WorldWideScience

Sample records for tlkinud marek laane

  1. VanderLaan Circulant Type Matrices

    Directory of Open Access Journals (Sweden)

    Hongyan Pan

    2015-01-01

    Full Text Available Circulant matrices have become a satisfactory tools in control methods for modern complex systems. In the paper, VanderLaan circulant type matrices are presented, which include VanderLaan circulant, left circulant, and g-circulant matrices. The nonsingularity of these special matrices is discussed by the surprising properties of VanderLaan numbers. The exact determinants of VanderLaan circulant type matrices are given by structuring transformation matrices, determinants of well-known tridiagonal matrices, and tridiagonal-like matrices. The explicit inverse matrices of these special matrices are obtained by structuring transformation matrices, inverses of known tridiagonal matrices, and quasi-tridiagonal matrices. Three kinds of norms and lower bound for the spread of VanderLaan circulant and left circulant matrix are given separately. And we gain the spectral norm of VanderLaan g-circulant matrix.

  2. Pudemed möödunud aegade kroonikast / Marek Laane

    Index Scriptorium Estoniae

    Laane, Marek, 1969-

    2002-01-01

    Esimene Peter Jacksoni käe all valmivast kolmest filmist J.R.R. Tolkieni triloogia "Sõrmuste isand" alusel - "Sõrmuse vennaskond", "The Lord of the Rings : The Fellowship of the Ring" : Uus-Meremaa, Ameerika Ühendriigid 2001

  3. Eesti vajab terasemat valitsust / tõlk. Marek Laane

    Index Scriptorium Estoniae

    2007-01-01

    Briti mõjukas majandusajakiri Economist kirjutas oma veebiväljaandes Eesti edust 1990. aastatel. Kuid parlamendivalimised näitasid, et Eestis nagu teistes endistes kommunistlikes maades puudub reformialdis valitsus. Kiitust pälvib Eesti president Toomas Hendrik Ilves, kes pani veto pronkssõduri seadusele ja taunis Eesti iseseisvuspäeva pidustustel peetud kõnes korruptsiooni, enesega rahulolu ja takerdunud reforme. Kommenteerivad Eesti Konjunktuuriinstituudi juhtiv teadur Leev Kuum, SEB Ühispanga analüütik Hardo Pajula, majandusministri nõunik Heido Vitsur ja peaministri nõunik Taavi Rõivas

  4. Euroopa unelm / Jeremy Rifkin ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Rifkin, Jeremy

    2006-01-01

    Autori hinnangul võiksid ameeriklased eurooplastelt õppida solidaarsust, kaasatust, elukvaliteeti, jätkusuutlikku arengut ja rahu, eurooplased aga ameeriklastelt isiklikku vastutamist, lootusetunnet, optimismi ning riskimist. Vt. samas lk. 34-37 Linnar Viigi ja Jeremy Rifkini diskussiooni

  5. Aasta pärast terrorit / Marek Laane

    Index Scriptorium Estoniae

    Laane, Marek, 1969-

    2002-01-01

    Autor analüüsib Iraani ajaloolaste Ladani ja Roya Bornmandi artiklis "Terror, islam ja demokraatia", Samuel Huntingtoni teoses "Tsivilisatsioonide kokkupõrge", Bobitti raamatus "Shield of Achilles. War, Peace and the Cource of History" esitatud seisukohti. Pärast septembriterrorit on analüütikute hinnangul radikalismi osa islamiilmas kahanenud

  6. Minu isa Aleksander Rudolf Laane / Merike Poljakov

    Index Scriptorium Estoniae

    Poljakov, Merike

    2012-01-01

    Aleksander Rudolf Laane oli viiekordne Eesti meister tõstmise keskkaalus ajavahemikus 1937-1944. Keerukast saatusest metsavennana aastail 1944-1949. Aleskander Rudolf Laane elust vangina Venemaal, mis lõppes amnestiaga 1958. aastal. Elamisloa Eestis sai ta aga alles paljude aastate pärast

  7. Sotsiaaldemokraatia taassünd Eestis / Tony Blair ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Blair, Tony, 1953-

    2004-01-01

    Ilmunud ka: Molodjozh Estonii, 9. veebr. 2004, lk. 3, lüh. Suurbritannia peaminister tervitab Mõõdukate kongressi ja sotsiaaldemokraatide taasärkamist ning kirjeldab parteide ja riikide koostöövõimalusi ühises Euroopas

  8. Eesti-Vene suhetes pole paranemist oodata / Jevgeni Volk ; interv. Marek Laane

    Index Scriptorium Estoniae

    Volk, Jevgeni

    1999-01-01

    Prognoosid Venemaa Riigiduuma valimistulemustele. Eesti-Vene suhted pärast Venemaa presidendi- ja parlamendivalimisi. Venemaa suhtumine Eesti liitumisse NATO ja ELiga. Venemaa ja USA suhted. Kommenteerivad Vladimir RõZhkov, Sergei Kirijenko, Mihhail Gorbatshov, Vladimir Zhirinovski

  9. Auahnus ja mitmemõttelisus / Tiago Marques ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Marques, Tiago

    2007-01-01

    Autor vaatleb arenguid, mida võib Euroopa Liidule tuua Portugal eesistujamaana ja leiab, et koos uue Euroopa Liidu lepingu eeldatava heakskiitmisega esitab Portugali programmile suurima väljakutse Euroopa Liidu ja Aafrika tippkohtumine

  10. Mida teha tumeda minevikuga? / Bruno Groppo ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Groppo, Bruno

    2005-01-01

    Autor keskendub küsimusele, kuidas trauma üle elanud ühiskond peaks oma minevikust üle saama, kui tingimused riigis normaliseeruvad, ning käsitleb lähemalt sellega seonduvalt olukorda Argentinas, Tšiilis, Venemaal

  11. Jaapan nõuab Ühendriikidelt hukkunud laeva ülestõstmist / Marek Laane

    Index Scriptorium Estoniae

    Laane, Marek, 1969-

    2001-01-01

    Hawaii lähistel õppustel kiiret pinnaletõusu harjutanud USA allveelaev Greeneville põrkas kokku Jaapani õppelaevaga Ehime Maru, õnnetuse tagajärjel hukkus tõenäoliselt 9 jaapanlast. Skeem: USA allveelaev uputas Jaapani laeva

  12. Baltimaad - kas "uue" Euroopa esmaasukad? / Jeroen Bult ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Bult, Jeroen

    2005-01-01

    Ajakirjanikud, teadlased ja rahvusvaheliste suhete analüütikud kasutavad "vana" ja "uue" Euroopa metafoori oma arutlustes Atlandi üleste pingete, Euroopa Liidu praeguse halvatuse ning sotsiaalmajanduslike probleemide üle, millega seisavad silmitsi EL-i suuremad liikmesriigid. See jaotus on omamoodi aluseks ka raamatule "The Baltic States And Their Region. New Europe Or Old? ". Raamatu aluseks on 2004. a. Glasgow's peetud samanimeline konverents

  13. Islam ja sõnavabadus - Euroopa lõhestajad / Jeroen Bult ; tõlkinud Marek Laane

    Index Scriptorium Estoniae

    Bult, Jeroen, 1971-

    2008-01-01

    Autor võrdleb Taani karikatuuriskandaali tagajärgi Hollandis valminud islamiteemalise filmi "Fitna" põhjustatud pahameelega ja leiab, et mitte kõik Euroopa poliitikud ei ole veendunud sõnavabaduse kaitsmise vajaduses

  14. Eesti-Vene kompleks / Jeroen Bult ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Bult, Jeroen, 1971-

    2007-01-01

    Rahvusvaheliste sotsiaaluuringute analüütik kirjutab Eesti keeldumisest anda luba Nord Streamile uuringute tegemiseks Eesti majandustsoonis, Eesti, Vene ja Saksa suhetest ja leiab, et uuringuloa andmisega merepõhja uuringuteks oleks Eesti saanud tihendada sidemeid EL-i suurima riigi Saksamaaga

  15. Euroopa halvavad ja ohtlikud ummikteed / Jeroen Bult ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Bult, Jeroen

    2005-01-01

    Prantsusmaa ja Hollandi negatiivsed hääletustulemused Euroopa Liidu põhiseadusliku leppe osas ja 2007-2013. aasta eelarvevaidlused on viinud Euroopa Liidu sügavasse kriisi, mille tagajärjel ei suudeta tõenäoliselt välja töötada ega kasutusele võtta ühist välis- ja kaitsepoliitikat. Seetõttu võib Euroopa Liidust võib kujuneda pelk vabakaubandustsoon

  16. USA peab senist kurssi jätkama / Colin L. Powell ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Powell, Colin L.

    2003-01-01

    USA riigisekretär Colin Powell kinnitab, et Ameerika Ühendriikidel tuleb Iraagis ja Afganistanis jätkata demokratiseerimispoliitikat. Artikkel on kirjutataud Colin Powelli 10. nov. City College of New Yorkis peetud kõne põhjal

  17. Saudi rahuplaan ajas Iisraeli juhid tülli / Marek Laane

    Index Scriptorium Estoniae

    Laane, Marek, 1969-

    2002-01-01

    Saudi Araabia esitatud Lähis-Ida rahuplaan on ajanud Iisraeli juhtkonna tülli: peaminister Ariel Sharon on selle vastu, president Moshe Katsar on aga valmis saudidega kohtuma. Kaart: Iisraeli muutuvad piirid

  18. Surra Tallinna eest / Patrick J. Buchanan ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Buchanan, Patrick J.

    2007-01-01

    USA presidendikandidaat kirjutab Venemaa-Eesti konfliktist pronkssõduri pärast ja võimalikust Venemaa rünnakust Eesti vastu ning arvab, et USA ei peaks, hoolimata NATO põhimõttest, sekkuma, sest see tooks kaasa veel suurema sõja

  19. Iisraeli sõjavägi asus ründama Palestiina omavalitsuse linnu / Marek Laane

    Index Scriptorium Estoniae

    Laane, Marek, 1969-

    2000-01-01

    Iisrael asus rünnakule pärast sõdurite tapmist palestiinlaste poolt. Pinged Lähis-Idas tõstsid nafta hinna viimase kümne aasta kõrgeimale tasemele. Kaart: Iisraeli rünnakud Palestiina sihtmärkide pihta

  20. Energiasõltumatuse ohtlik fantaasia / A. F. Alhajji, Gavin Longmuir ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Alhajji, A. F.

    2007-01-01

    Autorid leiavad, et maailmas üha häälekamalt kõlav soov taotleda energiasõltumatust on absurdne, sest selle poole püüdlevate maade energeetiline julgeolek tegelikult väheneb. Kommenteerib energeetikaekspert Raivo Vare

  1. Varayti at Varyasyon ng Wikang B’laan sa Bacong, Tulunan, Hilagang Cotabato at Lampitak, Tampakan, Timog Cotabato, Philippines

    Directory of Open Access Journals (Sweden)

    Radji A. Macatabon

    2016-08-01

    Full Text Available The study was conducted to determine the variety and variation of B’laan language in two municipalities. Specifically the study aimed to find out the following: What are the variety of B’laan language? Are there lexical and morphological variations existing in B’laan language by B’laan tribe in Bacong, Tulunan North Cotabato and Lampitak, Tampakan South Cotabato? And What factor influences such linguistic variety and variation of B’laan language? The scope of this study was confined to B’laan tribe living in barangay Bacong, Tulunan North Cotabato and barangay Lampitak, Tampakan South Cotabato. Descriptive method of research using structural and sociolinguistical analysis was utilized to describe and determine the linguistic variety and variation of B’laan language. Findings revealed that B’laan language has two language variety the To Lagad and To Baba. Results further show that linguistic variation on lexical and morphological features of B’laan language in this study is influenced by geographical dimension or the distance of the place where the B’laan people live. B’laan language is unique for its linguistic variety. Research proved that B’laan language is not homogeneous because it has lexical and morphological variation

  2. Varayti at Varyasyon ng Wikang B’laan sa Bacong, Tulunan, Hilagang Cotabato at Lampitak, Tampakan, Timog Cotabato, Philippines

    OpenAIRE

    Radji A. Macatabon; Maria Luz D. Calibayan

    2016-01-01

    The study was conducted to determine the variety and variation of B’laan language in two municipalities. Specifically the study aimed to find out the following: What are the variety of B’laan language? Are there lexical and morphological variations existing in B’laan language by B’laan tribe in Bacong, Tulunan North Cotabato and Lampitak, Tampakan South Cotabato? And What factor influences such linguistic variety and variation of B’laan language? The scope of this study was con...

  3. Vastastikune sõltuvus : Euroopa Venemaa energialõa otsas / Fiona Hill ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Hill, Fiona

    2006-01-01

    Euroopa ja Venemaa energiakaubanduses valitsevast sõltuvusest. Riikide individuaalne haavatavus, Venemaa suhtlemine Euroopa ja teiste üleilmsete turgudega käib vaid nafta ja gaasi abil, mida võib nõrkuseks lugeda, Venemaa gaasimured. Euroopa strateegia peab püüdlema nafta- ja gaasiimpordi jätkuva geograafilise mitmekesistamise poole, et vähendada sõltuvust Venemaast ja Lähis-Idast. Diagrammid

  4. Serbia seisab teelahkmel, reedetuse tunne hinges / Milovan Jaukovic ; tõlk. Dragan Perovic, Marek Laane ja Kadri Liik

    Index Scriptorium Estoniae

    Jaukovic, Milovan

    2006-01-01

    Viimased viisteist aastat on Serbia ainult kaotanud: inimesi, jõukust, mõjuvõimu ja eneseaustust. Serbia tänapäeval, suhted Euroopa Liiduga, sisepoliitiline olukord, suhted Montenegroga, Kosovo küsimus

  5. Tee Kilkennysse läheb läbi... Liivalaia / William Elliott ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Elliott, William

    2005-01-01

    Suurbritannia diplomaat rõhutab vajadust tunda hästi olukorda selles riigis, mida hakatakse rajama või taas üles ehitama. Ta esitab kolm teesi, mida peaks silmas pidama riigi taasülesehitusel. Nn. riskiriikidega diplomaatiliste sidemete säilitamise tähtsusest. Lisa: Rumalaid diplomaatilistest suhetest loobumisi

  6. Plejaadid jõuavad taevasse : transatlantilisus ja laienemine itta / Toomas Hendrik Ilves ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2006-01-01

    Erinevad arusaamad ajaloost lääne- ja idaeurooplaste suhete mõjutajana. Euroopa Liidu vanade ja uute liikmesriikide suhtumisest transatlantilistesse suhetesse. Vene keeles ilmunud ajakirjas: Rossija v globalnoi politike 15. nov. 2006, nr. 6

  7. Francis Fukuyama : edukas lõimumine toetub omakasule, mitte kultuurile / Francis Fukuyama ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Fukuyama, Francis

    2007-01-01

    Autor arutleb Huntingtoni tsivilisatsioonide kokkupõrke teooria üle ja väidab, et identiteetide konflikti aitavad ületada institutsioonidele ja reeglitele rajanev rahvusvaheline kord. Vt. samas: F. Fukuyama lühielulugu

  8. Serbia ja EL : kõigepealt Mladic, siis kõnelused / Chris Patten ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    Patten, Chris

    2007-01-01

    1995. aastal Srebrenica veresauna korraldanud Ratko Mladici vahistamine on üks eeltingimusi Serbiale EL-i stabilisatsioonileppe allakirjutamiseks. Põhjuseks, miks Euroopa Liit püüab loobuda omaenda püstitatud standarditest, on ilmselt Kosovo iseseisvuse küsimus

  9. Toites neid, kes hammustavad toitja kätt / Jean MacKenzie ; tõlk. Marek Laane

    Index Scriptorium Estoniae

    MacKenzie, Jean

    2005-01-01

    Sõja ja rahu kajastamise instituudi Afganistani esinduse direktor räägib oma kogemustest välisabi andmisel riikide meediasektori edendamiseks, Afganistani ajakirjanike koolitusest. Vt. samas: II humanitaarkohalolek

  10. Jeroen Jansen en Nico Laan (eds., Van hof tot overheid. Geschiedenis van literaire instituties in Nederland en Vlaanderen

    Directory of Open Access Journals (Sweden)

    Laurens Ham

    2016-09-01

    Full Text Available Jeroen Jansen en Nico Laan (eds., Van hof tot overheid. Geschiedenis van literaire instituties in Nederland en Vlaanderen (Hilversum: Verloren, 2015, 352 pp., isbn 978 90 8704 544 9.

  11. 76 FR 66032 - Availability of an Environmental Assessment for Field Testing Avian Influenza-Marek's Disease...

    Science.gov (United States)

    2011-10-25

    ... Avian Influenza-Marek's Disease Vaccine, H5 Subtype, Serotype 3, Live Marek's Disease Vector AGENCY...-Marek's Disease Vaccine, H5 Subtype, Serotype 3, Live Marek's Disease Vector. The environmental... notice unless new substantial issues bearing on the effects of this action are brought to our attention...

  12. 76 FR 12932 - Availability of an Environmental Assessment for Field Testing Fowl Laryngotracheitis-Marek's...

    Science.gov (United States)

    2011-03-09

    ... Fowl Laryngotracheitis-Marek's Disease Vaccine, Serotype 3, Live Marek's Disease Vector AGENCY: Animal... Laryngotracheitis-Marek's Disease Vaccine, Serotype 3, Live Marek's Disease Vector. The environmental assessment... testing following the close of the comment period for this notice unless new substantial issues bearing on...

  13. Richard Wollheim 1923-2003 / Marek Volt

    Index Scriptorium Estoniae

    Volt, Marek

    2004-01-01

    Järelehüüe anglo-ameerika filosoofile Richard Wollheimile (5. V 1923-4. XI 2003), kes huvitus maalist ja psühhoanalüüsist ning kuulub XX sajandi analüütilist kunstifilosoofiat enim kujundanud filosoofide hulka. Tema peamised tööd: "Art and Its Objects" (1968), "Painting As an Art" (1987), "On Painting and the Self" (1992). Ilmunud ka raamatus: Volt, Marek. Esteetikast. Tallinn : Sirp, 2006

  14. Seroprevalence of Marek's Disease Virus antibody in some poultry ...

    African Journals Online (AJOL)

    This study reports a survey of Marek's disease virus (MDV) antibody done in 21 selected poultry flocks in Lagos, Ogun and Oyo states of southwestern Nigeria. A total of 315 serum samples were examined using the Enzyme Linked Immunosorbent Assay (ELISA) technique. Marek's disease virus antibody was present in ...

  15. Marek Demjanov : minu roll on inimestele elamusi pakkuda / Marek Demjanov ; interv. Jaana Pikalev

    Index Scriptorium Estoniae

    Demjanov, Marek

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti : Vkus Zhizni, 31. jaan. 2007, lk. 2. Küsimustele karjääri kohta vastab Vene Draamateatri direktor ja restorani Sushi House üks omanikke Marek Demjanov. CV. Kommenteerib Armin Kõomägi

  16. Marek Piestrak loodab, et parim film on veel tegemata / Marek Piestrak ; interv. Urmas Lauri

    Index Scriptorium Estoniae

    Piestrak, Marek

    2008-01-01

    Haapsalu õudusfilmide festivalile HÕFF oli kutsutud poola režissöör Marek Piestrak, kes lavastas Stanislaw Lemi teose järgi Poola ja Tallinnfilmi ühistööna ulmefilmi "Navigaator Prix" (1978). Režissöör meenutab koostööd eestlastega, mida jagus kolmeks filmiks

  17. An account of a recent outbreak of Marek\\'s Disease in Kenya | Kuria ...

    African Journals Online (AJOL)

    Data was collected from a number of flocks following an outbreak of Marek's disease in Thika, Kiambu and Nairobi, in 1997. ... necrotic lesions the suspected contributory causative factors were high field infections pressure, failure to vaccinate, vaccination failure and lack of quarantine and other disease control measures.

  18. Ex uno plures´est e pluribus unum´ini? / Rein Müllerson ; inglise keelest tõlkinud Marek Laane

    Index Scriptorium Estoniae

    Müllerson, Rein, 1944-

    2010-01-01

    Õigusteadlane Rein Müllerson ühiskondliku mitmekesisuse ja homogeensuse arengutest, dissimilatsiooni asendumisest assimilatsiooniga, Ida ja Lääne ühiskondade ühildumisest üleilmastumise protsessis

  19. An MHC class I immune evasion gene of Marek׳s disease virus.

    Science.gov (United States)

    Hearn, Cari; Preeyanon, Likit; Hunt, Henry D; York, Ian A

    2015-01-15

    Marek׳s disease virus (MDV) is a widespread α-herpesvirus of chickens that causes T cell tumors. Acute, but not latent, MDV infection has previously been shown to lead to downregulation of cell-surface MHC class I (Virology 282:198-205 (2001)), but the gene(s) involved have not been identified. Here we demonstrate that an MDV gene, MDV012, is capable of reducing surface expression of MHC class I on chicken cells. Co-expression of an MHC class I-binding peptide targeted to the endoplasmic reticulum (bypassing the requirement for the TAP peptide transporter) partially rescued MHC class I expression in the presence of MDV012, suggesting that MDV012 is a TAP-blocking MHC class I immune evasion protein. This is the first unique non-mammalian MHC class I immune evasion gene identified, and suggests that α-herpesviruses have conserved this function for at least 100 million years. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Kas õpetajad on teie kaudu tööd otsinud? / Natalija Gansen, Merit Laan, Ilmar Kütt... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad: Eesti töötukassa Tallinna ja Harjumaa osakonna teenusekonsultant Natalija Gansen, Eesti töötukassa Viljandimaa osakonna juhataja Merit Laan, Viljandi maavalitsuse haridus- ja sotsiaalosakonna juhataja Ilmar Kütt, CV-Online Estonia OÜ värbamisspetsialist Ivika Born, Lääne-Viru maavalitsuse haridus- ja sotsiaalosakonna vanemspetsialist Tiina Halling ja Valga maavalitsuse haridus- ja kultuuritalituse juhataja Kalle Vister

  1. Farmers' Awareness of Marek's Disease and Biosecurity Practices in ...

    African Journals Online (AJOL)

    Farmers' Awareness of Marek's Disease and Biosecurity Practices in Poultry Production in Selected States of Nigeria. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more information about how ...

  2. Farmers' Awareness of Marek's Disease and Biosecurity Practices in ...

    African Journals Online (AJOL)

    The relationship between Marek's disease (MD) and factors responsible for the continuous enzootic outbreaks in Nigerian poultry farms were investigated. A structured questionnaire was served to test the level of awareness of the poultry farmers in different locations in 2009. The retrieval rate was 68.0% (150/200) from ...

  3. Tähenduslik vorm ja esteetiline emotsioon : formalism analüütilises perspektiivis / Marek Volt

    Index Scriptorium Estoniae

    Volt, Marek

    2004-01-01

    Inglise kunstikriitiku Clive Belli (1881-1964) seisukohtadest raamatus "Kunst", mida peetakse formalismi teoreetiliseks õigustuseks. Ilmunud ka raamatus: Volt, Marek. Esteetikast. Tallinn : Sirp, 2006

  4. Visceral Marek's disease in white-peafowl (Pavo cristatus)

    OpenAIRE

    Blume, G.R.; Cardoso, S.P.; Oliveira, M.L.B.; Matiolli, M.P.; Gómez, S.Y.M.; Reis Júnior, J.L.; Sant'Ana, F.J.F.; Martins, N.R.S.

    2016-01-01

    ABSTRACT Marek's disease (MD) is a lymphoproliferative disorder caused by Gallid herpesvirus 2 (MDV) that infects mainly domestic gallinaceous birds although wild birds may occasionally be affected. The current report describes the anatomopathological and molecular findings of a case of MD in a white-peafowl (Pavo cristatus). The signs included apathy, hyporexia, and diarrhea. Grossly, 0.5 to 1.5cm in diameter, yellow, soft nodules were observed in the skeletal muscle, lung, kidney, air sacs,...

  5. Henriku kroonika pole veel ammendatud / Marek Tamm, Linda Kaljundi ; intervjueerinud Valle-Sten Maiste

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2011-01-01

    Intervjuu Marek Tamme ja Linda Kaljundiga nende poolt toimetatud artiklikogumikust: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  6. Visceral Marek's disease in white-peafowl (Pavo cristatus

    Directory of Open Access Journals (Sweden)

    G.R. Blume

    Full Text Available ABSTRACT Marek's disease (MD is a lymphoproliferative disorder caused by Gallid herpesvirus 2 (MDV that infects mainly domestic gallinaceous birds although wild birds may occasionally be affected. The current report describes the anatomopathological and molecular findings of a case of MD in a white-peafowl (Pavo cristatus. The signs included apathy, hyporexia, and diarrhea. Grossly, 0.5 to 1.5cm in diameter, yellow, soft nodules were observed in the skeletal muscle, lung, kidney, air sacs, small intestine, heart, ovary, ventriculus, and proventriculus. Microscopically, numerous atypical round neoplastic cells were noted. The molecular detection of MDV DNA was implemented to amplify part of the meq gene and products were sequenced for the phylogenetic analysis. Template DNA was obtained from tissues of the affected bird and from blood of all the gallinaceous birds of the Zoo. The expected amplicon for the partial amplification of MDV meq gene was obtained and the amplicons were sequenced. Sequences obtained enabled grouping the strain (accession no. KT768121 with MDV serotype 1 strains from the GenBank. Based on the anatomopathological and molecular findings, the diagnosis of MD in a white-peafowl was reached, and to the authors' knowledge, no previous report regarding MD was published in Pavo cristatus.

  7. La recriture 1 des mythes bibliques dans les recits de Marek Halter ...

    African Journals Online (AJOL)

    . Aujourd'hui encore les personnages de la Bible deviennent des personnages de romans. Avec le Brésilien Paulo Coelho et le Polonais naturalisé Français, Marek Halter réinterprètent la Bible à l'aube du XXIè siècle dans l'espace littéraire.

  8. Ajalool on ajaloolaste nägu / Jean-Claude Schmitt ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Schmitt, Jean-Claude

    2004-01-01

    Intervjuu ajaloolase Jean-Claude Schmittiga. Ilm. ka: Keha, pilt ja unenägu : intervjuu Jean-Claude Scmittiga // Schmitt, Jean-Claude. Püha hurdakoer : Guinefort - lasteravija 13. sajandist. - Tallinn, 2000. - Lk. 296-305 ; Kuidas kirjutatakse ajalugu? // Tamm, Marek. Kuidas kirjutatakse ajalugu? - Tallinn, 2007. - 161-177

  9. AN MHC class I immune evasion gene of Marek's disease virus

    Science.gov (United States)

    Marek's disease virus (MDV) is a widespread a-herpesvirus of chickens that causes T cell tumors. Acute, but not latent, MDV infection has previously been shown to lead to downregulation of cell-surface MHC class I (Virology 282:198–205 (2001)), but the gene(s) involved have not been identified. Here...

  10. Diagnosis of Marek's Disease From a Japanese Quail (Coturnix Japonica) Using Paraffin-embedded Liver

    Science.gov (United States)

    A single paraffin-embedded liver section was submitted from a research flock of Japanese quail that had revealed focal infiltrations of immature lymphocytes within multiple visceral organs. Tumor cells were characterized as T-cells positive for Marek's disease virus (MDV) pp38 antigen by IHC dual st...

  11. Keda ja kuidas administreerida - keskkonda või inimest? / Heiki Kranich, Marek Strandberg

    Index Scriptorium Estoniae

    Kranich, Heiki, 1961-

    2002-01-01

    Keskkonnaminister Heiki Kranichi ja ökofilosoof Marek Strandbergi väitlus looduskaitsjate ühisel nõukojal Leigo talus looduskeskkonna pakutavatest võimalustest, energeetika ja keskkonnakaitse küsimustest, Greenpeace'i aktsioonidest Tallinnas, säästvast arengust, keskkonda puudutavast seadusandlusest. Autor: Reformierakond

  12. Industry-Wide Surveillance of Marek's Disease Virus on Commercial Poultry Farms.

    Science.gov (United States)

    Kennedy, David A; Cairns, Christopher; Jones, Matthew J; Bell, Andrew S; Salathé, Rahel M; Baigent, Susan J; Nair, Venugopal K; Dunn, Patricia A; Read, Andrew F

    2017-06-01

    Marek's disease virus is a herpesvirus of chickens that costs the worldwide poultry industry more than US$1 billion annually. Two generations of Marek's disease vaccines have shown reduced efficacy over the last half century due to evolution of the virus. Understanding where the virus is present may give insight into whether continued reductions in efficacy are likely. We conducted a 3-yr surveillance study to assess the prevalence of Marek's disease virus on commercial poultry farms, determine the effect of various factors on virus prevalence, and document virus dynamics in broiler chicken houses over short (weeks) and long (years) timescales. We extracted DNA from dust samples collected from commercial chicken and egg production facilities in Pennsylvania, USA. Quantitative PCR was used to assess wild-type virus detectability and concentration. Using data from 1018 dust samples with Bayesian generalized linear mixed effects models, we determined the factors that correlated with virus prevalence across farms. Maximum likelihood and autocorrelation function estimation on 3727 additional dust samples were used to document and characterize virus concentrations within houses over time. Overall, wild-type virus was detectable at least once on 36 of 104 farms at rates that varied substantially between farms. Virus was detected in one of three broiler-breeder operations (companies), four of five broiler operations, and three of five egg layer operations. Marek's disease virus detectability differed by production type, bird age, day of the year, operation (company), farm, house, flock, and sample. Operation (company) was the most important factor, accounting for between 12% and 63.4% of the variation in virus detectability. Within individual houses, virus concentration often dropped below detectable levels and reemerged later. These data characterize Marek's disease virus dynamics, which are potentially important to the evolution of the virus.

  13. Kultuuri ei saa uurida vaakumis / Rebekka Lotman, Daniele Monticelli, Marek Tamm, Rein Raud ; intervjueerinud Valle-Sten Maiste

    Index Scriptorium Estoniae

    Lotman, Rebekka, 1978-

    2016-01-01

    100 raamatuni jõudnud Tallinna Ülikooli Kirjastus on püüdnud Eestis juurutada teaduskirjastamise rahvusvahelisi standardeid. Vestlusringis Rebekka Lotman, Daniele Monticelli, Marek Tamm ja Rein Raud

  14. Students' Entrepreneurship in Post-Socialist Countries [sci. ed. Jarosław Korpysa, Marek Kunasz

    OpenAIRE

    Zaharia, Rodica Milena

    2009-01-01

    Scientific editors of the collective monograph Dr. Tomasz Bernat and Dr. Marek Kunasz present the result of the work which took many years to complete – a book “Studentų antreprenerystė posocialistinėse šalyse” [Students’ Entrepreneurship in Post-Socialist Countries], containing comprehensive scientific studies on the spectre of entrepreneurship skills of students in six post-soviet countries – Poland, Latvia, Lithuania, Hungary, the Ukraine and Russia. The data were obtained through survey o...

  15. Recent trends in diagnosis and control of Marek's disease (MD) in poultry.

    Science.gov (United States)

    Singh, Shambhu Dayal; Barathidasan, Rajamani; Kumar, Asok; Deb, Rajib; Verma, Amit Kumar; Dhama, Kuldeep

    2012-10-15

    Marek's Disease (MD), caused by Marek's Disease Virus (MDV) is a highly contagious oncogenic and neuropathic disease of chickens responsible for great economic losses to the poultry industry all around the world and characterized by development of CD4+T cell lymphomas as well as infiltration of nerves and visceral organs by lymphocytes. MD is one of the most common lymphoproliferative diseases of chickens which cause mononuclear cell infiltration in one or more of the following tissues: peripheral nerves, gonads, lymphoid organs, iris, muscle, skin and other visceral organs resulting into development of tumours in visceral organs, paralysis of legs, wings and neck, grey eye (iris) or irregular pupil, vision impairment, blindness, skin lesions and immunosuppression, all of which can be accompanied by non-specific signs such as anorexia, weight loss and poor performance. Today there are evolving highly pathogenic isolates of MDV around the world capable of overwhelming the protection from currently employed vaccines. Thus MD poses a big challenge to the welfare and wellbeing of the poultry with increased condemnation of carcass, loss of productivity and quality products, leading to huge economic losses. It is also an immunosuppressive disease and causes increased susceptibility to other infections. The present review discusses in brief about the Marek's disease, its etiology, conventional and advance tools and techniques being used for its diagnosis, prevention and control strategies in poultry.

  16. Sissejuhatus sõnavõlur Tolkieni juurde / Neeme Korv

    Index Scriptorium Estoniae

    Korv, Neeme, 1974-

    2003-01-01

    Carpenter, Humphrey. J. R. R. Tolkien : elulugu / inglise keelest tõlkinud Tiina Randus.Tallinn : Tänapäev, 2002 ; Day, David. Tolkieni entsüklopeedia / inglise keelest tõlkinud Marek Laane. Tallinn : Varrak, 2002

  17. Differences in CD8 alpha alpha and cecal microbiome community during proliferation and late cytolytic phases of Marek's disease virus (MDV) infection are associated with genetic resistance to Marek's disease

    Science.gov (United States)

    There is growing awareness that microbes in the gut play an important role in the health and disease response of the host. In this study, using chicken and Marek's disease virus, an economically important pathogen, we correlate changes in immune cells with gut microbes and their function. We find th...

  18. LAAnAAA

    Indian Academy of Sciences (India)

    04 Glial Cens: The Other Cells of the Nervous System. aCIIIICl. Introduction. 94. An Introduction to Glial Cells. V Rajaraman. Wireless Telegraphic. Communication. Guglielmo Marconi. 53 at Marconi point on Cape Cod, USA. Medha S Raiadhyaksha and Yasmin Khan. GENERAL ARTICLES. 11 Splitting of Comets.

  19. Titration of Marek's disease cell-associated vaccine virus (CVI 988) of reconstituted vaccine and vaccine ampoules from dutch hatcheries

    NARCIS (Netherlands)

    Landman, W.J.M.; Pritz-Verschuren, S.B.E.

    2003-01-01

    SUMMARY. Thirty-one outbreaks of Marek¿s disease (MD) were reported in the Netherlands and retrospectively analyzed. The outbreaks occurred mostly in vaccinated commercial layer and a few breeder flocks of several breeds; however, the cause of the outbreaks could not be stablished. Therefore, in a

  20. Development of a primer-probe energy transfer based real-time PCR for detection of Marek's disease virus

    DEFF Research Database (Denmark)

    Barfoed, Annette Malene; Østergaard, E.; Frandsen, P.L.

    2010-01-01

    A real-time PCR assay, which enables simultaneous detection and differentiation of all three serotypes of Marek's disease virus, without the need for post-PCR sequencing, has been developed. The assay is based on the primer-probe energy transfer real-time PCR, which has a relatively high tolerance...

  1. Marek's disease vaccines: a solution for today but a worry for tomorrow?

    Science.gov (United States)

    Gimeno, Isabel M

    2008-07-18

    Marek's disease (MD) is a lymphoproliferative disease of chickens that, in the absence of control measures, is capable of causing devastating losses in commercial poultry flocks. MD has been successfully controlled by vaccination since 1968. However, vaccine efficacy has decreased concomitantly with the increase in virulence of Marek's disease virus (MDV). The constant evolution of MDV has forced the development of new vaccines or vaccine strategies that control the more virulent emergent strains. However, this race between the introduction of new vaccines and the evolution of MDV represents a major threat for the poultry industry. In addition to vaccination, other factors might have contributed to the evolution of MDV (intensive methods of chicken production, early exposure of the chickens to MDV and administration of vaccines at very low doses). From all the possible factors influencing MDV evolution, the effect of vaccination has received the greatest attention. MD vaccines protect with great efficacy against the development of the disease but they do not prevent infection or transmission. Sterilizing immunity could be a solution to stop the evolution of the virus but it has been proven to be extremely difficult, if at all possible, to obtain with MDV or with other herpesviruses. Other solutions to improve vaccine-induced protection are discussed in this paper.

  2. The effectiveness of mass vaccination on Marek's disease virus (MDV) outbreaks and detection within a broiler barn: A modeling study ?

    OpenAIRE

    Atkins, Katherine E.; Read, Andrew F.; Walkden-Brown, Stephen W.; Savill, Nicholas J.; Woolhouse, Mark E.J.

    2013-01-01

    Marek's disease virus (MDV), a poultry pathogen, has been increasing in virulence since the mid twentieth century. Since multiple vaccines have been developed and widely implemented, losses due to MDV have decreased. However, vaccine failure has occurred in the past and vaccine breakthroughs remain a problem. Failure of disease control with current vaccines would have significant economic and welfare consequences. Nevertheless, the epidemiology of the disease during a farm outbreak is not wel...

  3. Marek Biesiada

    Indian Academy of Sciences (India)

    This expectation is consistent with baryonic matter budget in clusters, especially with the so called missing baryons problem. The cosmological microlensing hypothesis although demands an unusual setting. (the transient itself being unusual as well) which is more parsimonious than already proposed models of explosion ...

  4. Marek Biesiada

    Indian Academy of Sciences (India)

    Abstract. In this paper, we consider the mysterious optical transient. SCP 06F6 displaying a symmetric light curve with a (half-time) duration of about 100 days. The projected location of the event falls close to the center of the galaxy cluster CL 1432.5 + 332.8 lying at the redshift z = 1.112. Guided by suggestive symmetry of ...

  5. Detection and differentiation of CVI988 (Rispens vaccine) from other serotype 1 Marek's disease viruses.

    Science.gov (United States)

    Gimeno, Isabel M; Dunn, John R; Cortes, Aneg L; El-Gohary, Abd El-Galil; Silva, Robert F

    2014-06-01

    The serotype 1 Marek's disease virus (MDV) is the causative agent for Marek's disease (MD), a lymphoproliferative disease of chickens of great concern to the poultry industry. CVI988 (Rispens vaccine), an attenuated serotype 1 MDV, is currently the most efficacious commercially available vaccine for preventing MD. However, it is difficult to detect and differentiate CVI988 when other serotype 1 MDVs are present. To facilitate the detection of CVI988, we developed two sets of primers for a mismatch amplification mutation assay (MAMA) PCR that targeted the single nulceotide polymorphism associated with the H19 epitope of the phosphorylated protein 38 gene. The PCR was very specific. One primer set (oncogenic primers) amplified DNA from 15 different serotype 1 MDVs except CVI988. The other primer set (CVI988 primers) amplified DNA from CVI988 but not from any of the other 15 serotype 1 MDVs. A real-time PCR assay was developed using MAMA primers, and specificity and sensitivity was evaluated in vitro and in vivo. Mixtures of plasmids (CVI988 plasmid and oncogenic plasmid) at various concentrations were used to evaluate the sensitivity/specificity of MAMA primers in vitro. Both primer setswere able to amplify as little as one copy of their respective plasmid. Oncogenic primers were highly specific and only amplified CVI988 plasmid when the concentration of oncogenic plasmid was very low (1 X 10(1)) and CVI988 plasmid was very high (1 X 10(6)). Specificity of CVI988 primers was not as high because they could amplify oncogenic plasmids when the concentration of CVI988 plasmid was 1 x 10(3) and the concentration of oncogenic 1 x 10(2). Validation of MAMA primers in in vivo samples demonstrated that oncogenic primers can be used for both early diagnosis of MD in feather pulp (FP) samples collected at 3 wk of age and confirmation of MD diagnosis in tumors. CVI988 primers could be used to monitor CVI988 vaccination in samples with a low load of oncogenic MDV DNA (latently

  6. Route of challenge is critical in determining the clinical outcome of infection with a very virulent oncogenic herpesvirus, Marek's disease virus.

    OpenAIRE

    Butter , Colin; Staines , Karen; Baaten , Bas; Smith , Lorraine; Davison , Fred

    2007-01-01

    Abstract Susceptible (Line 7) and resistant (Line 6) white leghorn chickens were infected with a very virulent Marek?s Disease Virus, RB1B, by either the intra-abdominal or intra-tracheal routes. Birds infected by the intra-tracheal route had earlier, higher or more sustained blood, spleen and lung viral loads, than those infected by the intra-peritoneal route. Line 7 birds had higher viral loads than Line 6 birds infected by the same route. Clinical outcomes reflected these ...

  7. Evaluation of the Protection Efficacy of a Serotype 1 Marek's Disease Virus-Vectored Bivalent Vaccine Against Infectious Laryngotracheitis and Marek's Disease.

    Science.gov (United States)

    Gimeno, Isabel M; Cortes, Aneg L; Faiz, Nik M; Hernandez-Ortiz, Byron A; Guy, James S; Hunt, Henry D; Silva, Robert F

    2015-06-01

    Laryngotracheitis (LT) is a highly contagious respiratory disease of chickens that produces significant economic losses to the poultry industry. Traditionally, LT has been controlled by administration of modified live vaccines. In recent years, the use of recombinant DNA-derived vaccines using turkey herpesvirus (HVT) and fowlpox virus has expanded, as they protect not only against the vector used but also against LT. However, HVT-based vaccines confer limited protection against challenge, with emergent very virulent plus Marek's disease virus (vv+MDV). Serotype 1 vaccines have been proven to be the most efficient against vv+MDV. In particular, deletion of oncogene MEQ from the oncogenic vvMDV strain Md5 (BACδMEQ) resulted in a very efficient vaccine against vv+MDV. In this work, we have developed two recombinant vaccines against MD and LT by using BACδMEQ as a vector that carries either the LT virus (LTV) gene glycoprotein B (gB; BACΔMEQ-gB) or LTV gene glycoprotein J (gJ; BACδMEQ-gJ). We have evaluated the protection that these recombinant vaccines confer against MD and LT challenge when administered alone or in combination. Our results demonstrated that both bivalent vaccines (BACΔMEQ-gB and BACδMEQ-gJ) replicated in chickens and were safe to use in commercial meat-type chickens bearing maternal antibodies against MDV. BACΔMEQ-gB protected as well as a commercial recombinant (r)HVT-LT vaccine against challenge with LTV. However, BACδMEQ-gJ did not protect adequately against LT challenge or increase protection conferred by BACΔMEQ-gB when administered in combination. On the other hand, both BACΔMEQ-gB and BACδMEQ-gJ, administered alone or in combination, protected better against an early challenge with vv+MDV strain 648A than commercial strains of rHVT-LT or CVI988. Our results open a new avenue in the development of recombinant vaccines by using serotype 1 MDV as vectors.

  8. Telomerase Activity in Chicken EmbryoFibroblast Cell Cultures Infected withMarek's Disease Virus

    Directory of Open Access Journals (Sweden)

    Gregory A. Tannock

    2010-07-01

    Full Text Available Background:Telomerase is a ribonucleoprotein, which adds telomeric repeats onto the 3’end of existing telomers at the end of chromosomes ineukaryotes. One hypothesis states that telomere length may function as a mitoticclock, therefore expression of telomerase activity in cancer cells may be a necessary and essential step for tumor development and progression.Methods:The detectability of telomerase activity in chicken embryofibroblast (CEF cells infected with different passages of Marek's disease virus(MDV was tested with the TRAPEZE® telomerase detection kit at passages14 (P14, P80/1 and P120 for the Woodland strain, and passage 9 (P9 for theMPF57 strain. Results:The results showed increased telomerase activity in MDV Woodlands strain at P14 and MPF57 strain at P9. Conclusion:Our results suggest that MDV-transformed cells at low passage are a suitable system for the study of telomerases in tumor developmentand for testing telomerase-inhibiting drugs.

  9. Detection of Marek's disease virus DNA in Japanese quail susceptible to atherosclerosis

    International Nuclear Information System (INIS)

    Pyrzak, R.; Shih, J.C.H.

    1986-01-01

    Marek's disease virus (MDV) was demonstrated as an etiological agent which causes atherosclerosis in the chicken. Since herpes viruses are ubiquitous, incidences of viral atherogenesis in humans and other animals were speculated. In this laboratory, the atherosclerosis susceptible (SUS) and resistant (RES) Japanese quail were developed as the animal model for atherosclerosis research. The susceptibility of the animal might be due to an infection of MDV or a related quail herpes virus (QHV). An initial attempt to isolate viruses from quail and an agar gel precipitin test for MDC were not positive. A DNA hybridization technique was used to determine whether the MDC-DNA existed in the quail cell. The gene library of MDV EcoRl DNA fragments was used to prepare the DNA probe, labeled with [ 32 P] by nick translation. Dot hybridizations were carried out by mixing the MDV-DNA probe with DNAs isolated from quail tissues. A high stringent condition was used. From this experiment it was found that the tissues from the SUS quail were hybridization positive, but most of them from RES quail were negative. When aortas were compared, the severe atherosclerotic had a strong hybridization (3-4 cop. of genome/cell) whereas the others hybridized moderately (1 cop./cell). It was concluded that genes from MDV or a QHV indeed existed in Japanese quail

  10. Comparison of different sites in recombinant Marek's disease virus for the expression of green fluorescent protein.

    Science.gov (United States)

    Liu, Yongzhen; Li, Kai; Cui, Hongyu; Gao, Li; Liu, Changjun; Zhang, Yanping; Gao, Yulong; Wang, Xiaomei

    2017-05-02

    Marek's disease virus (MDV) is a preferred vector for recombinant vaccine construction, and insertion site is the main factor influencing foreign gene expression and vaccine efficacy. In this study, recombinant MDVs inserted with the enhanced green fluorescent protein (eGFP) gene at different sites in its genome were generated from overlapping fosmid DNAs and the eGFP expression was compared. The results showed that the eGFP expression levels from the sites in the unique long (UL) region (within UL41, between UL45 and UL46, and between UL55 and LORF10) were comparable, which were significantly higher than those from the sites in the unique short (US) region (US2 and US10), and the eGFP expression level from US2 was significantly higher than that from US10. The identification and comparison of the insertion sites in MDV genome could help elevate the protection efficacy of the recombinant MDVs expressing desired antigens. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. EPIDEMIOLOGICAL STUDY OF MAREKE'S DISEASE IN COMMERCIAL LAYER FLOCKS IN DISTRICT TOBA TEK SING

    Directory of Open Access Journals (Sweden)

    A.U. Haq, M. Siddique1 and Z. lqbal

    2001-09-01

    Full Text Available A study was conducted to assess the prevalence and various risk indicators of Marek's disease (MD in commercial layer flocks. A total of.207 layer flocks were studied around Gojra, district Toba Tek Singh from July 1998 to June 1999. Data were collected through cross-sectional epidemiological methods regarding their demography, management practices, prophylactic procedures and concurrent diseases. Prevalence attack rate of Mb in this population was 20.77% (43/207. A mortality rate ranging from 5.40 to 11.60 per cent was recorded. The maximum prevalence was observed in birds of 13 to 30 weeks of age. Eleven out of 12 categorial variables had significant relationship with flock MD status. The most important risk factor of the disease was early exposure of Immunosuppressive diseases like Gumboro, chicken infectious anaemia and coccidiosis, etc. (P<0.01. Other factors were non restricted movement of visitors (P<0.01, poor and un-isolated broodjng of chickens (P<0.01, presence of farm animals and pet birds (P<0,01 0 It was also observed that the disease prevalence was quite high on farms owned by laymen in comparison with those managed by educated persons (P<0.0 1.

  12. Pathogenicity of a Very Virulent Strain of Marek's Disease Herpesvirus Cloned as Infectious Bacterial Artificial Chromosomes

    Directory of Open Access Journals (Sweden)

    Lorraine P. Smith

    2011-01-01

    Full Text Available Bacterial artificial chromosome (BAC vectors containing the full-length genomes of several herpesviruses have been used widely as tools to enable functional studies of viral genes. Marek's disease viruses (MDVs are highly oncogenic alphaherpesviruses that induce rapid-onset T-cell lymphomas in chickens. Oncogenic strains of MDV reconstituted from BAC clones have been used to examine the role of viral genes in inducing tumours. Past studies have demonstrated continuous increase in virulence of MDV strains. We have previously reported on the UK isolate C12/130 that showed increased virulence features including lymphoid organ atrophy and enhanced tropism for the central nervous system. Here we report the construction of the BAC clones (pC12/130 of this strain. Chickens were infected with viruses reconstituted from the pC12/130 clones along with the wild-type virus for the comparison of the pathogenic properties. Our studies show that BAC-derived viruses induced disease similar to the wild-type virus, though there were differences in the levels of pathogenicity between individual viruses. Generation of BAC clones that differ in the potential to induce cytolytic disease provide the opportunity to identify the molecular determinants of increased virulence by direct sequence analysis as well as by using reverse genetics approaches on the infectious BAC clones.

  13. Current status of Marek's disease in the United States and worldwide based on a questionnaire survey.

    Science.gov (United States)

    Dunn, John R; Gimeno, Isabel M

    2013-06-01

    A questionnaire was widely distributed in 2011 to estimate the global prevalence of Marek's disease (MD) and gain a better understanding of current control strategies and future concerns. A total of 112 questionnaires were returned representing 116 countries from sources including national branch secretaries of the World Veterinary Poultry Association, vaccine, breeder, and production companies, as well as MD researchers from various backgrounds. Each country listed on a questionnaire was recorded as an individual entry, and on average there were 2.0 entries per country (median 1; range 1-13). All flock types were listed as having increased MD incidence during the last 10 yr in close to 50% of countries by at least one respondent, with the majority of these countries located within French-speaking Africa, Eastern Europe, East Asia, and South America. Only 18 countries (16%) indicated increasing MD incidence was likely due to higher virulent strains, while the presence of other immunosuppressive diseases was a more common explanation. Increased use of CVI988/Rispens was cited as the most likely reason for decreasing MD incidence in 49 countries (42%). In the United States, MD incidence has continued to decrease during the last 10 yr, reaching a record low in 2007 (0.0008%) as measured by leukosis condemnation rates in broilers at slaughter. However, a recent increase of leukosis condemnations in North Carolina and Pennsylvania needs to be closely monitored.

  14. Toetuseta jäämine šokeeris mainekat kultuuriajakirja / Ott Raun, Laine Jänes ; interv. Rebekka Lotman ; komment. Marek Tamm

    Index Scriptorium Estoniae

    Raun, Ott, 1940-

    2009-01-01

    Eesti Kultuurkapitalinõukogu otsusel jääb ajalookultuuri ajakiri "Tuna" alates 2009. aastast püsitoetusest ilma. Sellega seotud küsimustele vastavad "Tuna" peatoimetaja Ott Raun ja Eesti Kultuurkapitali nõukogu esimees Laine Jänes, kommenteerinud ajaloolane Marek Tamm

  15. Association of Marek's Disease induced immunosuppression with activation of a novel regulatory T cells in chickens.

    Directory of Open Access Journals (Sweden)

    Angila Gurung

    2017-12-01

    Full Text Available Marek's Disease Virus (MDV is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and potentially due to activation of regulatory T (Treg-cells. Furthermore, immunosuppression also occurs during the transformation phase of the disease; however, it is still unknown how the disease can suppress immune response prior or after lymphoma formation. Here, we demonstrated that chicken TGF-beta+ Treg cells are found in different lymphoid tissues, with the highest levels found in the gut-associated lymphoid tissue (cecal tonsil: CT, fostering an immune-privileged microenvironment exerted by TGF-beta. Surprisingly, significantly higher frequencies of TGF-beta+ Treg cells are found in the spleens of MDV-susceptible chicken lines compared to the resistant line, suggesting an association between TGF-beta+ Treg cells and host susceptibility to lymphoma formation. Experimental infection with a virulent MDV elevated the levels of TGF-beta+ Treg cells in the lungs as early as 4 days post infection, and during the transformation phase of the disease in the spleens. In contrast to TGF-beta+ Treg cells, the levels of CD4+CD25+ T cells remained unchanged during the infection and transformation phase of the disease. Furthermore, our results demonstrate that the induction of TGF-beta+ Treg cells is associated with pathogenesis of the disease, as the vaccine strain of MDV did not induce TGF-beta+ Treg cells. Similar to human haematopoietic malignant cells, MDV-induced lymphoma cells expressed high levels of TGF-beta but very low levels of TGF-beta receptor I and II genes. The results confirm that COX-2/ PGE2 pathway is involved in immunosuppression induced by MDV-lymphoma cells. Taken together, our results revealed a novel TGF-beta+ Treg subset in chickens that is activated during MDV infection and tumour

  16. Marek's disease virus infection induces widespread differential chromatin marks in inbred chicken lines.

    Science.gov (United States)

    Mitra, Apratim; Luo, Juan; Zhang, Huanming; Cui, Kairong; Zhao, Keji; Song, Jiuzhou

    2012-10-16

    Marek's disease (MD) is a neoplastic disease in chickens caused by the MD virus (MDV). Successful vaccine development against MD has resulted in increased virulence of MDV and the understanding of genetic resistance to the disease is, therefore, crucial to long-term control strategies. Also, epigenetic factors are believed to be one of the major determinants of disease response. Here, we carried out comprehensive analyses of the epigenetic landscape induced by MDV, utilizing genome-wide histone H3 lysine 4 and lysine 27 trimethylation maps from chicken lines with varying resistance to MD. Differential chromatin marks were observed on genes previously implicated in the disease such as MX1 and CTLA-4 and also on genes reported in other cancers including IGF2BP1 and GAL. We detected bivalent domains on immune-related transcriptional regulators BCL6, CITED2 and EGR1, which underwent dynamic changes in both lines as a result of MDV infection. In addition, putative roles for GAL in the mechanism of MD progression were revealed. Our results confirm the presence of widespread epigenetic differences induced by MD in chicken lines with different levels of genetic resistance. A majority of observed epigenetic changes were indicative of increased levels of viral infection in the susceptible line symptomatic of lowered immunocompetence in these birds caused by early cytolytic infection. The GAL system that has known anti-proliferative effects in other cancers is also revealed to be potentially involved in MD progression. Our study provides further insight into the mechanisms of MD progression while revealing a complex landscape of epigenetic regulatory mechanisms that varies depending on host factors.

  17. Depression of Vaccinal Immunity to Marek's Disease by Infection with Chicken Infectious Anemia Virus.

    Science.gov (United States)

    Zhang, Yankun; Cui, Ning; Han, Ni; Wu, Jiayan; Cui, Zhizhong; Su, Shuai

    2017-01-01

    Marek's disease (MD) has been occurring with increasing frequency in chickens in recent years. To our knowledge, however, there has been no report of the very virulent plus (vv+) MD virus (MDV) field isolate in China. Studies have shown that dual infection with immunosuppressive viruses such as chicken infectious anemia virus (CIAV) occurs frequently in chickens developing MD. In this study, we performed a designed set of in vivo experiments, which comprised five different groups of chickens, including the group of CVI988/Rispens-vaccinated chickens, the groups of CVI988/Rispens-vaccinated chickens infected with MDV or CIAV or both viruses (MDV and CIAV), and the group of MDV-challenged chickens. The effects of CIAV dual infection on the immunization of commercial MDV vaccine CVI988/Rispens were evaluated. The results show that infection of the SD15 strain of CIAV significantly reduced the weight and antibody titers to avian influenza virus (AIV)/Newcastle disease virus (NDV) inactivated vaccines of chickens immunized with the CVI988/Rispens, and resulted in the atrophy of thymus/bursa and the enlargement of spleen. The CVI988/Rispens vaccination conferred good immune protection for chickens challenged with 2000 PFU of the GX0101 strain of MDV. However, dual infection with SD15 significantly reduced the body weight, antibody titers induced by AIV/NDV inactivated vaccines and protective index of CVI988/Rispens, and resulted in the aggravation of the immunosuppression, mortality, and viremia of GX0101 in CVI988/Rispens-immunized/GX0101-challenged chickens. Overall, CIAV infection significantly reduced the protective effects of the CVI988/Rispens vaccine against MDV, implying that concurrent infection with CIAV may be a major contributor in the frequent attacks of MD in China in recent years.

  18. Mutations within ICP4 acquired during in vitro attenuation do not alter virulence of recombinant Marek's disease viruses in vivo

    Directory of Open Access Journals (Sweden)

    Evin Hildebrandt

    2015-12-01

    Full Text Available Marek's disease (MD is a T-cell lymphoma of chickens caused by the oncogenic Marek's disease virus (MDV. MD is primarily controlled by live-attenuated vaccines generated by repeated in vitro serial passage. Previous efforts to characterize attenuated MDVs identified numerous mutations, particularly a convergence of high-frequency mutations around amino acids 60–63 within ICP4 (RS1, therefore, ICP4 was considered a candidate gene deserving further characterization. Recombinant MDVs were generated containing a single Q63H mutation or double Q63H + S1630P mutations. Despite the repetitive nature of mutations within ICP4, neither recombinant virus decreased virulence, although one mutant reduced in vivo replication and failed to transmit horizontally. Our results indicate that these mutations are insufficient to reduce disease incidence in infected birds, and suggest that variants in ICP4 do not directly alter virulence, but rather may enhance MDV replication rates in vitro, offering an explanation for the widespread occurrence of ICP4 mutations in a variety of attenuated herpesviruses.

  19. [Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia. Hrsg. von Marek Tamm, Linda Kaljundi, Carsten Selch Jensen] / Volker Honemann

    Index Scriptorium Estoniae

    Honemann, Volker, 1943-

    2013-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia. Hrsg. von Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Verlag Ashgate. Farnham, 2011

  20. Book Review: Michael Baun and Dan Marek (eds. The New Member States and the European Union. Foreign Policy and Europeanization

    Directory of Open Access Journals (Sweden)

    Adelin Dumitru

    2014-09-01

    Full Text Available A radical decision at the time, the 2004 enlargement constituted a critical juncture for the Central and Eastern European Countries. Although a great deal of literature has been written in regard to other aspects of Europeanization, the effects of EU membership on the foreign policy of the new member states have been rarely discussed. This is what the volume coordinated by Michael Baun and Dan Marek seeks to accomplish, namely to fill a gap in the European Studies with a series of articles explaining the more or less significant institutional and behavioural changes which occurred at the level of the new member states’ political elites. Focusing on three main domains in which Europeanization purportedly occurred, namely national preferences and interests, institutions and procedures, foreign policy strategies and actions, the studies gathered in this volume provide a useful overview of the effects of EU membership on what was traditionally known as “foreign policy”.

  1. The use of serotype 1-and serotype 3-specific polymerase chain reaction for the detection of Marek's disease virus in chickens

    DEFF Research Database (Denmark)

    Handberg, Kurt; Nielsen, Ole L.; Jørgensen, Poul Henrik

    2001-01-01

    was applied to samples collected from four commercial table egg layer flocks of young stock or pullets vaccinated with either serotype 1 (CVI988) or serotype 3 (HVT) vaccine. These flocks had various clinical signs of Marek's disease. MDV-1 was detected in buffy-coat cells, spleen, liver, skin, feather tips...... and ovaries. The detection of MDV in feather tips appeared to be as sensitive as co-cultivation of buffy-coat cells, although an inhibiting factor was observed in extracts from feather tips of non-white chickens. This inhibition could be overcome in most extracts by applying a bovine serum albumen...

  2. In ovo evaluation of FloraMax®-B11 on Marek´s disease HVT vaccine protective efficacy, hatchability, microbiota composition, morphometric analysis, and Salmonella Enteritidis infection in broiler chickens

    Science.gov (United States)

    Four experiments were conducted to evaluate the effect of in ovo administration of FloraMax®-B11 (FM) on Marek´s disease (MD) herpesvirus of turkeys (HVT) vaccine protective efficacy, hatchability, microbiota composition, morphometric analysis and Salmonella enteritidis (SE) infection in chickens. I...

  3. Evaluation of Factors Influencing Efficacy of Vaccine Strain CVI988 Against Marek's Disease in Meat-Type Chickens.

    Science.gov (United States)

    Gimeno, Isabel M; Cortes, Aneg L; Faiz, Nik M; Barbosa, Taylor; Villalobos, Tarsicio

    2015-09-01

    Marek's disease (MD) strain CVI988 is the most-protective commercially available vaccine against very virulent plus (vv+) Marek's disease virus (MDV). However, its use in meat-type chickens has been controversial. While several countries have been using CVI988 for more than 40 yr, others do not authorize its use or it is restricted mainly to layers. The use of CVI988 in meat-type chickens will be necessary in the future in areas where other vaccine protocols fail. The objective of this study was to evaluate factors (vaccine dose, vaccine origin, chicken genetics, age and route of vaccination, and combination with other MD vaccines) influencing the efficacy of CVI988 against MD in meat-type chickens. Three animal experiments were conducted in which various vaccine protocols using CVI988 were tested for their protection against challenge with vv+ strain 648A by contact at day of age. Experiments 1 and 2 were to compare the efficacy of CVI988 vaccines from three different origins (CVI988-A, CVI988-B, and CVI988-C) and evaluate the effect of vaccine dose and chicken genetics. Experiment 3 was to evaluate the effect of adding CVI988 vaccine to various vaccine protocols using other MD vaccines of serotypes 2 (SB-1) and 3 (rHVT). Our results show that, regardless of the origin of the vaccine, protection against early challenge with 648A was good when vaccines were administered at a high dose (>3000 plaque-forming units [PFU]). Differences among vaccines, however, were detected even when using a high dose in experiment 2 (vaccine CVI988-B conferred higher protection than did CVI988-C) but not in Experiment 1 (CVI988-B was compared to CVI988-A). The use of a fixed low dose (2000 PFU) of vaccine resulted in reduction in protection, and such reduction was more remarkable when using CV1988-A. No statistically significant differences were found when we compared the efficacy of CVI988 in two different genetic lines of broiler chickens (G1 and G2). Vaccination protocols that

  4. Morphology of immune organs after very virulent plus strain of Marek's disease virus infection in vaccinated hens.

    Science.gov (United States)

    Madej, J P; Woźniakowski, G; Gaweł, A

    2016-01-01

    Marek's disease (MD) outbreaks in poultry flocks may be associated with overriding of vaccine immune protection by very virulent (vvMDV) or very virulent plus (vv+MDV) strains. This paper presents the study on lymphoid organ morphology in the latent phase of MD caused by vv+MDV which break post-vaccinal protection in hens. We also immunohistochemically examined B and T populations as well as B/T and CD4+/CD8+ ratio of lymphocytes in lymphatic organs and, as a background, in MD lymphomas from non-lymphatic organs. The number of antigen expressed cells was evaluated as a percentage of positive cells in the one power field. Organ samples were collected from 24 dead reproductive hens (Ross 308 line) in age between 35-56 weeks, infected with vv+MDV. The hens originated from farms with MD outbreaks, despite earlier routine vaccination with CVI988/Rispens + HVT. The control organ samples originated from 15 clinically healthy hens at the same age and line, subjected to the same vaccination schedule. The number of CD3+, CD8+ and TCRγδ+ cells was significantly lower in MDV infected thymus, spleen and cecal tonsils in comparison to that found in the control organs. The proportion of CD4+ was also distinctly reduced in the thymus and limited in the spleen of MDV infected hens. This study revealed that infection with field vv+MDV isolates might break post-vaccinal protection and influence the central and peripheral immune system. The decrease in CD8+ and TCRγδ+ cell number in the thymus, spleen and cecal tonsils suggests that primarily these cells are involved in cell-mediated cytotoxicity against MDV transformed cells during latency.

  5. The effectiveness of mass vaccination on Marek's disease virus (MDV) outbreaks and detection within a broiler barn: a modeling study.

    Science.gov (United States)

    Atkins, Katherine E; Read, Andrew F; Walkden-Brown, Stephen W; Savill, Nicholas J; Woolhouse, Mark E J

    2013-12-01

    Marek's disease virus (MDV), a poultry pathogen, has been increasing in virulence since the mid twentieth century. Since multiple vaccines have been developed and widely implemented, losses due to MDV have decreased. However, vaccine failure has occurred in the past and vaccine breakthroughs remain a problem. Failure of disease control with current vaccines would have significant economic and welfare consequences. Nevertheless, the epidemiology of the disease during a farm outbreak is not well understood. Here we present a mathematical model to predict the effectiveness of vaccines to reduce the outbreak probability and disease burden within a barn. We find that the chance of an outbreak within a barn increases with the virulence of an MDV strain, and is significantly reduced when the flock is vaccinated, especially when there the contaminant strain is of low virulence. With low quantities of contaminated dust, there is nearly a 100% effectiveness of vaccines to reduce MDV outbreaks. However, the vaccine effectiveness drops to zero with an increased amount of contamination with a middle virulence MDV strain. We predict that the larger the barn, and the more virulent the MDV strain is, the more virus is produced by the time the flock is slaughtered. With the low-to-moderate virulence of the strains studied here, the number of deaths due to MDV is very low compared to all-cause mortality regardless of the vaccination status of the birds. However, the cumulative MD incidence can reach 100% for unvaccinated cohorts, and 35% for vaccinated cohorts. These results suggest that death due to MDV is an insufficient metric to assess the prevalence of MDV broiler barns regardless of vaccine status, such that active surveillance is required to successfully assess the probability of MDV outbreaks, and to limit transmission of MDV between successive cohorts of broiler chickens. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  6. Critical role of the virus-encoded microRNA-155 ortholog in the induction of Marek's disease lymphomas.

    Directory of Open Access Journals (Sweden)

    Yuguang Zhao

    2011-02-01

    Full Text Available Notwithstanding the well-characterised roles of a number of oncogenes in neoplastic transformation, microRNAs (miRNAs are increasingly implicated in several human cancers. Discovery of miRNAs in several oncogenic herpesviruses such as KSHV has further highlighted the potential of virus-encoded miRNAs to contribute to their oncogenic capabilities. Nevertheless, despite the identification of several possible cancer-related genes as their targets, the direct in vivo role of virus-encoded miRNAs in neoplastic diseases such as those induced by KSHV is difficult to demonstrate in the absence of suitable models. However, excellent natural disease models of rapid-onset Marek's disease (MD lymphomas in chickens allow examination of the oncogenic potential of virus-encoded miRNAs. Using viruses modified by reverse genetics of the infectious BAC clone of the oncogenic RB-1B strain of MDV, we show that the deletion of the six-miRNA cluster 1 from the viral genome abolished the oncogenicity of the virus. This loss of oncogenicity appeared to be primarily due to the single miRNA within the cluster, miR-M4, the ortholog of cellular miR-155, since its deletion or a 2-nucleotide mutation within its seed region was sufficient to inhibit the induction of lymphomas. The definitive role of this miR-155 ortholog in oncogenicity was further confirmed by the rescue of oncogenic phenotype by revertant viruses that expressed either the miR-M4 or the cellular homolog gga-miR-155. This is the first demonstration of the direct in vivo role of a virus-encoded miRNA in inducing tumors in a natural infection model. Furthermore, the use of viruses deleted in miRNAs as effective vaccines against virulent MDV challenge, enables the prospects of generating genetically defined attenuated vaccines.

  7. Evaluation of factors influencing the development of late Marek's disease virus-induced immunosuppression: virus pathotype and host sex.

    Science.gov (United States)

    Faiz, Nik M; Cortes, Aneg L; Guy, James S; Fletcher, Oscar J; Cimino, Thomas; Gimeno, Isabel M

    2017-08-01

    Marek's disease virus (MDV) is a herpesvirus that induces lymphoma and immunosuppression in chickens. MDV-induced immunosuppression (MDV-IS) is complex and can be divided into two phases: early-MDV-IS associated with cytolytic infection in the lymphoid organs in chickens lacking maternal antibodies against MDV (MAbs) and late-MDV-IS that appears later in the pathogenesis and occurs even in chickens bearing MAbs. We have recently developed a model to reproduce late-MDV-IS under laboratory conditions. This model evaluates late-MDV-IS indirectly by assessing the effect of MDV infection on the efficacy of infectious laryngotracheitis (ILT) vaccines against challenge with ILT virus. In the present study, we have used this model to investigate the role of two factors (MDV pathotype and host sex) on the development of late-MDV-IS. Five MDV strains representing three different pathotypes: virulent (vMDV; 617A, GA), very virulent (vvMDV; Md5), and very virulent plus (vv+MDV; 648A, 686), were evaluated. Only vv+ strains were able to induce late-MDV-IS. An immunosuppression rank (IS-rank) was established based on the ability of MDV to reduce the efficacy of chicken embryo origin vaccine (values go from 0 to 100, with 100 being the highest immunosuppressive ability). The IS-rank of the evaluated MDV strains ranged from 5.97 (GA) to 20.8 (617A) in the vMDV strains, 5.97 to 16.24 in the vvMDV strain Md5, and 39.08 to 68.2 in the vv+ strains 648A and 686. In this study both male and female chickens were equally susceptible to MDV-IS by vv+MDV 686. Our findings suggest that late-MDV-IS is a unique feature of vv+ strains.

  8. Persistence of chicken anemia virus antigen and inclusions in spontaneous cases of Marek's disease visceral lymphomas in broiler chickens at slaughterhouses.

    Science.gov (United States)

    Ahmed, Mohamed Sabry; Ono, Hiroki; Sasaki, Jun; Ochiai, Kenji; Goryo, Masanobu

    2016-06-01

    The chicken anemia virus (CAV) and Marek's disease virus (MDV) infect chickens worldwide; a single or dual infection by these viruses has a great impact on poultry production. In the present study, we examined the existence of CAV antigen and its inclusions in Marek's disease (MD) lymphomas in chickens in the slaughterhouses of Iwate prefecture, Japan. Forty-nine spleens and 13 livers with different degrees of nodular lesions were histopathologically examined at our laboratory. Grossly, the tested organs showed various sizes and anatomical architectures. Based on the cellular morphology and the infiltrative nature of the neoplastic lymphocytes, MD was confirmed in 76% (37/49) of the spleens and 92% (12/13) of the livers. The lesions of MD, according to the pattern of lymphocytic accumulation in the affected organs, were divided into multifocal, coalesced and diffuse. CAV intranuclear inclusion bodies were detected within the small and the large bizarre lymphocytes of the MD lymphomas in 2 livers and 9 spleens, and the immunostaining test for CAV confirmed the persistence of CAV antigens and inclusions in the neoplastic cells. This study demonstrated the persistence of CAV infection within the neoplastic cells of naturally occurring MD lymphomas in chickens.

  9. Differential expression of Toll-like receptor pathway genes in chicken embryo fibroblasts from chickens resistant and susceptible to Marek's disease.

    Science.gov (United States)

    Haunshi, Santosh; Cheng, Hans H

    2014-03-01

    The Toll-like receptor (TLR) signaling pathway is one of the innate immune defense mechanisms against pathogens in vertebrates and invertebrates. However, the role of TLR in non-MHC genetic resistance or susceptibility to Marek's disease (MD) in the chicken is yet to be elucidated. Chicken embryo fibroblast (CEF) cells from MD susceptible and resistant lines were infected either with Marek's disease virus (MDV) or treated with polyionosinic-polycytidylic acid, a synthetic analog of dsRNA, and the expression of TLR and pro-inflammatory cytokines was studied at 8 and 36 h posttreatment by quantitative reverse transcriptase PCR. Findings of the present study reveal that MDV infection and polyionosinic-polycytidylic acid treatment significantly elevated the mRNA expression of TLR3, IL6, and IL8 in both susceptible and resistant lines. Furthermore, basal expression levels in uninfected CEF for TLR3, TLR7, and IL8 genes were significantly higher in resistant chickens compared with those of susceptible chickens. Our results suggest that TLR3 together with pro-inflammatory cytokines may play a significant role in genetic resistance to MD.

  10. Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion.

    Science.gov (United States)

    Jarosinski, Keith W; Hunt, Henry D; Osterrieder, Nikolaus

    2010-09-30

    Marek's disease is a devastating neoplastic disease of chickens caused by Marek's disease virus (MDV). MDV down-regulates surface expression of MHC class I molecules, although the mechanism has remained elusive. MDV harbors a UL49.5 homolog that has been shown to down-regulate MHC class I expression in other Varicelloviruses. Using in vitro assays, we showed that MDV pUL49.5 down-regulates MHC class I directly and identified its cytoplasmic tail as essential for this function. In vivo, viruses lacking the cytoplasmic tail of pUL49.5 showed no differences in MD pathogenesis compared to revertant viruses in highly susceptible chickens of the B(19)B(19) MHC class I haplotype, while there was a mild reduction in pathogenic potential of the deletion viruses in chickens more resistant to MD pathogenesis (MHC:B(21)B(21)). We concluded that the pathogenic effect of MHC class I down-regulation mediated by pUL49.5 is small because virus immune evasion possibly requires more than one viral protein. Copyright 2010 Elsevier Inc. All rights reserved.

  11. MHC expression on spleen lymphocyte subsets in genetically resistant and susceptible chickens infected with Marek's disease virus.

    Science.gov (United States)

    Dalgaard, Tina; Boving, Mette K; Handberg, Kurt; Jensen, Karin H; Norup, Liselotte R; Juul-Madsen, Helle R

    2009-10-01

    Resistance and susceptibility to Marek's disease (MD) are strongly influenced by the chicken major histocompatibility complex (MHC). In this study, splenic lymphocytes from MD-resistant and MD-susceptible chickens of three MHC genotypes (B21/B21, B19/B21, and B19/B19) were analyzed by flow cytometry for MHC surface expression. In the spleen, constitutive MHC class I surface expression was found to be highest in homozygous B19, lowest in homozygous B21, and intermediate in heterozygous B19/B21 animals. This was observed on CD4(+), CD8(+), and Bu-1(+) splenic lymphocytes. Chickens of all three genotypes were subjected to infection with MD virus (GA strain) and spleen samples from infected as well as MHC-matched negative controls were analyzed at 1, 4, and 8 wk post-infection (p.i.). It was observed that MDV induced an increase in MHC class I expression late in the infection. Thus, MHC class I was increased on the surface of CD4(+) cells from infected chickens of all genotypes at 4 and 8 wk p.i. compared with negative controls. Also, MHC class I expression was increased on CD8(+) cells from infected chickens of all genotypes at 4 and 8 wk p.i., except for the homozygous B19 animals, that showed no increase at 8 wk p.i. MDV-induced differences in MHC class II surface levels were also found. Thus, MHC class II expression was increased on CD4(+) cells from infected B19/21 and B21/B21 chickens at 4 wk p.i., and also at 8 wk p.i. on CD4(+) cells from infected B19/B21 animals. MHC class II expression was increased on CD8(+) cells from infected chickens of all genotypes at 4 wk p.i. These findings suggest that MDV infection in vivo increases the level of MHC surface expression on splenic T cells, indicating a possible role in immunity against MDV.

  12. Optimization of the protocols for double vaccination against Marek's disease by using commercially available vaccines: evaluation of protection, vaccine replication, and activation of T cells.

    Science.gov (United States)

    Gimeno, Isabel M; Cortes, Aneg L; Witter, Richard L; Pandiri, Arun R

    2012-06-01

    Revaccination against Marek's disease is a widespread practice in some countries. The rationale of this practice is unknown, and there is no consensus in the protocols. Recently, we have demonstrated that administration of the first vaccine at 18 days of embryonation followed by a more protective second vaccine at hatch (18ED/1d) reproduced systematically the benefits of revaccination under laboratory conditions. Here, we have used the same model to optimize the revaccination protocols by using currently available vaccines and to determine whether two features associated with Marek's disease vaccine-induced protection (activation of T cells and replication of vaccine virus) are involved in the revaccination protocols. Protection conferred by three revaccination protocols (turkey herpesvirus [HVT] 18ED/HVT+SB-1 1d, HVT 18ED/CVI988 1d, and HVT+SB-1 18ED/ CVI988 1d) was evaluated. Revaccination protocols also were compared with single vaccination protocols (HVT 18ED, HVT+SB-1 18ED, HVT+SB-1 1d, CVI988 18ED, and CVI988 1d). Our results demonstrated that it is possible to improve efficacy of the currently available vaccines by using them in revaccination programs. Administration of HVT 18ED/CVI988 1d and HVT+SB-1 18ED/CVI988 1d were the two protocols that conferred the highest protection against a very early challenge (2 days of age) with very virulent plus Marek's disease virus strain 648A. In a separate experiment, we evaluated vaccine replication and activation of T cells in single and revaccination protocols. Our results demonstrated that replication of the second vaccine, although decreased compared with single vaccination, could be detected at 3 days (HVT, CVI988) or at 6 days (SB-1). Administration of the first vaccine (HVT) at 18ED resulted in a high percentage of activated T cells. Administration of a second vaccine (either HVT-SB-1 or CVI988) at 1d resulted in increased intensity of MHC-II stain in activated T cells.

  13. Differentially expressed genes during spontaneous lytic switch of Marek's disease virus in lymphoblastoid cell lines determined by global gene expression profiling.

    Science.gov (United States)

    Mwangi, William N; Vasoya, Deepali; Kgosana, Lydia B; Watson, Mick; Nair, Venugopal

    2017-04-01

    Marek's disease virus (MDV), an alphaherpesvirus of poultry, causes Marek's disease and is characterized by visceral CD4+TCRαβ+ T-cell lymphomas in susceptible hosts. Immortal cell lines harbouring the viral genome have been generated from ex vivo cultures of MD tumours. As readily available sources of large numbers of cells, MDV-transformed lymphoblastoid cell lines (LCLs) are extremely valuable for studies of virus-host interaction. While the viral genome in most cells is held in a latent state, minor populations of cells display spontaneous reactivation identifiable by the expression of lytic viral genes. Spontaneous reactivation in these cells presents an opportunity to investigate the biological processes involved in the virus reactivation. For detailed characterization of the molecular events associated with reactivation, we used two lymphoblastoid cell lines derived from lymphomas induced by pRB1B-UL47eGFP, a recombinant MDV engineered to express enhanced green fluorescent protein (EGFP) fused with the UL47. We used fluorescence-activated cell sorting to purify the low-frequency EGFP-positive cells with a spontaneously activating viral genome from the majority EGFP-negative cells and analysed their gene expression profiles by RNA-seq using Illumina HiSeq2500. Ingenuity pathway analysis on more than 2000 differentially expressed genes between the lytically infected (EGFP-positive) and latently infected (EGFP-negative) cell populations identified the biological pathways involved in the reactivation. Virus-reactivating cells exhibited differential expression of a significant number of viral genes, with hierarchical differences in expression levels. Downregulation of a number of host genes including those directly involved in T-cell activation, such as CD3, CD28, ICOS and phospholipase C, was also noticed in the LCL undergoing lytic switch.

  14. A deletion within glycoprotein L of Marek's disease virus (MDV) field isolates correlates with a decrease in bivalent MDV vaccine efficacy in contact-exposed chickens.

    Science.gov (United States)

    Tavlarides-Hontz, Phaedra; Kumar, Pankaj M; Amortegui, Juliana Rojas; Osterrieder, Nikolaus; Parcells, Mark S

    2009-06-01

    We examined the functional role of a naturally occurring deletion within the glycoprotein L (gL) gene of Marek's disease virus (MDV) field isolates. We previously showed that this mutation incrementally increased the virulence of an MDV in contact-exposed SPF leghorn chickens, when chickens shedding this virus were co-infected with herpesvirus of turkeys (HVT). In our present study, we examined this mutation using two stocks of the very virulent plus (vv+)MDV strain TK, one of which harbored this deletion (TK1a) while the other did not (TK2a). We report that TK1a replicating in vaccinated chickens overcame bivalent (HVT/SB1) vaccine protection in contact-exposed chickens. Treatment groups exposed to vaccinated chickens inoculated with a 1:1 mix of TK1a and TK2a showed decreased bivalent vaccine efficacy, and this decrease correlated with the prevalence of the gL deletion indicative of TK1a. These results were also found using quadruplicate treatment groups and bivalently vaccinated chickens obtained from a commercial hatchery. As this deletion was found in 25 out of 25 recent field isolates from Delaware, Maryland, North Carolina, Pennsylvania, and Virginia, we concluded that there is a strong selection for this mutation, which appears to have evolved in HVT or bivalently vaccinated chickens. This is the first report of a mutation in a vv+MDV field strain for which a putative biological phenotype has been discerned. Moreover, this mutation in gL has apparently been selected in MDV field isolates through Marek's disease vaccination.

  15. LAAnAA v VVVV v

    Indian Academy of Sciences (India)

    subject matter to which statistics is to be applied. Fisher became an ecologist, evolutionary geneticist and agronomist all in one. He was a living example of interdisciplinary research. This book written by his daughter, Joan Fisher Box is inspiring reading for any budding scientist. Suggested Reading. • Fisher, R.A., 1925 ...

  16. Pop / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2003-01-01

    Heliplaatidest: Myslovitz "Korova Milky Bar", Sting "Sacred Love", Erinevad esitajad "Complications. Exogenic Breaks Compilation vol.1", Erinevad esitajad "An Anthology of Noise & Electronic Music Volume #2", Headphone Science "We Remain Faded", Mark Eitzel "The Ugly American"

  17. Pop / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2005-01-01

    Heliplaatidest: Cardigans "Super Extra Gravity", Earth, Wind & Fire "Illumination", Stevie Wonder "A Time To Love", Shout Out Louds "Howl Howl Gaff Gaff", Goldie Lookin Chain "Safe As Fuck", Ms. Dynamite "Judgement Days", Echosilence "Distorted Horizon", Bob Dylan "No Direction Home"

  18. [Uued heliplaadid] / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    1999-01-01

    Uutest heliplaatidest: The Cranberries "Bury The Hatchet", Naughty By Nature "Nineteen Naughty Nine: Nature"s Fury", erinevad esitajad "INCredible Sound of Drum"n"Bass: Mixed by Goldie", New Radicals "Maybe You"ve Been Brainwashed Too"

  19. Pop / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2002-01-01

    Heliplaatidest Mobb Deep "Infamy". Hilmar Örn Hilmarsson & Sigur Ros "Angels Of The Universe". Simple Minds"The Best of". Angie Stone "Mahogany Soul". Cypress Hill "Stoned Raiders". Bebel Gilberto "Tanto Tempo Remixes". Roots Manuva "Run Come Save Me"

  20. Lugemisnoppeid: antropoloogia / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2012-01-01

    Tutvustus: Jürgenson, Aivar. Ladina rahva seas : Argentina ja sealsed eestlased. Tallinn, 2011 ; Annist, Aet. Otsides kogukonda sotsialismijärgses keskuskülas : arenguantropoloogiline uurimus. Tallinn : Tallinna Ülikooli Kirjastus, 2011. (Acta Universitatis Tallinnensis. Socialia) ; Hiiemäe, Reet. Kaitsemaagia eesti rahvausundis. Tallinn, 2012 ; Augé, Marc. Kohad ja mittekohad : sissejuhatus ülimodernsuse antropoloogiasse. Tallinn : Tallinna Ülikooli Kirjastus, 2012. (Bibliotheca controversiarum)

  1. Uued heliplaadid / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    1999-01-01

    Heliplaatide tutvustus : Sixpence None The Richer "Sixpence None The Richer", Erinevad esitajad "No Boundaries - A Benefit For The Kosovar Refugees", K-Ci & JoJo "It's Real", Limp Bizkit "Significant Other"

  2. Pop / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2005-01-01

    Heliplaatidest: Kano "Home Sweet Home", Static-X "Start A War", Kraftwerk "Minimum Maximum", The Juan Maclean "Less Than Human", Andrian Belew "Side Two", Saint Etienne "Tales From Turnpike House", Jamie Cullum "Pointless Nostalgic", James Blunt "Back To Bedlam", Architecture In Helsinki "In Case We Die"

  3. Jumalate enesetapp / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2009-01-01

    Autori sõnul on enesepõlgus ja -vihkamine, millega Lääne kultuurieliit on tegelnud J.-P. Sartréíst alates, tekitanud olukorra, kus islami kritiseerimine toob kaasa meediakisa ja tapmisähvardused; kristlust, valget rassi ja Läänt tervikuna võib aga mõnitada ükskõik kui jõhkralt

  4. Meeleparanduslik teater / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2006-01-01

    Autor tunneb muret ühe uue tendentsi pärast, mida kohtab nii teatri NO99 ja Von Krahli viimastes lavastustes ("Nafta" ja "Võluflööt") kui teisteski teatrites (Linnateatri "Genoom"). Seda tendentsi nimetab ta "meeleparanduslikuks teatriks" ja näeb selles mitmeid probleeme

  5. Syngeneic lysis of reticuloendotheliosis virus-transformed cell lines transfected with Marek's disease virus genes by virus-specific cytotoxic T cells.

    Science.gov (United States)

    Uni, Z; Pratt, W D; Miller, M M; O'Connell, P H; Schat, K A

    1994-12-01

    Cell-mediated immune responses against Marek's disease virus (MDV) antigens were examined using reticuloendotheliosis virus (REV)-transformed cell lines of two haplotypes (B19B19 and B13B13). These cell lines were stably transfected with cloned fragments of MDV DNA resulting in the expression of the MDV-specific phosphoprotein pp38. Effector cells were obtained from P2a (B19B19) and S13 (B13B13) chickens at 7 days post inoculation with REV, oncogenic or attenuated serotype 1 MDV (JM-16/O and JM-16/A, respectively), serotype 2 MDV (SB-1), or herpesvirus of turkeys (HVT). Transfection of MDV genes did not influence the expression of Class I major histocompatibility complex antigens. The optimal effector to target cell ratio was determined to be 100:1. REV-sensitized effector cells lysed REV cell lines and REV cell lines transfected with MDV DNA in a syngeneic fashion. Effector cells from chickens inoculated with JM-16/O, JM-16/A, SB-1 or HVT lysed only the syngeneic, transfected cell lines, but not the parent REV cell lines. The percentage specific release caused by the MDV-sensitized effector cells was low, but statistically significant.

  6. Sequence variations of the MHC class I gene exon 2 and exon 3 between infected and uninfected chickens challenged with Marek's disease virus.

    Science.gov (United States)

    Wang, Ye; Qiu, Mohan; Yang, Jiandong; Zhao, Xiaoling; Wang, Yan; Zhu, Qing; Liu, Yiping

    2014-01-01

    The major histocompatibility complex (MHC) among chickens has been well established as being associated with disease resistance and pathogens infection, but the genetic differences in MHC between chickens susceptible to certain infections and those chickens that remain uninfected have not been sufficiently determined. In this study, we sought the genetic basis that may underlie differences in susceptibility to infection among chickens by challenging four groups of broilers with Marek's disease virus (MDV). Over the course of the experiment, lesions began to appear between 21 and 35 days post challenge (dpc), and commercial broilers were not necessarily better than indigenous chickens in terms of disease resistance. The four groups showed neutral resistance to MDV infection validated by challenge results and evolutionary analysis of exons 2 and 3 of the MHC class I region. Several variable sites in exon 2 and exon 3 were exclusively appeared in infected chickens. Exon 3 was likely more crucial than exon 2 in disease resistance. Our observations offered a support for a potential association between promiscuous pathogens and conspicuous genetic diversity in the MHC class I region. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Quantitation of Marek's disease and chicken anemia viruses in organs of experimentally infected chickens and commercial chickens by multiplex real-time PCR.

    Science.gov (United States)

    Davidson, Irit; Raibshtein, I; Al-Touri, A

    2013-06-01

    The worldwide distribution of chicken anemia virus (CAV) and Marek's disease virus (MDV) is well documented. In addition to their economic significance in single- or dual-virus infections, the two viruses can often accompany various other pathogens and affect poultry health either directly, by causing tumors, anemia, and delayed growth, or indirectly, by aggravating other diseases, as a result of their immunosuppressive effects. After a decade of employing the molecular diagnosis of those viruses, which replaced conventional virus isolation, we present the development of a real-time multiplex PCR for the simultaneous detection of both viruses. The real-time PCRs for MDV and for CAV alone are more sensitive than the respective end-point PCRs. In addition, the multiplex real-time shows a similar sensitivity when compared to the single real-time PCR for each virus. The newly developed real-time multiplex PCR is of importance in terms of the diagnosis and detection of low copies of each virus, MDV and CAV in single- and in multiple-virus infections, and its applicability will be further evaluated.

  8. ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

    CERN Multimedia

    Visual Media Office

    2013-01-01

    ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

  9. A discussion of a book: Historiografia prasy polskiej (do 1918 roku. Naukometryczna analiza dyscypliny 1945–2009 by Władysław Marek Kolasa. Kraków: Wydawnictwo Naukowe Uniwersytetu Pedagogicznego, 2013; “Prace Monograficzne” 678, ISBN 0239-6025, 978-83-7271-843-1, 525 pp. + BIbliography (CD (in Polish

    Directory of Open Access Journals (Sweden)

    Michał Kokowski

    2016-11-01

    Full Text Available This article presents a peer review of the book by Władysław Marek Kolasa on the historiography of the Polish press. It regards the methodology of historiography, the science of science and its sub-disciplines: scientometrics and bibliometrics.

  10. Characterizing the histopathology of natural co-infection with Marek's disease virus and subgroup J avian leucosis virus in egg-laying hens.

    Science.gov (United States)

    Wen, Yawen; Huang, Qi; Yang, Chengcheng; Pan, Ling; Wang, Guijun; Qi, Kezong; Liu, Hongmei

    2018-02-01

    Marek's disease virus (MDV) and avian leucosis virus (ALV) are known to cause tumours in egg-laying hens. Here, we investigated the aetiology of tumours in a flock of egg-laying hens vaccinated against MDV. We carried out gross pathology and histopathological examinations of the diseased tissues, identified virus antigen and sequenced viral oncogenes to elucidate the cause of death in 21-22-week-old hens. At necropsy, diseased hens had distinctly swollen livers, spleens, and proventriculus, and white tumour nodules in the liver. The spleen and liver had been infiltrated by lymphoid tumour cells, while the proventriculus had been infiltrated by both lymphoid tumour cells and myeloblastic cells. Subtype J ALV (ALV-J) and MDV were widely distributed in the proventricular gland cells, and the lymphoid tumour cells in the liver and the spleen. In addition, positive ALV-J signals were also observed in parts of the reticular cells in the spleen. MDV and ALV-J antigens were observed in the same foci of the proventricular gland cells; however, the two antigens were not observed in the same foci from the spleen and liver. The amino acid sequence of the AN-1 (the representative liver tumour tissue that was positive for both ALV-J and MDV) Meq protein was highly similar to the very virulent MDV QD2014 from China. Compared to the ALV-J HPRS-103 reference strain, 10 amino acids (224-CTTEWNYYAY-233) were deleted from the gp85 protein of AN-1. We concluded that concurrent infection with MDV and ALV-J contributed to the tumorigenicity observed in the flock.

  11. Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek's disease in Chinese specific pathogen-free BWEL chickens.

    Science.gov (United States)

    Gao, Caixia; Han, Lingxia; Han, Jianlin; Liu, Jiasen; Jiang, Qian; Guo, Dongchun; Qu, Liandong

    2015-01-01

    The highly polymorphic chicken major histocompatibility complex (MHC) is associated with different levels of immunologic responses to certain avian pathogens. MHC-B haplotype chickens are an important genetic resource for studying the genetic determination of pathogen resistance and susceptibility. The BWEL chicken population is the only specific pathogen-free (SPF) chickens bred and developed by the State Center of Poultry Genetic Resources of Laboratory Animals in China. In this study, we successfully established six homozygous MHC-B haplotype populations from the BWEL chickens using microsatellite marker technology, named as BW/G(1, 2, 3, 5, 6, 7) lines, and their molecular genotypes were matched to six serologically defined MHC-B haplotypes, B13, B15, B2, B5, B21 and B19, respectively. The sequences of BF genes exons 2 and 3 from four successive generations (F1-F4) of the BW/G(n) lines were completely consistent with those of serologically defined MHC-B haplotypes. Subsequently, six BW/G(n) line specific allo-antisera were prepared by immunization with red blood cells (RBCs) and hemagglutination tests results showed the BW/G(n) SPF chickens could be serologically differentiated. Additionally, susceptibility to Marek's disease (MD) in the BW/G3 (B2 haplotype) and BW/G7 (B19 haplotype) lines were determined by comparing mortality, macroscopic and histopathological lesions, and viral loads in feather pulp. The BW/G7 line showed greater genetic susceptibility to the very virulent MD virus (MDV) strain than the BW/G3 line. The establishment of MHC-B haplotype chicken populations associated with susceptibility to MD will be helpful for studying host immune responses and further developing the more effective vaccines in the context of MHC specificities, and they are also very useful for an understanding of MHC genes architecture and function. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. Expression kinetics of chicken β2-microglobulin and Class I MHC in vitro and in vivo during Marek's disease viral infections.

    Science.gov (United States)

    Yu, Chuan; Liu, Qiu; Qin, Aijian; Hu, Xuming; Xu, Wencai; Qian, Kun; Shao, Hongxia; Jin, Wenjie

    2013-12-01

    Marek's disease virus (MDV) is a highly cell-associated herpesvirus that causes a disease in chickens characterized by tumor formation and immunosuppression. The changes of major histocompatibility complex (MHC) expression in different MDV-infected cells are not completely understood. In this study, we investigated the expression of the Class I MHC and β2-microglobulin (β2m) genes in response to MDV infection at different time points by real-time PCR. In both in vitro and in vivo, the expression levels of Class I MHC and β2m genes were upregulated during early MDV infections in comparison to control cells; We also found that the expression of Class I MHC gene was downregulated in BudR (5-bromo-2'-deoxyuridine)-treated MSB1 cells at 48 h and MDV-infected chicken embryo fibroblast cells (CEF) at 120 and 168 h post infection (hpi); Furthermore, compared to control groups, Class I MHC and β2m expression levels were downregulated in peripheral blood lymphocytes (PBLC) from MDV-infected chickens at 14 and 28 days post infection (dpi); Interestingly, both Class I MHC and β2m gene expression levels increased again in PBLC from MDV RB1B-infected chickens at 35 dpi, in which MDV was in the latent or transformed infection stages. In addition, Class I MHC expression was clearly decreased in MDV-infected CEF at 120 hpi although β2m expression was significantly increased. These changes in Class I MHC and β2m gene expression might provide more insights into host-virus interaction.

  13. Building on success / Edward Lucas

    Index Scriptorium Estoniae

    Lucas, Edward

    2007-01-01

    Eesti edust 1990ndatel aastatel. Kuid 2007. a. parlamendivalimised näitasid, et Eestis nagu teistes endistes kommunistlikes maades puudub reformialdis valitsus. Kiitust pälvib Eesti president Toomas Hendrik Ilves, kes pani veto pronkssõduri seadusele ja taunis Eesti iseseisvuspäeva pidustustel peetud kõnes korruptsiooni, enesega rahulolu ja takerdunud reforme. Vt. ka Marek Laane tõlge eesti keelde: Eesti vajab terasemat valitsust. Postimees 8. märts 2007, lk. 16

  14. Eesti Bachelard : [retseptsioonist] / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2000-01-01

    Bibl. joonealustes märkustes. Seoses Gaston Bachelard'i teoste retseptsiooniga Eestis on artiklis nimetatud Aleksander Aspelit, Tõnu Kõivu, Haljand Udamit, Mati Unti (romaan "Sügisball") ja Mihkel Mutti

  15. Rõivakaubanduse edu saladused / Marek Maido

    Index Scriptorium Estoniae

    Maido, Marek

    2014-01-01

    H & M, Zara, Mango ja Uniqlol rõhutavad majandustarkvara ERP lahenduste olulist rolli ning kasutavad neid klientide eelistuste kaardistamiseks, varude kiireks täiendamiseks ning tarneketi juhtimiseks

  16. Postuumne Bourdieu : Bourdieu / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2005-01-01

    Ka 2003. a. ilmunud Pierre Bourdieu' (1930-2002) fotoalbumist "Alžeeria pildid" (Images d'Algerie: Une affinite elective), kuhu on P. Bourdieu poolt 1958-1961 Alžeerias jäädvustatud mustvalgetest fotodest valitud ligemale 150. 2003. a. korraldati P. Bourdieu fotode põhjal Araabia Maailma Instituudis Pariisis näitus

  17. Kuidas portreteerida koolkonda? / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2017-01-01

    Arvustus: Theoretical schools and circles in the twentieth-century humanities : literary theory, history, philosophy / edited by Marina Grishakova and Silvi Salupere. New York ; London : Routledge, 2015. (Routledge interdisciplinary perspectives on literature ; 42)

  18. Ajalooliste võrdluste eetika / Michael Rothberg ; intervjueerinud Eneken Laanes

    Index Scriptorium Estoniae

    Rothberg, Michael

    2017-01-01

    Intervjuu Tallinna ülikooli külastava kultuurimälu uurija, California ülikooli professori Michael Rothbergiga. Ta on sümpoosioni "Kultuurideülesed mäluvormid: sõja, ümberasumise ja poliitiliste konfliktide mäletamine nüüdisajal" peaesineja ja peab loengu "Pärandi probleem: migratsioon ja kultuurideülene holokausti mälu nüüdisaegsel Saksamaal". Ka tema raamatutest

  19. Ainenõukogu tähelepanekuid / Ene Laanes

    Index Scriptorium Estoniae

    Laanes, Ene

    2003-01-01

    Üleriigiline kehalise kasvatuse ainenõukogu peab vajalikuks juhtida haridusametnike, koolijuhtide ja kooli omanike tähelepanu kehalise kasvatuse ainekava läbiviimisel üles kerkinud probleemidele: meditsiinilisse erigruppi kuuluvate õpilaste hindamine kehalise kasvatuse aines, kehalise kasvatuse tunniks vajalikud harjutuspaigad ja vahendid, nädalatundide arv

  20. Korp! Rotalia Los Angeleses / Bruno Laan, Jüri Tint

    Index Scriptorium Estoniae

    Laan, Bruno, 1926-

    1988-01-01

    Sisaldab ka nimekirja rotalustest ja nende perekonnaliikmetest XIV Lääneranniku Eesti Päevade juhtkonnas, Los Angelese konvendi presiidiumite nimekirja aastatest 1957-1986, Los Angelese konvendi magistrite ja ametmeeste nimekirja 1960-1986 ja konvendis peetud referaatide nimekirja 1959-1985

  1. Dieeditestide tagamaad ja võimalused / Aleksander Laane

    Index Scriptorium Estoniae

    Laane, Aleksander, 1968-

    2006-01-01

    Sõltumatu uurimus varjatud toiduallergia testidest ning arvamus nende reklaamimisest patsientidele. Kommenteerivad SA Tartu Ülikooli Kliinikumi arst-õppejõud, Eesti Immunoloogide ja Allergoloogide Seltsi president Kaja Julge ning Tallinna Tehnikaülikooli Toiduainete Instituudi direktor Raivo Vokk. Samas lisa: Väljavõte kohtu otsusest (Washingtoni osariik versus Medical Service Center, Mark Lovendale jt, 1986)

  2. Elektrienergia hajutatud tootmine Eestis / Marek Muiste

    Index Scriptorium Estoniae

    Muiste, Marek, 1979-

    2006-01-01

    Eestis on välja kujunemas uus energeetiline struktuur, mida iseloomustab ühe suure tootmisüksuse kõrval tegutsevate lokaalsete väikese võimsusega elektrijaamade võrgustik. Lokaaljaamu iseloomustab taastuvate kütuste kasutamine ja seotus regiooni üldise arenguga. Tabelid, diagrammid

  3. Kuidas õigustada esteetilist hoiakut? / Marek Volt

    Index Scriptorium Estoniae

    Volt, Marek, 1973-

    2011-01-01

    Eristatakse hoiakute-vahelist ja hoiaku-sisest õigustamist ning analüüsitakse esteetilise hoiaku episteemilist, sotsiaal-bioloogilist, moraalset, kunstilist, esteetilist ja hedoonilist õigustamist hoiaku-siseses kontekstis

  4. Propagandistlik tellimustöö? / Marek Kallin

    Index Scriptorium Estoniae

    Kallin, Marek

    2007-01-01

    Rets. rmt.: Jeremy Rifkin. Euroopa unistus. OÜ Hermes, 2007. Artikli autor väljendab üllatust, et president Toomas Hendrik Ilves pidas vajalikuks osaleda intellektuaalselt nii pinnapealse teose esitlusel

  5. Demokraatia diversiteet = Raznoobrazije form demokratii / Marek Strandberg

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2008-01-01

    Šveitsi otsedemokraatia süsteemist ja selle rakendamisest Eestis esindusdemokraatliku võimu kõrval. Diagramm: Šveitsi rahvaalgatuslike ja kohustuslike referendumite tulemused 1848-2005. Ajaleht Poljana nr. 4

  6. Orienteerumiskaart vs. LiDAR / Marek Karm

    Index Scriptorium Estoniae

    Karm, Marek

    2012-01-01

    Bakalaureusetööst, mille eesmärk oli võrrelda orienteerumiskaardi reljeefi LiDAR-i andmete põhjal saadava reljeefimudeliga ning leida vastus küsimusele, kas o-kaart võib olla kasulik kooste- või kontrollmaterjal mistahes reljeefimudelile

  7. Semiootikud elavad edasi. Ka Tartus / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2000-01-01

    Arvustus: Sign System Studies. Vol. 26. Tartu : Tartu Ülikooli Kirjastus, 1998 ; Sign System Studies. Vol. 27. Tartu : Tartu Ülikooli Kirjastus, 1999 ; Kultuurisemiootika teesid / V. Ivanov, J. Lotman, A. Pjatigorski... jt. Tartu : Tartu Ülikooli Kirjastus, 1998. (Tartu Semiotics Library ; 1). Tekst vene, inglise ja eesti k. ; Tartu-Moskva semiootikakoolkonna mõistesõnastik / toim. Jan Levtshenko. Tartu : Tartu Ülikooli Kirjastus, 1999 (Tartu Semiotics Library ; 2). Tekst vene k. Osa teksti eesti ja inglise k

  8. Eesti koolid ei jaksa enam Microsoftilt tarkvara osta / Teele Tammeorg ; kommenteerinud Rain Laane

    Index Scriptorium Estoniae

    Tammeorg, Teele

    2013-01-01

    Eesti koolide arvutid on nii vananenud, et ei saa kasutada uuemaid operatsioonisüsteeme, Windowsi operatsioonisüsteem ja MS Office'i kasutamine aga kallineb vähemalt kümme korda. Arvamust avaldab ka Tallinna ülikooli haridustehnoloogia keskuse juht Mart Laanpere

  9. Kõrvalseisja pilk Eesti tervishoiule / Martin McKee ; interv. Triinu Laan

    Index Scriptorium Estoniae

    McKee, Martin

    2008-01-01

    Londoni Ülikooli rahvatervise professor annab hinnangu Eesti tervishoiusüsteemi arengule, Eesti esmatasandi arstiabile, Eesti tervishoiusummade kasutamisele ning tervise edendamisele ja haiguste ennetamisele Eestis. Probleemidest Eesti tervishoiusüsteemis; Eestis toimuvast WHO ministrite konverentsist

  10. Hulluse tõde mõistuse ajastul / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2004-01-01

    Rets. rmt.: Foucault, Michel. Hullus ja arutus. Hullumeelsuse ajalugu klassikalisel ajastul. Tartu, 2003 ; Foucault, Michel. Le pouvoir psychiatrique. Cours au College de France, 1973-1974. Pariis, 2003. Samal teemal : Vahing, Vaino. Ühiskond ja vaimuhaigus, lk. B10

  11. "800 aastat" - millest ja milleks? / Linda Kaljundi, Marek Tamm

    Index Scriptorium Estoniae

    Kaljundi, Linda, 1979-

    2008-01-01

    Tallinna Ülikooli keskaja keskuse ja Põhjamaade keskajauuringute keskuse koostöös Tallinnas 22.-24. maini korraldatavast konverentsist "The Chronicle of Henry of Livonia : Crusading and Chronicle Writing at the Medieval Baltic Frontier"

  12. Outbreaks of Marek's Disease in Layer Chickens Farms in Khartoum ...

    African Journals Online (AJOL)

    ... that infection of MD in vaccinated adult commercial type chickens might be due to de novo infection (Super infection) with highly virulent strains despite existing considerable levels of vaccine immunity and age resistance, also vaccination failure may perhaps considered one of the important causes of disease outbreaks.

  13. Marek's disease virus induced transient paralysis--a closer look

    Science.gov (United States)

    Marek’s Disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly cell-associated alpha herpesvirus, Marek’s disease virus (MDV). Clinical signs of MD include depression, crippling, weight loss, and transient paralysis (TP). TP is a disease of the central nervous system...

  14. Towards modern STI policy-making in Estonia / Marek Tiits

    Index Scriptorium Estoniae

    Tiits, Marek

    2003-01-01

    Autor arutleb rahvusliku tehnoloogia-, innovatsiooni- ja teaduspoliitika vajalikkuse üle ning leiab, et Eesti majanduslik areng peaks tulevikus põhinema eelkõige hariduse, teaduse ja innovatsiooni kvaliteedi tõstmisel

  15. Sokali afäär : 'postmodernismi' kriitikat / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    1997-01-01

    Kaasaegsete kultuuriteooriate kriitikast, eriti Alan D. Sokali paroodiast 'Piiride rikkudes: kvantgravitatsiooni hermeneutilise transformatsiooni poole' (Social Text 1996 (kevad-suvi), nr. 46/47) ning A. D. Sokali ja Jean Bricmont'i pamfletist 'Intellektuaalsed pettused' (Paris, 1997)

  16. Kolm Goncourt'i laureaati korraga / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2002-01-01

    Arvustus: Tournier, Michel. Haldjakuningas / tlk. Laine Hone. Tallinn : Eesti Raamat, 2002 ; Rouaud, Jean. Auväljad / tlk. Vladimir Indrikson. Tallinn : Atlantis, 2002 ; Roze, Pascale. Hävituslendur Zéro / tlk. Kaja Riesen. Tallinn : Olion, 2002

  17. Kuidas kirjutatakse ajalugu? / Roger Chartier ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Chartier, Roger

    2007-01-01

    Kirjanduslikest tekstidest sotsiaalajaloo uurimisallikana, juhuse ja paratamatuse vahekorrast ajaloos ja Prantsuse revolutsiooni käsitlusest Pariisi õppe- ja teaduskeskuse Ecole des Hautes Etudes en Sciences Sociales professori R. Chartier'i teostes. Varem ilm.: Tekstid, praktikad ja lugejad : intervjuu Roger Chartier'ga // Chartier, Roger. Prantsuse revolutsiooni kultuurilised lätted. - Tallinn, 2002. - Lk. 274-290

  18. Kuidas kirjutatakse ajalugu? / Alain Corbin ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Corbin, Alain

    2007-01-01

    Pariis I Ülikooli emeriitprofessori A. Corbini teoste temaatikast ja uurimistöödest. Varem ilm.: Emotsioonid, tunded ja kired : intervjuu Alain Corbiniga // Corbin, Alain. Kannibalide küla : hirm ja raev 19. sajandi Prantsusmaal. - Tallinn, 2000. - Lk. 187-195

  19. Kuidas lugeda "Meeste domineerimist"? / Patrick Champagne ; tlk. Marek Tamm

    Index Scriptorium Estoniae

    Champagne, Patrick

    2005-01-01

    Rets. rmt.: Bourdieu, Pierre. Meeste domineerimine. Tallinn, 2005. Kommenteerivad (lk. 12-14) Liina Lukas, Rein Ruutsoo (TLÜ õppejõud), Marina Grišakova, Aare Pilv, Airi-Alina Allaste, Raivo Vetik (TLÜ Õppejõud), Andres Härm, Voldemar Tomusk

  20. 9 CFR 113.330 - Marek's Disease Vaccines.

    Science.gov (United States)

    2010-01-01

    ... of plaque forming units (pfu) used in the immunogenicity test prescribed in paragraph (c) of this section, but not less than 1000 pfu per dose. (iii) When tested (without the pretest incubation of... have a virus titer per dose which is at least 2 times the number of pfu used in the immunogenicity test...

  1. Kuidas kirjutatakse ajalugu? / Jacques Revel ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Revel, Jacques

    2007-01-01

    Prantsuse ajaloolase ja ajakirja Annales ühe peatoimetaja J. Revel'i erialasest tegevusest ja teostest. Varem. ilm.: Sündmused, jutustus ja analüüsiskaalad : intervjuu Jacques Reveliga // Revel, Jacques, Farge, Arlette. Mässu loogika : lasteröövlite afäär Pariisis 1750. - Tallinn, 2005. - Lk. 109-123

  2. McCain, Lieberman ja meie / Marek Strandberg, Indrek Tarand

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2005-01-01

    USA senaatorite, vabariiklase John McCaini ja demokraat Joe Liebermani poolt USA senati menetlusse antud kahest seaduseelnõust, millest esimene kohustab USA presidenti astuma samme Venemaa ajutiseks väljaheitmiseks rikaste riikide ühendusest G7 ja teine on tuntud kui Climate Stewardship Act ehk kliimahoole seaduseelnõu. Artikli autorid Ilmahoole algatusrühmast kutsuvad üles toetama McCaini-Liebermani initsiatiivi, mis kaitseb ka Eesti välispoliitika huve

  3. Kuidas kirjutatakse ajalugu? / Natalie Zemon Davis ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Davis, Natalie Zemon

    2007-01-01

    Ülevaade Princentoni Ülikooli emeriitprofessori ja Ameerika Ajalooühingu endise presidendi N. Z. Davis'e teostest. Varem ilm.: Ajalugu, filmikunst ja heidikud : intervjuu Natalie Zemon Davisega // Davis, Natalie Zemon. Martin Guerre'i tagasitulek. - Tallinn, 2002. - Lk. 162-177

  4. Carlo Ginzburg: anomaalia viitab normile / intervjueerinud Marek Tamm

    Index Scriptorium Estoniae

    Ginzburg, Carlo, 1939-

    2014-01-01

    Intervjuu itaalia ajaloolase Carlo Ginzburgiga tema raamatu "Ükski saar pole saar : neli pilguheitu inglise kirjandusele globaalsest vaatenurgast" eesti keeles ilmumise puhul. Teos ilmus Tallinna Ülikooli Kirjastuses

  5. Pariisi kiri. Kevadine raamatuhooaeg : [1999. a.] / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    1999-01-01

    Ka Pariisi rahvusvahelisest raamatumessist. Rets. rmt.: Genette, Gérard. Figures IV. S. l. : Seuil, 1999; Eribon, Didier. Arutlused gay-küsimusest. Pariis : Fayard, 1999. Eco, Umberto. Kant ja nokkloom. Pariis : Grasset, 1999 (prantsuse keeles, originaal itaalia k.: Milaano: Bompiani, 1997)

  6. Teenuste arendamise riigi raha kohalikele omavalitsustele / Marek Atonen

    Index Scriptorium Estoniae

    Atonen, Marek

    2007-01-01

    2007. aasta riigieelarve seaduse paragrahv 4 lõige 2 määratleb, millised summad on riigieelarvest eraldatud kohalikele omavalitsustele toimetulekutoetuste maksmiseks. Raha jaotuse kehtestas valitsus oma 22. veebr. 2007. a. määrusega nr. 51. Lisatud: väljavõtteid määruse seletuskirjast

  7. Kunsti hindamise ontoloogilised ja episteemilised eeldused / Marek Volt

    Index Scriptorium Estoniae

    Volt, Marek

    2006-01-01

    VKT - kunstiteose vahetu kogemuse teesi paikapidavusest. Mentalistlikud monismid. Dualistlikud ontoloogiad. Strawsoni ajalooline dualism. Surrogaadiargumendid. Personalism ja verbaalsed surrogaadid. Kirjandus lk. 67-71

  8. Millal jõudsid dominikaanid Tallinna / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2001-01-01

    Dominiiklaste ajalugu, Tallinnasse jõudmine ja lahkumine Simon Tugwelli "Historia" tõlgenduste järgi. Lisa: Historia Ordinis Praedicatorum in Dania. Eludaatumid: Dominicus, Püha, 1170-1221 ; Guillelmus, Modenast, 1184-1251

  9. Rämpsu ja sodi evangeelium / Marek Strandberg

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2008-01-01

    Autori arvates vajaks me omavalitsuste korraldatud kulupõhist jäätmekäitlusmehhanismi, kus kodanikele ei panda muid lepingulisi ja rahalisi kohustusi, kui nad on oma jäätmed kokkulepitult sorteerinud

  10. 3- ja 4-aastaste laste intellektuaalne areng erinevates kasvukeskkondades / Merit Laane, Kristina Nugin, Ingrid Tuisk, Marika Veisson

    Index Scriptorium Estoniae

    2001-01-01

    Uuringust, mille eesmärgiks oli selgitada, milline on 3- ja 4-aastaste laste intellektuaalne areng erinevates kasvukeskkondades. Uuringus osalesid longituuduurimuses osalenud lapsed, tavarühma lapsed ja Hea Alguse rühma lapsed

  11. Inimnäoline ajalugu : medievist Marek Tamm tutvustab eesti keelde jõudnud inimesekeskseid mikroajalookäsitlusi / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2001-01-01

    Arvustus: Ginzburg, Carlo. Juust ja vaglad : ühe 16. sajandi möldri maailm /tlk. Viivika Atkin. Tln. : Varrak, 2000; Barokiajastu inimene / koost. Rosario Villari; tlk. Heete Sahkal, Heigo Sooman, Piret Peiker. Tln. : Avita, 2000

  12. Transformation of Estonia's industrial structure : Continued de-industrialisation or interlude in re-industrialisation? / Garri Raagmaa, Mihkel Laan, Antti Raamat

    Index Scriptorium Estoniae

    Raagmaa, Garri, 1966-

    2003-01-01

    Autorid analüüsivad Eesti tööstuse senisele arengule tuginedes võimalikke arengusuundi tulevikus. Tabelid ja diagramm. Vt. samas: Competitiveness of the Baltic states has improved; Skanska leaves Latvia and Lithuania but not from Estonia

  13. Üldine kaubandus (toidukaupade turg) : toidukaupade väliskaubanduse bilanss [2003-2004] / Õrne Pill, Liia Laanes, Ene Maadvere

    Index Scriptorium Estoniae

    Pill, Õrne

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 55-65. Põllumajandussaaduste ekspordimaht kasvas eelmise aasta sama perioodiga võrreldes 5,1% ning impordimaht vähenes 1,8%, kaubandusbilansi negatiivne saldo moodustas 4507,7 mln krooni. Diagrammid

  14. Kas terrorismi saab neutraalselt defineerida? = Is it possible to define terrorism neutrally? / Marek Järvik

    Index Scriptorium Estoniae

    Järvik, Marek

    2006-01-01

    Terrorismi definitsioon, vägivald, poliitilised eesmärgid, terrorism ja kuritegevus, avalikkus, revolutsioon ja vabadusvõitlus. Ettekanne Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päeval "Kunstnike moraalsed valikud kultuurikonfliktides" Tallinna Kunstihoones 27.04.2006. Bibliograafia lk. 99

  15. "Kurja lillede" kuus ärakeelatud luuletust / Charles Baudelaire ; saatesõna: Marek Tamm

    Index Scriptorium Estoniae

    Baudelaire, Charles

    2000-01-01

    Sisu: Kalliskivid / tlk. Ain Kaalep ; Lethe / tlk. Märt Väljataga ; Temale, kes on liiga rõõmus / tlk. Ain Kaalep ; Lesbos / tlk. Ilmar Laaban ; Äraneetud naised (Delphine ja Hyppolyte) / tlk. Ain Kaalep ; Vampiiri metamorfoosid / tlk. August Sang. Orig.: Les Bijoux ; Le Léthé ; A celle qui est trop gaie ; Lesbos ; Femmes damnées. Delphine et Hippolyte ; Les Métamorphoses du vampire

  16. Postcolonial heterotopias in Marek Piestrak's Estonian co-productions : a paracinematic reading / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2014-01-01

    M.Piestraki populaarsete ja "parafilmidena" käsitletavate "Navigaator Prix"(1978) ja "Madude oru needus"(1988) analüüs. Piestraki filmide ruumimaailmu uurides toetutakse Foucault' heterotoopiakontseptsioonile ja mõningatele postkolonialistku teooria mõttekäikudele

  17. Transcriptomic Analysis of Host Immune Response in the Skin of Chickens Infected with Marek's Disease Virus

    Science.gov (United States)

    Marek’s disease virus, a highly cell-associated oncogenic 'alpha-herpesvirus, is the causative agent of a T cell lymphoma and neuropathic disease called Marek’s disease. The skin is the only anatomical site where infectious enveloped cell-free virions are produced and shed into the environment. Stud...

  18. Pariisi kiri. Suvine raamatuhooaeg = A letter from Paris. Summer book season / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2010-01-01

    Prantsusmaal 1999. aasta suvel ilmunud raamatutest. Ka Ülemaailmsest Kultuuride Akadeemiast (Académie universelle des cultures) ja selle organisatsiooni korraldatud konverentsist "Mälu ja ajalugu" (Pariis, 1998)

  19. Appraisal of experimental and commercial Marek's disease vaccines to induce bursal and thymic atrophy

    Science.gov (United States)

    Recently, several experimental Marek’s disease (MD) vaccines were developed that appear to protect equally or better than the best commercial vaccines. However, some of the experimental vaccines were reported to induce transient bursal and thymic atrophies. We will report on two promising experiment...

  20. Kas sotsiaalmeedias turundamiseks tehtud investeeringu tootlust saab mõõta? Donna L. Hoffman, Marek Fodor

    Index Scriptorium Estoniae

    Hoffmann, Donna L.

    2010-01-01

    Sotsiaalmeedia vahendusel toimuva turunduse efektiivsuse mõõtmise võimalustest. Lisatud tabel : Sotsiaalmeediarakenduste olulisemad mõõdikud, süstematiseerituna võtmetähtsusega sotsiaalmeedia eesmärkide järgi

  1. Marek Zvelebil (1952-2011) a zemědělská hranice

    Czech Academy of Sciences Publication Activity Database

    Končelová, Markéta; Květina, Petr

    2011-01-01

    Roč. 63, č. 4 (2011), s. 703-707 ISSN 0323-1267 R&D Projects: GA ČR(CZ) GAP405/11/1590 Institutional research plan: CEZ:AV0Z80020508 Keywords : neolithisation * identity * hunter-gatherers Subject RIV: AC - Archeology, Anthropology, Ethnology

  2. Differential serotonergic mediation of aggression in roosters selected for resistance and susceptibility to Marek's disease

    Science.gov (United States)

    Serotonin (5-HT) is a primary regulating neurotransmitter involved in aggressive and impulsive behaviors in mammals. Previous studies have also demonstrated the function of serotonergic system in regulating aggression is affected by both genetic and environmental factors. The serotonergic system m...

  3. Las liigid kaovad, kuid ärge mu autot puutuge! / Marek Strandberg ; kommenteerinud Matti Masing

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2010-01-01

    Maa ökosüsteem on sedavõrd unikaalne ja mitmekesine, et vähemalt praegu ei suuda me arvestuste tegemisel paljusid tegureid arvesse võtta, ja nii ei olegi suudetud inimtegevuse mõju kliimale tõestada. Kuid ei ole suudetud tõestada ka vastupidist

  4. Global Conflicts and the Macro-Regional Modernities: Interview with Marek Hrubec

    Czech Academy of Sciences Publication Activity Database

    Hrubec, Marek; Solík, M.

    2015-01-01

    Roč. 6, č. 1 (2015), s. 83-98 ISSN 1338-130X Institutional support: RVO:67985955 Keywords : global conflicts * injustice * recognition * macro-regions * modernities * critical theory * intercultural Subject RIV: AJ - Letters, Mass- media , Audiovision

  5. Selection for immunoresponsiveness in chickens : effects of the major histocompatibility complex and resistance to Marek's disease

    NARCIS (Netherlands)

    Pinard, M.H.

    1992-01-01

    Improving genetic disease resistance may be an attractive preventive measure in the control of infectious diseases in livestock production. Chickens were selected for high and low antibody response to sheep red blood cells for ten generations. Divergent selection was successfully achieved

  6. Kujuteldavad maastikud : Ida-Baltikum ja 13. sajandi Euroopa kultuuriline geograafia / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2014-01-01

    Vajadusest tekstilise kaardistamise kaudu ühendada Eesti- ja Liivimaa läänekristlikus Euroopas käibiva geograafilise diskursusega ning selleks kasutatud retoorilistest ja narratiivsetest võtetest

  7. Kollaboratsionismi paradoksid : eesti kirjandus okupeeritud Prantsusmaal (1940-1944) / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2001-01-01

    Bibliogr. joonealustes märkustes. Aleksander Aspeli eesti kirjanduse tutvustustest ajalehes "Comoedia". A. H. Tammsaare romaaniepopöa "Tõde ja õigus" avaldamisest prantsuse keeles (tlk. Elisabeth Desmarest; Pariis : Pierre Trémois' kirj., 1944-1948). Artikli aluseks on ettekanne kollokviumil "Romaani kirjanduse retseptsioonist ja tõlkimisest Eestis. In memoriam Aita Kurfeldt". Tartus, 23. veebr. 2001

  8. Teekond Kirjasõna Vabariigis / Märt Väljataga ; intervjueerinud Marek Tamm

    Index Scriptorium Estoniae

    Väljataga, Märt, 1965-

    2015-01-01

    Märt Väljataga tõlgitud R. Rorty artiklist "Pragmatism ja filosoofia", mis ilmus Akadeemia 1992, nr. 2, lk. 281-282, 285, tema filosoofiast ja Märt Väljataga tööst ajakirja "Vikerkaar" toimetajana ning tõlkijana

  9. Eesti kirjandus Prantsusmaal 2002 : jälle ebaharilikult priske saak / Marek Tamm

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2003-01-01

    2002. a. ilmus prantsuse keeles neli eesti kirjandusteost: Antoine Chalvini koostatud novellivalimik "Les hirondelles" ("Pääsukesed"); Eva Koffi näidend " Meie isa" ("Notre père", tõlkija Eva Toulouze); Jaan Kaplinski tõlkekogu "Le désir de la poussière" ("Tolmu igatsus", koostaja ja tõlkija Antoine Chalvin); Karl Ristikivi "Inimese teekond" ("Chemin terrestre", tõlkija Tarah Montbélialtz, pseud.)

  10. Abraham Lincolni nähtamatud käed / Marek Tiits

    Index Scriptorium Estoniae

    Tiits, Marek

    2005-01-01

    Eesti probleem pole mitte inimeste vähene ettevõtlikkus, arvab autor, vaid majanduskeskkond, mis soosib pigem tarbimist kui ekspordile orienteeritud tegevuste arendamist. Eesti vajab Ameerika ühendamise aegset poliitikat, mille keskmes oli sotsiaalne mobiilsus ning majanduse struktuuri ajakohastamine

  11. Havipüügist hilissügisel jerklantidega / Pavel Margulis, Marek Sukk, Marko Zlatin

    Index Scriptorium Estoniae

    Margulis, Pavel

    2015-01-01

    Jerkimise kohta arvavad paljud kalastajad, et see on üks keeruline püügiviis, mida on raske õppida ning mis nõuab spetsiaalset ja kallist varustust. Oma kogemusi jagavad jergipüüdjad, kes on nende lantidega Eesti vetest muljetavaldavaid havisid välja tõmmanud

  12. Kirjandusteooria ja ajalookirjutis / Hayden White ; tõlk. Erkki Sivonen, toim. Marek Tamm

    Index Scriptorium Estoniae

    White, Hayden

    2003-01-01

    Moodsa kirjandusteooria tähtsusest ajaloo, ajalooteadvuse, ajaloodiskursuse ja ajalookirjutuste teoorias. Tõlke allikas: White, H. Figural Realism. Studies in the Mimesis Effect. Baltimore, London : The John Hopkins University Press : 1999

  13. Kirjandusteooria ja ajalookirjutis / Hayden White ; tõlk. Erkki Sivonen, toim. Marek Tamm

    Index Scriptorium Estoniae

    White, Hayden

    2003-01-01

    Moodsa kirjandusteooria tähtsusest ajaloo, ajalooteadvuse, ajaloodiskursuse ja ajalookirjutuste teoorias. White, H. Figural realism : studies in the mimesis effect. Baltimore ; London : J. Hopkins University Press : 1999

  14. The influence of major histocompatibility complex and vaccination with turkey herpesvirus on Marek's disease virus evolution

    Science.gov (United States)

    Over the last five decades, the pathogenicity of the Marek’s disease virus (MDV) has evolved from the relatively mild strains (mMDV) observed in the 1960s to the more severe very-virulent-plus strains currently observed in today’s outbreaks. The use of vaccines to control Marek’s disease (MD), but n...

  15. Turismikampaania hillitses oma reklaamiklippe / Mari Rebane

    Index Scriptorium Estoniae

    Rebane, Mari

    2005-01-01

    Turismikampaaniaks valmistatud videoklippi muudeti Eestist saadud negatiivse tagasiside tõttu. Turismikampaania teostaja OÜ Brilliant Marketing Communication partner Aivar Laan selgitab videoklippide eemaldamist kampaania kodulehelt

  16. RSM Outlook Winter 2008 : Strategy: surviving in turbulent times

    NARCIS (Netherlands)

    R. Gilbert (Russell); R. Morris (Rebecca); L. Sawahata (Lesa)

    2008-01-01

    markdownabstract#### Q&A with Carien van der Laan (Lesa Sawahata) Her CV is impressive: an early career as a corporate attorney, an MBA from Harvard Business School, and subsequent management positions for such companies as McKinsey, KPN and Versatel. It’s clear that Carien van der Laan has

  17. Norman Davies : kogu ajaloolise tõe kirjapanek pole paratamatult võimalik / Norman Davies ; interv. Marek Tamm

    Index Scriptorium Estoniae

    Davies, Norman, 1939-

    2008-01-01

    Intervjuu Läänes Ida-Euroopa ajalugu tutvustanud Briti ajaloolasega. Vt. samas: Bahovski, Erkki. Puhas ajalugu? Tartu Ülikooli aulas 8. oktoobril 2008 "Presidendi Kärajate" raames toimunud president Toomas Hendrik Ilvese ja Oxfordi ülikooli ajalooprofessori Norman Daviese avalikust kahekõnest. Vestlust juhatas Eesti suursaadik Suurbritannias Margus Laidre. Autori sõnul tahtis Eesti president rääkida tänapäeva poliitikast, N. Davies aga ajaloost

  18. Marek Lemsalu : kehv tunne, et väravat ei suutnud lüüa / Andres Kalvik, Peep Pahv

    Index Scriptorium Estoniae

    Kalvik, Andres, 1982-

    2006-01-01

    Vt. ka Postimees : na russkom jazõke 15. sept., lk. 10. Tallinna Levadia jalgpallimeeskond esitas UEFA karikasarja esimese ringi avakohtumiseks nimeka Inglise klubi Newcastle Unitedi vastu nauditava partii, kuid pidi sellegipoolest vastu võtma napi 0:1 kaotuse

  19. Marek's disease in backyard chickens, a study of pathological findings and viral loads in tumorous and non-tumorous birds

    Science.gov (United States)

    Marek’s disease (MD) is a major cause of mortality in backyard chickens. The diagnosis of MD is complex, however, and knowledge on Marek’s disease virus (MDV) in spontaneous field cases such as in backyard chickens is largely unknown. Forty backyard chickens with presumptive MD diagnosis based on hi...

  20. MHC Expression on Spleen Lymphocyte Subsets in Genetically Resistant and Susceptible Chickens Infected with Marek's Disease Virus

    DEFF Research Database (Denmark)

    Dalgaard, Tina; Bøving, Mette K.; Handberg, Kurt

    2009-01-01

    cytometry for MHC surface expression. In the spleen, constitutive MHC class I surface expression was found to be highest in homozygous B19, lowest in homozygous B21, and intermediate in heterozygous B19/B21 animals. This was observed on CD4(+), CD8(+), and Bu-1(+) splenic lymphocytes. Chickens of all three...... genotypes were subjected to infection with MD virus (GA strain) and spleen samples from infected as well as MHC-matched negative controls were analyzed at 1, 4, and 8 wk post-infection (p.i.). It was observed that MDV induced an increase in MHC class I expression late in the infection. Thus, MHC class I...... was increased on the surface of CD4(+) cells from infected chickens of all genotypes at 4 and 8 wk p.i. compared with negative controls. Also, MHC class I expression was increased on CD8(+) cells from infected chickens of all genotypes at 4 and 8 wk p.i., except for the homozygous B19 animals, that showed...

  1. Integrér les minorités russophones en Estonie / Marek Tamm ; interv. Antoine Jacob

    Index Scriptorium Estoniae

    Tamm, Marek, 1973-

    2007-01-01

    Autor kommenteerib vene vähemuse integratsiooniprobleeme Eestis, Eesti valitsuse otsust teisaldada Teise maailmasõja mälestusmärk Tõnismäelt ning pronkssõduri teisaldamisele järgnenud aprillirahutusi

  2. Meie igapäevast mürki anna meile tänapäev / Marek Strandberg

    Index Scriptorium Estoniae

    Strandberg, Marek, 1965-

    2006-01-01

    Greenpeace ja Eestimaa Looduse Fond korraldasid ohtlikest kemikaalidest teavitamise kampaania, mille käigus neljalt eestlaselt võeti analüüsimiseks verd. Autor tutvustab analüüsitulemusi ning selgitab nende ainete oletatavat päritolu oma organismis

  3. Harvesting an experiment: observations of bushy landrace winter rye in a small scale experimental slah-and-burn field in Estonia / Kersti Kihno, Liisi Jääts, Mati Laane

    Index Scriptorium Estoniae

    Kihno, Kersti, 1963-

    2015-01-01

    13. sajandi alguseks kujunes talirukis Eesti ala tähtsaimaks toiduteraviljaks ning oli 13. - 18. sajandini ka peamine ekspordiartikkel. Alepõllul kasvatatud puhmasrukis andis suuri saake, kuid oli nõudlik maa viljakuse suhtes. Eksperiment toimus Tartumaal. Eksperimendi tulemused kinnitasid ajalooallikate kirjeldusi - soodsates tingimustes on puhmasrukis väga saagikas. Kuigi väiksemõõtmelise eksperimendi tulemusi ei saa käsitleda kui suure alepõllu täpset mudelit, annab see siiski olulist materjali talirukki maasordi kohta, mis on siiani saanud teenimatult vähe tähelepanu

  4. Lugemisnoppeid / Toomas Tiivel

    Index Scriptorium Estoniae

    Tiivel, Toomas, 1952-

    2012-01-01

    Tutvustus: Tarand, Andres, Strandberg, Marek. Rahvusliku julgeoleku küsimus : Andres Tarandi ja Marek Strandbergi kriitilised kõned Eesti energeetika arengu asjus. Tallinn, 2010 ; Lauerma, Hannu. Usk, lootus ja ohtlik bluff : julgustamisest vaimse terrorini. Tallinn, 2008

  5. Georges Pereci ammendamatu kirjandus / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-

    2009-01-01

    Arvustus: Perec, Georges. Mõelda/liigitada ja teisi tekste / koostanud, [toimetanud ja järelsõna:] Marek Tamm ; prantsuse keelest tõlkinud Anti Saar, Marek Tamm, Marike Tammet. Tallinn : Varrak, 2008

  6. "Poisid on kadedad, et tüdrukud keerlevad nüüd ainult minu ümber" / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2003-01-01

    Tallinna 21. keskkoolis käivad ja Tallinna Poistekooris laulvad poisid Mark Laane, Oliver Remma ja Jörgen Aav, kes vaheldumisi mängivad-laulavad Georg Malviuse lavastatud muusikalis "Oliver Twist" peaosi

  7. Microsoft loob Eestis arenduskeskuse / Lauri Linnamäe

    Index Scriptorium Estoniae

    Linnamäe, Lauri

    2008-01-01

    Tarkvaraettevõte Microsoft rajab Eestisse arenduskeskuse, mis peaks koguma Eesti parimad e-lahendused ja tegema need kättesaadavaks Microsofti partneritele. Microsoft Eesti juhi Rain Laane, Wemedia juhi Taavi Kotka ja regionaalminister Siim-Valmar Kiisleri arvamusi

  8. CybermarketingInEstonia.ee / interv. Oksana Kostina

    Index Scriptorium Estoniae

    2005-01-01

    Vestlusringis reklaamist ja turundusest Internetis osalesid Sten Klemm, Mihkel Vabrit, Esme Kassak, Aivar Laan, Andrei Korobeinik, Üllar Tamm, Raiko Raie, Martin Orav, Priit A. Heinsalu ja Allan Sombri

  9. Jäneda viimane mõisaproua ilmus eestlase ette / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2011-01-01

    Jänedal Pulli tallis 1. juulil esietendunud Hendrik Toompere noorema lavastusest "Pärast surma Jendalis" (MTÜ R.A.A.A.M). Autor: Urmas Lennuk, osades: Merle Palmiste, Rain Simmul, Sulev Teppart, Marta Laan, Hendrik Toompere noorim

  10. Koomilised ja mahlakad külalood minevikust köidavad kõikjal nii maa- kui linnarahvast / Marek Pihlak

    Index Scriptorium Estoniae

    Pihlak, Marek, 1974-

    2009-01-01

    Erinevate külateatrite lavastustest: Aino Aarniste poolt kirjutatud ning Triin Jugapuu lavastatud loost "Pildikesi külaelust", Jaak Kõdari näitemängust "Kõik läheb mööda", Vello Jaaska kirjutatud ja Kiira Soovarese poolt lavastatud loost "Kui lõhnab maarjahein"

  11. Down-regulation of MHC Class I by the Marek's Disease Virus (MDV) UL49.5 Gene Product Mildly Affects Virulence in a Haplotype-specific Fashion

    Science.gov (United States)

    Marek’s disease is a devastating neoplastic disease of chickens caused by gallid herpesvirus 2 or Marek’s disease virus (MDV), which is characterized by massive visceral tumors, immune suppression, neurologic syndromes, and peracute deaths. It has been reported that MDV down-regulates surface expre...

  12. Eesti saab Euroopa rahaliidu 17. liikmeks / Andrus Karnau ; kommenteerinud Marek Belka, Angela Merkel, Taavi Veskimägi ja Andrus Ansip

    Index Scriptorium Estoniae

    Karnau, Andrus

    2010-01-01

    1. jaanuaril liitub Eesti euroga. Eesti majandusest. Maailmas on käimas kolm valuutasõda: Hiina jeeni ümber, maailma rikkamate riikide keskpankade ümber ja arenevate riikide valitsuste valuutainterventsioonide ümber

  13. ULTRASTRUCTURAL STUDIES ON MUSCULAR ATROPHY IN MAREK'S DISEASE : I. DENERVATION ATROPHY IN CHICKEN SKELETAL MUSCLE A LIGHT AND ELECTRON MICROSCOPIC STUDY

    OpenAIRE

    MADARAME, Hiroo; FUJIMOTO, Yutaka; MORIGUCHI, Ryozo

    1986-01-01

    When denervation was performed by nerve-cutting and nerve-crushing in chickens, three phases could be observed morphologically. The first phase was characterized by foregoing degenerative changes of the neuro-muscular junctions (axon terminals), followed by atrophic changes of the muscle fibers. The second phase was characterized by irregular arrangement of the myofilaments in atrophic muscle fibers and appearance of regenerative muscular changes by 20 days after denervation. By this time, no...

  14. Kohustiste täitmine ja tagamise vahendid : [bakalaureusetöö] / Marek Sepp ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

    Index Scriptorium Estoniae

    Sepp, Marek

    1994-01-01

    Kohustiste täitmine, nõuetekohase täitmise printsiip, vastastikune täitmine, deponeerimine, kohustiste täitmine natuuras; kohustiste täitmise tagamine (käendus, garantii, leppetrahv, käsiraha, pant)

  15. Muutumismäng 2010. 1.-5. osa / tekst Kerttu Soans ; kommenteerinud Tõnis Elling, Maiu Herzmann, Reet Martinson, Marek Sildoja, Pille Mitt, Marko Vilipson

    Index Scriptorium Estoniae

    Soans, Kerttu, 1961-

    2010-01-01

    Ajakirja Üks Muutumismäng 2010 jälgib nende käekäiku, kes soovivad langetada kaalu osaledes spordiklubi Artic Sport XL-treeningprogrammis. Tutvustatakse ka inimest, kes on eeskujuks teistele treenijatele ja kaalulangetajatele

  16. Genetic susceptibility to and presence of endogenous avian leukosis viruses impose no significant impact on survival days of chickens challenged with very virulent plus Marek's disease virus

    Science.gov (United States)

    Chicks of distinct genotypes at the tumor virus B locus (TVB) in combination with presence or absence of endogenous avian leukosis virus ev21 gene in their genomes were examined for survival day patterns after challenge with very virulent plus Marek’s disease virus (vv+MDV) in three consecutive tria...

  17. Ajaloo representatsioon ja kogemus : intervjuu Frank Ankersmitiga / Frank Ankersmit ; intervjueerinud Marek Tamm ; ingliskeelsest käsikirjast tõlkinud Märt Väljataga

    Index Scriptorium Estoniae

    Ankersmit, Frank, 1945-

    2015-01-01

    Ajaloo uurimisest ja ajalookirjutusest. Historismist. Leibnizi tähtsusest ajaloofilosoofiale. Poliitilisest filosoofiast. Ajaloo kogemusest ja mineviku mõistest. Ajaloofilosoofiast ja ajalooteooriast

  18. Estonski kulturist sõgrajet glavnuju rol v Gollivude

    Index Scriptorium Estoniae

    2008-01-01

    Portaal fitness.ee teatel ootab kulturisti Marek Kalmust roll Hollywoodis, kus Tõnis Carbek olevat stuudiole Pixar Animation esitanud stsenaariumi, mis kirjutatud M. Kalmust peaosalisena silmas pidades

  19. Kolm väärt väljapanekut Võru Linnagaleriis / Andrus Raag

    Index Scriptorium Estoniae

    Raag, Andrus, 1982-

    2009-01-01

    Helen Meleski, Katrin Teesi ja Liina Guiteri (ühisnimi Sigmund Freud) näitus "Keemia", Ruti Jõgi joonistuste ja Aivar Rumvoldi maalide näitus "Koos. Omaette", Marek Hämmelbergi (pseudonüüm Marek) joonistuste näitus "Tuvi ämm" 20. novembrini

  20. A note on existence and stability of solutions for semilinear Dirichlet ...

    Indian Academy of Sciences (India)

    (Math. Sci.) Vol. 121, No. 2, May 2011, pp. 201–215. c Indian Academy of Sciences. A note on existence and stability of solutions for semilinear. Dirichlet problems. MAREK GALEWSKI. Institute of Mathematics, Technical University of Lodz, Wolczanska 215,. 90-924 Lodz, Poland. E-mail: marek.galewski@p.lodz.pl.

  1. On existence and stability of solutions for higher order semilinear ...

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 118; Issue 4. On Existence and Stability of Solutions for Higher Order Semilinear Dirichlet Problems. Marek Galewski ... Author Affiliations. Marek Galewski1. Faculty of Mathematics and Computer Science, University of Lodz, Banacha 22, 90-238 Lodz, Poland ...

  2. Mutations within ICP4 acquired during in vitro attenuation do not alter virulence of recombinant Marek’s disease viruses in vivo

    Science.gov (United States)

    Marek's disease (MD) is a T-cell lymphoma of chickens caused by the oncogenic Marek's disease virus (MDV). MD is primarily controlled by live-attenuated vaccines generated by repeated in vitro serial passage. Previous efforts to characterize attenuated MDVs identified numerous mutations, particularl...

  3. Histoire de lÈstonie et de la nation estonienne : Eesti ja eesti rahvuse ajalugu : intervjuu Jean-Pierre Minaudier̀ga / Jean-Pierre Minaudier ; küsitlenud Marek Tamm

    Index Scriptorium Estoniae

    Minaudier, Jean-Pierre

    2008-01-01

    Intervjuu raamatu "Histoire de lÈstonie et de la nation estonienne" autori, prantsuse ajaloolase Jean-Pierre Minaudier̀ga. Raamatututvustus : Minaudier, Jean-Pierre. Histoire de lÈstonie et de la nation estonienne. Paris : L̀Harmattan, 2007 (Bibliothèque finno-ougrienne; 17)

  4. Toidutööstus panustab detsembris jõulutoodetele. Pühad toovad käibelisa / Ain Alvela, Ketlin Rauk ; kommenteerinud Ruth Roht, Marek Viilol, Simmo Kruustük, Imre Sokk

    Index Scriptorium Estoniae

    Alvela, Ain, 1967-

    2011-01-01

    Spetsiaalsed jõulutooted aitavad aasta lõpul suurendada toiduainetööstuste käivet. ASi Atria Eesti müügi- ja turundusdirektori Margus Masingu, ASi Fazer Eesti juhatuse esimehe Kristjan Kongo ja ASi Salvest turundusdirektori Ain Nõlvaku kommentaare

  5. Tööandja huvide ja õiguste kaitse töösuhetes : [bakalaureusetöö] / Marek Piiroja ; Tartu Ülikooli Õigusinstituut ; juhendaja: Heino Siigur

    Index Scriptorium Estoniae

    Piiroja, Marek

    2005-01-01

    Tööandja õiguslik staatus EV-s 1918-1939, taasiseseisvunud Eesti tööõigusest tulenevad tööandja huvide ja õiguste kaitse, sellega seonduvad probleemid, Eesti tööandjate huvide ja õiguste kaitse erinevusi võrreldes Prantsusmaa tööõiguse ja EL direktiividega

  6. Individual cybercrime offenders

    NARCIS (Netherlands)

    Weulen Kranenbarg, Marleen; van der Laan, André; de Poot, C.J.; Verhoeven, Maite; van der Wagen, Wytske; Weijters, Gijs; Leukfeldt, Rutger

    2017-01-01

    Weulen Kranenbarg, M., Laan, A. van der, Poot, C. de, Verhoeven, M., Wagen, W. van der, Weijters, G. (2017). Individual Cybercrime Offenders. In E.R. Leukfeldt (Ed.), Research Agenda: The Human Factor in Cybercrime and Cybersecurity. Den Haag: Eleven International Publishing.

  7. Off-road'i-mehed tõid Vepsamaa savist võidu koju / Merike Kungla

    Index Scriptorium Estoniae

    Kungla, Merike

    2007-01-01

    Vt. ka Linnaleht : Tartu, Linnaleht : Pärnu 28. sept., lk. B6-B7. Balti mere 4X4 karikaetapi Vepski Les masinaklassis TR1 esimese (võitja Viido Laane) ja kolmanda koha võitsid eestlased, teise koha sai lätlane

  8. Bill Gates : Miljardärist nohik / Martin Hanson

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2008-01-01

    Bill Gates loobub Microsofti juhi kohast ning jätkab vaid nõustajana. Vt. samas: Elulugu; Tasub teada; Miljardär, kes hoiab oma eraelu kiivalt saladuses. Kommenteerivad Microsoft Eesti esinduse juht Rain Laane ja IBM Eesti juht Valdo Randpere

  9. BSA : Eestis lokkab piraattarkvara kasutus / Martin Hanson

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2008-01-01

    Ilmunud ka: Delovõje Vedomosti 13. veebr. lk. 24. Piraattarkvara vastu võitleva ülemaailmse organisatsiooni BSA uuringu järgi on 52% Eestis kasutatavast tarkvarast piraattarkvara. Diagramm: Piraattarkvara levik. Kommenteerivad Rain Laane, Sulev Sisask ja riigikogu liige Hannes Astok. Ajal. Delovõje Vedomosti Hannes Astoki kommentaari asemel Andrei Sokolovi kommentaar

  10. Prof. Jaan Laanele Ellis R. Lippincott´i auhind / Henn Soonpää

    Index Scriptorium Estoniae

    Soonpää, Henn

    2005-01-01

    Ameerika Optika Ühing OSA (Optical Society of America) andis välja oma selleaastased 15 kõige väärikamat auhinda, tunnustamaks saavutusi optika ja valguskiirestuse alal. Üks auhinna vääriline on Jaan Laane, Texase A & M University in College Station keemia professor

  11. Kasvukeskkond ja andekus / Marika Veisson

    Index Scriptorium Estoniae

    Veisson, Marika, 1949-

    2001-01-01

    Imikute ja väikelastega läbi viidud longituuduuringu eesmärgiks oli välja selgitada kasvukeskkonna faktorite mõju väikelapse intellekti arengule. Töös osalesid professorid M. Vikat, V. Kolga, teadur A. Vikat, doktor E. Tomberg, magistrandid M. Laane, K. Nugin ja I. Tuisk ning V. Vallner ja A. Veber

  12. EKA magistrite mahepõld / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2010-01-01

    Eesti Kunstiakadeemia magistrantide tööde näitus "Tase 2010" SooSoo galeriis 21. juunini ning Telliskivi loomelinnaku turuhoones 10. juunini. Lähemalt Liisa Põime, Margit Kuuse, Karin Luugi, Kirsi Miettineni, Kerttu Laane, Liis Koorti töödest

  13. Uued aiaraamatud / Jaan Mettik

    Index Scriptorium Estoniae

    Mettik, Jaan

    2005-01-01

    2005. a. Tallinnas kirjastuselt "Varrak" ilmunud Mari Laane koostatud "Iluaianduse käsiraamatust" ja Clare Matthews'i raamatust "Rõdu- ja terrassililled", kirjastuselt "Tänapäev" ilmunud Ingrid Olaussoni raamatust "Hooldame aeda lihtsalt ja looduspäraselt" jt

  14. Vibrational motion in a symmetric, double minimum potential

    DEFF Research Database (Denmark)

    Spanget-Larsen, Jens

    2015-01-01

    Molecular vibrational motion in a symmetric, double minimum potential is treated by means of a quartic model potential, by reference to the tables published by Jaan Laane and the results of harmonic analyses for the stationary points. The inversion vibration of ammonia is treated in detail. - Not...

  15. Küsitavused ja tugevused kaalukausil / Lauri Vahtre

    Index Scriptorium Estoniae

    Vahtre, Lauri, 1960-

    2013-01-01

    Arvustus: Eesti ajalugu, II: Eesti keskaeg, koost ja toim Anti Selart, autorid Ivar Leimus, Kersti Markus, Anu Mänd, Inna Põltsam-Jürjo, Erki Russow, Anti Selart, Marek Tamm, Heiki Valk. Tartu: Tartu Ülikool 2012

  16. Kuidas serveerida ajaloolist arhitektuuri? : märkmeid ja märkusi "Eesti ajalugu II : Eesti keskaeg" arhitektuurilõikude kohta / Kaur Alttoa

    Index Scriptorium Estoniae

    Alttoa, Kaur, 1947-

    2013-01-01

    Arvustus: Eesti ajalugu, II: Eesti keskaeg, koost ja toim Anti Selart, autorid Ivar Leimus, Kersti Markus, Anu Mänd, Inna Põltsam-Jürjo, Erki Russow, Anti Selart, Marek Tamm, Heiki Valk. Tartu: Tartu Ülikool 2012

  17. Livestock-environment interactions: Methane emissions from ...

    African Journals Online (AJOL)

    user

    2011-02-21

    , T.1*, Wuyep, .... nogens play a key ecological role in keeping the partial pressure of hydrogen low so that fermentation ..... Ecology of methane production and hydrogen sinks in the rumen, In: Engelhardt WV, Leonhard-Marek ...

  18. Odpověď Marku Tomanovi

    Czech Academy of Sciences Publication Activity Database

    Trávníček, Jiří

    2014-01-01

    Roč. 30, č. 3 (2014), s. 5 ISSN 1211-9938 Institutional support: RVO:68378068 Keywords : Toman, Marek * Iturbe, Antonio G. * Spanish prose * literary reviews Subject RIV: AJ - Letters, Mass-media, Audiovision

  19. Slishkom genialnõi "Faust", neotrazimaja "Sonja" i torzhestvo tantsa nad slovom / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2007-01-01

    Poolas toimunud rahvusvahelise Toruni teatrifestivali "Kontakt 2007" lavastustest : Eimuntas Nekroshiuse "Faust", Petr Zelenka "Termen", Vladimir Pankovi "Ülekäik", Marek Feodori "Baal", Luc Percevali "Proovireisija surm", Alvis Hermanise "Sonja"

  20. Geenmuundatud taimed võivad vallutada maailma / Riho Laurisaar

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2005-01-01

    Eelmisel neljapäeval Tartus Briti nõukogu ja TÜ AHHAA teaduskeskuse korraldatud üritusel Café Scientifique vaidlesid Marek Strandberg ja briti biotehnoloog Ray Mathias geneetiliselt muundatud taimede ohtlikkuse üle

  1. Euroopa kohale koondusid mustad murepilved / Jeroen Bult

    Index Scriptorium Estoniae

    Bult, Jeroen

    2005-01-01

    Brüsselis toimunud Euroopa Liidu tippkohtumisel arutatud organisatsiooni eelarvearuteludest, Euroopa jagunemisest kahte leeri. Kommenteerivad Luksemburgi peaminister Jean-Claude Juncker, Prantsusmaa president Jacques Chirac ning Poola peaminister Marek Belka. Lisa: Kahes leeris euroliit

  2. [Crusading and chronicle writing on the medieval Baltic frontier: A companion to the chronicle of Henry of Livonia] / Radosław Biskup

    Index Scriptorium Estoniae

    Biskup, Radosław

    2014-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the chronicle of Henry of Livonia, eds. Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington (Vt.) : Ashgate, c2011

  3. Rahvusvaheline raamat Saaremaa vallutamisest / Raul Sulbi

    Index Scriptorium Estoniae

    Sulbi, Raul

    2007-01-01

    Arvustus: Toman, Marek. Saaremaad vallutamas : [lühijutud = The conquest of Saaremaa Island] / [illustreerinud] Jan Ungrád ; tšehhi keelest tõlkinud Leo Metsar ; ingliskeelne tekst: Mimi Rogers. Tallinn : Tiritamm, 2007

  4. 27. IV-18. V on Tallinna Matkamajas avatud...

    Index Scriptorium Estoniae

    2001-01-01

    Näitus "10 viimast aastat poola restaureerimises", millele eelnes seminar "Mälestiste kaitse ja restaureerimine Poolas". Põhiettekanne Marek Barazhskilt. Poola-Eesti restaureerimisalase koostöö jätkamisest.

  5. Koguteos ristisõdadest Läänemere idarannikul

    Index Scriptorium Estoniae

    2011-01-01

    Tutvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  6. Alguses oli Henrik / Juhan Kreem

    Index Scriptorium Estoniae

    Kreem, Juhan, 1971-

    2012-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  7. Koguteos ristisõjaliikumisest / Maiki Voore

    Index Scriptorium Estoniae

    Voore, Maiki, 1983-

    2011-01-01

    Tutvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  8. [Crusading and Chronicle Writing on the Medieval Baltic Frontier: A Companion to the Chronicle of Henry of Livonia] / Michael Amundsen

    Index Scriptorium Estoniae

    Amundsen, Michael

    2012-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham : Ashgate, 2011

  9. Mõttesügav ajalooteos / Enn Tarvel

    Index Scriptorium Estoniae

    Tarvel, Enn, 1932-

    2012-01-01

    Arvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  10. Henriku uurimise hetkeseis / Mihkel Mäesalu

    Index Scriptorium Estoniae

    Mäesalu, Mihkel, 1985-

    2011-01-01

    Tutvustus: Crusading and chronicle writing on the medieval Baltic frontier : a companion to the Chronicle of Henry of Livonia / edited by Marek Tamm, Linda Kaljundi, Carsten Selch Jensen. Farnham ; Burlington : Ashgate, 2011

  11. Arhitektura budushtshego / Boris Borissov

    Index Scriptorium Estoniae

    Borissov, Boris

    2008-01-01

    Digitaalkunsti konkurss NVArt Challenge. 2008. a. teemaks oli "Art Space :Architecture and Landscape". Esikoha sai Marek Staszek Poolast projektiga "Complex at the Centre of the Universe". 2 värvilist ill

  12. Meediareklaamiturg kasvab aasta lõpuks kuni kaheksa protsenti / Esta Kaal

    Index Scriptorium Estoniae

    Kaal, Esta, 1962-

    2002-01-01

    Emori uuring: tänu valimistele ja pensionikindlustuse reklaamikampaaniatele on oodata aasta lõpuks kuni 8%-list reklaamituru kasvu. Diagramm. Kommenteerivad Toomas Leito, Toomas Vara ja Marek Reinaas

  13. Proidi tsherez "igolnoje ushko" / Elena Rudi

    Index Scriptorium Estoniae

    Rudi, Elena

    2007-01-01

    Tallinnas avati pidulikult taastatud Trepi tänav Nõelasilma väravaga. Taastatud väravaehitist ilmestab vanast väravast säilinud barokkstiilis raidreljeef. Taastamisprojekti autor on restauraator Marek Lill

  14. Rohelised valivad enesele lõpuks esinumbri / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2011-01-01

    Roheliste erakond seab pingeritta kõik nende nimekirjas Riigikokku kandideerijad. Marek Strandbergi sõnul on see esimest korda Eesti poliitika ajaloos, kui nimekirjas kandideerivad inimesed otsustavad ka päriselt nimekirja pingerea

  15. Riigikogu pikendas eile Iraagi ja Kosovo missiooni veel aastaks / Maria-Elisa Rannajõe

    Index Scriptorium Estoniae

    Rannajõe, Maria-Elisa

    2007-01-01

    Iraagi ja Kosovo missiooni pikendamisest Riigikogus, roheliste erakonna juhi Marek Strandbergi arvamus Iraagi missiooni pikendamise kohta. ÜRO Julgeolekunõukogu pikendas liitlasvägede mandaati Iraagis aasta võrra, Iraak palus missiooni pikendamist viimast korda

  16. [Marge Rennit. Eesti muuseumid / Estonian museums] / Tapio Mäkeläinen

    Index Scriptorium Estoniae

    Mäkeläinen, Tapio

    2009-01-01

    Tutvustus: Eesti muuseumid = Estonian museums / [Eesti Muuseumiühing ; koostaja Marge Rennit ; tõlkija Tiina Mällo ; toimetaja Ivi Tammaru ; eessõna: Piret Õunapuu ; kujundaja Marek Allvee]. Tallinn : Oomen, 2008

  17. President attacks Seglins on comments / Talis Saule Archdeacon

    Index Scriptorium Estoniae

    Archdeacon, Talis Saule

    2008-01-01

    Läti president kritiseeris Läti siseministrit Mareks Seglinsit, kui viimane kasutas inglaste iseloomustamiseks ebatsensuurset väljendit, saades teada, et Läti Vabadussamba rüvetajateks olid briti kodanikud

  18. Uus kord tõi nurina / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2010-01-01

    IT-eksperdid Tõnu Samuel ja Jaan Jänesmäe peavad domeenireformi läbikukkunuks ning on koostanud avaliku kirja, milles kritiseerivad Eesti Interneti Sihtasutuse juhte Marek-Andres Kautsi ja Jaak Lippmaad

  19. Clifford Geertzi mälestusõhtu

    Index Scriptorium Estoniae

    2006-01-01

    10. novembril toimub TLÜ-s Ameerika kultuurantropoloogi Clifford Geertzi mälestusõhtu, kus esinevad rektor Rein Raud, TLÜ Eesti Humanitaarinstituudi antropoloogia keskuse dotsent Lorenzo Cañás Bottos ja kultuuriteooria lektor Marek Tamm

  20. Kultuurantropoloog Clifford Geertzi mälestusõhtu

    Index Scriptorium Estoniae

    2006-01-01

    Tallinna Ülikoolis peetakse homme Ameerika kultuurantropoloogi Clifford Geertzi mälestusõhtut, esinevad rektor Rein Raud, Eesti Humanitaarinstituudi dotsent Lorenzo Cañás Bottos ja kultuuriteooria lektor Marek Tamm

  1. Lummav antropoloog, kes vabastas etnograafia lummusest / Eeva Kesküla

    Index Scriptorium Estoniae

    Kesküla, Eeva

    2006-01-01

    Tallinna Ülikoolis 10. novembril toimunud Ameerika kultuuriantropoloogi Clifford Geertzi mälestusõhtust, kus esinesid rektor Rein Raud, Eesti Humanitaarinstituudi lektor Marek Tamm, antropoloogia keskuse dotsent Lorenzo Cañás Bottos ja Stefano Montes

  2. Seltskond / Annika Haas

    Index Scriptorium Estoniae

    Haas, Annika

    2006-01-01

    Tallinna Ülikoolis toimunud ameerika kultuurantropoloogi Clifford Geertzi mälestusõhtust, kus esinesid rektor Rein Raud, Eesti Humanitaarinstituudi dotsent Lorenzo Cañás Bottos ja kultuuriteooria lektor Marek Tamm

  3. Kui vana on su keha? / Evelin Kivilo-Paas

    Index Scriptorium Estoniae

    Kivilo-Paas, Evelin, 1979-

    2012-01-01

    Keha vanuse testimisest Polar BodyAge'i programmi abil. Treener Kristi Roosimägi analüüsib osalejate, TV3 uudisteankur Marek Lindmaa, ilmateadustaja Liis Lusmäe ja reporter Feliks Unduski tulemusi

  4. Tallinn 2011 panustab tänavu turismifirmadesse / Kärt Anvelt, Jan Jõgis-Laats ; kommenteerib Roman Geiser

    Index Scriptorium Estoniae

    Anvelt, Kärt, 1973-

    2010-01-01

    Reklaamibüroo Zavod juht Marek Reinaas annab hinnangu SA Tallinn 2011 eelarvekava turundusosale. Kommunikatsioonispetsialist Daniel Vaarik viitab võimalusele kasutada Tallinn 2011 tutvustamiseks sotsiaalvõrgustikke, nt. Facebooki ja Twitterit

  5. 26. V avati Tallinna lähistel Jõelähtme kirikus... / Margit Pärtel

    Index Scriptorium Estoniae

    Pärtel, Margit

    2004-01-01

    Näitus Saha kabelist Jõelähtme kirikus. Näitus on üles ehitatud legendidele ja 1960-ndatel toimunud restaureerimistöödele. Avamisel esinesid Marek Talts klassikalisel kitarril ja Anu Mänd viiulil

  6. 78 FR 49550 - Meetings of Humanities Panel

    Science.gov (United States)

    2013-08-14

    .... to 5:00 p.m. Location: Netherlands Organisation for Scientific Research, Laan van Nieuw Oost-Indi...: September 12, 2013. Time: 8:30 a.m. to 5:00 p.m. Location: Netherlands Organisation for Scientific Research.... 9. Date: September 13, 2013. Time: 8:30 a.m. to 5:00 p.m. Location: Netherlands Organisation for...

  7. Ühised juured: Kesk-Euroopa disain Iisraelis / Kai Lobjakas

    Index Scriptorium Estoniae

    Lobjakas, Kai, 1975-

    2012-01-01

    Näitus "Common Roots. Design Map on Central Europe" Holoni disainimuuseumis kuni 23.02.2013. Eestist esindavad nüüdisaegset disaini Sixten Heidmets / Fellin Furniture, Monika Järg, Jüri Kermik, Kerttu Laane, Jaanus Orgusaar, Kristi Paap, Villu Pruulmann, Ruumilabor, Pavel Sidorenko ja Igor Volkov. Ajaloolise disaini osas on väljas Helle Gansi, Maile Grünbergi ning Tarbeklaasi ja Estoplasti tööd

  8. [Marek Hrubec: Interkulturní dialog o lidských právech. Západní, islámské a konfuciánské perspektivy - Má smysl vést interkulturní dialog o lidských právech a proč? - Recenze a studie

    Czech Academy of Sciences Publication Activity Database

    Svoboda, Jan

    2009-01-01

    Roč. 6, č. 2 (2009), s. 164-166 ISSN 1214-4967 Institutional research plan: CEZ:AV0Z90090514 Keywords : intercultural dialogue * human rights * Western, Islamic, and Confucian perspectives Subject RIV: AA - Philosophy ; Religion

  9. Experimental Evaluation of the IP Address Space Randomisation (IASR) Technique and Its Disruption to Selected Network Services

    Science.gov (United States)

    2014-11-01

    performances de certains des services choisis au moment du changement d’adresse IP des hôtes durant l’IASR. D’après ces résultats, l’application de l’IASR à la...an operational network. Operational networks have thousands of hosts. Managing thousands of DNSs at one time is not very feasible. In addition, the...tests. In our tests, we managed to perform some file transfers without disruption. All successful cases involved the 4kB, 10MB, and 20MB files. However

  10. ERKÜ valimiste tulemused

    Index Scriptorium Estoniae

    2006-01-01

    8. aprilli koosolekul kinnitas valimiste peakomitee XIX Esinduskogu liikmed: Mati Kõiva, Ylo Anson, Juhan Simonson, Airi Vaga, Gilda M. Karu, Taavo Virkhaus, Marju Rink-Abel, Markus Vaga, Eric Suuberg, Endel Reinpõld, Jaak Juhansoo, Ülle Ederma, Lya Karm, Heino Jõgis, Kersti Linask, Jaak Rakfeldt, Erik Puskar, Jüri Linask, Viiu Vanderer, Andres Kurrik, Mati Valdek Laan, Ilmar Vanderer, Henno Uus, Jüri Tults, Urmas Wompa, Astrid Jaanson, Jüri Virkus, Lilian G. G. Bein, Tiina Harris, Tõnu Vanderer

  11. Short outlines of books by Estonian authors / Janika Kronberg and Rutt Hinrikus

    Index Scriptorium Estoniae

    Kronberg, Janika, 1963-

    2010-01-01

    Arvustus: Kiin, Sirje. Marie Under : elu, luuletaja identiteet ja teoste vastuvõtt. Tallinn : Tänapäev, 2009 ; Laanes, Eneken. Lepitamatud dialoogid : subjekt ja mälu nõukogudejärgses eesti romaanis. Tartu : Tartu Ülikooli Kirjastus, 2009 ; Ehin, Kristiina. Emapuhkus. Tallinn : Pandekt, 2009 ; Tungal, Leelo. Seltsimees laps ja suured inimesed. Tallinn : Tänapäev, 2008 ; Tungal, Leelo. Samet ja saepuru, ehk, Seltsimees laps ja kirjatähed. Tallinn : Tänapäev, 2009 ; Õnnepalu, Tõnu. Paradiis. Tallinn : Varrak, 2009

  12. Laste kehaline karistamine tuleb keelata / Raivo Juurak

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2009-01-01

    ÜRO peaassamblee on 2006. aastast alates taotlenud, et hiljemalt 2009. a. lõpuks oleks laste kehaline karistamine kõigis riikides nii koolis, karistusasutuses kui ka perekonnas täielikult keelatud. Kuidas on olukord Eestis, arutavad inimõiguste instituudi juhatuse liige Merle Haruoja, sisekaitseakadeemia kriminoloogia õppejõud Uno Traat, Lõuna politseiprefektuuri preventsioonitalituse vanemkomissar Marina Paddar, Pääsküla gümnaasiumi sotsiaalpedagoog Leena Arras, rahvusvahelise programmi "Eluväärtuste haridus" Eesti koordinaator Kalle Laane ja Audentese erakooli psühholoog Ann-Liis Ojaots

  13. TÜ ja TPÜ uusi magistreid 2002 / Tiia Margus, Hille Roots, Krista Kerge

    Index Scriptorium Estoniae

    Margus, Tiia

    2003-01-01

    TÜ eesti ja soome-ugri keeleteaduse osakonnas kaitsesid 2002.a. magistritööd N. Gordejeva, T. Leemets, S. Mäearu, M. Raadik, A. Tavast, K. Kikas, S. Iva, T. Iva, N. Kuznetsov, K. Strandson, L. Talejeva, M. Allik, V. Ernštreits, K. Kuldnokk, K. Praakli, E. Laanes, A. Pilv, K. Talviste, L. Hion, P. Noorhani, R. Hindrikus, J. Oras, L. Jääts. TPÜ eesti keele ja soome-ugri keelte magistrikraadi kaitsmisnõukogu ees kaitsesid magistritööd M. Pesti, K. Aava, J. Kallas, A. Lange, I. Kivirähk

  14. Öka-huka-filmid vallutavad lodjakino / Marju Himma

    Index Scriptorium Estoniae

    Himma, Marju

    2008-01-01

    Kinobuss ja Emajõe Lodjaselts teevad sopafilmide festivali, kus lodjakinos sees ja väljas purje peal näidatakse friikidele filme, mida suurel ekraanil vaevalt näha saab. Seekord on kavas Ilmar Raagi "Tappev Tartu" (1998), Marek Piestraki "Saatana pisar" (1993) ja sakslase Paul Wegeneri "Golem" (1920)

  15. Author Details

    African Journals Online (AJOL)

    Ibrahim, NDG. Vol 27, No 1 (2005) - Articles Toxicity studies on the methanolic extract of the leaves of cassia tora linn in mice. Abstract PDF · Vol 29, No 3 (2008) - Articles Cutaneous onchocercasis in goats slaughtered in Kaduna state, Nigeria Abstract PDF · Vol 35, No 1 (2014) - Articles Farmers' Awareness of Marek's ...

  16. Oddziaływanie lokowania produktu na postawy konsumentów. Zarys problematyki badawczej.

    Directory of Open Access Journals (Sweden)

    Ewelina Paulina Brzyszcz

    2014-07-01

    Full Text Available Lokowanie produktu to nowa forma promocji, coraz częściej wykorzystywana w różnego typu programach telewizyjnych. Celem jest nie tylko prezentowanie produktu. Lokowanie produktu działa bowiem na postawy widzów wobec marek oraz ich wybory podczas zakupów.  

  17. Untitled

    Indian Academy of Sciences (India)

    Jani SC, Marek M, Hochman R E, Meletis C I 1990 In Environment-induced fracture of metals (eds) R P Gangloff, M B Ives (Houston, TX: NACE) p. 541. Jones D A 1992 Principles and prevention of corrosion (New York; Macmillan). Jones R H 1985. In Proc. Int. Symp. Environmental Degradation of Materials in Nuclear ...

  18. 27 November 2014 - Warsaw University of Technology (PL) Vice-Rector for Research R. Bacewicz visitng the ALICE control room and undergorund experimental area with WUT students, accompanied by A. Charkiewicz and A. Siemko; joint signature ceremony with HNINP Director-General M. Jezabek

    CERN Multimedia

    Guillaume, Jeanneret

    2014-01-01

    CERN-PHOTO-201411-245-95: from left to right: Professor D.Sc.Ph.D. Rajmund Bacewicz, Vice-Rector for Research, Warsaw University of Technology, CERN Director-General R. Heuer and Prof. Marek Jeżabek, Director-General, Henryk Niewodniczanski Institute of Nuclear Physics, Republic of Poland

  19. Noormees sai Eesti Päevalehe abiga magistrikraadi / Piia Puuraid

    Index Scriptorium Estoniae

    Puuraid, Piia

    2013-01-01

    Eile sai magistrikraadi Marek Süld, kelle isa Mati Süld Eesti Päevalehest tasuta õpingud võitis. Eesti Päevaleht loosis 2010. aastal välja 13 tasuta Estonian Business Schooli bakalaureuse- või magistriprogrammi

  20. "Klass : elu pärast" võitis rahvusvahelisel festivalil peaauhinna

    Index Scriptorium Estoniae

    2009-01-01

    Genfis toimunud rahvusvahelisel festivalil Cinema Tous Ecrans sai telesarjade võistlusprogrammis peaauhinna ETV sari "Klass : elu pärast", produtsent Gerda Kordemets, stsenarist Margit Keerdo, režissöörid Ilmar Raag, Gerda Kordemets, Liina Paakspuu, Priit Valkna ja Marek Miil

  1. "Klass : elu pärast" võitis peaauhinna

    Index Scriptorium Estoniae

    2009-01-01

    Genfis toimunud rahvusvahelisel festivalil Cinema Tous Ecrans sai telesarjade võistlusprogrammis peaauhinna ETV sari "Klass : elu pärast", produtsent Gerda Kordemets, stsenarist Margit Keerdo, režissöörid Ilmar Raag, Gerda Kordemets, Liina Paakspuu, Priit Valkna ja Marek Miil

  2. Võru linnagaleriis avati kolm uut näitust

    Index Scriptorium Estoniae

    2009-01-01

    26. oktoobrist 20 novembrini on Võru Linnagaleriis avatud Ruti Jõgi joonistuste ja Aivar Rumvoldi maalide näitus "Koos. Omaette", Marek Hämmelbergi isikunäitus "Tuvi ämm" ning grupi Sigmund Freud (Liina Guiter, Katrin Tees, Helen Melesk) näitus "Keemia"

  3. .* Nigerian Veterinary Journal

    African Journals Online (AJOL)

    Farmers' Awareness of Marek's Disease and Biosecurity. Practices in Poultry Production in. Selected States of Nigeria. JWANOER, L.O.", ABOU, P.A.', IBRAHIM, N.O.G.' and NOK, J.A.'. 'Central Diagnostic, National Veterinary Research Institute Vom, Plateau State, Nigeria, 'Department of Veterinary Medicine. Ahmadu Bello ...

  4. A nine - year retrospective study of avian neoplastic diseases in ...

    African Journals Online (AJOL)

    Avian neoplastic diseases have been identified as one of the leading causes of mortality and production losses in commercial chickens in Nigeria. Although available reports described the trend of Marek's disease in Zaria, Kaduna state, they did not take cognizance of other neoplastic diseases of poultry hence the need for ...

  5. Scanforesti Purila saetööstus müüdi eksjuhile

    Index Scriptorium Estoniae

    2004-01-01

    Pankrotistunud puidutööstuse Scanforest Purila saetööstus müüdi Marek Krippeli firmale OÜ Johanna Grupp, Scanforesti vara hulka kuuluv Näpi sae- ja höövlitööstus on aga seni müümata. Nõudeid Scanforesti vastu on 81,5 miljoni krooni eest

  6. Reedel, 13. algab EMil Niidu ja Hundi medalijaht / Deivil Tserp

    Index Scriptorium Estoniae

    Tserp, Deivil, 1968-

    2007-01-01

    Alla 23-aastaste kergejõustiku EMil Ungaris Debrecenis on Eesti medalilootused sprinter Marek Niit ja kettaheitja Margus Hunt. Lisa: Eesti koondis noorsoo EMil. Vt. samas: Rene Oruman kõnnib oma kuldsetel radadel ; President Teigamägi ootab medalit

  7. Author Index

    Indian Academy of Sciences (India)

    Author Index. Aggarwal Malini see Jain Rajmal, 155. Aghaee, A. Determination of the Mean Hi Absorption of the Intergalactic. Medium, 59. Agrawal, S. P. see Singh Ambika, 89. Biesiada Marek Could the Optical Transient SCP 06F6 be due to Micro- lensing?, 213. C¸ aliskan, S . see Küçük, ˙I., 135. Evans Lloyd, T. Carbon ...

  8. Walter Benjamin ja lugemismõnu / Aija Sakova-Merivee

    Index Scriptorium Estoniae

    Sakova-Merivee, Aija, 1980-

    2014-01-01

    Arvustus: Benjamin, Walter. Lapsepõlv Berliinis 1900. aasta paiku : valik esseid. II / Walter Benjamin ; saksa keelest tõlkinud Mati Sirkel ; koostanud ja järelsõna: Marek Tamm. Tallinn : Kultuurileht, 2014. (Loomingu raamatukogu ; 2014, nr. 9/11)

  9. Author Details

    African Journals Online (AJOL)

    ... jeunesse chez deux romanciers africains froncophones: Ahmadou kourouma et boubacar boris diop, ou l'Afrique au pied du mur de la crise de la conscience Africaine Abstract · Vol 13, No 2 (2011): Series B - Articles La recriture1 des mythes bibliques dans les recits de Marek Halter et de Paolo Coelho : Reinterpretation, ...

  10. Research update: Avian Disease and Oncology Laboratory avian tumor viruses

    Science.gov (United States)

    Genomics and Immunogenetics Use of genomics to identify QTL, genes, and proteins associated with resistance to Marek’s disease. Marek’s disease (MD), a lymphoproliferative disease caused by the highly oncogenic herpesvirus Marek's disease virus (MDV), continues to be a major disease concern to the p...

  11. Rohelised mõõtsid surnud kanade temperatuuri / Vahur Koorits

    Index Scriptorium Estoniae

    Koorits, Vahur, 1981-

    2007-01-01

    Roheliste erakonda kuuluvad Riigikogu liikmed Marek Strandberg ja Mart Jüssi korraldasid Talleggi Newcastle tõve tõttu hukatud kanade matmispaigas Lagedil mõõteaktsiooni. Kaart: Kanakalmistu. Vt. samas: Strandbergi süüdistati omakasu püüdmises

  12. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 278 ... Vol 41, No 2 (2007), Taiwanese student reaction to English language internet teleconferencing for enriching EFL classroom instruction, Abstract. WV Wu, M Marek. Vol 44 .... Vol 42, No 2 (2008), The role of moderation in the National Senior Certificate examination, Abstract. W Coetzee, R Johl. Vol 38 ...

  13. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Pseudorapidity distributions of charged particles in Pb–Pb collisions at super proton synchrotron energies from the NA50 experiment. Marek Idzik M C Abreu B Alessandro C Alexa R Arnaldi M Atayan C Baglin A Baldit M Bedjidian S Beolè V Boldea P Bordalo G Borges A Bussière L Capelli C Castanier J Castor B Chaurand ...

  14. Once more on adaptation: A response to Seweryna Wysłouch

    Directory of Open Access Journals (Sweden)

    Marek Hendrykowski

    2015-11-01

    Full Text Available Marek Hendrykowski’s paper provides certain remarks and necessary explanations in response to Seweryna Wysłouch’s polemic (“A film adaptation – a translation or montage?”, published in Przestrzenie Teorii no. 22, 2014.

  15. Organizational Storytelling for Librarians: Using Stories for Effective Leadership

    Science.gov (United States)

    Marek, Kate

    2011-01-01

    Just as literature can be used for learning, the power of storytelling can be very effective when applied to leadership and management. Library expert and author Marek shows readers how they can use storytelling to communicate vision and values with: (1) A primer on how to develop storytelling skills; (2) Tips on how to use narratives to navigate…

  16. Kodukeemia hävitab meie tervist iga päev / Linda Raska

    Index Scriptorium Estoniae

    Raska, Linda

    2007-01-01

    Vt. ka Postimees : na russkom jazõke 11. okt., lk. 13. Eestimaa Looduse Fondi ja keskkonnakaitseorganisatsiooni Greenpeace eelmisel aastal korraldatud uuringul osalenud riigikogu liige ja keskkonnakaitsja Marek Strandberg tunnistab, et üritab toime tulla võimalikult vähese kodukeemiaga. Lisa: Looduslikud puhastusnipid

  17. Marek’s disease virus induced transient atrophy of cecal tonsils

    Science.gov (United States)

    Although bursal and thymic atrophy associated with Marek’s disease (MD) is well established and characterized, the effect of Marek's disease virus (MDV) infection on lymphoid aggregates within the gut-associated lymphoid tissue (GALT) is not known. The cecal tonsils (CT) are the two largest lympho...

  18. Ajalooteaduses pole absoluutset tõde olemas / Ralf R. Parve

    Index Scriptorium Estoniae

    Parve, Ralf R., 1946-2008

    2007-01-01

    4. oktoobril Tallinna Ülikoolis toimunud ümarlauast "Alternatiivsetest ajalookäsitlustest", kus ajaloo uurimise üle arutlesid ajaloolane Mart Laar, TLÜ Eesti Humanitaarinstituudi kultuuriteooria lektor Marek Tamm, TLÜ Ajaloo Instituudi direktor Magnus Ilmjärv ja TLÜ poliitikateooria professor Rein Ruutsoo. Ümarlauda juhtis rektor Rein Raud

  19. A shot from a distance. On Pierwsza piątka (The First Five by Stanisław Barańczak

    Directory of Open Access Journals (Sweden)

    Marek Hendrykowski

    2016-12-01

    Full Text Available Marek Hendrykowski’s article provides an analysis and interpretation of Barańczak’s well-known poem “Pierwsza piątka” [The First Five], whose main characters are the basketball legends of Boston Celtics, NBA champions on many occasions.

  20. Thulema ja Grand Hotel Mercure Tallinn

    Index Scriptorium Estoniae

    1999-01-01

    Peale ümberehitust avatud rahvusvahelisse hotelliketti "Accor" kuuluvast hotellist Tallinnas. Projekteerija Arhitektuuribüroo Kalle Rõõmus. Sisekujundaja Eero Jürgenson, ARS Interjöörprojekt. Valgustid klubis "Eiffel" kavandas Tõnis Vellama. Firma "Thulema" valmistatud esindusruumide mööblist. Kommenteerivad Eero Jürgenson, Allan Kompus, Kalle Rõõmus ja Marek Antoniak. 3 illustratsiooni

  1. Õudusfilmifestival oli edukas / Enriika Liiv

    Index Scriptorium Estoniae

    Liiv, Enriika

    2006-01-01

    PÖFF-i abiga (sõna võttis ka Tiina Lokk) Haapsalus toimunud õudusfilmide festival, idee autoriks reklaamiagentuuri Zavood juht Marek Reinaas. Eesti Kunstiakadeemia tudengid esinesid videoinstallatsioonide ja perfomance'ite eriprojektiga "Hirmurõõm". Näidati ka kolme eesti õudusfilmi : "Hirm", "The Undertaker", "Down Below" (režii Terje Laimets)

  2. Loskutovs' fate still in the balance

    Index Scriptorium Estoniae

    2007-01-01

    Läti seimi õiguskomisjoni juht Mareks Seglins ütles ajakirjanikele, et valitsusel polnud piisavalt andmeid otsustamaks korruptsioonitõrje büroo juhi Loskutovsi vallandamise üle. Peaminister Aigars Kalvitis tõrjus peaprokuratuuri protesti seoses korruptsioonitõrje büroo juhi Aleksejs Loskutovsi ametist vabastamisega

  3. Kas meil biosfääri kaitseala enam ei olegi? / Hans Trass, Kalevi Kull, Aleksei Lotman...[jt.

    Index Scriptorium Estoniae

    2007-01-01

    Mõjukad teadlased Hans Trass, Kalevi Kull, Aleksei Lotman, Jüri Martin, Loit Reintam ja Marek Sammul avaldavad imestust, et valitsus tunnistas kehtetuks Lääne-Eesti biosfääri kaitseala loomise, lootes samas saarestiku biosfääri uut seadustamist

  4. Keeping the European Union's foreign policy in Czech : a study of the Czech Republic's influence on the European Union's foreign policy vis-à-vis Russia and the larger post-Soviet space

    NARCIS (Netherlands)

    Neuman, Marek

    2013-01-01

    Acht jaar na de Oostelijke uitbreiding van de Europese Unie is het waardevol om te kijken naar de vraag of Tsjechië zijn plaats heeft gevonden in de instellingen van de EU en of het geleerd heeft om de EU te gebruiken als een extra laag in het maken van beleid. Marek Neuman richtte zich in zijn

  5. Police apathy on the rise / Monika Hanley

    Index Scriptorium Estoniae

    Hanley, Monika

    2008-01-01

    Läti politseinike palkade samale tasemele jätmine on muutnud nad oma töö suhtes ükskõiksemaks. Siseminister Mareks Seglins'e sõnul anti politseinikele nende palgatõusu suhtes vale informatsiooni

  6. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Arun Kumar. Articles written in Pramana – Journal of Physics. Volume 56 Issue 2-3 February-March 2001 pp 393-401 Quantum information processing. Interference due to coherence swapping · Arun Kumar Pati Marek Zukowski · More Details Abstract Fulltext PDF.

  7. Kas inimkond näeb aastat 2106? / Stephen Hawking

    Index Scriptorium Estoniae

    Hawking, Stephen W., 1942-

    2006-01-01

    Briti füüsik Stephen Hawking avas Yahoo! internetifoorumis debati, küsides foorumikasutajatelt: "Maailmas valitseb poliitiline, sotsiaalne ja ökoloogiline kaos - kuidas suudab inimkond järgmised sada aastat üle elada?". Kommenteerivad julgeolekuekspert Eerik-Niiles Kross, meditsiiniteaduste doktor Mari Järvelaid ja keskkonnaekspert Marek Strandberg

  8. Author Details

    African Journals Online (AJOL)

    Studies of some risk factors for re-introduction and spread of highly-pathogenic avian influenza in two states of Nigeria Abstract PDF · Vol 35, No 1 (2014) - Articles Farmers' Awareness of Marek's Disease and Biosecurity Practices in Poultry Production in Selected States of Nigeria Abstract PDF. ISSN: 0331-3026.

  9. Protestibiennaal kunsti suukorvistamise vastu / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2006-01-01

    Tšetšeenia toetuseks organiseeritud rahvusvahelisest rändnäitusest "Emergency Biennale" Tallinna Kunstihoones, kuraator Evelyne Jouanno. Kaasaegse Kunsti Eesti Keskuse korraldatud ettekandepäevast "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes", kus esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper, Eero Epner

  10. Journal of Astrophysics and Astronomy | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Author Affiliations. Paul D. Nuñez1 Marek Nowakowski2. Department of Physics & Astronomy, University of Utah, 115 S 1400 E, Salt Lake City, UT 84112 and Observatorio Astronómico, Universidad Sergio Arboleda, Cll. 74 No. 14–14, Bogotá, Colombia. Departamento de Física, Universidad de los Andes, ...

  11. Database of predicted SCAR markers in five fruit and three ...

    Indian Academy of Sciences (India)

    . Amazon. Genet. Mol. Res. 12. 4,. 4998–5006. Shahlaei. A.,T orabi. S.and. Khosroshahli. M.2014. Efficiacy of. SCoT and. ISSR marekers in assesment of tomato. (L ycopersicum escu- lentum. Mill.) genetic diversity. International. J. Biosciences.

  12. Extracting Information from the Gravitational Redshift of Compact ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Author Affiliations. Paul D. Nuñez1 Marek Nowakowski2. Department of Physics & Astronomy, University of Utah, 115 S 1400 E, Salt Lake City, UT 84112 and Observatorio Astronómico, Universidad Sergio Arboleda, Cll. 74 No. 14–14, Bogotá, Colombia. Departamento de Física, Universidad de los Andes, ...

  13. Metabotrobic Glutamate Receptor mGluR4 as a Novel Target for Parkinson’s Disease.

    Science.gov (United States)

    1999-10-01

    mGIu RECEPTOR AGONISTS G.J. Marek, Dept. of Psychiatry, Yale School of Medicine, New Haven, CT 06508. Serotonin (5-HT), via 5- HT2A receptors...atypical antidepressant and antipsychotic drugs block 5- HT2A receptors, group II and/or HI metabotropic agonists have a potentially promising

  14. Reformierakond naudib ülisuurt toetust / Agnes Kuus

    Index Scriptorium Estoniae

    Kuus, Agnes

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 15. mai 2007, lk. 3. Uuringufirma TSN Emor korraldatud küsitluse kohaselt oli Reformierakonna toetus pärast pronkssõduri sündmusi 46%. Diagramm: Toetus parlamendierakondadele. Kommenteerivad: Kadri Must, Marek Strandberg, Jaanus Marrandi, Margus Tsahkna, Eiki Nestor. Vt. samas: Kai Kalamees. Võimupartnerid usuvad endasse

  15. Provensálská ves a moravská města mezi středověkem a raným novověkem. Alleins 16. století v kontextu vědeckého díla Jaroslava Marka

    Czech Academy of Sciences Publication Activity Database

    Sterneck, Tomáš

    2016-01-01

    Roč. 135, č. 2 (2016), s. 421-443 ISSN 0323-052X Institutional support: RVO:67985963 Keywords : history * historians * Jaroslav Marek Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

  16. Why Do Athletes Drink Sports Drinks? A Learning Cycle to Explore the Concept of Osmosis

    Science.gov (United States)

    Carlsen, Brook; Marek, Edmund A.

    2010-01-01

    Why does an athlete reach for a sports drink after a tough game or practice? The learning cycle presented in this article helps students answer this question. Learning cycles (Marek 2009) are designed to guide students through direct experiences with a particular concept. In this article, students learn about "osmosis," or the moving of water into…

  17. An Interactive Decision Support System for Technology Transfer Pertaining to Organization and Management

    Science.gov (United States)

    1980-07-01

    similar strategy but at a much slower, less thorough and less structured manner. Artifical intelligence can improve the symbiosis of both man and...34 Management Science , June, 1978, pp. 1064-1077. Emery, F., and J. Marek, "Some Socio-Technical Aspects of Automation," in A. Rubens tein and C

  18. Tamkivi : Natura alad on ebaolulised / Ulvar Käärt

    Index Scriptorium Estoniae

    Käärt, Ulvar, 1982-

    2007-01-01

    Autori väitel on uus keskkonnaminister Jaanus Tamkivi seadnud kahtluse alla üle-euroopalise tähtsusega Natura 2000 kaitsealade vajalikkuse. Riigikogu liikme Aleksei Lotmani, Eestimaa Looduse Fondi juhatuse liikme Jüri-Ott Salmi hinnanguid. Kommenteerib Hannes Veinla. Vt. ka Aleksei Lotmani ja Marek Strandbergi kommentaare 12. apr. Meie Maa lk. 2

  19. Differential TCR Vbeta Usage in the Peripheral T Cells of Chickens Resistant and Susceptible to Marek’s Disease

    Science.gov (United States)

    Marek's disease (MD) is a herpesvirus-induced lymphoma in chickens with a significant economic impact to the poultry industry, costing the industry over $1 billion annually worldwide. MD is controllable by vaccination and improving genetic resistance in the host. Two inbred layer lines, matched at...

  20. 13.-20. IV viiakse Kütioru Avatud Ateljees läbi metsakunsti projekt

    Index Scriptorium Estoniae

    2005-01-01

    Osalevad "isekasvava arhitektuuri" (evolutionary architecture) teooria rajaja John Frazer Londonist ning Hollandi arhitektuuribürood S333 ja Onix. Käsitletakse Eesti metsade võsastumise temaatikat. 19. IV Eesti Kunstiakadeemias seminar, lisaks väliskülalistele esinevad Marek Strandberg, Ivar Puura jt.

  1. Kunstnike moraalsed valikud kultuurikonfliktides = The moral choices of artists in cultural conflicts

    Index Scriptorium Estoniae

    2006-01-01

    Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päev "Kunstnike moraalsed valikud kultuurikonfliktides" sarjast "Lisandusi eesti kunstiloole" Tallinna Kunstihoones 27.04.2006. Kava, esinevad Margit Sutrop, Johannes Saar, Andres Tali, Marek Järvik, Ene-Liis Semper ja Eero Epner, Marco Laimre. Soome filmirežissööri Pirjo Honkasalo dokumentaalfilmi "Melanhoolia kolm tuba" presentatsioon

  2. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Arun Kumar Pati. Articles written in Pramana – Journal of Physics. Volume 56 Issue 2-3 February-March 2001 pp 393-401 Quantum information processing. Interference due to coherence swapping · Arun Kumar Pati Marek Zukowski · More Details Abstract Fulltext PDF.

  3. Lavakad, 23. lend / Eva Kübar

    Index Scriptorium Estoniae

    Kübar, Eva

    2008-01-01

    Eesti Muusika- ja Teatriakadeemia lavakunstikooli XXIII lennu lõpetajatest - näitlejad Marek Tammets, Ago Soots, Agnes Aaliste, Martin Mill, Andres Oja, Juss Haasma, Maarja Mitt, Meelis Põdersoo, Jekaterina Novosjolova, Elina Pähklimägi ja Kristo Viiding, dramaturgid Marion Jõepera, Mart Kase ja Maria Lee Liivak ning lavastajad Robert Annus ja Uku Uusberg

  4. Eesti paviljon "Koda" = Estonian pavilion "Koda"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti paviljon "Koda" Hollandi maailmanäitusel "Floriade". Arhitektuurivõistlus 2011. Arhitektid Joel Kopli, Koit Ojaliiv (Kuu Arhitektid), konstruktorid Alar Hammer, Marek Suursalu (Projekt 363). Lauad Kristel Jakobson (Haka Disain), toolid Aap Piho (Maast Furniture), valgustid Margus Triibmann (Keha3)

  5. Demonstration of deterministic and high fidelity squeezing of quantum information

    DEFF Research Database (Denmark)

    Yoshikawa, J-I.; Hayashi, T-; Akiyama, T.

    2007-01-01

    By employing a recent proposal [R. Filip, P. Marek, and U.L. Andersen, Phys. Rev. A 71, 042308 (2005)] we experimentally demonstrate a universal, deterministic, and high-fidelity squeezing transformation of an optical field. It relies only on linear optics, homodyne detection, feedforward, and an...

  6. Haapsalus hakkab õudne / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    PÖFF-i abiga toimub Haapsalus õudusfilmide festival, idee autoriks reklaamiagentuuri Zavood juht Marek Reinaas. Eesti Kunstiakadeemia tudengid esinevad videoinstallatsioonide ja perfomance'ite eriprojektiga "Hirmurõõm". Lisatud festivali programmijuhi Helmut Jänese vastus ekstreemse õudusfilmi "Kannibali holokaust" näitamise kohta

  7. A globally and universally stable price adjustment process

    Energy Technology Data Exchange (ETDEWEB)

    Herings, J.J.

    1994-12-31

    Starting with Walras, economists have been interested in adjustment processes that find for a given economy and an arbitrarily specified starting price vector a Walrasian equilibrium. Mathematically, the problem is equivalent to finding a fixed point of a function under the conditions of the Brouwer Fixed Point Theorem when starting with an arbitrary initial point. In the paper it is proved that an adjustment process, originally proposed by Van der Laan and Talman, converges for almost every economy, given any starting price vector, under standard assumptions. It is possible to obtain additional results in case the excess demand function satisfies the condition of gross substitutability. In this special case it can be shown that the qualitative behaviour of the process is similar to the one of the well-known Walrasian tatonnement process. Since there is a close relationship between the existence of always converging adjustment processes and the Brouwer Fixed Point Theorem it is not a surprise that there is a relation between adjustment processes and simplicial pivoting algorithms to compute fixed points. The adjustment process considered in this paper is related to a variable dimension fixed point algorithm of Doup, Van der Laan, and Talman. The path generated by the adjustment process can be followed arbitrarily close by their algorithm. Therefore the paper also yields a contribution to the understanding of the limit behaviour of simplicial pivoting algorithms.

  8. Editor's note

    Science.gov (United States)

    2005-11-01

    Nordita, the Nordic Institute for Theoretical Physics, was founded in 1957 by Niels Bohr and Torsten Gustafsson at Blegdamsvej in Copenhagen, joint to Bohr's legendary Institute. Today, memories of Bohr and his famous visitors -- Albert Einstein, Werner Heisenberg, Lev Landau and many others -- strongly contribute to Nordita's genius loci and inspire next generations of her visitors. Nordita awards ``Nordic Project'' grants to individual Nordic physicists to help conduct a world-class research in Nordic countries (Denmark, Finland, Island, Norway, and Sweden). Research reported here was generously supported by the Nordic Project "Quasi Periodic Oscillations in Black Hole and Neutron Star sources" awarded in 2005 to Marek Abramowicz. The Project supported the ``Nordita Workdays on QPO" (March 25 -- April 1, 2005) organized by Marek Abramowicz, Axel Brandenburg and Juri Poutanen with help of Hanne Bergen, Helle http://www.nordita.dk/positions/norproject.html

  9. Quantum gravity unification via transfinite arithmetic and geometrical averaging

    International Nuclear Information System (INIS)

    El Naschie, M.S.

    2008-01-01

    In E-Infinity theory, we have not only infinitely many dimensions but also infinitely many fundamental forces. However, due to the hierarchical structure of ε (∞) spacetime we have a finite expectation number for its dimensionality and likewise a finite expectation number for the corresponding interactions. Starting from the preceding fundamental principles and using the experimental findings as well as the theoretical value of the coupling constants of the electroweak and the strong forces we present an extremely simple averaging procedure for determining the quantum gravity unification coupling constant with and without super symmetry. The work draws heavily on previous results, in particular a paper, by the Slovian Prof. Marek-Crnjac [Marek-Crnjac L. On the unification of all fundamental forces in a fundamentally fuzzy Cantorian ε (∞) manifold and high energy physics. Chaos, Solitons and Fractals 2004;4:657-68

  10. Application of memory techniques to primary school instruction

    OpenAIRE

    Pok, Marek

    2017-01-01

    Marek Pok Dissertation Abstract Application of memory techniques to primary school instruction The theoretical part is focused on effective teaching methods to primary school instruction. There have been chosen styles, methods and strategies, which are suitable for using memory techniques. Attention is paid to the memory function of students (secondary school age), who become a part of the empirical research. The theoretical part will present the concept of teaching, learning styles, methods ...

  11. Compositional differences in soybeans on the market: Glyphosate accumulates in Roundup Ready GM soybeans

    OpenAIRE

    Bøhn, T.; Cuhra, M.; Traavik, T.; Sanden, M.; Fagan, J.; Primicerio, R.

    2014-01-01

    This article is part of Marek Cuhra's doctoral thesis which is available in Munin at http://hdl.handle.net/10037/7869 This article describes the nutrient and elemental composition, including residues of herbicides and pesticides, of 31 soybean batches from Iowa, USA. The soy samples were grouped into three different categories: (i) genetically modified, glyphosate-tolerant soy (GM-soy); (ii) unmodified soy cultivated using a conventional ‘‘chemical’’ cultivation regime; and (iii) unmodifie...

  12. Eesti mehe välimääraja / Jaana Nõu, Siret Liivamägi, Katrin Õun, Silja Kalda ; intervjueerinud Tiina Kruus

    Index Scriptorium Estoniae

    2011-01-01

    Jaana Nõu, Siret Liivamägi, Katrin Õun ja Silja Kalda otsustavad nelja mehe foto põhjal nende ameti, hobide ja vanuse üle. Meesteks on anestesioloogia ja intensiivravi resident Arie Passov, Rocca al Mare kooli geograafia, ajaloo ja riigikaitse õpetaja Marek Nisuma, Põhja-Eesti päästekeskuse Lilleküla keskkomando päästja Martin Ringo ja Tallinna Ülikooli Rahvusvaheliste ja Sotsiaaluuringute Instituudi teadur Marti Taru

  13. Tänukiri

    Index Scriptorium Estoniae

    2000-01-01

    Tulemusliku töö eest tänukirjaga autasustatud TPÜ töötajad ja külalislektorid: Angela Arraste, Cécile Eliziere, Margus Harak, Aili Kants, Edgar Karofeld, Aili Kelam, Wolf Peter Klein, Jüri Kruusvall, Marek Kuzmin, Viivi Maanso, Avo Petrauts, Anne Rooste, Helve Siivo, Leida Talts, Aili Tamm, Anu Toots, Ülo Ugaste, Urve Väljas, Paul Ruudi / allikas : TPÜ rektori käskkiri, 13. oktoober 2000

  14. Investigating the Impacts of Particle Size and Wind Speed on Brownout

    Science.gov (United States)

    2015-03-26

    oversimplifying the physics of scattering, reflection, and absorption. Marek (2009) developed a technique to measure optical properties of brownout clouds...size simulated. 47 References Allen, D.J., Kasibhatla, P., Thompson, A.M., Rood , R.B., Doddridge, B.G., Pickering, K.E., Hudson, R.D., Lin, S., 1996...Desert Dunes, Methuen and Co. Ltd. Chin, M., Rood , R.B, Lin, S., Muller, J., Thompson, A.M., 2000: Atmospheric sulfur cycle simulated in the global

  15. "Navigaator Prix" - 30 aastat hiljem / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2008-01-01

    Haapsalu õudusfilmide festivalile HÕFF on kutsutud poola režissöör Marek Piestrak, kes lavastas Stanislaw Lemi teose järgi Poola ja Tallinnfilmi ühistööna ulmefilmi "Navigaator Prix" (1978). Filmimuusika lõi Arvo Pärt, kandvas osas mängis kaasa Tõnu Saar. Lisatud andmeid režissööri kohta

  16. Tuumaenergiat tuleb Eestil oodata veel aastakümneid / Endel Lippmaa ; interv. Tanel Raig

    Index Scriptorium Estoniae

    Lippmaa, Endel, 1930-2015

    2008-01-01

    Akadeemiku arvates põhineb Eesti energiatootmine järgmised 25 aastat jätkuvalt põlevkivitööstusel, tuuleenergia ja hüdroenergia osa jäävad väikeseks, tuumaenergiat hakatakse arendama tulevikus. Diagramm: Põhiosa elektrienergiast tuleb soojuselektrijaamadelt. Lisa: Eesti energiamajanduse rahuldamise vahendid. Kommenteerib Riigikogu liige Marek Strandberg: talumaja peab muutuma oma energiavarustuselt sõltumatuks

  17. A note on existence and stability of solutions for semilinear Dirichlet ...

    Indian Academy of Sciences (India)

    R → R are Caratheodory functions; Fk and Gk are continuously differentiable in x for. a.e. t ∈ [0,π]; ... x are locally Lipschitz in x uniformly in t ∈ [0,π] and k = 0, 1, 2. .... 204. Marek Galewski. Now we describe what we mean by the weak solution. Let βk > 0. Function u ∈. H2. 0 (0,π) is a weak solution to (3.1) if for any h ∈ H2.

  18. The Era of Global Disputes and Mass Media Distortions. Dialogue on Recognition, Justice and Democracy

    Czech Academy of Sciences Publication Activity Database

    Bittar, E.; Hrubec, Marek

    2017-01-01

    Roč. 8, č. 2 (2017), s. 146-154 ISSN 1338-130X Grant - others:AV ČR(CZ) StrategieAV21/15 Program:StrategieAV Institutional support: RVO:67985955 Keywords : global conflicts * international law * justice * mass media * recognition * democracy Subject RIV: AA - Philosophy ; Religion OBOR OECD: Political science https://www.communicationtoday.sk/era-global-disputes-mass- media -distortions-dialogue-recognition-justice-democracy-interview-marek-hrubec/

  19. Investigations of environmental conditions during cluster indicate probable vectors of unknown exogenous agent(s) of multiple sclerosis.

    Science.gov (United States)

    McStreet, G H; Elkunk, R B; Latiwonk, Q I

    1992-01-01

    During the tail-end of an active cluster several environmental investigations indicated that wildbirds were very probably the vectors of the unknown exogenous agent of MS. Canine distemper and genetic-autoimmune theories were very definitely eliminated because of the unusual pattern of the cluster. Studies of several avian pathogens unveiled Marek's (MDV) and/or IBD (Gumboro) as the most likely candidates for exogenous agent of MS.

  20. Kuidas üheskoos ajalugu mäletada? / Taavi Arus

    Index Scriptorium Estoniae

    Arus, Taavi

    2007-01-01

    Tallinna Ülikoolis 26. ja 27. juulil toimuvast loengusarjast, kus astuvad loengutega üles ajaloolased Peter Burke, Leonidas Donskis ja Maurice Bloch. Tallinna Ülikooli rektori professor Rein Raua sõnul on nimetatud loengusari üks selle suve intellektuaalseid kõrghetki. Loengutele järgnevad arutelud, mida juhivad vastavalt Tallinna Ülikooli Eesti Humanitaarinstituudi lektor Marek Tamm, filosoofiaprofessor Tõnu Viik ning antropoloogiadotsent Lorenzo Canas

  1. Eestlaste arvutikeemia säästab miljoneid dollareid = Estonians' computational chemistry could save millions of dollars / Madli Kents

    Index Scriptorium Estoniae

    Kents, Madli

    2006-01-01

    Vt. ka Life in Estonia 2006/Spring, lk. 40-41. Keemik Mati Karelson on viimased 15 aastat tegelnud keemiliste ühendite omaduste ennustamisega arvuti abil. Koostöös Florida ülikooli teadlaste ja oma endiste tudengitega valmis arvutiprogramm Codessa, mis võimaldab eri keemiatoodete, sh ka ravimite testimiseks ja väljatöötamiseks kuluvat aega mitu korda vähendada. Kommenteerib Marek Strandberg

  2. Disease eradication on large industrial farms.

    Science.gov (United States)

    Rozins, Carly; Day, Troy

    2016-10-01

    Many modern farms exhibit all-in-all-out dynamics in which entire cohorts of livestock are removed from a farm before a new cohort is introduced. This industrialization has enabled diseases to spread rapidly within farms. Here we look at one such example, Marek's disease. Marek's disease is an economically important disease of poultry. The disease is transmitted indirectly, enabling the spread of disease between cohorts of chickens who have never come into physical contact. We develop a model which allows us to track the transmission of disease within a barn and between subsequent cohorts of chickens occupying the barn. It is described by a system of impulsive differential equations. We determine the conditions that lead to disease eradication. For a given level of transmission we find that disease eradication is possible if the cohort length is short enough and/or the cohort size is small enough. Marek's disease can also be eradicated from a farm if the cleaning effort between cohorts is large enough. Importantly complete cleaning is not required for eradication and the threshold cleaning effort needed declines as both cohort duration and size decrease.

  3. Female Sexual Arousal Disorders

    DEFF Research Database (Denmark)

    Giraldi, Annamaria; Rellini, Alessandra H; Pfaus, James

    2012-01-01

    and psychological disorders, as well as to discuss different medical and psychological assessment and treatment modalities. Methods.  The experts of the International Society for Sexual Medicine's Standard Committee convened to provide a survey using relevant databases, journal articles, and own clinical experience....... Conclusion.  Recommendations are given for assessment and treatment of FSAD and PGAD. Giraldi A, Rellini AH, Pfaus J, and Laan E. Female sexual arousal disorders. J Sex Med **;**:**-**.......Introduction.  Definitions and terminology for female sexual arousal disorder (FSAD) are currently being debated. While some authors have suggested that FSAD is more a subjective response rather than a genital response, others have suggested that desire and arousal disorders should be combined...

  4. ANÁLISE DO RETORNO DOS INVESTIMENTOS SOCIOAMBIENTAIS DAS EMPRESAS BRASILEIRAS

    Directory of Open Access Journals (Sweden)

    Verônica Ines Fernandez Orellano

    2011-08-01

    Full Text Available This paper investigates the correlation between firm’s financial and social/environmental performance for Brazilian companies from 2001 to 2007, based on two types of panel data econometric models, which aim to analyze correlation and causality. The fixed effects model was used to estimate correlation, while a panel data IV model was used to investigate causality. The results show a positive correlation between corporate social/environmental and financial performance, mainly in the case of internal social investment, which is strongly positively correlated with the variable return on assets (ROA. The causality analysis also showed that the internal social investment has a positive and significant effect on ROA. This result is in accordance with those obtained by Laan et al (2008, which indicate that disregarding the wishes of the primary stakeholders (employees, consumers and investors contributes negatively to performance measures

  5. Editorial to: Six papers on Dynamic Statistical Models

    DEFF Research Database (Denmark)

    2014-01-01

    statistical methodology and theory for large and complex data sets that included biostatisticians and mathematical statisticians from three faculties at the University of Copenhagen. The satellite meeting took place August 17–19, 2011. Its purpose was to bring together researchers in statistics and related...... Group-Sequential Covariate-Adjusted Randomized Clinical Trials Antoine Chambaz and Mark J. van der Laan Estimation of Causal Odds of Concordance using the Aalen Additive Model Torben Martinussen and Christian Bressen Pipper We would like to acknowledge the financial support from the University...... of Copenhagen Program of Excellence and Elsevier. We would also like to thank the authors for contributing interesting papers, the referees for their helpful reports, and the present and previous editors of SJS for their support of the publication of the papers from the satellite meeting....

  6. Mis tuleb

    Index Scriptorium Estoniae

    2006-01-01

    4. veebruarist Kuressaare kultuurikeskuses Lapimooride klubi lapitööde näitus. Kuni 12. II Harjumaa Muuseumis Elgi Treimuthi portreede ja lillemaalide näitus. 12. II algab Tallinnas Nõmme kultuurikeskuses kursus "Kolm aiastiili", juhatab Mati Laane. Iisaku muuseumis näitus "Toolid maakodus". Pärnu Uue Kunsti Muuseumis 20. veebruarist näitus Heino Lillepuu kollaazhidest "Eestlased aegade keerises", kuni 24. II Edgar Valteri maalide näitus, 26. veebruarist Soome kunstnike ühenduse Unite maali-, graafika ja skulptuurinäitus. Kuni 26. II saab Eesti Rahva Muuseumis tutvuda uue muuseumihoone parimate projektidega. 26. II Nõmme kultuurikeskuses MTÜ Eesti Aiaklubi teematund Rododendron", külla tuleb Mart Lepp. Kuni 26. II Tallinna Lastemuuseumis Põlva käsitöömeistri Maaja Kalle näitus "Värvilised muinaslood", eksponeeritud nõelviltimistehnikas lauanukud, päkapikud ja waldorfnukud

  7. Riigi teaduspreemiate 2003 kandidaadid / Villi Ehatamm

    Index Scriptorium Estoniae

    Ehatamm, Villi

    2003-01-01

    2003. a. teaduspreemia kandidaadid: J. Einasto, A.-E. Kaasik, R. Hagelberg, H. Rätsep, R. Pullat, M. Kilp, V. Laan, P. Normak, S. Keevallik, V. Hižnjakov, M. Selg, T. Pehk, T. Rang, M. Mihkla, A. Eek, E. Meister, H.-J. Kaalep, J. Harro, A. Metspalu, T. Jürimäe, J. Haberman, A. Miidel, T. Nõges, E. Pihu, A. Raukas, R. Gross, T. Paaver, A. Valdmann, Ü. Tamm, M. Mandre, K. Ots, H. Pärn, J. Klõseiko, T. Rajasalu, V. Vensel, E. Berg, J. Reiljan, U. Varblane, K. Katus, A. Puur, A. Põldma, K. Rebane, M. Hallik, M. Must, A. Univere, E. Juhkam, I. Käsi, V. Lonn, E. Niit, K. Kirme

  8. Uus Eesti disain / Silvia Pärmann

    Index Scriptorium Estoniae

    Pärmann, Silvia

    2016-01-01

    Allan Prooso, Argo Männiku ja Kalmer Alliku (HOOG) disainitud riiulid. Liis Lindmaa ja Anatoli Tafitšuki disainitud kassimaja Juno. Anni Varmi puidust lõikelauad, Toivo Raidmetsa tool Arike, Maria Kalmu vineerist prossid, Jaanus Orgusaare kapp Rolling. Merili Sule ja Petrica Artene (StenCilit) disainitud seinašabloonid. Merlin Tiiveli (NION design) käsitsi valmistatud sisustuaksessuaarid (korvid, vaibad, kott-toolid). Margus Triibmanni toolvalgusti Cranberry, Stella Soomlaisi naturaalsest nahast käekotid. Kristjan Rabi, Janno Roodi, Veljo Viikanti (Aegaon) disainitud käekellad. Mari Saani, Mariana Laane (stuudio Nüüd) keraamika. Silver Tibbingi pakendikujundused Sõsara kosmeetikatoodetele, Elena Volki ja Eveliis Salaka Helge Kodu ruumiparfüümid. Kerly Kaljuste ja Anu Rajamäe (KOOSdisain) kodutekstiilid. Meelis Undi ja Mari Otsa (WolfBerry) lastemööbel

  9. Kinetics of Slurry Phase Fischer-Tropsch Synthesis

    International Nuclear Information System (INIS)

    Dragomir B. Bukur; Gilbert F. Froment; Tomasz Olewski; Lech Nowicki; Madhav Nayapati

    2006-01-01

    The overall objective of this project is to develop a comprehensive kinetic model for slurry-phase Fischer-Tropsch synthesis (FTS) employing iron-based catalysts. This model will be validated with experimental data obtained in a stirred-tank slurry reactor (STSR) over a wide range of process conditions. Three STSR tests of the Ruhrchemie LP 33/81 catalyst were conducted to collect data on catalyst activity and selectivity under 25 different sets of process conditions. The observed decrease in 1-olefin content and increase in 2-olefin and n-paraffin contents with the increase in conversion are consistent with a concept that 1-olefins participate in secondary reactions (e.g. 1-olefin hydrogenation, isomerization and readsorption), whereas 2-olefins and n-paraffins are formed in these reactions. Carbon number product distribution showed an increase in chain growth probability with increase in chain length. Vapor-liquid equilibrium calculations were made to check validity of the assumption that the gas and liquid phases are in equilibrium during FTS in the STSR. Calculated vapor phase compositions were in excellent agreement with experimental values from the STSR under reaction conditions. Discrepancies between the calculated and experimental values for the liquid-phase composition (for some of the experimental data) are ascribed to experimental errors in the amount of wax collected from the reactor, and the relative amounts of hydrocarbon wax and Durasyn 164 oil (start-up fluid) in the liquid samples. Kinetic parameters of four kinetic models (Lox and Froment, 1993b; Yang et al., 2003; Van der Laan and Beenackers, 1998, 1999; and an extended kinetic model of Van der Laan and Beenackers) were estimated from experimental data in the STSR tests. Two of these kinetic models (Lox and Froment, 1993b; Yang et al., 2003) can predict a complete product distribution (inorganic species and hydrocarbons), whereas the kinetic model of Van der Laan and Beenackers (1998, 1999) can

  10. Kinetics of Slurry Phase Fischer-Tropsch Synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Dragomir B. Bukur; Gilbert F. Froment; Tomasz Olewski; Lech Nowicki; Madhav Nayapati

    2006-12-31

    The overall objective of this project is to develop a comprehensive kinetic model for slurry-phase Fischer-Tropsch synthesis (FTS) employing iron-based catalysts. This model will be validated with experimental data obtained in a stirred-tank slurry reactor (STSR) over a wide range of process conditions. Three STSR tests of the Ruhrchemie LP 33/81 catalyst were conducted to collect data on catalyst activity and selectivity under 25 different sets of process conditions. The observed decrease in 1-olefin content and increase in 2-olefin and n-paraffin contents with the increase in conversion are consistent with a concept that 1-olefins participate in secondary reactions (e.g. 1-olefin hydrogenation, isomerization and readsorption), whereas 2-olefins and n-paraffins are formed in these reactions. Carbon number product distribution showed an increase in chain growth probability with increase in chain length. Vapor-liquid equilibrium calculations were made to check validity of the assumption that the gas and liquid phases are in equilibrium during FTS in the STSR. Calculated vapor phase compositions were in excellent agreement with experimental values from the STSR under reaction conditions. Discrepancies between the calculated and experimental values for the liquid-phase composition (for some of the experimental data) are ascribed to experimental errors in the amount of wax collected from the reactor, and the relative amounts of hydrocarbon wax and Durasyn 164 oil (start-up fluid) in the liquid samples. Kinetic parameters of four kinetic models (Lox and Froment, 1993b; Yang et al., 2003; Van der Laan and Beenackers, 1998, 1999; and an extended kinetic model of Van der Laan and Beenackers) were estimated from experimental data in the STSR tests. Two of these kinetic models (Lox and Froment, 1993b; Yang et al., 2003) can predict a complete product distribution (inorganic species and hydrocarbons), whereas the kinetic model of Van der Laan and Beenackers (1998, 1999) can

  11. Colloid and surface chemistry a laboratory guide for exploration of the nano world

    CERN Document Server

    Bucak, Seyda

    2013-01-01

    Scientific Research The research processEthics in Science Design of Experiments Fundamentals of Scientific Computing, Nihat Baysal Recording Data: Keeping a Good Notebook Presenting Data: Writing a Laboratory ReportReferencesCharacterization Techniques Surface Tension Measurements, Seyda BucakViscosity/Rheological Measurements, Patrick UnderhillElectrokinetic Techniques, Marek KosmulskiDiffraction (XRD), Deniz RendeScattering, Ulf OlssonMicroscopy, Cem Levent Altan and Nico A.J.M. SommerdijkColloids and Surfaces Experiment 1: SedimentationExperiment 2: Determination of Critical Micelle Concent

  12. Browse Author Index

    African Journals Online (AJOL)

    A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All. S. Srividya, S · Sriwongchai, Salinee · Sriyapai, Thayat · Ssemakula, G · Stahl, GL · Stajić, S · Stajnko, D · Stalin, C · Stalin, T · Stamatin, L · Stancheva, GI · Standardi, Alvaro · Stanisavljević, R · Stanisz, Marek · Stanišić, N · Stankovic, D · Stankovic, M · Stankovic, S

  13. The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence.

    Directory of Open Access Journals (Sweden)

    Mike Boots

    2015-08-01

    Full Text Available There is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide resistance, but recent theory suggests disease interventions such as vaccination may lead to evolution of more harmful parasites. A new study published in PLOS Biology by Andrew Read and colleagues shows empirically that vaccination against Marek's disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. This is an elegant empirical demonstration of how evolutionary theory can predict potentially dangerous responses of infectious disease to human interventions.

  14. On the number of elementary particles in a resolution dependent fractal spacetime

    International Nuclear Information System (INIS)

    He Jihuan

    2007-01-01

    We reconsider the fundamental question regarding the number of elementary particles in a minimally extended standard model. The main conclusion is that since the dimension of E-infinity spacetime is resolution dependent, then the number of elementary particles is also resolution dependent. For D = 10 of superstrings, D = 11 of M theory and D = 12 of F theory one finds N(SM) equal to (6)(10) = 60 (6)(11) = 66 and (6)(12) = 72 particles, respectively. This is in perfect agreement with prediction made previously by Mohamed Saladin El-Naschie and Marek-Crnjac

  15. Meil vedas! / Oliver Rand

    Index Scriptorium Estoniae

    Rand, Oliver, 1971-

    2007-01-01

    Bagdadis toimunud raketirünnakus sõjaväebaasile kukkusid raketid Eesti sõduritest ja rahvusringhäälingu võttegrupist umbes kilomeetri kaugusele. Vt. samas: Lauri Birkan. Kas Eesti peaks sõdurid Iraagist ära tooma? vastavad Ain Seppik, Igor Gräzin, Marek Strandberg, Mart Nutt, Eiki Nestor, Karel Rüütli. Hääled rahva seast: Linnar Priimägi ja Katrin Karisma. Kaart: Pommitamine Bagdadis; Liitlasväed Iraagis

  16. Presidents' green rhetoric at U.N. questioned / Joel Alas

    Index Scriptorium Estoniae

    Alas, Joel

    2007-01-01

    President Toomas Hendrik Ilves kõneles 24. septembril 2007 ÜRO peakorteris toimunud kliimakonverentsil, tehes seda Euroopa Liidu eesistujamaa Portugali palvel kogu Euroopa Liidu nimel. Erakonna Eestimaa Rohelised liider Marek Strandberg seab kahtluse alla mõnede president T.H. Ilvese poolt esitatud väidete paikapidavuse. Leedu presidendi Valdas Adamkuse ja Läti presidendi Valdis Zatlersi poolt väljendatud seisukohtadest. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  17. The entrance of youth with low education into the labour market in Latvia

    OpenAIRE

    Mareks Niklass

    2013-01-01

    Annotation The title of the dissertation: The entrance of youth with low education into the labour market in Latvia The author of the dissertation: Mg.soc. Mareks Niklass The supervisor of the dissertation: prof. Dr.soc. Aivars Tabuns The objective of the dissertation is to identify the factors that inhibit or facilitate the entrance of youth with low education into the labour market in Latvia as well as to verify the validity of a number of theories such as the theory of...

  18. Joint Services Electronics Program

    Science.gov (United States)

    1982-09-30

    McNamee (eds.), Englewood Cliffs, New Jersey: Prentice- Hall, Inc., 1976. 3. Kaplan , "Computer-Aided Design," IEEE Snectrum, October 1975. M. J...A. L Tits newton methods for inequality constrained optinization prcbier_.s." M.. Marek-Sadowska Ma1 /95 "A new approach to channel E. S. Kuh routing...linear distributed feedback systems." V. Visvanathan MB1/45 "Fault diagnosis of nonlinear circuits and systems: Part I-the DC case." W. T. Nye Ma1 /19

  19. Why is Helfenstein's claim about equichordal points false?

    OpenAIRE

    Rychlik, Marek

    2012-01-01

    This article explains why a paper by Heinz G. Helfenstein entitled "Ovals with equichordal points", published in J.London Math.Soc.31, 54-57, 1956, is incorrect. We point out a computational error which renders his conclusions invalid. More importantly, we explain that the method cannot be used to solve the equichordal point problem with the method presented there. Today, there is a solution to the problem: Marek R. Rychlik, "A complete solution to the equichordal point problem of Fujiwara, B...

  20. Vägivald ja propaganda

    Index Scriptorium Estoniae

    2006-01-01

    8. IV-28. V Tallinna Kunstihoones Elin Kardi, Marco Laimre, Marko Mäetamme ja Andres Tali näitus "Vägivald ja propaganda". 26. IV-7. V näituse raames emergency biennale, rahvusvaheline rändnäitus Tšetšeenia toetuseks. 27. IV Kaasaegse Kunsti Eesti Keskuse IV ettekannete päev "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes". Esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper & Eero Epner ning näitusel "Vägivald ja propaganda" osalevad kunstnikud

  1. INFLUENCIA DE UNA VACUNA VECTORIZADA (MAREKGUMBORO) EN POLLOS DE LA LÍNEA GENÉTICA COBB 500

    OpenAIRE

    Fátima Graciela Arteaga Chávez; Gabriela Natalí Narváez Borja; Zoyla Estefany Sánchez Santana

    2013-01-01

    El presente trabajo tuvo como objetivo evaluar el efecto de una vacuna vectorizada (Marek - Gumboro) en pollos COBB 500. Se utilizaron 1300 pollitos con pesos promedio al nacer de 43 g los cuales se dividieron en dos grupos, el primero con 625 pollitos BB se aplicó la vacuna vectorizada y el segundo, con 675 pollitos BB, se aplicó la vacuna tradicional. Como indicado- res productivos se midió peso vivo semanal, peso a la canal y conversión alimenticia; para los indicadores de salud e inocuida...

  2. Finding the Walls of Troy: Frank Calvert and Heinrich Schliemann at Hisarlik. Susan Heuck Allen. Uni­versity of California Press, Berkeley, 1999

    Directory of Open Access Journals (Sweden)

    Andrew L. Christenson

    2000-05-01

    Full Text Available As a teenager my parents received through the Book-of-the-Month Club a volume that could easily have led me to want to become an archaeologist if I had not already made that decision. Gods, Graves. and Scholars by C. W. Cerarn (pseudonym of German journalist Kurt W. Marek had been first published in Germany in 1949 and translated and published in the U.S. in 1951 (Ceram 1951. This book, still in print, was one of the few written in the first half of the century to bring the history of archaeology to a general audience.

  3. T-cell lymphoma in a wild Okinawa rail (Gallirallus okinawae).

    Science.gov (United States)

    Neagari, Yasuko; Nagamine, Takashi; Nakaya, Yumiko; Onuma, Manabu; Murata, Koichi; Kuwana, Takashi

    2011-03-01

    The Okinawa rail (Gallirallus okinawae) is an endangered species that inhabits the northern part of Okinawa Main Island in southern Japan. A wild Okinawa rail was rescued from a road in Kunigami Village in Okinawa in October 2009. The bird subsequently died and underwent necropsy. Tumors were found in the liver, spleen and part of the small intestine. Microscopically, lymphoid neoplasm was confirmed in these tissues. The tumor cells were mainly positive for CD3 and CD8α by immunohistochemistry. No Marek's disease virus genes were detected by PCR of a liver tumor. This is the first report of T-cell lymphoma in the Okinawa rail.

  4. Diverse uses of feathers with emphasis on diagnosis of avian viral infections and vaccine virus monitoring

    Directory of Open Access Journals (Sweden)

    I Davidson

    2009-09-01

    Full Text Available The large amounts of feathers produced by the poultry industry, that is considered as a waste was explored for possible uses in various industries, such as meals for animals, biofuels, biodegradable plastic materials, combating water pollution and more. That review mentions these uses, but concentrate on the utilization of feathers for the diagnosis of viral infections and for monitoring vaccine viruses in chickens after vaccination. The viral diseases in which diagnosis using nucleic acids extracted from the feather shafts was described are, Marek's disease virus, circoviruses, chicken anemia virus, fowlpox virus, avian retroviruses, avian influenza virus and infectious laryngotracheitis virus. In two cases, of Marek's disease virus and of infectious laryngotracheitis virus, the differentiation of vaccine and wild-type viruses from feather shafts was made possible, thus allowing for monitoring the vaccination efficacy. The present review demonstrates also the stability of DNA viruses in feather shafts, and the possible evaluation of environmental dissemination of pathogens. When viruses are transmitted vertically, like in the cases of the retrovirus REV, a teratogenic effect on the development of feathers of the day-old newly hatched chick might occur in the case of avian influenza and the chicken anemia virus, which might indicate on a viral infection.

  5. Wokół współczesnej sztuki dramatycznej w Polsce

    Directory of Open Access Journals (Sweden)

    Marek Hendrykowski

    2015-11-01

    Full Text Available Polish contemporary drama (which is represented by a range of authors, from Tadeusz Różewicz and Sławomir Mrożek, Janusz Głowacki, Wiesław Myśliwski, Eustachy Rylski, Marek Koterski and Tadeusz Słobodzianek to Przemysław Wojcieszek, Michał Walczak, Piotr Tomaszuk, Tomasz Man and Dorota Masłowska seems to be an integral part and a special, local manifestation of profound changes that have taken place in the European and American drama of the 20th and 21st centuries. Samuel Beckett, Eugène Ionesco, Tennessee Williams, Harold Pinter, John Osborne and Edward Albee influenced Polish dramaturgy, i.e. its general concept and philosophy, in many ways. They were pioneers and patrons of this transformation, just as Miron Białoszewski was in Poland. New Polish dramaturgy continues to go in this direction while looking for modern means of theatrical expression. Marek Hendrykowski examines and describes twenty-one contemporary dramas that are collected in two volumes titled Trans/formacja. Dramat polski po 1989 roku [Trans/formation: An Anthology of Polish Contemporary Drama after 1989], which were edited by Jacek Kopciński. The author of this article searches for features and “common places” (loci communes that are typical of this form of art.

  6. Przezroczysta lekkość bytu – od Calvina do Bieńczyka

    Directory of Open Access Journals (Sweden)

    Monika Błaszczak

    2016-06-01

    Full Text Available Transparency is one of physical esthetic categories that are used to describe literature and other arts. The main aim of this paper is to show how those esthetic categories are used on three levels: esthetic, performatively dramatic and philosophical in modern literature, theater, film and fine arts. The starting point for those considerations are methods of Italo Calvino (“American lectures” and Marek Bieńczyk (his collection of essays titled “Transparency” . Calvino’s category of “transparency” (in his attempt to go beyond anthropocentric cognition with the author’s main question: “Is imagination an instrument of cognition?” is contrasted with Marek Bieńczyk’s term of “transparency”, who has pointed out the positive aspects of paintings (which are not only giving a feeling of emptiness but also provide certainty of clarity and obviousness. In addition to these categories, lucidity and glassiness are featured and a crystal structure is summoned in the context of mistiness as its opposition.

  7. LHC gets the ball rolling

    CERN Document Server

    2007-01-01

    1. The multidisciplinary team responsible for the RF ball project to check the interconnections. From left to right: Rhodri Jones (AB/BI), Eva Calvo (AB/BI), Francesco Bertinelli (AT/MCS), Sonia Bartolome Jimenez (TS/IC), Sylvain Weisz (TS/IC), Paul Cruikshank (AT/VAC), Willemjan Maan (AT/VAC), Alain Poncet (AT/MCS), Marek Gasior (AB/BI).2. During the tests the ball is inserted very carefully into the vacuum chamber.1. Le groupe pluridisciplinaire qui a mené le projet de balle RF pour vérifier les interconnexions avec, de gauche à droite, Rhodri Jones (AB/BI), Eva Calvo (AB/BI), Francesco Bertinelli (AT/MCS), Sonia Bartolome Jimenez (TS/IC), Sylvain Weisz (TS/IC), Paul Cruikshank (AT/VAC), Willemjan Maan (AT/VAC), Alain Poncet (AT/MCS) et Marek Gasior (AB/BI).2. Lors des tests, la balle est insérée dans la chambre à vide avec beaucoup de précaution.

  8. [Role of vaccination in animal health].

    Science.gov (United States)

    Pastoret, Paul-Pierre

    2012-03-01

    According to the IFAH, veterinary vaccines currently account for 26% of the global market in veterinary medicines, reflecting the importance of vaccines in animal health, as well as the number of wild and domesticated target species, and the monospecific nature of most vaccines. Multispecies vaccines include tetanus and rabies. In 2010, the number of food-producing animals was estimated to be roughly 20 billion and is rising gradually. Fowl currently represent the main food species. Veterinary vaccination has allowed the eradication of rinderpest, as officially declared last year (2011), jointly by the World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation of the United Nations (FAO). Rinderpest was a real scourge, and was only the second viral disease to be totally eradicated (after human smallpox). One characteristic of veterinary vaccination is the DIVA approach, "differentiating infected from vaccinated animals". The DIVA strategy is especially interesting for regulated control of diseases like foot-and-mouth disease, infectious bovine rhinotracheitis, pseudorabies, and classical swine fever. DIVA vaccination requires prior serological testing. Vaccination is also used for wild animals such as foxes (rabies) and wild boars (classical swine fever). "In ovo" vaccination of fowl on day 18 of the incubation period is used to prevent Marek's disease for instance, and double vaccination (vector and insert) to prevent both Marek's disease and Gumboro's disease in fowl. Animal vaccination can also help to protect human health, as illustrated by fowl vaccination against salmonellosis.

  9. Esileedi Evelin Ilves läheb Kaleviga kommisõtta / Priit Pullerits ; kommenteerinud Monika Heinrand

    Index Scriptorium Estoniae

    Pullerits, Priit, 1965-

    2009-01-01

    Liikuvat eluviisi ja tervislikku toitumist propageeriv proua Evelin Ilves on otsustanud alustada võitlust transrasvhappeid sisaldavate toiduainete vastu. Proua E. Ilves koostas nimekirja maiustustetootja Kalevi kommidest, mis märgistuse järgi sisaldavad transrasvu. Arvamust avaldavad Kalevi turundus- ja müügidirektor Monika Heinrand, kirjanik Andrus Kivirähk, koduperenaine Kadi Tarand, Tallinna Tehnikaülikooli toiduainete instituudi direktor professor Raivo Vokk. Vastukajad artiklile vt. Postimees 30. sept. 2009, lk. 15: Petrone, Epp. Poes tuleb tähelepanelik olla; Tuiksoo, Ester. Hoidkem Eesti toitu ja toiduainetetööstust; Õhtuleht 3. okt. 2009, lk. 7: Kerge, Rainer. Mahetomat tapab!; Eesti Päevaleht 5. okt. 2009, lk. 2: Teemägi, Tiina. Aasta turundustegu; Pehme, Sirli. Transrasvu tuleb vältida; Õhtuleht 5. okt. 2009, lk. 8: Kummardus Evelinile!; Rulluisud ja transrasvad; Terviseleht 6. okt. 2009, lk. 2: Laane, Aleksander. Solaariumid ja transrasvad; Postimees 13. okt. 2009, lk. 12-13: Strider, Roy. Kellele on transrasvad kasulikud?; Kambek, Liis. Transrasvhapped on üleilmne probleem; Postimees 17. okt. 2009, lk. 14: Kuusk, Hendrik. Toidupoes ei müüda mürgikokteile; Õhtuleht 24. okt. 2009, lk. 9: Levin, Adik. Igaühel on õigus toituda tervislikult; Eesti Päevaleht 27. okt. 2009, lk. 3: Trisberg, Aet. Luubiga poodi; Postimees : AK 5. dets. 2009, lk. 12 karikatuur transrasvade teemal

  10. The Prevalence of Only-Child Status Among Children and Adolescents Referred to a Gender Identity Service Versus a Clinical Comparison Group.

    Science.gov (United States)

    Hughes, S Kathleen; VanderLaan, Doug P; Blanchard, Ray; Wood, Hayley; Wasserman, Lori; Zucker, Kenneth J

    2017-08-18

    Several studies indicate that homosexual males have a high proportion of older brothers compared to heterosexual males. Natal males with gender dysphoria who are likely to be homosexual also display this sibship pattern. Until recently, there was little evidence linking homosexuality and/or gender dysphoria in females to unique sibship characteristics. Two studies have indicated that natal female youth clinically referred for gender dysphoria are more likely to be only children (Schagen, Delemarre-van de Waal, Blanchard, & Cohen-Kettenis, 2012; VanderLaan, Blanchard, Wood, & Zucker, 2014). However, these studies did not include control groups of youth clinically referred for other reasons. Thus, it is unclear whether the increased likelihood of only-child status is specific to gender-referred natal females. This study compared only-child status among youth referred to a mental health service for gender dysphoria (778 males, 245 females) versus other reasons (783 males, 281 females). Prehomosexual gender-referred males were less likely to be only children than clinical controls. Contrary to previous findings, gender-referred females were not more likely to be only children, indicating that increased likelihood of only-child status is not specific to gender-referred females, but is characteristic of clinic-referred females more generally.

  11. Navigating a Precarious Balance: The Noel Garovillo Dance Center's Contemporary Dance as a Commitment to the Community

    Directory of Open Access Journals (Sweden)

    Ruth Jordana Luna Pison

    2011-12-01

    Full Text Available If it is difficult to picture a ballet school located in Koronadal, South Cotabato, then perhaps it will even take more than a stretch of the imagination to conceive of how contemporary dance survives in Southern Philippines. The story behind the KAHAYAG Community Dance and Theater Company, later reorganized and renamed as the Noel Garrovillo Dance Center, is a narrative of how, notwithstanding the obstacles faced by dance in the regions, sheer conviction and commitment could keep the art form alive. It is also a story of how a dance director and his company had to resolve their contradictions as Christian artist settlers in Mindanao. This paper discusses how contemporary dance as a flexible and dynamic dance form has allowed them to create pieces that they could consider their “own.” From their initial works that borrowed movements from the T’bolis and B’laans, to their current choreographies based on their realities as settlers in Koronadal, Garrovillo’s company has continuously worked to make dance part of the local government’s agenda on cultural and the arts. As cultural brokers, they are faced with both choreographic and intellectual imperatives. Garrovillo believes that there is a need to strengthen the country’s creative industry so that choreographers will have opportunities to create works which are crucial to the life of the nation.

  12. „Rejs" jako gatunek

    Directory of Open Access Journals (Sweden)

    Marek Hendrykowski

    2007-06-01

    Full Text Available Marek Piwowski's film „Rejs" (The Cruise made in 1969 and the premiere of which was on 10 October 1970 at „Bajka" cinema in Warsaw, rightly (deserves to be one of the most popular Polish films of all time. This study attempts to offer a more complete characterisation of the feature of the genre of this unusual work of film art. It is commonly thought that „Rejs" is a comedy. Against the background of the model of comedy of the 60s of the 20th century, however, it is a comedy of a very special kind. The author does not doubt the comedic character of Piwowski's film, but points to different possible from those used until now ways of interpreting this film (a holiday comedy, anti-production film, social satire, pamphlet, psychodrama, sociodrama, starting from the assumption that the genre instruction written into this work contains a much richer repertoire of possible interpretations.

  13. A film adaptation – a translation or montage?

    Directory of Open Access Journals (Sweden)

    Seweryna Wysłouch

    2014-01-01

    Full Text Available This article presents arguments against some of the ideas presented in Marek Hendrykowski’s paper Adaptacja jako przekład intersemiotyczny [Adaptation as intersemiotic translation] („Przestrzenie Teorii” [Space of Theory] no. 20 (2013. The author challenges two assumptions: 1 the list of translation operations which was proposed by Hendrykowski and which she considers to be heterogeneous: these operations are performed either on a text’s surface (rhetorical operations or in its deep structure (transaccentuation, compression and amplification; and 2 the concept of adaptation which is understood as montage, since the idea of montage restricts the issue of translation to compositional activities and isolates it from sources of hermeneutic and cognitive inspiration.

  14. Crusading and Chronicle Writing on the Medieval Baltic Frontier

    DEFF Research Database (Denmark)

    of crusading and the relationship between the peripheries and core areas of Europe. While recent years have produced a significant amount of new research into Henry of Livonia, much of it has been limited to particular historical traditions and languages. A key objective of this book, therefore...... images brought into existence by the amalgamation of crusading and missionary ideology and the frontier experience. This is followed by studies on 'Practices,' which examines the chronicle's reflections of the diplomatic, religious, and military practices of the christianisation and colonisation......, Jüri Kivimäe; Henry the interpreter: language, orality and communication in the 13th-century Livonian mission, Alan V. Murray; Martyrs and miracles: depicting death in the Chronicle of Henry of Livonia, Marek Tamm; Henry of Livonia on woods and wilderness, Torben Kjersgaard Nielsen; 'Verbis non...

  15. Measurement of Beam Tunes in the Tevatron Using the BBQ System

    Energy Technology Data Exchange (ETDEWEB)

    Edstrom, Dean R.; /Indiana U.

    2009-04-01

    Measuring the betatron tunes in any synchrotron is of critical importance to ensuring the stability of beam in the synchrotron. The Base Band Tune, or BBQ, measurement system was developed by Marek Gasior of CERN and has been installed at Brookhaven and Fermilab as a part of the LHC Accelerator Research Program, or LARP. The BBQ was installed in the Tevatron to evaluate its effectiveness at reading proton and antiproton tunes at its flattop energy of 980 GeV. The primary objectives of this thesis are to examine the methods used to measure the tune using the BBQ tune measurement system, to incorporate the system into the Fermilab accelerator controls system, ACNET, and to compare the BBQ to existing tune measurement systems in the Tevatron.

  16. A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system.

    Science.gov (United States)

    Tang, Na; Zhang, Yaoyao; Pedrera, Miriam; Chang, Pengxiang; Baigent, Susan; Moffat, Katy; Shen, Zhiqiang; Nair, Venugopal; Yao, Yongxiu

    2018-01-29

    Herpesvirus of turkeys (HVT) has been successfully used as live vaccine against Marek's disease (MD) worldwide for more than 40 years either alone or in combination with other serotypes. HVT is also widely used as a vector platform for generation of recombinant vaccines against a number of avian diseases such as infectious bursal disease (IBD), Newcastle disease (ND) and avian influenza (AI) using conventional recombination methods or recombineering tools on cloned viral genomes. In the present study, we describe the application of CRISPR/Cas9-based genome editing as a rapid and efficient method of generating HVT recombinants expressing VP2 protein of IBDV. This approach offers an efficient method to introduce other viral antigens into the HVT genome for rapid development of recombinant vaccines. Copyright © 2018 The Pirbright Institute. Published by Elsevier Ltd.. All rights reserved.

  17. Mesoporous Silica-Supported Metal Oxide-Promoted Rh Nanocatalyst for Selective Production of Ethanol from Syngas

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, George

    2010-09-30

    The objective is to develop a process that will convert synthesis gas from coal into ethanol and then transform the ethanol into hydrogen. Principal investigators from Iowa State University include Dr. George Kraus, Dr. Victor Lin, Marek Pruski, and Dr. Robert Brown. Task 1 involves catalyst development and catalyst scale up. Mesoporous manganese silicate mixed oxide materials will be synthesized, characterized and evaluated. The first-and secondgeneration catalysts have been prepared and scaled up for use in Task 2. The construction of a high-pressure reactor system for producing synthetic liquid fuel from simulated synthesis gas stream has been completed as the first step in Task 2. Using the first- and second generation catalysts, the reactor has demonstrated the production of synthetic liquid fuel from a simulated synthesis gas stream.

  18. ISOLDE’s rarest isotopes

    CERN Multimedia

    Katarina Anthony

    2013-01-01

    The ISOLDE physics section (PH-SME-IS) has recently observed an unusual transformation… one that may well be a sign of things to come for CERN.   The ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner* (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz* (applied fellow), Monika Stachura (future applied fellow). Not in the photo: Kara Lynch (PhD student). Although more and more women are going into the physical sciences, it’s no secret that it remains a male-dominated field. But over the past six months, the ISOLDE PH section has become an exception to this rule: with female physicists outnumbering their male colleagues 3 to 1. “We’re probably one of the few teams at CERN where the personnel is mostly female,” says Magdalena Kowalska, the ISOLDE Physics Coordinator. &am...

  19. Clinical application and research of tumor markers in colorectal cancer

    International Nuclear Information System (INIS)

    Chen Yumei

    2005-01-01

    Colorectal cancer is one of the most common malignant tumors. There are many tumor markers for detecting colorectal cancer, some of which have been widely used in clinical area. However, still lack an ideal tumor marker of colorectal cancer. In this review, we simply characterized some common tumor markers including carcinoembryonic antigen, CA19-9, CA50, CA242 etc and their dignostic value. And here we discussed some combined detecting procedures which improve diagnostic accuracy of colorectal cancer. In addition, with the development of the biomoleculer technique, some newly discovered tumor markers and genetic marekers have gained great progress in the research of colorectal cancer, and will become a promissing technique in the diagnosis of colorectal cancer. (authors)

  20. Dicty_cDB: Contig-U04064-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ( FD686515 ) CBHX5739.rev CBHX Mycosphaerella fijiensis MfEST4... 38 0.068 2 ( FG292734 ) 1108770641730 New World... Screwworm Larvae 9387 EST... 38 0.069 3 ( FG293376 ) 1108770670007 New World Screwworm Larvae 9387 EST...... 38 0.069 3 ( FG292982 ) 1108770653482 New World Screwworm Larvae 9387 EST... 38 0.073 3 ( FG300950 ) 1108799246492 New World...05 Marek's disease virus-infected spleen... 40 2.4 2 ( FG294814 ) 1108770718996 New World...C... 32 2.6 2 ( EH523252 ) FDR107-P00037-DEPE-R_J20 FDR107 Danio rerio cDNA ... 36 2.7 2 ( FG300042 ) 1108793358690 New World

  1. Franchising as a Way of Creating Entrepreneurship and Innovation

    Directory of Open Access Journals (Sweden)

    Lewandowska Lucyna

    2014-09-01

    Full Text Available Artykuł traktuje o franczyzie jako koncepcji prowadzenia działalności gospodarczej na podstawie uzgodnionego przez strony układu ekonomicznego. Dostarcza informacji o genezie franczyzy, uwarunkowaniach jej rozwoju w świecie i Polsce. Prezentuje udokumentowane tendencje wzrostu polskiego rynku franczyzowego z uwzględnieniem rodzimych i zagranicznych marek franczyzowych. Zwraca uwagę na atuty franczyzy pozwalające jej oprzeć się kryzysom gospodarczym, stymulować rozwój przedsiębiorczości i innowacyjności oraz minimalizować ryzyko biznesowe. Zawiera również komentarze, spostrzeżenia, sugestie i konstatacje na temat efektów synergicznych uzyskiwanych w firmach i całej polskiej gospodarce z tytułu zastosowań franczyzy.

  2. Professor Michal Kleiber, Minister of Science, Chairman of the State Committee for Scientific Research Republic of Poland

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Visit of the Polish Minister of Sciences and Information Technology, Professor Michal Kleiber (centre), in front of the large support structures ("trucks") constructed in Poland for the ATLAS experiment, accompanied by members of Polish delegation, ATLAS representatives, and Cracow physicists and engineers (from left to right): Dr Jacek Blocki, Prof. Jerzy Niewodniczanski (President, National Atomic Energy Agency), Dr Szymon Gadomski, Dr Tommi Nyman (ATLAS experiment), Prof. Michal Turala, Edward Gornicki, Dr Peter Jenni (ATLAS spokesman), Mr Piotr Golonka, H.E. Mr Stanislaw Przygodski (Ambassador, Deputy Permanent Representative of the Republic of Poland to the United Nations in Geneva), Prof. Jan Godlewski, Ryszard Sosnowski (Vice-President of CERN Council), Dr Marek Stodulski and Mr Jerzy HalikPolish Minister of Sciences and Information Technology, on 17th October 2003.

  3. Areeni aasta album. Isiklikud edetabelid

    Index Scriptorium Estoniae

    2003-01-01

    Areen jagas punkte heliplaatidele: 1. The Streets "Original Pirate Material" 2. Common "Electric Circus" 3. Flaming Lips "Yoshimi Battles The Pink Robots" 4. DJ Shadow "Private Press" 5. Peven Everett "Studio Confessions" 6. Andrew WK "I Get Wet" 7. Underworld "A Hundred Days Off" 8.-9. Felix Da Housecat "Kittenz and Thee Glitz" 10. X-Press 2 "Muzikizum" 11. The Music "The Music" 12.-13. The Datsuns "The Datsuns" 12. 13 Peshay "Fuzion" 14. High Contrast "True Colours" 15. Tallinn 73 meets Kalm "Autopiloot" 16. Koop "Waltz For Koop" 17.-18. Death In Vegas "Scorpio Rising" 17.-18. A "Hi-Fi-Serious" 19.-20. Arto Lindsay "Invoke" 19.-20. Akufen "My Way". Isiklikud edetabelid Tõnu Kaalepilt, Marek Kallinilt, Erkki Luukilt, Tõnis Kahult, Raul Saaremetsalt, Siim Nestorilt, Koit Raudsepalt, Erik Mornalt, Mart Juurelt ja Märt Milterilt

  4. [Obtaining the Impact Factor by Ginekologia Polska].

    Science.gov (United States)

    Spaczyński, Marek; Januszek-Michalecka, Lucyna; Nowak-Markwitz, Ewa; Kedzia, Witold; Spaczyński, Robert; Karowicz-Bilińska, Agata

    2011-08-01

    Scientific journals are ranked and evaluated to measure their relative importance and influence on science within a specific field. One of the tools most widely used to evaluate and compare journals is the Thomson Reuters Impact Factor In Poland a specific value of a scientist's Impact Factor is required for academic promotion. Ginekologia Polska was placed on the Master Journal List in 2008 in the result of changes introduced in 2007 by the new Chief Editor prof. Marek Spaczynski. In 2010, first time in its history the journal was listed in the Journal Citation Reports with the Impact Factor 0.367. The analysis of Ginekologia Polska contemporary value, as well as of prospects for its development was conducted on the basis of the Journal Citation Reports. In the light of the JCR data, Ginekologia Polska is a highly regarded title compared to other Polish journals. Its value and importance is gradually growing.

  5. Gombrowicz a polski film fabularny

    Directory of Open Access Journals (Sweden)

    Jacek Nowakowski

    2013-01-01

    Full Text Available This article presents the influence that Witold Gombrowicz’s work has had on Polish cinema. It covers several generations of directors, for example, Andrzej Munk (born in the 1920s, Roman Polański and Jerzy Skolimowski (born in the 1930 as well as Agnieszka Holland, Piotr Szulkin and Marek Koterski (born in the 1940s and 1950s, and discusses the topic of film adaptations of his books (Jerzy Skolimowski’s Ferdydurke and Jan Jakub Kolski’s Pornografia [Pornography]. The article shows that Polish cinema uses Gombrowicz’s works most of all by taking up the issue of life’s authenticity and inauthenticity as well as to demythologize Polish tradition and history. As for esthetics, it employs Gombrowicz’s favorite style, i.e. the grotesque.

  6. Immunity to cancer

    Science.gov (United States)

    1973-01-01

    Preventive vaccination is successfully practised today against two neoplastic diseases of domestic animals: fibropapillomatosis of cattle and Marek's disease of chickens (a lymphoproliferative disease). Also it may soon be possible to immunize cats against lymphosarcoma. This memorandum describes these diseases and the immunological reactions involved. It also mentions a number of other tumours that could be used for immunological studies. The greatest advances in immunity have been made with the tumours caused by viruses. The killed papillomavirus vaccine used against bovine papillomatosis produces demonstrable antibodies against the virus. In the case of Marek's disease of chickens, which is due to a herpesvirus, a live virus vaccine is used. This does not prevent infection with virulent virus, but prevents the development of neoplasia. The mechanism by which the vaccine produces its effect is not yet known. Immunization with live and with killed vaccines has been successfully carried out experimentally against leukosis of chickens, which is caused by an oncornavirus. There is evidence that it will be possible to vaccinate cats against lymphosarcoma with non-living vaccine. Naturally occurring cancer in domestic animals parallels cancer in man more closely than does experimentally induced cancer in inbred laboratory animals; therefore immunological studies with the former are more likely to yield results relevant to the problem in man. Experimental cancer in rodents provides models that have the great advantages of uniformity and availability, and they cannot be replaced. However, models in domestic animals offer valuable supplementary systems for research aimed at elucidating the basic principles of immunity to cancer. PMID:4363397

  7. Evaluation of a Probiotic and a Competitive Exclusion Product Inoculated In Ovo on Broiler Chickens Challenged with Salmonella Heidelberg

    Directory of Open Access Journals (Sweden)

    IGO Silva

    Full Text Available ABSTRACT The present study evaluated a probiotic and a competitive exclusion product injected in ovo on day 18 of incubation together with Marek's disease vaccine in eggs of 56-week-old broiler breeders. Three experiments were carried out. The first trial evaluated the effect of treatments on hatchability, cecal colonization of Salmonella Heidelberg (SH, and intestinal mucosa immunity (immunoglobulin A levels in the intestinal fluid. The second trial evaluated the viability of the microorganisms in the products inoculated in a solution containing diluent and Marek's disease vaccine. The third trial evaluated the colonization of the cecal microbiota in non-challenged chickens during first four days of life by culturing cecal samples under aerobic and anaerobic conditions. Hatchability was not affected by the treatments. SH cecal counts were reduced in three-day-old broilers inoculated in ovo with the competitive exclusion product. Liver and spleen pool SH counts were not different among treatments. Broilers inoculated in ovo presented higher intestinal IgA titers 24 hours after SH challenge compared with the controls. When birds were not challenged, lower cecal microbial counts in aerobic culture were determined in the control group than in the probiotic group on day 3, and in the competitive exclusion group on day 2 when cultured in anaerobiosis. The products inoculated and diluted in the vaccine solution were viable at all analyzed periods when cultured in anaerobiosis. The results of this study suggest in-ovo inoculation is an effective route for the administration of the evaluated products, which effectively enhanced the broilers' immune response to a SH challenge, as shown by the increase in IgA titers, and the reduction in cecal Salmonella Heidelberg colonization with the in-ovo inoculation with the competitive exclusion product.

  8. Genetic analisys of a cross of gaillon (Brassica oleracea var. alboglabra with cauliflower (B.oleracea var. botrytis

    Directory of Open Access Journals (Sweden)

    Vanessa B.M.G. Spini

    2000-03-01

    Full Text Available The cauliflower (Brassica oleracea var. botrytis is an annual vegetable cultivated in Southern and Southwestern Brazil with limited production in the Northeast and Centralwest. A variety of Chinese kale, "kaai laan" or "gaillon" (Brassica oleracea var. alboglabra, produces seeds at high temperatures and therefore can do so in North and Northeastern Brazil. Gaillon and cauliflower were crossed 55 times using 10 gaillon plants as mothers and 4 cauliflower plants as pollen donors. From these crosses, in the F2 generation, 612 plants with inflorescence like gaillon and 48 plants with inflorescence like cauliflower were obtained, in a proportion similar to 15:1, implying that 2 pairs of genes entered into formation of the cauliflower inflorescence type. In order to study flower color, 339 plants were analyzed: 274 presented white flowers and 65, yellow flowers, denoting that this caracter is determined by 1 pair of genes, white being dominant over yellow; white flowers had a slighly higher adaptive value in our population. The characteristic waxy leaf showed a proportion of 3 waxy plants for 1 not waxy, indicating the action of one pair of genes.A couve-flor (Brassica oleracea var. botrytis é um vegetal anual e tem seu cultivo no Brasil limitado às regiões Sul e Sudeste, com pequena produção no Nordeste e Centro-Oeste. Uma variedade de couve da China, "kaai laan" ou "gaillon" (Brassica oleracea var. alboglabra, produz sementes em altas temperaturas e, portanto, é apta a produzir sementes no Norte e Nordeste do Brasil. Gaillon e couve-flor foram cruzados. Foram feitos 55 cruzamentos usando 10 plantas de gaillon como mãe e 4 plantas de couve-flor como doadores de pólen. Desses cruzamentos, na geração F2, 612 plantas com inflorescência tipo gaillon e 48 plantas com inflorescência tipo couve-flor foram obtidas, em proporção similar a 15:1, demonstrando que 2 pares de genes estão envolvidos na formação da inflorescência em couve

  9. A comparative assessment of endogenous water institutional change

    Science.gov (United States)

    Pande, Saket; Ersten, Maurits

    2013-04-01

    This paper builds the theory of endogenous institutional change, first proposed by Greif and Laitin (2004), for water scarce regions in context of water institutions. The current emphasis on environmental change, including hydrological change, largely ignores the adaptation of human societies to change. Humans have mostly been considered as boundary conditions or parameters of the dynamics of hydrological change and are not considered as conduits of feedbacks. Nonetheless, the dynamical representation of hydrological change with feedbacks between various components of a system is assuring since it is reminiscent of processual ecological anthropology(Orlove, 1980), except that individual decision making is absent. This paper proposes to consider selected dryland basins of the world, to conceptualize proxies of water relevant socio-economic organisation, such as spatial scales of upstream-downstream cooperation in water use, synthesized over time and then proposes a comparative assessment to test regularities predicted by an extension of river game theory (Ambec and Ehlers, 2008; van der Brink et al, 2012) to endogenous institutional change. References: Orlove, B. S. (1980). Ecological Anthropology. Annual Review of Anthropology, Vol. 9 (1980), pp. 235-273. Greif. A. and D. D. Laitin (2004). A Theory of Endogenous Institutional Change. American Political Science Review, Vol. 98, No. 4 November 2004. Ambec, S. and L. Ehlers (2008). Sharing a river amongst satiable agents. Games and Economic Behavior, 64, 35-50. Van der Brink, G. van der Laan and N. Moes (2012). Fair agreements for sharing international rivers with multiple springs and externalities. Journal of Environmental Economics and Management, 63, 388-403.

  10. Variable selection for confounder control, flexible modeling and Collaborative Targeted Minimum Loss-based Estimation in causal inference

    Science.gov (United States)

    Schnitzer, Mireille E.; Lok, Judith J.; Gruber, Susan

    2015-01-01

    This paper investigates the appropriateness of the integration of flexible propensity score modeling (nonparametric or machine learning approaches) in semiparametric models for the estimation of a causal quantity, such as the mean outcome under treatment. We begin with an overview of some of the issues involved in knowledge-based and statistical variable selection in causal inference and the potential pitfalls of automated selection based on the fit of the propensity score. Using a simple example, we directly show the consequences of adjusting for pure causes of the exposure when using inverse probability of treatment weighting (IPTW). Such variables are likely to be selected when using a naive approach to model selection for the propensity score. We describe how the method of Collaborative Targeted minimum loss-based estimation (C-TMLE; van der Laan and Gruber, 2010) capitalizes on the collaborative double robustness property of semiparametric efficient estimators to select covariates for the propensity score based on the error in the conditional outcome model. Finally, we compare several approaches to automated variable selection in low-and high-dimensional settings through a simulation study. From this simulation study, we conclude that using IPTW with flexible prediction for the propensity score can result in inferior estimation, while Targeted minimum loss-based estimation and C-TMLE may benefit from flexible prediction and remain robust to the presence of variables that are highly correlated with treatment. However, in our study, standard influence function-based methods for the variance underestimated the standard errors, resulting in poor coverage under certain data-generating scenarios. PMID:26226129

  11. Between Looking and Making: Unravelling Dom Hans van der Laan’s Plastic Number

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    Caroline Voet

    2016-01-01

    Full Text Available Between 1920 and 1991, the Dutch Benedictine monk and architect Dom Hans van der Laan (1904–91 developed his own proportional system based on the ratio 3:4, or the irrational number 1.3247. . ., which he called the plastic number. According to him, this ratio directly grew from discernment, the human ability to differentiate sizes, and as such would be an improvement over the golden ratio. To put his theories to the test, he developed an architectural language, which can best be described as elementary architecture. His oeuvre — four convents and a house — is published on an international scale. His buildings have become pilgrimage sites for practicing architects and institutions that want to study and experience his spaces. His 1977 book 'Architectonic Space: Fifteen Lessons on the Disposition of the Human Habitat', translated into English, French, German and Italian, still inspires architects today, as does his biography, 'Modern Primitive', written by the architect Richard Padovan in 1994. But beyond the inspiration of his writings and realisations, the actual application of the plastic number in Van der Laan’s designs is unclear. Moreover, Van der Laan’s theories seem to be directed towards one goal only: to present the plastic number as the only possible means by which eminent architecture can be achieved, making them a target for suspicion and critique. To understand and evaluate Van der Laan’s application of the plastic number, this paper approaches it as a practical design tool. It analyses its genealogy and defines its key concepts. From that framework, Van der Laan’s architectonic space is interpreted as a design methodology that combines antique tectonic theories reminiscent of writers from Plato to Vitruvius with more recent atectonic approaches towards space through experience and movement.

  12. Recombinant Gallid herpesvirus 2 with interrupted meq genes confers safe and efficacious protection against virulent field strains.

    Science.gov (United States)

    Zhang, Yanping; Liu, Changjun; Yan, Fuhai; Liu, Ailing; Cheng, Yun; Li, Zhijie; Sun, Guorong; Lv, Hongchao; Wang, Xiaomei

    2017-08-24

    Gallid herpesvirus 2 (GaHV-2) continuously evolves, which reduces the effectiveness of existing vaccines. To construct new GaHV-2 candidate vaccines, LMS, which is a virulent GaHV-2 field strain isolated from diseased chicken flocks in Southwest China in 2007, was modified such that both copies of its meq oncogene were partially deleted. The resulting virus, i.e., rMSΔmeq, was characterized using PCR and sequencing. To evaluate the safety and protective efficacy of rMSΔmeq, specific pathogen-free (SPF) chickens were inoculated with 2000 plaque forming units (pfu) and 20,000pfu of rMSΔmeq immediately after hatching. All birds grew well during the experimental period, and none of the challenged chickens developed Marek's disease-associated lymphoma. In addition, the rMSΔmeq- and CVI988/Rispens-vaccinated SPF chickens were challenged with 1000 pfu and 5000 pfu of the representative virulent GaHV-2 Md5 strain and 1000 pfu of the variant GaHV-2 strains LCC or LTS. The results showed that the rMSΔmeq strain provided complete protection, which was similar to that provided by the CVI988/Rispens vaccine (protective index (PI) of 95.5) when challenged with a conventional dose of the Md5 strain. However, rMSΔmeq provided a PI of 90.9 when challenged with 5000 pfu of the Md5 strain, which was significantly higher than that provided by the CVI988/Rispens vaccine (54.5). rMSΔmeq provided a PI of 86.4 against LCC, which was equal to that provided by the CVI988/Rispens vaccine (81.8). In addition, rMSΔmeq provided a PI of 100 against LTS, which was significantly higher than that provided by the CVI988/Rispens vaccine (68.2). Altogether, the rMSΔmeq virus provided efficient protection against representative and variant GaHV-2 strains. In conclusion, the rMSΔmeq virus is a safe and effective vaccine candidate for the prevention of Marek's disease and is effective against the Chinese variant GaHV-2 strains. Copyright © 2017. Published by Elsevier Ltd.

  13. Foreword

    Energy Technology Data Exchange (ETDEWEB)

    Sujkowski, Z. [The Andrzej Soltan Institute for Nuclear Studies, Otwock-Swierk (Poland)

    1998-12-31

    The year 1997 was marked by the hundredth birthday anniversary of professor Andrzej Soltan, the first director of our Institute and the pioneer of nuclear physics in Poland. It is also about hundred years since nuclear physics has begun with the discovery of Polonium and Radium by Maria Sklodowska-Curie and Pierre Curie. In honour of these anniversaries an Exhibition entitled ``Nuclear Physics and Nuclear Technique in Service of Medicine - from Radium Needle to Accelerators`` has been organized. Some lectures, radio broadcasts, popular level articles have supplemented this effort to bring the present day nuclear sciences closer to the general public. In the year of 1997 227 articles in international journals have been published, supplemented by 24 invited talks and 219 communications at conferences. The lists of these publications are given separately for each of the Research Departments throughout this Annual Report. They are preceded by articles on the work in progress and by the brief overviews written by the Department Heads. The selected highlights of the past year are: progress in materials science (deep surface layers - on transformation of uranium lattice induced by water corrosion). The work on modification of surface properties by hot and cold ion implantation. In nuclear physics the careful study of polarization phenomena in the decay of light, weekly bound nuclei. The works on the properties of the heaviest elements have been continued (Adam Sobiczewski - international prizes: in 1997 the Alfred Jurzykowski and the Flerov prize). The study of new scintillation techniques provided by Marek Moszynski has also mentioned. The highlight this time is the demonstration of advantages offered by avalanche diodes for the light output readout. The particle physicists continue their involvement in various international projects. This year they managed to give a noteworthy instrumental and technical input to: Resistive Plate Chambers for the Compact Muon Solenoid

  14. CBIOS Science Sessions - 2015 - Part I

    Directory of Open Access Journals (Sweden)

    João Costa et al.

    2015-05-01

    Full Text Available Redox modulation by SOD mimics in renal cancer: from etiology to progression; Modulação redox por miméticos da SOD no cancro renal: da etiologia à progressão; João Costa. Role of the Notch pathway in female reproductive function; Papel da via Notch na função reprodutiva feminina; Daniel Murta; Marta Batista; Alexandre Trindade; Elisabete Silva; Luisa Mateus; António Duarte; Luís Costa. Skin permeation and in vivo antioxidant activity of gelatin nanoparticles; Permeação cutânea e actividade antioxidante in vivo de nanopartículas de gelatina; Camila Areias de Oliveira Isolation, modeling and phytosome forms of antiproliferative compounds from Plectranthus spp; Isolamento, modelação e formulações fitossomais de compostos antiproliferativos obtidos de plantas do género Plectranthus; Diogo Matias, Marisa Nicolai, A. S. Fernandes, Nuno Saraiva, M. Fátima Simões, Ana Diaz Lanza, Catarina Pinto Reis, Patricia Rijo. Role of SOD mimetics in breast cancer metastization; Papel de miméticos da SOD em metastização do cancro da mama; Ana Catarina Flórido. Royleanone derivatives from Plectranthus grandidentatus and its topical application through drug delivery nanosystems; Derivados de roileanona de Plectranthus grandidentatus e a sua aplicação tópica em nanossistemas para veiculação de fármacos; Filipe Pereira, M. J. Cebola, Rita Sobral, Ana Diaz Lanza, Lia Ascenção, Carlos Afonso, Catarina Pinto Reis, Patrícia Rijo. Research in dental veterinary medicine; Investigação em medicina dentária veterinária; João Filipe Requicha. Marek's disease virus (MDV ibiquitin-specific protease (USP performs critical functions beyond its enzymatic activity during virus replication; O papel das proteases específicas da ubiquitina na replicação viral e oncoginese induzida pelo virus da doença de Marek; Inês M.V. Veiga, Keith W. Jarosinski, Benedikt B. Kaufer, Nikolaus Osterrieder.

  15. Dementia and delirium, the outcomes in elderly hip fracture patients

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    Mosk CA

    2017-03-01

    Full Text Available Christina A Mosk,1 Marnix Mus,1 Jos PAM Vroemen,1 Tjeerd van der Ploeg,2 Dagmar I Vos,1 Leon HGJ Elmans,3 Lijckle van der Laan1 1Department of Surgery, Amphia Hospital, Breda, 2Department of Public Health, Erasmus MC–University Medical Center, Rotterdam, 3Department of Orthopedic Surgery, Amphia Hospital, Breda, the Netherlands Background: Delirium in hip fractured patients is a frequent complication. Dementia is an important risk factor for delirium and is common in frail elderly. This study aimed to extend the previous knowledge on risk factors for delirium and the consequences. Special attention was given to patients with dementia and delirium.Methods: This is a retrospective cohort study performed in the Amphia Hospital, Breda, the Netherlands. A full electronic patient file system (Hyperspace Version IU4: Epic, Inc., Verona, WI, USA was used to assess data between January 2014 and September 2015. All patients presented were aged ≥70 years with a hip fracture, who underwent surgery with osteosynthesis or arthroplasty. Patients were excluded in case of a pathological or a periprosthetic hip fracture, multiple traumatic injuries, and high-energy trauma. Patient and surgical characteristics were documented. Postoperative outcomes were noted. Delirium was screened using Delirium Observation Screening Scale and dementia was assessed from medical notes.Results: Of a total of 566 included patients, 75% were females. The median age was 84 years (interquartile range: 9. Delirium was observed in 35%. Significant risk factors for delirium were a high American Society of Anesthesiology score, delirium in medical history, functional dependency, preoperative institutionalization, low hemoglobin level, and high amount of blood transfusion. Delirium was correlated with a longer hospital stay (P=0.001, increased association with complications (P<0.001, institutionalization (P<0.001, and 6-month mortality (P<0.001. Patients with dementia (N=168 had a

  16. Cognitive-Affective Dimensions of Female Orgasm: The Role of Automatic Thoughts and Affect During Sexual Activity.

    Science.gov (United States)

    Tavares, Inês M; Laan, Ellen T M; Nobre, Pedro J

    2017-06-01

    of automatic thoughts and of positive emotions experienced during sexual activity. Data were not collected face to face, which constitutes a strength of this study, because it is known that social desirability is lower in self-administered online questionnaires compared with traditional paper-and-pencil questionnaires, particularly for more sensitive sexual issues. The fact that the sample was composed of heterosexual, premenopausal, and relatively young women demands some caution regarding generalization of the present results. The findings support the contribution of cognitive and affective factors to female orgasmic functioning. It is recommended that future research confirm these findings with other samples, particularly clinical samples of women with orgasmic difficulties. Tavares IM, Laan ETM, Nobre PJ. Cognitive-Affective Dimensions of Female Orgasm: The Role of Automatic Thoughts and Affect During Sexual Activity. J Sex Med 2017;14:818-828. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  17. Effects of Aversive Classical Conditioning on Sexual Response in Women With Dyspareunia and Sexually Functional Controls.

    Science.gov (United States)

    Both, Stephanie; Brauer, Marieke; Weijenborg, Philomeen; Laan, Ellen

    2017-05-01

    association of sex with pain and possibly deficient safety learning play a role in dyspareunia. Both S, Brauer M, Weijenborg P, Laan E. Effects of Aversive Classical Conditioning on Sexual Response in Women With Dyspareunia and Sexually Functional Controls. J Sex Med 2017;14:687-701. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  18. Mercury in the Black Sea - results of the 2013 GEOTRACES MEDBlack cruise

    Science.gov (United States)

    Heimbürger, L. E.; Sonke, J.; Rijkenberg, M. J. A.; Gerringa, L. J.; De Baar, H. J. W.

    2014-12-01

    Inorganic mercury (Hg), whether of natural or anthropogenic origin, can be converted into the neurotoxin methylmercury (MeHg). Today we believe this conversion occurs during the bacterial remineralization of sinking organic matter in the oceanic water column. The Black Sea with its high organic matter inputs and anoxic deep waters is an excellent study site to investigate in more detail the processes yielding MeHg. To date only one vertical profile of Hg species near the Western shelf and one vertical profile in the Western Gyre are published (Lamborg et al. 2008). We will present new results of the 2013 Dutch-led GEOTRACES MEDBlack cruise in the Black Sea. Research vessel "Pelagia" occupied 12 full depth stations along an east-west transect from 13 to 25 July 2013. High resolution vertical profiles were sampled using a titanium ultraclean CTD frame (de Baar et al., 2008) equipped with 24 x 24L PVDF samplers. Samples were filtered (0.2µm, Sartobran 300), drawn into pre-cleaned 250mL Savillex PFA bottles and acidified to 0.4% (v:v) with double-distilled HCl. Dissolved MeHg, as the sum of monomethylHg and dimethylHg, was analyzed via isotope dilution gas chromatography sector field inductively coupled mass spectrometry. Total dissolved Hg was determined following the US EPA 1631 method. We will present high resolution vertical Hg species profiles, including one ultra-high resolution profile (1 sample every 5m-depth) to understand the dynamics along the chemocline (Luther et al., 1991). We will also present the results of the GEOTRACES international intercalibration exercise for dissolved MeHg and dissolved total Hg in surface seawater that we organized during the same cruise. References De Baar HJW, Timmermans KR, Laan P, De Porto HH, Ober S, Blom JJ, Bakker MC, Schilling J, Sarthou G, Smit MG, Klunder M. Titan: A new facility for ultraclean sampling of trace elements and isotopes in the deep oceans in the international Geotraces program. Mar. Chem. 2008, 111

  19. Acute paretic syndrome in juvenile White Leghorn chickens resembles late stages of acute inflammatory demyelinating polyneuropathies in humans

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    Preisinger Rudolf

    2010-01-01

    Full Text Available Abstract Background Sudden limb paresis is a common problem in White Leghorn flocks, affecting about 1% of the chicken population before achievement of sexual maturity. Previously, a similar clinical syndrome has been reported as being caused by inflammatory demyelination of peripheral nerve fibres. Here, we investigated in detail the immunopathology of this paretic syndrome and its possible resemblance to human neuropathies. Methods Neurologically affected chickens and control animals from one single flock underwent clinical and neuropathological examination. Peripheral nervous system (PNS alterations were characterised using standard morphological techniques, including nerve fibre teasing and transmission electron microscopy. Infiltrating cells were phenotyped immunohistologically and quantified by flow cytometry. The cytokine expression pattern was assessed by quantitative real-time PCR (qRT-PCR. These investigations were accomplished by MHC genotyping and a PCR screen for Marek's disease virus (MDV. Results Spontaneous paresis of White Leghorns is caused by cell-mediated, inflammatory demyelination affecting multiple cranial and spinal nerves and nerve roots with a proximodistal tapering. Clinical manifestation coincides with the employment of humoral immune mechanisms, enrolling plasma cell recruitment, deposition of myelin-bound IgG and antibody-dependent macrophageal myelin-stripping. Disease development was significantly linked to a 539 bp microsatellite in MHC locus LEI0258. An aetiological role for MDV was excluded. Conclusions The paretic phase of avian inflammatory demyelinating polyradiculoneuritis immunobiologically resembles the late-acute disease stages of human acute inflammatory demyelinating polyneuropathy, and is characterised by a Th1-to-Th2 shift.

  20. Detection of infectious laryngotracheitis virus by real-time PCR in naturally and experimentally infected chickens.

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    Yan Zhao

    Full Text Available Infectious laryngotracheitis (ILT is an acute, highly contagious upper-respiratory infectious disease of chickens. In this study, a real-time PCR method was developed for fast and accurate detection and quantitation of ILTV DNA of chickens experimentally infected with ILTV strain LJS09 and naturally infected chickens. The detection lower limit of the assay was 10 copies of DNA. There were no cross reactions with the DNA and RNA of infectious bursal disease virus, chicken anemia virus, reticuloendotheliosis virus, avian reovirus, Newcastle disease virus, and Marek's disease virus. The real-time PCR was reproducible as the coefficients of variation of reproducibility of the intra-assay and the inter-assay were less than 2%. The real-time PCR was used to detect the levels of the ILTV DNA in the tissues of specific pathogen free (SPF chickens infected with ILTV at different times post infection. ILTV DNA was detected by real-time PCR in the heart, liver, spleen, lung, kidney, larynx, tongue, thymus, glandular stomach, duodenum, pancreatic gland, small intestine, large intestine, cecum, cecal tonsil, bursa of Fabricius, and brain of chickens in the infection group and the contact-exposure group. The sensitivity, specificity, and reproducibility of the ILTV real-time PCR assay revealed its suitability for detection and quantitation of ILTV in the samples from clinically and experimentally ILTV infected chickens.

  1. Attempts to Save Tragedy in the 19th Century

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    Alicja Przybyszewska

    2013-01-01

    Full Text Available The article outlines the issue of genre-transformation of tragedy in 19th-century Polish drama. The fundamental question is tragedy’s potential after liberation from the most important structural categories of the genre: the three unities, catharsis and anagnorisis. The discussion on the 19th-century patterns of tragedy, derived from contemporary theory, criticism, and theatrical production, are based on research by Marek Dybizbański, who presented an interesting analysis of the problem, which was an important indicator of contemporary literary thought, in his study called Tragedia polska drugiej połowy XIX wieku — wzorce i odstępstwa [The Polish Tragic Drama in Late 19th Century — Patterns and Divergence]. The issues discussed were: disproportion between expectations and effects, indicated by repertoires and contemporary debate on drama, lack of standard productions of tragedy, matched by great surplus of texts that tried to set the standard, and by programmatic declarations on how to do it. The author, following Dybizbański’s discussion, focuses on the question why the 19th century in Poland was, for tragedy, a lost time.

  2. The potential of medical device industry in technological and economical context

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    Maresova P

    2015-10-01

    Full Text Available Petra Maresova,1 Marek Penhaker,1,2 Ali Selamat,1,3 Kamil Kuca1,41Faculty of Informatics and Management, University of Hradec Králové, Hradec Králové, Czech Republic; 2Department of Cybernetics and Biomedical Engineering, Faculty of Electrical Engineering and Computer Science, Technical University of Ostrava, Poruba, Czech Republic; 3Faculty of Computing, Universiti Teknologi Malaysia, Johor Bahru, Johor, Malaysia; 4Center for Biomedical Research, University Hospital Hradec Králové, Hradec Králové, Czech RepublicAbstract: The high quality of public health improves not only healthy life expectancy, but also the productivity of labor. The most important part of the health care sector is the medical technology industry. The aim of this study is to analyze the current situation in the medical device industry in Europe, its potential strengths and weaknesses in the context of topical economic and demographic development. The contribution specifies an analysis of the economic state of the medical device industry in the context of demographic development of European Union’s macroeconomic indicators and views of experts in the field of medical device development, concerning the opportunities for entities involved in the medical device market. There is fierce competition on the European market. The innovative activity is stable and well regulated by responsible authorities. Worldwide, the medical device market is expected to grow.Keywords: technology context, medical device, Europe, expenditure, review

  3. [HUGO STEINHAUS--CO-FOUNDER OF THE LWÓW SCHOOL OF MATHEMATICS].

    Science.gov (United States)

    Wócik, Wiesław

    2014-01-01

    The paper is dedicated to the presentation of professor Hugo Steinhaus--co-founder of the Lwów School of Mathematics. It is indicated that had it not been for the scholar, the founding and development of the Lwów School of Mathematics would have been almost impossible. The analyses focus on his undertakings during the Lvov period in the early 1920s and those events that preceded the founding of the school (namely Steinhaus's education at the Göttingen University, various meetings and gatherings, discussions, first fascinations and mathematical dissertations). This paper, however, does not look into the scientific output of Steinhaus, only presents his method of scientific work and highlights the strategy that he chose in order to create the scientific community. An attempt has been also made to justify the effectiveness of the adopted strategy by describing the scientific atmosphere of Lvov and intellectual potential of the students of the school. Steinhaus's activities in the 1930s will be only marginally presented with an impact on particularly interesting cooperation with the alumni of the Lwów School of Mathematics--Marek Kac, Stefan Kaczmarz, Paweł Nikliborec and scholars from other fields of science (as part of the process of the application of mathematics).

  4. An overview on avian influenza

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    Nelson Rodrigo da Silva Martins

    2012-06-01

    Full Text Available Avian influenza (AI is considered an exotic disease in the Brazilian poultry industry, according to the National Avian Health Program (PNSA, with permanent monitoring of domestic, exotic and native avian species. Brazil presents privileged environmental conditions of reduced risk. In addition, all commercial poultry and conservation holdings are registered in state or national inventories and geographically located (GPS for health control. Poultry health standards are adopted for the conformity to the international market, mostly for the intensified poultry destined for exportation, but also for companion exotic and native conservation facilities. Guidelines for monitoring and the diagnosis of AI are published by the PNSA and follow the standards proposed by the international health code (World Organization for Animal Health, Organization International des Epizooties - OIE and insure the free of status for avian influenza virus (AIV of LPAIV-low pathogenicity AIV and HPAIV-high pathogenicity AIV. In addition, the infections by mesogenic and velogenic Newcastle disease virus, Mycoplasma gallisepticum, M. synoviae and M. meleagridis, Salmonella enteric subspecies enterica serovar Gallinarum biovars Gallinarum and Pullorum are eradicated from reproduction. Controlled infections by S.enterica subspecies enterica serovars Enteritidis and Typhimurium are monitored for breeders. The vaccination of chickens in ovo or at hatch against Marek's disease is mandatory. Broiler production is an indoor activity, confinement which insures biosecurity, with safe distances from the potential AIV reservoir avian species. Worldwide HPAIV H5N1 notifications to the OIE, in March 2011, included 51 countries.

  5. Primary and metastatic tumor dormancy as a result of population heterogeneity.

    Science.gov (United States)

    Kareva, Irina

    2016-08-23

    Existence of tumor dormancy, or cancer without disease, is supported both by autopsy studies that indicate presence of microscopic tumors in men and women who die of trauma (primary dormancy), and by long periods of latency between excision of primary tumors and disease recurrence (metastatic dormancy). Within dormant tumors, two general mechanisms underlying the dynamics are recognized, namely, the population existing at limited carrying capacity (tumor mass dormancy), and solitary cell dormancy, characterized by long periods of quiescence marked by cell cycle arrest. Here we focus on mechanisms that precede the avascular tumor reaching its carrying capacity, and propose that dynamics consistent with tumor dormancy and subsequent escape from it can be accounted for with simple models that take into account population heterogeneity. We evaluate parametrically heterogeneous Malthusian, logistic and Allee growth models and show that 1) time to escape from tumor dormancy is driven by the initial distribution of cell clones in the population and 2) escape from dormancy is accompanied by a large increase in variance, as well as the expected value of fitness-determining parameters. Based on our results, we propose that parametrically heterogeneous logistic model would be most likely to account for primary tumor dormancy, while distributed Allee model would be most appropriate for metastatic dormancy. We conclude with a discussion of dormancy as a stage within a larger context of cancer as a systemic disease. This article was reviewed by Heiko Enderling and Marek Kimmel.

  6. Characteristics of Guinea Fowl Breeding in West Africa: A Review

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    Houndonougbo, PV.

    2017-01-01

    Full Text Available Guinea fowl production in sub-Saharan Africa (SSA is generally practiced under family and traditional rearing systems mainly for consumption and income generation, but this species plays also a major socio-cultural role in specific ceremonies. Birds are kept in free range or in confinement with outdoor access and fed on grain cereals, vegetables, edible termites and kitchen residues found in nature or occasionally supplied by the farmers. Several Guinea fowl varieties are observed and all are characterized by slow growth, high mortality of young animals and a relatively wild instinct. Although this avian species is resistant to some poultry diseases (Newcastle disease, Marek disease, Gumboro disease, ..., local guinea fowl are very sensitive to other poorly controlled diseases that require further study. These varieties differ greatly by their feather color, their morphological characteristics and growth performance, but further thorough and sustained research is needed to quantify these differences. Several researches established the nutritional requirements of local Guinea fowl but in terms of breeding, little works were done compared to chicken. Some recessive and dominant genes as well as genotypic differences were highlighted between varieties.

  7. Two diagnoses become one? Rare case report of anorexia nervosa and Cushing’s syndrome

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    Sawicka N

    2013-03-01

    Full Text Available Nadia Sawicka,* Maria Gryczyńska,* Jerzy Sowiński, Monika Tamborska-Zedlewska, Marek Ruchała Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland*These authors contributed equally to this workAbstract: Hypothalamic-pituitary-adrenal axis impairment in anorexia nervosa is marked by hypercortisolemia, and psychiatric disorders occur in the majority of patients with Cushing’s syndrome. Here we report a patient diagnosed with anorexia nervosa who also developed Cushing’s syndrome. A 26-year-old female had been treated for anorexia nervosa since she was 17 years old, and also developed depression and paranoid schizophrenia. She was admitted to the Department of Endocrinology, Metabolism, and Internal Medicine with a preliminary diagnosis of Cushing’s syndrome. Computed tomography revealed a 27 mm left adrenal tumor, and she underwent laparoscopic adrenalectomy. She was admitted to hospital 6 months after this procedure, at which time she did not report any eating or mood disorder. This is a rare case report of a patient with anorexia nervosa in whom Cushing’s syndrome was subsequently diagnosed. Diagnostic difficulties were caused by the signs and symptoms presenting in the course of both disorders, ie, hypercortisolemia, osteoporosis, secondary amenorrhea, striae, hypokalemia, muscle weakness, and depression.Keywords: anorexia nervosa, Cushing’s syndrome, adrenalectomy, osteoporosis

  8. Establishment and characterization of a chicken mononuclear cell line.

    Science.gov (United States)

    Qureshi, M A; Miller, L; Lillehoj, H S; Ficken, M D

    1990-11-01

    A new chicken mononuclear cell line (MQ-NCSU) has been established. The starting material used to initiate this cell line was a transformed spleen from a female Dekalb XL chicken which had been experimentally challenged with the JM/102W strain of the Marek's disease virus. After homogenization, a single cell suspension of splenic cells was cultured using L.M. Hahn medium supplemented with 10 microM 2-mercaptoethanol. Under these culture conditions, a rapidly proliferating cell was observed and then expanded after performing limiting dilution cultures. These cells were moderately adherent and phagocytic for sheep red blood cells and Salmonella typhimurium. When tested against a panel of monoclonal antibodies (mAb) using the flow cytometry, MQ-NCSU cells stained readily with anti-chicken monocyte specific (K-1) mAb but did not stain with mAb detecting T-helper, T-cytotoxic/suppressor, and NK cells. MQ-NCSU cells expressed very high levels of Ia antigens and transferrin receptors. In addition, cell-free supernatant obtained from MQ-NCSU culture contained a factor which exhibited cytolytic activity against tumor cell targets. Based on their cultural, morphological, and functional characteristics and mAb reactivity profile, we conclude that MQ-NCSU cell line represents a malignantly-transformed cell which shares features characteristic of cells of the mononuclear phagocyte lineage.

  9. Melting hadrons, boiling quarks from Hagedorn temperature to ultra-relativistic heavy-ion collisions at CERN : with a tribute to Rolf Hagedorn

    CERN Document Server

    2015-01-01

    This book shows how the study of multi-hadron production phenomena in the years after the founding of CERN culminated in Hagedorn's pioneering idea of limiting temperature, leading on to the discovery of the quark-gluon plasma - announced, in February 2000 at CERN. Following the foreword by Herwig Schopper -- the Director General (1981-1988) of CERN at the key historical juncture -- the first part is a tribute to Rolf Hagedorn (1919-2003) and includes contributions by contemporary friends and colleagues, and those who were most touched by Hagedorn: Tamás Biró, Igor Dremin, Torleif Ericson, Marek Gázdzicki, Mark Gorenstein, Hans Gutbrod, Maurice Jacob, István Montvay, Berndt Müller, Grazyna Odyniec, Emanuele Quercigh, Krzysztof Redlich, Helmut Satz, Luigi Sertorio, Ludwik Turko, and Gabriele Veneziano. The second and third parts retrace 20 years of developments that after discovery of the Hagedorn temperature in 1964 led to its recognition as the melting point of hadrons into boiling quarks, and t...

  10. 103rd Meeting of the SPSC

    CERN Multimedia

    Morna Robillard

    2011-01-01

    from Tuesday 25 October 2011 at 09:00 to Wednesday 26 October 2011 at 16:00 Council Chamber, Bldg. 503 News from the Non-LHC Experiments at CERN Claude Vallee / CPPM Marseille Tuesday 25 October 2011 09:00 - 13:00 OPEN SESSION 09:00 Status and plans of the NA61 experiment 30' Speaker:  Marek Gazdzicki / Johann-Wolfgang-Goethe Univ. (DE) 09:40 Status and plans of the NA63 experiment 20' Speaker:  Ulrik Uggerhoj 10:10 Status and plans of the CAST experiment 30' Speaker:  Esther Ferrer Ribas / IRFU/CEA-Saclay 10:50 Coffee Break 20' 11:10 Status and plans of the OSQAR experiment 30' Speaker:  Pierre Pugnat / CNRS - LNCMI-G (Laboratoire National des Champs Magnétiques Intenses de Grenoble 11:50 Status and plans of the UA9 experiment 20' Speaker:  Walter Scandale / Universite de Paris-Sud 11 (FR) 12:20 A proposal to measure the gravitational behaviour of antihydrogen at rest 30' Speaker:  Patr...

  11. Health evaluation of Galapagos Hawks (Buteo galapagoensis) on Santiago Island, Galapagos.

    Science.gov (United States)

    Deem, Sharon L; Rivera-Parra, Jose Luis; Parker, Patricia G

    2012-01-01

    Galapagos Hawks (Buteo galapagoensis), the only endemic, diurnal raptor species in Galapagos, are currently distributed on eight Galapagos Islands having been extirpated from three of the human-inhabited islands. In January 2009, we performed health assessments of 89 Galapagos Hawks on Santiago Island, Galapagos. Four of the 89 Galapagos Hawks (4%) evaluated had physical abnormalities. Blood parameters did not differ between males and females, except for aspartate transaminase values, which were significantly higher in females than males. No Galapagos Hawks tested positive for antibodies to avian encephalitis virus, Marek virus, and paramyxovirus-1 or to haemosporidian antigen. Chlamydophila psittaci antigen was detected in 2 of 86 Galapagos Hawks (2%), with 24 of 43 Galapagos Hawks (56%) antibody-positive for avian adenovirus-1 and 1 of 48 Galapagos Hawks (2%) antibody positive for Toxoplasma gondii. There were no significant differences in infectious disease results based on sex. This study contributes to the understanding of the health status of the Galapagos Hawk and to the establishment of baseline information for the species.

  12. Evolution of viral virulence: empirical studies

    Science.gov (United States)

    Kurath, Gael; Wargo, Andrew R.

    2016-01-01

    The concept of virulence as a pathogen trait that can evolve in response to selection has led to a large body of virulence evolution theory developed in the 1980-1990s. Various aspects of this theory predict increased or decreased virulence in response to a complex array of selection pressures including mode of transmission, changes in host, mixed infection, vector-borne transmission, environmental changes, host vaccination, host resistance, and co-evolution of virus and host. A fundamental concept is prediction of trade-offs between the costs and benefits associated with higher virulence, leading to selection of optimal virulence levels. Through a combination of observational and experimental studies, including experimental evolution of viruses during serial passage, many of these predictions have now been explored in systems ranging from bacteriophage to viruses of plants, invertebrates, and vertebrate hosts. This chapter summarizes empirical studies of viral virulence evolution in numerous diverse systems, including the classic models myxomavirus in rabbits, Marek's disease virus in chickens, and HIV in humans. Collectively these studies support some aspects of virulence evolution theory, suggest modifications for other aspects, and show that predictions may apply in some virus:host interactions but not in others. Finally, we consider how virulence evolution theory applies to disease management in the field.

  13. Expression of the env gene from the avian endogenous retrovirus ALVE and regulation by miR-155.

    Science.gov (United States)

    Hu, Xuming; Zhu, Wenqi; Chen, Shihao; Liu, Yangyang; Sun, Zhen; Geng, Tuoyu; Wang, Xiaoyan; Gao, Bo; Song, Chengyi; Qin, Aijian; Cui, Hengmi

    2016-06-01

    Endogenous retroviruses (ERVs) are important retroelements that reside in host genomes. However, ERV expression patterns and regulatory mechanisms are poorly understood. In this study, chicken embryo fibroblasts (CEFs) and MSB1 cells infected with Marek's disease virus (MDV) exhibited significantly increased expression of env from the endogenous retrovirus ALVE. In contrast, env expression was significantly lower in CEF and MSB1 cells infected with exogenous avian leukosis virus J (ALVJ) at the early infection stage. Furthermore, env was found to be ubiquitously expressed in various chicken tissues, with high expression in certain tissues at 2 days of age and low levels in most tissues, including immune organs (thymus, spleen and bursa) as well as the brain and heart, at 35 days of age. Sequence analysis revealed miR-155 target sites in env transcripts, which was verified using a firefly luciferase reporter assay, and treatment with miR-155 agomir significantly decreased levels of env transcripts in MSB1 and CEF cells. Together, these findings suggest that the env gene from the endogenous retrovirus ALVE is regulated by miR-155.

  14. Vacuum chambers full of ideas for the Swedish synchrotron

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    CERN’s Vacuum, Surfaces and Coatings group has contributed to the development of vacuum chambers for the MAX IV synchrotron, which has just been officially opened in Sweden.   A section of the new 3 GeV MAX IV synchrotron at the time of installation. In the centre of the magnets you can see the vacuum chamber developed in collaboration with CERN. (Photo: Marek Grabski, MAX IV Vacuum group) On 21 June, the King and the Prime Minister of Sweden officially opened MAX IV, a brand-new synchrotron in Lund, Sweden. The summer solstice, the longest day of the year, was deliberately chosen for the ceremony: MAX IV, a cutting-edge synchrotron, will deliver the brightest X-rays ever produced to more than 2000 users. Some 1500 kilometres away, a team at CERN followed the opening ceremony with a touch of pride. The Vacuum, Surfaces and Coatings group in the Technology department (TE-VSC) participated in the construction of this new synchrotron. Its contribution lies at the very hea...

  15. Developing computer-based training programs for basic mammalian histology: Didactic versus discovery-based design

    Science.gov (United States)

    Fabian, Henry Joel

    Educators have long tried to understand what stimulates students to learn. The Swiss psychologist and zoologist, Jean Claude Piaget, suggested that students are stimulated to learn when they attempt to resolve confusion. He reasoned that students try to explain the world with the knowledge they have acquired in life. When they find their own explanations to be inadequate to explain phenomena, students find themselves in a temporary state of confusion. This prompts students to seek more plausible explanations. At this point, students are primed for learning (Piaget 1964). The Piagetian approach described above is called learning by discovery. To promote discovery learning, a teacher must first allow the student to recognize his misconception and then provide a plausible explanation to replace that misconception (Chinn and Brewer 1993). One application of this method is found in the various learning cycles, which have been demonstrated to be effective means for teaching science (Renner and Lawson 1973, Lawson 1986, Marek and Methven 1991, and Glasson & Lalik 1993). In contrast to the learning cycle, tutorial computer programs are generally not designed to correct student misconceptions, but rather follow a passive, didactic method of teaching. In the didactic or expositional method, the student is told about a phenomenon, but is neither encouraged to explore it, nor explain it in his own terms (Schneider and Renner 1980).

  16. Beyond Turing: mechanochemical pattern formation in biological tissues.

    Science.gov (United States)

    Mercker, Moritz; Brinkmann, Felix; Marciniak-Czochra, Anna; Richter, Thomas

    2016-05-04

    During embryogenesis, chemical (morphogen) and mechanical patterns develop within tissues in a self-organized way. More than 60 years ago, Turing proposed his famous reaction-diffusion model for such processes, assuming chemical interactions as the main driving force in tissue patterning. However, experimental identification of corresponding molecular candidates is still incomplete. Recent results suggest that beside morphogens, also tissue mechanics play a significant role in these patterning processes. Combining continuous finite strain with discrete cellular tissue models, we present and numerically investigate mechanochemical processes, in which morphogen dynamics and tissue mechanics are coupled by feedback loops. We consider three different mechanical cues involved in such feedbacks: strain, stress, and compression. Based on experimental results, for each case, we present a feedback loop spontaneously creating robust mechanochemical patterns. In contrast to Turing-type models, simple mechanochemical interaction terms are sufficient to create de novo patterns. Our results emphasize mechanochemical processes as possible candidates controlling different steps of embryogenesis. To motivate further experimental research discovering related mechanisms in living tissues, we also present predictive in silicio experiments. Reviewer 1 - Marek Kimmel; Reviewer 2 - Konstantin Doubrovinski (nominated by Ned Wingreen); Reviewer 3 - Jun Allard (nominated by William Hlavacek).

  17. Animal genomics and infectious disease resistance in poultry.

    Science.gov (United States)

    Smith, J; Gheyas, A; Burt, D W

    2016-04-01

    Avian pathogens are responsible for major costs to society, both in terms of huge economic losses to the poultry industry and their implications for human health. The health and welfare of millions of birds is under continued threat from many infectious diseases, some of which are increasing in virulence and thus becoming harder to control, such as Marek's disease virus and avian influenza viruses. The current era in animal genomics has seen huge developments in both technologies and resources, which means that researchers have never been in a better position to investigate the genetics of disease resistance and determine the underlying genes/mutations which make birds susceptible or resistant to infection. Avian genomics has reached a point where the biological mechanisms of infectious diseases can be investigated and understood in poultry and other avian species. Knowledge of genes conferring disease resistance can be used in selective breeding programmes or to develop vaccines which help to control the effects of these pathogens, which have such a major impact on birds and humans alike.

  18. Essay and Ekphrasis (Herbert - Bieńkowska - Bieńczyk

    Directory of Open Access Journals (Sweden)

    Roma Sendyka

    2009-01-01

    Full Text Available Michel Riffaterre in article L'lllusion d'ekphrasis put forward an idea of "critical ekphrasis" (1994 what may become an invitation to ask if other sub-genres/modes of ekphrasis may be described. The text Essay and Ekphrasis develops this question in the field of essayistic traditions. Evoking the tendency of writing on art in that genre (from Montaigne, Diderot, Ruskin, Pater to art historians, critics and artists the article analyses three examples of ekphrases (by Zbigniew Herbert, Ewa Bieńkowska and Marek Bieńczyk to voice a hypothesis that ekphrasis in an essay may be a useful proof for those who question (ostensive representational powers of that textual tool. Essayistic ekphrasis seems to have a foremost referential character, pointing towards an object of art only to use it in order to describe cognitive procedures of the subject who in such a way (performatively and not overtly pictures himself mirroring his inner self in dispersed fragments of cultural object, dismantling the temporal and spatial difference between the viewer and the object in an illusion of an immediate presence.

  19. Development, characterization and optimization of a new suspension chicken-induced pluripotent cell line for the production of Newcastle disease vaccine.

    Science.gov (United States)

    Shittu, Ismaila; Zhu, Ziying; Lu, Yangqing; Hutcheson, Jessica M; Stice, Steven L; West, Franklin D; Donadeu, Meritxell; Dungu, Baptiste; Fadly, Aly M; Zavala, Guillermo; Ferguson-Noel, Naola; Afonso, Claudio L

    2016-01-01

    Traditionally, substrates for production of viral poultry vaccines have been embryonated eggs or adherent primary cell cultures. The difficulties and cost involved in scaling up these substrates in cases of increased demand have been a limitation for vaccine production. Here, we assess the ability of a newly developed chicken-induced pluripotent cell line, BA3, to support replication and growth of Newcastle disease virus (NDV) LaSota vaccine strain. The characteristics and growth profile of the cells were also investigated. BA3 cells could grow in suspension in different media to a high density of up to 7.0 × 10(6) cells/mL and showed rapid proliferation with doubling time of 21 h. Upon infection, a high virus titer of 1.02 × 10(8) EID50/mL was obtained at 24 h post infection using a multiplicity of infection (MOI) of 5. In addition, the cell line was shown to be free of endogenous and exogenous Avian Leukosis viruses, Reticuloendotheliosis virus, Fowl Adenovirus, Marek's disease virus, and several Mycoplasma species. In conclusion, BA3 cell line is potentially an excellent candidate for vaccine production due to its highly desirable industrially friendly characteristics of growing to high cell density and capability of growth in serum free medium. Published by Elsevier Ltd.

  20. Influence of sulfur amino acid levels in diets of broiler chickens submitted to immune stress

    Directory of Open Access Journals (Sweden)

    LL Rubin

    2007-03-01

    Full Text Available Several changes in amino acid levels occur during an infection. As a rule, glycine, taurine and serine levels diminish considerably, while cysteine levels increase. Such changes may be attributed to the intense consumption of sulfur amino acids (SAA- methionine+cysteine during infectious challenge. Methionine plays an important role in humoral and cellular immune responses. It has been suggested that such effect is exerted by intracellular glutathione and cysteine levels. Four-hundred thirty-two day-old Ross male broiler chickens were fed (from 1 to 42 days of age three SAA levels in the diet (0.72, 0.82, and 0.92% from 1 to 21 days of age; 0.65, 0.75, and 0.85% from 22 to 42 days of age and submitted to two immunological stimulus series. Vaccines against Marek's disease, Fowlpox, Infectious Bronchitis and Infectious Bursal disease, Freund's Complete Adjuvant, and avian tuberculin were used as immunological stimuli. The experiment comprised 6 treatments, with 6 replications using 12 birds per replicate. Performance data were collected weekly. Gumboro antibodies were measured by ELISA, and the cellular immune response by the tuberculin test. SAA levels tested did not influence immune response. Nevertheless, the vaccines applied on the 1st day impaired chick performance up to the 21 days of age. The SAA levels generally adopted in poultry husbandry may not be enough to assure weight gain, especially when birds are raised if a low-challenge infectious environment.

  1. A Concise Dictionary of Transparency

    Directory of Open Access Journals (Sweden)

    Jakub Misun

    2013-01-01

    Full Text Available The article discusses an essay collection by Marek Bieńczyk, Przeźroczystość [Transparency]. The concept, placed in various context, shows various aspects and is seen in various shades. The author does not put forward a statement, but rather proposes a work to be done: to determine the modality of transparency. The concept initially seems to be mainly epistemological: the cognizant subject would like to make the world transparent, to discover all possible mysteries. Before that, however, the subject must know itself, and here the dream of trans­parency also plays the key role. Lack of epistemological transparency is the main cause of melancholy and its reverse — hysteria. The concept turns out to be important in the domain of love — the loer thinks that (she knows the desired person more better anybody else, that (she has entirely penetrated the subjectivity of the Other. Ultimately, however, the dream of transparency goes down to a slow demise of the subject: as self-discovery progresses, there is less and less of the discoverer. In conclusion of this work, the border of modality of the concept turns out to be horrifyingly obvious. The desire for transparency consequently searches not for knowledge, but for an escape whose name is death.

  2. Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens.

    Science.gov (United States)

    Zhang, Jianhua; Chen, Yong; Qi, Jianxun; Gao, Feng; Liu, Yanjie; Liu, Jun; Zhou, Xuyu; Kaufman, Jim; Xia, Chun; Gao, George F

    2012-11-01

    The MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic MHC molecules to T lymphocytes of the immune system. In chickens, only a single classical class I molecule in each MHC haplotype is expressed well due to coevolution with the polymorphic TAPs which means that resistance and susceptibility to infectious pathogens are particularly easy to observe. Previously, structures of chicken MHC class I molecule BF2*2101 from B21 haplotype showed an unusually large peptide-binding groove that accommodates a broad spectrum of peptides to present as epitopes to CTLs, explaining the MHC-determined resistance of B21 chickens to Marek's disease. In this study, we report the crystal structure of BF2*0401 from the B4 (also known as B13) haplotype, showing a highly positively charged surface hitherto unobserved in other MHC molecules, as well as a remarkably narrow groove due to the allele-specific residues with bulky side chains. Together, these properties limit the number of epitope peptides that can bind this class I molecule. However, peptide-binding assays show that in vitro, BF2*0401 can bind a wider variety of peptides than are found on the surface of B4 cells. Thus, a combination of the specificities of the polymorphic TAP and the MHC results in a very limited set of BF2*0401 peptides with negatively charged anchors to be presented to T lymphocytes.

  3. Proxemics: A study on cultural anthropology

    Directory of Open Access Journals (Sweden)

    Marek Hendrykowski

    2015-11-01

    Full Text Available Marek Hendrykowski’s study deals with the semiotics of interpersonal proxemic relationships in today’s world. When analyzing this issue, the author puts forward three research hypotheses. First, interpersonal relationships that are connected with social space are not on the margins of systems of culture, but constitute a very important characteristic of each such system. Secondly, the traditional ways of defining proxemics, which emphasize the existence of interpersonal barriers,present the complex issues related to this field of science of signs and meanings too narrowly and usually in a schematic manner. And thirdly, the profound changes in proxemic relationships that are taking place in the macrosystem of contemporary culture have a major influence on the functioning of culture itself as well as on how individuals, groups and communities participate in this culture. When analyzed in terms of the proxemics of interpersonal relationships, the cultural ecosystem is not an abstract model but an operating system which governs the daily living conditionsof individuals, groups and communities.

  4. Czy neopragmatyzm jest transcendentalizmem? Rozważania na tle filozofii Richarda Rorty’ego i Roberta Brandoma [Is Neopragmatism Transcendentalism? Considerations in the Background of the Philosophy of Robert Brandom and Richard Rorty

    Directory of Open Access Journals (Sweden)

    Daniel Żuromski

    2012-12-01

    Full Text Available The subject of this paper is one of the central problems of philosophy, which isaptly stated by Hilary Putnam: “How does mind/language hook on to the world?”.This question presupposes a model of knowledge which may be called “the subject--object model of knowledge”. However, contemporary philosophers such as WilfridSellars, Hilary Putnam, Donald Davidson, Richard Rorty, John McDowell, JohnHaugeland and Robert Brandom criticize this traditional model of knowledge. I claimthat at least some versions of neopragmatism look at this problem implicitly assum-ing a transcendental point of view. This istranscendentalism without transcendentalstandpointand can be found in Marek Siemek’s works. This transcendentalismcan be considered in two ways. First, as a therapy – a standpoint that is characteristicof Rorty, who demonstrated that the subject-object model of knowledge is optionaland contingent. Second, as constructivism – this standpoint is represented by Bran-dom, who tries to show that this traditional model is not autonomus.

  5. Common occurrence of Gallid herpesvirus-2 with reticuloendotheliosis virus in chickens caused by possible contamination of vaccine stocks.

    Science.gov (United States)

    Woźniakowski, G; Mamczur, A; Samorek-Salamonowicz, E

    2015-04-01

    The aim of this study was to investigate the common occurrence of reticuloendotheliosis virus (REV) among Gallid herpesvirus 2 (GaHV-2) infected chickens. The possible cause of this co-occurrence may be linked to contaminated vaccine stocks, which were also examined. The study was conducted on 25 field isolates of GaHV-2 collected between 2007 and 2013 from vaccinated chickens. Additionally, 10 commercial Marek's Disease vaccine stocks manufactured between 1993 and 2013, comprising of FC126 HVT, CVI988/Rispens and bivalent HVT + Rispens vaccines were examined. Chicken isolates were collected from the liver. Due to difficulties in differentiation between GaHV-2 and REV, by observation of clinical signs or lesions presented in liver or spleen, loop-mediated isothermal amplification (LAMP and RT-LAMP) as well as PCR-based methods were applied. The co-occurrence of GaHV-2 and REV genetic material was shown in 24 (96%) of 25 examined isolates. A marginal REV contamination was detected in three out 10 (30%) commercial vaccine stocks, mainly in bivalent HVT + Rispens vaccines produced between 2009 and 2012. Our results indicated the common occurrence of GaHV-2 and REV in Polish chicken flocks, which is probably linked to contaminated HVT + Rispens vaccine stocks. Reasons for the detection of a marginal REV contamination need to be further elucidated. © 2014 The Society for Applied Microbiology.

  6. Relativistic Astrophysics

    Science.gov (United States)

    Jones, Bernard J. T.; Markovic, Dragoljub

    1997-06-01

    Preface; Prologue: Conference overview Bernard Carr; Part I. The Universe At Large and Very Large Redshifts: 2. The size and age of the Universe Gustav A. Tammann; 3. Active galaxies at large redshifts Malcolm S. Longair; 4. Observational cosmology with the cosmic microwave background George F. Smoot; 5. Future prospects in measuring the CMB power spectrum Philip M. Lubin; 6. Inflationary cosmology Michael S. Turner; 7. The signature of the Universe Bernard J. T. Jones; 8. Theory of large-scale structure Sergei F. Shandarin; 9. The origin of matter in the universe Lev A. Kofman; 10. New guises for cold-dark matter suspects Edward W. Kolb; Part II. Physics and Astrophysics Of Relativistic Compact Objects: 11. On the unification of gravitational and inertial forces Donald Lynden-Bell; 12. Internal structure of astrophysical black holes Werner Israel; 13. Black hole entropy: external facade and internal reality Valery Frolov; 14. Accretion disks around black holes Marek A. Abramowicz; 15. Black hole X-ray transients J. Craig Wheeler; 16. X-rays and gamma rays from active galactic nuclei Roland Svensson; 17. Gamma-ray bursts: a challenge to relativistic astrophysics Martin Rees; 18. Probing black holes and other exotic objects with gravitational waves Kip Thorne; Epilogue: the past and future of relativistic astrophysics Igor D. Novikov; I. D. Novikov's scientific papers and books.

  7. Herpesviruses and Newcastle disease viruses in white storks (Ciconia ciconia).

    Science.gov (United States)

    Kaleta, E F; Kummerfeld, N

    1983-01-01

    Three herpesviruses were isolated from white storks (Ciconia ciconia). All isolates reacted in cross-neutralisation tests with homologous antisera and with sera prepared against a herpesvirus from a black stork (Ciconia nigra). These data indicate serologic relatedness of the herpesviruses from both stork species. Antisera prepared against herpesviruses from the domestic chicken (viruses of Marek's disease and infectious laryngotracheitis), turkey, duck and pigeon as well as from the blue-fronted amazon (Amazona aestiva), prairie falcon (Falco mexicanus), eagle owl (Bubo bubo), Lake Victoria cormorant (Phalacrocorax melanoleucos), bobwhite quail (Colinus virginianus) and desmoiselle crane (Anthropoides virgo) did not react with the stork herpesviruses. Neutralising antibodies against stork herpesvirus were detected in the majority of 72 blood samples from white and black storks. In addition, three Newcastle disease viruses (NDV) could be isolated from white storks. One isolate was highly virulent the two others were avirulent for the chicken. Haemagglutination inhibition tests have shown that some storks have antibodies against Paramyxovirus- (PMV)-1 (NDV), PMV-2 and PMV-3. No antibodies could be detected in stork sera against PMV-4, -6 and -7.

  8. Mammalian and avian embryology at Warsaw University (Poland) from XIX century to the present.

    Science.gov (United States)

    Tarkowski, Andrzej K; Maleszewski, Marek; Rogulska, Teresa; Ciemerych, Maria A; Borsuk, Ewa

    2008-01-01

    In this article, we describe the history (between the XIX century and World War II) of embryological research conducted at Warsaw University, together with current research activities being carried out at the Department of Embryology. During the partition of Poland, the Imperial (Russian) Warsaw University conducted research on avian embryology (and to a smaller extent, on reptilian embryology). When Poland regained independence in 1918, these studies were continued under the Chair of Comparative Anatomy headed by Professor Jan Tur. A new Department of Embryology created in 1954 was first headed by Professor Stanislaw Bilewicz and since 1964 by Professor Andrzej Tarkowski, who in 2003 was succeeded by Dr. Marek Maleszewski D.Sc. During the last 45 years, embryological research at Warsaw University has concentrated mainly on mammalian development with special emphasis on the regulative capabilities of early embryos and also on experimental chimaeras, nucleo-cytoplasmic interactions in oogenesis and early embryogenesis (including regulation of DNA replication and transcription), experimental parthenogenesis and fertilization.

  9. LHC gets the ball rolling

    CERN Multimedia

    2007-01-01

    A technique involving a small ball with a transmitter embedded inside it has been successfully tested in Sector 7-8. The ball is sent through the LHC beam pipes to check the LHC interconnections. The multidisciplinary team responsible for the RF ball project to check the interconnections. From left to right: Rhodri Jones (AB/BI), Eva Calvo (AB/BI), Francesco Bertinelli (AT/MCS), Sonia Bartolome Jimenez (TS/IC), Sylvain Weisz (TS/IC), Paul Cruikshank (AT/VAC), Willemjan Maan (AT/VAC), Alain Poncet (AT/MCS), Marek Gasior (AB/BI). During the tests the ball is inserted very carefully into the vacuum chamber.A game of ping-pong at the LHC? On 13 September a rather unusual test was carried out in Sector 7-8 of the accelerator. A ball just a bit smaller than a ping-pong ball was carefully introduced into one of the accelerator’s two vacuum pipes, where it travelled 800 metres in the space of a few mi...

  10. „Ósmy dzień tygodnia”

    Directory of Open Access Journals (Sweden)

    Anna Zawadzka

    2012-12-01

    Full Text Available “The Eighth Day of the Week” The Eighth Day of the Week is a short story by Marek Hłasko revolving around the topic of losing virginity. Literary scholars consider Hłasko as a representative of machismo; a masculine and male-centred narrator. This text analyses and deconstructs the short story defending it as a comprehensive record of misogynist culture written from the perspective of the main female protagonist and not the expression of misogyny of the author himself. The tools of discourse analysis and feminist philosophy applied to Hłasko’s text produce surprising results. Agnieszka – the main female protagonist of the short story – turns out to be a figure of non-conformity universalised by Hłasko, while the virginity and its loss become a part of female fate used by Hłasko as a motif to show the power of society over an individual. Meanwhile Agnieszka struggles for autonomy from domineering cultural patterns and gains it with the help of not so much barricades and spectacular gestures typical for male protagonists as wit, intelligence and trickery.

  11. PREFACE: Joint European Magnetic Symposia - JEMS 2010

    Science.gov (United States)

    Spałek, Jozef

    2011-07-01

    łekChairman of JEMS 2010 Symposia 1. Plenary, Semi-plenary, Tutorials 2. Magnetization Processes Spin Excitations and Ultrafast DynamicsCoordinator: Andrzej Maziewski (Bialystok) 3. Hard Magnetic Materials and MagnetocaloricsCoordinator: Henryk Figiel (Kraków) 4. Magnetic HydridesCoordinators: Ladislav Havela (Praha), Zbigniew Tarnawski (Kraków) 5. Interface of Magnetic Thin FilmsCoordinators: Jürgen Fassbender (Dresden), N-T H Kim-Ngan (Kraków) 6. Magnonic CrystalsCoordinators: Bahram Djafari-Rouhani (Lille), Henryk Puszkarski (Poznan) 7. Magnetism of Metals, Alloys, and IntermetallicsCoordinator: Andrzej Szytula (Kraków) 8. Molecular MagnetismCoordinators: Stephen Blundell (Oxford), Maria Balanda (Kraków) 9. Magnetooptics of NanomagnetsCoordinators: Kamil Postava (Ostrava), Marek Kisielewski (Bialystok) 10. NanomagnetismCoordinators: Marek Przybylski (Halle), Jürgen Kirschner (Halle) 11. Other topics - Biomagnetism, Domain Walls, InstrumentationCoordinator: Henryk Figiel (Kraków) 12. Magnetic Perovskites and MultiferroicsCoordinator: Henryk Szymczak (Warszawa) 13. Magnetic Semiconductors and InsulatorsCoordinators: Klaus Baerner (Göttingen), Tadeusz Gron (Katowice) 14. Magnetic Shape Memory Effects and Related PhenomenaCoordinators: Oliver Gutfleisch (Dresden), Sebastian Fähler (Dresden) 15. Soft Magnetic MaterialsCoordinators: Julian González (San Sebastian), Krzysztof Kulakowski (Kraków) 16. SpintronicsCoordinator: Maciej Sawicki (Warszawa) 17. Strongly Correlated Electron Systems, Magnetism and SuperconductivityCoordinator: Andrzej Slebarski (Katowice) The next Joint European Magnetic Symposia, JEMS 2012, will be held in Parma, Italy, 9-14 September 2012.www.jems2012.itCo-Chairs:Franca Albertini, Institute of Materials for Electronics and Magnetism (IMEM), CNR, ParmaRoberto De Renzi, Department of Physics, University of Parma

  12. Gp85 genetic diversity of avian leukosis virus subgroup J among different individual chickens from a native flock.

    Science.gov (United States)

    Li, Yang; Fu, Jiayuan; Cui, Shuai; Meng, Fanfeng; Cui, Zhizhong; Fan, Jianhua; Chang, Shuang; Zhao, Peng

    2017-05-01

    To compare the genetic diversity and quasispecies evolution of avian leukosis virus (ALV) among different individuals, 5 chickens, raised in Shandong Provice of China, were randomly selected from a local chicken flock associated with serious tumor cases. Blood samples were collected and inoculated into chicken embryo fibroblast and DF-1 cell lines for virus isolation and identification, respectively, of Marek's disease virus (MDV), reticuloendotheliosis virus (REV), and ALV. Five strains of ALV subgroup J (ALV-J) were identified, and the gp85 gene from each strain was amplified and cloned. For each strain, about 20 positive clones of gp85 gene were selected for sequence analyses and the variability of the quasispecies of the 5 strains was compared. The results showed that the nuclear acid length of gp85 gene of 5 ALV-J isolates is 921 bp, 921 bp, 924 bp, 918 bp, and 912 bp respectively, and amino acid homologies of different gp85 clones from the 5 ALV-J strains were 99.3 to 100%, 99.3 to 100%, 99.4 to 100%, 98.4 to 100%, 99.0 to 100%, respectively. The proportions of dominant quasispecies were 65.0%, 85.0%, 85.0%, 50.0%, 84.2%, respectively, and homology of the gp85 among these dominant quasispecies was 89.2 to 92.5%. These data demonstrated the composition of the ALV-J quasispecies varied among infected individuals even within the same flock, and the dominant quasispecies continued to evolve both for their proportion and gene mutation. © 2016 Poultry Science Association Inc.

  13. Nowe wymiary tożsamości – media, kultura popularna, rzeczywistość cyfrowa

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    Wojciech Baluch

    2016-06-01

    Full Text Available The text concentrates on the issue of identity and its transformations, driven by the spread of media and digital culture. In the first part it presents three canonic proposals for reflections on virtual identity. Firstly, reflections on the communication dimension of identity derived from Martin Buber’s philosophy of dialog. Secondly, the concept of “ontological shift” as suggested by Marek Krajewski, who sees in it the remedy for the lack of a real dimension of many virtual contacts. Thirdly, the issues of the integrity of the individual and the fluidity of modern reality in the approaches proposed by Wolfgang Welsh, Anthony Giddens, and Zygmunt Bauman. The analytical part contains an analysis of the important aspects of the notion of identity. The first is the issue of the subjectivity of an utterance and its source, which will be discussed using the example of a play based on texts that adapted from Internet blogs. The second issue is an attempt to answer the question posed by Sherry Turkle of whether if it is possible to kill someone virtually. The point of reference for the search for a solution to this issue is the popular computer game “Vampire”.The last aspect has to do with celebrity identity in the media world. This concerns the phenomenon of celebrities in the pragmatic dimension as a model strategy of behaviour in the world, in which the boundary between privacy and public space has been blurred. On the basis of these analyses, which cover merely a small part of human experience, the author proposes a new methodological approach to perceiving and analysing aspects of identity revealed through the confrontation with the new virtual reality.

  14. Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model

    Directory of Open Access Journals (Sweden)

    Webb Glenn

    2011-01-01

    article was reviewed by Leonid Hanin, Anna Marciniak-Czochra and Marek Kimmel.

  15. Subsoil methanogenesis as source of stem CH4 emission in upland forest trees: preferential CH4 transport via the root system?

    Science.gov (United States)

    Maier, M.; Machacova, K.; Urban, O.; Friederike, L.

    2016-12-01

    Quantifying and understanding green house gas fluxes in natural soil-plant-atmosphere systems are crucial to predicting global climate change. Wetland species or trees at waterlogged sites are known to emit large amounts of CH4. Yet upland forest soils are regarded as CH4 sinks and tree species like upland European beech (Fagus sylvatica, L.) are assumed not to emit CH4. We studied the soil-atmosphere and stem-atmosphere fluxes of CH4, and soil gas profiles at two upland beech forest sites in Central Europe. Soil was a net CH4 sink at both. Unusually there was one beech tree with substantial CH4 emissions that were higher than the CH4 sink of the soil. The soil gas profile at this tree indicated CH4 production at a soil depth >0.3 m, despite the net uptake of CH4 observed at the soil surface adjacent to the tree. Field soil assessment showed strong redoximorphic color patterns in the adjacent soil. We think that there is a transport link between the soil and stem via the root system representing a preferential transport mechanism for CH4 despite the fact that beech roots usually do not bear aerenchyma. The gas transport process , either via dissolved CH4 in the xylem water or in the root gas phase, is not yet clear. The observed CH4 stem emissions represent an important CH4flux in this ecosystem, und thus should be considered in future research. AcknowledgementThis research was financially supported by the Czech Academy of Sciences and the German Academic Exchange Service within the project "Methane (CH4) and nitrous oxide (N2O) emissions from Fagus sylvatica trees" (DAAD-15-03), National Programme for Sustainability I (LO1415) and project DFG (MA 5826/2-1). We would like to thank Marek Jakubik, Katerina Svobodova, Sinikka Paulus, Ellen Halaburt and Sally Haddad for technical support.

  16. Construction of somatic and motor skills of people training taekwondo WTF

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    Cieslicka Miroslawa.

    2012-10-01

    Full Text Available The purpose of this study was to analyze in terms of somatic and motor skills young people from high school in Bydgoszcz, taekwondo class profile. The object of the study were participants of Interschool Student Sports Club "Piętnastka" training this sport. The study included 36 patients aged 14.5, 15.5 and 16.5 years. Measured the height and body weight were and done the International Physical Fitness Test which included the following tests: long jump, hang on bent arms (girls or rising in the overhang on the stick (boys, shuttles run 4 x 10 m moving pads, traces of the lying and the slope in front trunk. The results were analyzed by gender and age, and tested the correlation between pairs of traits. It also examined how young people from their own studies compare to peers in the regional study conducted in 2005 by Marek Napierala [3]. After analyzing the test results the following conclusions: 1 Boys from our studies are characterized by a greater height and weight and achieve better results in all samples IPFT than girls; 2 Physical fitness increases with age - the best results attained IPFT students from the oldest age group (16.5 years; 3 Good results in other trials provide good performance in the course of 4 x 10 m; 4 Boys who train taekwondo in IPFT perform better than their peers from Kujawsko-Pomorskie in all age groups; 5 The sum of the calculated points obtained according to the scale T for girls is higher for taekwondo. However in not all trials, the girls from our studies performed better.

  17. A retrospective PCR investigation of avian Orthoreovirus, chicken infectious anemia and fowl Aviadenovirus genomes contamination in commercial poultry vaccines in Brazil

    Directory of Open Access Journals (Sweden)

    P.R. Barrios

    2012-02-01

    Full Text Available Vacinas avícolas vivas comerciais produzidas entre 1991 e 2005 foram examinadas para a presença de genomas dos vírus da anemia infecciosa das galinhas (Gyrovirus CAV, da hepatite por corpúsculo de inclusão (Aviadenovirus FAdV e da artrite viral/síndrome da má absorção (Orthoreovirus aviário ARV. Vinte e seis partidas de vacinas vivas liofilizadas de oito fabricantes com lacre original foram examinadas. As extrações de DNA e PCR de CAV e FAdV, e de RNA e RT-PCR para ARV, foram descritas previamente. Contaminações triplas de ARV, CAV e FAdV foram detectadas em vacinas de mesmo fabricante, produzidas em 1991 e 1992 contra a doença de Newcastle (DN, e para a encefalomielite aviária, produzida em 1994. ARV e CAV em co-infecção foram encontrados em vacinas contra a doença de Marek liofilizadas produzidas em 1996 por dois fabricantes diferentes. Genoma de ARV foi detectado em vacinas contra a bronquite infecciosa de setembro e dezembro de 1998, doença infecciosa bursal, de dezembro de 1998 e DN de janeiro de 1998. Três dos oito fabricantes apresentaram vacinas com contaminação e cinco nunca apresentaram vacinas contaminadas. Nenhuma vacina produzida a partir de 2001 apresentou contaminação. Cogita-se um papel epidemiológico para vacinas vivas, como fonte de infecção para ARV, CAV e FAdV e, potencialmente determinante da atual alta disseminação destes.

  18. Nonlinear Dynamics, Chaotic and Complex Systems

    Science.gov (United States)

    Infeld, E.; Zelazny, R.; Galkowski, A.

    2011-04-01

    Part I. Dynamic Systems Bifurcation Theory and Chaos: 1. Chaos in random dynamical systems V. M. Gunldach; 2. Controlling chaos using embedded unstable periodic orbits: the problem of optimal periodic orbits B. R. Hunt and E. Ott; 3. Chaotic tracer dynamics in open hydrodynamical flows G. Karolyi, A. Pentek, T. Tel and Z. Toroczkai; 4. Homoclinic chaos L. P. Shilnikov; Part II. Spatially Extended Systems: 5. Hydrodynamics of relativistic probability flows I. Bialynicki-Birula; 6. Waves in ionic reaction-diffusion-migration systems P. Hasal, V. Nevoral, I. Schreiber, H. Sevcikova, D. Snita, and M. Marek; 7. Anomalous scaling in turbulence: a field theoretical approach V. Lvov and I. Procaccia; 8. Abelian sandpile cellular automata M. Markosova; 9. Transport in an incompletely chaotic magnetic field F. Spineanu; Part III. Dynamical Chaos Quantum Physics and Foundations Of Statistical Mechanics: 10. Non-equilibrium statistical mechanics and ergodic theory L. A. Bunimovich; 11. Pseudochaos in statistical physics B. Chirikov; 12. Foundations of non-equilibrium statistical mechanics J. P. Dougherty; 13. Thermomechanical particle simulations W. G. Hoover, H. A. Posch, C. H. Dellago, O. Kum, C. G. Hoover, A. J. De Groot and B. L. Holian; 14. Quantum dynamics on a Markov background and irreversibility B. Pavlov; 15. Time chaos and the laws of nature I. Prigogine and D. J. Driebe; 16. Evolutionary Q and cognitive systems: dynamic entropies and predictability of evolutionary processes W. Ebeling; 17. Spatiotemporal chaos information processing in neural networks H. Szu; 18. Phase transitions and learning in neural networks C. Van den Broeck; 19. Synthesis of chaos A. Vanecek and S. Celikovsky; 20. Computational complexity of continuous problems H. Wozniakowski; Part IV. Complex Systems As An Interface Between Natural Sciences and Environmental Social and Economic Sciences: 21. Stochastic differential geometry in finance studies V. G. Makhankov; Part V. Conference Banquet

  19. Parcelling activity of the National Bank for Agriculture in interwar Poland in the years 1924-1929

    Directory of Open Access Journals (Sweden)

    Mirosław Kłusek

    2009-01-01

    Full Text Available Scientific literature related to the problem in focus is exceptionally poor. The only book publication concerns the National Bank for Agriculture in the twenty-year interwar period is book position of Marek Nowak’s authorship [Nowak 1988]. But, on account of its modest range, bank agrarian activity has been treated too generally. In this publication author’s opinion is that this activity needs deeper analysis. Parcelling is an economic process which took part in Poland and lasted from the moment of grant freehold. It ran with special intensification towards the end of XIX century and at the beginning of XX century. In inter-war period, on account of source of parcelled soil, parcellation was divided into private and governmental. Governmental parcellation, which related to public property, included lands by Regional District Councils and territories included by military settlement. However, lands allocated by the National Bank for Agriculture and by individual people made private parcellation. The beginning of the National Bank for Agriculture’s agrarian activity’ was enabled by Poland President’s directive from 1924. One of the main tasks put against NBA was support: parcellation and settlement, agricul-tural regulations by landed estates purchase for parcelling aims and giving long-term credits for land purchase. However, according to status, the National Bank for Agriculture was able to parcel out landed properties, both purchased for private property and entrusted to commission state. Tasks put against parcellation conducted by the National Bank for Ag-riculture were not carried out in a satisfactory way. The Bank’s activity did not contribute to shopping the process of farms fragmentation at serious level and process of agrarian overpopulation’s growth among fewer ownership. Similarly, it also was not an essential source of establishing new farms capable of competing with vast-land ownership.

  20. Expression patterns of endogenous avian retrovirus ALVE1 and its response to infection with exogenous avian tumour viruses.

    Science.gov (United States)

    Hu, Xuming; Zhu, Wenqi; Chen, Shihao; Liu, Yangyang; Sun, Zhen; Geng, Tuoyu; Song, Chengyi; Gao, Bo; Wang, Xiaoyan; Qin, Aijian; Cui, Hengmi

    2017-01-01

    Endogenous retroviruses (ERVs) are genomic elements that are present in a wide range of vertebrates and have been implicated in a variety of human diseases, including cancer. However, the characteristic expression patterns of ERVs, particularly in virus-induced tumours, is not fully clear. DNA methylation was analysed by bisulfite pyrosequencing, and gene expression was analysed by RT-qPCR. In this study, we first found that the endogenous avian retrovirus ALVE1 was highly expressed in some chicken tissues (including the heart, bursa, thymus, and spleen) at 2 days of age, but its expression was markedly decreased at 35 days of age. In contrast, the CpG methylation level of ALVE1 was significantly lower in heart and bursa at 2 days than at 35 days of age. Moreover, we found that the expression of ALVE1 was significantly inhibited in chicken embryo fibroblast cells (CEFs) and MSB1 cells infected with avian leukosis virus subgroup J (ALVJ) and reticuloendotheliosis virus (REV) at the early stages of infection. In contrast, the expression of the ALVE1 env gene was significantly induced in CEFs and MSB1 cells infected with Marek's disease virus (MDV). However, the methylation and expression levels of the ALVE1 long terminal repeat (LTR) did not show obvious alterations in response to viral infection. The present study revealed the expression patterns of ALVE1 in a variety of chicken organs and tissues and in chicken cells in response to avian tumour virus infection. These findings may be of significance for understanding the role and function of ERVs that are present in the host genome.

  1. The influence of methods of bariatric surgery for treatment of type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Bužga M

    2016-04-01

    Full Text Available Marek Bužga,1 Petra Maresova,2 Adela Seidlerová,1 Pavel Zonča,1 Pavol Holéczy,1 Kamil Kuča2,3 1Research Obesity Center, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic; 2Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic; 3Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic Abstract: The constantly growing incidence of obesity represents a risk of health complications for individuals, and is a growing economic burden for health care systems and society. The aim of this study was to evaluate the efficacy of bariatric surgery, specifically laparoscopic greater curve plication, laparoscopic sleeve gastrectomy, and Roux-en-Y gastric bypass, in patients with type 2 diabetes mellitus. The effect of bariatric surgery on the changes in blood pressure before, and 12 months after, surgery and in pharmacotherapy in the 12 months after surgery was analyzed. For achieving this purpose, 74 patients from the Obesity and Surgery Department of Vitkovice Hospital in Ostrava in the Czech Republic, were monitored. They were operated in 2011 and 2012. The Bonferroni method was used to test hypotheses about the impact of surgery on blood pressure and pharmacotherapy. One year after the surgery, systolic and diastolic blood pressure values decreased, both with no statistically significant difference between surgery types. Improvement was observed in 68% of cases, with 25% of patients discontinuing pharmacotherapy entirely. Keywords: type 2 diabetes mellitus, bariatric surgery, blood pressure, pharmacotherapy

  2. INFLUENCIA DE UNA VACUNA VECTORIZADA (MAREKGUMBORO EN POLLOS DE LA LÍNEA GENÉTICA COBB 500

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    Fátima Graciela Arteaga Chávez

    2013-12-01

    Full Text Available El presente trabajo tuvo como objetivo evaluar el efecto de una vacuna vectorizada (Marek - Gumboro en pollos COBB 500. Se utilizaron 1300 pollitos con pesos promedio al nacer de 43 g los cuales se dividieron en dos grupos, el primero con 625 pollitos BB se aplicó la vacuna vectorizada y el segundo, con 675 pollitos BB, se aplicó la vacuna tradicional. Como indicado- res productivos se midió peso vivo semanal, peso a la canal y conversión alimenticia; para los indicadores de salud e inocuidad de la vacuna se consideró morbilidad y mortalidad; los indi- cadores inmunológicos fueron el peso y tamaño de bolsa de Fabricio, bazo y timo. Además, se registró los ingresos y egresos de la producción. Se observó que los parámetros productivos tan- to peso vivo, conversión alimenticia, mortalidad, peso a la canal, estuvieron influenciados por la aplicación de la vacuna vectorizada (p<0.001 entre las semanas cuarta y sexta de edad. En la vacuna tradicional se tuvo un mayor grado de mortalidad con 1.62%. Los órganos linfoides tuvieron diferencias significativa (p<0.05 siendo de mayor tamaño en el grupo que recibió la vacuna vectorizada. Para el parámetro costo beneficio se observó una utilidad de 0.05 centavos por cada dólar invertido. El uso de la vacuna vectorizada en la producción de pollos de ceba COBB 500 favorece, tanto los parámetros productivos, como económicos.

  3. Therapy of psoriasis with narrowband ultraviolet-B light influences plasma concentrations of MMP-2 and TIMP-2 in patients

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    Głażewska EK

    2016-10-01

    Full Text Available Edyta Katarzyna Głażewska,1 Marek Niczyporuk,1 Sławomir Ławicki,2 Maciej Szmitkowski,2 Monika Zajkowska,2 Grażyna Ewa Będkowska,3 Andrzej Przylipiak1 1Department of Esthetic Medicine, 2Department of Biochemical Diagnostics, 3Department of Haematological Diagnostics, Medical University, Białystok, Poland Background: Matrix metalloproteinases (MMPs, which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs, which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before and after the course of narrowband ultraviolet-B (NBUVB therapy with respect to disease advancement. Patients and methods: A total of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were enrolled into the study. Plasma levels of MMP-2 and TIMP-2 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index (PASI was used to define the disease advancement. Results: The results showed increased plasma levels of MMP-2 and TIMP-2, but this change was significant only in case of MMP-2 in total psoriatic group compared to healthy subjects. Moreover, there was an increase in the concentrations of chosen factors with an increase in the severity of the disease. The NBUVB therapy causes a decline in the concentration of the analyzed enzyme and its inhibitor, although this change was statistically significant in the total psoriatic group only in case of MMP-2. There was also a positive correlation between MMP-2, TIMP-2, and PASI score value. Conclusion: Our study highlights a possible important role of MMP-2 in the activity of psoriasis and clearance of disease symptoms. Moreover, plasma MMP-2 seems to be a valuable psoriasis biomarker. Keywords: gelatinase A, matrix metalloproteinases, tissue inhibitor of

  4. Innovation and discovery: the application of nucleic acid-based technology to avian virus detection and characterization.

    Science.gov (United States)

    Cavanagh, D

    2001-12-01

    Polymerase chain reaction (PCR)-based approaches to the detection, differentiation and characterization of avian pathogens continue to be developed and refined. The PCRs, or reverse transcriptase-PCRs, may be general, designed to detect all or most variants of a pathogen, or to be serotype, genotype or pathotype specific. Progress is being made with respect to making nucleic acid approaches more suitable for use in diagnostic laboratories. Robotic workstations are now available for extraction of nucleic acid from many samples in a short time, for routine diagnosis. Following general PCR, the DNA products are commonly analyzed by restriction endonuclease mapping (restriction fragment length polymorphism), using a small number of restriction endonucleases, based on a large body of sequence data. Increasingly, however, nucleotide sequencing is being used to analyze the DNA product, in part due to the expanding use of non-radioactive sequencing methods that are safe and enable high throughout. In this review, I highlight some recent developments with many avian viruses: Newcastle disease virus; circoviruses in canary and pigeon; infectious bursal disease virus (Gumboro disease virus); avian adenoviruses, including Angara disease/infectious hydropericardium virus, haemorrhagic enteritis virus of turkeys, and egg drop syndrome virus; avian herpesviruses, including infectious laryngotracheitis virus, duck plague virus, psittacine herpesvirus (Pacheco's parrot disease virus), Marek's disease virus and herpesvirus of turkeys; avian leukosis virus (associated with lymphoid leukosis or myeloid leukosis, and egg transmission); avian pneumoviruses (turkey rhinotracheitis virus); avian coronaviruses, including infectious bronchitis virus, turkey coronavirus and pheasant coronavirus; astrovirus, in the context of poult enteritis and mortality syndrome, and avian nephritis virus; and avian encephalomyelitis virus, a picornavirus related to hepatitis A virus.

  5. Herpesvirus of turkey recombinant viruses expressing infectious bursal disease virus (IBDV) VP2 immunogen induce protection against an IBDV virulent challenge in chickens.

    Science.gov (United States)

    Darteil, R; Bublot, M; Laplace, E; Bouquet, J F; Audonnet, J C; Rivière, M

    1995-08-20

    Two recombinant herpesviruses of turkey (HVT) expressing the VP2 protein of infectious bursal disease virus (IBDV or Gumboro disease virus) have been constructed: vHVT001 and vHVT002. The VP2 open reading frame was inserted at the locus of the small subunit of ribonucleotide reductase gene (HSV-1 UL40 homolog) without any exogenous promoter in vHVT001 and at the locus of gl gene (HSV-1 US7 homolog) under the control of the human cytomegalovirus immediate-early promoter in vHVT002. The isolation of these recombinant viruses indicated that the deleted genes were not required for replication of HVT in chicken embryo fibroblasts. Efficacy of these recombinant viruses against IBDV strain 52/70 and Marek's disease virus (MDV strain RB1B) virulent challenges was evaluated in chickens vaccinated at 1 day of age. In the IBDV challenge, a good protection against mortality and bursal gross lesion was observed in vHVT002-vaccinated chickens: 100% with 10(5) PFU dose and 60% with 10(4) PFU dose; in contrast, only a weak level of protection was achieved after vaccination with vHVT001. Protection levels against MDV challenge obtained with vHVT001 and vHVT002 were low (around 10%) compared to that induced by the parental HVT (84%). In spite of the low protection level against MDV, this is the first report which describes induction of full protection against IBDV with a single inoculation of a recombinant virus.

  6. The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV).

    Science.gov (United States)

    Butter, Colin; Staines, Karen; van Hateren, Andrew; Davison, T Fred; Kaufman, Jim

    2013-08-01

    In contrast to typical mammals, the chicken MHC (the BF-BL region of the B locus) has strong genetic associations with resistance and susceptibility to infectious pathogens as well as responses to vaccines. We have shown that the chicken MHC encodes a single dominantly expressed class I molecule whose peptide-binding motifs can determine resistance to viral pathogens, such as Rous sarcoma virus and Marek's disease virus. In this report, we examine the response to a molecular defined vaccine, fp-IBD1, which consists of a fowlpox virus vector carrying the VP2 gene of infectious bursal disease virus (IBDV) fused with β-galactosidase. We vaccinated parental lines and two backcross families with fp-IBD1, challenged with the virulent IBDV strain F52/70, and measured damage to the bursa. We found that the MHC haplotype B15 from line 15I confers no protection, whereas B2 from line 61 and B12 from line C determine protection, although another locus from line 61 was also important. Using our peptide motifs, we found that many more peptides from VP2 were predicted to bind to the dominantly expressed class I molecule BF2*1201 than BF2*1501. Moreover, most of the peptides predicted to bind BF2*1201 did in fact bind, while none bound BF2*1501. Using peptide vaccination, we identified one B12 peptide that conferred protection to challenge, as assessed by bursal damage and viremia. Thus, we show the strong genetic association of the chicken MHC to a T cell vaccine can be explained by peptide presentation by the single dominantly expressed class I molecule.

  7. Genome-wide mapping of DNase I hypersensitive sites and association analysis with gene expression in MSB1 cells

    Directory of Open Access Journals (Sweden)

    Yanghua eHe

    2014-10-01

    Full Text Available DNase I hypersensitive sites (DHSs mark diverse classes of cis-regulatory regions, such as promoters and enhancers. MSB-1 derived from chicken Marek's disease (MD lymphomas is an MDV-transformed CD4+ T-cell line for MD study. Previously, DNase I HS sites were studied mainly in human cell types for mammalian. To capture the regulatory elements specific to MSB1 cells and explore the molecular mechanisms of T-cell transformation caused by MDV in MD, we generated high-quality of DHSs map and gene expression profile for functional analysis in MSB1 cell line. The total of 21,724 significant peaks of DHSs was identified from around 40 million short reads. DHSs distribution varied between chromosomes and they preferred to enrich in the gene-rich chromosomes. More interesting, DHSs enrichments appeared to be scarce on regions abundant in CpG islands. Besides, we integrated DHSs into the gene expression data and found that DHSs tended to enrich on high expressed genes throughout whole gene regions while DHSs did not show significant changes for low and silent expressed genes. Furthermore, the correlation of DHSs with lincRNAs expression was also calculated and it implied that enhancer-associated lincRNAs probably originated from enhancer-like regions of DHSs. Together, our results indicated that DNase I HS sites highly correlate with active genes expression in MSB1 cells, suggesting DHSs can be considered as markers to identify the cis-regulatory elements associated with chicken Marek’s disease.

  8. Health evaluation of free-ranging and captive blue-fronted Amazon parrots (Amazona aestiva) in the Gran chaco, Bolivia.

    Science.gov (United States)

    Deem, Sharon L; Noss, Andrew J; Cuéllar, Rosa Leny; Karesh, William B

    2005-12-01

    Bolivia has a total of 47 species of Psittacidae, seven of which have been identified in our study site, the semiarid Gran Chaco of the Isoso. One species, the blue-fronted parrot (Amazona aestiva), is frequently captured by local Isoseño Guaraní Indians for exploitation on the national and international market. These birds are often temporarily housed in small villages under unhygienic conditions with poultry and other domestic species. On occasion, these parrots escape back to the wild. Additionally, many of these birds are kept as pets or are used to lure wild. parrots within slingshot range for subsequent capture. In this study, we evaluated the health status, including the level of exposure to selected infectious agents, in the wild-caught captive birds and free-ranging birds. Physical examinations were performed, and blood was collected, from 54 live birds (20 captive and 34 free-ranging). Feces were collected from 15 birds (seven captive and eight free-ranging). Necropsies were also performed on four recently dead wild-caught birds. On serologic testing, no birds were found to have antibodies to avian influenza virus, Chlamydophila psittaci, infectious bronchitis virus, infectious bursal disease virus, infectious laryngotracheitis virus, Marek's disease virus, paramyxovirus-1, paramyxovirus-2, paramyxovirus-3, polyomavirus, eastern equine encephalitis virus, western equine encephalitis virus, or Venezuelan equine encephalitis virus. Positive antibody titers were found for psittacine herpesvirus (8/44, 18.2%), Aspergillus spp. (3/51, 5.9%), and Salmonella pullorum (33/49, 67.3%). All three of the birds that tested antibody positive for Aspergillus spp. were captive, whereas six of the eight and 15 of the 33 birds that tested positive for psittacine herpesvirus and S. pullorum, respectively, were wild.

  9. The use of quartz crystal microbalance with dissipation (QCM-D for studying nanoparticle-induced platelet aggregation

    Directory of Open Access Journals (Sweden)

    Santos-Martinez MJ

    2012-01-01

    Full Text Available Maria Jose Santos-Martinez1–3, Iwona Inkielewicz-Stepniak1,4, Carlos Medina1, Kamil Rahme5,6, Deirdre M D'Arcy1, Daniel Fox3, Justin D Holmes3,5, Hongzhou Zhang3, Marek Witold Radomski3,51School of Pharmacy and Pharmaceutical Sciences, 2School of Medicine, 3Center for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Dublin, Ireland; 4Department of Medicinal Chemistry, Medical University of Gdansk, Gdansk, Poland; 5Materials and Supercritical Fluids Group, Department of Chemistry and the Tyndall National Institute, University College Cork, Cork, Ireland; 6Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University, Zouk Mosbeh, LebanonAbstract: Interactions between blood platelets and nanoparticles have both pharmacological and toxicological significance and may lead to platelet activation and aggregation. Platelet aggregation is usually studied using light aggregometer that neither mimics the conditions found in human microvasculature nor detects microaggregates. A new method for the measurement of platelet microaggregation under flow conditions using a commercially available quartz crystal microbalance with dissipation (QCM-D has recently been developed. The aim of the current study was to investigate if QCM-D could be used for the measurement of nanoparticle-platelet interactions. Silica, polystyrene, and gold nanoparticles were tested. The interactions were also studied using light aggregometry and flow cytometry, which measured surface abundance of platelet receptors. Platelet activation was imaged using phase contrast and scanning helium ion microscopy. QCM-D was able to measure nanoparticle-induced platelet microaggregation for all nanoparticles tested at concentrations that were undetectable by light aggregometry and flow cytometry. Microaggregates were measured by changes in frequency and dissipation, and the presence of platelets on the sensor surface was confirmed and imaged by

  10. Pseudo-chaotic oscillations in CRISPR-virus coevolution predicted by bifurcation analysis.

    Science.gov (United States)

    Berezovskaya, Faina S; Wolf, Yuri I; Koonin, Eugene V; Karev, Georgy P

    2014-07-02

    Sandor Pongor, Sergei Maslov and Marek Kimmel. For the complete reports, go to the Reviewers' Reports section.

  11. Inverse modeling of GOSAT-retrieved ratios of total column CH4 and CO2 for 2009 and 2010

    Directory of Open Access Journals (Sweden)

    S. Pandey

    2016-04-01

    over Australia and in the tropics. The ratio method stays closer to the a priori CH4 flux in these regions, because it is capable of simultaneously adjusting the CO2 fluxes. Over tropical South America, comparison to independent measurements shows that CO2 fields derived from the ratio method are less realistic than those used in the proxy method. However, the CH4 fluxes are more realistic, because the impact of unaccounted systematic uncertainties is more evenly distributed between CO2 and CH4. The ratio inversion estimates an enhanced CO2 release from tropical South America during the dry season of 2010, which is in accordance with the findings of Gatti et al. (2014 and Van der Laan et al. (2015. The performance of the ratio method is encouraging, because despite the added nonlinearity due to the assimilation of Xratio and the significant increase in the degree of freedom by optimizing CO2 fluxes, still consistent results are obtained with respect to other CH4 inversions.

  12. Inverse modeling of GOSAT-retrieved ratios of total column CH4 and CO2 for 2009 and 2010

    Science.gov (United States)

    Pandey, Sudhanshu; Houweling, Sander; Krol, Maarten; Aben, Ilse; Chevallier, Frédéric; Dlugokencky, Edward J.; Gatti, Luciana V.; Gloor, Emanuel; Miller, John B.; Detmers, Rob; Machida, Toshinobu; Röckmann, Thomas

    2016-04-01

    ratio method stays closer to the a priori CH4 flux in these regions, because it is capable of simultaneously adjusting the CO2 fluxes. Over tropical South America, comparison to independent measurements shows that CO2 fields derived from the ratio method are less realistic than those used in the proxy method. However, the CH4 fluxes are more realistic, because the impact of unaccounted systematic uncertainties is more evenly distributed between CO2 and CH4. The ratio inversion estimates an enhanced CO2 release from tropical South America during the dry season of 2010, which is in accordance with the findings of Gatti et al. (2014) and Van der Laan et al. (2015). The performance of the ratio method is encouraging, because despite the added nonlinearity due to the assimilation of Xratio and the significant increase in the degree of freedom by optimizing CO2 fluxes, still consistent results are obtained with respect to other CH4 inversions.

  13. EDITORIAL: The Fifth International Workshop and Summer School on Plasma Physics

    Science.gov (United States)

    2006-04-01

    , Russia, the US, China, South Korea and India (as of March 2006). It will take several years to accomplish this important task. There is no doubt that the success depends not only on funding but also on enthusiastic people willing to contribute with their skills and knowledge. Young scientists and engineers must be enrolled to the programme and trained in various disciplines of fusion science and technology. There are various education schemes and work programmes. Organization of summer schools on fusion-related plasma physics is an important part of the training process. Several schools are organized annually or every second year in Europe. Fusion-related science is so vast that it is impossible to cover all topics during an event lasting for one or two weeks. Therefore, each school has its distinctive features and focuses on a selected group of issues to be addressed in depth. This also applies to the Workshop and Summer School on Plasma Physics in Kudowa Zdrój (Poland) that, has been organised annually since 2001. It was initiated by Dr Marek Scholz with the help of his colleagues from the Institute of Plasma Physics and Laser Microfusion (IPPLM) in Warsaw. The idea was to create a forum for students mainly from Eastern Europe to learn and discuss subjects in general plasma physics and dense magnetized media, predominantly in plasma focus devices. Over the years the school has matured and created a clear profile. A unique feature has always been to accommodate in the programme not only tutorials delivered by invited senior scientists but also presentations prepared by the students. In June 2005 the 5th Workshop and Summer School on Plasma Physics was held under the heading 'Towards Fusion Energy: Plasma Physics, Diagnostics, Applications'. There were 59 participants, including 44 students, coming from plasma physics and material research laboratories in 17 countries: Belgium, Czech Republic, France, Germany, Georgia, Iran, Italy, Lithuania, Poland, Romania, Russia

  14. Pharmacokinetics, safety, and efficacy of APF530 (extended-release granisetron in patients receiving moderately or highly emetogenic chemotherapy: results of two Phase II trials

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    Gabrail N

    2015-03-01

    Full Text Available Nashat Gabrail,1 Ronald Yanagihara,2 Marek Spaczyński,3 William Cooper,4 Erin O'Boyle,5 Carrie Smith,1 Ralph Boccia6 1Gabrail Cancer Center, Canton, OH, USA; 2St Louise Regional Hospital, Gilroy, CA, USA; 3Department of Gynecology, Obstetrics and Gynecologic Oncology, University of Medical Sciences, Poznan, Poland; 4TFS International, Flemington, NJ, USA; 5FibroGen, Inc., San Francisco, CA, USA; 6Center for Cancer and Blood Disorders, Bethesda, MD, USA Background: Despite advances with new therapies, a significant proportion of patients (>30% suffer delayed-onset chemotherapy-induced nausea and vomiting (CINV despite use of antiemetics. APF530 is a sustained-release subcutaneous (SC formulation of granisetron for preventing CINV. APF530 pharmacokinetics, safety, and efficacy were studied in two open-label, single-dose Phase II trials (C2005-01 and C2007-01, respectively in patients receiving moderately emetogenic chemotherapy or highly emetogenic chemotherapy. Methods: In C2005-01, 45 patients received APF530 250, 500, or 750 mg SC (granisetron 5, 10, or 15 mg, respectively. In C2007-01, 35 patients were randomized to APF530 250 or 500 mg SC. Injections were given 30 to 60 minutes before single-day moderately emetogenic chemotherapy or highly emetogenic chemotherapy. Plasma granisetron was measured from predose to 168 hours after study drug administration. Safety and efficacy were also evaluated. Results: APF530 pharmacokinetics were dose proportional, with slow absorption and elimination of granisetron after a single SC dose. Median time to maximum plasma concentration and half-life were similar for APF530 250 and 500 mg in both trials, with no differences between the groups receiving moderately and highly emetogenic chemotherapy. Exposure to granisetron was maintained at a therapeutic level over the delayed-onset phase, at least 168 hours. Adverse events in both trials were as expected for granisetron; injection site reactions (eg, erythema

  15. MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines

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    Smith Lorraine P

    2010-05-01

    Full Text Available Abstract Background Micro(miRNAs are a class of small non-coding RNAs that play critical roles in the induction of various cancers, including lymphomas induced by oncogenic viruses. While some of the miRNAs are oncogenic, miRNAs such as miR-26a are consistently downregulated in a number of cancers, demonstrating their potential tumor suppressor functions. Global miRNA expression profiles of a number of virus-transformed avian lymphoma cell lines have shown downregulation of gga-miR-26a expression, irrespective of molecular mechanisms of transformation or the viral aetiology. The neoplastic transformation of lymphocytes by many viruses accompanies high levels of proliferative responses, mostly mediated through cytokines such as IL-2. Chicken IL-2 can modulate T-cell proliferation and cytotoxicity in vitro and in vivo and dysregulation of IL-2 expression is observed in diseases such as leukaemia. Results The expression levels of gga-miR-26a in chicken lymphoma cells transformed by 3 distinct avian oncogenic viruses, viz Marek's disease virus (MDV, avian leukosis virus (ALV and Reticuloendotheliosis virus (REV were consistently downregulated compared to the levels in the normal lymphocytes. This downregulation of miR-26a regardless of the viral etiology and molecular mechanisms of transformation was consistent with the tumor suppressor role of this miRNA. Notwithstanding this well-established role in cancer, we demonstrate the additional role of this miRNA in directly targeting chicken IL-2 through reporter and biochemical assays. The downregulation of miR-26a can relieve the suppressive effect of this miRNA on IL-2 expression. Conclusions We show that miR-26a is globally downregulated in a number of avian lymphoma cells irrespective of the mechanisms of transformation, reiterating the highly conserved tumor suppressor function of this miRNA. However, with the potential for directly targeting chicken IL-2, the downregulation of miR-26a in these

  16. Comparative virology and AIDS (review).

    Science.gov (United States)

    Kodama, M; Kodama, T

    1996-03-01

    The scientific debate between pros and cons of the HIV criminal theory of AIDS still remains unsettled. The purpose of this review is to promote resolution of the problem by extracting a common principle of the host-virus relation using data resources for each of 4 viruses as follows: a) polyoma virus, b) Marek's disease virus, c) Ebola virus, d) Korean hemorrhagic fever virus. Conclusions drawn from this study are given as follows: i) Environment emerged as the cardinal factor to modify the process of virus infection in all of the 4 viruses studied. Above all, an accelerating effect of environmental stress on the progression of virus infection was noted in vivo in the majority of viral diseases. ii) Evidence is available to indicate that a healthy cell (or a healthy individual) may harbor virus genes of multiple species without manifesting any pathologic sign. iii) Evidence also suggests that the biological property as well as morphological structure of a virus may vary in reponse to a change of the bioenvironment. On the basis of the above information, we propose to renounce 2 assumptions of classical infection model: a) the hereditarily determined virulence of a microorganism (including virus) be the sole determinant of infection to the effect that its invasion into the host should automatically complete the programmed course of infection; b) virus, a quasi-living creature, should reserve its behavioral independence irrespective of a change of the bioenvironment. The new infection model was constructed on the basis of the selfish gene concept that had been invented by Richard Dawkins to explain the altruistic behavior of an individual. That is, the fate of an exogenous or endogenous virus is under the dual control of the host genome (selfish gene) and the outer environment. The progression of virus infection is conditioned by a crosstalk between them. The selfish gene may use virus (a lifeless substance) as a magic bullet to induce a designated host response. In

  17. CH_{4} production in the deep soil as a source of stem CH_{4} emission in Fagus sylvatica}

    Science.gov (United States)

    Maier, Martin; Machacova, Katerina; Urban, Otmar; Lang, Friederike

    2017-04-01

    /2-1). We would like to thank Marek Jakubik, Sinikka Paulus, Ellen Halaburt and Sally Haddad for technical support.

  18. Raw Pea (Pisum sativum, raw Faba bean (Vicia faba var. minor and raw Lupin (Lupinus albus var. multitalia as alternative protein sources in broiler diets

    Directory of Open Access Journals (Sweden)

    Gianfranco Piva

    2010-01-01

    Full Text Available The ban of the meat and bone meal for entering animal diets and the concern of transgenic feeds poses a challenge toanimal nutritionists in Europe. The challenge is to find homegrown protein-rich feedstuffs, making sure no antinutritionalfactors are present which could interfere in the animals’ performance. The raw Pea (Pisum sativum (RP, raw Fababean (Vicia faba, variety minor (RFb and raw Lupin (Lupinus albus, variety multitalia (RL were evaluated as alternativeprotein sources into broiler diets. Six hundred thirty 1d-old Ross male chicks, Marek vaccinated, were randomlyassigned to seven dietary treatments (5 pens per treatment/18 birds per pen. Chicks were floor housed, ad libitum fedisocaloric and isonitrogenous diets and had free access to water. Artificial light was provided 10 h/d. The bulk of the basediet (control diet was corn (48.7%, 56.6% and 57%, solvent-extracted soybean meal (42.8%, 37.3% and 33.4%, cornoil (4.4%, 5.2% and 6.3%, plus synthetic amino acids, minerals, trace minerals and vitamins, respectively for the 1-10d-old, 11-28d-old and 29 to 42d-old growing periods. The RP, RFb and RL entered diets in substitution of the soybeanand corn according to the cost optimization (P100, Fb100 and L100, respectively for RP, RFb and RL and at half of theoptimized quantity (RP50, RFb50 and RL50, respectively for RP, RFb and RL. The amount used as fed basis for the higherlevel of inclusion were: P100: 350 g/kg for all diets; Fb100: 480 g/kg (1-10d-old and 500 g/kg (11-42d-old; L100:360 g/kg (1-10d-old and 300 g/kg (11-42d-old. The average daily gain (ADG were lower (P compared to the control group. Over the whole period of growth, the RFb group had similar ADG compared to the controlgroup and for both levels of inclusion, whereas reduced (P (P growth. Birds performance was improved (P and breast and leg quarter cuts. The RFb and RL could represent valuable protein feeds in broilers diet formulation.

  19. Small RNA cloning and sequencing strategy affects host and viral microRNA expression signatures.

    Science.gov (United States)

    Stik, Grégoire; Muylkens, Benoît; Coupeau, Damien; Laurent, Sylvie; Dambrine, Ginette; Messmer, Mélanie; Chane-Woon-Ming, Béatrice; Pfeffer, Sébastien; Rasschaert, Denis

    2014-07-10

    The establishment of the microRNA (miRNA) expression signatures is the basic element to investigate the role played by these regulatory molecules in the biology of an organism. Marek's disease virus 1 (MDV-1) is an avian herpesvirus that naturally infects chicken and induces T cells lymphomas. During latency, MDV-1, like other herpesviruses, expresses a limited subset of transcripts. These include three miRNA clusters. Several studies identified the expression of virus and host encoded miRNAs from MDV-1 infected cell cultures and chickens. But a high discrepancy was observed when miRNA cloning frequencies obtained from different cloning and sequencing protocols were compared. Thus, we analyzed the effect of small RNA library preparation and sequencing on the miRNA frequencies obtained from the same RNA samples collected during MDV-1 infection of chicken at different steps of the oncoviral pathogenesis. Qualitative and quantitative variations were found in the data, depending on the strategy used. One of the mature miRNA derived from the latency-associated-transcript (LAT), mdv1-miR-M7-5p, showed the highest variation. Its cloning frequency was 50% of the viral miRNA counts when a small scale sequencing approach was used. Its frequency was 100 times less abundant when determined through the deep sequencing approach. Northern blot analysis showed a better correlation with the miRNA frequencies found by the small scale sequencing approach. By analyzing the cellular miRNA repertoire, we also found a gap between the two sequencing approaches. Collectively, our study indicates that next-generation sequencing data considered alone are limited for assessing the absolute copy number of transcripts. Thus, the quantification of small RNA should be addressed by compiling data obtained by using different techniques such as microarrays, qRT-PCR and NB analysis in support of high throughput sequencing data. These observations should be considered when miRNA variations are studied

  20. An international, multicenter, observational survey to evaluate diabetes control in subjects using insulin for the treatment of type 1 and type 2 diabetes mellitus in the Czech Republic and Slovak Republic: study protocol for a cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Brož J

    2016-06-01

    Full Text Available Jan Brož,1 Denisa Janickova Zdarska,1 Jana Urbanova,2 Marek Brabec,3 Bohumila Krivska,4 Viera Donicova,5 Radka Stepanova,6 Emil Martinka,7 Milan Kvapil1 1Department of Internal Medicine, Second Faculty of Medicine, 2Center for Research on Diabetes, Metabolism and Nutrition, Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, 3Institute of Computer Science of the ASCR, vvi, 4Sanofi, Prague, Czech Republic; 5Private Department of Diabetology, Internal Medicine and Metabolism, Kosice, Slovak Republic; 6ADDS sro, Brno, Czech Republic; 7National Institute of Endocrinology and Diabetology, Lubochna, Slovak Republic Background: Despite the improvements in insulin therapy, a large number of patients fail to achieve their target glycated hemoglobin (HbA1c levels. Control of diabetes is often unsatisfactory because the patient does not know about the principles of successful insulin therapy (ie, blood glucose self-monitoring, the principles of insulin administration, titration, current dose adjustments, dietary recommendations, and physical activity preventive measures or because these principles are applied incorrectly or insufficiently. Furthermore, the fear of hypoglycemia may lead to maintaining higher than recommended blood glucose levels. Methods/design: This is a noninterventional, international study focusing on a questionnaire survey of diabetes patients (patient-reported outcome treated with insulin for at least 1 year. It is designed so that the data obtained reflect real access of patients to insulin treatment. The primary objective is to show the results of glycemic control of diabetes (HbA1c achieved in diabetes patients treated with at least one dose of insulin. The secondary objective is to monitor the factors potentially affecting these results, which include the frequency and other characteristics of hypoglycemia, the frequency of blood glucose self-monitoring, and the effects produced when the results

  1. PLASMA-2005: International Conference on Research and Applications of Plasmas combined with the 3. German-Polish Conference on Plasma Diagnostics for Fusion and Applications and the 5. French-Polish Seminar on Thermal Plasma in Space and Laboratory. Book of Abstracts

    International Nuclear Information System (INIS)

    Ksiazek, K.

    2005-01-01

    The International Conferences 'PLASMA' have been organized in Poland every two years since 1993. The German-Polish Conferences on Plasma Diagnostics were started in 2002, and the French-Polish Seminars on Thermal Plasmas were initiated in 1997. To reduce a number of topical conferences and to improve an exchange of information among different plasma research groups it was agreed to organize for the first time the triple conference at the Opole University, Poland, on September 6-9, 2005. The chairman of the International Scientific Committee (ISC) was Professor Marek J. Sadowski from IPJ in Swierk, and the co-chairmen were Professor Thomas Klinger of the IPP-Greifswald and Professor Michel Dudeck of the CNRS-Orleans. The chairman of LOC was Professor Jozef Musielok of the Opole University. This conference was designed for interested scientists, engineers and students from all the countries, but particularly for these from the Central and Eastern Europe (see http://draco.uni.opole.pl/plasma2005). The scientific programme of the conference embraced almost all directions of plasma research and technology, i.e.: 1. Elementary processes and general theory of plasma; 2. Plasmas in tokamaks, stellerators and related experiments; 3. plasmas in Z-pinch and PF discharges; 4. Plasmas produced by intense laser beams; 5. Plasmas of micro-wave and glow discharges; 6. Plasmas in spark- and arc-discharges; 7. Plasmas in space; 8. Diagnostics and experimental facilities; 9. Applications of quasi-stationary and pulsed plasmas. Participants of the conference were 127 plasma experts (including 23 invited speakers) from 13 different countries, as well as several honorary guests from local authorities and the most important plasma research centers in Poland. Most numerous groups came from Poland (58 persons), Germany (15 persons), France (14 persons), Czech Republic (11 persons), Russia (7 persons), and Ukraine (6 persons). The participants came also from Belarus, Hungary, Iran, Japan

  2. A theoretical quantitative model for evolution of cancer chemotherapy resistance

    Directory of Open Access Journals (Sweden)

    Gatenby Robert A

    2010-04-01

    simultaneous administration of chemotherapy and 2-deoxy-glucose does not optimize treatment outcome because when simultaneously administered these drugs are antagonists. The best results were obtained when 2-deoxy-glucose was followed by chemotherapy in two separate doses. Conclusions These results suggest that the maximum potential of a combined therapy may depend on how each of the drugs modifies the evolutionary landscape and that a rational use of these properties may prevent or at least delay relapse. Reviewers This article was reviewed by Dr Marek Kimmel and Dr Mark Little.

  3. Antimicrobial nanocapsules: from new solvent-free process to in vitro efficiency

    Directory of Open Access Journals (Sweden)

    Steelandt J

    2014-09-01

    Full Text Available Julie Steelandt,1 Damien Salmon,1,2 Elodie Gilbert,1 Eyad Almouazen,3 François NR Renaud,4 Laurène Roussel,1 Marek Haftek,5 Fabrice Pirot1,2 1University Claude Bernard Lyon 1, Faculty of Pharmacy, Fundamental, Clinical and Therapeutic Aspects of Skin Barrier Function, FRIPharm, Laboratoire de Pharmacie Galénique Industrielle, 2Hospital Pharmacy, FRIPharm, Hospital Edouard Herriot, Hospices Civils de Lyon, 3Laboratoire d’Automatique et de Génie des Procédés, University Claude Bernard Lyon 1, 4University Claude Bernard Lyon 1, UMR CNRS 5510/MATEIS, 5University Claude Bernard Lyon 1, Faculty of Pharmacy, Fundamental, Clinical and Therapeutic Aspects of Skin Barrier Function, FRIPharm, Laboratoire de Dermatologie, Lyon, France Abstract: Skin and mucosal infections constitute recurrent pathologies resulting from either inappropriate antiseptic procedures or a lack of efficacy of antimicrobial products. In this field, nanomaterials offer interesting antimicrobial properties (eg, long-lasting activity; intracellular and tissular penetration as compared to conventional products. The aim of this work was to produce, by a new solvent-free process, a stable and easily freeze-dryable chlorhexidine-loaded polymeric nanocapsule (CHX-NC suspension, and then to assess the antimicrobial properties of nanomaterials. The relevance of the process and the physicochemical properties of the CHX-NCs were examined by the assessment of encapsulation efficiency, stability of the nanomaterial suspension after 1 month of storage, and by analysis of granulometry and surface electric charge of nanocapsules. In vitro antimicrobial activities of the CHX-NCs and chlorhexidine digluconate solution were compared by measuring the inhibition diameters of two bacterial strains (Escherichia coli and Staphylococcus aureus and one fungal strain (Candida albicans cultured onto appropriate media. Based on the findings of this study, we report a new solvent-free process for the

  4. Some Metric Properties of Planar Gaussian Free Field

    Science.gov (United States)

    Goswami, Subhajit

    behavior by showing that the expected exit time from a ball of radius N scales as Npsi(gamma)+o(1) with psi(gamma) > 2 for all gamma > 0. The contents of these chapters are based on a joint work with Marek Biskup and Jian Ding.

  5. Effects of immunosuppressive treatment on protein expression in rat kidney

    Directory of Open Access Journals (Sweden)

    Kędzierska K

    2014-09-01

    Full Text Available Karolina Kędzierska,1 Katarzyna Sporniak-Tutak,2 Krzysztof Sindrewicz,2 Joanna Bober,3 Leszek Domański,1 Mirosław Parafiniuk,4 Elżbieta Urasińska,5 Andrzej Ciechanowicz,6 Maciej Domański,1 Tomasz Smektała,2 Marek Masiuk,5 Wiesław Skrzypczak,6 Małgorzata Ożgo,6 Joanna Kabat-Koperska,1 Kazimierz Ciechanowski1 1Department of Nephrology, Transplantology, and Internal Medicine, 2Department of Dental Surgery, 3Department of Medical Chemistry, 4Department of Forensic Medicine, 5Department of Pathomorphology, Pomeranian Medical University, 6Department of Physiology, Cytobiology, and Proteomics, West Pomeranian University of Technology, Szczecin, Poland Abstract: The structural proteins of renal tubular epithelial cells may become a target for the toxic metabolites of immunosuppressants. These metabolites can modify the properties of the proteins, thereby affecting cell function, which is a possible explanation for the mechanism of immunosuppressive agents' toxicity. In our study, we evaluated the effect of two immunosuppressive strategies on protein expression in the kidneys of Wistar rats. Fragments of the rat kidneys were homogenized after cooling in liquid nitrogen and then dissolved in lysis buffer. The protein concentration in the samples was determined using a protein assay kit, and the proteins were separated by two-dimensional electrophoresis. The obtained gels were then stained with Coomassie Brilliant Blue, and their images were analyzed to evaluate differences in protein expression. Identification of selected proteins was then performed using mass spectrometry. We found that the immunosuppressive drugs used in popular regimens induce a series of changes in protein expression in target organs. The expression of proteins involved in drug, glucose, amino acid, and lipid metabolism was pronounced. However, to a lesser extent, we also observed changes in nuclear, structural, and transport proteins' synthesis. Very slight differences

  6. Mutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapy

    Directory of Open Access Journals (Sweden)

    Nemecek R

    2016-07-01

    Full Text Available Radim Nemecek,1 Jitka Berkovcova,2 Lenka Radova,3 Tomas Kazda,4 Jitka Mlcochova,3 Petra Vychytilova-Faltejskova,1,3 Ondrej Slaby,1,3 Marek Svoboda1 1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic; 2Department of Oncological and Experimental Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 3Central European Institute of Technology, Masaryk University, Brno, Czech Republic; 4Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic Purpose: Although several molecular markers predicting resistance to cetuximab- or panitumumab-based therapy of metastatic colorectal cancer were described, mutations in RAS proto-oncogenes remain the only predictors being used in daily clinical practice. However, 35%–45% of wild-type RAS patients still do not respond to this anti-epidermal growth factor receptor (anti-EGFR monoclonal antibody-based therapy, and therefore the definition of other predictors forms an important clinical need. The aim of the present retrospective single-institutional study was to evaluate potential genes responsible for resistance to anti-EGFR therapy in relation to mutational analysis of primary versus metastatic lesions. Patients and methods: Twenty-four paired primary and corresponding metastatic tissue samples from eight nonresponding and four responding metastatic colorectal cancer patients treated with cetuximab-based therapy were sequenced using a next-generation sequencing panel of 26 genes involved in EGFR signaling pathway and colorectal carcinogenesis. Results: Mutational status of primary tumors and metastatic lesions was highly concordant in TP53, APC, CTNNB1, KRAS, PIK3CA, PTEN, and FBXW7 genes. Metastatic samples harbor significantly more mutations than primary tumors. Potentially negative predictive value of FBXW7 mutations in relationship to anti-EGFR treatment outcomes was confirmed

  7. Herpesvirus telomerase RNA (vTR with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis.

    Directory of Open Access Journals (Sweden)

    Benedikt B Kaufer

    2011-10-01

    Full Text Available Telomerase reverse transcriptase (TERT and telomerase RNA (TR represent the enzymatically active components of telomerase. In the complex, TR provides the template for the addition of telomeric repeats to telomeres, a protective structure at the end of linear chromosomes. Human TR with a mutation in the template region has been previously shown to inhibit proliferation of cancer cells in vitro. In this report, we examined the effects of a mutation in the template of a virus encoded TR (vTR on herpesvirus-induced tumorigenesis in vivo. For this purpose, we used the oncogenic avian herpesvirus Marek's disease virus (MDV as a natural virus-host model for lymphomagenesis. We generated recombinant MDV in which the vTR template sequence was mutated from AATCCCAATC to ATATATATAT (vAU5 by two-step Red-mediated mutagenesis. Recombinant viruses harboring the template mutation replicated with kinetics comparable to parental and revertant viruses in vitro. However, mutation of the vTR template sequence completely abrogated virus-induced tumor formation in vivo, although the virus was able to undergo low-level lytic replication. To confirm that the absence of tumors was dependent on the presence of mutant vTR in the telomerase complex, a second mutation was introduced in vAU5 that targeted the P6.1 stem loop, a conserved region essential for vTR-TERT interaction. Absence of vTR-AU5 from the telomerase complex restored virus-induced lymphoma formation. To test if the attenuated vAU5 could be used as an effective vaccine against MDV, we performed vaccination-challenge studies and determined that vaccination with vAU5 completely protected chickens from lethal challenge with highly virulent MDV. Taken together, our results demonstrate 1 that mutation of the vTR template sequence can completely abrogate virus-induced tumorigenesis, likely by the inhibition of cancer cell proliferation, and 2 that this strategy could be used to generate novel vaccine candidates

  8. Oscillatory dynamics in a model of vascular tumour growth - implications for chemotherapy

    Directory of Open Access Journals (Sweden)

    Maini PK

    2010-04-01

    differential equations (PDEs. Employing a combination of numerical and analytical techniques, we demonstrate how the spatio-temporal dynamics of the untreated tumour may influence its response to chemotherapy. Reviewers This manuscript was reviewed by Professor Zvia Agur and Professor Marek Kimmel.

  9. Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells

    Directory of Open Access Journals (Sweden)

    Niska K

    2015-02-01

    Full Text Available Karolina Niska,1 Katarzyna Pyszka,1 Cecylia Tukaj,2 Michal Wozniak,1 Marek Witold Radomski,3–5 Iwona Inkielewicz-Stepniak1 1Department of Medical Chemistry, 2Department of Electron Microscopy, Medical University of Gdansk, Gdansk, Poland; 3School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, The University of Dublin Trinity College, Dublin, Ireland; 4Kardio-Med Silesia, 5Silesian Medical University, Zabrze, Poland Abstract: Titanium dioxide (TiO2 nanoparticles (NPs are manufactured worldwide for a variety of engineering and bioengineering applications. TiO2NPs are frequently used as a material for orthopedic implants. However, to the best of our knowledge, the biocompatibility of TiO2NPs and their effects on osteoblast cells, which are responsible for the growth and remodeling of the human skeleton, have not been thoroughly investigated. In the research reported here, we studied the effects of exposing hFOB 1.19 human osteoblast cells to TiO2NPs (5–15 nm for 24 and 48 hours. Cell viability, alkaline phosphatase (ALP activity, cellular uptake of NPs, cell morphology, superoxide anion (O2•- generation, superoxide dismutase (SOD activity and protein level, sirtuin 3 (SIR3 protein level, correlation between manganese (Mn SOD and SIR, total antioxidant capacity, and malondialdehyde were measured following exposure of hFOB 1.19 cells to TiO2NPs. Exposure of hFOB 1.19 cells to TiO2NPs resulted in: (1 cellular uptake of NPs; (2 increased cytotoxicity and cell death in a time- and concentration-dependent manner; (3 ultrastructure changes; (4 decreased SOD and ALP activity; (5 decreased protein levels of SOD1, SOD2, and SIR3; (6 decreased total antioxidant capacity; (7 increased O2•- generation; and (8 enhanced lipid peroxidation (malondialdehyde level. The linear relationship between the protein level of MnSOD and SIR3 and between O2•- content and SIR3 protein level was observed. Importantly, the cytotoxic

  10. National surveillance of poultry diseases in Lebanon.

    Science.gov (United States)

    Barbour, E K; Hamadeh, S K; Hilan, C; Kallas, M; Eid, A; Sakr, W

    1997-12-01

    From 1992 to mid-1996, a national survey of poultry diseases in Lebanon was conducted. This surveillance included meat breeder, layer breeder, commercial layer and chicken broiler flocks. The history, signs, lesions and laboratory tests of poultry were used in the diagnosis of prevalent poultry diseases. Culture techniques were used to screen for bacterial diseases; serological techniques and, to a lesser extent, culture techniques were used to diagnose viral diseases; and both serological and culture techniques were used to diagnose Mycoplasma infections. The outbreaks of diseases detected in broiler breeder flocks and the number of such flocks experiencing these diseases were as follows: femoral head necrosis (6), egg-drop syndrome (3), reovirus-associated malabsorption syndrome (3), synovitis (Mycoplasma synoviae infection) (7), swollen head syndrome (SHS) (3), tenosynovitis (viral arthritis) (1), lymphoid leukosis (3), avian encephalomyelitis (1), fowl pox (1) and aortic rupture (1). The disease outbreaks detected in layer breeders were as follows: SHS (2), bumble foot (2), egg-drop syndrome (3) and avian infectious bronchitis (IB) (1). The disease outbreaks detected in commercial layer flocks were as follows: egg-drop syndrome (5), avian infectious laryngotracheitis (2), avian IB (nephrogenic strain) (1), malabsorption (1), avian tuberculosis (Mycobacterium avium) (1), Marek's disease (1), fowl pox (1), Salmonella enterica subsp. enterica Enteritidis infection (1), salpingitis (1) and Heterakis gallinae infestation (1). The disease outbreaks detected in broiler flocks were as follows: colibacillosis (40), infectious bursal disease (Gumboro disease) (15), malabsorption syndrome (8), avian infectious laryngotracheitis (8), paratyphoids (salmonellosis) (7), femoral head necrosis (8), SHS (6), avian mycoplasmosis (Mycoplasma gallisepticum infection) (6), synovitis (7), avian IB (6), botulism (1), avian encephalomyelitis (1) and gangrenous dermatitis (1). Diseases

  11. Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry

    Directory of Open Access Journals (Sweden)

    Santos-Martinez MJ

    2015-08-01

    Full Text Available Maria J Santos-Martinez,1,2,* Krzysztof A Tomaszewski,1,3,* Carlos Medina,1 Despina Bazou,4 John F Gilmer,1 Marek W Radomski1,5,6 1School of Pharmacy and Pharma­ceutical Sciences and Trinity Biomedical Sciences Institute, 2School of Medicine, Trinity College Dublin, University of Dublin, Dublin, Ireland; 3Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland; 4Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; 5Kardio-Med Silesia, Zabrze, 6Medical University of Silesia, Katowice, Poland *These authors contributed equally to this paper Background: Engineered nanoparticles (NPs can induce platelet activation and aggregation, but the mechanisms underlying these interactions are not well understood. This could be due in part to use of devices that study platelet function under quasi-static conditions with low sensitivity to measure platelet microaggregation. Therefore, in this study we investigated the pharmacological pathways and regulators of NP-induced platelet microaggregation under flow conditions at nanoscale using quartz crystal microbalance with dissipation (QCM-D and compared the data thus obtained with those generated by light aggregometry. Methods: Blood was collected from healthy volunteers, and platelet-rich plasma was obtained. Thrombin receptor-activating peptide, a potent stimulator of platelet function, and pharmacological inhibitors were used to modulate platelet microaggregation in the presence/absence of silica (10 nm and 50 nm and polystyrene (23 nm NPs. Light aggregometry was used to study platelet aggregation in macroscale. Optical, immunofluorescence, and scanning electron microscopy were also used to visualize platelet aggregates. Results: Platelet microaggregation was enhanced by thrombin receptor-activating peptide, whereas prostacyclin, nitric oxide donors, acetylsalicylic acid, and phenanthroline, but not

  12. 'Genome order index' should not be used for defining compositional constraints in nucleotide sequences - a case study of the Z-curve

    Directory of Open Access Journals (Sweden)

    Josić Krešimir

    2010-02-01

    Full Text Available Abstract Background The Z-curve is a three dimensional representation of DNA sequences proposed over a decade ago and has been extensively applied to sequence segmentation, horizontal gene transfer detection, and sequence analysis. Based on the Z-curve, a "genome order index," was proposed, which is defined as S = a2+ c2+t2+g2, where a, c, t, and g are the nucleotide frequencies of A, C, T, and G, respectively. This index was found to be smaller than 1/3 for almost all tested genomes, which was taken as support for the existence of a constraint on genome composition. A geometric explanation for this constraint has been suggested. Each genome was represented by a point P whose distance from the four faces of a regular tetrahedron was given by the frequencies a, c, t, and g. They claimed that an inscribed sphere of radius r = 1/ contains almost all points corresponding to various genomes, implying that S r2. The distribution of the points P obtained by S was studied using the Z-curve. Results In this work, we studied the basic properties of the Z-curve using the "genome order index" as a case study. We show that (1 the calculation of the radius of the inscribed sphere of a regular tetrahedron is incorrect, (2 the S index is narrowly distributed, (3 based on the second parity rule, the S index can be derived directly from the Shannon entropy and is, therefore, redundant, and (4 the Z-curve suffers from over dimensionality, and the dimension stands for GC content alone suffices to represent any given genome. Conclusion The "genome order index" S does not represent a constraint on nucleotide composition. Moreover, S can be easily computed from the Gini-Simpson index and be directly derived from entropy and is redundant. Overall, the Z-curve and S are over-complicated measures to GC content and Shannon H index, respectively. Reviewers This article was reviewed by Claus Wilke, Joel Bader, Marek Kimmel and Uladzislau Hryshkevich (nominated by Itai Yanai.

  13. School students "Catch a Star"!

    Science.gov (United States)

    2007-04-01

    School students from across Europe and beyond have won prizes in an astronomy competition, including the trip of a lifetime to one of the world's most powerful astronomical observatories, on a mountaintop in Chile. ESO, the European Organisation for Astronomical Research in the Southern Hemisphere, together with the European Association for Astronomy Education (EAAE), has just announced the winners of the 2007 "Catch a Star!" competition. ESO PR Photo 21/07 "Catch a Star!" is an international astronomy competition for school students, in which students are invited to 'become astronomers' and explore the Universe. The competition includes two categories for written projects on astronomical themes, to ensure that every student, whatever their level, has the chance to enter and win exciting prizes. For the artistically minded, "Catch a Star!" also includes an astronomy-themed artwork competition. Students from 22 countries submitted hundreds of written projects and pieces of artwork. "The standard of entries was most impressive, and made the jury's task of choosing winners both enjoyable and difficult! We hope that everyone, whether or not they won a prize, had fun taking part, and learnt some exciting things about our Universe", said Douglas Pierce-Price, Education Officer at ESO. The top prize, of a week-long trip to Chile to visit the ESO Very Large Telescope (VLT) on Paranal, was won by students Jan Mestan and Jan Kotek from Gymnazium Pisek in the Czech Republic, together with their teacher Marek Tyle. Their report on "Research and Observation of the Solar Eclipse" told how they had studied solar eclipses, and involved their fellow students in observations of an eclipse from their school in 2006. The team will travel to Chile and visit the ESO VLT - one of the world's most powerful optical/infrared telescopes - where they will meet astronomers and be present during a night of observations on the 2600m high Paranal mountaintop. "It's fantastic that we will see the

  14. Vladimir Prelog i Zavod za organsku kemiju

    Directory of Open Access Journals (Sweden)

    Jakopčić, K.

    2007-03-01

    Full Text Available The Department of organic chemistry was founded on October 1st, 1922 as part of the Chemical Engineering Department of the High Technical School in Zagreb. The first-appointed professor of organic chemistry was Ivan Marek, formerly the professor at the School of Trade in Zagreb. The High Technical School with all its departments was soon (1926/27 incorporated into the University of Zagreb and became the nucleus of the Technical Faculty. The management of the faculty was fully aware of the necessity to engage the best scientists in the field as faculty professors. As far as organic chemistry was concerned, there was no better choice in the mid 1930's, than to invite young but already recognized organic chemist Dr. Vladimir Prelog to join the staff and to succeed professor Marek, who retired in 1935. Dr. Prelog did not hesitate to accept the invitation and was eager to continue his scientific work in an academic laboratory in Zagreb. At the time of the invitation, Dr. Prelog was engaged in a small laboratory synthesizing special samples of rare chemicals to be sold through the chemical store "Dřiza" in Prague. There he was provided the modest opportunity to carry on his own research, and together with Rudolf Lukeš and Emil Votoček, published a number of papers concerning organic synthesis and chemistry of natural products. Elected in Zagreb for the lectureship of the assistant professor in organic chemistry, Prelog started teaching as early as in the summer semester of 1934/35. The ingenious and bright lecturing of young professor Prelog inspired his students, and many of them were attracted to organic chemistry. On the other hand, the working conditions in the disposable laboratory of the Organic Chemistry Department were too modest to accept a number of students. The budget was so small that it only covered tuition, while there was no research fund at the faculty. Luckily, Dr. Prelog did not hesitate to accept an offer for scientific co

  15. PREFACE: International Conference on Optics of Excitons in Confined Systems

    Science.gov (United States)

    Viña, Luis; Tejedor, Carlos; Calleja, José M.

    2010-01-01

    ), France (41), Spain (33), UK (24), Switzerland (21), Italy (14), The Netherlands (12), USA (11), other (23). The conference was made possible by generous sponsors, whom we thank earnestly: Universidad Autónoma de Madrid, Spanish Ministry of 'Educación y Ciencia', Consejo Superior de Investigaciones Científicas, European Union (ITN- 235114), Europhysics Letters, Semiconductor Science and Technology, Consolider Research Project 'Quantum Optical Information Technology', Lasing S A, Newport, Innova Scientific, Foundation Madrid-2016 and European Physical Society. We would like to acknowledge the members of the Organizing and Program Committees, who are responsible for the success of the Conference (names are listed below). Finally, the authors are thanked for the quality of their contributions. Luis Viña Carlos Tejedor José M Calleja EDITORS Organizing Committee Luis Viña-Chair, Universidad Autónoma de Madrid María D Martín-Scientific Secretary, Universidad Autónoma de Madrid José M Calleja, Universidad Autónoma de Madrid Luisa González, Instituto de Microelectrónica de Madrid Herko van der Meulen, Universidad Autónoma de Madrid Enrique Calleja, Instituto de Sistemas Optoelectrónicos y Microtecnología Madrid Daniele Sanvitto, Universidad Autónoma de Madrid Program Committee Carlos Tejedor-Chair, Universidad Autónoma de Madrid Israel Bar-Joseph, Weizmann Institute of Science Jeremy J Baumberg, Cambridge University Manfred Bayer, Universität Dortmund Jacqueline Bloch, Laboratoire de Photonique et de Nanostructures - CNRS Wolfgang Langbein, Cardiff University Marek Potemski, Grenoble High Magnetic Field Laboratory Antonio Quattropani, Ecole Polytechnique Fédérale de Lausanne Salvatore Savasta, Università di Messina Vincenzo Savona, Ecole Polytechnique Fédérale de Lausanne David Snoke, University of Pittsburgh Jerome Tignon, Ecole Normale Superieure Paris

  16. Mécano-Stimulation™ of the skin improves sagging score and induces beneficial functional modification of the fibroblasts: clinical, biological, and histological evaluations

    Directory of Open Access Journals (Sweden)

    Humbert P

    2015-02-01

    Full Text Available Philippe Humbert,1,2 Ferial Fanian,1,2 Thomas Lihoreau,1,2 Adeline Jeudy,1,2 Ahmed Elkhyat,1,2 Sophie Robin,3 Carol Courderot-Masuyer,3 Hélène Tauzin,3 Christine Lafforgue,1,2,4 Marek Haftek5 1Research and Studies Center on the Integument (CERT, Department of Dermatology, Clinical Investigation Center (CIC 1431, Besançon University Hospital; 2INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France; 3SARL BIOEXIGENCE, Besançon, France; 4Dermopharmacology and Cosmetology Unit, University of Paris Sud, France; 5University of Lyon 1, EA4169, Experimental, clinical and therapeutic aspects of the skin barrier function, INSERM US7 – CNRS UMS3453, Lyon, France Background: Loss of mechanical tension appears to be the major factor underlying decreased collagen synthesis in aged skin. Numerous in vitro studies have shown the impact of mechanical forces on fibroblasts through mechanotransduction, which consists of the conversion of mechanical signals to biochemical responses. Such responses are characterized by the modulation of gene expression coding not only for extracellular matrix components (collagens, elastin, etc. but also for degradation enzymes (matrix metalloproteinases [MMPs] and their inhibitors (tissue inhibitors of metalloproteinases [TIMPs]. A new device providing a mechanical stimulation of the cutaneous and subcutaneous tissue has been used in a simple, blinded, controlled, and randomized study. Materials and methods: Thirty subjects (aged between 35 years and 50 years, with clinical signs of skin sagging, were randomly assigned to have a treatment on hemiface. After a total of 24 sessions with Mécano-Stimulation™, biopsies were performed on the treated side and control area for in vitro analysis (dosage of hyaluronic acid, elastin, type I collagen, MMP9; equivalent dermis retraction; GlaSbox®; n=10 and electron microscopy (n=10. Furthermore, before and after the treatment, clinical evaluations and self

  17. PREFACE: 12th International Symposium on Multiscale, Multifunctional and Functionally Graded Materials (FGM 2012)

    Science.gov (United States)

    Zhou, Zhangjian; Li, Jingfeng; Zhang, Lianmeng; Ge, Changchun

    2013-03-01

    Technology, and was supported by National Natural Science Foundation of China. On behalf of the organizing committee of FGM-2012, I express my great appreciation to their support of the symposium. Nearly 100 scholars and students from Japan, Brazil, Germany, Russia, United States of America, Portugal, France, Switzerland, Turkey, Singapore, China, and so on, attended FGM-2012, and 57 of the presented papers were collected and selected for publication. The subjects of these papers cover simulation and characterization, advanced fabrication technology, novel application of FGM and layer materials. I cordially thank all of the authors and attendees for their support, and my appreciation is also given to the advisory committee, organizing committee, and the conference volunteers for their hard work. Professor Zhangjian Zhou Proceedings Editor Beijing, December 2012 Committees International Advisory Committee Professor Glaucio H Paulino, USA Professor Marek-Jerzy Pindera, USA Professor Jeong-Ho Kim, USA Professor Emer Fazil Erdogan, USA Professor Dr Monika Willert-Porada, Germany Professor Emer Wolfgang G J Bunk, Germany Professor Omer Van Der Biest, Belgium Professor Michael M Gasik, Finland Professor Evgeny Levashov, Russia Professor Lianmeng Zhang, China Professor Qingjie Zhang, China Professor Wei Pan, China Professor Chang-Chun Ge, China Professor Jing-Feng Li, China Professor Zhangjian Zhou, China Associate Professor Serkan Dag, Turkey Professor Fernando A Rochinha, Brazil Professor Emilio C N Silva, Brazil Professor Luis August Rocha, Portugal Dr Sasa Novak, Slovenia Dr Masayuki Niino, Japan Professor Akira Kawasaki, Japan Professor Ichiro Shiota, Japan Dr Akinaga Kumakawa, Japan Dr Yoshikazu Shinohara, Japan Professor Kiyotaka Matsuura, Japan Professor Yoshinari Miyamoto, Japan Professor Takashi Goto, Japan Professor Yoshimi Watanabe, Japan Professor Kazuhiro Hasezaki, Japan Professor Soshu Kirihara, Japan Professor Emer Toshio Hirai, Japan Mr Choji Endou, Japan Dr

  18. In Ovo Vaccination with Turkey Herpesvirus Hastens Maturation of Chicken Embryo Immune Responses in Specific-Pathogen-Free Chickens.

    Science.gov (United States)

    Gimeno, Isabel M; Faiz, Nik M; Cortes, Aneg L; Barbosa, Taylor; Villalobos, Tarsicio; Pandiri, Arun R

    2015-09-01

    Administration of Marek's disease (MD) vaccines in ovo has become a common practice for the poultry industry. Efficacy of MD vaccines is very high, even though they are administered to chicken embryos that are immunologically immature. We have recently demonstrated that in ovo vaccination with turkey herpesvirus (HVT) results in increased activation of T cells at hatch. Our previous results suggested that in ovo vaccination with HVT might have a positive impact not only on MD protection but also on the overall maturity of the developing immune system of the chicken (Gallus gallus domesticus). The objective of this study was to evaluate the effect of administration of HVT at 18 days of embryonation (ED) on the maturation of the embryo immune system. Four experiments were conducted in Specific-Pathogen-Free Avian Supplies (SPAFAS) chickens to evaluate the effect of administration of HVT at 18 ED on the splenic cell phenotypes at day of age (experiment 1) and on the ability of 1-day-old chickens to respond to various antigens compared with older birds (experiments 2 and 3). In addition, a fourth experiment was conducted to elucidate whether administration of other serotype's MD vaccines (CVI988 and SB-1) at 18 ED had the same effect as HVT on the spleen cell phenotypes at day of age. Our results demonstrated that 1-day-old chickens that had received HVT in ovo (1-day HVT) had higher percentages of CD45+, MHC-I+, CD45+MHC-I+, CD3+, MHC-II+, CD3+MHC-II+, CD4+, CD8+, and CD4+CD8+ cells in the spleen than 1-day-old sham-inoculated chickens (1-day sham). Moreover, spleens of 1-day HVT chickens had greater percentages of CD45+MHC-I+ cells and equal or greater numbers of CD4+CD8- and CD4-CD8+ cells than older unvaccinated chickens. In addition, administration of HVT at 18 ED rendered chicks at hatch more responsive to unrelated antigens such as concavalin A, phytohemagglutinin-L, and keyhole limpet hemocyanin. Administration of MD vaccines of other serotypes had an effect

  19. Bark vegetation contributes to nitrous oxide (N2O) deposition by mature beech trees

    Science.gov (United States)

    Machacova, Katerina; Maier, Martin; Svobodova, Katerina; Lang, Friederike; Urban, Otmar

    2017-04-01

    compared to stem deposition rates measured under the field conditions. Specifically, it was -1.3, -2.0, and -1.8 μg N2O m-2 h-1 for algae, lichens, and mosses, respectively. Therefore, it seems that bark vegetation is at least co-responsible for the observed unique deposition of N2O by beech trees. Acknowledgement This research was supported by the Czech Academy of Sciences and the German Academic Exchange Service (project DAAD-15-03), the Czech Science Foundation (17-18112Y), National Programme for Sustainability I (LO1415), CzeCOS (LM2015061) and DFG project (MA 5826/2-1). We thank Marek Jakubik, Sinikka Paulus, Ellen Halaburt and Sally Haddad for technical and field support.

  20. Foreword

    International Nuclear Information System (INIS)

    Sujkowski, Z.

    2006-01-01

    formation of superconducting regions in layers of MgB 2 obtained by implantation of magnesium ions into a boron substrate followed by intense pulsed plasma treatment, and on the first evidence of ν μ oscillation in an accelerator-based experiment. In the technical category, the winning work was on large scale production of straw tube modules for the LHCb experiment at CERN together with the design of basic hardware modules concerning overall control of this experiment. Another technical achievement was that the system for brachytherapy of brain tumors based on the Photon Needle X-ray generator has entered the phase of clinical testing. Worth mentioning is also the work of our DESY team on the leptoproduction in a nuclear medium as well as that of our KASCADE collaboration participants on the detection and imaging of atmospheric radio flashes from cosmic ray air showers (see Nature 435 (2005) 313) Participation in the EURATOM fusion program was continued. The International Conference Plasma 2005 was organized by our Plasma Physics Department. Our activity in the field of general education and popularization of science has increased. As usual in such cases, we owe this to a few enthusiasts. My thanks for this go to Leszek Nowicki, Jacek Jagielski, Marek Pawlowski, Jacek Szabelski and many others as well as to our Training Department led by Professor Ludwik Dobrzynski. There was a small but significant change in the organization of the Institute: the formation of the Information Technology Division headed by Jacek Szlachciak. This brings a degree of order and expertise into the rapidly developing field with even more rapidly growing needs, possibilities and expectations. We all wish Jacek and his colleagues every successes in carrying out their tasks. The Reader of our Annual Reports may notice a certain novelty in this year's issue: the expanded general part including some details about events which we judge significant. I hope the Reader will find this part as well as the

  1. PREFACE: EDS2010 Preface

    Science.gov (United States)

    Heggie, Malcolm I.

    2011-03-01

    the afternoon outing to Arundel Castle and dinner in the evening at Wiston House, a mansion of Tudor origin near Steyning, West Sussex. So a short audience-participation seminar was held in the conference room of the manor, covering the history of dislocations and the history of the conference series. We were also able to extend the appreciation of the life of Prof. Yuri Ossipyan (15 Feb 1931 - 10 Sep 2008) briefly given at EDS2008. EDS2010 continued the drive into graphene-based materials with a session devoted to them, and it gave immense pleasure to many of us who were his former students to dedicate a session to the work of Professor R Jones. We are grateful to his present and former co-workers who came and presented an impressive perspective on their work with him and a vision of a vigorous future for him in his retirement and for AIMPRO, the current Density Functional Theory code that derives from the one he established with his former student, Dr Patrick Briddon. For EDS2010 we made two minor modifications to the appearance of the conference: a central webpage www.eds-conferences.org, ably managed by our webmaster, Dr Gemma Haffenden, and a Facebook page, "EDS conference series", which Dr Amy Gandy runs enthusiastically. Amongst other things the conference photographs appear here. "I like this". In fact, currently 22 FB-ers "like this" and I am sure it will grow. Finally, it is a pleasure to acknowledge the significant contributions of Co-Chair, Prof. Marek Skowronski, Conference Manager, Dr Christopher Latham, and the editors of this volume, Drs Jon Goss and Chris Ewels, who in turn wish to thank Dr Alexis Vlandas for his help proof reading the articles. We all wish the best of luck to Prof. Philomela Khomninou and her team in the organisation of EDS2012.

  2. Pea seeds (Pisum sativum, faba beans (Vicia fabavar. minor and lupin seeds (Lupinus albus var. multitalia as protein sources in broiler diets: effect of extrusion on growth performance

    Directory of Open Access Journals (Sweden)

    Gianfranco Piva

    2010-01-01

    Full Text Available The effect of extrusion of pea seeds (Pisum sativum (PS, faba bean (Vicia faba, variety minor (FB and lupin seeds (Lupinus albus, variety multitalia (LS on broiler performance were evaluated. Four hundred sixty two 1d-old Ross male chicks, Marek vaccinated, were randomly assigned to seven dietary treatments (3 pens per treatment/22 birds per pen. Chicks were floor housed, ad libitum fed isocaloric and isonitrogenous diets and had free access to water. Artificial light was provided 10 h/d. The bulk of the base diet (control diet was corn (48.8%, 53.7% and 57%, solvent-extracted soy- bean meal (42.8%, 37.3% and 33.4%, corn oil (4.4%, 5.2% and 6.3%, plus synthetic amino acids, minerals, trace minerals and vitamins, respectively for the 1-10d-old, 11-28d-old and 29 to 42d-old growing periods. The amounts of PS, FB and LS used on an as fed basis were: PS and extruded PS (EPS: 353 (1-10d-old, 356 (11-28d-old and 350 (29- 42d-old g/kg; FB and extruded FB (EFB: 479 (1-10d-old, 497 (11-28d-old and 500 (29-42d old g/kg; LS and extrud- ed LS (ELS: 360 (1-10d-old and 300 (11-42d-old g/kg. High levels of pea (350 g/kg and faba bean (500 g/kg did not show negative effects on body weight gain (BWG and bird feed intake compared to control. Lupin at the 300 g/kg level reduced (P< 0.05 the BWG during the finishing period (22 to 42 d, however the effect disappeared over the whole experimental period (1-42 d compared to the control group. The ELS group had a lower (P< 0.01 feed intake com- pared to the control group and to the LS group. The feed conversion rate (FCR was similar among groups for the whole experimental period; however during the grower period the FCR was higher (P< 0.05 for the PS, FB and EFB groups com- pared to the control group. Birds consuming the PS diet had a reduced (P< 0.05 eviscerated carcass yield compared to the control group. The breast meat percent yield was higher (P< 0.01 for birds consuming the FB and EFB diets compared to the control

  3. Proceedings of the International Symposium on Topological Aspects of Critical Systems and Networks

    Science.gov (United States)

    Yakubo, Kousuke; Amitsuka, Hiroshi; Ishikawa, Goo; Machino, Kazuo; Nakagaki, Toshiyuki; Tanda, Satoshi; Yamada, Hideto; Kichiji, Nozomi

    2007-07-01

    I. General properties of networks. Physics of network security / Y.-C. Lai, X. Wand and C. H. Lai. Multi-state interacting particle systems on scale-free networks / N. Masuda and N. Konno. Homotopy Reduction of Complex Networks 18 / Y. Hiraoka and T. Ichinomiya. Analysis of the Susceptible-Infected-Susceptible Model on Complex Network / T. Ichinomiya -- II. Complexity in social science. Innovation and Development in a Random Lattice / J. Lahtinen. Long-tailed distributions in biological systems: revisit to Lognormals / N. Kobayashi ... [et al.]. Two-class structure of income distribution in the USA:exponential bulk and power-law tail / V. M. Yakovenko and A. Christian Silva. Power Law distributions in two community currencies / N. Kichiji and M. Nishibe -- III. Patterns in biological objects. Stoichiometric network analysis of nonlinear phenomena in rection mechanism for TWC converters / M. Marek ... [et al.]. Collective movement and morphogenesis of epithelial cells / H. Haga and K. Kawabata. Indecisive behavior of amoeba crossing an environmental barrier / S. Takagi ... [et al.]. Effects of amount of food on path selection in the transport network of an amoeboid organism / T. Nakagaki ... [et al.]. Light scattering study in double network gels / M. Fukunaya ... [et al.].Blood flow velocity in the choroid in punctate inner choroidopathy and Vogt-Koyanagi-Harada disease; amd multifractal analysis of choroidal blood flow in age-related macular degeneration / K. Yoshida ... [et al.]. Topological analysis of placental arteries: correlation with neonatal growth / H. Yamada and K. Yakubo -- IV. Criticality in pure and applied physics. Droplets in Disordered Metallic Quantum Critical Systems / A. H. Castro Neto and B. A. Jones. Importance of static disorder and inhomogeneous cooperative dynamics in heavy-fermion metals / O. O. Bernal. Competition between spin glass and Antiferromagnetic phases in heavy fermion materials / S. Sullow. Emergent Phases via Fermi surface

  4. Prospective unmasked randomized evaluation of the iStent inject® versus two ocular hypotensive agents in patients with primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Fea AM

    2014-05-01

    Full Text Available Antonio M Fea,1 Jose I Belda,2 Marek Rękas,3 Anselm Jünemann,4 Lydia Chang,5 Luis Pablo,6 Lilit Voskanyan,7 L Jay Katz81Università degli Studi di Torino, Clinica Oculistica, Torino, Italy; 2Hospital Torrevieja Salud, UTE, Servicio de Oftalmologia, Alicante, Spain; 3Military Institute of Medicine, Department of Ophthalmology, Warsaw, Poland; 4Universitätsaugenklinik, Erlangen, Germany; 5Hinchingbrooke Hospital NHS Trust and Moorfields Bedford Hospital NHS Trust, United Kingdom; 6Hospital Universitario Miguel Servet, Servicio Oftalmologico, Zaragoza, Spain; 7SV Malayan Ophthalmological Center, Yerevan, Armenia; 8Wills Eye Institute, Jefferson Medical College, Philadelphia, PA, USAPurpose: The purpose of this study was to compare outcomes of subjects with open-angle glaucoma (OAG not controlled on one medication who underwent either implantation of two iStent inject® trabecular micro-bypass devices or received medical therapy consisting of a fixed combination of latanoprost/timolol.Patients and methods: Of 192 subjects who qualified for the study and were enrolled, 94 were randomized to surgery with implantation of two iStent inject® devices in the treated eye and 98 to receive medical therapy.Results: At the month 12 visit, 94.7% of eyes (89/94 in the stent group reported an unmedicated intraocular pressure (IOP reduction of ≥20% versus baseline unmedicated IOP, and 91.8% of eyes (88/98 in the medical therapy group reported an IOP reduction ≥20% versus baseline unmedicated IOP. A 17.5% between-group treatment difference in favor of the iStent inject group was statistically significant (P=0.02 at the ≥50% level of IOP reduction. An IOP ≤18 mmHg was reported in 92.6% of eyes (87/94 in the iStent inject group and 89.8% of eyes (88/98 in the medical therapy group. Mean (standard deviation IOP decreases from screening of 8.1 (2.6 mmHg and 7.3 (2.2 mmHg were reported in the iStent inject and medical therapy groups, respectively. A high

  5. Nitrous oxide fluxes from forest floor, tree stems and canopies of boreal tree species during spring

    Science.gov (United States)

    Haikarainen, Iikka; Halmeenmäki, Elisa; Machacova, Katerina; Pihlatie, Mari

    2017-04-01

    were 1.4 and 2.2 mg N2O ha-1 h-1, respectively, while the forest floor was a sink of -6.1 mg N2O ha-1 h-1. At the mineral soil site the upscaled N2O emissions from birch trees and forest floor were 3.6 and 8.9 mg N2O ha-1 h-1, respectively, indicating that the emissions from trees significantly contribute to the N2O emissions from boreal forests. The results also indicate that tree canopies contributed up to 89% of the whole-tree N2O emissions. Our findings demonstrate that we urgently need more studies focusing on leaf-level N2O exchange in forest ecosystems. Acknowledgement This research was financially supported by the National Programme for Sustainability I (LO1415), Czech Science Foundation (17-18112Y), ENVIMET (CZ.1.07/2.3.00/20.0246) , Emil Aaltonen Foundation, Academy of Finland Research Fellow projects (292699, 263858, 288494), The Academy of Finland Centre of Excellence (projects 1118615, 272041), and ICOS-Finland (281255). We thank Hyytiälä SMEAR II station staff and Marek Jakubik for technical support.

  6. 6th conference on Advances in Optoelectronics and Micro/nano-optics

    International Nuclear Information System (INIS)

    2017-01-01

    would like to thank all participants of this conference, and particularly the authors of all accepted papers for their high quality and fruitful contributions. We do hope that this volume will be beneficial for readers to their future research endeavours and careers. We also gratefully acknowledge tremendous efforts and dedication of many individuals and all the Editorial Board members in IOP Publishing for their support in producing the proceedings of this event. Sincerely, Yiping Cui Conference Co-Chair CONFERENCE OFFICIALS Conference Co-Chairs Yiping Cui Southeast University, China Xiaocong Yuan Shenzhen University, China Shining Zhu Nanjing University, China Executive Chair Zhuyuan Wang Southeast University, China Technical Program Committee Guanghui Chen China Electronics Technology Group Corporation, China Yiping Cui Southeast University, China Qihuang Gong Peking University, China Min Gu Swinburne University of Technology, Australia Satoshi Kawata Osaka University, Japan Gong-Ru Lin National Taiwan University, Taiwan, China Xu Liu Zhejiang University, China Yanqing Lu Nanjing University, China Ting Mei Northwestern Polytechnical University, China Min Qiu Zhejiang University, China Marek Samoc Wroclaw University of Technology, Poland Colin Sheppard Italian Institute of Technology, Italy Charles Surya Hong Kong Polytechnic University, China Katarina Svanberg Lund University, Sweden Sune Svanberg Lund University, Sweden Jinghua Teng IMRE, Singapore Dinping Tsai Academia Sinica, Taiwan, China Zhuyuan Wang Southeast University, China Jingjun Xu Nankai University, China Baoli Yao Xi’an Institute of Optics and Precision Mechanics, China Xiaocong Yuan Shenzhen University, China Qiwen Zhan University of Dayton, USA Shining Zhu Nanjing University, China (paper)

  7. Committees and organizers

    Science.gov (United States)

    2011-07-01

    Chairman:Jozef Spałek (Kraków) Program Committee:Stephen Blundell (Oxford), J Michael D Coey (Dublin), Dominique Givord (Grenoble), Dariusz Kaczorowski (Wrocław), Roman Micnas (Poznań), Marek Przybylski (Halle), Ludiwig Schultz (Dresden), Vladimir Sechovsky (Prague), Jozef Spałek (Kraków), Henryk Szymczak (Warszawa), Manuel Vázquez (Madrid) Publication Committee:Dariusz Kaczorowski, Robert Podsiadły, Jozef Spałek, Henryk Szymczak, Andrzej Szytuła Local committee:Maria Bałanda, Anna Majcher, Robert Podsiadły, Michał Rams, Andrzej Ślebarski, Krzysztof Tomala Editors of the Proceedings:Jozef Spałek, Krzysztof Tomala, Danuta Goc-Jagło, Robert Podsiadły, Michał Rams, Anna Majcher Plenary, semi-plenary and tutorial speakers:Ernst Bauer (Wien)Stephen Blundell (Oxford)J Michael D Coey (Dublin)Russell P Cowburn (London)Burkard Hillebrands (Kaiserslautern)Claudine Lacroix (Grenoble)Lluís Mañosa (Barcelona)María del Carmen Muñoz (Madrid)Bernard Raveau (Caen)Pedro Schlottmann (Tallahassee)Frank Steglich (Dresden)Oliver Waldmann (Freiburg) Invited speakers within symposia: R Ahuja (Uppsala)A Kirilyuk (Nijmegen) M Albrecht (Vienna)L Theil Kuhn (Roskilde) K Bärner (Göttingen)J Liu (Dresden) U Bovensiepen (Duisburg)G Lorusso (Modena) V Buchelnikov (Chelyabinsk)M M Maska (Katowice) B Chevalier (Bordeaux)Y Mukovskii (Moscow) O Chubykalo-Fesenko (Madrid)M Pannetier-Lecoeur (Saclay) A V Chumak (Kaiserslautern)G Papavassiliou (Athens) J M D Coey (Dublin)K R Pirota (Campinas) B Dabrowski (DeKalb)P Przyslupski (Warszawa) S Das (Aveiro)M Reiffers (Košice) A del Moral (Zaragoza)K Sandeman (London) V E Demidov (Muenster)D Sander (Halle) B Djafari-Rouhani (Lille)M Sawicki (Sendai/Warsaw) H A Dürr (Menlo Park)J Schaefer (Würzburg) J Fassbender (Dresden)H Schmidt (Wetzikon) J Fontcuberta (Barcelona)J Spałek (Kraków) V Garcia (Orsay)L Straka (Helsinki) J N Gonçalves (Aveiro)A Szewczyk (Warszawa) M E Gruner (Duisburg)Y Taguchi (Wako) G Gubbiotti (Perugia)A Thiaville

  8. Dysfunction of the thyroid gland during amiodarone therapy: a study of 297 cases

    Directory of Open Access Journals (Sweden)

    Czarnywojtek A

    2016-04-01

    Full Text Available Agata Czarnywojtek,1,2,* Maria Teresa Płazińska,3,* Małgorzata Zgorzalewicz-Stachowiak,4 Kosma Woliński,1 Adam Stangierski,1 Izabela Miechowicz,5 Joanna Waligórska-Stachura,1 Paweł Gut,1 Leszek Królicki,3 Maja Zioncheck,6 Marek Ruchała1 1Department of Endocrinology, Metabolism and Internal Medicine, 2Department of Pharmacology, Poznan University of Medical Sciences, Poznan, 3Nuclear Medicine Department, Medical University of Warsaw, Warsaw, 4Department of Health Prophylaxis, Laboratory of Medical Electrodiagnostics, 5Department of Computer Science and Statistics, 6Poznan University of Medical Sciences, Poznan, Poland *These authors contributed equally to this work Aim: This study aims to explore and compare the efficacy of radioiodine treatment (RIT in hyperthyroid and euthyroid patients who have been treated with amiodarone (AM in the past or are currently undergoing AM treatment. Clinical observation of a group of patients with amiodarone-induced hypothyroidism during a 12-month follow-up period was used for comparison.Design: This was a observational, two-centered study. Patients were assessed at baseline and at 2 months, 6 months, 8 months, and 12 months after RIT.Patients: Group A: At baseline (61 males [M] and 17 females [F], mean age 50±19 years, there were 78 euthyroid patients with cardiac arrhythmias, who were treated with AM and developed amiodarone-induced thyrotoxicosis, and currently require retreatment with AM. Group B: Hyperthyroid patients (92 M and 26 F, mean age 72±11.8 years after AM therapy in the past. Group C: Hyperthyroid patients (66 M and 13 F, mean age 63.9±13.2 years currently treated by AM. Group D: Hypothyroid patients (6 M and 16 F, mean age 61.4±10.4 years after AM therapy. The patients from Groups A, B, and C were retreated with AM after ~3–6 weeks of RIT.Results: In Group A, after 12 months of RIT therapy, recurrent thyrotoxicosis was observed in six (7.7% cases, and persistent

  9. Reactor Dosimetry State of the Art 2008

    Science.gov (United States)

    Voorbraak, Wim; Debarberis, Luigi; D'Hondt, Pierre; Wagemans, Jan

    2009-08-01

    Oral session 1: Retrospective dosimetry. Retrospective dosimetry of VVER 440 reactor pressure vessel at the 3rd unit of Dukovany NPP / M. Marek ... [et al.]. Retrospective dosimetry study at the RPV of NPP Greifswald unit 1 / J. Konheiser ... [et al.]. Test of prototype detector for retrospective neutron dosimetry of reactor internals and vessel / K. Hayashi ... [et al.]. Neutron doses to the concrete vessel and tendons of a magnox reactor using retrospective dosimetry / D. A. Allen ... [et al.]. A retrospective dosimetry feasibility study for Atucha I / J. Wagemans ... [et al.]. Retrospective reactor dosimetry with zirconium alloy samples in a PWR / L. R. Greenwood and J. P. Foster -- Oral session 2: Experimental techniques. Characterizing the Time-dependent components of reactor n/y environments / P. J. Griffin, S. M. Luker and A. J. Suo-Anttila. Measurements of the recoil-ion response of silicon carbide detectors to fast neutrons / F. H. Ruddy, J. G. Seidel and F. Franceschini. Measurement of the neutron spectrum of the HB-4 cold source at the high flux isotope reactor at Oak Ridge National Laboratory / J. L. Robertson and E. B. Iverson. Feasibility of cavity ring-down laser spectroscopy for dose rate monitoring on nuclear reactor / H. Tomita ... [et al.]. Measuring transistor damage factors in a non-stable defect environment / D. B. King ... [et al.]. Neutron-detection based monitoring of void effects in boiling water reactors / J. Loberg ... [et al.] -- Poster session 1: Power reactor surveillance, retrospective dosimetry, benchmarks and inter-comparisons, adjustment methods, experimental techniques, transport calculations. Improved diagnostics for analysis of a reactor pulse radiation environment / S. M. Luker ... [et al.]. Simulation of the response of silicon carbide fast neutron detectors / F. Franceschini, F. H. Ruddy and B. Petrović. NSV A-3: a computer code for least-squares adjustment of neutron spectra and measured dosimeter responses / J. G

  10. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    Science.gov (United States)

    Nielsch, Kornelius

    2012-01-01

    -review, with the aim to raise the quality of our content, three years later the number of published articles has remained stable at around 220 per year, whilst the number of downloads and citations to the journal has grown. In 2011, three topical issues have been published, on: (Nano)characterization of semiconductor materials and structures (Guest Editor: Alberta Bonanni, University of Linz, Austria) Flexible OLEDs and organic electronics (Guest Editors: Jang-Joo Kim, Min-Koo Han, Cambridge University, UK, and Yong-Young Noh, Seoul National University, Korea) From heterostructures to nanostructures: an 80th birthday tribute to Zhores Alferov (Guest Editor: Dieter Bimberg, Technische Universität Berlin, Germany) For the coming years, I will strongly support that the number of published topical issues will continue on the same level or slightly rise. SST has planned the publication of the following topical issues for 2012: Non-polar and semipolar nitride semiconductors (Guest Editors: Jung Han, Yale University, USA, and Michael Kneissl, Technische Universität Berlin, Germany) Topological insulators (Guest Editors: Alberto Morpurgo, Université de Genève, Switzerland and Björn Trauzettel, Universität Basel, Switzerland) Atomic layer deposition (Guest Editor: Marek Godlewski, Polish Academy of Sciences, Poland) 50th Anniversary of the laser diode (Guest Editors: Mike Adams, Univeristy of Essex, UK and Stephane Calvez, University of Strathclyde, UK) In addition to the traditional topics of SST, I as Editor-in-chief, strongly support and welcome the submission of manuscripts on organic semiconductors, topological insulators, semiconductor nanostructures for photovoltaic, solid-state lighting and energy harvesting, IC application beyond Moore's law and fundamental works on semiconductors based on abundant materials. I am extremely optimistic about the future of SST. I believe that we will raise the standards of acceptance while maintaining the short time from submission to

  11. Foreword

    International Nuclear Information System (INIS)

    Sujkowski, Z.

    2001-01-01

    in the ''knee region'' (10 15 - 10 17 ) eV from the cosmic showers (the KASCADE collaboration) or inquire the Nature about the possible correlation of some cosmic radiation with the solar activity. One front-line in the low energy nuclear physics nowadays is the quest for the heaviest nuclear species - one of the specialities of our theory group. This group is known for its close contacts with experimentalists around the world. Recently, they highlighted these contacts by suggesting a new method to improve the mass determination for heavy nuclides from the Schottky noise signals in a storage ring. We move on to the plasma physics. The physics of the fourth state of matter, dominating in the Universe, the physics of non-linear phenomena, the physics of the XXI century. The physics closely linked to nuclear sciences and yet distinctly different. The physics which has numerous technological spin-offs, be it because of the experimental techniques it develops or of the phenomena it discovers. It is good to see that we are strongly entrenched in this field and have justified appetites for more. We focus now on the materials science done with nuclear techniques. We are pleased to note that our implantation techniques develop well and are now applied to e.g. hardening the steel edges. And we brag a bit about our latest work on the new crystallographic forms of uranium compounds after having done experiments we now propose explanations. The experimental physicist needs detectors. Ever better, bigger, more sophisticated. We have a strong group pursuing this improvement task, especially with respect to the scintillators. It was rewarding to learn that the international community has appreciated this effort. The appreciation came from the IEEE/Nuclear and Plasma Science Society with the award of their prestigious prize ''to Marek Moszynski for outstanding contributions to the modern scintillation detector and its application in physics experiment, nuclear medicine and other

  12. Executive Summary - Overview

    International Nuclear Information System (INIS)

    2005-01-01

    Professor Andrzej Budzanowski was Director of IFJ in the years 1990-2004. On September 1st 2004, on IFJ joining the Polish Academy of Sciences, Professor Marek Jezabek has been nominated by the President of PAN as the Director of IFJ, for a 4-year term. Our Institute, with a personnel of 450 (182 research staff) and over 50 Ph.D. students, is presently one of the largest institutes of the Polish Academy of Sciences and one of the largest research institutes in Poland. The scientific staff consists on 120 post-doctoral researchers, 26 Associated Professors and 36 State-Nominated Professors. The total budget of the Institute for the year 2004 was about 56 million Euro. The IFJ is financed mainly from the state budget of the Ministry of Scientific Research and Information Technology. In 2004 this financing was about 4 million Euro, constituting 72% of the Institute's total budget. The remaining part of our 2004 budget came from individual research projects, also sponsored by the Ministry of Scientific Research (688 kEuro), from international projects (368 kEuro) and from the Institute's entrepreneurship activities (498 kEuro). Between 2003 and 2004 we doubled our income from international projects. For further budget information. The Scientific Council of the Institute, which consists of 40 elected members of the Institute's staff and 4 external members (elected representatives from other Polish institutes and universities), is authorized to confer Ph.D. degrees in Physics and related disciplines, and to initiate and conduct habilitation and professorship procedures. In 2003-2004 17 Ph.D. theses and 11 habilitations have been completed. Following their review procedures, 3 Associate Professors at the IFJ became state-nominated Professors, receiving their nominations from Poland's President, Mr. A. Kwasniewski. The Institute is structured into 17 scientific departments which cover the range of our scientific interests. A summary of our main scientific achievements in

  13. PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

    Science.gov (United States)

    Grössing, Gerhard

    2012-05-01

    -statement: 'What is proved by impossibility proofs is lack of imagination.' In this sense, therefore, our task is to make use of the variety of the different approaches offered, for it is in scrutinizing each of them that a chance for further progress and understanding may emerge. The papers collected in these proceedings essentially follow the order of the plenary talks during the conference program, with the addition of the poster presentations. Prior to the contributions to EmerQuM11, the very first paper of these proceedings presents the opening lecture by Yves Couder who addressed both twin conferences with his talk on wave-particle duality in a classical system. (Although he was not able to participate personally, the contribution of Robert Carroll, a member of the academic advisory board, is included here. Regrettably, the lectures by John Bush, Marek Czachor, Mark Everitt, Felix Finster, and Lee Smolin could not be included, partly for copyright reasons.) Finally, I would like to thank Sarah Toms and Graham Douglas and their team at IOP Publishing (Bristol) for their friendly advice and help during the preparation of these proceedings. Vienna, April 2012 Gerhard Grössing

  14. Foreword

    International Nuclear Information System (INIS)

    Wrochna, G.

    2010-01-01

    -XFEL). The Polish parliament ratified the XFEL convention and IPJ was nominated to represent Poland as the E-XFEL GmbH shareholder. Most of the 21 mln EUR of the Polish contribution will be provided in-kind. This includes elements of the accelerator delivered by our institute. IPJ was also granted over 4 mln EUR to provide Neutral Beam Injection elements for the stellarator (thermonuclear reactor) W7-X being built in Greifswald, Germany. Our experts are participating in the design of the European Spallation Source in Lund, Sweden. We are also considering contributions to other large research projects in Europe, especially those from the ESFRI roadmap. Development of new technologies resulted in 2010 in a few patent proposals. A method of surface modification by ion beams to make better forms for the production of rubber elements was given an award at international exhibition ITEX in Kuala Lumpur. It was a joint development with the Institute of Electronic Materials Technology (ITME) in Warsaw and the Institute for Engineering of Polymer Materials and Dyes (IMPiB) in Torun. Another award was given at the International Exhibition of Innovations in Warsaw to IPJ and the Techtra company for a new detector for non-destructive industrial radiography. An important element of the mission of our institute is to share the excitement of front-line research with the general public. It is not easy, however, for scientists to meet the demands of the media to present in just a few sentences the essence of a sophisticated theory or an advanced technology. This changed when dr Marek Pawlowski was appointed the IPJ Spokesman. Journalists appreciated his role in bridging the gap between scientists and the media and granted him a special award in the '' Science Popularizer of the Year 2010 '' contest. In the perspective of implementing nuclear power in Poland, society requires quite detailed information on this subject, given in an understandable way. This is the mission of our Department of

  15. PREFACE: Quantum dots as probes in biology

    Science.gov (United States)

    Cieplak, Marek

    2013-05-01

    photosynthetic systems. The next paper, by Olejnik et al, discussed metallic QDs which enhance photosynthetic function in light-harvesting biomolecular complexes. Such hybrid structures with gold QDs are shown to exhibit a strong increase in the fluorescence quantum yield. The next two papers, by Sikora et al and Kaminska et al deal with the ZnO nanoparticles passivated by MgO. In the first of these two papers, the authors describe the behavior of ZnO/MgO when introduced to human cancer cells. In the second, the authors describe the QDs with an extra outer layer of Fe2O3 which makes the nanoparticles superparamagnetic and also capable of generation of reactive oxygen species which could be applied to form localized centers of toxicity for cancer treatment. Finally, in the last paper by Yatsunenko et al, the authors discuss several semiconducting QDs like ZnO with various rare-earth dopands. They propose a microwave-driven hydrothermal technology to make them, characterize their luminescence and demonstrate their usefulness in the early recognition of cancer tissues. Quantum dots as probes in biology contents Quantum dots as probes in biologyMarek Cieplak Luminescent nanoparticles and their applications in the life sciencesVarun K A Sreenivasan, Andrei V Zvyagin and Ewa M Goldys Ferredoxin:NADP+ oxidoreductase in junction with CdSe/ZnS quantum dots: characteristics of an enzymatically active nanohybrid Krzysztof Szczepaniak, Remigiusz Worch and Joanna Grzyb Spectroscopic studies of plasmon coupling between photosynthetic complexes and metallic quantum dotsMaria Olejnik, Bartosz Krajnik, Dorota Kowalska, Guanhua Lin and Sebastian Mackowski Luminescence of colloidal ZnO nanoparticles synthesized in alcohols and biological application of ZnO passivated by MgOBożena Sikora, Krzysztof Fronc, Izabela Kamińska, Kamil Koper, Piotr Stępień and Danek Elbaum Novel ZnO/MgO/Fe2O3 composite optomagnetic nanoparticles I Kamińska, B Sikora, K Fronc, P Dziawa, K Sobczak, R Minikayev, W

  16. Editorial

    Directory of Open Access Journals (Sweden)

    Dana Kapitulčinová

    2013-12-01

    Sciences, Philosophy, and Theology (Reviewed Paper by Zuzana Svobodová. This philosophical text analyses the work of Josef Petr Ondok – Czech theologian, philosopher and biologist – from the perspective of ethics and ecoethics. 4 The Purpose of Education: Australian and Slovenian perspectives in Education for Sustainability (Inspiration by Phil Smith and Majda Naji. The authors present their view on the purpose of education in the context of sustainable development and include examples of education for sustainable development from their countries – Slovenia and Australia. 5 Environmental mining limits in the North Bohemian Lignite Region. Book review: Říha, M., Stoklasa, J., Lafarová, M., Dejmal, I., Marek, J., Pakosta, P., Beránek, K. Environmental mining limits in the North Bohemian Lignite Region. Společnost pro krajinu, Praha 2005. Translation: Petr Kurfürst. This book review written by Andrew Barton looks at the issue of mining limits in the region of North-West Bohemia in the Czech Republic and briefly summarises from the content of the book originally published in 2005 (in Czech, but later translated into English supplemented with the most up-to-date information on the current situation. 6 Informational texts: A very interesting article on environmental literacy by Petr Daniš, originally published as a reviewed article in Czech (Envigogika 3/2013, has been translated into English and is now available to our readers. School teachers might be interested in the announcement of a school essay competition run by The Living Rainforest, a UK-based charity. 7 Related announcements: As we feel that dialogue on environmental education and ESD related issues in CZ should be promoted nationally and internationally, this time we are publishing two issues simultaneously (for the content of the Czech issue of Envigogika, see here. We wish you inspirational reading and a peaceful Christmas holiday, as well as a successful New Year. The Envigogika editorial team In

  17. „To nie była Ameryka”. Z Michaelem Charlesem Steinlaufem rozmawia Elżbieta Janicka (Warszawa – Nowy Jork – Warszawa, 2014–2015

    Directory of Open Access Journals (Sweden)

    Elżbieta Janicka

    2016-01-01

    Full Text Available “This was not America.” Michael Charles Steinlauf in conversation with Elżbieta Janicka (Warsaw – New York – Warsaw, 2014–2015 Born in Paris in 1947, Michael Charles Steinlauf talks about his childhood in New York City, in the south of Brooklyn (Brighton Beach, in a milieu of Polish Jewish Holocaust survivors. His later experiences were largely associated with American counterculture, the New Left, an anti-war and antiracist student movement of the 1960s (Students for a Democratic Society, SDS as well as the anticapitalist underground of the 1970s (“Sunfighter”, “No Separate Peace”. In the 1980s, having undertaken Judaic Studies at Brandeis University, Steinlauf arrived in Poland, where he became part of the democratic opposition circles centred around the Jewish Flying University (Żydowski Uniwersytet Latający, ŻUL. In the independent Third Republic of Poland, he contributed to the creation of the Museum of the History of Polish Jews in Warsaw. Michael C. Steinlauf’s research interests focus on the work of Mark Arnshteyn (Andrzej Marek and of Yitskhok Leybush Peretz, Yiddish theatre as well as Polish narratives of the Holocaust. The latter were the subject of his monograph Bondage to the dead: Poland and the memory of the Holocaust (1997, Polish edition 2001 as Pamięć nieprzyswojona. Polska pamięć Zagłady. An important topic of the conversation is the dispute concerning the categories used to describe the Holocaust, including the conceptualisation of Polish majority experience of the Holocaust as a collective trauma. Controversies also arise in connection with the contemporary phenomena popularly conceptualised as the “revival of Jewish culture in Poland” and “Polish–Jewish dialogue.”  Another subject of the conversation is Michał Sztajnlauf (1940–1942, Michael C. Steinlauf’s stepbrother. The fate of the brothers was introduced into the canon of Polish culture by Hanna Krall’s short story Dybuk

  18. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    -allergic humans Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Martin Danzer, Christian Gabriel, Theresa Thalhamer, Sandra Scheiblhofer, Josef Thalhamer, Richard Weiss P4 Analyzing the cross-reactivity profile of the major ragweed allergen Amb a 1 Martin Wolf, Michael Hauser, Ulrike Pichler, Teresa Twaroch, Gabriele Gadermaier, Christof Ebner, Hidenori Yokoi, Toshiro Takai, Alain Didierlaurent, Adriano Mari, Peter Briza, Heidrun Behrendt, Angela Neubauer, Frank Stolz, Fátima Ferreira, Michael Wallner P5 LTP (Pru p 3 sensitisation in skin prick test: which means in clinical practice? Sara Carvalho, Tatiana Lourenço, Joana Cosme, Fátima Cabral Duarte, Amélia Spínola Santos, Ana Célia Costa, Manuel Pereira Barbosa P6 IgE profiles, allergen exposure and lifestyle of 501 Austrian pupils: investigation of influences on the development of allergic sensitizations Teresa Stemeseder, Eva Klinglmayr, Bettina Schweidler, Lisa Lueftenegger, Stephanie Moser, Patrick Doppler, Roland Lang, Martin Himly, Gertie J. Oostingh, Arne Bathke, Joerg Zumbach, Thomas Hawranek, Gabriele Gadermaier P7 Molecular profiles of sensitization to perennial inhalant allergens in a middle European region Petr Panzner, Martina Vachova, Tomas Vlas, Marek Maly P8 Evolution of the IgE response to house dust mite allergen molecules in childhood Daniela Posa, Serena Perna, Stephanie Hofmaier, Laura Hatzler, Alexander Rohrbach, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Philippe Stock, Ulrich Wahn, Linus Grabenhenrich, Thomas Keil, Susanne Lau, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi P9 Tropomyosin (Pen a1: to include or not to include in skin prick testing? Joana Cosme, Sara Carvalho, Tatiana Lourenço, Amélia Spínola Santos, Manuel Pereira Barbosa Immunoallergy Department - Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal, Lisbon, Portugal; Immunoallergy Department - Hospital de Santa Maria

  19. Úvodník 2012/VII/1

    Directory of Open Access Journals (Sweden)

    Jana Dlouhá

    2012-05-01

    í?, musíme se o to pokusit sami a příznivá zpráva je, že můžeme být slyšet. Takže poslouchejte – nejen o Riu, třebaže se zde o něm píše a dokonce i tak docela aktivisticky cosi požaduje po vládcích našich. Především jsme tentokrát získali (a opečovali několik pozoruhodných textů recenzovaných: Marek Franěk diskutuje český překlad škály, která má testovat emocionální, kognitivní a zážitkové měřící spojení s přírodou – v anglosaském světě známe jako Nature Relatedness Scale, jejíž využití v našich kulturních podmínkách má své meze. Jan Činčera zkoumá, jak žáci čtvrtých tříd vnímají les, interpretují jeho systémovou podstatu a posuzují vlivy člověka na něj; používá při tom techniku mentálního mapování. Optimální podobu environmentální výchovy v předškolním vzdělávání hledají autorky Kateřina Jančaříková a Magdalena Kapuciánová – analyzují nedostatečnou pozornost věnovanou environmentální výchově v předškolním věku a navrhují, jak se s tím vypořádat: součástí textu je metodika poskytující učitelkám MŠ kritéria realizace a autoevaluace environmentální výchovy na této úrovni. Globální změně klimatu se věnuje Barbora Duží – uvádí možnosti didaktického zpracování tématu na úrovni středních škol a nabízí nástroj pro hodnocení různorodých informačních zdrojů pro potřeby výuky. Viera Chrenščová popisuje, do jaké míry jsou na slovenských základných školách využívané exkurze, a rozebírá názory učitelů na tuto organizační formu výuky. V části Envigogiky, která by nás měla spíše inspirovat, najdeme opravdu vydatný text Martina Říhy – podrobně v něm rozebírá, jakou by chtěl mít svou zemi - Českou republiku, a to ve všech oblastech hospodářství, politiky... Nové cíle a indikátory pro environmentální vzdělávání, výchovu a osvětu v České republice

  20. Selective mobility, segregation and neighbourhood effects

    Directory of Open Access Journals (Sweden)

    Sanne Boschman

    2015-11-01

    and interethnic contact in the Netherlands  In Chapters 2 to 5 I study selective residential mobility and neighbourhood choice, while in Chapter 6 I study presumed neighbourhood effects mechanisms. According to the neighbourhood effects literature, one of the mechanisms through which neighbourhood effects transpire is via social interactions with neighbours (Ellen and Turner, 1997; Erbring and Young, 1979; Galster, 2012. Social interactions with natives provide ethnic minorities with the opportunity to learn the majority language, standards and values (Lazear, 1999, and with access to valuable information not present within the own ethnic network. Living in ethnic minority concentration neighbourhoods might reduce the opportunities for ethnic minorities to interact with natives and thereby hamper their integration and there life chances. Policymakers in many European countries therefore perceive concentrations of ethnic minorities as undesirable and try to create more mixed neighbourhoods (Bolt, 2009. It is, however, unclear to what extent the population composition of the residential neighbourhood determines social interactions, as people are found to increasingly have social contacts over larger areas (Boomkens, 2006. Therefore, in Chapter 6 I test whether the ethnic composition of the residential neighbourhood affects interethnic contact.  I estimate a multilevel binary logistic regression model explaining whether or not ethnic minorities have contact with native Dutch people. This regression model includes both personal characteristics and neighbourhood characteristics including the share of native Dutch people in the neighbourhood. In earlier research (Gijsberts and Dagevos, 2005; Van der Laan Bouma-Doff, 2007 ethnic minorities have been found to have less contact with natives if the share of natives in the neighbourhood is lower, however, I find no effect of the neighbourhood ethnic composition on interethnic contact. Whether ethnic minorities have contact