Transcriptome analysis of Phelipanche aegyptiaca seed germination mechanisms stimulated by fluridone, TIS108, and GR24.

Directory of Open Access Journals (Sweden)

Ya Zhou Bao

Full Text Available P. aegyptiaca is one of the most destructive root parasitic plants worldwide, causing serious damage to many crop species. Under natural conditions P. aegyptiaca seeds must be conditioned and then stimulated by host root exudates before germinating. However, preliminary experiments indicated that TIS108 (a triazole-type inhibitor of strigolactone and fluridone (FL, an inhibitor of carotenoid-biosynthesis both stimulated the germination of P. aegyptiaca seeds without a water preconditioning step (i.e. unconditioned seeds. The objective of this study was to use deep RNA sequencing to learn more about the mechanisms by which TIS108 and FL stimulate the germination of unconditioned P. aegyptiaca seeds. Deep RNA sequencing was performed to compare the mechanisms of germination in the following treatments: (i unconditioned P. aegyptiaca seeds with no other treatment, (ii unconditioned seeds treated with 100 mg/L TIS108, (iii unconditioned seeds treated with 100 mg/L FL + 100 mg/L GA3, (iv conditioned seeds treated with sterile water, and (v conditioned seeds treated with 0.03 mg/L GR24. The de novo assembled transcriptome was used to analyze transcriptional dynamics during seed germination. The key gene categories involved in germination were also identified. The results showed that only 119 differentially expressed genes were identified in the conditioned treatment vs TIS108 treatment. This indicated that the vast majority of conditions for germination were met during the conditioning stage. Abscisic acid (ABA and gibberellic acid (GA played important roles during P. aegyptiaca germination. The common pathway of TIS108, FL+GA3, and GR24 in stimulating P. aegyptiaca germination was the simultaneous reduction in ABA concentrations and increase GA concentrations. These results could potentially aid the identification of more compounds that are capable of stimulating P. aegyptiaca germination. Some potential target sites of TIS108 were also identified in

Transcriptome analysis of Phelipanche aegyptiaca seed germination mechanisms stimulated by fluridone, TIS108, and GR24.

Science.gov (United States)

Bao, Ya Zhou; Yao, Zhao Qun; Cao, Xiao Lei; Peng, Jin Feng; Xu, Ying; Chen, Mei Xiu; Zhao, Si Feng

2017-01-01

P. aegyptiaca is one of the most destructive root parasitic plants worldwide, causing serious damage to many crop species. Under natural conditions P. aegyptiaca seeds must be conditioned and then stimulated by host root exudates before germinating. However, preliminary experiments indicated that TIS108 (a triazole-type inhibitor of strigolactone) and fluridone (FL, an inhibitor of carotenoid-biosynthesis) both stimulated the germination of P. aegyptiaca seeds without a water preconditioning step (i.e. unconditioned seeds). The objective of this study was to use deep RNA sequencing to learn more about the mechanisms by which TIS108 and FL stimulate the germination of unconditioned P. aegyptiaca seeds. Deep RNA sequencing was performed to compare the mechanisms of germination in the following treatments: (i) unconditioned P. aegyptiaca seeds with no other treatment, (ii) unconditioned seeds treated with 100 mg/L TIS108, (iii) unconditioned seeds treated with 100 mg/L FL + 100 mg/L GA3, (iv) conditioned seeds treated with sterile water, and (v) conditioned seeds treated with 0.03 mg/L GR24. The de novo assembled transcriptome was used to analyze transcriptional dynamics during seed germination. The key gene categories involved in germination were also identified. The results showed that only 119 differentially expressed genes were identified in the conditioned treatment vs TIS108 treatment. This indicated that the vast majority of conditions for germination were met during the conditioning stage. Abscisic acid (ABA) and gibberellic acid (GA) played important roles during P. aegyptiaca germination. The common pathway of TIS108, FL+GA3, and GR24 in stimulating P. aegyptiaca germination was the simultaneous reduction in ABA concentrations and increase GA concentrations. These results could potentially aid the identification of more compounds that are capable of stimulating P. aegyptiaca germination. Some potential target sites of TIS108 were also identified in our

What is the comparative health status and associated risk factors for the Métis? A population-based study in Manitoba, Canada

Directory of Open Access Journals (Sweden)

Martens Patricia J

2011-10-01

Full Text Available Abstract Background Métis are descendants of early 17th century relationships between North American Indians and Europeans. This study's objectives were: (1 to compare the health status of the Métis people to all other residents of Manitoba, Canada; and (2 to analyze factors in predicting the likelihood of diabetes and related lower limb amputation. Methods Using de-identified administrative databases plus the Métis Population Database housed at the Manitoba Centre for Health Policy, age/sex-adjusted rates of mortality and disease were calculated for Métis (n = 73,016 and all other Manitobans (n = 1,104,672. Diseases included: hypertension, arthritis, diabetes, ischemic heart disease (age 19+; osteoporosis (age 50+; acute myocardial infarction (AMI and stroke (age 40+; total respiratory morbidity (TRM, all ages. Using logistic regression, predictors of diabetes (2004/05-2006/07 and diabetes-related lower-limb amputations (2002/03-2006/07 were analyzed. Results Disease rates were higher for Métis compared to all others: premature mortality before age 75 (4.0 vs. 3.3 per 1000, p Conclusion Despite universal healthcare, Métis' illness and mortality rates are mostly higher. Although elevated diabetes risk persists for the Métis even after adjusting for sociodemographic, healthcare and comorbidity variables, the risk of amputation for Métis appears more related to healthcare access rather than ethnicity.

Safety campaigns. TIS Launches New Safety Information Campaign

CERN Multimedia

2001-01-01

Need to start a new installation and worried about safety aspects? Or are you newly responsible for safety matters in a CERN building? Perhaps you're simply interested in how to make the working environment safer for yourself and your colleagues. Whatever the case, a new information campaign launched by TIS this week can help. The most visible aspects of the new campaign will be posters distributed around the Laboratory treating a different subject each month. The Web site - http://safety.cern.ch/ - which provides all safety related information. But these are not the only aspects of the new campaign. Members of the TIS/GS group, whose contact details can be found on the safety web site, are available to give information and advice on a one-to-one basis at any time. The campaign's launch has been timed to coincide with European Safety Week, organized by the European Agency for Safety and Health at Work and the subject treated in the first posters is safety inspection. This particular topic only concerns thos...

Electronic and Optical Properties of TiS_2 Determined from Generalized Gradient Approximation Study

International Nuclear Information System (INIS)

El-Kouch, Hamza; Farh, Larbi El; Sayah, Jamal; Challioui, Allal

2015-01-01

The electronic and optical properties of TiS_2 are studied by using an ab-initio calculation within the frame of density functional theory. A linearized and augmented plane wave basis set with the generalized gradient approximation as proposed by Perdew et al. is used for the energy exchange-correlation determination. The results show a metallic character of TiS_2, and the plots of total and partial densities of states of TiS_2 show the metallic character of the bonds and a strong hybridization between the states d of Ti and p of S below the Fermi energy. The optical properties of the material such as real and imaginary parts of dielectric constant (ϵ(ω) = ϵ_1(ω) + iϵ_2(ω)), refractive index n(ω), optical reflectivity R(ω), for E//x and E//z are performed for the energy range of 0–14 eV. (paper)

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

Science.gov (United States)

Xie, W; Fletcher, B S; Andersen, R D; Herschman, H R

1994-10-01

We recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factors and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5' of the TIS10/PGS2 transcription start site that mediates pp60v-src induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E-box (CACGTG) sequences. Gel shift-oligonucleotide competition experiments with nuclear extracts from cells stably transfected with a temperature-sensitive v-src gene demonstrate that the CGTCACGTG sequence can bind proteins at both the ATF/CRE and E-box sequences. Dominant-negative CREB and Myc proteins that bind DNA, but do not transactivate, block v-src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10/PGS2 promoter. Mutational analysis distinguishes which TIS10/PGS2 cis-acting element mediates pp60v-src induction. E-box mutation has no effect on the fold induction in response to pp60v-src. In contrast, ATF/CRE mutation attenuates the pp60v-src response. Antibody supershift and methylation interference experiments demonstrate that CREB and at least one other ATF transcription factor in these extracts bind to the TIS10/PGS2 ATF/CRE element. Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src. Our data suggest that Ras mediates pp60v-src activation of an ATF transcription factor, leading to induced TIS10/PGS2 expression via the ATF/CRE element of the TIS10/PGS2 promoter. This is the first description of v-src activation of gene expression via an ATF/CRE element.

TIS General Safety Group Annual Report 2000

CERN Document Server

Weingarten, W

2001-01-01

This report summarises the main activities of the General Safety (GS) Group of the Technical Inspection and Safety Division (TIS) during the year 2000, and the results obtained. The different topics in which the Group is active are covered: general safety inspections and ergonomy, electrical, chemistry and gas safety, chemical pollution containment and control, industrial hygiene, the safety of civil engineering works and outside contractors, fire prevention and the safety aspects of the LHC experiments.

FUNCTIONAL GENOMICS IDENTIFIES TIS21-DEPENDENT MECHANISMS AND PUTATIVE CANCER DRUG TARGETS UNDERLYING MEDULLOBLASTOMA SHH-TYPE DEVELOPMENT

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Giulia Gentile

2016-11-01

Full Text Available We have recently generated a novel medulloblastoma (MB mouse model with activation of the Shh pathway and lacking the MB suppressor Tis21 (Patched1+-Tis21KO.ts main phenotype is a defect of migration of the cerebellar granule precursor cells (GCPs. By genomic analysis of GCPs in vivo, we identified as drug target and major responsible of this defect the down-regulation of the promigratory chemokine Cxcl3. Consequently, the GCPs remain longer in the cerebellum proliferative area, and the MB frequency is enhanced. Here, we further analyzed the genes deregulated in a Tis21-dependent manner (Patched1+-is21 wild-type versus Ptch1+-Tis21 knockout, among which are a number of down-regulated tumor inhibitors and up-regulated tumor facilitators, focusing on pathways potentially involved in the tumorigenesis and on putative new drug targets.The data analysis using bioinformatic tools revealed: i a link between the Shh signaling and the Tis21-dependent impairment of the GCPs migration, through a Shh-dependent deregulation of the clathrin-mediated chemotaxis operating in the primary cilium through the Cxcl3-Cxcr2 axis; ii a possible lineage shift of Shh-type GCPs toward retinal precursor phenotype the neural cell type involved in group 3 MB; iii the identification of a subset of putative drug targets for MB, involved, among the others, in the regulation of Hippo signaling and centrosome assembly. Finally, our findings define also the role of Tis21 in the regulation of gene expression, through epigenetic and RNA processing mechanisms, influencing the fate of the GCPs.

Effect of ion irradiation on nanoscale TiS2 systems with suppressed Titania phase

International Nuclear Information System (INIS)

Hazarika, Saurabh J; Mohanta, Dambarudhar; Tripathi, A; Kanjilal, D.

2016-01-01

Titanium disulfide (TiS 2 ), being an important of the transition metal dichalcogenide, (TMDC) family, has drawn numerous interest owing to exhibition of tunable band gap as well as high carrier mobility. In this work, we highlight preparation of TiS 2 nanopowder with minimal TiO 2 content and also demonstrate modified properties upon swift heavy ion irradiation on TiS 2 nanoparticles dispersed PVA films. Different properties of the irradiated samples have been characterized through diffraction, microscopic and spectroscopic techniques. As a result of irradiation, due to agglomeration of particles, the grain size is found to increase. We could also observe a red shift after irradiation with increasing fluence, leading to easy flow of electron from valence to conduction band, which shows that conduction of electrons is more in case of irradiated films compared to the pristine one and thus there may be a possibility of using the irradiated samples in various optoelectronic devices. (paper)

v-src Induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element

Energy Technology Data Exchange (ETDEWEB)

Xie, W.; Fletcher, B.S.; Andersen, R.D.; Herschman, H.R. [Univ. of California, Los Angeles, CA (United States)

1994-10-01

The authors recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factor and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5{prime} of the TIS10/PGS2 transcription start site that mediates pp60{sup v-src} induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E-box (CACGTG) sequences. Gel shift-oligonucleotide competition experiments with nuclear extracts from cells stably transfected with a temperature-sensitive v-src gene demonstrate that the CGTCACGTG sequence can bind proteins at both the AFT/CRE and E-box sequences. Dominant-negative CREB and Myc proteins that bind DNA, but do not transactivate, block v-src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10/PGS2 promoter. Mutational analysis distinguishes which TIS10/PGS2 cis-acting element mediates pp60{sup v-src} induction. E-box mutation has no effect on the fold induction in response to pp60{sup v-src}. In contrast, ATF/CRE mutation attenuates the pp{sup v-src} response. Antibody supershift and methylation interference experiments demonstrate that CREB and at least one other ATF transcription factor in these extracts bind to the TIS10/PGS2 ATF/CRE element. Expression of a dominant-negative ras gene also blocks TIS10/PGS2 induction by v-src. The data suggest that Ras mediates pp60{sup v-src} activation of an ATF transcription factor, leading to induced TIS10/PGS2 expression via the ATF/CRE element of the TIS10/PGS2 promoter. This is the first description of v-src activation of gene expression via an ATF/CRE element. 64 refs., 8 figs.

La uveítis, comportamiento clínico epidemiológico en Pinar del Río

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Barbara Taysel Naranjo Valladares

2015-04-01

Full Text Available Introducción: la uveítis es la forma principal de inflamación ocular y puede estar asociada a diferentes etiologías. Constituyen una causa de deterioro visual y de ceguera. Objetivos: determinar el comportamiento clínico-epidemiológico de la uveítis en Pinar del Río. Material y método: se realizó una investigación longitudinal, prospectiva, aplicada y descriptiva en los pacientes, que acudieron a consulta de Uveítis del Hospital General Abel Santamaría Cuadrado, de la Provincia Pinar del Río, durante el período de abril-septiembre de 2014. El universo estuvo constituido por la totalidad de pacientes que acudieron a consulta, a los que se les diagnóstico uveítis (58, coincidiendo esta con la muestra. Para el análisis y elaboración de los datos obtenidos, se resumieron en cuadros estadísticos. El procesamiento estadístico fue mediante técnicas de estadística descriptiva, utilizando el sistema Epi Info y los resultados se muestran en tablas y figuras, utilizando el método porcentual. Resultados: predominaron los pacientes en las edades comprendidas entre los 31 y 50 años de edad, con ligero predominio del sexo masculino, color de la piel blanca, en la población rural. Fue más frecuente la uveítis anterior, de forma aguda, con resolución del cuadro en menos de 3 meses. Predominó la forma no granulomatosa, unilateral, idiopática. Las principales complicaciones asociadas al proceso inflamatorio fueron: la hipertensión ocular y las sinequias posteriores. Conclusiones: valorar adecuadamente las manifestaciones clínicas y complicaciones que acompañan la uveítis permiten realizar un diagnóstico y tratamiento correcto de esta peculiar enfermedad ocular.

Telephone Interpreter Services (TIS)-Asian and Pacific Islander (API) Language Yearly Dataset

Data.gov (United States)

Social Security Administration — This dataset displays our national TIS call volume for over 45 API languages for fiscal year 2011 onward. A fiscal year runs from October through September. We will...

Inimlik eksitus Lätis saatis kontrolli kõik Aura mahlajoogid / Hindrek Riikoja

Index Scriptorium Estoniae

Riikoja, Hindrek

2006-01-01

Tartu Õlletehase liiga suure säilitusaine sisalduse tõttu Lätis müügilt kõrvaldatud Aura Arcticu mahlajoogid tõid kaasa kogu tootesarja ulatusliku kontrolli. Rohkem eksimusi uuring ei tuvastanud. Lisa: Bensoehape

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

OpenAIRE

Xie, W; Fletcher, B S; Andersen, R D; Herschman, H R

1994-01-01

We recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factors and tumor promoters, the v-src oncogene induces TIS10/PGS2 expression in 3T3 cells. Deletion analysis, using luciferase reporters, identifies a region between -80 and -40 nucleotides 5' of the TIS10/PGS2 transcription start site that mediates pp60v-src induction in 3T3 cells. This region contains the sequence CGTCACGTG, which includes overlapping ATF/CRE (CGTCA) and E...

Chemical Welding on Semimetallic TiS2 Nanosheets for High-Performance Flexible n-Type Thermoelectric Films.

Science.gov (United States)

Zhou, Yuan; Wan, Juanyong; Li, Qi; Chen, Lei; Zhou, Jiyang; Wang, Heao; He, Dunren; Li, Xiaorui; Yang, Yaocheng; Huang, Huihui

2017-12-13

Solution-based processing of two-dimensional (2D) materials provides the possibility of allowing these materials to be incorporated into large-area thin films, which can translate the interesting fundamental properties of 2D materials into available devices. Here, we report for the first time a novel chemical-welding method to achieve high-performance flexible n-type thermoelectric films using 2D semimetallic TiS 2 nanosheets. We employ chemically exfoliated TiS 2 nanosheets bridged with multivalent cationic metal Al 3+ to cross-link the nearby sheets during the film deposition process. We find that such a treatment can greatly enhance the stability of the film and can improve the power factor by simultaneously increasing the Seebeck coefficient and electrical conductivity. The resulting TiS 2 nanosheet-based flexible film shows a room temperature power factor of ∼216.7 μW m -1 K -2 , which is among the highest chemically exfoliated 2D transition-metal dichalcogenide nanosheet-based films and comparable to the best flexible n-type thermoelectric films, to our knowledge, indicating its potential applications in wearable electronics.

Telephone Interpreter Services (TIS) - Asian and Pacific Islander (API) Language Fiscal Year Quarterly Dataset

Data.gov (United States)

Social Security Administration — This dataset displays our quarterly national TIS call volume for over 45 API languages for fiscal year 2013 onward. A fiscal year runs from October through September...

Study protocol for a pragmatic randomised controlled trial evaluating efficacy of a smoking cessation e-'Tabac Info Service': ee-TIS trial.

Science.gov (United States)

Cambon, L; Bergman, P; Le Faou, Al; Vincent, I; Le Maitre, B; Pasquereau, A; Arwidson, P; Thomas, D; Alla, F

2017-02-24

A French national smoking cessation service, Tabac Info Service, has been developed to provide an adapted quitline and a web and mobile application involving personalised contacts (eg, questionnaires, advice, activities, messages) to support smoking cessation. This paper presents the study protocol of the evaluation of the application (e-intervention Tabac Info Service (e-TIS)). The primary objective is to assess the efficacy of e-TIS. The secondary objectives are to (1) describe efficacy variations with regard to users' characteristics, (2) analyse mechanisms and contextual conditions of e-TIS efficacy. The study design is a two-arm pragmatic randomised controlled trial including a process evaluation with at least 3000 participants randomised to the intervention or to the control arm (current practices). Inclusion criteria are: aged 18 years or over, current smoker, having completed the online consent forms, possessing a mobile phone with android or apple systems and using mobile applications, wanting to stop smoking sooner or later. The primary outcome is the point prevalence abstinence of 7 days at 6 months later. Data will be analysed in intention to treat (primary) and per protocol analyses. A logistic regression will be carried out to estimate an OR (95% CI) for efficacy. A multivariate multilevel analysis will explore the influence on results of patients' characteristics (sex, age, education and socioprofessional levels, dependency, motivation, quit experiences) and contextual factors, conditions of use, behaviour change techniques. The study protocol was reviewed by the ethical and deontological institutional review board of the French Institute for Public Health Surveillance on 18 April 2016. The findings of this study will allow us to characterise the efficacy of e-TIS and conditions of its efficacy. These findings will be disseminated through peer-reviewed articles. NCT02841683; Pre-results. Published by the BMJ Publishing Group Limited. For

A Manual Transportable Instrument Platform for Ground-Based Spectro-Directional Observations (ManTIS and the Resultant Hyperspectral Field Goniometer System

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Marcel Buchhorn

2013-11-01

Full Text Available This article presents and technically describes a new field spectro-goniometer system for the ground-based characterization of the surface reflectance anisotropy under natural illumination conditions developed at the Alfred Wegener Institute (AWI. The spectro-goniometer consists of a Manual Transportable Instrument platform for ground-based Spectro-directional observations (ManTIS, and a hyperspectral sensor system. The presented measurement strategy shows that the AWI ManTIS field spectro-goniometer can deliver high quality hemispherical conical reflectance factor (HCRF measurements with a pointing accuracy of ±6 cm within the constant observation center. The sampling of a ManTIS hemisphere (up to 30° viewing zenith, 360° viewing azimuth needs approx. 18 min. The developed data processing chain in combination with the software used for the semi-automatic control provides a reliable method to reduce temporal effects during the measurements. The presented visualization and analysis approaches of the HCRF data of an Arctic low growing vegetation showcase prove the high quality of spectro-goniometer measurements. The patented low-cost and lightweight ManTIS instrument platform can be customized for various research needs and is available for purchase.

Accumulation of cytolytic CD8{sup +} T cells in B16-melanoma and proliferation of mature T cells in TIS21-knockout mice after T cell receptor stimulation

Energy Technology Data Exchange (ETDEWEB)

Ryu, Min Sook [Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, 164, World cul-ro, Yeongtong-gu, Suwon, Gyeonggi-do 443-380 (Korea, Republic of); Woo, Min-Yeong [Department of Microbiology, Ajou University School of Medicine, 164, World cul-ro, Yeongtong-gu, Suwon, Gyeonggi-do 443-380 (Korea, Republic of); Department of Biomedical Sciences, The Graduate School, Ajou University (Korea, Republic of); Kwon, Daeho [Department of Microbiology, Kwandong University College of Medicine, Gangneung, Gangwon-do 210-701 (Korea, Republic of); Hong, Allen E. [Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, 164, World cul-ro, Yeongtong-gu, Suwon, Gyeonggi-do 443-380 (Korea, Republic of); Song, Kye Yong [Department of Pathology, Chung-Ang University College of Medicine, Dongjak-gu, Seoul 156-756 (Korea, Republic of); Park, Sun [Department of Microbiology, Ajou University School of Medicine, 164, World cul-ro, Yeongtong-gu, Suwon, Gyeonggi-do 443-380 (Korea, Republic of); Lim, In Kyoung [Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, 164, World cul-ro, Yeongtong-gu, Suwon, Gyeonggi-do 443-380 (Korea, Republic of)

2014-10-01

In vivo and in vitro effects of TIS21 gene on the mature T cell activation and antitumor activities were explored by employing MO5 melanoma orthograft and splenocytes isolated from the TIS21-knockout (KO) mice. Proliferation and survival of mature T cells were significantly increased in the KO than the wild type (WT) cells, indicating that TIS21 inhibits the rate of mature T cell proliferation and its survival. In MO5 melanoma orthograft model, the KO mice recruited much more CD8{sup +} T cells into the tumors at around day 14 after tumor cell injection along with reduced tumor volumes compared with the WT. The increased frequency of granzyme B{sup +} CD8{sup +} T cells in splenocytes of the KO mice compared with the WT may account for antitumor-immunity of TIS21 gene in the melanoma orthograft. In contrast, reduced frequencies of CD107a{sup +} CD8{sup +} T cells in the splenocytes of KO mice may affect the loss of CD8{sup +} T cell infiltration in the orthograft at around day 19. These results indicate that TIS21 exhibits antiproliferative and proapoptotic effects in mature T cells, and differentially affects the frequencies of granzyme B{sup +} CD8{sup +} T-cells and CD107a{sup +} CD8{sup +} T-cells, thus transiently regulating in vivo anti-tumor immunity. - Highlights: • Constitutive expression of TIS21 in splenocytes and upregulation by TCR stimulation. • Proliferation of mature T-cells in spleen of TIS21KO mice after TCR stimulation. • Inhibition of cell death in mature T-cells of TIS21KO mice compared with the wild type. • Inhibition of melanoma growth in TIS21KO mice and CD8{sup +} T cell infiltration in tumor. • Reduction of CD 107{sup +}CD8{sup +} T cells, but increased granzyme B{sup +} CD8{sup +} T cells in TIS21KO mice.

Sustainable Multi-Product Seafood Production Planning Under Uncertainty

International Nuclear Information System (INIS)

Simanjuntak, Ruth; Mawengkang, Herman; Sembiring, Monalisa; Sinaga, Rani; Pakpahan, Endang J

2013-01-01

A multi-product fish production planning produces simultaneously multi fish products from several classes of raw resources. The goal in sustainable production planning is to meet customer demand over a fixed time horizon divided into planning periods by optimizing the tradeoff between economic objectives such as production cost, waste processed cost, and customer satisfaction level. The major decisions are production and inventory levels for each product and the number of workforce in each planning period. In this paper we consider the management of small scale traditional business at North Sumatera Province which performs processing fish into several local seafood products. The inherent uncertainty of data (e.g. demand, fish availability), together with the sequential evolution of data over time leads the sustainable production planning problem to a nonlinear mixed-integer stochastic programming model. We use scenario generation based approach and feasible neighborhood search for solving the model.

Health professionals working with First Nations, Inuit, and Métis consensus guideline.

Science.gov (United States)

Wilson, Don; de la Ronde, Sandra; Brascoupé, Simon; Apale, Alisha Nicole; Barney, Lucy; Guthrie, Bing; Harrold, Elizabeth; Horn, Ojistoh; Johnson, Robin; Rattray, Darrien; Robinson, Nicole; Alainga-Kango, Natsiq; Becker, Gisela; Senikas, Vyta; Aningmiuq, Annie; Bailey, Geri; Birch, Darlene; Cook, Katsi; Danforth, Jessica; Daoust, Mary; Kitty, Darlene; Koebel, Jaime; Kornelsen, Judith; Tsatsa Kotwas, Ndakaitedzva; Lawrence, Audrey; Mudry, Amanda; Senikas, Vyta; Turner, Gail Theresa; Van Wagner, Vicki; Vides, Eduardo; Wasekeesikaw, Fjola Hart; Wolfe, Sara

2013-06-01

Our aim is to provide health care professionals in Canada with the knowledge and tools to provide culturally safe care to First Nations, Inuit, and Métis women and through them, to their families, in order to improve the health of First Nations, Inuit, and Métis. Published literature was retrieved through searches of PubMed, CINAHL, Sociological Abstracts, and The Cochrane Library in 2011 using appropriate controlled vocabulary (e.g.,cultural competency, health services, indigenous, transcultural nursing) and key words (e.g., indigenous health services, transcultural health care, cultural safety). Targeted searches on subtopics (e.g., ceremonial rites and sexual coming of age) were also performed. The PubMed search was restricted to the years 2005 and later because of the large number of records retrieved on this topic. Searches were updated on a regular basis and incorporated in the guideline to May 2012. Grey (unpublished) literature was identified through searching the websites of selected related agencies (e.g., Campbell Collaboration, Social Care Online, Institute for Healthcare Improvement). The quality of evidence in this document was rated using the criteria described in the Report of the Canadian Task force on Preventive Health Care (Table).

Design of a sentence identification test with pictures (TIS-F based on the pediatric speech intelligibility test

Directory of Open Access Journals (Sweden)

Fernanda Freitas Vellozo

Full Text Available ABSTRACT Purposes: to design a sentence identification test with pictures for adults (Teste de Identificação de Sentenças com Figuras (TIS-F as an alternative for evaluation of auditory figure-background ability for verbal sounds, based on the Pediatric Speech Intelligibility Test and also for assessment of unskillful individuals who cannot accomplish other tests with higher levels of difficulty and greater demands. Methods: the Adobe Illustrator software was used and the image vectorization technique applied for figures creation. The sentences and the competitive message were audio-recorded in a sound treated room by a female announcer, using the software - REAPER - FM Digital Audio Workstation. Results: the TIS-F consisted of a 32 x 45 cm card, containing 10 figures, each one measuring 12 x 12 cm; one compact disc containing a track with the test calibration tone and seven test tracks, each one containing ten sentences and a competitive message and a specific protocol. Conclusion: the TIS-F is composed of a compact disc with dual-channel recording, with seven tracks containing ten sentences and the competitive story, one card containing ten pictures and a labeling protocol for all presentations and S/N in use, as well as the established normality values.

Chronic disease and chronic disease risk factors among First Nations, Inuit and Métis populations of northern Canada.

Science.gov (United States)

Bruce, S G; Riediger, N D; Lix, L M

2014-11-01

Aboriginal populations in northern Canada are experiencing rapid changes in their environments, which may negatively impact on health status. The purpose of our study was to compare chronic conditions and risk factors in northern Aboriginal populations, including First Nations (FN), Inuit and Métis populations, and northern non-Aboriginal populations. Data were from the Canadian Community Health Survey for the period from 2005 to 2008. Weighted multiple logistic regression models tested the association between ethnic groups and health outcomes. Model covariates were age, sex, territory of residence, education and income. Odds ratios (ORs) are reported and a bootstrap method calculated 95% confidence intervals (CIs) and p values. Odds of having at least one chronic condition was significantly lower for the Inuit (OR = 0.59; 95% CI: 0.43-0.81) than for non-Aboriginal population, but similar among FN, Métis and non-Aboriginal populations. Prevalence of many risk factors was significantly different for Inuit, FN and Métis populations. Aboriginal populations in Canada's north have heterogeneous health status. Continued chronic disease and risk factor surveillance will be important to monitor changes over time and to evaluate the impact of public health interventions.

Ab initio computation of the transition temperature of the charge density wave transition in TiS e2

Science.gov (United States)

Duong, Dinh Loc; Burghard, Marko; Schön, J. Christian

2015-12-01

We present a density functional perturbation theory approach to estimate the transition temperature of the charge density wave transition of TiS e2 . The softening of the phonon mode at the L point where in TiS e2 a giant Kohn anomaly occurs, and the energy difference between the normal and distorted phase are analyzed. Both features are studied as functions of the electronic temperature, which corresponds to the Fermi-Dirac distribution smearing value in the calculation. The transition temperature is found to be 500 and 600 K by phonon and energy analysis, respectively, in reasonable agreement with the experimental value of 200 K.

Policy silences: why Canada needs a National First Nations, Inuit and Métis health policy.

Science.gov (United States)

Lavoie, Josée G

2013-12-27

Despite attempts, policy silences continue to create barriers to addressing the healthcare needs of First Nations, Inuit and Métis. The purpose of this article is to answer the question, if what we have in Canada is an Aboriginal health policy patchwork that fails to address inequities, then what would a Healthy Aboriginal Health Policy framework look like? The data collected included federal, provincial and territorial health policies and legislation that contain Aboriginal, First Nation, Inuit and/or Métis-specific provisions available on the internet. Key websites included the Parliamentary Library, federal, provincial and territorial health and Aboriginal websites, as well as the Department of Justice Canada, Statistics Canada and the Aboriginal Canada Portal. The Indian Act gives the Governor in Council the authority to make health regulations. The First Nations and Inuit Health Branch (FNIHB) of Health Canada historically provided health services to First Nations and Inuit, as a matter of policy. FNIHB's policies are few, and apply only to Status Indians and Inuit. Health legislation in 2 territories and 4 provinces contain no provision to clarify their responsibilities. In provinces where provisions exist, they broadly focus on jurisdiction. Few Aboriginal-specific policies and policy frameworks exist. Generally, these apply to some Aboriginal peoples and exclude others. Although some Aboriginal-specific provisions exist in some legislation, and some policies are in place, significant gaps and jurisdictional ambiguities remain. This policy patchwork perpetuates confusion. A national First Nation, Inuit and Métis policy framework is needed to address this issue.

Tracking sentence planning and production.

Science.gov (United States)

Kemper, Susan; Bontempo, Daniel; McKedy, Whitney; Schmalzried, RaLynn; Tagliaferri, Bruno; Kieweg, Doug

2011-03-01

To assess age differences in the costs of language planning and production. A controlled sentence production task was combined with digital pursuit rotor tracking. Participants were asked to track a moving target while formulating a sentence using specified nouns and verbs and to continue to track the moving target while producing their response. The length of the critical noun phrase (NP) as well as the type of verb provided were manipulated. The analysis indicated that sentence planning was more costly than sentence production, and sentence planning costs increased when participants had to incorporate a long NP into their sentence. The long NPs also tended to be shifted to the end of the sentence, whereas short NPs tended to be positioned after the verb. Planning or producing responses with long NPs was especially difficult for older adults, although verb type and NP shift had similar costs for young and older adults. Pursuit rotor tracking during controlled sentence production reveals the effects of aging on sentence planning and production.

Effect of immersion time on in vitro multiplication of Bambusa vulgaris Schrader ex Wendland in RITA® TIS

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Mallelyn González González

2013-01-01

Full Text Available The TIS provides solutions to the constraints that affecting in vitro propagation of bamboos and increases the quality of the plants in vitro propagated and survival of these in greenhouse conditions and field. This study aimed to determine the effect of immersion time on the multiplication of B. vulgaris shoot grown in TIS (RITA. Morphological, physiological and biochemical variables such as the number of shoots per plant, length of shoots, number of leaves per shoot, water contents, and lignin phenols were analyzed. It was demonstrated that the immersion time influenced the in vitro multiplication of B. vulgaris. The explants treated with the immersion time of a minute developed a greater number of shoots (5. These shoots showed dark green coloration, 92.1% water and 13% lignin. However, the increase of immersion time to three minutes caused increase in the water content of shoots and decreased lignin content, which affected their morphological response and multiplication in the TIS (RITA. Analysis of morphological, physiological and biochemical variables, allowed defining one minute is the optimum immersion time for shoot multiplication of B. vulgaris in temporary immersion systems (RITA. The method of in vitro propagation of B. vulgaris described offers the advantage of using liquid culture media and automated systems. Key words: bamboo, in vitro multiplication, morphological variables, temporal immersion systems

Hierarchical production planning for consumer goods

NARCIS (Netherlands)

Kok, de A.G.

1990-01-01

Abstract In this paper the mathematical logic behind a hierarchical planning procedure is discussed. The planning procedure is used to derive production volumes of consumer products. The essence of the planning procedure is that first a commitment is made concerning the production volume for a

Características clínicas y diagnóstico etiológico de las uveítis virales

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Adrianne Mayuli Suñet Álvarez

Full Text Available Objetivo: determinar las características clínicas y epidemiológicas de las uveítis virales según su etiología. Métodos: se realizó un estudio observacional y descriptivo transversal, que determinó el diagnóstico clínico y etiológico, según la reacción en cadena de polimerasa (PCR de 10 ojos de pacientes atendidos en la consulta de uveítis, en el Instituto Cubano de Oftalmología «Ramón Pando Ferrer», de mayo a noviembre del 2010. Se utilizó una muestra de fluidos intraoculares tomada a los pacientes. Las variables analizadas fueron: edad, sexo, color de piel, antecedentes personales generales u oculares, clasificación anatómica y patológica de la uveítis, curso evolutivo, bilateralidad, agudeza visual y presión intraocular iniciales y finales respectivamente, hallazgos al fondo de ojo y resultados de la PCR. La información fue procesada y los resultados expuestos en tablas. Resultados: la edad promedio de los pacientes estudiados fue de 34,5 años, que presentaron en su mayoría episodios de uveítis anteriores unilaterales. La agudeza visual mejor corregida final mejoró con respecto a la inicial en el grupo de estudio, aunque la presión intraocular se mantuvo elevada sin lograr controlarla. El virus más hallado fue el Herpes simple. Conclusiones: los virus son responsables de producir inflamaciones oculares de presentación variada, lo que en ocasiones retrasa el diagnóstico, empeorando el pronóstico visual. En estos casos el método de PCR ha demostrado ser una herramienta útil para establecer el diagnóstico etiológico.

Effectiveness of the CANRISK tool in the identification of dysglycemia in First Nations and Métis in Canada

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Gina Agarwal

2018-02-01

Full Text Available Introduction: First Nations/Métis populations develop diabetes earlier and at higher rates than other Canadians. The Canadian diabetes risk questionnaire (CANRISK was developed as a diabetes screening tool for Canadians aged 40 years or over. The primary aim of this paper is to assess the effectiveness of the existing CANRISK tool and risk scores in detecting dysglycemia in First Nations/Métis participants, including among those under the age of 40. A secondary aim was to determine whether alternative waist circumference (WC and body mass index (BMI cut-off points improved the predictive ability of logistic regression models using CANRISK variables to predict dysglycemia. Methods: Information from a self-administered CANRISK questionnaire, anthropometric measurements, and results of a standard oral glucose tolerance test (OGTT were collected from First Nations and Métis participants (n = 1479. Sensitivity and specificity of CANRISK scores using published risk score cut-off points were calculated. Logistic regression was conducted with alternative ethnicity-specific BMI and WC cut-off points to predict dysglycemia using CANRISK variables. Results: Compared with OGTT results, using a CANRISK score cut-off point of 33, the sensitivity and specificity of CANRISK was 68% and 63% among individuals aged 40 or over; it was 27% and 87%, respectively among those under 40. Using a lower cut-off point of 21, the sensitivity for individuals under 40 improved to 77% with a specificity of 44%. Though specificity at this threshold was low, the higher level of sensitivity reflects the importance of the identification of high risk individuals in this population. Despite altered cut-off points of BMI and WC, logistic regression models demonstrated similar predictive ability. Conclusion: CANRISK functioned well as a preliminary step for diabetes screening in a broad age range of First Nations and Métis in Canada, with an adjusted CANRISK cutoff point for

Effectiveness of the CANRISK tool in the identification of dysglycemia in First Nations and Métis in Canada

Science.gov (United States)

Gina, Agarwal; Ying, Jiang; Susan, Rogers Van Katwyk; Chantal, Lemieux; Heather, Orpana; Yang, Mao; Brandan, Hanley; Karen, Davis; Laurel, Leuschen; Howard, Morrison

2018-01-01

Abstract Introduction: First Nations/Métis populations develop diabetes earlier and at higher rates than other Canadians. The Canadian diabetes risk questionnaire (CANRISK) was developed as a diabetes screening tool for Canadians aged 40 years or over. The primary aim of this paper is to assess the effectiveness of the existing CANRISK tool and risk scores in detecting dysglycemia in First Nations/Métis participants, including among those under the age of 40. A secondary aim was to determine whether alternative waist circumference (WC) and body mass index (BMI) cut-off points improved the predictive ability of logistic regression models using CANRISK variables to predict dysglycemia. Methods: Information from a self-administered CANRISK questionnaire, anthropometric measurements, and results of a standard oral glucose tolerance test (OGTT) were collected from First Nations and Métis participants (n = 1479). Sensitivity and specificity of CANRISK scores using published risk score cut-off points were calculated. Logistic regression was conducted with alternative ethnicity-specific BMI and WC cut-off points to predict dysglycemia using CANRISK variables. Results: Compared with OGTT results, using a CANRISK score cut-off point of 33, the sensitivity and specificity of CANRISK was 68% and 63% among individuals aged 40 or over; it was 27% and 87%, respectively among those under 40. Using a lower cut-off point of 21, the sensitivity for individuals under 40 improved to 77% with a specificity of 44%. Though specificity at this threshold was low, the higher level of sensitivity reflects the importance of the identification of high risk individuals in this population. Despite altered cut-off points of BMI and WC, logistic regression models demonstrated similar predictive ability. Conclusion: CANRISK functioned well as a preliminary step for diabetes screening in a broad age range of First Nations and Métis in Canada, with an adjusted CANRISK cutoff point for individuals

AVLIS Production Plant Project Management Plan

International Nuclear Information System (INIS)

1984-01-01

The AVLIS Production Plant is designated as a Major System Acquisition (in accordance with DOE Order 4240.IC) to deploy Atomic Vapor Laser Isotope Separation (AVLIS) technology at the Oak Ridge, Tennessee site, in support of the US Uranium Enrichment Program. The AVLIS Production Plant Project will deploy AVLIS technology by performing the design, construction, and startup of a production plant that will meet capacity production requirements of the Uranium Enrichment Program. The AVLIS Production Plant Project Management Plan has been developed to outline plans, baselines, and control systems to be employed in managing the AVLIS Production Plant Project and to define the roles and responsibilities of project participants. Participants will develop and maintain detailed procedures for implementing the management and control systems in agreement with this plan. This baseline document defines the system that measures work performed and costs incurred. This plan was developed by the AVLIS Production Plant Project staff of Martin Marietta Energy Systems, Inc. and Lawrence Livermore National Laboratory in accordance with applicable DOE directives, orders and notices. 38 figures, 19 tables

Dynamic Domains in Data Production Planning

Science.gov (United States)

Golden, Keith; Pang, Wanlin

2005-01-01

This paper discusses a planner-based approach to automating data production tasks, such as producing fire forecasts from satellite imagery and weather station data. Since the set of available data products is large, dynamic and mostly unknown, planning techniques developed for closed worlds are unsuitable. We discuss a number of techniques we have developed to cope with data production domains, including a novel constraint propagation algorithm based on planning graphs and a constraint-based approach to interleaved planning, sensing and execution.

Factors Associated With Current Smoking Among Off-Reserve First Nations and Métis Youth: Results From the 2012 Aboriginal Peoples Survey.

Science.gov (United States)

Ryan, Christopher; Leatherdale, Scott; Cooke, Martin

2017-04-01

First Nations and Métis, two of Canada's constitutionally recognized Indigenous groups, suffer from poorer overall health than non-Indigenous Canadians. Current smoking, a known predictor of chronic health conditions, is close to twice as prevalent among Indigenous youth as it is among non-Indigenous Canadian youth. However, little population-level research has examined the correlates of current smoking among this population. Guided by a health framework centered on Indigenous-specific determinants, we used data from the 2012 Aboriginal Peoples Survey to examine the correlates of current smoking among First Nations and Métis youth aged 15-17 years living outside of First Nations reserves. Using binary logistic regression, we investigated how culturally specific factors, namely knowledge of an Indigenous language, participation in traditional activities, and family members' attendance at residential schools, were correlated with current smoking. We also considered demographic, geographic, socioeconomic and health-related correlates. Overall, an estimated 20.6% of First Nations and Métis youth reported current smoking. We found no significant associations between culturally specific activities and current smoking in the multivariate analyses, although those who spoke an Indigenous language were more likely to smoke. Those who participated in sports more often were less likely to smoke, and respondents who reported heavy drinking and who were from families with lower income were more likely to smoke. Gender, body mass index, urban/rural geography and regional geography, and mother's highest level of education were not significantly correlated with smoking. The results of our study support prior research that has found a disturbingly high prevalence of current smoking among Indigenous youth, compared to their non-Indigenous counterparts. Our results highlight the importance of considering sports participation, co-occurring health-risk behaviours and socioeconomic

The volt-ampere characteristic and pole-Frenkel effect of TIS crystal

International Nuclear Information System (INIS)

Kahramanova, S.M.; Mammadova, G.E.; Abdullayeva, I.A.

2016-01-01

As known, some features were observed at the Volt-Ampere Character while current severity deviation from voltage and liner dependence, which means that all happen at Volt-Ampere Character of upper oblasts than ohmic oblast. At this time, in many cases electric properties can not be provide one conductivity mechanism in the powerful electric field and it is explained by different mechanisms at different quantity oblast of electric field intensity. It was determined that, current in the non-liner part of Volt-Ampere Character of the TIS crystal conditioned with weak field effect and is explained in the context of Pul-Frenkel thermal field theory.

Study protocol for a pragmatic randomised controlled trial evaluating efficacy of a smoking cessation e-‘Tabac Info Service’: ee-TIS trial

Science.gov (United States)

Cambon, L; Bergman, P; Le Faou, Al; Vincent, I; Le Maitre, B; Pasquereau, A; Arwidson, P; Thomas, D; Alla, F

2017-01-01

Introduction A French national smoking cessation service, Tabac Info Service, has been developed to provide an adapted quitline and a web and mobile application involving personalised contacts (eg, questionnaires, advice, activities, messages) to support smoking cessation. This paper presents the study protocol of the evaluation of the application (e-intervention Tabac Info Service (e-TIS)). The primary objective is to assess the efficacy of e-TIS. The secondary objectives are to (1) describe efficacy variations with regard to users' characteristics, (2) analyse mechanisms and contextual conditions of e-TIS efficacy. Methods and analyses The study design is a two-arm pragmatic randomised controlled trial including a process evaluation with at least 3000 participants randomised to the intervention or to the control arm (current practices). Inclusion criteria are: aged 18 years or over, current smoker, having completed the online consent forms, possessing a mobile phone with android or apple systems and using mobile applications, wanting to stop smoking sooner or later. The primary outcome is the point prevalence abstinence of 7 days at 6 months later. Data will be analysed in intention to treat (primary) and per protocol analyses. A logistic regression will be carried out to estimate an OR (95% CI) for efficacy. A multivariate multilevel analysis will explore the influence on results of patients' characteristics (sex, age, education and socioprofessional levels, dependency, motivation, quit experiences) and contextual factors, conditions of use, behaviour change techniques. Ethics and dissemination The study protocol was reviewed by the ethical and deontological institutional review board of the French Institute for Public Health Surveillance on 18 April 2016. The findings of this study will allow us to characterise the efficacy of e-TIS and conditions of its efficacy. These findings will be disseminated through peer-reviewed articles. Trial registration

High Frequency Jet Ventilation during Transoral Laser Microsurgery for Tis-T2 Laryngeal Cancer.

Science.gov (United States)

Mora, Francesco; Missale, Francesco; Incandela, Fabiola; Filauro, Marta; Parrinello, Giampiero; Paderno, Alberto; Della Casa, Palmiro; Piazza, Cesare; Peretti, Giorgio

2017-01-01

Transoral laser microsurgery (TLM) for early to intermediate laryngeal squamous cell cancer (SCC) can be technically challenging when adequate exposure of the posterior laryngeal compartment is required due to the presence of the orotracheal tube. The goal of our study was to analyze the efficacy of high frequency jet ventilation (HFJV) in achieving appropriate laryngeal exposure and safe oncologic resection of lesions located in such a position. We reviewed the clinical records of 62 patients affected by Tis-T2 SCC of the posterior laryngeal compartment treated by TLM between 02/2012 and 12/2016. The cohort was divided into two groups according to the anesthesiologic technique used: Group A included patients treated using intraoperative infraglottic HFJV, while Group B encompassed patients treated by standard orotracheal intubation. The main outcome was postoperative surgical margin status. Group comparison analysis was performed. Significant difference in deep margin status was observed between the two groups: in Group A, the rate of negative deep margins was 86% compared to 56% in Group B ( p  = 0.04). A trend of better overall and superficial margin control was observed for patients treated using HFJV (Group A), although no statistical significance was achieved. Use of HFJV during TLM allows easier and safer management of patients affected by Tis-T2 SCC of the posterior laryngeal compartment, reducing the rates of positive superficial and deep surgical margins.

Production planning in the Combinado Lácteo Santiago

Directory of Open Access Journals (Sweden)

Edith Carmen Fajardo-Alcolea

2017-12-01

Full Text Available A planning, programming and control of the production procedure is designed in this paper to consider all the technical and organizational aspects that are involved in planning, using the balance and normative method, and a variant of the General Algorithm for the Calculation of the Capacities. This procedure is supported by an innovative computer application designed to assist students, technicians and specialists in the planning stages. The procedure is applied in the company “Combinado Lácteo de Santiago de Cuba” to plan the production in 2016. As a result, an innovation of an organizational type is obtained that allows the Production Master Plan, disaggregated in the different time horizons, consider the real capacity of the plants. For its evaluation it was compared to the production plan prepared by the company and the actual production data of the first quarter of the year to determine the existing differences.

Planning product quality: An example - ornamental plants

Directory of Open Access Journals (Sweden)

Kovačević Miodrag

2003-01-01

Full Text Available The industry of ornamental plants is a subject of quality planning. The quality plan is a document setting out the specific quality practices in ornamental plants production. That plan introduce organizational structure procedures, processes and resources needed to implement quality in life cycle of product chain. For engineers it represents a new tool.

Applying linear programming model to aggregate production planning of coated peanut products

Science.gov (United States)

Rohmah, W. G.; Purwaningsih, I.; Santoso, EF S. M.

2018-03-01

The aim of this study was to set the overall production level for each grade of coated peanut product to meet market demands with a minimum production cost. The linear programming model was applied in this study. The proposed model was used to minimize the total production cost based on the limited demand of coated peanuts. The demand values applied to the method was previously forecasted using time series method and production capacity aimed to plan the aggregate production for the next 6 month period. The results indicated that the production planning using the proposed model has resulted a better fitted pattern to the customer demands compared to that of the company policy. The production capacity of product family A, B, and C was relatively stable for the first 3 months of the planning periods, then began to fluctuate over the next 3 months. While, the production capacity of product family D and E was fluctuated over the 6-month planning periods, with the values in the range of 10,864 - 32,580 kg and 255 – 5,069 kg, respectively. The total production cost for all products was 27.06% lower than the production cost calculated using the company’s policy-based method.

IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

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René Klega

2014-03-01

Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

High Frequency Jet Ventilation during Transoral Laser Microsurgery for Tis-T2 Laryngeal Cancer

Directory of Open Access Journals (Sweden)

Francesco Mora

2017-11-01

Full Text Available BackgroundTransoral laser microsurgery (TLM for early to intermediate laryngeal squamous cell cancer (SCC can be technically challenging when adequate exposure of the posterior laryngeal compartment is required due to the presence of the orotracheal tube. The goal of our study was to analyze the efficacy of high frequency jet ventilation (HFJV in achieving appropriate laryngeal exposure and safe oncologic resection of lesions located in such a position.MethodsWe reviewed the clinical records of 62 patients affected by Tis-T2 SCC of the posterior laryngeal compartment treated by TLM between 02/2012 and 12/2016. The cohort was divided into two groups according to the anesthesiologic technique used: Group A included patients treated using intraoperative infraglottic HFJV, while Group B encompassed patients treated by standard orotracheal intubation. The main outcome was postoperative surgical margin status. Group comparison analysis was performed.ResultsSignificant difference in deep margin status was observed between the two groups: in Group A, the rate of negative deep margins was 86% compared to 56% in Group B (p = 0.04. A trend of better overall and superficial margin control was observed for patients treated using HFJV (Group A, although no statistical significance was achieved.ConclusionUse of HFJV during TLM allows easier and safer management of patients affected by Tis-T2 SCC of the posterior laryngeal compartment, reducing the rates of positive superficial and deep surgical margins.

Robust Optimization Model for Production Planning Problem under Uncertainty

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Pembe GÜÇLÜ

2017-01-01

Full Text Available Conditions of businesses change very quickly. To take into account the uncertainty engendered by changes has become almost a rule while planning. Robust optimization techniques that are methods of handling uncertainty ensure to produce less sensitive results to changing conditions. Production planning, is to decide from which product, when and how much will be produced, with a most basic definition. Modeling and solution of the Production planning problems changes depending on structure of the production processes, parameters and variables. In this paper, it is aimed to generate and apply scenario based robust optimization model for capacitated two-stage multi-product production planning problem under parameter and demand uncertainty. With this purpose, production planning problem of a textile company that operate in İzmir has been modeled and solved, then deterministic scenarios’ and robust method’s results have been compared. Robust method has provided a production plan that has higher cost but, will result close to feasible and optimal for most of the different scenarios in the future.

Appendix E - Sample Production Facility Plan

Science.gov (United States)

This sample Spill Prevention, Control and Countermeasure (SPCC) Plan in Appendix E is intended to provide examples and illustrations of how a production facility could address a variety of scenarios in its SPCC Plan.

The Effect of Production Planning and Budgeting on Organizational Productivity

Directory of Open Access Journals (Sweden)

Patrick Adebisi Olusegun ADEGBUYI

2010-12-01

Full Text Available Improved productivity and proper organizational structure are desired by most manufacturing outfits within the highly turbulent business environment of Nigeria. With various contributing factors, scientific basis for decision making that will lead to enhanced policies for organizational operations is stronlgy established. Five statistical hypotheses which are influence of education, government policies, planning and organizational output, and production planning/budgeting and technological advancement, propounded in this work were investigated to establish a valid decision basis on a confidence level assumed to be 0.05. The work finally examined the impact of the hypotheses on productivity.

Integrated production planning and control: A multi-objective optimization model

Directory of Open Access Journals (Sweden)

Cheng Wang

2013-09-01

Full Text Available Purpose: Production planning and control has crucial impact on the production and business activities of enterprise. Enterprise Resource Planning (ERP is the most popular resources planning and management system, however there are some shortcomings and deficiencies in the production planning and control because its core component is still the Material Requirements Planning (MRP. For the defects of ERP system, many local improvement and optimization schemes have been proposed, and improve the feasibility and practicality of the plan in some extent, but study considering the whole planning system optimization in the multiple performance management objectives and achieving better application performance is less. The purpose of this paper is to propose a multi-objective production planning optimization model Based on the point of view of the integration of production planning and control, in order to achieve optimization and control of enterprise manufacturing management. Design/methodology/approach: On the analysis of ERP planning system’s defects and disadvantages, and related research and literature, a multi-objective production planning optimization model is proposed, in addition to net demand and capacity, multiple performance management objectives, such as on-time delivery, production balance, inventory, overtime production, are considered incorporating into the examination scope of the model, so that the manufacturing process could be management and controlled Optimally between multiple objectives. The validity and practicability of the model will be verified by the instance in the last part of the paper. Findings: The main finding is that production planning management of manufacturing enterprise considers not only the capacity and materials, but also a variety of performance management objectives in the production process, and building a multi-objective optimization model can effectively optimize the management and control of enterprise

Essential Oil Content of the Rhizome of Curcuma purpurascens Bl. (Temu Tis) and Its Antiproliferative Effect on Selected Human Carcinoma Cell Lines

Science.gov (United States)

Hong, Sok-Lai; Lee, Guan-Serm; Ahmed Hamdi, Omer Abdalla; Awang, Khalijah; Aznam Nugroho, Nurfina

2014-01-01

Curcuma purpurascens Bl., belonging to the Zingiberaceae family, is known as temu tis in Yogyakarta, Indonesia. In this study, the hydrodistilled dried ground rhizome oil was investigated for its chemical content and antiproliferative activity against selected human carcinoma cell lines (MCF7, Ca Ski, A549, HT29, and HCT116) and a normal human lung fibroblast cell line (MRC5). Results from GC-MS and GC-FID analysis of the rhizome oil of temu tis showed turmerone as the major component, followed by germacrone, ar-turmerone, germacrene-B, and curlone. The rhizome oil of temu tis exhibited strong cytotoxicity against HT29 cells (IC50 value of 4.9 ± 0.4 μg/mL), weak cytotoxicity against A549, Ca Ski, and HCT116 cells (with IC50 values of 46.3 ± 0.7, 32.5 ± 1.1, and 35.0 ± 0.3 μg/mL, resp.), and no inhibitory effect against MCF7 cells. It exhibited mild cytotoxicity against a noncancerous human lung fibroblast cell line (MRC5), with an IC50 value of 25.2 ± 2.7 μg/mL. This is the first report on the chemical composition of this rhizome's oil and its selective antiproliferative effect on HT29. The obtained data provided a basis for further investigation of the mode of cell death. PMID:25177723

AVLIS production plant waste management plan

International Nuclear Information System (INIS)

1984-01-01

Following the executive summary, this document contains the following: (1) waste management facilities design objectives; (2) AVLIS production plant wastes; (3) waste management design criteria; (4) waste management plan description; and (5) waste management plan implementation. 17 figures, 18 tables

Uudised : EMA uus barokkorel. Olari Elts Soome Raadio SO ees. "Supreme Silence" Saksamaal. Kangro muusika Lätis ja Leedus / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

EMA vastvalminud barokkoreli avamispidustustest. O.Elts juhatas 30. apr. Finlandia-talos toimunud kontserdil Soome Raadio SO-d. P.Vähi teos "Supreme Silence" kõlas kahel muusikafestivalil Saksamaal. Läti klaveriduo esitas rahvusvahelisel klaveriduode festivalil Lätis ja Leedus R.Kangro pala "O Sancta Simplicitas!"

An Interactive Simulation Tool for Production Planning in Bacon Factories

DEFF Research Database (Denmark)

Nielsen, Jens Frederik Dalsgaard; Nielsen, Kirsten Mølgaard

1994-01-01

The paper describes an interactive simulation tool for production planning in bacon factories. The main aim of the tool is to make it possible to combine the production plans of all parts of the factory......The paper describes an interactive simulation tool for production planning in bacon factories. The main aim of the tool is to make it possible to combine the production plans of all parts of the factory...

Production Planning with Respect to Uncertainties. Simulator Based Production Planning of Average Sized Combined Heat and Power Production Plants; Produktionsplanering under osaekerhet. Simulatorbaserad produktionsplanering av medelstora kraftvaermeanlaeggningar

Energy Technology Data Exchange (ETDEWEB)

Haeggstaahl, Daniel [Maelardalen Univ., Vaesteraas (Sweden); Dotzauer, Erik [AB Fortum, Stockholm (Sweden)

2004-12-01

Production planning in Combined Heat and Power (CHP) systems is considered. The focus is on development and use of mathematical models and methods. Different aspects on production planning are discussed, including weather and load predictions. Questions relevant on the different planning horizons are illuminated. The main purpose with short-term (one week) planning is to decide when to start and stop the production units, and to decide how to use the heat storage. The main conclusion from the outline of pros and cons of commercial planning software are that several are using Mixed Integer Programming (MIP). In that sense they are similar. Building a production planning model means that the planning problem is formulated as a mathematical optimization problem. The accuracy of the input data determines the practical detail level of the model. Two alternatives to the methods used in today's commercial programs are proposed: stochastic optimization and simulator-based optimization. The basic concepts of mathematical optimization are outlined. A simulator-based model for short-term planning is developed. The purpose is to minimize the production costs, depending on the heat demand in the district heating system, prices of electricity and fuels, emission taxes and fees, etc. The problem is simplified by not including any time-linking conditions. The process model is developed in IPSEpro, a heat and mass-balance software from SimTech Simulation Technology. TOMLAB, an optimization toolbox in MATLAB, is used as optimizer. Three different solvers are applied: glcFast, glcCluster and SNOPT. The link between TOMLAB and IPSEpro is accomplished using the Microsoft COM technology. MATLAB is the automation client and contains the control of IPSEpro and TOMLAB. The simulator-based model is applied to the CHP plant in Eskilstuna. Two days are chosen and analyzed. The optimized production is compared to the measured. A sensitivity analysis on how variations in outdoor

Ways of looking ahead: hierarchical planning in language production.

Science.gov (United States)

Lee, Eun-Kyung; Brown-Schmidt, Sarah; Watson, Duane G

2013-12-01

It is generally assumed that language production proceeds incrementally, with chunks of linguistic structure planned ahead of speech. Extensive research has examined the scope of language production and suggests that the size of planned chunks varies across contexts (Ferreira & Swets, 2002; Wagner & Jescheniak, 2010). By contrast, relatively little is known about the structure of advance planning, specifically whether planning proceeds incrementally according to the surface structure of the utterance, or whether speakers plan according to the hierarchical relationships between utterance elements. In two experiments, we examine the structure and scope of lexical planning in language production using a picture description task. Analyses of speech onset times and word durations show that speakers engage in hierarchical planning such that structurally dependent lexical items are planned together and that hierarchical planning occurs for both direct and indirect dependencies. Copyright © 2013 Elsevier B.V. All rights reserved.

Scaling-up the biomass production of Cymbopogon citratus L. in temporary immersion system

Directory of Open Access Journals (Sweden)

Elisa Quiala

2014-04-01

Full Text Available Shoot-tips, collected from greenhouse-grown plants of Cymbopogon citratus L. (lemmon grass, were incubated on a semi-solid Murashige and Skoog (MS medium with 30% (w/v sucrose, and supplemented with 0.89 µM 6-benzyladenine (BA. After three weeks of culture shoots were individualized and then inoculated in 10 litres temporary immersion system (TIS containing 3 litres of the same basal MS liquid medium. The effects of three immersion frequency (immersion every 12, 6 and 4 hours on the production of biomass were studied. Three inoculum densities (forty, fifty and sixty shoots/TIS were also tested. The biomass growth was inûuenced by the immersion frequency. The highest proliferation rate (17.3 shoots/explants and the plant length (45.2 cm were obtained in plants immersed every 4 h. Also, the fresh and dry biomass weight (153.4 gFW and 24.8 gDW, respectively were higher in this treatment. The maximum biomass accumulation (185.2 gFW and 35.2 gDW was achieved after 30 days of culture when an inoculum density of 60 explants per TIS was used. For the first time, biomass of C. citratus has been produced in10 litres TIS. These results represent the first step in the scaling-up the biomass production of this medicinal plant in large temporary immersion bioreactors. Key words: automation, biomass growth, lemmon grass medicinal plant, tissue culture

Interface between the production plan and the master production schedule in assembly environments

OpenAIRE

Moya Navarro, Marcos; Sánchez Brenes, Magaly

2012-01-01

In a production environment there is a direct relationship between the market and the manufacturing process of goods.When production is immersed in an assembly environment, the process of production planning and scheduling becomes complex, and the enterprises have the risk of losing competitive advantages in terms of not meeting delivery dates and production high costs. Linear programming has become an appropriate tool for production planning and scheduling in complex manufacturing environmen...

A model for marketing planning for new products

DEFF Research Database (Denmark)

Martensen, Anne

1993-01-01

awareness model. The model can be used to generate improved marketing plans. In this connection, it is important that the model includes the marketing variables, for it is only in this way that the model can be used for marketing plan optimization. It is predicted that a future direction of development...... and use of sales forecasting models for new products will be within optimization of the marketing plan for launching a new product, and not only as a tool for forecasting sales for just one marketing plan....

Saddle-fin cell transistors with oxide etch rate control by using tilted ion implantation (TIS-fin) for sub-50-nm DRAMs

International Nuclear Information System (INIS)

Yoo, Min Soo; Choi, Kang Sik; Sun, Woo Kyung

2010-01-01

As DRAM cell pitch size decreases, the need for a high performance transistor is increasing. Though saddle-fin (S-fin) transistors have superior characteristics, S-fin transistors are well known to be more sensitive to process variation. To make uniform S-fin transistors, for the first time, we developed a new fin formation method using tilted ion implantation along the wordline direction after a recess gate etch. Due to the increased etch rate of the oxide film by ion implantation damage, fins are made at the bottom channel of the recess gate after wet etching. The resulting tilt implanted saddle-fin (TIS-fin) transistor has remarkably improved characteristics, such as ∼8% subthreshold swing (SS) and a 40% drain induced barrier lowering (DIBL) decrease. Especially, the TIS-fin with a neutral dopant has a reduced threshold voltage (Vth) variation within a wafer (<100 mV), which is comparable with that of a mass-produced sphere-shaped recessed channel array transistor (SRCAT).

A review of planning models for maintenance and production.

NARCIS (Netherlands)

G. Budai-Balke (Gabriella); R. Dekker (Rommert); R.P. Nicolai (Robin)

2006-01-01

textabstractIn this article we give an overview of the relation between planning of maintenance and production. On the one hand we consider production planning and scheduling models in which failures and maintenance aspects are taken into account. Next we discuss the planning of maintenance

Energy-Performance as a driver for optimal production planning

International Nuclear Information System (INIS)

Salahi, Niloofar; Jafari, Mohsen A.

2016-01-01

Highlights: • A 2-dimensional Energy-Performance measure is proposed for energy aware production. • This is a novel approach integrates energy efficiency with production requirements. • This approach simultaneously incorporates machine and process related specifications. • The problem is solved as stochastic MILP with constraints addressing risk averseness. • The optimization is illustrated for 2 cases of single and serial machining operation. • Impact of various electricity pricing schemes on proposed production plan is analyzed. - Abstract: In this paper, we present energy-aware production planning using a two-dimensional “Energy-Performance” measure. With this measure, the production plan explicitly takes into account machine-level requirements, process control strategies, product types and demand patterns. The “Energy-Performance” measure is developed based on an existing concept, namely, “Specific Energy” at machine level. It is further expanded to an “Energy-Performance” profile for a production line. A production planning problem is formulated as a stochastic MILP with risk-averse constraints to account for manufacturer’s risk averseness. The objective is to attain an optimal production plan that minimizes the total loss distribution subject to system throughput targets, probabilistic risk constraints and constraints imposed by the underlying “Energy-Performance” pattern. Electricity price and demand per unit time are assumed to be stochastic. Conditional Value at Risk (CVaR) of loss distributions is used as the manufacturer’s risk measure. Both single-machine and production lines are studied for different profiles and electricity pricing schemes. It is shown that the shape of “Energy-Performance” profile can change optimal plans.

The suppression of UT tis using MPO constant Q split spectrum processing

International Nuclear Information System (INIS)

Koo, Kil Mo; Jun, Kye Suk

1997-01-01

It is very important for ultrasonic test method to evaluate the integrity of the class I components in nuclear power plants. However, as the ultrasonic test is affected by internal structures and configurations of test materials, backscattering, that is, time invariant signal(TIS) is generated in large grain size materials. Due to the above reason, the received signal results in tow signal to noise(S/N) ratio. Split spectrum processing (SSP) technique is effective to suppress the time invariant signal like a grain noise. The conventional SSP technique, however, has been applied to unique algorithm. This paper shows that MPO(minimization and polarity threshold) algorithm which is applied simultaneously two algorithms to be utilized, and the signal processing time was shorten by using the new constant-Q SSP with the finite impulse response(FIR) filter of which frequency to bandwidth ratio is constant and the optimum parameters were analysed for the signal processing to longitudinal wave and shear wave with the same condition of inspection on nuclear power plant site. Moreover, the new ultrasonic test instrument, the reference block of the same product form and material specification, stainless steel test specimens and copper test specimens were designed and fabricated for the application of the new SSP technique. As the result of experimental test with new ultrasonic test instrument and test specimens, the signal to noise ratio was improved by applying the new SSP technique.

Evaluation of a Leadership Program for First Nations, Métis, and Inuit Youth: Stories of Positive Youth Development and Community Engagement

Science.gov (United States)

Halsall, Tanya; Forneris, Tanya

2018-01-01

First Nations, Métis, and Inuit (FNMI) youth experience many health disparities in comparison with their mainstream Canadian peers. Researchers have recommended that interventions developed to enhance health and well-being for FNMI youth apply a strengths-based approach that acknowledges contextual challenges. This article uses a qualitative…

Electronic structure of the misfit layer compound (SnS)(1.20)TiS2 : Band structure calculations and photoelectron spectra

NARCIS (Netherlands)

Fang, CM; deGroot, RA; Wiegers, GA; Haas, C

1996-01-01

In order to understand the electronic structure of the incommensurate misfit layer compound (SnS)(1.20)TiS2 we carried out an ab initio band structure calculation in the supercell approximation. The band structure is compared with that of the components 1T-TiS2 and hypothetical SnS with a similar

Electronic structure of the misfit layer compound (SnS)1.20TiS2 : band structure calculations and photoelectron spectra

NARCIS (Netherlands)

Fang, C.M.; Groot, R.A. de; Wiegers, G.A.; Haas, C.

1996-01-01

In order to understand the electronic structure of the incommensurate misfit layer compound (SnS)1.20TiS2 we carried out an ab initio band structure calculation in the supercell approximation. The band structure is compared with that of the components 1T-TiS2 and hypothetical SnS with a similar

Global Threat Reduction Initiative Fuel Thermo-Physical Characterization Project: Sample Management Plan

Energy Technology Data Exchange (ETDEWEB)

Casella, Amanda J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pereira, Mario M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Steen, Franciska H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2013-01-01

This sample management plan provides guidelines for sectioning, preparation, acceptance criteria, analytical path, and end-of-life disposal for the fuel element segments utilized in the Global Threat Reduction Initiative (GTRI), Fuel Thermo-Physical Characterization Project. The Fuel Thermo-Physical Characterization Project is tasked with analysis of irradiated Low Enriched Uranium (LEU) Molybdenum (U-Mo) fuel element samples to support the GTRI conversion program. Sample analysis may include optical microscopy (OM), scanning electron microscopy (SEM) fuel-surface interface analysis, gas pycnometry (density) measurements, laser flash analysis (LFA), differential scanning calorimetry (DSC), thermogravimetry and differential thermal analysis with mass spectroscopy (TG /DTA-MS), Inductively Coupled Plasma Spectrophotometry (ICP), alpha spectroscopy, and Thermal Ionization Mass Spectroscopy (TIMS). The project will utilize existing Radiochemical Processing Laboratory (RPL) operating, technical, and administrative procedures for sample receipt, processing, and analyses. Test instructions (TIs), which are documents used to provide specific details regarding the implementation of an existing RPL approved technical or operational procedure, will also be used to communicate to staff project specific parameters requested by the Principal Investigator (PI). TIs will be developed, reviewed, and issued in accordance with the latest revision of the RPL-PLN-700, RPL Operations Plan. Additionally, the PI must approve all project test instructions and red-line changes to test instructions.

A simple approximation of productivity scores of fuzzy production plans

DEFF Research Database (Denmark)

Hougaard, Jens Leth

2005-01-01

This paper suggests a simple approximation procedure for the assessment of productivity scores with respect to fuzzy production plans. The procedure has a clear economic interpretation and all the necessary calculations can be performed in a spreadsheet making it highly operational...

Virtual Factory Framework for Supporting Production Planning and Control.

Science.gov (United States)

Kibira, Deogratias; Shao, Guodong

2017-01-01

Developing optimal production plans for smart manufacturing systems is challenging because shop floor events change dynamically. A virtual factory incorporating engineering tools, simulation, and optimization generates and communicates performance data to guide wise decision making for different control levels. This paper describes such a platform specifically for production planning. We also discuss verification and validation of the constituent models. A case study of a machine shop is used to demonstrate data generation for production planning in a virtual factory.

PHOTOELECTRON-SPECTROSCOPY STUDY OF THE ELECTRONIC-STRUCTURE OF THE INCOMMENSURATE INTERGROWTH COMPOUNDS (SBS)(1.15)(TIS2)(N) WITH N=1, 2

NARCIS (Netherlands)

REN, Y; HAAS, C; WIEGERS, GA

1995-01-01

The electronic structure of the inorganic misfit-layer compounds (SbS)(1.15)(TiS2)(n) (n = 1,2) has been investigated using x-ray photoemission spectroscopy (XPS), ultraviolet photoemission spectroscopy (UPS) and x-ray absorption spectroscopy (XAS). These compounds are built of alternating modulated

New Production Reactors Program Plan

Energy Technology Data Exchange (ETDEWEB)

1990-12-01

Part I of this New Production Reactors (NPR) Program Plan: describes the policy basis of the NPR Program; describes the mission and objectives of the NPR Program; identifies the requirements that must be met in order to achieve the mission and objectives; and describes and assesses the technology and siting options that were considered, the Program's preferred strategy, and its rationale. The implementation strategy for the New Production Reactors Program has three functions: Linking the design, construction, operation, and maintenance of facilities to policies requirements, and the process for selecting options. The development of an implementation strategy ensures that activities and procedures are consistent with the rationale and analysis underlying the Program. Organization of the Program. The strategy establishes plans, organizational structure, procedures, a budget, and a schedule for carrying out the Program. By doing so, the strategy ensures the clear assignment of responsibility and accountability. Management and monitoring of the Program. Finally, the strategy provides a basis for monitoring the Program so that technological, cost, and scheduling issues can be addressed when they arise as the Program proceeds. Like the rest of the Program Plan, the Implementation Strategy is a living document and will be periodically revised to reflect both progress made in the Program and adjustments in plans and policies as they are made. 21 figs., 5 tabs.

New Production Reactors Program Plan

International Nuclear Information System (INIS)

1990-12-01

Part I of this New Production Reactors (NPR) Program Plan: describes the policy basis of the NPR Program; describes the mission and objectives of the NPR Program; identifies the requirements that must be met in order to achieve the mission and objectives; and describes and assesses the technology and siting options that were considered, the Program's preferred strategy, and its rationale. The implementation strategy for the New Production Reactors Program has three functions: Linking the design, construction, operation, and maintenance of facilities to policies requirements, and the process for selecting options. The development of an implementation strategy ensures that activities and procedures are consistent with the rationale and analysis underlying the Program. Organization of the Program. The strategy establishes plans, organizational structure, procedures, a budget, and a schedule for carrying out the Program. By doing so, the strategy ensures the clear assignment of responsibility and accountability. Management and monitoring of the Program. Finally, the strategy provides a basis for monitoring the Program so that technological, cost, and scheduling issues can be addressed when they arise as the Program proceeds. Like the rest of the Program Plan, the Implementation Strategy is a living document and will be periodically revised to reflect both progress made in the Program and adjustments in plans and policies as they are made. 21 figs., 5 tabs

Production planning and coronal stop deletion in spontaneous speech

Directory of Open Access Journals (Sweden)

James Tanner

2017-06-01

Full Text Available Many phonological processes can be affected by segmental context spanning word boundaries, which often lead to variable outcomes. This paper tests the idea that some of this variability can be explained by reference to production planning. We examine coronal stop deletion (CSD, a variable process conditioned by preceding and upcoming phonological context, in a corpus of spontaneous British English speech, as a means of investigating a number of variables associated with planning: Prosodic boundary strength, word frequency, conditional probability of the following word, and speech rate. From the perspective of production planning, (1 prosodic boundaries should affect deletion rate independently of following context; (2 given the locality of production planning, the effect of the following context should decrease at stronger prosodic boundaries; and (3 other factors affecting planning scope should modulate the effect of upcoming phonological material above and beyond the modulating effect of prosodic boundaries. We build a statistical model of CSD realization, using pause length as a quantitative proxy for boundary strength, and find support for these predictions. These findings are compatible with the hypothesis that the locality of production planning constrains variability in speech production, and have practical implications for work on CSD and other variable processes.

Geostatistics applied in mine production planning

Energy Technology Data Exchange (ETDEWEB)

Zerdin, F.; Markic, S.; Subelj, A. [NTF, Ljubljana (Slovenia)

1998-07-01

Long-term plan for lignite mine Velenje has been made by using a technical 'parametrisation' method where the basis for periodic, middle-term and short-term plans as well as for scheduling has already been fixed. Plans are presented by grade (heating value in GJ), quantity of ROM coal in tons and quantity of excavated material in cubic metre for each sequence of the seam or whole seam as well as for all working seams in the mines as a whole which correspond to a defined time period. Grade planning aims at achieving uniform product quality to meet contractual obligations. 17 refs., 10 figs.

Integrated production planning and water management in the food industry: A cheese production case study

NARCIS (Netherlands)

Pulluru, Sai Jishna; Akkerman, Renzo; Hottenrott, Andreas

2017-01-01

Efficient water management is increasingly relevant in the food industry. Exploiting water reuse opportunities in planning production activities is a key part of this. We study integrated water management and production planning in cheese production. For this, we develop a water-integrated lot

Aggregate Production Planning, Casestudy in a Medium-sized Industry of the Rubber Production Line in Ecuador.

Science.gov (United States)

Rosero-Mantilla, César; Sánchez-Sailema, Mayra; Sánchez-Rosero, Carlos; Galleguillos-Pozo, Rosa

2017-06-01

This research aims to improve the productivity in the rubber line of a medium-sized industry by increasing the production capacities through the use of the Aggregate Production Planning model. For this purpose an analysis of the production processes of the line was made and the aggregate plan was defined evaluating two strategies: Exact Production Plan (Zero Inventory) and Constant Workforce Plan (Vary Inventory) by studying the costs of both inventory maintenance and workforce. It was also determined how the installed capacity was used with the standards of the rubber line and measures for decreasing production costs were proposed. It was proven that only 70% of the plant capacity was being used so it could be possible to produce more units and to obtain a bigger market for the products of this line.+

Phonological Advance Planning in Sentence Production

Science.gov (United States)

Oppermann, Frank; Jescheniak, Jorg D.; Schriefers, Herbert

2010-01-01

Our study addresses the scope of phonological advance planning during sentence production using a novel experimental procedure. The production of German sentences in various syntactic formats (SVO, SOV, and VSO) was cued by presenting pictures of the agents of previously memorized agent-action-patient scenes. To tap the phonological activation of…

A deterministic aggregate production planning model considering quality of products

International Nuclear Information System (INIS)

Madadi, Najmeh; Wong, Kuan Yew

2013-01-01

Aggregate Production Planning (APP) is a medium-term planning which is concerned with the lowest-cost method of production planning to meet customers' requirements and to satisfy fluctuating demand over a planning time horizon. APP problem has been studied widely since it was introduced and formulated in 1950s. However, in several conducted studies in the APP area, most of the researchers have concentrated on some common objectives such as minimization of cost, fluctuation in the number of workers, and inventory level. Specifically, maintaining quality at the desirable level as an objective while minimizing cost has not been considered in previous studies. In this study, an attempt has been made to develop a multi-objective mixed integer linear programming model that serves those companies aiming to incur the minimum level of operational cost while maintaining quality at an acceptable level. In order to obtain the solution to the multi-objective model, the Fuzzy Goal Programming approach and max-min operator of Bellman-Zadeh were applied to the model. At the final step, IBM ILOG CPLEX Optimization Studio software was used to obtain the experimental results based on the data collected from an automotive parts manufacturing company. The results show that incorporating quality in the model imposes some costs, however a trade-off should be done between the cost resulting from producing products with higher quality and the cost that the firm may incur due to customer dissatisfaction and sale losses.

Strain-induced enhancement of thermoelectric performance of TiS2 monolayer based on first-principles phonon and electron band structures

Science.gov (United States)

Li, Guanpeng; Yao, Kailun; Gao, Guoying

2018-01-01

Using first-principle calculations combined with Boltzmann transport theory, we investigate the biaxial strain effect on the electronic and phonon thermal transport properties of a 1 T (CdI2-type) structural TiS2 monolayer, a recent experimental two-dimensional (2D) material. It is found that the electronic band structure can be effectively modulated and that the band gap experiences an indirect-direct-indirect transition with increasing tensile strain. The band convergence induced by the tensile strain increases the Seebeck coefficient and the power factor, while the lattice thermal conductivity is decreased under the tensile strain due to the decreasing group velocity and the increasing scattering chances between the acoustic phonon modes and the optical phonon modes, which together greatly increase the thermoelectric performance. The figure of merit can reach 0.95 (0.82) at an 8 percent tensile strain for the p-type (n-type) doping, which is much larger than that without strain. The present work suggests that the TiS2 monolayer is a good candidate for 2D thermoelectric materials, and that biaxial strain is a powerful tool with which to enhance thermoelectric performance.

Pdvsa plans to hike productive capacity

International Nuclear Information System (INIS)

Anon.

1992-01-01

This paper reports that Venezuela's state oil company plans to jump its productive capacity by 117,000 b/d to 2.92 million b/d this year. Petroleos de Venezuela also projects sizable increases for oil and gas reserves and plans record spending in 1992. Meantime, Pdvsa is sounding a warning again about the Venezuelan government's excessive tax take amid debate within the company about spending priorities

TiS2 and ZrS2 single- and double-wall nanotubes: first-principles study.

Science.gov (United States)

Bandura, Andrei V; Evarestov, Robert A

2014-02-15

Hybrid density functional theory has been applied for investigations of the electronic and atomic structure of bulk phases, nanolayers, and nanotubes based on titanium and zirconium disulfides. Calculations have been performed on the basis of the localized atomic functions by means of the CRYSTAL-2009 computer code. The full optimization of all atomic positions in the regarded systems has been made to study the atomic relaxation and to determine the most favorable structures. The different layered and isotropic bulk phases have been considered as the possible precursors of the nanotubes. Calculations on single-walled TiS2 and ZrS2 nanotubes confirmed that the nanotubes obtained by rolling up the hexagonal crystalline layers with octahedral 1T morphology are the most stable. The strain energy of TiS2 and ZrS2 nanotubes is small, does not depend on the tube chirality, and approximately obeys to D(-2) law (D is nanotube diameter) of the classical elasticity theory. It is greater than the strain energy of the similar TiO2 and ZrO2 nanotubes; however, the formation energy of the disulfide nanotubes is considerably less than the formation energy of the dioxide nanotubes. The distance and interaction energy between the single-wall components of the double-wall nanotubes is proved to be close to the distance and interaction energy between layers in the layered crystals. Analysis of the relaxed nanotube shape using radial coordinate of the metal atoms demonstrates a small but noticeable deviation from completely cylindrical cross-section of the external walls in the armchair-like double-wall nanotubes. Copyright © 2013 Wiley Periodicals, Inc.

Generalized production planning problem under interval uncertainty

Directory of Open Access Journals (Sweden)

Samir A. Abass

2010-06-01

Full Text Available Data in many real life engineering and economical problems suffer from inexactness. Herein we assume that we are given some intervals in which the data can simultaneously and independently perturb. We consider the generalized production planning problem with interval data. The interval data are in both of the objective function and constraints. The existing results concerning the qualitative and quantitative analysis of basic notions in parametric production planning problem. These notions are the set of feasible parameters, the solvability set and the stability set of the first kind.

Short-term hydropower production planning by stochastic programming

DEFF Research Database (Denmark)

Fleten, Stein-Erik; Kristoffersen, Trine

2008-01-01

-term production planning a matter of spatial distribution among the reservoirs of the plant. Day-ahead market prices and reservoir inflows are, however, uncertain beyond the current operation day and water must be allocated among the reservoirs in order to strike a balance between current profits and expected......Within the framework of multi-stage mixed-integer linear stochastic programming we develop a short-term production plan for a price-taking hydropower plant operating under uncertainty. Current production must comply with the day-ahead commitments of the previous day which makes short...

Polymorphic Uncertain Linear Programming for Generalized Production Planning Problems

Directory of Open Access Journals (Sweden)

Xinbo Zhang

2014-01-01

Full Text Available A polymorphic uncertain linear programming (PULP model is constructed to formulate a class of generalized production planning problems. In accordance with the practical environment, some factors such as the consumption of raw material, the limitation of resource and the demand of product are incorporated into the model as parameters of interval and fuzzy subsets, respectively. Based on the theory of fuzzy interval program and the modified possibility degree for the order of interval numbers, a deterministic equivalent formulation for this model is derived such that a robust solution for the uncertain optimization problem is obtained. Case study indicates that the constructed model and the proposed solution are useful to search for an optimal production plan for the polymorphic uncertain generalized production planning problems.

Innovation Cycles Concerning Strategic Planning of Product-Service-Systems

OpenAIRE

Hepperle, Clemens;Mörtl, Markus;Lindemann, Udo

2017-01-01

This paper proposes a research program for identifying, understanding and describing innovation cycles concerning strategic planning of product-service-systems. A general overview about the background of cycle management in innovation processes, which the proposed research program is part of, is given before focusing cycles concerning strategic planning. As companies offer more and more complex products in order to satisfy market needs, the innovation process of such products becomes also mor...

Analytic network process (ANP approach for product mix planning in railway industry

Directory of Open Access Journals (Sweden)

Hadi Pazoki Toroudi

2016-08-01

Full Text Available Given the competitive environment in the global market in recent years, organizations need to plan for increased profitability and optimize their performance. Planning for an appropriate product mix plays essential role for the success of most production units. This paper applies analytical network process (ANP approach for product mix planning for a part supplier in Iran. The proposed method uses four criteria including cost of production, sales figures, supply of raw materials and quality of products. In addition, the study proposes different set of products as alternatives for production planning. The preliminary results have indicated that that the proposed study of this paper could increase productivity, significantly.

Production planning of a perishable product with lead time and non-stationary demand

NARCIS (Netherlands)

Pauls-Worm, K.G.J.; Haijema, R.; Hendrix, E.M.T.; Rossi, R.; Vorst, van der J.G.A.J.

2012-01-01

We study a production planning problem for a perishable product with a fixed lifetime, under a service-level constraint. The product has a non-stationary stochastic demand. Food supply chains of fresh products like cheese and several crop products, are characterised by long lead times due to

Evaluación farmacoterapéutica y evolutiva de uveítis crónicas y recurrentes no infecciosas

Directory of Open Access Journals (Sweden)

Mireya Benítez Cartaya

Full Text Available Objetivos: evaluar el tratamiento farmacológico e identificar los factores pronósticos en una evolución clínica desfavorable con uveítis crónicas y recurrentes no infecciosas, en el Instituto Cubano Oftalmología "Ramón Pando Ferrer" durante el período 2012-2013. Métodos: se realizó un estudio de utilización de medicamentos. Se efectuó un diseño de cohorte retrospectivo evaluativo y un estudio transversal analítico de factores pronósticos. Fueron evaluados 116 pacientes. Las variables utilizadas correspondieron a la evaluación farmacoterapéutica: selección del medicamento, pauta de administración y causas de incumplimiento terapéutico. Para la evolución clínica desfavorable se analizaron variables sociodemográficas y clínicas. Se calcularon frecuencias absolutas y relativas. Se realizó un análisis univariado. Las variables significativas a la evolución se incluyeron en el modelo de regresión logística múltiple. Resultados: no existieron errores en la prescripción en el 100 % de los evaluados. El 15,5 % de los pacientes no cumplieron con el tratamiento prescrito; 83,3 % se relacionó con la presencia de reacciones adversas y 33,3 % con la falta de disponibilidad. El 57 % presentó efectos adversos por corticoesteroides y el 39 % por inmunosupresores. El curso clínico crónico y la localización resultaron factores influyentes en una evolución desfavorable. Conclusiones: la evaluación farmacoterapéutica en el caso de las uveítis crónicas es adecuada. No existen errores en la prescripción. Las causas más frecuentes de incumplimiento terapéutico son la suspensión del tratamiento por efectos adversos, la falta de disponibilidad de inmunosupresores y la alternativa biológica. El curso clínico crónico y la localización de las uveítis pueden considerarse como un factor pronóstico en la evolución desfavorable de esta enfermedad.

Proposing an Aggregate Production Planning Model by Goal Programming Approach, a Case Study

Directory of Open Access Journals (Sweden)

Mansoureh Farzam Rad

2014-06-01

Full Text Available Production planning is one of the most important functions in the process of production management. Production planning in the intermediate range of time is termed as aggregate production planning (APP. Aggregate production planning is an important upper level planning activity in a production management system. The present study tries to suggest an aggregate production planning model for products of Hafez tile factory during one year. Due to this fact that the director of the company seeks 3 main objectives to determine the optimal production rate, the linear goal planning method was employed. After solving the problem, in order to examine the efficiency and the distinctiveness of this method in compare to linear programming, the problem was modeled just by considering one objective then was solved by linear programming approach. The findings revealed the goal programming with multi objectives resulted more appropriate solution rather than linear programming with just one objective.

PLANNING VESSEL BODY SECTION PRODUCTION

Directory of Open Access Journals (Sweden)

A. G. Grivachevsky

2015-01-01

Full Text Available A problem of planning production of a vessel body section is considered. The problem is reduced to the classic Johnson’s tree-machine flow-shop scheduling problem. A genetic algorithm and computer experiment to compare efficiency of this algorithm and the algorithm of full enumeration are described.

Production Planning and Planting Pattern Scheduling Information System for Horticulture

Science.gov (United States)

Vitadiar, Tanhella Zein; Farikhin; Surarso, Bayu

2018-02-01

This paper present the production of planning and planting pattern scheduling faced by horticulture farmer using two methods. Fuzzy time series method use to predict demand on based on sales amount, while linear programming is used to assist horticulture farmers in making production planning decisions and determining the schedule of cropping patterns in accordance with demand predictions of the fuzzy time series method, variable use in this paper is size of areas, production advantage, amount of seeds and age of the plants. This research result production planning and planting patterns scheduling information system with the output is recommendations planting schedule, harvest schedule and the number of seeds will be plant.

Freezing the Master Production Schedule Under Rolling Planning Horizons

OpenAIRE

V. Sridharan; William L. Berry; V. Udayabhanu

1987-01-01

The stability of the Master Production Schedule (MPS) is a critical issue in managing production operations with a Material Requirements Planning System. One method of achieving stability is to freeze some portion or all of the MPS. While freezing the MPS can limit the number of schedule changes, it can also produce an increase in production and inventory costs. This paper examines three decision variables in freezing the MPS: the freezing method, the freeze interval length, and the planning ...

Forest management planning for timber production: a sequential approach

Science.gov (United States)

Krishna P. Rustagi

1978-01-01

Explicit forest management planning for timber production beyond the first few years at any time necessitates use of information which can best be described as suspect. The two-step approach outlined here concentrates on the planning strategy over the next few years without losing sight of the long-run productivity. Frequent updating of the long-range and short-range...

Application of PIMS Software in Monthly Planning of Refinery Production

Institute of Scientific and Technical Information of China (English)

无

2005-01-01

This article describes the application of the PIMS software in formulating monthly refining production plan. Application of the PIMS software can help to solve a series of problems related with monthly plan of refining production such as optimized selection of crude and feedstocks, optimized selection of production scale and processing scheme, identification of bottlenecks and their mitigation,optimized selection of turnaround time and optimized selection of operating regime, which have increased the economic benefits of refining enterprises. With the further development and improvement of models the PIMS software will play an increasingly important role in formulating monthly plans of refining operations and production management at refineries. This article also explores the problems existing in refinery monthly planning, and has made recommendations on developing and improving models and reporting system, enhancement of basic data acquisition, model maintenance personnel and staff training.

Preferences in Data Production Planning

Science.gov (United States)

Golden, Keith; Brafman, Ronen; Pang, Wanlin

2005-01-01

This paper discusses the data production problem, which consists of transforming a set of (initial) input data into a set of (goal) output data. There are typically many choices among input data and processing algorithms, each leading to significantly different end products. To discriminate among these choices, the planner supports an input language that provides a number of constructs for specifying user preferences over data (and plan) properties. We discuss these preference constructs, how we handle them to guide search, and additional challenges in the area of preference management that this important application domain offers.

Coordinated supply chain dynamic production planning model

Science.gov (United States)

Chandra, Charu; Grabis, Janis

2001-10-01

Coordination of different and often contradicting interests of individual supply chain members is one of the important issues in supply chain management because the individual members can not succeed without success of the supply chain and vice versa. This paper investigates a supply chain dynamic production planning problem with emphasis on coordination. A planning problem is formally described using a supply chain kernel, which defines supply chain configuration, management policies, available resources and objectives both at supply chain or macro and supply chain member or micro levels. The coordinated model is solved in order to balance decisions made at the macro and micro levels and members' profitability is used as the coordination criterion. The coordinated model is used to determine inventory levels and production capacity across the supply chain. Application of the coordinated model distributes costs burden uniformly among supply chain members and preserves overall efficiency of the supply chain. Influence of the demand series uncertainty is investigated. The production planning model is a part of the integrated supply chain decision modeling system, which is shared among the supply chain members across the Internet.

Fiscal planning of private electricity production projects

International Nuclear Information System (INIS)

Gauthier, R.

2002-01-01

Various fiscal considerations frequently encountered in the context of the planning of private electricity production projects were described. Two major themes were discussed: 1) the different jurisdictional vehicles that can be used during the planning of private electricity production projects and the associated fiscal considerations, and 2) the two main fiscal incentives of the Income Tax Act (Canada) which could impact on the financing and operation costs of such a project, namely the accelerated amortization and the possibility of deducting the costs associated to renewable energies and energy savings in Canada. This was a general presentation that did not go into specific details and did not represent a legal opinion. refs

Planning organization and productivity simulation tool for maritime container terminals

Directory of Open Access Journals (Sweden)

B. Beškovnik

2010-09-01

Full Text Available The article describes a proposed planning organization and productivity simulation tool, with a special emphasis on orientations to the optimization of operations in a maritime container terminal. With the application of an adequate model frame for traffic and technical-technologic forecasting, infrastructure and manpower planning and productivity simulation are possible to measure and increase the productivity in the whole subsystem of the maritime container terminal. The emphasis is mainly put on setting up planning organization in order to collect important information and consequently to raise productivity. This is the main task and goal of terminal management that must develop elements and strategies for optimal operational and financial production. An adequate planning structure must use simplified but efficient simulation tools enabling owners and management to take a vast number of adequate financial and operational decisions. Considering all important and very dynamic facts in container and shipping industry, the proposed simulation tool gives a helpful instrument for checking productivity and its time variation and monitoring a competitive position of a certain maritime terminal with the terminals from the same group. Therefore, the management of every maritime container terminal must establish an appropriate internal planning system as a mechanism for strategic decision support relating basically to the assessment of the best development and optimization solutions for the infrastructure and suprastructure of the entire system.

Adjuvant Chemotherapy Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0 After Preoperative Radiotherapy and Surgery from a Population-Based Propensity Score Analysis.

Science.gov (United States)

Hu, Xiang; Li, Ya-Qi; Li, Qing-Guo; Ma, Yan-Lei; Peng, Jun-Jie; Cai, San-Jun

2018-04-19

Adjuvant chemotherapy is currently offered routinely, as standard, after radical resection for patients with rectal cancer receiving neo-adjuvant chemoradiation. However, the efficacy of adjuvant chemotherapy in patients with ypTis-2N0M0 has not been documented to the same extent, and the survival benefit remained controversial. The purpose of this work was to determine the role of chemotherapy in patients with ypTis-2N0M0 classification. Data were obtained from the Surveillance, Epidemiology, and End Results database ( n  = 4,217). A propensity score model was utilized to balance baseline covariates. Of the 4,217 included patients, 335 with ypTis-2N0M0 did not receive adjuvant chemotherapy. There were comparable cancer-specific survivals (CSS) between those undergoing adjuvant chemotherapy or not (log-rank test = 0.136, p  = .712) in the overall sample. After propensity score matching, the cancer-specific survival did not differ between the chemotherapy and observation groups (log-rank test = 0.089, p  = .765). Additionally, the Cox model did not demonstrate adjuvant chemotherapy as the prognostic factor, with hazard ratio = 0.95 (95% confidence interval 0.69-1.32) for CSS. Furthermore, the 10-year cumulative CSS was 78.7% and 79.4% between the chemotherapy and observation groups, indicating no significance, and no impact of adjuvant chemotherapy on survival was observed in different subgroups stratified by T stage, histological grade, histology, lymph nodes, and tumor size. Patients with ypTis-2N0 rectal cancer did not benefit from adjuvant chemotherapy after preoperative radiology and radical surgery in this cohort study. These results provided new insight into the routine use of adjuvant chemotherapy for patients with rectal cancer with completed neo-adjuvant radiotherapy and curative surgery. Inconsistent recommendations for patients with rectal cancer receiving neo-adjuvant chemoradiation are offered by clinical guidelines. Adjuvant

A Graphical Interactive Simulation Environment for Production Planning in Bacon Factories

DEFF Research Database (Denmark)

Nielsen, Kirsten Mølgaard; Nielsen, Jens Frederik Dalsgaard

1994-01-01

The paper describes a graphical interactive simulation tool for production planning in bacon factories........The paper describes a graphical interactive simulation tool for production planning in bacon factories.....

Graduate Student Project: Operations Management Product Plan

Science.gov (United States)

Fish, Lynn

2007-01-01

An operations management product project is an effective instructional technique that fills a void in current operations management literature in product planning. More than 94.1% of 286 graduates favored the project as a learning tool, and results demonstrate the significant impact the project had in predicting student performance. The author…

Global Production Planning Process considering the Supply Risk of Overseas Manufacturing Sites

Directory of Open Access Journals (Sweden)

Hosang Jung

2015-01-01

Full Text Available Although global manufacturers can produce most of their final products in local plants, they need to source components or parts from desirable overseas manufacturing partners at low cost in order to fulfill customer orders. In this global manufacturing environment, capacity information for planning is usually imprecise owing to the various risks of overseas plants (e.g., foreign governments’ policies and labor stability. It is therefore not easy for decision-makers to generate a global production plan showing the production amounts at local plants and overseas manufacturing facilities operated by manufacturing partners. In this paper, we present a new global production planning process considering the supply risk of overseas manufacturing sites. First, local experts estimate the supply capacity of an overseas plant using their judgment to determine when the risk could occur and how large the risk impact would be. Next, we run a global production planning model with the estimated supply capacities. The proposed process systematically adopts the qualitative judgments of local experts in the global production planning process and thus can provide companies with a realistic global production plan. We demonstrate the applicability of the proposed process with a real world case.

Multi-product dynamic advertisement planning in a segmented market

Directory of Open Access Journals (Sweden)

Aggarwal Sugandha

2017-01-01

Full Text Available In this paper, a dynamic multi-objective linear integer programming model is proposed to optimally distribute a firm’s advertising budget among multiple products and media in a segmented market. To make the media plan responsive to the changes in the market, the distribution is carried out dynamically by dividing the planning horizon into smaller periods. The model incorporates the effect of the previous period advertising reach on the current period (taken through retention factor, and it also considers cross-product effect of simultaneously advertising different products. An application of the model is presented for an insurance firm that markets five different products, using goal programming approach.

Phonological Planning during Sentence Production: Beyond the Verb.

Science.gov (United States)

Schnur, Tatiana T

2011-01-01

The current study addresses the extent of phonological planning during spontaneous sentence production. Previous work shows that at articulation, phonological encoding occurs for entire phrases, but encoding beyond the initial phrase may be due to the syntactic relevance of the verb in planning the utterance. I conducted three experiments to investigate whether phonological planning crosses multiple grammatical phrase boundaries (as defined by the number of lexical heads of phrase) within a single phonological phrase. Using the picture-word interference paradigm, I found in two separate experiments a significant phonological facilitation effect to both the verb and noun of sentences like "He opens the gate." I also altered the frequency of the direct object and found longer utterance initiation times for sentences ending with a low-frequency vs. high-frequency object offering further support that the direct object was phonologically encoded at the time of utterance initiation. That phonological information for post-verbal elements was activated suggests that the grammatical importance of the verb does not restrict the extent of phonological planning. These results suggest that the phonological phrase is unit of planning, where all elements within a phonological phrase are encoded before articulation. Thus, consistent with other action sequencing behavior, there is significant phonological planning ahead in sentence production.

[School meals: planning, production, distribution, and adequacy].

Science.gov (United States)

Issa, Raquel Carvalho; Moraes, Letícia Freitas; Francisco, Raquel Rocha Jabour; dos Santos, Luana Caroline; dos Anjos, Adriana Fernandez Versiani; Pereira, Simone Cardoso Lisboa

2014-02-01

To evaluate the planning, production, distribution, and nutritional adequacy of meals served at city schools. This descriptive cross-sectional study was conducted between March 2011 and April 2012 and included a representative sample (n = 42 schools) of extended shift city schools from Belo Horizonte, Minas Gerais, Brazil. Five meals from each school were randomly selected and analyzed by direct weighing. Production indicators and nutritional adequacy were evaluated in contrast to the recommendations of the city food security bureau and the Brazilian National Program of School Meals (PNAE). Seventy-nine percent of the analyzed meals did not meet the recommendations of the city food security bureau. The rate of waste (food left on plates) was acceptable at 4,90%, but the rates of cooked and not served food (7,06%) and counter leftovers (5,30%) were high. Both the city planned meals and the meals served in the schools were nutritionally inadequate in terms of the PNAE, particularly for children aged 11-15 years. There was a relationship between consumption by school staff and the amount of food that was cooked (r = 0.353; P planning, production, and distribution of school meals and of food and nutrition education in order to improve the quality of food and to reduce waste in schools.

Decision Model for Planning and Scheduling of Seafood Product Considering Traceability

Science.gov (United States)

Agustin; Mawengkang, Herman; Mathelinea, Devy

2018-01-01

Due to the global challenges, it is necessary for an industrial company to integrate production scheduling and distribution planning, in order to be more efficient and to get more economics advantages. This paper presents seafood production planning and scheduling of a seafood manufacture company which produces simultaneously multi kind of seafood products, located at Aceh Province, Indonesia. The perishability nature of fish highly restricts its storage duration and delivery conditions. Traceability is a tracking requirement to check whether the quality of the product is satisfied. The production and distribution planning problem aims to meet customer demand subject to traceability of the seafood product and other restrictions. The problem is modeled as a mixed integer linear program, and then it is solved using neighborhood search approach.

White Rose development plan amendment production volume increase

International Nuclear Information System (INIS)

2006-09-01

In January 2001, Husky Oil Operations Limited (Husky), in joint-venture with Petro-Canada, submitted a Benefits Plan for the White Rose Development to the Canada- Newfoundland and Labrador Offshore Petroleum Board (C-NLOPB). This revised document provided the case for requesting an increase in the facility maximum daily production rate and the average annual production rate for the White Rose field from 100,000 barrels per day (bpd) as stated in the approved White Rose Development Plan to 140,000 bpd. In order to determine the potential for increasing oil production through the Floating Production, Storage and Offloading (FPSO) vessel, two things were considered, namely the proper reservoir management of the White Rose field to ensure optimum resource recovery, and the capacity of the FPSO topsides processing system and supporting utilities to accommodate increased production. This document presented a detailed review of all the implications of increased production on the South White Rose Reservoir. In addition, the results from FPSO performance testing were reviewed, including a study of options for de-bottlenecking the process plant on the topsides and capacity testing of selected process streams and support systems. Vibration analysis was conducted before and during performance testing in July 2006 and a small number of areas addressed. The document also addressed flow metering, resource management, certifying authority review, safety plan revisions, environmental effects, as well as benefits to Canada and Newfoundland. 21 tabs., 60 refs

Simulation-optimization model for production planning in the blood supply chain.

Science.gov (United States)

Osorio, Andres F; Brailsford, Sally C; Smith, Honora K; Forero-Matiz, Sonia P; Camacho-Rodríguez, Bernardo A

2017-12-01

Production planning in the blood supply chain is a challenging task. Many complex factors such as uncertain supply and demand, blood group proportions, shelf life constraints and different collection and production methods have to be taken into account, and thus advanced methodologies are required for decision making. This paper presents an integrated simulation-optimization model to support both strategic and operational decisions in production planning. Discrete-event simulation is used to represent the flows through the supply chain, incorporating collection, production, storing and distribution. On the other hand, an integer linear optimization model running over a rolling planning horizon is used to support daily decisions, such as the required number of donors, collection methods and production planning. This approach is evaluated using real data from a blood center in Colombia. The results show that, using the proposed model, key indicators such as shortages, outdated units, donors required and cost are improved.

Enviromental Development Plan: special nuclear materials production

International Nuclear Information System (INIS)

1980-07-01

This Environmental Development Plan includes the process steps and facilities necessary for the production of plutonium and tritium for Government needs and the production of some other radioactive materials that will be used for heat and radiation sources by domestic and international customers. The production reactors and the spent fuel processing plants and their effluents are discussed, but the defense wastes from them are treated in a separate EDP. The scope does not include transportation, decontamination and decommissioning, safeguards and security, or use of the SNM products

Suicidal ideation among Métis adult men and women – associated risk and protective factors: findings from a nationally representative survey

OpenAIRE

Kumar, Mohan B.; Walls, Melissa; Janz, Teresa; Hutchinson, Peter; Turner, Tara; Graham, Catherine

2012-01-01

Objective: To determine the prevalence of suicidal ideation among Métis men and women (20-59 years) and identify its associated risk and protective factors using data from the nationally representative Aboriginal Peoples Survey (2006).Study design: Secondary analysis of previously collected data from a nationally representative cross-sectional survey.Results: Across Canada, lifetime suicidal ideation was reported by an estimated 13.3% (or an estimated 34,517 individuals) of the total populati...

Human cord blood suppressor T lymphocytes. II. Characterization of inducer of suppressor cells

International Nuclear Information System (INIS)

Cheng, H.; Delespesse, G.

1986-01-01

Previously, we reported an antigen nonspecific inducer of T suppressor cell factor (TisF) produced by cord blood mononuclear cells (MNC) in 48-hr, two-way mixed lymphocyte cultures (MLC). The target of this factor was a radiosensitive, T4+ (T8-) adult suppressor T cell subset. The cellular origin of this TisF was examined in the present study. IgG production by pokeweed mitogen (PWM)-stimulated adult MNC was used as an assay for TisF activity. It was found that TisF-producing cells formed rosettes with sheep erythrocytes (E+) and were independent of adherent cells (AC) in the production of TisF. They were resistant to irradiation (2500 rads) and phenotypic characterization with T cell reactive monoclonal antibodies indicated that they resided in the T8- (T4+) population. Furthermore, both TQ1- and TQ1+ cells were required for the production of TisF activity and such activity could not be reconstituted by supernatants from TQ1- MLC and TQ1+ MLC. These results indicate that the production of TisF is dependent upon interactions between radioresistant E+, T8-, TQ1- and radioresistant E+, T8-, TQ1+ cells

A production model and maintenance planning model for the process industry

NARCIS (Netherlands)

Ashayeri, J.; Teelen, A.; Selen, W.J.

1995-01-01

In this paper a model is developed to simultaneously plan preventive maintenance and production in a process industry environment, where maintenance planning is extremely important. The model schedules production jobs and preventive maintenance jobs, while minimizing costs associated with

Production planning and scheduling in refinery industry

International Nuclear Information System (INIS)

Persson, Jan.

1999-01-01

In this thesis we consider production planning and scheduling in refinery industry, in particular we study the planning and scheduling at the Nynaes AB refinery and at the Scanraff AB refinery. The purpose is to contribute to the development and the use of optimization models to support efficient decision making. We identify various decision problems concerning the aggregated production planning, the shipment planning, the scheduling of operation modes, and the utilization of pipes and tanks; and we discuss the potential to successfully apply optimization models on these problems. We formulate a mixed integer linear programming model for the scheduling of operation modes at Nynaes. The model concerns decisions about which mode of operation to use at a particular point in time in order to minimize costs of changing modes and costs of keeping inventories, given demands for products. We derive several types of valid inequalities for this mathematical problem and show how these inequalities can improve the lower bound obtained from the linear programming relaxation of the problem. We also show how the valid inequalities can be used to improve the performance of a branch and bound solution approach. Further, a tabu search heuristic is developed for the scheduling problem. The solution methods are tested on data provided by the Nynaes refinery, and the performance of the methods are discussed. We present several extensions of the proposed model, and illustrate how the model can be used to support both operational and strategic decision making at the refinery. 66 refs, 6 figs, 32 tabs. Also published as: Dissertation from the International Graduate School of Management and Industrial Engineering, No 25, Licenciate Thesis

Production planning and scheduling in refinery industry

Energy Technology Data Exchange (ETDEWEB)

Persson, Jan

1999-07-01

In this thesis we consider production planning and scheduling in refinery industry, in particular we study the planning and scheduling at the Nynaes AB refinery and at the Scanraff AB refinery. The purpose is to contribute to the development and the use of optimization models to support efficient decision making. We identify various decision problems concerning the aggregated production planning, the shipment planning, the scheduling of operation modes, and the utilization of pipes and tanks; and we discuss the potential to successfully apply optimization models on these problems. We formulate a mixed integer linear programming model for the scheduling of operation modes at Nynaes. The model concerns decisions about which mode of operation to use at a particular point in time in order to minimize costs of changing modes and costs of keeping inventories, given demands for products. We derive several types of valid inequalities for this mathematical problem and show how these inequalities can improve the lower bound obtained from the linear programming relaxation of the problem. We also show how the valid inequalities can be used to improve the performance of a branch and bound solution approach. Further, a tabu search heuristic is developed for the scheduling problem. The solution methods are tested on data provided by the Nynaes refinery, and the performance of the methods are discussed. We present several extensions of the proposed model, and illustrate how the model can be used to support both operational and strategic decision making at the refinery. 66 refs, 6 figs, 32 tabs. Also published as: Dissertation from the International Graduate School of Management and Industrial Engineering, No 25, Licenciate Thesis.

Production planning and scheduling in refinery industry

Energy Technology Data Exchange (ETDEWEB)

Persson, Jan

1999-06-01

In this thesis we consider production planning and scheduling in refinery industry, in particular we study the planning and scheduling at the Nynaes AB refinery and at the Scanraff AB refinery. The purpose is to contribute to the development and the use of optimization models to support efficient decision making. We identify various decision problems concerning the aggregated production planning, the shipment planning, the scheduling of operation modes, and the utilization of pipes and tanks; and we discuss the potential to successfully apply optimization models on these problems. We formulate a mixed integer linear programming model for the scheduling of operation modes at Nynaes. The model concerns decisions about which mode of operation to use at a particular point in time in order to minimize costs of changing modes and costs of keeping inventories, given demands for products. We derive several types of valid inequalities for this mathematical problem and show how these inequalities can improve the lower bound obtained from the linear programming relaxation of the problem. We also show how the valid inequalities can be used to improve the performance of a branch and bound solution approach. Further, a tabu search heuristic is developed for the scheduling problem. The solution methods are tested on data provided by the Nynaes refinery, and the performance of the methods are discussed. We present several extensions of the proposed model, and illustrate how the model can be used to support both operational and strategic decision making at the refinery. 66 refs, 6 figs, 32 tabs. Also published as: Dissertation from the International Graduate School of Management and Industrial Engineering, No 25, Licenciate Thesis

The design of system for operative planning of blast furnace production process

Directory of Open Access Journals (Sweden)

Malindžák Dušan

1996-12-01

Full Text Available A system for operative planning of blast furnace production process is described in the paper. The suggested system is based on the use of a new hierarchy of operative plans, consisting of one-month plan, (7+3 days plan, and 24-hour plan. The system allows smoothing of production process at the blast furnace plant, and at the same time satisfies all requirements of the steel plant regarding to the amount of pig iron.

A Multiobjective Stochastic Production-Distribution Planning Problem in an Uncertain Environment Considering Risk and Workers Productivity

Directory of Open Access Journals (Sweden)

S. M. J. Mirzapour Al-e-Hashem

2011-01-01

Full Text Available A multi-objective two stage stochastic programming model is proposed to deal with a multi-period multi-product multi-site production-distribution planning problem for a midterm planning horizon. The presented model involves majority of supply chain cost parameters such as transportation cost, inventory holding cost, shortage cost, production cost. Moreover some respects as lead time, outsourcing, employment, dismissal, workers productivity and training are considered. Due to the uncertain nature of the supply chain, it is assumed that cost parameters and demand fluctuations are random variables and follow from a pre-defined probability distribution. To develop a robust stochastic model, an additional objective functions is added to the traditional production-distribution-planning problem. So, our multi-objective model includes (i the minimization of the expected total cost of supply chain, (ii the minimization of the variance of the total cost of supply chain and (iii the maximization of the workers productivity through training courses that could be held during the planning horizon. Then, the proposed model is solved applying a hybrid algorithm that is a combination of Monte Carlo sampling method, modified -constraint method and L-shaped method. Finally, a numerical example is solved to demonstrate the validity of the model as well as the efficiency of the hybrid algorithm.

Towards an integration of process planning and production planning and control for flexible manufacturing systems

NARCIS (Netherlands)

Gaalman, GJC; Slomp, J; Suresh, NC

This introduction article attempts to present some major issues relating to the integration of process planning and production planning and control (PPC) for flexible manufacturing systems (FMSs). It shows that the performance of an FMS can be significantly improved and FMS capabilities more

Feed Materials Production Center Waste Management Plan

International Nuclear Information System (INIS)

Watts, R.E.; Allen, T.; Castle, S.A.; Hopper, J.P.; Oelrich, R.L.

1986-01-01

In the process of producing uranium metal products used in Department of Energy (DOE) defense programs at other DOE facilities, various types of wastes are generated at the Feed Materials Production Center (FMPC). Process wastes, both generated and stored, are discussed in the Waste Management Plan and include low-level radioactive waste (LLW), mixed hazardous/radioactive waste, and sanitary/industrial waste. Scrap metal waste and wastes requiring special remediation are also addressed in the Plan. The Waste Management Plan identifies the comprehensive programs developed to address safe storage and disposition of all wastes from past, present, and future operations at the FMPC. Waste streams discussed in this Plan are representative of the waste generated and waste types that concern worker and public health and safety. Budgets and schedules for implementation of waste disposition are also addressed. The waste streams receiving the largest amount of funding include LLW approved for shipment by DOE/ORO to the Nevada Test Site (NTS) (MgF 2 , slag leach filter cake, and neutralized raffinate); remedial action wastes (waste pits, K-65 silo waste); thorium; scrap metal (contaminated and noncontaminated ferrous and copper scrap); construction rubble and soil generated from decontamination and decommissioning of outdated facilities; and low-level wastes that will be handled through the Low-Level Waste Processing and Shipping System (LLWPSS). Waste Management milestones are also provided. The Waste Management Plan is divided into eight major sections: Introduction; Site Waste and Waste Generating Process; Strategy; Projects and Operations; Waste Stream Budgets; Milestones; Quality Assurance for Waste Management; and Environmental Monitoring Program

Multi-Objective Fuzzy Linear Programming In Agricultural Production Planning

Directory of Open Access Journals (Sweden)

H.M.I.U. Herath

2015-08-01

Full Text Available Abstract Modern agriculture is characterized by a series of conflicting optimization criteria that obstruct the decision-making process in the planning of agricultural production. Such criteria are usually net profit total cost total production etc. At the same time the decision making process in the agricultural production planning is often conducted with data that accidentally occur in nature or that are fuzzy not deterministic. Such data are the yields of various crops the prices of products and raw materials demand for the product the available quantities of production factors such as water labor etc. In this paper a fuzzy multi-criteria mathematical programming model is presented. This model is applied in a region of 10 districts in Sri Lanka where paddy is cultivated under irrigated and rain fed water in the two main seasons called Yala and Maha and the optimal production plan is achieved. This study was undertaken to find out the optimal allocation of land for paddy to get a better yield while satisfying the two conflicting objectives profit maximizing and cost minimizing subjected to the utilizing of water constraint and the demand constraint. Only the availability of land constraint is considered as a crisp in nature while objectives and other constraints are treated as fuzzy. It is observed that the MOFLP is an effective method to handle more than a single objective occurs in an uncertain vague environment.

Stochastic Optimization in The Power Management of Bottled Water Production Planning

Science.gov (United States)

Antoro, Budi; Nababan, Esther; Mawengkang, Herman

2018-01-01

This paper review a model developed to minimize production costs on bottled water production planning through stochastic optimization. As we know, that planning a management means to achieve the goal that have been applied, since each management level in the organization need a planning activities. The built models is a two-stage stochastic models that aims to minimize the cost on production of bottled water by observing that during the production process, neither interfernce nor vice versa occurs. The models were develop to minimaze production cost, assuming the availability of packing raw materials used considered to meet for each kind of bottles. The minimum cost for each kind production of bottled water are expressed in the expectation of each production with a scenario probability. The probability of uncertainly is a representation of the number of productions and the timing of power supply interruption. This is to ensure that the number of interruption that occur does not exceed the limit of the contract agreement that has been made by the company with power suppliers.

Family Violence and the Need for Prevention Research in First Nations, Inuit, and Métis Communities1

Science.gov (United States)

Andersson, Neil; Nahwegahbow, Amy

2010-01-01

Existing sources produce widely varying estimates of family violence in First Nations, Inuit, and Métis communities; taken together, they imply a convincing if poorly quantified higher risk of family violence in Aboriginal communities, with the greater burden borne by women. With the accelerating HIV epidemic in some Aboriginal communities, prevention of domestic violence takes on even greater urgency. Five planks in a prevention research platform include: training emerging researchers from all Aboriginal groups to promote culturally specific research; systematic review of unpublished and published knowledge of interventions that reduce domestic violence; intervention theory development specific to each community; attention to the particular ethical issues; and methods development focused on interventions. PMID:20975851

Enhanced Simulated Annealing for Solving Aggregate Production Planning

Directory of Open Access Journals (Sweden)

Mohd Rizam Abu Bakar

2016-01-01

Full Text Available Simulated annealing (SA has been an effective means that can address difficulties related to optimisation problems. SA is now a common discipline for research with several productive applications such as production planning. Due to the fact that aggregate production planning (APP is one of the most considerable problems in production planning, in this paper, we present multiobjective linear programming model for APP and optimised by SA. During the course of optimising for the APP problem, it uncovered that the capability of SA was inadequate and its performance was substandard, particularly for a sizable controlled APP problem with many decision variables and plenty of constraints. Since this algorithm works sequentially then the current state will generate only one in next state that will make the search slower and the drawback is that the search may fall in local minimum which represents the best solution in only part of the solution space. In order to enhance its performance and alleviate the deficiencies in the problem solving, a modified SA (MSA is proposed. We attempt to augment the search space by starting with N+1 solutions, instead of one solution. To analyse and investigate the operations of the MSA with the standard SA and harmony search (HS, the real performance of an industrial company and simulation are made for evaluation. The results show that, compared to SA and HS, MSA offers better quality solutions with regard to convergence and accuracy.

A Predictive Model of Multi-Stage Production Planning for Fixed Time Orders

Directory of Open Access Journals (Sweden)

Kozłowski Edward

2014-09-01

Full Text Available The traditional production planning model based upon a deterministic approach is well described in the literature. Due to the uncertain nature of manufacturing processes, such model can however incorrectly represent actual situations on the shop floor. This study develops a mathematical modeling framework for generating production plans in a multistage manufacturing process. The devised model takes into account the stochastic model for predicting the occurrence of faulty products. The aim of the control model is to determine the number of products which should be manufactured in each planning period to minimize both manufacturing costs and potential financial penalties for failing to fulfill the order completely.

New Production Reactor project-management plan

International Nuclear Information System (INIS)

McCrosson, F.J.; Hibbard, L.; Buckner, M.R.

1982-01-01

This document provides a project management plan for the first phase of a project to design and build a new production reactor (NPR) at SRP. The design of the NPR is based upon proven SRP heavy water reactor design, with several enhancements such as full containment, moderator detritiation, improved cooling, and modernized control rooms and instrumentation. The first phase of the NPR project includes environmental and safety analyses, preparation of the technical data summary and basic data, site studies, engineering studies, and conceptual design. The project management plan was developed by a 14-member task force comprised of representatives from the Technical Division, the Manufacturing Division, the Departmental Engineer's Office, and the Engineering Department

A continuous-time control model on production planning network ...

African Journals Online (AJOL)

A continuous-time control model on production planning network. DEA Omorogbe, MIU Okunsebor. Abstract. In this paper, we give a slightly detailed review of Graves and Hollywood model on constant inventory tactical planning model for a job shop. The limitations of this model are pointed out and a continuous time ...

Study on DSM-based task planning of product cooperative development

Institute of Scientific and Technical Information of China (English)

无

2008-01-01

The results of analyzing the managerial characteristics and complexity of product cooperative development suggest that task planning is an important aspect for process management of product cooperative development and the method for planning tasks should be able to model the dependency between tasks and iterations during the development process. In this paper, a DSM-based method and its corresponding optimization algorithms are developed. At first the coupled task sets and uncoupled task sets are identified...

Developing and promoting OKP production system: a JIT production planning approach

Science.gov (United States)

Samavati, Mehran

2011-10-01

The role of production in competitive system of market on one hand and the changing conditions of market on the other hand has caused the need for more developed planning in such environments. The general purpose of the present research is to realize One-of- a- Kind- Product model (OKP) that is developed in two stages. In OKP model presented in 1994 only one sample of each product is produced and only one production method is considered for each product. In order to make OKP model more real and to use it in promoting more production methods, the following developments were made in this research: 1-First Development: Considering various methods for producing each product. 2-Second Development: Producing more than one sample of each product, while considering various production methods for each product. These models promoted OKP model of 1994. They can be used in more diversified production methods in order to promote them. In present model, while describing the main OKP model new models are provided as well. The significance of OKP has been described in Introduction

A systematic review of the effectiveness of school-based obesity prevention programmes for First Nations, Inuit and Métis youth in Canada.

Science.gov (United States)

Godin, K; Leatherdale, S T; Elton-Marshall, T

2015-06-01

First Nations, Inuit and Métis (FNIM) youth are disproportionately affected by obesity and represent known a high-risk group in Canada. School-based prevention programmes may have the potential to effectively influence obesity-related health behaviours (i.e. healthy eating and physical activity) among this population. We conducted a systematic review of nine electronic databases (2003-2014) to identify studies that describe school-based programmes that have been developed to improve obesity-related health behaviours and outcomes among FNIM youth in Canada. The objectives of this review were to identify and evaluate the effectiveness of these programmes and assess the strength of the methodologies used to evaluate them. Fifteen studies, representing seven distinct interventions, met our inclusion criteria. The majority of these programmes did not result in significant improvements in outcomes related to obesity, healthy eating, or physical activity among FNIM youth. The studies varied in design rigour and use of evaluation activities. The lack of literature on effective school-based programmes for FNIM youth in Canada that target obesity-related outcomes highlights a priority area for future intervention development, evaluation and dissemination within the peer-reviewed literature. Further research is needed on interventions involving Métis and Inuit youth, secondary school-aged FNIM youth and FNIM youth living in urban settings. © 2015 World Obesity.

Structuring front-end innovation activities throughout strategic product planning

Directory of Open Access Journals (Sweden)

Thaisa Rodrigues

Full Text Available Abstract Strategic product planning (SPP for new product development (NPD in the front-end of innovation (FEI is a great challenge for managers and practitioners. This article analyzes the structuring process of FEI activities during SPP. A research was carried out with 78 industries from both food and furniture in Brazil. Our study revealed that FEI activities are structured in an intricate network with a high level of complexity and interdependence. The large amount of activities and the complexity in structuring them denote that companies are concerned to reduce uncertainties and risks intensifying the planning phase.

Leadership and productivity in planning organizations: a case study.

Science.gov (United States)

Whitcomb, G R; Williams, E G

1978-01-01

This paper presents the findings of a case study dealing mainly with the effects of two divergent leadership styles on the productivity of a planning organization. Changes in various kinds of participation in the agency's activities--an important side effect--are also linked to the two leadership patterns. The agency studied, a private health and welfare council in a medium-sized American city, varied considerably in its output of planning activities and decision making depending on whether it had a participative or a directive leader. The results indicated that there was a trade-off between such highly revered social values as leadership and the extent of participation by staff, board members, and local agency administrators. Implications focus on ways to achieve diversity in communication style among managers and the role of productivity measures in determining the overall effectiveness of planning agencies.

Production and Distribution Planning in District Heating Systems; Produktions- och distributionsplanering av fjaerrvaerme

Energy Technology Data Exchange (ETDEWEB)

Kvarnstroem, Johan; Dotzauer, Erik; Dahlquist, Erik

2006-12-15

To produce heat and power is costly. Therefore it is important for the district heating companies to plan and optimize the production. The aim with the present project is to find out how also the distribution of heat can be considered in the planning. The principal procedure is to first construct a prediction of the heat demand, and then, given the demand prediction, construct the production plan. Due to the complexity of the problem, the need for mathematical models is obvious. The report gives a survey introduction to production planning in district heating systems and presents a model for the purpose. The model is developed for one of the district heating systems in Stockholm owned by the energy company Fortum. Traditionally, models for production planning do not consider the distribution network. In such models, usually the methodology Mixed Integer Programming (MIP) is used. The report suggests how the distribution network can be modeled as a MIP; it shall be possible to link the network model to existing software that models the production plants as MIP. The model is developed in the programming language GAMS. Analysis and results are presented. The results show that the suggested plans vary depending on if the distribution network is considered or not. The report also suggests how a simple sensitivity analysis of the production plans can be performed. This is necessary since there are always uncertainties associated with weather- and load predictions.

Crop succession requirements in agricultural production planning

NARCIS (Netherlands)

Klein Haneveld, W.K.; Stegeman, A.

2005-01-01

A method is proposed to write crop succession requirements as linear constraints in an LP-based model for agricultural production planning. Crop succession information is given in the form of a set of inadmissible successions of crops. The decision variables represent the areas where a certain

Home-based radiology transcription and a productivity pay plan.

Science.gov (United States)

Kerr, K

1997-01-01

Shands Hospital in Gainesville, Fla., decided to evaluate the way it provided transcription services in its radiology department. It identified four goals: increased productivity, decreased operating expense, finding much needed space in the radiology department and increasing employee morale. The department performs 165,000 procedures annually, with 66 radiologists, 29 faculty, and 37 residents and fellows on staff. Six FTEs comprised the transcription pool in the radiology department, with transcription their only duty. Transcriptionists were paid an hourly rate based on their years of service, not their productivity. Evaluation and measurement studies were undertaken by the hospital's management systems engineering department. The transcriptionists' hours were then changed to provide coverage during the periods of heaviest dictation. The productivity level of the transcription staff was also measured and various methods of measurement reviewed. The goal was a pure incentive pay plan that would reward employees for every increase in productivity. The incentive pay plan was phased in over a three-month period. Transcriptionists were paid for work performed, with no base pay beyond minimum wage. The move to home-based transcription was planned. The necessary equipment was identified and various issues specific to working at home were addressed. Approximately six months later, the transcriptionists were set up to work at home. The astounding results achieved are presented: 28% increase in productivity, operational cost savings exceeding $25,000 and a space savings of 238 square feet.

Application of mathematical planning in production of filled emulsion rubbers

Science.gov (United States)

Pugacheva, I. N.; Molokanova, L. V.; Popova, L. V.; Repin, P. S.

2018-05-01

The applicability of mathematical planning of experiment in the field of chemistry and chemical engineering, in particular in the industrial production of synthetic rubbers, is considered in the article. Possibility of using secondary material resources, which are waste products of light industry, in the production of elastomeric compositions is studied. The method of obtaining a powdered cellulose additive from wastes containing cellulose fiber is described. The best way of introducing the obtained additive into elastomeric compositions based on the emulsion rubber is established. Optimal conditions for obtaining filled emulsion rubber with the help of a powdered cellulose additive were established basing on the mathematical planning of experiment.

15 CFR 713.4 - Advance declaration requirements for additionally planned production, processing, or consumption...

Science.gov (United States)

2010-01-01

... additionally planned production, processing, or consumption of Schedule 2 chemicals. 713.4 Section 713.4..., processing, or consumption of Schedule 2 chemicals. (a) Declaration requirements for additionally planned activities. (1) You must declare additionally planned production, processing, or consumption of Schedule 2...

Study on DSM-based task planning of product cooperative development

Institute of Scientific and Technical Information of China (English)

Jiang Zengqiang; Liu Mingzhou; Zhao Han; Ge Maogen; Guo Jia

2008-01-01

The results of analyzing the managerial characteristics and complexity of product cooperative development suggest that task planning is an important aspect for process management of product cooperative development and the method for planning tasks should be able to model the dependency between tasks and iterations during the development process. In this paper, a DSM-based method and its corresponding optimization algorithms are developed. At first the coupled task sets and uncoupled task sets are identified, and the tasks are then optimized by the corresponding algorithms. The optimal tasks plan will reduce the development time and cost. Considering the practical requirements in real world, a Multilayer DSM is proposed, and its information communication techniques between DSM and traversing principle are described in details.

Electricity derivative markets: Investment valuation, production planning and hedging

International Nuclear Information System (INIS)

Naesaekkaelae, E.

2005-01-01

This thesis studies electricity derivative markets from a view point of an electricity producer. The traditionally used asset pricing methods, based on the no arbitrage principle, are extended to take into account electricity specific features: the non storability of electricity and the variability in the load process. The sources of uncertainty include electricity forward curve, prices of resources used to generate electricity, and the size of the future production. Also the effects of competitors' actions are considered. The thesis illustrates how the information in the derivative prices can be used in investment and production planning. In addition, the use of derivatives as a tool to stabilize electricity dependent cash flows is considered. The results indicate that the information about future electricity prices and their uncertainty, obtained from derivative markets, is important in investment analysis and production planning. (orig.)

Electricity derivative markets: Investment valuation, production planning and hedging

Energy Technology Data Exchange (ETDEWEB)

Naesaekkaelae, E.

2005-07-01

This thesis studies electricity derivative markets from a view point of an electricity producer. The traditionally used asset pricing methods, based on the no arbitrage principle, are extended to take into account electricity specific features: the non storability of electricity and the variability in the load process. The sources of uncertainty include electricity forward curve, prices of resources used to generate electricity, and the size of the future production. Also the effects of competitors' actions are considered. The thesis illustrates how the information in the derivative prices can be used in investment and production planning. In addition, the use of derivatives as a tool to stabilize electricity dependent cash flows is considered. The results indicate that the information about future electricity prices and their uncertainty, obtained from derivative markets, is important in investment analysis and production planning. (orig.)

An integrated multi−period planning of the production and transportation of multiple petroleum products in a single pipeline system

Directory of Open Access Journals (Sweden)

Alberto Herrán

2011-01-01

Full Text Available A multiproduct pipeline provides an economic way to transport large volumes of refined petroleum products over long distances. In such a pipeline, different products are pumped back−to−back without any separation device between them. The sequence and lengths of such pumping runs must be carefully selected in order to meet market demands while minimizing pipeline operational costs and satisfying several constraints. The production planning and scheduling of the products at the refinery must also be synchronized with the transportation in order to avoid the usage of the system at some peak−hour time intervals. In this paper, we propose a multi−period mixed integer nonlinear programming (MINLP model for an optimal planning and scheduling of the production and transportation of multiple petroleum products from a refinery plant connected to several depots through a single pipeline system. The objective of this work is to generalize the mixed integer linear programming (MILP formulation proposed by Cafaro and Cerdá (2004, Computers and Chemical Engineering where only a single planning period was considered and the production planning and scheduling was not part of the decision process. Numerical examples show how the use of a single period model for a given time period may lead to infeasible solutions when it is used for the upcoming periods. These examples also show how integrating production planning with the transportation and the use of a multi−period model may result in a cost saving compared to using a single−period model for each period, independently.

Optimized production planning model for a multi-plant cultivation system under uncertainty

Science.gov (United States)

Ke, Shunkui; Guo, Doudou; Niu, Qingliang; Huang, Danfeng

2015-02-01

An inexact multi-constraint programming model under uncertainty was developed by incorporating a production plan algorithm into the crop production optimization framework under the multi-plant collaborative cultivation system. In the production plan, orders from the customers are assigned to a suitable plant under the constraints of plant capabilities and uncertainty parameters to maximize profit and achieve customer satisfaction. The developed model and solution method were applied to a case study of a multi-plant collaborative cultivation system to verify its applicability. As determined in the case analysis involving different orders from customers, the period of plant production planning and the interval between orders can significantly affect system benefits. Through the analysis of uncertain parameters, reliable and practical decisions can be generated using the suggested model of a multi-plant collaborative cultivation system.

Layout Optimization Model for the Production Planning of Precast Concrete Building Components

Directory of Open Access Journals (Sweden)

Dong Wang

2018-05-01

Full Text Available Precast concrete comprises the basic components of modular buildings. The efficiency of precast concrete building component production directly impacts the construction time and cost. In the processes of precast component production, mold setting has a significant influence on the production efficiency and cost, as well as reducing the resource consumption. However, the development of mold setting plans is left to the experience of production staff, with outcomes dependent on the quality of human skill and experience available. This can result in sub-optimal production efficiencies and resource wastage. Accordingly, in order to improve the efficiency of precast component production, this paper proposes an optimization model able to maximize the average utilization rate of pallets used during the molding process. The constraints considered were the order demand, the size of the pallet, layout methods, and the positional relationship of components. A heuristic algorithm was used to identify optimization solutions provided by the model. Through empirical analysis, and as exemplified in the case study, this research is significant in offering a prefabrication production planning model which improves pallet utilization rates, shortens component production time, reduces production costs, and improves the resource utilization. The results clearly demonstrate that the proposed method can facilitate the precast production plan providing strong practical implications for production planners.

Procedural issues in the development of a production plan in the petroleum transport computerized system of plan projects

Energy Technology Data Exchange (ETDEWEB)

German, V T; Karlikov, Y P; Papeev, V M; Samorodkin, V D; Vasil' ev, Y I

1980-01-01

The process of planning petroleum transportation must be described by a model that may be used to vary the distribution of the volumes of oil transported and to organize the oil flows so as to satisfy users requiring a particular volume of unprocessed petroleum. By means of the studies performed here, a number of conclusions may be drawn: 1. Available algorithms make it possible to compute the detailed network-wide indicators for petroleum transportation in the annual planning model; determine the capacities needed for individual members of the network; and create the necessary list of output documents for compliation of the tenative plan of production for oil transport; 2. An implementation of the oil transport plan using the specified route method should be based on an heuristic approach (a route is specified by a specialist or the routes of the current year are used), thereby allowing us to obtain the necessary production plans.

Refinery production planning and scheduling: the refining core business

Directory of Open Access Journals (Sweden)

M. Joly

2012-06-01

Full Text Available Intelligent production planning and scheduling are of paramount importance to ensure refinery profitability, logistic reliability and safety at the local and corporate levels. In Brazil, such activities play a particularly critical role, since the Brazilian downstream model is moving towards a demand-driven model rather than a supply-driven one. Moreover, new and specialized non-linear constraints are continuously being incorporated into these large-scale problems: increases in oil prices implying the need for processing poor quality crudes, increasing demand and new demand patterns for petroleum products, new stringent environmental regulations related to clean fuels and start-up of new production technologies embedded into more complex refining schemes. This paper aims at clarifying the central role of refinery planning and scheduling activities in the Petrobras refining business. Major past and present results are outlined and corporate long-term strategies to deal with present and future challenges are presented.

Generation and energy utilization of methane form industrial wastewater; Produccion y aprovechamiento energetico de metano a partir de agua residual industrial

Energy Technology Data Exchange (ETDEWEB)

Lebek, M.

2009-07-01

At the production site of a natural ingredients manufacturer for the food industry was necessary the adjustment of the WWTP to the enlargement of the production and its complement with a pre-treatment. The core of the treatment plan tis an UASB (Upflow Anaerobic Sludge Blanket) reactor where the wastewater is removed under anaerobic conditions. The main advantages of this treatment ar the operation stability and the high methane production. The biogas generated is cleaned before it is used during the production process as an energy resource. (Author)

Generation and energy utilization of methane form industrial wastewater

International Nuclear Information System (INIS)

Lebek, M.

2009-01-01

At the production site of a natural ingredients manufacturer for the food industry was necessary the adjustment of the WWTP to the enlargement of the production and its complement with a pre-treatment. The core of the treatment plan tis an UASB (Upflow Anaerobic Sludge Blanket) reactor where the wastewater is removed under anaerobic conditions. The main advantages of this treatment ar the operation stability and the high methane production. The biogas generated is cleaned before it is used during the production process as an energy resource. (Author)

Uveítis intermedia: Experiencias terapéuticas Intermediate uveitis: Therapeutic experiences

Directory of Open Access Journals (Sweden)

Sandra M. Borges Pérez

2001-12-01

Full Text Available Se realizó un estudio descriptivo prospectivo a 50 ojos (41 pacientes con el diagnóstico de uveítis intermedia durante un período de 3 años. Esta patología fue más frecuente en la mujer (58 %, en edades jóvenes (25 a 45 años y en plena actividad laboral. Se presentan complicaciones y dentro de ellas el edema macular cistoide constituye la causa que más afecta la visión. La mejoría de la agudeza visual fue más notable en los pacientes bajo régimen de tratamiento médico acompañado de tratamiento quirúrgico (40 %. El 50 % de los pacientes presentaron recidivas.A descriptive and prospective study of 50 eyes (41 patients with the diagnosis of intermediate uveitis was conducted during 3 years. This pathology was more frequent in women (58 %, in young patients (25-45 years old and among workers. Among the complications, the cystoid macular edema was the main cause of vision affections. The improvement of visual acuity was more remarkable in patients under medical and surgical treatment (40 %. 50 % of the patients had relapses.

Production and planning organization at coal mines. Organizatsiya proizvodstva i planirovanie na ugol'nykh shakhtakh

Energy Technology Data Exchange (ETDEWEB)

Rybnikov, S E; Voloshin, A P

1981-01-01

A discussion is made of problems concerning the organization of production, labor, and planning at enterprises of the coal industry. Theoretical and methodological principles are given for production organization, standardization and renumeration of wages, production planning and the use of available capacity. Computations are given for optimal numbers of workers, the essential growth in productivity, material expenditures for coal recovery, lowering production costs, and increasing the profitability of enterprise operations. Particular attention is given to the operation of mines of production and associations, organizational and practical problems concerned with the technical retooling of coal mines, and improving management and planning. The teaching aid is intended for students at coal technical institutes specializing in planning at enterprises of the coal industry. 14 references, 26 figures, 14 tables.

Medium range production planning of "Tacer" company: a case study

OpenAIRE

Süer, Burak

1994-01-01

Ankara : Department of Management and the Graduate School of Business Administration of Bilkent University, 1994. Thesis (Master's) -- Bilkent University, 1994 Includes bibliographical references. In order to foresee the potential problems related with production, a production plan is undertaken for the year 1994. Product classification is determined according to the annual sales volume of the company "Tacer". A production schedule is prepared in relation with the forecast d...

Integrated production-distribution planning optimization models: A review in collaborative networks context

Directory of Open Access Journals (Sweden)

Beatriz Andres

2017-01-01

Full Text Available Researchers in the area of collaborative networks are more and more aware of proposing collaborative approaches to address planning processes, due to the advantages associated when enterprises perform integrated planning models. Collaborative production-distribution planning, among the supply network actors, is considered a proper mechanism to support enterprises on dealing with uncertainties and dynamicity associated to the current markets. Enterprises, and especially SMEs, should be able to overcome the continuous changes of the market by increasing their agility. Carrying out collaborative planning allows enterprises to enhance their readiness and agility for facing the market turbulences. However, SMEs have limited access when incorporating optimization tools to deal with collaborative planning, reducing their ability to respond to the competition. The problem to solve is to provide SMEs affordable solutions to support collaborative planning. In this regard, new optimisation algorithms are required in order to improve the collaboration within the supply network partners. As part of the H2020 Cloud Collaborative Manufacturing Networks (C2NET research project, this paper presents a study on integrated production and distribution plans. The main objective of the research is to identify gaps in current optimization models, proposed to address integrated planning, taking into account the requirements and needs of the industry. Thus, the needs of the companies belonging to the industrial pilots, defined in the C2NET project, are identified; analysing how these needs are covered by the optimization models proposed in the literature, to deal with the integrated production-distribution planning.

Working memory and planning during sentence production.

Science.gov (United States)

Martin, Randi C; Yan, Hao; Schnur, Tatiana T

2014-10-01

Speakers retrieve conceptual, syntactic and lexical information in advance of articulation during sentence production. What type of working memory (WM) store is used to hold the planned information before speaking? To address this question, we measured onset latencies when subjects produced sentences that began with either a complex or a simple initial noun phrase, while holding semantic, phonological or spatial information in WM. Although we found that subjects had longer onset latencies for sentences beginning with a complex noun phrase, showing a phrasal scope of planning, the magnitude of this complexity effect was not affected by any type of WM load. However, subjects made more syntactic errors (but not lexical errors) for sentences beginning with a complex noun phrase, suggesting that advance planning for these phrases occurs at a syntactic rather than lexical-semantic level, which may account for the lack of effect with various types of WM load in the current study. Copyright © 2014 Elsevier B.V. All rights reserved.

Slovenske elektrarne has fulfilled the plan of electric power production at 101 %

International Nuclear Information System (INIS)

Anon

2004-01-01

Slovenske elektrarne, a. s., produced in 2003 year the electric power in capacity 26,047.6 GWh, whereby they fulfilled business plan at 101 %. In compare with the last year it is a reduction in production by 1,397.3 GWh. The biggest share of production - till 68.6 % of overall production of the Slovenske elektrarne, was provided by nuclear sources. Nuclear power plants fulfilled business plan at 104 %, when Jaslovske Bohunice NPP has produced 11,625 GWh and Mochovce NPP 6,238 GWh. The share of other power plants on the electricity production is presented

Impact of Close and Positive Margins in Transoral Laser Microsurgery for Tis-T2 Glottic Cancer.

Science.gov (United States)

Fiz, Ivana; Mazzola, Francesco; Fiz, Francesco; Marchi, Filippo; Filauro, Marta; Paderno, Alberto; Parrinello, Giampiero; Piazza, Cesare; Peretti, Giorgio

2017-01-01

Transoral laser microsurgery (TLM) represents one of the most effective treatment strategies for Tis-T2 glottic squamous cell carcinomas (SCC). The prognostic influence of close/positive margins is still debated, and the role of narrow band imaging (NBI) in their intraoperative definition is still to be validated on large cohort of patients. This study analyzed the influence of margin status on recurrence-free survival (RFS) and disease-specific survival (DSS). We retrospectively studied 507 cases of pTis-T1b (Group A) and 127 cases of pT2 (Group B) glottic SCC. We identified the following margin status: negative ( n  = 232), close superficial ( n  = 79), close deep (CD) ( n  = 35), positive single superficial ( n  = 146), positive multiple superficial ( n  = 94), and positive deep ( n  = 48) and analyzed their impact on RFS and DSS. Close margins were defined by tumor-margin distance <1 mm. Pre-TLM margins were defined by white light in 323 patients, whereas NBI was employed in 311 patients. In Group A, DSS and RFS were reduced in positive multiple superficial and positive deep margins (DSS = 96.1 and 97%, both p  < 0.05; RFS = 72%, p  < 0.001 and 75.8%, p  < 0.01). In Group B, DSS was reduced in positive multiple superficial margins (82.4%, p  < 0.05). RFS was reduced in positive single superficial, positive multiple superficial, and positive deep margins (62.5, 41.2, and 53.3%, p  < 0.01). In the entire population, RFS was reduced in CD margins (77.1%, p  < 0.05). Use of NBI led to improvement in RFS and DSS. The study indicates that close and positive single superficial margins do not affect DSS. By contrast, all types of margin positivity predict the occurrence of relapses, albeit with different likelihood, depending on stage/margin type. CD margins should be considered as a single risk factor. Use of NBI granted better intraoperative margins definition.

Productivity Research and Development Planning Workshop.

Science.gov (United States)

1986-03-01

mission. These ideas must come from everyone in all echelons of the Comand. The MAC quality of worklife efforts consist of quality circles, labor-manage...that would not have been captured by the measure as initially formulated by the PIG. The balance of the plan and recommenda- tions made by the PMWG...people are doing things. We have the suggestion program, the quality of worklife program, and the Tech Mod program. All of these programs are productivity

Planning in Sentence Production: Evidence for the Phrase as a Default Planning Scope

Science.gov (United States)

Martin, Randi C.; Crowther, Jason E.; Knight, Meredith; Tamborello, Franklin P., II; Yang, Chin-Lung

2010-01-01

Controversy remains as to the scope of advanced planning in language production. Smith and Wheeldon (1999) found significantly longer onset latencies when subjects described moving-picture displays by producing sentences beginning with a complex noun phrase than for matched sentences beginning with a simple noun phrase. While these findings are…

Marketing a managed care plan: achieving product differentiation.

Science.gov (United States)

Romeo, N C

1996-01-01

The health care marketplace is changing dramatically, even without federal reform measures. This is a volatile, yet promising, time to market a managed care plan. Before marketing the product, it is critical that the competition is thoroughly evaluated and consumer and employer needs are researched. The final product should be distinguishable from the competition and address market needs. Promotion can then begin, utilizing a proactive public relations and advertising campaign in addition to traditional methods of marketing.

Planning at the Phonological Level during Sentence Production

Science.gov (United States)

Schnur, Tatiana T.; Costa, Albert; Caramazza, Alfonso

2006-01-01

In two picture-word interference experiments we examined whether phrase boundaries affected how far in advance speakers plan the sounds of words during sentence production. Participants produced sentences of varying lengths (short determiner + noun + verb or long determiner + adjective + noun + verb) while ignoring phonologically related and…

Planning of optimum production from a natural gas field

Energy Technology Data Exchange (ETDEWEB)

Van Dam, J

1968-03-01

The design of an optimum development plan for a natural gas field always depends on the typical characteristics of the producing field, as well as those of the market to be served by this field. Therefore, a good knowledge of the field parameters, such as the total natural gas reserves, the well productivity, and the dependence of production rates on pipeline pressure and depletion of natural gas reserves, is required prior to designing the development scheme of the field, which in fact depends on the gas-sales contract to be concluded in order to commit the natural gas reserves to the market. In this paper these various technical parameters are discussed in some detail, and on this basis a theoretical/economical analysis of natural gas production is given. For this purpose a simplified economical/mathematical model for the field is proposed, from which optimum production rates at various future dates can be calculated. The results of these calculations are represented in a dimensionless diagram which may serve as an aid in designing optimum development plans for a natural gas field. The use of these graphs is illustrated in a few examples.

Optimal Control Approaches to the Aggregate Production Planning Problem

Directory of Open Access Journals (Sweden)

Yasser A. Davizón

2015-12-01

Full Text Available In the area of production planning and control, the aggregate production planning (APP problem represents a great challenge for decision makers in production-inventory systems. Tradeoff between inventory-capacity is known as the APP problem. To address it, static and dynamic models have been proposed, which in general have several shortcomings. It is the premise of this paper that the main drawback of these proposals is, that they do not take into account the dynamic nature of the APP. For this reason, we propose the use of an Optimal Control (OC formulation via the approach of energy-based and Hamiltonian-present value. The main contribution of this paper is the mathematical model which integrates a second order dynamical system coupled with a first order system, incorporating production rate, inventory level, and capacity as well with the associated cost by work force in the same formulation. Also, a novel result in relation with the Hamiltonian-present value in the OC formulation is that it reduces the inventory level compared with the pure energy based approach for APP. A set of simulations are provided which verifies the theoretical contribution of this work.

UTILIZING SYNTHETIC VISIBLE SPECTRA TO EXPLORE THE PHYSICAL BASIS FOR THE CLASSIFICATION OF LAMBDA BOÖTIS STARS

Energy Technology Data Exchange (ETDEWEB)

Cheng, Kwang-Ping; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A. [California State University, Fullerton CA (United States); Neff, James E. [College of Charleston, Charleston, SC (United States); Gray, Richard O. [Appalachian State University, Boone, NC (United States); Corbally, Christopher J. [Vatican Observatory, Tucson, AZ (United States)

2017-01-01

Since the peculiar nature of Lambda Boötis was first noticed in 1943, the Lambda Boo stars have been recognized as a group of peculiar A-type stars. They are Population I dwarfs that show deficiencies of iron-peak elements (up to 2 dex), but have near-solar C, N, O, and S abundances. In a previous paper, we used both observed and synthetic ultraviolet spectra to demonstrate that the C i 1657 Å/Al ii 1671 Å equivalent width ratio can help distinguish between Lambda Boo stars and other metal-weak stars hotter than 8000 K. In this paper, using observed and synthetic visible (4000–6800 Å) spectra, we demonstrate that the C i 5052.17 Å/Mg ii 4481 Å equivalent width ratio can be used as a quantitative diagnostic for cooler Lambda Boo stars.

Some effects of integrated production planning in large-scale kitchens

DEFF Research Database (Denmark)

Engelund, Eva Høy; Friis, Alan; Jacobsen, Peter

2005-01-01

Integrated production planning in large-scale kitchens proves advantageous for increasing the overall quality of the food produced and the flexibility in terms of a diverse food supply. The aim is to increase the flexibility and the variability in the production as well as the focus on freshness ...

AVLIS Production Plant Preliminary Quality Assurance Plan and Assessment

International Nuclear Information System (INIS)

1984-01-01

This preliminary Quality Assurance Plan and Assessment establishes the Quality Assurance requirements for the AVLIS Production Plant Project. The Quality Assurance Plan defines the management approach, organization, interfaces, and controls that will be used in order to provide adequate confidence that the AVLIS Production Plant design, procurement, construction, fabrication, installation, start-up, and operation are accomplished within established goals and objectives. The Quality Assurance Program defined in this document includes a system for assessing those elements of the project whose failure would have a significant impact on safety, environment, schedule, cost, or overall plant objectives. As elements of the project are assessed, classifications are provided to establish and assure that special actions are defined which will eliminate or reduce the probability of occurrence or control the consequences of failure. 8 figures, 18 tables

A Label Correcting Algorithm for Partial Disassembly Sequences in the Production Planning for End-of-Life Products

Directory of Open Access Journals (Sweden)

Pei-Fang (Jennifer Tsai

2012-01-01

Full Text Available Remanufacturing of used products has become a strategic issue for cost-sensitive businesses. Due to the nature of uncertain supply of end-of-life (EoL products, the reverse logistic can only be sustainable with a dynamic production planning for disassembly process. This research investigates the sequencing of disassembly operations as a single-period partial disassembly optimization (SPPDO problem to minimize total disassembly cost. AND/OR graph representation is used to include all disassembly sequences of a returned product. A label correcting algorithm is proposed to find an optimal partial disassembly plan if a specific reusable subpart is retrieved from the original return. Then, a heuristic procedure that utilizes this polynomial-time algorithm is presented to solve the SPPDO problem. Numerical examples are used to demonstrate the effectiveness of this solution procedure.

Sustainability Initiatives Driving Supply Chain: Climate Governance on Beef Production System

Directory of Open Access Journals (Sweden)

Ieda Kanashiro Makiya

2015-04-01

Full Text Available Two conceptual frameworks have been analytically dominant in researching innovation dynamics in sustainability transition processes, namely technological innovation systems (TIS and the multi-level perspective (MLP. The innovation systems has been principally concerned with emerging new technologies and their potential contribution to future sustainability, whereas MLP has been more strongly oriented toward reconstructing historical processes of sectorial change. In this perspective, this study aims to analyses how global climate change and environmental pressures impact on the governance of supply chain and the ripple effects on natural resource-intensive economies. Some initiatives are taken to address regulatory issues and reconcile decision-making tools on quality assurance program on value chains. This includes a multi-level perspective (MLP as Carbon Disclosure Project (CDP and technological innovation systems (TIS as Geographic Information System (GIS used as a tracking system for monitoring sustainable practices. The paper discuss the drivers of sustainable beef production system, mainly in Legal Amazon, Brazil, and requirements from a largest retailer aligned to Brazilian public policies. This study presents three distinct strategies: (1 government and public policies to control deforestation related to beef cattle production system, (2 economic approach related to transnational supermarket chain and sustainability initiatives, (3 collective action for decision-making by multiple drivers

Effective Heuristics for Capacitated Production Planning with Multiperiod Production and Demand with Forecast Band Refinement

OpenAIRE

Philip Kaminsky; Jayashankar M. Swaminathan

2004-01-01

In this paper we extend forecast band evolution and capacitated production modelling to the multiperiod demand case. In this model, forecasts of discrete demand for any period are modelled as bands and defined by lower and upper bounds on demand, such that future forecasts lie within the current band. We develop heuristics that utilize knowledge of demand forecast evolution to make production decisions in capacitated production planning environments. In our computational study we explore the ...

Decommissioning planning and the assessment of alternatives for the Hanford production reactors

International Nuclear Information System (INIS)

Miller, C.E. Jr.; Potter, R.F.

1985-01-01

Several years ago, the US Department of Energy began assessing alternatives and planning the decommissioning of eight shut-down plutonium production reactors located on the DOE Hanford Site in Washington State. The first of these graphite-moderated, water-cooled, reactors was built and started up in 1944 as part of the World War II Manhattan Project. The last of them started up in 1955. The eight reactors each operated for 12 to 24 years, with all eight operating simultaneously for about 10 years. In the 1960's, production needs declined and the reactors were one-by-one permanently shut down, the last of them in 1971. (A ninth Hanford production reactor, N Reactor, was started up in 1963; it is still operating and is not within the scope of the decommissioning planning and alternatives assessment work reported in this paper). This paper provides an overview description of the decommissioning plan for the eight shut-down Hanford production reactors and their associated fuel storage basins. Included are descriptions of the decommissioning alternatives considered for the facilities, along with discussions of National Environmental Policy Act (NEPA) process activities applicable to the Hanford decommissioning work. The criteria used in assessing decommissioning alternatives and the assumptions used in the decommissioning planning are identified. 4 refs., 8 figs., 3 tabs

Marketing plan for Pharmacare product line in the Moscow region Case Oriola-KD

OpenAIRE

Mashkilleyson, Peter

2012-01-01

The thesis was commissioned by Oriola-KD. It deals with a marketing plan for a product line called Pharmacare. The product line will be launched in 2012 in the Moscow region in the Russian Federation. The purpose of this thesis was to acquire useful information about the Moscow market for the target company and produce a marketing plan that they can implement. The research question was how to create an effective marketing plan and what it entails. The literary review consisted of the theo...

Lexical Planning in Sentence Production Is Highly Incremental: Evidence from ERPs.

Science.gov (United States)

Zhao, Li-Ming; Yang, Yu-Fang

2016-01-01

The scope of lexical planning, which means how far ahead speakers plan lexically before they start producing an utterance, is an important issue for research into speech production, but remains highly controversial. The present research investigated this issue using the semantic blocking effect, which refers to the widely observed effects that participants take longer to say aloud the names of items in pictures when the pictures in a block of trials in an experiment depict items that belong to the same semantic category than different categories. As this effect is often interpreted as a reflection of difficulty in lexical selection, the current study took the semantic blocking effect and its associated pattern of event-related brain potentials (ERPs) as a proxy to test whether lexical planning during sentence production extends beyond the first noun when a subject noun-phrase includes two nouns, such as "The chair and the boat are both red" and "The chair above the boat is red". The results showed a semantic blocking effect both in onset latencies and in ERPs during the utterance of the first noun of these complex noun-phrases but not for the second noun. The indication, therefore, is that the lexical planning scope does not encompass this second noun-phrase. Indeed, the present findings are in line with accounts that propose radically incremental lexical planning, in which speakers plan ahead only one word at a time. This study also provides a highly novel example of using ERPs to examine the production of long utterances, and it is hoped the present demonstration of the effectiveness of this approach inspires further application of ERP techniques in this area of research.

Connected vehicle impacts on transportation planning technical memorandum #2 : connected vehicle planning processes and products and stakeholder roles and responsibilities.

Science.gov (United States)

2015-01-01

The objective of this project, Connected Vehicle Impacts on Transportation Planning, is to comprehensively assess how connected vehicles should : be considered across the range of transportation planning processes and products developed by Stat...

An MILP modeling approach for shelf life integrated planning in yoghurt production

NARCIS (Netherlands)

Lütke Entrup, M.; Grunow, M.; Günther, H.O.; Seiler, T.; Beek, van P.

2005-01-01

In the production of perishable products such as dairy, meat, or bakery goods, the consideration of shelf life in production planning is of particular importance. Retail customers with relatively low inventory turns can benefit significantly from longer product shelf life as wastage and out-of-stock

Shifting Perspectives and Practices: Teacher Candidates’ Experiences of a First Nation, Métis, and Inuit Infusion in Mainstream Teacher Education

Directory of Open Access Journals (Sweden)

Melissa Marilyn Fern Blimkie

2014-10-01

Full Text Available This exploratory case study shares teacher candidates’ perspectives and experiences of the First Nation, Métis, and Inuit Infusion at ABC University’s Faculty of Education field site in XYZ, Ontario. For this initiative, Aboriginal content and pedagogies were infused throughout placements and courses of the mainstream teacher education program. Teacher candidates shared that the Infusion prepared them to teach Aboriginal content in culturally respectful and meaningful ways by providing them with a foundation to build on and helping them to develop teaching practices inclusive of diverse ways of knowing and being in the world. These findings may be useful to other educators developing and implementing their own infusion initiatives.

Practical application of game theory based production flow planning method in virtual manufacturing networks

Science.gov (United States)

Olender, M.; Krenczyk, D.

2016-08-01

Modern enterprises have to react quickly to dynamic changes in the market, due to changing customer requirements and expectations. One of the key area of production management, that must continuously evolve by searching for new methods and tools for increasing the efficiency of manufacturing systems is the area of production flow planning and control. These aspects are closely connected with the ability to implement the concept of Virtual Enterprises (VE) and Virtual Manufacturing Network (VMN) in which integrated infrastructure of flexible resources are created. In the proposed approach, the players role perform the objects associated with the objective functions, allowing to solve the multiobjective production flow planning problems based on the game theory, which is based on the theory of the strategic situation. For defined production system and production order models ways of solving the problem of production route planning in VMN on computational examples for different variants of production flow is presented. Possible decision strategy to use together with an analysis of calculation results is shown.

Knowledge co-production and boundary work to promote implementation of conservation plans.

Science.gov (United States)

Nel, Jeanne L; Roux, Dirk J; Driver, Amanda; Hill, Liesl; Maherry, Ashton C; Snaddon, Kate; Petersen, Chantel R; Smith-Adao, Lindie B; Van Deventer, Heidi; Reyers, Belinda

2016-02-01

Knowledge co-production and boundary work offer planners a new frame for critically designing a social process that fosters collaborative implementation of resulting plans. Knowledge co-production involves stakeholders from diverse knowledge systems working iteratively toward common vision and action. Boundary work is a means of creating permeable knowledge boundaries that satisfy the needs of multiple social groups while guarding the functional integrity of contributing knowledge systems. Resulting products are boundary objects of mutual interest that maintain coherence across all knowledge boundaries. We examined how knowledge co-production and boundary work can bridge the gap between planning and implementation and promote cross-sectoral cooperation. We applied these concepts to well-established stages in regional conservation planning within a national scale conservation planning project aimed at identifying areas for conserving rivers and wetlands of South Africa and developing an institutional environment for promoting their conservation. Knowledge co-production occurred iteratively over 4 years in interactive stake-holder workshops that included co-development of national freshwater conservation goals and spatial data on freshwater biodiversity and local conservation feasibility; translation of goals into quantitative inputs that were used in Marxan to select draft priority conservation areas; review of draft priority areas; and packaging of resulting map products into an atlas and implementation manual to promote application of the priority area maps in 37 different decision-making contexts. Knowledge co-production stimulated dialogue and negotiation and built capacity for multi-scale implementation beyond the project. The resulting maps and information integrated diverse knowledge types of over 450 stakeholders and represented >1000 years of collective experience. The maps provided a consistent national source of information on priority conservation areas

Visual Grouping in Accordance With Utterance Planning Facilitates Speech Production

Directory of Open Access Journals (Sweden)

Liming Zhao

2018-03-01

Full Text Available Research on language production has focused on the process of utterance planning and involved studying the synchronization between visual gaze and the production of sentences that refer to objects in the immediate visual environment. However, it remains unclear how the visual grouping of these objects might influence this process. To shed light on this issue, the present research examined the effects of the visual grouping of objects in a visual display on utterance planning in two experiments. Participants produced utterances of the form “The snail and the necklace are above/below/on the left/right side of the toothbrush” for objects containing these referents (e.g., a snail, a necklace and a toothbrush. These objects were grouped using classic Gestalt principles of color similarity (Experiment 1 and common region (Experiment 2 so that the induced perceptual grouping was congruent or incongruent with the required phrasal organization. The results showed that speech onset latencies were shorter in congruent than incongruent conditions. The findings therefore reveal that the congruency between the visual grouping of referents and the required phrasal organization can influence speech production. Such findings suggest that, when language is produced in a visual context, speakers make use of both visual and linguistic cues to plan utterances.

Visual Grouping in Accordance With Utterance Planning Facilitates Speech Production.

Science.gov (United States)

Zhao, Liming; Paterson, Kevin B; Bai, Xuejun

2018-01-01

Research on language production has focused on the process of utterance planning and involved studying the synchronization between visual gaze and the production of sentences that refer to objects in the immediate visual environment. However, it remains unclear how the visual grouping of these objects might influence this process. To shed light on this issue, the present research examined the effects of the visual grouping of objects in a visual display on utterance planning in two experiments. Participants produced utterances of the form "The snail and the necklace are above/below/on the left/right side of the toothbrush" for objects containing these referents (e.g., a snail, a necklace and a toothbrush). These objects were grouped using classic Gestalt principles of color similarity (Experiment 1) and common region (Experiment 2) so that the induced perceptual grouping was congruent or incongruent with the required phrasal organization. The results showed that speech onset latencies were shorter in congruent than incongruent conditions. The findings therefore reveal that the congruency between the visual grouping of referents and the required phrasal organization can influence speech production. Such findings suggest that, when language is produced in a visual context, speakers make use of both visual and linguistic cues to plan utterances.

An MILP approach to shelf life integrated planning and scheduling in scalded sausage production

DEFF Research Database (Denmark)

Günther, H.O.; van Beek, P.; Grunow, Martin

2006-01-01

in which shelf life aspects are integrated into operational production planning and scheduling functions. Specifically we make use of so-called Mixed Integer Linear Programming (MILP) models. Our research is based on an industrial case study of yogurt production. Relying on the principle of block planning...

Improving productivity levels: family planning services for factory workers.

Science.gov (United States)

Darmokusumo, H V

1989-10-01

In May 1984, the Minister of Manpower in Indonesia, the Chairman of the BKKBN, and representatives of the employers' and workers' organizations of Indonesia issued a joint decree pledging that they would work together to enhance the implementation of the family planning program among workers in the organized sector. 1 objective of the decree is to improve workers' productivity and the standard of living of workers and their families by implementing a family planning program. 1 baseline survey and a clinic-based survey in 5 provinces revealed that 90% of women workers are between 21-40, or are of reproductive age, and are sexually active. Only about 50% are practicing family planning; the other 50% are afraid to practice family planning due to potential side effects of various methods. This fear was most often caused by negative rumors spread by unsatisfied family planning clients. Placing materials for family planning promotion such as instructional posters and video programs advertising contraceptive services in the work setting may increase knowledge and help alleviate some of this fear. Other studies of family planning services show that employees prefer female medical doctors or midwives as service providers, employees are willing to pay for services (but can only afford a small fee), and family planning service points should be near employees' work sites.

Stochastic multi-period multi-product multi-objective Aggregate Production Planning model in multi-echelon supply chain

Directory of Open Access Journals (Sweden)

Kaveh Khalili-Damghani

2017-07-01

Full Text Available In this paper a multi-period multi-product multi-objective aggregate production planning (APP model is proposed for an uncertain multi-echelon supply chain considering financial risk, customer satisfaction, and human resource training. Three conflictive objective functions and several sets of real constraints are considered concurrently in the proposed APP model. Some parameters of the proposed model are assumed to be uncertain and handled through a two-stage stochastic programming (TSSP approach. The proposed TSSP is solved using three multi-objective solution procedures, i.e., the goal attainment technique, the modified ε-constraint method, and STEM method. The whole procedure is applied in an automotive resin and oil supply chain as a real case study wherein the efficacy and applicability of the proposed approaches are illustrated in comparison with existing experimental production planning method.

Qualification of the system for thermal coating rehabilitation in situ of oil pipeline in operation; Qualificacao de sistema de reabilitacao in situ de revestimento termico para oleodutos

Energy Technology Data Exchange (ETDEWEB)

Koebsch, Andre; Correa, Anyr Rosa; Cabral, Glaucia Brazuna; Castanheiras Junior, Wilson Gil [PETROBRAS, Rio de Janeiro, RJ (Brazil); Oliver, Joao Hipolito de Lima; Pinto, Mucio Eduardo Amarante Costa [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

2005-07-01

The transfer of some derived products of petroleum with high viscosity is accomplished with the same ones heated up. These buried pipelines are provided of Thermal Isolation System (TIS). Those TIS are composed with a polyurethane foam layer (PU) that is externally protected by polyethylene layer (PE). The acids production was generated by the deterioration of TIS. This associated with an absence of anticorrosive coating on the pipeline cause the corrosion with its thickness loss and consequently it's endangered. The rehabilitation of the existent TIS was done necessary to control this corrosive process, by reason of the Cathodic Protection System usually used in complement to the anticorrosive coating does not work on this TIS. A TIS rehabilitation process with the pipeline in operation was specified by PETROBRAS - ENGINEER and TRANSPETRO. It's qualified and was composed by two stages: Pre-qualification: tests in factory using pipes with original TIS and operating with hot water to 85 deg C. This stage was composed by the removal of original TIS, pipe surface preparation, application and tests on the anticorrosive coating, application and tests of the PU foam and application and tests of the PE casing. Qualification: stage composed by the application in field of the new TIS in a thousand meters of the pipeline OBATI-SP, operated by TRANSPETRO, and tests of the pipe assembly. This work presents the results of the Qualification for the rehabilitation of the thermal coating. It achieves the quality level demanded by PETROBRAS - Engineer and TRANSPETRO. (author)

A Fuzzy Linear Programming Approach for Aggregate Production Planning

DEFF Research Database (Denmark)

Iris, Cagatay; Cevikcan, Emre

2014-01-01

a mathematical programming framework for aggregate production planning problem under imprecise data environment. After providing background information about APP problem, together with fuzzy linear programming, the fuzzy linear programming model of APP is solved on an illustrative example for different a...

Approach for planning and operation of energy-efficient production systems; Vorgehensweise fuer Planung und Betrieb energieeffizienter Produktionssysteme

Energy Technology Data Exchange (ETDEWEB)

Weinert, Nils

2010-07-02

The integration of energy efficiency criteria into planning and operating of production systems substantially contributes to resource productivity and thus is an essential prerequisite for global sustainable development. Great potential can be identified for an early consideration of energy efficiency measures in an early planning phase. It is necessary to determine energy requirements during the planning process before the system is implemented. The objective of this thesis is the development of a planning system for the detailed prognosis of a production system's energy consumption. A concept is derived, by which a time based prediction of the amount of energy required by each machine and thus by the whole production system becomes possible. The planning system is methodologically integrated with well established approaches for manufacturing and factory planning. The methodology is based on the separation of production processes into segments, each with specific energy consumption. These segments, which are defined for equipment according to the possible operational states, are called EnergyBlocks. Each EnergyBlock describes the energy consumed and has a fixed or variable duration. A fixed duration results from operational states which last the shortest time technically possible, for example a machine start process. Variable durations represent operational states, whose length are dependant of the production task. Examples are manufacturing processes. The energy consumption of one block is mathematically described using power series. The energy consumption profile of a planned, not yet realized production process is modeled by arranging the EnergyBlocks to sequences. Depending on when the developed planning system is applied in the process of manufacturing and factory planning, energy consumption prognosis can be calculated as a power profile or as total consumption values, using the same model for both cases. Thus, the information density can be chosen

Computer Aided Process Planning for Non-Axisymmetric Deep Drawing Products

Science.gov (United States)

Park, Dong Hwan; Yarlagadda, Prasad K. D. V.

2004-06-01

In general, deep drawing products have various cross-section shapes such as cylindrical, rectangular and non-axisymmetric shapes. The application of the surface area calculation to non-axisymmetric deep drawing process has not been published yet. In this research, a surface area calculation for non-axisymmetric deep drawing products with elliptical shape was constructed for a design of blank shape of deep drawing products by using an AutoLISP function of AutoCAD software. A computer-aided process planning (CAPP) system for rotationally symmetric deep drawing products has been developed. However, the application of the system to non-axisymmetric components has not been reported yet. Thus, the CAPP system for non-axisymmetric deep drawing products with elliptical shape was constructed by using process sequence design. The system developed in this work consists of four modules. The first is recognition of shape module to recognize non-axisymmetric products. The second is a three-dimensional (3-D) modeling module to calculate the surface area for non-axisymmetric products. The third is a blank design module to create an oval-shaped blank with the identical surface area. The forth is a process planning module based on the production rules that play the best important role in an expert system for manufacturing. The production rules are generated and upgraded by interviewing field engineers. Especially, the drawing coefficient, the punch and die radii for elliptical shape products are considered as main design parameters. The suitability of this system was verified by applying to a real deep drawing product. This CAPP system constructed would be very useful to reduce lead-time for manufacturing and improve an accuracy of products.

The key to successful management of STS operations: An integrated production planning system

Science.gov (United States)

Johnson, W. A.; Thomasen, C. T.

1985-01-01

Space Transportation System operations managers are being confronted with a unique set of challenges as a result of increasing flight rates, the demand for flight manifest/production schedule flexibility and an emphasis on continued cost reduction. These challenges have created the need for an integrated production planning system that provides managers with the capability to plan, schedule, status and account for an orderly flow of products and services across a large, multi-discipline organization. With increased visibility into the end-to-end production flow for individual and parallel missions in process, managers can assess the integrated impact of changes, identify and measure the interrelationships of resource, schedule, and technical performance requirements and prioritize productivity enhancements.

Engineering Environment for Production System Planning in Small and Medium Enterprises

OpenAIRE

Goerzig, David; Lucke, Dominik; Lenz, Juergen; Denner, Timo; Lickefett, Michael; Bauernhansl, Thomas

2015-01-01

Today, factories have to be adapted permanently in order to follow the developments towards fast changing customer demands and faster life cycles of products. Key aspects to cope with these developments are the reduction of the unit costs and the planning duration as well as the improvement of the planning quality. In order to overcome these challenges, digital tools can support all phases of factory and process planning. Most of them provide a wide range of functionalities, which require a l...

Can Differentiated Production Planning and Control enable both Responsiveness and Efficiency in Food Production?

Directory of Open Access Journals (Sweden)

Anita Romsdal

2014-07-01

Full Text Available This paper addresses the complex production planning and control (PPC challenges in food supply chains. The study illustrates how food producers' traditional make‐to‐stock (MTS approach is not well suited to meet the trends of increasing product variety, higher demand uncertainty, increasing sales of fresh food products and more demanding customers. The paper proposes a framework for differentiated PPC that combines MTS with make‐to‐order (MTO.The framework matches products with the most appropriate PPC approaches and buffering techniques depending on market and product characteristics. The core idea is to achieve more volume flexibility in the production system by exploiting favourable product and market characteristics (high demand predictability, long customer order leadtime allowances and low product perishability. A case study is used to demonstrate how the framework can enable food producers to achieve efficiency in production, inventory and PPC processes – and simultaneously be responsive to market requirements.

Improving food safety in the supply chain: Integrating traceability in production and distribution planning

DEFF Research Database (Denmark)

Grunow, Martin; Rong, Aiying; Akkerman, Renzo

2008-01-01

on production and distribution planning. Here, we develop a methodology for production and distribution planning in food supply chains which minimizes production and logistics costs and at the same time reduces food safety concerns, limits the size of potential recalls, and satisfies product quality...... with traceability from the viewpoint of information system development and technology development such as radio frequency identification (RFID) and DNA-based techniques. However, traceability and its implications for food safety are thus far not incorporated in the standard operations management literature...

Summary of strategies for planning Productivity Improvement and Quality Enhancement (PIQE)

Science.gov (United States)

1986-01-01

The Summary of NASA Strategies for Productivity Improvement and Quality Enhancement respond to NASA's eighth top goal: Establish NASA as a leader in the development and application of advanced technology and management practices which contribute to significant increases in both Agency and national productivity. The Strategies provide the framework for development of the agency-wide Productivity Improvement and Quality Enhancement (PIQE) Plans.

The importance of work or productive activity in life care planning and case management.

Science.gov (United States)

Reid, Christine; Riddick-Grisham, Susan

2015-01-01

The importance of work or productive activity for the well-being, community integration, and quality of life of people living with disabilities is addressed, with implications for life care planning and case management. The role of work or productive activity in our society, and consequences of deprivation if rehabilitation services do not address vocational effects of disabilities, is explored. A continuum of productivity options is introduced; types of vocational rehabilitation assessment processes and interventions are described. The role of vocational rehabilitation services in life care planning and case management is discussed, focusing on quality of life for people living with disabilities. Rehabilitation and health care professionals should understand the importance of work or other productive activity, and support the development of appropriate plans to address those needs among people who have disabilities.

The Effects of Pre-Task Planning and On-line Planning on Fluency, Complexity, and Accuracy in L2 Monologic Oral Production.

Science.gov (United States)

Yuan, Fangyuan; Ellis, Rod

2003-01-01

Investigated the effects of both pre-task and on-line planning on second language (L2) oral production. Results show that pre-task planning enhances grammatical complexity while on-line planning positively influences accuracy and grammatical complexity. Pre-task planners also produced more fluent and lexically varied language than the on-line…

Hybrid production planning system in make-to-order company - case study

Directory of Open Access Journals (Sweden)

2010-12-01

Full Text Available This paper presents hybrid production planning and shop floor control system in make-to-order manufacturing of complex products. It presents the general idea of multi-hybrid system and selected practical aspects of its creation and its implementation. The construction of this system is based on the planning and executive levels and main aspects of its integration and its support tools. The research was carried out in HCP S.A. Poznan (Diesel Engines and Generating Sets Factory. HCP S.A. Poznan is the producer of high-power marine engines. The lead-time of the final product manufacturing is between 9 months and 1 year, and takes about 40.000 hours per one engine. The main problems of this production system are high share of the work in progress and long lead-time, which, as a result, causes many expenses. The flow of material streams is extremely complex and represents "A-plant" class, according to V-A-T classification, including significant internal constraints ("bottlenecks".

MULTI-CRITERIA PROGRAMMING METHODS AND PRODUCTION PLAN OPTIMIZATION PROBLEM SOLVING IN METAL INDUSTRY

OpenAIRE

Tunjo Perić; Željko Mandić

2017-01-01

This paper presents the production plan optimization in the metal industry considered as a multi-criteria programming problem. We first provided the definition of the multi-criteria programming problem and classification of the multicriteria programming methods. Then we applied two multi-criteria programming methods (the STEM method and the PROMETHEE method) in solving a problem of multi-criteria optimization production plan in a company from the metal industry. The obtained resul...

Status, plans, and capabilities of the Nuclear Criticality Information System

International Nuclear Information System (INIS)

Koponen, B.L.

1984-01-01

The Nuclear Criticality Information System (NCIS), in preparation since 1981, has substantially evolved and now contains a growing number of resources pertinent to nuclear criticality safety. These resources include bibliographic compilations, experimental data, communications media, and the International Directory of Nuclear Criticality Safety Personnel. These resources are part of the LLNL Technology Information System (TIS) which provides the host computer for NCIS. The TIS provides nationwide access to authorized members of the nuclear criticality community via interactive dial-up from computer terminals that utilize communication facilities such as commercial and federal telephone networks, toll-free WATS lines, TYMNET, and the ARPANET/MILNET computer network

Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single Cells.

Science.gov (United States)

Lee, Jinwoo; Tong, Tiegang; Duan, Haichuan; Foong, Yee Hoon; Musaitif, Ibrahim; Yamazaki, Takeshi; Jefcoate, Colin

2016-01-01

The cholesterol transfer function of steroidogenic acute regulatory protein (StAR) is uniquely integrated into adrenal cells, with mRNA translation and protein kinase A (PKA) phosphorylation occurring at the mitochondrial outer membrane (OMM). The StAR C-terminal cholesterol-binding domain (CBD) initiates mitochondrial intermembrane contacts to rapidly direct cholesterol to Cyp11a1 in the inner membrane (IMM). The conserved StAR N-terminal regulatory domain (NTD) includes a leader sequence targeting the CBD to OMM complexes that initiate cholesterol transfer. Here, we show how the NTD functions to enhance CBD activity delivers more efficiently from StAR mRNA in adrenal cells, and then how two factors hormonally restrain this process. NTD processing at two conserved sequence sites is selectively affected by StAR PKA phosphorylation. The CBD functions as a receptor to stimulate the OMM/IMM contacts that mediate transfer. The NTD controls the transit time that integrates extramitochondrial StAR effects on cholesterol homeostasis with other mitochondrial functions, including ATP generation, inter-organelle fusion, and the major permeability transition pore in partnership with other OMM proteins. PKA also rapidly induces two additional StAR modulators: salt-inducible kinase 1 (SIK1) and Znf36l1/Tis11b. Induced SIK1 attenuates the activity of CRTC2, a key mediator of StAR transcription and splicing, but only as cAMP levels decline. TIS11b inhibits translation and directs the endonuclease-mediated removal of the 3.5-kb StAR mRNA. Removal of either of these functions individually enhances cAMP-mediated induction of StAR. High-resolution fluorescence in situ hybridization (HR-FISH) of StAR RNA reveals asymmetric transcription at the gene locus and slow RNA splicing that delays mRNA formation, potentially to synchronize with cholesterol import. Adrenal cells may retain slow transcription to integrate with intermembrane NTD activation. HR-FISH resolves individual 3.5-kb St

Optimization of production planning in Czech agricultural co-operative via linear programming

Directory of Open Access Journals (Sweden)

Jitka Janová

2009-01-01

Full Text Available The production planning is one of the key managerial decisions in agricultural business, which must be done periodically every year. Correct decision must cover the agriculture demands of planting the crops such as crop rotation restrictions or water resource scarcity, while the decision maker aims to plan the crop design in most profitable way in sense of maximizing the total profit from the crop yield. This decision problem represents the optimization of crop design and can be treated by the me­thods of linear programming which begun to be extensively used in agriculture production planning in USA during 50’s. There is ongoing research of mathematical programming applications in agriculture worldwide, but the results are not easily transferable to other localities due to the specific local restrictions in each country. In Czech Republic the farmers use for production planning mainly their expert knowledge and past experience. However, the mathematical programming approach enables find the true optimal solution of the problem, which especially in the problems with a great number of constraints is not easy to find intuitively. One of the possible barriers for using the general decision support systems (which are based on mathematical programming methods for agriculture production planning in Czech Republic is its expensiveness. The small farmer can not afford to buy the expensive software or to employ a mathematical programming specialist. The aim of this paper is to present a user friendly linear programming model of the typical agricultural production planning problem in Czech Republic which can be solved via software tools commonly available in any farm (e.g. EXCEL. The linear programming model covering the restrictions on total costs, crop rotation, thresholds for the total area sowed by particular crops, total amount of manure and the need of feed crops is developed. The model is applied in real-world problem of Czech agriculture

A New Extended MILP MRP Approach to Production Planning and Its Application in the Jewelry Industry

Directory of Open Access Journals (Sweden)

Erhan Yazıcı

2016-01-01

Full Text Available It is important to manage reverse material flows such as recycling, reusing, and remanufacturing in a production environment. This paper addresses a production planning problem which involves reusing of scrap and recycling of waste that occur in the various stages of the production process and remanufacturing/recycling of returns in a closed-loop supply chain environment. An extended material requirement planning (MRP is proposed as a mixed integer linear programming (MILP model which includes—beside forward—these reverse material flows. The proposed model is developed for the jewelry industry in Turkey, which uses gold as the primary resource of production. The aim is to manage these reverse material flows as a part of production planning to utilize resources. Considering the mostly unpredictable nature of reverse material flows, the proposed model is likewise transformed into a fuzzy model to provide a better review of production plan for the decision maker. The suggested model is examined through a case study to test the applicability and efficiency.

A model for marketing planning of new products

DEFF Research Database (Denmark)

Martensen, Anne

1994-01-01

Executive Summary: 1. A model for forecasting the sales of a new product is presented. This model allows to predict the sales development of a new product before it is actually launched on the market. 2. The model makes separate forecasts for the volume of trial and repeat purchases. It also...... incorporates a special model to explain consumer awareness of the new product. 3. Consumer awareness is explained by distribution (shelf facings and in-store promotion), advertising and giving away free samples. 4. The trial model incorporates the total market potential, the probability of being in a buying...... the product after some time. 6. The model requires three types of data input: market data, market research data, and marketing plan data. Using these data, prediction can be made by a user-friendly PC programme. 7. An example is shown demonstrating that the predictions made by the model were in good...

Case study of information product for strategy research, planning research, and policy research

International Nuclear Information System (INIS)

Yuan Yujun; Zou Lin; Liu Qun; Wang Yongping

2010-01-01

Soft science research is significant and can directly support the decision-making and development. The strategy research, planning research, and policy research each play an important role in soft science research. As the National Strategy of Informatization being implemented and advanced, some progress are made and some special information tools are produced in the process of strengthening the development research with information technologies. At first, the article introduced some cases of information products application, such as the domestic and overseas information products for energy strategy research and planning research and policy research, the governmental management information system for planning and investment, examination and approval and permission system for the planning of the land for construction, China agriculture decision support system and so on, and also gave a brief analysis on the theories and methods, main functions and application status. And then, with a analysis on the features of the works of development planning of China National Nuclear Corporation (CNNC) development, this article gave some suggestions on how to strengthen the development of information system for the development planning of the CNNC. (authors)

The importance of work or productive activity in life care planning and case management

Science.gov (United States)

Reid, Christine; Riddick-Grisham, Susan

2015-01-01

Abstract INTRODUCTION: The importance of work or productive activity for the well-being, community integration, and quality of life of people living with disabilities is addressed, with implications for life care planning and case management. BACKGROUND: The role of work or productive activity in our society, and consequences of deprivation if rehabilitation services do not address vocational effects of disabilities, is explored. A continuum of productivity options is introduced; types of vocational rehabilitation assessment processes and interventions are described. PURPOSE: The role of vocational rehabilitation services in life care planning and case management is discussed, focusing on quality of life for people living with disabilities. CONCLUSION: Rehabilitation and health care professionals should understand the importance of work or other productive activity, and support the development of appropriate plans to address those needs among people who have disabilities. PMID:26409330

Tank 241-AZ-102 Privatization Push Mode Core Sampling and Analysis Plan

International Nuclear Information System (INIS)

RASMUSSEN, J.H.

1999-01-01

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AZ-102. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AZ-102 required to satisfy the Data Quality Objectives For TWRS Privatization Phase I : Confirm Tank TIS An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO) (Nguyen 1999a), Data Quality Objectives For TWRS Privatization Phase 1: Confirm Tank TIS An Appropriate Feed Source For Low-Activity Waste Feed Batch X (LAW DQO) (Nguyen 1999b), Low Activity Waste and High Level Waste Feed Data Quality Objectives (L and H DQO) (Patello et al. 1999) and Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO) (Bloom 1996). The Tank Characterization Technical Sampling Basis document (Brown et al. 1998) indicates that these issues, except the Equipment DQO apply to tank 241-AZ-102 for this sampling event. The Equipment DQO is applied for shear strength measurements of the solids segments only. Poppiti (1999) requires additional americium-241 analyses of the sludge segments. Brown et al. (1998) also identify safety screening, regulatory issues and provision of samples to the Privatization Contractor(s) as applicable issues for this tank. However, these issues will not be addressed via this sampling event. Reynolds et al. (1999) concluded that information from previous sampling events was sufficient to satisfy the safety screening requirements for tank 241-AZ-102. Push mode core samples will be obtained from risers 15C and 24A to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples, composite the liquids and solids, perform chemical analyses

Fuzzy production planning models for an unreliable production system with fuzzy production rate and stochastic/fuzzy demand rate

Directory of Open Access Journals (Sweden)

K. A. Halim

2011-01-01

Full Text Available In this article, we consider a single-unit unreliable production system which produces a single item. During a production run, the production process may shift from the in-control state to the out-of-control state at any random time when it produces some defective items. The defective item production rate is assumed to be imprecise and is characterized by a trapezoidal fuzzy number. The production rate is proportional to the demand rate where the proportionality constant is taken to be a fuzzy number. Two production planning models are developed on the basis of fuzzy and stochastic demand patterns. The expected cost per unit time in the fuzzy sense is derived in each model and defuzzified by using the graded mean integration representation method. Numerical examples are provided to illustrate the optimal results of the proposed fuzzy models.

Preliminar plan of a machine for the synchrotron radiation production

International Nuclear Information System (INIS)

Moscati, G.; Takahashi, J.; Miyao, Y.

1985-01-01

A preliminar plan, with all the technical specifications, for the construction of a machine for the synchrotron radiation production to be done by the National Synchrotron Radiation Laboratory in Brazil is presented. (L.C.) [pt

Production, staff, working time and financial planning

Directory of Open Access Journals (Sweden)

Orlando Boiteux

2009-07-01

Full Text Available Aggregate planning can be a tool for coordinating the tactical decisions belonging to some functional areas of a company. This potential has been limited due to methodological and technical reasons, but nowadays it is possible to solve very sophisticated models integrating, with a high level of detail, a great number of decisions of several functional areas and that permit to include new management schemes. In this paper, a production, staff, working time and cash management model is introduced.

Interfaz entre el plan de producción y el programa de producción en ambientes de ensamble Interface between the production plan and the master production schedule in assembly environments

Directory of Open Access Journals (Sweden)

Marcos Moya Navarro

2012-11-01

Full Text Available En un entorno de producción existe una relación directa entre el mercado y los procesos de manufactura de los bienes. Sin embargo, cuando la producción está inmersa en un ambiente de ensamble, el procedimiento de la planificación y la programación se vuelve complejo, con el riesgo de que la empresa pierda ventaja competitiva en términos de incumplimiento de las fechas de entrega y elevados costos de planificación y control. La programación lineal constituye una herramienta apropiada para construir modelos de programación y control de la producción en entornos de manufactura complejos. El objetivo de este trabajo es mostrar la interfaz entre el plan de producción y el programa de producción en ambientes de ensamble mediante el modelado por programación lineal. Para ello, se seleccionó un entorno que produce tres productos finales cuya estructura de producto está dispuesta en tres niveles con un máximo de ocho componentes. Los datos proporcionados por el plan de producción se desglosaron en diez órdenes, cada una indicando el tipo de producto, la cantidad por producir y su respectiva fecha de entrega. Los resultados obtenidos en el programa de producción establecieron la recepción de pedidos planificados y el programa de componentes totales requeridos en cada periodo de producción, para minimizar los costos totales de emisión de órdenes de producción e inventario.In a production environment there is a direct relationship between the market and the manufacturing process of goods.When production is immersed in an assembly environment, the process of production planning and scheduling becomes complex, and the enterprises have the risk of losing competitive advantages in terms of not meeting delivery dates and production high costs. Linear programming has become an appropriate tool for production planning and scheduling in complex manufacturing environments. The aim of this paper is to show the interface between both the

Products for geoinformation support for spatial planning and management within the framework of the project ONIX

Directory of Open Access Journals (Sweden)

Franc J. Zakrajšek

2000-01-01

Full Text Available The article gives a brief description of four products in the subproject Geoinformation support for physical planning and spatial management on the local level in the framework of the Onix project. The products are a result of a comprehensive approach to the development of information support, whose main features are unified dealing with planning acts, from the statutory plan and development plans to permitting procedures, multi-disciplinary approach and object oriented information approach.

Multi-assortment rhythmic production planning and control

Science.gov (United States)

Skolud, B.; Krenczyk, D.; Zemczak, M.

2015-11-01

A method for production planning in a repetitive manufacturing system which allows for estimating the possibility of processing work orders in due time is presented. The difference between two approaches are presented; the first one one-piece flow elaborated in Toyota and the second one elaborated by authors that consists in defining sufficient conditions to filter all solutions and providing a set of admissible solutions for both the client and the producer. In the paper attention is focused on the buffer allocation. Illustrative examples are presented.

Product Plan of New Generation System Camera "OLYMPUS PEN E-P1"

Science.gov (United States)

Ogawa, Haruo

"OLYMPUS PEN E-P1", which is new generation system camera, is the first product of Olympus which is new standard "Micro Four-thirds System" for high-resolution mirror-less cameras. It continues good sales by the concept of "small and stylish design, easy operation and SLR image quality" since release on July 3, 2009. On the other hand, the half-size film camera "OLYMPUS PEN" was popular by the concept "small and stylish design and original mechanism" since the first product in 1959 and recorded sale number more than 17 million with 17 models. By the 50th anniversary topic and emotional value of the Olympus pen, Olympus pen E-P1 became big sales. I would like to explain the way of thinking of the product plan that included not only the simple functional value but also emotional value on planning the first product of "Micro Four-thirds System".

Productive and Economic Performance of Broiler Chickens Subjected to Different Nutritional Plans

Directory of Open Access Journals (Sweden)

JMS Martins

Full Text Available ABSTRACT The objective of the study was to evaluate the effect of nutritional plans on the productive and economic performance of Hubbard Flex broiler chickens. A completely randomized experimental design was applied, consisting of five treatments. Treatments consisted of five different nutritional plans: a basal diet containing the nutrient and energy levels recommended by literature and designated reference diet; two diets containing 1.5% and 3% lower levels than the reference diet; and two diets containing 1.5% and 3% higher levels than the reference diet (-3%, -1.5%, reference plan, +1.5% and +3%. Feed intake (FI, body weight (BW, feed conversion rate (FCR, livability (L and productive efficient index (PEI were determined when broilers were 42 days old. Broilers were processed, and carcass and parts (breast fillet, leg, and wings yields were determined. The economic viablility of the nutitional plans was evaluated as a function of feed cost/kg live and carcass weights, economic efficiency index (EEI, and cost index (CI. Feed intake and the feed conversion rate decreased as dietary nutrient and energy levels increased. Feed cost/kg live weight, economic efficiency index, and cost index cost increased as dietary nutrient and energy levels increased. Feed intake, feed conversion ratio, production efficiency index, and breast yield improved with increasing nutritional and energy levels. However, worse economic results were obtained with higher nutritional and energy levels.

AN APPROACH TO FINANCIAL RISK IN A PORTFOLIO FOR PLANNING THE INDUSTRIAL PRODUCTION OF PRODUCTS DERIVED FROM SUGARCANE

Directory of Open Access Journals (Sweden)

Thárcylla R.N. Clemente

2015-12-01

Full Text Available ABSTRACT Brazil's location and tropical weather conditions are favourable cultivating sugarcane, which has led to Brazil being one of the world's largest producers of sugarcane. The influence of the sugarcane industry on its economy stands out among the indicators of Brazilian economic growth and because the diversified investment when planning the production of products derived from this sector is encouraged. The decision on which derivative (for example, crystal sugar, anhydrous ethanol, or hydrous ethanol to produce from raw sugarcane can be modelled as an investment decision in a portfolio decision problem whenever a combination of these products is considered. As to the future price of these commodities, raw sugarcane is considered to be capital that should be invested. Thus, this paper puts forward a decision model which uses concepts from Decision Analysis and Bayesian Risk Analysis that may well assist the process of managing assets in the Brazilian sugarcane industry by considering the financial aspect when compiling a portfolio for planning production.

Radioisotope Production Plan and Strategy of Kijang Research Reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Kye Hong; Lee, Jun Sig [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-05-15

This reactor will be located at Kijang, Busan, Korea and be dedicated to produce mainly medical radioisotopes. Tc-99m is very important isotope for diagnosis and more than 80% of radiation diagnostic procedures in nuclear medicine depend on this isotope. There were, however, several times of insecure production of Mo-99 due to the shutdown of major production reactors worldwide. OECD/NEA is leading member countries to resolve the shortage of this isotope and trying to secure the international market of Mo-99. The radioisotope plan and strategy of Kijang Research Reactor (KJRR) should be carefully established to fit not only the domestic but also international demand on Mo-99. The implementation strategy of 6 principles of HLG-MR should be established that is appropriate to national environments. Ministry of Science, ICT and Future Planning and Ministry of Health and welfare should cooperate well to organize the national radioisotope supply structure, to set up the reasonable and competitive pricing of radioisotopes, and to cope with the international supply strategy.

Optimizing Maintenance Planning in the Production Industry Using the Markovian Approach

Directory of Open Access Journals (Sweden)

B Kareem

2012-12-01

Full Text Available Maintenance is an essential activity in every manufacturing establishment, as manufacturing effectiveness counts on the functionality of production equipment and machinery in terms of their productivity and operational life. Maintenance cost minimization can be achieved by adopting an appropriate maintenance planning policy. This paper applies the Markovian approach to maintenance planning decision, thereby generating optimal maintenance policy from the identified alternatives over a specified period of time. Markov chains, transition matrices, decision processes, and dynamic programming models were formulated for the decision problem related to maintenance operations of a cable production company. Preventive and corrective maintenance data based on workloads and costs, were collected from the company and utilized in this study. The result showed variability in the choice of optimal maintenance policy that was adopted in the case study. Post optimality analysis of the process buttressed the claim. The proposed approach is promising for solving the maintenance scheduling decision problems of the company.

Two efficient heuristics to solve the integrated load distribution and production planning problem

International Nuclear Information System (INIS)

Gajpal, Yuvraj; Nourelfath, Mustapha

2015-01-01

This paper considers a multi-period production system where a set of machines are arranged in parallel. The machines are unreliable and the failure rate of machine depends on the load assigned to the machine. The expected production rate of the system is considered to be a non-monotonic function of its load. Because of the machine failure rate, the total production output depends on the combination of loads assigned to different machines. We consider the integration of load distribution decisions with production planning decision. The product demands are considered to be known in advance. The objective is to minimize the sum of holding costs, backorder costs, production costs, setup costs, capacity change costs and unused capacity costs while satisfying the demand over specified time horizon. The constraint is not to exceed available repair resources required to repair the machine breakdown. The paper develops two heuristics to solve the integrated load distribution and production planning problem. The first heuristic consists of a three-phase approach, while the second one is based on tabu search metaheuristic. The efficiency of the proposed heuristics is tested through the randomly generated problem instances. - Highlights: • The expected performance of the system is a non-monotonic function of its load. • We consider the integration of load distribution and production planning decisions. • The paper proposes three phase and tabu search based heuristics to solve the problem. • Lower bound has been developed for checking the effectiveness of the heuristics. • The efficiency of the heuristic is tested through randomly generated instances.

MULTI-CRITERIA PROGRAMMING METHODS AND PRODUCTION PLAN OPTIMIZATION PROBLEM SOLVING IN METAL INDUSTRY

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Tunjo Perić

2017-09-01

Full Text Available This paper presents the production plan optimization in the metal industry considered as a multi-criteria programming problem. We first provided the definition of the multi-criteria programming problem and classification of the multicriteria programming methods. Then we applied two multi-criteria programming methods (the STEM method and the PROMETHEE method in solving a problem of multi-criteria optimization production plan in a company from the metal industry. The obtained results indicate a high efficiency of the applied methods in solving the problem.

A decision support system for planning biomass-based energy production

Energy Technology Data Exchange (ETDEWEB)

Frombo, Francesco; Robba, Michela [DIST, Department of Communication, Computer and System Sciences, University of Genoa, Via Opera Pia 13, 16145 Genova (Italy); Renewable Energy Laboratory, Modelling and Optimization, Via A. Magliotto 2, 17100 Savona (Italy); Minciardi, Riccardo; Sacile, Roberto [DIST, Department of Communication, Computer and System Sciences, University of Genoa, Via Opera Pia 13, 16145 Genova (Italy)

2009-03-15

Environmental decision support systems (EDSS) are recognized as valuable tools for environmental planning and management. In this paper, a geographic information system (GIS)-based EDSS for the optimal planning of forest biomass use for energy production is presented. A user-friendly interface allows the creation of Scenarios and the running of the developed decision and environmental models. In particular, the optimization model regards decisions over a long-term period (e.g. years) and includes decision variables related to plant locations, conversion processes (pyrolisis, gasification, combustion), harvested biomass. Moreover, different energy products and different definitions of the harvesting and pre-treatment operations are taken into account. The correct management of the forest is considered through specific constraints, security factors, and procedures for parcel selection. The EDSS features and capabilities are described in detail, with specific reference to a case study. Discussion and further research are reported. (author)

Integration of landslide susceptibility products in the environmental plans

Science.gov (United States)

Fiorucci, Federica; Reichenbach, Paola; Rossi, Mauro; Cardinali, Mauro; Guzzetti, Fausto

2015-04-01

Landslides are one of the most destructive natural hazard that causes damages to urban area worldwide. The knowledge of where a landslide could occur is essential for the strategic management of the territory and for a good urban planning . In this contest landslide susceptibility zoning (LSZ) is crucial to provide information on the degree to which an area can be affected by future slope movements. Despite landslide susceptibility maps have been prepared extensively during the last decades, there are few examples of application is in the environmental plans (EP). In this work we present a proposal for the integration of the landslide inventory map with the following landslide susceptibility products: (i) landslide susceptibility zonation , (ii) the associated error map and (iii) the susceptibility uncertainty map. Moreover we proposed to incorporate detailed morphological studies for the evaluation of landslide risk associated to local parceling plan. The integration of all this information is crucial for the management of landslide risk in urban expansions forecasts. Municipality, province and regional administration are often not able to support the costs of landslide risk evaluation for extensive areas but should concentrate their financial resources to specific hazardous and unsafe situations defined by the result of the integration of landslide susceptibility products. Zonation and detail morphological analysis should be performed taking into account the existing laws and regulations, and could become a starting point to discuss new regulations for the landslide risk management.

A roadmap for cost-of-goods planning to guide economic production of cell therapy products.

Science.gov (United States)

Lipsitz, Yonatan Y; Milligan, William D; Fitzpatrick, Ian; Stalmeijer, Evelien; Farid, Suzanne S; Tan, Kah Yong; Smith, David; Perry, Robert; Carmen, Jessica; Chen, Allen; Mooney, Charles; Fink, John

2017-12-01

Cell therapy products are frequently developed and produced without incorporating cost considerations into process development, contributing to prohibitively costly products. Herein we contextualize individual process development decisions within a broad framework for cost-efficient therapeutic manufacturing. This roadmap guides the analysis of cost of goods (COG) arising from tissue procurement, material acquisition, facility operation, production, and storage. We present the specific COG considerations related to each of these elements as identified through a 2013 International Society for Cellular Therapy COG survey, highlighting the differences between autologous and allogeneic products. Planning and accounting for COG at each step in the production process could reduce costs, allowing for more affordable market pricing to improve the long-term viability of the cell therapy product and facilitate broader patient access to novel and transformative cell therapies. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

A Production Planning Model for Make-to-Order Foundry Flow Shop with Capacity Constraint

Directory of Open Access Journals (Sweden)

Xixing Li

2017-01-01

Full Text Available The mode of production in the modern manufacturing enterprise mainly prefers to MTO (Make-to-Order; how to reasonably arrange the production plan has become a very common and urgent problem for enterprises’ managers to improve inner production reformation in the competitive market environment. In this paper, a mathematical model of production planning is proposed to maximize the profit with capacity constraint. Four kinds of cost factors (material cost, process cost, delay cost, and facility occupy cost are considered in the proposed model. Different factors not only result in different profit but also result in different satisfaction degrees of customers. Particularly, the delay cost and facility occupy cost cannot reach the minimum at the same time; the two objectives are interactional. This paper presents a mathematical model based on the actual production process of a foundry flow shop. An improved genetic algorithm (IGA is proposed to solve the biobjective problem of the model. Also, the gene encoding and decoding, the definition of fitness function, and genetic operators have been illustrated. In addition, the proposed algorithm is used to solve the production planning problem of a foundry flow shop in a casting enterprise. And comparisons with other recently published algorithms show the efficiency and effectiveness of the proposed algorithm.

Product-market differentiation: a strategic planning model for community hospitals.

Science.gov (United States)

Milch, R A

1980-01-01

Community hospitals would seem to have every reason to identify and capitalize on their product-market strengths. The strategic marketing/planning model provides a framework for rational analysis of the community hospital dilemma and for developing sensible solutions to the complex problems of accelerating hospital price-inflation.

Study on environmental impact assessment index system of uranium production base construction plan

International Nuclear Information System (INIS)

Liu Xiaochao; Song Liquan

2008-01-01

The index system on planning environmental impact assessment of uranium mining base construction is discussed by using the hiberarchy method according to characteristics of uranium production and environmental protection object of planning assessment. The suggested index system is in favor of persistent exploitation of uranium resource and environmental protection in the uranium mining area, and can provide a reference for planning environmental impact assessment of uranium mining base construction in China. (authors)

A Two Stage Solution Procedure for Production Planning System with Advance Demand Information

Science.gov (United States)

Ueno, Nobuyuki; Kadomoto, Kiyotaka; Hasuike, Takashi; Okuhara, Koji

We model for ‘Naiji System’ which is a unique corporation technique between a manufacturer and suppliers in Japan. We propose a two stage solution procedure for a production planning problem with advance demand information, which is called ‘Naiji’. Under demand uncertainty, this model is formulated as a nonlinear stochastic programming problem which minimizes the sum of production cost and inventory holding cost subject to a probabilistic constraint and some linear production constraints. By the convexity and the special structure of correlation matrix in the problem where inventory for different periods is not independent, we propose a solution procedure with two stages which are named Mass Customization Production Planning & Management System (MCPS) and Variable Mesh Neighborhood Search (VMNS) based on meta-heuristics. It is shown that the proposed solution procedure is available to get a near optimal solution efficiently and practical for making a good master production schedule in the suppliers.

Stability measures for rolling schedules with applications to capacity expansion planning, master production scheduling, and lot sizing

OpenAIRE

Kimms, Alf

1996-01-01

This contribution discusses the measurement of (in-)stability of finite horizon production planning when done on a rolling horizon basis. As examples we review strategic capacity expansion planning, tactical master production schedulng, and operational capacitated lot sizing.

Practice of building production planning system of company with a wide range of products - case study

Directory of Open Access Journals (Sweden)

Łukasz Hadaś

2012-09-01

Full Text Available Background: The complexity of the manufacturing environments of today's mechanical engineering companies and the number of both internal and external restrictions affecting to need of building tailored production planning and control systems. This statement is particularly important in conditions of companies with a wide range of products and different customer service strategies (different locations of the logistics decoupling point otherwise called "order penetration point". Streams of materials in these conditions require different management what is the main reason for carrying out research in business conditions by the authors. Material and methods: The research was carried out in industrial engineering in complex environmental conditions of production. This was a specializing in technology, multi-departments environment, with multiple streams of values and a wide range of products (about 500 items. The work was carried out under the transformation of the production system from the "push" logic of flow to "pull" logic of flow and building a dedicated system based on the best practice approach. Results: The paper describes the process of building tailored hybrid systems in the area of planning and shop flow control of production. The authors present the theoretical considerations on the issue and practical experiences. The authors present factors of selection of the transformation path and its road map. The article describes the part of the authors' own experience in the work on the methodology of transformation of Polish companies in the running business condition. Conclusions: Establishing the methodology of transformation of the production system is not a simple task. This paper presents only selected aspects of complex decision-making process. However, the authors presented work shows the important aspect of the transformation of production systems for these organizational conditions.

Automating the production planning of a 3D printing factory

NARCIS (Netherlands)

Adan, I.J.B.F.; Pogromskiy, A.Y.; Freens, J.P.N.; Ploegmakers, H.; Yilmaz, L.; Chan, W.K.V.; Moon, I.; Roeder, T.M.K.; Macal, C.; Rossetti, M.D.

2015-01-01

To increase a 3D printer's throughput and decrease the print objects' lead times, composing good batches for 3D printers in high-volume 3D printing environments is of great importance. Since manual planners cannot oversee the whole production planning, they tend to make sub-optimal decisions. This

A Science Products Inventory for Citizen-Science Planning and Evaluation.

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K; Weltzin, Jake F

2018-06-01

Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science.

A science products inventory for citizen-science planning and evaluation

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K.; Weltzin, Jake F.

2018-01-01

Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science.

A Science Products Inventory for Citizen-Science Planning and Evaluation

Science.gov (United States)

Wiggins, Andrea; Bonney, Rick; LeBuhn, Gretchen; Parrish, Julia K; Weltzin, Jake F

2018-01-01

Abstract Citizen science involves a range of practices involving public participation in scientific knowledge production, but outcomes evaluation is complicated by the diversity of the goals and forms of citizen science. Publications and citations are not adequate metrics to describe citizen-science productivity. We address this gap by contributing a science products inventory (SPI) tool, iteratively developed through an expert panel and case studies, intended to support general-purpose planning and evaluation of citizen-science projects with respect to science productivity. The SPI includes a collection of items for tracking the production of science outputs and data practices, which are described and illustrated with examples. Several opportunities for further development of the initial inventory are highlighted, as well as potential for using the inventory as a tool to guide project management, funding, and research on citizen science. PMID:29867254

Robust Production Planning in Fashion Apparel Industry under Demand Uncertainty via Conditional Value at Risk

Directory of Open Access Journals (Sweden)

Abderrahim Ait-Alla

2014-01-01

Full Text Available This paper presents a mathematical model for robust production planning. The model helps fashion apparel suppliers in making decisions concerning allocation of production orders to different production plants characterized by different lead times and production costs, and in proper time scheduling and sequencing of these production orders. The model aims at optimizing these decisions concerning objectives of minimal production costs and minimal tardiness. It considers several factors such as the stochastic nature of customer demand, differences in production and transport costs and transport times between production plants in different regions. Finally, the model is applied to a case study. The results of numerical computations are presented. The implications of the model results on different fashion related product types and delivery strategies, as well as the model’s limitations and potentials for expansion, are discussed. Results indicate that the production planning model using conditional value at risk (CVaR as the risk measure performs robustly and provides flexibility in decision analysis between different scenarios.

7 CFR Appendix D to Subpart E of... - Alcohol Production Facilities Planning, Performing, Development and Project Control

Science.gov (United States)

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true Alcohol Production Facilities Planning, Performing... of Part 1980—Alcohol Production Facilities Planning, Performing, Development and Project Control (I..., without recourse to the Government, for the settlement and satisfaction of all contractual and...

OPEC production: Capital limitations, environmental movements may interfere with expansion plans

International Nuclear Information System (INIS)

Ismail, I.A.H.

1994-01-01

Obtaining capital is a critical element in the production expansion plans of OPEC member countries. Another issue that may impact the plans is the environmental taxes that may reduce the call on OPEC oil by 5 million b/d in 2000 and about 16 million b/d in the year 2010. This concluding part of a two-part series discusses the expansion possibilities of non-Middle East OPEC members, OPEC's capital requirements, and environmental concerns. Non-Middle East OPEC includes Algeria, Gabon, Indonesia, Libya, Nigeria, and Venezuela

Library orientation on videotape: production planning and administrative support.

Science.gov (United States)

Shedlock, J; Tawyea, E W

1989-01-01

New student-faculty-staff orientation is an important public service in a medical library and demands creativity, imagination, teaching skill, coordination, and cooperation on the part of public services staff. The Northwestern University Medical Library (NUML) implemented a video production service in the spring of 1986 and used the new service to produce an orientation videotape for incoming students, new faculty, and medical center staff. Planning is an important function in video production, and the various phases of outlining topics, drafting scripts, matching video sequences, and actual taping of video, voice, and music are described. The NUML orientation videotape demonstrates how reference and audiovisual services merge talent and skills to benefit the library user. Videotape production, however, cannot happen in a vacuum of good intentions and high ideals. This paper also presents the management support and cost analysis needed to make video production services a reality for use by public service departments.

Improving productivity and firm performance with enterprise resource planning

Science.gov (United States)

Beheshti, Hooshang M.; Beheshti, Cyrus M.

2010-11-01

Productivity is generally considered to be the efficient utilisation of organisational resources and is measured in terms of the efficiency of a worker, company or nation. Focusing on efficiency alone, however, can be harmful to the organisation's long-term success and competitiveness. The full benefits of productivity improvement measures are realised when productivity is examined from two perspectives: operational efficiency (output/input) of an individual worker or a business unit as well as performance (effectiveness) with regard to end user or customer satisfaction. Over the years, corporations have adopted new technology to integrate business activities in order to achieve both effectiveness and efficiency in their operations. In recent years, many firms have invested in enterprise resource planning (ERP) in order to integrate all business activities into a uniform system. The implementation of ERP enables the firm to reduce the transaction costs of the business and improve its productivity, customer satisfaction and profitability.

Combined heat and power production planning in a waste-to-energy plant on a short-term basis

International Nuclear Information System (INIS)

Touš, Michal; Pavlas, Martin; Putna, Ondřej; Stehlík, Petr; Crha, Lukáš

2015-01-01

In many cases, WtE (waste-to-energy) plants are CHP (combined heat and power) producers. They are often integrated into a central heating system and they also export electricity to the grid. Therefore, they have to plan their operation on a long-term basis (months, years) as well as on a short-term basis (hours, days). Simulation models can effectively support decision making in CHP production planning. In general, CHP production planning on a short-term basis is a challenging task for WtE plants. This article presents a simulation based support. It is demonstrated on an example involving a real WtE plant. Most of the models of relevant WtE sub-systems (boilers, steam turbine) are developed using operational data and applying linear regression and artificial neural network technique. The process randomness given mainly by fluctuating heating value of waste leads to uncertainty in a calculation of CHP production and a stochastic approach is appropriate. The models of the sub-systems are, therefore, extended of a stochastic part and Monte-Carlo simulation is applied. Compared to the current planning strategy in the involved WtE plant, the stochastic simulation based planning provides increased CHP production resulting in better net thermal efficiency and increased revenue. This is demonstrated through a comparison using real operational data. - Highlights: • Introduction of a stochastic model of a CHP production in a waste-to-energy plant. • An application of the model for the next day CHP production planning. • Better net thermal efficiency and therefore increased revenue achieved.

A New View at the Planning Marketing Popular Products: Exploratory Study Electronics Sector with Companies in Brazil.

Directory of Open Access Journals (Sweden)

Evange Elias Assis

2015-06-01

Full Text Available The increased consumption of appliance and electronic products by lower-income population represented a growth opportunity for companies in the sector. The overall objective of this paper is to investigate how appliance and electronic product manufacturers draw up their marketing planning for low-end products. An exploratory approach was taken in this study, comprising the literature review and the empirical research which was conducted in two stages by combining the qualitative and quantitative approaches. The study group comprised companies affiliated with National Association of Appliance and Electronic Product Manufacturers (ELETROS. Results indicate that in 87.5% of cases the marketing planning focuses on the product. The companies are concerned to differentiate the low-end products on the market mainly by design (87.5% and innovation (62.5%. Within this context, it seems that the opportunity for growth of the appliance and electronic product companies can be boosted when implementing specific marketing planning for low-end products. Innovation is needed in all processes from project design of the product to its distribution. 

Advance Planning of Form Properties in the Written Production of Single and Multiple Words

Science.gov (United States)

Damian, Markus F.; Stadthagen-Gonzalez, Hans

2009-01-01

Three experiments investigated the scope of advance planning in written production. Experiment 1 manipulated phonological factors in single word written production, and Experiments 2 and 3 did the same in the production of adjective-noun utterances. In all three experiments, effects on latencies were found which mirrored those previously…

Mixed-Integer Linear Programming approaches to shelf-life-integrated planning and scheduling in yoghurt production

NARCIS (Netherlands)

Lütke Entrup, M.; Günther, H.O.; Beek, van P.; Grunow, M.; Seiler, T.

2005-01-01

In the production of perishable products such as dairy, meat or bakery goods, the consideration of shelf life in production planning is of particular importance. Retail customers with relatively low inventory turns can benefit significantly from longer product shelf life as wastage and out-of-stock

75 FR 55776 - Request for Comments on Vaccine Production and Additional Planning for Future Possible Pandemic...

Science.gov (United States)

2010-09-14

... Production and Additional Planning for Future Possible Pandemic Influenza AGENCY: International Trade... additional planning for future possible pandemic influenza. DATES: Written comments must be submitted on or... influenza pandemic (see World Health Organization announcement of August 10, 2010) and the need to plan for...

Red-hot econimies, inflation throw cold water over Baltics' euro-plans

Index Scriptorium Estoniae

2005-01-01

Läti peaminister Aigars Kalvitis on seisukohal, et 2007. aastal ei liitu euroga ükski viimati EL-iga ühinenud riikidest. Lätis on Euroopa Liidu riikide seas kõrgeim inflatsioonitase. Tabel: Inflatsioon

USGS QA Plan: Certification of digital airborne mapping products

Science.gov (United States)

Christopherson, J.

2007-01-01

To facilitate acceptance of new digital technologies in aerial imaging and mapping, the US Geological Survey (USGS) and its partners have launched a Quality Assurance (QA) Plan for Digital Aerial Imagery. This should provide a foundation for the quality of digital aerial imagery and products. It introduces broader considerations regarding processes employed by aerial flyers in collecting, processing and delivering data, and provides training and information for US producers and users alike.

Determination of radiography optimum conditions for complex shape products by simplex planning method

International Nuclear Information System (INIS)

Kipnis, M.A.; Korsunskij, G.M.; Mironenko, A.F.

1984-01-01

It has been suggested that the optimum regime of radiography should be determined using the method of successive simplex planning, which can be convenient in the cases, when the result of testing can not be presented quantitatively. Besides, in this case there is no necessity in duplication of experiments, as even gross errors are automatically corrected with further simplex motion. A plan and results of experimental determination of the optimum regime of product radiography using the X-ray RUP-120-5-1 apparatus are presented. In the experiments described voltage, current intensity and radiography duration are varied. The quality of X-ray images is evaluated according to conventional ten-point scale, taking into account the quality of each projection. It has been established that application of simplex planning to determine regimes of X-ray radiography of different types of products permits to obtain high-quality roentgenograms with simultaneous decrease in the consumption of photomaterials and considerable decrease in the time of laboratory tests

Human Factors And Ergonomics In The Planning Of Production

DEFF Research Database (Denmark)

Jensen, Per Langå

2002-01-01

For year’s integration of ergonomics into the planning of new production processes has been an ideal for regulating agencies supported by ergonomic experts. But the ideal appears to be difficult to live up to. A development of tools both by agencies and by groups of researchers has been seen...... of organizational conditions for giving ergonomics a stronger position in the firm. Ergonomists have to tackle these issues, but it implies a new understanding of their roles, which goes beyond the traditional discussion of expert versus facilitator. The paper is based on an evaluation of a Swedish research......-programme of a new approach to intervention studies on musculosceletaldiseases, on a major Danish research programme on integrating ergonomics (working environment) into the planning activities of the enterprises and on discussions with the staff of the Danish mandatory occupational health and safety services...

Function of the EGR-1/TIS8 radiation inducible promoter in a minimal HSV-1 amplicon system

International Nuclear Information System (INIS)

Spear, M.A.; Sakamoto, K.M.; Herrlinger, U.; Pechan, P.; Breakefield, X.O.

1997-01-01

Purpose: To evaluate function of the EGR-1/TIS8 promoter region in minimal HSV-1 amplicon system in order to determine the feasibility of using the system to regulate vector replication with radiation. Materials and Methods: A 600-base pair 5' upstream region of the EGR-1 promoter linked to chloramphenicol acetyltransferase (CAT) was recombined into a minimal HSV-1 amplicon vector system (pONEC). pONEC or a control plasmid was transfected into U87 glioma cells using the Lipofectamine method. Thirty-six hours later one aliquot of cells from each transfection was irradiated to a dose of 20 Gy and another identical aliquot served as a control. CAT activity was assayed 8 hours after irradiation. Results: pONEC transfected cells irradiated with 20 Gy demonstrated 2.0 fold increase in CAT activity compared to non-irradiated cells. Cells transfected with control plasmid showed no change in CAT activity. Unirradiated pONEC cells had CAT activity 1.3 times those transfected with control plasmid. Conclusion: We have previously created HSV-1 gene therapy amplicon vector systems which allow virus-amplicon interdependent replication, with the intent of regulating replication. The above data demonstrates that a minimal amplicon system will allow radiation dependent regulation by the EGR-1 promoter, thus indicating the possibility of using this system to regulate onsite, spatially and temporally regulated vector production. Baseline CAT activity was higher and relative induction lower than other reported expression constructs, which raises concern for the ability of the system to produce a differential in transcription levels sufficient for this purpose. This is possibly the result of residual promoter/enhancer elements remaining in the HSV-1 sequences. We are attempting to create constructs lacking these elements. Addition of secondary promoter sequences may also be of use. We are also currently evaluating the efficacy of the putative IEX-1 radiation inducible promoter region in

Effects of cognitive impairment on prosodic parameters of speech production planning in multiple sclerosis.

Science.gov (United States)

De Looze, Céline; Moreau, Noémie; Renié, Laurent; Kelly, Finnian; Ghio, Alain; Rico, Audrey; Audoin, Bertrand; Viallet, François; Pelletier, Jean; Petrone, Caterina

2017-05-24

Cognitive impairment (CI) affects 40-65% of patients with multiple sclerosis (MS). CI can have a negative impact on a patient's everyday activities, such as engaging in conversations. Speech production planning ability is crucial for successful verbal interactions and thus for preserving social and occupational skills. This study investigates the effect of cognitive-linguistic demand and CI on speech production planning in MS, as reflected in speech prosody. A secondary aim is to explore the clinical potential of prosodic features for the prediction of an individual's cognitive status in MS. A total of 45 subjects, that is 22 healthy controls (HC) and 23 patients in early stages of relapsing-remitting MS, underwent neuropsychological tests probing specific cognitive processes involved in speech production planning. All subjects also performed a read speech task, in which they had to read isolated sentences manipulated as for phonological length. Results show that the speech of MS patients with CI is mainly affected at the temporal level (articulation and speech rate, pause duration). Regression analyses further indicate that rate measures are correlated with working memory scores. In addition, linear discriminant analysis shows the ROC AUC of identifying MS patients with CI is 0.70 (95% confidence interval: 0.68-0.73). Our findings indicate that prosodic planning is deficient in patients with MS-CI and that the scope of planning depends on patients' cognitive abilities. We discuss how speech-based approaches could be used as an ecological method for the assessment and monitoring of CI in MS. © 2017 The British Psychological Society.

Soedra's ecological forest management plans. Effects on production and economy

International Nuclear Information System (INIS)

Viklund, E.

1998-01-01

In 1995 SOEDRA Skog, Sweden's largest forest owners association, started making ecological forest management plans, Groena skogsbruksplaner. The ecological forest management plans are divided into different compartments in which the management is adapted to the present ecological conditions. The stands are divided into four different categories depending on the different values of nature conservation. The object of this study was to find an easy method to quantify and describe the effects of nature conservation on economy and forest production in SOEDRA:s ecological forest management plans. The developed and purposed method, called PLAN-metoden, does not consider the interests, measures beyond the period of the plan, or losses due to snow or wind. It calculates the difference between the purposed measures in the ecological management plan and an alternative with management according to the requirements of the present Forestry Act. The economic effects of nature conservation varies between a net profit of 0,3% and a cost of 9,1% when calculated with the cash-flow method. The average decrease of possible cutting of merchantable timber was 11,3% and varies between 3,1 and 32,9%. The average decrease of cutting possibilities was 12,9% and varies between a decrease of 0,7% and a decrease of 28,3% when calculated with a present value method. Mainly mature, well-stocked compartments, which are considered not to be managed in the future, give rise to high costs. Properties with unprofitable thinnings and costly scarification, regeneration and cleaning seem to be favoured by the nature conservation in the plans. The Ecological management plans are expected to be of great importance to the members of SOEDRA. The interest in nature conservation is larger than that of economical issues. In order to avoid unsatisfactory results the planning should be accomplished in close personal contact with the forest owner Examination paper 1998-1. 21 refs, 2 figs, 39 tabs

Anal canal carcinoma: Early-stage tumors ≤10 mm (T1 or Tis): Therapeutic options and original pattern of local failure after radiotherapy

International Nuclear Information System (INIS)

Ortholan, Cecile; Ramaioli, Alain; Peiffert, Didier; Lusinchi, Antoine; Romestaing, Pascale; Chauveinc, Laurent; Touboul, Emmanuel; Peignaux, Karine; Bruna, Antoine; La Roche, Guy de; Lagrange, Jean-Leon; Alzieu, Christian; Gerard, Jean Pierre

2005-01-01

Purpose: To investigate the clinical history, management, and pattern of recurrence of very early-stage anal canal cancer in a French retrospective survey. Methods: The study group consisted of 69 patients with Stage Tis and T1 anal canal carcinoma ≤1 cm treated between 1990 and 2000 (12 were in situ, 57 invasive, 66 Stage N0, and 3 Stage N1). The median patient age was 67 years (range, 27-83 years). Of the 69 patients, 66 received radiotherapy (RT) and 3 with in situ disease were treated by local excision alone without RT. Twenty-six patients underwent local excision before RT (12 with negative and 14 with positive surgical margins). Of the 66 patients who underwent RT, 8 underwent brachytherapy alone (median dose, 55 Gy), 38 underwent external beam RT (median dose, 45 Gy) plus a brachytherapy boost (median boost dose, 20 Gy), and 20 underwent external beam RT alone (median dose, 55 Gy). Results: Of the 69 patients, 68 had initial local control. Of the 66 patients treated by RT, 6 developed local recurrence at a median interval of 50 months (range, 13-78 months). Four patients developed local failure outside the initial tumor bed. Of the 3 patients with Tis treated by excision alone, 1 developed local recurrence. No relation was found among prior excision, dose, and local failure. The 5-year overall survival, colostomy-free survival, and disease-free survival rate was 94%, 85%, and 89%, respectively. The rate of late complications (Grade 1-3) was 28% and was 14% for those who received doses <60 Gy and 37% for those who received doses of ≥60 Gy (p = 0.04). Conclusion: Most recurrences occurred after a long disease-free interval after treatment and often outside the initial tumor site. These small anal cancers could be treated by RT using a small volume and moderate dose (40-50 Gy for subclinical lesions and 50-60 Gy for T1)

Supply Network Planning for New Product Market Entry in the Pharmaceutical Industry

DEFF Research Database (Denmark)

Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin

2011-01-01

uncertainty and the risk of a forced label change and includes solution robustness. While considering limited shelf life of the drug, the supply of packaging material and outsourcing, the objective of our model is to reduce supply chain cost including lost peak sales from delayed market entry....... planning before and during the market entry of the drug after the drug has been approved. Production of the active pharmaceutical ingredient [API] is characterized by long change-over times due to cleaning requirements. Production planning is long term, multiple batches of each drug are produced...... industry, reimbursement negotiations have to be carried out before a drug can be marketed. These negotiations both necessitate time phasing market entries and introduce a series of uncertainties e.g. varying allowed price and awarded subsidy. Also if the label is not approved for marketing, all packaged...

Increasing Student Interest and Comprehension of Production Planning and Control and Operations Performance Measurement Concepts Using a Production Line Game

Science.gov (United States)

Cox, James F., III; Walker, Edward D., II

2005-01-01

Production planning and control (PPC) systems and operations performance measures are topics that students generally find both boring and difficult to understand. In the article, the authors present a production line game that they have found to be an effective tool to increase student interest in the topics as well as student comprehension. The…

Effective production planning for purchased part under long lead time and uncertain demand: MRP Vs demand-driven MRP

Science.gov (United States)

Shofa, M. J.; Moeis, A. O.; Restiana, N.

2018-04-01

MRP as a production planning system is appropriate for the deterministic environment. Unfortunately, most production systems such as customer demands are stochastic, so that MRP is inappropriate at the time. Demand-Driven MRP (DDMRP) is new approach for production planning system dealing with demand uncertainty. The objective of this paper is to compare the MRP and DDMRP for purchased part under long lead time and uncertain demand in terms of average inventory levels. The evaluation is conducted through a discrete event simulation with the long lead time and uncertain demand scenarios. The next step is evaluating the performance of DDMRP by comparing the inventory level of DDMRP with MRP. As result, DDMRP is more effective production planning than MRP in terms of average inventory levels.

Critical care medicine as a distinct product line with substantial financial profitability: the role of business planning.

Science.gov (United States)

Bekes, Carolyn E; Dellinger, R Phillip; Brooks, Daniel; Edmondson, Robert; Olivia, Christopher T; Parrillo, Joseph E

2004-05-01

As academic health centers face increasing financial pressures, they have adopted a more businesslike approach to planning, particularly for discrete "product" or clinical service lines. Since critical care typically has been viewed as a service provided by a hospital, and not a product line, business plans have not historically been developed to expand and promote critical care. The major focus when examining the finances of critical care has been cost reduction, not business development. We hypothesized that a critical care business plan can be developed and analyzed like other more typical product lines and that such a critical care product line can be profitable for an institution. In-depth analysis of critical care including business planning for critical care services. Regional academic health center in southern New Jersey. None. As part of an overall business planning process directed by the Board of Trustees, the critical care product line was identified by isolating revenue, expenses, and profitability associated with critical care patients. We were able to identify the major sources ("value chain") of critical care patients: the emergency room, patients who are admitted for other problems but spend time in a critical care unit, and patients transferred to our intensive care units from other hospitals. The greatest opportunity to expand the product line comes from increasing the referrals from other hospitals. A methodology was developed to identify the revenue and expenses associated with critical care, based on the analysis of past experience. With this model, we were able to demonstrate a positive contribution margin of dollar 7 million per year related to patients transferred to the institution primarily for critical care services. This can be seen as the profit related to the product line segment of critical care. There was an additional positive contribution margin of dollar 5.8 million attributed to the critical care portion of the hospital stay of

Model business plan for a sterile insect production facility

International Nuclear Information System (INIS)

2008-01-01

For over 50 years the sterile insect technique (SIT) is a pest control strategy which has been used for eradication, and more recently for suppression, containment and prevention, of unwanted insect pest populations. Examples of successful applications of SIT, almost always applied in conjunction with other control methods in an area-wide integrated approach, are available from around the world. The development and application of SIT has relied overwhelmingly on public or donor initiative and funding throughout its history, although the private sector has always been involved as participants, cooperators or partners in funding. The demand for SIT, and therefore the market for sterile insects, has increased in recent years. This increase coincides with the introduction of new pests through the expansion of global trade and, at the same time, widespread pressure to find alternatives to pesticides. Recent improvements in the technology supporting SIT facilitate its application and suggest lower costs can be achieved. The conditions are therefore met for a greater commercialization of the technique to bring it in line with other pest control approaches that are fully integrated into a market approach. Several challenges arise, however, in pursuing sterile insect production as a commercial venture, ranging from intellectual property protection to pricing of the product. Routine insurance requirements, for instance, are complicated by the biological aspects of the business. This report is aimed at facilitating private sector involvement in the production of sterile insects for use in pest control. It provides guidelines and tools to support the development of specific business plans for a new SIT venture. By providing an international perspective on such issues as initial capital costs and recurring operational expenditures for a sterile insect facility, it may be used to evaluate the feasibility of proceeding with the construction or expansion of a sterile insect

Multiperiod planning tool for multisite pig production systems.

Science.gov (United States)

Nadal-Roig, E; Plà, L M

2014-09-01

This paper presents a multiperiod planning tool for multisite pig production systems based on Linear Programming (LP). The aim of the model is to help pig managers of multisite systems in making short-term decisions (mainly related to pig transfers between farms and batch management in fattening units) and mid-term or long-term decisions (according to company targets and expansion strategy). The model skeleton follows the structure of a three-site system that can be adapted to any multisite system present in the modern pig industry. There are three basic phases, namely, piglet production, rearing pigs, and fattening. Each phase involves a different set of farms; therefore, transportation between farms and delivering of pigs to the abattoir are under consideration. The model maximizes the total gross margin calculated from the income of sales to the abattoir and the production costs over the time horizon considered. Production cost depends on each type of farm involved in the process. Parameters like number of farms per phase and distance, farm capacity, reproduction management policies, feeding and veterinary expenses, and transportation costs are taken into account. The model also provides a schedule of transfers between farms in terms of animals to be transported and number of trucks involved. The use of the model is illustrated with a case study based on a real instance of a company located in Catalonia (Spain).

Optimization of the production plan and risk control in Third Qinshan Nuclear Power Co.,Ltd

International Nuclear Information System (INIS)

Zhou Jun

2009-01-01

Some optimized and improved measures have been taken in Third Qinshan Nuclear Power Co., Ltd. (TQNPC) to optimize the routine production plan management, strengthen the maintenance work risk analysis, and improve the plan execution capability. Which involve unified management of generation, refueling, periodic test and maintenance plans; simplifying the defect scale and reducing the intermediate link of defect treatment; intensifying the appraisal on plan execution and adopting star performance evaluation and merit rating measures. In this paper, the above-mentioned improvement and optimization are introduced comprehensively and systematically. (authors)

Multi-annual planning of investments for heat production. 2009 - 2020 period

International Nuclear Information System (INIS)

2005-01-01

A new Multi-annual Planning of Investments (PPI) for heat production in France has been realized in order to meet the conclusions of the Grenelle Environnement Forum for a better energy efficiency and a larger use of renewable energies. Based on quantitative data (the increase in heat production will reach more than 10 Mtoe by 2020), potential objectives have been assessed for the various heat production sources and techniques: wood, biomass (for buildings, district heating, industry and processes, cogeneration), deep and intermediary geothermal energy, individual heat pumps, individual and collective heat solar systems, biogas, etc. These objectives are said to be ambitious but reachable if every sources and techniques are thoroughly exploited

Realizing block planning concepts in make-and-pack production using MILP modelling and SAP APO

DEFF Research Database (Denmark)

Günther, H.O.; Grunow, M.; Neuhaus, U.

2006-01-01

of a major producer of hair dyes as a case study. We present two different implementations of the block planning concept. One utilizes the Production Planning/Detailed Scheduling module of the SAP APO© software. The other approach is based on a mixed-integer linear programming formulation. In contrast...

Implementation of Logic Flow in Planning and Production Control

Directory of Open Access Journals (Sweden)

Ulewicz Robert

2016-03-01

Full Text Available The article presents the results of analysis, the use of continuous flow of logic at the stage of production planning and control of the company producing furniture. The concept of continuous flow tends to regulate the flow of materials in a manner that provides the shortest flow path without unnecessary activities (Muda is a Japanese word meaning waste, a constant takt and defined throughput at constant resource requirements for the so-called transfer of material through the whole process. In the study Glenday’d sieve method was used to identify the correct area, which requires the value stream mapping, and areas called excessive complexity, which do not provide added value. The use of Glenday’s sieve method made it possible to identify areas in which it must be improve production capacity.

Terminal Differentiation of Adult Hippocampal Progenitor Cells Is a Step Functionally Dissociable from Proliferation and Is Controlled by Tis21, Id3 and NeuroD2

Directory of Open Access Journals (Sweden)

Laura Micheli

2017-07-01

Full Text Available Cell proliferation and differentiation are interdependent processes. Here, we have asked to what extent the two processes of neural progenitor cell amplification and differentiation are functionally separated. Thus, we analyzed whether it is possible to rescue a defect of terminal differentiation in progenitor cells of the dentate gyrus, where new neurons are generated throughout life, by inducing their proliferation and/or their differentiation with different stimuli appropriately timed. As a model we used the Tis21 knockout mouse, whose dentate gyrus neurons, as demonstrated by us and others, have an intrinsic defect of terminal differentiation. We first tested the effect of two proliferative as well as differentiative neurogenic stimuli, one pharmacological (fluoxetine, the other cognitive (the Morris water maze (MWM training. Both effectively enhanced the number of new dentate gyrus neurons produced, and fluoxetine also reduced the S-phase length of Tis21 knockout dentate gyrus progenitor cells and increased the rate of differentiation of control cells, but neither factor enhanced the defective rate of differentiation. In contrast, the defect of terminal differentiation was fully rescued by in vivo infection of proliferating dentate gyrus progenitor cells with retroviruses either silencing Id3, an inhibitor of neural differentiation, or expressing NeuroD2, a proneural gene expressed in terminally differentiated dentate gyrus neurons. This is the first demonstration that NeuroD2 or the silencing of Id3 can activate the differentiation of dentate gyrus neurons, complementing a defect of differentiation. It also highlights how the rate of differentiation of dentate gyrus neurons is regulated genetically at several levels and that a neurogenic stimulus for amplification of neural stem/progenitor cells may not be sufficient in itself to modify this rate.

Adherence to tobramycin inhaled powder vs inhaled solution in patients with cystic fibrosis: analysis of US insurance claims data

Directory of Open Access Journals (Sweden)

Hamed K

2017-04-01

Full Text Available Kamal Hamed,1 Valentino Conti,2 Hengfeng Tian,1 Emil Loefroth3 1Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 2Novartis Global Service Center, Dublin, Ireland; 3Novartis Sverige AB, Täby, Sweden Purpose: Tobramycin inhalation powder (TIP, the first dry-powder inhaled antibiotic for pulmonary Pseudomonas aeruginosa infection, is associated with reduced treatment burden, increased patient satisfaction, and higher self-reported adherence for cystic fibrosis (CF patients. We compared adherence in CF patients newly treated with TIP with those newly treated with the traditional tobramycin inhalation solution (TIS, using US insurance claims data.Patients and methods: From the Truven MarketScan® database, we identified CF patients chronically infected with P. aeruginosa who had been prescribed TIP between May 1, 2013 to December 31, 2014, or TIS between September 1, 2010 to April 30, 2012 with at least 12 months of continuous medical and pharmacy benefits prior to and following prescription. TIP and TIS adherence levels were assessed.Results: A total of 145 eligible patients were identified for the TIP cohort and 306 for the TIS cohort. Significant differences in age distribution (25.0 vs 21.9 years for TIP vs TIS, respectively, P=0.017, type of health plan (P=0.014, employment status (72.4% vs 63.4% of TIP vs TIS patients in full-time employment, P=0.008, and some comorbidities were observed between the two cohorts. Although a univariate analysis found no significant differences between TIP and TIS (odds ratio [OR] 1.411, 95% confidence interval [CI] 0.949–2.098, TIP was moderately associated with higher adherence levels compared with TIS in a multivariable analysis, once various demographic and clinical characteristics were adjusted for. These included geographic location (OR: 1.566, CI: 1.016–2.413 and certain comorbidities.Conclusion: This study of US patient data supports previous findings that TIP is associated with better

Methods and Algorithms for Economic MPC in Power Production Planning

DEFF Research Database (Denmark)

Sokoler, Leo Emil

in real-time. A generator can represent a producer of electricity, a consumer of electricity, or possibly both. Examples of generators are heat pumps, electric vehicles, wind turbines, virtual power plants, solar cells, and conventional fuel-fired thermal power plants. Although this thesis is mainly...... concerned with EMPC for minutes-ahead production planning, we show that the proposed EMPC scheme can be extended to days-ahead planning (including unit commitment) as well. The power generation from renewable energy sources such as wind and solar power is inherently uncertain and variable. A portfolio...... design an algorithm based on the alternating direction method of multipliers (ADMM) to solve input-constrained OCPs with convex objective functions. The OCPs that occur in EMPC of dynamically decoupled subsystems, e.g. power generators, have a block-angular structure. Subsystem decomposition algorithms...

Integrate Product Planning Process of OKP Companies in the Cloud Manufacturing Environment

OpenAIRE

Zheng , Pai; Xu , Xun; Xie , Sheng ,

2015-01-01

Part 8: Cloud-Based Manufacturing; International audience; In today’s competitive market, OKP companies operate in the “engineer-to-order” business mode, whereby analysing the “voice of customer” promptly and accurately in the early design stage determines the success of product development. However, OKP companies have limited resources. They may not be able to afford the cost of the complicated Quality Function Deployment (QFD) product planning process, nor can they obtain abundant CRs infor...

[The Teratology Information Service: medicines during pregnancy and lactation].

Science.gov (United States)

de Vries, Loes C; de Swart, Irene W; van Puijenbroek, Eugène P

2016-01-01

Many women use medication during pregnancy. Both the healthcare professional and the pregnant woman often have many questions about the possible adverse effects of the medication that are not always answered in the product information. The Teratology Information Service (TIS), a part of the Netherlands Pharmacovigilance Centre Lareb, is a centre of expertise in the field of the safety of medication use and other external influences during spermatogenesis, pregnancy and lactation. The TIS collects, interprets, and disseminates information that can contribute to patient care. Healthcare professionals can contact the TIS for information and individual risk assessments. In this article we discuss the background and positioning of the TIS, the characteristics of telephone consultations, the collection of data and the considerations that are important for the use of medication during pregnancy and lactation.

The effect of workload constraints in linear programming models for production planning

NARCIS (Netherlands)

Jansen, M.M.; Kok, de A.G.; Adan, I.J.B.F.

2011-01-01

Linear programming (LP) models for production planning incorporate a model of the manufacturing system that is necessarily deterministic. Although these deterministic models are the current state-of-the-art, it should be recognized that they are used in an environment that is inherently stochastic.

The effect of workload constraints in mathematical programming models for production planning

NARCIS (Netherlands)

Jansen, M.M.; Kok, de A.G.; Adan, I.J.B.F.

2010-01-01

Linear and mixed integer programming models for production planning incorporate a model of the manufacturing system that is necessarily deterministic. Although these eterministic models are the current-state-of-art, it should be recognized that they are used in an environment that is inherently

Integrated load distribution and production planning in series-parallel multi-state systems with failure rate depending on load

International Nuclear Information System (INIS)

Nourelfath, Mustapha; Yalaoui, Farouk

2012-01-01

A production system containing a set of machines (also called components) arranged according to a series-parallel configuration is addressed. A set of products must be produced in lots on this production system during a specified finite planning horizon. This paper presents a method for integrating load distribution decisions, and tactical production planning considering the costs of capacity change and the costs of unused capacity. The objective is to minimize the sum of capacity change costs, unused capacity costs, setup costs, holding costs, backorder costs, and production costs. The main constraints consist in satisfying the demand for all products over the entire horizon, and in not exceeding available repair resource. The production series-parallel system is modeled as a multi-state system with binary-state components. The proposed model takes into account the dependence of machines' failure rates on their load. Universal generating function technique can be used in the optimization algorithm for evaluating the expected system production rate in each period. We show how the formulated problem can be solved by comparing the results of several multi-product lot-sizing problems with capacity associated costs. The importance of integrating load distribution decisions and production planning is illustrated through numerical examples.

Learning Outcomes in Vocational Education: A Business Plan Development by Production-Based Learning Model Approach

Science.gov (United States)

Kusumaningrum, Indrati; Hidayat, Hendra; Ganefri; Anori, Sartika; Dewy, Mega Silfia

2016-01-01

This article describes the development of a business plan by using production-based learning approach. In addition, this development also aims to maximize learning outcomes in vocational education. Preliminary analysis of curriculum and learning and the needs of the market and society become the basic for business plan development. To produce a…

Feed Materials Production Center waste management plan (Revision to NLCO-1100, R.6)

International Nuclear Information System (INIS)

Watts, R.E.; Allen, T.; Castle, S.A.; Hopper, J.P.; Oelrich, R.L.

1986-01-01

In the process of producing uranium metal products used in Department of Energy (DOE) defense programs at other DOE facilities, various types of wastes are generated at the Feed Materials Production Center (FMPC). Process wastes, both generated and stored, are discussed in the Waste Management Plan and include low-level radioactive waste (LLW), mixed hazardous/radioactive waste, and sanitary/industrial waste. Scrap metal waste and wastes requiring special remediation are also addressed in the Plan. The Waste Management Plan identifies the comprehensive programs developed to address safe storage and disposition of all wastes from past, present, and future operations at the FMPC. Waste streams discussed in this Plan are representative of the wastes generated and waste types that concern worker and public health and safety. Budgets and schedules for implementation of waste disposition are also addressed. The waste streams receiving the largest amount of funding include LLW approved for shipment by DOE/ORO to the Nevada Test Site (NTS) (MgF 2 , slag leach filter cake, and neutralized raffinate); remedial action wastes (waste pits, K-65 silo waste); thorium; scrap metal (contaminated and noncontaminated ferrous and copper scrap); construction rubble and soil generated from decontamination and decommissioning of outdated facilities; and low-level wastes that will be handled through the Low-Level Waste Processing and Shipping System (LLWPSS). Waste Management milestones are also provided. The Waste Management Plan is divided into eight major sections: Introduction; Site Waste and Waste Generating Process; Strategy; Projects and Operations; Waste Stream Budgets; Milestones; Quality Assurance for Waste Management; and Environmental Monitoring Program

Planning Risk-Based SQC Schedules for Bracketed Operation of Continuous Production Analyzers.

Science.gov (United States)

Westgard, James O; Bayat, Hassan; Westgard, Sten A

2018-02-01

To minimize patient risk, "bracketed" statistical quality control (SQC) is recommended in the new CLSI guidelines for SQC (C24-Ed4). Bracketed SQC requires that a QC event both precedes and follows (brackets) a group of patient samples. In optimizing a QC schedule, the frequency of QC or run size becomes an important planning consideration to maintain quality and also facilitate responsive reporting of results from continuous operation of high production analytic systems. Different plans for optimizing a bracketed SQC schedule were investigated on the basis of Parvin's model for patient risk and CLSI C24-Ed4's recommendations for establishing QC schedules. A Sigma-metric run size nomogram was used to evaluate different QC schedules for processes of different sigma performance. For high Sigma performance, an effective SQC approach is to employ a multistage QC procedure utilizing a "startup" design at the beginning of production and a "monitor" design periodically throughout production. Example QC schedules are illustrated for applications with measurement procedures having 6-σ, 5-σ, and 4-σ performance. Continuous production analyzers that demonstrate high σ performance can be effectively controlled with multistage SQC designs that employ a startup QC event followed by periodic monitoring or bracketing QC events. Such designs can be optimized to minimize the risk of harm to patients. © 2017 American Association for Clinical Chemistry.

EU project CODE-TEN, Technical reports (deliverables, working papers), see: www.iccr.co.at/transpor/index.htm

DEFF Research Database (Denmark)

Leleur, Steen; Moshøj, Claus Rehfeld; Kronbak, Jacob

1998-01-01

Methodology for transport infrastructure corridor planning: Baseline methodology DECODE, transport information system (TIS) database, case study corridor IX: Oldenburg - Copenhagen - Stockholm - Helsinki - St. Petersburg - Moscow, formulation of decision support system...

Implementation of Capacity Planning Agent of Demand Responsive Planning Framework : Master’s Thesis in Production Engineering of The Royal Institute of Technology

OpenAIRE

Juhong, Nirut

2013-01-01

This master’s thesis is conducted as a conclusion of Master degree of Science in Production Engineering and Management at The Royal Institute of Technology. The focus of this thesis work is to implement a Capacity planning agent. Nowadays, companies need to adapt themselves to be as responsive to customers’ demand as possible. However, the responsiveness is usually limited by the fixed capacity of the production. Evolvable Production System (EPS), motivated by the limitation mentioned above, ...

Integrated Strategic Planning of Global Production Networks and Financial Hedging under Uncertain Demands and Exchange Rates

Directory of Open Access Journals (Sweden)

Achim Koberstein

2013-11-01

Full Text Available In this paper, we present a multi-stage stochastic programming model that integrates financial hedging decisions into the planning of strategic production networks under uncertain exchange rates and product demands. This model considers the expenses of production plants and the revenues of markets in different currency areas. Financial portfolio planning decisions for two types of financial instruments, forward contracts and options, are represented explicitly by multi-period decision variables and a multi-stage scenario tree. Using an illustrative example, we analyze the impact of exchange-rate and demand volatility, the level of investment expenses and interest rate spreads on capacity location and dimensioning decisions. In particular, we show that, in the illustrative example, the exchange-rate uncertainty cannot be completely eliminated by financial hedging in the presence of demand uncertainty. In this situation, we find that the integrated model can result in better strategic planning decisions for a risk-averse decision maker compared to traditional modeling approaches.

Effect of Thin Prep® imaging system on laboratory rate and relative sensitivity of atypical squamous cells, high-grade squamous intraepithelial lesion not excluded and high-grade squamous intraepithelial lesion interpretations

Directory of Open Access Journals (Sweden)

Brooke R Koltz

2013-01-01

Full Text Available Introduction: Automated screening of Thin Prep ® Papanicolaou Tests has become increasingly common in clinical practice. Increased productivity has initiated laboratory use of the Thin Prep ® Imaging System (TIS. Increased sensitivity is a potential additional benefit of TIS. Published studies have shown an increase in discovery of dysplastic cells. This study evaluates the effect of TIS on the incidence of atypical squamous cells high-grade squamous intraepithelial lesion not excluded (ASC-H and high-grade squamous intraepithelial lesion (HGSIL results on Thin Prep ® Pap Tests by comparing TIS-assisted and manual screening findings and the diagnoses on subsequent follow-up in a screening population over a 1-year time period. Materials and Methods: A compilation of all ASC-H and HGSIL cases was prepared by conducting a computerized search over a 1-year period (7/06-6/07. The accumulated cases include Thin Prep Pap tests that were both TIS and manually screened. Follow-up results of cytologic and histologic cervical specimens were obtained for a time period extending to 2010. Interpretation utilizing TIS was in place 10 months prior to the study′s initiation. Results: During the study period 70,522 Pap tests were performed in our laboratory. One third (33% of Pap tests were screened with assistance of TIS. Manual screening was performed on 47,380 Pap tests of which 153 (0.32% were interpreted as ASC-H and 164 (0.35% were interpreted as HGSIL. During the same time period automated screening (TIS was performed on 23,111 Pap tests. Interpretation of 62 (0.27% cases provided an ASC-H result, while 71 (0.31% were HGSIL. Follow-up cervical dysplasia by colposcopic biopsy and cone biopsy was distributed proportionally between TIS and manual screening for both ASC-H and HGSIL categories. Cervical intraepithelial neoplasia (CIN II/III was identified on follow-up biopsy of 41% TIS cases and 45% manually screened cases for ASC-H. In the HGSIL subset 71

Uranium Mill Tailings Remedial Action Project: Cost Reduction and Productivity Improvement Program Project Plan

International Nuclear Information System (INIS)

1991-11-01

The purpose of the Cost Reduction/Productivity Improvement Program Plan is to formalize and improve upon existing efforts to control costs which have been underway since project inception. This program plan has been coordinated with the Department of Energy (DOE) Office of Environmental Management (EM) and the DOE Field Office, Albuquerque (AL). It incorporates prior Uranium Mill Tallings Remedial Action (UMTRA) Project Office guidance issued on the subject. The opportunities for reducing cosh and improving productivity are endless. The CR/PIP has these primary objectives: Improve productivity and quality; heighten the general cost consciousness of project participants, at all levels of their organizations; identify and implement specific innovative employee ideas that extend beyond what is required through existing processes and procedures; emphasize efforts that create additional value for the money spent by maintaining the project Total Estimated Cost (TEC) at the lowest possible level

To plan or not to plan: Does planning for production remove facilitation from associative priming?

Science.gov (United States)

Jongman, Suzanne R; Meyer, Antje S

2017-11-01

Theories of conversation propose that in order to have smooth transitions from one turn to the next, speakers already plan their response while listening to their interlocutor. Moreover, it has been argued that speakers align their linguistic representations (i.e. prime each other), thereby reducing the processing costs associated with concurrent listening and speaking. In two experiments, we assessed how identity and associative priming from spoken words onto picture naming were affected by a concurrent speech planning task. In a baseline (no name) condition, participants heard prime words that were identical, associatively related, or unrelated to target pictures presented two seconds after prime onset. Each prime was accompanied by a non-target picture and followed by its recorded name. The participant did not name the non-target picture. In the plan condition, the participants first named the non-target picture, instead of listening to the recording, and then the target. In Experiment 1, where the plan- and no-plan conditions were tested between participants, priming effects of equal strength were found in the plan and no-plan condition. In Experiment 2, where the two conditions were tested within participants, the identity priming effect was maintained, but the associative priming effect was only seen in the no-plan but not in the plan condition. In this experiment, participant had to decide at the onset of each trial whether or not to name the non-target picture, rendering the task more complex than in Experiment 1. These decision processes may have interfered with the processing of the primes. Thus, associative priming can take place during speech planning, but only if the cognitive load is not too high. Copyright © 2017 Elsevier B.V. All rights reserved.

Optimizing production and imperfect preventive maintenance planning's integration in failure-prone manufacturing systems

International Nuclear Information System (INIS)

Aghezzaf, El-Houssaine; Khatab, Abdelhakim; Tam, Phuoc Le

2016-01-01

This paper investigates the issue of integrating production and maintenance planning in a failure-prone manufacturing system. It is assumed that the system's operating state is stochastically predictable, in terms of its operating age, and that it can accordingly be preventively maintained during preplanned periods. Preventive maintenance is assumed to be imperfect, that is when performed, it brings the manufacturing system to an operating state that lies between ‘as bad as old’ and ‘as good as new’. Only an overhauling of the system brings it to a ‘as good as new’ operating state again. A practical integrated production and preventive maintenance planning model, that takes into account the system's manufacturing capacity and its operational reliability state, is developed. The model is naturally formulated as a mixed-integer non-linear optimization problem, for which an extended mixed-integer linear reformulation is proposed. This reformulation, while it solves the proposed integrated planning problem to optimality, remains quite demanding in terms of computational time. A fix-and-optimize procedure, that takes advantage of some properties of the original model, is then proposed. The reformulation and the fix-and-optimize procedure are tested on some test instances adapted from those available in the literature. The results show that the proposed fix-and-optimize procedure performs quite well and opens new research direction for future improvements. - Highlights: • Integration of production planning and imperfect preventive maintenance is explored. • Imperfect maintenance is modeled using a fitting age reduction hybrid hazard rate. • A practical approximate optimization model for this integration is proposed. • The resulting naturally MINL optimization model is reformulated and solved as a MILP. • An effective fix-and-optimize procedure is proposed for large instances of this MILP.

Applied Railway Optimization in Production Planning at DSB-S-tog - Tasks, Tools and Challenges

DEFF Research Database (Denmark)

Clausen, Jens

2007-01-01

these conflicting goals. S-tog has therefore on the strategic level decided to use software with optimization capabilities in the planning processes. We describe the current status for each activity using optimization or simulation as a tool: Timetable evaluation, rolling stock planning, and crew scheduling...... to the customers, and has concurrently been met with demands for higher efficiency in the daily operation. The plans of timetable, rolling stock and crew must hence allow for a high level of customer service, be efficient, and be robust against disturbances of operations. It is a highly non-trivial task to meet....... In addition we describe on-going efforts in using mathematical models in activities such as timetable design and work-force planning. We also identify some organizatorial key factors, which have paved the way for extended use of optimization methods in railway production planning....

Unit Link insurance product catches on in Latvia, finally

Index Scriptorium Estoniae

2005-01-01

Lätis tuleb turule uus elukindlustuse teenus, mille kaudu on võimalik kindlustuslepinguid siduda investeerimisfondidega. Eesti, Läti ja Leedu kindlustusturust. Tabel: Eesti elukindlustus ettevõtted : Eesti mitteelukindlustus ettevõtted

Advance Planning, Programming and Production Control as key Activities Now the Environmental Education

Directory of Open Access Journals (Sweden)

Geraldo Cardoso de Oliveira Neto

2015-06-01

Full Text Available This work addresses the evolution of Planning, Programming and Control of Production (PPCP as essential activities of the company towards the insertion of environmental education. The approach is based on an exploratory research and a critical bibliographic revision. Two main objectives were established: i a new way of production organization, by considering cleaner production from company utilities to production capacity, technology and outsourcing and ii infrastructure changes related to market attendance and environmental education dissemination. Needs that arise can be grouped as follows: utilities adequacy, cleaner technologies and ecochains implementation; instruction and dissemination of environmental education; and necessity of the adoption of new paradigms.

Planning and Articulation in Incremental Word Production: Syllable-Frequency Effects in English

Science.gov (United States)

Cholin, Joana; Dell, Gary S.; Levelt, Willem J. M.

2011-01-01

We investigated the role of syllables during speech planning in English by measuring syllable-frequency effects. So far, syllable-frequency effects in English have not been reported. English has poorly defined syllable boundaries, and thus the syllable might not function as a prominent unit in English speech production. Speakers produced either…

Productivity and Performance through Marketing Planning

Directory of Open Access Journals (Sweden)

Cristian Morozan

2008-11-01

Full Text Available In the marketing area, planning might be defined as an anticipation process of those changes that affect the market and as an elaboration process of the corresponding action means. It will result in a marketing plan, which might be tactical (short-term period, spread on a period of time that might vary from six months to one year, or a strategic (long-term, spread on a period of time of three to ten years. Planning means building action programs in which the objectives, the set financing method or the steps of achieving it should be clearly defined. Marketing planning also proves to be important for its liaison between what the company can offer and the consumers’ needs and expectations.

An analytical hierarchy process and fuzzy inference system tsukamoto for production planning: a review and conceptual research

Directory of Open Access Journals (Sweden)

Abdul Talib Bon

2015-03-01

Full Text Available Production planning is an area that is very important on the corporate strategy-level decision-making, especially in the manufacturing companies. The problems that often arise in the production planning are the factors that affect the decline of production and uncertainty that often complicate the decision-making in the production process. These factors are derived from the company’s internal and external factors. The purpose of this study is to introduce the Analytical Hierarchy Process as an effective method that can help to determine the priority of the production factors, so as to facilitate and accelerate decision-making. Other than the AHP methods, this paper will introduce the Tsukamoto Fuzzy Inference System as a method that can help to determine how much product to be manufactured by the company using the variables in the form of fuzzy numbers. These methods hopefully can assist in a better decision making process in the production process and manufacturing generally.

Integrating design and production planning with knowledge-based inspection planning system

International Nuclear Information System (INIS)

Abbasi, Ghaleb Y.; Ketan, Hussein S.; Adil, Mazen B.

2005-01-01

In this paper an intelligent environment to integrate design and inspection earlier to the design stage. A hybrid knowledge-based approach integrating computer-aided design (CAD) and computer-aided inspection planning (CAIP) was developed, thereafter called computer-aided design and inspection planning (CADIP). CADIP was adopted for automated dimensional inspection planning. Critical functional features were screened based on certain attributes for part features for inspection planning application. Testing the model resulted in minimizing the number of probing vectors associated with the most important features in the inspected prismatic part, significant reduction in inspection costs and release of human labor. In totality, this tends to increase customer satisfaction as a final goal of the developed system. (author)

Production planning and control for semiconductor wafer fabrication facilities modeling, analysis, and systems

CERN Document Server

Mönch, Lars; Mason, Scott J

2012-01-01

Over the last fifty-plus years, the increased complexity and speed of integrated circuits have radically changed our world. Today, semiconductor manufacturing is perhaps the most important segment of the global manufacturing sector. As the semiconductor industry has become more competitive, improving planning and control has become a key factor for business success. This book is devoted to production planning and control problems in semiconductor wafer fabrication facilities. It is the first book that takes a comprehensive look at the role of modeling, analysis, and related information systems

78 FR 26301 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Consumer Products and...

Science.gov (United States)

2013-05-06

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R05-OAR-2010-0394; EPA-R05-OAR-2012-0786; FRL-9786-1] Approval and Promulgation of Air Quality Implementation Plans; Illinois; Consumer Products and... consumer products categories into the State's SIP. Finally, EPA is proposing to approve language to clarify...

Multiobjective Joint Optimization of Production Scheduling and Maintenance Planning in the Flexible Job-Shop Problem

Directory of Open Access Journals (Sweden)

Jianfei Ye

2015-01-01

Full Text Available In order to solve the joint optimization of production scheduling and maintenance planning problem in the flexible job-shop, a multiobjective joint optimization model considering the maximum completion time and maintenance costs per unit time is established based on the concept of flexible job-shop and preventive maintenance. A weighted sum method is adopted to eliminate the index dimension. In addition, a double-coded genetic algorithm is designed according to the problem characteristics. The best result under the circumstances of joint decision-making is obtained through multiple simulation experiments, which proves the validity of the algorithm. We can prove the superiority of joint optimization model by comparing the result of joint decision-making project with the result of independent decision-making project under fixed preventive maintenance period. This study will enrich and expand the theoretical framework and analytical methods of this problem; it provides a scientific decision analysis method for enterprise to make production plan and maintenance plan.

Inspection logistics planning for multi-stage production systems with applications to semiconductor fabrication lines

Science.gov (United States)

Chen, Kyle Dakai

Since the market for semiconductor products has become more lucrative and competitive, research into improving yields for semiconductor fabrication lines has lately received a tremendous amount of attention. One of the most critical tasks in achieving such yield improvements is to plan the in-line inspection sampling efficiently so that any potential yield problems can be detected early and eliminated quickly. We formulate a multi-stage inspection planning model based on configurations in actual semiconductor fabrication lines, specifically taking into account both the capacity constraint and the congestion effects at the inspection station. We propose a new mixed First-Come-First-Serve (FCFS) and Last-Come-First-Serve (LCFS) discipline for serving the inspection samples to expedite the detection of potential yield problems. Employing this mixed FCFS and LCFS discipline, we derive approximate expressions for the queueing delays in yield problem detection time and develop near-optimal algorithms to obtain the inspection logistics planning policies. We also investigate the queueing performance with this mixed type of service discipline under different assumptions and configurations. In addition, we conduct numerical tests and generate managerial insights based on input data from actual semiconductor fabrication lines. To the best of our knowledge, this research is novel in developing, for the first time in the literature, near-optimal results for inspection logistics planning in multi-stage production systems with congestion effects explicitly considered.

Plans for first oil production revived in two Sudanese fields

International Nuclear Information System (INIS)

Anon.

1993-01-01

A Vancouver, British Columbia, independent and its Sudanese partner have filed a development plan with the government of Sudan to produce an initial 40,000 b/d from Heglig and Unity oil fields in Sudan. Arakis Energy Corp., and the private Sudanese company State Petroleum Corp. (SPC) want to begin the first commercial hydrocarbon production in the destitute, war torn country. They are picking up where Chevron Corp. left off after years of grappling with an ambitious, costly - and ultimately futile - effort to export crude-oil from Sudan. After finding almost 300 million bbl of oil in Sudan during the early 1980s, Chevron scuttled a $2 billion project to export 50,000 b/d of Sudanese crude in 1986. It drilled 90 wells and sank more than $1 billion into the project. But it dropped the plan, citing the 1986 collapse of oil prices and concerns over security after repeated guerrilla attacks delayed work. The paper details the project

Product assurance planning in an environment of increased need for accountability

Science.gov (United States)

Esparza, V.; Casey, C.

1991-10-01

Projects producing data are too often providing a product that is neither defensible nor usable. Instead of planning for data of known and required quality, managers are too often asking for (and getting) the wrong thing. The problem is a lack of correct planning strategy. A planning strategy to produce usable, defensible data requires communication from the customer to top-level management and from top-level management to the project leader, who must then communicate with the technical experts who will run the project. EPA requires that data quality objectives (DQOs) be derived for RI/FS projects. The DQO process is a top-down planning process that requires two-way communication; some organizations do not have structures suited for implementing DQOs as mandated by EPA. This paper discusses specific tools for imposing structure that will make the DQO process easier to follow for many organizations. The tools include a steering committee, a test design team, and Quality Function Deployment (QFD) matrices. The steering committee is a strong technical forum that can develop technical issues systematically and break down technical issues into manageable pieces that can be stated as test objectives. The test design team plans each test, systematically designs the test matrix, and guides the completion of test documentation that will be used to defend the data collected. QFD matrices are used as tools by both steering committee and test design team as a highly structured, systematic means of relating top-level (customer) requirements to data quality needs and measurement system design.

Ergot fungus Claviceps cynodontis found on Bermuda grass (Cynodon dactylon) in the Americas

Czech Academy of Sciences Publication Activity Database

Pažoutová, Sylvie; Odvody, G.; Frederickson, D.E.

2005-01-01

Roč. 27, - (2005), s. 1-6 ISSN 0706-0661 Institutional research plan: CEZ:AV0Z5020903 Keywords : claviceps cynodon tis * ergot * bermuda grass Subject RIV: EE - Microbiology, Virology Impact factor: 1.066, year: 2005

National contingency plan product schedule data base

International Nuclear Information System (INIS)

Putukian, J.; Hiltabrand, R.R.

1993-01-01

During oil spills there are always proposals by the technical community and industry to use chemical agents to help in oil spill cleanups. Federal Clean Water Act regulations require that any chemical agents that the federal on-scene coordinator (FOSC) wants to use for oil cleanup be listed on the US Environmental Protection Agency (EPA) National Contingency Plan (NCP) Product Schedule. Chemical countermeasures are among the most controversial, complex, and time-critical issues facing decision-making officials choosing response methods to use on coastal oil spills. There are situations in which dispersants are likely to be one of the most appropriate counter-measure strategies. Dispersants are most effective when applied to fresh oil, and their effectiveness dramatically decreases as the oil weathers, which can begin in as little as 24 hours. To logistically implement dispersant use, a decision would need to be made within roughly the first 4 hours after the release. Most of the information that the FOSC needs to make the determination to use a specific chemical agent exists in manuals, EPA bulletins, and the published literature. This information is not in an easy-to-use format under field emergency conditions. Hence the need to collect and disseminate the information in an automated data base. The sources for the information in this data base are the following. Published results of tests performed by Environment Canada; EPA bulletins associated with the NCP Product Schedule; Published results of tests by the chemical industry. The data base resides on a Macintosh computer and contains information about 70 NCP products, including dispersants, surface collecting agents, and biological additives. It contains information on physical properties, toxicity, heavy metal content, safety precautions, use conditions, etc

Harvest operations for density management: planning requirements, production, costs, stand damage, and recommendations

Science.gov (United States)

Loren D. Kellogg; Stephen J. Pilkerton

2013-01-01

Since the early 1990s, several studies have been undertaken to determine the planning requirements, productivity, costs, and residual stand damage of harvest operations in thinning treatments designed to promote development of complex forest structure in order to enhance ecological functioning and biological diversity. Th ese studies include the Oregon State...

Computer-aided process planning in prismatic shape die components based on Standard for the Exchange of Product model data

Directory of Open Access Journals (Sweden)

Awais Ahmad Khan

2015-11-01

Full Text Available Insufficient technologies made good integration between the die components in design, process planning, and manufacturing impossible in the past few years. Nowadays, the advanced technologies based on Standard for the Exchange of Product model data are making it possible. This article discusses the three main steps for achieving the complete process planning for prismatic parts of the die components. These three steps are data extraction, feature recognition, and process planning. The proposed computer-aided process planning system works as part of an integrated system to cover the process planning of any prismatic part die component. The system is built using Visual Basic with EWDraw system for visualizing the Standard for the Exchange of Product model data file. The system works successfully and can cover any type of sheet metal die components. The case study discussed in this article is taken from a large design of progressive die.

Production layout improvement by using line balancing and Systematic Layout Planning (SLP) at PT. XYZ

Science.gov (United States)

Buchari; Tarigan, U.; Ambarita, M. B.

2018-02-01

PT. XYZ is a wood processing company which produce semi-finished wood with production system is make to order. In the production process, it can be seen that the production line is not balanced. The imbalance of the production line is caused by the difference in cycle time between work stations. In addition, there are other issues, namely the existence of material flow pattern is irregular so it resulted in the backtracking and displacement distance away. This study aimed to obtain the allocation of work elements to specific work stations and propose an improvement of the production layout based on the result of improvements in the line balancing. The method used in the balancing is Ranked Positional Weight (RPW) or also known as Helgeson Birnie method. While the methods used in the improvement of the layout is the method of Systematic Layout Planning (SLP). By using Ranked Positional Weight (RPW) obtained increase in line efficiency becomes 84,86% and decreased balance delay becomes 15,14%. Repairing the layout using the method of Systematic Layout Planning (SLP) also give good results with a reduction in path length becomes 133,82 meters from 213,09 meters previously or a decrease of 37.2%.

Stochastic production planning for a biofuel supply chain under demand and price uncertainties

International Nuclear Information System (INIS)

Awudu, Iddrisu; Zhang, Jun

2013-01-01

Highlights: ► The proposed stochastic model outperforms the deterministic model. ► The price of biofuel is modeled as Geometric Brownian Motion (GBM). ► The proposed model can be applied in any biofuel supply chain. -- Abstract: In this paper, we propose a stochastic production planning model for a biofuel supply chain under demand and price uncertainties. The supply chain consists of biomass suppliers, biofuel refinery plants and distribution centers. A stochastic linear programming model is proposed within a single-period planning framework to maximize the expected profit. Decisions such as the amount of raw materials purchased, the amount of raw materials consumed and the amount of products produced are considered. Demands of end products are uncertain with known probability distributions. The prices of end products follow Geometric Brownian Motion (GBM). Benders decomposition (BD) with Monte Carlo simulation technique is applied to solve the proposed model. To demonstrate the effectiveness of the proposed stochastic model and the decomposition algorithm, a representative supply chain for an ethanol plant in North Dakota is considered. To investigate the results of the proposed model, a simulation framework is developed to compare the performances of deterministic model and proposed stochastic model. The results from the simulation indicate the proposed model obtain higher expected profit than the deterministic model under different uncertainty settings. Sensitivity analyses are performed to gain management insight on how profit changes due to the uncertainties affect the model developed.

Proposal for a strategic planning for the replacement of products in stores based on sales forecast

Directory of Open Access Journals (Sweden)

Cassius Tadeu Scarpin

2011-08-01

Full Text Available This paper presents a proposal for strategic planning for the replacement of products in stores of a supermarket network. A quantitative method for forecasting time series is used for this, the Artificial Radial Basis Neural Networks (RBFs, and also a qualitative method to interpret the forecasting results and establish limits for each product stock for each store in the network. The purpose with this strategic planning is to reduce the levels of out-of-stock products (lack of products on the shelves, as well as not to produce overstocking, in addition to increase the level of logistics service to customers. The results were highly satisfactory reducing the Distribution Center (DC to shop out-of-stock levels, in average, from 12% to about 0.7% in hypermarkets and from 15% to about 1.7% in supermarkets, thereby generating numerous competitive advantages for the company. The use of RBFs for forecasting proved to be efficient when used in conjunction with the replacement strategy proposed in this work, making effective the operational processes.

Revised Master Plan for the Hood River Production Program, Technical Report 2008.

Energy Technology Data Exchange (ETDEWEB)

Oregon Department of Fish and Wildlife; Confederated Tribes of the Warm Springs Reservation

2008-04-28

The Hood River Production Program (HRPP) is a Bonneville Power Administration (BPA) funded program initiated as a mitigation measure for Columbia River hydrosystem effects on anadromous fish. The HRPP began in the early 1990s with the release of spring Chinook and winter steelhead smolts into the basin. Prior to implementation, co-managers, including the Confederated Tribes of the Warm Springs Reservation and the Oregon Department of Fish and Wildlife drafted the Hood River Production Master Plan (O'Toole and ODFW 1991a; O'Toole and ODFW 1991b) and the Pelton Ladder Master Plan (Smith and CTWSR 1991). Both documents were completed in 1991 and subsequently approved by the Council in 1992 and authorized through a BPA-led Environmental Impact Statement in 1996. In 2003, a 10-year programmatic review was conducted for BPA-funded programs in the Hood River (Underwood et al. 2003). The primary objective of the HRPP Review (Review) was to determine if program goals were being met, and if modifications to program activities would be necessary in order to meet or revise program goals. In 2003, an agreement was signed between PacifiCorp and resource managers to remove the Powerdale Dam (RM 10) and associated adult trapping facility by 2010. The HRPP program has been dependant on the adult trap to collect broodstock for the hatchery programs; therefore, upon the dam's removal, some sort of replacement for the trap would be needed to continue the HRPP. At the same time the Hood River Subbasin Plan (Coccoli 2004) was being written and prompted the co-managers to considered future direction of the program. This included revising the numerical adult fish objectives based on the assimilated data and output from several models run on the Hood River system. In response to the Review as well as the Subbasin Plan, and intensive monitoring and evaluation of the current program, the HRPP co-managers determined the spring Chinook program was not achieving the HRPP

National Parks of New York Harbor Traveler Information System : Functional Requirements

Science.gov (United States)

2011-12-23

The purpose of this planning project is to analyze alternatives and design a Traveler Information System (TIS) that will enhance the experience of visitors to the NYNH parks and other sites managed by federal, state and local partners. The system wil...

Strategic planning as a competitive differential: A case study of the Sealed Sources Production Laboratory

International Nuclear Information System (INIS)

Vieira, Imário; Nascimento, Fernando C.; Calvo, Wilson A. Parejo

2017-01-01

Strategic planning has always been and continues to be one of the most important management tools for decision making. Amidst the uncertainties of the 21"s"t century, public, private and third sector organizations are steadily struggling to improve their strategic plans by using more effective results management tools such as BSC-Balanced Scorecard. Nuclear research institutes and research centers around the world have been using more and more these types of tools in their strategic planning and management. The objective of this article was to recommend the use the BSC as a strategic tool for decision making for the Sealed Sources Production Laboratory located in the Radiation Technology Center, at Nuclear and Energy Research Institute (IPEN/CNEN-SP), in Sao Paulo, Brazil. The methodology used in this academic article was a case study, which considered the object of the study, the Sealed Sources Production Laboratory, from January 2014 to August 2016. Among the main results obtained with this study can be cited: the improvement of the information flow, the visualization and proposition to change the periodicity of analysis of the results, among others. In view of the expected results, it was possible to conclude that this study may be of value to the Sealed Sources Production Laboratory for Industrial Radiography and Industrial Process Control and also to other research centers, as it will allow and contribute with an additional management support tool. (author)

Strategic planning as a competitive differential: A case study of the Sealed Sources Production Laboratory

Energy Technology Data Exchange (ETDEWEB)

Vieira, Imário; Nascimento, Fernando C.; Calvo, Wilson A. Parejo, E-mail: imariovieira@yahoo.com, E-mail: wapcalvo@ipen.br, E-mail: fcodelo@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Faculdade SENAI de Tecnologia Ambiental, Sao Bernardo do Campo, SP (Brazil)

2017-11-01

Strategic planning has always been and continues to be one of the most important management tools for decision making. Amidst the uncertainties of the 21{sup st} century, public, private and third sector organizations are steadily struggling to improve their strategic plans by using more effective results management tools such as BSC-Balanced Scorecard. Nuclear research institutes and research centers around the world have been using more and more these types of tools in their strategic planning and management. The objective of this article was to recommend the use the BSC as a strategic tool for decision making for the Sealed Sources Production Laboratory located in the Radiation Technology Center, at Nuclear and Energy Research Institute (IPEN/CNEN-SP), in Sao Paulo, Brazil. The methodology used in this academic article was a case study, which considered the object of the study, the Sealed Sources Production Laboratory, from January 2014 to August 2016. Among the main results obtained with this study can be cited: the improvement of the information flow, the visualization and proposition to change the periodicity of analysis of the results, among others. In view of the expected results, it was possible to conclude that this study may be of value to the Sealed Sources Production Laboratory for Industrial Radiography and Industrial Process Control and also to other research centers, as it will allow and contribute with an additional management support tool. (author)

Scenario Approach to the Planning of the Production Activities of the Enterprise with a Discrete Type of Production (for Example, Electrical Engineering Industry

Directory of Open Access Journals (Sweden)

Krylova E.V.

2017-12-01

Full Text Available In conditions of global economic instability the success of electromechanical enterprises depends on their ability to react quickly to challenges of external environment. In order to create background and conditions for this ability the given enterprises refer to manufacturing activity planning, using a probabilistic approach based on forecasts that may not be true. The question of provision of more complete consideration of various internal and external factors and acceleration of decision making process and reaction to changing business environment arises before the organizations that concern more effective scheduling policy. International practice of solving such problems generally leads to qualitative discussion, whereas quantitative assessment of impact of control parameters of enterprise is not practically used, because there is no one systematic approach to manufacturing activity planning. On the basis of studying of international practices methodical guidelines of scenario approach to manufacturing activity planning with mathematical modeling of economics of producer price on electromechanical enterprises have been developed, which reasonably could be used with reference to and interaction with enterprise manufacturing program. The described approach allows solving planning problems iteratively in real-time mode concerning profit maximization, to form producer prices, to divide overhead costs according to the type of products and carry out cost accounting according to the type of a product, and it will provide functional interaction between factors and performance indicators.

Planning woody biomass logistics for energy production: A strategic decision model

International Nuclear Information System (INIS)

Frombo, F.; Robba, M.; Minciardi, R.; Sacile, R.; Rosso, F.

2009-01-01

One of the key factors on which the sustainable development of modern society should be based is the possibility to take advantage of renewable energies. Biomass resources are one of the most common and widespread resources in the world. Their use to produce energy has many advantages, such as the reduction of greenhouse emissions. This paper describes a GIS-based Environmental Decision Support System (EDSS) to define planning and management strategies for the optimal logistics for energy production from woody biomass, such as forest biomass, agricultural scraps and industrial and urban untreated wood residues. The EDSS is characterized by three main levels: the GIS, the database, and the optimization. The optimization module is divided in three sub-modules to face different kinds of decision problems: strategic planning, tactical planning, and operational management. The aim of this article is to describe the strategic planning level in detail. The decision variables are represented by plant capacity and harvested biomass in a specific forest parcel for each slope class, while the objective function is the sum of the costs related to plant installation and maintenance, biomass transportation and collection, minus the benefits coming from the energy sales at the current market price, including the renewable energy certificates. Moreover, the optimization problem is structured through a set of parameters and equations that are able to encompass different energy conversion technologies (pyrolysis, gasification or combustion) in the system. A case study on the Liguria Region (Savona Province) is presented and results are discussed. (author)

The virtual maintenance system: a computer-based support tool for robust design, product monitoring, fault diagnosis and maintenance planning

NARCIS (Netherlands)

van Houten, Frederikus J.A.M.; Kimura, F.

2000-01-01

Digital (geometric) product models can be used for maintainability analysis and maintenance planning. It is not feasible to build digital product models for maintenance purposes only, but if a digital product model is available, it may be used to support many maintenance-related engineering tasks.

An effective heuristic for combined heat-and-power production planning with power ramp constraints

International Nuclear Information System (INIS)

Rong, Aiying; Lahdelma, Risto

2007-01-01

Combined heat-and-power (CHP) production is an increasingly important technology for its efficient utilization of primary-energy resources and for reducing CO 2 emissions. In the CHP plant, the generation of heat-and-power follows a joint characteristic, which makes the determination of both the marginal power production cost (MPPC) and the feasible operating region for the plant more complicated than for the power-only generation plant. Due to the interdependence between heat and power production, the power-ramp constraints, which limit how much the power production of a CHP plant may increase or decrease between two successive periods, may also imply constraints on the heat production. In this paper, we investigate the impact of power-ramp constraints on CHP production planning and develop a robust heuristic for dealing with the power-ramp constraints based on the solution to the problem with relaxed ramp-constraints (RRC). Numerical results based on realistic production models show that the heuristic can generate high-quality solutions efficiently. (author)

Microbiological sampling plan based on risk classification to verify supplier selection and production of served meals in food service operation.

Science.gov (United States)

Lahou, Evy; Jacxsens, Liesbeth; Van Landeghem, Filip; Uyttendaele, Mieke

2014-08-01

Food service operations are confronted with a diverse range of raw materials and served meals. The implementation of a microbial sampling plan in the framework of verification of suppliers and their own production process (functionality of their prerequisite and HACCP program), demands selection of food products and sampling frequencies. However, these are often selected without a well described scientifically underpinned sampling plan. Therefore, an approach on how to set-up a focused sampling plan, enabled by a microbial risk categorization of food products, for both incoming raw materials and meals served to the consumers is presented. The sampling plan was implemented as a case study during a one-year period in an institutional food service operation to test the feasibility of the chosen approach. This resulted in 123 samples of raw materials and 87 samples of meal servings (focused on high risk categorized food products) which were analyzed for spoilage bacteria, hygiene indicators and food borne pathogens. Although sampling plans are intrinsically limited in assessing the quality and safety of sampled foods, it was shown to be useful to reveal major non-compliances and opportunities to improve the food safety management system in place. Points of attention deduced in the case study were control of Listeria monocytogenes in raw meat spread and raw fish as well as overall microbial quality of served sandwiches and salads. Copyright © 2014 Elsevier Ltd. All rights reserved.

An efficient algorithm for bi-objective combined heat and power production planning under the emission trading scheme

International Nuclear Information System (INIS)

Rong, Aiying; Figueira, José Rui; Lahdelma, Risto

2014-01-01

Highlights: • Define fuel mix setting for the bi-objective CHP environmental/economic dispatch. • Develop an efficient algorithm for constructing the Pareto frontier for the problem. • Time complexity analysis is conducted for the proposed algorithm. • The algorithm is theoretically compared against a traditional algorithm. • The efficiency of the algorithm is justified by numerical results. - Abstract: The growing environmental awareness and the apparent conflicts between economic and environmental objectives turn energy planning problems naturally into multi-objective optimization problems. In the current study, mixed fuel combustion is considered as an option to achieve tradeoff between economic objective (associated with fuel cost) and emission objective (measured in CO 2 emission cost according to fuels and emission allowance price) because a fuel with higher emissions is usually cheaper than one with lower emissions. Combined heat and power (CHP) production is an important high-efficiency technology to promote under the emission trading scheme. In CHP production, the production planning of both commodities must be done in coordination. A long-term planning problem decomposes into thousands of hourly subproblems. In this paper, a bi-objective multi-period linear programming CHP planning model is presented first. Then, an efficient specialized merging algorithm for constructing the exact Pareto frontier (PF) of the problem is presented. The algorithm is theoretically and empirically compared against a modified dichotomic search algorithm. The efficiency and effectiveness of the algorithm is justified

Functional overview of the Production Planning Model (ProdMod)

International Nuclear Information System (INIS)

Gregory, M.V.; Paul, P.K.

1995-09-01

The Production Planning Model (ProdMod) has been developed by SRTC for use by High Level Waste Program Management and High Level Waste Engineering as a fast running, integrated, comprehensive model of the entire SRS high level waste (HLW) complex. ProdMod can simulate the response of the HLW complex from its current state to the end of tank clean-up or to any intermediate point. The present document describes the initial release of ProdMod at the end of FY95: a model version that contains all the significant elements from the High-level Waste System Plan Revision 5 and is capable of running the simulation all the way to the postulated completion of waste removal. For the scenario represented by this release, that simulates approximately 70 years of operation of the HLW complex (out to FY2065). This initial release of ProdMod will serve as the immediate starting point for the modeling of the High-Level Waste System Plan Revision 6. Thus ProdMod is expected to be in a state of continuous change and improvement.the initial goal has been to generate a simulation of the processes of interest, with the emphasis on mass and volume balances tracked throughout the HLW complex. That has been accomplished. Future development will add a set of cost equations to the process equations and extend the model for use as a linear programming (optimization) application. The goal of this later phase will be to free the ProdMod user to some extent from the need to set up detailed simulation scenarios: the model will automatically make operational choices which minimize or maximize a given objective function. Appendix A contains the source code

The US department of energy's research and development plans for the use of nuclear energy for hydrogen production

International Nuclear Information System (INIS)

Henderson, A.D.; Pickard, P.S.; Park, C.V.; Kotek, J.F.

2004-01-01

The potential of hydrogen as a transportation fuel and for stationary power applications has generated significant interest in the United States. President George W. Bush has set the transition to a 'hydrogen economy' as one of the Administration's highest priorities. A key element of an environmentally-conscious transition to hydrogen is the development of hydrogen production technologies that do not emit greenhouse gases or other air pollutants. The Administration is investing in the development of several technologies, including hydrogen production through the use of renewable fuels, fossil fuels with carbon sequestration, and nuclear energy. The US Department of Energy's Office of Nuclear Energy, Science and Technology initiated the Nuclear Hydrogen Initiative to develop hydrogen production cycles that use nuclear energy. The Nuclear Hydrogen Initiative has completed a Nuclear Hydrogen R and D Plan to identify candidate technologies, assess their viability, and define the R and D required to enable the demonstration of nuclear hydrogen production by 2016. This paper gives a brief overview of the Nuclear Hydrogen Initiative, describes the purposes of the Nuclear Hydrogen R and D Plan, explains the methodology followed to prepared the plan, presents the results, and discusses the path forward for the US programme to develop technologies which use nuclear energy to produce hydrogen. (author)

Plans for industrial production of the SSC magnets

International Nuclear Information System (INIS)

Karpenko, V.N.; Rardin, D.C.

1986-01-01

The Universities Research Association through its Central Design Group is currently conducting research and development for the Department of Energy on a superconducting super collider (SSC). The proposed SSC is a device in which protons would be accelerated around a ring approximately 50 miles in circumference. The protons would be kept in their path by means of thousands of powerful superconducting magnets. Two such rings of magnets would be housed in a common underground tunnel, allowing groups of protons to be accelerated in opposite directions and collided, in order to study the fundamental nature of matter and energy. The magnet system is a major element of the SSC in terms of technical requirements, quantity of components and cost. In order to meet technical and production requirements imposed by this system early participation of industry is necessary. The program plans were developed with the objective to involve industry in the early stages of research and development of superconducting magnets, leading to cost effective processes of potential mass production of high quality accelerator magnets by industry. While a decision has not been made by the Department of Energy on whether or not to request construction of the SSC project, if such a request is made and the project is authorized and funded, it would lead to industrial manufacture of a large quantity of superconducting magnets

Designing a two-rank acceptance sampling plan for quality inspection of geospatial data products

Science.gov (United States)

Tong, Xiaohua; Wang, Zhenhua; Xie, Huan; Liang, Dan; Jiang, Zuoqin; Li, Jinchao; Li, Jun

2011-10-01

To address the disadvantages of classical sampling plans designed for traditional industrial products, we originally propose a two-rank acceptance sampling plan (TRASP) for the inspection of geospatial data outputs based on the acceptance quality level (AQL). The first rank sampling plan is to inspect the lot consisting of map sheets, and the second is to inspect the lot consisting of features in an individual map sheet. The TRASP design is formulated as an optimization problem with respect to sample size and acceptance number, which covers two lot size cases. The first case is for a small lot size with nonconformities being modeled by a hypergeometric distribution function, and the second is for a larger lot size with nonconformities being modeled by a Poisson distribution function. The proposed TRASP is illustrated through two empirical case studies. Our analysis demonstrates that: (1) the proposed TRASP provides a general approach for quality inspection of geospatial data outputs consisting of non-uniform items and (2) the proposed acceptance sampling plan based on TRASP performs better than other classical sampling plans. It overcomes the drawbacks of percent sampling, i.e., "strictness for large lot size, toleration for small lot size," and those of a national standard used specifically for industrial outputs, i.e., "lots with different sizes corresponding to the same sampling plan."

Productivity Sharing Programs: Can They Contribute to Productivity Improvement?

Science.gov (United States)

General Accounting Office, Washington, DC.

Productivity sharing plans were studied to determine how they operate, what benefits result, and whether long-term increases in productivity can be realized through the program. Thirty-six firms were interviewed that had productivity sharing plans. Nine firms that had either rejected adoption of a productivity sharing plan or were still…

The text plan concept: contributions to the writing planning process

Directory of Open Access Journals (Sweden)

Ana Lúcia Tinoco Cabral

2013-12-01

Full Text Available Students - at different levels, ranging from early grades up to PhD - face problems both on comprehension and text production. This paper focuses on the text plan concept according to the DTA (Discourse Text Analysis approach, i.e., a principle of organization that allows students to put into practice the production intention as well as to arrange text information while producing; being responsible for the text compositional structure (Adam, 2008. The study analyzes the relation between text plan and the writing planning process, in which the first one provides the second with theoretical support. In order to develop such research, the study covers some issues related to the reading skill, analyzes an argumentative text as per its textual plan, and presents some reflections on the writing process, focusing on the relation between textual plan and the writing planning process.

Concepts and Plans towards fast large scale Monte Carlo production for the ATLAS Experiment

Science.gov (United States)

Ritsch, E.; Atlas Collaboration

2014-06-01

The huge success of the physics program of the ATLAS experiment at the Large Hadron Collider (LHC) during Run 1 relies upon a great number of simulated Monte Carlo events. This Monte Carlo production takes the biggest part of the computing resources being in use by ATLAS as of now. In this document we describe the plans to overcome the computing resource limitations for large scale Monte Carlo production in the ATLAS Experiment for Run 2, and beyond. A number of fast detector simulation, digitization and reconstruction techniques are being discussed, based upon a new flexible detector simulation framework. To optimally benefit from these developments, a redesigned ATLAS MC production chain is presented at the end of this document.

International practices in the provision of teratology information: a survey of international teratogen information programmes and comparisons with the North American model.

Science.gov (United States)

Hancock, Rebecca L; Ungar, Wendy J; Einarson, Adrienne; Koren, Gideon

2010-10-01

Teratology Information Services (TIS) provide health care professionals and the public with information regarding the safety and/or risk of exposures during pregnancy and lactation, mainly via telephone consultations. An international comparison of clinical practices at TIS has never been conducted. The survey objective was to compare international TIS to North American TIS, with an aim to identify strengths and challenges that can lead to service improvement. Twenty-two international TIS were approached for participation during an international conference. TIS were surveyed on information in six categories: services, staffing, operations, data collection, knowledge transfer activities and additional information. Data were summarized using descriptive statistics. Statistical tests were conducted using SPSS®. Sixteen TIS from 12 countries participated. Survey results were compared with previously reported results from a similar survey of North American TIS (16 US, two Canadian). TIS exist in a variety of departments and settings, but most commonly are in university hospitals. Pregnant women were the most commonly counselled group worldwide. International TIS spent significantly more time fielding inquiries regarding medications, while North American TIS had a wider variety of inquiry categories. All TIS could improve budget tracking. Overall, service practices and goals were similar, although international TIS conducted more follow-up with service users than North American TIS. This report offers TIS the first ever opportunity to compare practices. Increased dialogue between TIS encourages sharing of best practices and improves the ability of these important public health programmes to support women and health care providers. © 2010 Blackwell Publishing Ltd.

UTILIZING SYNTHETIC UV SPECTRA TO EXPLORE THE PHYSICAL BASIS FOR THE CLASSIFICATION OF LAMBDA BOÖTIS STARS

Energy Technology Data Exchange (ETDEWEB)

Cheng, Kwang-Ping; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind [Cal. State Univ., Fullerton, Fullerton, CA (United States); Neff, James E.; Steele, Patricia A. [College of Charleston, Charleston, SC (United States); Gray, Richard O. [Appalachian State Univ., Boone, NC (United States); Corbally, Christopher J. [Vatican Observatory, Tucson, AZ (United States)

2016-04-15

Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars.

UTILIZING SYNTHETIC UV SPECTRA TO EXPLORE THE PHYSICAL BASIS FOR THE CLASSIFICATION OF LAMBDA BOÖTIS STARS

International Nuclear Information System (INIS)

Cheng, Kwang-Ping; Johnson, Dustin M.; Tarbell, Erik S.; Romo, Christopher A.; Prabhaker, Arvind; Neff, James E.; Steele, Patricia A.; Gray, Richard O.; Corbally, Christopher J.

2016-01-01

Lambda Boo-type stars are a group of late B to early F-type Population I dwarfs that show mild to extreme deficiencies of iron-peak elements (up to 2 dex), but their C, N, O, and S abundances are near solar. This intriguing stellar class has recently regained the spotlight because of the directly imaged planets around a confirmed Lambda Boo star, HR 8799, and a suggested Lambda Boo star, Beta Pictoris. The discovery of a giant asteroid belt around Vega, another possible Lambda Boo star, also suggests hidden planets. The possible link between Lambda Boo stars and planet-bearing stars motivates us to study Lambda Boo stars systematically. Since the peculiar nature of the prototype Lambda Boötis was first noticed in 1943, Lambda Boo candidates published in the literature have been selected using widely different criteria. In order to determine the origin of Lambda Boo stars’ unique abundance pattern and to better discriminate between theories explaining the Lambda Boo phenomenon, a consistent working definition of Lambda Boo stars is needed. We have re-evaluated all published Lambda Boo candidates and their available ultraviolet and visible spectra. In this paper, using observed and synthetic spectra, we explore the physical basis for the classification of Lambda Boo stars, and develop quantitative criteria that discriminate metal-poor stars from bona fide Lambda Boo stars. Based on these stricter Lambda Boo classification criteria, we conclude that neither Beta Pictoris nor Vega should be classified as Lambda Boo stars

Changed planning for planned and unplanned change

NARCIS (Netherlands)

Woerkum, van C.; Aarts, N.; Herzele, Van A.

2011-01-01

Change, planned and unplanned, can be the product of events (change by chance), new language (change from societal interaction), and practices (track-bound change), and can involve many different societal actors. To position planning as an activity within this broader context, we present a model

A New View at the Planning Marketing Popular Products: Exploratory Study Electronics Sector with Companies in Brazil.

OpenAIRE

Evange Elias Assis; Francisco Antonio Serralvo; Karen Perrotta Lopes de Almeida Prado

2015-01-01

The increased consumption of appliance and electronic products by lower-income population represented a growth opportunity for companies in the sector. The overall objective of this paper is to investigate how appliance and electronic product manufacturers draw up their marketing planning for low-end products. An exploratory approach was taken in this study, comprising the literature review and the empirical research which was conducted in two stages by combining the qualitative and quantitat...

Production Planning with Load Dependent Lead Times

DEFF Research Database (Denmark)

Pahl, Julia

2005-01-01

Lead times impact the performance of the supply chain significantly. Although there is a large literature concerning queuing models for the analysis of the relationship between capacity utilization and lead times, and there is a substantial literature concerning control and order release policies...... that take lead times into consideration, there have been only few papers describing models at the aggregate planning level that recognize the relationship between the planned utilization of capacity and lead times. In this paper we provide an in-depth discussion of the state-of-the art in this literature......, with particular attention to those models that are appropriate at the aggregate planning level....

15 CFR 714.3 - Advance declaration requirements for additionally planned production of Schedule 3 chemicals.

Science.gov (United States)

2010-01-01

... COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 3 CHEMICALS § 714.3 Advance... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Advance declaration requirements for additionally planned production of Schedule 3 chemicals. 714.3 Section 714.3 Commerce and Foreign Trade...

The association of household food security, household characteristics and school environment with obesity status among off-reserve First Nations and Métis children and youth in Canada: results from the 2012 Aboriginal Peoples Survey.

Science.gov (United States)

Bhawra, Jasmin; Cooke, Martin J; Guo, Yanling; Wilk, Piotr

2017-03-01

Indigenous children are twice as likely to be classified as obese and three times as likely to experience household food insecurity when compared with non- Indigenous Canadian children. The purpose of this study was to explore the relationship between food insecurity and weight status among Métis and off-reserve First Nations children and youth across Canada. We obtained data on children and youth aged 6 to 17 years (n = 6900) from the 2012 Aboriginal Peoples Survey. We tested bivariate relationships using Pearson chi-square tests and used nested binary logistic regressions to examine the food insecurity-weight status relationship, after controlling for geography, household and school characteristics and cultural factors. Approximately 22% of Métis and First Nations children and youth were overweight, and 15% were classified as obese. Over 80% of the sample was reported as food secure, 9% experienced low food security and 7% were severely food insecure. Off-reserve Indigenous children and youth from households with very low food security were at higher risk of overweight or obese status; however, this excess risk was not independent of household socioeconomic status, and was reduced by controlling for household income, adjusted for household size. Negative school environment was also a significant predictor of obesity risk, independent of demographic, household and geographic factors. Both food insecurity and obesity were prevalent among the Indigenous groups studied, and our results suggest that a large proportion of children and youth who are food insecure are also overweight or obese. This study reinforces the importance of including social determinants of health, such as income, school environment and geography, in programs or policies targeting child obesity.

Inter-subject variability modulates phonological advance planning in the production of adjective-noun phrases.

Science.gov (United States)

Michel Lange, Violaine; Laganaro, Marina

2014-01-01

The literature on advance phonological planning in adjective-noun phrases (NPs) presents diverging results: while many experimental studies suggest that the entire NP is encoded before articulation, other results favor a span of encoding limited to the first word. Although cross-linguistic differences in the structure of adjective-NPs may account for some of these contrasting results, divergences have been reported even among similar languages and syntactic structures. Here we examined whether inter-individual differences account for variability in the span of phonological planning in the production of French NPs, where previous results indicated encoding limited to the first word. The span of phonological encoding is tested with the picture-word interference (PWI) paradigm using phonological distractors related to the noun or to the adjective of the NPs. In Experiment 1, phonological priming effects were limited to the first word in adjective NPs whichever the position of the adjective (pre-nominal or post-nominal). Crucially, phonological priming effects on the second word interacted with speakers' production speed suggesting different encoding strategies for participants. In Experiment 2, we tested this hypothesis further with a larger group of participants. Results clearly showed that slow and fast initializing participants presented different phonological priming patterns on the last element of adjective-NPs: while the first word was primed by a distractor for all speakers, only the slow speaker group presented a priming effect on the second element of the NP. These results show that the span of phonological encoding is modulated by inter-individual strategies: in experimental paradigms some speakers plan word by word whereas others encode beyond the initial word. We suggest that the diverging results reported in the literature on advance phonological planning may partly be reconciled in light of the present results.

Production and Maintenance Planning for a Deteriorating System with Operation-Dependent Defectives

Directory of Open Access Journals (Sweden)

Héctor Rivera-Gómez

2018-01-01

Full Text Available This paper provides new insights to the area of sustainable manufacturing systems at analyzing the novel paradigm of integrated production logistics, quality, and maintenance design. For this purpose, we investigate the optimal production and repair/major maintenance switching strategy of an unreliable deteriorating manufacturing system. The effects of the deterioration process are mainly observed on the failure intensity and on the quality of the parts produced, where the rate of defectives depends on the production rate. When unplanned failures occur, either a minimal repair or a major maintenance could be conducted. The integration of availability and quality deterioration led us to propose a new stochastic dynamic programming model where optimality conditions are derived through the Hamilton-Jacobi-Bellman equations. The model defined the joint production and repair/major maintenance switching strategies minimizing the total cost over an infinite planning horizon. In the results, the influence of the deterioration process were evident in both the production and maintenances control parameters. A numerical example and an extensive sensitivity analysis were conducted to illustrate the usefulness of the results. Finally, the proposed control policy was compared with alternative strategies based on common assumptions of the literature in order to illustrate its efficiency.

JOINT OPTIMIZATION OF PRODUCTION PLANNING AND VEHICLE ROUTING PROBLEMS: A REVIEW OF EXISTING STRATEGIES

Directory of Open Access Journals (Sweden)

Marc Reimann

2014-05-01

Full Text Available Keen competition and increasingly demanding customers have forced companies to use their resources more efficiently and to integrate production and transportation planning. In the last few years more and more researchers have also focused on this challenging problem by trying to determine the complexity of the individual problems and then developing fast and robust algorithms to solve them. This paper reviews existing literature on integrated production and distribution decisions at the tactical and operational level, where the distribution part is modelled as some variation of the well-known Vehicle Routing Problem (VRP. The focus is thereby on problems that explicitly consider deliveries to multiple clients in a less-than-truckload fashion. In terms of the production decisions we distinguish in our review between tactical and operational production problems by considering lot-sizing/capacity allocation and scheduling models, respectively.

Joint optimization of preventive maintenance and spare parts inventory for an optimal production plan with consideration of CO_2 emission

International Nuclear Information System (INIS)

Ba, Kader; Dellagi, Sofiene; Rezg, Nidhal; Erray, Walid

2016-01-01

This article presents a joint optimization of spare parts inventory and preventive maintenance. While minimizing CO_2 emissions, this approach is based on an optimal production plan achieved thanks to the HMMS model. The process which is studied in this paper only manufactures one type of product. The purpose of the paper is to determine for a random demand over a given period, a cost-effective production plan and a maintenance policy which integrates a spare parts strategy in accordance with environmental requirements and regulations. Our green spare parts management can be defined as a set of actions that are applied in order to decrease the spare parts footprint in its lifetime (Ba et al., 2015) [1]. Indeed, we take into account the spare parts characteristics (new or used) which will be used during maintenance actions (preventive or corrective) to preserve the environment. Consequently, we set up analytical models based on the effect of the production rate on the system deterioration so as to substantially cut the maintenance costs, production costs and CO_2 emissions. To evaluate the performance of our models, we give some illustrative examples. - Highlights: • Establishment of an optimal production plan for a manufacturing process. • Cost-effective maintenance strategy with a green spare parts strategy. • Possibility to choose between used and new spare parts to execute maintenance action.

Radioactive waste management plan. Plan 82

International Nuclear Information System (INIS)

1982-06-01

The report is the first account of the nuclear power utilities of Sweden about the plans for the final disposal of the radioactive waste products of the nuclear power. Part 1 describes the general background, the plans for research and development, including the necessary facilities. The time schedule and the calculated costs of the operations are presented. (G.B.)

In vitro propagation of ‘FHIA-25’ (Musa spp., AAB in Temporary Immersion Systems

Directory of Open Access Journals (Sweden)

Milagros Basail Pérez

2011-01-01

Full Text Available Necessity to produce high quality planting material has required searching new alternatives to increase the efficiency of in vitro propagation methods and their automation, as in Temporary Immersion Systems (TIS. This work was aimed to multiply the hybrid ‘FHIA-25’ (Musa spp. AAB in TIS. The effect of different culture medium volumes per explant and densities of planting materials per culture flask at the same immersion frequency was determined. These two factors showed influence on the evaluated variables. A volume of 40 ml of culture medium per explant and densities of 80 explants per flask were selected to multiply this cultivar in TIS. These results permitted to increase in vitro production of high-quality plants for rooting stage. Key words: multiplication coefficient, culture flasks, liquid culture medium

Concepts and Plans towards fast large scale Monte Carlo production for the ATLAS Experiment

CERN Document Server

Chapman, J; Duehrssen, M; Elsing, M; Froidevaux, D; Harrington, R; Jansky, R; Langenberg, R; Mandrysch, R; Marshall, Z; Ritsch, E; Salzburger, A

2014-01-01

The huge success of the physics program of the ATLAS experiment at the Large Hadron Collider (LHC) during run I relies upon a great number of simulated Monte Carlo events. This Monte Carlo production takes the biggest part of the computing resources being in use by ATLAS as of now. In this document we describe the plans to overcome the computing resource limitations for large scale Monte Carlo production in the ATLAS Experiment for run II, and beyond. A number of fast detector simulation, digitization and reconstruction techniques and are being discussed, based upon a new flexible detector simulation framework. To optimally benefit from these developments, a redesigned ATLAS MC production chain is presented at the end of this document.

A simulation framework for the evaluation of production planning and order management strategies in the sawmilling industry

OpenAIRE

Dumetz , Ludwig; Gaudreault , Jonathan; Thomas , André; Marier , Philippe; Lehoux , Nadia; Bril El-Haouzi , Hind

2015-01-01

International audience; Raw material heterogeneity, complex transformation processes, and divergent product flowsmake sawmilling operationsdifficult to manage. Most north-American lumber sawmillsapply a make-to-stock production strategy, some accepting/refusing orders according to available-to-promise (ATP) quantities, while a few uses more advanced approaches. This article introduces a simulation framework allowing comparing and evaluatingdifferentproduction planning strategies as well as or...

Measuring and managing radiologist workload: application of lean and constraint theories and production planning principles to planning radiology services in mahjor tertiary hospital

International Nuclear Information System (INIS)

MacDonald, Sharyn L.S.; Cowan, Ian A.; Floyd, Richard; Mackintosh, Stuart; Graham, Rob; Jenkins, Emma; Hamilton, Richard

2013-01-01

We describe how techniques traditionally used in the manufacturing industry (lean management, the theory of constraints and production planning) can be applied to planning radiology services to reduce the impact of constraints such as limited radiologist hours, and to subsequently reduce delays in accessing imaging and in report turnaround. Targets for imaging and reporting were set aligned with clinical needs. Capacity was quantified for each modality and for radiologists and recorded in activity lists. Demand was quantified and forecasting commenced based on historical referral rates. To try and mitigate the impact of radiologists as a constraint, lean management processes were applied to radiologist workflows. A production planning process was implemented. Outpatient waiting times to access imaging steadily decreased. Report turnaround times improved with the percentage of overnight/on-call reports completed by a 1030 target time increased from approximately 30% to 80 to 90%. The percentage of emergency and inpatient reports completed within one hour increased from approximately 15% to approximately 50% with 80 to 90% available within 4 hours. The number of unreported cases on the radiologist work-list at the end of the working day reduced. The average weekly accuracy for demand forecasts for emergency and inpatient CT, MRI and plain film imaging was 91%, 83% and 92% respectively. For outpatient CT, MRI and plain film imaging the accuracy was 60%, 55% and 77% respectively. Reliable routine weekly and medium to longer term service planning is now possible. Tools from industry can be successfully applied to diagnostic imaging services to improve performance. They allow an accurate understanding of the demands on a service, capacity, and can reliably predict the impact of changes in demand or capacity on service delivery.

Utah ITS/CVO business plan : using technology to maximize highway safety and improve government and industry productivity

Science.gov (United States)

1997-12-31

This plan was produced to maximize highway safety and increase government and industry productivity through the application of Intelligent Transportation System/Commercial Vehicle Operations (ITS/CVO) technologies to support regulatory and enforcemen...

A Study on Promotion and Implementation of Cleaner Production Practices in Malaysian Industry - Development of a National Program and Action Plan for Promotion of Cleaner Production. Progress Report 1

DEFF Research Database (Denmark)

Wangel, Arne

This Progress Report presents the initial findings of the research project 'A Study on Promotion and Implementation of Cleaner Production Practices in Malaysian Industry - Development of a National Program and Action Plan for Promotion of Cleaner Production. Progress Report' funded...

Nuclear Criticality Information System. Database examples

Energy Technology Data Exchange (ETDEWEB)

Foret, C.A.

1984-06-01

The purpose of this publication is to provide our users with a guide to using the Nuclear Criticality Information System (NCIS). It is comprised of an introduction, an information and resources section, a how-to-use section, and several useful appendices. The main objective of this report is to present a clear picture of the NCIS project and its available resources as well as assisting our users in accessing the database and using the TIS computer to process data. The introduction gives a brief description of the NCIS project, the Technology Information System (TIS), online user information, future plans and lists individuals to contact for additional information about the NCIS project. The information and resources section outlines the NCIS database and describes the resources that are available. The how-to-use section illustrates access to the NCIS database as well as searching datafiles for general or specific data. It also shows how to access and read the NCIS news section as well as connecting to other information centers through the TIS computer.

Nuclear Criticality Information System. Database examples

International Nuclear Information System (INIS)

Foret, C.A.

1984-06-01

The purpose of this publication is to provide our users with a guide to using the Nuclear Criticality Information System (NCIS). It is comprised of an introduction, an information and resources section, a how-to-use section, and several useful appendices. The main objective of this report is to present a clear picture of the NCIS project and its available resources as well as assisting our users in accessing the database and using the TIS computer to process data. The introduction gives a brief description of the NCIS project, the Technology Information System (TIS), online user information, future plans and lists individuals to contact for additional information about the NCIS project. The information and resources section outlines the NCIS database and describes the resources that are available. The how-to-use section illustrates access to the NCIS database as well as searching datafiles for general or specific data. It also shows how to access and read the NCIS news section as well as connecting to other information centers through the TIS computer

Efficacité de l’outil CANRISK pour détecter la dysglycémie chez les membres des Premières Nations et les Métis au Canada

Directory of Open Access Journals (Sweden)

Gina Agarwal

2018-01-01

Full Text Available Introduction : Le diabète touche en plus grande proportion et à un plus jeune âge la population des Premières Nations et des Métis que le reste de la population canadienne. Cet article vise principalement à évaluer l’efficacité et les scores de risque de CANRISK (Questionnaire canadien sur le risque de diabète, un outil de dépistage du diabète destiné aux Canadiens de 40 ans et plus pour détecter la dysglycémie chez les participants issus des Premières Nations et d’origine métisse en incluant les moins de 40 ans. L’objectif secondaire de cette étude est de déterminer si une modification des seuils relatifs au tour de taille (TT et à l’indice de masse corporelle (IMC améliore la valeur prédictive de modèles de régression logistique lorsque les variables du questionnaire CANRISK sont utilisées pour prédire la dysglycémie. Méthodologie : Nous avons recueilli auprès de 1479 participants métis et des Premières Nations des données provenant d’un questionnaire CANRISK autoadministré, de mesures anthropométriques et de résultats d’épreuve standard d’hyperglycémie provoquée par voie orale (HGPO. Nous avons calculé la sensibilité et la spécificité des scores CANRISK en appliquant les seuils usuels de classification des risques. Une régression logistique a été effectuée en utilisant des seuils tenant compte de l’origine ethnique pour l’IMC et le TT pour prédire la dysglycémie à l’aide des variables CANRISK. Résultats : Appliqué aux résultats de l’épreuve d’HGPO, le score seuil CANRISK à 33 points a conduit à une sensibilité et une spécificité de l’outil CANRISK de respectivement 68 % et 63 % chez les 40 ans et plus, et de respectivement 27 % et 87 % chez les moins de 40 ans. L’utilisation d’un seuil inférieur, à 21 points, a fait monter à 77 % la sensibilité chez les moins de 40 ans, avec une spécificité de 44 %. Malgré la faible spécificité correspondant à ce

Implementing guidelines and training initiatives to improve cross-cultural communication in primary care consultations: a qualitative participatory European study.

Science.gov (United States)

Teunissen, E; Gravenhorst, K; Dowrick, C; Van Weel-Baumgarten, E; Van den Driessen Mareeuw, F; de Brún, T; Burns, N; Lionis, C; Mair, F S; O'Donnell, C; O'Reilly-de Brún, M; Papadakaki, M; Saridaki, A; Spiegel, W; Van Weel, C; Van den Muijsenbergh, M; MacFarlane, A

2017-02-10

Cross-cultural communication in primary care is often difficult, leading to unsatisfactory, substandard care. Supportive evidence-based guidelines and training initiatives (G/TIs) exist to enhance cross cultural communication but their use in practice is sporadic. The objective of this paper is to elucidate how migrants and other stakeholders can adapt, introduce and evaluate such G/TIs in daily clinical practice. We undertook linked qualitative case studies to implement G/TIs focused on enhancing cross cultural communication in primary care, in five European countries. We combined Normalisation Process Theory (NPT) as an analytical framework, with Participatory Learning and Action (PLA) as the research method to engage migrants, primary healthcare providers and other stakeholders. Across all five sites, 66 stakeholders participated in 62 PLA-style focus groups over a 19 month period, and took part in activities to adapt, introduce, and evaluate the G/TIs. Data, including transcripts of group meetings and researchers' fieldwork reports, were coded and thematically analysed by each team using NPT. In all settings, engaging migrants and other stakeholders was challenging but feasible. Stakeholders made significant adaptations to the G/TIs to fit their local context, for example, changing the focus of a G/TI from palliative care to mental health; or altering the target audience from General Practitioners (GPs) to the wider multidisciplinary team. They also progressed plans to deliver them in routine practice, for example liaising with GP practices regarding timing and location of training sessions and to evaluate their impact. All stakeholders reported benefits of the implemented G/TIs in daily practice. Training primary care teams (clinicians and administrators) resulted in a more tolerant attitude and more effective communication, with better focus on migrants' needs. Implementation of interpreter services was difficult mainly because of financial and other

Clean-up of liquid radiation wastes with elevated mineralization from cesium and cobalt radionuclides by the modified clinoptilolite of the Chankanaj deposit

International Nuclear Information System (INIS)

Plotnikov, V.I.; Tuleushev, A.Zh.; Zhabykbaev, G.T.; Kostsov, S.V.; Medvedeva, Z.V.; Plotnikova, O.M.; Chakrova, E.T.; Idrisova, U.R.; Idrisova, D.Zh.

2003-01-01

On the base of laboratory studies and semi-industrial testing the possibility of liquid radioactive wastes clean-up from cesium and cobalt radionuclides in elevated mineralization conditions with help of modified clinoptilolite is shown. In the work the synthesized thin-layer inorganic sorbent (TIS) with conventional name MC-2 (modified clinoptilolite) was used. The Chankanaj deposit's zeolite in the crushed form was base for the TIS production. The copper ferrocyanides serves as the modifier. This sorbent is selective one in relationship to cesium and cobalt radionuclides

Primary phonological planning units in spoken word production are language-specific: Evidence from an ERP study.

Science.gov (United States)

Wang, Jie; Wong, Andus Wing-Kuen; Wang, Suiping; Chen, Hsuan-Chih

2017-07-19

It is widely acknowledged in Germanic languages that segments are the primary planning units at the phonological encoding stage of spoken word production. Mixed results, however, have been found in Chinese, and it is still unclear what roles syllables and segments play in planning Chinese spoken word production. In the current study, participants were asked to first prepare and later produce disyllabic Mandarin words upon picture prompts and a response cue while electroencephalogram (EEG) signals were recorded. Each two consecutive pictures implicitly formed a pair of prime and target, whose names shared the same word-initial atonal syllable or the same word-initial segments, or were unrelated in the control conditions. Only syllable repetition induced significant effects on event-related brain potentials (ERPs) after target onset: a widely distributed positivity in the 200- to 400-ms interval and an anterior positivity in the 400- to 600-ms interval. We interpret these to reflect syllable-size representations at the phonological encoding and phonetic encoding stages. Our results provide the first electrophysiological evidence for the distinct role of syllables in producing Mandarin spoken words, supporting a language specificity hypothesis about the primary phonological units in spoken word production.

Two levels decision system for efficient planning and implementation of bioenergy production

International Nuclear Information System (INIS)

Ayoub, Nasser; Martins, Ricardo; Wang, Kefeng; Seki, Hiroya; Naka, Yuji

2007-01-01

When planning bioenergy production from biomass, planners should take into account each and every stakeholder along the biomass supply chains, e.g. biomass resources suppliers, transportation, conversion and electricity suppliers. Also, the planners have to consider social concerns, environmental and economical impacts related with establishing the biomass systems and the specific difficulties of each country. To overcome these problems in a sustainable manner, a robust decision support system is required. For that purpose, a two levels general Bioenergy Decision System (gBEDS) for bioenergy production planning and implementation was developed. The core part of the gBEDS is the information base, which includes the basic bioenergy information and the detailed decision information. Basic bioenergy information include, for instance, the geographical information system (GIS) database, the biomass materials' database, the biomass logistic database and the biomass conversion database. The detailed decision information considers the parameters' values database with their default values and the variables database, values obtained by simulation and optimization. It also includes a scenario database, which is used for demonstration to new users and also for case based reasoning by planners and executers. Based on the information base, the following modules are included to support decision making: the simulation module with graph interface based on the unit process (UP) definition and the genetic algorithms (GAs) methods for optimal decisions and the Matlab module for applying data mining methods (fuzzy C-means clustering and decision trees) to the biomass collection points, to define the location of storage and bioenergy conversion plants based on the simulation and optimization model developed of the whole life cycle of bioenergy generation. Furthermore, Matlab is used to set up a calculation model with crucial biomass planning parameters (e.g. costs, CO 2 emissions), over

Autocidal fight against the Mediterranean fruit fly: Ceratitis capitata Wiedemann (Diptera, Tephritidae)

International Nuclear Information System (INIS)

Titouhi, Faten; Maalaoui, Sana

2010-01-01

Our study which aims at the control of the TIS consisted in following the stages of breeding of the fly and carrying out lachers sterile insects. We noticed during the massive breeding, a monitoring of the physicochemical parameters (pH, Porosite) and climatic conditions of the mediums and the rooms of breeding (temperature, Humidity) allows a significant productivity in quantity. However, a good productivity inevitably does not imply a good quality, this was illustrated by the tests of quality control of the most productive transfers (weight and number of pupes/2ml, aptitude for thr flight, recombination). The very start of the lachers what increases the effectiveness of the technique of the sterile insect (TIS). A good control of the breeding makes it possible to have a massive production to be able to make homogenous lachers.

A Column-Generation Approach for a Short-Term Production Planning Problem in Closed-Loop Supply Chains

Directory of Open Access Journals (Sweden)

Florian Sahling

2013-05-01

Full Text Available We present a new model formulation for a multi-product lot-sizing problem with product returns and remanufacturing subject to a capacity constraint. The given external demand of the products has to be satisfied by remanufactured or newly produced goods. The objective is to determine a feasible production plan, which minimizes production, holding, and setup costs. As the LP relaxation of a model formulation based on the well-known CLSP leads to very poor lower bounds, we propose a column-generation approach to determine tighter bounds. The lower bound obtained by column generation can be easily transferred into a feasible solution by a truncated branch-and-bound approach using CPLEX. The results of an extensive numerical study show the high solution quality of the proposed solution approach.

Measuring and managing radiologist workload: application of lean and constraint theories and production planning principles to planning radiology services in a major tertiary hospital.

Science.gov (United States)

MacDonald, Sharyn L S; Cowan, Ian A; Floyd, Richard; Mackintosh, Stuart; Graham, Rob; Jenkins, Emma; Hamilton, Richard

2013-10-01

We describe how techniques traditionally used in the manufacturing industry (lean management, the theory of constraints and production planning) can be applied to planning radiology services to reduce the impact of constraints such as limited radiologist hours, and to subsequently reduce delays in accessing imaging and in report turnaround. Targets for imaging and reporting were set aligned with clinical needs. Capacity was quantified for each modality and for radiologists and recorded in activity lists. Demand was quantified and forecasting commenced based on historical referral rates. To try and mitigate the impact of radiologists as a constraint, lean management processes were applied to radiologist workflows. A production planning process was implemented. Outpatient waiting times to access imaging steadily decreased. Report turnaround times improved with the percentage of overnight/on-call reports completed by a 1030 target time increased from approximately 30% to 80 to 90%. The percentage of emergency and inpatient reports completed within one hour increased from approximately 15% to approximately 50% with 80 to 90% available within 4 hours. The number of unreported cases on the radiologist work-list at the end of the working day reduced. The average weekly accuracy for demand forecasts for emergency and inpatient CT, MRI and plain film imaging was 91%, 83% and 92% respectively. For outpatient CT, MRI and plain film imaging the accuracy was 60%, 55% and 77% respectively. Reliable routine weekly and medium to longer term service planning is now possible. Tools from industry can be successfully applied to diagnostic imaging services to improve performance. They allow an accurate understanding of the demands on a service, capacity, and can reliably predict the impact of changes in demand or capacity on service delivery. © 2013 The Royal Australian and New Zealand College of Radiologists.

Application of the Extended Theory of Planned Behavior Model to Investigate Purchase Intention of Green Products among Thai Consumers

OpenAIRE

Kamonthip Maichum; Surakiat Parichatnon; Ke-Chung Peng

2016-01-01

Green products are among the widely used products worldwide due to their environmental benefits. However, information on the consumers’ purchase intention towards green products in developing countries, such as Thailand, is lacking. This study aims to investigate Thai consumers who are aged over 18 years, and whose base education is high school, on purchase intention for green products by using an extended framework of the theory of planned behavior (TPB). We derived and examined the model th...

Providing information regarding exposures in pregnancy: a survey of North American Teratology Information Services.

Science.gov (United States)

Hancock, Rebecca L; Ungar, Wendy J; Einarson, Adrienne; Goodstadt, Michael; Koren, Gideon

2008-04-01

Teratology Information Services (TIS) provide information on exposures during pregnancy and breast-feeding. Maintaining ongoing funding is a challenge. The purpose was to gather descriptive information on current TIS operations. All North American TIS (16 American, 2 Canadian) completed a detailed survey. Service goal ranked as most important was correction of risk misperceptions. Inquiries were primarily for medications (mean 43.5%, S.D. 14.1), lactation exposures, and workplace exposures. Median employees per TIS: three (range 1-12.5). Two TIS only counsel health care professionals (HCPs). Main callers to remaining TIS were pregnant women (mean 46.8%, S.D. 22.8), physicians, and nurses. Calls per week varied (median 20, range 4-600). Median annual budget: US dollars 69,000 (range dollars 3000-335,000). Seventeen TIS collect patient data for research. This survey was the first to document TIS operations in North America and demonstrates a spectrum of clinical and research activities, and provides data for a future cost-benefit analysis of TIS.

Effects of triazole derivatives on strigolactone levels and growth retardation in rice.

Directory of Open Access Journals (Sweden)

Shinsaku Ito

Full Text Available We previously discovered a lead compound for strigolactone (SL biosynthesis inhibitors, TIS13 (2,2-dimethyl-7-phenoxy-4-(1H-1,2,4-triazol-1-ylheptan-3-ol. Here, we carried out a structure-activity relationship study of TIS13 to discover more potent and specific SL biosynthesis inhibitor because TIS13 has a severe side effect at high concentrations, including retardation of the growth of rice seedlings. TIS108, a new TIS13 derivative, was found to be a more specific SL biosynthesis inhibitor than TIS13. Treatment of rice seedlings with TIS108 reduced SL levels in both roots and root exudates in a concentration-dependent manner and did not reduce plant height. In addition, root exudates of TIS108-treated rice seedlings stimulated Striga germination less than those of control plants. These results suggest that TIS108 has a potential to be applied in the control of root parasitic weeds germination.

Grammatical Planning Units during Real-Time Sentence Production in Speakers with Agrammatic Aphasia and Healthy Speakers

Science.gov (United States)

Lee, Jiyeon; Yoshida, Masaya; Thompson, Cynthia K.

2015-01-01

Purpose: Grammatical encoding (GE) is impaired in agrammatic aphasia; however, the nature of such deficits remains unclear. We examined grammatical planning units during real-time sentence production in speakers with agrammatic aphasia and control speakers, testing two competing models of GE. We queried whether speakers with agrammatic aphasia…

Communication Planning.

Science.gov (United States)

Development Communication Report, 1978

1978-01-01

Communication planning in developing countries is discussed in individual articles on theory, knowledge production and utilization, planning at the regional level, software, and rural development. A nutrition education project and three experiments in developing educational materials with feedback from villagers in Africa are described in the…

Supply chain planning classification

Science.gov (United States)

Hvolby, Hans-Henrik; Trienekens, Jacques; Bonde, Hans

2001-10-01

Industry experience a need to shift in focus from internal production planning towards planning in the supply network. In this respect customer oriented thinking becomes almost a common good amongst companies in the supply network. An increase in the use of information technology is needed to enable companies to better tune their production planning with customers and suppliers. Information technology opportunities and supply chain planning systems facilitate companies to monitor and control their supplier network. In spite if these developments, most links in today's supply chains make individual plans, because the real demand information is not available throughout the chain. The current systems and processes of the supply chains are not designed to meet the requirements now placed upon them. For long term relationships with suppliers and customers, an integrated decision-making process is needed in order to obtain a satisfactory result for all parties. Especially when customized production and short lead-time is in focus. An effective value chain makes inventory available and visible among the value chain members, minimizes response time and optimizes total inventory value held throughout the chain. In this paper a supply chain planning classification grid is presented based current manufacturing classifications and supply chain planning initiatives.

Production planning of combined heat and power plants with regards to electricity price spikes : A machine learning approach

OpenAIRE

Fransson, Nathalie

2017-01-01

District heating systems could help manage the expected increase of volatility on the Nordic electricity market by starting a combined heat and power production plant (CHP) instead of a heat only production plant when electricity prices are expected to be high. Fortum Värme is interested in adjusting the production planning of their district heating system more towards high electricity prices and in their system there is a peak load CHP unit that could be utilised for this purpose. The econom...

Status and Planning of South Africa's Nuclear Hydrogen Production Program

Energy Technology Data Exchange (ETDEWEB)

Ravenswaay, J. P.; Niekerk, F.; Kriek, R. J.; Blom, E.; Krieg, H. M.; Niekerk, W. M. K.; Merwe, F.; Vosloo, H. C. M. [North-West University, Potchefstroom (South Africa)

2009-05-15

In May 2007 the South African Cabinet approved a National Hydrogen and Fuel Cell Technologies R and D and Innovation Strategy. The Strategy will focus on research, development and innovation for (amongst others) by building on the existing knowledge in High Temperature Gas Cooled Reactors (HTGR) and coal gasification Fischer-Tropsch technology, to develop local cost-competitive hydrogen production methods. As part of the roll-out strategy, the South African Department of Science and Technology (DST) created three Competence Centers (CC), including a Hydrogen Infrastructure Competence Centre hosted by the North-West University (NWU) and the Council for Scientific and Industrial Research (CSIR). The Hydrogen Infrastructure CC is tasked with developing Hydrogen Production, Storage, Distribution as well as Codes and Standards programs within the framework of the DST strategic objectives. A 700kW Heliostat field is to be constructed at the CSIR. It is planned that the following processes will be investigated there: Steam Methane Reforming, High Temperature Steam Electrolysis, Metal-oxide redox process. At the NWU the main focus will be on the large scale, CO{sub 2} free, hydrogen production through thermo-chemical water splitting using nuclear heat from a suitable heat source such as a HTGR. The following will be investigated: Plasma-arc reforming of methane, Investigating the integration of a HTGR with a coal-to-liquid process, steel manufacture and ammonia production, The Hybrid-Sulphur process for the production of hydrogen.

A model for optimizing the production of pharmaceutical products

Directory of Open Access Journals (Sweden)

Nevena Gospodinova

2017-05-01

Full Text Available The problem associated with the optimal production planning is especially relevant in modern industrial enterprises. The most commonly used optimality criteria in this context are: maximizing the total profit; minimizing the cost per unit of production; maximizing the capacity utilization; minimizing the total production costs. This article aims to explore the possibility for optimizing the production of pharmaceutical products through the construction of a mathematical model that can be viewed in two ways – as a single-product model and a multi-product model. As an optimality criterion it is set the minimization of the cost per unit of production for a given planning period. The author proposes an analytical method for solving the nonlinear optimization problem. An optimal production plan of Tylosin tartrate is found using the single-product model.

MULTIPLE CRITERIA DECISION MAKING IN STRATEGIC PLANNING OF TABLE EGG PRODUCTION

Directory of Open Access Journals (Sweden)

Ana Crnčan

2016-06-01

Full Text Available The main research objective was to analyze and evaluate different systems of table egg production by using the multiple criteria analysis, the method of Analytic Hierarchy Process (AHP in decision making within strategic planning of production. The survey involved 79 producers of table eggs registered in the Records on laying hens’ farms in the Republic of Croatia. In the first stage, the research defined the criteria and sub-criteria for system evaluation which were compared in pairs in order to determine the weight or importance for each of them. Alternatives were evaluation based on definition of priorities of examinees and the extent to which they meet each of the defined criteria and sub-criteria. Intensity of examinees’ preferences were entered into the Expert Choice software in order to evaluate ranking results of egg production systems. Defined model consisted of a quantitative criterion of economic indicators, and the other two referred to qualitative criteria, market indicators and technical-technological factors. Each criterion had its corresponding sub-criteria that were evenly distributed in numerical order. Based on individual assessments of the examinees, overall cumulative evaluation was obtained for the table egg production systems. Accordingly, the most acceptable alternative to egg production is the indoor keeping system (priority 0.301. It is followed by the free-range system of keeping laying hens (priority 0.253. The third-ranked alternative is egg production by hens kept in conventional cages (priority 0.226, while the fourth-ranked least acceptable alternative, as of the total evaluation, is the ecological system of egg production (priority 0.220. Taking into account the obtained results of multiple criteria evaluation as well as EU and world trends in changing consumers’ habits including food safety and quality as well as customers’ preferences towards local market and local products, it is recommended that eggs

Product Family Modelling for Manufacturing Planning

DEFF Research Database (Denmark)

Jørgensen, Kaj Asbjørn; Petersen, Thomas Ditlev; Nielsen, Kjeld

2011-01-01

To enable product configuration of a product family, it is important to develop a model of the selected product family. From such a model, an often performed practice is to make a product configurator from which customers can specify individual products from the family. To get further utilisation...

On the flexibility of grammatical advance planning during sentence production: Effects of cognitive load on multiple lexical access.

Science.gov (United States)

Wagner, Valentin; Jescheniak, Jörg D; Schriefers, Herbert

2010-03-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers described 2-object displays with simple sentences of the form "the frog is next to the mug," the 2 nouns were found to be lexically-semantically activated to similar degrees at speech onset, as indexed by similarly sized interference effects from semantic distractors related to either the first or the second noun. When speakers used more complex sentences (including prenominal color adjectives; e.g., "the blue frog is next to the blue mug") much larger interference effects were observed for the first than the second noun, suggesting that the second noun was lexically-semantically activated before speech onset on only a subset of trials. With increased cognitive load, introduced by an additional conceptual decision task and variable utterance formats, the interference effect for the first noun was increased and the interference effect for second noun disappeared, suggesting that the scope of advance planning had been narrowed. By contrast, if cognitive load was induced by a secondary working memory task to be performed during speech planning, the interference effect for both nouns was increased, suggesting that the scope of advance planning had not been affected. In all, the data suggest that the scope of advance planning during grammatical encoding in sentence production is flexible, rather than structurally fixed.

The application of dynamic programming in production planning

Science.gov (United States)

Wu, Run

2017-05-01

Nowadays, with the popularity of the computers, various industries and fields are widely applying computer information technology, which brings about huge demand for a variety of application software. In order to develop software meeting various needs with most economical cost and best quality, programmers must design efficient algorithms. A superior algorithm can not only soul up one thing, but also maximize the benefits and generate the smallest overhead. As one of the common algorithms, dynamic programming algorithms are used to solving problems with some sort of optimal properties. When solving problems with a large amount of sub-problems that needs repetitive calculations, the ordinary sub-recursive method requires to consume exponential time, and dynamic programming algorithm can reduce the time complexity of the algorithm to the polynomial level, according to which we can conclude that dynamic programming algorithm is a very efficient compared to other algorithms reducing the computational complexity and enriching the computational results. In this paper, we expound the concept, basic elements, properties, core, solving steps and difficulties of the dynamic programming algorithm besides, establish the dynamic programming model of the production planning problem.

Understanding safety and production risks in rail engineering planning and protection.

Science.gov (United States)

Wilson, John R; Ryan, Brendan; Schock, Alex; Ferreira, Pedro; Smith, Stuart; Pitsopoulos, Julia

2009-07-01

Much of the published human factors work on risk is to do with safety and within this is concerned with prediction and analysis of human error and with human reliability assessment. Less has been published on human factors contributions to understanding and managing project, business, engineering and other forms of risk and still less jointly assessing risk to do with broad issues of 'safety' and broad issues of 'production' or 'performance'. This paper contains a general commentary on human factors and assessment of risk of various kinds, in the context of the aims of ergonomics and concerns about being too risk averse. The paper then describes a specific project, in rail engineering, where the notion of a human factors case has been employed to analyse engineering functions and related human factors issues. A human factors issues register for potential system disturbances has been developed, prior to a human factors risk assessment, which jointly covers safety and production (engineering delivery) concerns. The paper concludes with a commentary on the potential relevance of a resilience engineering perspective to understanding rail engineering systems risk. Design, planning and management of complex systems will increasingly have to address the issue of making trade-offs between safety and production, and ergonomics should be central to this. The paper addresses the relevant issues and does so in an under-published domain - rail systems engineering work.

Tailoring and field-testing the use of a knowledge translation peer support shared decision making strategy with First Nations, Inuit and Métis people making decisions about their cancer care: a study protocol.

Science.gov (United States)

Jull, Janet; Mazereeuw, Maegan; Sheppard, Amanada; Kewayosh, Alethea; Steiner, Richard; Graham, Ian D

2018-01-01

Tailoring and testing a peer support decision making strategy with First Nations, Inuit and Métis people making decisions about their cancer care: A study protocol.First Nations, Inuit and Métis (FNIM) people face higher risks for cancer compared to non-FNIM populations. They also face cultural barriers to health service use. Within non-FNIM populations an approach to health decision making, called shared decision making (SDM), has been found to improve the participation of people in their healthcare. Peer support with SDM further improves these benefits. The purpose of this study is to tailor and test a peer support SDM strategy with community support workers to increase FNIM people's participation in their cancer care.This project has two phases that will be designed and conducted with a Steering Committee that includes members of the FNIM and cancer care communities. First, a peer support SDM strategy will be tailored to meet the needs of cancer system users who are receiving care in urban settings, and training in the SDM strategy developed for community support workers. Three communities will be supported for participation in the study and community support workers who are peers from each community will be trained to use the SDM strategy.Next, each community support worker will work with a community member who has a diagnosis of cancer or who has supported a family member with cancer. Each community support worker and community member pair will use the SDM strategy. The participation and experience of the community support worker and community member will be evaluated.The research will be used to develop strategies to support people who are making decisions about their health. Tailoring and field-testing the use of a knowledge translation peer support shared decision making strategy with First Nations, Inuit and Métis people making decisions about their cancer care: A study protocol Background First Nations, Inuit and Métis ("FNIM") people face increased

My university. What I learned from the Productive Cooperative Movement to Promotion of Humanistic Family Planning.

Science.gov (United States)

Kunii, C

1990-07-01

Based on experiences with the Productive Cooperative Movement and the Parasite Control Movement in Japan, the Japanese Family Planning Movement began in April 1954. The resultant private and nonprofit Japan Family Planning Association (JFPA) followed and it served to help Japan achieve its goal of reducing fertility by promoting family planning. It did so by publishing a monthly newsletter on family planning, hosting meetings and national conventions, spreading information via the mass media, and selling contraceptives and educational materials. JFPA earned funding from these sales with no support from the government thereby establishing self dependence and freedom to speak candidly to the government. The JFPA learned that families wanted to improve their standard of living and were willing to limit family size to 2 children. After the birth rate peaked in 1955, the birth rate and the number of illegal abortions decreased. In the 1950s, JFPA joined the International Planned Parenthood Federation and subsequently learned of the problems faced by developing countries. Based on the successful reduction of fertility in Japan and a strong economic base, JFPA and the government were in a position to organize an international cooperation program for family planning. Therefore, the leader of JFPA resigned to found the Japanese Organization for International Cooperation in Family Planning which promotes family planning in developing countries via its integrated family planning, nutrition, and parasite control program. A steering committee composed of leaders from government, universities, and private organizations sets the policies for the program in each country. It is to the Japanese government's advantage to work with private organizations instead of providing all social services because they are flexible and provide administrative stability and national expenses are minimized.

Optimization-based guidelines to retirement planning and pension product design

DEFF Research Database (Denmark)

Konicz Bell, Agnieszka Karolina

their retirement savings, this thesis presents some optimization techniques that could be applied by pension providers and financial advisers to provide individuals with such guidelines. For a given objective function and a number of constraints, we search for the optimal solution, which indicates, for example...... investigate the optimal annuity choice under inflation risk, which is often ignored both by practitioners advising on the retirement planning and by scholars investigating the consumption-investment problems. We search for an optimal level of retirement income in real terms, given investment opportunities...... in inflation-linked, nominal, and variable annuities, as well as in stocks and bonds. Our findings show that real annuities are a crucial asset in every portfolio, and that trying to hedge inflation without investing in inflation-linked products leads to a lower and more volatile retirement income. In the last...

Optimizing a Biobjective Production-Distribution Planning Problem Using a GRASP

Directory of Open Access Journals (Sweden)

Martha-Selene Casas-Ramírez

2018-01-01

Full Text Available This paper addresses a biobjective production-distribution planning problem. The problem is formulated as a mixed integer programming problem with two objectives. The objectives are to minimize the total costs and to balance the total workload of the supply chain, which consist of plants and depots, considering that it represents a company vertically integrated. In order to solve the model, we propose an adapted biobjective GRASP to obtain an approximation of the Pareto front. To evaluate the performance of the proposed algorithm, numerical experimentations are conducted over a set of instances used for similar problems. Results indicate that the proposed GRASP obtains a relatively small number of nondominated solutions for each tested instance in very short computational time. The approximated Pareto fronts are discontinuous and nonconvex. Moreover, the solutions clearly show the compromise between both objective functions.

Simulation as a planning tool for job-shop production environment

Science.gov (United States)

Maram, Venkataramana; Nawawi, Mohd Kamal Bin Mohd; Rahman, Syariza Abdul; Sultan, Sultan Juma

2015-12-01

In this paper, we made an attempt to use discrete event simulation software ARENA® as a planning tool for job shop production environment. We considered job shop produces three types of Jigs with different sequence of operations to study and improve shop floor performance. The sole purpose of the study is to identifying options to improve machines utilization, reducing job waiting times at bottleneck machines. First, the performance of the existing system was evaluated by using ARENA®. Then identified improvement opportunities by analyzing base system results. Second, updated the model with most economical options. The proposed new system outperforms with that of the current base system by 816% improvement in delay times at paint shop by increase 2 to 3 and Jig cycle time reduces by Jig1 92%, Jig2 65% and Jig3 41% and hence new proposal was recommended.

Improving productivity and profitability of a bioanalytical business through sales and operation planning.

Science.gov (United States)

Islam, Rafiqul

2013-07-01

Today's bioanalytical CROs face increasing global competition, highly variable demand, high fixed costs, pricing pressure, and increasing demand for quality and speed. Most bioanalytical laboratories have responded to these challenges by implementing automation and by implementing process improvement methodologies (e.g., Six Sigma). These solutions have not resulted in a significant improvement in productivity and profitability since none of them are able to predict the upturn or downturn in demand. High volatility of demand causes long lead times and high costs during peak demand and poor productivity during trough demand. Most bioanalytical laboratories lack the tools to align supply efficiently to meet changing demand. In this paper, sales and operation planning (S&OP) has been investigated as a tool to balance supply and demand. The S&OP process, when executed effectively, can be the single greatest determinant of profitability for a bioanalytical business.

Economics, organization, and planning of drilling and petroleum-gas production enterprises. Ekonomika, organizatsiya, i planirovanie burovykh i neftegazo-dobyvayushchikh predpriyatii

Energy Technology Data Exchange (ETDEWEB)

Shmatov, V F; Tishchenko, V E; Malyshev, Yu M; Strizhenova, N F; Samigullin, A S

1978-01-01

An examination is made of problems in the economics, organization, planning, and management of production at drilling and petroleum-gas producing enterprises. A discussion is made of the development and distribution of the petroleum and gas industry, the essence and characteristics of technical progress in the petroleum industry, concentration, specialization, cooperation, and combination production. Considerable attention is given to fixed and working capital, productivity, principles of cost accounting, production costs, and economic reform. A discussion is made of the principles of organizing and managing a petroleum enterprise, labor management, technical labor standards, wage organization, planning of drilling and petroleum-gas production, principles of cost-accounting, inventory, and accountability. A discussion is made of the essence of methods of determining the economic effectiveness of production, and an examination is made of advanced methods of managing production, and basic problems in the economic analysis of production-management activities of enterprises. The book is intended as a textbook for students at secondary specialized teaching institutions dealing with the drilling and operation of petroleum and gas wells, the operation of oil and gas wells, and equipment of petroleum and gas industries. It may also be used by students in other fields of specialization as well as by workers in the petroleum and gas industry. 50 references, 5 figures, 55 tables.

Joint Optimal Production Planning for Complex Supply Chains Constrained by Carbon Emission Abatement Policies

OpenAIRE

He, Longfei; Xu, Zhaoguang; Niu, Zhanwen

2014-01-01

We focus on the joint production planning of complex supply chains facing stochastic demands and being constrained by carbon emission reduction policies. We pick two typical carbon emission reduction policies to research how emission regulation influences the profit and carbon footprint of a typical supply chain. We use the input-output model to capture the interrelated demand link between an arbitrary pair of two nodes in scenarios without or with carbon emission constraints. We design optim...

A 2nd generation static model for predicting greenhouse energy inputs, as an aid for production planning

CERN Document Server

Jolliet, O; Munday, G L

1985-01-01

A model which allows accurate prediction of energy consumption of a greenhouse is a useful tool for production planning and optimisation of greenhouse components. To date two types of model have been developed; some very simple models of low precision, others, precise dynamic models unsuitable for employment over long periods and too complex for use in practice. A theoretical study and measurements at the CERN trial greenhouse have allowed development of a new static model named "HORTICERN", easy to use and as precise as more complex dynamic models. This paper demonstrates the potential of this model for long-term production planning. The model gives precise predictions of energy consumption when given greenhouse conditions of use (inside temperatures, dehumidification by ventilation, …) and takes into account local climatic conditions (wind radiative losses to the sky and solar gains), type of greenhouse (cladding, thermal screen …). The HORTICERN method has been developed for PC use and requires less...

Hierarchical Planning Methodology for a Supply Chain Management

Directory of Open Access Journals (Sweden)

Virna ORTIZ-ARAYA

2012-01-01

Full Text Available Hierarchical production planning is a widely utilized methodology for real world capacitated production planning systems with the aim of establishing different decision–making levels of the planning issues on the time horizon considered. This paper presents a hierarchical approach proposed to a company that produces reusable shopping bags in Chile and Perú, to determine the optimal allocation of resources at the tactical level as well as over the most immediate planning horizon to meet customer demands for the next weeks. Starting from an aggregated production planning model, the aggregated decisions are disaggregated into refined decisions in two levels, using a couple of optimization models that impose appropriate constraints to keep coherence of the plan on the production system. The main features of the hierarchical solution approach are presented.

Applying the theory of planned behavior to predict dairy product consumption by older adults.

Science.gov (United States)

Kim, Kyungwon; Reicks, Marla; Sjoberg, Sara

2003-01-01

The purpose of this study was to explain intention to consume dairy products and consumption of dairy products by older adults using the Theory of Planned Behavior (TPB). The factors examined were attitudes, subjective norms, and perceived behavioral control. A cross-sectional questionnaire was administered. Community centers with congregate dining programs, group classes, and recreational events for older adults. One hundred and sixty-two older adults (mean age 75 years) completed the questionnaire. Subjects were mostly women (76%) and white (65%), with about half having less than a high school education or completing high school. Variables based on the TPB were assessed through questionnaire items that were constructed to form scales measuring attitudes, subjective norms, perceived behavioral control, and intention to consume dairy products. Dairy product consumption was measured using a food frequency questionnaire. Regression analyses were used to determine the association between the scales for the 3 variables proposed in the TPB and intention to consume and consumption of dairy products; the alpha level was set at.05 to determine the statistical significance of results. Attitudes toward eating dairy products and perceived behavioral control contributed to the model for predicting intention, whereas subjective norms did not. Attitudes toward eating dairy products were slightly more important than perceived behavioral control in predicting intention. In turn, intention was strongly related to dairy product consumption, and perceived behavioral control was independently associated with dairy product consumption. These results suggest the utility of the TPB in explaining dairy product consumption for older adults. Nutrition education should focus on improving attitudes and removing barriers to consumption of dairy products for older adults.

On the Flexibility of Grammatical Advance Planning During Sentence Production: Effects of Cognitive Load on Multiple Lexical Access

NARCIS (Netherlands)

Wagner, V.; Jescheniak, J.D.; Schriefers, H.J.

2010-01-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers

FRESHWATER FISH FARMING CONDITIONS IN 1999 AND THE PRODUCTION PLAN FOR 2000

Directory of Open Access Journals (Sweden)

Zlatko Homen

2000-09-01

Full Text Available One of the activities of the Ministry of Agriculture and Forestry, Fishery and Mediterranean Agriculture Directorate, i. e. Fishery Directorate to be more specific, is the monitoring of conditions in freshwater fish farming. The objective of this work is to show conditions in freshwater fish farming during 1999. and to provide a production plan for 2000. It will also provide detailed insight into the present conditions in freshwater fish farming and into the production trends of this field. Regarding this issue, the »Questionnaire for the Monitoring of Conditions in Freshwater Fish Farming«, was sent to fish farmers aroud the country data was processed from 22 cap ponds and 13 trout ponds. Roughe estimates of conditions were conducted for 2 fish farms, since they haven’t yet returned the mandatoruy questionnaire, i. e. the necessary data. This work features data on the number of employees in fish farms, as well as their qualifications, on the actual production and distribution of farmed freshwater fish, on the areas where production was conducted and on the overall yield. Fish food, raw materials, used tools and incentive funds paid were also taken into consideration. The difficulties faced in this branch of the economy are also inicated. Compared to 1998, a slight decrease in the number of employees of freshwater fish farms has been recorded. The total number of employees in 1999 was 655, of which 555 were on carp ponds and 100 on trout ponds. Data on the qualifications of employees for 1999 show that most of them were unskilled workers, while highly skilled workers make up a minority in this work force. The total production of freshwater in 1999. amoounted to 6.185,51 tons. Of this amount 5.592,52 tons were warm-water fish specied and 592,99 tons were cold-water fish species. Compared to 1998, production decreased by 4,89 percent. Production for 2000 has been planned to increase by 22,15 percent, i. e. the production quantity is projected

From lagging to leading? Technological innovation systems in emerging economies and the case of Chinese wind power

International Nuclear Information System (INIS)

Gosens, Jorrit; Lu, Yonglong

2013-01-01

There is increasing attention for the contribution of emerging economies to global innovation, including innovation of renewable energy technologies. The Technological Innovation Systems (TIS) framework presents a list of system functions for the analysis of the development of a technology. It has often been applied to renewable energy technologies, but with a strong focus on advanced economies. In this paper, we elaborate on emerging economy innovation system formation, structured according to TIS functions. Rather than analysing development of the technology, we analyse the development of the Chinese TIS vis-à-vis the global forefront. Key to this notion is that TIS, especially for clean-tech, are transnational phenomena. Lagging TIS depend on the global TIS, whereas leading TIS contribute to its formation. It is concluded that China has reduced its dependence on foreign knowledge and investment, but the outward contribution remains limited. The main challenge to foreign market expansion lies in reforming the domestic TIS to focus on turbine quality rather than cost reduction. Demonstration projects are needed, especially for large capacity and offshore turbine models, in order to build up operational history and get quality certification. - Highlights: • The TIS framework was adapted to suit emerging economy case studies. • China's wind power TIS is emerging vis-à-vis the global forefront. • China's wind power TIS has reduced its dependence on foreign knowledge and finance. • Chinese innovative activity for wind power remains limited to the domestic context. • Foreign market expansion requires a focus on turbine quality and certification

Business Plan for a Record Company

OpenAIRE

Mbuthia, Alexander; Wakuwile, Janina

2013-01-01

The objective of this thesis is to develop a business plan for a record company named Kamoja Records in Espoo Finland that will focus on music and video production. The main purpose of this study is to determine whether this business plan is viable and whether the resulting company would be able to function as a vibrant record label. The business plan evaluates different features that are related to music and video production. The purpose is to obtain knowledge about business planning in gene...

[Investigating phonological planning processes in speech production through a speech-error induction technique].

Science.gov (United States)

Nakayama, Masataka; Saito, Satoru

2015-08-01

The present study investigated principles of phonological planning, a common serial ordering mechanism for speech production and phonological short-term memory. Nakayama and Saito (2014) have investigated the principles by using a speech-error induction technique, in which participants were exposed to an auditory distracIor word immediately before an utterance of a target word. They demonstrated within-word adjacent mora exchanges and serial position effects on error rates. These findings support, respectively, the temporal distance and the edge principles at a within-word level. As this previous study induced errors using word distractors created by exchanging adjacent morae in the target words, it is possible that the speech errors are expressions of lexical intrusions reflecting interactive activation of phonological and lexical/semantic representations. To eliminate this possibility, the present study used nonword distractors that had no lexical or semantic representations. This approach successfully replicated the error patterns identified in the abovementioned study, further confirming that the temporal distance and edge principles are organizing precepts in phonological planning.

The Effect of Online Planning, Strategic Planning and Rehearsal across Two Proficiency Levels

Science.gov (United States)

Baleghizadeh, Sasan; Shahri, Mohammad Naseh Nasrollahi

2017-01-01

The study presents an investigation of the effect of strategic planning, online planning and rehearsal on the fluency, accuracy and complexity of oral productions at two proficiency levels. Forty EFL participants at low and intermediate levels performed picture story tasks in three different conditions: the online planning only condition,…

Technology Planning Strategies

Science.gov (United States)

Decker, Kathy

2004-01-01

Effective planning strategies drive achievement of an overall technology goal to increase access to electronic information in real time in order to increase efficiency, productivity, and communication across campus. Planning relies on providing access, 'Anytime Anywhere' to student information, calendar, email, course management tools, and the…

Rolling schedule approaches for supply chain operations planning

NARCIS (Netherlands)

Spitter, J.M.

2005-01-01

Supply Chain Operations Planning (SCOP) involves the determination of an extensive production plan for a network of manufacturing and distribution entities within and across organizations. The production plan consist of order release decisions that allocate materials and resources in order to

To plan or not to plan: Does planning for production remove facilitation from associative priming?

NARCIS (Netherlands)

Jongman, S.R.; Meyer, A.S.

2017-01-01

Theories of conversation propose that in order to have smooth transitions from one turn to the next, speakers already plan their response while listening to their interlocutor. Moreover, it has been argued that speakers align their linguistic representations (i.e. prime each other), thereby reducing

Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure.

Science.gov (United States)

Mann, Marita; Diero, Lameck; Kemboi, Emmanuel; Mambo, Fidelis; Rono, Mary; Injera, Wilfred; Delong, Allison; Schreier, Leeann; Kaloustian, Kara W; Sidle, John; Buziba, Nathan; Kantor, Rami

2013-10-01

Antiretroviral treatment interruptions (TIs) cause suboptimal clinical outcomes. Data on TIs during social disruption are limited. We determined effects of unplanned TIs after the 2007-2008 Kenyan postelection violence on virological failure, comparing viral load (VL) outcomes in HIV-infected adults with and without conflict-induced TI. Two hundred and one patients were enrolled, median 2.2 years after conflict and 4.3 years on treatment. Eighty-eight patients experienced conflict-related TIs and 113 received continuous treatment. After adjusting for preconflict CD4, patients with TIs were more likely to have detectable VL, VL >5,000 and VL >10,000. Unplanned conflict-related TIs are associated with increased likelihood of virological failure.

Verification of a Method for Measuring Parkinson’s Disease Related Temporal Irregularity in Spiral Drawings

Directory of Open Access Journals (Sweden)

Somayeh Aghanavesi

2017-10-01

Full Text Available Parkinson’s disease (PD is a progressive movement disorder caused by the death of dopamine-producing cells in the midbrain. There is a need for frequent symptom assessment, since the treatment needs to be individualized as the disease progresses. The aim of this paper was to verify and further investigate the clinimetric properties of an entropy-based method for measuring PD-related upper limb temporal irregularities during spiral drawing tasks. More specifically, properties of a temporal irregularity score (TIS for patients at different stages of PD, and medication time points were investigated. Nineteen PD patients and 22 healthy controls performed repeated spiral drawing tasks on a smartphone. Patients performed the tests before a single levodopa dose and at specific time intervals after the dose was given. Three movement disorder specialists rated videos of the patients based on the unified PD rating scale (UPDRS and the Dyskinesia scale. Differences in mean TIS between the groups of patients and healthy subjects were assessed. Test-retest reliability of the TIS was measured. The ability of TIS to detect changes from baseline (before medication to later time points was investigated. Correlations between TIS and clinical rating scores were assessed. The mean TIS was significantly different between healthy subjects and patients in advanced groups (p-value = 0.02. Test-retest reliability of TIS was good with Intra-class Correlation Coefficient of 0.81. When assessing changes in relation to treatment, TIS contained some information to capture changes from Off to On and wearing off effects. However, the correlations between TIS and clinical scores (UPDRS and Dyskinesia were weak. TIS was able to differentiate spiral drawings drawn by patients in an advanced stage from those drawn by healthy subjects, and TIS had good test-retest reliability. TIS was somewhat responsive to single-dose levodopa treatment. Since TIS is an upper limb high

The Effects of Simultaneous Use of Careful Online Planning and Task Repetition on Accuracy, Complexity, and Fluency in EFL Learners' Oral Production

Science.gov (United States)

Ahmadian, Mohammad Javad; Tavakoli, Mansoor

2011-01-01

This article reports on a study that was primarily aimed at investigating the effects of simultaneous use of careful online planning and task repetition on accuracy, complexity, and fluency in the oral production of learners of English as a foreign language (EFL). The effects of four planning and task repetition conditions (i.e. careful online…

Word Order and Voice Influence the Timing of Verb Planning in German Sentence Production.

Science.gov (United States)

Sauppe, Sebastian

2017-01-01

Theories of incremental sentence production make different assumptions about when speakers encode information about described events and when verbs are selected, accordingly. An eye tracking experiment on German testing the predictions from linear and hierarchical incrementality about the timing of event encoding and verb planning is reported. In the experiment, participants described depictions of two-participant events with sentences that differed in voice and word order. Verb-medial active sentences and actives and passives with sentence-final verbs were compared. Linear incrementality predicts that sentences with verbs placed early differ from verb-final sentences because verbs are assumed to only be planned shortly before they are articulated. By contrast, hierarchical incrementality assumes that speakers start planning with relational encoding of the event. A weak version of hierarchical incrementality assumes that only the action is encoded at the outset of formulation and selection of lexical verbs only occurs shortly before they are articulated, leading to the prediction of different fixation patterns for verb-medial and verb-final sentences. A strong version of hierarchical incrementality predicts no differences between verb-medial and verb-final sentences because it assumes that verbs are always lexically selected early in the formulation process. Based on growth curve analyses of fixations to agent and patient characters in the described pictures, and the influence of character humanness and the lack of an influence of the visual salience of characters on speakers' choice of active or passive voice, the current results suggest that while verb planning does not necessarily occur early during formulation, speakers of German always create an event representation early.

The Comparison of Layout Arrangements for the Material Flow Ordering Planning in Production Systems through Simulation Analysis

Directory of Open Access Journals (Sweden)

Mehmet AKSARAYLI

2009-02-01

Full Text Available Enterprises have to make suitable location planning to decrease their product cost and to increase their productivity in our time. The aim of this study is to compare the basic layout types used in arranging inside facility layout with each other by using simulation. Especially in this study, material handling times between machines and ratio of these times in total times were interested. First of all a new production system is designed to the basic layout types used in arranging inside facility layout. And then in the designed production system, machines are arranged for each machine layout types. Machine layout types are transferred to PROMODEL simulation software. Then with the results of analysis, material handling times of different machine layout types and ratio of material handling times in total production time were compared and the results obtained from this analysis were given after commented on this study.

Designing of network planning system for small-scale manufacturing

Science.gov (United States)

Kapulin, D. V.; Russkikh, P. A.; Vinnichenko, M. V.

2018-05-01

The paper presents features of network planning in small-scale discrete production. The procedure of explosion of the production order, considering multilevel representation, is developed. The software architecture is offered. Approbation of the network planning system is carried out. This system allows carrying out dynamic updating of the production plan.

Planning and tracking chemotherapy production for cancer treatment: a performing and integrated solution.

Science.gov (United States)

Kergosien, Y; Tournamille, J-F; Laurence, B; Billaut, J-C

2011-09-01

Chemotherapy drugs are intended for the treatment of cancer. The production of such drugs and their administration to the patient is a delicate and expensive operation. The study deals with the acquisition and processing of data regarding the production of intravenous chemotherapy, from the production request (the medical prescription), the production itself (pharmaceutical process), to the delivery in the health care unit, for the administration of the chemotherapy. The goal of this study is to develop a system that can schedule, control and track the chemotherapy preparations and satisfy a certification process of quality management ("ISO 9001 version 2000" standard). The solution proposed in this paper was developed within the framework of a common certification process at the Biopharmaceutical Unit of the Oncology Clinic (UBCO) of the Bretonneau hospital in Tours (France). The system consists of two software programs: a software to insure traceability and a decision making software to plan the production. To simplify the data entry process, some mobile entry points with bar code reader have been deployed. These tools enable an accurate tracking of the production, a security and control for the schedule production phases, and a full traceability of each operation leading to the administration of the chemotherapy drug. The first result is a software that creates the production schedule, allows a real time control of the production process and a full traceability of each step. Computational experiments are based on real data sets, with a comparison of a time period before and after the implementation of this solution. The results show the positive impacts of this software, like the reduction of delayed deliveries, real time generation of production indicators, optimization of the production and a saving of staff time. This intuitive system guarantees a traceability in connection with a high quality system certified ISO 9001-v2000 (with a rapid data entry), an

The segment as the minimal planning unit in speech production and reading aloud: evidence and implications.

Science.gov (United States)

Kawamoto, Alan H; Liu, Qiang; Kello, Christopher T

2015-01-01

Speech production and reading aloud studies have much in common, especially the last stages involved in producing a response. We focus on the minimal planning unit (MPU) in articulation. Although most researchers now assume that the MPU is the syllable, we argue that it is at least as small as the segment based on negative response latencies (i.e., response initiation before presentation of the complete target) and longer initial segment durations in a reading aloud task where the initial segment is primed. We also discuss why such evidence was not found in earlier studies. Next, we rebut arguments that the segment cannot be the MPU by appealing to flexible planning scope whereby planning units of different sizes can be used due to individual differences, as well as stimulus and experimental design differences. We also discuss why negative response latencies do not arise in some situations and why anticipatory coarticulation does not preclude the segment MPU. Finally, we argue that the segment MPU is also important because it provides an alternative explanation of results implicated in the serial vs. parallel processing debate.

On the Flexibility of Grammatical Advance Planning during Sentence Production: Effects of Cognitive Load on Multiple Lexical Access

Science.gov (United States)

Wagner, Valentin; Jescheniak, Jorg D.; Schriefers, Herbert

2010-01-01

Three picture-word interference experiments addressed the question of whether the scope of grammatical advance planning in sentence production corresponds to some fixed unit or rather is flexible. Subjects produced sentences of different formats under varying amounts of cognitive load. When speakers described 2-object displays with simple…

Policy plan for the early approval for irradiated meat products and the promotion of irradiated meats in market

Energy Technology Data Exchange (ETDEWEB)

Lee, Ju Woon [Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Kim, Wang Geun [Ministry of Education, Science and Technology, Seoul (Korea, Republic of); Kim, Kyong Su [Dept. of Food and Nutrition, Chosun University, Gwangju (Korea, Republic of); Yook, Hong Sun [Dept. of Food and Nutrition, Chungnam National University, Daejeon (Korea, Republic of); Kim, Cheon Jei [Division of Animal Life Science, Konkuk University, Seoul (Korea, Republic of)

2008-11-15

The consumption of meat products is gradually being increased by the development of livestock raising technology, industrialized farm management and international trade. This increased consumption also created new market for ready-to-eat and ready-to-cook meat products. However, these convenience meat products can be easily contaminated during the processing and storage by pathogens, and there have been many reported cases of food borne illness by meats. One of the most effective methods for the decontamination of meat products is the radiation technology. Food irradiation was the established, well-recognized and safe sterilization method. Many other countries researched the effect of irradiation on the meat products and approved the irradiation. In this article, the effectiveness, the international acceptance, the economics and the research trend of irradiation on meat products have been reviewed. Also, the policy plans for the early approval of the irradiated meat products in Korea and the promotion policy of irradiated meats in market were discussed.

Policy plan for the early approval for irradiated meat products and the promotion of irradiated meats in market

International Nuclear Information System (INIS)

Lee, Ju Woon; Kim, Wang Geun; Kim, Kyong Su; Yook, Hong Sun; Kim, Cheon Jei

2008-01-01

The consumption of meat products is gradually being increased by the development of livestock raising technology, industrialized farm management and international trade. This increased consumption also created new market for ready-to-eat and ready-to-cook meat products. However, these convenience meat products can be easily contaminated during the processing and storage by pathogens, and there have been many reported cases of food borne illness by meats. One of the most effective methods for the decontamination of meat products is the radiation technology. Food irradiation was the established, well-recognized and safe sterilization method. Many other countries researched the effect of irradiation on the meat products and approved the irradiation. In this article, the effectiveness, the international acceptance, the economics and the research trend of irradiation on meat products have been reviewed. Also, the policy plans for the early approval of the irradiated meat products in Korea and the promotion policy of irradiated meats in market were discussed

Configuration Management Program Plan

International Nuclear Information System (INIS)

1991-01-01

Westinghouse Savannah River Company (WSRC) has established a configuration management (CM) plan to execute the SRS CM Policy and the requirements of the DOE Order 4700.1. The Reactor Restart Division (RRD) has developed its CM Plan under the SRS CM Program and is implementing it via the RRD CM Program Plan and the Integrated Action Plan. The purpose of the RRD CM program is to improve those processes which are essential to the safe and efficient operation of SRS production reactors. This document provides details of this plan

Focos sépticos bucales en pacientes con uveítis Oral sepsis in patients with uveitis

Directory of Open Access Journals (Sweden)

Maritza Peña Sisto

2012-12-01

Full Text Available Se realizó un estudio descriptivo y transversal de 26 pacientes con uveítis, atendidos en el Servicio de Estomatología del Hospital General Docente "Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde mayo hasta diciembre del 2011, con vistas a describir las infecciones bucales frecuentemente asociadas a dicha afección y la importancia del tratamiento estomatológico en estos enfermos. La información se obtuvo de las entrevistas y las historias clínicas; además, se realizó examen físico intrabucal y estudio radiográfico para diagnosticar y tratar la presencia de caries, procesos periapicales, procesos pulpares y enfermedades periodontales. Se empleó el programa SPSS versión 10.0 y como medidas de resumen, los índices y los porcentajes. Todos los afectados presentaron algún tipo de infección bucal, con mayor frecuencia de las periodontitis y los procesos periapicales en dientes posteriores del maxilar superior. La agudeza visual tuvo gran mejoría debido al tratamiento conjunto oftalmológico y estomatológico.A descriptive and cross-sectional study was carried out in 26 patients with uveitis, treated at the Stomatology Department of "Juan Bruno Zayas Alfonso" Teaching General Hospital in Santiago de Cuba from May to December 2011, in order to describe oral infections often associated with this condition and the importance of dental treatment in these patients. Data were obtained from interviews and medical records. Moreover, oral examination and radiographic study were performed to diagnose and treat dental caries, periapical and pulpal conditions and periodontal diseases. The software SPSS version 10.0 and rates and percentages as summary measure were used. All patients had some type of oral infection with increased frequency of periodontitis and periapical conditions in posterior maxillary teeth. Visual acuity greatly improved due to combined dental and ophthalmological treatment.

The Effects of Guided Careful Online Planning on Complexity, Accuracy and Fluency in Intermediate EFL Learners' Oral Production: The Case of English Articles

Science.gov (United States)

Ahmadian, Mohammad Javad

2012-01-01

The purpose of the study reported in this article was twofold: First, to see whether guided careful online planning assists intermediate learners of English as a foreign language (EFL) in accurate oral production of English articles ("an/a" and "the"); and, second, to see whether guided careful online planning has any effects…

A planning concept incorporating the knowledge of both planning and operations personnel

Energy Technology Data Exchange (ETDEWEB)

Valenca, M M; Nepomuceno, L; Teixeira, J C.F.; Santos, Junior, A [Universidade Estadual de Campinas, SP (Brazil)

1994-12-31

In this paper, the electrical operation planning problem and the available technological possibilities for the improvement of planner`s work process are analyzed. The importance of the expert`s experience in efficient operation plans production is pointed out. The useful knowledge in planning and operating environments and their automation by Artificial Intelligence techniques are evaluated. Finally, conception of a decision-making support system allowing the interaction of storage expertise with analysis programs proposed, in order to improve the planning process. (author) 15 refs., 4 figs.

Word Order and Voice Influence the Timing of Verb Planning in German Sentence Production

Directory of Open Access Journals (Sweden)

Sebastian Sauppe

2017-09-01

Full Text Available Theories of incremental sentence production make different assumptions about when speakers encode information about described events and when verbs are selected, accordingly. An eye tracking experiment on German testing the predictions from linear and hierarchical incrementality about the timing of event encoding and verb planning is reported. In the experiment, participants described depictions of two-participant events with sentences that differed in voice and word order. Verb-medial active sentences and actives and passives with sentence-final verbs were compared. Linear incrementality predicts that sentences with verbs placed early differ from verb-final sentences because verbs are assumed to only be planned shortly before they are articulated. By contrast, hierarchical incrementality assumes that speakers start planning with relational encoding of the event. A weak version of hierarchical incrementality assumes that only the action is encoded at the outset of formulation and selection of lexical verbs only occurs shortly before they are articulated, leading to the prediction of different fixation patterns for verb-medial and verb-final sentences. A strong version of hierarchical incrementality predicts no differences between verb-medial and verb-final sentences because it assumes that verbs are always lexically selected early in the formulation process. Based on growth curve analyses of fixations to agent and patient characters in the described pictures, and the influence of character humanness and the lack of an influence of the visual salience of characters on speakers' choice of active or passive voice, the current results suggest that while verb planning does not necessarily occur early during formulation, speakers of German always create an event representation early.

Synchronous method and engineering tool for the strategic factory planning

OpenAIRE

Abdul Rahman, O.; Jaeger, J.; Constantinescu, C.

2011-01-01

This paper presents the approach to combine two reference methods and engineering tools, for "Factory Performance and Investment Planning«as well as "Value Added Ideal Production Network Planning". The resulted synchronous method aims to support factories in the strategic planning as well as in the network planning. The corresponding engineering tool is employed for assessment planning, sales planning, capacity planning and production costs planning under the consideration of dynamic and stoc...

Interactions and Supramolecular Organization of Sulfonated Indigo and Thioindigo Dyes in Layered Hydroxide Hosts.

Science.gov (United States)

Costa, Ana L; Gomes, Ana C; Pereira, Ricardo C; Pillinger, Martyn; Gonçalves, Isabel S; Pineiro, Marta; Seixas de Melo, J Sérgio

2018-01-09

Supramolecularly organized host-guest systems have been synthesized by intercalating water-soluble forms of indigo (indigo carmine, IC) and thioindigo (thioindigo-5,5'-disulfonate, TIS) in zinc-aluminum-layered double hydroxides (LDHs) and zinc-layered hydroxide salts (LHSs) by coprecipitation routes. The colors of the isolated powders were dark blue for hybrids containing only IC, purplish blue or dark lilac for cointercalated samples containing both dyes, and ruby/wine for hybrids containing only TIS. The as-synthesized and thermally treated materials were characterized by Fourier transform infrared, Fourier transform Raman, and nuclear magnetic resonance spectroscopies, powder X-ray diffraction, scanning electron microscopy, and elemental and thermogravimetric analyses. The basal spacings found for IC-LDH, TIS-LDH, IC-LHS, and TIS-LHS materials were 21.9, 21.05, 18.95, and 21.00 Å, respectively, with intermediate spacings being observed for the cointercalated samples that either decreased (LDHs) or increased (LHSs) with increasing TIS content. UV-visible and fluorescence spectroscopies (steady-state and time-resolved) were used to probe the molecular distribution of the immobilized dyes. The presence of aggregates together with the monomer units is suggested for IC-LDH, whereas for TIS-LDH, IC-LHS, and TIS-LHS, the dyes are closer to the isolated situation. Accordingly, while emission from the powder H 2 TIS is strongly quenched, an increment in the emission of about 1 order of magnitude was observed for the TIS-LDH/LHS hybrids. Double-exponential fluorescence decays were obtained and associated with two monomer species interacting differently with cointercalated water molecules. The incorporation of both TIS and IC in the LDH and LHS hosts leads to an almost complete quenching of the fluorescence, pointing to a very efficient energy transfer process from (fluorescent) TIS to (nonfluorescent) IC.

A draft business plan for the production of PZC 99Mo-99mTc generator in the Philippines

International Nuclear Information System (INIS)

Sombrito, Elvira Z.; Cabalfin, Estelita G.; Calix, Virginia S.; Dela Rosa, Alumanda M.; Borras, Ma. Teresa L.; Bulos, Adelina dM.

2007-01-01

Technetium-99m ( 99m Tc) remains as the main workhorse of nuclear medicine in the country. Alone or conjugated with other ligands, it is being used to show the function of major organs and other tissues such as the lung, brain, kidney, liver and bone. It is imported to the country as 99 Mo- 99m Tc generator. These commercial generators use fission molybdenum adsorbed onto alumina column. The FNCA project has shown the feasibility of using a PZC column-reactor 99 Mo generator for commercial applications, citing mainly the cheaper cost of the PZC generator than the imported alumina column-fission 99 Mo generator. PNRI proposes in this draft business plan, the commercial production of PZC generator through the establishment of a facility for the in-house production of 99 Mo- 99m Tc generator. The generator will use PZC coming from Japan as the column material, 99 Mo sourced from neighboring countries and an automatic loading and adsorption machine. Because the PNRI has no local production of the generator, the requirements for successfully venturing into this business activity may differ from the other FNCA members. A careful assessment based on verified data will be needed to refine the business plan. (author)

Contingency planning: preparation of contingency plans

DEFF Research Database (Denmark)

Westergaard, J M

2008-01-01

. The risk of introducing disease pathogens into a country and the spread of the agent within a country depends on a number of factors including import controls, movement of animals and animal products and the biosecurity applied by livestock producers. An adequate contingency plan is an important instrument...... in the preparation for and the handling of an epidemic. The legislation of the European Union requires that all Member States draw up a contingency plan which specifies the national measures required to maintain a high level of awareness and preparedness and is to be implemented in the event of disease outbreak...

Quinault Indian Nation Renewable Energy Plan

Energy Technology Data Exchange (ETDEWEB)

Don Hopps, Institute for Washington' s Future; Jesse Nelson, Institute for Washington' s Future

2006-11-28

The Quinault Indian Nation (Nation) initiated this study on conservation and production of renewable energy because this approach created the opportunity: • To become self-sufficient and gain greater control over the energy the Nation uses; • To generate jobs and businesses for its members; • To better manage, sustain, and protect its resources; • To express the cultural values of the Nation in an important new arena. The Nation has relatively small energy needs. These needs are concentrated at two separate points: the Quinault Beach Resort and Casino (QBRC) and Taholah on the Quinault Indian Reservation (QIR). Except for the town of Queets, energy needs are small and scattered. The needs vary greatly over the season. The small scale, widely dispersed, and variable nature of these needs presents a unique challenge to the Nation. Meeting these needs requires a resource and technology that is flexible, effective, and portable. Conservation is the most cost-effective way to meet any need. It is especially effective in a situation like this where production would leave a high per unit cost. This plan is based on first gaining energy savings through conservation. Major savings are possible through: 1. Upgrading home appliances on the QIR. 2. Weatherizing homes and facilities. 3. Changes in lighting/ventilation in the QBRC pool room. These elements of the plan are already being implemented and promise to save the Nation around a quarter of its present costs. Wood biomass is the best resource available to the QIN for energy production either on-site or for commercial development. It is abundant, flexible and portable. Its harvesting has high job potential and these jobs are a good fit for the present “skill set” of the QIN. This plan focuses on using wood biomass to produce energy and other value-added products. Our study considered various technologies and approaches to using wood for energy. We considered production for both on-site and commercial production

Shared decision-making and health for First Nations, Métis and Inuit women: a study protocol

Directory of Open Access Journals (Sweden)

Jull Janet

2012-12-01

Full Text Available Abstract Background Little is known about shared decision-making (SDM with Métis, First Nations and Inuit women (“Aboriginal women”. SDM is a collaborative process that engages health care professional(s and the client in making health decisions and is fundamental for informed consent and patient-centred care. The objective of this study is to explore Aboriginal women’s health and social decision-making needs and to engage Aboriginal women in culturally adapting an SDM approach. Methods Using participatory research principles and guided by a postcolonial theoretical lens, the proposed mixed methods research will involve three phases. Phase I is an international systematic review of the effectiveness of interventions for Aboriginal peoples’ health decision-making. Developed following dialogue with key stakeholders, proposed methods are guided by the Cochrane handbook and include a comprehensive search, screening by two independent researchers, and synthesis of findings. Phases II and III will be conducted in collaboration with Minwaashin Lodge and engage an urban Aboriginal community of women in an interpretive descriptive qualitative study. In Phase II, 10 to 13 Aboriginal women will be interviewed to explore their health/social decision-making experiences. The interview guide is based on the Ottawa Decision Support Framework and previous decisional needs assessments, and as appropriate may be adapted to findings from the systematic review. Digitally-recorded interviews will be transcribed verbatim and analyzed inductively to identify participant decision-making approaches and needs when making health/social decisions. In Phase III, there will be cultural adaptation of an SDM facilitation tool, the Ottawa Personal Decision Guide, by two focus groups consisting of five to seven Aboriginal women. The culturally adapted guide will undergo usability testing through individual interviews with five to six women who are about to make a health

Optimizing decentralized production-distribution planning problem in a multi-period supply chain network under uncertainty

Science.gov (United States)

Nourifar, Raheleh; Mahdavi, Iraj; Mahdavi-Amiri, Nezam; Paydar, Mohammad Mahdi

2017-09-01

Decentralized supply chain management is found to be significantly relevant in today's competitive markets. Production and distribution planning is posed as an important optimization problem in supply chain networks. Here, we propose a multi-period decentralized supply chain network model with uncertainty. The imprecision related to uncertain parameters like demand and price of the final product is appropriated with stochastic and fuzzy numbers. We provide mathematical formulation of the problem as a bi-level mixed integer linear programming model. Due to problem's convolution, a structure to solve is developed that incorporates a novel heuristic algorithm based on Kth-best algorithm, fuzzy approach and chance constraint approach. Ultimately, a numerical example is constructed and worked through to demonstrate applicability of the optimization model. A sensitivity analysis is also made.

Implementation plan for the new production reactor capacity environmental impact statement

International Nuclear Information System (INIS)

1989-12-01

The US Department of Energy (DOE) proposed to site, construct, and operate new production reactor (NPR) capacity intended primarily to produce tritium and secondarily to produce plutonium for the US nuclear weapons program. DOE studies show that this new capacity is needed to ensure reliable maintenance of the nation's nuclear weapons stockpile. It also is essential that these necessary nuclear materials be produced in a safe and environmentally sound manner. The DOE has determined that this proposed action constitutes a major federal action that may significantly affect the quality of the human environment; therefore, the DOE will prepare an environmental impact statement (EIS) to assess the potential impacts of the proposed action and reasonable alternatives on the human and natural environment. The EIS will be prepared in accordance with the National Environmental Policy Act of 1969, as implemented in regulations promulgated by the Council on Environmental Quality (CEQ). This EIS implementation plan (IP) includes a description of the proposed action, descriptions of alternatives, a summary of EIS assumptions, a list of environmental issues to be considered in the EIS (including those identified during public scoping activities), a list of proposed agency consultations, a schedule for EIS preparation and related activities, and an annotated outline for the EIS. It is the Department's intent that the EIS on the NPR capacity will serve as the programmatic National Environmental Policy Act (NEPA) review of modernization of DOE defense nuclear materials production of tritium and plutonium. The Department is currently developing a NEPA compliance strategy for modernization of the remainder of the nuclear weapons production complex, which will reference the EIS on NPR capacity. 7 refs., 8 tabs

Developing a New North American Land Cover Product at 30m Resolution: Methods, Results and Future Plans

Science.gov (United States)

Homer, C.; Colditz, R. R.; Latifovic, R.; Llamas, R. M.; Pouliot, D.; Danielson, P.; Meneses, C.; Victoria, A.; Ressl, R.; Richardson, K.; Vulpescu, M.

2017-12-01

Land cover and land cover change information at regional and continental scales has become fundamental for studying and understanding the terrestrial environment. With recent advances in computer science and freely available image archives, continental land cover mapping has been advancing to higher spatial resolution products. The North American Land Change Monitoring System (NALCMS) remains the principal provider of seamless land cover maps of North America. Founded in 2006, this collaboration among the governments of Canada, Mexico and the United States has released two previous products based on 250m MODIS images, including a 2005 land cover and a 2005-2010 land cover change product. NALCMS has recently completed the next generation North America land cover product, based upon 30m Landsat images. This product now provides the first ever 30m land cover produced for the North American continent, providing 19 classes of seamless land cover. This presentation provides an overview of country-specific image classification processes, describes the continental map production process, provides results for the North American continent and discusses future plans. NALCMS is coordinated by the Commission for Environmental Cooperation (CEC) and all products can be obtained at their website - www.cec.org.

Retail Tactical Planning: An Aligned Process?

OpenAIRE

Dreyer , Heidi; Dukovska-Popovska , Iskra; Kiil , Kasper; Kaipia , Riikka

2016-01-01

Part 9: Quality in Production Management; International audience; This paper addresses tactical planning in retailing through a case study approach in one grocery retailing company. The issues are how tactical planning is conducted and how the different plans are connected. The study complements earlier retail planning studies by showing the sequence of planning phases and by studying the fragmented plans as a process. The master category planning is important and sets borders for the other p...

30 CFR 282.24 - Mining Plan.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Mining Plan. 282.24 Section 282.24 Mineral... § 282.24 Mining Plan. All OCS mineral development and production activities shall be conducted in accordance with a Mining Plan submitted by the lessee and approved by the Director. A Mining Plan shall...

40 CFR 62.10850 - Identification of Plan.

Science.gov (United States)

2010-07-01

... from existing sulfuric acid production plants as adopted by the Texas Air Control Board (TACB) on May... (CONTINUED) APPROVAL AND PROMULGATION OF STATE PLANS FOR DESIGNATED FACILITIES AND POLLUTANTS Texas Plan for... Identification of Plan. (a) Identification of plan. Texas Plan for Control of Designated Pollutants from Existing...

Engaging migrants and other stakeholders to improve communication in cross-cultural consultation in primary care: a theoretically informed participatory study.

Science.gov (United States)

Lionis, Christos; Papadakaki, Maria; Saridaki, Aristoula; Dowrick, Christopher; O'Donnell, Catherine A; Mair, Frances S; van den Muijsenbergh, Maria; Burns, Nicola; de Brún, Tomas; O'Reilly de Brún, Mary; van Weel-Baumgarten, Evelyn; Spiegel, Wolfgang; MacFarlane, Anne

2016-07-22

Guidelines and training initiatives (G/TIs) are available to support communication in cross-cultural consultations but are rarely implemented in routine practice in primary care. As part of the European Union RESTORE project, our objective was to explore whether the available G/TIs make sense to migrants and other key stakeholders and whether they could collectively choose G/TIs and engage in their implementation in primary care settings. As part of a comparative analysis of 5 linked qualitative case studies, we used purposeful and snowball sampling to recruit migrants and other key stakeholders in primary care settings in Austria, England, Greece, Ireland and the Netherlands. A total of 78 stakeholders participated in the study (Austria 15, England 9, Ireland 11, Greece 16, Netherlands 27), covering a range of groups (migrants, general practitioners, nurses, administrative staff, interpreters, health service planners). We combined Normalisation Process Theory (NPT) and Participatory Learning and Action (PLA) research to conduct a series of PLA style focus groups. Using a standardised protocol, stakeholders' discussions about a set of G/TIs were recorded on PLA commentary charts and their selection process was recorded through a PLA direct-ranking technique. We performed inductive and deductive thematic analysis to investigate sensemaking and engagement with the G/TIs. The need for new ways of working was strongly endorsed by most stakeholders. Stakeholders considered that they were the right people to drive the work forward and were keen to enrol others to support the implementation work. This was evidenced by the democratic selection by stakeholders in each setting of one G/TI as a local implementation project. This theoretically informed participatory approach used across 5 countries with diverse healthcare systems could be used in other settings to establish positive conditions for the start of implementation journeys for G/TIs to improve healthcare for

Digital Radiography and Computed Tomography (DRCT) Product Improvement Plan (PIP)

Energy Technology Data Exchange (ETDEWEB)

Tim Roney; Bob Pink; Karen Wendt; Robert Seifert; Mike Smith

2010-12-01

The Idaho National Laboratory (INL) has been developing and deploying x-ray inspection systems for chemical weapons containers for the past 12 years under the direction of the Project Manager for Non-Stockpile Chemical Materiel (PMNSCM). In FY-10 funding was provided to advance the capabilities of these systems through the DRCT (Digital Radiography and Computed Tomography) Product Improvement Plan (PIP), funded by the PMNSCM. The DRCT PIP identified three research tasks; end user study, detector evaluation and DRCT/PINS integration. Work commenced in February, 2010. Due to the late start and the schedule for field inspection of munitions at various sites, it was not possible to spend sufficient field time with operators to develop a complete end user study. We were able to interact with several operators, principally Mr. Mike Rowan who provided substantial useful input through several discussions and development of a set of field notes from the Pueblo, CO field mission. We will be pursuing ongoing interactions with field personnel as opportunities arise in FY-11.

Writing a successful business plan.

Science.gov (United States)

Haag, A B

1997-01-01

1. In creating and building a business, the entrepreneur assumes all the responsibilities for its development and management, as well as the risks and risks and rewards. Many businesses do not survive because business owners fail to develop an effective plan. 2. The business plan focuses on major areas of concern and their contribution to the success of a new business. The finished product communicates the product/service to others and provides the basis for the financial proposal. 3. Planning helps identify customers, market area, pricing strategy, and competitive conditions. It aids in decision making and is an essential guide for operating a business successfully and measuring progress. 4. The business plan not only serves as a mechanism for obtaining any needed financial resources, but also indicates the future direction of the company.

BUSINESS PLANS INFORMED BY DESIGN

DEFF Research Database (Denmark)

Petersen, Sørren Ingomar; Heebøll, John

2011-01-01

Today the value created by applying design at a business model and innovation level as opposed to a design and process level is marginal. Interviews with product developers from academia and industry suggest this is due to a lack of design perspective when formulating and evaluating business plans...... types. These were the design of products based on sustainable and on disruptive technologies. In conclusion, we recommend a procedure to align and translate business plan content into inspirational design briefs for enhancing design concept synthesis performance........ To remedy this, we propose including Design Quality Criteria drivers in the formulation of business plans. While auditing entrepreneurial business plans and design briefs content gaps were revealed between them. Strategy and context differences as well as a negative correlation between investors’ business...

Partnerships between Aboriginal Organizations and Academics

Directory of Open Access Journals (Sweden)

Clément Chartier

2015-05-01

Full Text Available The article addresses the importance of the partnership between university professors and the Métis community. The Métis are a distinct nation and people that emerged in the northwest of what is now Canada and a bit into the United States through a process of ethnogenesis. The Métis Nation expressed its nationhood and defended its territory militarily in 1870 and again in 1885. Subsequently, Canada dealt with the Métis as individuals by implementing a scrip system, which displaced the Métis from their lands. In the 1980s and 1990s, the Métis Nation, along with other Aboriginal peoples, engaged in a constitutional process that witnessed limited success. Following that process, in 1993, the Métis moved their fight to the courts as many of their citizens were being charged with hunting and fishing infractions. This process necessitated the need for historical research and expert testimony, so the already emerging relationships with academia became more pronounced with progressive professors engaging in preparing expert reports and testifying at trial. Outside of the courts, research alliances were also engaged in. The outlook for the Métis Nation is more and more positive. The partnerships with academia has been a key contributor to this movement forward.

Sales and operations planning

DEFF Research Database (Denmark)

Kjellsdotter, Linea; Dukovska-Popovska, Iskra; Kaipia, Riikka

2013-01-01

This paper explores how the use of sales and operations planning (S&OP) may deal with the challenges set by the planning environment by investigating S&OP at four Scandinavian industrial food producers. Variables connected to the product and market, e.g. perishability, customer service elements...

Process quality planning of quality function deployment for carrot syrup

Science.gov (United States)

Ekawati, Yurida; Noya, Sunday; Widjaja, Filemon

2017-06-01

Carrot products are rarely available in the market. Based on previous research that had been done using QFD to generate product design of carrots products, the research to produce the process quality planning had been carried out. The carrot product studied was carrot syrup. The research resulted in a process planning matrix for carrot syrup. The matrix gives information about critical process plan and the priority of the critical process plan. The critical process plan on the production process of carrot syrup consists of carrots sorting, carrots peeling, carrots washing, blanching process, carrots cutting, the making of pureed carrots, filtering carrot juice, the addition of sugar in carrot juice, the addition of food additives in carrot juice, syrup boiling, syrup filtering, syrup filling into the bottle, the bottle closure and cooling. The information will help the design of the production process of carrot syrup.

Development and planning of plant for the high-pressure extraction of natural products

Energy Technology Data Exchange (ETDEWEB)

Eggers, R; Tschiersch, R [Thyssen Industrie A.G., Witten (Germany, F.R.)

1978-11-01

Important criteria in the designing of plant for the recovery of carrier or extract are reviewed, especially for the extraction of natural products with supercritical CO/sub 2/. The quantities to be determined in the planning of a large-scale plant are outlined and a typical process, the extraction of spices, is discussed in detail. The plant components and assemblies are presented together with their particular process engineering and construction characteristics. Finally, the thermodynamic aspects are dealt with in more detail and ways of optimizing a large-scale plant and reducing the power consumption are outlined. Particular attention is paid to the question of optimization regarding the most economic method of operation of such a plant in the future.

A methodology for model-based planning and evaluation of energy efficiency in production; Eine Methodik zur modellbasierten Planung und Bewertung der Energieeffizienz in der Produktion

Energy Technology Data Exchange (ETDEWEB)

Haag, Holger

2013-08-01

As global demand is rising constantly, the sustainable use of natural resources is a central challenge for the next years. This high demand leads to shortages and thus to rising costs of energy purchase. Manufacturing companies are facing global competition and improving their ressource efficiency can lead to both economic and ecologic benefits. But to increase the energy efficiency in production, interrelationships within the shop floor must be understood and suitable control variables have to be identified and applied. The methodology developed in this thesis addresses these aspects and merges them to a model-based approach for the planning, evaluation and optimization of the energy consumption in factories. The basic methodology focuses on a state based modeling approach. This allows linking the states to the specific energy profiles. Therefore not only the resources of the main processes but also the peripheral systems have to be considered. The integration of process planning makes it possible to examine and evaluate different constellations of parameters during the planning phase already. This is important as the main aspects of the energetic behavior of a production are determined in this phase. Thus, the work planner is given the opportunity to get feedback concerning the energy efficiency and the energetic behavior of the planned system. The additional consideration of energetic aspects in the production planning and control allows operating the whole production continuously at the energetically best operating point by initiating suitable measures. This method is implemented using a bidirectional messaging system which is capable to manage a permanent exchange of data between the management system and the resources in the shop floor. A developed key performance indicator (KPI) system forms the basis to evaluate the different parameter sets or possible scenarios. Including the classic objectives of production too, the user of the KPI system not only

15 CFR 930.73 - OCS plan.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false OCS plan. 930.73 Section 930.73...) Exploration, Development and Production Activities § 930.73 OCS plan. (a) The term “OCS plan” means any plan... described in detail in OCS plans approved by the Secretary of the Interior or designee prior to management...

Stimulating technological innovation : problem identification and intervention formulation with the technological innovation systems framework

NARCIS (Netherlands)

Kieft, A.C.

2017-01-01

The technological innovation systems (TIS) framework provides a theory to understand under what conditions technological innovations are successfully developed and implemented. The objective of this dissertation is to further strengthen this TIS intervention framework, which is the part of the TIS

10 CFR 436.43 - Procurement planning.

Science.gov (United States)

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Procurement planning. 436.43 Section 436.43 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Agency Procurement of Energy Efficient Products § 436.43 Procurement planning. (a) Agencies should consider the...

Aerocapacitor commercialization plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-12

The purpose of the Power-One Aerocapacitor Commercialization Plan is to communicate to members of management and to all employees the overall objectives of the corporation. Power-One, Inc., has participated in a US Federal Government Technology Reinvestment Project (TRP), entitled {open_quotes}Advanced Power Conversion based on the Aerocapacitor{close_quotes}: the project is a group effort, with Lawrence Livermore National Labs, GenCorp/Aerojet, PolyStor Corp. (a start-up company), and Power-One forming the consortium. The expected resulting technology is the {open_quotes}Aerocapacitor{close_quotes}, which possesses much higher performance levels than the usual capacitors on the market today. Power-One hopes to incorporate the Aerocapacitor into some of its products, hence enhancing their performance, as well as market privately-labeled aerocapacitors through its distribution channels. This document describes the details of Power-One`s plan to bring to market and commercialize the Aerocapacitor and Aerocapacitor-based products. This plan was formulated while Power-One was part of the Oerocap project. It has since pulled out of this project. What is presented in this plan is the work which was developed prior to the business decision to terminate this work.

Development Plans and Life Plans: Knowledge Sharing?

Directory of Open Access Journals (Sweden)

Juan José Vieco Albarracín

2010-02-01

Full Text Available This article explores the possibilities of establishing knowledge sharing between governmental development plans and the “life plans” (planes de vida made by indigenous organizations, in particular the life plan of the Asociación de Autoridades Indígenas del Resguardo Tikuna, Cocama, Yagua (Aticoya, municipality of Puerto Nariño, Amazonas, Colombia. Colombia’s Constitution of 1991 created the ETI (Entidad Territorial Indígena,“indigenous territorial entity” as a territorial unit, just like municipalities, departments, and districts. This means that indigenous reservations (or “reserves” or “preserves” and associations should manage public funds, for which they must design a life plan. This inclusion and recognition of indigenous peoples entails that those life plans should articulate with the municipal, departmental, and national development plans. The article illustrates this situation by comparing two welfare programs –Resa (Red de Seguridad Alimentaria “Food Security Network” and Familias Guardabosques (“Forest Ranger Families”– and two income-generating productive and service (tourism projects carried out by Aticoya and the local indigenous councils of communities on the Amazon and Loretoyacu Rivers.

Sales and operations planning

DEFF Research Database (Denmark)

Kjellsdotter, Linea; Dukovska-Popovska, Iskra; Kaipia, Riikka

2015-01-01

This paper investigates sales and operations planning (S&OP) at four Scandinavian industrial food producers in order to explore how the use of S&OP might help leaders to deal with the challenges set by the planning environment. Variables connected to the product and market, e.g., frequency of new...

Report to the parliament. Pluri-annual planning of power production investments; Rapport au parlement. Programmation pluriannuelle des investissements de production electrique

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-01-01

The article 6 of the law from February 10, 2000, relative to the modernization and development of the electric utility, schedules a pluri-annual planning of the production investments (PPI) which represents a concrete translation of the energy policy in the domain of electricity. The PPI will allow to reach the energy policy goals using a balanced development of the national production means in terms of primary energy sources, techniques of production and geographical distribution of investments. This document is the first PPI report to the parliament. It is based on the scheme of energy collective services and on a provisional status made by the manager of the transportation network (RTE). In 2010, renewable energies should cover 21% of the French electricity needs. This ratio will be reached mainly thanks to the development of wind power (7000 to 14000 MW of installed power, which represents 20 to 35 TWh of additional production). Hydro-power should be increased of 8 TWh max, depending on the public policies implemented, and biomass will have a significant contribution too. On the other hand, actions of mastery of the electricity demand will have to be implemented. From 2008 onward, the decommissioning of several power plants will impose to find new solutions to satisfy the peak power needs. The covering of consumption peaks requires a correlation study of the power peaks at the European scale. Finally, the situation of non-interconnected areas and of areas with fragile supply has been carefully considered. The creation of new power production means must be envisaged in most of these areas. (J.S.)

Radiation protection problems by the operation of the cyclotron facility

International Nuclear Information System (INIS)

Durcik, M.; Nikodemova, D.

1998-01-01

The Cyclotron Center in Bratislava will consist of two cyclotrons. First - cyclotron DC-72 with maximal energy of 72 MV for protons for making experiments, for teaching process, for radioisotope production as 123 I and for neutron and proton therapy. Second - compact cyclotron with maximal proton energy of 18 MeV will be used for radioisotopes production for medical diagnosis as 1 *F (fluorodeoxyglucose), 81 Rb/ 81 Kr generator. This paper deals with the radiation protection problems by the operation of tis cyclotron facility as radiation protection of workers, monitoring plan, ventilation, safety lock and limitation and radiation monitoring. For proposed and continuing practices at the accelerator facility, the following general principles have to be fulfilled: (1) practices should produce sufficient benefit to offset the radiation detriment they case (justification); (2) the magnitude of the individual doses should be kept as low as achievable (optimization of protection); (3) individual exposures are subject to dose limits and some control of risk from potential exposures (dose and risk limits)

Imaging, virtual planning, design, and production of patient-specific implants and clinical validation in craniomaxillofacial surgery.

Science.gov (United States)

Dérand, Per; Rännar, Lars-Erik; Hirsch, Jan-M

2012-09-01

The purpose of this article was to describe the workflow from imaging, via virtual design, to manufacturing of patient-specific titanium reconstruction plates, cutting guide and mesh, and its utility in connection with surgical treatment of acquired bone defects in the mandible using additive manufacturing by electron beam melting (EBM). Based on computed tomography scans, polygon skulls were created. Following that virtual treatment plans entailing free microvascular transfer of fibula flaps using patient-specific reconstruction plates, mesh, and cutting guides were designed. The design was based on the specification of a Compact UniLOCK 2.4 Large (Synthes(®), Switzerland). The obtained polygon plates were bent virtually round the reconstructed mandibles. Next, the resections of the mandibles were planned virtually. A cutting guide was outlined to facilitate resection, as well as plates and titanium mesh for insertion of bone or bone substitutes. Polygon plates and meshes were converted to stereolithography format and used in the software Magics for preparation of input files for the successive step, additive manufacturing. EBM was used to manufacture the customized implants in a biocompatible titanium grade, Ti6Al4V ELI. The implants and the cutting guide were cleaned and sterilized, then transferred to the operating theater, and applied during surgery. Commercially available software programs are sufficient in order to virtually plan for production of patient-specific implants. Furthermore, EBM-produced implants are fully usable under clinical conditions in reconstruction of acquired defects in the mandible. A good compliance between the treatment plan and the fit was demonstrated during operation. Within the constraints of this article, the authors describe a workflow for production of patient-specific implants, using EBM manufacturing. Titanium cutting guides, reconstruction plates for fixation of microvascular transfer of osteomyocutaneous bone grafts, and

Exercise-induced ST-T changes and severity of myocardial ischemia in single-vessel coronary artery disease

International Nuclear Information System (INIS)

Shimonagata, Tsuyoshi; Nishimura, Tsunehiko; Uehara, Toshiisa; Hayashida, Kohei; Takamiya, Makoto; Sumiyoshi, Tetsuya; Saito, Muneyasu.

1986-01-01

The purpose of this study was to evaluate how exercise-induced ST-T changes reflect the severity of myocardial ischemia in 66 patients with singlevessel disease (SVD) who underwent stress thallium scans. Quantitative assessment of myocardial ischemia was performed with thallium ischemic score (TIS) derived from circumferential profile analysis. Circumferential profiles of the initial and 4 hr redistribution myocardial image were generated for each of three views (ANT, LAO 45, LAO 70) and TIS was obtained as the average of the area between the initial and 4 hr redistribution profile for each view. In 66 patients with SVD, TIS were compared with coronary angiographic findings. TIS was correlated well with the severity of coronary artery stenosis. In addition, TIS was also correlated well with lung thallium uptake in 46 LAD disease. Therefore, these data proved that TIS was useful for the evaluation of the severity of myocardial ischemia. In 46 LAD disease, TIS, being as the indicator of the severity of myocardial ischemia, was compared precisely with results of stress electrocardiograms to evaluate how exercise-induced ST-T changes reflect the severity of myocardial ischemia. Patients with negative U wave had the highest mean TIS and those with horizontal or down sloping ST depression of 1.0 mm or more had higher mean TIS than those with slow upsloping ST depression of 1.5 mm or more, but there were no significant differences between these groups and those without ST-T change and the mean TIS was not different significantly between V 2-6 ST depression group and V 2-6 , II, III, a V F ST depression group. In conclusion, these results indicated that exercise-induced ST-T changes reflect the severity of myocardial ischemia in some degree but also has a limitation in evaluation of the severity of myocardial ischemia. (author)

Gravitační zákon - objev tisíciletí

Czech Academy of Sciences Publication Activity Database

Křížek, Michal

2009-01-01

Roč. 54, č. 2 (2009), s. 164-169 ISSN 0032-2423 R&D Projects: GA AV ČR(CZ) IAA100190803 Institutional research plan: CEZ:AV0Z10190503 Keywords : superdense mass * kepler's law * differential equations Subject RIV: BA - General Mathematics

Planning for Production of Freshwater Fish Fry in a Variable Climate in Northern Thailand.

Science.gov (United States)

Uppanunchai, Anuwat; Apirumanekul, Chusit; Lebel, Louis

2015-10-01

Provision of adequate numbers of quality fish fry is often a key constraint on aquaculture development. The management of climate-related risks in hatchery and nursery management operations has not received much attention, but is likely to be a key element of successful adaptation to climate change in the aquaculture sector. This study explored the sensitivities and vulnerability of freshwater fish fry production in 15 government hatcheries across Northern Thailand to climate variability and evaluated the robustness of the proposed adaptation measures. This study found that hatcheries have to consider several factors when planning production, including: taking into account farmer demand; production capacity of the hatchery; availability of water resources; local climate and other area factors; and, individual species requirements. Nile tilapia is the most commonly cultured species of freshwater fish. Most fry production is done in the wet season, as cold spells and drought conditions disrupt hatchery production and reduce fish farm demand in the dry season. In the wet season, some hatcheries are impacted by floods. Using a set of scenarios to capture major uncertainties and variability in climate, this study suggests a couple of strategies that should help make hatchery operations more climate change resilient, in particular: improving hatchery operations and management to deal better with risks under current climate variability; improving monitoring and information systems so that emerging climate-related risks are known sooner and understood better; and, research and development on alternative species, breeding programs, improving water management and other features of hatchery operations.

Effects of parallel planning on agreement production.

Science.gov (United States)

Veenstra, Alma; Meyer, Antje S; Acheson, Daniel J

2015-11-01

An important issue in current psycholinguistics is how the time course of utterance planning affects the generation of grammatical structures. The current study investigated the influence of parallel activation of the components of complex noun phrases on the generation of subject-verb agreement. Specifically, the lexical interference account (Gillespie & Pearlmutter, 2011b; Solomon & Pearlmutter, 2004) predicts more agreement errors (i.e., attraction) for subject phrases in which the head and local noun mismatch in number (e.g., the apple next to the pears) when nouns are planned in parallel than when they are planned in sequence. We used a speeded picture description task that yielded sentences such as the apple next to the pears is red. The objects mentioned in the noun phrase were either semantically related or unrelated. To induce agreement errors, pictures sometimes mismatched in number. In order to manipulate the likelihood of parallel processing of the objects and to test the hypothesized relationship between parallel processing and the rate of agreement errors, the pictures were either placed close together or far apart. Analyses of the participants' eye movements and speech onset latencies indicated slower processing of the first object and stronger interference from the related (compared to the unrelated) second object in the close than in the far condition. Analyses of the agreement errors yielded an attraction effect, with more errors in mismatching than in matching conditions. However, the magnitude of the attraction effect did not differ across the close and far conditions. Thus, spatial proximity encouraged parallel processing of the pictures, which led to interference of the associated conceptual and/or lexical representation, but, contrary to the prediction, it did not lead to more attraction errors. Copyright © 2015 Elsevier B.V. All rights reserved.

[How to carry out work on family planning after adopting production responsibility systems in rural areas].

Science.gov (United States)

Xiao, S H

1982-05-29

After the Third Meeting of the Eleventh People's Congress, the entire responsibility for agricultural production was transferred to a lower level. Peasants in various areas have adopted the so called production responsibility system, and the phenomenon of an increased population rate has also appeared in some areas. In this article, the author discusses how to solve these problems created by the new situation. The 1st step is try to control population growth through socialist propaganda education, administrative measures, economic incentives and punishments, and family planning work. The 2nd step is to popularize the practice of having only 1 child per household in the rural areas. The 2nd and 3rd child in each family should be controlled and prohibited. This policy formulated by the Central Government should be carried out thoroughly. Families which follow the policy and have only 1 child should be encouraged with economic rewards, and those families which have 2 or more children should be punished economically. The 3rd step is to establish a national work team to be in charge of family planning and birth control. There should be an ideological unity among the nation's leadership. Party members and cadres should establish themselves as good examples for the people so that the population control work may become successful.

Radioactive waste management plan. Plan 82

International Nuclear Information System (INIS)

1982-06-01

The report is the first account of the nuclear power utilities of Sweden concerning the plans for the final disposal of the radioactive waste products of the nuclear power. Part 2 describes the waste facilities in details. The layouts and estimated costs are presented. The decomissioning of nuclear power plants and the postponement of it is discussed. (G.B.)