Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

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Akiyoshi, Jotaro; Tsuru,Jusen; Tanaka,Yoshihiro; Ishitobi,Yoshinobu; Maruyama,Yoshihiro; Inoue,Ayako; Kawano,Aimi; Ikeda,Rie; Ando,Tomoko; Oshita,Harumi; Aizawa,Saeko; Masuda,Koji; Higuma,Haruka; Kanehisa,Masayuki; Ninomiya,Taiga

2014-01-01

Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val...

Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

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Tsuru J

2014-11-01

Full Text Available Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men using a social stress procedure (Trier Social Stress Test [TSST] and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A.Results: A significant three-way interaction (time [3 levels] × BDNF [Val/Val, Val/Met, Met/Met]; P<0.05 was demonstrated that revealed different salivary cortisol responses in the TSST but not in electrical stimulation. Met/Met women had stronger cortisol responses than Val/Met and Val/Val individuals in the TSST. Met/Met men exhibited stronger salivary cortisol responses than Val/Met and Val/Val individuals in the TSST.Conclusion: These results indicate that a common, functionally significant polymorphism in BDNF had different effects on hypothalamic–pituitary–adrenocortical axis reactivity but not on sympathetic adrenomedullary reactivity in TSST and electrical stimulation tests. Keywords: stress, brain-derived neurotrophic factor, cortisol, saliva

The geographical conditions of intensity of salty waters intrusions to coastal lakes on Polish Southern Baltic coast

Science.gov (United States)

Cieslinski, R.

2009-04-01

Lakes situated on the coast of the southern Baltic function in different conditions than those in which typically inland reservoirs occur. They are situated in the contact zone of two environments: land and sea. These reservoirs together with their direct catchments form specific hydrographic arrangement, in which the course of physical, chemical and biological processes depends on the fact which of these two environments exerts a stronger influence at a given moment. This is important as the lakes situated in the shore zone of the southern Baltic are not exposed to phenomena caused by constant tides, as it is the case in open seas (Ataie-Ashtiani et al., 1999), but only to extreme hydrometeorological conditions, which lead to the formation of the phenomenon of intrusions of sea waters and of damming the free outflow of potamic waters (Demirel, 2004; Cieśliński, Drwal, 2005). What should also be remembered are the local hydrographic, hydrological and morphometric conditions. As a result of intrusions, in the waters of coastal lakes, apart from inland waters there are also waters of sea origin. The proportions of these genetically distinct waters are variable and differ in individual lakes (Grassi, Netti, 2000; Drwal, Cieśliński, 2007). Despite the difference in the causal factor triggering the phenomenon of salt water intrusions, the effect is usually the same as that observed, for instance, in lakes and lagoons of seas with tides (Ishitobi et al., 1999; De Louw, Oude Essink, 2001) and poorly flushed lagoon (Hsing-Juh et al., 2006) or estuaries (Uncles et al., 2002), though the scale of qualitative changes is greater in the case of open seas than in half-closed and closed seas. The status of the research carried out so far enables proposing a hypothesis that chlorides concentrations, as the best indicators for establishing the occurrence of the phenomenon of intrusions, depend not only on the meteorological factor but in some of the lakes on various