John

2005-01-01

The long term oxidation behaviour of TP 347H FG at ultra supercritical steam conditions was assessed by exposing the steel in test superheater loops in a Danish coal-fired power plant. The steamside oxide layer was investigated with scanning electron microscopy and energy dispersive Xray diffract......The long term oxidation behaviour of TP 347H FG at ultra supercritical steam conditions was assessed by exposing the steel in test superheater loops in a Danish coal-fired power plant. The steamside oxide layer was investigated with scanning electron microscopy and energy dispersive Xray...

UARS Particle Environment Monitor (PEM) Level 3TP V001

Data.gov (United States)

National Aeronautics and Space Administration — The Particle Environment Monitor (PEM) Level 3TP data product consists of daily, 65.536 second and 2.048 interval time-ordered, vertical profiles of electron and...

TL dosimetric characterization of gamma irradiated SrSO{sub 4}:Eu phosphors

Energy Technology Data Exchange (ETDEWEB)

Jayasudha, S., E-mail: jsnair.india@gmail.com [Mahatma Gandhi College, Kesavadasapuram, Pattom Palace P.O., Thiruvananthapuram 695004 (India); Madhukumar, K.; Nair, C.M.K.; Nair, Resmi G. [Mahatma Gandhi College, Kesavadasapuram, Pattom Palace P.O., Thiruvananthapuram 695004 (India); Rajesh, S. [Department of Materials & Ceramic Engineering, University of Aveiro, Aveiro 3810-193 (Portugal); Elias, T.S. [State Institute of Cancer Research, Medical College P.O., Thiruvananthapuram 695011 (India); Anandakumar, V.M. [Mahatma Gandhi College, Kesavadasapuram, Pattom Palace P.O., Thiruvananthapuram 695004 (India); State Institute of Cancer Research, Medical College P.O., Thiruvananthapuram 695011 (India); Department of Materials & Ceramic Engineering, University of Aveiro, Aveiro 3810-193 (Portugal); Gopakumar, N. [Mahatma Gandhi College, Kesavadasapuram, Pattom Palace P.O., Thiruvananthapuram 695004 (India)

2017-03-15

Thermoluminescence (TL) characteristics of SrSO{sub 4}:Eu nanostructured phosphor under gamma excitation has been studied and their suitability for environmental radiation dosimetry applications is discussed. The dopant level is tuned for optimum TL response. The effect of radiation dose and heating rate were investigated. The phosphor preserves linearity in the low dose region, 0.1 Gy to 20 Gy. PL studies of irradiated and un-irradiated phosphors reveal that the dopant Eu exists in divalent state and are the luminescence emission centres in the material. The fading properties of SrSO{sub 4}:Eu phosphor are observed to be better than that of the commercial dosimeters TLD-200 and TLD-400. The kinetic parameters are calculated using Chen's method and initial rise method and verified by Computerized Glow curve Deconvolution (CGCD). The sensitivity of the synthesized phosphor is found to be very high when compared with that of the commercial standard dosimeter CaSO{sub 4}:Dy. The phosphor is found to be stable for short term radiation monitoring.

A novel KMgPO{sub 4}:Tb{sup 3+}(KMPT) phosphor for radiation dosimetry

Energy Technology Data Exchange (ETDEWEB)

Palan, C.B., E-mail: chetanpalan27@gmail.com [Department of Physics, Sant Gadge Baba Amravati University, Amravati 44602 (India); Bajaj, N.S. [Department of Physics, Toshniwal ACS College, Sengaon, Hingoli 431542 (India); Soni, A. [Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400094 (India); Omanwar, S.K. [Department of Physics, Sant Gadge Baba Amravati University, Amravati 44602 (India)

2016-08-15

The polycrystalline sample of KMgPO{sub 4}:Tb{sup 3+}(KMPT) phosphor was successfully synthesized by using solid state method. The X-ray powder diffraction, photoluminescence (PL) emission and excitation spectra, thermoluminescence (TL) and optically stimulated luminescence (OSL) were thoroughly measured. The PL spectra of as-prepared KMPT phosphor showed characteristic blue-green emission, when excited by 226 nm under UV excitation. The optimum PL intensity was observed at 0.01 mol concentration of Tb{sup 3+}ions and this phosphor used for remaining studies. The TL glow curve of KMPT phosphor consist two characterized peaks, which were deconvoluted and the kinetic parameters i.e. trap depth or activation energy, order of kinetic and frequency factor determined by using peak shape method. TL sensitivity of KMPT phosphors was found to be 10% than that of TL sensitivity of TLD-500 phosphor. The OSL sensitivity of KMPT was 0.92 times than OSL sensitivity of α-Al{sub 2}O{sub 3}:C phosphor. The OSL decay curve KMPT phosphor consist of three component having photoionization cross sections were found to be 0.26548×10{sup −17}, 0.220×10{sup −17}, 2.92×10{sup −17} cm{sup 2}. The KMPT phosphor showed linear dose response in range 100–6000 mGy and fading of KMPT phosphor was found to be 31% in 15 days. The Minimum detectable dose (MDD) was found to be 0.39 mGy with corresponding 3σ back ground. The phosphor shows good dosimetry properties such as sensitivity, dose response, MDD, Fading.

Pemetaan Pusat Pelayanan Terpadu Pemberdayaan Perempuan dan Anak (P2TP2A Provinsi Sumatera Bar

Directory of Open Access Journals (Sweden)

Hallen Abu Bakar

2017-09-01

Full Text Available The Center of Integrated Service for Women and Children Empowerment (P2TP2A is established by the government based community in order to eliminate the violence towards women and children. It also aims to empower the position of women and children. The purpose of the study is to describe comprehensively the existance of P2TP2A in sub-district, district, city, and province in West Sumatra. Descriptive qualitative research was used where the data taken from questionnaire and in-deepthinterview. The study found that the Center of Integrated Service for Women and Children Empowerment was established by following certain procedure, legality and personnel structure. It also found that the majority of P2TP2A in West Sumatra has insufficient infrastructures. Meanwhile, it is only P2TP2A Limpapeh Rumah Nan Gadang of West Sumatera, and P2TP2A Luhak Nan Tuo Batusangkar has sufficient infrastructures. Many of them were located at the corner of Community Empowerment and Women and Family Planning office (BPMPKB. Every P2TP2A in those district and city have made their programs, but they faced some difficulties in realize them doe to financial problems. The human resources were recruited from SKPD, academician, professional, society figures, LSM who concern on gender meanstreaming. They play the role more on providing the service than giving information and empowerment. The last finding of the study showed that the involvement of local government, Health offices, social services, police, ministry of religion, prosecutors and social services have been effective.

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

International Nuclear Information System (INIS)

Assumpção, Juliana G; Zeferino, Luiz Carlos; Dufloth, Rozany M; Brandalise, Silvia Regina; Yunes, José Andres; Seidinger, Ana Luíza; Mastellaro, Maria José; Ribeiro, Raul C; Zambetti, Gerard P; Ganti, Ramapriya; Srivastava, Kumar; Shurtleff, Sheila; Pei, Deqing

2008-01-01

The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not associated with Li-Fraumeni syndrome. However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context. We conducted a case-control study to determine the prevalence of the R337H mutation by sequencing TP53 exon 10 in 123 women with breast cancer and 223 age- and sex-matched control subjects from southern Brazil. Fisher's test was used to compare the prevalence of the R337H. The R337H mutation was found in three patients but in none of the controls (p = 0.0442). Among the carriers, two had familial history of cancer meeting the Li-Fraumeni-like criteria. Remarkably, tumors in each of these three cases underwent loss of heterozygosity by eliminating the mutant TP53 allele rather than the wild-type allele. Polymorphisms were identified within the TP53 (R72P and Ins16) and MDM2 (SNP309) genes that may further diminish TP53 tumor suppressor activity. These results demonstrate that the R337H mutation can significantly increase the risk of breast cancer in carriers, which likely depends on additional cooperating genetic factors. These findings are also important for understanding how low-penetrant mutant TP53 alleles can differentially influence tumor susceptibility

TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli

Science.gov (United States)

Munne, Pauliina M.; Gu, Yuexi; Tumiati, Manuela; Gao, Ping; Koopal, Sonja; Uusivirta, Sanna; Sawicki, Janet; Wei, Gong-Hong; Kuznetsov, Sergey G.

2014-04-01

Multiple observations suggest a cell type-specific role for TP53 in mammary epithelia. We developed an in vitro assay, in which primary mouse mammary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of Krt18 or ΔNp63, respectively. Such transition was markedly delayed in Trp53-/- mMECs suggesting that Trp53 is required for specification of the basal, but not lumenal cells. Evidence from human basal-like cell lines suggests that TP53 may support the activity of ΔNp63 by preventing its translocation from nucleoplasm into nucleoli. In human lumenal cells, activation of TP53 by inhibiting MDM2 or BRCA1 restored the nucleoplasmic expression of ΔNp63. Trp53-/- mMECs eventually lost epithelial features resulting in upregulation of MDM2 and translocation of ΔNp63 into nucleoli. We propose that TP63 may contribute to TP53-mediated oncogenic transformation of epithelial cells and shed light on tissue- and cell type-specific biases observed for TP53-related cancers.

Microstructure and properties of TP2 copper tube with La microalloying by horizontal continuous casting

Directory of Open Access Journals (Sweden)

Jin-hu Wu

2018-01-01

Full Text Available The TP2 copper tube was prepared with La microalloying by horizontal continuous casting (HCC. The absorptivity of La and its effects on microstructure, tensile and corrosion properties of HCC TP2 copper tube were studied by means of the inductively coupled plasma optical emission spectrometer (ICP-OES, optical microscope (OM, scanning electron microscope (SEM and potentiodynamic polarization measurements. The results show that the absorptivity of La in the HCC TP2 copper tube is about 15% under antivacuum conditions due to the good chemical activities of La. The impurity elements in copper tube such as O, S, Pb and Si can be significantly reduced, and the average columnar dendrite spacing of the copper tube can also be reduced from 2.21 mm to 0.93 mm by adding La. The ultimate tensile strength and the elongation with and without La addition are almost unchanged. However, the annual corrosion rate of the HCC TP2 copper tube is reduced from 10.18 mm•a-1 to 9.37 mm•a-1 by the purification effect of trace La.

Thermoluminescence dosimetric characteristics of thulium doped ZnB2O4 phosphor

International Nuclear Information System (INIS)

Annalakshmi, O.; Jose, M.T.; Madhusoodanan, U.; Subramanian, J.; Venkatraman, B.; Amarendra, G.; Mandal, A.B.

2014-01-01

Polycrystalline powder samples of rare earth doped Zinc borates were synthesized by high temperature solid state diffusion technique. Dosimetric characteristics of the phosphor like thermoluminescence glow curve, TL emission spectra, dose–response, fading studies, reproducibility and reusability studies were carried out on the synthesized phosphors. Among the different rare earth doped phosphors, thulium doped zinc borate was found to have a higher sensitivity. Hence detailed dosimetric characteristics of this phosphor were carried out. It is observed that the dose–response is linear from 10 mGy to 10 3 Gy in this phosphor. EPR measurements were carried out on unirradiated, gamma irradiated and annealed phosphors to identify the defect centers responsible for thermoluminescence. A TL model is proposed based on the EPR studies in these materials. Kinetic parameters were evaluated for the dosimetric peaks using various methods. The experimental results show that this phosphor can have potential applications in radiation dosimetry applications. -- Highlights: • Polycrystalline powder samples of rare earth doped zinc borates were synthesized. • Thulium was observed to be the most efficient dopant in ZnB 2 O 4 lattice. • TL intensity of the dosimetric peak is around 20 times that of TLD-100. • Based on EPR studies a TL mechanism is proposed in zinc borate. • Deconvolution of the glow curve carried out

Phosphor plate mammography: contrast studies and clinical experience

International Nuclear Information System (INIS)

Chang, C.H.J.; Martin, N.L.; Templeton, A.W.; Cook, L.T.; Harrison, L.A.; McFadden, M.A.; Dwyer, S.J. III; Spicer, J.; Crystal, J.M.

1992-01-01

Mammography and accurate microcalcification detection require very good spatial resolution. We have compared the diagnostic capabilities of reduced-exposure, third-generation, 5 cycles/mm computed radiography (CR) phosphor plates with conventional screen-film in 67 patients. No difference in diagnostic accuracy was detected. The digital characteristics of storage phosphor plates erabled us to study the relationship between contrast and spatial resolution. We developed a computer program to identify a single 100 μm pixel in a digital image and assign various gray levels to that pixel. Using this model, we determined that, for our 5 cycles/mm CR system, the imaged contrast of a 100 μm object was 62% of the original contrast. Current 5 cycles/mm phosphor plate systems cannot adequately detect microcalcifications that approximate 100 μm or smaller unless a magnification technique is used. (orig.)

Persistent phosphors for painting, medical and biological applications

International Nuclear Information System (INIS)

Nazarov, M.

2013-01-01

Multiphase micro and nanoparticle persistent phosphors are synthesized and applied for different fields including painting, medical and biological investigations. A lot of examples show a broad range of applications of persistent luminescence from bulk materials to high tech products, especially in medicine. The development of high efficiency nanosized phosphor makes it possible to propose persistent materials as very good candidates for photodynamic therapy of cancer. An artificial block from slag, concrete, and sand covered with SrAl 2 O 4 :Eu 2+ , Dy 3+ based phosphor is prepared, and a new direction in biology for algae cultivation and artificial reef is discussed. For the first time, underwater luminescence is experimentally studied under real sea conditions. Bright blue-green long-lasting afterglow is registered at a depth of 5 m. The fishes are attracted by the light of the artificial reef. (author)

Measurement of thermal neutron fluence with CaSO4 thermoluminescent phosphors

International Nuclear Information System (INIS)

Liu Jinhua; Su Jingling; Wei Zemin

1984-01-01

During neutron irradiation, some TL phosphors were activated. After leaving the irradiation field the TL phosphor produced self-irradiation. The TL output of self-dose was only related to the original neutron fluence and independent of the γ-radiation. Several CaSO 4 TL phosphors were made. They were CaSO 4 :Dy, CaSO 4 :Dy-Teflon, CaSO 4 :Dy mixed with Dy 2 O 3 , CaSO 4 :Mn mixed with Dy 2 O 3 . The linearity, and lower detection limits of these TL phosphors were measured. The thermal neutron response of CaSO 4 :Mn mixed with Dy 2 O 3 was 64 R/(10 10 cm -2 ) and the lower detection limit was 1.3x10 5 cm -2

TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.

Science.gov (United States)

Kulasekararaj, Austin G; Smith, Alexander E; Mian, Syed A; Mohamedali, Azim M; Krishnamurthy, Pramila; Lea, Nicholas C; Gäken, Joop; Pennaneach, Coralie; Ireland, Robin; Czepulkowski, Barbara; Pomplun, Sabine; Marsh, Judith C; Mufti, Ghulam J

2013-03-01

This study aimed to determine the incidence/prognostic impact of TP53 mutation in 318 myelodysplastic syndrome (MDS) patients, and to correlate the changes to cytogenetics, single nucleotide polymorphism array karyotyping and clinical outcome. The median age was 65 years (17-89 years) and median follow-up was 45 months [95% confidence interval (CI) 27-62 months]. TP53 mutations occurred in 30 (9.4%) patients, exclusively in isolated del5q (19%) and complex karyotype (CK) with -5/5q-(72%), correlated with International Prognostic Scoring System intermediate-2/high, TP53 protein expression, higher blast count and leukaemic progression. Patients with mutant TP53 had a paucity of mutations in other genes implicated in myeloid malignancies. Median overall survival of patients with TP53 mutation was shorter than wild-type (9 versus 66 months, P disappearance of the mutant clone or emergence of new clones, suggesting an early occurrence of TP53 mutations. A reduction in mutant clone correlated with response to 5-azacitidine, however clones increased in non-responders and persisted at relapse. The adverse impact of TP53 persists after adjustment for cytogenetic risk and is of practical importance in evaluating prognosis. The relatively common occurrence of these mutations in two different prognostic spectrums of MDS, i.e. isolated 5q- and CK with -5/5q-, possibly implies two different mechanistic roles for TP53 protein. © 2013 Crown copyright. This article is published with the permission of the Controller of HMSO and the Queen's Printer for Scotland.

Photovoltaic Performance Enhancement of Silicon Solar Cells Based on Combined Ratios of Three Species of Europium-Doped Phosphors

Directory of Open Access Journals (Sweden)

Wen-Jeng Ho

2018-05-01

Full Text Available This paper presents a scheme for the enhancement of silicon solar cells in terms of luminescent emission band and photovoltaic performance. The proposed devices are coated with an luminescent down-shifting (LDS layer comprising three species of europium (Eu-doped phosphors mixed within a silicate film (SiO2 using a spin-on film deposition. The three species of phosphor were mixed at ratios of 0.5:1:1.5, 1:1:1, or 1.5:1:0.5 in weight percentage (wt %. The total quantity of Eu-doped phosphors in the silicate solution was fixed at 3 wt %. The emission wavelengths of the Eu-doped phosphors were as follows: 518 nm (specie-A, 551 nm (specie-B, and 609 nm (specie-C. We examined the extended luminescent emission bands via photoluminescence measurements at room temperature. Closely matching the luminescent emission band to the high responsivity band of the silicon semiconductor resulted in good photovoltaic performance. Impressive improvements in efficiency were observed in all three samples: 0.5:1:1.5 (20.43%, 1:1:1 (19.67%, 1.5:1:0.5 (16.81%, compared to the control with a layer of pure SiO2 (13.80%.

Remote sensing estimation of the total phosphorus concentration in a large lake using band combinations and regional multivariate statistical modeling techniques.

Science.gov (United States)

Gao, Yongnian; Gao, Junfeng; Yin, Hongbin; Liu, Chuansheng; Xia, Ting; Wang, Jing; Huang, Qi

2015-03-15

Remote sensing has been widely used for ater quality monitoring, but most of these monitoring studies have only focused on a few water quality variables, such as chlorophyll-a, turbidity, and total suspended solids, which have typically been considered optically active variables. Remote sensing presents a challenge in estimating the phosphorus concentration in water. The total phosphorus (TP) in lakes has been estimated from remotely sensed observations, primarily using the simple individual band ratio or their natural logarithm and the statistical regression method based on the field TP data and the spectral reflectance. In this study, we investigated the possibility of establishing a spatial modeling scheme to estimate the TP concentration of a large lake from multi-spectral satellite imagery using band combinations and regional multivariate statistical modeling techniques, and we tested the applicability of the spatial modeling scheme. The results showed that HJ-1A CCD multi-spectral satellite imagery can be used to estimate the TP concentration in a lake. The correlation and regression analysis showed a highly significant positive relationship between the TP concentration and certain remotely sensed combination variables. The proposed modeling scheme had a higher accuracy for the TP concentration estimation in the large lake compared with the traditional individual band ratio method and the whole-lake scale regression-modeling scheme. The TP concentration values showed a clear spatial variability and were high in western Lake Chaohu and relatively low in eastern Lake Chaohu. The northernmost portion, the northeastern coastal zone and the southeastern portion of western Lake Chaohu had the highest TP concentrations, and the other regions had the lowest TP concentration values, except for the coastal zone of eastern Lake Chaohu. These results strongly suggested that the proposed modeling scheme, i.e., the band combinations and the regional multivariate

A novel orange emissive phosphor SrWO4:Sm3+ for white light-emitting diodes

International Nuclear Information System (INIS)

Ju Zhenghua; Wei Ruiping; Ma Jingxin; Pang Chaoran; Liu Weisheng

2010-01-01

Research highlights: → A novel orange emissive phosphor SrWO 4 :Sm 3+ was firstly reported. → The optics properties of Sm 3+ -doped SrWO 4 phosphor were successfully discussed. → The temperature-dependent luminescence indicates the phosphor exhibits a small thermal-quenching property. → The phosphor is a potential candidate as orange-emitting component for white LED. - Abstract: A novel orange emissive phosphor, Sm 3+ -doped SrWO 4 , was synthesized by high temperature solid-state reaction in air atmosphere. The excitation spectra show that the phosphors can be efficiently excited by ultraviolet and near-ultraviolet light, the optimized concentration is 4 mol%. Three emission peaks locate at 562, 596 and 642 nm, corresponding to CIE chromaticity coordinates of (x = 0.54, y = 0.46), which indicates the orange light emitting. The decay curves are well fitted with triple-exponential decay models. The quantum yield of the Sr 0.96 Sm 0.04 WO 4 phosphor is about 70.65% under excitation of 377 nm. Furthermore, the temperature-dependent luminescence indicates the phosphor exhibits a small thermal-quenching property. So the phosphor is able to be applied to UV-LED chip-based white light-emitting diodes.

Method for separating mono- and di-octylphenyl phosphoric acid esters

International Nuclear Information System (INIS)

Arnold, W.D. Jr.

1977-01-01

A method for separating mono-octylphenyl phosphoric acid ester and di-octylphenyl phosphoric acid ester from a mixture thereof comprises reacting the ester mixture with a source of lithium or sodium ions to form a mixture of the phosphate salts; contacting the salt mixture with an organic solvent which causes the dioctylphenyl phosphate salt to be dissolved in the organic solvent phase and the mono-octylphenyl phosphate salt to exist in a solid phase; separating the phases; recovering the phosphate salts from their respective phases; and acidifying the recovered salts to form the original phosphoric acid esters

New recurrent deletions in the PPARgamma and TP53 genes are associated with childhood myelodysplastic syndrome

DEFF Research Database (Denmark)

Silveira, Cássia G T; Oliveira, Fábio M; Valera, Elvis T

2009-01-01

Myelodysplastic syndrome (MDS) is a rare hematological malignancy in children. It was performed FISH analysis in 19 pediatric MDS patients to investigate deletions involving the PPARgamma and TP53 genes. Significant losses in the PPARgamma gene and deletions in the tumor suppressor gene TP53 were...

UV induced thermoluminescence in rare earth oxide doped phosphors: possible use for UV dosimetry

International Nuclear Information System (INIS)

Yeh, S.-M.; Su, C.-S.

1996-01-01

UV induced thermoluminescent (TL) phenomena in some phosphors doped with rare earth oxides (Gd 2 O 3 :Eu, Gd 2 O 3 :Tb, Gd 2 O 3 :Dy and Y 2 O 3 :EU) have been investigated. Gd 2 O 3 :Eu and Y 2 O 3 :Eu have been found to possess prominent TL phenomena. A stable high temperature glow peak has been found at 345 o C in the cubic (C type) crystalline structure of Gd 2 O 3 :Eu. A more stable high temperature glow peak has also been found at about 380 o C in Y 2 O 3 :Eu. The sensitivity is high enough to be used as UV sensors. TL phenomena in Gd 2 O 3 :Tb and Gd 2 O 3 :Dy have also been investigated, but their TL intensities are much weaker than that of Gd 2 O 3 :Eu or Y 2 O 3 :Eu. On the other hand, all glow peaks of Gd 2 O 3 :Tb and Gd 2 O 3 :Dy are unstable at room temperature, therefore, Gd 2 O 3 :Tb and Gd 2 O 3 :Dy are not suitable for use as UV detectors. According to the above properties, the C type (cubic) crystalline structure of the Gd 2 O 3 :Eu phosphor seems to possess the potential of being the TL material for UV measurement. The position of the high temperature glow peak depends on the total UV exposure. It locates at about 380 o C when this phosphor was irradiated by 302 nm UV at 2.4 mJ.cm -2 exposure, but it shifts to 345 o C at 19.2 mJ.cm -2 or higher exposure. The response curves of this phosphor for various wavelengths, e.g. 253.7 nm, 302 nm, and 365 nm, were also measured. This phosphor is sensitive enough to measure background UV radiations, such as sunlight, bulb light etc. (author)

Meta-analysis of association between the TP53 Arg72Pro polymorphism and risk of endometriosis based on case-control studies.

Science.gov (United States)

Yan, Yulan; Wu, Renzheng; Li, Shaojing; He, Jinlong

2015-06-01

In the light of the relationship between the TP53 Arg72Pro (rs1042522) polymorphism and the risk of endometriosis remains inclusive or controversial. For better understanding of the effect of TP53 Arg72Pro polymorphism on endometriosis risk, we performed a meta-analysis. The relevant studies were identified through a search of PubMed, Web of Science, EMBASE, Ovid, Springer, China National Knowledge Infrastructure (CNKI), cqvip, Wanfang database, and Chinese Biomedical Literature (CBM) databases up to December, 2014. The association between the TP53 Arg72Pro polymorphism and endometriosis risk was pooled by conducted by odds ratios and 95% confidence intervals. A total of fifteen case-control studies with 2683 cases and 3335 controls were eventually identified. There was significant association between Arg72Pro polymorphism and endometriosis risk in all of the five models in overall populations (C vs. G: OR=1.32, 95%CI=1.14-1.53, p=0.00; CC vs. GG: OR=1.80, 95%CI=1.28-2.53, p=0.001; GC vs. GG: OR=1.52, 95%CI=1.22-1.88, p=0.00; CC vs. OR=1.32, 95%CI=1.05-1.66, p=0.016; CC/GC vs. GG: OR=1.59, 95%CI=1.26-2.00, p=0.00). In the sub-group analysis according to ethnicity, the results suggested that TP53 Arg72Pro polymorphism was not associated with endometriosis risk in Caucasians. However, the significant association was found in Asians and Mixed race (MIX) under the five models. The results of this meta-analysis suggest that the TP53 Arg72Pro polymorphism can increase the risk of endometriosis, especially among Asians and MIX populations. Considering the limited sample size and ethnicities included in the meta-analysis, further larger scaled and well-designed studies are needed to confirm our results. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A meta-analysis of the relationship between FGFR3 and TP53 mutations in bladder cancer.

Directory of Open Access Journals (Sweden)

Yann Neuzillet

Full Text Available TP53 and FGFR3 mutations are the most common mutations in bladder cancers. FGFR3 mutations are most frequent in low-grade low-stage tumours, whereas TP53 mutations are most frequent in high-grade high-stage tumours. Several studies have reported FGFR3 and TP53 mutations to be mutually exclusive events, whereas others have reported them to be independent. We carried out a meta-analysis of published findings for FGFR3 and TP53 mutations in bladder cancer (535 tumours, 6 publications and additional unpublished data for 382 tumours. TP53 and FGFR3 mutations were not independent events for all tumours considered together (OR = 0.25 [0.18-0.37], p = 0.0001 or for pT1 tumours alone (OR = 0.47 [0.28-0.79], p = 0.0009. However, if the analysis was restricted to pTa tumours or to muscle-invasive tumours alone, FGFR3 and TP53 mutations were independent events (OR = 0.56 [0.23-1.36] (p = 0.12 and OR = 0.99 [0.37-2.7] (p = 0.35, respectively. After stratification of the tumours by stage and grade, no dependence was detected in the five tumour groups considered (pTaG1 and pTaG2 together, pTaG3, pT1G2, pT1G3, pT2-4. These differences in findings can be attributed to the putative existence of two different pathways of tumour progression in bladder cancer: the CIS pathway, in which FGFR3 mutations are rare, and the Ta pathway, in which FGFR3 mutations are frequent. TP53 mutations occur at the earliest stage of the CIS pathway, whereas they occur would much later in the Ta pathway, at the T1G3 or muscle-invasive stage.

Uranium extraction in phosphoric acid

International Nuclear Information System (INIS)

Araujo Figueiredo, C. de

1984-01-01

Uranium is recovered from the phosphoric liquor produced from the concentrate obtained from phosphorus-uraniferous mineral from Itataia mines (CE, Brazil). The proposed process consists of two extraction cycles. In the first one, uranium is reduced to its tetravalent state and then extracted by dioctylpyrophosphoric acid, diluted in Kerosene. Re-extraction is carried out with concentrated phosphoric acid containing an oxidising agent to convert uranium to its hexavalent state. This extract (from the first cycle) is submitted to the second cycle where uranium is extracted with DEPA-TOPO (di-2-hexylphosphoric acid/tri-n-octyl phosphine oxide) in Kerosene. The extract is then washed and uranium is backextracted and precipitated as commercial concentrate. The organic phase is recovered. Results from discontinuous tests were satisfactory, enabling to establish operational conditions for the performance of a continuous test in a micro-pilot plant. (Author) [pt

Agronomic behavior of phosphoric rock from Bahia Inglesa using isotopic techniques. 2. Greenhouse experiment in three volcanic ash soils

International Nuclear Information System (INIS)

Pino N, I.; Casas G, L.

1989-01-01

With the aim to evaluate the behaviour of phosphoric rock in regard to the sorption capacity from three volcanic ash soils, a greenhouse trial was carried out. The isotopic dilution method with triple superphosphate labeled P32 (TSP-32) was used. Total dry matter, P total was determined by colorimetry and the liquid scintillation method for P32 was used. The evaluation of the rock was measured through different isotopical parameters such as A value and P derived from the rock. The behaviour of this material was affected by the different properties of the soils mainly on account of the diverse sorption capacity of them giving an inverse relation among sorption and effectiveness of the rock. The results showed a higher efficiency of TSP for the three soils compared with the phosphoric rock either concentrated or not. (author)

Recovery of zinc in phosphor wastes via electrokinetic treatments

International Nuclear Information System (INIS)

Yu, M.Y.; Wang, H. Paul; Chen, C.Y.; Hsiung, T.-L.; Wei, Yu-Ling; Tai, H.-S.; Chiang, K.-C.

2007-01-01

Speciation of zinc in phosphor wastes during electrokinetic treatments has been studied by in situ X-ray absorption near edge structure (XANES) spectroscopy in the present work. The least-square fits of the in situ XANES spectra show that the major zinc species in the phosphor waste are ZnS (77%), ZnO (10%), and Zn(OH) 2 (13%). During the electrokinetic treatment for 90 min, 25% of ZnS and 4% of ZnO are dissolved. About 42% of zinc is enriched on the cathode under the electric field (5 V/cm). Prolonging the electrokinetic treatment time to 4 h under the electric field of 5 V/cm, at least 80% of zinc in the phosphor waste can be recovered

Quantitative Characterization of Phosphor Detector for Fusion Plasmas

International Nuclear Information System (INIS)

Baciero, A.; Zurro, B.; McCarthy, K. J.

2004-01-01

Experiments made to characterize phosphor screens with application as broadband radiation detectors, are described. Several radiation sources, covering the spectral range between the ultraviolet and X ray, were used. In addition, details are given of three original phosphor-screen-based detectors that were designed for use as broadband detectors in magnetically confined fusion devices. The first measurements obtained with these detectors in plasmas created in the TJ-II stellarator device are presented together with the analysis performed. (Author)

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

Directory of Open Access Journals (Sweden)

Srivastava Kumar

2008-12-01

Full Text Available Abstract Background The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not associated with Li-Fraumeni syndrome. However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context. Methods We conducted a case-control study to determine the prevalence of the R337H mutation by sequencing TP53 exon 10 in 123 women with breast cancer and 223 age- and sex-matched control subjects from southern Brazil. Fisher's test was used to compare the prevalence of the R337H. Results The R337H mutation was found in three patients but in none of the controls (p = 0.0442. Among the carriers, two had familial history of cancer meeting the Li-Fraumeni-like criteria. Remarkably, tumors in each of these three cases underwent loss of heterozygosity by eliminating the mutant TP53 allele rather than the wild-type allele. Polymorphisms were identified within the TP53 (R72P and Ins16 and MDM2 (SNP309 genes that may further diminish TP53 tumor suppressor activity. Conclusion These results demonstrate that the R337H mutation can significantly increase the risk of breast cancer in carriers, which likely depends on additional cooperating genetic factors. These findings are also important for understanding how low-penetrant mutant TP53 alleles can differentially influence tumor susceptibility.

A novel ELISA using a recombinant outer membrane protein, rTp0663, as the antigen for serological diagnosis of syphilis.

Science.gov (United States)

Xu, Man; Xie, Yafeng; Jiang, Chuanhao; Xiao, Yongjian; Kuang, Xingxing; Zhao, Feijun; Zeng, Tiebing; Liu, Shuangquan; Liang, Mingxing; Li, Li; Wang, Chuan; Wu, Yimou

2016-02-01

The lack of Treponema pallidum-specific antigens with highly accurate diagnosis makes the diagnosis of syphilis challenging. A soluble recombinant version of a new diagnostic protein Tp0663 has been produced. The serodiagnostic potential of this protein was assessed by screening 3326 serum samples simultaneously evaluated by rapid plasma reagin and T. pallidum particle agglutination tests. Kappa (κ) coefficients were used to compare the concordance between clinical diagnosis and the Tp0663-based ELISA or the ARCHITECT Syphilis TP chemiluminescent immunoassay (Abbott GmbH and Co. KG). Using the results of clinical diagnosis as the gold standard, the sensitivity and specificity of Tp0663 were found to be 98.83% (95% confidence interval (CI) 96.61-99.60%) and 100% (95% CI 99.88-100%), respectively. In comparison, the ARCHITECT Syphilis TP assay was found to have a lower sensitivity (97.27%, 95% CI 94.46-98.67%) and specificity (99.61%, 95% CI 99.32-99.78%). In particular, the ARCHITECT Syphilis TP exhibited a false-positive rate of 0.39%. Moreover, the ELISA was in perfect agreement with the gold standard, with a κ value of 0.99, comparable to that of ARCHITECT Syphilis TP (0.96). These results identified Tp0663 as a novel serodiagnostic candidate with great potential for developing novel tests for the diagnosis of syphilis. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Electroluminescent efficiency of alternating current thick film devices using ZnS:Cu,Cl phosphor

International Nuclear Information System (INIS)

Sharma, Gaytri; Han, Sang Do; Kim, Jung Duk; Khatkar, Satyender P.; Rhee, Young Woo

2006-01-01

ZnS:Cu,Cl phosphor is prepared with the help of low intensity milling of the precursor material in two step firing process. The synthesized phosphor is used for the preparation of alternating current thick film electroluminescent (ACTFEL) devices with screen-printing method. The commission international de l'Eclairge (CIE) color co-ordinates of the ACTFEL devices prepared by these phosphor layers shows a shift from bluish-green to green region with the change in the amount of Cu in the phosphor. The various parameters to improve the efficiency and luminance of the devices have also been investigated. The brightness of the ac thick film EL device depends on the particle size of the phosphor, crystallinity, amount of binding material and applied voltage. The EL device fabricated with phosphor having average particle size of 25 μm shows maximum luminescence, when 60% phosphor concentration is used with respect to binding material. EL intensity is also linearly dependent on frequency. It is due the increase of excitation chances of the host matrix or dopant ions with increasing frequency

High-efficient, bicolor-emitting GdVO_4:Dy"3"+ phosphor under near ultraviolet excitation

International Nuclear Information System (INIS)

Lu, Jinjin; Zhou, Jia; Jia, Huayu; Tian, Yue

2015-01-01

Bicolor emitting GdVO_4:Dy"3"+ phosphor with short columniation-shape was prepared via a simple co-precipitation process. The optimal doping concentration for obtaining maximal luminescent intensity was confirmed to be 0.3 mol% and the electric dipole–dipole interaction is responsible for concentration quenching of Dy"3"+ emission in GdVO_4 phosphor. In order to evaluate the luminescent performance of as-prepared phosphor, the luminescent efficiency and color coordinates were studied. The results show that luminescent efficiency of this phosphor is very high under near UV excitation and twice times higher than commercial Y_2O_2S:Eu"3"+ phosphor. In addition, the color coordinates for optimal Dy"3"+ concentration are (0.339, 0.379), which are close to equal energy point. Therefore, the GdVO_4:Dy"3"+ phosphor may have potential application for solid state lighting.

TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

International Nuclear Information System (INIS)

Giacomazzi, Juliana; Hainaut, Pierre; Ashton-Prolla, Patricia; Selistre, Simone; Duarte, Juliana; Ribeiro, Jorge Pinto; Vieira, Paulo JC; Souza Macedo, Gabriel de; Rossi, Cristina; Czepielewski, Mauro; Netto, Cristina Brinkmann Oliveira

2013-01-01

Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. In Brazil, a particular mutation, occurring in the tetramerisation domain of the gene, p.R337H, is exceedingly common due to a founder effect and is strongly associated with ACC. In this report, we describe the phenotype and long-term clinical follow-up of a female child diagnosed with ACC and homozygous for the TP53 p.R337H founder mutation. At age 11 months, the patient was diagnosed with a virilising anaplastic adrenal cortical tumour, which was completely excised without disturbing the adrenal capsule. Family history was consistent with an LFL tumour pattern, and genotyping identified the TP53 p.R337H mutation in both alleles in genomic DNA from lymphocytes and fibroblasts. Haplotype analysis confirmed the occurrence of the mutation in the same founder haplotype previously described in other Brazilian patients. No other germline or somatic TP53 mutations or rearrangements were identified. At age 9 years, the child was asymptomatic and had no evidence of endocrine derangements. Full body and brain magnetic resonance imaging (MRI) failed to detect any suspicious proliferative lesions, and cardiopulmonary exercise testing results were within the normal reference for the child’s age, ruling out a major exercise capacity deficiency. This is the first clinical and aerobic functional capacity documentation of a patient who carries two mutant TP53 alleles and no wild-type allele. Our results support the hypothesis that TP53 p.R337H, the most common TP53 mutation ever described in any population, is a conditional mutant. Furthermore, our observations over a long period of clinical follow-up suggest that TP53 p.R337H homozygotes do not have a more severe disease phenotype than do heterozygote carriers of the same mutation. Patients with

Mutational analysis of the activator of late transcription, Alt , in the lactococcal bacteriophage TP901-1

DEFF Research Database (Denmark)

Pedersen, Margit; Hammer, Karin

2007-01-01

An activator protein, Alt, synthesized during the early state of lytic infection is required for transcription of the late operon in the lactococcal phage TP901-1. In order to identify amino acid residues in the Alt protein required for activation of the TP901-1 late promoter, Plate, hydroxylamine...

Clinical Impact of TP53 Gene Mutations in Diffuse Large B-Cell Lymphoma (DLBCL)

DEFF Research Database (Denmark)

Young, Ken H; Patten, Nancy; Truong, Sim

2009-01-01

Mutations of the TP53 tumor suppressor gene are associated with a poor clinical outcome in DLBCL patients treated with CHOP. The impact of TP53 mutations on clinical outcome of DLBCL patients treated with Rituxan-CHOP has not been comprehensively analyzed. The purpose of this study was to analyze...

Influencia de la soldadura sobre la rotura por tensiones en tubos de acero inoxidable austenitico del tipo 18-11NB(TP347

Directory of Open Access Journals (Sweden)

Gutiérrez de Saiz-Solabarria, S.

2000-06-01

Full Text Available This work has been undertaken to study the stress cracking failure in various 18Cr11Ni [TP347 (18-11Nb, TP 321 (18-11 Ti, TP304 (18-11 and TP316 (18-11-2] types austenitic stainless steel tubes. The material used was produced hot-rolling at 76,2 mm φ (3"φ x 2,54 mm (1/10" thickness. The study was carried out at 593ºC and applied stress of 50 Ton/in2.

Se estudia el efecto de la soldadura sobre la rotura por tensiones en tubos de acero inoxidable austenítico estabilizado con Nb o Ti de los tipos 18-11Nb (TP 347 y 18-11Ti (TP 321 así como sin estabilizar del tipo 18-11 (TP 304 y con Mo del tipo 18-11-2 (TP 316. Los tubos, en todos los casos, son de dimensiones 76,2 mm (3” φ x 2,54 mm (1/10” de espesor y la tensión aplicada (σ de 10 Ton/in2, para una temperatura de servicio de 593ºC.

License - TP Atlas | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ... might be changed without notice. About This Database Database Description Download License Update History of This Database Site Policy | Contact Us License - TP Atlas | LSDB Archive ...

A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography

Energy Technology Data Exchange (ETDEWEB)

Berg, Eric, E-mail: eberg@ucdavis.edu; Roncali, Emilie; Du, Junwei; Cherry, Simon R. [Department of Biomedical Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616 (United States); Kapusta, Maciej [Molecular Imaging, Siemens Healthcare, Knoxville, Tennessee 37932 (United States)

2016-02-15

Purpose: In support of a project to build a total-body PET scanner with an axial field-of-view of 2 m, the authors are developing simple, cost-effective block detectors with combined time-of-flight (TOF) and depth-of-interaction (DOI) capabilities. Methods: This work focuses on investigating the potential of phosphor-coated crystals with conventional PMT-based block detector readout to provide DOI information while preserving timing resolution. The authors explored a variety of phosphor-coating configurations with single crystals and crystal arrays. Several pulse shape discrimination techniques were investigated, including decay time, delayed charge integration (DCI), and average signal shapes. Results: Pulse shape discrimination based on DCI provided the lowest DOI positioning error: 2 mm DOI positioning error was obtained with single phosphor-coated crystals while 3–3.5 mm DOI error was measured with the block detector module. Minimal timing resolution degradation was observed with single phosphor-coated crystals compared to uncoated crystals, and a timing resolution of 442 ps was obtained with phosphor-coated crystals in the block detector compared to 404 ps without phosphor coating. Flood maps showed a slight degradation in crystal resolvability with phosphor-coated crystals; however, all crystals could be resolved. Energy resolution was degraded by 3%–7% with phosphor-coated crystals compared to uncoated crystals. Conclusions: These results demonstrate the feasibility of obtaining TOF–DOI capabilities with simple block detector readout using phosphor-coated crystals.

A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography

International Nuclear Information System (INIS)

Berg, Eric; Roncali, Emilie; Du, Junwei; Cherry, Simon R.; Kapusta, Maciej

2016-01-01

Purpose: In support of a project to build a total-body PET scanner with an axial field-of-view of 2 m, the authors are developing simple, cost-effective block detectors with combined time-of-flight (TOF) and depth-of-interaction (DOI) capabilities. Methods: This work focuses on investigating the potential of phosphor-coated crystals with conventional PMT-based block detector readout to provide DOI information while preserving timing resolution. The authors explored a variety of phosphor-coating configurations with single crystals and crystal arrays. Several pulse shape discrimination techniques were investigated, including decay time, delayed charge integration (DCI), and average signal shapes. Results: Pulse shape discrimination based on DCI provided the lowest DOI positioning error: 2 mm DOI positioning error was obtained with single phosphor-coated crystals while 3–3.5 mm DOI error was measured with the block detector module. Minimal timing resolution degradation was observed with single phosphor-coated crystals compared to uncoated crystals, and a timing resolution of 442 ps was obtained with phosphor-coated crystals in the block detector compared to 404 ps without phosphor coating. Flood maps showed a slight degradation in crystal resolvability with phosphor-coated crystals; however, all crystals could be resolved. Energy resolution was degraded by 3%–7% with phosphor-coated crystals compared to uncoated crystals. Conclusions: These results demonstrate the feasibility of obtaining TOF–DOI capabilities with simple block detector readout using phosphor-coated crystals

Promotion of Crystal Growth on Biomass-based Carbon using Phosphoric Acid Treatments

Directory of Open Access Journals (Sweden)

Liwei Yu

2015-02-01

Full Text Available The effect of phosphoric acid treatments on graphitic microcrystal growth of biomass-based carbons was investigated using X-ray diffraction, infrared spectroscopy, and Raman spectroscopy. Although biomass-based carbons are believed to be hard to graphitize even after heat treatments well beyond 2000 °C, we found that graphitic microcrystals of biomass-based carbons were significantly promoted by phosphoric acid treatments above 800 °C. Moreover, twisted spindle-like whiskers were formed on the surface of the carbons. This suggests that phosphorus-containing groups turn graphitic microcrystalline domains into graphite during phosphoric acid treatments. In addition, the porous texture of the phosphoric acid-treated carbon has the advantage of micropore development.

Phosphors for near UV-Emitting LED's for Efficacious Generation of White Light

Energy Technology Data Exchange (ETDEWEB)

McKittrick, Joanna [Univ. of California, San Diego, CA (United States)

2013-09-30

1) We studied phosphors for near-UV (nUV) LED application as an alternative to blue LEDs currently being used in SSL systems. We have shown that nUV light sources could be very efficient at high current and will have significantly less binning at both the chip and phosphor levels. We identified phosphor blends that could yield 4100K lamps with a CRI of approximately 80 and LPWnUV,opt equal to 179 for the best performing phosphor blend. Considering the fact that the lamps were not optimized for light coupling, the results are quite impressive. The main bottleneck is an optimum blue phosphor with a peak near 440 nm with a full width half maximum of about 25 nm and a quantum efficiency of >95%. Unfortunately, that may be a very difficult task when we want to excite a phosphor at ~400 nm with a very small margin for Stokes shift. Another way is to have all the phosphors in the blend having the excitation peak at 400 nm or slightly shorter wavelength. This could lead to a white light source with no body color and optimum efficacy due to no self-absorption effects by phosphors in the blend. This is even harder than finding an ideal blue phosphor, but not necessarily impossible. 2) With the phosphor blends identified, light sources using nUV LEDs at high current could be designed with comparable efficacy to those using blue LEDs. It will allow us to design light sources with multiple wattages using the same chips and phosphor blends simply by varying the input current. In the case of blue LEDs, this is not currently possible because varying the current will lower the efficacy at high current and alter the color point. With improvement of phosphor blends, control over CRI could improve. Less binning at the chip level and also at the phosphor blend level could reduce the cost of SSL light sources. 3) This study provided a deeper understanding of phosphor characteristics needed for LEDs in general and nUV LEDs in particular. Two students received Ph.D. degrees and three

FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities

International Nuclear Information System (INIS)

L’Abbate, Alberto; Tagliafico, Enrico; Minoia, Carla; De Tullio, Giacoma; Guarini, Attilio; Testoni, Nicoletta; Agostinelli, Claudio; Storlazzi, Clelia Tiziana; Lo Cunsolo, Crocifissa; Macrì, Ettore; Iuzzolino, Paolo; Mecucci, Cristina; Doglioni, Claudio; Coco, Michelina; Muscarella, Lucia Anna; Salati, Simona

2014-01-01

The progression of low-risk del(5q) myelodysplastic syndrome to acute myeloid leukemia is increased when associated with mutations of TP53, or with additional chromosomal abnormalities. However, to date the prognostic impact and molecular consequences of these rearrangements were poorly investigated. Single additional alterations to del(5q) by balanced chromosome rearrangements were rarely found in myelodysplasia. In particular, balanced alterations involving TP63 and FOXP1 genes were never reported in the literature. Here we report on a 79-year woman with an aggressive form of myelodysplastic syndrome with del(5q), no TP53 mutation, and a novel complex rearrangement of chromosome 3 in bone marrow cells. Our results revealed that the FOXP1 and TP63 genes were both relocated along chromosome 3. Strikingly, immunohistochemistry analysis showed altered protein levels, disclosing that this rearrangement triggered the expression of FOXP1 and TP63 genes. FOXP1 was also found activated in other patients with myelodysplasia and acute myeloid leukemia, showing that it is an important, recurrent event. We document an apparent role of FOXP1 and TP63, up to now poorly documented, in the progression of MDS in our patient who is lacking mutations in the TP53 tumor suppressor gene normally associated with poor outcome in myelodysplastic syndrome with 5q-. Finally, our results may suggest a possible broader role of FOXP1 in the pathogenesis and progression of myelodysplasia and acute myeloid leukemia

Luminescence and electron degradation properties of Bi doped CaO phosphor

Energy Technology Data Exchange (ETDEWEB)

Yousif, A. [Department of Physics, University of the Free State, P.O. Box 339, Bloemfontein, ZA 9300 (South Africa); Department of Physics, Faculty of Education, University of Khartoum, P.O. Box 321, 11115 Omdurman (Sudan); Kroon, R.E.; Coetsee, E.; Ntwaeaborwa, O.M. [Department of Physics, University of the Free State, P.O. Box 339, Bloemfontein, ZA 9300 (South Africa); Seed Ahmed, H.A.A. [Department of Physics, University of the Free State, P.O. Box 339, Bloemfontein, ZA 9300 (South Africa); Department of Physics, Faculty of Education, University of Khartoum, P.O. Box 321, 11115 Omdurman (Sudan); Swart, H.C., E-mail: swarthc@ufs.ac.za [Department of Physics, University of the Free State, P.O. Box 339, Bloemfontein, ZA 9300 (South Africa)

2015-11-30

Graphical abstract: - Highlights: • Blue emitting Ca{sub 1−x}O:Bi{sub x=0.5%} phosphor powder was successfully prepared. • Strong blue near-UV emission was obtained. • Electron beam induced cathodoluminescence intensity degradation occurred. • XPS was successfully used to explain the degradation process. - Abstract: Ca{sub 1−x}O:Bi{sub x=0.5%} phosphor powder was successfully synthesized by the sol-gel combustion method. The structure, morphology and luminescent properties of the phosphor were characterized by X-ray diffraction, scanning electron microscopy, photoluminescence and cathodoluminescence (CL) spectroscopy. The results showed that the Ca{sub 1−x}O:Bi{sub x=0.5%} consisted of single face-centred cubic crystals and that the phosphor particles were uniformly distributed. When the phosphor was excited by a xenon lamp at 355 nm, or a 325 nm He–Cd laser, or electron beam, it emitted strongly in the blue near-UV range with a wavelength of 395 nm ({sup 3}P{sub 1} → {sup 1}S{sub 0} transition of Bi{sup 3+}). The CL intensity was monitored as a function of the accelerating voltage and also as a function of the beam current. The powder was also subjected to a prolonged electron beam irradiation to study the electron beam induced CL intensity degradation. X-ray photoelectron spectroscopy was used to analyze the Ca{sub 1−x}O:Bi{sub x=0.5%} phosphor sample surface before and after degradation.

Phosphorous Diffuser Diverged Blue Laser Diode for Indoor Lighting and Communication

KAUST Repository

Chi, Yu-Chieh

2015-12-21

An advanced light-fidelity (Li-Fi) system based on the blue Gallium nitride (GaN) laser diode (LD) with a compact white-light phosphorous diffuser is demonstrated for fusing the indoor white-lighting and visible light communication (VLC). The phosphorous diffuser adhered blue GaN LD broadens luminescent spectrum and diverges beam spot to provide ample functionality including the completeness of Li-Fi feature and the quality of white-lighting. The phosphorous diffuser diverged white-light spot covers a radiant angle up to 120o with CIE coordinates of (0.34, 0.37). On the other hand, the degradation on throughput frequency response of the blue LD is mainly attributed to the self-feedback caused by the reflection from the phosphor-air interface. It represents the current state-of-the-art performance on carrying 5.2-Gbit/s orthogonal frequency-division multiplexed 16-quadrature-amplitude modulation (16-QAM OFDM) data with a bit error rate (BER) of 3.1 × 10−3 over a 60-cm free-space link. This work aims to explore the plausibility of the phosphorous diffuser diverged blue GaN LD for future hybrid white-lighting and VLC systems.

Luminescence properties of dysprosium doped calcium magnesium silicate phosphor by solid state reaction method

Energy Technology Data Exchange (ETDEWEB)

Sahu, Ishwar Prasad, E-mail: ishwarprasad1986@gmail.com [School of Studies in Physics & Astrophysics, Pt. Ravishankar Shukla University, Raipur, C.G. 492010 (India); Chandrakar, Priya; Baghel, R.N.; Bisen, D.P.; Brahme, Nameeta [School of Studies in Physics & Astrophysics, Pt. Ravishankar Shukla University, Raipur, C.G. 492010 (India); Tamrakar, Raunak Kumar [Department of Applied Physics, Bhilai Institute of Technology, Durg, C.G. 491001 (India)

2015-11-15

Dysprosium doped calcium magnesium silicate (CaMgSi{sub 2}O{sub 6}:Dy{sup 3+}) white light emitting phosphor was synthesized by solid state reaction process. The crystal structure of sintered phosphor was monoclinic structure with space group C2/c. Chemical composition of the sintered CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor was confirmed by EDX. The prepared CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor was excited from 352 nm and their corresponding emission spectra were recorded at blue (470 nm), yellow (570 nm) and red (675 nm) line due to the {sup 4}F{sub 9/2} → {sup 6}H{sub 15/2}, {sup 4}F{sub 9/2} → {sup 6}H{sub 13/2}, {sup 4}F{sub 9/2} → {sup 6}H{sub 11/2} transitions of Dy{sup 3+} ions. The combination of these three emissions constituted as white light confirmed by the Commission Internationale de L'Eclairage (CIE) chromatic coordinate diagram. The possible mechanism of the white light emitting long lasting CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor was also investigated. Investigation on afterglow property show that phosphor held fast and slow decay process. The peak of mechanoluminescence (ML) intensity increases linearly with increasing impact velocity of the moving piston. Thus the present investigation indicates that the local piezoelectricity-induced electron bombardment model is responsible to produce ML in prepared CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor. - Highlights: • The crystal structure of CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor is consistent with standard monoclinic structure. • CIE coordinates of CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor is suitable as white light emitting phosphor. • The local piezoelectricity-induced electron bombardment model is responsible to produce ML in CaMgSi{sub 2}O{sub 6}:Dy{sup 3+} phosphor.

Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions

Energy Technology Data Exchange (ETDEWEB)

Jeong, Young-Il [Div. of Malaria and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Osong (Korea, Republic of); Kim, Seung Hyun [Div. of AIDS, National Institute of Health, Korea Centers for Disease Control and Prevention, Osong (Korea, Republic of); Ju, Jung Won; Cho, Shin Hyeong; Lee, Won Ja [Div. of Malaria and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Osong (Korea, Republic of); Park, Jin Wook; Park, Yeong-Min [Dept. of Microbiology and Immunology, College of Medicine, Pusan National University, Yang-San (Korea, Republic of); Lee, Sang Eun, E-mail: ondalgl@cdc.go.kr [Div. of Malaria and Parasitic Diseases, Korea Centers for Disease Control and Prevention, Osong (Korea, Republic of)

2011-04-22

Highlights: {yields} Treatment with Clonorchis sinensis-derived total protein attenuates OVA-induced airway inflammation and AHR to methacholine. {yields} Induction of CD4{sup +}CD25{sup +}Foxp3{sup +} T cells and IL-10 along with suppression of splenocyte proliferation by C. sinensis-derived total protein. {yields} C. sinensis-derived total protein interferes with the expression of co-stimulatory molecules in DCs. -- Abstract: Asthma is characterized by Th2-mediated inflammation, resulting in airway hyperresponsiveness (AHR) through airway remodeling. Recent epidemiological and experimental reports have suggested an inverse relationship between the development of allergy and helminth infections. Infection by Clonorchis sinensis, a liver fluke that resides in the bile duct of humans, is endemic predominantly in Asia including Korea and China. Using a murine model for asthma, we investigated the effects of C. sinensis-derived total protein (Cs-TP) on allergen-induced airway inflammation and the mechanism underlying the protective effects of Cs-TP administration on asthma. Treatment with Cs-TP attenuated OVA-induced airway inflammation and methacholine-induced AHR, as well as eosinophilia development, lymphocyte infiltration into the lung, and goblet cell metaplasia. This protective effect of Cs-TP is associated with markedly reduced OVA-specific IgE and Th1/Th2 cytokine production. Moreover, Cs-TP increased the number of CD4{sup +}CD25{sup +}Foxp3{sup +} regulatory T (Treg) cells as well as their suppressive activity. In fact, proliferation of OVA-restimulated splenocytes was suppressed significantly. Cs-TP also inhibited the expression of such co-stimulatory molecules as CD80, CD86, and CD40 in LPS- or OVA-stimulated dendritic cells (DCs), suggesting that Cs-TP could interfere with the capacity of airway DCs to prime naive T cells. These data demonstrate the capacity of C. sinensis to ameliorate allergic asthma and broaden our understanding of the paradoxical

Flocculation of suspended matter in a crude wet phosphoric acid (Algeria)

International Nuclear Information System (INIS)

Brikci Nigassa, M.; Bensebaa, A.

1994-11-01

Prior to the recovery of uranium, a pre-treatment of the phosphoric acid is necessary to remove soluble impurities of different origins. In this work, synthetic flocculants have been used. the influence of operating conditions on flocculation and filtration, such as, type of flocculants, polymer concentration, temperature, mixing and time of agitation, has been studied for both aged and fresh phosphoric acid. It has been shown that synthetic flocculants can be used for flocculation ins a phosphoric acid medium and that flocculation and filtration processes are strongly linked

Scaling Up: Kilolumen Solid-State Lighting Exceeding 100 LPW via Remote Phosphor

Energy Technology Data Exchange (ETDEWEB)

Waqidi Falicoff

2008-09-15

This thirty-month project was successful in attaining its ambitious objectives of demonstrating a radically novel 'remote-phosphor' LED light source that can out-perform conventional conformal coated phosphor LED sources. Numerous technical challenges were met with innovative techniques and optical configurations. This product development program for a new generation of solid-state light sources has attained unprecedented luminosity (over 1 kilo-lumen) and efficacy (based on the criterion lumens per 100mw radiant blue). LPI has successfully demonstrated its proprietary technology for optical synthesis of large uniform sources out of the light output of an array of separated LEDs. Numerous multiple blue LEDs illuminate single a phosphor patch. By separating the LEDs from the phosphor, the phosphor and LEDs operate cooler and with higher efficiency over a wide range of operating conditions (from startup to steady state). Other benefits of the system include: better source uniformity, more types of phosphor can be used (chemical interaction and high temperatures are no longer an issue), and the phosphor can be made up from a pre-manufactured sheet (thereby lowering cost and complexity of phosphor deposition). Several laboratory prototypes were built and operated at the expected high performance level. The project fully explored two types of remote phosphor system: transmissive and reflective. The first was found to be well suited for a replacement for A19 type incandescent bulbs, as it was able to replicate the beam pattern of a traditional filament bulb. The second type has the advantages that it is pre-collimate source that has an adjustable color temperature. The project was divided in two phases: Phase I explored a transmissive design and Phase II of the project developed reflective architectures. Additionally, in Phase II the design of a spherical emitting transmissive remote phosphor bulb was developed that is suitable for replacement of A19 and

Zero- and two-dimensional hybrid carbon phosphors for high colorimetric purity white light-emission.

Science.gov (United States)

Ding, Yamei; Chang, Qing; Xiu, Fei; Chen, Yingying; Liu, Zhengdong; Ban, Chaoyi; Cheng, Shuai; Liu, Juqing; Huang, Wei

2018-03-01

Carbon nanomaterials are promising phosphors for white light emission. A facile single-step synthesis method has been developed to prepare zero- and two-dimensional hybrid carbon phosphors for the first time. Zero-dimensional carbon dots (C-dots) emit bright blue luminescence under 365 nm UV light and two-dimensional nanoplates improve the dispersity and film forming ability of C-dots. As a proof-of-concept application, the as-prepared hybrid carbon phosphors emit bright white luminescence in the solid state, and the phosphor-coated blue LEDs exhibit high colorimetric purity white light-emission with a color coordinate of (0.3308, 0.3312), potentially enabling the successful application of white emitting phosphors in the LED field.

TL-OSL study of Li{sub 3}PO{sub 4}: Mg, Cu phosphor

Energy Technology Data Exchange (ETDEWEB)

Rahangdale, S. R., E-mail: sachin.rahangdale1@gmail.com; Wankhede, S. P. [Department of Physics, K.D.K.College of Engineering, Nagpur (India); Dhabekar, B. S. [RPAD, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India); Palikundwar, U. A.; Moharil, S. V. [Department of Physics, RTM Nagpur University, Nagpur, 440010 (India)

2015-08-28

In the present work, we report the thermoluminescence and optically stimulated luminescence properties of Mg and Cu doped Li{sub 3}PO{sub 4} phosphor. The phosphor was synthesized by precipitation method. The thermoluminescence dosimetric peak temperature for the phosphor varies with concentrations of Mg and Cu. Li{sub 3}PO{sub 4} shows good response to 470nm optical stimulation. The OSL sensitivity of the phosphor is approximately 12 times than that of standard Lithium magnesium phosphate. This study may help to develop this material for the application in real time dosimetry using optically stimulated luminescence.

Technique of proton and phosphorous MR spectroscopy; Technik der Protonen- und Phosphor-MR-Spektroskopie

Energy Technology Data Exchange (ETDEWEB)

Backens, M. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany)

2017-06-15

Magnetic resonance spectroscopy (MRS) is an important non-invasive method that can reveal the concentration and spatial distribution of particular biochemically relevant tissue metabolites. Proton MRS is routinely applicable in the clinical setting providing good quality results even with a moderate magnetic field strength of 1.5 T. Relative values of metabolite concentrations are mostly used for the assessment of metabolic disorders. Absolute quantification of metabolites can be achieved by means of internal or external reference scans. Phosphorous MRS extends the range of detectable molecules to energy and cell membrane metabolism. The lower detection limit of metabolite concentrations is in the range of some mmol/kg. Depending on the magnetic field strength, MRS enables a spatial resolution of a few milliliters. The use of phosphorous MRS is considerably limited because higher field strengths of at least 3.0 T and additional expensive hardware for signal processing are required. (orig.) [German] Die MR-Spektroskopie (MRS) ist eine wichtige nichtinvasive Untersuchungsmethode, die Konzentration und raeumliche Verteilung einiger biochemisch relevanter Metaboliten im Gewebe ermitteln kann. Die Protonenspektroskopie ist klinisch etabliert, in der Routine einfach durchfuehrbar und liefert bereits bei einer Magnetfeldstaerke von 1,5 T qualitativ gute Ergebnisse. Fuer die Beurteilung von Stoffwechselveraenderungen werden Metabolitenkonzentrationen meist als Relativwerte angegeben. Mithilfe interner oder externer Referenzmessungen sind auch absolute Metabolitenkonzentrationen berechenbar. Die Phosphorspektroskopie erweitert den Bereich der detektierbaren Molekuele auf den Energie- und Zellmembranstoffwechsel. Die minimale nachweisbare Metabolitenkonzentration liegt bei einigen mmol/kg. Abhaengig von der Magnetfeldstaerke ist eine raeumliche Aufloesung der MRS von wenigen Millilitern erreichbar. Der Einsatz der Phosphor-MRS wird dadurch erheblich eingeschraenkt, dass sie

Rational Degenerations of M-Curves, Totally Positive Grassmannians and KP2-Solitons

Science.gov (United States)

Abenda, Simonetta; Grinevich, Petr G.

2018-03-01

We establish a new connection between the theory of totally positive Grassmannians and the theory of M-curves using the finite-gap theory for solitons of the KP equation. Here and in the following KP equation denotes the Kadomtsev-Petviashvili 2 equation [see (1)], which is the first flow from the KP hierarchy. We also assume that all KP times are real. We associate to any point of the real totally positive Grassmannian Gr^{tp} (N,M) a reducible curve which is a rational degeneration of an M-curve of minimal genus {g=N(M-N)} , and we reconstruct the real algebraic-geometric data á la Krichever for the underlying real bounded multiline KP soliton solutions. From this construction, it follows that these multiline solitons can be explicitly obtained by degenerating regular real finite-gap solutions corresponding to smooth M-curves. In our approach, we rule the addition of each new rational component to the spectral curve via an elementary Darboux transformation which corresponds to a section of a specific projection Gr^{tp} (r+1,M-N+r+1)\\mapsto Gr^{tp} (r,M-N+r).

Contrast and decay of cathodoluminescence from phosphor particles in a scanning electron microscope

Energy Technology Data Exchange (ETDEWEB)

Engelsen, Daniel den; Harris, Paul G.; Ireland, Terry G., E-mail: terry.ireland@brunel.ac.uk; Fern, George R.; Silver, Jack

2015-10-15

Cathodoluminescence (CL) studies are reported on phosphors in a field emission scanning electron microscope (FESEM). ZnO: Zn and other luminescent powders manifest a bright ring around the periphery of the particles: this ring enhances the contrast. Additionally, particles resting on top of others are substantially brighter than underlying ones. These phenomena are explained in terms of the combined effects of electrons backscattered out of the particles, together with light absorption by the substrate. The contrast is found to be a function of the particle size and the energy of the primary electrons. Some phosphor materials exhibit a pronounced comet-like structure at high scan rates in a CL-image, because the particle continues to emit light after the electron beam has moved to a position without phosphor material. Image analysis has been used to study the loss of brightness along the tail and hence to determine the decay time of the materials. The effect of phosphor saturation on the determination of decay times by CL-microscopy was also investigated. - Highlights: • Contrast enhancement are observed in secondary electron and cathodoluminescent images of phosphor particles sitting on top of others. • Backscattered electrons largely explain the observed contrast enhancement. • After glow effects in CL-micrographs of phosphors enable the determination of decay times. • Phosphor saturation can be used to determine the decay time of individual spectral transitions.

ESTADO DEL ARTE MPLS-TP CONMUTACIÓN MULTIPROTOCOLO MEDIANTE ETIQUETAS - PERFIL DE TRANSPORTE

Directory of Open Access Journals (Sweden)

Lois Albert Espinel García

2013-09-01

Full Text Available La creciente demanda en servicios de telecomunicaciones genera la necesidad de desarrollar diferentes modelos de red. En el año 2008, la UIT-T une sinergias con la IETF para desarrollar un protocolo llamado MPLS-TP cuya arquitectura representa el resultado la agregación de la eficiencia en el transporte de paquetes de IP/MPLS con la fiabilidad en el transporte de SONET/SDH. Este trabajo presenta un estado del arte de MPLS-TP donde se plasman los estudios actuales y avances relacionados con ésta tecnología: modelos de arquitectura óptica, modelos de protección en OAM. Además se presenta la estructura, funcionamiento y características que hacen de MPLS-TP una opción para las redes de transporte de siguiente generación. El material de apoyo para el desarrollo de este artículo ha sido obtenido de la base documental de recursos electrónicos con contenido científico de apoyo a la investigación de la Universidad Distrital Francisco José de Caldas.

Stress Rupture and Precipitation Behavior of TP310HCbN(HR3C for Supercritical Boilers

Directory of Open Access Journals (Sweden)

FANG Xu-dong

2017-06-01

Full Text Available Using persistent experiment method, combined with Gleeble,hardness analysis, SEM, EDS, TEM and other analytical methods, the hot deformation, stress rupture and precipitation behavior of TP310HCbN heat resistance steel was analysed at 650℃ and 700℃, the results show that:the change of the hardness is not obviously under two different stress rupture temperature; with stress rupture time prolongs, TP310HCbN heat-resistant steel intragranular precipitates from granular into rod-shaped, and presence of wormlike NbCrN rich precipitates and dislocation interactions; Taiyuan Iron and Steel production of TP310HCbN heat-resistant steel at 650/700℃-100000h extrapolation lasting strength meet the standard requirements.

TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan.

Science.gov (United States)

Iwayanagi, Takao; Miyamoto, Sei; Konno, Takeshi; Mizutani, Hisashi; Hirai, Tomohiro; Shigemoto, Yasumasa; Gojobori, Takashi; Sugawara, Hideaki

2012-09-01

The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index_e.html .

Structural and spectral properties of MgZnO2:Sm3+ phosphor

Science.gov (United States)

Rajput, Preasha; Sharma, Pallavi; Biswas, Pankaj; Kamni

2018-05-01

The samarium doped MgZnO2 phosphor was synthesized by the low-cost combustion method. The powder X-ray diffraction (XRD) analysis confirmed the crystallinity and phase purity of the phosphor. The lattice parameters were determined by indexing the diffraction peaks. The photoluminescence (PL) study revealed that the phosphor exhibited a broad excitation band in the UV region ranging between 200 to 350 nm. The 601 nm emission was ascribed to 4G5/2 to 6H7/2 transitions of the Sm3+ ion. The optical bandgap of MgZnO2:Sm3+ was obtained to be 3.56 eV. The phosphor can be projected as a useful material in X- and gamma-ray scintillators.

Critical issues in enhancing brightness in thin film phosphors for flat-panel display applications

International Nuclear Information System (INIS)

Singh, R.K.; Chen, Z.; Kumar, D.; Cho, K.; Ollinger, M.

2002-01-01

Thin film phosphors have potential applications in field emission flat-panel displays. However, they are limited by the lower cathodoluminescent brightness in comparison to phosphor powders. In this paper, we have investigated the critical parameters that need to be optimized to increase the brightness of phosphor thin films. Specifically, we studied the role of surface roughness and optical properties of the substrate on the brightness of the phosphor films. Thin Y 2 O 3 :Eu phosphor films were deposited on various substrates (lanthanum aluminate, quartz, sapphire, and silicon) with thicknesses varying from 50 to 500 nm. A model that accounts for diffuse and specular or scattering effects has been developed to understand the effects of the microstructure on the emission characteristics of the cathodoluminescent films. The results from the model show that both the optical properties of the substrate and the surface roughness of the films play a critical role in controlling the brightness of laser deposited phosphor films

Contribution of germline TP53 variants and assessment of HER-2 status among young breast cancer patients in Malaysia

Directory of Open Access Journals (Sweden)

Shao Yan Lau

2017-12-01

Full Text Available Background: Li-Fraumeni Syndrome (LFS is caused by a mutation in the TP53 tumour suppressor gene. This rare hereditary condition predisposes individuals to an increased risk of cancers including breast cancer in women at a relatively young age, which accounts for nearly 25%–30% of all LFS‑associated cancers. Studies have shown that breast tumours in women with a germline TP53 deleterious variants are associated with a human epidermal growth factor receptor 2 (HER2-positive phenotype. Taken together, this study aimed to investigate the contribution of germline TP53 variants and its association with tumour HER-2 status in a cohort of young women with breast cancer. Methods: From 2002 to 2017, 4048 women with breast cancer treated at University Malaya Medical Centre or Sime Darby Medical Centre participated in the Malaysian Breast Cancer Genetics Study. Of which, 87 patients were diagnosed before 30 years of age. All patients were analysed for germline TP53 single nucleotide variants, small insertions or deletions by amplicon‑based targeted sequencing and validated by Sanger sequencing. DNA from patients who tested negative for sequencing were subsequently evaluated for the presence of TP53 exon deletions or duplications by multiplex ligation‑dependent probe amplification. HER-2 status of breast tumours was defined by immunohistochemistry, fluorescence in situ hybridisation and/or silver in situ hybridisation. Results: 5 distinct TP53 variants were detected in 5 individuals. 3 out of 5 TP53 variants were classified as frameshift mutations, one nonsense mutation and one in-frame duplication. Variants in other genes were detected in 17 individuals. No large genomic rearrangements were detected in the remaining 65 sequencing-negative patients. The assessment of HER-2 status will be presented. Conclusions: Our results suggest that alterations in TP53 gene were identified in approximately 5.7% (5/87 of this cohort of young women with breast

Mechanoluminescence and photoluminescence of Pr3+ activated KMgF3 phosphor

International Nuclear Information System (INIS)

Dhoble, S.J.; Kher, R.S.; Furetta, C.

2003-01-01

A Czochralski method for the preparation of crystalline KMgF 3 : Pr phosphors are reported. Photoluminescence (PL) and mechanoluminescence (ML) characteristics are studied. Photoluminescence of Pr 3+ activated KMgF 3 shows the strong emission of Pr 3+ ions were observed at 498 and 650 nm by excitation of 213 mn. ML of KMgF 3 : Pr 3+ shows two peaks, which have been observed in ML intensity versus time curve. The ML peak shows the recombination of electrons with free radical (anion radical produced by γ-irradiation) released from two type traps during the mechanical pressure applied on KMgF 3 : Pr 3+ phosphor. It has a supra linear ML response with γ-ray exposure and a negligible fading. These properties of phosphor should be suitable in dosimetry of ionization relation using ML technique. Therefore the KMgF 3 : Pr 3+ phosphor proposed for ML dosimetry of ionization radiations. (Author)

Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer

Czech Academy of Sciences Publication Activity Database

Naccarati, Alessio; Poláková, Veronika; Pardini, Barbara; Vodičková, Ludmila; Hemminki, K.; Kumar, R.; Vodička, Pavel (ed.)

2012-01-01

Roč. 27, č. 2 (2012), s. 211-218 ISSN 0267-8357 R&D Projects: GA ČR GP305/09/P194; GA ČR GAP304/10/1286 Grant - others:GA UK(CZ) GA96908/B/2008 Institutional research plan: CEZ:AV0Z50390512 Keywords : TP53 mutations * TP53 polymorphisms * cancer risk Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.500, year: 2012

Winter Performance of Inter-Locking Pavers—Stormwater Quantity and Quality

Directory of Open Access Journals (Sweden)

Angus Chu

2012-12-01

Full Text Available This study examined the effectiveness of open-joint inter-locking pavers in a permeable pavement in cold (winter conditions. A field-scale inter-locking paver cell (UNI Eco-Optiloc® was built to evaluate the hydraulic performance and water quality improvements experienced during freeze-thaw and frozen conditions in Calgary, Alberta, Canada. Hydraulic performance was assessed using stormwater runoff reduction (peaks and volumes and surface infiltration capacity. Water quality performance for removal of total suspended solids (TSS, total nitrogen (TN, total phosphorous (TP and three heavy metals: copper, lead and zinc, was assessed. Results from the study demonstrated that the inter-locking pavers were effective in attenuating stormwater runoff peak volumes. The surface infiltration capacity decreased significantly due to the deposition of sanding and de-icing materials on the pavement surface during winter operation. Infiltrated stormwater was stored and treated within the pavement structure, which showed removal rates of 91% for TSS, 78% for TP, 6% for TN, 68% for zinc, 69% for copper and 55% for lead.

Phylogenetic analysis of human Tp53 gene using computational ...

African Journals Online (AJOL)

The TP53 gene encoding p53 protein is involved in regulating a series of pathways. New discoveries about the function and control of p53 are still in progress and it is hoped to develop better therapeutics and diagnostics by exploiting this system. Evolutionary studies are of prime importance in the field of biological ...

Rare earth activated yttrium aluminate phosphors with modulated luminescence.

Science.gov (United States)

Muresan, L E; Popovici, E J; Perhaita, I; Indrea, E; Oro, J; Casan Pastor, N

2016-06-01

Yttrium aluminate (Y3 A5 O12 ) was doped with different rare earth ions (i.e. Gd(3+) , Ce(3+) , Eu(3+) and/or Tb(3+) ) in order to obtain phosphors (YAG:RE) with general formula,Y3-x-a Gdx REa Al5 O12 (x = 0; 1.485; 2.97 and a = 0.03). The synthesis of the phosphor samples was done using the simultaneous addition of reagents technique. This study reveals new aspects regarding the influence of different activator ions on the morpho-structural and luminescent characteristics of garnet type phosphor. All YAG:RE phosphors are well crystallized powders containing a cubic-Y3 Al5 O12 phase as major component along with monoclinic-Y4 Al2 O9 and orthorhombic-YAlO3 phases as the impurity. The crystallites dimensions of YAG:RE phosphors vary between 38 nm and 88 nm, while the unit cell slowly increase as the ionic radius of the activator increases. Under UV excitation, YAG:Ce exhibits yellow emission due to electron transition in Ce(3+) from the 5d level to the ground state levels ((2) F5/2 , (2) F7/2 ). The emission intensity of Ce(3+) is enhanced in the presence of the Tb(3+) ions and is decreased in the presence of Eu(3+) ions due to some radiative or non-radiative processes that take place between activator ions. By varying the rare earth ions, the emission colour can be modulated from green to white and red. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Decrease of total antioxidant capacity during coronary artery bypass surgery.

Science.gov (United States)

Kunt, Alper Sami; Selek, Sahbettin; Celik, Hakim; Demir, Deniz; Erel, Ozcan; Andac, Mehmet Halit

2006-09-01

Cardiac surgery induces an oxidative stress, which may lead to impairment of cardiac function. In this study, we aimed to measure the changes of oxidative and antioxidative status of patients undergoing coronary artery bypass surgery (CABG). We studied 79 patients who underwent CABG with and without cardiopulmonary bypass (CPB). Of the 79 patients, 39 had CPB and 40 did not. Blood samples were drawn before, during, and after the surgery. Antioxidant status was evaluated by measuring total antioxidant capacity (TAC), and oxidative status was evaluated by measuring total peroxide (TP) levels and oxidative stress index (OSI). TP and OSI levels increased, while TAC decreased progressively after the beginning of surgery, for all patients. There were negative correlations between TAC levels and aortic cross-clamping period and anastomosis time ( r = -0.553, p antioxidant vitamins such as vitamins C and E may be beneficial for patients undergoing CABG.

Characterization of metallic surfaces in phosphorous-bronze ordered packings

International Nuclear Information System (INIS)

Sandru, Claudia; Titescu, Gh.

1997-01-01

Copper and its alloys, particularly the phosphorous bronze, are characterized by a high water wettability as compared with other materials. This feature led to utilization of phosphorous bronze in fabrication of contact elements, a packing type equipping the distillation columns. For heavy water separation by isotopic distillation under vacuum, ordered packings of phosphorous bronze networks were fabricated. The superior performances of these packings are determined by the material and also by the geometrical form and the state of the metallic surface. Thus, a procedure of evaluating the wettability has been developed, based on tests of the network material. The results of the tests constitute a criterion of rating the functional performances of packings, particularly of their efficiencies. Also, investigation techniques of the chemical composition and of the thickness of superficial layer on the packing were developed. It was found that the packing surface presents a layer of about 5-20 μm formed mainly by oxides of copper, tin, and, depending on the packing treatment, of oxides of other elements coming from the treatment agent. The paper presents characterization of phosphorous bronze treated with potassium permanganate, a specific treatment for improving the functional performances of the packings used in the heavy water concentration and re-concentration installations

Rhabdomyosarcoma-associated renal cell carcinoma: a link with constitutional Tp53 mutation.

LENUS (Irish Health Repository)

Curry, Sarah

2012-02-01

The 2004 World Health Organization classification includes the new entity "neuroblastoma-associated renal cell carcinoma." The pathogenetic link between these entities is unknown as yet. The patient reported herein developed renal cell carcinoma after anaplastic embryonal rhabdomyosarcoma, a previously unknown association. The 2nd malignancy developed very soon after the 1st one, prompting concern for inherent cancer predisposition rather than a therapy-induced 2nd malignancy. A variety of features raised suspicion for Tp53 mutation, and indeed a pathogenic germline Tp53 mutation was identified in this child, despite a negative family history for Li-Fraumeni syndrome. Consideration of underlying predisposition is advocated in the context of rapid evolution of 2nd childhood malignancy.

TP53 mutation and human papilloma virus status of oral squamous cell carcinomas in young adult patients

NARCIS (Netherlands)

Braakhuis, B.J.M.; Rietbergen, M.M.; Buijze, M.; Snijders, P.J.F.; Bloemena, E.; Brakenhoff, R.H.; Leemans, C.R.

2014-01-01

Objective Little is known about the molecular carcinogenesis of oral squamous cell carcinoma (OSCC) in young adult patients. The aim of this study was to investigate the detailed TP53 mutation and human papilloma virus (HPV) status of OSCC in patients, younger than 45 years. Methods TP53 mutations

Prognostic value of TP53 transcriptional activity on p21 and bax in patients with esophageal squamous cell carcinomas treated by definitive chemoradiotherapy

International Nuclear Information System (INIS)

Michel, Pierre; Magois, Karine; Robert, Valerie; Chiron, Anne; Lepessot, Florence; Bodenant, Corinne; Roque, Isabelle; Seng, Sok H.; Frebourg, Thierry; Paillot, Bernard

2002-01-01

Purpose: The aim of this study was to evaluate biologic factors on survival and clinical response after definitive concomitant chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC). Methods and Materials: TP53 protein hyperexpression (immunochemistry [IHC]) and functional assay (FA) of TP53, measuring the ability of TP53 to transactivate p21 and bax reporter systems, were performed in patients with ESCC treated by CRT. The impact of parameters studied on survival and clinical response to CRT was assessed. Results: Thirty-eight patients with ESCC were included. TP53 alterations were detected in 84.2% of cases with FA. All TP53 mutations abolished the transactivation of p21 and bax reporter systems. After CRT, complete response rate was 55.3%. The median survival of the population was 17.5 months. Serum albumin (p=0.002), weight loss <10% (p=0.005), and response to treatment (p<0.001) were significantly linked with survival. TP53 alteration in FA was not significantly predictive of response to CRT (p=0.132) nor survival (p=0.154). Conclusions: Our results suggest that wild-type TP53 in ESCC could be associated with good response to definitive CRT. However, the small rate of ESCC with wild-type TP53 suggests that systematic determination of TP53 status is not appropriate for the management of the ESCC population

The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

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Momoko Ishimine

2018-01-01

Full Text Available Irinotecan (CPT-11 is an anticancer prodrug that is activated by the carboxylesterase CES2 and has been approved for the treatment of many types of solid tumors, including colorectal cancer. Recent studies with cell lines show that CES2 expression is regulated by the tumor suppressor protein p53. However, clinical evidence for this regulatory mechanism in cancer is lacking. In this study, we examined the relationship between TP53 gene status and CES2 expression in human colorectal cancer. Most colorectal cancer specimens (70%; 26 of 37 showed lower CES2 mRNA levels (≥1.5-fold lower than the adjacent normal tissue, and only 30% (12 of 37 showed similar (<1.5-fold lower or higher CES2 mRNA levels. However, TP53 gene sequencing revealed no relationship between CES2 downregulation and TP53 mutational status. Moreover, while colorectal cancer cells expressing wild-type p53 exhibited p53-dependent upregulation of CES2, PRIMA-1MET, a drug that restores the transcriptional activity of mutant p53, failed to upregulate CES2 expression in cells with TP53 missense mutations. These results, taken together, suggest that CES2 mRNA expression is decreased in human colorectal cancer independently of p53.

Study of some thermoluminescent phosphors for the dosimetry of ionizing radiations

International Nuclear Information System (INIS)

Jaafari, M.

1983-01-01

Thermoluminescence dosimetry techniques are reviewed and interactions radiation matter are recalled. The need for new phosphors is evidenced. Numerous phosphors are examined and calcium, strontium and barium sulfides are synthetized and deposited on glass supports. The thermoluminescence of the dosimeters obtained with these materials is analyzed [fr

TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia

OpenAIRE

Wegert, Jenny; Vokuh, Christian; Ziegler, Barbara; Ernestus, Karen; Leuschner, Ivo; Furtwängler, Rhoikos; Graf, Norbert; Gessler, Manfred

2018-01-01

TP53 mutations have been associated with anaplasia in Wilms tumour, which conveys a high risk for relapse and fatal outcome. Nevertheless, TP53 alterations have been reported in no more than 60% of anaplastic tumours, and recent data have suggested their presence in tumours that do not fulfil the criteria for anaplasia, questioning the clinical utility of TP53 analysis. Therefore, we characterized the TP53 status in 84 fatal cases of Wilms tumour, irrespective of histological subtype. We iden...

TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia

OpenAIRE

Wegert, Jenny; Vokuhl, Christian; Ziegler, Barbara; Ernestus, Karen; Leuschner, Ivo; Furtwängler, Rhoikos; Graf, Norbert; Gessler, Manfred

2017-01-01

Abstract TP53 mutations have been associated with anaplasia in Wilms tumour, which conveys a high risk for relapse and fatal outcome. Nevertheless, TP53 alterations have been reported in no more than 60% of anaplastic tumours, and recent data have suggested their presence in tumours that do not fulfil the criteria for anaplasia, questioning the clinical utility of TP53 analysis. Therefore, we characterized the TP53 status in 84 fatal cases of Wilms tumour, irrespective of histological subtype...

Carvacrol attenuates serum levels of total protein, phospholipase A2 and histamine in asthmatic guinea pig

Directory of Open Access Journals (Sweden)

Mohammad Hossein Boskabady

2016-11-01

Full Text Available Objective: Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP, phospholipase A2 (PLA2 and histamine in sensitized guinea pigs was evaluated. Materials and Methods: Sensitized guinea pigs were given drinking water alone (group S, drinking water containing three concentrations of carvacrol (40, 80 and 160 µg/ml or dexamethasone. Serum levels of TP, PLA2 and histamine were examined I all sensitized groups as well as a non-sensitized control group (n=6 for each group. Results: In sensitized animals, serum levels of TP, PLA2 and histamine were significantly increased compared to control animals (p

Comparative changes in monthly blood urea nitrogen, total protein ...

African Journals Online (AJOL)

The objective of this study was to determine the comparative changes in the monthly blood urea nitrogen (BUN) concentration, total protein (TP) concentration in blood serum and the body condition score of Nguni cows and heifers raised on sweetveld. Twenty-four clinically healthy animals in different parities, namely Parity ...

TP53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk: a case control study in a Chinese population

OpenAIRE

Li, Yanli; Chang, Shen-Chih; Niu, Rungui; Liu, Li; Crabtree-Ide, Christina R; Zhao, Baoxing; Shi, Jianping; Han, Xiaoyou; Li, Jiawei; Su, Jia; Cai, Lin; Yu, Shunzhang; Zhang, Zuo-Feng; Mu, Lina

2013-01-01

Abstract Background A pathway-based genotyping analysis suggested rs2078486 was a novel TP53 SNP, but very few studies replicate this association. TP53 rs1042522 is the most commonly studied SNP, but very few studies examined its potential interaction with environmental factors in relation to lung cancer risk. This study aims to examine associations between two TP53 single-nucleotide polymorphisms (SNPs) (rs2078486, rs1042522), their potential interac...

Use of the Vettest 8008 and refractometry for determination of total protein, albumin, and globulin concentrations in feline effusions.

Science.gov (United States)

Papasouliotis, Kostas; Murphy, Kate; Dodkin, Steve; Torrance, Andy G

2002-01-01

Pleural and peritoneal effusion is a common clinical finding in feline practice. Determination of fluid albumin (ALB) and globulin (GLOB) concentrations in addition to total protein (TP) concentration can be helpful in diagnosing or ruling out certain diseases in cats, especially feline infectious peritonitis (FIP). The objective of this study was to compare effusion TP, ALB, and GLOB results obtained by a refractometer and a bench-top dry chemistry analyzer with those results obtained by a reference method. Twenty-six pleural and 14 peritoneal effusion samples were analyzed from 40 cats with various diseases. TP and ALB concentrations were determined by a reference automated wet chemistry analyzer (Kone Specific, Kone Instruments, Espoo, Finland), a bench-top dry chemistry analyzer (Vettest 8008, IDEXX Laboratories Ltd, Chalfont St Peter, UK), and a refractometer (Atago SPR-T2, Atago Co, Tokyo, Japan). GLOB, albumin to globulin (A/G) ratio, and globulins as a percentage of total proteins (GLOB%) were calculated. Results were analyzed by paired t tests, difference plots, and Deming s regression analysis. Correlation coefficients (r) for TP with Vettest versus Kone and refractometer versus Kone methods were.97 and.94, respectively. GLOB and GLOB% values were significantly higher and A/G ratios were significantly lower with Vettest versus Kone methods. Correlation coefficients for ALB, GLOB, GLOB% and A/G ratio with Vettest versus Kone methods were.86,.93,.82, and.73, respectively. Although correlation with other methods was good, the refractometer underestimated TP concentrations in 3 samples. The refractometer is an acceptable method for determination of TP concentration in feline effusions. The Vettest 8008 also is an acceptable method for the determination of TP and ALB concentrations, however, calculated A/G ratios obtained with the Vettest are unacceptable.

Gene-gene interaction between MSX1 and TP63 in Asian case-parent trios with nonsyndromic cleft lip with or without cleft palate.

Science.gov (United States)

Liu, Dongjing; Schwender, Holger; Wang, Mengying; Wang, Hong; Wang, Ping; Zhu, Hongping; Zhou, Zhibo; Li, Jing; Wu, Tao; Beaty, Terri H

2018-03-01

Small ubiquitin-like modification, also known as sumoylation, is a crucial post-translational regulatory mechanisms involved in development of the lip and palate. Recent studies reported two sumoylation target genes, MSX1 and TP63, to have achieved genome-wide level significance in tests of association with nonsyndromic clefts. Here, we performed a candidate gene analysis considering gene-gene and gene-environment interaction for SUMO1, MSX1, and TP63 to further explore the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P). A total of 130 single-nucleotide polymorphisms (SNPs) in or near SUMO1, MSX1, and TP63 was analyzed among 1,038 Asian NSCL/P trios ascertained through an international consortium. Conditional logistic regression models were used to explore gene-gene (G × G) and gene-environment (G × E) interaction involving maternal environmental tobacco smoke and multivitamin supplementation. Bonferroni correction was used for G × E analysis and permutation tests were used for G × G analysis. While transmission disequilibrium tests and gene-environment interaction analysis showed no significant results, we did find signals of gene-gene interaction between SNPs near MSX1 and TP63. Three pairwise interactions yielded significant p values in permutation tests (rs884690 and rs9290890 with p = 9.34 × 10 -5 and empirical p = 1.00 × 10 -4 , rs1022136 and rs4687098 with p = 2.41 × 10 -4 and empirical p = 2.95 × 10 -4 , rs6819546 and rs9681004 with p = 5.15 × 10 -4 and empirical p = 3.02 × 10 -4 ). Gene-gene interaction between MSX1 and TP63 may influence the risk of NSCL/P in Asian populations. Our study provided additional understanding of the genetic etiology of NSCL/P and underlined the importance of considering gene-gene interaction in the etiology of this common craniofacial malformation. © 2018 Wiley Periodicals, Inc.

[Total pollution features of urban runoff outlet for urban river].

Science.gov (United States)

Luo, Hong-Bing; Luo, Lin; Huang, Gu; He, Qiang; Liu, Ping

2009-11-01

The urban stormwater runoff discharged to urban river, especially to rainfall source river, cannot be ignored. In this study, the Futian River watershed in Shenzhen city in a typical southern city of China is taken as the research object. In order to guide the pollution control for urban river, the eighteen rainfall events were monitored, and the total pollution features of the urban runoff outlet for this urban river were analyzed and discussed by using the process of pollutographs, the identifying to first flush, event mean concentration (EMC), etc. Results show that the concentrations of COD, SS, TN, TP and BOD5 are ten times more than the grade V of the environmental quality standards for surface water during the runoff time; the pollution caused by heavy metals (Cr, Ge, Cu, Hg and As) in runoff at a typical rainfall event is serious; the average and range of pollutant concentration at this runoff outlet in study area are evidently higher than at Shapingba in Chongqing city of China and at Silerwood in Canada, but are lower than at Shilipu in Wuhan city of China. The first flushes of COD, SS, BOD5, especially COD and SS, are evident, but the TN and TP are not. The average EMC of COD, TN, TP and BOD5 are 224.14, 571.15, 5.223, 2.04, 143.5 mg/L, respectively. To some extent, the EMC of COD is about two times of the value of the near cities, Macao and Zhuhai. The EMC of TN and TP are obviously higher than Beijing, Guangzhou and Shanghai. To compared with foreign counties, the EMC of the study area in Shenzhen is obviously much higher than the cities of Korean, USA and Canada. So the total pollution caused by the urban surface runoff in study area is serious and necessary to be treated.

Systematically controlled pore system of ordered mesoporous carbons using phosphoric acid as the in situ generated catalysts for carbonization and activation

Energy Technology Data Exchange (ETDEWEB)

Jin, Xing; Lee, Chang Hyun; Kim, Jin Hoe; You, Dae Jong; Shon, Jeong Kuk; Kim, Ji Man [Dept. of Chemistry, Sungkyunkwan University, Suwon (Korea, Republic of); Pak, Chan Ho [Fuel Cell Group, Corporate R and D Center, Samsung SDI Co. Ltd., Yongin (Korea, Republic of)

2015-08-15

We report on a facile synthesis of the ordered mesoporous carbon (OMC) materials with systematically controlled microporosity and mesoporosity simultaneously through the nano-replication route using phosphoric acid as the acid catalyst and activation agent. The use of phosphoric acid affects the pore structures of OMC materials, such as the formation of numerous micropores by activation of the carbon framework and the enlargement of mesopores by spontaneous phase separation during the carbonization. The mesopore sizes, surface areas, total pore volumes, and micropore volumes of the OMC materials are highly dependent on the phosphoric acid content and can be systematically controlled in the range 3.7–7.5 nm, 1027–2782 m{sup 2} g{sup -1}, 1.12–3.53 cm{sup 3} g{sup -1} and 0.34–0.95 cm{sup 3} g{sup -1}, respectively. OMC materials with systematically controlled pore structures were successfully synthesized using phosphoric acid as the carbonization catalyst and mesoporous silica materials with cubic Ia3d and 2-D hexagonal mesostructures as the templates. The phosphoric acid in the synthesis of ordered mesoporous carbon materials acts as the chemical activating agent for micropore generation of the carbon framework and pore-expanding agent for controlling of mesopore size, in addition to functioning as the acid catalyst. The present synthesis pathway is very useful for preparing OMC materials with tunable mesopore sizes and well-developed microporosities at the same time.

Oxidation-extraction of uranium from wet-process phosphoric acid

International Nuclear Information System (INIS)

Lawes, B.C.

1985-01-01

The invention involves an improvement to the reductive stripping process for recovering uranium values from wet-process phosphoric acid solution, where uranium in the solution is oxidized to uranium (VI) oxidation state and then extracted from the solution by contact with a water immiscible organic solvent, by adding sufficient oxidant, hydrogen peroxide, to obtain greater than 90 percent conversion of the uranium to the uranium (VI) oxidation state to the phosphoric acid solution and simultaneously extracting the uranium (VI)

Radionuclide concentrations in raw and purified phosphoric acids from Brazil and their processing wastes: implications for radiation exposures.

Science.gov (United States)

da Conceição, Fabiano Tomazini; Antunes, Maria Lúcia Pereira; Durrant, Steven F

2012-02-01

Radionuclides from the U and Th natural series are present in alkaline rocks, which are used as feedstock in Brazil for the production of raw phosphoric acid, which can be considered as a NORM (naturally occurring radioactive material). As a result of the purification of raw phosphoric acid to food-grade phosphoric acid, two by-products are generated, i.e., solid and liquid wastes. Taking this into account, the main aim of this study was to evaluate the fluxes of natural radionuclide in the production of food-grade phosphoric acids in Brazil, to determine the radiological impact caused by ingestion of food-grade phosphoric acid, and to evaluate the solid waste environmental hazards caused by its application in crop soils. Radiological characterization of raw phosphoric acid, food-grade phosphoric acid, solid waste, and liquid waste was performed by alpha and gamma spectrometry. The (238)U, (234)U, (226)Ra, and (232)Th activity concentrations varied depending on the source of raw phosphoric acid. Decreasing radionuclides activity concentrations in raw phosphoric acids used by the producer of the purified phosphoric acid were observed as follows: Tapira (raw phosphoric acid D) > Catalão (raw phosphoric acids B and C) > Cajati (raw phosphoric acid A). The industrial purification process produces a reduction in radionuclide activity concentrations in food-grade phosphoric acid in relation to raw phosphoric acid produced in plant D and single raw phosphoric acid used in recent years. The most common use of food-grade phosphoric acid is in cola soft drinks, with an average consumption in Brazil of 72 l per person per year. Each liter of cola soft drink contains 0.5 ml of food-grade phosphoric acid, which gives an annual average intake of 36 ml of food-grade phosphoric acid per person. Under these conditions, radionuclide intake through consumption of food-grade phosphoric acid per year per person via cola soft drinks is not hazardous to human health in Brazil

Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

International Nuclear Information System (INIS)

Larsen, R.H.; Bruland, O.S.; Hoff, P.; Alstad, J.; Lindmo, T.; Rofstad, E.K.

1994-01-01

The potential usefulness of α-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) 211 At-TP-3 of different specific activities, (b) 211 At-labeled bovine serum albumin (BSA), (c) free 211 At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, 211 At-BSA or free 211 At. The D o 's were lower for free 211 At than for 211 At-BSA. The survival curves for 211 At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to 211 At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to 211 At-TP-3 treatment was the antigen expression. Cell inactivation after 211 At-TP-3 treatment increased substantially with increasing specific activity of the 211 At-TP-3. At high specific activities, the cytotoxic effect of 211 At-TP-3 was significantly higher than that of 211 At-BSA. In conclusion, 211 At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs

Novel Br-DPQ blue light-emitting phosphors for OLED.

Science.gov (United States)

Dahule, H K; Thejokalyani, N; Dhoble, S J

2015-06-01

A new series of blue light-emitting 2,4-diphenylquinoline (DPQ) substituted blue light-emitting organic phosphors namely, 2-(4-methoxy-phenyl)-4-phenyl-quinoline (OMe-DPQ), 2-(4-methyl-phenyl)-4-phenylquinoline (M-DPQ), and 2-(4-bromo-phenyl)-4-phenylquinoline (Br-DPQ) were synthesized by substituting methoxy, methyl and bromine at the 2-para position of DPQ, respectively by Friedländer condensation of 2-aminobenzophenone and corresponding acetophenone. The synthesized phosphors were characterized by different techniques, e.g., Fourier transform infra-red (FTIR), differential scanning calorimeter (DSC), UV-visible absorption and photoluminescence spectra. FTIR spectra confirms the presence of chemical groups such as C=O, NH, or OH in all the three synthesized chromophores. DSC studies show that these complexes have good thermal stability. Although they are low-molecular-weight organic compounds, they have the potential to improve the stability and operating lifetime of a device made out of these complexes. The synthesized polymeric compounds demonstrate a bright emission in the blue region in the wavelength range of 405-450 nm in solid state. Thus the attachment of methyl, methoxy and bromine substituents to the diphenyl quinoline ring in these phosphors results in colour tuning of the phosphorescence. An electroluminescence (EL) cell of Br-DPQ phosphor was made and its EL behaviour was studied. A brightness-voltage characteristics curve of Br-DPQ cell revealed that EL begins at 400 V and then the brightness increases exponentially with applied AC voltage, while current-voltage (I-V) characteristics revealed that the turn on voltage of the fabricated EL cell was 11 V. Hence this phosphor can be used as a promising blue light material for electroluminescent devices. Copyright © 2014 John Wiley & Sons, Ltd.

[The spectrogram characteristics of organic blue-emissive light-emitting excitated YAG : Ce phosphor].

Science.gov (United States)

Xi, Jian-Fei; Zhang, Fang-Hui; Mu, Qiang; Zhang, Mai-Li

2011-09-01

It is demonstrated that the panchromatic luminescence devices with organic blue-emissive light-emitting was fabricated. This technique used down conversion, which was already popular in inorganic power LEDs to obtain white light emission. A blue OLED device with a configuration of ITO/2T-NATA (30 nm)/AND : TBPe (50 Wt%, 40 nm)/Alq3 (100 nm)/LiF(1 nm)/Al(100 nm) was prepared via vacuum deposition process, and then coated with YAG : Ce phosphor layers of different thicknesses to obtain a controllable and uniform shape while the CIE coordinates were fine tuned. This development not only decreased steps of technics and degree of difficulty, but also applied the mature technology of phosphor. The results showed that steady spectrogram was obtained in the devices with phosphor, with a best performance of a maximum luminance of 13 840 cd x m(-2) which was about 2 times of that of the devices without phosphor; a maximum current efficiency of 17.3 cd x A(-1) was increased more two times more than the devices without phosphor. The emission spectrum could be adjusted by varying the concentration and thickness of the phosphor layers. Absoulte spectrogram of devices was in direct proportion with different driving current corresponding.

A NEW GENERATION OF PARSEC-COLIBRI STELLAR ISOCHRONES INCLUDING THE TP-AGB PHASE

International Nuclear Information System (INIS)

Marigo, Paola; Aringer, Bernhard; Chen, Yang; Dussin, Marco; Nanni, Ambra; Pastorelli, Giada; Rodrigues, Thaíse S.; Trabucchi, Michele; Bladh, Sara; Montalbán, Josefina; Girardi, Léo; Bressan, Alessandro; Rosenfield, Philip; Dalcanton, Julianne; Groenewegen, Martin A. T.; Wood, Peter R.

2017-01-01

We introduce a new generation of PARSEC–COLIBRI stellar isochrones that includes a detailed treatment of the thermally pulsing asymptotic giant branch (TP-AGB) phase, covering a wide range of initial metallicities (0.0001 < Z i < 0.06). Compared to previous releases, the main novelties and improvements are use of new TP-AGB tracks and related atmosphere models and spectra for M and C-type stars; inclusion of the surface H+He+CNO abundances in the isochrone tables, accounting for the effects of diffusion, dredge-up episodes and hot-bottom burning; inclusion of complete thermal pulse cycles, with a complete description of the in-cycle changes in the stellar parameters; new pulsation models to describe the long-period variability in the fundamental and first-overtone modes; and new dust models that follow the growth of the grains during the AGB evolution, in combination with radiative transfer calculations for the reprocessing of the photospheric emission. Overall, these improvements are expected to lead to a more consistent and detailed description of properties of TP-AGB stars expected in resolved stellar populations, especially in regard to their mean photometric properties from optical to mid-infrared wavelengths. We illustrate the expected numbers of TP-AGB stars of different types in stellar populations covering a wide range of ages and initial metallicities, providing further details on the “C-star island” that appears at intermediate values of age and metallicity, and about the AGB-boosting effect that occurs at ages close to 1.6-Gyr for populations of all metallicities. The isochrones are available through a new dedicated web server.

A NEW GENERATION OF PARSEC-COLIBRI STELLAR ISOCHRONES INCLUDING THE TP-AGB PHASE

Energy Technology Data Exchange (ETDEWEB)

Marigo, Paola; Aringer, Bernhard; Chen, Yang; Dussin, Marco; Nanni, Ambra; Pastorelli, Giada; Rodrigues, Thaíse S.; Trabucchi, Michele; Bladh, Sara; Montalbán, Josefina [Dipartimento di Fisica e Astronomia Galileo Galilei, Università di Padova, Vicolo dell’Osservatorio 3, I-35122 Padova (Italy); Girardi, Léo [Osservatorio Astronomico di Padova—INAF, Vicolo dell’Osservatorio 5, I-35122 Padova (Italy); Bressan, Alessandro [SISSA, via Bonomea 365, I-34136 Trieste (Italy); Rosenfield, Philip [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Dalcanton, Julianne [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Groenewegen, Martin A. T. [Koninklijke Sterrenwacht van België, Ringlaan 3, B-1180 Brussels (Belgium); Wood, Peter R. [Research School of Astronomy and Astrophysics, Australian National University, Cotter Road, Weston Creek, ACT 2611 (Australia)

2017-01-20

We introduce a new generation of PARSEC–COLIBRI stellar isochrones that includes a detailed treatment of the thermally pulsing asymptotic giant branch (TP-AGB) phase, covering a wide range of initial metallicities (0.0001 < Z {sub i} < 0.06). Compared to previous releases, the main novelties and improvements are use of new TP-AGB tracks and related atmosphere models and spectra for M and C-type stars; inclusion of the surface H+He+CNO abundances in the isochrone tables, accounting for the effects of diffusion, dredge-up episodes and hot-bottom burning; inclusion of complete thermal pulse cycles, with a complete description of the in-cycle changes in the stellar parameters; new pulsation models to describe the long-period variability in the fundamental and first-overtone modes; and new dust models that follow the growth of the grains during the AGB evolution, in combination with radiative transfer calculations for the reprocessing of the photospheric emission. Overall, these improvements are expected to lead to a more consistent and detailed description of properties of TP-AGB stars expected in resolved stellar populations, especially in regard to their mean photometric properties from optical to mid-infrared wavelengths. We illustrate the expected numbers of TP-AGB stars of different types in stellar populations covering a wide range of ages and initial metallicities, providing further details on the “C-star island” that appears at intermediate values of age and metallicity, and about the AGB-boosting effect that occurs at ages close to 1.6-Gyr for populations of all metallicities. The isochrones are available through a new dedicated web server.

TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population

Directory of Open Access Journals (Sweden)

M.A.C. Smith

2007-11-01

Full Text Available TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex diseases. TP53 codon 72 (TP53:72 polymorphism was investigated in 383 individuals aged 66 to 97 years in a cohort from a Brazilian Elderly Longitudinal Study. We investigated allele frequency, genotype distribution and allele association with morbidities such as cardiovascular disease, type II diabetes, obesity, neoplasia, low cognitive level (dementia, and depression. We also determined the association of this polymorphism with serum lipid fractions and urea, creatinine, albumin, fasting glucose, and glycated hemoglobin levels. DNA was isolated from blood cells, amplified by PCR using sense 5'-TTGCCGTCCCAAGCAATGGATGA-3' and antisense 5'-TCTGGGAAGGGACAGAAGATGAC-3' primers and digested with the BstUI enzyme. This polymorphism is within exon 4 at nucleotide residue 347. Descriptive statistics, logistic regression analysis and Student t-test using the multiple comparison test were used. Allele frequencies, R (Arg = 0.69 and P (Pro = 0.31, were similar to other populations. Genotype distributions were within Hardy-Weinberg equilibrium. This polymorphism did not show significant association with any age-related disease or serum variables. However, R allele carriers showed lower HDL levels and a higher frequency of cardiovascular disease than P allele subjects. These findings may help to elucidate the physiopathological role of TP53:72 polymorphism in Brazilian elderly people.

TL process in europium doped alkaline earth sulphate phosphors- a review

International Nuclear Information System (INIS)

Bhatt, B.C.

2003-01-01

CaSO 4 doped with the rare earth (RE) ion dysprosium or thulium is used routinely as a thermoluminescent dosimeter (TLD) to monitor personal exposure to x- and γ-radiation. The CaSO 4 :Eu phosphor is potentially important for radio photoluminescence (RPL) and ultraviolet (UV) dosimetry. Eu 3+ → Eu 2+ conversion is suggested to play a pivotal role in UV and γ-ray induced thermoluminescence. However, there is disagreement among different workers on the mechanism of gamma and UV induced TL in this phosphor system. This paper will review the work reported on CaSO 4 :Eu and make effects to project overall picture on this phosphor system. (author)

Differences among total and in vitro digestible phosphorus content of meat and milk products.

Science.gov (United States)

Karp, Heini; Ekholm, Päivi; Kemi, Virpi; Hirvonen, Tero; Lamberg-Allardt, Christel

2012-05-01

Meat and milk products are important sources of dietary phosphorus (P) and protein. The use of P additives is common both in processed cheese and meat products. Measurement of in vitro digestible phosphorus (DP) content of foods may reflect absorbability of P. The objective of this study was to measure both total phosphorus (TP) and DP contents of selected meat and milk products and to compare amounts of TP and DP and the proportion of DP to TP among different foods. TP and DP contents of 21 meat and milk products were measured by inductively coupled plasma optical emission spectrometry (ICP-OES). In DP analysis, samples were digested enzymatically, in principle, in the same way as in the alimentary canal before the analyses. The most popular national brands of meat and milk products were chosen for analysis. The highest TP and DP contents were found in processed and hard cheeses; the lowest, in milk and cottage cheese. TP and DP contents in sausages and cold cuts were lower than those in cheeses. Chicken, pork, beef, and rainbow trout contained similar amounts of TP, but slightly more variation was found in their DP contents. Foods containing P additives have a high content of DP. Our study confirms that cottage cheese and unenhanced meats are better choices than processed or hard cheeses, sausages, and cold cuts for chronic kidney disease patients, based on their lower P-to-protein ratios and sodium contents. The results support previous findings of better P absorbability in foods of animal origin than in, for example, legumes. Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.

Science.gov (United States)

Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit; Wang, Jiping; Jasser, Samar; McDowell, Christina; Kadara, Humam; Zhang, Jiexin; Wang, Jing; William, William N; Lee, J Jack; Nguyen, Minh Ly; Pai, Sara I; Walline, Heather M; Shin, Dong M; Ferris, Robert L; Carey, Thomas E; Myers, Jeffrey N; Pickering, Curtis R

2018-01-01

Human immunodeficiency virus-infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with those of HNSCC patients without a human immunodeficiency virus (HIV) infection. The reasons for these differences are not clear, and molecular differences between HIV-related HNSCC and non-HIV-related HNSCC may exist. This study compared the mutational patterns of HIV-related HNSCC and non-HIV-related HNSCC. The DNA of 20 samples of HIV-related HNSCCs and 32 samples of non-HIV-related HNSCCs was sequenced. DNA libraries covering exons of 18 genes frequently mutated in HNSCC (AJUBA, CASP8, CCND1, CDKN2A, EGFR, FAT1, FBXW7, HLA-A, HRAS, KEAP1, NFE2L2, NOTCH1, NOTCH2, NSD1, PIK3CA, TGFBR2, TP53, and TP63) were prepared and sequenced on an Ion Personal Genome Machine sequencer. DNA sequencing data were analyzed with Ion Reporter software. The human papillomavirus (HPV) status of the tumor samples was assessed with in situ hybridization, the MassARRAY HPV multiplex polymerase chain reaction assay, and p16 immunostaining. Mutation calls were compared among the studied groups. HIV-related HNSCC revealed a distinct pattern of mutations in comparison with non-HIV-related HNSCC. TP53 mutation frequencies were significantly lower in HIV-related HNSCC. Mutations in HIV+ patients tended to be TpC>T nucleotide changes for all mutated genes but especially for TP53. HNSCC in HIVIIs presents a distinct pattern of genetic mutations, particularly in the TP53 gene. HIV-related HNSCC may have a distinct biology, and an effect of the HIV virus on the pathogenesis of these tumors should not be ruled out. Cancer 2018;124:84-94. © 2017 American Cancer Society. © 2017 American Cancer Society.

Determination of the activity concentration of 230Th in phosphoric acids produced in Brazil

International Nuclear Information System (INIS)

Taddei, M.H.T.; Ferreira, M.T.; Fukuma, H.T.; Xavier, T.T.; Sousa, F.V.T.S.

2017-01-01

The high uranium phosphate rock from Itataia, Brazil, was processed using the wet route in the dihydrate system to manufacture phosphoric acid. The uranium contained in phosphoric acid was recovered by the solvent extraction technique. The distribution of the long half-life radionuclides from the decay series of 238 U and 232 Th were evaluated in these processes. The 26 Ra, 228 Ra and 210 Pb radionuclides were found predominantly in phosphogypsum, while the isotopes of 228 Th, 230 Th and 232 Th predominated in phosphoric acid after extracting uranium. The main concern in the commercialization of phosphoric acid that will be produced in the Itataia plant is in relation to the content of 230 Th. This work determined the content of these radionuclides in phosphoric acid from different locations in the country in order to compare

Clinical performance evaluation of total protein measurement by digital refractometry and characterization of non-protein solute interferences.

Science.gov (United States)

Hunsaker, Joshua J H; Wyness, Sara P; Snow, Taylor M; Genzen, Jonathan R

2016-12-01

Refractometric methods to measure total protein (TP) in serum and plasma specimens have been replaced by automated biuret methods in virtually all routine clinical testing. A subset of laboratories, however, still report using refractometry to measure TP in conjunction with serum protein electrophoresis. The objective of this study was therefore to conduct a modern performance evaluation of a digital refractometer for TP measurement. Performance evaluation of a MISCO Palm Abbe™ digital refractometer was conducted through device familiarization, carryover, precision, accuracy, linearity, analytical sensitivity, analytical specificity, and reference interval verification. Comparison assays included a manual refractometer and an automated biuret assay. Carryover risk was eliminated using a demineralized distilled water (ddH 2 O) wash step. Precision studies demonstrated overall imprecision of 2.2% CV (low TP pool) and 0.5% CV (high TP pool). Accuracy studies demonstrated correlation to both manual refractometry and the biuret method. An overall positive bias (+5.0%) was observed versus the biuret method. On average, outlier specimens had an increased triglyceride concentration. Linearity was verified using mixed dilutions of: a) low and high concentration patient pools, or b) albumin-spiked ddH 2 O and high concentration patient pool. Decreased recovery was observed using ddH 2 O dilutions at low TP concentrations. Significant interference was detected at high concentrations of glucose (>267 mg/dL) and triglycerides (>580 mg/dL). Current laboratory reference intervals for TP were verified. Performance characteristics of this digital refractometer were validated in a clinical laboratory setting. Biuret method remains the preferred assay for TP measurement in routine clinical analyses.

Boron-Containing Red Light-Emitting Phosphors And Light Sources Incorporating The Same

Science.gov (United States)

Srivastava, Alok Mani; Comanzo, Holly Ann; Manivannan, Venkatesan

2006-03-28

A boron-containing phosphor comprises a material having a formula of AD1-xEuxB9O16, wherein A is an element selected from the group consisting of Ba, Sr, Ca, Mg, and combinations thereof; D is at least an element selected from the group consisting of rare-earth metals other than europium; and x is in the range from about 0.005 to about 0.5. The phosphor is used in a blend with other phosphors in a light source for generating visible light with a high color rendering index.

Eu/Tb ions co-doped white light luminescence Y2O3 phosphors

International Nuclear Information System (INIS)

Tu Dong; Liang Yujun; Liu Rong; Li Daoyi

2011-01-01

Y 2 O 3 :Eu 3+ , Tb 3+ phosphors with white emission are prepared with different doping concentration of Eu 3+ and Tb 3+ ions and synthesizing temperatures from 750 to 950 deg. C by the co-precipitation method. The resulted phosphors were characterized by X-ray diffraction (XRD) and photoluminescence (PL) spectroscopy. The results of XRD indicate that the crystallinity of the synthesized samples increases with enhancing the firing temperature. The photoluminescence spectra indicate the Eu 3+ and Tb 3+ co-doped Y 2 O 3 phosphors show five main emission peaks: three at 590, 611 and 629 nm originate from Eu 3+ and two at 481 and 541 nm originate from Tb 3+ , under excitation of 250-320 nm irradition. The white light luminescence color could be changed by varying the excitation wavelength. Different concentrations of Eu 3+ and Tb 3+ ions were induced into the Y 2 O 3 lattice and the energy transfer from Tb 3+ →Eu 3+ ions in these phosphors was found. The Commission International de l'Eclairage (CIE) chromaticity shows that the Y 2 O 3 :Eu 3+ , Tb 3+ phosphors can obtain an intense white emission. - Highlights: → Novel phosphors Y 2 O 3 :Eu 3+ , Tb 3+ have been synthesized by co-precipitation method. → Samples emit white light with excellent color coordinates under UV excitation. → Luminescence color could be changed by varying the excitation wavelength. → Energy transfer from Tb 3+ →Eu 3+ ions in these phosphors was found.

Phosphors containing boron and metals of Group IIIA and IIIB

Science.gov (United States)

Setlur, Anant Achyut; Srivastava, Alok Mani; Comanzo, Holly Ann; Manivannan, Venkatesan

2006-10-31

A phosphor comprises: (a) at least a first metal selected from the group consisting of yttrium and elements of lanthanide series other than europium; (b) at least a second metal selected from the group consisting of aluminum, gallium, indium, and scandium; (c) boron; and (d) europium. The phosphor is used in light source that comprises a UV radiation source to convert UV radiation to visible light.

Thermoluminescence dosimetric characteristics of thulium doped ZnB{sub 2}O{sub 4} phosphor

Energy Technology Data Exchange (ETDEWEB)

Annalakshmi, O. [Radiological Safety Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Jose, M.T., E-mail: mtj@igcar.gov.in [Radiological Safety Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Madhusoodanan, U. [Radiological Safety Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Subramanian, J. [Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai (India); Venkatraman, B. [Radiological Safety Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Amarendra, G. [Materials Physics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Mandal, A.B. [Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai (India)

2014-02-15

Polycrystalline powder samples of rare earth doped Zinc borates were synthesized by high temperature solid state diffusion technique. Dosimetric characteristics of the phosphor like thermoluminescence glow curve, TL emission spectra, dose–response, fading studies, reproducibility and reusability studies were carried out on the synthesized phosphors. Among the different rare earth doped phosphors, thulium doped zinc borate was found to have a higher sensitivity. Hence detailed dosimetric characteristics of this phosphor were carried out. It is observed that the dose–response is linear from 10 mGy to 10{sup 3} Gy in this phosphor. EPR measurements were carried out on unirradiated, gamma irradiated and annealed phosphors to identify the defect centers responsible for thermoluminescence. A TL model is proposed based on the EPR studies in these materials. Kinetic parameters were evaluated for the dosimetric peaks using various methods. The experimental results show that this phosphor can have potential applications in radiation dosimetry applications. -- Highlights: • Polycrystalline powder samples of rare earth doped zinc borates were synthesized. • Thulium was observed to be the most efficient dopant in ZnB{sub 2}O{sub 4} lattice. • TL intensity of the dosimetric peak is around 20 times that of TLD-100. • Based on EPR studies a TL mechanism is proposed in zinc borate. • Deconvolution of the glow curve carried out.

Transport of phosphoric acid through supported liquid membrane

International Nuclear Information System (INIS)

Zayzafoon, G.; Yassine, T.; Baidoun, R.

2003-01-01

The transport of phosphhoric acid through liquid membranes of amylalkohol, 1-octanol and 2-octanol was studied. It was found that phosphoric acid is transfered from feed side to strip side and the transport increased with the concentration of phosphoric acid up to 5M. The permeability in each membrane was determined for 5M phosphoic acid. It was found that the permeability values are 1.45 x 10 1 0 m 2 s 1 for amylakohol and ∼ 1x10 1 0 m 2 s 1 for each of 1-octanol and 2-octanol

Transport and Retention of Nitrogen, Phosphorus and Carbon in North America’s Largest River Swamp Basin, the Atchafalaya River Basin

Directory of Open Access Journals (Sweden)

Y. Jun Xu

2013-04-01

Full Text Available Floodplains and river corridor wetlands may be effectively managed for reducing nutrients and carbon. However, our understanding is limited to the reduction potential of these natural riverine systems. This study utilized the long-term (1978–2004 river discharge and water quality records from an upriver and a downriver location of the Atchafalaya River to quantify the inflow, outflow, and inflow–outflow mass balance of total Kjeldahl nitrogen (TKN = organic nitrogen + ammonia nitrogen, nitrate + nitrite nitrogen (NO3 + NO2, total phosphorous (TP, and total organic carbon (TOC through the largest river swamp basin in North America. The study found that, over the past 27 years, the Atchafalaya River Basin (ARB acted as a significant sink for TKN (annual retention: 24%, TP (41%, and TOC (12%, but a source for NO3 + NO2 nitrogen (6%. On an annual basis, ARB retained 48,500 t TKN, 16,900 t TP, and 167,100 t TOC from the river water. The retention rates were closely and positively related to the river discharge with highs during the winter and spring and lows in the late summer. The higher NO3 + NO2 mass outflow occurred throughout spring and summer, indicating an active role of biological processes on nitrogen as water and air temperatures in the basin rise.

Photoluminescence in Sm3+ doped Ba2P2O7 phosphor prepared by solution combustion method

Science.gov (United States)

Ghawade, Sonal P.; Deshmukh, Kavita A.; Dhoble, S. J.; Deshmukh, Abhay D.

2018-05-01

In this paper, Sm3+ doped Ba2P2O7 phosphors were synthesized via a Solution combustion method. The crystal structure of the phosphor was characterized by XRD. Orange-red emission was observed from these phosphors under near-ultraviolet (UV) excitation at 404 nm. The luminescence properties of the obtained phosphors were characterized by different techniques. The Ba2P2O7:Sm3+ phosphor can be efficiently excited by near-UV and blue light, and their emission spectrum consists of three emission peaks, at 564, 602, and 646 nm, respectively. Based on the results, the as prepared Ba2P2O7:Sm3+ phosphors are promising orange-red-emitting phosphors exhibit great potential may be applicable as a spectral convertor in c-Si solar cell to enhance the efficiency of solar cell in future.

Significance of TP53 mutation in Wilms tumors with diffuse anaplasia : A report from the Children's Oncology Group

NARCIS (Netherlands)

Ooms, Ariadne H A G; Gadd, Samantha; Gerhard, Daniela S.; Smith, Malcolm A.; Guidry Auvil, Jaime M.; Meerzaman, Daoud; Chen, Qing Rong; Hsu, Chih Hao; Yan, Chunhua; Nguyen, Cu; Hu, Ying; Ma, Yussanne; Zong, Zusheng; Mungall, Andrew J.; Moore, Richard A.; Marra, Marco A.; Huff, Vicki; Dome, Jeffrey S.; Chi, Yueh Yun; Tian, Jing; Geller, James I.; Mullighan, Charles G.; Ma, Jing; Wheeler, David A.; Hampton, Oliver A.; Walz, Amy L.; Van Den Heuvel-Eibrink, Marry M.; De Krijger, Ronald R.; Ross, Nicole; Gastier-Foster, Julie M.; Perlman, Elizabeth J.

2016-01-01

Purpose: To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs). Experimental Design: All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were analyzed for TP53 mutations and copy loss. Integrative genomic analysis was

Activated phosphors having matrices of yttrium-transition metal compound

International Nuclear Information System (INIS)

De Kalb, E.L.; Fassel, V.A.

1975-01-01

A method is described for preparing a phosphor composition containing a lanthanide activator element with a host matrix having a transition element as a major component. The host matrix is composed of certain rare earth phosphates or vanadates such as YPO 4 with a portion of the rare earth replaced with one or more of the transition elements. On x-ray or other electromagnetic excitation, trace lanthanide impurities or additives within the phosphor are spectrometrically determined from their characteristic luminescence

Nutrient bioassimilation capacity of aquacultured oysters: quantification of an ecosystem service.

Science.gov (United States)

Higgins, Colleen B; Stephenson, Kurt; Brown, Bonnie L

2011-01-01

Like many coastal zones and estuaries, the Chesapeake Bay has been severely degraded by cultural eutrophication. Rising implementation costs and difficulty achieving nutrient reduction goals associated with point and nonpoint sources suggests that approaches supplemental to source reductions may prove useful in the future. Enhanced oyster aquaculture has been suggested as one potential policy initiative to help rid the Bay waters of excess nutrients via harvest of bioassimilated nutrients. To assess this potential, total nitrogen (TN), total phosphorous (TP), and total carbon (TC) content were measured in oyster tissue and shell at two floating-raft cultivation sites in the Chesapeake Bay. Models were developed based on the common market measurement of total length (TL) for aquacultured oysters, which was strongly correlated to the TN (R2 = 0.76), TP (R2 = 0.78), and TC (R2 = 0.76) content per oyster tissue and shell. These models provide resource managers with a tool to quantify net nutrient removal. Based on model estimates, 10(6) harvest-sized oysters (76 mm TL) remove 132 kg TN, 19 kg TP, and 3823 kg TC. In terms of nutrients removed per unit area, oyster harvest is an effective means of nutrient removal compared with other nonpoint source reduction strategies. At a density of 286 oysters m(-2), assuming no mortality, harvest size nutrient removal rates can be as high as 378 kg TN ha(-1), 54 kg TP ha(-1), and 10,934 kg TC ha(-1) for 76-mm oysters. Removing 1 t N from the Bay would require harvesting 7.7 million 76-mm TL cultivated oysters.

Luminescence properties of CdSiO3:Mn2+ phosphor

International Nuclear Information System (INIS)

Lei Bingfu; Liu Yingliang; Ye Zeren; Shi Chunshan

2004-01-01

A novel long-lasting phosphor CdSiO 3 :Mn 2+ is reported in this paper. The Mn 2+ -doped CdSiO 3 phosphor emits orange light with CIE chromaticity coordinates x=0.5814 and y=0.4139 under 254 nm UV light excitation. In the emission spectrum of 1% Mn 2+ -doped CdSiO 3 phosphor, there is a broad emission band centered at 575 nm which can be attributed to the spin-forbidden transition of the d-orbital electron associated with the Mn 2+ ion. The phosphorescence can be seen by the naked eyes in the dark clearly even after the 254 nm UV irradiation have been removed for about 1 h. The mechanism of the origin of the long-lasting phosphorescence was discussed using the thermoluminescence curves

TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia.

Science.gov (United States)

Wegert, Jenny; Vokuhl, Christian; Ziegler, Barbara; Ernestus, Karen; Leuschner, Ivo; Furtwängler, Rhoikos; Graf, Norbert; Gessler, Manfred

2017-10-01

TP53 mutations have been associated with anaplasia in Wilms tumour, which conveys a high risk for relapse and fatal outcome. Nevertheless, TP53 alterations have been reported in no more than 60% of anaplastic tumours, and recent data have suggested their presence in tumours that do not fulfil the criteria for anaplasia, questioning the clinical utility of TP53 analysis. Therefore, we characterized the TP53 status in 84 fatal cases of Wilms tumour, irrespective of histological subtype. We identified TP53 alterations in at least 90% of fatal cases of anaplastic Wilms tumour, and even more when diffuse anaplasia was present, indicating a very strong if not absolute coupling between anaplasia and deregulation of p53 function. Unfortunately, TP53 mutations do not provide additional predictive value in anaplastic tumours since the same mutation rate was found in a cohort of non-fatal anaplastic tumours. When classified according to tumour stage, patients with stage I diffuse anaplastic tumours still had a high chance of survival (87%), but this rate dropped to 26% for stages II-IV. Thus, volume of anaplasia or possible spread may turn out to be critical parameters. Importantly, among non-anaplastic fatal tumours, 26% had TP53 alterations, indicating that TP53 screening may identify additional cases at risk. Several of these non-anaplastic tumours fulfilled some criteria for anaplasia, for example nuclear unrest, suggesting that such partial phenotypes should be under special scrutiny to enhance detection of high-risk tumours via TP53 screening. A major drawback is that these alterations are secondary changes that occur only later in tumour development, leading to striking intratumour heterogeneity that requires multiple biopsies and analysis guided by histological criteria. In conclusion, we found a very close correlation between histological signs of anaplasia and TP53 alterations. The latter may precede development of anaplasia and thereby provide diagnostic value

Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer.

Directory of Open Access Journals (Sweden)

Jian Chen

Full Text Available Retinoblastoma binding protein 6 (RBBP6 plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of RBBP6 expression in colon cancer is unknown; in particular, the prognostic value of RBBP6 combined with TP53 expression has not been explored. Therefore, quantitative real-time PCR and western blot analyses were performed to detect RBBP6 expression in colon cancer tissues. RBBP6 and TP53 expression were assessed by immunohistochemistry in a tissue microarray format, in which the primary colon cancer tissue was paired with noncancerous tissue. Tissue specimens were obtained from 203 patients. We found that RBBP6 was overexpressed in colon tumorous tissues and was significantly associated with clinical stage, depth of tumor invasion, lymph node metastasis (LNM, distant metastasis, and histologic grade. Further studies revealed that a corresponding correlation between RBBP6 overexpression and mutant TP53 was evident in colon cancer (r = 0.450; P<0.001. RBBP6 expression was an independent prognostic factor for overall survival (OS and disease free survival (DFS. Interestingly, patients with tumors that had both RBBP6 overexpression and mutant TP53 protein accumulation relapsed and died within a significantly short period after surgery (P<0.001. Multivariate analysis showed that patients with LNM and patients with both RBBP6- and TP53-positive tumors had extremely poor OS (HR 6.75; 95% CI 2.63-17.35; P<0.001 and DFS (HR 8.08; 95% CI 2.80-23.30; P<0.001. These clinical findings indicate that the assessment of both RBBP6 and mutant TP53 expression will be helpful in predicting colon cancer prognosis.

Photoluminescence properties of Eu(3+)/ Sm(3+) activated CaZr4(PO4)6 phosphors.

Science.gov (United States)

Nair, Govind B; Dhoble, S J

2016-09-01

Solid state reaction method was employed for the synthesis of a series of CaZr4(PO4)6: Eu(3+)/Sm(3+) phosphors. The red-emitting CaZr4(PO4)6:Eu(3+) phosphors can be efficiently excited at 396 nm and thereby, exhibit a strong red luminescence predominantly corresponding to the electric dipole transition at 615 nm. Under 405 nm excitation, CaZr4(PO4)6:Sm(3+) phosphors display orange emission with color temperatures approximately around 2200 K. The acquired results reveal that CaZr4(PO4)6: RE(3+) (RE = Eu, Sm) phosphors could be potential candidates for red and orange emitting phosphor, respectively, for UV/blue-pump LEDs.

Instense red phosphors for UV light emitting diode devices.

Science.gov (United States)

Cao, Fa-Bin; Tian, Yan-Wen; Chen, Yong-Jie; Xiao, Lin-Jiu; Liu, Yun-Yi

2010-03-01

Ca(x)Sr1-x-1.5y-0.5zMoO4:yEu3+ zNa+ red phosphors were prepared by solid-state reaction using Na+ as charge supply for LEDs (light emitting diodes). The content of charge compensator, Ca2+ concentration, synthesis temperature, reaction time, and Eu3+ concentration were the keys to improving the properties of luminescence and crystal structure of red phosphors. The photoluminescence spectra shows the red phosphors are effectively excited at 616 nm by 311 nm, 395 nm, and 465 nm light. The wavelengths of 395 and 465 nm nicely match the widely applied emission wavelengths of ultraviolet or blue LED chips. Its chromaticity coordinates (CIE) are calculated to be x = 0.65, y = 0.32. Bright red light can be observed by the naked eye from the LED-based Ca0.60Sr0.25MoO4:0.08Eu3+ 0.06Na+.

Near-infrared dyes and upconverting phosphors as biomolecule labels and probes

Science.gov (United States)

Patonay, Gabor; Strekowski, Lucjan; Nguyen, Diem-Ngoc; Seok, Kim Jun

2007-02-01

Near-Infrared (NIR) absorbing chromophores have been used in analytical and bioanalytical chemistry extensively, including for determination of properties of biomolecules, DNA sequencing, immunoassays, capillary electrophoresis (CE) separations, etc. The major analytical advantages of these dyes are low background interference and high molar absorptivities. NIR dyes have additional advantages due to their sensitivity to microenvironmental changes. Spectral changes induced by the microenvironment are not desirable if the labels are used as a simple reporting group, e.g., during a biorecognition reaction. For these applications upconverting phosphors seem to be a better choice. There are several difficulties in utilizing upconverting phosphors as reporting labels. These are: large physical size, no reactive groups and insolubility in aqueous systems. This presentation will discuss how these difficulties can be overcome for bioanalytical and forensic applications. During these studies we also have investigated how to reduce physical size of the phosphor by simple grinding without losing activity and how to attach reactive moiety to the phosphor to covalently bind to the biomolecule of interest. It has to be emphasized that the described approach is not suitable for medical applications and the results of this research are not applicable in medical applications. For bioanalytical and forensic applications upconverting phosphors used as reporting labels have several advantages. They are excited with lasers that are red shifted respective to phosphorescence, resulting in no light scatter issues during detection. Also some phosphors are excited using eye safe lasers. In addition energy transfer to NIR dyes is possible, allowing detection schemes using donor-acceptor pairs. Data is presented to illustrate the feasibility of this phenomenon. If microenvironmental sensitivity is required, then specially designed NIR dyes can be used as acceptor labels. Several novel dyes

Why do proton conducting polybenzimidazole phosphoric acid membranes perform well in high-temperature PEM fuel cells?

Science.gov (United States)

Melchior, Jan-Patrick; Majer, Günter; Kreuer, Klaus-Dieter

2016-12-21

Transport properties and hydration behavior of phosphoric acid/(benz)imidazole mixtures are investigated by diverse NMR techniques, thermogravimetric analysis (TGA) and conductivity measurements. The monomeric systems can serve as models for phosphoric acid/poly-benzimidazole membranes which are known for their exceptional performance in high temperature PEM fuel cells. 1 H- and 31 P-NMR data show benzimidazole acting as a strong Brønsted base with respect to neat phosphoric acid. Since benzimidazole's nitrogens are fully protonated with a low rate for proton exchange with phosphate species, proton diffusion and conduction processes must take place within the hydrogen bond network of phosphoric acid only. The proton exchange dynamics between phosphate and benzimidazole species pass through the intermediate exchange regime (with respect to NMR line separations) with exchange times being close to typical diffusion times chosen in PFG-NMR diffusion measurements (ms regime). The resulting effects, as described by the Kärger equation, are included into the evaluation of PFG-NMR data for obtaining precise proton diffusion coefficients. The highly reduced proton diffusion coefficient within the phosphoric acid part of the model systems compared to neat phosphoric acid is suggested to be the immediate consequence of proton subtraction from phosphoric acid. This reduces hydrogen bond network frustration (imbalance of the number of proton donors and acceptors) and therefore also the rate of structural proton diffusion, phosphoric acid's acidity and hygroscopicity. Reduced water uptake, shown by TGA, goes along with reduced electroosmotic water drag which is suggested to be the reason for PBI-phosphoric acid membranes performing better in fuel cells than other phosphoric-acid-containing electrolytes with higher protonic conductivity.

Enhanced red emission of LaVO4:Eu3+ phosphors by Li-doping

International Nuclear Information System (INIS)

Park, Sung Wook; Yang, Hyun Kyoung; Chung, Jong Won; Moon, Byung Kee; Choi, Byung Chun; Jeong, Jung Hyun; Jang, Ki Wan; Lee, Ho Sueb; Yi, Soung Soo

2010-01-01

LaVO 4 phosphors were synthesized by using a solid state reaction, and were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM) and photoluminescence (PL). The XRD patterns of the Li-doped LaVO 4 :Eu 3+ powder phosphors revealed a mixture of tetragonal and monoclinic phases. The tetragonal phase of the LaVO 4 :Eu 3+ phosphor showed a higher PL intensity than the monoclinic one, despite the presence of both monoclinic and tetragonal structures. The Li-doped LaVO 4 :Eu 3+ powder phosphors absorbed strongly at 396 nm and exhibited strong red emission at approximately 619.5 nm due to the 5 D 0 → 7 F 2 transition. The incorporation of Li + ions into the LaVO 4 :Eu 3+ powder can lead to a remarkable increase in photoluminescence. The enhanced luminescence is attributed to the incorporation of Li + ions that may act as a sensitizers for effective energy transfer. This phosphor has promising applications in near-UV light-emitting diodes(LEDs).

UV excited downconversion luminescence properties of Eu3+: NaZnPO4 phosphors

Science.gov (United States)

Mukhopadhyay, Lakshmi; Rai, Vineet Kumar

2018-05-01

The structural and optical properties of Eu3+: NaZnPO4 phosphors prepared by chemical coprecipitation method have been studied. The phase formation and morphology of the phosphors have been confirmed by the X-ray diffraction (XRD) and Field emission scanning electron microscopy (FESEM) analysis. The downconversion emission spectra upon 392 nm excitation exhibit five emission bands centred at ˜ 575 nm, ˜ 590 nm, ˜ 612 nm, ˜ 660 nm and ˜ 702 nm corresponding to the 5D0→7F0, 5D0→7F1, 5D0→7F2, 5D0→7F3 and 5D0→7F4 transitions of Eu3+ ions respectively. The observed downconversion emission peaks can be explained with the help of suitable energy level diagram. The CIE chromaticity diagram shows the purity of the emitted colour from the prepared phosphors. The present phosphors emit in intense red region which shows the applicability of the phosphors in red light emitting display devices.

Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients

DEFF Research Database (Denmark)

Dufour, Annika; Palermo, Giuseppe; Zellmeier, Evelyn

2013-01-01

In chronic lymphocytic leukemia (CLL) patients, disruptions of the TP53 tumor suppressor pathway by 17p13 deletion (del17p), somatic TP53 mutations, or downregulation of microRNA-34a have been associated with a poor prognosis. So far, the impact of the various TP53 defects has not been evaluated ...

Image File - TP Atlas | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available ption of data contents Network diagrams (in PNG format) for each project. One project has one pathway file o...List Contact us TP Atlas Image File Data detail Data name Image File DOI 10.18908/lsdba.nbdc01161-004 Descri

Structural optimization for remote white light-emitting diodes with quantum dots and phosphor: packaging sequence matters.

Science.gov (United States)

Xie, Bin; Chen, Wei; Hao, Junjie; Wu, Dan; Yu, Xingjian; Chen, Yanhua; Hu, Run; Wang, Kai; Luo, Xiaobing

2016-12-26

White light-emitting diodes (WLEDs) with quantum dots (QDs) and phosphor have attracted tremendous attentions due to their excellent color rendering ability. In the packaging process, QDs layer and phosphor-silicone layer tend to be separated to reduce the reabsorption losses, and to maintain the stability of QDs surface ligands. This study investigated the packaging sequence between QDs and phosphor on the optical and thermal performances of WLEDs. The output optical power and PL spectra were measured and analyzed, and the temperature fields were simulated and validated experimentally by infrared thermal imager. It was found that when driven by 60 mA, the QDs-on-phosphor type WLEDs achieved luminous efficiency (LE) of 110 lm/W, with color rendering index (CRI) of Ra = 92 and R9 = 80, while the phosphor-on-QDs type WLEDs demonstrated lower LE of 68 lm/W, with Ra = 57 and R9 = 24. Moreover, the QDs-on-phosphor type WLEDs generated less heat than that of another, consequently the highest temperature in the QDs-on-phosphor type was lower than another, and the temperature difference can reach 12.3°C. Therefore, in terms of packaging sequence, the QDs-on-phosphor type is an optimal packaging architecture for higher optical efficiency, better color rendering ability and lower device temperature.

Investigation of the effect of engine lubricant oil on remote temperature sensing using thermographic phosphors

Energy Technology Data Exchange (ETDEWEB)

Abou Nada, Fahed, E-mail: Fahed.Abou_Nada@forbrf.lth.se; Aldén, Marcus; Richter, Mattias

2016-11-15

Phosphor thermometry, a remote temperature sensing technique, is widely implemented to measure the temperature of different combustion engines components. The presence of engine lubricant can influence the behavior of the applied sensor materials, known as thermographic phosphors, and thus leading to erroneous temperature measurements. The effect of two engine lubricants on decay times originating from six different thermographic phosphors was investigated. The decay time of each thermographic phosphor was investigated as a function of lubricant/phosphor mass ratio. Tests were conducted at temperatures around 293 K and 376 K for both lubricants. The investigations revealed that ZnO:Zn and ZnS:Ag are the only ones that exhibit a change of the decay time as function of the lubricant/phosphor mass ratio. While the remaining thermographic phosphors, namely BaMg{sub 2}Al{sub 16}O{sub 27}:Eu (BAM), Al{sub 2}O{sub 3}-coated BaMg{sub 2}Al{sub 16}O{sub 27}:Eu, La{sub 2}O{sub 2}S:Eu, Mg{sub 3}F{sub 2}GeO{sub 4}:Mn, displayed no sensitivity of their characteristic decay time on to the presence of lubricant on the porous coating. Biases in the calculated temperature are to be expected if the utilized thermographic phosphor displays decay time sensitivity to the existence of the engine lubricant within the sensor. Such distortions are concealed and can occur undetected leading to false temperature readings for the probed engine component.

Rare Earth Free Zn3V2O8 Phosphor with Controlled Microstructure and Its Photocatalytic Activity

Directory of Open Access Journals (Sweden)

Hom Nath Luitel

2013-01-01

Full Text Available Microsphere of rare earth free phosphor, Zn3V2O8, with broadband yellowish white emission was synthesized by combustion route and compared with the hydrothermal, sol-gel, and solid state reaction methods. The phosphor samples were characterized by X-ray diffraction and scanning electron microscopy. UV-visible absorption and photoluminescence (PL emission and excitation spectra were investigated for these phosphors. Zn3V2O8 phosphor containing 10 mol% of H3BO3 flux exhibited enhanced PL emission showing broadband from 450 nm to 750 nm. Effect of stoichiometry of Zn and V on the host lattice and its effect on the PL emission spectra were studied. Series of Mg3V2O8, Ca3V2O8, and Sr3V2O8 phosphors were also synthesized and compared to the Zn3V2O8 phosphor in terms of PL emission and internal quantum yield, and it was found that Zn3V2O8 is the most efficient phosphor among the other phosphors studied with quantum yield of 60%. The visible light irradiated photocatalytic activity of these phosphors was investigated and it was found that the hydrothermal Zn3V2O8 exhibited enhanced activity.

Preparation and Characterization of UV Emitting Fluoride Phosphors for Phototherapy Lamps

Science.gov (United States)

Belsare, P. D.; Moharil, S. V.; Joshi, C. P.; Omanwar, S. K.

2011-10-01

The use of ultraviolet radiation for the treatment of various skin diseases is well known for long time. Phototherapy employs ultraviolet-blue radiation to cure skin diseases. The basis of phototherapy is believed to be the direct interaction of light of certain frequencies with tissue to cause a change in immune response. Currently dermatologists use UV lamps having specific emissions in UV region for treating various skin diseases. The treatment of skin diseases using artificial sources of UV radiation is now well established and more than 50 types of skin diseases are treated by phototherapy. This is an effective treatment for many skin disorders, such as psoriasis, vitiligo, ofujis disease, morphea , scleroderma, cutaneous T-cell lymphoma, lupus erythematosus, hyperbilirubinemia commonly known as infant jaundice, acne vulgaris, This paper reports photoluminescence properties of UV emitting fluoride phosphors prepared by wet chemical method. Emission characteristics of these phosphors are found similar to those of commercial UV lamp phosphors with comparable intensities. The usefulness of UV emitting fluoride phosphor is discussed in the paper.

Process engineering challenges of uranium extraction from phosphoric acid on industrial scale

International Nuclear Information System (INIS)

Mouriya, Govind; Singh, Dhirendra; Nath, A.K.; Majumdar, D.

2014-01-01

Heavy Water Board (HWB) is a constituent unit of the Department of Atomic Energy. One of the diversified activities undertaken by HWB is pursuing exploitation of non-conventional resources for recovery of uranium from wet phosphoric acid being the most prominent one. Amongst the feasible processes for recovery of uranium from phosphoric acid is solvent extraction. Use of in-house solvent produced by HWB, is another key driver. To garner necessary information for developing the industrial scale facilities, the process has been studied in the laboratory scale, mini scale, bench scale at Heavy Water Plant, Talcher. The process was subsequently scaled up to an industrial prototype scale unit and was set up as a Technology Demonstration Plant coupled with a commercial phosphoric acid plant. The plant has successfully processed more than 2 lakh m 3 of wet phosphoric acid and all the parameters including the product, Yellow Cake have been qualified. No adverse effect has been observed in the fertilizer produced. The main characteristics of the process and subsequent process innovations are discussed in this paper. These innovations have been carried out to overcome hurdles faced during commissioning and subsequent operations of the Plant. The innovations include improved pretreatment of the wet phosphoric acid for feeding to the extraction cycle, improved control of the first cycle chemical environment, reducing the strength of the phosphoric acid used for stripping, reducing the number of equipment and machineries, alteration in solvent composition used in the first and second cycle in the solvent extraction units of the plant. (author)

Study of phase transformation processes in steel after phosphor ion implantation and following thermal treatment

International Nuclear Information System (INIS)

Zhetbaev, A.K.; Vereshchak, N.F.; Satpaev, K.K.; Dosmagambetov, T.D.; Serikbaeva, Z.T.

1999-01-01

In the paper process of phase transformation after phosphor ion implantation in steel-45 and annealing in vacuum at 1000 deg C and irradiation by various doses of phosphor ions with energy 100 keV an accelerator are researched by conversion electron method. The phosphor overall solubility in iron is equal 4.53 %. Implantation dose below 6·10 17 ions/cm 2 allows increase phosphor ions content in implantation region to 35 %. Therefore, iron phosphides (Fe 3 P, Fe 2 P and Fe P) forming are possible. (author)

Synthesis and complex forming property of phosphor acid derivatives

International Nuclear Information System (INIS)

Babaev, B.N.

2004-01-01

Full text:With the aim to get new effective and selective extra gents of noble and non-ferrous metals from acid solution and industrial sewage, research of the dependence of 'structure effectiveness' the various phosphor acid derivatives with logical changeable structure (thio phosphor acids, derivatives of dialkoxythiophosphor, O-alkyl-methylphosphon, alkylphenylphosphon, diphenylphosphine acids also 4 methyl-1,3,2 dioxaphosphorinane) which contain different functional groups, the remains of heterocyclic amines and alkaloids, new derivatives of some analytical reagents were synthesized. The structure of synthesized compounds is approved by the results of IR-, PMR-, mass-spectrum analyze. Researching mass-spectrum decay of synthesized phosphor acid derivatives we defined that differing from O-dihexyl-S-propargyl-benzylthio phosphat, mass spectrum decay of O-dialkyl-S-(piperdynobutin-2-il)thio phosphat is characterized by the appearing [M-H] + ions and during the decay ions with high intensiveness are formed. Fragmentation of M + O-alkyl-O-(aminoalkyl)phenylphosphonate proceeds in various directions and characterized with the great number of phosphor containing ions, the possession of the second phenyl radical in the molecule of diphenylphosphon acid derivatives changes the fragmentation of molecular ion of diphenylphosphon acid derivatives. The process of extraction of noble (Au, Ag, Pt, Pd, Os) metals from hydrochloric-sulphur-nitrogen acid medium was analyzed by radioactive indicator's method. It was noticed that structure, strength, conformation of compounds, the temperature, of acid medium (0,1-10 M) and the nature of acids (HCL, H 2 SO 4 , HNO 3 ) could have strong influence to the effectiveness of metal extraction. During the research of metals extraction from pure solutions we can see the followings: 1) There are such substances, which can be used as effective group reagent towards the Au, Ag and Pd. 2) Derivatives with acetylene extract ions of gold from

Influence of dome phosphor particle concentration on mid-power LED thermal resistance

NARCIS (Netherlands)

Alexeev, A.; Martin, G.; Hildenbrand, V.D.; Bosschaart, K.J.

2016-01-01

The modern white mid-power LEDs usually contain phosphor particles encapsulated in silicone dome material. The particles convert the blue light emitted from the epitaxial layer and play significant role in thermal processes of LED packages. In this paper the influence of the phosphor particles

Alternative magnesium source for phosphorous recovery – a feasibility and economic analysis

DEFF Research Database (Denmark)

Quist-Jensen, Cejna Anna; Jørgensen, Mads Koustrup; Christensen, Morten Lykkegaard

Conventional reservoirs of phosphorous are in high risk of depletion in near future, thus nontraditional and sustainable recovery-practices are essential to ensure its adequate supply in future. Today phosphorous is being recovered from wastewater at industrial scale by addition of MgCl2. However...

doped LiMgPO4 phosphor

Indian Academy of Sciences (India)

attention because of their remarkable luminescence proper- ties and .... Figure 1. (a) X-ray diffraction patterns of LiMgPO4:Tb3+ phosphor and (b) standard data. ICDD file. .... ground signal which affects the signal to noise ratio [17]. MDD was ...

Study on the relationship between uranium and phosphor in deposit No.60

International Nuclear Information System (INIS)

Zhang Wanliang

1997-01-01

The deposit No.60 is a large uranium-phosphor one located at the eastern margin of the volcanic basin No.65, and controlled by the stratigraphic horizon of the middle-lower part of the third member of the Ehuling Formation composed of volcaniclastic and terrigeneous classic rocks. Uranium and phosphor were preliminarily concentrated together during the formation of ore-hosting layer, and then reactivated, transported and reprecipitated together under the action of tectonothermal process, leading to the concentration of uranium in cellophane in the adsorption state. Uranium and phosphor are closely associated with the correlation coefficient of up to 0.8-0.9

Recovering uranium from phosphoric acid

International Nuclear Information System (INIS)

Abodishish, H.A.; Ritchey, R.W.

1982-01-01

Precipitation of Fe 3 HN 4 H 8 (PO 4 ) 6 is prevented in the second cycle extractor, in a two cycle uranium recovery process, by washing ammonia laden organic solvent stream, from the second cycle stripper, with first cycle raffinate iron stream containing phosphoric acid, prior to passing the solvent stream into the second cycle extractor. (author)

Combustion synthesis of CaSc2O4:Ce3+ nano-phosphors in a closed system

International Nuclear Information System (INIS)

Peng Wenfang; Zou Shaoyu; Liu Guanxi; Xiao Quanlan; Zhang Rui; Xie Lijuan; Cao Liwei; Meng Jianxin; Liu Yingliang

2011-01-01

Highlights: → CaSc 2 O 4 :Ce 3+ nano-phosphors can be prepared by a single-step combustion method. → The ignition temperature is the lowest in the combustion synthesis of Ce 3+ /Eu 2+ doped phosphors. → The as-prepared nano-phosphors give a uniform particle size in the range of 15-20 nm and have highly dispersity and fluorescence intensity. → It is a convenient method for preparation of monodispersed oxide nano-phosphors, especially those being sensitive to air at high temperature. - Abstract: The CaSc 2 O 4 :Ce 3+ nano-phosphors were successfully prepared by a single-step combustion method at an ignition temperature as low as 200 deg. C in a closed autoclave using glycine as a fuel and PEG4000 as a dispersant. The samples were characterized by X-ray diffraction (XRD), photoluminescence (PL) spectroscopy, scanning electron microscopy (SEM) and transmission electron microscope (TEM). The results revealed that CaSc 2 O 4 :Ce 3+ nano-phosphors can be conveniently prepared at an ignition temperature as low as 200 deg. C, which was much lower than that in the ordinary combustion methods. The optimized ignition temperature was 220 deg. C. The CaSc 2 O 4 :Ce 3+ nano-phosphors give a uniform particle size in the range of 15-20 nm. The low ignition temperature and the addition of PEG4000 dispersant play important roles in the formation of small sized nanoparticles. The as-prepared nano-phosphors were incompact aggregates, but highly dispersed nano-phosphors can be obtained after further ultrasonic treatment. The CaSc 2 O 4 :Ce 3+ nano-phosphors give satisfactory luminescence characteristic benefiting from the closed circumstance, in which cerium atoms can be isolated from the oxidizing atmosphere and non-fluorescent Ce 4+ ions can be ruled out. The present highly dispersed CaSc 2 O 4 :Ce 3+ nano-phosphors with efficient fluorescence are promising in the field of biological labeling, and the present low temperature combustion method is facile and convenient and can

TL characterization of Ag co-doped SrSO{sub 4}:Eu phosphor for gamma dosimetry applications

Energy Technology Data Exchange (ETDEWEB)

Jayasudha, S., E-mail: jsnair.india@gmail.com [Mahatma Gandhi College, Pattom Palace P.O., Thiruvananthapuram 695004 (India); Madhukumar, K.; Nair, C.M.K.; Nair, Resmi G.; Anandakumar, V.M. [Mahatma Gandhi College, Pattom Palace P.O., Thiruvananthapuram 695004 (India); Elias, T.S. [State Institute of Cancer Research, Medical College P.O., Thiruvananthapuram 695011 (India); Rajesh, S. [Campus Universitario de Santiago, Aveiro (Portugal)

2017-04-15

High temperature thermoluminescence (TL) emissions and improvement in fading due to the co-doping ofr Ag in the SrSO{sub 4}:Eu phosphor synthesized through chemical precipitation technique when subjected to γ-excitation is discussed. The dopant concentrations were tuned for optimum TL sensitivity. Preliminary crystallographic and structural studies of the phosphors were done using PXRD, SEM, and TEM. The phosphor has a single phase orthorhombic lattice structure and the crystallites are found to be nanostructured. The presence of dopants in the host matrix is established through EDS and ICP-AES studies. The TL glow curve shows a single intense emission at 314 ├ó┬ü┬░C under γ- exposure of dose 1 Gy, which is given from a {sup 60}Co build-up. The dosimetric properties such as sensitivity, dose dependence, fading and reusability of SrSO{sub 4}:Eu,Ag phosphor were also studied. It is observed that co-doping with Ag improves the fading rate of the SrSO{sub 4}:Eu phosphor by about 5%. Even though the luminescence intensity is found to be less than that of SrSO{sub 4}:Eu phosphor, the Ag co-doped phosphor becomes significant owing to its improved fading rate and high temperature afterglow. The gamma sensitivity of the SrSO{sub 4}:Eu,Ag(0.5,0.5 mol%) phosphor is compared to that of the standard CaSO{sub 4}:Dy TLD phosphor. The TL kinetic parameters were calculated using IR, Chen's peak shape method and verified by the theoretical fit using GCD functions. - Highlights: • A High temperature TL emission is observed for the SrSO{sub 4}:Eu,Ag phosphor. • TL intensity is 10 times higher than that of standard CaSO{sub 4}:Dy. • Fading rate of SrSO{sub 4}:Eu phosphor is improved by 5% with Ag co-doping. • Linear dose response in the range 10mGy-10Gy. • t .

Stacking dependence of carrier transport properties in multilayered black phosphorous

Science.gov (United States)

Sengupta, A.; Audiffred, M.; Heine, T.; Niehaus, T. A.

2016-02-01

We present the effect of different stacking orders on carrier transport properties of multi-layer black phosphorous. We consider three different stacking orders AAA, ABA and ACA, with increasing number of layers (from 2 to 6 layers). We employ a hierarchical approach in density functional theory (DFT), with structural simulations performed with generalized gradient approximation (GGA) and the bandstructure, carrier effective masses and optical properties evaluated with the meta-generalized gradient approximation (MGGA). The carrier transmission in the various black phosphorous sheets was carried out with the non-equilibrium green’s function (NEGF) approach. The results show that ACA stacking has the highest electron and hole transmission probabilities. The results show tunability for a wide range of band-gaps, carrier effective masses and transmission with a great promise for lattice engineering (stacking order and layers) in black phosphorous.

Characterization of novel powder and thin film RGB phosphors for field emissions display application

International Nuclear Information System (INIS)

Chakhovskoi, A.G.; Hunt, C.E.

1996-01-01

The spectral response, brightness and outgassing characteristics of new, low-voltage phosphors for application in field-emission flat-panel displays, are presented. The tested phosphor materials include combustion synthesized powders and thin films prepared by RF-diode or magnetron sputtering, laser ablation and molecular beam epitaxy. These cathodoluminescent materials are tested with e-beam excitation at currents up to 50 μA within the 200-2000V (e.g. open-quotes low-voltageclose quotes) and 3-8 kV (e.g. open-quotes medium voltageclose quotes) ranges. The spectral coordinates are compared to commercial low-voltage P22 phosphors. Phosphor outgassing, as a function of time is measured with a residual gas analyzer at fixed 50 μA beam current in the low-voltage range. We find that levels of outgassing stabilize to low values after the first few hours of excitation. The desorption rates measured for powder phosphor layers with different thickness are compared to desorption from thin films

Preliminary study on preparation of BCNO phosphor particles using citric acid as carbon source

Energy Technology Data Exchange (ETDEWEB)

Nuryadin, Bebeh W.; Pratiwi, Tripuspita; Faryuni, Irfana D.; Iskandar, Ferry, E-mail: ferry@fi.itb.ac.id; Abdullah, Mikrajuddin; Khairurrijal [Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Ganesha 10 Bandung, Indonesia 40132 (Indonesia); Ogi, Takashi; Okuyama, Kikuo [Department of Chemical Engineering, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi Hiroshima, Japan 739-8527 (Japan)

2015-04-16

A citric acid was used as a carbon source in the preparation of boron carbon oxy-nitride (BCNO) phosphor particles by a facile process. The preparation process was conducted at relatively low temperature 750 °C and at ambient pressure. The prepared BCNO phosphors showed a high photoluminescence (PL) performance at peak emission wavelength of 470 nm under excitation by a UV light 365 nm. The effects of carbon/boron and nitrogen/boron molar ratios on the PL properties were also investigated. The result showed that the emission spectra with a wavelength peak ranging from 444 nm to 496 nm can be obtained by varying carbon/boron ratios from 0.1 to 0.9. In addition, the observations showed that the BCNO phosphor material has two excitation peaks located at the 365 nm (UV) and 420 nm (blue). Based on these observations, we believe that the citric acid derived BCNO phosphor particles can be a promising inexpensive material for phosphor conversion-based white LED.

Combustion synthesis of red emitting borate host PDP phosphor YCaBO4: Eu3+

International Nuclear Information System (INIS)

Ingle, J.T.; Hargunani, S.P.; Sonekar, R.P.; Nagpure, P.A.; Omanwar, S.K.; Moharil, S.V.

2012-01-01

The red emitting borate host phosphor YCaBO 4 : Eu 3+ has been prepared by a novel solution combustion technique. The synthesis is based on the exothermic reaction between the fuel (Urea) and Oxidizer (Ammonium nitrate). The photoluminescence properties of the powder samples of YCaBO 4 : Eu 3+ has been investigated under UV and VUV excitation. The phosphor shows strong absorption in UV and VUV region and exhibits intense red emission upon excited by 254 nm UV and 173 nm VUV radiation. Under UV 254 nm excitation, YCaBO 4 : Eu 3+ exhibits intense red emission around 610 nm. Under VUV excitation of 173 nm, the phosphor emits intense red emission around 610 nm and few weak emissions. These weak emissions could be suppressed by annealing the sample repeatedly at proper temperature and the borate phosphor YCaBO 4 : Eu 3+ could be a good red emitting phosphor for PDP display and mercury free lamps. (author)

Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy.

Science.gov (United States)

Shi, Hao-Jun; Jin, Chen; Fu, De-Liang

2017-01-14

To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival. Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected before and after surgery, and during the follow-up were evaluated. The associations of glycemic control and nutritional status with complications, tumor recurrence and long-term survival were determined. Risk factors for postoperative glycemic control and nutritional status were identified. High early postoperative fasting blood glucose (FBG) levels (OR = 4.074, 95%CI: 1.188-13.965, P = 0.025) and low early postoperative prealbumin levels (OR = 3.816, 95%CI: 1.110-13.122, P = 0.034) were significantly associated with complications after TP. Postoperative HbA1c levels over 7% (HR = 2.655, 95%CI: 1.299-5.425, P = 0.007) were identified as one of the independent risk factors for tumor recurrence. Patients with postoperative HbA1c levels over 7% had much poorer overall survival than those with HbA1c levels less than 7% (9.3 mo vs 27.6 mo, HR = 3.212, 95%CI: 1.147-8.999, P = 0.026). Patients with long-term diabetes mellitus (HR = 15.019, 95%CI: 1.278-176.211, P = 0.031) and alcohol history (B = 1.985, SE = 0.860, P = 0.025) tended to have poor glycemic control and lower body mass index levels after TP, respectively. At least 3 mo are required after TP to adapt to diabetes and recover nutritional status. Glycemic control appears to have more influence over nutritional status on long-term outcomes after TP. Improvement in glycemic control and nutritional status after TP is important to prevent early complications and tumor recurrence, and improve survival.

Cadmium elemination from phosphoric acid by ionic flotation

International Nuclear Information System (INIS)

Brikci-Nigassa, Mounir; Hamouche, Hafida

1995-11-01

The ion flotation process for the recovery of cadmium from wet phosphoric acid (30%P2O5) has been studied. This technique combines a chemical recation between the collector and the cadmium to form a precipitate (sublate) which is carried to the surface of the solution by air bubbles. the resulting foam containing the cadmium may then separated from solution. The influence of parameters such as collector and cadmium concentration as well as iron content have been investigated for the case a synthetic acid (30% P2O5). The result have been applied to the industrial phosphoric acid produced from Djebel Onk's phosphates (Algeria)

The chemistry of artificial lighting devices lamps, phosphors and cathode ray tubes

CERN Document Server

Ropp, Richard C

2013-01-01

Both the early use of artificial lighting and current manufacturing methods concerning incandescent and fluorescent lamps are covered in this book. The protocols for manufacture of fluorescent lamp phosphors and those used in cathode ray tubes are also treated in some detail. This text surveys the amazing, vast array of artificial lighting devices known to date in terms of how they arose and are, or have been used by mankind. A complete description of the formulations and methodology for manufacturing all known phosphors is given. The book will serve as a repository of such phosphor manufacturing methods, including that of cathode ray tube phosphors. Methods of manufacture of lamp parts are also presented, including that of tungsten wire. The original approaches used are described as well as improvements in technology. These will serve as comparative methods for present day manufacture of these components. A history of the lamp industry is presented. Several methods are given which may serve as a source for f...

Synthesis and cathodoluminescent properties of Y2SiO5:Tb3+ phosphors prepared from uniform precursor

International Nuclear Information System (INIS)

Fan Deyong; Yang Sen; Wang Jieqiong; Zheng Aqun; Song Xiaoping; Yu Demei

2012-01-01

The luminescent properties of phosphors are sensitive to the size of phosphor particles. The commercial Y 2 SiO 5 :Tb 3+ phosphors usually show relatively larger particle size (5–10 μm) due to the irregular morphology of rare earth oxide precursor and thus degrade the luminescent properties. In this paper, we report the Y 2 SiO 5 :Tb 3+ phosphors synthesized from the uniform Tb-doped Y 2 O 3 precursor by a homogeneous precipitation method. Compared with the commercial phosphors, the obtained Y 2 SiO 5 :Tb 3+ phosphors manifest the uniform morphology with much smaller particles distributing from 0.8 μm to 1.9 μm. Consequently, the cathodoluminescent intensity under low excitation voltage (1–5 kV) was increased, demonstrating a strong green emission with a dominant wavelength of 545 nm. Our results indicate an effective way to develop the high-quality phosphors for field emission display. - Highlights: ► The Y 2 SiO 5 :Tb 3+ phosphors are synthesized by a homogeneous precipitation method. ► They manifest the uniform morphology with much smaller particles than commercial one. ► The corresponding cathodoluminescent intensity of green emission is greatly enhanced. ► Our results indicate an effective way to develop the high-quality phosphors for FED.

Study of the onset of deformation and shape coexistence in $^{46}$Ar via the inverse kinematics ($t,p$) reaction

CERN Multimedia

Reiter, P; Blazhev, A A; Nardelli, S; Stora, T; Tengborn, E A; Kruecken, R; Voulot, D; Korten, W; Srebrny, J; Clement, E; Lo bianco, G; Sorlin, O H; Habs, D; Fraile prieto, L M; Chapman, R; Nilsson, T; Diriken, J V J; Jenkins, D G; Wady, P T; Kroell, T; Patronis, N; Angus, L J; Iwanicki, J S

We plan to study states in $^{46}$ Ar via the (t,p) two-neutron transfer reaction in inverse kinematics in order to identify and characterize excited states and to gain insights into the onset of deformation and the possible occurrence of shape-coexistence in this region where the N = 28 shell closure may be weakening. The experiment will be performed using accelerated beams from REX-ISOLDE and the T-REX particle detector set-up inside MINIBALL. We request a total of 30 shifts + 3 shifts for beam commissioning.

Photoluminescent and Thermoluminescent Studies of Dy3+ and Eu3+ Doped Y2O3 Phosphors.

Science.gov (United States)

Verma, Tarkeshwari; Agrawal, Sadhana

2018-01-01

Eu 3+ doped and Dy 3+ codoped yttrium oxide (Y 2 O 3 ) phosphors have been prepared using solid-state reaction technique (SSR). The prepared phosphors were characterized by X-ray diffractometer (XRD), energy dispersive X-ray (EDX) spectroscopy, scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR) techniques. Photoluminescence (PL) and Thermoluminescence (TL) properties were studied in detail. PL emission spectra were recorded for prepared phosphors under excitation wavelength 254 nm, which show a high intense peak at 613 nm for Y 2 O 3 :Dy 3+ , Eu 3+ (1:1.5 mol %) phosphor. The correlated color temperature (CCT) and CIE analysis have been performed for the synthesized phosphors. TL glow curves were recorded for Eu 3+ doped and Dy 3+ codoped phosphors to study the heating rate effect and dose response. The kinetic parameters were calculated using peak shape method for UV and γ exposures through computerized glow curve deconvolution (CGCD) technique. The phosphors show second order kinetics and activation energies varying from 5.823 × 10 - 1 to 18.608 × 10 - 1  eV.

Geochemical Characteristics of TP3 Mine Wastes at the Elizabeth Copper Mine Superfund Site, Orange County, Vermont

Science.gov (United States)

Hammarstrom, Jane M.; Piatak, Nadine M.; Seal, Robert R.; Briggs, Paul H.; Meier, Allen L.; Muzik, Timothy L.

2003-01-01

Remediation of the Elizabeth mine Superfund site in the Vermont copper belt poses challenges for balancing environmental restoration goals with issues of historic preservation while adopting cost-effective strategies for site cleanup and long-term maintenance. The waste-rock pile known as TP3, at the headwaters of Copperas Brook, is especially noteworthy in this regard because it is the worst source of surface- and ground-water contamination identified to date, while also being the area of greatest historical significance. The U.S. Geological Survey (USGS) conducted a study of the historic mine-waste piles known as TP3 at the Elizabeth mine Superfund site near South Strafford, Orange County, VT. TP3 is a 12.3-acre (49,780 m2) subarea of the Elizabeth mine site. It is a focus area for historic preservation because it encompasses an early 19th century copperas works as well as waste from late 19th- and 20th century copper mining (Kierstead, 2001). Surface runoff and seeps from TP3 form the headwaters of Copperas Brook. The stream flows down a valley onto flotation tailings from 20th century copper mining operations and enters the West Branch of the Ompompanoosuc River approximately 1 kilometer downstream from the mine site. Shallow drinking water wells down gradient from TP3 exceed drinking water standards for copper and cadmium (Hathaway and others, 2001). The Elizabeth mine was listed as a Superfund site in 2001, mainly because of impacts of acid-mine drainage on the Ompompanoosuc River.

New NaSrPO4:Sm phosphor as orange-red emitting material

Indian Academy of Sciences (India)

Because NaSr1−xPO4:xSm3+ phosphor features a high colour-rendering index and chemical stability, it is potentially ... use blue LED chips (GaN or InGaN) with a yellow phosphor ... excitation by doping Sm3+ rare earth ions into a suitable.

[Cytogenetical comparison of restorers TP-4 and D minghui63 and maintainer D46B of autotetraploid rice].

Science.gov (United States)

Long, Wen-Bo; Luan, Li; Wang, Xing; Liu, Yu-Hua; Tu, Sheng-Bin; Kong, Fan-Lun; He, Tao

2007-04-01

Cytogenetical comparison was made between high seed set restorers TP-4 and D minghui63 and eminent maintainer line D46B of autotetraploid rice. The meiosis observation demonstrated the genomes of our autotetraploid materials were all 2n = 48, the same as those in mitosis observation. Low percentages of univalent and trivalent in metaphase I (MI) of restorers TP-4 and D minghui63 and in metaphase I (MI) of maintainer line D46B of autotetraploid rice were observed. And the percentages of chromosome pairing were all over 99%, showing eminent cytological character. The frequency of TP-4 and D minghui63 in metaphase I (MI) was 2.00/PMC and 2.26/PMC, respectively. However the frequency of D46B was 6.00/PMC, significantly higher than those of TP-4 and D minghui63. It indicated that the maintainer D46B has better chromosome pairing capability in metaphase I (MI). While, the frequency of lagging chromosomes of the maintainer D46B in anaphase I (AI) was 10.62%, significantly lower than that of TP-4 (19.44%) or D minghui63 (23.14%), and it was close to the level of diploid control (7.30%). In telophase I (TI), maintainer D46B exhibited a lower frequency of microkernel, and in telophase II (TII) the frequency of normal quartered microspore of maintainer D46B was not only higher than that of TP-4 or D minghui63 but also than that of diploid control. The percentage of the cell observed chromosome lagging in A1 and the percentage of abnormal cell in TI showed a greatly significant positive correlation. That may demonstrate chromo some separation in anaphase I (AI) and microkernel formation in telophase I (TI) are controlled by the same dominant single gene or the major gene of QTL.

Flotation of uranium values using di (2-ethyl hexyl) phosphoric acid

International Nuclear Information System (INIS)

Singh, Ajoy Kumar; Padmanabhan, N.P.H.; Sridhar, U.; Krishna Rao, N.

1998-01-01

The use of solvent extractants for mineral flotation, especially for difficult-to-float minerals, is gaining importance as they are highly selective to specific metal ions and form strong and stable complexes mostly by chelation. Studies carried out with di(2 ethyl hexyl) phosphoric acid (D2EHPA) (an organic solvent used in the extraction of uranium from phosphoric acid) as collector for flotation of uranium minerals from ore samples of Domiasiat, Meghalaya and Jaduguda, Bihar have yielded encouraging results. Although flotation of uranium minerals using other solvent extractants like tributyl phosphoric acid (TBP) has been studied, the uraninite-D2EHPA system has not been tested so far. This technical note puts on record the findings of the preliminary studies carried out. (author)

Deletion/duplication mutation screening of TP53 gene in patients with transitional cell carcinoma of urinary bladder using multiplex ligation-dependent probe amplification.

Science.gov (United States)

Bazrafshani, Mohammad Reza R; Nowshadi, Pouriaali A; Shirian, Sadegh; Daneshbod, Yahya; Nabipour, Fatemeh; Mokhtari, Maral; Hosseini, Fatemehsadat; Dehghan, Somayeh; Saeedzadeh, Abolfazl; Mosayebi, Ziba

2016-02-01

Bladder cancer is a molecular disease driven by the accumulation of genetic, epigenetic, and environmental factors. The aim of this study was to detect the deletions/duplication mutations in TP53 gene exons using multiplex ligation-dependent probe amplification (MLPA) method in the patients with transitional cell carcinoma (TCC). The achieved formalin-fixed paraffin-embedded tissues from 60 patients with TCC of bladder were screened for exonal deletions or duplications of every 12 TP53 gene exons using MLPA. The pathological sections were examined by three pathologists and categorized according to the WHO scoring guideline as 18 (30%) grade I, 22 (37%) grade II, 13 (22%) grade III, and 7 (11%) grade IV cases of TCC. None mutation changes of TP53 gene were detected in 24 (40%) of the patients. Furthermore, mutation changes including, 15 (25%) deletion, 17 (28%) duplication, and 4 (7%) both deletion and duplication cases were observed among 60 samples. From 12 exons of TP53 gene, exon 1 was more subjected to exonal deletion. Deletion of exon 1 of TP53 gene has occurred in 11 (35.4%) patients with TCC. In general, most mutations of TP53, either deletion or duplication, were found in exon 1, which was statistically significant. In addition, no relation between the TCC tumor grade and any type of mutation were observed in this research. MLPA is a simple and efficient method to analyze genomic deletions and duplications of all 12 exons of TP53 gene. The finding of this report that most of the mutations of TP53 occur in exon 1 is in contrast to that of the other reports suggesting that exons 5-8 are the most (frequently) mutated exons of TP53 gene. The mutations of exon 1 of TP53 gene may play an important role in the tumorogenesis of TCC. © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

On the corrosion behaviour of phosphoric irons in simulated concrete pore solution

International Nuclear Information System (INIS)

Sahoo, Gadadhar; Balasubramaniam, R.

2008-01-01

The corrosion behaviour of three phosphoric irons P 1 (Fe-0.11P-0.028C), P 2 (Fe-0.32P-0.026C) and P 3 (Fe-0.49P-0.022C) has been studied in simulated concrete pore solution (saturated Ca(OH) 2 solution) containing different chloride concentration. This has been compared with that of two commercial concrete reinforcement steels, a low carbon steel TN (Fe-0.148C-0.542Mn-0.128Si) and a microalloyed corrosion resistant steel CS (Fe-0.151C-0.088P-0.197Si-0.149Cr-0.417Cu). The beneficial aspect of phosphoric irons was revealed from potentiodynamic polarization experiments. The pitting potentials and pitting nucleation resistances for phosphoric irons and CS were higher than that for TN. Electrochemical impedance spectroscopy (EIS) studies revealed thickening and growth of passive film as a function of time in case of phosphoric irons and CS in saturated Ca(OH) 2 pore solutions without chloride and in the same solution with 0.05% Cl - and 0.1% Cl - . In case of TN, breakdown of passive film resulted in active corrosion in simulated pore solution containing 0.1% Cl - . Linear polarization resistance measurements complemented EIS results. Visual observations indicated that phosphoric iron P 3 was immune to corrosion even after 125 days of immersion in saturated Ca(OH) 2 solution containing 5% NaCl. The good corrosion resistance of phosphoric irons in simulated concrete pore solution containing chloride ions has been related to the formation of phosphate, based on ultraviolet spectrophotometric analysis and Pourbaix diagram of phosphorus-water system

Combustion synthesis and photoluminescence in novel red emitting yttrium gadolinium pyrosilicate nanocrystalline phosphor

Energy Technology Data Exchange (ETDEWEB)

Hedaoo, V.P., E-mail: vraikwar@rediffmail.com [Department of Physics, R. J. College, Ghatkopar, Mumbai, MS 400086 (India); Bhatkar, V.B. [Department of Physics, Shri Shivaji Science College, Amravati, MS 444602 (India); Omanwar, S.K. [Department of Physics, SGB Amravati University, Amravati, MS 444602 (India)

2016-07-05

Yttrium Gadolinium Pyrosilicate Y{sub 2-x}Gd{sub x}Si{sub 2}O{sub 7}:Eu{sup 3+} (x = 0.05, 0.10, 0.15) phosphor powder was prepared by facile and time efficient modified combustion method for the first time. The phosphor was characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), photoluminescence excitation (PLE) and emission (PL) spectroscopy and color chromaticity coordinates. XRD revealed the monoclinic crystal structure with space group P1¯. The crystallite size was calculated by Williamson-Hall (W–H) analysis. Nanoplates-like morphology was observed in FESEM analysis with size in the range 50–80 nm. TEM images confirmed the particle size and shape. Upon excitation by 254 nm UV light, the phosphor showed the characteristic red emission peaks at 589 nm and 613 nm corresponding to {sup 5}D{sub 0} → {sup 7}F{sub 1} and {sup 5}D{sub 0} → {sup 7}F{sub 2} transitions respectively. It was observed that the nanocrystalline phosphor Y{sub 2-x}Gd{sub x}Si{sub 2}O{sub 7}:Eu{sup 3+}can be tuned to emit orange to red color by adjusting the ratio Y/Gd. This phosphor thus can be a potential candidate as orange to red color emitting tunable nanocrystalline phosphor for optical devices. - Highlights: • A novel Yttrium Gadolinium Pyrosilicate doped with Eu{sup 3+} is reported. • Facile and time efficient modified combustion method is used. • The nanocrystalline structure was shown by X-ray diffraction, W–H analysis. • FESEM and TEM images confirmed the nanocrystalline structure. • The reported phosphor can be tuned from orange to red by varying Y/Gd ratio.

T/P23, 24, 911 and 92: New grades for advanced coal-fired power plants-Properties and experience

International Nuclear Information System (INIS)

Vaillant, J.C.; Vandenberghe, B.; Hahn, B.; Heuser, H.; Jochum, C.

2008-01-01

After the development of the well-known T/P91 grade in the early 1980s and the long industrial experiences since the early 1990s, it has been necessary to develop new steels to answer the demand of the powergen industry. New (ultra) super critical boilers require materials with advanced creep properties to reach severe steam parameters. For the 2.25% Cr family, grades 23 and 24 are now available to be used instead of the previous grade 22 with many technical and economical advantages. For the 9% Cr steels, new grades such as T/P911 and T/P92 have been developed with higher creep properties than T/P91. Thanks to its large industrial experience in these new grades, Vallourec and Mannesmann Tubes and Boehler Thyssen Schweisstechnik have now worldwide references of use with these new steel grades. In this paper, information on properties, behaviour and workability will be presented with a focus on ·elevated temperature properties and allowable stresses, ·oxidation and maximum service temperature and ·weldability procedures and recommendations

Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells

International Nuclear Information System (INIS)

Kuo, Kung-Kai; Chen, Yi-Ling; Chen, Lih-Ren; Li, Chien-Feng; Lan, Yu-Hsuan; Chang, Fang-Rong; Wu, Yang-Chang; Shiue, Yow-Ling

2011-01-01

The objective was to investigate the upstream apoptotic mechanisms that were triggered by a styrylpyrone derivative, goniothalamin (GTN), in tumor protein p53 (TP53)-positive and -negative hepatocellular carcinoma (HCC)-derived cells. Effects of GTN were evaluated by the flow cytometry, alkaline comet assay, immunocytochemistry, small-hairpin RNA interference, mitochondria/cytosol fractionation, quantitative reverse transcription-polymerase chain reaction, immunoblotting analysis and caspase 3 activity assays in two HCC-derived cell lines. Results indicated that GTN triggered phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1, also known as NOXA)-mediated apoptosis via TP53-dependent and -independent pathways. In TP53-positive SK-Hep1 cells, GTN furthermore induced TP53 transcription-dependent and -independent apoptosis. After GTN treatment, accumulation of reactive oxygen species, formation of DNA double-strand breaks, transactivation of TP53 and/or PMAIP1 gene, translocation of TP53 and/or PMAIP1 proteins to mitochondria, release of cytochrome c from mitochondria, cleavage of caspases and induction of apoptosis in both cell lines were sustained. GTN might represent a novel class of anticancer drug that induces apoptosis in HCC-derived cells through PMAIP1 transactivation regardless of the status of TP53 gene. - Highlights: → Goniothalamin (GTN) induced apoptosis in hepatocellular carcinomas-derived cells. → The apoptosis induced by GTN is PMAIP1-dependent, regardless of TP53 status. → The apoptosis induced by GTN might be TP53 transcription-dependent or -independent. → GTN-induced apoptosis is mitochondria- and caspases-mediated.

Mechano-luminescence studies of nano ZnMgAl10O17:Eu phosphor under UV irradiation

Science.gov (United States)

Verma, Akshkumar; Verma, Ashish; Panda, Maheswar

2018-05-01

ZnMgAl10O17:Eu nano phosphors were prepared successfully, using the combustion route by employing urea as a fuel. The structural, and Morphological, properties were measured using x-ray diffraction (XRD) Scanning electron microscopy (SEM) transition electron microscopy. The BET surface area of sample were found to be of ˜13.92 m2/g. The ML (Mechano-luminescence) were measured to the home made instrument. The phosphor showed more strong and high ML intensity to the without UV irradiated material. Therefore ZnMgAl10O17:Eu2+ phosphor may use as a damage sensor and dosimetry material. The ML emission spectra of the Zn0.99MgAl10O17:Eu0.01 phosphor showed the characteristic Eu2+ emission peaks ˜453nm (blue) originating from the transitions 4f65d1→4f7, Therefore ZnMgAl10O17:Eu2+ phosphor may use as a blue phosphor material.

Spectral downshifting in MBO{sub 3}:Nd{sup 3+} (M=Y, La) phosphor

Energy Technology Data Exchange (ETDEWEB)

Omanwar, S.K.; Sawala, N.S. [Sant Gadge Baba Amravati University, Department of Physics, Amravati, MH (India)

2017-11-15

The spectral downshifting (DS) from ultra-violet (UV)/visible (VIS) light to near infra-red (NIR) radiation in Nd{sup 3+} doped YBO{sub 3} and LaBO{sub 3} phosphors is reported. The prepared materials were characterized by X-ray powder diffraction (XRD) and photoluminescence (PL) properties along with time-decay curves were studied which confirmed the spectral DS from VIS to NIR radiation. This can be employed to overcome the spectral mismatch of crystalline silicon (c-Si) solar cell with solar spectrum. The prepared Nd{sup 3+} doped as prepared phosphors provide NIR emission (1052 nm) at excitation of 586 nm where response of c-Si solar cell was optimum. Thus spectral modification by mentioned phosphor can be utilized to improve solar cells performance. Hence these phosphors have potential application for photovoltaic (PV) technology. (orig.)

Recovery of uranium in the production of concentrated phosphoric acid by a hemihydrate process

International Nuclear Information System (INIS)

Nakajima, S.; Miyamoto, M.

1983-01-01

Nissan Chemical Industries as manufacturers of phosphoric acid have studied the recovery of uranium, based on a concentrated phosphoric acid production process. The process consists of two stages, a hemihydrate stage with a formation of hemihydrate and a filtration section, followed by a dihydrate stage with hydration and a filtration section. In the hemihydrate stage, phosphate is treated with a mixture of phosphoric acid and sulphuric acid to produce phosphoric acid and hydrous calcium sulphate; the product is recovered in the filtration section and its concentration is 40-50% P 2 O 3 . In the dihydrate stage, the hemihydrate is transformed by re-dissolution and hydration, producing hydrous calcium sulphate, i.e. gypsum. This process therefore comprises two parts, each with different acid concentrations. As the extraction of uranium is easier in the case of a low concentration of phosphoric acid, the process consists of the recovery of uranium starting from the filtrate of the hydration section. The tests have shown that the yield of recovery of uranium was of the order of 80% disregarding the handling losses and no disadvantageous effect has been found in the combination of the process of uranium extraction with the process of concentrated phosphoric acid production. Compared with the classical process where uranium is recovered from acid with 30% P 2 O 5 , the process of producing high-concentration phosphoric acid such as the Nissan process, in which the uranium recovery is effected from acid with 15% P 2 O 5 from the hydration section, presents many advantages [fr

Thermoluminescent dosimetry of new phosphors of Zn O exposed to beta radiation

International Nuclear Information System (INIS)

Cruz V, C.; Burruel I, S.E.; Grijalva M, H.; Barboza F, M.; Bernal, R.

2004-01-01

In this work, we report the thermoluminescence dosimetry of a new Zn O phosphor obtained by annealing of Zn S powder precipitated when Zn S films were grown by employing a CBD method. The collected Zn S powder was pressed in a die to form pellets which were subjected to different thermal treatments under air atmosphere. X-ray diffraction (XRD) patterns and energy-dispersive X-ray Spectrometry (EDS) analyses confirmed the transformation of Zn S to Zn O. The phosphors thus obtained were exposed to high doses of beta radiation and their thermoluminescent dosimetry show that these new phosphors are materials suitable to be used in high dose thermoluminescence dosimetry. (Author)

Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.

Science.gov (United States)

Mascaro-Cordeiro, Bruna; Oliveira, Indhira Dias; Tesser-Gamba, Francine; Pavon, Lorena Favaro; Saba-Silva, Nasjla; Cavalheiro, Sergio; Dastoli, Patrícia; Toledo, Silvia Regina Caminada

2018-05-22

Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB). In the present study, we investigated VA role, combined to cisplatin (CDDP) in cell viability and gene expression of MB cell lines. Dose-response curve determined IC 50 values for each treatment: (1) VA single, (2) CDDP single, and (3) VA and CDDP combined. Cytotoxicity and flow cytometry evaluated cell viability after exposure to treatments. Quantitative PCR evaluated gene expression levels of AKT, CTNNB1, GLI1, KDM6A, KDM6B, NOTCH2, PTCH1, and TERT, before and after treatment. Besides, we performed next-generation sequencing (NGS) for PTCH1, TERT, and TP53 genes. The most effective treatment to reduce viability was combined for D283MED and ONS-76; and CDDP single for DAOY cells (p AKT genes were overexpressed after treatments with VA. D283MED and ONS-76 cells presented variants in TERT and PTCH1, respectively and DAOY cell line presented a TP53 mutation. MB tumors belonging to SHH molecular subgroup, with TP53 MUT , would be the ones that present high risk in relation to VA use during the treatment, while TP53 WT MBs can benefit from VA therapy, both SHH and groups 3 and 4. Our study shows a new perspective about VA action in medulloblastoma cells, raising the possibility that VA may act in different patterns. According to the genetic background of MB cell, VA can stimulate cell cycle arrest and apoptosis or induce resistance to treatment via signaling pathways activation.

Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxel.

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Ranjan Chrisanthar

Full Text Available BACKGROUND: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP T309G increases MDM2 activity and may reduce wild-type p53 protein activity. Here, we explored the predictive and prognostic value of TP53 and CHEK2 mutation status together with MDM2 SNP309 genotype in stage III breast cancer patients receiving paclitaxel or epirubicin monotherapy. EXPERIMENTAL DESIGN: Each patient was randomly assigned to treatment with epirubicin 90 mg/m(2 (n = 109 or paclitaxel 200 mg/m(2 (n = 114 every 3rd week as monotherapy for 4-6 cycles. Patients obtaining a suboptimal response on first-line treatment requiring further chemotherapy received the opposite regimen. Time from last patient inclusion to follow-up censoring was 69 months. Each patient had snap-frozen tumor tissue specimens collected prior to commencing chemotherapy. PRINCIPAL FINDINGS: While TP53 and CHEK2 mutations predicted resistance to epirubicin, MDM2 status did not. Neither TP53/CHEK2 mutations nor MDM2 status was associated with paclitaxel response. Remarkably, TP53 mutations (p = 0.007 but also MDM2 309TG/GG genotype status (p = 0.012 were associated with a poor disease-specific survival among patients having paclitaxel but not patients having epirubicin first-line. The effect of MDM2 status was observed among individuals harbouring wild-type TP53 (p = 0.039 but not among individuals with TP53 mutated tumors (p>0.5. CONCLUSION: TP53 and CHEK2 mutations were associated with lack of response to epirubicin monotherapy. In contrast, TP53 mutations and MDM2 309G allele status conferred poor disease-specific survival among patients treated with primary paclitaxel but not epirubicin monotherapy.

Combination of carbon dot and polymer dot phosphors for white light-emitting diodes.

Science.gov (United States)

Sun, Chun; Zhang, Yu; Sun, Kai; Reckmeier, Claas; Zhang, Tieqiang; Zhang, XiaoYu; Zhao, Jun; Wu, Changfeng; Yu, William W; Rogach, Andrey L

2015-07-28

We realized white light-emitting diodes with high color rendering index (85-96) and widely variable color temperatures (2805-7786 K) by combining three phosphors based on carbon dots and polymer dots, whose solid-state photoluminescence self-quenching was efficiently suppressed within a polyvinyl pyrrolidone matrix. All three phosphors exhibited dominant absorption in the UV spectral region, which ensured the weak reabsorption and no energy transfer crosstalk. The WLEDs showed excellent color stability against the increasing current because of the similar response of the tricolor phosphors to the UV light variation.

Thermally stimulated properties in ZnSe:Tb and ZnSe:(Mn, Tb) phosphors

Science.gov (United States)

Mishra, A. K.; Mishra, S. K.; Pandey, S. P.; Lakshmi Mishra, Kshama

2018-02-01

Thermoluminescence studies were performed of ZnSe:Tb and ZnSe:(Mn, Tb) phosphors. A method of preparation for ZnSe phosphors doped with Tb and (Mn, Tb) has been discussed. The thermoluminescence (TL) properties of these phosphors have been studied from 100 to 370 K temperature after exciting by UV radiation (365 nm) at three uniform heating rates 0.4, 0.6 and 0.9 K/s. The trapping parameters like trap depth, lifetime of electrons and capture cross-section have also been determined using various methods.

TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

DEFF Research Database (Denmark)

Munch-Petersen, Helga D; Asmar, Fazila; Dimopoulos, Konstantinos

2016-01-01

regimens (high-dose methotrexate/whole brain radiation therapy, 6.0 months, or no therapy, 0.83 months), P hotspot/direct DNA contact mutations. CCT-treated patients with PCNSL harboring a hotspot/direct DNA contact MUT......-TP53 (n = 9) had a significantly worse OS and progression free survival (PFS) compared to patients with non-hotspot/non-direct DNA contact MUT-TP53 or wild-type TP53 (median PFS 4.6 versus 18.2 or 45.7 months), P = 0.041 and P = 0.00076, respectively. Multivariate Cox regression analysis confirmed...... that hotspot/direct DNA contact MUT-TP53 was predictive of poor outcome in CCT-treated PCNSL patients, P = 0.012 and P = 0.008; HR: 1.86 and 1.95, for OS and PFS, respectively. MIR34A, MIR34B/C, and DAPK promoter methylation were detected in 53/93 (57.0 %), 80/84 (95.2 %), and 70/75 (93.3 %) of the PCNSL...

Improvement of Lighting Uniformity and Phosphor Life in Field Emission Lamps Using Carbon Nanocoils

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Kun-Ju Chung

2015-01-01

Full Text Available The lighting performances and phosphor degradation in field emission lamps (FELs with two different kinds of cathode materials—multiwalled carbon nanotubes (MWCNTs and carbon nanocoils (CNCs—were compared. The MWCNTs and CNCs were selectively synthesized on 304 stainless steel wire substrates dip-coated with nanosized Pd catalysts by controlling the growth temperature in thermal chemical vapor deposition, and the film uniformity can be optimized by adjusting the growth time. FELs were successfully fabricated by assembling these cathode filaments with a glass bulb-type anode. The FEL with the CNC cathode showed much higher lighting uniformity and light-spot density and a lower current at the same voltage than that with the MWCNT cathode filament, and its best luminous efficiency was as high as 75 lm/W at 8 kV. We also found that, for P22, the phosphor degradation can be effectively suppressed by replacing MWCNTs with CNCs in the cathode, due to the much larger total bright spot area and hence much lower current density loading on the anode.

Process for recovery of uranium from wet process phosphoric acid

International Nuclear Information System (INIS)

Wiewiorowski, T.K.; Thornsberry, W.L. Jr.

1978-01-01

Process is claimed for the recovery of uranium from wet process phosphoric acid solution in which an organic extractant, containing uranium values and dissolved iron impurities and comprising a dialkylphosphoric acid and a trialkylphosphine oxide dissolved in a water immiscible organic solvent, is contacted with a substantially iron-free dilute aqueous phosphoric acid to remove said iron impurities. The removed impurities are bled from the system by feeding the resulting iron-loaded phosphoric acid to a secondary countercurrent uranium extraction operation from which they leave as part of the uranium-depleted acid raffinate. Also, process for recovering uranium in which the extractant, after it has been stripped of uranium values by aqueous ammonium carbonate, is contacted with a dilute aqueous acid selected from the group consisting of H 2 SO 4 , HCl, HNO 3 and iron-free H 3 PO 4 to improve the extraction efficiency of the organic extractant

Leaching behavior of total organic carbon, nitrogen, and phosphorus from banana peel.

Science.gov (United States)

Jiang, Ruixue; Sun, Shujuan; Xu, Yan; Qiu, Xiudong; Yang, Jili; Li, Xiaochen

2015-01-01

The leaching behavior of organic carbon and nutrient compounds from banana peel (BP) was investigated in batch assays with respect to particle size, contact time, pH value, and temperature. The granularity, contact time, pH, and temperature caused no significant effects on the leaching of total phosphorus (TP) from the BP. The maximum leached total nitrogen (TN) content was found at pH 5.0 and 90 minutes, while no significant effects were caused by the granularity and temperature. The maximum leached total organic carbon (TOC) content was found by using a powder of 40 mesh, 150 minutes and at pH 6.0, while the temperature had no effect on the TOC leaching. The proportions of the TN, TP, and TOC contents leached from the dried BP ranged from 33.6% to 40.9%, 60.4% to 72.7%, and 8.2% to 9.9%, respectively, indicating that BP could be a potential pollution source for surface and ground water if discharged as domestic waste or reutilized without pretreatment.

Feasibility of vermicomposting dewatered sludge from paper mills using Perionyx excavatus

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Puspanjali Sonowal

2013-06-01

Full Text Available India has a large network of pulp and paper mills of varying capacity. On an industrial scale the sludge from paper and pulp mills is disposed of either as landfill or incinerated. Both methods result in the loss of a valuable resource and have obvious environmental and economic disadvantages. The solid waste from pulp and paper mills is a source of organic matter and its proper disposal and management is the responsibility of the industry. As composting/vermicomposting could be used to transform this waste trials were carried out to determine the feasibility of converting dewatered sludge (DS into a value added end product using an earthworm, Perionyx excavatus. The vermicomposting of the waste resulted in an increase in its electrical conductivity (EC, ash content, total nitrogen (TN, total phosphorous (TP and available phosphorous (AP, respectively, and a decrease in total organic carbon (TOC, biochemical oxygen demand (BOD, chemical oxygen demand (COD, oxygen uptake rate (OUR and evolution of carbon dioxide (CO2. Overall, the best treatment was T5 in which there was a 76.1% increase in TP, 58.7% in TN, 74.5% decrease in TOC , and a reduction of 6.7 fold in the production of CO2 and 10.7 fold in BOD, respectively. Our trials demonstrate that vermicomposting using an epigeic earthworm, Perionyx excavatus, is an alternate and environmentally safe way of recycling paper mill sludge if it is mixed with an appropriate amount of cow dung and food processing waste. Overall T5 was the best combination of paper mill sludge and waste for vermicomposting followed by T3, T2, T4 and T1, respectively.

Combined and synergistic effects of climate change and urbanization on water quality in the Wolf Bay watershed, southern Alabama.

Science.gov (United States)

Wang, Ruoyu; Kalin, Latif

2018-02-01

This study investigated potential changes in flow, total suspended solid (TSS) and nutrient (nitrogen and phosphorous) loadings under future climate change, land use/cover (LULC) change and combined change scenarios in the Wolf Bay watershed, southern Alabama, USA. Four Global Circulation Models (GCMs) under three Special Report Emission Scenarios (SRES) of greenhouse gas were used to assess the future climate change (2016-2040). Three projected LULC maps (2030) were employed to reflect different extents of urbanization in future. The individual, combined and synergistic impacts of LULC and climate change on water quantity/quality were analyzed by the Soil and Water Assessment Tool (SWAT). Under the "climate change only" scenario, monthly distribution and projected variation of TSS are expected to follow a pattern similar to streamflow. Nutrients are influenced both by flow and management practices. The variation of Total Nitrogen (TN) and Total Phosphorous (TP) generally follow the flow trend as well. No evident difference in the N:P ratio was projected. Under the "LULC change only" scenario, TN was projected to decrease, mainly due to the shrinkage of croplands. TP will increase in fall and winter. The N:P ratio shows a strong decreasing potential. Under the "combined change" scenario, LULC and climate change effect were considered simultaneously. Results indicate that if future loadings are expected to increase/decrease under any individual scenario, then the combined change will intensify that trend. Conversely, if their effects are in opposite directions, an offsetting effect occurs. Science-based management practices are needed to reduce nutrient loadings to the Bay. Copyright © 2017. Published by Elsevier B.V.

Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Science.gov (United States)

Jen, Kuang-Yu; Song, Ihn Young; Banta, Karl Luke; Wu, Di; Mao, Jian-Hua; Balmain, Allan

2012-01-19

T-cell acute lymphoblastic lymphomas commonly demonstrate activating Notch1 mutations as well as mutations or deletions in Fbxw7. However, because Fbxw7 targets Notch1 for degradation, genetic alterations in these genes are expected to be mutually exclusive events in lymphomagenesis. Previously, by using a radiation-induced Tp53-deficient mouse model for T-cell acute lymphoblastic lymphoma, we reported that loss of heterozygosity at the Fbxw7 locus occurs frequently in a Tp53-dependent manner. In the current study, we show that these thymic lymphomas also commonly exhibit activating Notch1 mutations in the proline-glutamic acid-serine-threonine (PEST) domain. Moreover, concurrent activating Notch1 PEST domain mutations and single-copy deletions at the Fbxw7 locus occur with high frequency in the same individual tumors, indicating that these changes are not mutually exclusive events. We further demonstrate that although Notch1 PEST domain mutations are independent of Tp53 status, they are completely abolished in mice with germline Fbxw7 haploinsufficiency. Therefore, Notch1 PEST domain mutations only occur when Fbxw7 expression levels are intact. These data suggest a temporal sequence of mutational events involving these important cancer-related genes, with Notch1 PEST domain mutations occurring first, followed by Fbxw7 deletion, and eventually by complete loss of Tp53.

Extractants for uranium recovery from wet phosphoric acid

International Nuclear Information System (INIS)

Musikas, C.; Benjelloun, N.; Lours, S.

1982-01-01

Synergistic mixtures containing phosphine oxide plus one of the acidic extractants: dialkyldithiophosphoric acid, dialkylthiophosphoric acid and dialkylphosphoric acid have been compared with respect to U(VI) and Fe(III) extraction from wet phosphoric acid. Distribution curves slope analysis showed that U(VI) extraction mechanisms are totally different. It has been found that U(VI) is extracted as: UO 2 (H 2 PO 4 )(DEHDTP)(TOPO) ; UO 2 (H 2 PO 4 )(DBTP)(POX) 2 and UO 2 (DEHP)(HDEHP) 2 TOPO in dodecane solutions containing di 2 ethylhexyldithiophosphoric acid (HDEHDTP) or dibutylthiophosphoric acid (HDBTP) or di-2-ethylhexylphosphoric acid (HDEHP) plus a phosphine oxide (TOPO or dihexylmethoxyoctylphosphine oxide (POX 11)). The synergistic mixtures containing HDEHDTP gave the highest U(VI) distribution coefficients. Back extraction with oxalic solutions can be achieved only with the synergistic mixtures containing the acidic thiophosphoric donors

Modeling Phosphorous Losses from Seasonal Manure Application Schemes

Science.gov (United States)

Menzies, E.; Walter, M. T.

2015-12-01

Excess nutrient loading, especially nitrogen and phosphorus, to surface waters is a common and significant problem throughout the United States. While pollution remediation efforts are continuously improving, the most effective treatment remains to limit the source. Appropriate timing of fertilizer application to reduce nutrient losses is currently a hotly debated topic in the Northeastern United States; winter spreading of manure is under special scrutiny. We plan to evaluate the loss of phosphorous to surface waters from agricultural systems under varying seasonal fertilization schemes in an effort to determine the impacts of fertilizers applied throughout the year. The Cayuga Lake basin, located in the Finger Lakes region of New York State, is a watershed dominated by agriculture where a wide array of land management strategies can be found. The evaluation will be conducted on the Fall Creek Watershed, a large sub basin in the Cayuga Lake Watershed. The Fall Creek Watershed covers approximately 33,000 ha in central New York State with approximately 50% of this land being used for agriculture. We plan to use the Soil and Water Assessment Tool (SWAT) to model a number of seasonal fertilization regimes such as summer only spreading and year round spreading (including winter applications), as well as others. We will use the model to quantify the phosphorous load to surface waters from these different fertilization schemes and determine the impacts of manure applied at different times throughout the year. More detailed knowledge about how seasonal fertilization schemes impact phosphorous losses will provide more information to stakeholders concerning the impacts of agriculture on surface water quality. Our results will help farmers and extensionists make more informed decisions about appropriate timing of manure application for reduced phosphorous losses and surface water degradation as well as aid law makers in improving policy surrounding manure application.

Planar measurements of spray-induced wall cooling using phosphor thermometry

Science.gov (United States)

Dragomirov, Plamen; Mendieta, Aldo; Abram, Christopher; Fond, Benoît; Beyrau, Frank

2018-03-01

The wall cooling induced by spray impingement is investigated using phosphor thermometry. Thin coatings of zinc oxide (ZnO) phosphor were applied with a transparent chemical binder onto a steel surface. Instantaneous spatially resolved temperatures were determined using the spectral intensity ratio method directly after the injection of UV-grade hexane onto the surface using a commercial gasoline injector. The investigations showed that 2D temperature measurements with high spatial and shot-to-shot precision of, respectively, 0.5 and 0.6 K can be achieved, allowing the accurate resolution of the cooling induced by the spray. The presence of a liquid film over the phosphor coating during measurements showed no noticeable influence on the measured temperatures. However, in some cases a change in the intensity ratio at the spray impingement area, in the form of a permanent "stain", could be observed after multiple injections. The formation of this stain was less likely with increasing annealing time of the coating as well as lower plate operating temperatures during the injection experiments. Finally, the experimental results indicate a noticeable influence of the thickness of the phosphor coating on the measured spray-induced wall cooling history. Hence, for quantitative analysis, a compromise between coating thickness and measurement accuracy needs to be considered for similar applications where the heat transfer rates are very high.

Natural Radiation in byproducts of the production of phosphoric acid

International Nuclear Information System (INIS)

Silveira, Marcilei A. Guazzelli da; Cardoso, L.L.; Medina, N.H.

2014-01-01

Natural radiation is the largest source of radiation exposure to which man is subject. It is formed basically by cosmic radiation and the radionuclides present in the Earth crust, as 40 K and the elements of the decay series of 232 Th and 238 U. Phosphate ores, which constitutes the raw material for the production of phosphoric acid, have a high rate of natural radiation from the decay series of 232 Th and 238 U. Phosphogypsum, which is naturally radioactivity, is a by-product of the production of phosphoric acid by the wet method. For each ton of phosphoric acid it is produced about 4.5 tons of phosphogypsum. This work presents the analysis of samples collected in all stages of the manufacturing process of phosphoric acid, which generates the phosphogypsum. Gamma-ray spectrometry was used to measure the concentration of the elements of the decay series of 232 Th and 238 U. All analyzed samples showed a high concentration of radionuclides, promoting the need for further steps in the process in order to reduce the presence of such radionuclides in the phosphogypsum. The results indicate the radionuclide 238 U has higher contribution in some samples of the intermediate stages of the process. All samples exceeded the international average range of human exposure to terrestrial gamma radiation, which is 0.3 to 1.0 mSv/year. (author)

Extraction studies on rare earths using dinonyl phenyl phosphoric acid

International Nuclear Information System (INIS)

Anitha, M.; Singh, D.K.; Kotekar, M.K.; Vijayalakshmi, R.; Singh, H.

2011-01-01

Rare earths are widely used in phosphor materials, magnetic substances, alloys, catalyst, lasers, superconductors, solid oxide fuel cells and in nuclear applications. The high value of these elements depends on their effective separation into high purity compounds. The separation into individual rare earths is very difficult to achieve, due to the very low separation factors between two adjacent rare earths arising due to similar chemical properties. Taking the advantage of variation in basicity, the separation is generally accomplished by solvent extraction or ion exchange. There are several references on the separation of rare earth in different media employing various types of extractants such as 2-ethylhexyl 2-ethyhexylphosphonic acid (EHEHPA) and di-2-ethyl hexyl phosphoric acid (D2EHPA) which have been widely used for the separation and purification of rare earths. Dinonyl phenyl phosphoric acid (DNPPA) is an organo phosphorus extractant (pKa = 2.54) and is an aromatic analogue of D2EHPA, which extracts metal ion by cation exchange mechanism. DNPPA was explored to recover rare earths from phosphate media such as wet process phosphoric acid and merchant grade acid. However, there is no information available in literature on DNPPA for RE extraction from chloride medium. Therefore, an attempt has been made in the present study to investigate the feasibility of using DNPPA for extraction of La(III), Dy(III) and Y(III) from chloride medium

Kinetic parameters and TL mechanism in cadmium tetra borate phosphor

International Nuclear Information System (INIS)

Annalakshmi, O.; Jose, M.T.; Sridevi, J.; Venkatraman, B.; Amarendra, G.; Mandal, A.B.

2014-01-01

Polycrystalline powder samples of cadmium tetra borate were synthesized by a simple solid state sintering technique and gamma irradiated sample showed a simple Thermoluminescence (TL) glow peak around 460 K. The TL kinetic parameters of gamma irradiated phosphor were determined by initial rise (IR), isothermal decay (ID), peak shape (PS), variable heating rate (VHR) and glow curve de-convolution method. The kinetic parameters such as activation energy (E), frequency factor (s) and order of kinetics (b) were calculated by IR, ID, PS and VHR methods are in the order of ∼1.05 eV, 10 9 –10 12 s −1 and 1.58, respectively. From the results of TL and PL emission studies carried out on the phosphor revealed that the defect centers related to TL is different from that for PL. EPR measurements were carried out to identify the defect centers formed in cadmium tetra borate phosphor on gamma irradiation. Based on EPR studies the mechanism for TL process in cadmium tetra borate is proposed in this paper -- Highlights: • Polycrystalline powder samples of undoped cadmium tetra borate synthesized. • Cadmium tetra borate phosphor exhibits a dosimetric peak at 458 K. • Kinetic parameters of the trap responsible for TL evaluated. • TL mechanism is proposed from TL to EPR correlation studies

Kinetic parameters and TL mechanism in cadmium tetra borate phosphor

Energy Technology Data Exchange (ETDEWEB)

Annalakshmi, O. [Radiological Safety Division, Materials Physics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Jose, M.T., E-mail: mtj@igcar.gov.in [Radiological Safety Division, Materials Physics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Sridevi, J. [Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai 600 020, Tamilnadhu (India); Venkatraman, B. [Radiological Safety Division, Materials Physics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Amarendra, G. [Materials Physics Division, Indira Gandhi Centre for Atomic Research, Kalpakkam-603102 (India); Mandal, A.B. [Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai 600 020, Tamilnadhu (India)

2014-03-15

Polycrystalline powder samples of cadmium tetra borate were synthesized by a simple solid state sintering technique and gamma irradiated sample showed a simple Thermoluminescence (TL) glow peak around 460 K. The TL kinetic parameters of gamma irradiated phosphor were determined by initial rise (IR), isothermal decay (ID), peak shape (PS), variable heating rate (VHR) and glow curve de-convolution method. The kinetic parameters such as activation energy (E), frequency factor (s) and order of kinetics (b) were calculated by IR, ID, PS and VHR methods are in the order of ∼1.05 eV, 10{sup 9}–10{sup 12} s{sup −1} and 1.58, respectively. From the results of TL and PL emission studies carried out on the phosphor revealed that the defect centers related to TL is different from that for PL. EPR measurements were carried out to identify the defect centers formed in cadmium tetra borate phosphor on gamma irradiation. Based on EPR studies the mechanism for TL process in cadmium tetra borate is proposed in this paper -- Highlights: • Polycrystalline powder samples of undoped cadmium tetra borate synthesized. • Cadmium tetra borate phosphor exhibits a dosimetric peak at 458 K. • Kinetic parameters of the trap responsible for TL evaluated. • TL mechanism is proposed from TL to EPR correlation studies.

Quality parameters evaluation for the determination of available phosphorous in soils

International Nuclear Information System (INIS)

Garcia Galvis, John Brynner; Ballesteros, Maria Ines

2006-01-01

There are some colorimetric procedures for determining available phosphorous in soils, and phosphorous is evaluated by means of a blue complex (phosphomolybdic acid); in one of the methods, color appear when ascorbic acid is used as reductor agent, and in the other when stannous chloride is used. Both methods use the same extractive solution bray i i due to its good response for acid soil cultures, like most Colombian soils are. When the two methodologies were compared it was found that the most sensible method and with the best limit of detection and quantification was the one that uses ascorbic acid, antimonious and potassium tartrate. Its variation coefficients and standard deviation were lower, and for this reason it is considered as the most precise method for phosphorous determination

Health assessment of free-living eastern box turtles (Terrapene carolina carolina) in and around the Maryland Zoo in Baltimore 1996-2011.

Science.gov (United States)

Adamovicz, Laura; Bronson, Ellen; Barrett, Kevin; Deem, Sharon L

2015-03-01

Health data for free-living eastern box turtles (Terrapene carolina carolina) at the Maryland Zoo in Baltimore were analyzed. One hundred and eighteen turtles were captured on or near zoo grounds over the course of 15 yr (1996-2011), with recapture of many individuals leading to 208 total evaluations. Of the 118 individuals, 61 were male, 50 were female, and 7 were of undetermined sex. Of the 208 captures, 188 were healthy, and 20 were sick or injured. Complete health evaluations were performed on 30 turtles with physical examination records, complete blood counts (CBCs), and plasma biochemistry profiles. Eight animals were sampled more than once, yielding 40 total samples for complete health evaluations of these 30 individuals. The 40 samples were divided into healthy (N=29) and sick (N=11) groups based on clinical findings on physical examination. Samples from healthy animals were further divided into male (N=17) and female (N= 12) groups. CBC and biochemistry profile parameters were compared between sick and healthy groups and between healthy males and females. Sick turtles had lower albumin, globulin, total protein (TP), calcium, phosphorous, sodium, and potassium than healthy animals. Sick turtles also had higher heterophil to lymphocyte ratios. Healthy female turtles had higher leukocyte count, eosinophil count, total solids, TP, globulin, cholesterol, calcium, and phosphorous than healthy males. Banked plasma from all 40 samples was tested for antibodies to Mycoplasma agassizii and Mycoplasma testudineum via enzyme-linked immunosorbent assay. One sample from a clinically healthy female was antibody positive for M. agassizii; none were positive for M. testudineum. This study provides descriptive health data for eastern box turtles and CBC and biochemistry profile information for T. carolina carolina at and near the Maryland Zoo in Baltimore. It also reports low serologic evidence of exposure to mycoplasmosis.

Polimorfismo do gene tp53 no códon 72 em pacientes com suspeita de LMC Codon 72 polymorphism of the TP53 gene in patients suspected to have CML

Directory of Open Access Journals (Sweden)

Camila S. Hamú

2007-12-01

Full Text Available A leucemia mielóide crônica (LMC é uma doença proliferativa do sistema hematopoiético, caracterizada pela expansão clonal de uma célula-tronco primitiva e pluripotente denominada stem cell. Este tipo de leucemia está associado, em 90% dos casos, à translocação t(9;22(q34;q11. Essa alteração cromossômica estrutural codifica para uma proteína quimérica BCR-ABL, que confere às células leucêmicas uma alta resistência à morte, independente do agente indutor desse processo. A proteína p53 é uma reguladora transcricional induzida por danos no DNA, fato que resulta na parada do ciclo celular com conseqüente ativação de mecanismos de reparo ou mesmo na indução à apoptose. As mutações no gene TP53 são as alterações genéticas mais comuns em tumores malignos humanos. O presente estudo teve como objetivo genotipar e determinar a freqüência alélica do polimorfismo do TP53 no códon 72 (arginina - Arg e prolina - Pro, em pacientes com suspeita de LMC, pela Reação em Cadeia da Polimerase. Desta forma, os resultados indicaram que 73,4% (23/30 dos pacientes apresentaram homozigose para arginina (Arg/Arg e 26,6% (7/30 heterozigose (Arg/Pro. Não foi encontrado nenhum paciente homozigoto para prolina (Pro/Pro. Os resultados obtidos sugerem que o polimorfismo do gene TP53 no códon 72 não é um fator de risco importante para a iniciação, promoção e progressão da LMC.Chronic myeloid leukemia (CML is a proliferative disorder of the hematopoietic system characterized by clonal expansion of a primitive and pluripotent stem cell. In this type of leukemia, up to 90% of all cases is associated to a specific chromosomal translocation, t(9;22(q34;q11. The genomic alteration results in a chimeric protein, BCR-ABL, that confers a high resistance leukemia cells to death, independent of the induction mechanism of this process. Protein p53 is a transcriptional factor expressed after DNA damage which ceases cell cycle progression and

Key Players in the Genetic Switch of Bacteriophage TP901-1

DEFF Research Database (Denmark)

Alsing, Anne; Pedersen, Margit; Sneppen, Kim

2011-01-01

the bistable genetic switch of bacteriophage TP901-1 through experiments and statistical mechanical modeling. We examine the activity of the lysogenic promoter Pr at different concentrations of the phage repressor, CI, and compare the effect of CI on Pr in the presence or absence of the phage-encoded MOR...

Determination of surface temperatures in combustion environments using thermographic phosphors; Wandtemperaturmessungen in Verbrennungsumgebungen mithilfe thermographischer Phosphore

Energy Technology Data Exchange (ETDEWEB)

Bruebach, J.; Kissel, T. [TU Darmstadt (Germany). FG Energie- und Kraftwerkstechnik; Dreizler, A. [TU Darmstadt (Germany). FG Reaktive Stroemungen und Messtechnik

2009-07-01

A phosphor thermometry system was characterised with regard to all sources of systematic errors. Exemplary, the point measurement of a surface temperature and the determination of wall-normal temperature gradients within an optically accessible combustion chamber are outlined. Furthermore, the temporal temperature characteristic at the quartz ring of an optically accessible engine is presented. (orig.)

Simple preparation of LiF:Mg,Ti phosphor

International Nuclear Information System (INIS)

Moharil, S.V.; Shahare, D.I.; Upaded, S.V.; Deshmukh, B.T.

1993-01-01

LiF-TLD 100 is a low-impedance (Z eff = 8.2) tissue equivalent material which is widely used in thermoluminescence (TL) dosimetry of ionizing radiations and personnel monitoring. Mg and Ti have been found to be the major impurities which impart the Tl characteristics. Recipes for the preparation of this phosphor, have not been found to be satisfactory for routine manufacture; there have always been problems associated with reproducibility and even with batch homogeneity. One of the reasons for this is that most procedures start either from readily available LiF or by melting the synthesized LiF, or both. The background impurities in the starting LiF powder can mask the intentional impurities, particularly Ti which has to be doped in rather small concentrations (10 p.p.m.). Melting LiF can again be tricky, as the LiF melt is volatile and highly corrosive. In this letter we report the preparation of LiF: Mg, Ti. The impurities were incorporated during the synthesis of LiF. The phosphor was prepared by heat treatments in ambient air without melting the compound. The characteristics of the prepared phosphors were studied and compared with those of LiF-TLD 100. (author)

Influence of pH-control in phosphoric acid treatment of zinc oxide

Energy Technology Data Exchange (ETDEWEB)

Onoda, H., E-mail: onoda@kpu.ac.jp [Department of Informatics and Environmental Sciences, Kyoto Prefectural University (Japan); Chemel, M. [Ecole de Biologie Industrielle, CERGY Cedex (France)

2017-04-15

Zinc oxide is often used as a white pigment for cosmetics; however, it shows photocatalytic activity that causes decomposition of sebum on the skin when exposed to the ultraviolet radiation in sunlight. In this work, zinc oxide was reacted with phosphoric acid at various pH values to synthesize a novel white pigment for cosmetics. The chemical composition, powder properties, photocatalytic activities, colors, and smoothness of these pigments were studied. The obtained materials exhibited X-ray diffraction peaks relating to zinc oxide and phosphate after phosphoric acid treatment. The ratio of zinc phosphate to zinc oxide was estimated from inductively coupled plasma - atomic emission spectroscopy results. Samples treated at pH 4-7 yielded small particles with sub-micrometer sizes. The photocatalytic activity of zinc oxide became lower after phosphoric acid treatment. Samples treated at pH 4-7 showed the same reflectance as zinc oxide in both the ultraviolet and visible ranges. Adjustment of the pH was found to be important in the phosphoric acid treatment of zinc oxide. (author)

Modeling quantum noise of phosphors used in medical X-ray imaging detectors

CERN Document Server

Kalivas, N; Cavouras, D; Costaridou, L; Nomicos, C D; Panayiotakis, G S

1999-01-01

The noise properties of the granular phosphor screens, which are utilized in X-ray imaging detectors, are studied in terms of the quantum noise transfer function (QNTF). An analytical model, taking into account the effect of K-characteristic X-rays reabsorption within the phosphor material and the optical properties of the phosphor, was developed. The optical properties of the phosphor material required by the model were obtained from literature, except for the optical diffusion length (sigma) that was determined by data fitting and was found to be 26 cm sup 2 /g. The deviation between theoretical and experimental data is sigma depended. Specifically for sigma=26 cm sup 2 /g and sigma=25 cm sup 2 /g the respective deviations between experimental and predicted results were 0.698% and -1.597%. However for relative differences in sigma more than 15% from the value 26 cm sup 2 /g, the corresponding deviations exceed by 6 times the value of 0.698%. The model was tested via comparison to experimental results obtain...

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson′s disease

Directory of Open Access Journals (Sweden)

B K Binukumar

2016-01-01

Full Text Available Cyclin-dependent kinase 5 (Cdk5 is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions. Recent evidence indicates that Cdk5 is inappropriately activated in several neurodegenerative conditions, including Parkinson′s disease (PD. PD is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. During neurotoxicity, p35 is cleaved to form p25. Binding of p25 with Cdk5 leads deregulation of Cdk5 resulting in number of neurodegenerative pathologies. To date, strategies to specifically inhibit Cdk5 hyperactivity have not been successful without affecting normal Cdk5 activity. Here we show that inhibition of p25/Cdk5 hyperactivation through TFP5/TP5, truncated 24-aa peptide derived from the Cdk5 activator p35 rescues nigrostriatal dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP/MPP + in a mouse model of PD. TP5 peptide treatment also blocked dopamine depletion in the striatum and improved gait dysfunction after MPTP administration. The neuroprotective effect of TFP5/TP5 peptide is also associated with marked reduction in neuroinflammation and apoptosis. Here we show inhibition of Cdk5/p25-hyperactivation by TFP5/TP5 peptide, which identifies Cdk5/p25 as a potential therapeutic target to reduce neurodegeneration in PD.

Luminescence behaviors of Eu- and Dy-codoped alkaline earth metal aluminate phosphors through potassium carbonate coprecipitation

Energy Technology Data Exchange (ETDEWEB)

Liang, Chen-Jui, E-mail: cjliang@fcu.edu.tw; Siao, Hao-Yi

2016-07-01

An electronic energy mechanism of activator and sensitizer was established to describe the luminescence behaviors of Eu- and Dy-codoped M(II)Al{sub 2}O{sub 4} (M(II) = Ba, Sr, Ca, Mg) phosphors through potassium carbonate coprecipitation. Experimental results demonstrated that the prepared phosphors exhibited superior crystallinity at a temperature lower than 950 °C. The phosphors are ordered according to emission intensity as follows Ca- > Ba- > Sr- > Mg-containing phosphors. The energy level for Eu{sup 2+} 4f{sup 6}5d{sup 1} → 4f{sup 7}, Eu{sup 3+4}D{sub 0} → {sup 7}F, and Dy{sup 3+4}F{sub 9/2} → {sup 6}H transitions and the effects of nephelauxetic and crystal field in Ba-, Sr-, and Ca-containing phosphors were discussed. The energy gap, (hv){sub em}, between 5d and 4f of Eu{sup 2+} ion is strongly affected by host composition, crystal field strength, and nephelauxetic effect. The infrared emission of 4f{sub 9/2} → 6h for Dy{sup 3+} is merely depend on the transfer of energy from Eu{sup 2+} upon excited. Ca-containing phosphor with maximum (hv){sub em} is attributed to the lowest bond length of Ca−O and highest ionization potential of Ca{sup 2+} ion, which leads to the effects of crystal field and nephelauxetic greater than that in the other phosphors. - Highlights: • The list of the collected figure captions: • Develop a new coprecipitation method to prepare high efficiency phosphors. • Obtain superior crystallinity with lower calcination temperature. • Luminescence behavior of Eu- and Dy-codoped on aluminate phosphors is discussed. • Investigate the effects of alkaline earth metal containing on crystal field and nephelauxetic.

Estimating spatio-temporal dynamics of stream total phosphate concentration by soft computing techniques.

Science.gov (United States)

Chang, Fi-John; Chen, Pin-An; Chang, Li-Chiu; Tsai, Yu-Hsuan

2016-08-15

This study attempts to model the spatio-temporal dynamics of total phosphate (TP) concentrations along a river for effective hydro-environmental management. We propose a systematical modeling scheme (SMS), which is an ingenious modeling process equipped with a dynamic neural network and three refined statistical methods, for reliably predicting the TP concentrations along a river simultaneously. Two different types of artificial neural network (BPNN-static neural network; NARX network-dynamic neural network) are constructed in modeling the dynamic system. The Dahan River in Taiwan is used as a study case, where ten-year seasonal water quality data collected at seven monitoring stations along the river are used for model training and validation. Results demonstrate that the NARX network can suitably capture the important dynamic features and remarkably outperforms the BPNN model, and the SMS can effectively identify key input factors, suitably overcome data scarcity, significantly increase model reliability, satisfactorily estimate site-specific TP concentration at seven monitoring stations simultaneously, and adequately reconstruct seasonal TP data into a monthly scale. The proposed SMS can reliably model the dynamic spatio-temporal water pollution variation in a river system for missing, hazardous or costly data of interest. Copyright © 2016 Elsevier B.V. All rights reserved.

Developing Quantum Dot Phosphor-Based Light-Emitting Diodes for Aviation Lighting Applications

International Nuclear Information System (INIS)

Wu, F.; Dawei, Z.; Shuzhen, S.; Yiming, Z.; Songlin, Z.; Jian, X.

2012-01-01

We have investigated the feasibility of employing quantum dot (QD) phosphor-based light-emitting diodes (LEDs) in aviation applications that request Night Vision Imaging Systems (NVIS) compliance. Our studies suggest that the emerging QD phosphor-based LED technology could potentially be superior to conventional aviation lighting technology by virtue of the marriage of tight spectral control and broad wavelength tunability. This largely arises from the fact that the optical properties of semiconductor nano crystal QDs can be tailored by varying the nano crystal size without any compositional changes. It is envisioned that the QD phosphor-based LEDs hold great potentials in cockpit illumination, back light sources of monitor screens, as well as the LED indicator lights of aviation panels.

Chemical process for recovery of uranium values contained in phosphoric mineral lixivia

International Nuclear Information System (INIS)

Conceicao, E.L.H. da; Awwal, M.A.; Coelho, S. V.

1980-01-01

A recovery process of uranium values from phosporic mineral lixivia for obtaining uranio oxide concentrate adjusted to specifications of purity for its commercialization the process consists of the adjustment of electromotive force of lixiviem to suitable values for uranium extraction, extraction with organic solvent containing phosphoric acid ester and oxidant reextraction from this solvent with phosphoric acid solution, suggesting a new solvent extraction containing synergetic mixture of di-2-ethyl hexyl phosphoric acid and tri-octyl phosphine, leaching this solvent with water and re-extraction/precipitation with ammonium carbonate solution, resulting in the formation of uranyl tricarbonate and ammonium, that by drying and calcination gives the uranium oxide with purity degree for commercialization. (M.C.K.) [pt

Combustion synthesis of Eu and Dy activated Sr3(VO4)2 phosphor ...

Indian Academy of Sciences (India)

phosphor as well as Sr3(VO4)2:Dy is blue and yellow emitting phosphor for solid state lighting i.e. white LEDs. The ... 2004; Pang et al 2004) doped with rare earth has expanded ... controlled since the LED light output (intensity and colour).

Evaluation of characteristics of x-ray phosphors and hybrid scintillators

International Nuclear Information System (INIS)

Winter, John M. Jr.; Jones, Thomas S.

1999-01-01

Glass x-ray scintillators produce very high resolution images but suffer diminished brightness at x-ray energies below about 150 kV. This produces a loss in effective imaging due to the very low light flux, just at energies where many high resolution applications require the maximum image fidelity. Many phosphors produce substantially more light at these energy levels, but lack the resolution needed for critical industrial applications. A family of hybrid scintillators consisting of a scintillating fiber-optic base coupled to a thin coating of a high resolution phosphor is being developed. To facilitate evaluation of these hybrids and to measure their performance compared to other alternatives, a specialized real time x-ray imaging system was constructed and integrated with a microfocus x-ray source. This imaging system is described, and the results of a program to evaluate the brightness, resolution, and contrast sensitivity of a number of glass scintillators, phosphors, and hybrid imaging screens is presented

Luminescence studies on phosphor screens

International Nuclear Information System (INIS)

Panayiotakis, G.; Nomikos, C.; Bakas, A.; Proimos, B.

1994-01-01

We report our results on x-ray phosphor screens prepared of some new materials focusing attention on their efficiency under fluoroscopy conditions, on optimization conditions and on comparisons among the various materials. All data are presented in absolute values. A theoretical model is presented, that takes into account the granular structure of the screens, permitting the explanation and prediction of the luminescence properties of the screens. (authors)

Blood Chemistry Reference Values for Free-Ranging Asiatic Black Bears ( Ursus thibetanus) by Season, Age, and Sex.

Science.gov (United States)

Yang, Jeong-Jin; Jeong, Dong-Hyuk; Lim, Yoon-Kyu

2018-04-19

Physiological characteristics, such as blood chemistry values, are valuable for evaluating the health of the animals. To our knowledge, these values have never been reported for the free-ranging Asiatic black bear ( Ursus thibetanus; ABB). Thus, 28 blood chemistry values from 50 free-ranging ABBs captured in Jirisan National Park, Republic of Korea, from 2005 to 2016 were evaluated. The aim of this study was to establish blood chemistry reference values for the free-ranging ABBs during both the hibernating and nonhibernating seasons. During hibernation, mean values of creatinine (CRE), total cholesterol, total protein (TP), albumin (ALB), triglycerides, and Mg were significantly higher than those during nonhibernation; however, mean values of blood urea nitrogen, urea nitrogen to creatinine (U/C) ratio, inorganic phosphorous (IP), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, lactate dehydrogenase (LDH), high-density lipoprotein cholesterol, and alkaline phosphatase (ALP) were significantly lower. Age differences (young vs. adult) were found in IP, LDH, TP, and ALB values during hibernation and in the U/C ratio, Ca, IP, ALP, creatine kinase myocardial band, CRE, total bilirubin, and uric acid values during nonhibernation. However, there were no sex differences (male vs. female).

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.

Science.gov (United States)

Fischer, Martin; Grossmann, Patrick; Padi, Megha; DeCaprio, James A

2016-07-27

Cell cycle (CC) and TP53 regulatory networks are frequently deregulated in cancer. While numerous genome-wide studies of TP53 and CC-regulated genes have been performed, significant variation between studies has made it difficult to assess regulation of any given gene of interest. To overcome the limitation of individual studies, we developed a meta-analysis approach to identify high confidence target genes that reflect their frequency of identification in independent datasets. Gene regulatory networks were generated by comparing differential expression of TP53 and CC-regulated genes with chromatin immunoprecipitation studies for TP53, RB1, E2F, DREAM, B-MYB, FOXM1 and MuvB. RNA-seq data from p21-null cells revealed that gene downregulation by TP53 generally requires p21 (CDKN1A). Genes downregulated by TP53 were also identified as CC genes bound by the DREAM complex. The transcription factors RB, E2F1 and E2F7 bind to a subset of DREAM target genes that function in G1/S of the CC while B-MYB, FOXM1 and MuvB control G2/M gene expression. Our approach yields high confidence ranked target gene maps for TP53, DREAM, MMB-FOXM1 and RB-E2F and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Identification of operator sites of the CI repressor of phage TP901-1: evolutionary link to other phages

International Nuclear Information System (INIS)

Johansen, Annette H.; Broendsted, Lone; Hammer, Karin

2003-01-01

The repressor encoded by the cI gene of the temperate Lactococcus lactis subsp. cremoris bacteriophage TP901-1 has been purified. Gel-retardation and footprinting analyses identified three palindromic operator sites (O R , O L , and O D ). The operator site O R is located between the two divergent early promoters P R and P L , O L overlaps the transcriptional start of the lytic P L promoter, and O D is located downstream of the mor gene, the first gene in the lytic gene cluster. The function of O L was verified by mutational analysis. Binding was found to be specific and cooperative. Multimeric forms of the repressor were observed, thus indicating that the repressor may bind simultaneously to all three operator sites. Inverted repeats with homology to the operator sites of TP901-1 were identified in phage genomes encoding repressors homologous to CI of TP901-1. Interestingly, the locations of these repeats on the phage genomes correspond to those found in TP901-1, indicating that the same system of cooperative repression of early phage promoters has been inherited by modular evolution

Photoluminescence studies of organic phosphor coated diffusing surface using blue inorganic light-emitting diode as excitation source

International Nuclear Information System (INIS)

Singh, Gyanendra; Mehta, Dalip Singh

2013-01-01

We report the studies on photoluminescence (PL) of organic phosphor coated on a diffusing surface using a blue inorganic light-emitting diode (LED) array as an excitation source. The organic phosphor composite coated diffuser was used to scatter the directional blue light from the LED array. Some of the blue light is absorbed by the organic phosphor composite and the phosphor molecules are excited and re-emit light at longer wavelengths due to the PL process. The output light consists of scattered blue light plus phosphor generated broadband yellow light, thus making white light. The diffuser was made up of a plastic substrate coated with an organic composite of small molecule fluorescent material zinc(II)bis(8-hydroxyquinoline) (Znq 2 ) doped with different percentages of electro-phosphorescent metal complex iridium(III)bis(2-methyldibenzo-[f, h] quinoxaline) (acetylacetonate) ([Ir(MDQ) 2 (acac)]). By means of changing the concentration and the thickness of the phosphor composite material the colour coordinates of white light were achieved. The CIE coordinates and correlated colour temperature were calculated for various thicknesses and phosphor composite concentrations and the results are reported. (paper)

Calculated energy dependence of CaSO4:Dy TL phosphor and phosphor embedded Teflon for X and gamma rays

International Nuclear Information System (INIS)

Chang, J.-K.; Nam, Y.-M.; Kim, J.-L.; Chang, S.-Y.; Kim, B.-H.

2001-01-01

The energy dependence of a CaSO 4 :Dy TL phosphor for 21 monoenergetic photons of energy ranging from 0.01 to 3 MeV was calculated by using MCNP4A code. The calculation results show good agreement with those of other authors within ± 5% relative error. Calculations and experiments are also performed to determine the energy dependence of CaSO 4 : Dy phosphor with Dy concentrations from 0.01 to 1.5 mol %, and with the compositions of TL-Teflon from 10 to 90 wt %. The calculated energy responses show good agreement with the experiment results within ± 20% relative error except for a concentration lower than 0.1 mol % Dy and the low energy regions of M30 (Eave.=20 keV) and M60 (Eave.=34 keV). For the TL-Teflon mixture, the energy dependence shows an decreasing trend with the increase of Teflon concentration in MCNP calculation but shows no dependence for TL-Teflon mixture proportions in experiment. These differences are due to the non-homogeneous distribution of Dy concentration and the effect of large grain size in the phosphors. The energy dependence of the 30 wt/o CaSO 4 (0.1 mol%;Dy) and 70 wt/o Teflon that is placed behind the filters of plastic, aluminum, copper, tin and lead with a thickness from 0.1 to 2 mm were calculated, respectively

Porous structure and surface chemistry of phosphoric acid activated carbon from corncob

International Nuclear Information System (INIS)

Sych, N.V.; Trofymenko, S.I.; Poddubnaya, O.I.; Tsyba, M.M.; Sapsay, V.I.; Klymchuk, D.O.; Puziy, A.M.

2012-01-01

Highlights: ► Phosphoric acid activation results in formation of carbons with acidic surface groups. ► Maximum amount of surface groups is introduced at impregnation ratio 1.25. ► Phosphoric acid activated carbons show high capacity to copper. ► Phosphoric acid activated carbons are predominantly microporous. ► Maximum surface area and pore volume achieved at impregnation ratio 1.0. - Abstract: Active carbons have been prepared from corncob using chemical activation with phosphoric acid at 400 °C using varied ratio of impregnation (RI). Porous structure of carbons was characterized by nitrogen adsorption and scanning electron microscopy. Surface chemistry was studied by IR and potentiometric titration method. It has been shown that porosity development was peaked at RI = 1.0 (S BET = 2081 m 2 /g, V tot = 1.1 cm 3 /g), while maximum amount of acid surface groups was observed at RI = 1.25. Acid surface groups of phosphoric acid activated carbons from corncob includes phosphate and strongly acidic carboxylic (pK = 2.0–2.6), weakly acidic carboxylic (pK = 4.7–5.0), enol/lactone (pK = 6.7–7.4; 8.8–9.4) and phenol (pK = 10.1–10.7). Corncob derived carbons showed high adsorption capacity to copper, especially at low pH. Maximum adsorption of methylene blue and iodine was observed for carbon with most developed porosity (RI = 1.0).

Porous structure and surface chemistry of phosphoric acid activated carbon from corncob

Energy Technology Data Exchange (ETDEWEB)

Sych, N.V.; Trofymenko, S.I.; Poddubnaya, O.I.; Tsyba, M.M. [Institute for Sorption and Endoecology Problems, National Academy of Sciences of Ukraine, 13 General Naumov St., 03164 Kyiv (Ukraine); Sapsay, V.I.; Klymchuk, D.O. [M.G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, 2 Tereshchenkivska St., 01601 Kyiv (Ukraine); Puziy, A.M., E-mail: alexander.puziy@ispe.kiev.ua [Institute for Sorption and Endoecology Problems, National Academy of Sciences of Ukraine, 13 General Naumov St., 03164 Kyiv (Ukraine)

2012-11-15

Highlights: Black-Right-Pointing-Pointer Phosphoric acid activation results in formation of carbons with acidic surface groups. Black-Right-Pointing-Pointer Maximum amount of surface groups is introduced at impregnation ratio 1.25. Black-Right-Pointing-Pointer Phosphoric acid activated carbons show high capacity to copper. Black-Right-Pointing-Pointer Phosphoric acid activated carbons are predominantly microporous. Black-Right-Pointing-Pointer Maximum surface area and pore volume achieved at impregnation ratio 1.0. - Abstract: Active carbons have been prepared from corncob using chemical activation with phosphoric acid at 400 Degree-Sign C using varied ratio of impregnation (RI). Porous structure of carbons was characterized by nitrogen adsorption and scanning electron microscopy. Surface chemistry was studied by IR and potentiometric titration method. It has been shown that porosity development was peaked at RI = 1.0 (S{sub BET} = 2081 m{sup 2}/g, V{sub tot} = 1.1 cm{sup 3}/g), while maximum amount of acid surface groups was observed at RI = 1.25. Acid surface groups of phosphoric acid activated carbons from corncob includes phosphate and strongly acidic carboxylic (pK = 2.0-2.6), weakly acidic carboxylic (pK = 4.7-5.0), enol/lactone (pK = 6.7-7.4; 8.8-9.4) and phenol (pK = 10.1-10.7). Corncob derived carbons showed high adsorption capacity to copper, especially at low pH. Maximum adsorption of methylene blue and iodine was observed for carbon with most developed porosity (RI = 1.0).

Dosimetry characteristics of thermoluminescent Li2B4O7:Cu phosphor

International Nuclear Information System (INIS)

Lakshmanan, A.R.; Chandra, B.; Bhatt, R.C.

1981-01-01

Preliminary investigations on the radiation dosimetry characteristics of Li 2 B 4 O 7 :Cu TLD phosphor are described. The major TL peak in this phosphor occurs at 230 0 C and its TL sensitivity to gamma radiation is two to three times higher than that of LiF TLD-100. The gamma dose Vs TL response of this peak is linear (within +- 20%) in the dose range 0.3 mGy-3x10 2 Gy above which saturation sets in. Its TL response for 30 keV X-rays is about 20% lower than that for 60 Coγ-rays. On annealing at 300 0 C, the phosphor gets slightly discoloured (brownish). This results in the reduction of the TL sensitivity by about 20 - 25%. The phosphor does not exhibit either sensitization or damage even after a gamma dose of 10 3 Gy. The TL emission spectrum has a broad peak at 360 nm. The intrinsic TL sensitivity of virgin Li 2 B 4 O 7 :Cu to 253.7 nm UV radiation is nearly 50 times higher than that of CaSO 4 :Dy. The post-irradiation fading in Li 2 B 4 O 7 :Cu at ambient temperature and humidity conditions is, however, less than 10% in 17 days. These characteristics indicate that Li 2 B 4 O 7 :Cu is a promising phosphor for ionizing as well as UV radiation dosimetry. (author)

Reactivity of the cadmium ion in concentrated phosphoric acid solutions.

Science.gov (United States)

De Gyves, J; Gonzales, J; Louis, C; Bessiere, J

1989-07-01

The solvation transfer coefficients which characterize the changes of ion reactivity with phosphoric acid concentration have been calculated for cadmium from the constants of the successive chloride complexes, and for silver and diethyldithiophosphate from potentiometric measurements. They evidence the strong desolvation of the cadmium species in concentrated phosphoric acid media, causing a remarkable increase of its reactivity. They allow the results of liquid-liquid extraction, precipitation and flotation reactions to be correctly interpreted and their changes to be foreseen when the reagents are modified.

Synthesis and luminescent properties of Sm3+ doped zinc aluminate phosphor

Science.gov (United States)

Mahajan, Rubby; Kumar, Sandeep; Prakash, Ram; Kumar, Vinay

2018-05-01

Zinc Aluminate (ZnAl2O4) is a well-known wide band gap oxide that belongs to a class of mixed-metal oxides knows as spinels (AB2O4) where A and B are divalent and trivalent cations. Herein, the structural and photoluminescence properties of Sm3+ ion doped with ZnAl2O4 phosphors are reported. The nanophosphors were synthesized via solution combustion synthesis route at temperature 570 °C. The synthesized samples were characterized by X-ray powder diffraction (XRD), Photoluminescence (PL) spectroscopy, and Ultraviolet-visible spectroscopy. The XRD pattern confirms the cubic phase of phosphor. The calculated lattice parameter were found as a = b = c = 8.0517Å and V = 521.85Å3. The crystallite size of the phosphor was calculated using the Debye-Scherrer formula and found to be ˜19 nm. The emission spectrum at excitation wavelength of 401 nm gave the emission peaks at 563 nm, 601 nm, 648 nm, 697 nm corresponding to the transitions 4G5/2→ 6H5/2, 4G5/2→6H7/2, 4G5/2→6H9/2, 4G5/2 → 6H11/2 of Sm3+ ions, respectively. The diffuse reflectance spectrum was used to calculate the band gap of material and found to be 5.12 eV. The CIE coordinates were found to be (x = 0.56, y = 0.40) that falls in the orange red region of the color gamut. The present phosphor may have potential applications as phosphor for near UV WLED for solid state lighting.

A Visual Detection System for Determining Tritium Surface Deposition Employing Phosphor Coated Materials

International Nuclear Information System (INIS)

Gentile, C.A.; Skinner, C.H.; Young, K.M.; Zweben, S.J.

1999-01-01

A method for visually observing tritium deposition on the surface of the Tokamak Fusion Test Reactor (TFTR) deuterium-tritium (D-T) tiles is being investigated at the Princeton Plasma Physics Laboratory. A green phosphor (P31, zinc sulfide: copper) similar to that used in oscilloscope screens with a wavelength peak of 530 nm was positioned on the surface of a TFTR D-T tile. The approximately 600 gram tile, which contains approximately 1.5 Ci of tritium located on the top approximately 1-50 microns of the surface, was placed in a two liter lexan chamber at Standard Temperature and Pressure (STP). The phosphor plates and phosphor powder were placed on the surface of the tile which resulted in visible light being observed, the consequence of tritium betas interacting with the phosphor. This technique provides a method of visually observing varying concentrations of tritium on the surface of D-T carbon tiles, and may be employed (in a calibrated system) to obtain quantitative data

Investigation of thermoluminescence and electron-vibrational interaction parameters in SrAl2O4:Eu2+, Dy3+ phosphors

International Nuclear Information System (INIS)

Pardhi, Shilpa A.; Nair, Govind B.; Sharma, Ravi; Dhoble, S.J.

2017-01-01

Combustion synthesis method was employed for the synthesis of green-emitting monoclinic SrAl 2 O 4 :Eu 2+ , Dy 3+ phosphors. The phase-purity of the prepared phosphors were examined using X-ray diffraction (XRD). The prepared phosphors exhibited green light emission with the peak centred at 510 nm, under 350 nm UV excitation. The excitation and emission spectra were analysed and the parameters of electron-vibrational interaction (EVI), such as the Huang–Rhys factor, effective phonon energy and zero-phonon line position were estimated using the spectrum fitting method. Thermoluminescence (TL) behaviour of the as-prepared phosphors were analysed for UV and 137 Cs γ-ray source irradiation. TL glow curves for UV-irradiated SrAl 2 O 4 :Eu 2+ , Dy 3+ phosphors were analysed. - Highlights: • Photoluminescence and thermoluminescence properties of SrAl 2 O 4 :Eu 2+ ,Dy 3+ phosphors were analysed. • Electron-vibrational interaction (EVI) parameters of SrAl 2 O 4 :Eu 2+ ,Dy 3+ phosphors were determined. • The phosphors are found to exhibit green light emission.