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Sample records for tomotoshi ishitobi guebuem

  1. Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients

    Directory of Open Access Journals (Sweden)

    Tanaka Y

    2013-12-01

    Full Text Available Yoshihiro Tanaka, Yoshihiro Maruyama, Yoshinobu Ishitobi, Aimi Kawano, Tomoko Ando, Rie Ikeda, Ayako Inoue, Junko Imanaga, Shizuko Okamoto, Masayuki Kanehisa, Taiga Ninomiya, Jusen Tsuru, Jotaro Akiyoshi Department of Neuropsychiatry, Faculty of Medicine, Oita University, Hasama-Machi, Oita, Japan Background: Bipolar disorder (BP is often associated with a change in hypothalamus–pituitary–adrenal axis function change due to chronic stress. Salivary α-amylase (sAA levels increase in response to psychosocial stress and thus function as a marker of sympathoadrenal medullary system activity. However, sAA has been studied less often than salivary cortisol in BP patients. Method: We measured Profile of Mood States and State-Trait Anxiety Inventory scores, heart rate variability, and salivary cortisol levels during electrical stimulation stress in 25 BP patients and 22 healthy volunteers. Results: Tension–anxiety, depression–dejection, anger–hostility, fatigue, and confusion scores in BP patients significantly increased compared with those of the healthy controls. In contrast, the vigor scores of BP patients significantly decreased compared with those of the healthy controls. Significant difference in the sAA levels was observed between BP patients and healthy controls. sAA of female patients was significantly higher than that of female healthy controls, and sAA in male patients tended to be higher than that of male healthy controls. No difference in salivary cortisol was observed between BP patients and the healthy controls. Only three time points were measured before and after the electrical stimulation stress. Furthermore, sAA secretion by BP patients increased before and after electrical stimulation. Conclusion: These preliminary results suggest that sAA may be a useful biological marker for BP patients. Keywords: HPA axis, bipolar disorder, α-amylase, cortisol, SAM activity

  2. The geographical conditions of intensity of salty waters intrusions to coastal lakes on Polish Southern Baltic coast

    Science.gov (United States)

    Cieslinski, R.

    2009-04-01

    Lakes situated on the coast of the southern Baltic function in different conditions than those in which typically inland reservoirs occur. They are situated in the contact zone of two environments: land and sea. These reservoirs together with their direct catchments form specific hydrographic arrangement, in which the course of physical, chemical and biological processes depends on the fact which of these two environments exerts a stronger influence at a given moment. This is important as the lakes situated in the shore zone of the southern Baltic are not exposed to phenomena caused by constant tides, as it is the case in open seas (Ataie-Ashtiani et al., 1999), but only to extreme hydrometeorological conditions, which lead to the formation of the phenomenon of intrusions of sea waters and of damming the free outflow of potamic waters (Demirel, 2004; Cieśliński, Drwal, 2005). What should also be remembered are the local hydrographic, hydrological and morphometric conditions. As a result of intrusions, in the waters of coastal lakes, apart from inland waters there are also waters of sea origin. The proportions of these genetically distinct waters are variable and differ in individual lakes (Grassi, Netti, 2000; Drwal, Cieśliński, 2007). Despite the difference in the causal factor triggering the phenomenon of salt water intrusions, the effect is usually the same as that observed, for instance, in lakes and lagoons of seas with tides (Ishitobi et al., 1999; De Louw, Oude Essink, 2001) and poorly flushed lagoon (Hsing-Juh et al., 2006) or estuaries (Uncles et al., 2002), though the scale of qualitative changes is greater in the case of open seas than in half-closed and closed seas. The status of the research carried out so far enables proposing a hypothesis that chlorides concentrations, as the best indicators for establishing the occurrence of the phenomenon of intrusions, depend not only on the meteorological factor but in some of the lakes on various