WorldWideScience

Sample records for tissue procurement system

  1. Procurement Tracking System (PTS)

    Data.gov (United States)

    Office of Personnel Management — The Procurement Tracking System (PTS) is used solely by the procurement staff of the Office of the Inspector General (OIG) at the U.S. Office of Personnel Management...

  2. Designing flexible procurement systems

    OpenAIRE

    Hughes, Will

    1990-01-01

    The systems used for the procurement of buildings are organizational systems. They involve people in a series of strategic decisions, and a pattern of roles, responsibilities and relationships that combine to form the organizational structure of the project. To ensure effectiveness of the building team, this organizational structure needs to be contingent upon the environment within which the construction project takes place. In addition, a changing environment means that the organizational s...

  3. Indonesia - Country Procurement Assessment Report : Reforming the Public Procurement System

    OpenAIRE

    World Bank

    2001-01-01

    The main objectives of the Country Procurement Assessment Review (CPAR) are to diagnose the public procurement system in Indonesia, assess actual compliance with the country's procurement laws and regulations on the ground, and identify reforms to improve the existing system in line with internationally accepted principles. Section 1 gives an overview. Section 2 describes Indonesia's exist...

  4. PROMIS (Procurement Management Information System)

    Science.gov (United States)

    1987-01-01

    The PROcurement Management Information System (PROMIS) provides both detailed and summary level information on all procurement actions performed within NASA's procurement offices at Marshall Space Flight Center (MSFC). It provides not only on-line access, but also schedules procurement actions, monitors their progress, and updates Forecast Award Dates. Except for a few computational routines coded in FORTRAN, the majority of the systems is coded in a high level language called NATURAL. A relational Data Base Management System called ADABAS is utilized. Certain fields, called descriptors, are set up on each file to allow the selection of records based on a specified value or range of values. The use of like descriptors on different files serves as the link between the falls, thus producing a relational data base. Twenty related files are currently being maintained on PROMIS.

  5. Integrated Procurement Management System, Version II

    Science.gov (United States)

    Collier, L. J.

    1985-01-01

    Integrated Procurement Management System, Version II (IPMS II) is online/ batch system for collecting developing, managing and disseminating procurementrelated data at NASA Johnson Space Center. Portions of IPMS II adaptable to other procurement situations.

  6. PUBLIC PROCUREMENT SYSTEM IN RUSSIA

    Directory of Open Access Journals (Sweden)

    Alla V. Trofimovskaya

    2013-01-01

    Full Text Available This article contains information on the theoretical-methodological research of the Institute of public procurement. The focus is on the consideration of the implementation of the priority tasks for the state contract system and the role in their solving that regional level of management can play. Opportunities in the sphere of state regulation, that Moscow, as the subject of the Federation, has, are educed in the article. The problem of transformation the existing contractual mechanisms for the formation of the model of public contract system, is studied.

  7. Information Technology Procurement Authorization (ITPA) Tracking System

    Data.gov (United States)

    Office of Personnel Management — Information Technology Procurement Authorization (ITPA) Tracking System is used for gathering consistent data from U.S. Office of Personnel Management (OPM) program...

  8. Federal Procurement Data System - FPDS API

    Data.gov (United States)

    General Services Administration — The Federal Procurement Data System (FPDS) Next Generation has been re-engineered as a real-time federal enterprise information system. Web services based on SOAP...

  9. Standard Procurement System Use and User Satisfaction

    National Research Council Canada - National Science Library

    2001-01-01

    The audit was performed in response to concerns expressed by the Chairman, House of Representatives Committee on Budget that DoD was not effectively spending Federal funds to acquire the Standard Procurement System (SPS...

  10. The Malaysian Public Procurement's Prevalent System and its Weaknesses

    OpenAIRE

    Rohana Othman; Husein Zakaria; Norlaili Nordin; Zamzam Shahidan; Kamaruzaman Jusoff

    2010-01-01

    Problem statement: This study examined the public procurement system as prevalent in the Malaysian government system of administration. Various aspects of public procurement are outlined including types and the processes that entail public procurement. This study also highlighted the weaknesses in the manual public procurement processes that are opened to potential abuse and mismanagement resulting in corruption. This study places the Malaysian Government public procurement system under the s...

  11. Mexico - The Federal Procurement System : Challenges and Opportunities

    OpenAIRE

    World Bank

    2007-01-01

    The World Bank carried out the first country procurement assessment review (CPAR) jointly with the Government in 2001, focusing on the features and performance of the federal procurement system. Based on the action plan included in the 2001 CPAR, the government reformed federal procurement laws and regulations in 2005 and furthered the development of Government Procurement Electronic Syste...

  12. Transformation of fraud activities in procurement system in Indonesia

    Science.gov (United States)

    Setiani, N.; Huda, S. N.; Pulungan, R.; Winarko, E.

    2017-03-01

    E-procurement has been applied in Indonesia since 2008 through the adoption of Electronic Procurement System (SPSE). The purpose of the use of SPSE in the procurement process is to improve the efficiency of goods or services procurement. In the bidding process, intensive communication and data exchange between providers and organizers are urgently needed. Through SPSE, the frequency of face to face meetings between providers and the committee can be reduced. This is expected to minimize potential fraud behaviors in the goods or services procurement conducted through the tender process. There exists a transformation of activities in the procurement through SPSE from the tender process that was previously done manually. In this paper, we analyze this transformation between manual procurement process and SPSE-based procurement process. The result of the analysis is exploited for investigating the possibility of fraud behavior transformations in every phase of e-procurement activities.

  13. A portrait of tissue phosphoprotein stability in the clinical tissue procurement process.

    Science.gov (United States)

    Espina, Virginia; Edmiston, Kirsten H; Heiby, Michael; Pierobon, Mariaelena; Sciro, Manuela; Merritt, Barbara; Banks, Stacey; Deng, Jianghong; VanMeter, Amy J; Geho, David H; Pastore, Lucia; Sennesh, Joel; Petricoin, Emanuel F; Liotta, Lance A

    2008-10-01

    Little is known about the preanalytical fluctuations of phosphoproteins during tissue procurement for molecular profiling. This information is crucial to establish guidelines for the reliable measurement of these analytes. To develop phosphoprotein profiles of tissue subjected to the trauma of excision, we measured the fidelity of 53 signal pathway phosphoproteins over time in tissue specimens procured in a community clinical practice. This information provides strategies for potential surrogate markers of stability and the design of phosphoprotein preservative/fixation solutions. Eleven different specimen collection time course experiments revealed augmentation (+/-20% from the time 0 sample) of signal pathway phosphoprotein levels as well as decreases over time independent of tissue type, post-translational modification, and protein subcellular location (tissues included breast, colon, lung, ovary, and uterus (endometrium/myometrium) and metastatic melanoma). Comparison across tissue specimens showed an >20% decrease of protein kinase B (AKT) Ser-473 (p 20% increases within 90-min postprocurement. Endothelial nitric-oxide synthase Ser-1177 did not change over the time period evaluated with breast or leiomyoma tissue. Treatment with phosphatase or kinase inhibitors alone revealed that tissue kinase pathways are active ex vivo. Combinations of kinase and phosphatase inhibitors appeared to stabilize proteins that exhibited increases in the presence of phosphatase inhibitors alone (ATF-2 Thr-71, SAPK/JNK Thr-183/Tyr-185, STAT1 Tyr-701, JAK1 Tyr-1022/1023, and PAK1/PAK2 Ser-199/204/192/197). This time course study 1) establishes the dynamic nature of specific phosphoproteins in excised tissue, 2) demonstrates augmented phosphorylation in the presence of phosphatase inhibitors, 3) shows that kinase inhibitors block the upsurge in phosphorylation of phosphoproteins, 4) provides a rational strategy for room temperature preservation of proteins, and 5) constitutes a

  14. Economic risks of the system of state and municipal procurement

    Directory of Open Access Journals (Sweden)

    Belokrylova Olga, S.

    2015-12-01

    Full Text Available In the paper the audit of economic risks at all stages of procurement for state and municipal needs from both customers and bidders is carried out on the basis of the implementation of the integrated approach . Stages in the procurement under a single contract system, which is characterized by the high economic risks are planning, supplier selection, conclusion and execution of the contract. A number of the measures according to the localization of economic risks are offered, in particular the implementation of compliance programs, which institutionalize the compliance by the organization, anti-corruption legislation; increasing qualification of specialists in public procurement and increased control through centralization of procurement.

  15. Strengthening Procurement Systems in Latin America and the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... and the development of MSMEs and electronic commerce. Information and Communication Technologies (ICTs) are key to modernizing public administration systems in general and public procurement in particular. In 2002, national government procurement bodies established the Inter-American Network for Government ...

  16. SUITABILITY OF CORNEAL TISSUE FOR TRANSPLANTATION PROCURED FROM HANGING CASES

    Directory of Open Access Journals (Sweden)

    Rekha Gyanchand

    2017-06-01

    Full Text Available BACKGROUND Requirement of donor cornea is essential to target the corneal blind. The best method to procure such corneas is from any major hospitals, which has a mortuary facility. The eye donation with hanging as the cause of death is very common in a mortuary setup. Some factors that are concerning regarding corneas procured from death due to hanging is the prolonged exposure of the cornea at the time of death, the exact time of death is not known, most of the cadavers are refrigerated for investigations as these arrive at the mortuary usually at night. Due to these reasons, the corneal surgeons are hesitant to use corneas procured from death due to hanging for corneal transplantation. Analysing these corneas would contribute to a great extent to the donor cornea pool in providing sight to the corneal blind, especially as majority are young individuals who commit suicide by hanging. In this study, the donor corneas were analysed with regards to corneal epithelial defect, endothelial cell morphology and utilisation of these corneas for transplantation. The aim of the HCRP study is to analyse the effect of death due to hanging on donor cornea. 1. Corneal epithelial status. 2. Corneal endothelial cell morphology. 3. Utilisation of corneas for transplantation. MATERIALS AND METHODS Donor corneas from 22 donors who died due to hanging were procured from hospital mortuary. All the 44 corneas were transplanted. Various parameters like demography, death to enucleation time, cadaver preservation in cold storage, endothelial cell density and utilisation of cornea for transplantation were noted. Design- Retrospective study. Statistical Analysis- Descriptive statistics, Pearson and Spearman correlation and Chi-square test were used to test the hypotheses. RESULTS Out of the 44 corneas analysed, 75% of the donors were refrigerated as a part of medicolegal investigations protocol. The average DTP time was 12 hours in refrigerated group and 5 hours in non

  17. Corruption and innovation in the Albanian public procurement system

    Directory of Open Access Journals (Sweden)

    Reida Kashta

    2014-07-01

    The question marks that this paper raises are: what are the means used in the war against corruption in the public procurement field in Albania? Did they had any real impact or they just reshaped the ways of doing corruption? The main finding of this paper is that introduction of e-procurement system was one of the most appropriate means to fight corruption in Albania, because this system fixed one of the biggest problems of the Albanian Public Procurement system; lack of transparency. The electronic system is transparent, since it provides the increasing of information passing through it, and the most important, it enhances the responsibility in relations between the contracting authorities and economic operators, enabling a more effective and efficient use of the tax payers’ money.

  18. Assignment Procedures in the Air Force Procurement Management Information System.

    Science.gov (United States)

    Ward, Joe H., Jr.; And Others

    An overview is presented of the procedure for offering jobs in the Air Force Procurement Management Information System (PROMIS), an assignment system which makes possible the use of human resources research findings to improve individual personnel assignments. A general framework for viewing personnel assignment systems is presented; then job…

  19. Procurement performance measurement system in the health care industry.

    Science.gov (United States)

    Kumar, Arun; Ozdamar, Linet; Ng, Chai Peng

    2005-01-01

    The rising operating cost of providing healthcare is of concern to health care providers. As such, measurement of procurement performance will enable competitive advantage and provide a framework for continuous improvement. The objective of this paper is to develop a procurement performance measurement system. The paper reviews the existing literature in procurement performance measurement to identify the key areas of purchasing performance. By studying the three components in the supply chain collectively with the resources, procedures and output, a model is been developed. Additionally, a balanced scorecard is proposed by establishing a set of generic measures and six perspectives. A case study conducted at the Singapore Hospital applies the conceptual model to describe the purchasing department and the activities within and outside the department. The results indicate that the material management department has already made a good start in measuring the procurement process through the implementation of the balanced scorecard. There are many data that are collected but not properly collated and utilized. Areas lacking measurement include cycle time of delivery, order processing time, effectiveness, efficiency and reliability. Though a lot of hard work was involved, the advantages of establishing a measurement system outweigh the costs and efforts involved in its implementation. Results of balanced scorecard measurements provide decision-makers with critical information on efficiency and effectiveness of the purchasing department's work. The measurement model developed could be used for any hospital procurement system.

  20. Automated Procurement System (APS) revised project management plan (DS-03)

    Science.gov (United States)

    Murphy, Diane R.

    1995-01-01

    The Project Plan is the governing document for the implementation of the Automated Procurement System (APS). It includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  1. Profile of effective donors from organ and tissue procurement services

    Science.gov (United States)

    Rodrigues, Simey de Lima Lopes; Ferraz Neto, Jose Ben-Hur de Escobar; Sardinha, Luiz Antonio da Costa; Araujo, Sebastião; Zambelli, Helder Jose Lessa; Boin, Ilka de Fátima Santana Ferreira; Athayde, Maria Valeria de Omena; Montone, Eliete Bombarda Bachega; Panunto, Marcia Raquel

    2014-01-01

    Objective To characterize the profile of effective organ and tissue donors and to understand which organs and tissues were donated for transplantation. Methods This was a quantitative, descriptive, exploratory, retrospective study that analyzed clinical data from 305 donors between January 2006 to December 2010. The data were then analyzed using descriptive analyses, generating frequency tables, measures of position (mean, minimum and maximum) and measures of dispersion (standard deviation) for data that was social and clinical in nature. Results There was an overall predominance of white (72%) and male (55%) individuals between the ages of 41 and 60 years (44%). The primary cause of brain death was cerebrovascular accident (55%). In the patient history, 31% of the patients were classified as overweight, 27% as hypertensive and only 4.3% as having diabetes mellitus. Vasoactive drugs were used in 92.7% of the donors, and the main drug of choice was noradrenaline (81.6%). Hyperglycemia and hypernatremia were diagnosed in 78% and 71% of the donors, respectively. Conclusion Significant hemodynamic changes were found, and the results indicate that the use of vasoactive drugs was the main strategy used to control these changes. Furthermore, most donors presented with hyperglycemia and hypernatremia, which were frequently reported in association with brain death. The persistent nature of these findings suggests that the organ donors were inadequately maintained. PMID:24770685

  2. Pitfalls of improperly procured adjacent non-neoplastic tissue for somatic mutation analysis using next-generation sequencing

    Directory of Open Access Journals (Sweden)

    Lei Wei

    2016-10-01

    Full Text Available Abstract Background The rapid adoption of next-generation sequencing provides an efficient system for detecting somatic alterations in neoplasms. The detection of such alterations requires a matched non-neoplastic sample for adequate filtering of non-somatic events such as germline polymorphisms. Non-neoplastic tissue adjacent to the excised neoplasm is often used for this purpose as it is simultaneously collected and generally contains the same tissue type as the neoplasm. Following NGS analysis, we and others have frequently observed low-level somatic mutations in these non-neoplastic tissues, which may impose additional challenges to somatic mutation detection as it complicates germline variant filtering. Methods We hypothesized that the low-level somatic mutation observed in non-neoplastic tissues may be entirely or partially caused by inadvertent contamination by neoplastic cells during the surgical pathology gross assessment or tissue procurement process. To test this hypothesis, we applied a systematic protocol designed to collect multiple grossly non-neoplastic tissues using different methods surrounding each single neoplasm. The procedure was applied in two breast cancer lumpectomy specimens. In each case, all samples were first sequenced by whole-exome sequencing to identify somatic mutations in the neoplasm and determine their presence in the adjacent non-neoplastic tissues. We then generated ultra-deep coverage using targeted sequencing to assess the levels of contamination in non-neoplastic tissue samples collected under different conditions. Results Contamination levels in non-neoplastic tissues ranged up to 3.5 and 20.9 % respectively in the two cases tested, with consistent pattern correlated with the manner of grossing and procurement. By carefully controlling the conditions of various steps during this process, we were able to eliminate any detectable contamination in both patients. Conclusion The results demonstrated that the

  3. 40 CFR 35.6550 - Procurement system standards.

    Science.gov (United States)

    2010-07-01

    ... referred to the local, State, Tribal, or Federal authority having proper jurisdiction. (5) Selection... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Procurement system standards. 35.6550... ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund...

  4. 'Procurement quality engineering': A measurement driven system to assure quality at each step in the procurement process

    International Nuclear Information System (INIS)

    Rinderman, R.R.

    1993-01-01

    The 'Procurement Quality Function' is an element of the Body of Knowledge of Quality Engineering, as defined by the American Society for Quality Control (ASQC). This paper describes the Procurement Quality function which has been installed as an integral part of the Quality Engineering group of the Technical and Management Support Services (T ampersand MSS) contractor to the United States Department of Energy (DOE) Yucca Mountain Site Characterization Project. Each of the elements of the T ampersand MSS Procurement Quality Engineering (PQE) system is discussed along with the measurements obtained. With the installation and development of the PQE system we have attained more meaningful evaluation of supplier capability, reduction of procurement document review reject ratios from 31% to less than 2% per quarter, more effective measurement and control of supplier performance, and the ability to enter into a meaningful teaming effort with T ampersand MSS suppliers

  5. Federal Procurement Data System - FAADS API

    Data.gov (United States)

    General Services Administration — The Federal Award Assistance Data System (FAADS) has been re-engineered as a real-time federal enterprise information system. Web services based on SOAP and XML,...

  6. Audit the effectiveness of the electronic system of public (state) procurement

    OpenAIRE

    Pysmenna, М.

    2017-01-01

    The study deals with the methodology of the audit the effectiveness of e-environment for public procurement. The purpose of this paper is deepening theoretical and methodological framework for auditing electronic systems for public (government) procurement. Research methods included analysis of legislation in the area of procurement, monitoring of individual transactions of public (state) procurement, interview with the responsible persons of budgetary funds on the assessment of the effective...

  7. 48 CFR 504.602-71 - Federal Procurement Data System-Public access to data.

    Science.gov (United States)

    2010-10-01

    ... Government procurement to the public. (b) Fee for direct hook-up. To the extent that a member of the public... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Federal Procurement Data... Procurement Data System—Public access to data. (a) The FPDS database. The General Services Administration...

  8. Review: The procurement, storage and quality assurance of frozen blood and tissue biospecimens

    Directory of Open Access Journals (Sweden)

    Manoj S. Charde

    2014-05-01

    Full Text Available The preserved frozen biospecimens are ideal for evaluating the genome, transcriptome, and proteome. Here we present a current overview of experimental data regarding procurement, storage, and quality assurance that can informthe handling of frozen biospecimens. Degradation of frozen biospecimens can be affected by collecting methodology, premortem agonal changes and warm ischemic time during surgery.  Tissue storage at− 80 °C can preserve DNA and protein but RNA show degradation at 5 years, therefore storage at − 150 °C provides significant advantages.  Histologic quality assurance of tissue biospecimens is typically performed at the time of surgery but should also be conducted on the aliquot to be distributed because of tissue heterogeneity.Additional qualityassurance testing should be dictated by the anticipated downstream applications.

  9. Administrative law risks of the governmental and municipal procurement system

    Directory of Open Access Journals (Sweden)

    Dyuzhikov Sergey, A.

    2015-09-01

    Full Text Available The paper deals with the administrative law risks of the Russian system of public procurement. The authors analyze the foregoing risks in the view of the correlation of risk situations, risk actions (omission and administrative law prohibitions. The authors are considering problems of the subject and some other characteristics essential to the administrative offenses in terms of the most systemic risk in this sphere – an information risk. The materials on law practice open to general use generated in more than 25 entities of the Russian Federation were used in the paper while preparing.

  10. Alarm systems a guide to design, management and procurement

    CERN Document Server

    Engineering Equipment and Materials Users' Association. London

    2013-01-01

    Alarm systems form an essential part of the operator interfaces to large modern industrial facilities. They provide vital support to the operators by warning them of situations that need their attention and have an important role in preventing, controlling and mitigating the effects of abnormal situations. Since it was first published in 1999, EEMUA 191 has become the globally accepted and leading guide to good practice for all aspects of alarm systems. The guide, developed by users of alarm systems with input from the GB Health and Safety Executive, gives comprehensive guidance on designing, managing and procuring an effective alarm system. The new Third Edition has been comprehensively updated and includes guidance on implementing the alarm management philosophy in practice; applications in geographically distributed processes; and performance metrics and KPIs.

  11. Children as donors : a national study to assess procurement of organs and tissues in pediatric intensive care units

    NARCIS (Netherlands)

    Siebelink, Marion J.; Albers, Marcel J. I. J.; Roodbol, Petrie F.; Van de Wiel, Harry B. M.

    2012-01-01

    A shortage of size-matched organs and tissues is the key factor limiting transplantation in children. Empirical data on procurement from pediatric donors is sparse. This study investigated donor identification, parental consent, and effectuation rates, as well as adherence to the national protocol.

  12. The Investigation and Elimination of Public Procurement Fraud in Government Sectors (A Case Study in Indonesia’s Procurement System: Cases from 2006 to 2012)

    OpenAIRE

    Maulidi, Ach

    2017-01-01

    This paper offers insights to enhance our understanding of public procurement fraud through analyzing current 173 cases during 2006 to 2012 in Indonesia’s procurement system using various points of view. These insights are synthesized from current research findings and contemporary thinking elaborated by practical knowledge and skills, the aim of which is to produce accurate analysis. The main aim of this paper is to participate in terms of combating procurement fraud by suggesting plausible ...

  13. Level of satisfaction and issues with procurement systems used in the Malaysian public sector

    Directory of Open Access Journals (Sweden)

    Mastura Jaafar

    2013-03-01

    Full Text Available Since the declaration of Malaysian independence, the public sector has significantly contributed to the country’s development. In the 1990s, a new procurement system was developed due to CIBD various changes in the construction industry. Since that period, the poor quality of public sector projects has started to attract public attention. This paper describes a study that was conducted to identify the dominant public procurement systems in place, the problems associated with these systems, and the satisfaction level of the industry players in the Malaysian construction industry. The results were drawn from 84 survey responses and interviews with industry players. The public sector is using a traditional system inherited from the British, with an intention to adopt new procurement systems. Aside from the disputes that are present in most systems, the public sector seems to encounter particular problems in relation to capabilities, time, and cost of the major procurement systems used. Traditional work culture and the industry environment influence public sector practice, which accounts for the modifications of each procurement system used. Thus, the full advantages of using an alternative procurement system may not be realised in public sector organizations. This produces an average level of satisfaction gained from the procurement system adopted. As a developing country, Malaysia needs to exert significant efforts to improve the public procurement system

  14. Level of satisfaction and issues with procurement systems used in the Malaysian public sector

    Directory of Open Access Journals (Sweden)

    Mastura Jaafar

    2013-03-01

    Full Text Available Since the declaration of Malaysian independence, the public sector has significantly contributed to the country’s development. In the 1990s, a new procurement system was developed due to CIBD various changes in the construction industry. Since that period, the poor quality of public sector projects has started to attract public attention. This paper describes a study that was conducted to identify the dominant public procurement systems in place, the problems associated with these systems, and the satisfaction level of the industry players in the Malaysian construction industry. The results were drawn from 84 survey responses and interviews with industry players. The public sector is using a traditional system inherited from the British, with an intention to adopt new procurement systems. Aside from the disputes that are present in most systems, the public sector seems to encounter particular problems in relation to capabilities, time, and cost of the major procurement systems used. Traditional work culture and the industry environment influence public sector practice, which accounts for the modifications of each procurement system used. Thus, the full advantages of using an alternative procurement system may not be realised in public sector organizations. This produces an average level of satisfaction gained from the procurement system adopted. As a developing country, Malaysia needs to exert significant efforts to improve the public procurement system.

  15. Procurement of Human Tissues for Research Banking in the Surgical Pathology Laboratory: Prioritization Practices at Washington University Medical Center

    Science.gov (United States)

    Chernock, Rebecca D.; Leach, Tracey A.; Kahn, Ajaz A.; Yip, James H.; Rossi, Joan; Pfeifer, John D.

    2011-01-01

    Academic hospitals and medical schools with research tissue repositories often derive many of their internal human specimen acquisitions from their site's surgical pathology service. Typically, such acquisitions come from appropriately consented tissue discards sampled from surgical resections. Because the practice of surgical pathology has patient care as its primary mission, competing needs for tissue inevitably arise, with the requirement to preserve adequate tissue for clinical diagnosis being paramount. A set of best-practice gross pathology guidelines are summarized here, focused on the decision for tissue banking at the time specimens are macroscopically evaluated. These reflect our collective experience at Washington University School of Medicine, and are written from the point of view of our site biorepository. The involvement of trained pathology personnel in such procurements is very important. These guidelines reflect both good surgical pathology practice (including the pathologic features characteristic of various anatomic sites) and the typical objectives of research biorepositories. The guidelines should be helpful to tissue bank directors, and others charged with the procurement of tissues for general research purposes. We believe that appreciation of these principles will facilitate the partnership between surgical pathologists and biorepository directors, and promote both good patient care and strategic, value-added banking procurements. PMID:23386925

  16. Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality.

    Science.gov (United States)

    Rudloff, Udo; Bhanot, Umesh; Gerald, William; Klimstra, David S; Jarnagin, William R; Brennan, Murray F; Allen, Peter J

    2010-08-01

    Tissue banking has become a major initiative at many oncology centers. The influence of warm ex-vivo ischemia times, storage times, and biobanking protocols on RNA integrity and subsequent microarray data is not well documented. A prospective institutional review board-approved protocol for the banking of abdominal neoplasms was initiated at Memorial Sloan-Kettering Cancer Center in 2001. Sixty-four representative pancreas cancer specimens snap-frozen at various ex-vivo procurement times (1 h) and banked during three time periods (2001-2004, 2004-2006, 2006-2008) were processed. RNA integrity was determined by microcapillary electrophoresis using the RNA integrity number (RIN) algorithm and by results of laser-capture microdissection (LCM). Overall, 42% of human pancreas cancer specimens banked under a dedicated protocol yielded RNA with a RIN of > or =7. Limited warm ex-vivo ischemia times did not negatively impact RNA quality (percentage of tissue with total RNA with RIN of > or =7 for 60 min, 42%), and long-term storage of banked pancreas cancer biospecimens did not negatively influence RNA quality (total RNA with RIN of > or =7 banked 2001-2004, 44%; 2004-2006, 38%; 2006-2008, 50%). RNA retrieved from pancreatic cancer samples with RIN of > or =7 subject to LCM yielded RNA suitable for further downstream applications. Fresh-frozen pancreas tissue banked within a standardized research protocol yields high-quality RNA in approximately 50% of specimens and can be used for enrichment by LCM. Quality of tissues of the biobank were not adversely impacted by limited variations of warm ischemia times or different storage periods. This study shows the challenges and investments required to initiate and maintain high-quality tissue repositories.

  17. Experience in procurement and processing of heart valves at the Northwest Tissue Center

    International Nuclear Information System (INIS)

    Strong, M.; O'Neal, P.D.; Gage, H.N.; Moogk, M.

    1999-01-01

    The Northwest Tissue Center established a human heart valve program in 199 1. It is one of four non-profit tissue banks and one for-profit program that recover and process heart valves in the United States. During the eight years in which the Northwest Tissue Center has been involved in heart valve banking, there have been a total of 673 hearts procured for processing. The age of the donors ranged from <1 to 44 years with a mean of 26.2 years, 66% werw male,and 6.5% of the hearts procered were discarded due to a variety of medical and criteria reason. The primary reasons for differal were questions of possible cancer and questions of high risk behavior/social history. Of the 1,264 cardiovascular tissues processed, 6% were lost because of donor history, 17% were lost because of microbiology results, and 5% were lost because of donor serology . There were total a total of 190 aortic valves and 48 pulmonic conduits transplanted over this time period. The mean age of the recipients was 23.4 with a median or 23 years; 102 of the recipients were less than one year of age. Males comprised 62% of the recipients. Since 1993, there has been a clear shift towards more use of pulmonic valves over aortic valves as a results of the acceptance of the Ross procedure. Early in the program, reports were received from surgeons that some heart valves appeared to have cracks in the conduits. Experimentations in the laboratory led to the discovery that thawing too rapidly would result in cracking of these materials. Packaging was designed to reduce the rate of thawing and this has resolved the problem with cracking. The heart valve program at the Northwest Tissue Center has been very successful in providing the necessary valves for patients in the Northwest Region of the United States

  18. Organ procurement: Spanish transplant procurement management.

    Science.gov (United States)

    Manyalich, Martí; Mestres, Carlos A; Ballesté, Chloë; Páez, Gloria; Valero, Ricard; Gómez, María Paula

    2011-06-01

    Transplantation is an accepted therapeutic option to save or improve the quality of life when organ failure occurs or tissue replacements are needed. However, the lack of organs is the major limitation. The deceased organ procurement organization and professionals provide the solution to this international problem. In this review, we identify the elements involved in the organ procurement management process to analyze the possibility of implementation of deceased organ procurement for a transplantation program. While the donation rates are subject to several negative factors including religious, economic, cultural, and legal issues, the existence of well-trained professionals may considerably increase them. Professional training in organ donation along with the establishment of a solid organizational system has been identified as the crucial factor in developing efficient organ donation and transplantation programs.

  19. The World Bank Group and Public Procurement--An Independent Evaluation : Volume 1. Building Procurement Capacity and Systems

    OpenAIRE

    Independent Evaluation Group

    2014-01-01

    Good public procurement practices are a major determinant of the effectiveness of public expenditure. On behalf of their citizens, governments typically spend as much as 5-20 percent of their gross domestic product on procurement of goods and services, and effective procurement policies enable better use of government budgets. Good national procurement practices are therefore an essential ...

  20. The development of public and private construction procurement systems in the Malaysian construction industry

    Directory of Open Access Journals (Sweden)

    Mastura Jaafar

    2012-12-01

    Full Text Available As demand on building construction projects rises, various procurement methods have been adapted to suit with unique project requirements. However, poor industry performance and rapid developments within it indicate the need for a research on the procurement systems in the industry. In order to explore the development of procurement systems in Malaysia, a discussion on different economic phases which influence the routes of procurement systems and its evolution in Malaysia's construction industry is initiated. Subsequently, based on a questionnaire survey collected from 73 public and 68 private parties, the significant and dominant role of traditional procurement system used by both the public and private sectors in Malaysia can be confirmed. Further, compared to the public sector, the private sector is observed to be more aggressive in adapting alternative systems such as design and build (D&B and Turnkey. Further elaboration on the research findings is covered in the discussion section.

  1. Flexible procurement systems is key to supply chain sustainability

    Directory of Open Access Journals (Sweden)

    Surajit Bag

    2016-04-01

    Full Text Available Background: In this dynamic business environment, manufacturers are focusing primarily on delivery performance and competitive pricing to win orders. It is essential that manufacturers adopt flexible procurement systems (FPSs in such an uncertain environment for business sustainability. Objectives: The purpose of the study is to identify the elements of FPSs and model the interrelationships between elements of FPSs and, finally, to understand how FPSs are linked with supply chain sustainability. Method: Besides providing a brief conceptual review of FPSs, the study largely illustrates the use of an innovative multi-criteria decision-making approach called total interpretive structural modelling (TISM. Results: The total interpretive structural modelling–based model evaluates the causality and illustrates elements with interpretation of relations and suggests that bottom-level elements are vital for sustainability in FPSs and avert risks. Secondly, strategic sourcing is positively influencing supplier integration. Thirdly, supplier integration positively influences supplier responsiveness. Fourthly, skills of flexible procurement workforce positively influence supplier integration. Fifthly, it is found that supplier integration positively influences flexible transportation. The sixth finding suggests that supplier integration positively influences eco-friendly packaging. The seventh finding highlights that supplier integration positively influences ISO 14001 certifications. The eighth finding explains that supplier responsiveness positively influences customer satisfaction. It is also observed that flexible transport reduces operational cost and environmental costs. The second last finding explains eco-friendly packaging and reduction in environmental cost by careful selection of packing material and chemicals. Lastly, it is found that ISO 14001/environmental certifications reduce environmental costs by greening suppliers and pressurises them

  2. Institutional and Organizational Structure of the Federal Procurement System of the United States

    Directory of Open Access Journals (Sweden)

    Vovchenko Natalya Gennadyevna

    2015-09-01

    Full Text Available The paper deals with the role of the Federal procurement system of the United States as a regulatory tool of the U.S. economy. The scope of research is focused on organizational and institutional aspects of forming and developing the U.S. Federal procurement system. The main purpose of the paper is to study up-to-date mechanism of government acquisition in the United States and to consider all its structural elements taken in conjunction with each other, such as the President, the Office of Management and Budget (OMB, the Office of Federal Procurement Policy (OFPP, the General Services Administration (GSA, other executive and regulatory agencies. The methodological background of the research is based on normative, system-wide, statistical and complex approaches to the study of structural elements of the U.S. Federal procurement system. The theoretical and practical material of the present research can be used in teaching and learning activities at economic faculties, for instance, in the course of lectures on government contacting and public procurement management. It also can be used in training and advanced training of specialists who draft public procurement regulations in the Russian Federation. The statutory regulation of the U.S. Federal procurement system constitutes an organizational framework of executive agencies, their functions and responsibilities, specifics of government control over contract performance, competition requirements and contracting methods. The paper considered interrelated components of the U.S. Federal procurement system, which operates in furtherance of efficient utilization of Federal budget.

  3. Building Procurement

    DEFF Research Database (Denmark)

    Andersson, Niclas

    2007-01-01

    evolves from a simple establishment of a contractual relationship to a central and strategic part of construction. The authors relate to cultural, ethical and social and behavioural sciences as the fundamental basis for analysis and understanding of the complexity and dynamics of the procurement system......‘The procurement of construction work is complex, and a successful outcome frequently elusive’. With this opening phrase of the book, the authors take on the challenging job of explaining the complexity of building procurement. Even though building procurement systems are, and will remain, complex...... despite this excellent book, the knowledge, expertise, well-articulated argument and collection of recent research efforts that are provided by the three authors will help to make project success less elusive. The book constitutes a thorough and comprehensive investigation of building procurement, which...

  4. FORMATION OF THE PUBLIC PROCUREMENT SYSTEM IN THE EURASIAN ECONOMIC UNION

    Directory of Open Access Journals (Sweden)

    Vladimir Vladimirovich Savchenko

    2016-01-01

    Full Text Available The study revealed aspects of the organization of public procurement in the Eurasian Economic Union, outlines approaches to the study of the role of procurement management system in the formation of industrial capabilities to carry out competition in the market activity. The article assesses the eff ectiveness of the fi nancial mechanism in the public procurement system and discusses the dynamics of the procurement process and its features by using the most common competitive methods of procurement. The purpose / goal. The aim of the article is to identify further ways to optimize public procurement system in the Eurasian Economic Union. Tasks article. Develop an acceptable doctrinal foundations for today system of organization of public procurement in the Eurasian Economic Union. Methodology. The author began his research with the setting and the formation of the research objectives. The author defi ned the subject of the study, prepared by the empirical basis of the study. In terms of methodology, this work is an analytical and historical overview of the economic and socio-political processes taking place at the level of individual countries, regions of the world, and the world economy as a whole. Results. This article provides practical recommendations that can be used to create an eff ective integrated system of public procurement in the Eurasian Economic Union.

  5. Report on the Audit of the Procurement of the Combined Arms Training-Integrated Evaluation System

    Science.gov (United States)

    1990-05-23

    This is our final report on the Audit of the Procurement of the Combined Arms Training-Integrated Evaluation System (CATIES). We made the audit from...January through September 1989 in response to a Hotline complaint alleging irregularities in the procurement of CATIES. The audit objectives were to

  6. Economic analysis of the influence of milk market concentration on procurement efficiency in the defense system

    Directory of Open Access Journals (Sweden)

    Mihajlović Milan

    2016-01-01

    Full Text Available Increasing efficiency during realization of procurements in the defence system imposes the requirement to analyze the market, in order to detect all of its characteristics and to make conclusions which would benefit during planning of budgetary assets by one comprehensive process. Procuring milk and milk products represents a significant part of defence system's procurements which represents that a significant segment of the consumer standard of the Serbian Army, which implies the interest of authors to point to the significance of the concentration of the supply branch on the realization of procurements on the example of this market. The aim of this paper is to display the state and actual trends on the market of production and processing of milk, define methodological framework and point to the intensity and terms of competition and their influence on procurement criteria, especially price in the defence system of the Republic of Serbia.

  7. quality assurance systems in nuclear fuel procurement and manufacturing

    International Nuclear Information System (INIS)

    Can, S.

    1997-01-01

    Quality is the totality of features and characteristics of a product or service that bear on its ability to satisfy stated or implied needs. Quality control is activities and techniques used to fulfill the requirements of quality. Quality assurance is a system and its main components are requirements. QA program, organization and responsibilities, design and verification, material and its control, manufacturing and process control, inspections, audits and documents: manuals, specifications, instructions. Quality assurance systems are largely based on ISO 9000 series of the International Standards Organization. ISO 9000 series has been adopted and published by Turkish Standards Institute as TS-ISO 9000. International Atomic Energy Agency also published a guide (50-SG-QA11) ''Quality Assurance in the Procurement, Design and Manufacture of Nuclear Fuel Assemblies'' in the safety guide series. In this study the role of quality control in quality assurance systems, inspection and test plans and acceptance and nonconformance quality levels will be explained in relation to nuclear fuel production. Examples of applications in quality assurance systems based on ISO 9000 will be given

  8. Applying e-procurement system in the healthcare: the EPOS paradigm

    Science.gov (United States)

    Ketikidis, Panayiotis H.; Kontogeorgis, Apostolos; Stalidis, George; Kaggelides, Kostis

    2010-03-01

    One of the goals of procurement is to establish a competitive price, while e-procurement utilises electronic commerce to identify potential sources of supply, to purchase goods and services, to exchange contractual information and to interact with suppliers. Extensive academic work has been extensively devoted to e-procurement in diverse industries. However, applying e-procurement in the healthcare sector remains unexplored. It lacks an efficient e-procurement mechanism that will enable hospitals and healthcare suppliers to electronically exchange contractual information, aided by the technologies of optimisation and business rules. The development and deployment of e-procurement requires a major effort in the coordination of complex interorganisational business process. This article presents an e-procurement optimised system (EPOS) for the healthcare marketplace, a complete methodological approach for deploying and operating such system, as piloted in public and private hospitals in three European countries (Greece, Spain and Belgium) and suppliers of healthcare items in the fourth country (Italy). The efficient e-procurement mechanism that EPOS suggests enables hospitals and pharmaceutical and medical equipment suppliers to electronically exchange contractual information.

  9. Setup and organisation of a NDA-system procurement project

    International Nuclear Information System (INIS)

    Botte, John; Gielen, Paul

    2007-01-01

    Belgoprocess is momentarily in the process of purchasing its fifth NDA-system. Measurement systems are, although based on general designs, not from the shelf items but tailor-made sophisticated and highly automated devices. It is obvious that such a project cannot be carried out by solely a NDA team, but needs a multifunctional team. This team combines NDA expertise with experts in civil works, electrical and mechanical engineering, procurement, IT, safety and legal administration. From less positive experiences in the past, Belgoprocess learned a lot and has now a systematic in place. This systematic structures the project from definition of requirements to operation, a two to three year process. This paper defines the phases of a NDA project and gives for each phase some do's and don'ts. A second subject is the writing and handling of the vast but needed and required documentation. It gives a brief overview of the over thirty documents and files needed. The described, integrated and formal approach reduces the risk of failing projects, systems not meeting the expectations or denied qualification. It puts clear agreements in place, smoothening the relationship between company, supplier and authorities. (authors)

  10. Corruption and innovation in the Albanian public procurement system

    OpenAIRE

    Reida Kashta

    2014-01-01

    This paper examines the measures and means used to fight against corruption in public procurement in Albania. Because public procurement is one of the key areas where the public sector and the private sector interact financially and this interaction is based on public money, it is a prime candidate for corrupt activity, cronyism and favoritism as well as outright bribery. The question marks that this paper raises are: what are the means used in the war against corruption in the public ...

  11. Changes in the organ procurement system in South Korea: effects on brain-dead donor numbers.

    Science.gov (United States)

    Lee, S D; Kim, J H

    2009-11-01

    In Korea, the Organ Transplantation Act came into effect in 2000, establishing the Korean Network for Organ Sharing (KONOS) with centralized authority for organ procurement as well as for approval of donors and recipients to ensure fair organ allocation. However, the number of brain-dead donors decreased sharply, and the organ allocation system proved inefficient. The government revised the Organ Transplantation Act in August 2002, introducing an incentive system. If a transplantation hospital formed a Committee for Brain Death Evaluation and a Hospital Organ Procurement Organization, it could receive a kidney from a brain dead-donor as an incentive to foster organ procurement regardless of the KONOS wait list. The government also launched a pilot brain-dead donor registry program to strengthen Hospital Organ Procurement Organization activity. If local hospitals collaborated with specialized hospitals in organ procurement, local hospitals obtained financial incentives. But because the organ shortage problem has not been resolved, the government has proposed four initiatives: first, broadening the incentive system, which makes it possible to give each specialized hospital a choice of one of eight organs from each donor as an incentive; second, development of an Independent Organ Procurement Organization; third introduction of an opt-out system; and last, improvement of the Committee for Brain Death Evaluation system. It is uncertain which initiatives will be adopted, but changes in organ procurement systems are nonetheless considered a key to solve the organ shortage problem in Korea.

  12. NASA's Electronic Procurement System and the Impact on Small Business

    Science.gov (United States)

    Dozier, Ken

    1998-01-01

    Three workshops, held in Lancaster, Orange County and Compton, were produced by the Los Angeles Regional Technology Alliance (LARTA) and NASA Far West Technology Transfer Center (FWRTTC). The workshops were held on December 12, 1997, February 5, 1998, and March 30, 1998, respectively. The purpose behind these workshops was to spread information regarding NASA procurement opportunities to small businesses in the region. This was accomplished by inviting economic and business development organizations to the three workshops, presenting NASA procurement resources to them, and asking them to distribute this information to the small businesses in their communities. With the assistance of LARTA, marketing and publicity in the form of direct mail, telemarketing, and promotion via a web site was implemented to publicize the workshops. These methods were remarkably effective because they enabled the workshops to attain its full capacity. Further publicity was provided by Wendy Reed of Valley Focus Magazine, an Antelope Valley Magazine aimed at business people. Her article entitled, "Doing Business with the Government" recapped the Lancaster workshop that she had attended and made references to several presentations. In the article, she discussed selling to the government via electronic commerce, and specifically mentioned Robert Medina, the NASA Dryden Small Business Specialist, as a contact person for those interested in pursuing procurement opportunities. The feedback provided by the participants is illustrated by the enclosed graphs and charts. These figures represent the number of participants who have frequented web sites presented at workshops, specifically the NASA procurement resources, and how extensive information dissemination was. Input from participants was favorable and encouraged more NASA Dryden workshops directly to the small business communities. There was an overwhelming response to the benefit of the NASA procurement opportunities presented at the

  13. Selection of procurement systems in the South African construction industry: An exploratory study

    Directory of Open Access Journals (Sweden)

    W. D. Thwala

    2012-12-01

    Full Text Available Purpose of this paper: Procurement systems are vital in ensuring the successful implementation of construction projects precisely in all the phases of any particular project. Therefore, this paper aims to investigate in a systematic manner the factors that influence the selection of a procurement system in the South African construction industry. Research methodology: An extensive theory and literature review of procurement systems was conducted. The literature reviewed included a sample of case studies of procurement systems successfully implemented in completed building and civil engineering projects in South Africa. A questionnaire using a four-round Delphi survey method was used to conduct the empirical study in order to obtain participants' opinions about factors influencing the selection of procurement systems as well as the utility value of various procurement systems on each factor as identified. Finally, data analysis of both qualitative and quantitative techniques was performed using the Statistical Package for Social Sciences (SPSS. Findings: After qualitative analysis, findings of the literature reviewed suggest that factors that influence the selection of procurement systems cut across all the phases of the project as identified in this paper. Therefore, these factors are categorically classified into internal and external factors. Factors from the internal environment were further classified into client characteristics and project characteristics, with client characteristics comprising of variables such as clients' level of knowledge and control, political and social consideration, familiarity of procurement systems, competition, funding arrangement, government public/private sector projects and risk allocation whereas project characteristics comprise of factors (variables such as size and technical complexity of the project, influence of the project life cycle, expedited project delivery, time, quality and price certainty. Factors

  14. MONITORING OF THE ACTIVITY OF PUBLIC PROCUREMENT SYSTEM IN COUNTRIES OF EUROPEAN UNION AND UKRAINE

    Directory of Open Access Journals (Sweden)

    Iryna Ksonzhyk

    2017-12-01

    Full Text Available The research objective is to study and summarize the experience of the European Union countries in the field of public procurement monitoring; to study the activities that form its mechanism; to analyse forms of monitoring. Also, the current state, problems and prospects of creation and implementation of the mechanism for public procurement monitoring in Ukraine are studied; administrative and corruption risks are revealed. Methodology. Theoretical and methodological backgrounds of the research are formed on the basis of the provisions, categories, and concepts of economic theory, national and world economy, strategic development of public procurement, modelling. Laws and regulations that are regulators of the public procurement system and its monitoring, the works of domestic and foreign scientists on investigated issues were of greater importance. The system-structural analysis and synthesis, general scientific methods and methods of economic research are used to analyse and evaluate the phenomena and processes that accompany the functioning of the public procurement market and the mechanism for its monitoring. In particular, historical and dialectical methods (when studying the development of public procurement system in Western countries, the definition of stages and trends in its formation, the development and adoption of treaties for the regulation of public procurement within the European Union; method of expert assessments (for assessing the regulatory and legal support for public procurement monitoring; abstractlogical method (when establishing the factors for the formation of a monitoring mechanism in the field of public procurement in Ukraine, in particular, the institutional and organizational-economic features of its implementation, when assessing the criteria and performance indicators for the functioning of the monitoring system and its impact on the public procurement market, for theoretical generalization and conclusions

  15. Research on Appraisal System of Procurator Performance by Using High-Order CFA Model

    Directory of Open Access Journals (Sweden)

    Yong-mao Huang

    2014-01-01

    Full Text Available The prosecutor is the main body of procuratorial organs. The performance appraisal system plays an important role in promoting the work efficiency of procurator. In this paper, we establish the performance appraisal system of procurators by high-order confirmatory factor analysis method and evaluate procurators’ performance by fuzzy comprehensive evaluation method based on the 360 degrees. The results have some help to performance management of procuratorial organs.

  16. The Behavior of Procurement Process as Described by Using System Dynamics Methodology

    OpenAIRE

    Mohd Yusoff, Mohd Izhan

    2018-01-01

    System dynamics methodology has been used in many fields of study which include supply chain, project management and performance, and procurement process. The said methodology enables the researchers to identify and study the impact of the variables or factors on the outcome of the model they developed. In this paper, we showed the use of system dynamics methodology in studying the behavior of procurement process that is totally different from those mentioned in previous studies. By using a t...

  17. ANALYSIS OF THE PRACTICE OF CORRUPTION IN ELECTRONIC PROCUREMENT SERVICE SYSTEM IN THE KEPULAUAN RIAU PROVINCE

    Directory of Open Access Journals (Sweden)

    Rendra Setyadiharja

    2017-10-01

    Full Text Available Procurement of goods and services in Indonesia has carried out a number of reforms, ranging from conventional forms filled with indications of bribery and corrupt, now converted into a system of procurement of goods and services electronically with Electronic Procurement Service Systems(LPSE.Expectations the central government and local government is to minimize the occurrence of graft, a fictitious project, mark up or transactional in the procurement of goods and services, but also LPSE system has never been separated from the threat of any indication of corruption in the procurement of goods and services. The purpose of this research was to uncover a number of corrupt practices that occur on the LPSE system in Kepulauan Riau Province. The method used was the exploratory qualitative approach. Data collection method used is by interview (indebt interview. The results of this research are descriptions of cases of corruption in the LPSE system in Kepulauan Riau Province, and the mode of operation corruption practices that occur in the LPSE system in Kepulauan Riau province.

  18. Does Pharmaceutical Pricing Transparency Matter? Examining Brazil's Public Procurement System.

    Science.gov (United States)

    Kohler, Jillian Clare; Mitsakakis, Nicholas; Saadat, Faridah; Byng, Danalyn; Martinez, Martha Gabriela

    2015-08-04

    We review procurement and pricing transparency practices for pharmaceutical products. We specifically focus on Brazil and examine its approach to increasing pricing transparency, with the aim of determining the level of effectiveness in lower prices using a tool (Banco de Preços em Saúde, BPS) that only reveals purchase prices as compared to other tools (in other countries) that establish a greater degree of price transparency. A general report of Preços em Saúde (BPS) and Sistema Integrado de Administração de Serviços Gerais (SIASG) pricing data was created for 25 drugs that met specific criteria. To explore the linear time trend of each of the drugs, separate regression models were fitted for each drug, resulting in a total of 19 models. Each model controlled for the state variable and the interaction between state and time, in order to accommodate expected heterogeneity in the data. Additionally, the models controlled for procurement quantities and the effect they have on the unit price. Secondary analysis using mixed effects models was also carried out to account for the impact that institutions and suppliers may have upon the unit price. Adjusting for these predictor variables (procurement quantities, supplier, purchasing institution) was important to determine the sole effect that time has had on unit prices. A total of 2 x 19 = 38 models were estimated to explore the overall effect of time on changes in unit price. All statistical analyses were performed using the R statistical software, while the linear mixed effects models were fitted using the lme4 R package. The findings from our analysis suggest that there is no pattern of consistent price decreases within the two Brazilian states during the five-year period for which the prices were analyzed. While the BPS does allow for an increase in transparency and information on drug purchase prices in Brazil, it has not shown to lead to consistent reductions in drug purchase prices for some of the most

  19. Children as donors: a national study to assess procurement of organs and tissues in pediatric intensive care units.

    Science.gov (United States)

    Siebelink, Marion J; Albers, Marcel J I J; Roodbol, Petrie F; Van de Wiel, Harry B M

    2012-12-01

    A shortage of size-matched organs and tissues is the key factor limiting transplantation in children. Empirical data on procurement from pediatric donors is sparse. This study investigated donor identification, parental consent, and effectuation rates, as well as adherence to the national protocol. A national retrospective cohort study was conducted in all eight Dutch pediatric intensive care units. Records of deceased children were analyzed by an independent donation officer. Seventy-four (11%) of 683 deceased children were found to be suitable for organ donation and 132 (19%) for tissue donation. Sixty-two (84%) potential organ donors had been correctly identified; the parental consent and effectuation rate was 42%. Sixty-three (48%) potential tissue donors had been correctly identified; the parental consent and effectuation rate was 27%. Correct identification increased with age (logistic regression, organs: P = .024; tissues: P = .011). Although an overall identification rate of 84% of potential organ donors may seem acceptable, the variation observed suggests room for improvement, as does the overall low rate of identification of pediatric tissue donors. Efforts to address the shortage of organs and tissues for transplantation in children should focus on identifying potential donors and on the reasons why parents do not consent. © 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.

  20. Endoscopic versus transcranial procurement of allograft tympano-ossicular systems: a prospective double-blind randomized controlled audit.

    Science.gov (United States)

    Caremans, Jeroen; Hamans, Evert; Muylle, Ludo; Van de Heyning, Paul; Van Rompaey, Vincent

    2016-06-01

    Allograft tympano-ossicular systems (ATOS) have proven their use over many decades in tympanoplasty and reconstruction after resection of cholesteatoma. The transcranial bone plug technique has been used in the past 50 years to procure en bloc ATOS (tympanic membrane with malleus, incus and stapes attached). Recently, our group reported the feasibility of the endoscopic procurement technique. The aim of this study was to assess whether clinical outcome is equivalent in ATOS acquired by using the endoscopic procurement technique compared to ATOS acquired by using the transcranial technique. A double-blind randomized controlled audit was performed in a tertiary referral center in patients that underwent allograft tympanoplasty because of chronic otitis media with and without cholesteatoma. Allograft epithelialisation was evaluated at the short-term postoperative visit by microscopic examination. Failures were reported if reperforation was observed. Fifty patients underwent allograft tympanoplasty: 34 received endoscopically procured ATOS and 16 received transcranially procured ATOS. One failed case was observed, in the endoscopic procurement group. We did not observe a statistically significant difference between the two groups in failure rate. This study demonstrates equivalence of the clinical outcome of allograft tympanoplasty using either endoscopic or transcranial procured ATOS and therefore indicates that the endoscopic technique can be considered the new standard procurement technique. Especially because the endoscopic procurement technique has several advantages compared to the former transcranial procurement technique: it avoids risk of prion transmission and it is faster while lacking any noticeable incision.

  1. Pakistan, Sindh Province - Baseline Indicators System : Baseline Procurement Performance Assessment Report

    OpenAIRE

    World Bank

    2009-01-01

    This document provides an assessment of the public procurement system in Sindh province using the baseline indicators system developed by the Development Assistance Committee of the Organization for Economic Cooperation and Development (OECD-DAC). This assessment, interviews and discussions were held with stakeholders from the public and private sectors as well as civil society. Developing...

  2. Ukraine : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2001-01-01

    The main objectives of the country procurement assessment are to diagnose the public procurement system in Ukraine, assess compatibility of the country's laws, policies and procedures with international best practices, review compliance with the procurement laws and regulations and identify areas for improvement of the procurement system in Ukraine. With due recognition of the considerable...

  3. An analytical Study on Dynamics of Public Procurement System and Bidding-Strategy in Local Contractor's Management

    Science.gov (United States)

    Ninomiya, Hitoshi; Nanerikawa, Susumu

    Public procurement system such as Overall-Evaluation dynamically has been changed on local public works in Japan. However some characteristics of Bidding-Strategy and procurement system have not enough clarified. This paper attempt to analysis for a syatem dynamics and mechanisum of Overall-Evaluation by developing new simulation model focused on Bidding-Strategy, to propose some improvement scenario.

  4. A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

    NARCIS (Netherlands)

    Carithers, Latarsha J.; Ardlie, Kristin; Barcus, Mary; Branton, Philip A.; Britton, Angela; Buia, Stephen A.; Compton, Carolyn C.; Deluca, David S.; Peter-Demchok, Joanne; Gelfand, Ellen T.; Guan, Ping; Korzeniewski, Greg E.; Lockhart, Nicole C.; Rabiner, Chana A.; Rao, Abhi K.; Robinson, Karna L.; Roche, Nancy V.; Sawyer, Sherilyn J.; Segrè, Ayellet V.; Shive, Charles E.; Smith, Anna M.; Sobin, Leslie H.; Undale, Anita H.; Valentino, Kimberly M.; Vaught, Jim; Young, Taylor R.; Moore, Helen M.; Barker, Laura; Basile, Margaret; Battle, Alexis; Boyer, Joy; Bradbury, Debra; Bridge, Jason P.; Brown, Amanda; Burges, Robin; Choi, Christopher; Colantuoni, Deborah; Cox, Nancy; Dermitzakis, Emmanouil T.; Derr, Leslie K.; Dinsmore, Michael J.; Erickson, Kenyon; Fleming, Johnelle; Flutre, Timothée; Foster, Barbara A.; Gamazon, Eric R.; Getz, Gad; Gillard, Bryan M.; Guigo, Roderic; Hambright, Kenneth W.; Hariharan, Pushpa; Hasz, Rick; Im, Hae K.; Jewell, Scott; Karasik, Ellen; Kellis, Manolis; Kheradpour, Pouya; Koester, Susan; Koller, Daphne; Konkashbaev, Anuar; Lappalainen, Tuuli; Little, Roger; Liu, Jun; Lo, Edmund; Lonsdale, John T.; Lu, Chunrong; MacArthur, Daniel G.; Magazine, Harold; Maller, Julian B.; Marcus, Yvonne; Mash, Deborah C.; McCarthy, Mark I.; McLean, Jeffrey; Mestichelli, Bernadette; Miklos, Mark; Monlong, Jean; Mosavel, Magboeba; Moser, Michael T.; Mostafavi, Sara; Nicolae, Dan L.; Pritchard, Jonathan; Qi, Liqun; Ramsey, Kimberly; Rivas, Manuel A.; Robles, Barnaby E.; Rohrer, Daniel C.; Salvatore, Mike; Sammeth, Michael; Seleski, John; Shad, Saboor; Siminoff, Laura A.; Stephens, Matthew; Struewing, Jeff; Sullivan, Timothy; Sullivan, Susan; Syron, John; Tabor, David; Taherian, Mehran; Tejada, Jorge; Temple, Gary F.; Thomas, Jeffrey A.; Thomson, Alexander W.; Tidwell, Denee; Traino, Heather M.; Tu, Zhidong; Valley, Dana R.; Volpi, Simona; Walters, Gary D.; Ward, Lucas D.; Wen, Xiaoquan; Winckler, Wendy; Wu, Shenpei; Zhu, Jun

    2015-01-01

    The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for

  5. Measuring transparency in public spending: Case of Czech public e-procurement information system

    OpenAIRE

    Chvalkovská, Jana; Skuhrovec, Jiří

    2010-01-01

    The objective of this paper is to analyze the potential of e-Government tools to enable the general public to oversee spending of public institutions. The paper illustrates the “watchdog” potential of reducing corruption by means of providing information to the public on the example of the Czech Public e-Procurement Information System (further called System). The System is an Internet portal, where public authorities announce their intention to purchase goods and services. Such announcements ...

  6. The Influence of Tissue Procurement Procedures on RNA Integrity, Gene Expression, and Morphology in Porcine and Human Liver Tissue

    Czech Academy of Sciences Publication Activity Database

    Kap, M.; Sieuwerts, A.M.; Kubista, Mikael; Oomen, M.; Arshad, S.; Riegman, P.

    2015-01-01

    Roč. 13, č. 3 (2015), s. 200-206 ISSN 1947-5535 Institutional support: RVO:86652036 Keywords : WARM ISCHEMIA * SPECIMENS * FROZEN TISSUE * PURPOSE Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.804, year: 2015

  7. Decision support in hierarchical planning systems: The case of procurement planning in oil refining industries

    DEFF Research Database (Denmark)

    Kallestrup, Kasper Bislev; Lynge, Lasse Hadberg; Akkerman, Renzo

    2014-01-01

    In this paper, we discuss the development of decision support systems for hierarchically structured planning approaches, such as commercially available advanced planning systems. We develop a framework to show how such a decision support system can be designed with the existing organization in mind...... and from the perspective of the organizational aspects involved. To exemplify and develop our framework, we use a case study of crude oil procurement planning in the refining industry. The results of the case study indicate an improved organizational embedding of the DSS, leading to significant savings...... in terms of planning efforts and procurement costs. In general, our framework aims to support the continuous improvement of advanced planning systems, increasing planning quality in complex supply chain settings....

  8. Procurement specification high vacuum test chamber and pumping system

    International Nuclear Information System (INIS)

    1976-01-01

    The specification establishes requirements for a high-vacuum test chamber, associated vacuum pumps, valves, controls, and instrumentation that shall be designed and fabricated for use as a test chamber for testing a closed loop Brayton Isotope Power System (BIPS) Ground Demonstration System (GDS). The vacuum system shall include all instrumentation required for pressure measurement and control of the vacuum pumping system. A general outline of the BIPS-GDS in the vacuum chamber and the preliminary piping and instrumentation interface to the vacuum chamber are shown

  9. Arizona TeleMedicine Network: System Procurement Specifications.

    Science.gov (United States)

    Atlantic Research Corp., Alexandria, VA.

    Providing general specifications and system descriptions for segments within the Arizona TeleMedicine Project (a telecommunication system designed to deliver health services to rurally isolated American Indians in Arizona), this document, when used with the appropriate route segment document, will completely describe the project's required…

  10. Implementation of transparency and accountability under risk-based audit of electronic procurement system

    Directory of Open Access Journals (Sweden)

    M.S. Pysmenna

    2017-08-01

    Full Text Available The research analyzes the international norms and practice of realization of the purpose of state audit authorities. It is established that the activities of the state audit are aimed at improving the lives of citizens, and for this purpose the control authority, through the implementation of the principles, should achieve the goals of strengthening the principles of accountability, transparency and integrity in government and public institutions, demonstrating constant importance for citizens, parliament and other stakeholders, maintaining integrity. The study of domestic legislation on state audit in relation to compliance with international norms is conducted; the gaps and inconsistencies regarding compliance with the basic principles of transparency and accountability that ensure the purpose of the control authority activities are identified. It is determined that in order to formulate reports on the results of public procurement audits for informing the public, it is necessary to improve and apply a broader methodology of risk-based audit. The article investigates the preconditions and identifies the risks of the electronic procurement system, provides their characteristics and identifies the areas, which are negatively affected by the risks. The author identifies the information components and management functions that cannot be performed qualitatively because of the existence of risks and threats; the author also specifies the procedures for internal control over the process of administration of public procurement, and if the procedures are faced with failure, it increases the identified risks. It is proved that the proposed method of identification and evaluation of the risks of the electronic public procurement system can be used not only as a verification tool but also as the basis for compilation of reports due to the grouping of violations of the negative consequences of risks for the functioning of the system. This will ensure the

  11. Assessment of procurement systems for unutilized logging residues ...

    African Journals Online (AJOL)

    ... in the forest after clear-cutting operation with cutto- length harvesting method. ... as system-2 can be preferable for the initial supply chain configuration in Turkey. ... Key words: logging residue, forest biomass, chipping, supply cost, biomass ...

  12. The effectiveness of budget financing the system of procurement of goods, works and services for state and municipal needs

    Directory of Open Access Journals (Sweden)

    Kirillova Anna Aleksandrovna

    2016-07-01

    Full Text Available The basic components of the effectiveness of contractual procurement of goods, works and services for state and municipal needs - fiscal, social, economic, organizational. Analyzed the performance of budgetary efficiency of the procurement system according to the results of its monitoring in the years 2014-2015. It is shown that to ensure the reliability and accuracy of the quantitative evaluation of the effectiveness of budget financing of procurement data is necessary to use, fully characterize the performance of the budget impact and cost indicators, designed to receive it. It also requires the formation of an appropriate statistical database, which includes the use of the recommended indicators.

  13. Innovating the Standard Procurement System Utilizing Intelligent Agent Technologies

    Science.gov (United States)

    1999-12-01

    systems support, and such strong political backing. [Ref. 27 :p. v] b. Security Questions about EC security are justified due to frequent privacy and...17. "Federal Government Implements Acquisition Reform," Government ECommerce , http://www.oakland.ecrc.org/gov 18. Department of Navy memorandum, "FAR...34 Federal Computer Weekly, http://www.fcw.com, 28 May 1999. 48. Interview between Kuntz, Pauline, eCommerce Manager, AMS, Fairfax, VA, and the researcher

  14. In-house coordination project for organ and tissue procurement: social responsibility and promising results.

    Science.gov (United States)

    Silva, Vanessa Silva E; Moura, Luciana Carvalho; Martins, Luciana Ribeiro; Santos, Roberta Cristina Cardoso Dos; Schirmer, Janine; Roza, Bartira de Aguiar

    2016-01-01

    to report the results of evaluation regarding changes in the number of potential donor referrals, actual donors, and conversion rates after the implementation of an in-house organ and tissue donation for transplantation coordination project. epidemiological study, both retrospective and transversal, was performed with organ donation data from the Secretariat of Health for the State and the in-house organ donation coordination project of a beneficent hospital. The data was compared using nonparametric statistical Mann-Whitney test, and the Student's t-test, considering a significance level of 5% (p <0.05). there were statistically significant differences (p < 0.05), before and after the implementation of the project on the number of potential donor notification/month (3.05 - 4.7 ), number of actual donor/month (0.78 to 1.60) and rate of conversion ( 24.7 to 34.8 %). The hospitals 1, 2, 7 and 8 had significant results in potential donor, actual donor or conversion rate. the presence of an in-house coordinator is promising and beneficial, the specialist is important to change the indicators of efficiency, which consequently reduces the waiting lists for organ transplants.

  15. Soft tissue anchor systems.

    Science.gov (United States)

    Yu, G V; Chang, T; White, J M

    1994-04-01

    The concept of soft tissue attachment and reattachment has been addressed over the years through a variety of surgical techniques. This includes tendons and ligaments that have been detached both surgically and traumatically from their osseous origins or insertions. This study is designed to provide the reader with a comprehensive overview of current commercially available devices. Detailed descriptions of the various devices are provided along with a discussion of the advantages and disadvantages of each. Their application and use in reconstructive foot and ankle surgery are also discussed.

  16. Leading Efforts to Increase Organ Donation Through Professionalization of Organ Procurement Organizations and Establishment of Organ and Tissue Donor Registries.

    Science.gov (United States)

    Vertanous, T; Czer, L S C; de Robertis, M; Kiankhooy, A; Kobashigawa, J; Esmailian, F; Trento, A

    2016-01-01

    The influence of new donor registrations through the California Organ and Tissue Donor Registry on the local OneLegacy Organ Procurement Organization (OPO) was examined during a 6-year period. Publicly available data from Donate Life America for California were examined for the 6 calendar years of 2009-2014. Performance data from OneLegacy for the same 6 years for organ donors and number of transplants were also examined. The donor designation rate (DDR) was defined as the rate at which new individuals joined the state donor registry as a percentage of all driver licenses and ID cards issued within a calendar year. The total donor designation (TDD) was defined as the sum of the new and existing people who were registered organ donors. Donor designation share (DDS) was the total number of designated donors as a percentage of all residents of the state who were ≥18 years old. The business practices and educational efforts of the OneLegacy OPO were examined as well. In California, from 2009 through 2014, the DDR was 25.5%-28%. When added to the existing donor registrations, the TDD and DDS increased each year from 2009 through 2014. With the current level of growth, it is projected that California will be able to reach a DDS of 50% by 2017. For the OneLegacy OPO, designated donors from the California Organ and Tissue Donor Registry made up 15% of the total donations in 2009, and 39% of the total donations in 2014, increasing by ∼5% each year since 2009. By increasing professionalization and transparency, and widening its educational and training efforts, OneLegacy was able to take advantage of an increasing percentage of donors who were designated donors and to increase the overall number of donors and organs transplanted, becoming one of the largest OPOs in the nation. This can be a model for OPOs in other donor service areas, and it may set the stage for the United States to serve as an example to the global community in the practice of organ donation. Copyright

  17. The European contribution to the procurement of the ITER Remote Handling systems

    International Nuclear Information System (INIS)

    Damiani, Carlo; Irving, Mike; Semeraro, Luigi

    2009-01-01

    Fusion for Energy (F4E) will manage the European in-kind contribution of various remote handling (RH) systems for the maintenance of ITER components: (i) the divertor cassette movers, end effectors, manipulator arms and tooling; (ii) 50% of the transfer casks, in particular the air transfer systems and some in-cask devices; (iii) the in-vessel viewing and metrology system (IVVS); (iv) the Neutral Beam (NB) Cell crane, manipulator arms, tooling, Caesium Oven replacement tooling, NB source installation/removal trolley, auxiliary vehicles. A wide range of technologies is involved: special monorail crane, movers, manipulator arms, pipe cutting/welding tooling, special cameras, laser-based metrology devices, control systems, virtual reality. An important aspect to consider is the resistance to radiation levels that range from max ∼10 KGy/h for IVVS down to ∼1 Gy/h for the RH devices operating in the NB cell. Given the unprecedented complexity of the ITER maintenance scenario, a development strategy is being implemented that includes prototyping and testing of RH subsystems before proceeding with the final production for ITER. This paper presents an overview of the various procurement packages, the status of development for each of them, the validation and procurement strategy, including issues like radiation resistance and standardisation policy, and the organisational and managerial challenges in relation with the complex ITER Organisation (IO).

  18. Automated Procurement System (APS): Project management plan (DS-03), version 1.2

    Science.gov (United States)

    Murphy, Diane R.

    1994-01-01

    The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) is implementing an Automated Procurement System (APS) to streamline its business activities that are used to procure goods and services. This Project Management Plan (PMP) is the governing document throughout the implementation process and is identified as the APS Project Management Plan (DS-03). At this point in time, the project plan includes the schedules and tasks necessary to proceed through implementation. Since the basis of APS is an existing COTS system, the implementation process is revised from the standard SDLC. The purpose of the PMP is to provide the framework for the implementation process. It discusses the roles and responsibilities of the NASA project staff, the functions to be performed by the APS Development Contractor (PAI), and the support required of the NASA computer support contractor (CSC). To be successful, these three organizations must work together as a team, working towards the goals established in this Project Plan. The Project Plan includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  19. Lean manufacturing and Toyota Production System terminology applied to the procurement of vascular stents in interventional radiology.

    Science.gov (United States)

    de Bucourt, Maximilian; Busse, Reinhard; Güttler, Felix; Wintzer, Christian; Collettini, Federico; Kloeters, Christian; Hamm, Bernd; Teichgräber, Ulf K

    2011-08-01

    OBJECTIVES: To apply the economic terminology of lean manufacturing and the Toyota Production System to the procurement of vascular stents in interventional radiology. METHODS: The economic- and process-driven terminology of lean manufacturing and the Toyota Production System is first presented, including information and product flow as well as value stream mapping (VSM), and then applied to an interdisciplinary setting of physicians, nurses and technicians from different medical departments to identify wastes in the process of endovascular stent procurement in interventional radiology. RESULTS: Using the so-called seven wastes approach of the Toyota Production System (waste of overproducing, waiting, transport, processing, inventory, motion and waste of defects and spoilage) as well as further waste characteristics (gross waste, process and method waste, and micro waste), wastes in the process of endovascular stent procurement in interventional radiology were identified and eliminated to create an overall smoother process from the procurement as well as from the medical perspective. CONCLUSION: Economic terminology of lean manufacturing and the Toyota Production System, especially VSM, can be used to visualise and better understand processes in the procurement of vascular stents in interventional radiology from an economic point of view.

  20. Drug procurement and management.

    Science.gov (United States)

    Salhotra, V S

    2003-03-01

    A strong drug procurement and management system under the RNTCP is critical to programme success. Significant improvements in manufacturing, inspection, supply, storage and quality control practices and procedures have been achieved due to an intensive RNTCP network. Drugs used in RNTCP are rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin. Patients of TB are categorised into I, II and III and each category has a different standarised treatment. Procurement, distribution system and quality assurance of drugs are narrated in brief in this article.

  1. Public Procurement of Innovation Policy

    DEFF Research Database (Denmark)

    Rolfstam, Max; Petersen, Ole Helby

    2014-01-01

    Until recently, Danish policy interest in public procurement has mainly been driven by efficiency and cost-effectiveness concerns. Public-procurement policies have in general focused on the utilisation of economies of scale as a Means of achieving lower prices on goods and services. Attempts...... to develop mandatory procurement systems have also been gradually developing, while the focus on innovation has been relatively modest in Danish procurement policies until recently. This picture is currently changing, as several initiatives emphasising public procurement as a means of stimulating innovation...... have been launched. Whether this gradual change of focus in Danish procurement policies will make a deep and lasting impact on the role of public procurement as a driver for innovationis, however, yet an open question....

  2. The circulatory system: blood procurement, AIDS, and the social body in China.

    Science.gov (United States)

    Erwin, Kathleen

    2006-06-01

    The market for blood thrived in China for more than a decade, preying on rural villagers desperate for cash. Profit motives and unhygienic collection created an AIDS epidemic, where now up to 80 percent of adults in some villages are HIV infected. Today, illegal blood banks continue to operate in some areas. Moreover, better screening and blood testing do little to address the underlying cultural reluctance to give blood. This article examines what is at stake for blood donors in the circulation of blood through both the physical and the social bodies in China today. I argue that public health and social policy solutions require consideration of the symbolic meanings of blood and the body, kin relations, and gift exchange. China's HIV-contaminated blood procurement crisis demands a critical reexamination of the hidden processes embedded in a "circulatory system" that has inseparably bound the "gift of life" and a "commodity of death".

  3. Colombia - National Level Public Financial Management and Procurement Report : Status of the Public Financial Management and Procurement System

    OpenAIRE

    World Bank; Inter-American Development Bank

    2009-01-01

    This Public Financial Management Performance Report (PFMPR) analyzes the performance of Colombia's public financial management (PFM) institutions, systems and processes. It documents areas where performance is close to or follows international good practice, as well as opportunities to further enhance PFM contribution to the goals of strengthening fiscal discipline, enabling more efficient...

  4. Colombia - National Level Public Financial Management and Procurement Report : Status of the Colombian Public procurement System - OECD Methodology

    OpenAIRE

    World Bank

    2009-01-01

    This Public Financial Management Performance Report (PFMPR) analyzes the performance of Colombia's public financial management (PFM) institutions, systems and processes. It documents areas where performance is close to or follows international good practice, as well as opportunities to further enhance PFM contribution to the goals of strengthening fiscal discipline, enabling more efficient...

  5. Technology management: a perspective on system support, procurement, and replacement planning.

    Science.gov (United States)

    Dickerson, M L; Jackson, M E

    1992-01-01

    The escalating costs associated with medical technology present a host of challenges for the hospital clinical engineering department. As service and support costs comprise ever larger portions of a system's life cycle cost, innovative management of service provider mix and mechanisms can provide substantial savings in operating expenses. In addition to full-service contracts, the use of demand service and independents has become commonplace. Medical equipment maintenance insurance programs provide yet another service alternative, combining the flexibility of demand service with the safety of a capped budget. These programs have gained acceptance among hospitals as their providers have become more focused on the healthcare market and its many needs. In view of the long-term cost impact surrounding technology procurement, the authors recommend that hospitals refine system evaluation methodologies and develop more comprehensive techniques directed at capital equipment replacement planning. One replacement planning approach, based on an estimation of system value changes, is described and illustrated using data collected through client consultations. Although the validity of this method has not been demonstrated, it represents a simplified approach to life cycle cost analysis and is intended to provide a standard method by which system replacement planning may be quantified. As a departure from system devaluation based solely on depreciation, this method estimates prospective system values derived from anticipated operations and maintenance costs, projected revenue, and the availability of new technology.

  6. Human tissue in systems medicine.

    Science.gov (United States)

    Caie, Peter D; Schuur, Klaas; Oniscu, Anca; Mullen, Peter; Reynolds, Paul A; Harrison, David J

    2013-12-01

    Histopathology, the examination of an architecturally artefactual, two-dimensional and static image remains a potent tool allowing diagnosis and empirical expectation of prognosis. Considerable optimism exists that the advent of molecular genetic testing and other biomarker strategies will improve or even replace this ancient technology. A number of biomarkers already add considerable value for prediction of whether a treatment will work. In this short review we argue that a systems medicine approach to pathology will not seek to replace traditional pathology, but rather augment it. Systems approaches need to incorporate quantitative morphological, protein, mRNA and DNA data. A significant challenge for clinical implementation of systems pathology is how to optimize information available from tissue, which is frequently sub-optimal in quality and amount, and yet generate useful predictive models that work. The transition of histopathology to systems pathophysiology and the use of multiscale data sets usher in a new era in diagnosis, prognosis and prediction based on the analysis of human tissue. © 2013 The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS.

  7. Integration of a nationally procured electronic health record system into user work practices

    Directory of Open Access Journals (Sweden)

    Cresswell Kathrin M

    2012-03-01

    Full Text Available Abstract Background Evidence suggests that many small- and medium-scale Electronic Health Record (EHR implementations encounter problems, these often stemming from users' difficulties in accommodating the new technology into their work practices. There is the possibility that these challenges may be exacerbated in the context of the larger-scale, more standardised, implementation strategies now being pursued as part of major national modernisation initiatives. We sought to understand how England's centrally procured and delivered EHR software was integrated within the work practices of users in selected secondary and specialist care settings. Methods We conducted a qualitative longitudinal case study-based investigation drawing on sociotechnical theory in three purposefully selected sites implementing early functionality of a nationally procured EHR system. The complete dataset comprised semi-structured interview data from a total of 66 different participants, 38.5 hours of non-participant observation of use of the software in context, accompanying researcher field notes, and hospital documents (including project initiation and lessons learnt reports. Transcribed data were analysed thematically using a combination of deductive and inductive approaches, and drawing on NVivo8 software to facilitate coding. Results The nationally led "top-down" implementation and the associated focus on interoperability limited the opportunity to customise software to local needs. Lack of system usability led users to employ a range of workarounds unanticipated by management to compensate for the perceived shortcomings of the system. These had a number of knock-on effects relating to the nature of collaborative work, patterns of communication, the timeliness and availability of records (including paper and the ability for hospital management to monitor organisational performance. Conclusions This work has highlighted the importance of addressing potentially adverse

  8. Uzbekistan : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2003-01-01

    Uzbekistan inherited the Soviet system for the procurement of goods, works and services for State needs. This system was suitable for a command economy but lacks the essential elements of competitiveness, transparency and accountability, which are the hallmarks of a market-based approach to government contracting. This Country Procurement Assessment Report (CPAR) comes at a time when a num...

  9. Sustainable Procurement

    DEFF Research Database (Denmark)

    Telles, Pedro; Ølykke, Grith Skovgaard

    2017-01-01

    and within it how sustainable requirements have increased the level of compliance required, particularly regulatory compliance. Compliance was already present in previous EU public procurement frameworks, but its extent on Directive 2014/24/EU leads the authors to consider the current legal framework...

  10. Optimal Sizing of Energy Storage Systems for the Energy Procurement Problem in Multi-Period Markets under Uncertainties

    Directory of Open Access Journals (Sweden)

    Ryusuke Konishi

    2018-01-01

    Full Text Available In deregulated electricity markets, minimizing the procurement costs of electricity is a critical problem for procurement agencies (PAs. However, uncertainty is inevitable for PAs and includes multiple factors such as market prices, photovoltaic system (PV output and demand. This study focuses on settlements in multi-period markets (a day-ahead market and a real-time market and the installation of energy storage systems (ESSs. ESSs can be utilized for time arbitrage in the day-ahead market and to reduce the purchasing/selling of electricity in the real-time market. However, the high costs of an ESS mean the size of the system needs to be minimized. In addition, when determining the size of an ESS, it is important to identify the size appropriate for each role. Therefore, we employ the concept of a “slow” and a “fast” ESS to quantify the size of a system’s role, based on the values associated with the various uncertainties. Because the problem includes nonlinearity and non-convexity, we solve it within a realistic computational burden by reformulating the problem using reasonable assumptions. Therefore, this study identifies the optimal sizes of ESSs and procurement, taking into account the uncertainties of prices in multi-period markets, PV output and demand.

  11. Geographic information system-based spatial analysis of sawmill wood procurement

    Science.gov (United States)

    Nathaniel M. Anderson; Rene H. Germain; Eddie Bevilacqua

    2011-01-01

    In the sawmill sector of the forest products industry, the clustering of mills and wide variation in forest stocking and ownership result in sawlog markets that are complex and spatially differentiated. Despite the inherent spatial attributes of markets for stumpage and logs, few studies have used geospatial methods to examine wood procurement in detail across...

  12. Procurement strategic analysis of nuclear safety equipment

    International Nuclear Information System (INIS)

    Wu Caixia; Yang Haifeng; Li Xiaoyang; Li Shixin

    2013-01-01

    The nuclear power development plan in China puts forward a challenge on procurement of nuclear safety equipment. Based on the characteristics of the procurement of nuclear safety equipment, requirements are raised for procurement process, including further clarification of equipment technical specification, establishment and improvement of the expert database of the nuclear power industry, adoption of more reasonable evaluation method and establishment of a unified platform for nuclear power plants to procure nuclear safety equipment. This paper makes recommendation of procurement strategy for nuclear power production enterprises from following aspects, making a plan of procurement progress, dividing procurement packages rationally, establishing supplier database through qualification review and implementing classified management, promoting localization process of key equipment continually and further improving the system and mechanism of procurement of nuclear safety equipment. (authors)

  13. Quality system in Malaysian National Tissue Bank

    International Nuclear Information System (INIS)

    Go Boon Thong; Firdaus, M. N.; Abd Rani Shamsudin

    1999-01-01

    Quality System in Malaysian National Tissue Bank is based on the Quality Manual which has been drawn up by the chairman, who is the Dean, School of Medical Sciences. The Quality Manual include general standard for Tissue Banking in University Science of Malaysia which describe and explain a set of general standard similar to the EATB standard. The primary aim of the quality system is to produce a safe and effective tissue graft for successful clinical use and to ensure the safety of tissue bank operators. The Quality Manual also related the role of a Technical Manual, which explain the standard of technical aspect of tissue bank in a Quality Assurance. The safe working environment and Good Laboratory Practice is highlight in Quality System. Documentation of tissue bank activities is the key to the administration to tissue bank. Finally Quality System in tissue banking will never be complete without a Tissue Bank Auditing System which allow the tissue bank coordinator and staff to look into the problem and further enhance the progress of the tissue bank

  14. Application of Life Support Cost, Provisioning, and Repair/Discard Models to Weapon System Procurement Decisions by Small Countries.

    Science.gov (United States)

    1981-12-01

    the LCC for use in system evaluation was motivated by the fact that the major part of user budgets are spent on operations and support activities...Furthermore, it was recognized that these ownership costs ex- ceed systems procurement costs by up to several times. The main motivation behind the LCC...8217 󈧄 4 ~ ~ ~ ( CL f %AO 09*. 𔃾.𔃺 𔄃 0 4 . -~4 4C4 - CL44 N 10 z3 w 4 . - 4)..LIP 4 .J~272 .0co A pF 1 PS4 ~~~~m a0~-eN ON~ - .q r N0 .. ~ ~ 7O N#04

  15. Public Procurement and Forest Governance: A German Case Study of Governmental Influences on Market-Driven Governance Systems

    Directory of Open Access Journals (Sweden)

    Moritz Albrecht

    2012-09-01

    Full Text Available With increased privatization of natural resource regulation, green or sustainable public procurement policies are emerging as incentives for sustainable development. Thus, a revival of governmental influences on so-called non-state, market-driven governance systems takes place. The paper exemplifies this development by reference to the green public procurement directives for wood products in Germany and its influence on major forest certification systems and forest governance. Using an approach of governmentality in relational space, the paper displays how governmental entities play a significant role in influencing forest governance systems and the greening of markets. The importance of the underlying relations that shape governmental instruments and their influences on forest certification and governance are evaluated from a German perspective. Acknowledging the market-driven aspects of forest certification systems, the paper highlights the often-neglected impacts of governmental regulation on emerging forest governance systems. Thus, the framework allows insights into how relations among political entities and their means of knowledge production are essential for processes of forest governance.

  16. Progress in the design, R and D and procurement preparation of the ITER Divertor Remote Handling System

    Energy Technology Data Exchange (ETDEWEB)

    Esqué, Salvador, E-mail: Salvador.Esque@f4e.europa.eu [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Hille, Carine van; Ranz, Roberto; Damiani, Carlo [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Palmer, Jim; Hamilton, David [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France)

    2014-10-15

    Highlights: •The ITER Divertor Remote Handling System (DRHS) reference design is presented. •Different R and D activities that have contributed to the development and validation of the current reference design are reported. •The DRHS turns to be a unique system in terms of complexity due to size of the to-be-handled components, the novelty of the remote operations and the operational conditions. -- Abstract: The ITER Divertor Remote Handling System (DRHS) consists of a number of dedicated remote handling equipment and tooling that will provide the means to perform the exchange of the divertor system in a full-remote way. In order to achieve this objective the DRHS will need to perform a number of novel and complex remote operations in a contaminated and space-constrained environment, in rather poor lightening conditions. Fusion for Energy has recently launched the tendering phase for the in-kind procurement of the DRHS. The procurement is based on a set of system requirements and functional specifications supported by a reference design which are presented and discussed in this paper along with the main outcomes of the different R and D activities that have contributed to the development and validation of the current reference design.

  17. The organization of organ procurement.

    Science.gov (United States)

    Prottas, J M

    1989-01-01

    The American organ procurement system has improved and matured in the last five years. At the same time, the basic challenges facing it have remained substantially the same because the moral and legal framework of the system has not changed. Success at organ procurement continues to depend on the voluntary cooperation of medical professionals and the families of potential organ donors. The generosity of the American public is so great that the primary challenge facing organ procurement agencies is obtaining cooperation from hospitals and medical professionals. This calls for a "marketing" orientation aimed at those hospitals and professionals who are most likely to treat potential donors. The last five years have seen a more general acceptance of this appreciation of the central task of organ procurement. As a result, the overall effectiveness of the system has improved, as measured by the number of organs procured on a per capita basis and by the number of multiorgan donors obtained. Much of this improvement can be attributed to the diffusion of organizational techniques and approaches, and this diffusion has been encouraged by the involvement of national organizations and public bodies in the organ procurement community. The system remains uneven in its effectiveness and further improvement is possible. It is also possible that the next general round of improvement will result from the application of businesslike information management and marketing techniques.

  18. Diagnostics and Minimization of Business Risks and the State Customer in the System of Public e-Procurement

    Directory of Open Access Journals (Sweden)

    Oksana Klyuvak

    2018-01-01

    Full Text Available The purpose of the article is to develop the diagnostics of the system of public e-procurement in terms of the risks of its subjects and to develop an approach to minimize the risk associated with changes in the purchase price. It is determined that the most widespread risks in the public e-procurement system in Ukraine, classified on the basis of a subjective approach, are: 1 a conspiracy of participants in the tender process; 2 insufficient level of professionalism; 3 change of purchase price. It has been determined that risk management in the system of public e-procurement should be understood as the diagnostic process (identification, analysis, evaluation, prevention, minimization and elimination of the risks of the customer, supplier and common risks in the stages of post-accession, tender and post-tandem procedures in order to balance financial and legal interests of the state and business. It is established that calculation of the correction of the purchase price (taking into account macroeconomic fluctuations should take into account the following elements (components: 1 commodity-material element (direct commodity-material expenses as of the base date (opening of a tender offer and on the date of delivery or start of implementation of the state order; 2 the human element (labor costs (average wage, qualification upgrading by the base date (opening a tender offer and as of the date of delivery or start of execution of the state order; 3 an element related to other attendance costs (costs of bank servicing of payments, the amount of duty in the case of export-import operations, logistics costs as of the base date (opening a tender offer and as of the date of delivery or start of execution of the state order; 4 fixed item (percentage in % of purchase price. The prospect of further research in this direction is to improve the system of polycriterial diagnostics of the activities of enterprises, taking into account the presented research

  19. Green Component Procurement Collaboration for Improving Supply Chain Management in the High Technology Industries: A Case Study from the Systems Perspective

    Directory of Open Access Journals (Sweden)

    Min-Ren Yan

    2016-01-01

    Full Text Available The impacts of high technology industries have been growing increasingly to technological innovations and global economic developments, while the concerns in sustainability are calling for facilitating green materials and cleaner production in the industrial value chains. Today’s manufacturing companies are not striving for individual capacities but for the effective working with green supply chains. However, in addition to environmental and social objectives, cost and economic feasibility has become one of the most critical success factors for improving supply chain management with green component procurement collaboration, especially for the electronics OEM (original equipment manufacturing companies whose procurement costs often make up a very high proportion of final product prices. This paper presents a case study from the systems perspective by using System Dynamics simulation analysis and statistical validations with empirical data. Empirical data were collected from Taiwanese manufacturing chains—among the world’s largest manufacturing clusters of high technology components and products—and their global green suppliers to examine the benefits of green component procurement collaborations in terms of shared costs and improved shipping time performance. Two different supply chain collaboration models, from multi-layer ceramic capacitor (MLCC and universal serial bus 3.0 (USB 3.0 cable procurements, were benchmarked and statistically validated. The results suggest that the practices of collaborative planning for procurement quantity and accurate fulfillment by suppliers are significantly related to cost effectiveness and shipping time efficiency. Although the price negotiation of upstream raw materials for the collaborative suppliers has no statistically significant benefit to the shipping time efficiency, the shared cost reduction of component procurement is significantly positive for supply chain collaboration among green

  20. Efisiensi Sistem E-procurement dalam Pelelangan Umum Pengadaan Barang dan Jasa (Studi Kasus: Dinas Pekerjaan Umum Provinsi Bali)

    OpenAIRE

    Claudy, Fransiskus; Noak, Piers Andreas; Winaya, I Ketut

    2017-01-01

    E-procurement system in the procurement of government goods / services is essential to improve the efficiency of the procurement process, this is the purpose and principles of procurement process government goods / services, including the Public Works Department of Bali Province as one SKPD Bali Province who have used the e-procurement system in the procurement process. The purpose of this study was to determine the efficiency as well as the constraints of e-procurement system in the procurem...

  1. European quality system for tissue banking.

    Science.gov (United States)

    Manyalich, M; Navarro, A; Koller, J; Loty, B; de Guerra, A; Cornu, O; Vabels, G; Fornasari, P M; Costa, A N; Siska, I; Hirn, M; Franz, N; Miranda, B; Kaminski, A; Uhrynowska, I; Van Baare, J; Trias, E; Fernández, C; de By, T; Poniatowski, S; Carbonell, R

    2009-01-01

    The aims of this project were to analyze the factors that influence quality and safety of tissues for transplantation and to develop the method to ensure standards of quality and safety in relation to tissue banking as demanded by European Directive 2004/23/EC and its technical annexes. It is organized in 4 Working Groups, the objectives of each one being focused in a specific area. The Guide of Recommendations for Tissue Banking is structured into 4 parts: (1) quality systems that apply to tissue banking and general quality system requirements, (2) regulatory framework in Europe, (3) standards available, and (4) recommendations of the fundamental quality and safety keypoints. This Working Group handled design of a multinational musculoskeletal tissue registry prototype. This Working Group handled design and validation of a specialized training model structured into online and face-to-face courses. The model was improved with suggestions from students, and 100% certification was obtained. The Guide for Auditing Tissue Establishments provides guidance for auditors, a self-assessment questionnaire, and an audit report form. The effectiveness and sustainability of the outputs were assessed. Both guides are useful for experienced tissue establishments and auditors and also for professionals that are starting in the field. The registry prototype proves it is possible to exchange tissues between establishments throughout Europe. The training model has been effective in educating staff and means having professionals with excellent expertise. Member states could adapt/adopt it. The guides should be updated periodically and perhaps a European organization should take responsibility for this and even create a body of auditors.

  2. Radiological approach to systemic connective tissue diseases

    International Nuclear Information System (INIS)

    Wiesmann, W.; Schneider, M.

    1988-01-01

    Systemic lupus erythematosus (SLE) and progressive systemic sclerosis (PSS) represent the most frequent manifestations of systemic connective tissue diseases (collagen diseases). Radiological examinations are employed to estimate the extension and degree of the pathological process. In addition, progression of the disease can be verified. In both of the above collagen diseases, specific radiological findings can be observed that permit them to be differentiated from other entities. An algorithm for the adequate radiological work-up of collagen diseases is presented. (orig.) [de

  3. Radiological approach to systemic connective tissue diseases

    Energy Technology Data Exchange (ETDEWEB)

    Wiesmann, W; Schneider, M

    1988-07-01

    Systemic lupus erythematosus (SLE) and progressive systemic sclerosis (PSS) represent the most frequent manifestations of systemic connective tissue diseases (collagen diseases). Radiological examinations are employed to estimate the extension and degree of the pathological process. In addition, progression of the disease can be verified. In both of the above collagen diseases, specific radiological findings can be observed that permit them to be differentiated from other entities. An algorithm for the adequate radiological work-up of collagen diseases is presented.

  4. Discriminatory public procurement policies

    NARCIS (Netherlands)

    Ssennoga, Francis

    2010-01-01

    To achieve social economic objectives, governments usually institute discriminatory practices in their country’s public procurement framework. Discriminatory procurement is the practice by governments to favour their own domestic suppliers over foreign firms for advertised contracts. Favouring

  5. Public procurement process

    African Journals Online (AJOL)

    NESG Policy Brief: April 2017. Public ... transparency in public procurement; and greater concerns about efficiency, fairness, and equity. ... government enacted the Public Procurement Act (2007) [1] which provides legislative framework for.

  6. Risk Management in Public Procurement Process

    Directory of Open Access Journals (Sweden)

    Ioana Manea

    2010-12-01

    Full Text Available Public procurement represents an important part of the current economy reality. Throughout the procurement process, due to the effect of the interaction among the components of the public procurement system, certain actions with significant negative effects on its optimal operation may occur. Risks may turn into certainty either because of a simple error in the development and administration of the procurement process, or because of a deliberate deviation from the existing legal provisions. Therefore, there is an imperative for the implementation of certain risk-avoiding measures, as well as of measures aiming to reduce their negative effects in case of their occurrence.

  7. Qualitative analysis of round-table discussions on the business case and procurement challenges for hospital electronic prescribing systems.

    Directory of Open Access Journals (Sweden)

    Kathrin M Cresswell

    Full Text Available There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making.We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9.We drew on data from 17 participants (approximately eight per roundtable, six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing "wants" and aspirations from organizational "needs".Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management.

  8. Procurement Career Management Handbook.

    Science.gov (United States)

    Department of the Treasury, Washington, DC.

    This handbook is the result of the Treasury Department's efforts to increase professionalism among its procurement employees nationwide through its Procurement Career Management Program. First, the scope and objectives of the Procurement Career Management Program are discussed. The remaining sections of the handbook deal with the following program…

  9. Stochastic energy procurement of large electricity consumer considering photovoltaic, wind-turbine, micro-turbines, energy storage system in the presence of demand response program

    International Nuclear Information System (INIS)

    Nojavan, Sayyad; Aalami, Habib allah

    2015-01-01

    Highlights: • A stochastic energy procurement cost function in presence of DRP is proposed. • The load, price and output power of PV and wind uncertainties are modeled. • Four case studies are used to assess the effects of ESS and DRP on SEPP. • Case 4 is considered the effects of ESS and DRP simultaneously. • The expected energy procurement cost of case 4 is lower than cases 1, 2 and 3. - Abstract: This paper proposes a stochastic energy procurement problem (SEPP) for large electricity consumer (LEC) with multiple energy procurement sources (EPSs) considering the effects of demand response program (DRP) and energy storage system (ESS). The EPSs contain power market (PM), bilateral contracts (BCs), micro-turbines (MTs), and renewable energy sources (RESs). Moreover, the RESs include photovoltaic (PV) systems and wind-turbines (WT). The ESS and DRP are incorporated in the SEPP by the LEC’s decision-maker to reduce the expected energy procurement cost (EEPC). Meanwhile, the uncertainty models of market price, load and RES output power are considered in the SEPP formulation. The error of forecasting of market price, load, temperature and radiation of PV systems are modeled using the normal distribution for generating the related scenarios. Also, the weibull distribution is used to generate variable wind speed scenarios for WT output power uncertainty modeling. Furthermore, the fast forward selection based on Kantorovich distance approach is used for the scenarios reduction. Finally, the influences of ESS and DRP on EEPC are investigated, and four case studies are used to illustrate the capability of the proposed SEPP. The obtained results demonstrate the efficiency of the proposed stochastic program

  10. Corruption in emergency procurement.

    Science.gov (United States)

    Schultz, Jessica; Søreide, Tina

    2008-12-01

    Corruption in emergency procurement reduces the resources available for life-saving operations, lowers the quality of products and services provided, and diverts aid from those who need it most.(1) It also negatively influences public support for humanitarian relief, both in the affected country and abroad. This paper aims to unpack and analyse the following question in order to mitigate risk: how and where does corruption typically occur, and what can be done? Suggested strategies reflect a multi-layered approach that stresses internal agency control mechanisms, conflict-sensitive management, and the need for common systems among operators.

  11. NASA Procurement Career Development Program

    Science.gov (United States)

    1987-01-01

    The NASA Procurement Career Development Program establishes an agency-wide framework for the management of career development activity in the procurement field. Within this framework, installations are encouraged to modify the various components to meet installation-specific mission and organization requirements. This program provides a systematic process for the assessment of and planning for the development, training, and education required to increase the employees' competence in the procurement work functions. It includes the agency-wide basic knowledge and skills by career field and level upon which individual and organizational development plans are developed. Also, it provides a system that is compatible with other human resource management and development systems, processes, and activities. The compatibility and linkage are important in fostering the dual responsibility of the individual and the organization in the career development process.

  12. The European Union Joint Procurement Agreement for cross-border health threats: what is the potential for this new mechanism of health system collaboration?

    Science.gov (United States)

    Azzopardi-Muscat, Natasha; Schroder-Bäck, Peter; Brand, Helmut

    2017-01-01

    The Joint Procurement Agreement (JPA) is an innovative instrument for multi-country procurement of medical countermeasures against cross-border health threats. This paper aims to assess its potential performance. A literature review was conducted to identify key features of successful joint procurement programmes. Documentary analysis and a key informants' interview were carried out to analyse the European Union (EU) JPA. Ownership, equity, transparency, stable central financing, standardisation, flexibility and gradual development were identified as important prerequisites for successful establishment of multi-country joint procurement programmes in the literature while security of supply, favourable prices, reduction of operational costs and administrative burden and creation of professional expert networks were identified as desirable outcomes. The EU JPA appears to fulfil the criteria of ownership, transparency, equity, flexibility and gradual development. Standardisation is only partly fulfilled and central EU level financing is not provided. Security of supply is an important outcome for all EU Member States (MS). Price savings, reduction in administrative burden and creation of professional networks may be particularly attractive for the smaller MS. The JPA has the potential to increase health system collaboration and efficiency at EU level provided that the incentives for sustained commitment of larger MS are sufficiently attractive.

  13. Innovation public procurement in Russia: problems of institutional arrangements

    Directory of Open Access Journals (Sweden)

    Korytcev Maxim, A.

    2015-12-01

    Full Text Available The paper explores the problems of public procurement in innovation sphere in Russia, its institutional organization. In international practice, some strategies of innovation stimulation (by public procurement are developing. There is necessity to use more elements of these strategies in Russian National Procurement System. The active National Public Procurement System has no enough effective methods and instruments for stimulating innovation development now.

  14. public procurement, governance and economic growth

    African Journals Online (AJOL)

    GRACE

    (2003: 2), ―strong procurement management in the public sector is a tool for achieving political, economic and social goals‖. Thus .... professionalism in the public sector procurement system (Section 4, PPA, 2007). The functions and powers of the ..... K., Bose, N. and Haque, M.E. (2004). Public Expenditures, Bureaucratic.

  15. Cardiac tissue engineering using perfusion bioreactor systems

    Science.gov (United States)

    Radisic, Milica; Marsano, Anna; Maidhof, Robert; Wang, Yadong; Vunjak-Novakovic, Gordana

    2009-01-01

    This protocol describes tissue engineering of synchronously contractile cardiac constructs by culturing cardiac cell populations on porous scaffolds (in some cases with an array of channels) and bioreactors with perfusion of culture medium (in some cases supplemented with an oxygen carrier). The overall approach is ‘biomimetic’ in nature as it tends to provide in vivo-like oxygen supply to cultured cells and thereby overcome inherent limitations of diffusional transport in conventional culture systems. In order to mimic the capillary network, cells are cultured on channeled elastomer scaffolds that are perfused with culture medium that can contain oxygen carriers. The overall protocol takes 2–4 weeks, including assembly of the perfusion systems, preparation of scaffolds, cell seeding and cultivation, and on-line and end-point assessment methods. This model is well suited for a wide range of cardiac tissue engineering applications, including the use of human stem cells, and high-fidelity models for biological research. PMID:18388955

  16. Potential fraudulent behaviors in e-procurement implementation in Indonesia

    Science.gov (United States)

    Huda, S. N.; Setiani, N.; Pulungan, R.; Winarko, E.

    2017-03-01

    Corruptions in public procurement have occurred in various parts of the world, especially in developing countries. Implementation of SPSE (electronic procurement system) as the e-procurement system in Indonesia is based on the government’s intentions towards clean and good governance by fighting corruption, collusion, and nepotism. Procurement in Indonesia is carried out through SPSE, which is developed by LKPP (Government Policy on Procurement of Goods/Services). Although this system has brought many positive effects, there are still found many practices of fraud occurring in the implementation of the system. In this paper, we try to identify these practices and then to systematically categorize and analyze them.

  17. Qualitative Analysis of Round-Table Discussions on the Business Case and Procurement Challenges for Hospital Electronic Prescribing Systems

    Science.gov (United States)

    Cresswell, Kathrin M.; Slee, Ann; Coleman, Jamie; Williams, Robin; Bates, David W.; Sheikh, Aziz

    2013-01-01

    Objectives There is a pressing need to understand the challenges surrounding procurement of and business case development for hospital electronic prescribing systems, and to identify possible strategies to enhance the efficiency of these processes in order to assist strategic decision making. Materials and Methods We organized eight multi-disciplinary round-table discussions in the United Kingdom. Participants included policy makers, representatives from hospitals, system developers, academics, and patients. Each discussion was digitally audio-recorded, transcribed verbatim and, together with accompanying field notes, analyzed thematically with NVivo9. Results We drew on data from 17 participants (approximately eight per roundtable), six hours of discussion, and 15 pages of field notes. Key challenges included silo planning with systems not being considered as part of an integrated organizational information technology strategy, lack of opportunity for interactions between customers and potential suppliers, lack of support for hospitals in choosing appropriate systems, difficulty of balancing structured planning with flexibility, and the on-going challenge of distinguishing “wants” and aspirations from organizational “needs”. Discussion and conclusions Development of business cases for major investments in information technology does not take place in an organizational vacuum. Building on previously identified potentially transferable dimensions to the development and execution of business cases surrounding measurements of costs/benefits and risk management, we have identified additional components relevant to ePrescribing systems. These include: considerations surrounding strategic context, case for change and objectives, future service requirements and options appraisal, capital and revenue implications, timescale and deliverability, and risk analysis and management. PMID:24260213

  18. Regional trade agreements & procurement rules : facilitators or hindrances?

    OpenAIRE

    ANDERSON, Robert D.; MÜLLER, Anna Caroline; PELLETIER, Philippe

    2015-01-01

    This Working Paper considers the significance of government procurement chapters in regional trade agreements (RTAs), both in their own right and vis-à-vis the WTO Agreement on Government Procurement (GPA). The paper finds, inter alia, that: (i) a strong complementarity exists between government procurement trade commitments and general goods and services trade commitments, making integration of procurement commitments in a more general system such as the WTO Agreements desirable; (ii) govern...

  19. 41 CFR 101-26.507-2 - Procurement time schedule.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement time schedule. 101-26.507-2 Section 101-26.507-2 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND...

  20. 41 CFR 101-26.501-5 - Procurement time schedules.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement time schedules. 101-26.501-5 Section 101-26.501-5 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT...

  1. Pakistan : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2000-01-01

    This report analyzes Pakistan's procurement system, and presents an extensive set of recommendations for strengthening same. It reviews the legal, and regulatory framework, as well as the mandatory registration and/or pre-qualification of suppliers, and contractors, and negotiation practices, and, analyzes bidding document issues for recommendation. Human resources development, auditing pr...

  2. Waste reduction efforts through the evaluation and procurement of a digital camera system for the Alpha-Gamma Hot Cell Facility at Argonne National Laboratory-East

    International Nuclear Information System (INIS)

    Bray, T. S.; Cohen, A. B.; Tsai, H.; Kettman, W. C.; Trychta, K.

    1999-01-01

    The Alpha-Gamma Hot Cell Facility (AGHCF) at Argonne National Laboratory-East is a research facility where sample examinations involve traditional photography. The AGHCF documents samples with photographs (both Polaroid self-developing and negative film). Wastes generated include developing chemicals. The AGHCF evaluated, procured, and installed a digital camera system for the Leitz metallograph to significantly reduce labor, supplies, and wastes associated with traditional photography with a return on investment of less than two years

  3. Microelectronic Status Analysis and Secondary Part Procureability Assessment of the HAWK Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    2000-01-01

    The MT Division, Engineering Directorate (ED), RDEC, AMCOM has the mission and function of providing microelectronic technology assessments, and producibility and supportability analyses for the HAWK weapon system...

  4. Microelectronic Status Analysis and Secondary Part Procureability Assessment of the HAWK Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    1999-01-01

    The Industrial Operations Division (IOD), SEPD, RDEC, AMCOM has the mission and function of providing microelectronic technology assessments, and producibility and supportability analyses for the HAWK weapon system...

  5. System Establishment and Method Application for Quantitatively Evaluating the Green Degree of the Products in Green Public Procurement

    Directory of Open Access Journals (Sweden)

    Shengguo Xu

    2016-09-01

    Full Text Available The government green purchase is widely considered to be an effective means of promoting sustainable consumption. However, how to identify the greener product is the biggest obstacle of government green purchase and it has not been well solved. A quantitative evaluation method is provided to measure the green degree of different products of the same use function with an indicator system established, which includes fundamental indicators, general indicators, and leading indicators. It can clearly show the products’ green extent by rating the scores of different products, which provides the government a tool to compare the green degree of different products and select greener ones. A comprehensive evaluation case of a project purchasing 1635 desk computers in Tianjin government procurement center is conducted using the green degree evaluation system. The environmental performance of the products were assessed quantitatively, and the evaluation price, which was the bid price minus the discount (the discount rate was according to the total scores attained by their environmental performance, and the final evaluation price ranking from low to high in turn is supplier C, D, E, A, and B. The winner, supplier C, was not the lowest bid price or the best environmental performance, but it performed well at both bid price and environmental performance so it deserved the project. It shows that the green extent evaluation system can help classify the different products by evaluating their environment performance including structure and connection technology, selection of materials and marks, prolonged use, hazardous substances, energy consumption, recyclability rate, etc. and price, so that it could help to choose the greener products.

  6. Microelectronic Status Analysis and Secondary Part Procureability Assessment of the ATACMS-BAT Weapon System

    National Research Council Canada - National Science Library

    Maddux, Gary

    2000-01-01

    The MT Division, Engineering Directorate (ED), RDEC, AMCOM has the mission and function of providing microelectronic technology assessments, and producibility and supportability analyses for the ATACMS-BAT weapon system...

  7. War Reserve Analysis and Secondary Item Procureability Assessment of the AMCOM Supported Weapon Systems

    National Research Council Canada - National Science Library

    Maddux, Gary

    2000-01-01

    .... IOD evaluates the impacts of nonavailability of secondary items on the life cycle supportability of AMCOM weapon systems and evaluates the producibility of secondary items for war reserve requirements...

  8. Indonesia - Procurement Modernization

    Data.gov (United States)

    Millennium Challenge Corporation — The evaluation seeks to establish evidence on the possible effects of an intervention designed to modernize public procurement: effects on cost savings, performance...

  9. Public Procurement and Innovation

    DEFF Research Database (Denmark)

    Rolfstam, Max

    be understood as a special case of innovation, where social processes – and consequently the institutions governing these social processes – need to be considered. This book contributes to our understanding with a detailed institutional analysis of the public procurement of innovation.......Max Rolfstam examines the increasing emphasis on public procurement as a means to stimulate innovation and the theoretical implications of this policy development. While ‘regular’ public procurement may be regarded as the outcome of anonymous market processes, public procurement of innovation must...

  10. Central Control and Automation Systems: A Management and Procurement Handbook. Second Edition.

    Science.gov (United States)

    Association of Physical Plant Administrators of Universities and Colleges, Washington, DC.

    It is presumed that those reading this book presently own and operate a central control and monitoring system (CCMS) or plan to implement one in the near future. One objective of this workbook is to present useful knowledge from case histories of members of the Association of Physical Plant Administrators of Universities and Colleges as well as…

  11. CFM technologies for space transportation: Multipurpose hydrogen testbed system definition and tank procurement

    Science.gov (United States)

    Fox, E. C.; Kiefel, E. R.; Mcintosh, G. L.; Sharpe, J. B.; Sheahan, D. R.; Wakefield, M. E.

    1993-01-01

    The development of a test bed tank and system for evaluating cryogenic fluid management technologies in a simulated upper stage liquid hydrogen tank is covered. The tank is 10 ft long and is 10 ft in diameter, and is an ASME certified tank constructed of 5083 aluminum. The tank is insulated with a combination of sprayed on foam insulation, covered by 45 layers of double aluminized mylar separated by dacron net. The mylar is applied by a continuous wrap system adapted from commercial applications, and incorporates variable spacing between the mylar to provide more space between those layers having a high delta temperature, which minimizes heat leak. It also incorporates a unique venting system which uses fewer large holes in the mylar rather than the multitude of small holes used conventionally. This significantly reduces radiation heat transfer. The test bed consists of an existing vacuum chamber at MSFC, the test bed tank and its thermal control system, and a thermal shroud (which may be heated) surrounding the tank. Provisions are made in the tank and chamber for inclusion of a variety of cryogenic fluid management experiments.

  12. Procurement with Specialized Firms

    NARCIS (Netherlands)

    Boone, J.; Schottmuller, C.

    2011-01-01

    This paper analyzes optimal procurement mechanisms in a setting where the procurement agency has incomplete information concerning the firms’ cost functions and cares about quality as well as price. Low type firms are cheaper than high type firms in providing low quality but more expensive when

  13. Procurement with specialized firms

    NARCIS (Netherlands)

    Boone, Jan; Schottmuller, C.

    2016-01-01

    We analyze optimal procurement mechanisms when firms are specialized. The procurement agency has incomplete information concerning the firms' cost functions and values high quality as well as low price. Lower type firms are cheaper (more expensive) than higher type firms when providing low (high)

  14. Evolving Procurement Organizations

    DEFF Research Database (Denmark)

    Bals, Lydia; Laiho, Aki; Laine, Jari

    Procurement has to find further levers and advance its contribution to corporate goals continuously. This places pressure on its organization in order to facilitate its performance. Therefore, Procurement organizations constantly have to evolve in order to match these demands. A conceptual model...... is presented and results of a first case study discussed. The findings highlight the importance of taking a contingency perspective on Procurement organization, understanding the internal and internal contingency factors. From a theoretical perspective, it opens up insights that can be furthermore leveraged...... in future studies in the fields of hybrid procurement organizations, global sourcing organizations as well as international procurement offices (IPOs). From a practical standpoint, an assessment of external and internal contingencies provides the opportunity to consciously match organization to its...

  15. 41 CFR 101-26.602-1 - Procurement of lubricating oils, greases, and gear lubricants.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement of... Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.6-Procurement Sources Other Than GSA § 101...

  16. Lung involvement in systemic connective tissue diseases

    Directory of Open Access Journals (Sweden)

    Plavec Goran

    2008-01-01

    Full Text Available Background/Aim. Systemic connective tissue diseases (SCTD are chronic inflammatory autoimmune disorders of unknown cause that can involve different organs and systems. Their course and prognosis are different. All of them can, more or less, involve the respiratory system. The aim of this study was to find out the frequency of respiratory symptoms, lung function disorders, radiography and high-resolution computerized tomography (HRCT abnormalities, and their correlation with the duration of the disease and the applied treatment. Methods. In 47 non-randomized consecutive patients standard chest radiography, HRCT, and lung function tests were done. Results. Hypoxemia was present in nine of the patients with respiratory symptoms (20%. In all of them chest radiography was normal. In five of these patients lung fibrosis was established using HRCT. Half of all the patients with SCTD had symptoms of lung involvement. Lung function tests disorders of various degrees were found in 40% of the patients. The outcome and the degree of lung function disorders were neither in correlation with the duration of SCTD nor with therapy used (p > 0.05 Spearmans Ro. Conclusion. Pulmonary fibrosis occurs in about 10% of the patients with SCTD, and possibly not due to the applied treatment regimens. Hypoxemia could be a sing of existing pulmonary fibrosis in the absence of disorders on standard chest radiography.

  17. Donor selection criteria and procurement

    International Nuclear Information System (INIS)

    Agcaoili, N.R.

    1999-01-01

    Donor selection is one of the most important aspects of tissue banking practice. Without a good donor selection criteria, the results of any effort of trying to preserve tissues will have disastrous outcome for the recipient of these tissues. While with a very good and strict donor selection the Tissue Bank can guarantee safe and effective tissue allografts. There are significant aspects in the history and physical examination of the donor that must be emphasized. A donor exclusion criteria has also been formulated together with a list of all the needed laboratory examinations to eliminate possible diseases that may be transferred from the donor. The methods of procurement of tissue allografts from living and cadaver donors will be described. The limitations and advantages of each will be taken.There are also special restrictions that are important in the practice of removing the tissues from the donors. All the necessary equipment should be ready and the potential risk on the personnel should be known to all doing Tissue Banking

  18. Conflicts in Public Procurement

    Directory of Open Access Journals (Sweden)

    Helena Lindskog

    2013-01-01

    Full Text Available During the last couple of years, there has been a tendency to include more and more political goals into public procurements, such as environmental and societal considerations. This can result in higher prices paid by the public sector compared with similar procurements in the private sector. The decision makers at local level are elected and should represent the interest of their communities and voters, which includes promoting regional/local companies and economic development. This task can sometimes get into conflict with public procurement law or the political goals of a central government. (original abstract

  19. Brexit and government procurement

    OpenAIRE

    Dawar, Kamala

    2017-01-01

    This briefing paper looks at some of the legal issues that will affect the UK’s public procurement laws and policies following Brexit. For, once the UK revokes the European Communities Act 1972, it will no longer be obligated to follow the EU Procurement Directives, nor will it be subject to the commitments the EU has signed up to on behalf of the UK in the WTO Government Procurement Agreement (GPA) and in Preferential Trade Agreements (PTAs). Additionally, under the Devolution Settlement of ...

  20. Croatia : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2005-01-01

    Based on the CPAR's analysis of the legislative framework, procurement practices, institutional capacity and the opportunity for corruption, the assessment found that the environment for conducting public procurement in Croatia is average. This report makes a series of recommendations designed to strengthen the public procurement environment of Croatia, including legislative reform, improving procurement procedures and practices, institutional reform, capacity building, and the development of...

  1. Fighting corruption in tactical procurement

    NARCIS (Netherlands)

    Obanda Wanyama, Peter

    2010-01-01

    Vast amount of public resources are spent on procurement. Effective public procurement yields additional budget space, hence it ought to be conducted with due diligence. However, public procurement most especially tactical procurement in local governments in Uganda is vulnerable to corruption. In

  2. Summary of development and recommendations for a quality assurance program for the procurement and manufacture of urban mass transit operating equipment and systems

    Science.gov (United States)

    Witkin, S. A.

    1976-01-01

    A viable quality program for the urban mass transit industry, and a management approach to ensure compliance with the program are outlined. Included are: (1) a set of guidelines for quality assurance to be imposed on transit authorities, and a management approach to ensure compliance with them; (2) a management approach to be used by the transit authorities (properties) for assuring compliance with the QA guidelines; and (3) quality assurance guidelines to be imposed by properties and umta for procurement of hardware and systems.

  3. Towards the procurement of the ITER divertor

    International Nuclear Information System (INIS)

    Merola, M.; Tivey, R.; Martin, A.; Pick, M.

    2006-01-01

    divertor. All the seven ITER PTs are involved in the procurement of the divertor diagnostic systems. The engineering implications of integrating the required diagnostics in the divertor design are being assessed. This paper presents an organisational overview and the future procurement plans for ITER. Its aim is to show the work that will need to be carried out until the start of the divertor procurement. (author)

  4. A procurement decision support mechanism on multi-attribute fuzzy-interval auctions

    DEFF Research Database (Denmark)

    Franco de los Ríos, Camilo; Hougaard, Jens Leth; Nielsen, Kurt

    2016-01-01

    Procurement systems are the basis for assuring efficiency and fairness in organizations. Consequently, the development of procurement systems faces an ongoing challenge in designing trading systems that facilitate transparent competition on both price and multiple attributes, as well as ensuring...

  5. Evolving Procurement Organizations

    DEFF Research Database (Denmark)

    Bals, Lydia; Laine, Jari; Mugurusi, Godfrey

    Procurement has to find further levers and advance its contribution to corporate goals continuously. This places pressure on its organization in order to facilitate its performance. Therefore, procurement organizations constantly have to evolve in order to match these demands. A conceptual model...... and external contingency factors and having a more detailed look at the structural dimensions chosen, beyond the well-known characteristics of centralization, formalization, participation, specialization, standardization and size. From a theoretical perspective, it opens up insights that can be leveraged...

  6. Sustainable Bridge Infrastructure Procurement

    DEFF Research Database (Denmark)

    Safi, Mohammed; Du, Guangli; Simonsson, Peter

    2016-01-01

    The lack of a flexible but systematic approach for integrating lifecycle aspects into bridge investment decisions is a major obstacle hindering the procurement of sustainable bridge infrastructures. This paper addresses this obstacle by introducing a holistic approach that agencies could use...... to procure the most “sustainable” (lifecycle-efficient) bridge through a fair design-build (D-B) tendering process, considering all the main aspects: life-cycle cost (LCC), service life-span, aesthetic demands and environmental impacts (LCA)....

  7. Small Business Procurement Event

    Science.gov (United States)

    2014-08-13

    Small Business Procurement Event 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Department of the Navy,Office of Small Business Programs,720 Kennon...distribution unlimited 13. SUPPLEMENTARY NOTES NDIA 27th Navy Gold Coast Small Business Procurement Event, 12-13 Aug 2014, San Diego, CA. 14. ABSTRACT

  8. Fighting corruption in tactical procurement

    OpenAIRE

    Obanda Wanyama, Peter

    2010-01-01

    Vast amount of public resources are spent on procurement. Effective public procurement yields additional budget space, hence it ought to be conducted with due diligence. However, public procurement most especially tactical procurement in local governments in Uganda is vulnerable to corruption. In this thesis we analyze how tactical procurement can be managed to fight corruption and promote integrity in the decentralized context in local governments in Uganda. Specifically, we identify the mos...

  9. Considerations regarding procurement activities in institutions of local authority

    OpenAIRE

    Mãdãlina ALBU

    2013-01-01

    Objectives which they propose a public authority requires, among others, providing the necessary resources, including the material occupy a large proportion. This is done through the public procurement system. The procurement is part of the legal and economic reality of the Romanian society and covers all rules and actions on public spending and the application launched by public bodies meets the proposed offer of an operator. This paper presents an analysis of the public procurement system i...

  10. Tissue

    Directory of Open Access Journals (Sweden)

    David Morrissey

    2012-01-01

    Full Text Available Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based transgene expression in murine quadriceps in vivo was examined. Temporal control was assessed using a doxycycline-inducible system. An ex vivo model was developed and optimised using murine tissue, and applied in ex vivo human tissue. Results. In vivo plasmid-based transgene expression did not silence in murine muscle, unlike in liver. Although maximum luciferase expression was higher in muscle with adenoviral delivery compared with plasmid, expression reduced over time. The inducible promoter cassette successfully regulated gene expression with maximum levels a factor of 11 greater than baseline. Expression was re-induced to a similar level on a temporal basis. Luciferase expression was readily detected ex vivo in human muscle and tendon. Conclusions. Plasmid constructs resulted in long-term in vivo gene expression in skeletal muscle, in a controllable fashion utilising an inducible promoter in combination with oral agents. Successful plasmid gene transfection in human ex vivo mesenchymal tissue was demonstrated for the first time.

  11. ANALYSIS OF THE FOREIGN GOVERNMENT AND CORPORATE PROCUREMENT MANAGEMENT EXPERIENCE

    Directory of Open Access Journals (Sweden)

    Vladimir Vladimirovich Savchenko

    2016-01-01

    Full Text Available This article presents a synthesis of the experience of foreign government and corporate procurement management. Set out key aspects of the organization of procurement for government and corporate needs, disclosed issues of centralization and decentralization of procurement, as well as given clarifi cation of the concept of "procurement management system" and structured the main elements that make up this system. The purpose / goal. The purpose of the work is to study the nature and characteristics of the functioning of government and corporate experience in procurement management, identifying problems and prospects of its development. Methodology. To perform this work were used legal, comparative and statistical analysis methods. Results. As part of the presentation of the present article the author has examined the nature, objectives and stages of public and corporate procurement management.

  12. IEA Task 24 Solar procurement 2000

    Energy Technology Data Exchange (ETDEWEB)

    Ellehauge, K.; Oestergaard, I. [Teknologisk Institut, Taastrup. SolEnergiCentret (Denmark); Gramkow, L. [Esbensen, Copenhagen (Denmark)

    2002-04-01

    The objective of the project is to develop and improve large procurements of solar heating systems in order to be able to place large orders with manufacturers and suppliers. The project work will be carried out as an international co-operation under IEA Task 24 with the title 'Solar Procurement'. By co-ordinating the effort between the 4-6 participating countries, the objective is to purchase at least 10,000 solar heating systems, of this amount 1,000-2,000 in Denmark. Such large orders make it possible for manufacturers and suppliers to deliver systems considerably cheaper, and it will be possible to develop systems for given specifications on output and efficiency. These co-ordinated large orders are expected to improve the price/efficiency conditions by up to 50%. The so called 'procurement process' (co-ordinated international procurement based on goal-oriented system development in co-operation between customers and suppliers/manufacturers) will in the project be followed up by information/marketing, education, financing schemes, service schemes, quality assurance and technical support. The project is divided into two main areas (IEA subtasks). 1: 'Procurement and Marketing' and 2: 'Creation of Tools'. Denmark has been requested to be the project manager of subtask 2, 'Creation of Tools'. (EHS)

  13. IEA Task 24 Solar procurement 2000

    International Nuclear Information System (INIS)

    Ellehauge, K.; Oestergaard, I.; Gramkow, L.

    2002-04-01

    The objective of the project is to develop and improve large procurements of solar heating systems in order to be able to place large orders with manufacturers and suppliers. The project work will be carried out as an international co-operation under IEA Task 24 with the title 'Solar Procurement'. By co-ordinating the effort between the 4-6 participating countries, the objective is to purchase at least 10,000 solar heating systems, of this amount 1,000-2,000 in Denmark. Such large orders make it possible for manufacturers and suppliers to deliver systems considerably cheaper, and it will be possible to develop systems for given specifications on output and efficiency. These co-ordinated large orders are expected to improve the price/efficiency conditions by up to 50%. The so called 'procurement process' (co-ordinated international procurement based on goal-oriented system development in co-operation between customers and suppliers/manufacturers) will in the project be followed up by information/marketing, education, financing schemes, service schemes, quality assurance and technical support. The project is divided into two main areas (IEA subtasks). 1: 'Procurement and Marketing' and 2: 'Creation of Tools'. Denmark has been requested to be the project manager of subtask 2, 'Creation of Tools'. (EHS)

  14. Statistical Studies of Non-price Competition in the Structure of Public Procurement in the Russian Federation

    OpenAIRE

    Svetlana Aleksandrovna Sergeeva; Alexander Alexandrovich Arionchik

    2016-01-01

    The principle of securing competition is one of the basic principles of the contract system in public procurement in the Russian Federation. The law on the contract system in procurement stipulates that the contract system in procurement is aimed at creating equal conditions to ensure competition between the parties to procurement. An important aspect is that the competition for procurement should be based on compliance with the principle of fair price and non-price competition. The purpose o...

  15. Near Infrared Spectroscopy Systems for Tissue Oximetry

    DEFF Research Database (Denmark)

    Petersen, Søren Dahl

    for other medical applications. The tissue oximeters are realised by incorporation of pn-diodes into the silicon in order to form arrays of infrared detectors. These arrays can then be used for spatially resolved spectroscopy measurements, with the targeted end user being prematurely born infant children...

  16. Tissue doses in X-ray examinations of osteoarticular system

    International Nuclear Information System (INIS)

    Rabkin, I.Kh.; Stavitskij, R.V.; Blinov, N.N.; Vasil'ev, Yu.D.

    1985-01-01

    The X-ray method in diagnosis of the osteoarticular system disease is described. Problems on tissue dose distribution in X-ray examinations of a skeleton, a skull, humeral articulation, cervical, thoracic and lumbar vertebrae, hip joint, hipbones are considered. The values of specific tissue doses in roentgenography of the osteoarticular system are given

  17. Procurement and Supply Management System for MDR-TB in Nigeria: Are the Early Warning Targets for Drug Stock Outs and Over Stock of Drugs Being Achieved?

    Science.gov (United States)

    Jatau, Bolajoko; Avong, Yohanna; Ogundahunsi, Olumide; Shah, Safieh; Tayler Smith, Katherine; Van den Bergh, Rafael; Zachariah, Rony; van Griensven, Johan; Ekong, Ernest; Dakum, Patrick

    2015-01-01

    The World Health Organisation (WHO) introduced the twelve early warning indicators for monitoring and evaluating drug Procurement and Supply management (PSM) systems, intended to prevent drug stock-outs and overstocking. Nigeria--one of the high Multi Drug Resistant Tuberculosis (MDR-TB) burden countries, scaled-up treatment in 2012 with the concurrent implementation of a PSM system. We evaluated how well this system functioned using the WHO indicators, including all seven MDR-TB treatment centres in the country that were functional throughout 2013. The quantity of MDR-TB drugs ordered for 2013 matched the annual forecast and all central orders placed during the year were delivered in full and on time. Drug consumption was 81%-106% of the quantity allocated for routine consumption. Timely submission of complete inventory reports ranged from 86-100%, late submissions being 5-15 days late. Forty to 71% of treatment centres placed a drug order when stock was below the minimum level of three months. The proportion of drug orders received at the treatment centres in full and on time ranged from 29-80%, late orders being 1-19 days late. The PSM was found to be performing well in terms of forecasting and procurement of MDR-TB drugs, but there were shortcomings in drug distribution, reporting at treatment centre level and in drug order placements. Despite these gaps, there were no stock outs. These findings indicate that where it matters most, namely ensuring that no drug stock outs affect patient management, the PSM system is effective. Addressing the observed shortcomings will help to strengthen the existing PSM system in anticipation of a growing MDR-TB case burden in the country.

  18. Data feature: Fuel procurement

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    This document is a review of the effect of fuel costs on the procurement strategies of a utility and a conjecture that the same strategies may have an effect on the price of fuel. Factors affecting fuel costs are reviewed, and a number of procurement strategies taken to trim fuel costs are reviewed. The major trend is away from long-term enrichment contracts and into such strategies as: (1) Spot market purchases, (2) Inventory reduction, (3) Purchase of CIS material, and (4) Market-related contracts instead of base-escalated contracts

  19. 48 CFR 1323.404-70 - DOC affirmative procurement program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false DOC affirmative procurement program. 1323.404-70 Section 1323.404-70 Federal Acquisition Regulations System DEPARTMENT OF..., OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Use of Recovered Materials 1323.404-70 DOC affirmative procurement...

  20. Malawi : Country Procurement Assessment Report, Volume 3. Executive Summary

    OpenAIRE

    World Bank

    2004-01-01

    The Malawi Country Procurement Assessment Report is a joint undertaking between the Malawi Government and the World Bank to analyze the country procurement system and recommend appropriate actions to improve the efficiency, economy and transparency of the system. This report is divided into (a) an Executive Summary, (b) Main Report on Findings and Recommendations, and (c) Annexes. Since th...

  1. Malawi : Country Procurement Assessment Report, Volume 2. Details and Annexes

    OpenAIRE

    World Bank

    2004-01-01

    The Malawi Country Procurement Assessment Report is a joint undertaking between the Malawi Government and the World Bank to analyze the country procurement system and recommend appropriate actions to improve the efficiency, economy and transparency of the system. This report is divided into (a) an Executive Summary, (b) Main Report on Findings and Recommendations, and (c) Annexes. Since th...

  2. 48 CFR 2901.603-72 - Administrative procurement management reviews.

    Science.gov (United States)

    2010-10-01

    ... Authority, and Responsibilities 2901.603-72 Administrative procurement management reviews. (a) The Senior... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administrative procurement management reviews. 2901.603-72 Section 2901.603-72 Federal Acquisition Regulations System DEPARTMENT OF...

  3. CORRELATES OF PROCUREMENT PERFORMANCE OF ...

    African Journals Online (AJOL)

    Osondu

    2013-02-22

    Feb 22, 2013 ... Purpose of this study is to investigate if procurement challenges, contractual procedures, designer's experience ... Design and Build, Project Management, Direct. Labour and ..... Government Procurement Performance in.

  4. Optimal Coordinated Strategy Analysis for the Procurement Logistics of a Steel Group

    Directory of Open Access Journals (Sweden)

    Lianbo Deng

    2014-01-01

    Full Text Available This paper focuses on the optimization of an internal coordinated procurement logistics system in a steel group and the decision on the coordinated procurement strategy by minimizing the logistics costs. Considering the coordinated procurement strategy and the procurement logistics costs, the aim of the optimization model was to maximize the degree of quality satisfaction and to minimize the procurement logistics costs. The model was transformed into a single-objective model and solved using a simulated annealing algorithm. In the algorithm, the supplier of each subsidiary was selected according to the evaluation result for independent procurement. Finally, the effect of different parameters on the coordinated procurement strategy was analysed. The results showed that the coordinated strategy can clearly save procurement costs; that the strategy appears to be more cooperative when the quality requirement is not stricter; and that the coordinated costs have a strong effect on the coordinated procurement strategy.

  5. 41 CFR 101-26.602-5 - Procurement of natural gas from the wellhead and other supply sources.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement of natural... Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.6-Procurement Sources Other Than GSA § 101...

  6. 41 CFR 101-26.505-3 - Requests to procure similar items from sources other than GSA supply sources.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Requests to procure... Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26...

  7. Slovakia : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2001-01-01

    This update of the 1995 CPAR is based on the September 1999 PPA and the findings of the Bank CPAR mission to Slovakia in November 1999. The 1999 Public Procurement Act (PPA) is an improvement upon the previous PPAs in some respects, including the creation of an OPP, more detailed and clear procurement procedures, accreditation of procurement professionals, introduction of the Public Procu...

  8. Tanzania : Country Procurement Assessment Report

    OpenAIRE

    World Bank

    2003-01-01

    This Country Procurement Assessment Report (CPAR)intends to determine the compatibility of national procurement law, and practices, with the principles of economy, and with international procurement practices. This CPAR, the second of its kind in Tanzania, looks at the legislative framework, the performance of regulatory functions, the enforcement regime, and the capacity of public sector ...

  9. OAS :: Accountability :: Procurement

    Science.gov (United States)

    OAS, including its organizational structure, each organizational unit's staffing, vacant posts, and a list of procurement notices for formal bids, links to the performance contract and travel control Performance Contract reports from January 2013 to June 2017 may be found.) Travel Information and Control

  10. Procurement Sustainable Building Practice

    NARCIS (Netherlands)

    Schmid, P.

    1998-01-01

    Two aspects will be stressed in the frame of this topic: The Procurement Aspects and the Aspects of Conflict and Dispute Resolution. The Right for Environment - to introduce the following aspects - is not only the consequence of care-taking for Nature as an admirable phenomenon, but also as a source

  11. Scoping Aerospace: Tracking Federal Procurement and R&D Spending in the Aerospace Sector

    National Research Council Canada - National Science Library

    Hogan, Thor; Fossum, Donna; Johnson, Dana J; Painter, Lawrence S

    2005-01-01

    .... The study provides a detailed examination of the Federal Procurement Data System (FPDS), with the specific purpose of tracking all government aerospace procurement and research and development (R AND D...

  12. Controlled procurement for nuclear power plants

    International Nuclear Information System (INIS)

    MacFarlane, I.S.

    1985-01-01

    A method is presented for establishing a controlled materials management system that facilitates materials procurement at nuclear power plants. This method is based on the determination of informational data requirements, appropriate input and approvals, and extent of administrative controls. Implementation of the techniques described herein will ensure that the accuracy of important procurement information is not compromised by unauthorized initial input or changes and/or failure to maintain the information. Needed material can thus be ordered through the materials management system with a high degree of confidence that the correct items are ordered, with minimal internal lead time and minimum delays during the receiving process

  13. 25 CFR 900.49 - What procurement standards apply to subcontracts?

    Science.gov (United States)

    2010-04-01

    ... ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Procurement Management System Standards § 900.49 What procurement standards apply to subcontracts? Each subcontract entered into under the... 25 Indians 2 2010-04-01 2010-04-01 false What procurement standards apply to subcontracts? 900.49...

  14. Thrombomodulin Expression in Tissues From Dogs With Systemic Inflammatory Disease.

    Science.gov (United States)

    Kim, S D; Baker, P; DeLay, J; Wood, R D

    2016-07-01

    Thrombomodulin (TM) is a membrane glycoprotein expressed on endothelial cells, which plays a major role in the protein C anticoagulation pathway. In people with inflammation, TM expression can be down-regulated on endothelial cells and a soluble form released into circulation, resulting in increased risk of thrombosis and disseminated intravascular coagulation. TM is present in dogs; however, there has been minimal investigation of its expression in canine tissues, and the effects of inflammation on TM expression in canine tissues have not been investigated. The objective of this study was to evaluate endothelial TM expression in tissues from dogs with systemic inflammatory diseases. A retrospective evaluation of tissue samples of lung, spleen, and liver from dogs with and without systemic inflammatory diseases was performed using immunohistochemistry (IHC) and a modified manual IHC scoring system. TM expression was significantly reduced in all examined tissues in dogs diagnosed with septic peritonitis or acute pancreatitis. © The Author(s) 2016.

  15. (De)Centralization of Public Procurement at the Local Level in the EU

    OpenAIRE

    Boštjan BREZOVNIK; Žan Jan OPLOTNIK; Borut VOJINOVIĆ

    2015-01-01

    The so-called decentralization of public procurement in EU Member States is accepted as the most suitable design of the public procurement system, often justifi ed by greater economic effi ciency and by the possibility of boosting the development of small and medium-sized enterprises, which act on the public procurement market as providers of goods, services and works. Despite the existence of highly decentralized public procurement systems which refl ect the decentralization of administrativ...

  16. 75 FR 41449 - Procurement List Additions and Deletion

    Science.gov (United States)

    2010-07-16

    ... Customs and Border Protection, Office of Procurement, Washington, DC Service Type/Locations: Laundry.../Locations: Laundry Service, Naval Hospital System, 2800 Child Street, Jacksonville, FL NPA: GINFL Services...: Additions to and deletion from the Procurement List. SUMMARY: This action adds products and services to the...

  17. Microfluidic systems for stem cell-based neural tissue engineering.

    Science.gov (United States)

    Karimi, Mahdi; Bahrami, Sajad; Mirshekari, Hamed; Basri, Seyed Masoud Moosavi; Nik, Amirala Bakhshian; Aref, Amir R; Akbari, Mohsen; Hamblin, Michael R

    2016-07-05

    Neural tissue engineering aims at developing novel approaches for the treatment of diseases of the nervous system, by providing a permissive environment for the growth and differentiation of neural cells. Three-dimensional (3D) cell culture systems provide a closer biomimetic environment, and promote better cell differentiation and improved cell function, than could be achieved by conventional two-dimensional (2D) culture systems. With the recent advances in the discovery and introduction of different types of stem cells for tissue engineering, microfluidic platforms have provided an improved microenvironment for the 3D-culture of stem cells. Microfluidic systems can provide more precise control over the spatiotemporal distribution of chemical and physical cues at the cellular level compared to traditional systems. Various microsystems have been designed and fabricated for the purpose of neural tissue engineering. Enhanced neural migration and differentiation, and monitoring of these processes, as well as understanding the behavior of stem cells and their microenvironment have been obtained through application of different microfluidic-based stem cell culture and tissue engineering techniques. As the technology advances it may be possible to construct a "brain-on-a-chip". In this review, we describe the basics of stem cells and tissue engineering as well as microfluidics-based tissue engineering approaches. We review recent testing of various microfluidic approaches for stem cell-based neural tissue engineering.

  18. Spare parts classification and procurement program

    International Nuclear Information System (INIS)

    Adlon, K.L.; Hassaballa, M.M.

    1986-01-01

    The cost benefits have been demonstrated for an integrated program, which is currently being implemented for two PWR stations with two 1100-MW units each. The component classification efforts reduced the number of safety-related components in several systems. Furthermore, the knowledge of the component specific function has contributed to the reduction of many safety-related parts per component, in addition to ensuring the procurement of parts to the correct safety level. The use of qualified commercial grade parts and components with their lower cost and reasonable procurement lead time compared to their 10 CFR 21 counterparts has a pronounced economic effect on the utility balance sheets

  19. Vascularized Composite Allografts: Procurement, Allocation, and Implementation.

    Science.gov (United States)

    Rahmel, Axel

    Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as 'organs'. In this review, key aspects of VCA procurement are discussed, with a special focus on interaction with the procurement of classical solid organs. In addition, options for a matching and allocation system that ensures VCA donor organs are allocated to the best-suited recipients are looked at. Finally, the different steps needed to promote VCA transplantation in society in general and in the medical community in particular are highlighted.

  20. Sustainable Procurement in the United Nations

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Costa, Nives

    2011-01-01

    are highly contested among UN procurement officers and member states. However, so far the debate has mostly been based on assumptions about how the implementation of SP might affect developing country stakeholders. In fact, very few academic studies have been made of the economic, social and environmental......This paper deals with the integration of economic, social and environmental criteria into the purchasing practices of the United Nations (UN) system--also known as the UN engagement in sustainable procurement (SP). We argue that the debates about the pros and cons of the UN engaging in SP...

  1. PROCUREMENT AND CONTRACT MANAGEMENT

    CERN Multimedia

    Training & Development Group; Linda Orr-Easo; Tel. 72460; Nathalie Dumeaux; Tel. 78144

    2001-01-01

    We are pleased to announce the launch of a new training on: Procurement and Contract Management (This seminar will be run by CERN experts in French or in English) Level 1 The aim is to raise awareness of the key issues involved. Date : 8 June 2001 This level is open to everyone. Participants should register via our Web page as soon as possible. Level 2 To develop the skills needed to effectively manage contracts, from the Technical, Commercial and Legal aspects. Dates : Three days, Autumn 2001 This Level is open to those who are/will be more directly responsible for procurement and contract management. Participants should have followed Level 1. For a description of the seminar, please consult:   Level 1: http://training.web.cern.ch/Training/MANCO/P9798/9-cm_e.htm Level 2: http://training.web.cern.ch/Training/MANCO/P9798/9-cm2_e.htm

  2. Price competition in procurement

    International Nuclear Information System (INIS)

    Keisler, J.M.; Buehring, W.A.

    1996-07-01

    When creating a private market to provide a public good, government agencies can influence the market's competitive characteristics. Markets have predictable, but often counterintuitive, behaviors. To succeed in applying available controls, and thereby reduce future costs, agencies must understand the behavior of the market. A model has been constructed to examine some issues in establishing competition for a structure in which there are economies of scale and government is obligated to purchase a fixed total quantity of a good. This model is used to demonstrate a way to estimate the cost savings from several alternative plans for a buyer exploring competitive procurement. The results are not and cannot be accurate for budgeting purposes; rather, they indicate the approximate magnitude of changes in cost that would be associated with changes in the market structure within which procurement occurs

  3. Defense Primer: Procurement

    Science.gov (United States)

    2017-02-10

    Usually, incremental funding is used to mitigate peaks and valleys in annual budgets caused by the cost of one item significantly changing the...base defense budget . DOD uses these funds to buy several different types of materiel, including  new items easily recognizable as military...pursues a policy of full funding for procurement, meaning that the total estimated cost of each unit must be funded in the year it is budgeted . In a

  4. Procurement and participation opportunities

    International Nuclear Information System (INIS)

    Lovatt, D.

    1998-01-01

    The elements which drive the Sable Offshore Energy Project and its procurement processes were described. The project is privately financed, hence business practices must adhere to strict principles to be able to compete with alternative energy sources and to ensure success for all stakeholders including owners, contractors, suppliers and the business community. One of the objectives of the project is to adhere to the requirements of applicable legislation and not to compromise health, safety and environmental standards. To ensure this compliance by all concerned, the regulatory requirements are embedded in the contracting and procurement procedures. Details of the procurement cycle are described. A list of some of the successes that Nova Scotian companies have had in getting work on the project was provided as an illustration of the ingenuity and foresight of these companies to develop appropriate quality assurance and health, safety and environmental procedures, and to bring in the needed capacity and technology through the formation of joint ventures and alliances. The list of contracts represents more than 100 million dollars worth of work to date. 3 figs

  5. Microfluidic system for enhanced cardiac tissue formation

    Directory of Open Access Journals (Sweden)

    Busek Mathias

    2017-09-01

    Full Text Available Hereby a microfluidic system for cell cultivation is presented in which human pluripotent stem cell-derived cardiomyocytes were cultivated under perfusion. Besides micro-perfusion this system is also capable to produce well-defined oxygen contents, apply defined forces and has excellent imaging characteristics. Cardiomyocytes attach to the surface, start spontaneous beating and stay functional for up to 14 days under perfusion. The cell motion was subsequently analysed using an adapted video analysis script to calculate beating rate, beating direction and contraction or relaxation speed.

  6. E-government and e-business integration model in public procurement

    OpenAIRE

    Junevičius, Algis; Ereminaitė, Simona

    2011-01-01

    Public procurement is one of the most actual problems of economics and potential instrument of successful public policy, which can control money flows and manipulate the appearance of corruption opportunities. By 2010, all EU countries should have been installed electronic public procurement systems and at least 50 percent public procurement should have been made by this way. Thus for a membership of different countries' procurers is essential for EU and domestic economy of the Republic of Li...

  7. Persepsi Pengguna Layanan Pengadaan Barang dan Jasa pada Pemerintah Kota YOGYAKARTA terhadap Implementasi Sistem E Procurement

    OpenAIRE

    Nightisabha, Ita Akyuna; Suhardjanto, Djoko; Cahya, Bayu Tri

    2009-01-01

    This study aims to evaluate the implementation of electronic procurement of goods and services by the Government City of Yogyakarta, as an effort to create good governance especially in terms of procurement. This study compares the perceptions of user that consist of procurement committee and the providers of goods and services. Research location is in Layanan Pengadaan Secara Elektronik (LPSE) of Government City of Yogyakarta as a system developer with the sample of the procurement committee...

  8. Persepsi Pengguna Layanan Pengadaan Barang dan Jasa pada Pemerintah Kota Yogyakarta terhadap Implementasi Sistem E Procurement

    OpenAIRE

    Nightisabha, Ita Akyuna; Suhardjanto, Djoko; Cahya, Bayu Tri

    2011-01-01

    This study aims to evaluate the implementation of electronic procurement of goods and services by the Government City of Yogyakarta, as an effort to create good governance especially in terms of procurement. This study compares the perceptions of user that consist of procurement committee and the providers of goods and services. Research location is in Layanan Pengadaan Secara Elektronik (LPSE) of Government City of Yogyakarta as a system developer with the sample of the procurement committee...

  9. A rational procedure for the selection of appropriate procurement ...

    African Journals Online (AJOL)

    Construction work is procured via a number of systems, such as being Open and ... routes for construction projects as a means to enhance the quality of management ... systems to decision-making procedures in the construction industry.

  10. Multicriteria analysis in public procurement

    Directory of Open Access Journals (Sweden)

    Dejan T. Tošev

    2012-07-01

    Full Text Available The public procurement is one of the most important processes in modern company daily business. The quality of that process and its realization affect the overall company success and reputation. For that purpose, the management is obliged to prepare and carry out the procurement process carefully. The process is based on multicriteria tendering and the purpose of this paper is to present the analytical and hierarchical procurement methods in order to minimize failing in the selection and decision making process.

  11. Coverage of the WTO's Agreement on Government Procurement: Challenges of Integrating China and other Countries with a Large State Sector into the Global Trading System

    OpenAIRE

    Wang Ping

    2007-01-01

    The WTO's plurilateral Agreement on Government Procurement (GPA) is a significant WTO instrument to develop disciplines regulating government procurement. A recent major review of the GPA has led to a revised text, likely to enter into force in 2007. In the meanwhile, China, a country with a large state sector, has promised to initiate GPA accession negotiations by the end of 2007.The article provides a critical assessment of the extent to which the recent review of the coverage of the GPA ha...

  12. Promoting tissue regeneration by modulating the immune system.

    Science.gov (United States)

    Julier, Ziad; Park, Anthony J; Briquez, Priscilla S; Martino, Mikaël M

    2017-04-15

    The immune system plays a central role in tissue repair and regeneration. Indeed, the immune response to tissue injury is crucial in determining the speed and the outcome of the healing process, including the extent of scarring and the restoration of organ function. Therefore, controlling immune components via biomaterials and drug delivery systems is becoming an attractive approach in regenerative medicine, since therapies based on stem cells and growth factors have not yet proven to be broadly effective in the clinic. To integrate the immune system into regenerative strategies, one of the first challenges is to understand the precise functions of the different immune components during the tissue healing process. While remarkable progress has been made, the immune mechanisms involved are still elusive, and there is indication for both negative and positive roles depending on the tissue type or organ and life stage. It is well recognized that the innate immune response comprising danger signals, neutrophils and macrophages modulates tissue healing. In addition, it is becoming evident that the adaptive immune response, in particular T cell subset activities, plays a critical role. In this review, we first present an overview of the basic immune mechanisms involved in tissue repair and regeneration. Then, we highlight various approaches based on biomaterials and drug delivery systems that aim at modulating these mechanisms to limit fibrosis and promote regeneration. We propose that the next generation of regenerative therapies may evolve from typical biomaterial-, stem cell-, or growth factor-centric approaches to an immune-centric approach. Most regenerative strategies have not yet proven to be safe or reasonably efficient in the clinic. In addition to stem cells and growth factors, the immune system plays a crucial role in the tissue healing process. Here, we propose that controlling the immune-mediated mechanisms of tissue repair and regeneration may support

  13. Traditional Procurement is too Slow

    Directory of Open Access Journals (Sweden)

    Ann Kong

    2012-11-01

    Full Text Available This paper reports on an exploratory interview survey of construction project participants aimed at identifying the reasons for the decrease in use of the traditional, lump-sum, procurement system in Malaysia. The results show that most people believe it is too slow. This appears to be in part due to the contiguous nature of the various phase and stages of the process and especially the separation of the design and construction phases. The delays caused by disputes between the various parties are also seen as a contributory factor - the most prominent cause being the frequency of variations, with design and scope changes being a particular source of discontent. It is concluded that an up scaling of the whole of the time related reward/penalty system may be the most appropriate measure for the practice in future.

  14. Advances in polymeric systems for tissue engineering and biomedical applications.

    Science.gov (United States)

    Ravichandran, Rajeswari; Sundarrajan, Subramanian; Venugopal, Jayarama Reddy; Mukherjee, Shayanti; Ramakrishna, Seeram

    2012-03-01

    The characteristics of tissue engineered scaffolds are major concerns in the quest to fabricate ideal scaffolds for tissue engineering applications. The polymer scaffolds employed for tissue engineering applications should possess multifunctional properties such as biocompatibility, biodegradability and favorable mechanical properties as it comes in direct contact with the body fluids in vivo. Additionally, the polymer system should also possess biomimetic architecture and should support stem cell adhesion, proliferation and differentiation. As the progress in polymer technology continues, polymeric biomaterials have taken characteristics more closely related to that desired for tissue engineering and clinical needs. Stimuli responsive polymers also termed as smart biomaterials respond to stimuli such as pH, temperature, enzyme, antigen, glucose and electrical stimuli that are inherently present in living systems. This review highlights the exciting advancements in these polymeric systems that relate to biological and tissue engineering applications. Additionally, several aspects of technology namely scaffold fabrication methods and surface modifications to confer biological functionality to the polymers have also been discussed. The ultimate objective is to emphasize on these underutilized adaptive behaviors of the polymers so that novel applications and new generations of smart polymeric materials can be realized for biomedical and tissue engineering applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. How is service procurement different from goods procurement? Exploring ex ante costs and ex post problems in IT procurement

    NARCIS (Netherlands)

    Wynstra, Finn; Rooks, Gerrit; Snijders, Chris

    2018-01-01

    Several studies suggest that, in practice, service procurement is more challenging than goods procurement. The underlying but largely implicit argument is that the procurement process for services involves higher buyer uncertainty and therefore requires extra efforts to mitigate this uncertainty.

  16. Procurement of medical equipment in Sweden

    Directory of Open Access Journals (Sweden)

    Heikki Terio

    2010-02-01

    Full Text Available In many hospitals in Sweden the importance of technology management is already accepted and accepted since the hospital managements have recognised that technology is an integral part of all major policy and planning decisions. Today’s medical devices are technically complex and sometimes a system of interacting devices is required to achieve the desired clinical function. If the hospitals want to use the latest, modern technology, then they need to make substantial investments in both equipment and competence. Complex technology, large investments and need of highly qualii ed personnel to handle the medical devices are factors that indicate a need of well-dei ned procurement process as an essential part of the total health technology management system that should be used in a hospital. In such a procurement process, carefully prepared planning of technology investments can reduce the running costs and costs for maintenance substantially. In addition, a well-dei ned procurement process contributes to increase the patient safety. In Karolinska University Hospital goods and services are purchased for more than 20% of the hospital’s €1.2 billion turnover. It is therefore very important that the procurement is carried out ef ectively.

  17. Procurement Sustainability Tensions

    DEFF Research Database (Denmark)

    Fayezi, Sajad; Zomorrodi, Maryam; Bals, Lydia

    2018-01-01

    as stakeholder and institutional theory. Design/methodology/approach: The authors use a multiple case study approach. Data are collected through multiple interviews and archival data from eight case companies in Australia. Findings: The authors identify supply chain and company procurement sustainability...... of institutional distance, can characterize the manifestation of PSTs. Practical implications: The findings are instrumental for managers to make informed decisions when dealing with PSTs, and they pave the way for paradoxical leadership given the increasing importance of simultaneous development and balancing...

  18. Optimal Acquisition and Production Policy for End-of-Life Engineering Machinery Recovering in a Joint Manufacturing/Remanufacturing System under Uncertainties in Procurement and Demand

    Directory of Open Access Journals (Sweden)

    Haolan Liao

    2017-02-01

    Full Text Available The intensive shortage of natural resources and the inchoate phase of automobile remanufacturing in a closed-loop supply chain (CLSC are driving people to take cyclic manufacturing seriously. Aiming at maximizing resource utilization and produce profits, we apply an optimizing mathematical analysis to the modeling of automobile engine remanufacturing in a joint manufacturing system, in which the quantity and quality of procurement, and the demand of the market, are both uncertain. The manufacturer can either produce new products with raw materials or remanufacture the returned product taken back from customers; the raw materials are bought from two suppliers with certain probabilities of disruption in the supply. The returned products are classified into different quality levels according to the testing results after sorting, by considering the remanufacture-up-to strategy we obtained the optimal remanufacturing ratio, then the manufacturing quantity and corresponding maximized total profit of this joint system are determined. We also investigated a real-life case of auto engine remanufacturing, comparing it with the theory of optimal remanufacturing policy, and the results indicate that a material savings of more than 45% and a cost improvement of more than 40% could be achieved when the optimal remanufacturing policy of our model is implemented.

  19. A Framework for Usability Evaluation in EHR Procurement.

    Science.gov (United States)

    Tyllinen, Mari; Kaipio, Johanna; Lääveri, Tinja

    2018-01-01

    Usability should be considered already by the procuring organizations when selecting future systems. In this paper, we present a framework for usability evaluation during electronic health record (EHR) system procurement. We describe the objectives of the evaluation, the procedure, selected usability attributes and the evaluation methods to measure them. We also present the emphasis usability had in the selection process. We do not elaborate on the details of the results, the application of methods or gathering of data. Instead we focus on the components of the framework to inform and give an example to other similar procurement projects.

  20. Risk Factors Influencing Construction Procurement Performance in Nigeria

    Directory of Open Access Journals (Sweden)

    Alhassan Dahiru

    2015-08-01

    Full Text Available One of the challenges facing construction procurement performance is the failure to determine the risk related factors limiting its success. These risk factors can cause a significant increase in the procurement cost leading to an increase in the overall project cost. The purpose of this study is to identify and evaluate the risk factors influencing construction procurement performance with a view to achieve the overall project performance. The objectives are to establish a relative significance index score for the most important risk factors limiting the procurement performance of the projects. A self administered questionnaire was employed to the construction industry professionals for responses. A total of 78 questionnaires were distributed to these professionals (architects, quantity surveyors, engineers, and contractors but 62 were returned and analyzed using influential index and later ranked in order of importance. Results of the analysis indicate a disparity in terms of ranking of the factors influencing construction procurement performance. Corruption related risk, conflict of interest, ineffective project technical feasibility, and lack of commitment to transparency were found to be the most significant factors limiting construction procurement performance. Communication barriers and unconfidential tender evaluation process were found to be the low weighted risk factors. The findings can serve as a supportive mechanism for risks management in public construction procurement management. Therefore, construction procurement personnel at all levels of government may find this study relevant, while improving construction procurement performance in the country. It is recommended that construction procurement system should be focused on risks related to corruption, conflict of interest, and effective technical feasibility for improving the overall project performance.

  1. TissueCypher™: A systems biology approach to anatomic pathology

    Directory of Open Access Journals (Sweden)

    Jeffrey W Prichard

    2015-01-01

    Full Text Available Background: Current histologic methods for diagnosis are limited by intra- and inter-observer variability. Immunohistochemistry (IHC methods are frequently used to assess biomarkers to aid diagnoses, however, IHC staining is variable and nonlinear and the manual interpretation is subjective. Furthermore, the biomarkers assessed clinically are typically biomarkers of epithelial cell processes. Tumors and premalignant tissues are not composed only of epithelial cells but are interacting systems of multiple cell types, including various stromal cell types that are involved in cancer development. The complex network of the tissue system highlights the need for a systems biology approach to anatomic pathology, in which quantification of system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making. Aims: Here, we describe a quantitative, multiplexed biomarker imaging approach termed TissueCypher™ that applies systems biology to anatomic pathology. Applications of TissueCypher™ in understanding the tissue system of Barrett's esophagus (BE and the potential use as an adjunctive tool in the diagnosis of BE are described. Patients and Methods: The TissueCypher™ Image Analysis Platform was used to assess 14 epithelial and stromal biomarkers with known diagnostic significance in BE in a set of BE biopsies with nondysplastic BE with reactive atypia (RA, n = 22 and Barrett's with high-grade dysplasia (HGD, n = 17. Biomarker and morphology features were extracted and evaluated in the confirmed BE HGD cases versus the nondysplastic BE cases with RA. Results: Multiple image analysis features derived from epithelial and stromal biomarkers, including immune biomarkers and morphology, showed significant differences between HGD and RA. Conclusions: The assessment of epithelial cell abnormalities combined with an assessment of cellular changes in the lamina propria may serve as an adjunct to conventional

  2. Industry activities to resolve utility procurement issues

    International Nuclear Information System (INIS)

    Rosch, F.

    1993-01-01

    There are several industry organizations which are active in assisting the utilities in their equipment procurement enhancement. They include the Nuclear Management Resources Council (NUMARC), the Electric Power Research Institute (EPRI), and the Nuclear Procurement Issues Committee (NUPIC). The products include the NUMARC Procurement Initiatives, EPRI procurement related guidelines and databases, and NUPIC joint audits and commercial grade surveys. The industry procurement activities and products are reviewed, and their use by utilities to enhance their procurement process is related. 1 fig

  3. Lives and choices, give and take: Altruism and organ procurement.

    Science.gov (United States)

    Thornton, Vicky

    2017-01-01

    In 2015, Wales introduced a deemed consent: soft opt-out system for organ procurement in order to address the chronic shortage of organs for transplant. Early statistical evidence suggests that this has had a positive impact on cadaveric organ donation. Such a system for procurement has previously been dismissed by the Organ Donation Taskforce, who suggested that opting out could potentially undermine the concept of donated organs as gifts and this could then negatively impact the number of organs offered for transplant. Considerable weight was placed upon the need to retain the altruistic gift element associated with an opt-in system. This article will consider the role of altruism in an organ procurement policy. A broad utilitarian approach will be taken when putting forward the arguments in favour of adopting a weak altruism position in a soft opt-out system for procurement with a combined registry.

  4. An investigation into the effectiveness of public entities’ procurement practices

    Directory of Open Access Journals (Sweden)

    Moitswadi Mofokeng

    2014-11-01

    Full Text Available The delivery of services through the procurement of goods and services requires proper strategic leadership and management processes. Inappropriate planning, under-spending of budgets and ineffective procurement form part of the root causes of poor service delivery, as this restricts the movement of resources to the right places. This study identified the leading procurement practices as: procurement strategy and leadership, the procurement process, human resource management, procurement information systems, supplier management and procurement performance management. These practices were then tested in public entities, mainly in Gauteng Province, South Africa, to determine the extent to which they are applied. The study found that there is a major divide between the perception of the level of application of the leading practices and actual implementation. Processes, skills, performance management, information technology (IT systems and supplier management are applied inadequately or inappropriately. Most entities thus show a poor understanding of customer needs and there seems to be a general lack of customer focus. The study highlighted the best practice areas in which public entities are able to focus their efforts to better achieve excellent customer service and thus service delivery.

  5. SECONDARY PULMONARY ARTERIAL HYPERTENSION IN SYSTEMIC DISEASES OF CONNECTIVE TISSUE

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2016-01-01

    Full Text Available Modern definition of pulmonary arterial hypertension (PAH as well as data on prevalence and incidence of secondary PAH in systemic disease of connective tissue is presented,  including data of USA, France and Scotland registers. The main chains of pathogenesis, classification approaches, clinical features and diagnostics are described. 

  6. SECONDARY PULMONARY ARTERIAL HYPERTENSION IN SYSTEMIC DISEASES OF CONNECTIVE TISSUE

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2009-01-01

    Full Text Available Modern definition of pulmonary arterial hypertension (PAH as well as data on prevalence and incidence of secondary PAH in systemic disease of connective tissue is presented,  including data of USA, France and Scotland registers. The main chains of pathogenesis, classification approaches, clinical features and diagnostics are described. 

  7. A photoacoustic tomography system for imaging of biological tissues

    International Nuclear Information System (INIS)

    Su Yixiong; Zhang Fan; Xu Kexin; Yao Jianquan; Wang, Ruikang K

    2005-01-01

    Non-invasive laser-induced photoacoustic tomography (PAT) is a promising imaging modality in the biomedical optical imaging field. This technology, based on the intrinsic optical properties of tissue and ultrasonic detection, overcomes the resolution disadvantage of pure-optical imaging caused by strong light scattering and the contrast and speckle disadvantages of pure ultrasonic imaging. Here, we report a PAT experimental system constructed in our laboratory. In our system, a Q-switched Nd : YAG pulse laser operated at 532 nm with a 8 ns pulse width is used to generate a photoacoustic signal. By using this system, the two-dimensional distribution of optical absorption in the tissue-mimicking phantom is reconstructed and has an excellent agreement with the original ones. The spatial resolution of the imaging system approaches 100 μm through about 4 cm of highly scattering medium

  8. The PAXgene(® tissue system preserves phosphoproteins in human tissue specimens and enables comprehensive protein biomarker research.

    Directory of Open Access Journals (Sweden)

    Sibylle Gündisch

    Full Text Available Precise quantitation of protein biomarkers in clinical tissue specimens is a prerequisite for accurate and effective diagnosis, prognosis, and personalized medicine. Although progress is being made, protein analysis from formalin-fixed and paraffin-embedded tissues is still challenging. In previous reports, we showed that the novel formalin-free tissue preservation technology, the PAXgene Tissue System, allows the extraction of intact and immunoreactive proteins from PAXgene-fixed and paraffin-embedded (PFPE tissues. In the current study, we focused on the analysis of phosphoproteins and the applicability of two-dimensional gel electrophoresis (2D-PAGE and enzyme-linked immunosorbent assay (ELISA to the analysis of a variety of malignant and non-malignant human tissues. Using western blot analysis, we found that phosphoproteins are quantitatively preserved in PFPE tissues, and signal intensities are comparable to that in paired, frozen tissues. Furthermore, proteins extracted from PFPE samples are suitable for 2D-PAGE and can be quantified by ELISA specific for denatured proteins. In summary, the PAXgene Tissue System reliably preserves phosphoproteins in human tissue samples, even after prolonged fixation or stabilization times, and is compatible with methods for protein analysis such as 2D-PAGE and ELISA. We conclude that the PAXgene Tissue System has the potential to serve as a versatile tissue fixative for modern pathology.

  9. Current Administrative court practice in the procedure of Public Procurement

    Directory of Open Access Journals (Sweden)

    Silvio Čović

    2017-01-01

    Full Text Available Under the current conditions of complex and difficult economic and social circumstances and given the comparative possibilities and economic effects, the system of public procurement which is firstly at a legal level regulated by the Public Procurement Act 8 (Zakon o javnoj nabavi of 2011 (further referred to as: PPA (ZN, is of particular importance for the entire legal, political and economic system of the Republic of Croatia. Public procurement in essence represents contracting the procurement of goods, works or services. The specifities of that system are comprised, above all, of regulation of entering contractual relations between the public and private sector. Therefore, this system in principle must be formal in order to protect equality of competitors in the public procurement procedure and also in the general interest. Appreciating the legal tradition and indigenous particularities, the author’s fundamental aims consisted of providing and analysing administrative court practice in the context of international legal acquis communautaire showing some legal regulation in practice of disputable aspects of the system of public procurement in Croatia and the doubts emerging from current administrative court practice.

  10. Artery Soft-Tissue Modelling for Stent Implant Training System

    Directory of Open Access Journals (Sweden)

    Giovanni Aloisio

    2004-08-01

    Full Text Available Virtual reality technology can be utilised to provide new systematic training methods for surgical procedures. Our aim is to build a simulator that allows medical students to practice the coronary stent implant procedure and avoids exposing patients to risks. The designed simulation system consists of a virtual environment and a haptic interface, in order to provide both the visualization of the coronary arteries and the tactile and force feedback generated during the interactions of the surgical instruments in the virtual environment. Since the arteries are soft tissues, their shape may change during an operation; for this reason physical modelling of the organs is necessary to render their behaviour under the influence of surgeon's instruments. The idea is to define a model that computes the displacement of the tissue versus time; from the displacement it is possible to calculate the response of the tissue to the surgical tool external stimuli. Information about tools displacements and tissue responses are also used to graphically model the artery wall and virtual surgical instrument deformations generated as a consequence of their coming into contact. In order to obtain a realistic simulation, the Finite Element Method has been used to model the soft tissues of the artery, using linear elasticity to reduce computational time and speed up interaction rates.

  11. E-invoicing in EU public procurement as a tool for cross border trade barriers elimination

    Directory of Open Access Journals (Sweden)

    Oleksandr TSARUK

    2015-12-01

    Full Text Available Public Procurement of goods and services always was one of the principal element of e-procurements because it effects economic growth, describes governments' public services and national competitiveness, level of human capital growth in a long run. Furthermore, researching EU policy on e-procurements demands to observe legislature essence and technological models of e-procurement solutions because none of which has not been developed as the universal one yet. Basic European agreements on public procurements and trade, combining with the currently used public procurement models, force to develop a commonly used framework for all EU countries. Monitoring of EU e-procurement system as model for implementation at Eastern partnerships countries was also suggested.

  12. Fy00 Treasure Valley ITS Deployment Project : advanced traffic management system (ATMS) software procurement and implementation process

    Science.gov (United States)

    2006-08-02

    In 2000, the Treasure Valley area of the State of Idaho received a federal earmark of $390,000 to develop an Advanced Transportation Management System (ATMS) for the Treasure Valley region of Idaho. The Ada County Highway District (ACHD), located in ...

  13. Interactivity of marketing and procurement

    Directory of Open Access Journals (Sweden)

    Lazarević Dragan

    2007-01-01

    Full Text Available General conclusions regarding the close links between marketing and procurement side of the marketing process would be expressed as follows: Interactive link between marketing and procurement is just proportionate to a level of company's market orientation. Establishment of an interactive link between marketing and procurement fields would reflect on pricing. Besides price competition, establishment of an integral approach through comprehensive understanding of market relations, will set up conditions for company to meet customers' needs in the most optimal way. Therefore the total result will be advanced and a company with this kind of orientation can become a market leader.

  14. 40 CFR 35.6565 - Procurement methods.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Procurement methods. 35.6565 Section 35... Actions Procurement Requirements Under A Cooperative Agreement § 35.6565 Procurement methods. The... purchase procedures are those relatively simple and informal procurement methods for securing services...

  15. Which role for public procurement in Italy. A premise

    OpenAIRE

    Traù Fabrizio

    2009-01-01

    This is a premise to a series of papers aimed at stressing the role that public procurement may play (and actually plays within specific industrial systems) as to the development and diffusion of innovative practices within manufacturing industry. The issue is addressed from the point of view of the guidelines for industrial policy recently set by National Authorities in the Italian experience. Among the papers a survey of the activity of the Italian Agency for public procurement (Consip) is ...

  16. Persepsi Pengguna Layanan Pengadaan Barang dan Jasa pada Pemerintah Kota Yogyakarta terhadap Implementasi Sistem E Procurement

    Directory of Open Access Journals (Sweden)

    Ita Akyuna Nightisabha

    2011-03-01

    Full Text Available This study aims to evaluate the implementation of electronic procurement of goods and services by the Government City of Yogyakarta, as an effort to create good governance especially in terms of procurement. This study compares the perceptions of user that consist of procurement committee and the providers of goods and services. Research location is in Layanan Pengadaan Secara Elektronik (LPSE of Government City of Yogyakarta as a system developer with the sample of the procurement committee and partner of goods and services that are spread in Yogyakarta and surrounding areas. This research uses t-test by using a reference measurement system on the success of end-user computing satisfaction developed by Torzadeh and Doll (1991. The results show a difference of perception between the committee and the procurement of goods and services providers to the implementation of e-proc system. There is difference in perception between users of e-procurement supplier of goods / services and the procurement committee. Implementation of e-procurement system is being run by the Government City of Yogyakarta is currently has not been relatively applied, because the technology gap that has led to the differences in perception between the committee and the procurement of goods and services providers.Keywords: good governance, e-procurement, perception

  17. Subordinate Mechanism of Legal Regulation of Relations in the Framework of the Contract Procurement System to Meet the Needs of the Public

    Directory of Open Access Journals (Sweden)

    Evgeny V. Solomonov

    2016-01-01

    Full Text Available The article discusses the theoretical issues of legal regulation mechanism features of separate stages of public procurement. Conclusions about the legal nature of the type of legal regulation, its relationship with the peculiarities of the legal facts and legal relations are given.

  18. System for tissue characterization using synchronous detection of diffuse reflectance

    International Nuclear Information System (INIS)

    Morales Lopez, Orestes M.; Stolik Isakina, Suren; La Rosa Vazquez, Jose Manuel de; Valor Reed, Alma

    2016-01-01

    The development of a system for the characterization of tissues optical properties in-vivo by synchronous detection of diffuse reflectance is presented. The system comprises an exploring probe with a linear spatial arrangement of optical fibers coupled to six lasers of 650 nm wavelength and a photodiode. The system also includes a preamplifier circuit for the photodiode, a driver for the amplitude modulation of the light signal of the lasers with optical power monitoring, a digital phase splitter for reference signal generation, an amplifying circuit with digitally switch able gain, a double phase demodulation circuit, an Arduino, and a control interface developed in LabVIEW. (Author)

  19. Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models...

  20. Procurement Policy for Armored Vehicles

    National Research Council Canada - National Science Library

    Jolliffe, Richard B; Burton, Bruce A; Carros, Deborah L; Schaefer, Beth K; Truong, Linh; Palmer, Kevin A; Chun, Judy M; Smith, Jessica M; Abraham, Amanda M; Peters, Anthony R

    2007-01-01

    Congresswoman Louise M. Slaughter requested that the Inspector General (IG), DoD review the DoD procurement history for body armor and armored vehicles and determine whether officials properly followed contracting policies...

  1. Monitoring and evaluation of green public procurement programs

    Energy Technology Data Exchange (ETDEWEB)

    Adell, Aure [Ecoinstitut, Barcelona (Spain); Schaefer, Bettina [Ecoinstitut, Barcelona (Spain); Ravi, Kavita [US Department of Energy, Washington, DC (United States); Corry, Jenny [Collaborative Labeling and Appliance Standards Program (United States)

    2013-10-15

    Effective procurement policies can help governments save considerable amounts of money while also reducing energy consumption. Additionally, private sector companies which purchase large numbers of energy-consuming devices can benefit from procurement policies that minimize life-cycle energy costs. Both public and private procurement programs offer opportunities to generate market-transforming demand for energy efficient appliances and lighting fixtures. In recent years, several governments have implemented policies to procure energy efficient products and services. When deploying these policies, efforts have focused on developing resources for implementation (guidelines, energy efficiency specifications for tenders, life cycle costing tools, training, etc.) rather than defining monitoring systems to track progress against the set objectives. Implementation resources are necessary to make effective policies; however, developing Monitoring and Evaluation (M and E) mechanisms are critical to ensure that the policies are effective. The purpose of this article is to provide policy makers and procurement officials with a preliminary map of existing approaches and key components to monitor Energy Efficient Procurement (EEP) programs in order to contribute to the improvement of their own systems. Case studies are used throughout the paper to illustrate promising approaches to improve the M and E of EEP programs, from the definition of the system or data collection to complementary instruments to improve both the monitoring response and program results.

  2. Nuclear power equipment procurement management under EPC mode

    International Nuclear Information System (INIS)

    Shuai Yuezhi

    2014-01-01

    Nuclear power equipment procurement is one of the major constraints and management difficulties in the process of domestic nuclear power project construction for a long time. The construction of Hainan Changjiang Project can not meet the milestones due to the major equipment supply delay. Through the introduction to the organization and features of Changjiang project equipment procurement under EPC mode, and the main problems in the procurement process and its reason analysis, the purpose of this paper is to put forward ideas and suggestions of these items, i.e. selection of equipment suppliers, equipment localization, mass material design and procurement, complete system equipment supply, spare parts delivery and storage, owner process management, providing reference for follow-up projects. (author)

  3. Systemic connective tissue features in women with fibromuscular dysplasia.

    Science.gov (United States)

    O'Connor, Sarah; Kim, Esther Sh; Brinza, Ellen; Moran, Rocio; Fendrikova-Mahlay, Natalia; Wolski, Kathy; Gornik, Heather L

    2015-10-01

    Fibromuscular dysplasia (FMD) is a non-atherosclerotic disease associated with hypertension, headache, dissection, stroke, and aneurysm. The etiology is unknown but hypothesized to involve genetic and environmental components. Previous studies suggest a possible overlap of FMD with other connective tissue diseases that present with dissections and aneurysms. The aim of this study was to investigate the prevalence of connective tissue physical features in FMD. A total of 142 FMD patients were consecutively enrolled at a single referral center (97.9% female, 92.1% of whom had multifocal FMD). Data are reported for 139 female patients. Moderately severe myopia (29.1%), high palate (33.1%), dental crowding (29.7%), and early-onset arthritis (15.6%) were prevalent features. Classic connective features such as hypertelorism, cleft palate, and hypermobility were uncommon. The frequency of systemic connective tissue features was compared between FMD patients with a high vascular risk profile (having had ⩾1 dissection and/or ⩾2 aneurysms) and those with a standard vascular risk profile. A history of spontaneous pneumothorax (5.9% high risk vs 0% standard risk) and atrophic scarring (17.6% high risk vs 6.8% standard risk) were significantly more prevalent in the high risk group, pconnective tissue features such as high palate and pneumothorax were more prominent among FMD patients with a high vascular risk profile. © The Author(s) 2015.

  4. Procurement engineering - the productivity factor

    Energy Technology Data Exchange (ETDEWEB)

    Bargerstock, S.B. (TENERA, L.P., Chattanooga, TN (United States))

    1993-01-01

    The industry is several years on the road to implementation of the Nuclear Management and Resources Council (NUMARC) initiatives on commercial-grade item dedication and procurement. Utilities have taken several approaches to involve engineering in the procurement process. A common result for the approaches is the additional operations and maintenance (O M) cost imposed by the added resource requirements. Procurement engineering productivity is a key element in controlling this business area. Experience shows that 400 to 500% improvements in productivity are possible with a 2-yr period. Improving the productivity of the procurement engineering function is important in today's competitive utility environment. Procurement engineering typically involves four distinct technical evaluation responsibilities along with several administrative areas. Technical evaluations include the functionally based safety classification of replacement components and parts (lacking a master parts list), the determination of dedication requirements for safety-related commercial-grade items, the preparation of a procurement specification to maintain the licensed design bases, and the equivalency evaluation of alternate items not requiring the design-change process. Administrative duties include obtaining technical review of vendor-supplied documentation, identifying obsolete parts and components, resolving material nonconformances, initiating the design-change process for replacement items (as needed), and providing technical support to O M. Although most utilities may not perform or require all the noted activities, a large percentage will apply to each utility station.

  5. Procurement engineering - the productivity factor

    International Nuclear Information System (INIS)

    Bargerstock, S.B.

    1993-01-01

    The industry is several years on the road to implementation of the Nuclear Management and Resources Council (NUMARC) initiatives on commercial-grade item dedication and procurement. Utilities have taken several approaches to involve engineering in the procurement process. A common result for the approaches is the additional operations and maintenance (O ampersand M) cost imposed by the added resource requirements. Procurement engineering productivity is a key element in controlling this business area. Experience shows that 400 to 500% improvements in productivity are possible with a 2-yr period. Improving the productivity of the procurement engineering function is important in today's competitive utility environment. Procurement engineering typically involves four distinct technical evaluation responsibilities along with several administrative areas. Technical evaluations include the functionally based safety classification of replacement components and parts (lacking a master parts list), the determination of dedication requirements for safety-related commercial-grade items, the preparation of a procurement specification to maintain the licensed design bases, and the equivalency evaluation of alternate items not requiring the design-change process. Administrative duties include obtaining technical review of vendor-supplied documentation, identifying obsolete parts and components, resolving material nonconformances, initiating the design-change process for replacement items (as needed), and providing technical support to O ampersand M. Although most utilities may not perform or require all the noted activities, a large percentage will apply to each utility station

  6. Sustainable Procurement in Practice: Explaining the Degree of Sustainable Procurement from an Organisational Perspective

    NARCIS (Netherlands)

    J. Grandia (Jolien); S.M. Groeneveld (Sandra); B.S. Kuipers (Ben); A.J. Steijn (Bram)

    2013-01-01

    textabstractSustainable procurement is often used to reduce negative environmental impacts related to production and consumption. Several studies in the sustainable procurement literature have identified potential drivers of and barriers to sustainable procurement, which are often organisational in

  7. Cyclic AMP system in muscle tissue during prolonged hypokinesia

    Science.gov (United States)

    Antipenko, Y. A.; Bubeyev, Y. A.; Korovkin, B. F.; Mikhaleva, N. P.

    1980-01-01

    Components of the cyclic Adenosine-cyclic-35-monophosphate (AMP) system in the muscle tissue of white rats were studied during 70-75 days of hypokinesia, created by placing the animals in small booths which restricted their movements, and during the readaptation period. In the initial period, cyclic AMP levels and the activities of phosphodiesterase and adenylate cyclase in muscle tissue were increased. The values for these indices were roughly equal for controls and experimental animals during the adaptation period, but on the 70th day of the experiment cAMP levels dropped, phosphodiesterase activity increased, and the stimulative effect of epinephrine on the activity of adenylate cyclase decreased. The indices under study normalized during the readaptation period.

  8. Procurement in the Nuclear Industry, Quality, Safety and Decision Making

    International Nuclear Information System (INIS)

    Jakobsson, Marianne; Svenson, Ola; Salo, Ilkka

    2010-03-01

    are formed. This means that external personal sometimes has to be engaged in such a team and therefore the emphasis on safety has to be communicated effectively to those joining the team from outside the plant. From a competition point of view, the number of potential suppliers is often too small. There is a feedback system of experience from previous contracts, but this information is of little use since it is not documented so that it is possible to conduct a quick and efficient information search, which would be a weakness when safety and quality information is needed quickly in a procurement process

  9. PROCUREMENT INSOURCING VS. PROCUREMENT OUTSOURCING: EVIDENCE FROM SERBIA

    Directory of Open Access Journals (Sweden)

    Slobodan Acimovic

    2016-11-01

    Full Text Available One of the most important strategic decisions of a company is to choose whether to insource or outsource a particular group of activities or a business function. The trend of outsourcing those activities which do not form a part of the company core competences is becoming more and more present in business practice. The aim of the analysis within this paper is to review the mentioned trend from the position of organizing the company procurement activities. The analysis shows that there is no unique trend concerning outsourcing all logistics activities, which do not form a part of the company core competences. Unlike the majority of other logistics activities, which as non-basic, tend to be outsourced, procurement dominantly stays insourced. Finally, based on the empirical evidence obtained from a survey carried out among 52 companies in Serbia, it is concluded that even if procurement is outsourced, this trend is more present among service than production companies.

  10. Financial aspects of organ procurement from deceased donors in the USA-Relevance to xenotransplantation.

    Science.gov (United States)

    Saari, Ryan J; Cooper, David K C

    2017-07-01

    When clinical xenotransplantation is introduced, the costs associated with acquisition of a genetically engineered pig organ are as yet unknown. How will these costs compare with those currently associated with the acquisition of deceased human organs? An understanding of the financial aspects of deceased organ and tissue procurement in the USA is therefore worthwhile. We have therefore attempted to review certain economic aspects of non-profit and for-profit organizations that provide cadaveric organs and/or tissues for purposes of transplantation into patients with end-stage organ failure, cellular deficiencies, or in need of reconstructive procedures. We briefly consider the laws, organizations, and business practices that govern the acquisition, processing, and/or distribution of cadaveric organs and tissues, and the economic implications of industry practices. In particular, we explore and highlight what we perceive as a lack of transparency and oversight with regard to financial practices, and we question whether donor families would be entirely happy with the business environment that has developed from their altruistic donations. Until xenotransplantation becomes established clinically, which will negate the need for any system of organ procurement and allocation, we suggest that those involved in organ and cell transplantation, as well as those who participate in reconstructive surgery, should take responsibility to ensure that the financial practices associated with procurement are transparent, and overseen/regulated by a responsible authority. We suggest the major transplant societies should take a lead in this respect. The ability to acquire a genetically engineered pig organ whenever required through a simple commercial transaction (as in the acquisition of a life-saving drug) will be greatly to the patient's benefit. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. 49 CFR 661.11 - Rolling stock procurements.

    Science.gov (United States)

    2010-10-01

    ...) Primary AC transformer rectifiers (3) DC switch gear (4) Traction power console and CRT display system at... engine, transmission, axles, including the cooling and braking systems; the installation and... system is being procured as the end product by the grantee, the installation of the system qualifies as...

  12. Tissue hypoxygenation activates the adrenomedullin system in vivo

    DEFF Research Database (Denmark)

    Hofbauer, K H; Jensen, B L; Kurtz, A

    2000-01-01

    Our study aimed to investigate the influence of tissue hypo-oxygenation on the adrenomedullin (ADM) system in vivo. For this purpose, male Sprague-Dawley rats were exposed to normobaric hypoxia (8% oxygen) or to functional anemia [0.1% carbon monoxide (CO)] or to cobalt chloride (60 mg/kg) for 6 h......-fold in all organs examined. Similarly, ADM-R mRNA abundance increased during hypoxia and CO inhalation in all organs examined with exception of the liver. The effects of hypoxia and of CO inhalation on ADM and ADM-R mRNAs were mimicked by injection of cobaltous chloride. Hypoxia also significantly...

  13. THE BARRIERS OF IMPLEMENTING E-PROCUREMENT

    Directory of Open Access Journals (Sweden)

    Corina Pop Sitar

    2011-01-01

    Full Text Available The concept of e-procurement has many different meanings ranging from shopping on theinternet (through reverse auction to collaborative initiatives taking place in virtualmeetings. There are many forms of e-procurement that can be found in the literature. In thispaper we define the most important forms of e-procurement. Next, we present the mainbarriers of implementing an e-procurement found in the literature. Furthermore, we presenta matrix with the main barriers of e-procurement classified in four main categories. Finally,we elaborated for managers some guidelines in order to overcome the barriers ofimplementing e-procurement.

  14. The Determinants of the Compliance to Public Procurement Policy Requirements among Public Enterprises in Zimbabwe

    OpenAIRE

    Maxwell Sandada; Portia Kambarami

    2016-01-01

    Many public entities in Zimbabwe are operating in a very volatile environment characterised by public procurement systems open to abuse. Zimbabwe is one of the first countries in Africa to have a Procurement Act however non-compliance issues are still a challenge. Public procurement scandals have been a hot topic with the media and also with the Report of the Auditor General for the financial year ended December 31, 2014 having picked on a lot of issues relating to non-complian...

  15. Topical legal aspects of corruption counteraction in public procurement

    Directory of Open Access Journals (Sweden)

    Aleksandr Igorevich Zemlin

    2015-03-01

    Full Text Available Objective to analyze the current developments in the Russian legislation on corruption counteraction and the legislation on public procurement system on this basis to study legal conflicts and gaps and to develop proposals under the provisions of the National AntiCorruption Plan for 2014ndash2015. Methods historical formallegal logical and systemicfunctional structural and contextual approach to the study of law and theoretical propositions concerning the definition nature and characteristics of legal relations arising in the process of and relating to the corruption counteraction in the public procurement system. Results аn aggregate of theoretical conclusions and proposals aimed at perfection of anticorruption legislation and legislation on the contractual public procurement system is presented. Scientific novelty the results of the author39s interpretation of changes in the Russian anticorruption legislation and legislation on the contractual public procurement system existing legal conflicts and gaps. Practical significance developing proposals for improving the standards of anticorruption legislation and legislation on public procurement system under the provisions of the National AntiCorruption Plan for 2014ndash2015. nbsp

  16. PVUSA procurement, acceptance, and rating practices for photovoltaic power plants

    Energy Technology Data Exchange (ETDEWEB)

    Dows, R.N.; Gough, E.J.

    1995-09-01

    This report is one in a series of PVUSA reports on PVUSA experiences and lessons learned at the demonstration sites in Davis and Kerman, California, and from participating utility host sites. During the course of approximately 7 years (1988--1994), 10 PV systems have been installed ranging from 20 kW to 500 kW. Six 20-kW emerging module technology arrays, five on universal project-provided structures and one turnkey concentrator, and four turnkey utility-scale systems (200 to 500 kW) were installed. PVUSA took a very proactive approach in the procurement of these systems. In the absence of established procurement documents, the project team developed a comprehensive set of technical and commercial documents. These have been updated with each successive procurement. Working closely with vendors after the award in a two-way exchange provided designs better suited for utility applications. This report discusses the PVUSA procurement process through testing and acceptance, and rating of PV turnkey systems. Special emphasis is placed on the acceptance testing and rating methodology which completes the procurement process by verifying that PV systems meet contract requirements. Lessons learned and recommendations are provided based on PVUSA experience.

  17. Rethinking health sector procurement as developmental linkages in East Africa.

    Science.gov (United States)

    Mackintosh, Maureen; Tibandebage, Paula; Karimi Njeru, Mercy; Kariuki Kungu, Joan; Israel, Caroline; Mujinja, Phares G M

    2018-03-01

    Health care forms a large economic sector in all countries, and procurement of medicines and other essential commodities necessarily creates economic linkages between a country's health sector and local and international industrial development. These procurement processes may be positive or negative in their effects on populations' access to appropriate treatment and on local industrial development, yet procurement in low and middle income countries (LMICs) remains under-studied: generally analysed, when addressed at all, as a public sector technical and organisational challenge rather than a social and economic element of health system governance shaping its links to the wider economy. This article uses fieldwork in Tanzania and Kenya in 2012-15 to analyse procurement of essential medicines and supplies as a governance process for the health system and its industrial links, drawing on aspects of global value chain theory. We describe procurement work processes as experienced by front line staff in public, faith-based and private sectors, linking these experiences to wholesale funding sources and purchasing practices, and examining their implications for medicines access and for local industrial development within these East African countries. We show that in a context of poor access to reliable medicines, extensive reliance on private medicines purchase, and increasing globalisation of procurement systems, domestic linkages between health and industrial sectors have been weakened, especially in Tanzania. We argue in consequence for a more developmental perspective on health sector procurement design, including closer policy attention to strengthening vertical and horizontal relational working within local health-industry value chains, in the interests of both wider access to treatment and improved industrial development in Africa. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. URGENSI STUDI TENTANG PROCUREMENT CONTRACT

    Directory of Open Access Journals (Sweden)

    Yohanes Sogar Simamora

    2006-01-01

    Full Text Available Contractualization is kind of goverment activity in acquiring goods, services and infrastructure as well. Procurement contract has several important function especially in enhancing economic development in a state. In Indonesia, this kind of contract also has function in empowering micro economic scale. Since the aim of procurement study is to provide equal protection between public fund interest in one hand and privat sector in the other hand, general principle of contract law must be taken into consideration together with transparency as the most important principle in government contract.

  19. Malawi : Country Procurement Assessment Report, Volume 1. Main Findings and Recommendations

    OpenAIRE

    World Bank

    2004-01-01

    The Malawi Country Procurement Assessment Report is a joint undertaking between the Malawi Government and the World Bank to analyze the country procurement system and recommend appropriate actions to improve the efficiency, economy and transparency of the system. This report is divided into (a) an Executive Summary, (b) Main Report on Findings and Recommendations, and (c) Annexes. Since th...

  20. Systemic Aspects of Soft Tissue Rheumatic Disorders (STRDs)

    International Nuclear Information System (INIS)

    Owlia, M. B.; Mehrpoor, G.

    2014-01-01

    Objective: To determine the markers of systemic inflammation in soft tissue rheumatic disorders (STRDs). Study Design: Case series. Place and Duration of Study: Rheumatology Clinic, Yazd, Iran, from November 2010 to December 2011. Methodology: Patients aged 20 years or above with known diagnosis of STRD according to clinical criteria and/ or paraclinical investigations for at least 3 weeks duration were longitudinally followed. Patients with diagnosis of rheumatoid arthritis, hypothyroidism, or any other known systemic conditions (other than diabetes mellitus) were excluded. After careful and detailed history taking, laboratory tests indicating systemic inflammation including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and routine screening rheumatologic tests were assessed. Results: Of the 90 patients, 75% were female and 25% were male and 28 (31.1%) of patients had diabetes mellitus. Fifty six (62%) and 49 (54%) of all studies cases had some degrees of morning stiffness and remarkable fatigue respectively. Twenty two (24%) had elevated CRP and 5 (5.5%) had abnormal ESR. Rheumatoid factor (RF) and anti-CCP was positive in 5 (5.5%) and 12 (13.3%) of patients accordingly. Three (3.3%) patients suffered from anemia of chronic disease. Mean ESR was 48 A +- 7.34 (hl) and mean CRP was 10.06 A +- 1.96 mg/dl. Mean RF was 10.8 A +- 1.64 U/ml and mean anti- CCP was 18.5 A +- 2.71 U/ml. Mean hemoglobin was between 10.4 A +- 1.01 g/dl. Conclusion: Features of subtle systemic inflammation are positive in some cases of soft tissue rheumatism. (author)

  1. The necessity of strengthening the cooperation between tissue banks and organ transplant organizations at national, regional, and international levels.

    Science.gov (United States)

    Morales Pedraza, Jorge

    2013-12-01

    The donation of tissues and organs increases significantly when tissue banks and organ transplant organizations work together in the procurement of organs and tissues at donor sources (hospitals, coroners system, organ procurement agencies, and funeral homes, among others). To achieve this important goal, national competent health authorities should considered the establishment of a mechanism that promote the widest possible cooperation between tissue banks and organ transplant organizations with hospitals, research medical institutions, universities, and other medical institutions and facilities. One of the issues that can facilitate this cooperation is the establishment of a coding and traceability system that could identify all tissues and organs used in transplant activities carried out in any country. The promotion of national, regional, and international cooperation between tissue banks and organ transplant organizations would enable the sharing of relevant information that could be important for medical practice and scientific studies carried out by many countries, particularly for those countries with a weak health care system.

  2. Public Procurement of Innovation in Sweden

    DEFF Research Database (Denmark)

    Rolfstam, Max; Ågren, Robert

    2014-01-01

    Sweden is often thought of as a country with a strong tradition for using public procurement as a means to stimulate innovation. Early on, Sweden recognized and developed procedures for using public procurement as a technologydevelopment tool. After a period where emphasis was put on this aspect ...... government authorities to engage in public procurement for innovation, and by issuing guidance on the topic.......Sweden is often thought of as a country with a strong tradition for using public procurement as a means to stimulate innovation. Early on, Sweden recognized and developed procedures for using public procurement as a technologydevelopment tool. After a period where emphasis was put on this aspect...... of public procurement Sweden dropped many policy initiatives within this field. This was in part due to neo-liberal movements during the 1980s which in interaction with a distributed institutional setup led to the removal of incentives for a procuring authority to engage in public procurement of innovation...

  3. Technical Parts For Application E-Procurement in the Republic of Kosovo

    Directory of Open Access Journals (Sweden)

    Besnik HAJDARI

    2018-04-01

    Full Text Available Electronic procurement in the Republic of Kosovo has begun in 2012, had it not been for the accomplishment goals and development and implementation of electronic procurement in the Republic of Kosovo fully realized. e-Procurement is not only the publication of procurement results, but is a reflection of a defined legal process on procurement. The Internet are presented records of all claims, also via the Internet can be sent to all offers. Research: Through management system throughout the procurement process electronically will enable the preservation of technical and financial evaluation of bids. Thus, the presentation of this process in a transparent manner increases the reliability and efficiency. Method: Also through the management system of this process, according to the rights defined by law, each party can see the appeal process and remotely via the Internet. Implementation of e-procurement will enable the removal of barriers that were presented earlier, increasing the confidence of all parties involved. Access will be granted to all interested parties by allowing the approaches to the law, while in the case of restrictions should use electronic identification (e-ID. Result: The categorization of approaches will be for each separately, including contracting authority, contractors, bidders, complainers, the proxies of budgetary units, auditors and other categories defined under applicable laws. Security of information in e-procurement will be the maximum. As with any other service access to e-procurement will be provided through the state portal.

  4. public procurement, governance and economic growth

    African Journals Online (AJOL)

    GRACE

    Development (OECD) sees public procurement ―as a strategic policy lever to advance ... financial markets and provision of advisory services to businesses and government. ... Procurement established by the Section 3 of the Act. The BPP is the ... present annual reports to the Minister on the public procurement processes;.

  5. 78 FR 37525 - Procurement List; Deletions

    Science.gov (United States)

    2013-06-21

    .... Contracting Activity: Dept of the Air Force, FA7014 AFDW A7KI, Andrews AFB, MD. Service Type/Location: Laundry... Procurement List. SUMMARY: This action deletes products and services from the Procurement List that were... products and services listed below are no longer suitable for procurement by the Federal Government under...

  6. 22 CFR 226.46 - Procurement records.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procurement records. 226.46 Section 226.46 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.46 Procurement records...

  7. 10 CFR 436.43 - Procurement planning.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Procurement planning. 436.43 Section 436.43 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Agency Procurement of Energy Efficient Products § 436.43 Procurement planning. (a) Agencies should consider the...

  8. 10 CFR 21.31 - Procurement documents.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procurement documents. 21.31 Section 21.31 Energy NUCLEAR REGULATORY COMMISSION REPORTING OF DEFECTS AND NONCOMPLIANCE Procurement Documents § 21.31 Procurement documents. Each individual, corporation, partnership, dedicating entity, or other entity subject to the...

  9. 7 CFR 225.17 - Procurement standards.

    Science.gov (United States)

    2010-01-01

    ...) Procurements by public sponsors comply with applicable State or local laws and the standards set forth in 7 CFR part 3016; and (2) Procurements by private nonprofit sponsors comply with standards set forth in 7 CFR... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement standards. 225.17 Section 225.17...

  10. 10 CFR 603.1300 - Procurement contract.

    Science.gov (United States)

    2010-01-01

    ... Used in this Part § 603.1300 Procurement contract. A Federal Government procurement contract. It is a... 10 Energy 4 2010-01-01 2010-01-01 false Procurement contract. 603.1300 Section 603.1300 Energy... Government and a State, a local government, or other non-government entity when the principal purpose of the...

  11. 32 CFR 37.1330 - Procurement contract.

    Science.gov (United States)

    2010-07-01

    ... REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1330 Procurement contract. A Federal Government procurement contract. It is a legal instrument which, consistent with 31 U.S... 32 National Defense 1 2010-07-01 2010-07-01 false Procurement contract. 37.1330 Section 37.1330...

  12. Tanzania : Country Procurement Assessment Report, Executive Summary

    OpenAIRE

    World Bank

    2004-01-01

    This Country Procurement Assessment Report (CPAR)intends to determine the compatibility of national procurement law, and practices, with the principles of economy, and with international procurement practices. This CPAR, the second of its kind in Tanzania, looks at the legislative framework, the performance of regulatory functions, the enforcement regime, and the capacity of public sector ...

  13. 76 FR 43988 - Procurement List; Additions

    Science.gov (United States)

    2011-07-22

    ... this work, based on applicable experience. Finally, the purpose of the JWOD Act and the responsibility... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Additions... Procurement List. SUMMARY: This action adds products and services to the Procurement List that will be...

  14. 7 CFR 1780.72 - Procurement methods.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Procurement methods. 1780.72 Section 1780.72..., Constructing and Inspections § 1780.72 Procurement methods. Procurement shall be made by one of the following methods: Small purchase procedures; competitive sealed bids (formal advertising); competitive negotiation...

  15. 76 FR 26279 - Procurement List; Proposed Additions

    Science.gov (United States)

    2011-05-06

    ...-service area; clean and sanitize food service equipment, utensil cleaning, and dishwashing; clean pots... additions to the Procurement List. SUMMARY: The Committee is proposing to add services to the Procurement... in this notice will be required to procure the services listed below from nonprofit agencies...

  16. Competitive Procurement and Asset Specificity

    NARCIS (Netherlands)

    Sorana, V.

    2003-01-01

    This paper studies the effects of asset specificity on the performance of procurement auctions with subcontracting and asset sales.The analysis highlights the role of several asset features like transfer costs, type of alternative uses and maintenance requirements.It is argued that, if bargaining

  17. Organ procurement: let's presume consent

    OpenAIRE

    Moustarah, F

    1998-01-01

    IN WINNING FIRST PRIZE in the Logie Medical Ethics Essay Contest in 1997, Dr. Fady Moustarah made a strong and compelling argument in favour of presumed consent in the procurement of donor organs. He stressed that a major education campaign will be needed when such a policy is adopted lest some people begin to regard physicians as "organ vultures."

  18. Donation FAQs (Bone and Tissue Allografts)

    Science.gov (United States)

    ... Biologics is affiliated with organ, eye and tissue procurement agencies throughout the U.S. They typically ... Visit DonateLife.net and learn how your gift of tissue can give bring new life to ...

  19. United Kingdom: Procurement Related Nuclear Experience (Operating Experience)

    International Nuclear Information System (INIS)

    2016-01-01

    Procurement of nuclear facilities in the United Kingdom is subject to nuclear site licence conditions issued by the Government through the Office for Nuclear Regulation (ONR). Each nuclear facility in the United Kingdom must have a nuclear site licence and must comply with the 36 general conditions that are set out in the Licence Condition Handbook (October 2014). In addition, the ONR has published a technical assessment guide for the procurement of nuclear safety related items or services; a guide on intelligent customers and a guide on records management also apply to the procurement phase, and ONR interventions look across all three of these documents. Procurement governance arrangements need to be developed (including a policy, manual, procedures and template documents) and approved within the utility company. The ONR monitors the arrangements via interventions and deems the arrangements to be ‘adequate’. Some procurement contracts become lifetime records for nuclear safety related systems and need to be retained while the plant is in place. A formal record retention schedule needs to be created and managed by the procurement organization. The utility company may elect to set hold points during the various procurement stages and, importantly, obtain approval for the contract and its content from all technical stakeholders (with particular emphasis on the engineering, project management and design authority quality functions before contract award). For contracts with high nuclear safety significance, the ONR may enforce additional hold points before and/or after contract award. There is a general requirement that the utility puts in place adequate arrangements to ensure that suitably qualified and experienced personnel are employed to implement adequate management arrangements and to act as an intelligent customer. This includes being able to demonstrate that any contractor or supplier is suitable, capable and experienced, and has the necessary processes and

  20. Strategic contracting practices to improve procurement of health commodities.

    Science.gov (United States)

    Arney, Leslie; Yadav, Prashant; Miller, Roger; Wilkerson, Taylor

    2014-08-01

    Public-sector entities responsible for procurement of essential medicines and health commodities in developing countries often lack the technical capacity to efficiently ensure supply security. Under strict public scrutiny and pressures to be transparent, many agencies continue to use archaic procurement methods and to depend on inflexible forecasts and cumbersome tendering processes. On the basis of semi-structured literature reviews and interviews, we identified framework agreements as a strategic procurement practice used by the U.S. federal government that may also be suitable for global health supply chains. Framework agreements are long-term contracts that provide the terms and conditions under which smaller repeat purchasing orders may be issued for a defined period of time. Such agreements are common in U.S. and United Nations procurement systems and in other developed countries and multilateral organizations. In contrast, framework agreements appear to be seldom used in procurement of health commodities in countries of sub-Saharan Africa. The current practice of floating tenders multiple times a year contributes to long lead times and stock-outs, and it hampers the manufacturer's or supplier's ability to plan and respond to the government's needs. To date, government's use of strategic contracting practices in public procurement of health commodities has not received much attention in most developing countries. It may present an opportunity for substantial improvements in procurement efficiency and commodity availability. Enabling legislation and strengthened technical capacity to develop and manage long-term contracts could facilitate the use of framework contracts in sub-Saharan Africa, with improved supply security and cost savings likely to result.

  1. Human rights violations in organ procurement practice in China.

    Science.gov (United States)

    Paul, Norbert W; Caplan, Arthur; Shapiro, Michael E; Els, Charl; Allison, Kirk C; Li, Huige

    2017-02-08

    Over 90% of the organs transplanted in China before 2010 were procured from prisoners. Although Chinese officials announced in December 2014 that the country would completely cease using organs harvested from prisoners, no regulatory adjustments or changes in China's organ donation laws followed. As a result, the use of prisoner organs remains legal in China if consent is obtained. We have collected and analysed available evidence on human rights violations in the organ procurement practice in China. We demonstrate that the practice not only violates international ethics standards, it is also associated with a large scale neglect of fundamental human rights. This includes organ procurement without consent from prisoners or their families as well as procurement of organs from incompletely executed, still-living prisoners. The human rights critique of these practices will also address the specific situatedness of prisoners, often conditioned and traumatized by a cascade of human rights abuses in judicial structures. To end the unethical practice and the abuse associated with it, we suggest to inextricably bind the use of human organs procured in the Chinese transplant system to enacting Chinese legislation prohibiting the use of organs from executed prisoners and making explicit rules for law enforcement. Other than that, the international community must cease to abet the continuation of the present system by demanding an authoritative ban on the use of organs from executed Chinese prisoners.

  2. The viability of the competitive procurement of black start: Lessons from the RTOs

    Energy Technology Data Exchange (ETDEWEB)

    Isemonger, Alan G.

    2007-10-15

    The procurement of black start services is a vital component of system restoration in all markets, not only deregulated ones. ERCOT and other jurisdictions have working methods of competitive procurement that allow an explicit market mechanism to make the cost tradeoffs, while taking account of the network topology. (author)

  3. The Mice Drawer System Tissue Sharing Program (MDS-TSP)

    Science.gov (United States)

    Biticchi, Roberta; Cancedda, Ranieri; Cilli, Michele; Cotronei, Vittorio; Costa, Delfina; Liu, Yi; Piccardi, Federica; Pignataro, Salvatore; Ruggiu, Alessandra; Tasso, Roberta; Tavella, Sara

    Several organs and apparatus are affected by weightless conditions and in particular by the weightless experienced during space flights. Therefore space missions are good opportunities to investigate in a whole organism the controlling cellular and molecular mechanisms. For this type of studies mice represent an excellent animal model for several reasons: reduced body size, relatively short time needed to reach adulthood, availability of strains with different genetic background and of different transgenic lines, etc. In line with the International Space Station (ISS) development, the Italian Space Agency (ASI) contracted Thales Alenia Space Italia, the largest Italian aerospace industry, to design and build a spaceflight payload for rodent research on ISS, the Mouse Drawer System (MDS -see abstract P. Cipparelli et al.). This payload meets NIH guideline for several physical parameters to maintain 6 animals in good health conditions in a space environment. Given the interest of our laboratory in the microgravity induced skeleton alterations, we focused our attention on transgenic mice over-expressing pleiotrophin (PTN) under the control of the human bone specific osteocalcin promoter. This protein is a heparin-binding cytokine with different functions. PTN is expressed by the cells in an early differentiation stage and is upregulated in tissue injury and wound repair. PTN is specifically involved in bone formation, neurite outgrowth and angiogenesis. As PTN-transgenic mice show an increased bone mass and mineralization, we decided to use this mouse model in the flight experiment and to study its potential role in counteracting bone loss in microgravity. Not all mouse strains are equally suitable for flight. After preliminary tests in the MDS breadboard at our animal facility on the behavior of different mouse strains, PTN-transgenic mice originally obtained in the BDF strain were backcrossed in the C57Bl/J10 strain before being used in this study. In order to

  4. Good Governance in Public Procurement: A South African Case Study

    Directory of Open Access Journals (Sweden)

    R Roos

    2008-08-01

    Full Text Available In this article good governance in public procurement, with particular reference to accountability is discussed. The principle of providing adequate remedies in public procurement is put under the spotlight. This is done with reference to the decision in Steenkamp NO v Provincial Tender Board, Eastern Cape. In this case the Constitutional Court had to consider whether an initially successful tenderer could lodge a delictual claim for damages to compensate for expenses incurred after conclusion of a contract, which was subsequently rendered void on an application for review of the tender award. The applicable principles of good governance and the applicable provisions of the UNCITRAL Model Law on Public Procurement and the WTO plurilateral Government Procurement Agreement are analysed. This is done to enable an evaluation of the decision by the Constitutional Court in the above case. It is concluded that the South African public procurement system does in this instance comply with the basic principles of good governance with regard to accountability.

  5. Analysis of Market Concentration in Selected Sectors of Public Procurement

    Directory of Open Access Journals (Sweden)

    Petr Svoboda

    2016-01-01

    Full Text Available The goal of this article is the analysis of influence of market concentration in selected areas of public procurement on chosen parameters of public procurement in years 2007 and 2011. Five concentration ratios and five parameters of contracts are calculated for each of five chosen areas of public tenders in 2007 and 2011. After this task, the correlation analysis between concentration ratios and parameters of contracts is done for finding out mutual relation between these two variables. Correlation analysis is then compared with four created hypotheses about the relationship between market concentration and parameters of public procurement The results of the analysis are surprising, because in most cases, the stated hypotheses were rejected, meaning that the correlations between the parameters of public procurement and market concentration were different than this study predicted based on economic theory. The possible reasons for this result, discussed in the article, are corruption and also poor quality of data from Information system of public procurement administered by the Ministry for Regional Development of Czech Republic.

  6. Methylcellulose Based Thermally Reversible Hydrogel System for Tissue Engineering Applications

    Directory of Open Access Journals (Sweden)

    Ram V. Devireddy

    2013-06-01

    Full Text Available The thermoresponsive behavior of a Methylcellulose (MC polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effects of polymer concentration, molecular weight and dissolved salts on the gelation of three commercially available MCs using differential scanning calorimeter and rheology. For investigation of the hydrogel stability and fluid uptake capacity, swelling and degradation experiments were performed with the hydrogel system exposed to cell culture solutions at incubation temperature for several days. From these experiments, the optimal composition of MC-water-salt that was able to produce stable hydrogels at or above 32 °C, was found to be 12% to 16% of MC (Mol. wt. of 15,000 in water with 0.5× PBS (~150mOsm. This stable hydrogel system was then evaluated for a week for its efficacy to support the adhesion and growth of specific cells in culture; in our case the stromal/stem cells derived from human adipose tissue derived stem cells (ASCs. The results indicated that the addition (evenly spread of ~200 µL of 2 mg/mL bovine collagen type -I (pH adjusted to 7.5 over the MC hydrogel surface at 37 °C is required to improve the ASC adhesion and proliferation. Upon confluence, a continuous monolayer ASC sheet was formed on the surface of the hydrogel system and an intact cell sheet with preserved cell–cell and cell–extracellular matrix was spontaneously and gradually detached when the grown cell sheet was removed from the incubator and exposed to room temperature (~30 °C within minutes.

  7. Methylcellulose based thermally reversible hydrogel system for tissue engineering applications.

    Science.gov (United States)

    Thirumala, Sreedhar; Gimble, Jeffrey M; Devireddy, Ram V

    2013-06-25

    The thermoresponsive behavior of a Methylcellulose (MC) polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effects of polymer concentration, molecular weight and dissolved salts on the gelation of three commercially available MCs using differential scanning calorimeter and rheology. For investigation of the hydrogel stability and fluid uptake capacity, swelling and degradation experiments were performed with the hydrogel system exposed to cell culture solutions at incubation temperature for several days. From these experiments, the optimal composition of MC-water-salt that was able to produce stable hydrogels at or above 32 °C, was found to be 12% to 16% of MC (Mol. wt. of 15,000) in water with 0.5× PBS (~150mOsm). This stable hydrogel system was then evaluated for a week for its efficacy to support the adhesion and growth of specific cells in culture; in our case the stromal/stem cells derived from human adipose tissue derived stem cells (ASCs). The results indicated that the addition (evenly spread) of ~200 µL of 2 mg/mL bovine collagen type -I (pH adjusted to 7.5) over the MC hydrogel surface at 37 °C is required to improve the ASC adhesion and proliferation. Upon confluence, a continuous monolayer ASC sheet was formed on the surface of the hydrogel system and an intact cell sheet with preserved cell-cell and cell-extracellular matrix was spontaneously and gradually detached when the grown cell sheet was removed from the incubator and exposed to room temperature (~30 °C) within minutes.

  8. (DeCentralization of Public Procurement at the Local Level in the EU

    Directory of Open Access Journals (Sweden)

    Boštjan BREZOVNIK

    2015-10-01

    Full Text Available The so-called decentralization of public procurement in EU Member States is accepted as the most suitable design of the public procurement system, often justifi ed by greater economic effi ciency and by the possibility of boosting the development of small and medium-sized enterprises, which act on the public procurement market as providers of goods, services and works. Despite the existence of highly decentralized public procurement systems which refl ect the decentralization of administrative systems, especially after the recession, there is a stronger tendency for centralization of public procurement in the EU. The so-called aggregation of demand by contracting authorities can be done in order to achieve economies of scale, including lower prices and transaction costs as well as to improve and professionalize the management of procurement procedures (as highlighted in the Directive 2014/24/EU by the European Parliament and the EU Council. However, even in the context of public procurement centralization, local contracting authorities (i.e., public administration authorities and organizations in Member States should be provided with a suffi ciently wide range of possible (centralized organizational structures and contractual (vertical and horizontal public-public partnerships which will allow them to select the most suitable and most economically effective organizational structure for the execution of public procurement.

  9. Computerized engineering logic for procurement and dedication processes

    International Nuclear Information System (INIS)

    Tulay, M.P.

    1996-01-01

    This paper summarizes the work performed for designing the system and especially for calculating on-line expected performance and gives some significant results. In an attempt to better meet the needs of operations and maintenance organizations, many nuclear utility procurement engineering groups have simplified their procedures, developed on-line tools for performing the specification of replacement items, and developed relational databases containing part-level information necessary to automate the procurement process. Although these improvements have helped to reduce the engineering necessary to properly specify and accept/dedicate items for nuclear safety-related applications, a number of utilities have recognized that additional long-term savings can be realized by integrating a computerized logic to assist technical procurement engineering personnel

  10. Procurement model for copper and polymer electrical products

    Directory of Open Access Journals (Sweden)

    S. Sremac

    2013-10-01

    Full Text Available Procurement model for copper and polymer electrical products. Electrical cable structure (wire, insulation, filling and mantle is in accordance with the technical specifications of individual cable components in terms of the incorporated materials. Materials used in cable manufacture are copper, aluminum, rubber and polyvinyl chloride. One of the key issues in managing the flow of goods pertains to the timing of procurement. The combination of the two concepts can take advantage of individual strengths of fuzzy logic and neural networks in hybrid systems of homogeneous structure. The model has high practical significance, as, with minor modifications, it can be applied in any enterprise responsible for managing the goods flows.

  11. Modeling light–tissue interaction in optical coherence tomography systems

    DEFF Research Database (Denmark)

    Andersen, Peter E.; Jørgensen, Thomas Martini; Thrane, Lars

    2015-01-01

    Optical coherence tomography (OCT) performs high-resolution, cross-sectional tomographic imaging of the internal tissue microstructure by measuring backscattered or backreflected light. The scope of this chapter is to present analytical and numerical models that are able to describe light-tissue ...

  12. Flowering of Woody Bamboo in Tissue Culture Systems

    Directory of Open Access Journals (Sweden)

    Jin-Ling Yuan

    2017-09-01

    Full Text Available Flowering and subsequent seed set are not only normal activities in the life of most plants, but constitute the very reason for their existence. Woody bamboos can take a long time to flower, even over 100 years. This makes it difficult to breed bamboo, since flowering time cannot be predicted and passing through each generation takes too long. Another unique characteristic of woody bamboo is that a bamboo stand will often flower synchronously, both disrupting the supply chain within the bamboo industry and affecting local ecology. Therefore, an understanding of the mechanism that initiates bamboo flowering is important not only for biology research, but also for the bamboo industry. Induction of flowering in vitro is an effective way to both shorten the flowering period and control the flowering time, and has been shown for several species of bamboo. The use of controlled tissue culture systems allows investigation into the mechanism of bamboo flowering and facilitates selective breeding. Here, after a brief introduction of flowering in bamboo, we review the research on in vitro flowering of bamboo, including our current understanding of the effects of plant growth regulators and medium components on flower induction and how in vitro bamboo flowers can be used in research.

  13. Status of cask procurement strategy to satisfy DOE/OCRWM requirements

    International Nuclear Information System (INIS)

    Teer, B.R.; Nolan, D.J.; Lake, W.H.

    1993-01-01

    The Nuclear Waste Policy Act requires the development of a safe and efficient system to transport spent nuclear fuel to and within the Federal Waste Management System. This paper describes the DOE/OCRWM strategy to develop and procure a major component of the Transportation System-the transport cask systems. The original initiative to develop high-capacity innovative designs and its current status is described. The follow-on phase to design and procure proven technology cask systems is also discussed

  14. The impact of e-Procurement practice in Indonesia government: A Preliminary Study (The case of Electronic Procurement Service at Bekasi District)

    Science.gov (United States)

    Candra, S.; E Gunawan, F.

    2017-01-01

    In digital economy, government of Indonesia uses the internet to deliver services and to communicate with citizens and organizations. One of applications are e-Procurement and LPSE is a unit to hold the service system of e-Procurement. Procurement of goods and services electronically in addition will increase transparency and accountability, improve market access and healthy competition, as well as improving the efficiency of the procurement process. Based on the background and specific objectives to be achieved, then the research will be viewed from e-Marketplace participation, Trust and its impact on the performance of existing procurement within the institution. Methods of data analysis used in this research is by using analysis of Structural Equation Modelling (SEM) by using the program Partial Least Square (PLS) to examine the relationship between variables. The population used in this study is an enterprise as well as other clients using the system LPSE Bekasi District. There are three part in this study population, namely the provision of a company, customer, and supplier of LPSE users amounted to 60 users. From data analysis, there are one hypothesis that rejected. The implication of this study are implementation of e-procurement and e-marketplace participation giving impact to procurement performance.

  15. Green public procurement

    OpenAIRE

    Dorożyński, Tomasz

    2016-01-01

    Considering environmental protection requirements in business operations may, in the long run, determine if a lasting comparative advantage can be achieved. That is why our textbook, rich in case studies, identifies not only the threats a business may pose to the environment but stresses the ways of reducing its negative impact. It discusses, among other things, the concept of corporate social responsibility, environmental management systems, methods and the importance of eco-labelling goods ...

  16. Avoidable Software Procurements

    Science.gov (United States)

    2012-09-01

    software license, software usage, ELA, Software as a Service , SaaS , Software Asset...PaaS Platform as a Service SaaS Software as a Service SAM Software Asset Management SMS System Management Server SEWP Solutions for Enterprise Wide...delivery of full Cloud Services , we will see the transition of the Cloud Computing service model from Iaas to SaaS , or Software as a Service . Software

  17. 2015 Status Report on Major Defence Equipment Procurements

    Directory of Open Access Journals (Sweden)

    David Perry

    2015-12-01

    Full Text Available Federal elections may be good for democracy, but the campaigns — particularly the lengthy one recently held in Canada — can be crippling for plans to better arm our military. Just before the election was called, there were public signs of important progress being made in what has long been a frustratingly slow and bureaucratically complex procurement process. But then the campaign left the Department of National Defence and other federal departments unable to secure approvals from either a defence minister or the Treasury Board, until the election ended and the new prime minister appointed the current cabinet. There had already been upheaval prior to that: In the first seven months of 2015, the three senior leaders at the Canadian Forces and the Defence Department (including the minister had been replaced, along with many other people critical to the procurement process. In addition, there had been changes in the Public Works Department and the Defence Procurement Strategy Secretariat. Frustrating and disappointing delays have long been a matter of course in Canada’s defence procurement process. In 2014/15, the number of ministerial or Treasury Board approvals to allow projects to proceed was half of that in 2009/10. Yet the demand for approvals has not abated. In addition to the turnover of key figures involved in the procurement and approval process, delays have come from a number of major steps added to the process, making an already lengthy and complex system even more so. To be sure, these steps were added in the pursuit of improved financial management and project management, with the aim of addressing longstanding problems. But it will take years to see if those objectives have been realized. An irony here is that the budget for military procurement has increased. Between 2004 and 2009, the Defence Department’s procurement budget nearly doubled. But the funding was never matched by the capacity to manage it. In 2003, the Material

  18. 75 FR 28589 - Procurement List Proposed Additions and Deletion

    Science.gov (United States)

    2010-05-21

    .... Service Type/Location: Laundry Service, Naval Hospital, 6000 West Hwy 98, Pensacola, FL. NPA: Wiregrass..., FL. Service Type/Location: Laundry Service, Naval Hospital System, 2800 Child Street, Jacksonville... the Procurement List products and services to be furnished by nonprofit agencies employing persons who...

  19. The Challenges Procuring of Safe Abortion Care in Botswana ...

    African Journals Online (AJOL)

    The Challenges Procuring of Safe Abortion Care in Botswana. Stephanie Samantha Smith. Abstract. Botswana's national healthcare system has experienced substantial investment as a result of a growing economy and stable government, and improvements in quality and access are notable. Despite these advances ...

  20. Performance-based contracting in public procurement of developing countries

    NARCIS (Netherlands)

    Ambaw, Baynesagn Asfaw

    2017-01-01

    This research is focused on the application of Performance-based Contracting (PBC) in public procurement system of developing countries. We define five research objectives (ROs) that focus on this common issue. The first objective (RO1) mainly deals with the theory behind and the theoretical

  1. Performance of traditional and direct labour procurement methods ...

    African Journals Online (AJOL)

    The objective was to find out if one has any advantage over the other. Project success determinants like cost, time and quality formed the basis for ... and unit cost of projects were higher for those procured using the traditional contract system.

  2. Vegetables procurement by Asian supermarkets: A transaction cost approach

    NARCIS (Netherlands)

    Ruben, R.; Boselie, D.M.; Hualiang, L.

    2007-01-01

    Purpose - The paper seeks to understand the conditions that motivate Asian supermarkets' choices for vegetable sourcing through wholesale procurement or preferred supplier systems. Design/methodology/approach - Insights from transaction cost theory are used to analyze the evolution of fresh produce

  3. Vegetables procurement by Asian supermarkets: a transaction cost approach

    NARCIS (Netherlands)

    Ruben, R.; Boselie, D.M.; Lu Hualiang,

    2007-01-01

    Purpose - The paper seeks to understand the conditions that motivate Asian supermarkets' choices for vegetable sourcing through wholesale procurement or preferred supplier systems. Design/methodology/approach - Insights from transaction cost theory are used to analyze the evolution of fresh produce

  4. Systemic Lupus Erythematosus and Systemic Autoimmune Connective Tissue Disorders behind Recurrent Diastolic Heart Failure

    Directory of Open Access Journals (Sweden)

    Luis Miguel Blasco Mata

    2012-01-01

    Full Text Available Diastolic heart failure (DHF remains unexplained in some patients with recurrent admissions after full investigation. A study was directed for screening SLE and systemic autoimmune connective tissue disorders in recurrent unexplained DHF patients admitted at a short-stay and intermediate care unit. It was found that systemic autoimmune conditions explained 11% from all of cases. Therapy also prevented new readmissions. Autoimmunity should be investigated in DHF.

  5. Procurement Options for New Renewable Electricity Supply

    Energy Technology Data Exchange (ETDEWEB)

    Kreycik, C. E.; Couture, T. D.; Cory, K. S.

    2011-12-01

    State renewable portfolio standard (RPS) policies require utilities and load-serving entities (LSEs) to procure renewable energy generation. Utility procurement options may be a function of state policy and regulatory preferences, and in some cases, may be dictated by legislative authority. Utilities and LSEs commonly use competitive solicitations or bilateral contracting to procure renewable energy supply to meet RPS mandates. However, policymakers and regulators in several states are beginning to explore the use of alternatives, namely feed-in tariffs (FITs) and auctions to procure renewable energy supply. This report evaluates four procurement strategies (competitive solicitations, bilateral contracting, FITs, and auctions) against four main criteria: (1) pricing; (2) complexity and efficiency of the procurement process; (3) impacts on developers access to markets; and (4) ability to complement utility decision-making processes. These criteria were chosen because they take into account the perspective of each group of stakeholders: ratepayers, regulators, utilities, investors, and developers.

  6. Ethics and regulation in organ procurement research.

    Science.gov (United States)

    Ackerman, Terrence F; Winsett, Rebecca P

    2002-12-01

    This article explores the role of ethics and regulation in human research conducted by organ procurement agencies; basic ethical principles for human research are outlined. Organ procurement agencies are not required to observe federal regulations; however, voluntary adherence will ensure that procurement research is conducted according to current standards of ethical practice. Although most organ procurement research will qualify for exempt status, this determination should be made by an institutional review board. Even if studies qualify for exempt status, there is a moral presumption that informed consent should be sought, unless certain narrow conditions for waiver of consent are satisfied. Finally, when future research utilizing organ procurement records is anticipated, procurement coordinators should provide sufficiently detailed information to families about such plans to permit their advance informed consent to research activities.

  7. The Determinants of the Compliance to Public Procurement Policy Requirements among Public Enterprises in Zimbabwe

    Directory of Open Access Journals (Sweden)

    Maxwell Sandada

    2016-09-01

    Full Text Available Many public entities in Zimbabwe are operating in a very volatile environment characterised by public procurement systems open to abuse. Zimbabwe is one of the first countries in Africa to have a Procurement Act however non-compliance issues are still a challenge. Public procurement scandals have been a hot topic with the media and also with the Report of the Auditor General for the financial year ended December 31, 2014 having picked on a lot of issues relating to non-compliance with procurement regulations in a number of public enterprises. The purpose of the study was to assess the influence selected factors (enforcement, professionalism, political interferences, familiarity with Procurement Act regulations and ethics on compliance to procurement regulations within the public entities. A quantitative survey research approach was used to collect data from 144 public procurement professionals in public entities in Harare, Zimbabwe. SPSS software version 21 was used to process the data that were later analysed through correlation and regression analyses. Familiarity with procurement regulations, enforcement and political interference were found to be statistically significant predictors of compliance. The managerial implications and direction for future research are provided.

  8. Evolution in public procurement and the impact of e-procurement platforms: A case study

    OpenAIRE

    Leal, Pedro Manuel Mariano

    2010-01-01

    A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics The aim of this project is to understand the evolution that occurred in the public procurement due to the new Public Contracts Code that changed the procurement procedures and forced public entities to use electronic procurement platforms. This work is a contribution to the understanding of the main procurement changes with this ...

  9. Services procurement under the WTO’s agreement on government procurement: whither market access?

    OpenAIRE

    Shingal, Anirudh

    2010-01-01

    This paper studies the government procurement of services from foreign suppliers by conducting a statistical analysis of data submitted by Japan and Switzerland to the WTO's Committee on Government Procurement. Using several metrics, the paper examines if the WTO’s Agreement on Government Procurement (GPA) has led to greater market access for foreign suppliers in services procurement. Our results indicate that despite the GPA, the proportions of services contracts awarded to foreigners have d...

  10. Infrastructure procurement skills gap amongst procurement personnel in Nigeria’s public sector

    OpenAIRE

    Mahamadu, A.-M. ed; Manu, P.; Booth, C.; Olomolaiye, P.; Coker, A.; Ibrahim, A. ed; Lamond, J.

    2018-01-01

    Purpose - Procurement of public infrastructure that is fit for purpose partly depends on the competencies of procurement personnel. In many developing countries in Sub-Saharan Africa, including Nigeria, there is a deficit in the quantity and quality of infrastructure and their procurement is further riddled with deficiencies in the capacity of public procuring entities. It is, however, unclear from the extant literature, what are the critical skills development needs of public personnel invol...

  11. Contracting Out Government Procurement Functions: An Analysis

    National Research Council Canada - National Science Library

    Lamm, David; Yoder, Cory

    2008-01-01

    ...)), asked the Naval Postgraduate School (NPS) to analyze the contracting out of procurement functions currently being accomplished by Navy, Marine Corps, and other Department of Defense (DOD) Activities...

  12. The International Experience in Public Procurement

    Directory of Open Access Journals (Sweden)

    Pysmenna Mariia S.

    2017-11-01

    Full Text Available The article is aimed at generalizing the foreign experience of implementing public procurement, analyzing peculiarities of organizational, normative and procedural provision of public procurement in the Member States of the European Union. The relevance of the research topic is due to the need to harmonize the procurement policy of the Government of Ukraine with the international legal framework and with broad political objectives within the European integration strategy. The organizational framework and principles of implementing public procurement in the EU Member States were analyzed. Special attention was paid to normative provision of public procurement by the EU Member States; peculiarities of the use of national or harmonized rules of public procurement in accordance with the amount of the procurement contract; restrictions and conditions for public authorities in the selection of applicants for bidding. Five types of public procurement procedures used in the EU have been characterized, namely: open procedure, limited procedure, negotiation procedure, competitive dialog, electronic auctions. The need to address the social and legal aspects of public procurement in international practice has been substantiated and the possibilities for resolving these problems have been presented.

  13. Vaccine procurement and self-sufficiency in developing countries.

    Science.gov (United States)

    Woodle, D

    2000-06-01

    This paper discusses the movement toward self-sufficiency in vaccine supply in developing countries (and countries in transition to new economic and political systems) and explains special supply concerns about vaccine as a product class. It traces some history of donor support and programmes aimed at self-financing, then continues with a discussion about self-sufficiency in terms of institutional capacity building. A number of deficiencies commonly found in vaccine procurement and supply in low- and middle-income countries are characterized, and institutional strengthening with procurement technical assistance is described. The paper also provides information about a vaccine procurement manual being developed by the United States Agency for International Development (USAID) and the World Health Organization (WHO) for use in this environment. Two brief case studies are included to illustrate the spectrum of existing capabilities and different approaches to technical assistance aimed at developing or improving vaccine procurement capability. In conclusion, the paper discusses the special nature of vaccine and issues surrounding potential integration and decentralization of vaccine supply systems as part of health sector reform.

  14. Handbook for preparation of Individual Procurement Action Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-10-01

    The Procurement and Assistance Data System (PADS) provides a mechanism for collecting, assembling, organizing, and presenting acquisition and assistance data for the Department of Energy (DOE). This handbook and associated documents establish a uniform system to report acquisition/assistance data to PADS for the collection, processing, and dissemination of official statistical data on the Department`s acquisition and assistance actions. The data provides, based on information available at the time of request, a basis for any recurring and special reports to the senior procurement executive, Congress, General Accounting Office (GAO), Federal executive agencies, Office of management and Budget (OMB), and the general public. It provides information for measuring and assessing the extent to which small business firms and small disadvantages business enterprises are sharing in DOE placement, and for other acquisition and assistance policy and management control purposes. The Handbook for the Preparation of the Individual Procurement Action Report (IPAR) has been designed in two sections; Procurement and Financial Assistance to support the individual forms.

  15. International overview of hospital procurement.

    Science.gov (United States)

    Ferrier, Maud; Lariviere, David; Laurent, Claire; Roque, Eric

    2011-01-01

    This article was written by four French hospital director students at the Ecole des Hautes Etudes en Santé Publique (EHESP-School of Public Health) from a study conducted jointly with students at the Grenoble School of Management to present an international overview of hospital procurement methods in ten countries. An analysis of these methods showed that there was a general trend towards group purchasing, with some common aims in terms of costs and performance and some differences in legislation (competition), size of the public sector and centralization or decentralization.

  16. THE IMPACT OF CENTRALIZATION, CORRUPTION AND INSTITUTIONAL QUALITY ON PROCUREMENT PRICES: AN APPLICATION TO PHARMACEUTICAL PURCHASING IN ITALY

    OpenAIRE

    Simona, Baldi; Davide, Vannoni

    2014-01-01

    This paper deals with the open issue about the choice between a centralized versus a decentralized public procurement strategy. Using a unique dataset on tender prices of selected drugs for hospital usage awarded by a sample of 52 Italian local health service providers (ASLs) between 2009 and 2012, we test which procurement system (centralized, decentralized or hybrid) performs better. Controlling for several covariates, we always find that centralized and hybrid procurers pay lower prices as...

  17. 48 CFR 752.225-71 - Local procurement.

    Science.gov (United States)

    2010-10-01

    ... 1997) (a) Local procurement involves the use of appropriated funds to finance the procurement of goods... currency of the cooperating country. (b) All locally-financed procurements must be covered by source/origin...

  18. 75 FR 47550 - Procurement List; Additions

    Science.gov (United States)

    2010-08-06

    ...--Macintosh Apple NSN: MR 473--Fresh Linen NPA: Industries for the Blind, Inc., West Allis, WI Contracting... Service, 5777 S. Aviation Blvd., N. Charleston, SC NPA: Goodwill Industries of Lower South Carolina, Inc... Procurement List. SUMMARY: This action adds products and services to the Procurement List that will be...

  19. 75 FR 22745 - Procurement List Additions

    Science.gov (United States)

    2010-04-30

    ... General Services Administration. Services Service Type/Location: Laundry Services, Alaska VA Healthcare... Procurement List. SUMMARY: This action adds to the Procurement List products and services to be furnished by... concerning capability of qualified nonprofit agencies to provide the products and services and impact of the...

  20. 76 FR 80345 - Procurement List; Additions

    Science.gov (United States)

    2011-12-23

    ... ARMY, W6QL ECC MIAMI DIV, MIAMI, FL. Service Type/Location: Industrial Laundry Service, Bureau of... Procurement List. SUMMARY: This action adds services to the Procurement List that will be provided by... concerning capability of qualified nonprofit agencies to provide the services and impact of the additions on...

  1. 78 FR 48656 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-08-09

    ... Oceanic and Atmospheric Administration, Boulder, CO. Service Type/Location: Laundry Service, US Coast... Additions to the Procurement List. SUMMARY: The Committee is proposing to add products and services to the... required to procure the products and services listed below from nonprofit agencies employing persons who...

  2. 77 FR 27736 - Procurement List Additions

    Science.gov (United States)

    2012-05-11

    ... Research Laboratory, Washington, DC. Service Type/Location: Laundry, Refurbishment, and Warehouse Services... Procurement List. SUMMARY: This action adds products and services to the Procurement List that will be... products and services and impact of the additions on the current or most recent contractors, the Committee...

  3. 77 FR 29596 - Procurement List Proposed Additions

    Science.gov (United States)

    2012-05-18

    .../Location: Laundry Service, Veterans Administration Medical Center (VAMC), (offsite: 1809 W 2nd Avenue... Additions to the Procurement List. SUMMARY: The Committee is proposing to add products and services to the... identified in this notice will be required to procure the products and services listed below from nonprofit...

  4. 75 FR 14576 - Procurement List Additions

    Science.gov (United States)

    2010-03-26

    ... Inspection Service, Minneapolis, MN. M.R. Laundry Products NSN: MR 1103--Heavy Duty Laundry Bag. NSN: MR 1104... procurement list. SUMMARY: This action adds to the Procurement List products and services to be furnished by... products and services and impact of the additions on the current or most recent contractors, the Committee...

  5. 22 CFR 226.44 - Procurement procedures.

    Science.gov (United States)

    2010-04-01

    ... Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.44 Procurement procedures. (a... and assistance, as appropriate, of such organizations as the Small Business Administration and the...

  6. Measuring the effect of Sustainable Public Procurement

    NARCIS (Netherlands)

    Zijp MC; Kok L; Valk E de; DMG; M&V; M&V

    2018-01-01

    Many purchasing services of the Dutch local and central governments, aim to include the effects of products and services on human health and the environment in the procurement process. Sustainable procurement (SP) encompasses more than just price and quality considerations. SP can result, for

  7. 42 CFR 457.940 - Procurement standards.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Procurement standards. 457.940 Section 457.940... Integrity § 457.940 Procurement standards. (a) A State must submit to CMS a written assurance that title XXI... public or private payment rates for comparable services for comparable populations, consistent with...

  8. International Research Study of Public Procurement

    NARCIS (Netherlands)

    Telgen, Jan; Harland, C.; Callender, G.; Harland, C.; Nassimbeni, G.; Schneller, E.

    2012-01-01

    In this chapter we examine the specific issue of public procurement, its importance to local, regional, national, and international economies as evidenced in a unique international comparative research study – the International Research Study of Public Procurement (IRSPP). First the public

  9. 7 CFR 210.21 - Procurement.

    Science.gov (United States)

    2010-01-01

    ... Responsibilities § 210.21 Procurement. (a) General. State agencies and school food authorities shall comply with... violation of law are to be referred to the local, State, or Federal authority that has proper jurisdiction... title are followed. A school food authority may use its own procurement procedures which reflect...

  10. 7 CFR 220.16 - Procurement standards.

    Science.gov (United States)

    2010-01-01

    ... nature. Matters concerning violation of law are to be referred to the local, State or Federal authority... § 3016.60(b) and (c) of this title are followed. The school food authority may use its own procurement procedures which reflect applicable State and local laws and regulations, provided that procurements made...

  11. 78 FR 45183 - Procurement List Additions

    Science.gov (United States)

    2013-07-26

    ... Requirement as aggregated by the General Services Administration. NSN: 7920-00-NIB-0564--Towel, Cleaning, Non... Procurement List. SUMMARY: This action adds a products and services to the Procurement List that will be... presented to it concerning capability of qualified nonprofit agencies to provide the products and services...

  12. How does procurement capability maturity affect e-Procurement adoption and leverage purchasing in supply chain

    Directory of Open Access Journals (Sweden)

    Pongpanga Pongsuwan

    2016-11-01

    Full Text Available This study refers to the research model of Batenburg (2008 which defined procurement functions to six maturity dimensions; strategy, processes, control, organization, information, e-Technology as the starting point and indicates twenty two items to support capability maturity measurement which is called “Procurement Competitive Capability Maturity”(PCCM. This model is used for a company to assess current practices of procurement function and perceives the level of its capabilities. The data collection is from a survey of fifty-two selected procurement organizations in Southeast Asia (SEA countries; from Thailand, Vietnam, Philippines, Indonesia, Malaysia and Singapore. The objective of this study is to demonstrate the significant value of industry type, size of spending and centralized/decentralized procurement that affect procurement capability maturity. The results show that the industry has no relation to the capability maturity; the size of procurement spend has a positive relation to the capability maturity; and the centralized procurement has higher capability maturity than the decentralized. Moreover, this study extends the knowledge of e-Procurement and digital context to leverage procurement processes and visible procurement integration in an organization and across the supply chain.

  13. 48 CFR 619.402 - Small Business Administration procurement center representatives.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Small Business... DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Cooperation with the Small Business Administration 619.402 Small Business Administration procurement center representatives. ...

  14. Procurement of Gun Mounts for the M1A2 Tank

    National Research Council Canada - National Science Library

    1997-01-01

    .... The inquiry resulted from constituent allegations that the Program Executive Officer for Armored Systems Modernization improperly communicated Government information on Army procurement of gun mounts for the MlA2 tank...

  15. Systems genetic analysis of brown adipose tissue function

    Czech Academy of Sciences Publication Activity Database

    Pravenec, Michal; Saba, L. M.; Zídek, Václav; Landa, Vladimír; Mlejnek, Petr; Šilhavý, Jan; Šimáková, Miroslava; Strnad, Hynek; Trnovská, J.; Škop, V.; Hüttl, M.; Marková, I.; Oliyarnyk, O.; Malínská, H.; Kazdová, L.; Smith, H.; Tabakoff, B.

    2018-01-01

    Roč. 50, č. 1 (2018), s. 52-66 ISSN 1094-8341 R&D Projects: GA ČR(CZ) GA13-04420S Institutional support: RVO:67985823 Keywords : brown adipose tissue * coexpression modules * quantitative trait locus * recombinant inbred strains * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Human genetics Impact factor: 3.044, year: 2016

  16. Measuring effects of public procurement of innovation

    DEFF Research Database (Denmark)

    Rolfstam, Max

    Underway for quite some time now has been the discussion on using public procurement as a means to stimulate innovation. However - with some exceptions this has been mainly a conceptual discussion vastly surpassed a corresponding development of appropriate monitoring tools. Also, even if both...... qualitative and quantitative studies have been made, they tend to lack connection to the underlying mechanisms envisaged in the conceptual and/or case based literature. A challenge in this endeavour prevails in the nature of how public procurement of innovation works. Some of the effects rendered may...... about the usefulness of public procurement of innovation are at all realistic and feasible in practice. After reviewing different currently available means to measure both public procurement of innovation measures, as well as public procurement of innovation, the paper outlines a case-based approach...

  17. Public Procurement of Innovation as Endogenous

    DEFF Research Database (Denmark)

    Rolfstam, Max

    Public procurement used as an innovation policy instrument has attracted attention the last decade. It has been argued that public procurement can be used to stimulate innovation from the demand-side. This paper problematizes ‘demand’ understood as a problem defined by a public procurer given...... to potential suppliers to solve. By drawing on a cross-case analysis of two similar projects the paper attempts to explicate an understanding of the role of public procurement of innovation not primarily as a ‘demand-side innovation instrument’, as such thinking might run the risk of ignoring important...... underlying mechanisms critical for success. Instead the paper views public procurement of innovation as an instrument of endogenous- exogenous knowledge conversion....

  18. ONLINE PROCUREMENT IN SME`s

    Directory of Open Access Journals (Sweden)

    Daniela ICHIM

    2017-12-01

    Full Text Available E-Marketplaces are new business places for buying, selling products and services in many industries to support customers. The emergence of business-to-business (B2B in the online environment has opened up opportunities for effective online transactions between businesses. Research in this area is not enough to offer only fragmented perspectives in this area. Therefore, the targeted research problem was designed to investigate how business performance of online B2B purchases can be analyzed. The proposed study focuses on the online procurement in. Specifically, they try to answer questions such as: Does site, product, and vendor characteristics affect the online procurement in? Does online buying experience influence online procurement by? Participants are that use the Internet to procure products or services. Study respondents were SME managers who believe that online procurement will save time, money and effort, reducing costs.

  19. Decentralized Procurement in Light of Strategic Inventories

    DEFF Research Database (Denmark)

    Frimor, Hans; Arya, Anil; Mittendorf, Brian

    2015-01-01

    The centralization versus decentralization choice is perhaps the quintessential organizational structure decision. In the operations realm, this choice is particularly critical when it comes to the procurement function. Why firms may opt to decentralize procurement has been often studied and conf......The centralization versus decentralization choice is perhaps the quintessential organizational structure decision. In the operations realm, this choice is particularly critical when it comes to the procurement function. Why firms may opt to decentralize procurement has been often studied...... and confirmed to be a multifaceted choice. This paper complements existing studies by detailing the trade-offs in the centralization versus decentralization decision in light of firm's decision to cede procurement choices to its individual devisions can help moderate inventory levels and provide a natural salve...

  20. INSTITUTE OF REGULATORY IMPACT ASSESSMENT DEVELOPMENT OF EURASION UNION ENACTMENTS IN THE FIELD OF PUBLIC PROCUREMENT

    Directory of Open Access Journals (Sweden)

    Elena Agapova

    2015-05-01

    Full Text Available Transformation of normative regulation of the public procurement system in the conditions of formation of the Eurasian Union is a very important tool in formation of common markets of goods and services. However, its impact on the development of entrepreneurial activity is ambiguous, which requires the development of regulatory impact assessment instruments of projects normative acts in the field of development of competition policy and procurement system of Eurasian Economy Union.

  1. Biomaterials in co-culture systems: towards optimizing tissue integration and cell signaling within scaffolds.

    Science.gov (United States)

    Battiston, Kyle G; Cheung, Jane W C; Jain, Devika; Santerre, J Paul

    2014-05-01

    Most natural tissues consist of multi-cellular systems made up of two or more cell types. However, some of these tissues may not regenerate themselves following tissue injury or disease without some form of intervention, such as from the use of tissue engineered constructs. Recent studies have increasingly used co-cultures in tissue engineering applications as these systems better model the natural tissues, both physically and biologically. This review aims to identify the challenges of using co-culture systems and to highlight different approaches with respect to the use of biomaterials in the use of such systems. The application of co-culture systems to stimulate a desired biological response and examples of studies within particular tissue engineering disciplines are summarized. A description of different analytical co-culture systems is also discussed and the role of biomaterials in the future of co-culture research are elaborated on. Understanding the complex cell-cell and cell-biomaterial interactions involved in co-culture systems will ultimately lead the field towards biomaterial concepts and designs with specific biochemical, electrical, and mechanical characteristics that are tailored towards the needs of distinct co-culture systems. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Framework for Structuring Procurement Contracts

    Directory of Open Access Journals (Sweden)

    Lena Borg

    2014-12-01

    Full Text Available The aim of this paper is to propose a new framework for structuring contract types and payment methods. Concerning procurement contracts, the first important new feature of this framework is a stepwise structure with three main steps in the contract design: (1 what will be procured—should the contract only include construction, or should it include both construction and operation/maintenance (2 who will do the detailed design of the premise and (3 how many contractors will the client use? The second important new feature of this framework is that both step 2 and step 3 include a continuum of alternatives. Concerning payment methods, the new framework is primarily based on how the specific risks of the project are shared. These frameworks can be useful for policy formulation in that they can help to avoid some problematic ways of formulating policies.

  3. A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

    International Nuclear Information System (INIS)

    Wang, Shang; Larin, K V; Li, Jiasong; Vantipalli, S; Twa, M D; Manapuram, R K; Aglyamov, S; Emelianov, S

    2013-01-01

    Accurate non-invasive assessment of tissue elasticity in vivo is required for early diagnostics of many tissue abnormalities. We have developed a focused air-pulse system that produces a low-pressure and short-duration air stream, which can be used to excite transient surface waves (SWs) in soft tissues. System characteristics were studied using a high-resolution analog pressure transducer to describe the excitation pressure. Results indicate that the excitation pressure provided by the air-pulse system can be easily controlled by the air source pressure, the angle of delivery, and the distance between the tissue surface and the port of the air-pulse system. Furthermore, we integrated this focused air-pulse system with phase-sensitive optical coherence tomography (PhS-OCT) to make non-contact measurements of tissue elasticity. The PhS-OCT system is used to assess the group velocity of SW propagation, which can be used to determine Young’s modulus. Pilot experiments were performed on gelatin phantoms with different concentrations (10%, 12% and 14% w/w). The results demonstrate the feasibility of using this focused air-pulse system combined with PhS-OCT to estimate tissue elasticity. This easily controlled non-contact technique is potentially useful to study the biomechanical properties of ocular and other tissues in vivo. (letter)

  4. Central nervous system tissue heterotopia of the nose: case report and review of the literature

    Science.gov (United States)

    Altissimi, G; Ascani, S; Falcetti, S; Cazzato, C; Bravi, I

    2009-01-01

    Summary The Authors present a case of heterotopic central nervous system tissue observed in an 81-year-old male in the form of an ethmoidal polyp. A review of the literature indicates that this is a rare condition characterised by a connective tissue lesion with astrocytic and oligodendrocytic glial cells, which may be located outside the nasal pyramid in some cases and inside the nasal cavity in others. The most important diagnostic aspect involves differentiating these from meningoencephalocele, which maintains an anatomical connection with central nervous system tissue. Contrast-enhanced imaging is essential for diagnosis, as in cases of heterotopic central nervous system tissue, it will demonstrate that there are no connections with intra-cranial tissue. Endoscopic excision is the treatment of choice. PMID:20161881

  5. A cross-sectional survey of the models in Bihar and Tamil Nadu, India for pooled procurement of medicines.

    Science.gov (United States)

    Chokshi, Maulik; Farooqui, Habib Hasan; Selvaraj, Sakthivel; Kumar, Preeti

    2015-01-01

    In India, access to medicine in the public sector is significantly affected by the efficiency of the drug procurement system and allied processes and policies. This study was conducted in two socioeconomically different states: Bihar and Tamil Nadu. Both have a pooled procurement system for drugs but follow different models. In Bihar, the volumes of medicines required are pooled at the state level and rate contracted (an open tender process invites bidders to quote for the lowest rate for the list of medicines), while actual invoicing and payment are done at district level. In Tamil Nadu, medicine quantities are also pooled at state level but payments are also processed at state level upon receipt of laboratory quality-assurance reports on the medicines. In this cross-sectional survey, a range of financial and non-financial data related to procurement and distribution of medicine, such as budget documents, annual reports, tender documents, details of orders issued, passbook details and policy and guidelines for procurement were analysed. In addition, a so-called ABC analysis of the procurement data was done to to identify high-value medicines. It was observed that Tamil Nadu had suppliers for 100% of the drugs on their procurement list at the end of the procurement processes in 2006, 2007 and 2008, whereas Bihar's procurement agency was only able to get suppliers for 56%, 59% and 38% of drugs during the same period. Further, it was observed that Bihar's system was fuelling irrational procurement; for example, fluconazole (antifungal) alone was consuming 23.4% of the state's drug budget and was being procured by around 34% of the districts during 2008-2009. Also, the ratios of procurement prices for Bihar compared with Tamil Nadu were in the range of 1.01 to 22.50. For 50% of the analysed drugs, the price ratio was more than 2, that is, Bihar's procurement system was procuring the same medicines at more than twice the prices paid by Tamil Nadu. Centralized

  6. Quality assurance aspects of the major procurements for the Large Coil Test Facility

    International Nuclear Information System (INIS)

    Taylor, D.J.; Thompson, P.B.; Ryan, T.L.; Queen, C.C.; Halstead, E.L.; Murphy, J.L.; Wood, R.J.

    1983-01-01

    The Large Coil Test Facility (LCTF) project is comprised of the test stand, supporting cryogenic systems, instrumentation, data acquisition, and utilities necessary for testing the large superconducting coils of the Large Coil Program (LCP). A significant portion of the facility hardware has been obtained through procurement actions with industrial suppliers. This paper addresses the project's experience in formulation and execution of quality assurance (QA) actions relative to several of the major items procured. Project quality assurance planning and specific features related to procurement activities for several of the more specialized test facility components are described. These component procurements include: (1) the coil test stand's major structural item (the bucking post) purchased from foreign industry; (2) fabrication and testing of high-current power supplies; (3) industrial fabrication of specialized instrumentation (voltage-tap signal conditioning modules); and (4) fabrication, installation, and testing of the liquid helium piping system

  7. Heat generation caused by ablation of dental hard tissues with an ultrashort pulse laser (USPL) system.

    Science.gov (United States)

    Braun, Andreas; Krillke, Raphael Franz; Frentzen, Matthias; Bourauel, Christoph; Stark, Helmut; Schelle, Florian

    2015-02-01

    Heat generation during the removal of dental hard tissues may lead to a temperature increase and cause painful sensations or damage dental tissues. The aim of this study was to assess heat generation in dental hard tissues following laser ablation using an ultrashort pulse laser (USPL) system. A total of 85 specimens of dental hard tissues were used, comprising 45 specimens of human dentine evaluating a thickness of 1, 2, and 3 mm (15 samples each) and 40 specimens of human enamel with a thickness of 1 and 2 mm (20 samples each). Ablation was performed with an Nd:YVO4 laser at 1,064 nm, a pulse duration of 9 ps, and a repetition rate of 500 kHz with an average output power of 6 W. Specimens were irradiated for 0.8 s. Employing a scanner system, rectangular cavities of 1-mm edge length were generated. A temperature sensor was placed at the back of the specimens, recording the temperature during the ablation process. All measurements were made employing a heat-conductive paste without any additional cooling or spray. Heat generation during laser ablation depended on the dental hard tissue (enamel or dentine) and the thickness of the respective tissue (p dental hard tissues, heat generation has to be considered. Especially during laser ablation next to pulpal tissues, painful sensations and potential thermal injury of pulp tissue might occur.

  8. Organ procurement in Israel: Lessons for South Africa

    Directory of Open Access Journals (Sweden)

    Bonnie Venter

    2015-11-01

    Full Text Available Modern medicine makes it possible to transplant not only kidneys but any solid organs from one human body to another. Although it is the ideal to harvest organs from a brain-dead person, a kidney or a part of the liver or lung can be transplanted from a living donor to a patient. The majority of countries where organ transplants are performed have a dire need for transplantable organs as the current systems of organ procurement are not obtaining a sufficient amount of transplantable organs. Today’s cruel reality is that many patients are dying while waiting for a transplant. Few nations are able to meet the organ demand through their domestic transplant systems and there is a constant debate about ethical ways of procuring organs for transplantation purposes. This article will scrutinise the Israeli system of organ procurement and it will be compared with the current system of organ donation in South Africa (SA in order to indicate whether SA could possibly, or should, follow the example of Israel to improve its acute donor organ shortage.

  9. Diagnostics of the Enterprise Participation in Electronic Public Procurement: the Aspect of Logistics Management

    Directory of Open Access Journals (Sweden)

    Klyuvak Oksana V.

    2017-03-01

    Full Text Available The aim of the article is to formulate and develop the theoretical and methodological foundations for the functioning of the electronic public procurement system in the logistic environment and develop an approach to determining the level of enterprise readiness for participation in electronic public procurement based on the logistic management of information, financial, information and financial flows, document flows, flows of goods, flows of work and services. The classification of groups of temporary, quantitative, qualitative, cost, technical and technological indicators as well as indicators of the level of readiness of the electronic public procurement system at the macro- and microlevels is proposed. It is recommended to consider the readiness to participate in electronic public procurement and the effectiveness of fulfilling obligations to the customer after the completion of the tender process to be the key indicators for the enterprise. There developed an approach to determining the level of enterprise readiness for participation in electronic public procurement on the basis of a set of criteria related to management of information logistics systems, financial logistics, information and financial logistics, document management, commodity logistics, logistics services and works. Prospects for further research in this direction are development of an approach to financial and economic analysis and evaluation of the effectiveness of the tender security mechanism in the system of electronic public procurement in Ukraine and countries of the European Union.

  10. Thicker three-dimensional tissue from a "symbiotic recycling system" combining mammalian cells and algae.

    Science.gov (United States)

    Haraguchi, Yuji; Kagawa, Yuki; Sakaguchi, Katsuhisa; Matsuura, Katsuhisa; Shimizu, Tatsuya; Okano, Teruo

    2017-01-31

    In this paper, we report an in vitro co-culture system that combines mammalian cells and algae, Chlorococcum littorale, to create a three-dimensional (3-D) tissue. While the C2C12 mouse myoblasts and rat cardiac cells consumed oxygen actively, intense oxygen production was accounted for by the algae even in the co-culture system. Although cell metabolism within thicker cardiac cell-layered tissues showed anaerobic respiration, the introduction of innovative co-cultivation partially changed the metabolism to aerobic respiration. Moreover, the amount of glucose consumption and lactate production in the cardiac tissues and the amount of ammonia in the culture media decreased significantly when co-cultivated with algae. In the cardiac tissues devoid of algae, delamination was observed histologically, and the release of creatine kinase (CK) from the tissues showed severe cardiac cell damage. On the other hand, the layered cell tissues with algae were observed to be in a good histological condition, with less than one-fifth decline in CK release. The co-cultivation with algae improved the culture condition of the thicker tissues, resulting in the formation of 160 μm-thick cardiac tissues. Thus, the present study proposes the possibility of creating an in vitro "symbiotic recycling system" composed of mammalian cells and algae.

  11. 75 FR 49481 - Procurement List; Additions and Deletion

    Science.gov (United States)

    2010-08-13

    ... added to the Procurement List: Services Service Type/Locations: Laundry Service, Atlanta VA Medical...: Additions to and deletion from the Procurement List. SUMMARY: This action adds services to the Procurement... disabilities and deletes a service from the Procurement List previously furnished by such agency. DATES...

  12. 78 FR 21916 - Procurement List; Addition And Deletions

    Science.gov (United States)

    2013-04-12

    ..., the following service is added to the Procurement List: Service Service Type/Location: Laundry Service...: Addition to and Deletions from the Procurement List. SUMMARY: This action adds a service to the Procurement... disabilities, and deletes products and services from the Procurement List previously furnished by such agencies...

  13. 22 CFR 201.23 - Procurement under private sector procedures.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procurement under private sector procedures... § 201.23 Procurement under private sector procedures. (a) General requirements. Procurements under private sector procedures will normally be carried out by importers using negotiated procurement...

  14. Defense Logistics Agency Did Not Fully Implement the Business Enterprise Architecture Procure-to-Pay Business Process in the Enterprise Business System

    Science.gov (United States)

    2014-10-28

    change. Enterprise Business System In August 2000, DLA began developing its Enterprise Resource Planning ( ERP ) system by initiating the Business...the EBS core system. EBS became the ERP system solution supporting DLA nonenergy commodity activities. DLA subsequently enhanced its EBS...capabilities by adding SAP software that supported DLA Enterprise Operational Accounting, real property, and inventory management functions. As part of the

  15. Testing the EFQM model as a framework to measure a company’s procurement performance

    OpenAIRE

    Belvedere, Valeria; Grando, Alberto; Legenvre, Hervé

    2018-01-01

    This paper aims at checking whether the European Foundation for Quality Management (EFQM) Business Excellence Model (BEM) can be used as a reference framework for designing a multi-objective performance measurement system (PMS) for the procurement function. The procurement function is becoming increasingly relevant in the achievement of strategic and economic objectives. Thus, understanding the level of maturity of the practices implemented and identifying improvement opportunities are crucia...

  16. Army Information Technology Procurement: A Business Process Analysis

    Science.gov (United States)

    2015-03-27

    as ‘Other’. For example, funding for a system administrator to perform upkeep on an existing SQL server meets three ‘Item’ criteria and is marked...to perform upkeep on an existing SQL server meets three ‘Item’ criteria and is marked as ‘Other.’ Expected duties are then explained at great...Objective Decision Analysis Tool (AAMODAT) is Value Based Analysis ( VBA ) tool designed for weapon procurement that could serve as a model for

  17. Study of the optical properties of solid tissue phantoms using single and double integrating sphere systems

    CSIR Research Space (South Africa)

    Monem, S

    2015-12-01

    Full Text Available light propagation mechanisms inside the tissues. In this work, two calibration models based on measurements adopting integrating sphere systems have been used to determine the optical properties of the studied solid phantoms. Integrating sphere...

  18. Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage

    NARCIS (Netherlands)

    Rutgers, M.; van Pelt, M.J.; Dhert, W.J.A.; Creemers, L.B.; Saris, D.B.F.

    2010-01-01

    Osteoarthritis and Cartilage Volume 18, Issue 1, January 2010, Pages 12-23 -------------------------------------------------------------------------------- Review Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage M. Rutgers†, M.J.P. van Pelt†,

  19. 40 CFR 30.46 - Procurement records.

    Science.gov (United States)

    2010-07-01

    ... competition when competitive bids or offers are not obtained; and basis for award cost or price. ..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 30.46...

  20. 14 CFR 1260.146 - Procurement records.

    Science.gov (United States)

    2010-01-01

    ... Higher Education, Hospitals, and Other Non-Profit Organizations Procurement Standards § 1260.146... of competition when competitive bids or offers are not obtained, and (c) Basis for award cost or price. ...

  1. 32 CFR 32.46 - Procurement records.

    Science.gov (United States)

    2010-07-01

    ..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 32.46... for lack of competition when competitive bids or offers are not obtained; and (c) Basis for award cost or price. ...

  2. 36 CFR 1210.46 - Procurement records.

    Science.gov (United States)

    2010-07-01

    ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards...) Justification for lack of competition when competitive bids or offers are not obtained, and (c) Basis for award cost or price. ...

  3. 22 CFR 145.46 - Procurement records.

    Science.gov (United States)

    2010-04-01

    ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 145... for lack of competition when competitive bids or offers are not obtained, and (c) basis for award cost or price. ...

  4. 2 CFR 215.46 - Procurement records.

    Science.gov (United States)

    2010-01-01

    ... NON-PROFIT ORGANIZATIONS (OMB CIRCULAR A-110) Post Award Requirements Procurement Standards § 215.46... of competition when competitive bids or offers are not obtained; and (c) Basis for award cost or price. ...

  5. 24 CFR 84.46 - Procurement records.

    Science.gov (United States)

    2010-04-01

    ... EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 84... for lack of competition when competitive bids or offers are not obtained; and (c) Basis for award cost or price. ...

  6. 7 CFR 3019.46 - Procurement records.

    Science.gov (United States)

    2010-01-01

    ...) Justification for lack of competition bids or offers are not obtained, and (c) Basis for award cost or price. ... HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement...

  7. 78 FR 38953 - Procurement List Additions

    Science.gov (United States)

    2013-06-28

    ... Blind or Severely Disabled published notices of proposed additions to the Procurement List. After... Punch, Paper, Desktop, 3-Hole, Adjustable, 11 sheet capacity, Metallic Base, Black Grip. Coverage: A...

  8. 78 FR 12295 - Procurement List; Additions

    Science.gov (United States)

    2013-02-22

    ... published notices of proposed additions to the Procurement List. After consideration of the material..., 508 Compliant, 12 Digit, Portable, Desktop, Battery Operated NPA: MidWest Enterprises for the Blind...

  9. Assessment of procurement methods used for executing ...

    African Journals Online (AJOL)

    Assessment of procurement methods used for executing maintenance works in Lagos state. ... Ethiopian Journal of Environmental Studies and Management ... Others are risk allocation, price competition and flexibility of contract. Finally, better ...

  10. 78 FR 40727 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-07-08

    ... for addition to the Procurement List for production by the nonprofit agencies listed: Products Towel.... 12/BX Cleaner, Brake Parts NSN: 6850-01-167-0678--17 oz. NPA: The Lighthouse for the Blind, St. Louis...

  11. 78 FR 35874 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-06-14

    ... proposed for addition to the Procurement List for production by the nonprofit agencies listed: Products... Cleaner NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC Contracting Activity: Defense...

  12. Industry Analysis for Body Armor Procurement

    National Research Council Canada - National Science Library

    Foust, Coleen; Jenson, Christopher

    2006-01-01

    .... In addition, the Office of Management and Budget has required that each agency create strategic sourcing initiatives, monitor the cost savings and report the results to the Office of Federal Procurement Policy...

  13. Turning the Kaleidoscope: Five Perspectives on Procurement

    DEFF Research Database (Denmark)

    Munkgaard Møller, Morten; Vammen, Søren

    Purpose of this paper The purpose of the paper is to provide a conceptual foundation to enhance the body of knowledge related to procurement and sourcing through a framework consisting of five perspectives. The perspectives are: (1) Strategic, (2) Organizational, (3) Capability, (4) Supplier......, and a (5) Customer Perspectives. The aim is to develop a holistic perspective of procurement by applying these five essential, but very different perspectives in order to achieve a holistic picture of the function. Design/methodology/approach The foundation is derived from various well-established theories...... within the five perspectives. Specifically, procurement was viewed from the perspective of organizational theory, network theory, resource/knowledge based views of the firm, transaction cost theory and various theories within the strategic field of research Findings By viewing procurement through...

  14. ASSESSMENT OF PROCUREMENT METHODS USED FOR ...

    African Journals Online (AJOL)

    Osondu

    2012-10-08

    Oct 8, 2012 ... client/or representatives so as to arrive at a tender figure and other ... client have a great influence on maintenance procurement. ... satisfaction and project success and the ... Construction Industries, and Hotels) top the list.

  15. Government Procurement Agreements and Telecommunications Business

    Directory of Open Access Journals (Sweden)

    Shin-Won Kang

    2001-12-01

    Full Text Available The opening of the telecommunications market is acceleration due to the world trends of deregulation and privatization under the WTO basic telecommunications agreements. Diversification of services and fast and efficient equipment procurement are becoming necessary conditions for the survival of telecommunications operators. However, the issue here is that telecommunications operators are still bound by the GPA (Government Procurement Agreement based on conditions of monopoly even though the procurement market in Korean is open substantially since 1997. Under such conditions, the continued application of the GPA on telecommunications operator who is highly competitive may result in a negative impact on the telecommunications business and quality of telecommunications service by undermining the autonomy of operator and decreasing operator’s procurement competitiveness. Therefore, this study examines the GPA and the issues raised by the agreement, and also attempts to suggest revisions or means of abrogating the unfair GPA with regards to the development and deregulation of the telecommunications business.

  16. Spatial transcriptomics: paving the way for tissue-level systems biology.

    Science.gov (United States)

    Moor, Andreas E; Itzkovitz, Shalev

    2017-08-01

    The tissues in our bodies are complex systems composed of diverse cell types that often interact in highly structured repeating anatomical units. External gradients of morphogens, directional blood flow, as well as the secretion and absorption of materials by cells generate distinct microenvironments at different tissue coordinates. Such spatial heterogeneity enables optimized function through division of labor among cells. Unraveling the design principles that govern this spatial division of labor requires techniques to quantify the entire transcriptomes of cells while accounting for their spatial coordinates. In this review we describe how recent advances in spatial transcriptomics open the way for tissue-level systems biology. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Tissue Equivalent Phantom Design for Characterization of a Coherent Scatter X-ray Imaging System

    Science.gov (United States)

    Albanese, Kathryn Elizabeth

    Scatter in medical imaging is typically cast off as image-related noise that detracts from meaningful diagnosis. It is therefore typically rejected or removed from medical images. However, it has been found that every material, including cancerous tissue, has a unique X-ray coherent scatter signature that can be used to identify the material or tissue. Such scatter-based tissue-identification provides the advantage of locating and identifying particular materials over conventional anatomical imaging through X-ray radiography. A coded aperture X-ray coherent scatter spectral imaging system has been developed in our group to classify different tissue types based on their unique scatter signatures. Previous experiments using our prototype have demonstrated that the depth-resolved coherent scatter spectral imaging system (CACSSI) can discriminate healthy and cancerous tissue present in the path of a non-destructive x-ray beam. A key to the successful optimization of CACSSI as a clinical imaging method is to obtain anatomically accurate phantoms of the human body. This thesis describes the development and fabrication of 3D printed anatomical scatter phantoms of the breast and lung. The purpose of this work is to accurately model different breast geometries using a tissue equivalent phantom, and to classify these tissues in a coherent x-ray scatter imaging system. Tissue-equivalent anatomical phantoms were designed to assess the capability of the CACSSI system to classify different types of breast tissue (adipose, fibroglandular, malignant). These phantoms were 3D printed based on DICOM data obtained from CT scans of prone breasts. The phantoms were tested through comparison of measured scatter signatures with those of adipose and fibroglandular tissue from literature. Tumors in the phantom were modeled using a variety of biological tissue including actual surgically excised benign and malignant tissue specimens. Lung based phantoms have also been printed for future

  18. Five-dimensional ultrasound system for soft tissue visualization.

    Science.gov (United States)

    Deshmukh, Nishikant P; Caban, Jesus J; Taylor, Russell H; Hager, Gregory D; Boctor, Emad M

    2015-12-01

    A five-dimensional ultrasound (US) system is proposed as a real-time pipeline involving fusion of 3D B-mode data with the 3D ultrasound elastography (USE) data as well as visualization of these fused data and a real-time update capability over time for each consecutive scan. 3D B-mode data assist in visualizing the anatomy of the target organ, and 3D elastography data adds strain information. We investigate the feasibility of such a system and show that an end-to-end real-time system, from acquisition to visualization, can be developed. We present a system that consists of (a) a real-time 3D elastography algorithm based on a normalized cross-correlation (NCC) computation on a GPU; (b) real-time 3D B-mode acquisition and network transfer; (c) scan conversion of 3D elastography and B-mode volumes (if acquired by 4D wobbler probe); and (d) visualization software that fuses, visualizes, and updates 3D B-mode and 3D elastography data in real time. We achieved a speed improvement of 4.45-fold for the threaded version of the NCC-based 3D USE versus the non-threaded version. The maximum speed was 79 volumes/s for 3D scan conversion. In a phantom, we validated the dimensions of a 2.2-cm-diameter sphere scan-converted to B-mode volume. Also, we validated the 5D US system visualization transfer function and detected 1- and 2-cm spherical objects (phantom lesion). Finally, we applied the system to a phantom consisting of three lesions to delineate the lesions from the surrounding background regions of the phantom. A 5D US system is achievable with real-time performance. We can distinguish between hard and soft areas in a phantom using the transfer functions.

  19. Utility procurement policies in the USA

    International Nuclear Information System (INIS)

    Lurf, G.; Nikazmerad, N.M.

    1983-01-01

    The subject is discussed under the headings: introduction; market history (historical uranium demand and production in the USA); recent long-term contract activity (expected US reactor demand and uranium production; expected US reactor demand and contracted uranium supplies); utility procurement attitudes; impact of inventories on procurement; current regulatory environment (spot-market price vs average long-term contract price); embargo and imports; conclusion. (U.K.)

  20. Factors influencing global antiretroviral procurement prices.

    Science.gov (United States)

    Wirtz, Veronika J; Forsythe, Steven; Valencia-Mendoza, Atanacio; Bautista-Arredondo, Sergio

    2009-11-18

    Antiretroviral medicines (ARVs) are one of the most costly parts of HIV/AIDS treatment. Many countries are struggling to provide universal access to ARVs for all people living with HIV and AIDS. Although substantial price reductions of ARVs have occurred, especially between 2002 and 2008, achieving sustainable access for the next several decades remains a major challenge for most low- and middle-income countries. The objectives of the present study were twofold: first, to analyze global ARV prices between 2005 and 2008 and associated factors, particularly procurement methods and key donor policies on ARV procurement efficiency; second, to discuss the options of procurement processes and policies that should be considered when implementing or reforming access to ARV programs. An ARV-medicines price-analysis was carried out using the Global Price Reporting Mechanism from the World Health Organization. For a selection of 12 ARVs, global median prices and price variation were calculated. Linear regression models for each ARV were used to identify factors that were associated with lower procurement prices. Logistic regression models were used to identify the characteristics of those countries which procure below the highest and lowest direct manufactured costs. Three key factors appear to have an influence on a country's ARV prices: (a) whether the product is generic or not; (b) the socioeconomic status of the country; (c) whether the country is a member of the Clinton HIV/AIDS Initiative. Factors which did not influence procurement below the highest direct manufactured costs were HIV prevalence, procurement volume, whether the country belongs to the least developed countries or a focus country of the United States President's Emergency Plan For AIDS Relief. One of the principal mechanisms that can help to lower prices for ARV over the next several decades is increasing procurement efficiency. Benchmarking prices could be one useful tool to achieve this.

  1. Best Value Procurement - The Practical Approach

    OpenAIRE

    Storteboom, Arnoud

    2017-01-01

    Traditional procurement methods leave much room for improving risk management and value creation. However, Best Value Procurement (BVP) is designed to increase project value by mitigating risks and increasing the transparency by underscoring the pre-award phase. This shift in paradigm is reached by following a sequence of elements with the principles of transparency, performance information measuring and contractor clarification. The BVP philosophy is developed in the USA. Following is ...

  2. Empirical Analysis of Competition in Procurement Auctions

    OpenAIRE

    Tukiainen, Janne

    2008-01-01

    A vast amount of public services and goods are contracted through procurement auctions. Therefore it is very important to design these auctions in an optimal way. Typically, we are interested in two different objectives. The first objective is efficiency. Efficiency means that the contract is awarded to the bidder that values it the most, which in the procurement setting means the bidder that has the lowest cost of providing a service with a given quality. The second objective is to maximize ...

  3. Multidimensional procurement auctions with unknown weights

    DEFF Research Database (Denmark)

    Greve, Thomas

    This paper studies the consequences of holding a procurement auction when the principal chooses not to show its preferences. My paper extends the procurement auction model of Che (1993) to a situation where both the principal and the agents have private information. Thus, unknown parameters of bo...... gives rise to an analysis of a principal that can not fully commit to the outcome induced by the scoring rule. Therefore, my result apply to contract theory and it’s problems with imperfect commitment....

  4. International public procurement: From scant facts to hard data

    OpenAIRE

    Cernat, Lucian; Kutlina-Dimitrova, Zornitsa

    2015-01-01

    Public procurement is a negotiating area gaining in importance at multilateral and bilateral level, as evidenced by a brief review of procurement provisions in existing trade agreements. The size of procurement spending stands in most developed economies at double-digit percentage points of GDP. However, despite the size and importance of these markets, the factual information available to trade negotiators remains scarce. Although public procurement patterns (e.g. size of procurement markets...

  5. What Is the Status of Indonesian E-Procurement?

    OpenAIRE

    Achmad Nurmandi

    2013-01-01

    E-procurement is an important intrument to prevent corruption in goods and services procurement budget. Indonesia has been implementing the e-procurement project since 2008 based on Presidential Decree. President has stipulating annual order (presidential instruction) has to be obey by all ministries and local governments to procure their budget through r-procurement mechanism. However, untill 2012 fiscal year, this research found that only around 10.26% of central government institution proc...

  6. Procurement management in scientific research and production project

    International Nuclear Information System (INIS)

    Wan Yi

    2008-01-01

    To meet the requirement of development trend of scientific research and production, it is necessary to incorporate the modern procurement management theory in the whole procurement process for the items used in scientific research and production.This paper provided some suggestions to improve the procurement management by introducing the experiences in the application of the modern procurement management methods in the procurement of parts production. (author)

  7. Tissue Renin-Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease

    Directory of Open Access Journals (Sweden)

    Jeppe eSkov

    2014-02-01

    Full Text Available The actions of angiotensin peptides are diverse and locally acting tissue renin-angiotensin systems (RAS are present in almost all tissues of the body. An activated RAS strongly correlates to metabolic disease (e.g. diabetes and its complications and blockers of RAS have been demonstrated to prevent diabetes in humans.Hyperglycemia, obesity, hypertension, and cortisol are well-known risk factors of metabolic disease and all stimulate tissue RAS whereas glucagon-like peptide-1, vitamin D, and aerobic exercise are inhibitors of tissue RAS and to some extent can prevent metabolic disease. Furthermore, an activated tissue RAS deteriorates the same risk factors creating a system with several positive feedback pathways. The primary effector hormone of the RAS, angiotensin II, stimulates reactive oxygen species, induces tissue damage, and can be associated to most diabetic complications. Based on these observations we hypothesize that an activated tissue RAS is the principle cause of metabolic syndrome and type 2 diabetes, and additionally is mediating the majority of the metabolic complications. The involvement of positive feedback pathways may create a self-reinforcing state and explain why metabolic disease initiate and progress. The hypothesis plausibly unify the major predictors of metabolic disease and places tissue RAS regulation in the center of metabolic control.

  8. An evaluation of transit procurement training.

    Science.gov (United States)

    Noland, Robert B; Weiner, Marc D; Klein, Nicholas J; Puniello, Orin D

    2017-04-01

    We evaluated a training course called "Orientation to Transit Procurement", designed and conducted by the National Transit Institute. This course is designed to provide Federal Transit Administration (FTA) grantees an overview of regulations and best practices related to the procurement process. Our objective in conducting the evaluation was to understand how transit agency staff made changes in procurement practices in response to the course training. The evaluation was mixed mode: an Internet survey followed by in-depth interviews with a small group of respondents. Survey respondents were also provided with an open-ended question providing us with additional context for our evaluation. Results show that the training is substantially successful at meeting the goal of improving procurement practices at transit agencies; indeed, most respondents report making changes at their agencies as the proximate result of the training. This was at odds with our exploration of knowledge of procurement topics, as most respondents gave inaccurate answers on multiple-choice "knowledge questions". This may have been due to question structure or, more likely, the nature of online surveys. Suitable training on the procurement of information technology was also a main concern. The lack of training in this area is indicative of the broader challenge facing public transit agencies in how to incorporate new forms of technology into their existing practices and bureaucratic structures. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. The skeletal vascular system - Breathing life into bone tissue.

    Science.gov (United States)

    Stegen, Steve; Carmeliet, Geert

    2017-08-26

    During bone development, homeostasis and repair, a dense vascular system provides oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system in bone is the serial organization of two capillary systems, each typified by specific morphological and physiological features. Especially the arterial capillaries mediate the growth of the bone vascular system, serve as a niche for skeletal and hematopoietic progenitors and couple angiogenesis to osteogenesis. Endothelial cells and osteoprogenitor cells interact not only physically, but also communicate to each other by secretion of growth factors. A vital angiogenic growth factor is vascular endothelial growth factor and its expression in skeletal cells is controlled by osteogenic transcription factors and hypoxia signaling, whereas the secretion of angiocrine factors by endothelial cells is regulated by Notch signaling, blood flow and possibly hypoxia. Bone loss and impaired fracture repair are often associated with reduced and disorganized blood vessel network and therapeutic targeting of the angiogenic response may contribute to enhanced bone regeneration. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Tissue P Systems With Channel States Working in the Flat Maximally Parallel Way.

    Science.gov (United States)

    Song, Bosheng; Perez-Jimenez, Mario J; Paun, Gheorghe; Pan, Linqiang

    2016-10-01

    Tissue P systems with channel states are a class of bio-inspired parallel computational models, where rules are used in a sequential manner (on each channel, at most one rule can be used at each step). In this work, tissue P systems with channel states working in a flat maximally parallel way are considered, where at each step, on each channel, a maximal set of applicable rules that pass from a given state to a unique next state, is chosen and each rule in the set is applied once. The computational power of such P systems is investigated. Specifically, it is proved that tissue P systems with channel states and antiport rules of length two are able to compute Parikh sets of finite languages, and such P systems with one cell and noncooperative symport rules can compute at least all Parikh sets of matrix languages. Some Turing universality results are also provided. Moreover, the NP-complete problem SAT is solved by tissue P systems with channel states, cell division and noncooperative symport rules working in the flat maximally parallel way; nevertheless, if channel states are not used, then such P systems working in the flat maximally parallel way can solve only tractable problems. These results show that channel states provide a frontier of tractability between efficiency and non-efficiency in the framework of tissue P systems with cell division (assuming P ≠ NP ).

  11. Improving the policy of public procurements for development of science cities: agent-oriented modeling and scenario analysis

    Directory of Open Access Journals (Sweden)

    Vladimir I. Abramov

    2018-03-01

    Full Text Available Objective to assess the impact of policy change scenarios in the sphere of public procurements on the development of science cities. Methods simulation modeling agentoriented modeling. Results depressive trends of singleindustry townsrsquo development are one of the key problems in the development of Russia. At the same time the procedure for identifying suppliers proposed by the system of public procurements does not imply mechanisms that would favor the development of science cities. The article analyzes the approaches to estimate the effectiveness of the public procurements system. It is determined that the agentoriented approach is one of the most promising methods of public procurements management. Through simulation modeling in particular agentoriented approach the article presents the results of scenario experiments. It is established that public procurements can act not only as an instrument of effective expenditure of budgetary funds but also as a mechanism of economic development of territories. Although the presented experiments showed a decrease in the level of savings as a result of competitive procedures additionalnbsp socioeconomic effects were achieved due to the localization of procurements participants in the science citiesrsquo territory. Among other things the scenarios suggest reduction of transportation costs and consequently the traffic flow between Moscow and science cities which would help to reduce the load on the transport networks of megacities. Scientific novelty for the first time it was shown that the tool of public procurements can serve for stimulation and maintenance of the development of science cities and singleindustry towns and become a key factor in their development. The agentoriented model of the public procurements system functioning by the example of Zhukovskiy science city was developed which allows quantitative estimation of the consequences of introducing various mechanisms for improving the

  12. Tissue distribution of enrofloxacin after intramammary or simulated systemic administration in isolated perfused sheep udders.

    Science.gov (United States)

    López Cadenas, Cristina; Fernández Martínez, Nélida; Sierra Vega, Matilde; Diez Liébana, Maria J; Gonzalo Orden, Jose M; Sahagún Prieto, Ana M; García Vieitez, Juan J

    2012-11-01

    To determine the tissue distribution of enrofloxacin after intramammary or simulated systemic administration in isolated perfused sheep udders by measuring its concentration at various sample collection sites. 26 udders (obtained following euthanasia) from 26 healthy lactating sheep. For each isolated udder, 1 mammary gland was perfused with warmed, gassed Tyrode solution. Enrofloxacin (1 g of enrofloxacin/5 g of ointment) was administered into the perfused gland via the intramammary route or systemically via the perfusion fluid (equivalent to a dose of 5 mg/kg). Samples of the perfusate were obtained every 30 minutes for 180 minutes; glandular tissue samples were obtained at 2, 4, 6, and 8 cm from the teat base after 180 minutes. The enrofloxacin content of the perfusate and tissue samples was analyzed via high-performance liquid chromatography with UV detection. After intramammary administration, maximun perfusate enrofloxacin concentration was detected at 180 minutes and, at this time, mean tissue enrofloxacin concentration was detected and mean tissue enrofloxacin concentration was 123.80, 54.48, 36.72, and 26.42 μg/g of tissue at 2, 4, 6, and 8 cm from the teat base, respectively. Following systemic administration, perfusate enrofloxacin concentration decreased with time and, at 180 minutes, tissue enrofloxacin concentrations ranged from 40.38 to 35.58 μg/g of tissue. By 180 minutes after administration via the intramammary or systemic route in isolated perfused sheep mammary glands, mean tissue concentration of enrofloxacin was greater than the minimum inhibitory concentration required to inhibit growth of 90% of many common mastitis pathogens in sheep. Use of either route of administration (or in combination) appears suitable for the treatment of acute mastitis in sheep.

  13. Lessons learnt from the use of relationship-based procurement methods in Australia: clients’ perspectives

    Directory of Open Access Journals (Sweden)

    Farshid Rahmani

    2016-06-01

    Full Text Available This paper aims to review the use of various construction procurement systems and present the development of Relationship-Based Procurement (RBP Methods currently in use within the Australian construction industry. Therefore, this paper provides the historical development of procurement briefly and then focuses on the adoption of Relationship-Based Procurement (RBP approaches in the Australian construction industry to investigate the future direction of the collaborative project procurement arrangements. Semi-structured interviews with high-level managers in the Australian state government organizations have been conducted to answer the research question. A discussion has been presented about the potential future tendency of the industry in adopting a RBP. The findings suggest that even though relationship based procurement systems offer significant benefits; they are not popular among the public sector decision makers because of inability to demonstrate Value for Money (VfM propositions for public projects. Other reasons which may cause a move away from using RBPs in the future include the need for managers to fully engage throughout the project, and the lack of collaborative environment within the construction industry in general.

  14. A precision isotonic measuring system for isolated tissues.

    Science.gov (United States)

    Mellor, P M

    1984-12-01

    An isotonic measuring system is described which utilizes an angular position transducer of the linear differential voltage transformer type. Resistance to corrosion, protection against the ingress of solutions, and ease of mounting and setting up were the mechanical objectives. Accuracy, linearity, and freedom from drift were essential requirements of the electrical specification. A special housing was designed to accommodate the transducer to overcome these problems. A control unit incorporating a power supply and electronic filtering components was made to serve up to four such transducers. The transducer output voltage is sufficiently high to drive directly even low sensitivity chart recorders. Constructional details and a circuit diagram are included. Fifty such transducers have been in use for up to four years in these laboratories. Examples of some of the published work done using this transducer system are referenced.

  15. Multicompartment Drug Release System for Dynamic Modulation of Tissue Responses.

    Science.gov (United States)

    Morris, Aaron H; Mahal, Rajwant S; Udell, Jillian; Wu, Michelle; Kyriakides, Themis R

    2017-10-01

    Pharmacological modulation of responses to injury is complicated by the need to deliver multiple drugs with spatiotemporal resolution. Here, a novel controlled delivery system containing three separate compartments with each releasing its contents over different timescales is fabricated. Core-shell electrospun fibers create two of the compartments in the system, while electrosprayed spheres create the third. Utility is demonstrated by targeting the foreign body response to implants because it is a dynamic process resulting in implant failure. Sequential delivery of a drug targeting nuclear factor-κB (NF-κB) and an antifibrotic is characterized in in vitro experiments. Specifically, macrophage fusion and p65 nuclear translocation in the presence of releasate or with macrophages cultured on the surfaces of the constructs are evaluated. In addition, releasate from pirfenidone scaffolds is shown to reduce transforming growth factor-β (TGF-β)-induced pSMAD3 nuclear localization in fibroblasts. In vivo, drug eluting constructs successfully mitigate macrophage fusion at one week and fibrotic encapsulation in a dose-dependent manner at four weeks, demonstrating effective release of both drugs over different timescales. Future studies can employ this system to improve and prolong implant lifetimes, or load it with other drugs to modulate other dynamic processes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Strategies for success among OPOs: a study of three organ procurement organizations.

    Science.gov (United States)

    Shafer, T J; Kappel, D F; Heinrichs, D F

    1997-03-01

    Productivity among organ procurement organizations varies widely in the US, and the pressure to determine critical success factors increases as the organ pool shrinks and managed care expands. This study compared three successful organ procurement organizations, identified commonalities among them in cost of doing business, and examined direct and indirect expenses, staffing, specialized requestor programs, and professional and public education programs. The three organ procurement organizations were chosen because of their performance in terms of donors per million population, complexity, and size. The following key indicators were compared and analyzed: annual operating budget, size and composition of staff, funds and resources invested in professional education versus public education, tissue recovery operations, results of minority initiatives, and employee compensation programs.

  17. Informatics-guided procurement of patient samples for biomarker discovery projects in cancer research.

    Science.gov (United States)

    Suh, K Stephen; Remache, Yvonne K; Patel, Jalpa S; Chen, Steve H; Haystrand, Russell; Ford, Peggy; Shaikh, Anadil M; Wang, Jian; Goy, Andre H

    2009-02-01

    Modern cancer research for biomarker discovery program requires solving several tasks that are directly involved with patient sample procurement. One requirement is to construct a highly efficient workflow on the clinical side for the procurement to generate a consistent supply of high quality samples for research. This undertaking needs a network of interdepartmental collaborations and participations at various levels, including physical human interactions, information technology implementations and a bioinformatics tool that is highly effective and user-friendly to busy clinicians and researchers associated with the sample procurement. Collegial participation that is sequential but continual from one department to another demands dedicated bioinformatics software coordinating between the institutional clinic and the tissue repository facility. Participants in the process include admissions, consenting process, phlebotomy, surgery center and pathology. During this multiple step procedures, clinical data are collected for detailed analytical endpoints to supplement logistics of defining and validating the discovery of biomarkers.

  18. Co-culture systems-based strategies for articular cartilage tissue engineering.

    Science.gov (United States)

    Zhang, Yu; Guo, Weimin; Wang, Mingjie; Hao, Chunxiang; Lu, Liang; Gao, Shuang; Zhang, Xueliang; Li, Xu; Chen, Mingxue; Li, Penghao; Jiang, Peng; Lu, Shibi; Liu, Shuyun; Guo, Quanyi

    2018-03-01

    Cartilage engineering facilitates repair and regeneration of damaged cartilage using engineered tissue that restores the functional properties of the impaired joint. The seed cells used most frequently in tissue engineering, are chondrocytes and mesenchymal stem cells. Seed cells activity plays a key role in the regeneration of functional cartilage tissue. However, seed cells undergo undesirable changes after in vitro processing procedures, such as degeneration of cartilage cells and induced hypertrophy of mesenchymal stem cells, which hinder cartilage tissue engineering. Compared to monoculture, which does not mimic the in vivo cellular environment, co-culture technology provides a more realistic microenvironment in terms of various physical, chemical, and biological factors. Co-culture technology is used in cartilage tissue engineering to overcome obstacles related to the degeneration of seed cells, and shows promise for cartilage regeneration and repair. In this review, we focus first on existing co-culture systems for cartilage tissue engineering and related fields, and discuss the conditions and mechanisms thereof. This is followed by methods for optimizing seed cell co-culture conditions to generate functional neo-cartilage tissue, which will lead to a new era in cartilage tissue engineering. © 2017 Wiley Periodicals, Inc.

  19. Evaluation of impedance on biological Tissues using automatic control measurement system

    Energy Technology Data Exchange (ETDEWEB)

    Kil, Sang Hyeong; Shin, Dong Hoon; Lee, Seong Mo [Pusan National University, Yangsan (Korea, Republic of); Lee, Moo Seok; Kim, Sang Sik [Pusan National University, Busan (Korea, Republic of); Kim, Gun FDo; Lee, Jong Kyu [Pukyung National University, Busan (Korea, Republic of)

    2015-08-15

    Each biological tissue has endemic electrical characteristics owing to various differences such as those in cellular arrangement or organization form. The endemic electrical characteristics change when any biological change occurs. This work is a preliminary study surveying the changes in the electrical characteristics of biological tissue caused by radiation exposure. For protection against radiation hazards, therefore the electrical characteristics of living tissue were evaluated after development of the automatic control measurement system using LabVIEW. No alteration of biological tissues was observed before and after measurement of the electrical characteristics, and the biological tissues exhibited similar patterns. Through repeated measurements using the impedance/gain-phase analyzer, the coefficient of variation was determined as within 10%. The reproducibility impedance phase difference in electrical characteristics of the biological tissue did not change, and the tissue had resistance. The absolute value of impedance decreased constantly in proportion to the frequency. It has become possible to understand the electrical characteristics of biological tissues through the measurements made possible by the use of the developed.

  20. Evaluation of impedance on biological Tissues using automatic control measurement system

    International Nuclear Information System (INIS)

    Kil, Sang Hyeong; Shin, Dong Hoon; Lee, Seong Mo; Lee, Moo Seok; Kim, Sang Sik; Kim, Gun FDo; Lee, Jong Kyu

    2015-01-01

    Each biological tissue has endemic electrical characteristics owing to various differences such as those in cellular arrangement or organization form. The endemic electrical characteristics change when any biological change occurs. This work is a preliminary study surveying the changes in the electrical characteristics of biological tissue caused by radiation exposure. For protection against radiation hazards, therefore the electrical characteristics of living tissue were evaluated after development of the automatic control measurement system using LabVIEW. No alteration of biological tissues was observed before and after measurement of the electrical characteristics, and the biological tissues exhibited similar patterns. Through repeated measurements using the impedance/gain-phase analyzer, the coefficient of variation was determined as within 10%. The reproducibility impedance phase difference in electrical characteristics of the biological tissue did not change, and the tissue had resistance. The absolute value of impedance decreased constantly in proportion to the frequency. It has become possible to understand the electrical characteristics of biological tissues through the measurements made possible by the use of the developed.

  1. Cornea procurement, preservation and transplantation

    International Nuclear Information System (INIS)

    Hudson Silva

    1999-01-01

    Our experience on this subject is 40 years and we have seen the developments everywhere during this total period. Cornea procurement has been an unsurmountable problem in a large number of countries, mostly due to social and cultural reasons. The requirements for a simple eye bank to manage the supply for a local hospital are minimal. What is the most important is the donor base. In Sri Lanka nurtured in the traditions of Theravada Buddhism the donor base was easy to prepare. We had no difficulties with Christians and Hindus. For Muslims there are Fatwas in favour of donating eyes. But we always found them to be a reluctant group. But in predominantly Muslim countries, it is imperative that social workers should take up this issue, so those thousands may be helped. In all areas where attempts are made to procure comeas, it is important to have a day-and-night service available at short notice to collect any eyes offered. A trained technician with sterilised instruments to obtain eyes and blood sample must be available at a convenient location preferably in a large hospital. Even in places where the supply is infrequent, it is essential to have the readily-sterilised instruments to proceed to a donor site at short notice. To get eyes, general publicity in mass media alone is not sufficient. Such publicity makes people aware of the need for donor eyes and where a technician/doctor is available. What is more important is to canvass personally after a person has died For this purpose trained social workers may be employed, or the technician can do the motivation, as we do in Sri Lanka. Once eyes are removed, it is essential to pay careful attention to the appearance of the cadaver. It should not (and need not) cause any deformity as such event has a profound negative effect on the campaign. Many different preservation methods have been used over the years. Mc Carey-Kaufmann (MK) medium has been the standard for many years, and gives a life span of 4-5 days. The formula

  2. A Lindenmayer system-based approach for the design of nutrient delivery networks in tissue constructs

    Energy Technology Data Exchange (ETDEWEB)

    Yasar, Ozlem; Starly, Binil [School of Industrial Engineering, University of Oklahoma, Norman, OK 73019 (United States); Lan, S-F [University of Oklahoma Bioengineering Center, University of Oklahoma, Norman, OK 73019 (United States)

    2009-12-15

    Large thick tissue constructs have reported limited success primarily due to the inability of cells to survive deep within the scaffold. Without access to adequate nutrients, cells placed deep within the tissue construct will die out, leading to non-uniform tissue regeneration. Currently, there is a necessity to design nutrient conduit networks within the tissue construct to enable cells to survive in the matrix. However, the design of complex networks within a tissue construct is challenging. In this paper, we present the Lindenmayer system, an elegant fractal-based language algorithm framework, to generate conduit networks in two- and three-dimensional architecture with several degrees of complexity. The conduit network maintains a parent-child relationship between each branch of the network. Several L-system parameters have been studied-branching angle, branch length, ratio of parent to child branch diameter, etc-to simulate several architectures under a given L-system notation. We have also presented a layered manufacturing-based UV-photopolymerization process using the Texas Instruments DLP(TM) system to fabricate the branched structures. This preliminary work showcases the applicability of L-system-based construct designs to drive scaffold fabrication systems.

  3. A Lindenmayer system-based approach for the design of nutrient delivery networks in tissue constructs

    International Nuclear Information System (INIS)

    Yasar, Ozlem; Starly, Binil; Lan, S-F

    2009-01-01

    Large thick tissue constructs have reported limited success primarily due to the inability of cells to survive deep within the scaffold. Without access to adequate nutrients, cells placed deep within the tissue construct will die out, leading to non-uniform tissue regeneration. Currently, there is a necessity to design nutrient conduit networks within the tissue construct to enable cells to survive in the matrix. However, the design of complex networks within a tissue construct is challenging. In this paper, we present the Lindenmayer system, an elegant fractal-based language algorithm framework, to generate conduit networks in two- and three-dimensional architecture with several degrees of complexity. The conduit network maintains a parent-child relationship between each branch of the network. Several L-system parameters have been studied-branching angle, branch length, ratio of parent to child branch diameter, etc-to simulate several architectures under a given L-system notation. We have also presented a layered manufacturing-based UV-photopolymerization process using the Texas Instruments DLP(TM) system to fabricate the branched structures. This preliminary work showcases the applicability of L-system-based construct designs to drive scaffold fabrication systems.

  4. The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?

    Science.gov (United States)

    Kulkarni, Onkar P; Lichtnekert, Julia; Anders, Hans-Joachim; Mulay, Shrikant R

    2016-01-01

    Inflammation is a response to infections or tissue injuries. Inflammation was once defined by clinical signs, later by the presence of leukocytes, and nowadays by expression of "proinflammatory" cytokines and chemokines. But leukocytes and cytokines often have rather anti-inflammatory, proregenerative, and homeostatic effects. Is there a need to redefine "inflammation"? In this review, we discuss the functions of "inflammatory" mediators/regulators of the innate immune system that determine tissue environments to fulfill the need of the tissue while regaining homeostasis after injury.

  5. Artificial neural net system for interactive tissue classification with MR imaging and image segmentation

    International Nuclear Information System (INIS)

    Clarke, L.P.; Silbiger, M.; Naylor, C.; Brown, K.

    1990-01-01

    This paper reports on the development of interactive methods for MR tissue classification that permit mathematically rigorous methods for three-dimensional image segmentation and automatic organ/tumor contouring, as required for surgical and RTP planning. The authors investigate a number of image-intensity based tissue- classification methods that make no implicit assumptions on the MR parameters and hence are not limited by image data set. Similarly, we have trained artificial neural net (ANN) systems for both supervised and unsupervised tissue classification

  6. Networking for knowledge capacity building of procurement professionals in Ghana

    Directory of Open Access Journals (Sweden)

    Kissi Ernest

    2016-12-01

    Full Text Available The role of public procurement professionals in achieving value for money in public procurement activities is widely acknowledged around the globe. This has inspired the organisation of training programmes and workshops for procurement professionals, particularly those in developing countries in order to hone their knowledge and skills for proper management of government projects. This paper sought to explore the opportunities in networking for knowledge capacity building of procurement professionals in Ghana. The study adopted quantitative research methods for both data collection and analysis. The paper revealed that professional networking can offer procurement professionals the opportunity to acquire new knowledge from external professionals, know global trends about procurement practice, and obtain new information from other institutions about procurement. It is recommended that a platform that can support a network of procurement professionals in Ghana should be developed in order to ensure effective interaction and communication among procurement professionals for their capacity building.

  7. Donor conversion and procurement failure: the fate of our potential organ donors.

    Science.gov (United States)

    Branco, Bernardino C; Inaba, Kenji; Lam, Lydia; Salim, Ali; Barmparas, Galinos; Teixeira, Pedro G R; Talving, Peep; Demetriades, Demetrios

    2011-02-01

    Donor availability remains the primary limiting factor for organ transplantation today. The purpose of this study was to examine the causes of procurement failure amongst potential organ donors. After Institutional Review Board approval, all surgical intensive care unit (SICU) patients admitted to the LAC+USC Medical Center from 01/2006 to 12/2008 who became potential organ donors were identified. Demographics, clinical data, and procurement data were abstracted. In non-donors, the causes of procurement failure were documented. During the 3-year study period, a total of 254 patients were evaluated for organ donation. Mean age was 44.8±18.7 years; 191 (75.2%) were male, 136 (53.5%) were Hispanic, and 148 (58.3%) were trauma patients. Of the 254 patients, 116 (45.7%) were not eligible for donation: 34 had multi-system organ failure, 24 did not progress to brain death and had support withdrawn, 18 had uncontrolled sepsis, 15 had malignancy, 6 had human immunodeficiency virus or hepatitis B or C, and 19 patients had other contraindications to organ donation. Of the remaining 138 eligible patients, 83 (60.2%) did not donate: 56 because the family denied consent, 9 by their own choice. In six, next of kin could not be located, five died because of hemodynamic instability before organ procurement was possible, four had organs that could not be placed, and three had their organs declined by the organ procurement organization. The overall consent rate was 57.5% (n=67). From the 55 donors, 255 organs were procured (yield 4.6 organs/donor). Of all patients screened for organ donation, only a fifth actually donated. Denial of consent was the major potentially preventable cause of procurement failure, whereas hemodynamic instability accounted for only a small percentage of donor losses. With such low conversion rates, the preventable causes of procurement failure warrant further study.

  8. Indigenous procurement of nuclear components at Tarapur (Paper No. 013)

    International Nuclear Information System (INIS)

    Verma, D.K.; Moss, V.J.

    1987-02-01

    The Tarapur Atomic Power Station (TAPS) was the first nuclear power station in developing countries and the first twin BWR units in the world. The Station has two units of boiling water reactor of very early design; along with its turbo-generator and supporting systems; constructed by M/s. I.G.E. on turnkey basis. Based on vendor recommendations initial operating spares for 5 years of operation were purchased from original equipment manufacturers. This does not call for the participation of the ultimate user; in the design, development, manufacture and quality control and user's participation remained confined to assemble the acceptable component(s) procured from original source in the assembly. As early as 1972, Plant initiated indigenising the nuclear components by gradually increasing the contribution of indigenous industry with due participation of the departmental agencies. Procurement of nuclear components requires development of engineering to an extent; where interphase communication between TAPS and counterpart indigenous industry is practicable to motivate them. Feedback from operation and maintenance practices is also utilised effectively. For some of the components initial sample were developed at TAPS and subsequently bulk fabrication was taken by industry. This paper describes manufacture, quality control during the process of manufacture and procurement of indigenous nuclear components relevant to Tarapur Atomic Power Station. (author)

  9. Micro fluidic System for Culturing and Monitoring of Neuronal Cells and Tissue

    DEFF Research Database (Denmark)

    Bakmand, Tanya; Waagepetersen, Helle S.

    The aim of this Ph.D. project was to combine experience within cell and tissue culturing, electrochemistry and microfabrication in order to develop an in vivo-like fluidic culturing platform, challenging the traditional culturing methods. The first goal was to develope a fluidic system for cultur...... with mass production. The last part of this thesis also includes perspectives on how to expand the latest designed device to facilitate culturing of tissue and co-culturing of cells....

  10. PUBLIC PROCUREMENT IN GHANA: THE IMPLEMENTATION CHALLENGES TO THE PUBLIC PROCUREMENT LAW 2003 (ACT 663

    Directory of Open Access Journals (Sweden)

    Ameyaw, Collins

    2012-08-01

    Full Text Available The purpose of this study was to identify various implementation bottlenecks to the Ghana Public Procurement Law 2003 (Act 663. The study adopted multiple research approaches, including; review of relevant literature, interviews and questionnaire survey of 49 District Assemblies and Metropolitan and Municipal Assemblies in the Ashanti and Brong Ahafo Regions of Ghana. The study identified low capacity of procurement professionals, low interaction between procurement entities and Public Procurement Authority (PPA, deliberate controlling of competition, non-compliance with provisions of the law, splitting of contracts into smaller lots, lack of funds and non-cooperativeness of suppliers, as the major challenges militating against the implementation of the Public Procurement Law.

  11. FAKTOR-FAKTOR YANG MEMENGARUHI PROCUREMENT FRAUD: SEBUAH KAJIAN DARI PERSPEKTIF PERSEPSIAN AUDITOR EKSTERNAL

    Directory of Open Access Journals (Sweden)

    Zulaikha Zulaikha

    2016-12-01

    Full Text Available This study examines factors affecting fraud in the procurement of government’s goods and services from the independent auditor’s point of view. Based on fraud triangles and theory of planned behavior, this study proposes seven hypotheses which were tested using structural equation model (SEM-partial least square. This study used primary data gathered by survey to auditors of Audit Board of the Republic of Indonesia in its head office and several selected representative offices. Respondents were asked to provide their answer/perception for questions in questionnaire regarding factors influencing the procurement fraud of government’s goods and services. The results show that the procurement frauds are significantly influenced by weaknesses in procurement system, lack of procurement committee's quality, and the intention to engage fraud. Furthermore, the intention to engage fraud are influenced by attitude, subjective norms, and the perceived behavioral control. These findings suggest that procurement frauds are associated with individual factors as rationalization and opportunities. These factors could be considered when designing internal control structure to restrain fraud behavior.

  12. Procurement selection criteria for projects in the public sector: evidence from Nigeria

    Directory of Open Access Journals (Sweden)

    Richard Ajayi Jimoh

    2016-12-01

    Full Text Available The selection of suitable procurement practice for construction projects is a very complex and demanding tasks for stakeholders in the construction industry. In spite of the overabundance of techniques and tools accessible to the stakeholders in selecting an appropriate procurement method, clients are faced with the decision as to which of the selection criteria can be adopted for a given construction project to achieve project goals and objectives. This paper focused on evaluating the existing procurement methods being practised in the Nigerian construction industry with a view to identifying and establishing the parameters for selection that will improve contract delivery systems. In this research, quantitative approach was used to collect data from 420 contractors, consultants and clients based in the Federal Capital Territory, Abuja where large numbers of building projects are being procured. The findings revealed six most commonly considered criteria and deduced that, the quality, cost and duration of the project determines the type of procurement method to adopt. It is therefore stated that in selecting any particular procurement method for building construction projects, the complexity of such project should be clearly defined and the other performance indicators be given adequate consideration for a successful project delivery that will enhance the achievement of the client’s goal.

  13. E-Procurement Service Quality in Malaysia

    Directory of Open Access Journals (Sweden)

    Sharifah Latifah binti Syed A. Kadir

    2016-12-01

    Full Text Available The electronic government in Malaysia has fully adopted and developed the applications and practices of ICTs, in order to provide better online services in enhancing the credibility of government. In order to understand service quality issues within this new delivery channel, this paper investigates E-procurement portal/websites’ through the use of E-Service-Quality (E-S-QUAL and E-Recovery Service-Quality (E- RecS-QUAL scales by using a questionnaire survey distributed to 400 respondents. The collected data was analysed using Smart PLS 3.0 to test the relationship between efficiency, system availability and privacy, responsiveness and contact. The results show that both E-S-QUAL and E-RecS-QUAL strongly influence perceived service quality and behavioural intentions. In addition, the evidence of perceived ser- vice quality on its role as a mediator of was significant. The findings constitute an empirical contribution to the extension of literature in the application of the electronic service quality.

  14. The necessity of a theory of biology for tissue engineering: metabolism-repair systems.

    Science.gov (United States)

    Ganguli, Suman; Hunt, C Anthony

    2004-01-01

    Since there is no widely accepted global theory of biology, tissue engineering and bioengineering lack a theoretical understanding of the systems being engineered. By default, tissue engineering operates with a "reductionist" theoretical approach, inherited from traditional engineering of non-living materials. Long term, that approach is inadequate, since it ignores essential aspects of biology. Metabolism-repair systems are a theoretical framework which explicitly represents two "functional" aspects of living organisms: self-repair and self-replication. Since repair and replication are central to tissue engineering, we advance metabolism-repair systems as a potential theoretical framework for tissue engineering. We present an overview of the framework, and indicate directions to pursue for extending it to the context of tissue engineering. We focus on biological networks, both metabolic and cellular, as one such direction. The construction of these networks, in turn, depends on biological protocols. Together these concepts may help point the way to a global theory of biology appropriate for tissue engineering.

  15. [Research progress of co-culture system for constructing vascularized tissue engineered bone].

    Science.gov (United States)

    Fu, Weili; Xiang, Zhou

    2014-02-01

    To review the research progress of the co-culture system for constructing vascularized tissue engineered bone. The recent literature concerning the co-culture system for constructing vascularized tissue engineered bone was reviewed, including the selection of osteogenic and endothelial lineages, the design and surface modification of scaffolds, the models and dimensions of the co-culture system, the mechanism, the culture conditions, and their application progress. The construction of vascularized tissue engineered bone is the prerequisite for their survival and further clinical application in vivo. Mesenchymal stem cells (owning the excellent osteogenic potential) and endothelial progenitor cells (capable of directional differentiation into endothelial cell) are considered as attractive cell types for the co-culture system to construct vascularized tissue engineered bone. The culture conditions need to be further optimized. Furthermore, how to achieve the clinical goals of minimal invasion and autologous transplantation also need to be further studied. The strategy of the co-culture system for constructing vascularized tissue engineered bone would have a very broad prospects for clinical application in future.

  16. Hydrogel-laden paper scaffold system for origami-based tissue engineering.

    Science.gov (United States)

    Kim, Su-Hwan; Lee, Hak Rae; Yu, Seung Jung; Han, Min-Eui; Lee, Doh Young; Kim, Soo Yeon; Ahn, Hee-Jin; Han, Mi-Jung; Lee, Tae-Ik; Kim, Taek-Soo; Kwon, Seong Keun; Im, Sung Gap; Hwang, Nathaniel S

    2015-12-15

    In this study, we present a method for assembling biofunctionalized paper into a multiform structured scaffold system for reliable tissue regeneration using an origami-based approach. The surface of a paper was conformally modified with a poly(styrene-co-maleic anhydride) layer via initiated chemical vapor deposition followed by the immobilization of poly-l-lysine (PLL) and deposition of Ca(2+). This procedure ensures the formation of alginate hydrogel on the paper due to Ca(2+) diffusion. Furthermore, strong adhesion of the alginate hydrogel on the paper onto the paper substrate was achieved due to an electrostatic interaction between the alginate and PLL. The developed scaffold system was versatile and allowed area-selective cell seeding. Also, the hydrogel-laden paper could be folded freely into 3D tissue-like structures using a simple origami-based method. The cylindrically constructed paper scaffold system with chondrocytes was applied into a three-ring defect trachea in rabbits. The transplanted engineered tissues replaced the native trachea without stenosis after 4 wks. As for the custom-built scaffold system, the hydrogel-laden paper system will provide a robust and facile method for the formation of tissues mimicking native tissue constructs.

  17. Tissue simulant response at projectile impact on flexible fabric armour systems

    NARCIS (Netherlands)

    Bree, J.L.M.J. van; Volker, A.; Heiden, N. van der

    2006-01-01

    Behind Armour Blunt Trauma is a phenomenon which has been studied extensively for rigid personal protective armour systems. These systems used in e.g. bullet proof vests manage to defeat high velocity small arms projectiles. Tissue simulants are used to study behind armour effects. At high velocity

  18. Concepts, The Journal of Defense Systems Acquisition Management. Spring 1982, Volume 5, Number 2. Two Perspectives on Multiyear Procurement European Overview Part II Competition: Does It Lower Costs?

    Science.gov (United States)

    1982-01-01

    The author discusses the need for such an evaluation and provides a methodology for ac- complishing it. ’"a 82 _Automatic Test Equipment: The Critical...Research Directorate, now head of the Flight Controls Section at HQ, Naval Air Systems Command, who hit upon the idea of using our publications mailing list...The autonomous work groups are result- oriented groups of workers, often largely independent of external controls or in- fluences for substantial

  19. Monitoring what governments "give for" and "spend on" vaccine procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline.

    Directory of Open Access Journals (Sweden)

    E A S Nelson

    Full Text Available BACKGROUND: The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments - both rich and poor. Vaccine Procurement Assistance (VPA and Vaccine Procurement Baseline (VPB are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA given for the procurement of vaccines and VPB is a previously suggested measure of the share of Gross Domestic Product (GDP that governments spend on their own vaccine procurement. OBJECTIVE: To determine realistic targets for VPA and VPB. METHODS: Organization for Economic Co-Operation and Development (OECD and World Bank data for 2009 were analyzed to determine the proportions of bilateral ODA from the 23 Development Assistance Committee (DAC countries disbursed (as % of GDP in current US$ for infectious disease control. DAC country contributions to the GAVI Alliance for 2009 were assessed as a measure of multilateral donor support for vaccines and immunization programs. FINDINGS: In 2009, total DAC bilateral ODA was 0.16% of global GDP and 0.25% of DAC GDP. As a percentage of GDP, Norway (0.013% and United Kingdom (0.0085% disbursed the greatest proportion of bilateral ODA for infectious disease control, and Norway (0.024% and Canada (0.008% made the greatest contributions to the GAVI Alliance. In 2009 0.02% of DAC GDP was US$7.61 billion and 0.02% of the GDP of the poorest 117 countries was US$2.88 billion. CONCLUSIONS: Adopting 0.02% GDP as minimum targets for both VPA and VPB is based on realistic estimates of what both developed and developing countries should spend, and can afford to spend, to jointly ensure procurement of vaccines recommended by national and global bodies. New OECD purpose codes are needed to specifically track ODA disbursed for a vaccine procurement; and b immunization programs.

  20. Monitoring what governments "give for" and "spend on" vaccine procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline.

    Science.gov (United States)

    Nelson, E A S; Bloom, David E; Mahoney, Richard T

    2014-01-01

    The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments - both rich and poor. Vaccine Procurement Assistance (VPA) and Vaccine Procurement Baseline (VPB) are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA) given for the procurement of vaccines and VPB is a previously suggested measure of the share of Gross Domestic Product (GDP) that governments spend on their own vaccine procurement. To determine realistic targets for VPA and VPB. Organization for Economic Co-Operation and Development (OECD) and World Bank data for 2009 were analyzed to determine the proportions of bilateral ODA from the 23 Development Assistance Committee (DAC) countries disbursed (as % of GDP in current US$) for infectious disease control. DAC country contributions to the GAVI Alliance for 2009 were assessed as a measure of multilateral donor support for vaccines and immunization programs. In 2009, total DAC bilateral ODA was 0.16% of global GDP and 0.25% of DAC GDP. As a percentage of GDP, Norway (0.013%) and United Kingdom (0.0085%) disbursed the greatest proportion of bilateral ODA for infectious disease control, and Norway (0.024%) and Canada (0.008%) made the greatest contributions to the GAVI Alliance. In 2009 0.02% of DAC GDP was US$7.61 billion and 0.02% of the GDP of the poorest 117 countries was US$2.88 billion. Adopting 0.02% GDP as minimum targets for both VPA and VPB is based on realistic estimates of what both developed and developing countries should spend, and can afford to spend, to jointly ensure procurement of vaccines recommended by national and global bodies. New OECD purpose codes are needed to specifically track ODA disbursed for a) vaccine procurement; and b) immunization programs.

  1. New perspectives in cell delivery systems for tissue regeneration: natural-derived injectable hydrogels.

    Science.gov (United States)

    Munarin, Fabiola; Petrini, Paola; Bozzini, Sabrina; Tanzi, Maria Cristina

    2012-09-27

    Natural polymers, because of their biocompatibility, availability, and physico-chemical properties have been the materials of choice for the fabrication of injectable hydrogels for regenerative medicine. In particular, they are appealing materials for delivery systems and provide sustained and controlled release of drugs, proteins, gene, cells, and other active biomolecules immobilized.In this work, the use of hydrogels obtained from natural source polymers as cell delivery systems is discussed. These materials were investigated for the repair of cartilage, bone, adipose tissue, intervertebral disc, neural, and cardiac tissue. Papers from the last ten years were considered, with a particular focus on the advances of the last five years. A critical discussion is centered on new perspectives and challenges in the regeneration of specific tissues, with the aim of highlighting the limits of current systems and possible future advancements.

  2. Osteoimmunology: the study of the relationship between the immune system and bone tissue.

    Science.gov (United States)

    Arboleya, Luis; Castañeda, Santos

    2013-01-01

    Bone tissue is a highly regulated structure, which plays an essential role in various physiological functions. Through autocrine and paracrine mechanisms, bone tissue is involved in hematopoiesis, influencing the fate of hematopoietic stem cells. There are a number of molecules shared by bone cells and immune system cells indicating that there are multiple connections between the immune system and bone tissue. In order to pool all the knowledge concerning both systems, a new discipline known under the term «osteoimmunology» has been developed. Their progress in recent years has been exponential and allowed us to connect and increase our knowledge in areas not seemingly related such as rheumatoid erosion, postmenopausal osteoporosis, bone metastases or periodontal disease. In this review, we have tried to summarize the most important advances that have occurred in the last decade, especially in those areas of interest related to rheumatology. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  3. Electromagnetic effects on the biological tissue surrounding a transcutaneous transformer for an artificial anal sphincter system*

    Science.gov (United States)

    Zan, Peng; Yang, Bang-hua; Shao, Yong; Yan, Guo-zheng; Liu, Hua

    2010-01-01

    This paper reports on the electromagnetic effects on the biological tissue surrounding a transcutaneous transformer for an artificial anal sphincter. The coupling coils and human tissues, including the skin, fat, muscle, liver, and blood, were considered. Specific absorption rate (SAR) and current density were analyzed by a finite-length solenoid model. First, SAR and current density as a function of frequency (10–107 Hz) for an emission current of 1.5 A were calculated under different tissue thickness. Then relations between SAR, current density, and five types of tissues under each frequency were deduced. As a result, both the SAR and current density were below the basic restrictions of the International Commission on Non-Ionizing Radiation Protection (ICNIRP). The results show that the analysis of these data is very important for developing the artificial anal sphincter system. PMID:21121071

  4. Diagnostics of Procurement Activity of Industrial Enterprise

    OpenAIRE

    Veretennikova Anna B.

    2012-01-01

    The importance of procurement activity of industrial enterprise is substantiated in the article. The results of the critical analysis of the existing approaches to procurement effectiveness evaluating are presented. The main directions of diagnostics of procurement activity of industrial enterprise such as the quality of the organization and the resources, the effectiveness and efficiency, security of logistics operations.В статье обоснована актуальность диагностирования закупочной деятельнос...

  5. Optimal repairable spare-parts procurement policy under total business volume discount environment

    International Nuclear Information System (INIS)

    Pascual, Rodrigo; Santelices, Gabriel; Lüer-Villagra, Armin; Vera, Jorge; Cawley, Alejandro Mac

    2017-01-01

    In asset intensive fields, where components are expensive and high system availability is required, spare parts procurement is often a critical issue. To gain competitiveness and market share is common for vendors to offer Total Business Volume Discounts (TBVD). Accordingly, companies must define the procurement and stocking policy of their spare parts in order to reduce procurement costs and increase asset availability. In response to those needs, this work presents an optimization model that maximizes the availability of the equipment under a TBVD environment, subject to a budget constraint. The model uses a single-echelon structure where parts can be repaired. It determines the optimal number of repairable spare parts to be stocked, giving emphasis on asset availability, procurement costs and service levels as the main decision criteria. A heuristic procedure that achieves high quality solutions in a fast and time-consistent way was implemented to improve the time required to obtain the model solution. Results show that using an optimal procurement policy of spare parts and accounting for TBVD produces better overall results and yields a better availability performance. - Highlights: • We propose a model for procurement of repairable components in single-echelon and business volume discount environments. • We used a mathematical model to develop a competitive heuristic that provides high quality solutions in very short times. • Our model places emphasis on using system availability, procurement costs and service levels as leading decision criteria. • The model can be used as an engine for a multi-criteria Decision Support System.

  6. Organ procurement after euthanasia: Belgian experience.

    Science.gov (United States)

    Ysebaert, D; Van Beeumen, G; De Greef, K; Squifflet, J P; Detry, O; De Roover, A; Delbouille, M-H; Van Donink, W; Roeyen, G; Chapelle, T; Bosmans, J-L; Van Raemdonck, D; Faymonville, M E; Laureys, S; Lamy, M; Cras, P

    2009-03-01

    Euthanasia was legalized in Belgium in 2002 for adults under strict conditions. The patient must be in a medically futile condition and of constant and unbearable physical or mental suffering that cannot be alleviated, resulting from a serious and incurable disorder caused by illness or accident. Between 2005 and 2007, 4 patients (3 in Antwerp and 1 in Liège) expressed their will for organ donation after their request for euthanasia was granted. Patients were aged 43 to 50 years and had a debilitating neurologic disease, either after severe cerebrovascular accident or primary progressive multiple sclerosis. Ethical boards requested complete written scenario with informed consent of donor and relatives, clear separation between euthanasia and organ procurement procedure, and all procedures to be performed by senior staff members and nursing staff on a voluntary basis. The euthanasia procedure was performed by three independent physicians in the operating room. After clinical diagnosis of cardiac death, organ procurement was performed by femoral vessel cannulation or quick laparotomy. In 2 patients, the liver, both kidneys, and pancreatic islets (one case) were procured and transplanted; in the other 2 patients, there was additional lung procurement and transplantation. Transplant centers were informed of the nature of the case and the elements of organ procurement. There was primary function of all organs. The involved physicians and transplant teams had the well-discussed opinion that this strong request for organ donation after euthanasia could not be waived. A clear separation between the euthanasia request, the euthanasia procedure, and the organ procurement procedure is necessary.

  7. Reconsidering Planning and Management of Medical Devices Procurement in Public Health Services in Cyprus.

    Science.gov (United States)

    Theodorou, Mamas; Georgiou, Marina; Nikolentzos, Athanasios; Bellali, Thalia

    2015-04-19

    Hospital procurement is a crucial field for any health care system, not only for economic reasons but also for reasons related to the quality and safety of the services provided. That is why the process of procurement is, in most countries, governed by a strict legal framework and policy mechanisms. This study investigates the problems and inefficiencies associated with the procurement of medical devices in public hospitals in Cyprus and formulates empirically documented proposals for improvement. Using the Delphi method, a group of 38 experts approach the procurement system in Cyprus from different angles, achieving high rates of consensus on 35 different statements on the weaknesses and problems of the current medical device procurement system, as well as presenting proposals and recommendations for improvement. The findings are highly valuable for future policy initiatives in Cyprus in the light of the economic crisis and the expected implementation of the new General Health Insurance System (GeSY), which the Government of the Republic of Cyprus and the Troika has agreed.

  8. Strain-time cell death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury

    NARCIS (Netherlands)

    Gefen, A.; Nierop, van B.J.; Bader, D.L.; Oomens, C.W.J.

    2008-01-01

    Deep tissue injury (DTI) is a severe pressure ulcer that results from sustained deformation of muscle tissue overlying bony prominences. In order to understand the etiology of DTI, it is essential to determine the tolerance of muscle cells to large mechanical strains. In this study, a new

  9. Innovative Procurement and Partnerships in Facilities Management

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2010-01-01

    strong requirements on the management style and company culture. Limitations of the research: The research is only based on two case studies, which obviously limits the possibility to generalize the results. Practical applications: The research presents two specific examples of innovative procurement......Aim: The aim of the paper is to present, analyse and identify learning from two case studies of innovative procurement in Facilities Management (FM) concerning the establishments of partnerships between clients and providers. Approach and methodology: A major study of FM best practice covering 36...

  10. Greening Non-Product-Related Procurement

    DEFF Research Database (Denmark)

    Mosgaard, Mette; Riisgaard, Henrik; Huulgaard, Rikke Dorothea

    2013-01-01

    link to the strategy for greening private consumption, as similarities exist and the purchasers lean on their private experiences when purchasing non-product related items; and finally, 3) Intensify the efforts in product categories in which strict normative legislation makes management more motivated....... environmental benefits of millions of procurement decisions do add up to large environmental improvement potentials. Thus, non-product-related procurement focuses on the similarities in the purchases made across different sectors. Explorative interviews with purchasers in Danish companies form the basis...

  11. Organizational determinants in the procurement and transplantation pathway: a review

    Directory of Open Access Journals (Sweden)

    Triassi M

    2014-12-01

    were selected as potentially relevant. Results: We found three prevalent areas of interest focused on organizational elements: global organizational strategies scenario, clinical hospital organization, and citizenship and social scenario. Conclusion: We reached the conclusion that organization has a central role in different scenarios of procurement and transplantation in a continuum from government to hospital (the core of the system and finally among citizens. A standardized hospital pathway definitely remains the essential step in order to ameliorate either procurement or transplantation. Keywords: transplant procurement, management, organizational tool, network

  12. Temperature profiles of different cooling methods in porcine pancreas procurement.

    Science.gov (United States)

    Weegman, Bradley P; Suszynski, Thomas M; Scott, William E; Ferrer Fábrega, Joana; Avgoustiniatos, Efstathios S; Anazawa, Takayuki; O'Brien, Timothy D; Rizzari, Michael D; Karatzas, Theodore; Jie, Tun; Sutherland, David E R; Hering, Bernhard J; Papas, Klearchos K

    2014-01-01

    Porcine islet xenotransplantation is a promising alternative to human islet allotransplantation. Porcine pancreas cooling needs to be optimized to reduce the warm ischemia time (WIT) following donation after cardiac death, which is associated with poorer islet isolation outcomes. This study examines the effect of four different cooling Methods on core porcine pancreas temperature (n = 24) and histopathology (n = 16). All Methods involved surface cooling with crushed ice and chilled irrigation. Method A, which is the standard for porcine pancreas procurement, used only surface cooling. Method B involved an intravascular flush with cold solution through the pancreas arterial system. Method C involved an intraductal infusion with cold solution through the major pancreatic duct, and Method D combined all three cooling Methods. Surface cooling alone (Method A) gradually decreased core pancreas temperature to <10 °C after 30 min. Using an intravascular flush (Method B) improved cooling during the entire duration of procurement, but incorporating an intraductal infusion (Method C) rapidly reduced core temperature 15-20 °C within the first 2 min of cooling. Combining all methods (Method D) was the most effective at rapidly reducing temperature and providing sustained cooling throughout the duration of procurement, although the recorded WIT was not different between Methods (P = 0.36). Histological scores were different between the cooling Methods (P = 0.02) and the worst with Method A. There were differences in histological scores between Methods A and C (P = 0.02) and Methods A and D (P = 0.02), but not between Methods C and D (P = 0.95), which may highlight the importance of early cooling using an intraductal infusion. In conclusion, surface cooling alone cannot rapidly cool large (porcine or human) pancreata. Additional cooling with an intravascular flush and intraductal infusion results in improved core porcine pancreas temperature profiles during procurement and

  13. Late effects of normal tissues (lent) scoring system: the soma scale

    International Nuclear Information System (INIS)

    Mornex, F.; Pavy, J.J.; Denekamp, J.

    1997-01-01

    Radiation tolerance of normal tissues remains the limiting factor for delivering tumoricidal dose. The late toxicity of normal tissues is the most critical element of an irradiation: somatic, functional and structural alterations occur during the actual treatment itself, but late effects manifest months to years after acute effects heal, and may progress with time. The optimal therapeutic ratio ultimately requires not only complete tumor clearance, but also minimal residual injury to surrounding vital normal tissues. The disparity between the intensity of acute and late effects and the inability to predict the eventual manifestation of late normal tissue injury has made radiation oncologists recognize the importance of careful patient follow-up. There is so far no uniform toxicity scoring system to compare several clinical studies in the absence of a 'common toxicity language'. This justifies the need to establish a precise evaluation system for the analysis of late effects of radiation on normal tissues. The SOMA/LENT scoring system results from an international collaboration. European Organization Treatment of Cancer (EORTC) and Radiation Therapy Oncology Group (RTOG) have created subcommittees with the aim of addressing the question of standardized toxic effects criteria. This effort appeared as a necessity to standardize and improve the data recording, to then describe and evaluate uniform toxicity at regular time intervals. The current proposed scale is not yet validated, and should be used cautiously. (authors)

  14. Management of Contracts for F110 Engine Procurements

    National Research Council Canada - National Science Library

    Granetto, Paul

    2001-01-01

    This audit was performed in response to an allegation to the Defense Hotline that the Wright-Patterson Air Force Base Procurement Contracting Office made poor procurement decisions on F110 aircraft engine contracts...

  15. GPP Webinar: Solar Procurement Templates and Tools for Higher Education

    Science.gov (United States)

    Green Power Partnership webinar on solar procurement for Higher Education which features various tools and templates that schools can use to shape and manage the solar procurement process to a successful outcome.

  16. Design of reactive power procurement in deregulated electricity market

    African Journals Online (AJOL)

    user

    novel reactive power procurement model is proposed, which ensure secure and ..... The simulation is performed in the Matlab. .... focus of this paper is a reactive procurement market model, which is a basically two-step optimization process.

  17. 76 FR 37069 - Procurement List; Proposed Additions and Deletion

    Science.gov (United States)

    2011-06-24

    ... Certification The following products and service are proposed for addition to Procurement List for production by... following product is proposed for deletion from the Procurement List: Product Detergent, Laundry NSN: 7930...

  18. Elastin Cables Define the Axial Connective Tissue System in the Murine Lung.

    Science.gov (United States)

    Wagner, Willi; Bennett, Robert D; Ackermann, Maximilian; Ysasi, Alexandra B; Belle, Janeil; Valenzuela, Cristian D; Pabst, Andreas; Tsuda, Akira; Konerding, Moritz A; Mentzer, Steven J

    2015-11-01

    The axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in lung volume. Although the molecular anatomy of the axial system remains undefined, the fiber continuum of the lung is central to contemporary models of lung micromechanics and alveolar regeneration. To provide a detailed molecular structure of the axial connective tissue system, we examined the extracellular matrix of murine lungs. The lungs were decellularized using a 24 hr detergent treatment protocol. Systematic evaluation of the decellularized lungs demonstrated no residual cellular debris; morphometry demonstrated a mean 39 ± 7% reduction in lung dimensions. Scanning electron microscopy (SEM) demonstrated an intact structural hierarchy within the decellularized lung. Light, fluorescence, and SEM of precision-cut lung slices demonstrated that alveolar duct structure was defined by a cable line element encased in basement membrane. The cable line element arose in the distal airways, passed through septal tips and inserted into neighboring blood vessels and visceral pleura. The ropelike appearance, collagenase resistance and anti-elastin immunostaining indicated that the cable was an elastin macromolecule. Our results indicate that the helical line element of the axial connective tissue system is composed of an elastin cable that not only defines the structure of the alveolar duct, but also integrates the axial connective tissue system into visceral pleura and peripheral blood vessels. © 2015 Wiley Periodicals, Inc.

  19. Restoring nervous system structure and function using tissue engineered living scaffolds

    Institute of Scientific and Technical Information of China (English)

    Laura A Struzyna; James P Harris; Kritika S Katiyar; H Isaac Chen; D KacyCullen

    2015-01-01

    Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner-vous system injury or neurodegenerative disease. Disconnection of axon pathways – the long-distance ifbers connecting specialized regions of the central nervous system or relaying peripheral signals – is a common feature of many neurological disorders and injury. However, functional axonal regenera-tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi-neered “living scaffolds”, which are preformed three-dimensional constructs consisting of living neural cells in a deifned, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration – mimicking key developmental mechanisms– or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in preclinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

  20. Restoring nervous system structure and function using tissue engineered living scaffolds

    Directory of Open Access Journals (Sweden)

    Laura A Struzyna

    2015-01-01

    Full Text Available Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following nervous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regeneration rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engineered "living scaffolds", which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in preclinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

  1. An approach to improve management visibility within the procurement and financial group at Goldstone

    Science.gov (United States)

    Maiocco, F. R.; Rozek, J. B.

    1976-01-01

    Improvements in the operational efficiency of the data management systems at the Goldstone Deep Space Communications Complex (GDSCC) are discussed. This addresses the existing procurement and financial management data system at GDSCC, identifies management requirements for better visibility, describes a proposed computerized data management system, summarizes results to data, and identifies plans for future development.

  2. A system for the obtention and analysis of diffuse reflection spectra from biological tissue

    International Nuclear Information System (INIS)

    La Cadena, A. de; La Rosa, J. de; Stolik, S.

    2012-01-01

    The diffuse reflection spectroscopy is a technique with is possible to study biological tissue. In the field of the biomedical applications is useful for diagnostic purposes, since is possible to analyze biological tissue in a non invasive way. also, can be used with therapeutical purposes, for example in photodynamic therapy or laser surgery because with this technique it can be determined the biological effects produced by these treatments. In this paper is shown the development of a system to obtain and analyze diffuse reflection spectra of biological tissues, using a LED as a light source, that emits light between 400-700nm. The system has an interface for the regulation of the emittance of the LED. For diffuse reflectance spectra analysis, we use an HR4000CG-UV-NIR spectrometer. (Author)

  3. Multi-Stream Saline-Jet Dissection Using a Simple Irrigation System Defines Difficult Tissue Planes

    Science.gov (United States)

    Ng, Philip CH

    2010-01-01

    Introduction: Single-stream hydro-jet dissection is increasingly used in various laparoscopic procedures, but its use requires special equipment. We describe a simple method for using an irrigation system for saline-jet tissue dissection as a useful adjunct prior to adhesiolysis. Material and Methods: Intraabdominal adhesions prolong laparoscopic procedures, because tissue planes are difficult to identify. We performed multi-jet saline dissection (MSSJ) between 2000 and 2009 in more than 500 patients during laparoscopy involving hernias, gallbladders, appendices, and intestinal obstructions. We use a standard suction irrigation probe, which is attached to a 1-liter saline bag with an inflatable cuff around to create a pressure of 250mm Hg to 300mm Hg. In effect, this is the standard setup generally used for irrigation. After using saline dissection, tissue planes can be better defined and the structures can then be separated. Result and Discussion: Using this method, we have successfully identified tissue planes in spite of dense adhesions, and our conversion rates to open have been reduced dramatically. This method is relatively safer than other modalities of tissue dissection, such as diathermy, ultrasonic, blunt or sharp dissection. The disadvantage is that with tissues saturated with saline it becomes more difficult to use diathermy hemostasis. Care has to be exercised in monitoring the temperature and volume of the fluid used. PMID:20529528

  4. Legal Guarantees of Economic Competition in the European Union Public Procurement Regulation

    Directory of Open Access Journals (Sweden)

    E. Kosiński

    2017-01-01

    Full Text Available Purpose: the purpose of this publication is to assess legal guaranties of competition (free competition between contractors in broadly perceived process of granting public procurement, which means not only entering into a contract subject to the specific legal regime, concluded by a public purchaser, or possible private purchaser subordinated to that legal regime, with a contractor (contractors in order to satisfy its demand for certain goods or services, but also a due course of the whole process of granting public procurement, perceived as a sequence of factual and legal actions beginning with the moment of public announcement of a procurement, sending an invitation for submitting offers or sending invitation to negotiate for selection of an offer of a given contractor, up till final fulfilment of all obligations of the parties under the public procurement contract. Methods: the major research method is the dogmatic-legal method, namely an analysis of legal text of different laws. Moreover, there is a critical analysis of scholar literature. The most important in this context is to indicate mutual co-relations between competition and fair competition in area of public procurement system and to point other major principles of the public procurement process, such as non-discrimination rule, transparency, impartiality and objectiveness rule, legality rule, openness, rule of written form, primate of using tender mode (competitive mode, in another words it is a rule of extraordinary application of non-competitive modes or primate of granting public procurement in a tender mode. All of those rules constitute together components of the guarantee of genuine competition within the whole process of granting a public procurement. It must be stressed that the literature in the area of research in not really rich. This is accurate in terms of Polish literature and EU literature, too. Results. Conclusions and relevance: results of the research are such

  5. An integrated approach for optimal frequency regulation service procurement in India

    International Nuclear Information System (INIS)

    Parida, S.K.; Singh, S.N.; Srivastava, S.C.

    2009-01-01

    Ancillary services (AS) management has become an important issue to be addressed in the Indian power system after adaption of the restructuring and unbundling processes following the enactment of Indian Electricity Act 2003. In an electricity market, frequency regulation is one of the ancillary services, which must be procured by the system operator (SO) from the market participants by some regulatory mechanism or using market-based approaches. It is important for the SO to optimally procure this service from the AS market. In this paper, an approach for determining the optimal frequency regulation service procurement has been proposed for equitable payment to generators and recovery from the customers. The effectiveness of the proposed method has been demonstrated on a practical Northern Regional Electricity Board (NREB) system of India. (author)

  6. Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

    Directory of Open Access Journals (Sweden)

    Yang Rongze

    2011-10-01

    Full Text Available Abstract Background Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type 1 receptor (CB1 and fatty acid amide hydrolase (FAAH are different in subcutaneous abdominal and gluteal adipose tissue, and whether hypocaloric diet and aerobic exercise influence subcutaneous adipose tissue CB1 and FAAH gene expression in obese women. Methods Thirty overweight or obese, middle-aged women (BMI = 34.3 ± 0.8 kg/m2, age = 59 ± 1 years underwent one of three 20-week weight loss interventions: caloric restriction only (CR, N = 9, caloric restriction plus moderate-intensity aerobic exercise (CRM, 45-50% HRR, N = 13, or caloric restriction plus vigorous-intensity aerobic exercise (CRV, 70-75% HRR, N = 8. Subcutaneous abdominal and gluteal adipose tissue samples were collected before and after the interventions to measure CB1 and FAAH gene expression. Results At baseline, FAAH gene expression was higher in abdominal, compared to gluteal adipose tissue (2.08 ± 0.11 vs. 1.78 ± 0.10, expressed as target gene/β-actin mRNA ratio × 10-3, P Conclusions There are depot differences in subcutaneous adipose tissue endocannabinoid system gene expression in obese individuals. Aerobic exercise training may preferentially modulate abdominal adipose tissue endocannabinoid-related gene expression during dietary weight loss. Trial Registration ClinicalTrials.gov: NCT00664729.

  7. Bioactive Molecule-loaded Drug Delivery Systems to Optimize Bone Tissue Repair.

    Science.gov (United States)

    Oshiro, Joao Augusto; Sato, Mariana Rillo; Scardueli, Cassio Rocha; Lopes de Oliveira, Guilherme Jose Pimentel; Abucafy, Marina Paiva; Chorilli, Marlus

    2017-01-01

    Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. Thus, the development of bioactive molecule-loaded drug delivery systems (DDS) to repair bone tissue has been the subject of intense research. DDS can optimize the repair of bone tissue owing to their physicochemical properties, which improve cellular interactions and enable the incorporation and prolonged release of bioactive molecules. These characteristics are fundamental to favor bone tissue homeostasis, since the biological activity of these factors depends on how accessible they are to the cell. Considering the importance of these DDS, this review aims to present relevant information on DDS when loaded with osteogenic growth peptide and bone morphogenetic protein. These are bioactive molecules that are capable of modulating the differentiation and proliferation of mesenchymal cells in bone tissue cells. Moreover, we will present different approaches using these peptide and protein-loaded DDS, such as synthetic membranes and scaffolds for bone regeneration, synthetic grafts, bone cements, liposomes, and micelles, which aim at improving the therapeutic effectiveness, and we will compare their advantages with commercial systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  8. Optical Characterization of Tissue Phantoms Using a Silicon Integrated fdNIRS System on Chip.

    Science.gov (United States)

    Sthalekar, Chirag C; Miao, Yun; Koomson, Valencia Joyner

    2017-04-01

    An interface circuit with signal processing and digitizing circuits for a high frequency, large area avalanche photodiode (APD) has been integrated in a 130 nm BiCMOS chip. The system enables the absolute oximetry of tissue using frequency domain Near Infrared Spectroscopy (fdNIRS). The system measures the light absorbed and scattered by the tissue by measuring the reduction in the amplitude of signal and phase shift introduced between the light source and detector which are placed a finite distance away from each other. The received 80 MHz RF signal is downconverted to a low frequency and amplified using a heterodyning scheme. The front-end transimpedance amplifier has a 3-level programmable gain that increases the dynamic range to 60 dB. The phase difference between an identical reference channel and the optical channel is measured with a 0.5° accuracy. The detectable current range is [Formula: see text] and with a 40 A/W reponsivity using the APD, power levels as low as 500 pW can be detected. Measurements of the absorption and reduced scattering coefficients of solid tissue phantoms using this system are compared with those using a commercial instrument with differences within 30%. Measurement of a milk based liquid tissue phantom show an increase in absorption coefficient with addition of black ink. The miniaturized circuit serves as an efficiently scalable system for multi-site detection for applications in neonatal cerebral oximetry and optical mammography.

  9. NBAS mutations cause a multisystem disorder involving bone, connective tissue, liver, immune system, and retina

    NARCIS (Netherlands)

    Segarra, Nuria Garcia; Ballhausen, Diana; Crawford, Heather; Perreau, Matthieu; Campos-Xavier, Belinda; van Spaendonck-Zwarts, Karin; Vermeer, Cees; Russo, Michel; Zambelli, Pierre-Yves; Stevenson, Brian; Royer-Bertrand, Beryl; Rivolta, Carlo; Candotti, Fabio; Unger, Sheila; Munier, Francis L.; Superti-Furga, Andrea; Bonafé, Luisa

    2015-01-01

    We report two unrelated patients with a multisystem disease involving liver, eye, immune system, connective tissue, and bone, caused by biallelic mutations in the neuroblastoma amplified sequence (NBAS) gene. Both presented as infants with recurrent episodes triggered by fever with vomiting,

  10. Effects of tissue impedance on heat generation during RF delivery with the Thermage system

    Science.gov (United States)

    Tomkoria, Sara; Pope, Karl

    2005-04-01

    The Thermage ThermaCool TC system is a non-ablative RF device designed to promote tissue tightening and contouring. The system delivers RF energy to a target area under the skin, with volumetric tissue heating in that area. While the amount of energy delivered to a patient can be controlled by ThermaCool system settings, the distribution of energy to the treatment area and underlying layers is variable from individual to individual due to differences in body composition. The present study investigated how local tissue impedance affects the amount of discomfort experienced by patients during RF energy delivery. Discomfort results from heat generation in the treatment area. By using features of the ThermaCool TC System, local impedance (impedance of the treatment area), bulk impedance (impedance of the underlying tissue layers), and total impedance (the sum of local and bulk impedance) were measured for 35 patients. For each patient, impedance measurements were compared to discomfort levels expressed during treatment. Analysis of whole body, local, and bulk impedance values indicate that the percent of total body impedance in the local treatment area contributes to discomfort levels expressed by patients during treatment.

  11. Effects of Procurement Related Factors on Construction Project ...

    African Journals Online (AJOL)

    Several Literatures in construction management support the view that procurements have impacts on project performance. Aim of this study is to investigate the effects of procurement related factors of procurement selection criteria, tendering methods and variation orders on project performance. Purpose of the study is to ...

  12. 7 CFR 235.9 - Procurement and property management standards.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement and property management standards. 235.9... Procurement and property management standards. (a) Requirements. State agencies shall comply with the requirements of 7 CFR part 3016 concerning the procurement of supplies, equipment and other services with State...

  13. 7 CFR 248.21 - Procurement and property management.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Procurement and property management. 248.21 Section... Provisions § 248.21 Procurement and property management. (a) Requirements. State agencies shall comply with the requirements of 7 CFR part 3016 for procurement of supplies, equipment and other services with...

  14. 76 FR 78248 - Procurement List; Addition and Deletions

    Science.gov (United States)

    2011-12-16

    .... Service Type/Location: Laundry Service, Stratton Medical Center, 113 Holland Ave, Albany, NY. [[Page 78249...: Addition to and Deletions from the Procurement List. SUMMARY: This action adds a service to the Procurement... disabilities, and deletes products and services from the Procurement List previously furnished by such agencies...

  15. Greening Operations Management: An Online Sustainable Procurement Course for Practitioners

    Science.gov (United States)

    Walker, Helen L.; Gough, Stephen; Bakker, Elmer F.; Knight, Louise A.; McBain, Darian

    2009-01-01

    In the Operations Management field, sustainable procurement has emerged as a way to green the purchasing and supply process. This paper explores issues in sustainable procurement training. The authors formed an interdisciplinary team to design, deliver and evaluate a training programme to promote and develop sustainable procurement in the United…

  16. Nepal : Electronic Government Procurement Readiness Assessment and Roadmap

    OpenAIRE

    World Bank

    2007-01-01

    The assessment focused on the degree of readiness of Government of Nepal's (GoN's) current public procurement environment for making a transition from a traditional paper-based, manual procurement transaction processing and communication to electronic government procurement (e-GP). Some 20 public and private sector organizations, involved in a wide range of functions that relate to public...

  17. Maldives : Electronic Government Procurement Readiness Assessment and Roadmap

    OpenAIRE

    World Bank

    2007-01-01

    The assessment focuses on the degree of readiness of Government of The Maldives's (GoTM's) current public procurement environment for making a transition from traditional paper-based, manual methods of procurement transaction processing and communication to electronic government procurement (e-GP). The e-GP Assessment was discussed individually with informed respondents in the public and p...

  18. Study on Comparative Efficiencies in Vaccine Procurement Mechanisms

    OpenAIRE

    Bumpas, Janet

    2008-01-01

    Vaccinations are amongst the most cost-effective public health interventions. Vaccine procurement is a complex issue that interweaves the domains of public health, commodity security, ethics, and procurement. Its cross-disciplinary nature means that neither a straightforward analysis stemming from just one discipline nor a cookie-cutter application of World Bank procurement principles of e...

  19. 32 CFR 22.205 - Distinguishing assistance from procurement.

    Science.gov (United States)

    2010-07-01

    ... procurement contract, is the appropriate instrument, based on the following: (a) Purpose. (1) The grants... purpose is acquisition, then the grants officer shall judge that a procurement contract is the appropriate... 32 National Defense 1 2010-07-01 2010-07-01 false Distinguishing assistance from procurement. 22...

  20. Procurement maturity, alignment and performance: a Dutch hospital case comparison.

    NARCIS (Netherlands)

    Plomp, M.; Batenburg, R.

    2009-01-01

    Procurement is an important supporting business function, with which competitive advantage can potentially be achieved. In this paper, the relation between maturity and alignment in procurement on the one hand, and procurement performance on the other, is investigated in the case study setting of

  1. Procurement Maturity, Alignment and Performance: a Dutch Hospital Case Comparison

    NARCIS (Netherlands)

    Plomp, M.G.A.; Batenburg, R.S.

    2009-01-01

    Procurement is an important supporting business function, with which competitive advantage can potentially be achieved. In this paper, the relation between maturity and alignment in procurement on the one hand, and procurement performance on the other, is investigated in the case study setting of

  2. 41 CFR 101-26.602-4 - Procurement of coal.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement of coal. 101... PROGRAM 26.6-Procurement Sources Other Than GSA § 101-26.602-4 Procurement of coal. (a) Federal agencies desiring to participate in the Defense Fuel Supply Center coal contracting program for carload delivery...

  3. 20 CFR 627.420 - Procurement.

    Science.gov (United States)

    2010-04-01

    ... sources, unless it is demonstrated that the JTPA-funded alternative services or facilities would be more...) Each State and subrecipient shall conduct procurements in a manner which provides full and open... pricing practices between firms or organizations or between affiliated companies or organizations; (iv...

  4. 38 CFR 49.46 - Procurement records.

    Science.gov (United States)

    2010-07-01

    ..., HOSPITALS, AND OTHER NON-PROFIT ORGANIZATIONS Post-Award Requirements Procurement Standards § 49.46... of competition when competitive bids or offers are not obtained, and (c) Basis for award cost or price. (Authority: Pub. L. 104-156; 110 Stat. 1396) ...

  5. 45 CFR 2541.360 - Procurement.

    Science.gov (United States)

    2010-10-01

    ... foster greater economy and efficiency, grantees and subgrantees are encouraged to enter into State and... procured, and when necessary, shall set forth those minimum essential characteristics and standards to... grantee or subgrantee desires to have the review accomplished after a solicitation has been developed, the...

  6. 20 CFR 437.36 - Procurement.

    Science.gov (United States)

    2010-04-01

    ... greater economy and efficiency, grantees and subgrantees are encouraged to enter into State and local... procured, and when necessary, must set forth those minimum essential characteristics and standards to which... desires to have the review accomplished after a solicitation has been developed, SSA may still review the...

  7. Online Reverse Auctions for Procurement of Services

    NARCIS (Netherlands)

    U.L. Radkevitch (Uladzimir)

    2008-01-01

    textabstractOnline reverse auctions, in which a buyer seeks to select a supplier and suppliers compete for contracts by bidding online, revolutionized corporate procurement early this century. Shortly after they had been pioneered by General Electric, many companies rushed to adopt reverse auctions

  8. 21 CFR 1403.36 - Procurement.

    Science.gov (United States)

    2010-04-01

    ... be a selection criteria provided its application leaves an appropriate number of qualified firms... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Procurement. 1403.36 Section 1403.36 Food and.... No employee, officer or agent of the grantee or subgrantee shall participate in selection, or in the...

  9. 78 FR 59658 - Procurement List; Additions

    Science.gov (United States)

    2013-09-27

    ... Accordingly, the following products and services are added to the Procurement List: Products Laundry Net... ADMINISTRATION, BOULDER, CO. Service Type/Location: Laundry Service, US Coast Guard Base, Portsmouth, VA. NPA... GUARD, BASE PORTSMOUTH, PORTSMOUTH, VA Service Type/Location: Laundry Service, Federal Bureau of Prisons...

  10. Pre-commercial procurement : regulatory effectiveness?

    NARCIS (Netherlands)

    Apostol, Anca Ramona

    2014-01-01

    Is public procurement of research and development (‘R&D’) services the key to European Union (‘EU’)’s sustainable welfare? Is it being regulated in accordance with economic prescripts for effectiveness? Is the regulatory and policy setting clear and comprehensive in order to stimulate a widespread

  11. 78 FR 34351 - Procurement List; Additions

    Science.gov (United States)

    2013-06-07

    .... ADDRESSES: Committee for Purchase from People Who are Blind or Severely Disabled, 1401 S. Clark Street... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Additions AGENCY: Committee for Purchase from People Who are Blind or Severely Disabled. ACTION: Additions to the...

  12. 78 FR 53734 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-08-30

    ...: Committee for Purchase From People Who Are Blind or Severely Disabled, 1401 S Clark Street, Suite 10800... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Proposed Additions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed...

  13. 78 FR 77105 - Procurement List; Proposed Addition

    Science.gov (United States)

    2013-12-20

    ... People Who Are Blind or Severely Disabled, 1401 S. Clark Street, Suite 10800, Arlington, Virginia, 22202... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Proposed Addition AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed...

  14. 78 FR 50040 - Procurement List, Proposed Additions

    Science.gov (United States)

    2013-08-16

    ... People Who Are Blind or Severely Disabled, 1401 S Clark Street, Suite 10800, Arlington, Virginia, 22202... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List, Proposed Additions AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed...

  15. 78 FR 19248 - Procurement List; Proposed Addition

    Science.gov (United States)

    2013-03-29

    ... Purchase From People Who Are Blind or Severely Disabled, 1401 S. Clark Street, Suite 10800, Arlington... COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED Procurement List; Proposed Addition AGENCY: Committee for Purchase From People Who Are Blind or Severely Disabled. ACTION: Proposed...

  16. Organ procurement from executed prisoners in China.

    Science.gov (United States)

    Sharif, A; Singh, M Fiatarone; Trey, T; Lavee, J

    2014-10-01

    Organ procurement from executed prisoners in China is internationally condemned, yet this practice continues unabated in 2014. This is despite repeated announcements from Chinese authorities that constructive measures have been undertaken to conform to accepted ethical standards. While there is unanimous agreement on the unethical nature of using organs from executed prisoners, due to its limitations on voluntary and informed consent, there is insufficient coverage of forced organ procurement from prisoners of conscience without consent. Strategies to influence positive change in China over the last few decades have failed to bring this practice to an end. While organ donation and transplantation services in China have undergone considerable structural changes in the last few years, fundamental attempts to shift practice to ethically sourced organs have floundered. In this article, we discuss the organ trade in China, reflect upon organ procurement from executed prisoners (including both capital prisoners and prisoners of conscience) and provide an overview of contradictory Chinese efforts to halt forced organ procurement from executed prisoners. Finally, we highlight current actions being taken to address this issue and offer comprehensive recommendations to bring this ethically indefensible practice to an immediate end. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

  17. Issues in organ procurement, allocation, and transplantation.

    Science.gov (United States)

    Nierste, Deborah

    2013-01-01

    Organ transplantation extends lives and improves health but presents complex ethical dilemmas for nurses caring for donors, recipients, and their families. This article overviews organ procurement and allocation, discusses ethical dilemmas in transplantation, and offers strategies from professional and biblical perspectives for coping with moral distress and maintaining compassionate care.

  18. 77 FR 70738 - Procurement List Additions

    Science.gov (United States)

    2012-11-27

    ... Fire Fighters, Metal NSN: CBFF0053--Nameplate, Navy Fire Fighters, 2 Line, Metal NSN: CBFF0054--Collar, Brass, Navy Fire Fighters, Metal NSN: CBFF0055--Shorts, Navy Fire Fighters, Physical Training, Small... following products are added to the Procurement List: PRODUCTS: NSN: CBFF0001--Shirt, Navy Fire Fighters...

  19. SMEs cooperate to meet social procurement conditions

    NARCIS (Netherlands)

    Oden, Petra

    2015-01-01

    A growing amount of (semi) public organizations in the Netherlands write tenders with mandatory social conditions. It is important for SMEs to focus on social procurement in their business strategy. SMEs should be proactive and try to affect the conditions (semi) public organizations write in their

  20. 76 FR 57719 - Procurement List; Proposed Additions

    Science.gov (United States)

    2011-09-16

    ... proposed for addition to the Procurement List for production by the nonprofit agencies listed: Products NSN: 7930-00-NIB-0583--Refills, Bathroom Cleaner and Deodorizer, Cartridge Concentrate. NSN: 7930-00-NIB-0584--Starter Kit, Bathroom Cleaner and Deodorizer, Cartridge Concentrate. NSN: 7930-00-NIB-0585...

  1. 78 FR 12296 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-02-22

    ... services are proposed for addition to the Procurement List for production by the nonprofit agencies listed... and Trailer Wash, 55 GL NSN: 7930-00-NIB-0649--Cleaner/Degreaser, Heavy Duty, Biodegradable, Car and Trucks, 5 GL NSN: 7930-00-NIB-0650--Cleaner/Degreaser, Heavy Duty, Biodegradable, Car and Trucks, 55 GL...

  2. 36 CFR 1207.36 - Procurement.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Procurement. 1207.36 Section 1207.36 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES... resonableness can be established on the basis of a catalog or market price of a commercial product sold in...

  3. Antiretroviral procurement and supply chain management.

    Science.gov (United States)

    Ripin, David J; Jamieson, David; Meyers, Amy; Warty, Umesh; Dain, Mary; Khamsi, Cyril

    2014-01-01

    Procurement, the country-level process of ordering antiretrovirals (ARVs), and supply chain management, the mechanism by which they are delivered to health-care facilities, are critical processes required to move ARVs from manufacturers to patients. To provide a glimpse into the ARV procurement and supply chain, the following pages provide an overview of the primary stakeholders, principal operating models, and policies and regulations involved in ARV procurement. Also presented are key challenges that need to be addressed to ensure that the supply chain is not a barrier to the goal of universal coverage. This article will cover the steps necessary to order and distribute ARVs, including different models of delivery, key stakeholders involved, strategic considerations that vary depending on context and policies affecting them. The single drug examples given illustrate the complications inherent in fragmented supply and demand-driven models of procurement and supply chain management, and suggest tools for navigating these hurdles that will ultimately result in more secure and reliable ARV provision. Understanding the dynamics of ARV supply chain is important for the global health community, both to ensure full and efficient treatment of persons living with HIV as well as to inform the supply chain decisions for other public health products.

  4. Procurement Officer | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... efficient, and ethical and provide the best possible value to the IDRC; supporting the ... procurement processes are perceived by suppliers as fair, open and ethical; ... while ensuring to protect confidential information;; analyses, negotiates and ... and knowledge, and interpret, assess and communicate current IDRC policy, ...

  5. 78 FR 73504 - Procurement List; Proposed Additions

    Science.gov (United States)

    2013-12-06

    ... Logistics Support Detachment, Undisclosed Location*, Ft. Belvoir, VA. NPA: MVLE, Inc., Springfield, VA. Contracting Activity: Directorate of Contracting Procurement Logistics Support Detachment, Fort Belvoir, VA.... Lineback, Director, Business Operations. [FR Doc. 2013-29139 Filed 12-5-13; 8:45 am] BILLING CODE 6353-01-P ...

  6. 77 FR 60969 - Procurement List; Additions

    Science.gov (United States)

    2012-10-05

    ... Are Blind or Severely Disabled published a notice for additions to the Procurement List with the... Committee for Purchase From People Who Are Blind or Severely Disabled published notices of proposed..., Phoenix, AZ. Service Type/Location: Custodial and Grounds Maintenance Services, Austin Courthouse, 501...

  7. Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization

    Science.gov (United States)

    Alqasemi, Umar; Li, Hai; Yuan, Guangqian; Kumavor, Patrick; Zanganeh, Saeid; Zhu, Quing

    2014-07-01

    Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.

  8. Brief Communication: Tissue-engineered Microenvironment Systems for Modeling Human Vasculature

    Science.gov (United States)

    Tourovskaia, Anna; Fauver, Mark; Kramer, Gregory; Simonson, Sara; Neumann, Thomas

    2015-01-01

    The high attrition rate of drug candidates late in the development process has led to an increasing demand for test assays that predict clinical outcome better than conventional 2D cell culture systems and animal models. Government agencies, the military, and the pharmaceutical industry have started initiatives for the development of novel in-vitro systems that recapitulate functional units of human tissues and organs. There is growing evidence that 3D cell arrangement, co-culture of different cell types, and physico-chemical cues lead to improved predictive power. A key element of all tissue microenvironments is the vasculature. Beyond transporting blood the microvasculature assumes important organ-specific functions. It is also involved in pathologic conditions, such as inflammation, tumor growth, metastasis, and degenerative diseases. To provide a tool for modeling this important feature of human tissue microenvironments, we developed a microfluidic chip for creating tissue-engineered microenvironment systems (TEMS) composed of tubular cell structures. Our chip design encompasses a small chamber that is filled with an extracellular matrix (ECM) surrounding one or more tubular channels. Endothelial cells seeded into the channels adhere to the ECM walls and grow into perfusable tubular tissue structures that are fluidically connected to upstream and downstream fluid channels in the chip. Using these chips we created models of angiogenesis, the blood-brain-barrier (BBB), and tumor-cell extravasation. Our angiogenesis model recapitulates true angiogenesis, in which sprouting occurs from a “parent” vessel in response to a gradient of growth factors. Our BBB model is composed of a microvessel generated from brain-specific endothelial cells (ECs) within an ECM populated with astrocytes and pericytes. Our tumor-cell extravasation model can be utilized to visualize and measure tumor-cell migration through vessel walls into the surrounding matrix. The described

  9. Procurement and control of spare and replacement parts - a regulatory perspective

    International Nuclear Information System (INIS)

    Baker, E.T.; Grimes, B.K.; Merschoff, E.W.

    1987-01-01

    As the nuclear industry shifts from a construction to an operations orientation, a number of fundamental changes have occurred in the type of safety-related procurements and the manner in which the utilities accomplish these procurements. Specifically, procurements have shifted from the purchase of large systems and components by architect-engineers, and nuclear steam supply system (NSSS) suppliers to the procurement by utilities of subassemblies, individual pieces of equipment (e.g., breakers, relays), and small parts for repairing individual pieces of equipment. To ensure that equipment will continue to perform its intended function and to satisfy regulatory requirements utilities must consider several things: (1) does the equipment perform a safety function; (2) does the replacement part affect the safety function; and (3) does the replacement part affect the seismic or environmental qualification. If the answer to any of these questions is yes, the purchaser has two alternatives. He may procure the item as safety-related and require the supplier or manufacturer to comply with all the applicable technical and quality requirements or he may purchase the item commercial grade and perform the necessary inspections and tests to ensure the item meets the requirements, i.e., dedicate the item

  10. Economic theory and the application of incentive contracts to procure operating reserves

    International Nuclear Information System (INIS)

    Wang, L.; Yu, C.W.; Wen, F.S.

    2007-01-01

    The ancillary services market plays an important role in the operation of an electricity market, especially for achieving a high level of reliability. Among all ancillary services, operating reserve is an important research focus, with the attention mainly on the optional procurement and pricing methods. These methods differ in many aspects, including the objective, allocation of risks, and feasibility. In this paper, a new approach is proposed to analyze the users' reserve procurement problem and a novel reserve trade mechanism is developed between electricity users and the retailer of the market. First, the differences between the procurement of operating reserve in decentralized and centralized ways are analyzed. The comparison of the equilibrium solutions reveals that the centralized procurement that results in a systemic optimal solution is better than the decentralized procurement that results in a Nash equilibrium solution. Furthermore, an incentive contract based on a Principal-agent model, that is able to induce a systemic optimality as well as a Pareto equilibrium and manage risks at the same time is designed. The proposed model is equitable and beneficial to all participants. An example is served to illustrate the features of the model and the methodology. (author)

  11. Interactions between adipose tissue and the immune system in health and malnutrition.

    Science.gov (United States)

    Wensveen, Felix M; Valentić, Sonja; Šestan, Marko; Wensveen, Tamara Turk; Polić, Bojan

    2015-09-01

    Adipose tissue provides the body with a storage depot of nutrients that is drained during times of starvation and replenished when food sources are abundant. As such, it is the primary sensor for nutrient availability in the milieu of an organism, which it communicates to the body through the excretion of hormones. Adipose tissue regulates a multitude of body functions associated with metabolism, such as gluconeogenesis, feeding and nutrient uptake. The immune system forms a vital layer of protection against micro-organisms that try to gain access to the nutrients contained in the body. Because infections need to be resolved as quickly as possible, speed is favored over energy-efficiency in an immune response. Especially when immune cells are activated, they switch to fast, but energy-inefficient anaerobic respiration to fulfill their energetic needs. Despite the necessity for an effective immune system, it is not given free rein in its energy expenditure. Signals derived from adipose tissue limit immune cell numbers and activity under conditions of nutrient shortage, whereas they allow proper immune cell activity when food sources are sufficiently available. When excessive fat accumulation occurs, such as in diet-induced obesity, adipose tissue becomes the site of pathological immune cell activation, causing chronic low-grade systemic inflammation. Obesity is therefore associated with a number of disorders in which the immune system plays a central role, such as atherosclerosis and non-alcoholic steatohepatitis. In this review, we will discuss the way in which adipose tissue regulates activity of the immune system under healthy and pathological conditions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Regulatory Powers in Public Procurement Law of Peruvian Administrative Agencies

    Directory of Open Access Journals (Sweden)

    Juan Carlos Morón Urbina

    2017-12-01

    Full Text Available Peruvian law has explicitly recognized regulatory powers to administrative agencies, which allows them to have a preponderant role in the production of rules in public procurement. Although these delegations of legislative authority are positively defined, distortions in the system of legal sources arise when agencies exceed delegated powers or when measures issued by administrative entities are mistaken for regulations. This paper aims to identify regulatory powers of Peruvian administrative agencies, as well as the regulatory measures they issue, and their relation with other sources of law.

  13. Forward Commitment Procurement : A practical methodology that helps to manage risk in procuring innovative goods and services

    NARCIS (Netherlands)

    Whyles, G.; Meerveld, H. van; Nauta, N.J.

    2015-01-01

    The Forward Commitment Procurement (FCP) is a Public Procurement of Innovation (PPI) methodology. It was specifically designed to both provide a practical methodology for procurers to follow and to manage the perceived risk of the customer and supplier in innovation investments. The paper describes

  14. Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology.

    Science.gov (United States)

    Akiyama, Toru; Tanaka, Sakae

    2011-08-01

    One of the most important roles of apoptosis is the maintenance of tissue homeostasis. Impairment of apoptosis leads to a number of pathological conditions. In response to apoptotic signals, various proteins are activated in a pathway and signal-specific manner. Recently, the pro-apoptotic molecule Bim has attracted increasing attention as a pivotal regulator of tissue homeostasis. The Bim expression level is strictly controlled in both transcriptional and post-transcriptional levels. This control is dependent on cell, tissue and apoptotic stimuli. The phenotype of Bim-deficient mice is a systemic lupus erythematosus-like autoimmune disease with an abnormal accumulation of hematopoietic cells. Bim is thus a critical regulator of hematopoietic cells and immune system. Further studies have revealed the critical roles of Bim in various normal and pathological conditions, including bone homeostasis and tumorigenesis. The current understanding of Bim signaling and roles in the maintenance of tissue homeostasis is reviewed in this paper, focusing on the immune system, bone biology and tumorigenesis to illustrate the diversified role of Bim.

  15. Application of the ultrasound hyperthermia model for a multi-layered tissue system

    International Nuclear Information System (INIS)

    Loerincz, A

    2004-01-01

    This work models the thermal effect of several planar transducers targeting the tumour interactively in a ceramics-coupling-skin-muscle-tumour system. The most important inputs of the model include the following: emitted electric output, J/s; mechanical efficiency, %; number of transducers, pieces; surface area of the transducer, m 2 ; area, m 2 and temperature, K of the cooling surface, attenuation coefficients, Np/cm MHz; specific heats, J/gK; densities, g/cm 3 ; heat conductivities, J/msK; sound velocities m/s; flow rate of blood in the tissues, ml/gtissue/min; sound path in the tissues and in the blood flowing through the tissues, m. From the inputs, a number of intermediate data are determined, e.g. the geometry of the irradiated bodies that are in the path of ultrasound, acoustic hardness, Pas/m; sound reflection and sound transmission occurring at the interfaces, Np; heat exchanger wall thickness of the irradiated bodies, m; heat dissipation and heat exchanger surface areas, m 2 ; flow rate of blood in the tissues located in the path of ultrasound, ml/tissue mass in g/min; and the sound attenuation of the tissues, Np. The amount of generated heat, K/s decreased by the heat energy transported, J/s to the surrounding tissues by blood and heat conductivity, and the actual temperature, K of the irradiated tissue are the output parameters calculated by the model. The output results are available in the form of functions. The expected temperature of the target area, K can be set to either the denaturation temperature or to the respiratory decomposition temperature (43.5 deg. C) without damaging the surrounding tissues by setting in the following parameters properly: electric output power, W; the number and surface area, m 2 of the transducers; the area, m 2 and temperature, K of the cooling surfaces. After further development, the model will be suitable for handling more than three tissue layers, increased blood flow rates different angles of incidence, and

  16. A new method for E-government procurement using collaborative filtering and Bayesian approach.

    Science.gov (United States)

    Zhang, Shuai; Xi, Chengyu; Wang, Yan; Zhang, Wenyu; Chen, Yanhong

    2013-01-01

    Nowadays, as the Internet services increase faster than ever before, government systems are reinvented as E-government services. Therefore, government procurement sectors have to face challenges brought by the explosion of service information. This paper presents a novel method for E-government procurement (eGP) to search for the optimal procurement scheme (OPS). Item-based collaborative filtering and Bayesian approach are used to evaluate and select the candidate services to get the top-M recommendations such that the involved computation load can be alleviated. A trapezoidal fuzzy number similarity algorithm is applied to support the item-based collaborative filtering and Bayesian approach, since some of the services' attributes can be hardly expressed as certain and static values but only be easily represented as fuzzy values. A prototype system is built and validated with an illustrative example from eGP to confirm the feasibility of our approach.

  17. A New Method for E-Government Procurement Using Collaborative Filtering and Bayesian Approach

    Directory of Open Access Journals (Sweden)

    Shuai Zhang

    2013-01-01

    Full Text Available Nowadays, as the Internet services increase faster than ever before, government systems are reinvented as E-government services. Therefore, government procurement sectors have to face challenges brought by the explosion of service information. This paper presents a novel method for E-government procurement (eGP to search for the optimal procurement scheme (OPS. Item-based collaborative filtering and Bayesian approach are used to evaluate and select the candidate services to get the top-M recommendations such that the involved computation load can be alleviated. A trapezoidal fuzzy number similarity algorithm is applied to support the item-based collaborative filtering and Bayesian approach, since some of the services’ attributes can be hardly expressed as certain and static values but only be easily represented as fuzzy values. A prototype system is built and validated with an illustrative example from eGP to confirm the feasibility of our approach.

  18. European technology activities to prepare for ITER component procurement

    International Nuclear Information System (INIS)

    Gasparotto, M.

    2006-01-01

    Over the past few years the technology activities of the European fusion programme have principally been devoted to: a) the completion of design and R (and) D studies in preparation for the procurement of ITER systems and components in close collaboration with the ITER team and according to the ITER design and schedule; b) provision of support to European industry and associations in key areas of fusion R (and) D to ensure a competitive and timely approach to the planned procurement. The EU contribution to ITER design and R (and) D activities has been maintained at a significant level with the objectives of: · continuing, and in some areas expanding, the effort in areas where design and R (and)D are still required: in particular in Machine Assembly, Remote Handling, ITER Test Blanket Modules, Diagnostics, Heating and Current Drive Systems. · continuing and completing manufacturing R (and)D to determine the most technically and cost affective manufacturing methods for ITER components to be built in Europe. · preparing new test facilities needed during ITER construction (DIPOLE, HELOKA, DTP-2, ECRH Test Facility, Fatigue Testing Facility). · supporting the European site preparation process and the preparation of safety and licensing documentation for ITER in Cadarache. · maintaining support to EU industries in R (and) D activities of relevance to fusion. To support the ITER Design activities and to prepare for the provision of timely answers to key issues, which may be raised during the ITER design review, support from specialized companies has been set-up in the fields of Civil and General Plant Engineering, Mechanical Engineering / Components, Mechanical Engineering / Systems (and) Plants, Remote Handling (and) Assembly, Electrical Engineering, Nuclear Safety Engineering. In recent years major efforts have been directed towards the technology development of the ITER components for which procurement can be launched during the first years of the construction

  19. Lacrimal drainage-associated lymphoid tissue (LDALT): a part of the human mucosal immune system.

    Science.gov (United States)

    Knop, E; Knop, N

    2001-03-01

    Mucosa-associated lymphoid tissue (MALT) specifically protects mucosal surfaces. In a previous study of the human conjunctiva, evidence was also found for the presence of MALT in the lacrimal sac. The present study, therefore, aims to investigate its morphology and topographical distribution in the human lacrimal drainage system. Lacrimal drainage systems (n = 51) obtained from human cadavers were investigated by clearing flat wholemounts or by serial sections of tissue embedded in paraffin, OCT compound, or epoxy resin. These were further analyzed by histology, immunohistochemistry, and electron microscopy. All specimens showed the presence of lymphocytes and plasma cells as a diffuse lymphoid tissue in the lamina propria, together with intraepithelial lymphocytes and occasional high endothelial venules (HEV). It formed a narrow layer along the canaliculi that became thicker in the cavernous parts. The majority of lymphocytes were T cells, whereas B cells were interspersed individually or formed follicular centers. T cells were positive for CD8 and the human mucosa lymphocyte antigen (HML-1). Most plasma cells were positive for IgA and the overlying epithelium expressed its transporter molecule secretory component (SC). Basal mucous glands were present in the lacrimal canaliculi and in the other parts accompanied by alveolar and acinar glands, all producing IgA-rich secretions. Primary and secondary lymphoid follicles possessing HEV were present in about half of the specimens. The term lacrimal drainage-associated lymphoid tissue (LDALT) is proposed here to describe the lymphoid tissue that is regularly present and belongs to the common mucosal immune system and to the secretory immune system. It is suggested that it may form a functional unit together with the lacrimal gland and conjunctiva, connected by tear flow, lymphocyte recirculation, and probably the neural reflex arc, and play a major role in preserving ocular surface integrity.

  20. Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system.

    Science.gov (United States)

    Elliott Donaghue, Irja; Tam, Roger; Sefton, Michael V; Shoichet, Molly S

    2014-09-28

    Tissue engineering frequently involves cells and scaffolds to replace damaged or diseased tissue. It originated, in part, as a means of effecting the delivery of biomolecules such as insulin or neurotrophic factors, given that cells are constitutive producers of such therapeutic agents. Thus cell delivery is intrinsic to tissue engineering. Controlled release of biomolecules is also an important tool for enabling cell delivery since the biomolecules can enable cell engraftment, modulate inflammatory response or otherwise benefit the behavior of the delivered cells. We describe advances in cell and biomolecule delivery for tissue regeneration, with emphasis on the central nervous system (CNS). In the first section, the focus is on encapsulated cell therapy. In the second section, the focus is on biomolecule delivery in polymeric nano/microspheres and hydrogels for the nerve regeneration and endogenous cell stimulation. In the third section, the focus is on combination strategies of neural stem/progenitor cell or mesenchymal stem cell and biomolecule delivery for tissue regeneration and repair. In each section, the challenges and potential solutions associated with delivery to the CNS are highlighted. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Establishment of the optimum two-dimensional electrophoresis system of ovine ovarian tissue.

    Science.gov (United States)

    Jia, J L; Zhang, L P; Wu, J P; Wang, J; Ding, Q

    2014-08-26

    Lambing performance of sheep is the most important economic trait and is regarded as a critic factoring affecting the productivity in sheep industry. Ovary plays the most roles in lambing trait. To establish the optimum two-dimensional electrophoresis system (2-DE) of ovine ovarian tissue, the common protein extraction methods of animal tissue (trichloroacetic acid/acetone precipitation and direct schizolysis methods) were used to extract ovine ovarian protein, and 17-cm nonlinear immobilized PH 3-10 gradient strips were used for 2-DE. The sample handling, loading quantity of the protein sample, and isoelectric focusing (IEF) steps were manipulated and optimized in this study. The results indicate that the direct schizolysis III method, a 200-μg loading quantity of the protein sample, and IEF steps II (20°C active hydration, 14 h→500 V, 1 h→1000 V 1 h→1000-9000 V, 6 h→80,000 VH→500 V 24 h) are optimal for 2-DE analysis of ovine ovarian tissue. Therefore, ovine ovarian tissue proteomics 2-DE was preliminarily established by the optimized conditions in this study; meanwhile, the conditions identified herein could provide a reference for ovarian sample preparation and 2-DE using tissues from other animals.

  2. Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue.

    Science.gov (United States)

    Shi, Yan-Chuan; Baldock, Paul A

    2012-02-01

    Skeletal research is currently undergoing a period of marked expansion. The boundaries of "bone" research are being re-evaluated and with this, a growing recognition of a more complex and interconnected biology than previously considered. One aspect that has become the focus of particular attention is the relationship between bone and fat homeostasis. Evidence from a number of avenues indicates that bone and adipose regulation are both related and interdependent. This review examines the neuropeptide Y (NPY) system, known to exert powerful control over both bone and fat tissue. The actions of this system are characterized by signaling both within specific nuclei of the hypothalamus and also the target tissues, mediated predominantly through two G-protein coupled receptors (Y1 and Y2). In bone tissue, elevated NPY levels act consistently to repress osteoblast activity. Moreover, both central Y2 receptor and osteoblastic Y1 receptor signaling act similarly to repress bone formation. Conversely, loss of NPY expression or receptor signaling induces increased osteoblast activity and bone mass in both cortical and cancellous envelopes. In fat tissue, NPY action is more complex. Energy homeostasis is powerfully altered by elevations in hypothalamic NPY, resulting in increases in fat accretion and body-wide energy conservation, through the action of locally expressed Y1 receptors, while local Y2 receptors act to inhibit NPY-ergic tone. Loss of central NPY expression has a markedly reduced effect, consistent with a physiological drive to promote fat accretion. In fat tissue, NPY and Y1 receptors act to promote lipogenesis, consistent with their roles in the brain. Y2 receptors expressed in adipocytes also act in this manner, showing an opposing action to their role in the hypothalamus. While direct investigation of these processes has yet to be completed, these responses appear to be interrelated to some degree. The starvation-based signal of elevated central NPY inducing

  3. The problems of accountable and analytical procuring of enterprise management

    Directory of Open Access Journals (Sweden)

    Kovalova Tatiana Volodymyrivna

    2016-02-01

    Full Text Available This article investigated main aspects of accountable and analytical procuring of enterprise management. It was found essence of accountable and analytical procuring of enterprise management, purpose, functions and tasks. It was determined main elements and essence of accountable and analytical information taking into consideration needs of modern management. In the article are exposed structural elements of accountable and analytical procuring. It was formed conceptual approaches of building accountable and analytical procuring of enterprise management. It was analyzed main problems of improving accountable and analytical informational procuring of taking managerial decisions with the aim of solving economic problems due to current situation of national economy.

  4. Public perspectives on biospecimen procurement: what biorepositories should consider.

    Science.gov (United States)

    L'Heureux, Jamie; Murray, Jeffrey C; Newbury, Elizabeth; Shinkunas, Laura; Simon, Christian M

    2013-06-01

    Human biospecimens are central to biobanking efforts, yet how members of the public think about biobank procurement strategies is not well understood. This study aimed to explore public perspectives toward the procurement of residual clinical material versus "direct" procurement strategies such as the drawing of blood. Members of the public residing in and beyond the biobank catchment area of the University of Iowa Hospitals and Clinics were randomly selected to participate in focus groups and a telephone survey. The majority of survey participants (75%, n=559) found both residual and direct procurement strategies equally workable. Small proportions preferred either residual (15%; n=117) or direct (5%; n=40) procurement. Focus group participants (n=48) could identify benefits to both procurement strategies, but raised concerns about possible donor inconvenience/discomfort and reduced biospecimen accrual in the case of direct procurement. Residual procurement raised concerns about lower-quality samples being procured without full donor awareness. Biobanks should consider that members of the public in their research programs may be willing to make specimen donations regardless of whether a residual or direct procurement strategy is employed. Limiting patient discomfort and inconvenience may make direct procurement strategies more acceptable to some members of the public. Ensuring donor awareness through effective informed consent may allay public concerns about the indirectness of donating clinical biospecimens.

  5. EIA and green procurement: Opportunities for strengthening their coordination

    International Nuclear Information System (INIS)

    Uttam, Kedar; Faith-Ell, Charlotta; Balfors, Berit

    2012-01-01

    EIA plays an important role in enhancing the environmental performance of the construction sector. In recent years, the construction sector has been developing green procurement practices. Green procurement is a process that involves the incorporation of environmental requirements during the procurement of services and products. However, discussion on green procurement is rarely seen during the EIA phase. This paper addresses possible opportunities for improving the coordination between EIA and green procurement within the construction sector. The linking of EIA and green procurement has been postulated in the paper as an aid to strengthen the coordination between project planning and implementation. The paper is based on a literature review and is an outcome of an on-going research project concerning EIA and green procurement. This study indicated that it would be appropriate to introduce green procurement during the pre-decision phase of an EIA. In the present study, the opportunities for integrating green procurement at the stage of EIA are associated with the integration of project planning and EIA. Future research should investigate the mechanism through which the link can be established. - Highlights: ► This paper identifies opportunities to link EIA and green procurement. ► Pre-decision phase of EIA could be appropriate for planning green procurement. ► Future research should investigate the mechanism for establishing the link.

  6. EIA and green procurement: Opportunities for strengthening their coordination

    Energy Technology Data Exchange (ETDEWEB)

    Uttam, Kedar, E-mail: kedar@kth.se [Department of Land and Water Resources Engineering, Royal Institute of Technology, Stockholm (Sweden); Faith-Ell, Charlotta, E-mail: charlotta.faith-ell@WSPGroup.se [WSP Sweden (Sweden); Balfors, Berit, E-mail: balfors@kth.se [Department of Land and Water Resources Engineering, Royal Institute of Technology, Stockholm (Sweden)

    2012-02-15

    EIA plays an important role in enhancing the environmental performance of the construction sector. In recent years, the construction sector has been developing green procurement practices. Green procurement is a process that involves the incorporation of environmental requirements during the procurement of services and products. However, discussion on green procurement is rarely seen during the EIA phase. This paper addresses possible opportunities for improving the coordination between EIA and green procurement within the construction sector. The linking of EIA and green procurement has been postulated in the paper as an aid to strengthen the coordination between project planning and implementation. The paper is based on a literature review and is an outcome of an on-going research project concerning EIA and green procurement. This study indicated that it would be appropriate to introduce green procurement during the pre-decision phase of an EIA. In the present study, the opportunities for integrating green procurement at the stage of EIA are associated with the integration of project planning and EIA. Future research should investigate the mechanism through which the link can be established. - Highlights: Black-Right-Pointing-Pointer This paper identifies opportunities to link EIA and green procurement. Black-Right-Pointing-Pointer Pre-decision phase of EIA could be appropriate for planning green procurement. Black-Right-Pointing-Pointer Future research should investigate the mechanism for establishing the link.

  7. Monitoring What Governments “Give for” and “Spend on” Vaccine Procurement: Vaccine Procurement Assistance and Vaccine Procurement Baseline

    OpenAIRE

    Nelson, E. A. S.; Bloom, David E.; Mahoney, Richard T.

    2014-01-01

    BACKGROUND: The Global Vaccine Action Plan will require, inter alia, the mobilization of financial resources from donors and national governments - both rich and poor. Vaccine Procurement Assistance (VPA) and Vaccine Procurement Baseline (VPB) are two metrics that could measure government performance and track resources in this arena. VPA is proposed as a new subcategory of Official Development Assistance (ODA) given for the procurement of vaccines and VPB is a previously suggested measure of...

  8. Cross-national research on contractor evaluation procedures in public works procurement

    Science.gov (United States)

    Kinoshita, Seiya; Sato, Naoyoshi; Matsumoto, Naoya

    Contractor evaluation methods in Japan's public works procurement, beginning with construction business licensure, going through biennial preliminary firm rating, up to project-by-project prequalification and comprehensive point rating, were developed during the period when public works were mostly procured through designated competitive bidding. It is essential to focus attention on contractor evaluation methods for introducing different types of procurement procedures which enhance the use of technological capabilities held by private businesses. An overall review of contractor evaluation procedures should be conducted in view of the present situation, where the open competitive bidding has become mainly used in combination with comprehensive evaluation, as well as to allow for further diversification of procurement methods. In Western countries, improvements have been made for the past several years in contractor evaluation procedures with more emphasis on "Value for Money." Advanced efforts made by these countries will be useful as a reference for overhauling Japan's contractor evaluation system. This study conducts a comparative review of contractor evaluation procedures for public procurement in Western countries such as the United States, the United Kingdom and France by identifying similarities and differences between those of Japan and the above mentioned countries. This reveals that a contractor's technical or professional ability is looked at separately from its economic and financial standing in those countries studied, and there is no case like Japan in which those two factors are integrated into one for evaluation.

  9. Overview on zein protein: a promising pharmaceutical excipient in drug delivery systems and tissue engineering.

    Science.gov (United States)

    Labib, Gihan

    2018-01-01

    Natural pharmaceutical excipients have been applied extensively in the past decades owing to their safety and biocompatibility. Zein, a natural protein of plant origin offers great benefit over other synthetic polymers used in controlled drug and biomedical delivery systems. It was used in a variety of medical fields including pharmaceutical and biomedical drug targeting, vaccine, tissue engineering, and gene delivery. Being biodegradable and biocompatible, the current review focuses on the history and the medical application of zein as an attractive still promising biopolymer. Areas covered: The current review gives a broadscope on zein as a still promising protein excipient in different fields. Zein- based drug and biomedical delivery systems are discussed with special focus on current and potential application in controlled drug delivery systems, and tissue engineering. Expert opinion: Zein as a protein of natural origin can still be considered a promising polymer in the field of drug delivery systems as well as in tissue engineering. Although different researchers spotted light on zein application in different industrial fields extensively, the feasibility of its use in the field of drug delivery replenished by investigators in recent years has not yet been fully approached.

  10. Portable, Fiber-Based, Diffuse Reflection Spectroscopy (DRS) Systems for Estimating Tissue Optical Properties.

    Science.gov (United States)

    Vishwanath, Karthik; Chang, Kevin; Klein, Daniel; Deng, Yu Feng; Chang, Vivide; Phelps, Janelle E; Ramanujam, Nimmi

    2011-02-01

    Steady-state diffuse reflection spectroscopy is a well-studied optical technique that can provide a noninvasive and quantitative method for characterizing the absorption and scattering properties of biological tissues. Here, we compare three fiber-based diffuse reflection spectroscopy systems that were assembled to create a light-weight, portable, and robust optical spectrometer that could be easily translated for repeated and reliable use in mobile settings. The three systems were built using a broadband light source and a compact, commercially available spectrograph. We tested two different light sources and two spectrographs (manufactured by two different vendors). The assembled systems were characterized by their signal-to-noise ratios, the source-intensity drifts, and detector linearity. We quantified the performance of these instruments in extracting optical properties from diffuse reflectance spectra in tissue-mimicking liquid phantoms with well-controlled optical absorption and scattering coefficients. We show that all assembled systems were able to extract the optical absorption and scattering properties with errors less than 10%, while providing greater than ten-fold decrease in footprint and cost (relative to a previously well-characterized and widely used commercial system). Finally, we demonstrate the use of these small systems to measure optical biomarkers in vivo in a small-animal model cancer therapy study. We show that optical measurements from the simple portable system provide estimates of tumor oxygen saturation similar to those detected using the commercial system in murine tumor models of head and neck cancer.

  11. How does the knowledge environment shape procurement practices for orthopaedic medical devices in Mexico?

    Science.gov (United States)

    Lingg, Myriam; Wyss, Kaspar; Durán-Arenas, Luis

    2016-07-08

    In organisational theory there is an assumption that knowledge is used effectively in healthcare systems that perform well. Actors in healthcare systems focus on managing knowledge of clinical processes like, for example, clinical decision-making to improve patient care. We know little about connecting that knowledge to administrative processes like high-risk medical device procurement. We analysed knowledge-related factors that influence procurement and clinical procedures for orthopaedic medical devices in Mexico. We based our qualitative study on 48 semi-structured interviews with various stakeholders in Mexico: orthopaedic specialists, government officials, and social security system managers or administrators. We took a knowledge-management related perspective (i) to analyse factors of managing knowledge of clinical procedures, (ii) to assess the role of this knowledge and in relation to procurement of orthopaedic medical devices, and (iii) to determine how to improve the situation. The results of this study are primarily relevant for Mexico but may also give impulsion to other health systems with highly standardized procurement practices. We found that knowledge of clinical procedures in orthopaedics is generated inconsistently and not always efficiently managed. Its support for procuring orthopaedic medical devices is insufficient. Identified deficiencies: leaders who lack guidance and direction and thus use knowledge poorly; failure to share knowledge; insufficiently defined formal structures and processes for collecting information and making it available to actors of health system; lack of strategies to benefit from synergies created by information and knowledge exchange. Many factors are related directly or indirectly to technological aspects, which are insufficiently developed. The content of this manuscript is novel as it analyses knowledge-related factors that influence procurement of orthopaedic medical devices in Mexico. Based on our results we

  12. Comparison of tissue damage caused by various laser systems with tissue tolerable plasma by light and laser scan microscopy

    International Nuclear Information System (INIS)

    Vandersee, Staffan; Lademann, Jürgen; Richter, Heike; Patzelt, Alexa; Lange-Asschenfeldt, Bernhard

    2013-01-01

    Tissue tolerable plasma (TTP) represents a novel therapeutic method with promising capabilities in the field of dermatological interventions, in particular disinfection but also wound antisepsis and regeneration. The energy transfer by plasma into living tissue is not easily educible, as a variety of features such as the medium’s actual molecule-stream, the ions, electrons and free radicals involved, as well as the emission of ultraviolet, visible and infrared light contribute to its increasingly well characterized effects. Thus, relating possible adversary effects, especially of prolonged exposure to a single component of the plasma’s mode of action, is difficult. Until now, severe adverse events connected to plasma exposure have not been reported when conducted according to existing therapeutic protocols. In this study, we have compared the tissue damage-potential of CO 2 and dye lasers with TTP in a porcine model. After exposure of pig ear skin to the three treatment modalities, all specimens were examined histologically and by means of laser scan microscopy (LSM). Light microscopical tissue damage could only be shown in the case of the CO 2 laser, whereas dye laser and plasma treatment resulted in no detectable impairment of the specimens. In the case of TTP, LSM examination revealed only an impairment of the uppermost corneal layers of the skin, thus stressing its safety when used in vivo. (letter)

  13. Benchmarking the Performance of Construction Procurement Methods against Selection Criteria in Nigeria

    Directory of Open Access Journals (Sweden)

    Stephen Okunlola Ojo

    2009-01-01

    Full Text Available The study developed performance indices by the widely used procurement options in Nigeria on selection criteria. The traditional mean and standardized ratio were used to form the utility coefficients. Results revealed that performance by the procurement options depended on the respondents’ categorization and cost categorization of projects. Public clients ranked the lump sum contracts more able to achieve speed for projects up to N100 million (Naira while the private clients believe it is the design-build. As regards quality, public clients rated the Build-Own-Operate-Transfer (BOOT system as most able to achieve the quality criterion whereas private clients rated design-build for projects up to N100 million (Naira. The study then concluded that, in the Nigerian construction industry participants do not agree on the performance of the procurement options on selection criteria.

  14. Improved system for identifying biological tissue temperature using electrical impedance tomography

    Directory of Open Access Journals (Sweden)

    Korolyuk Evgeniy

    2018-01-01

    Full Text Available This paper proposes a cheap and compact medical system that determines the temperature of an object using broadband impedance tomography. This system can be used in medicine to visualize ice structure in tissue during cryosurgical operations, as well as for fault diagnosis and location in studied industrial objects. These effects are achieved by measuring electrical impedance between electrode pairs in the measuring chamber. The assembled prototype is compact, consumes little power, and allows to non-invasively determine the impedance of a target object in real time. The research included experimental studies to determine the dependence of the impedance spectrum of saline water and muscle tissue on temperature in broad band spectrum, which allowed to obtain the dependence of total electrical impedance of target objects on temperature.

  15. The application of Fourier transform infrared microspectroscopy for the study of diseased central nervous system tissue.

    Science.gov (United States)

    Caine, Sally; Heraud, Philip; Tobin, Mark J; McNaughton, Donald; Bernard, Claude C A

    2012-02-15

    In the last two decades the field of infrared spectroscopy has seen enormous advances in both instrumentation and the development of bioinformatic methods for spectral analysis, allowing the examination of a large variety of healthy and diseased samples, including biological fluids, isolated cells, whole tissues, and tissue sections. The non-destructive nature of the technique, together with the ability to directly probe biochemical changes without the addition of stains or contrast agents, enables a range of complementary analyses. This review focuses on the application of Fourier transform infrared (FTIR) microspectroscopy to analyse central nervous system tissues, with the aim of understanding the biochemical and structural changes associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, transmissible spongiform encephalopathies, multiple sclerosis, as well as brain tumours. Modern biospectroscopic methods that combine FTIR microspectroscopy with bioinformatic analysis constitute a powerful new methodology that can discriminate pathology from normal healthy tissue in a rapid, unbiased fashion, with high sensitivity and specificity. Notably, the ability to detect protein secondary structural changes associated with Alzheimer's plaques, neurons in Parkinson's disease, and in some spectra from meningioma, as well as in the animal models of Alzheimer's disease, transmissible spongiform encephalopathies, and multiple sclerosis, illustrates the power of this technology. The capacity to offer insight into the biochemical and structural changes underpinning aetio-pathogenesis of diseases in tissues provides both a platform to investigate early pathologies occurring in a variety of experimentally induced and naturally occurring central nervous system diseases, and the potential to evaluate new therapeutic approaches. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. Deemed consent: Assessing the new opt-out approach to organ procurement in Wales

    DEFF Research Database (Denmark)

    Albertsen, Andreas

    2018-01-01

    In December 2015, Wales became the first country in the UK to move away from an opt-in system in organ procurement. The new legislation introduces the concept of deemed consent whereby a person who neither opt in nor opt out is deemed to have consented to donation. The data released by the National...... Health Service (NHS) in July 2017 provide an excellent opportunity to assess this legislation in light of concerns that it would decrease procurement rates for living and deceased donation, as well as sparking an increase in family refusals. None of these concerns have come to pass, with Wales...

  17. Evaluation of an automated connective tissue disease screening assay in Korean patients with systemic rheumatic diseases.

    Directory of Open Access Journals (Sweden)

    Seri Jeong

    Full Text Available This study aimed to evaluate the diagnostic utilities of the automated connective tissues disease screening assay, CTD screen, in patients with systemic rheumatic diseases. A total of 1093 serum samples were assayed using CTD screen and indirect immunofluorescent (IIF methods. Among them, 162 were diagnosed with systemic rheumatic disease, including rheumatoid arthritis (RA, systemic lupus erythematosus (SLE, and mixed connective tissue disease (MCT. The remaining 931 with non-systemic rheumatic disease were assigned to the control group. The median ratios of CTD screen tests were significantly higher in the systemic rheumatic disease group than in the control group. The positive likelihood ratios of the CTD screen were higher than those of IIF in patients with total rheumatic diseases (4.1 vs. 1.6, including SLE (24.3 vs. 10.7. The areas under the receiver operating characteristic curves (ROC-AUCs of the CTD screen for discriminating total rheumatic diseases, RA, SLE, and MCT from controls were 0.68, 0.56, 0.92 and 0.80, respectively. The ROC-AUCs of the combinations with IIF were significantly higher in patients with total rheumatic diseases (0.72 and MCT (0.85 than in those of the CTD screen alone. Multivariate analysis indicated that both the CTD screen and IIF were independent variables for predicting systemic rheumatic disease. CTD screen alone and in combination with IIF were a valuable diagnostic tool for predicting systemic rheumatic diseases, particularly for SLE.

  18. Evaluation of an automated connective tissue disease screening assay in Korean patients with systemic rheumatic diseases.

    Science.gov (United States)

    Jeong, Seri; Yang, Heeyoung; Hwang, Hyunyong

    2017-01-01

    This study aimed to evaluate the diagnostic utilities of the automated connective tissues disease screening assay, CTD screen, in patients with systemic rheumatic diseases. A total of 1093 serum samples were assayed using CTD screen and indirect immunofluorescent (IIF) methods. Among them, 162 were diagnosed with systemic rheumatic disease, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCT). The remaining 931 with non-systemic rheumatic disease were assigned to the control group. The median ratios of CTD screen tests were significantly higher in the systemic rheumatic disease group than in the control group. The positive likelihood ratios of the CTD screen were higher than those of IIF in patients with total rheumatic diseases (4.1 vs. 1.6), including SLE (24.3 vs. 10.7). The areas under the receiver operating characteristic curves (ROC-AUCs) of the CTD screen for discriminating total rheumatic diseases, RA, SLE, and MCT from controls were 0.68, 0.56, 0.92 and 0.80, respectively. The ROC-AUCs of the combinations with IIF were significantly higher in patients with total rheumatic diseases (0.72) and MCT (0.85) than in those of the CTD screen alone. Multivariate analysis indicated that both the CTD screen and IIF were independent variables for predicting systemic rheumatic disease. CTD screen alone and in combination with IIF were a valuable diagnostic tool for predicting systemic rheumatic diseases, particularly for SLE.

  19. Role of the immune system in cardiac tissue damage and repair following myocardial infarction.

    Science.gov (United States)

    Saparov, Arman; Ogay, Vyacheslav; Nurgozhin, Talgat; Chen, William C W; Mansurov, Nurlan; Issabekova, Assel; Zhakupova, Jamilya

    2017-09-01

    The immune system plays a crucial role in the initiation, development, and resolution of inflammation following myocardial infarction (MI). The lack of oxygen and nutrients causes the death of cardiomyocytes and leads to the exposure of danger-associated molecular patterns that are recognized by the immune system to initiate inflammation. At the initial stage of post-MI inflammation, the immune system further damages cardiac tissue to clear cell debris. The excessive production of reactive oxygen species (ROS) by immune cells and the inability of the anti-oxidant system to neutralize ROS cause oxidative stress that further aggravates inflammation. On the other hand, the cells of both innate and adaptive immune system and their secreted factors are critically instrumental in the very dynamic and complex processes of regulating inflammation and mediating cardiac repair. It is important to decipher the balance between detrimental and beneficial effects of the immune system in MI. This enables us to identify better therapeutic targets for reducing the infarct size, sustaining the cardiac function, and minimizing the likelihood of heart failure. This review discusses the role of both innate and adaptive immune systems in cardiac tissue damage and repair in experimental models of MI.

  20. Collaborative procurement for developing a sustainable campus

    Science.gov (United States)

    Nifa, Faizatul Akmar Abdul; Rahim, Syukran Abdul; Rani, Wan Nurul Mardiah Wan Mohd; Ismail, Mohd. Noorizhar

    2016-08-01

    It is particularly challenging to achieve sustainability in campus universities, where a high volume of users and activities has made it more imperative to promote green buildings that reduce energy and water consumption while having a minimal carbon footprint. At present, the frameworks for sustainable campus have seldom focused on the project procurement method which would improve construction team integration in developing the physical aspect of campus development. Therefore, in response to that challenge, this paper investigates how the delivery team, responsible for the design and construction of a project, can be integrated to work together more efficiently and more using the collaborative procurement method known as partnering. This paper reports part of a previous research and sets the base for ongoing research on the critical factors in partnering for sustainable campus development. The outcome or result of this study will meet and support the requirement for construction, maintenance, and operation process for universities towards sustainable building/campus in the future.